Health Information Exchange as a Complex and Adaptive Construct: Scoping Review.

PubMed

Akhlaq, Ather; Sheikh, Aziz; Pagliari, Claudia

2017-01-25

To understand how the concept of Health Information Exchange (HIE) has evolved over time.  Supplementary analysis of data from a systematic scoping review of definitions of HIE from 1900 to 2014, involving temporal analysis of underpinning themes. The search identified 268 unique definitions of HIE dating from 1957 onwards; 103 in scientific databases and 165 in Google. These contained consistent themes, representing the core concept of exchanging health information electronically, as well as fluid themes, reflecting the evolving policy, business, organisational and technological context of HIE (including the emergence of HIE as an organisational 'entity'). These are summarised graphically to show how the concept has evolved around the world with the passage of time.  The term HIE emerged in 1957 with the establishment of Occupational HIE, evolving through the 1990s with concepts such as electronic data interchange and mobile computing technology; then from 2006-10 largely aligning with the US Government's health information technology strategy and the creation of HIEs as organisational entities, alongside the broader interoperability imperative, and continuing to evolve today as part of a broader international agenda for sustainable, information-driven health systems. The concept of HIE is an evolving and adaptive one, reflecting the ongoing quest for integrated and interoperable information to improve the efficiency and effectiveness of health systems, in a changing technological and policy environment.

Usability Definitions in a Dynamically Changing Information Environment

ERIC Educational Resources Information Center

Chen, Yu-Hui; Rorissa, Abebe; Germain, Carol Anne

2015-01-01

The authors compared Web usability definitions, collected from library professionals at academic institutions of the Association of Research Libraries (ARL) through online surveys in 2007 and 2012, to determine whether library practitioners' perspectives had altered as information technologies evolved during this time. The authors applied three…

Epistemological Dialogue of Validity: Building Validity in Educational and Social Research

ERIC Educational Resources Information Center

Cakir, Mustafa

2012-01-01

The notion of validity in the social sciences is evolving and is influenced by philosophy of science, critiques of objectivity, and epistemological debates. Methodology for validation of the knowledge claims is diverse across different philosophies of science. In other words, definition and the way to establish of validity have evolved as…

A Lakatosian Encounter with Probability

ERIC Educational Resources Information Center

Chick, Helen

2010-01-01

There is much to be learned and pondered by reading "Proofs and Refutations" by Imre Lakatos (Lakatos, 1976). It highlights the importance of mathematical definitions, and how definitions evolve to capture the essence of the object they are defining. It also provides an exhilarating encounter with the ups and downs of the mathematical reasoning…

A Lakatosian Encounter

ERIC Educational Resources Information Center

Chick, Helen

2010-01-01

There is much to be learned and pondered by reading "Proofs and Refutations," by Imre Lakatos. It highlights the importance of mathematical definitions, and how definitions evolve to capture the essence of the object they are defining. It also provides an exhilarating encounter with the ups and downs of the mathematical reasoning process, where…

The Evolving Role of Radiation Therapy in the Management of Malignant Melanoma

DOE Office of Scientific and Technical Information (OSTI.GOV)

Khan, Niloufer; Khan, Mohammad K., E-mail: drkhurram2000@gmail.com; Almasan, Alex

2011-07-01

The incidence of melanoma is rising in the United States, leading to an estimated 68,720 new diagnoses and 8,650 deaths annually. The natural history involves metastases to lymph nodes, lung, liver, brain, and often to other sites. Primary treatment for melanoma is surgical excision of the primary tumor and affected lymph nodes. The role of adjuvant or definitive radiation therapy in the treatment of melanoma remains controversial, because melanoma has traditionally been viewed as a prototypical radioresistant cancer. However, recent studies suggest that under certain clinical circumstances, there may be a significant role for radiation therapy in melanoma treatment. Stereotacticmore » radiosurgery for brain metastases has shown effective local control. High dose per fraction radiation therapy has been associated with a lower rate of locoregional recurrence of sinonasal melanoma. Plaque brachytherapy has evolved into a promising alternative to enucleation at the expense of moderate reduction in visual acuity. Adjuvant radiation therapy following lymphadenectomy in node-positive melanoma prevents local and regional recurrence. The newer clinical data along with emerging radiobiological data indicate that radiotherapy is likely to play a greater role in melanoma management and should be considered as a treatment option.« less

[Prevention and management of the conflict patient-doctor].

PubMed

Sassoon, D

2007-04-01

A surgeon's daily practice evolves according to techniques, but also according to a legal and associative environment. The patient is becoming a health consumer, demanding and informed, legitimately exacting security and transparency, but also compensation in the event of accidental injury. The constraints that weigh upon this profession are growing heavier: knowledge and respect of laws, ordinances and regulations are becoming essential and law suits more and more frequent. Ever present in surgery, risk evaluation and assessing the risk-benefit ratio for the patient must be clearly stated by the practitioner and his team, despite the inherent difficulties in sharing information. A classification of surgical risk facilitates an approach to the definitions of a fault, medical accident, iatrogenic condition or undesirable event. This is a fundamental concept, since precise criteria apply to a fault in the legal sense, whereas no normative definition exists for a medical fault. Prevention of conflict requires the implementation of collective steps aimed at ensuring security in a complex system, confidence between the surgeon and his patient based on appropriate information and strict adherence to current regulations. In the event of complications, difficult after-effects, objectively unsatisfactory results or those perceived as such by the patient, post-operative follow-up must face these difficulties squarely with transparency and responsibility. Following a legal summons involving the responsibility of the practitioner, management of the conflict between the physician and the patient requires solid preparation of the medical file and his active participation in the judicial expertise so as to best inform the judge.

Strategic Planning in Higher Education: Varying Definitions, Key Characteristics, Benefits, Pitfalls, and Good Approaches.

ERIC Educational Resources Information Center

Tan, David L.

Planning in higher education has evolved as a response to changes in the environment, such as expanding enrollments, student unrest, economic recession, and pressures for financial accountability. Strategic planning has emerged as one way institutions can handle and overcome the adversities of the future. Definitions of strategic planning are…

Standardizing the Term "Strategy" in Retail and Business Curriculum

ERIC Educational Resources Information Center

Song, So Young

2017-01-01

Strategy is a key concept in retail and business education. Yet, this important term has evolved to include many definitions, which can create confusion in the classroom environment. This paper proposes a standardized use of the term "strategy" in retail and business classrooms. It suggests a focused definition of strategy as "the…

Evolving Definitions of Autism and Impact on Eligibility for Developmental Disability Services: California Case Example

ERIC Educational Resources Information Center

Williams, Marian E.; Wheeler, Barbara Y.; Linder, Lisa; Jacobs, Robert A.

2017-01-01

When establishing eligibility for developmental disability (DD) services, definitions of specific diagnostic conditions, such as autism, impact policy. Under the Medicaid home and community-based waiver program, states have discretion in determining specific program or service eligibility criteria, the nature of supports to be provided, and the…

Interpersonal Relatedness and Self-Definition in Normal and Disrupted Personality Development: Retrospect and Prospect

ERIC Educational Resources Information Center

Luyten, Patrick; Blatt, Sidney J.

2013-01-01

Two-polarities models of personality propose that personality development evolves through a dialectic synergistic interaction between two fundamental developmental psychological processes across the life span--the development of interpersonal relatedness on the one hand and of self-definition on the other. This article offers a broad review of…

Damage control: Concept and implementation.

PubMed

Malgras, B; Prunet, B; Lesaffre, X; Boddaert, G; Travers, S; Cungi, P-J; Hornez, E; Barbier, O; Lefort, H; Beaume, S; Bignand, M; Cotte, J; Esnault, P; Daban, J-L; Bordes, J; Meaudre, E; Tourtier, J-P; Gaujoux, S; Bonnet, S

2017-12-01

The concept of damage control (DC) is based on a sequential therapeutic strategy that favors physiological restoration over anatomical repair in patients presenting acutely with hemorrhagic trauma. Initially described as damage control surgery (DCS) for war-wounded patients with abdominal penetrating hemorrhagic trauma, this concept is articulated in three steps: surgical control of lesions (hemostasis, sealing of intestinal spillage), physiological restoration, then surgery for definitive repair. This concept was quickly adapted for intensive care management under the name damage control resuscitation (DCR), which refers to the modalities of hospital resuscitation carried out in patients suffering from traumatic hemorrhagic shock within the context of DCS. It is based mainly on specific hemodynamic resuscitation targets associated with early and aggressive hemostasis aimed at prevention or correction of the lethal triad of hypothermia, acidosis and coagulation disorders. Concomitant integration of resuscitation and surgery from the moment of admission has led to the concept of an integrated DCR-DCS approach, which enables initiation of hemostatic resuscitation upon arrival of the injured person, improving the patient's physiological status during surgery without delaying surgery. This concept of DC is constantly evolving; it stresses management of the injured person as early as possible, in order to initiate hemorrhage control and hemostatic resuscitation as soon as possible, evolving into a concept of remote DCR (RDCR), and also extended to diagnostic and therapeutic radiological management under the name of radiological DC (DCRad). DCS is applied only to the most seriously traumatized patients, or in situations of massive influx of injured persons, as its universal application could lead to a significant and unnecessary excess-morbidity to injured patients who could and should undergo definitive treatment from the outset. DCS, when correctly applied, significantly improves the survival rate of war-wounded. Copyright © 2017 Elsevier Masson SAS. All rights reserved.

40 CFR 35.343 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-07-01

... ASSISTANCE Environmental Program Grants Pollution Prevention State Grants (section 6605) § 35.343 Definitions... Prevention State Grants program and to §§ 35.340 through 35.349: (a) Pollution prevention/source reduction is... other resources; or (ii) Protection of natural resources by conservation. (b) Pollution prevention...

Definition of Successful Aging by Elderly Canadian Males: The Manitoba Follow-Up Study

ERIC Educational Resources Information Center

Tate, Robert B.; Lah, Leedine; Cuddy, T. Edward

2003-01-01

Purpose: Although the concept of successful aging is used widely in the field of gerontology, there is no agreed-on standard or common underlying definition for measuring success in aging. Our recent survey of an elderly male population asked respondents to define "successful aging." This paper describes the themes that evolved from…

Protoptype integrated design (Pride) system reference manual. Volume 2: Schema definition

NASA Technical Reports Server (NTRS)

Fishwick, P. A.; Sutter, T. R.; Blackburn, C. L.

1983-01-01

An initial description of an evolving relational database schema is presented for the management of finite element model design and analysis data. The report presents a description of each relation including attribute names, data types, and definitions. The format of this report is such that future modifications and enhancements may be easily incorporated.

Definitions and Uses: Case Study of Teachers Implementing Project-Based Learning

ERIC Educational Resources Information Center

Tamim, Suha R.; Grant, Michael M.

2013-01-01

The purpose of this descriptive study was to explore inservice teachers' definitions of project-based learning (PjBL) and their accounts on the meaning of their PjBL implementations. A purposive sample of six teachers from grades four through twelve in public and private schools participated. Three themes evolved from inductive analysis: (1)…

On physical scales of dark matter halos

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zemp, Marcel, E-mail: mzemp@pku.edu.cn

2014-09-10

It is common practice to describe formal size and mass scales of dark matter halos as spherical overdensities with respect to an evolving density threshold. Here, we critically investigate the evolutionary effects of several such commonly used definitions and compare them to the halo evolution within fixed physical scales as well as to the evolution of other intrinsic physical properties of dark matter halos. It is shown that, in general, the traditional way of characterizing sizes and masses of halos dramatically overpredicts the degree of evolution in the last 10 Gyr, especially for low-mass halos. This pseudo-evolution leads to themore » illusion of growth even though there are no major changes within fixed physical scales. Such formal size definitions also serve as proxies for the virialized region of a halo in the literature. In general, those spherical overdensity scales do not coincide with the virialized region. A physically more precise nomenclature would be to simply characterize them by their very definition instead of calling such formal size and mass definitions 'virial'. In general, we find a discrepancy between the evolution of the underlying physical structure of dark matter halos seen in cosmological structure formation simulations and pseudo-evolving formal virial quantities. We question the importance of the role of formal virial quantities currently ubiquitously used in descriptions, models, and relations that involve properties of dark matter structures. Concepts and relations based on pseudo-evolving formal virial quantities do not properly reflect the actual evolution of dark matter halos and lead to an inaccurate picture of the physical evolution of our universe.« less

40 CFR 35.662 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-07-01

... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS AND OTHER FEDERAL ASSISTANCE STATE AND LOCAL ASSISTANCE Environmental Program Grants for Tribes Pollution Prevention Grants (section 6605) § 35.662 Definitions. The following definition applies to the Pollution Prevention Grant program and to §§ 35.660...

40 CFR 35.662 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-07-01

... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS AND OTHER FEDERAL ASSISTANCE STATE AND LOCAL ASSISTANCE Environmental Program Grants for Tribes Pollution Prevention Grants (section 6605) § 35.662 Definitions. The following definition applies to the Pollution Prevention Grant program and to §§ 35.660...

How should an incident case of atopic dermatitis be defined? A systematic review of primary prevention studies

PubMed Central

Simpson, Eric L.; Keck, Laura E.; Chalmers, Joanne R.; Williams, Hywel C.

2012-01-01

Background Eczema prevention is now an active area of dermatologic and allergic research. Defining an incident case is therefore a prerequisite for such as study. Objective We sought to examine how an incident case of atopic dermatitis was defined in previous atopic dermatitis prevention studies in order to make recommendations on a standard definition of new atopic dermatitis cases for use in future prevention trials. Methods We conducted a systematic review of controlled interventional atopic dermatitis prevention studies using searches of Medline and Cochrane databases from 1980 to the end of January 2011. Studies that included atopic dermatitis as a secondary outcome, such as asthma prevention trials, were included. Results One hundred and two (102) studies were included in the final analysis, of which 27 (26.5%) did not describe any criteria for defining an incident case of atopic dermatitis. Of the remaining 75 studies with reported disease criteria, the Hanifin-Rajka criteria were the most commonly used (28 studies). A disease definition unique to that particular study (21 studies) was the second most commonly used disease definition, although the sources for such novel definitions were not cited. Conclusions The results from this systematic review highlight the need for improved reporting and standardization of the definition used for an incident case in atopic dermatitis prevention studies. Most prevention studies have used disease definitions such as the Hanifin-Rajka criteria that include disease chronicity. While acceptable for cumulative incidence outcomes, inclusion of disease chronicity precludes the precise measurement of disease onset. We propose a definition based on existing scientific studies that could be used in future prospective studies. PMID:22424882

Evolving early (pre-dementia) Alzheimer's disease trials: suit the outcomes to the population and study design.

PubMed

Doody, R S

2010-04-01

Assuming that some cases of Alzheimer's disease (AD) could be prevented or delayed, prevention trials will be developed for this neurodegenerative condition. Initially, stakeholders will have to agree about the definition of prevention-true primary prevention, meaning the prevention of AD neuropathological changes; the prevention of clinical signs and symptoms that often augur AD; or preventing the progression of signs and symptoms to full-blown dementia. True primary prevention trials will have to rely completely upon neuroimaging or biomarker outcomes that reflect AD pathology. On the other hand, trials designed to prevent signs and symptoms of dementia will require researchers to agree on the phenomenology that would constitute an unequivocal endpoint: cognitive worsening on one or more measure compared to a normative group; development of Mild cognitive impairment (MCI); or development of Alzheimer's dementia. Prevention trials utilizing any of these outcomes in the general public will be large, will have to utilize low risk public health interventions, and might therefore have only a small impact (treatment effect size), especially if the studies are too short or the study populations are too diverse. An alternative to interventions aimed at the general public would be any attempt to prevent signs and symptoms of dementia in individuals thought to be at an increased risk for clinical dementia. These trials could try to reduce the development of signs and symptoms of dementia in cognitively normal subjects, or they could try to prevent progression from some form of Mild Cognitive Impairment to AD, or they could have the more subtle goal of reducing the accumulation of subclinical deficits in MCI subjects. If the populations for these trials are limited to individuals who have abnormal laboratory and neuroimaging studies associated with AD neuropathology, the results will not generalize to biomarker-negative, at risk individuals, who are likely to constitute the majority of any clinically relevant study population. Outcome measures for each study design will depend upon the characteristics of the study.

Splicing the Divide: A Review of Research on the Evolving Digital Divide among K-12 Students

ERIC Educational Resources Information Center

Dolan, Jennifer E.

2016-01-01

The digital divide has narrowed with regard to one definition of access to technology--the binary view of the "haves" and "have-nots." However, use of technology at home and in school is not equitable for all students. According to recent literature, a broader and more nuanced definition of the technological divide is necessary…

Acute resuscitation of the unstable adult trauma patient: bedside diagnosis and therapy

PubMed Central

Kirkpatrick, Andrew W.; Ball‡, Chad G.; D'Amours, Scott K.; Zygun, David

2008-01-01

Traumatic injury remains the leading cause of potentially preventable death in Canadians under age 40 years. Although only a minority of patients present with hemodynamic instability, these patients have a significant chance of dying. The causes of instability must be recognized and corrected quickly by using a systematic approach. To allow key supportive interventions to be undertaken swiftly, it is more important to identify and prioritize systemic compromise than to confirm specific diagnoses. Most potentially preventable trauma death relates to airway obstruction, hemopneumothorax, intracranial hemorrhage and intracavitary bleeding. Definitive airway control should be assured as a first priority. Hemopneumothoraces are typically addressed by chest tube insertion, although thoracic exploration will occasionally be urgently required. Hemorrhage control is much more important than fluid resuscitation and mandates the earliest possible definitive management. Unstable patients nearing physiological exhaustion require abbreviated or “damage-control” surgical tactics. This should be recognized early in the resuscitation rather than late in an operative procedure. The management of expanding intracranial hemorrhage requires optimization of oxygenation, ventilation and circulatory support while urgent CT and expert neurosurgical care are provided. Polytrauma presenting with head injury challenges the most developed of trauma systems, necessitating thoughtful prioritization of care and taking into consideration local capabilities. Bedside trauma sonography is an evolving tool that complements the physical examination during an initial survey. Future breakthroughs in trauma resuscitation may involve procoagulant medications, imaging technology, circulatory assist techniques and the use of inflammatory modulators. The greatest future challenge in trauma care, though, will be the provision of basic organized resuscitative care to the global community. PMID:18248707

Deep remission: a new concept?

PubMed

Colombel, Jean-Frédéric; Louis, Edouard; Peyrin-Biroulet, Laurent; Sandborn, William J; Panaccione, Remo

2012-01-01

Crohn's disease (CD) is a chronic inflammatory disorder characterized by periods of clinical remission alternating with periods of relapse defined by recurrent clinical symptoms. Persistent inflammation is believed to lead to progressive bowel damage over time, which manifests with the development of strictures, fistulae and abscesses. These disease complications frequently lead to a need for surgical resection, which in turn leads to disability. So CD can be characterized as a chronic, progressive, destructive and disabling disease. In rheumatoid arthritis, treatment paradigms have evolved beyond partial symptom control alone toward the induction and maintenance of sustained biological remission, also known as a 'treat to target' strategy, with the goal of improving long-term disease outcomes. In CD, there is currently no accepted, well-defined, comprehensive treatment goal that entails the treatment of both clinical symptoms and biologic inflammation. It is important that such a treatment concept begins to evolve for CD. A treatment strategy that delays or halts the progression of CD to increasing damage and disability is a priority. As a starting point, a working definition of sustained deep remission (that includes long-term biological remission and symptom control) with defined patient outcomes (including no disease progression) has been proposed. The concept of sustained deep remission represents a goal for CD management that may still evolve. It is not clear if the concept also applies to ulcerative colitis. Clinical trials are needed to evaluate whether treatment algorithms that tailor therapy to achieve deep remission in patients with CD can prevent disease progression and disability. Copyright © 2012 S. Karger AG, Basel.

The evolving definition of a chondrodysplasia?

PubMed

Horton, William A

2003-01-01

Most individuals who deal with chondrodysplasias would agree that this term refers collectively to a genetically and clinically heterogeneous group of disorders of skeletal development and growth. But they might not agree on what constitutes a specific chondrodysplasia. Indeed, the way in which a specific chondrodysplasia is defined has evolved substantially over the past several decades. David Rimoin, to whom this special issue is dedicated, has played a vital role in this evolution.

22 CFR 303.2 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-04-01

... or graduate higher education, or an institution of professional or vocational education which... examples are not intended to be all-inclusive. Moreover, as traditional methods of news delivery evolve (e...

22 CFR 303.2 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-04-01

... or graduate higher education, or an institution of professional or vocational education which... examples are not intended to be all-inclusive. Moreover, as traditional methods of news delivery evolve (e...

Neisseria meningitidis: pathogenesis and immunity.

PubMed

Pizza, Mariagrazia; Rappuoli, Rino

2015-02-01

The recent advances in cellular microbiology, genomics, and immunology has opened new horizons in the understanding of meningococcal pathogenesis and in the definition of new prophylactic intervention. It is now clear that Neissera meningitidis has evolved a number of surface structures to mediate interaction with host cells and a number of mechanisms to subvert the immune system and escape complement-mediated killing. In this review we report the more recent findings on meningococcal adhesion and on the bacteria-complement interaction highlighting the redundancy of these mechanisms. An effective vaccine against meningococcus B, based on multiple antigens with different function, has been recently licensed. The antibodies induced by the 4CMenB vaccine could mediate bacterial killing by activating directly the classical complement pathway or, indirectly, by preventing binding of fH on the bacterial surface and interfering with colonization. Copyright © 2014 The Author. Published by Elsevier Ltd.. All rights reserved.

Evolving Patient Compliance Trends: Integrating Clinical, Insurance, and Extrapolated Socioeconomic Data

PubMed Central

Klobusicky, Joseph J.; Aryasomayajula, Arun; Marko, Nicholas

2015-01-01

Efforts toward improving patient compliance in medication focus on either identifying trends in patient features or studying changes through an intervention. Our study seeks to provide an important link between these two approaches through defining trends of evolving compliance. In addition to using clinical covariates provided through insurance claims and health records, we also extracted census based data to provide socioeconomic covariates such as income and population density. Through creating quadrants based on periods of medicine intake, we derive several novel definitions of compliance. These definitions revealed additional compliance trends through considering refill histories later in a patient’s length of therapy. These results suggested that the link between patient features and compliance includes a temporal component, and should be considered in policymaking when identifying compliant subgroups. PMID:26958212

An evolving effective stress approach to anisotropic distortional hardening

DOE PAGES

Lester, B. T.; Scherzinger, W. M.

2018-03-11

A new yield surface with an evolving effective stress definition is proposed for consistently and efficiently describing anisotropic distortional hardening. Specifically, a new internal state variable is introduced to capture the thermodynamic evolution between different effective stress definitions. The corresponding yield surface and evolution equations of the internal variables are derived from thermodynamic considerations enabling satisfaction of the second law. A closest point projection return mapping algorithm for the proposed model is formulated and implemented for use in finite element analyses. Finally, select constitutive and larger scale boundary value problems are solved to explore the capabilities of the model andmore » examine the impact of distortional hardening on constitutive and structural responses. Importantly, these simulations demonstrate the tractability of the proposed formulation in investigating large-scale problems of interest.« less

An evolving effective stress approach to anisotropic distortional hardening

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lester, B. T.; Scherzinger, W. M.

A new yield surface with an evolving effective stress definition is proposed for consistently and efficiently describing anisotropic distortional hardening. Specifically, a new internal state variable is introduced to capture the thermodynamic evolution between different effective stress definitions. The corresponding yield surface and evolution equations of the internal variables are derived from thermodynamic considerations enabling satisfaction of the second law. A closest point projection return mapping algorithm for the proposed model is formulated and implemented for use in finite element analyses. Finally, select constitutive and larger scale boundary value problems are solved to explore the capabilities of the model andmore » examine the impact of distortional hardening on constitutive and structural responses. Importantly, these simulations demonstrate the tractability of the proposed formulation in investigating large-scale problems of interest.« less

Quality improvement in pediatric sepsis.

PubMed

Melendez, Elliot; Bachur, Richard

2015-06-01

Although there is abundant literature detailing the impact of quality improvement in adult sepsis, the pediatric literature is lacking. Despite consensus definitions for sepsis, which patients along the sepsis spectrum should receive aggressive management and the exact onset of sepsis ('time zero') are not clearly established. In the adult emergency department (ED), sepsis onset is defined as the time of entry into the ED; however, this definition cannot be applied to hospitalized patients or patients who evolve during their ED course. Since the time of sepsis onset will dictate the timeliness of subsequent process measures, the variable definitions in the literature make it difficult to generalize findings among prior studies. Despite the variation in defining time zero, aggressive fluid administration, timely antibiotics, and compliance with sepsis bundles have been shown to improve mortality and to reduce hospital and intensive care length of stay. In addition, early identification tools show promise in beginning to define sepsis onset and retrospective search tools may allow improved case finding of those children of concern for sepsis. Quality improvement in pediatric sepsis is evolving. As we continue to define quality measures, we must standardize the definition of sepsis onset. This definition should be applicable to any treatment venue to ensure measures can be evaluated across all settings. In addition, we must delineate which patients along the sepsis spectrum should be candidates for timely interventions and standardize other outcome measures beyond mortality.

The culture of complexion: the impacts of society's role in shaping the definition of beauty.

PubMed

Carlock, Sarah; Russell, Brian

2015-05-01

The definition of beauty has evolved as the trends valued by the top of society change. For centuries, fair skin was a requirement of the Western definition of beauty; however, a shift in the 1920s made tanned skin the new standard. In this article, smoking and tanning are presented as risky behaviors that are perpetuated through industry advertising and exploitation of the authority of health professionals. The article further explores the culture of complexion in Western society before and after the 1920s as well as the consequences of tanning and efforts to rewrite society's definition of beauty.

Minimizing preventable trauma deaths in a limited-resource setting: a test-case of a multidisciplinary panel review approach at the Komfo Anokye Teaching Hospital in Ghana.

PubMed

Yeboah, Dominic; Mock, Charles; Karikari, Patrick; Agyei-Baffour, Peter; Donkor, Peter; Ebel, Beth

2014-07-01

Our objectives were to determine the proportion of preventable trauma deaths at a large trauma hospital in Kumasi, Ghana, and to identify opportunities for the improvement of trauma care. A multidisciplinary panel of experts evaluated pre-hospital, hospital, and postmortem data of consecutive trauma patients who died over a 5-month period in 2006-2007 at the Komfo Anokye Teaching Hospital. The panel judged the preventability of each death. For preventable and potentially preventable deaths, deficiencies in care that contributed to their deaths were identified. The panel reviewed 231 trauma deaths. Of these, 84 charts had sufficient information to review preventable factors. The panel determined that 23 % of trauma deaths were definitely preventable, 37 % were potentially preventable, and 40 % were not preventable. One main deficiency in care was identified for each of the 50 definitely preventable and potentially preventable deaths. The most common deficiencies were pre-hospital delays (44 % of the 50 deficiencies), delay in treatment (32 %), and inadequate fluid resuscitation (22 %). Among the 19 definitely preventable deaths, the most common cause of death was hemorrhage (47 %), and the most common deficiencies were inadequate fluid resuscitation (37 % of deficiencies in this group) and pre-hospital delay (37 %). A high proportion of trauma fatalities might have been preventable by decreasing pre-hospital delays, adequate resuscitation in hospital, and earlier initiation of care, including definitive surgical management. The study also showed that preventable death panel reviews are a feasible and useful quality improvement method in the study setting.

Hypernetwork generation for multi-modal transportation system modeling.

DOT National Transportation Integrated Search

2013-04-01

The transportation debate has evolved in recent decades to include ideas such as sustainability and livability alongside mobility and safety. Definitional complexities aside, there is no doubt that this evolution has created a national transportation...

Medicine as a profession.

PubMed

Funder, John W

2010-06-01

Over half a century ago, a Canadian judge defined a profession in a way that resonates still today, not only for lawyers and doctors, but for the current wide variety of professions and professionals. This article is a reflection on this definition. It briefly considers the historical context within which the knowledge base that characterises a profession evolved and what the various component parts of the judge's definition entail. A final consideration goes beyond the terms of the definition proposed--that of our ethical responsibility as professionals to stand up and be counted and, in the context of the disorder around us, to speak out.

42 CFR 51b.202 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-10-01

... HEALTH SERVICES Grants for Childhood Immunization Programs § 51b.202 Definitions. As used in this subpart: Childhood immunization program means a preventive health service program to immunize children against vaccine preventable diseases including poliomyelitis, measles, mumps, rubella, diphtheria, pertussis, and...

42 CFR 51b.202 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-10-01

... HEALTH SERVICES Grants for Childhood Immunization Programs § 51b.202 Definitions. As used in this subpart: Childhood immunization program means a preventive health service program to immunize children against vaccine preventable diseases including poliomyelitis, measles, mumps, rubella, diphtheria, pertussis, and...

42 CFR 51b.202 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-10-01

... HEALTH SERVICES Grants for Childhood Immunization Programs § 51b.202 Definitions. As used in this subpart: Childhood immunization program means a preventive health service program to immunize children against vaccine preventable diseases including poliomyelitis, measles, mumps, rubella, diphtheria, pertussis, and...

42 CFR 51b.202 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-10-01

... HEALTH SERVICES Grants for Childhood Immunization Programs § 51b.202 Definitions. As used in this subpart: Childhood immunization program means a preventive health service program to immunize children against vaccine preventable diseases including poliomyelitis, measles, mumps, rubella, diphtheria, pertussis, and...

42 CFR 51b.202 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-10-01

... HEALTH SERVICES Grants for Childhood Immunization Programs § 51b.202 Definitions. As used in this subpart: Childhood immunization program means a preventive health service program to immunize children against vaccine preventable diseases including poliomyelitis, measles, mumps, rubella, diphtheria, pertussis, and...

Classification of movement disorders.

PubMed

Fahn, Stanley

2011-05-01

The classification of movement disorders has evolved. Even the terminology has shifted, from an anatomical one of extrapyramidal disorders to a phenomenological one of movement disorders. The history of how this shift came about is described. The history of both the definitions and the classifications of the various neurologic conditions is then reviewed. First is a review of movement disorders as a group; then, the evolving classifications for 3 of them--parkinsonism, dystonia, and tremor--are covered in detail. Copyright © 2011 Movement Disorder Society.

Redefining disease emergence to improve prioritization and macro-ecological analyses.

PubMed

Rosenthal, Samantha R; Ostfeld, Richard S; McGarvey, Stephen T; Lurie, Mark N; Smith, Katherine F

2015-12-01

Microbial infections are as old as the hosts they sicken, but interest in the emergence of pathogens and the diseases they cause has been accelerating rapidly. The term 'emerging infectious disease' was coined in the mid-1900s to describe changes in disease dynamics in the modern era. Both the term and the phenomena it is meant to characterize have evolved and diversified over time, leading to inconsistencies and confusion. Here, we review the evolution of the term 'emerging infectious disease' (EID) in the literature as applied to human hosts. We examine the pathways (e.g., speciation or strain differentiation in the causative agent vs. rapid geographic expansion of an existing pathogen) by which diseases emerge. We propose a new framework for disease and pathogen emergence to improve prioritization. And we illustrate how the operational definition of an EID affects conclusions concerning the pathways by which diseases emerge and the ecological and socioeconomic drivers that elicit emergence. As EIDs appear to be increasing globally, and resources for science level off or decline, the research community is pushed to prioritize its focus on the most threatening diseases, riskiest potential pathogens, and the places they occur. The working definition of emerging infectious diseases and pathogens plays a crucial role in prioritization, but we argue that the current definitions may be impeding these efforts. We propose a new framework for classifying pathogens and diseases as "emerging" that distinguishes EIDs from emerging pathogens and novel potential pathogens. We suggest prioritization of: 1) EIDs for adaptation and mitigation, 2) emerging pathogens for preventive measures, and 3) novel potential pathogens for intensive surveillance.

Human factors in aviation maintenance, phase two : progress report.

DOT National Transportation Integrated Search

1993-04-01

In this second phase of research on Human Factors in Aviation Maintenance, the emphasis has evolved from problem definition to development of demonstrations and prototypes. These demonstrations include a computer-based training simulation for trouble...

Creativity and Giftedness--A Comparative Perspective.

ERIC Educational Resources Information Center

Paulsen, Willem J.

This paper reviews literature-based giftedness definitions which have evolved as different manifestations of giftedness have been recognized. Various fields of giftedness are outlined, including mental, creative, specific academic, psychosocial (leadership), performing arts, kinesthetic (athletic), manipulative skills, and…

Data Safe Havens and Trust: Toward a Common Understanding of Trusted Research Platforms for Governing Secure and Ethical Health Research

PubMed Central

Nicholls, Jacqueline; Dobbs, Christine; Sethi, Nayha; Cunningham, James; Ainsworth, John; Heaven, Martin; Peacock, Trevor; Peacock, Anthony; Jones, Kerina; Laurie, Graeme; Kalra, Dipak

2016-01-01

In parallel with the advances in big data-driven clinical research, the data safe haven concept has evolved over the last decade. It has led to the development of a framework to support the secure handling of health care information used for clinical research that balances compliance with legal and regulatory controls and ethical requirements while engaging with the public as a partner in its governance. We describe the evolution of 4 separately developed clinical research platforms into services throughout the United Kingdom-wide Farr Institute and their common deployment features in practice. The Farr Institute is a case study from which we propose a common definition of data safe havens as trusted platforms for clinical academic research. We use this common definition to discuss the challenges and dilemmas faced by the clinical academic research community, to help promote a consistent understanding of them and how they might best be handled in practice. We conclude by questioning whether the common definition represents a safe and trustworthy model for conducting clinical research that can stand the test of time and ongoing technical advances while paying heed to evolving public and professional concerns. PMID:27329087

Targeting Alpha5 Beta1 Integrin to Prevent Metastatic Breast Cancer Cell Invasion: PhScN Target Site Definition and Plasma Stability

DTIC Science & Technology

2015-11-01

increased PhScN potency as a result of preventing endoproteolytic degradation. Finally, the in vivo lung extravasation and colonization data, as well as...successful colonization are late stages in breast cancer progression that are ultimately fatal. Hence, prevention of extravasation which leads to colony...Award Number: TITLE: “Targeting Alpha5 Beta1 Integrin to Prevent Metastatic Breast Cancer Cell Invasion: PhScN Target Site Definition and Plasma

The Viking biological investigation - Preliminary results

NASA Technical Reports Server (NTRS)

Klein, H. P.; Oyama, V. I.; Berdahl, B. J.; Horowitz, N. H.; Hobby, G. L.; Levin, G. V.; Straat, P. A.; Lederberg, J.; Rich, A.; Hubbard, J. S.

1976-01-01

A preliminary progress report is presented for the Viking biological investigation through its first month. The carbon assimilation, gas exchange, and labeled release experiments are described in detail, and the chronology of the experiments is outlined. For the first experiment, it is found that a small amount of gas was converted into organic material in one sample and that heat treatment of a duplicate sample prevented such conversion. In the second experiment, a substantial amount of O2 was detected along with significant increases in CO2 and small changes in N2. In the third experiment, a significant amount of radioactive gas was evolved from one sample, but not from a duplicate heat-treated sample. Possible biological and nonbiological interpretations are considered for these results. It is concluded that while the experiments provide clear evidence for the occurrence of chemical reactions and while the results do not violate any prima facie criteria for biological processes, a definitive answer cannot yet be given to the question of whether life exists on Mars.

Chronic Disease Management Strategies of Early Childhood Caries: Support from the Medical and Dental Literature.

PubMed

Edelstein, Burton L; Ng, Man Wai

2015-01-01

An Institute of Medicine report places chronic disease management (CDM) as an intervention on a treatment spectrum between prevention and acute care. CDM commonly focuses on conditions in which patient self-care efforts are significant. Framing early childhood caries (ECC) as such a chronic condition invites dentistry to reconsider its approach to caries management and shift gears from a strictly surgical approach to one that also incorporates a medical approach. This paper's purpose was to explore the definition of and concepts inherent in CDM. An explanatory model is introduced to describe the multiple factors that influence ECC-CDM strategies. Reviewed literature suggests that early evidence from ECC-CDM interventions, along with results of pediatric asthma and diabetes CDM, supports CDM of ECC as a valid approach that is independent of both prevention and repair. Early results of ECC-CDM endeavors have demonstrated a reduction in rates of new cavitation, dental pain, and referral to the operating room compared to baseline rates. ECC-CDM strategies hold strong promise to curtail caries activity while complementing dental repair when needed, thereby reducing disease progression and cavity recurrence. Institutionalizing ECC-CDM will both require and benefit from evolving health care delivery and financing systems that reward positive health outcomes.

A divergence-cleaning scheme for cosmological SPMHD simulations

NASA Astrophysics Data System (ADS)

Stasyszyn, F. A.; Dolag, K.; Beck, A. M.

2013-01-01

In magnetohydrodynamics (MHD), the magnetic field is evolved by the induction equation and coupled to the gas dynamics by the Lorentz force. We perform numerical smoothed particle magnetohydrodynamics (SPMHD) simulations and study the influence of a numerical magnetic divergence. For instabilities arising from {nabla }\\cdot {boldsymbol B} related errors, we find the hyperbolic/parabolic cleaning scheme suggested by Dedner et al. to give good results and prevent numerical artefacts from growing. Additionally, we demonstrate that certain current SPMHD implementations of magnetic field regularizations give rise to unphysical instabilities in long-time simulations. We also find this effect when employing Euler potentials (divergenceless by definition), which are not able to follow the winding-up process of magnetic field lines properly. Furthermore, we present cosmological simulations of galaxy cluster formation at extremely high resolution including the evolution of magnetic fields. We show synthetic Faraday rotation maps and derive structure functions to compare them with observations. Comparing all the simulations with and without divergence cleaning, we are able to confirm the results of previous simulations performed with the standard implementation of MHD in SPMHD at normal resolution. However, at extremely high resolution, a cleaning scheme is needed to prevent the growth of numerical {nabla }\\cdot {boldsymbol B} errors at small scales.

Cyanobacteria HABs - Causes, Prevention, and Mitigation Workgroup Report.

USDA-ARS?s Scientific Manuscript database

Cyanobacteria (blue-green algae) are estimated to have evolved 3.5 billion years ago, at which time they began to add oxygen to the existing anaerobic atmosphere, actually changing the chemistry of the planet and allowing new life forms to evolve. These ubiquitous microbes are capable of tolerating ...

28 CFR 29.2 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Administration DEPARTMENT OF JUSTICE MOTOR VEHICLE THEFT PREVENTION ACT REGULATIONS § 29.2 Definitions. For the purposes of this part: (a) The Act or the MVTPA means the Motor Vehicle Theft Prevention Act. (b) Owner... used automobile dealerships. (c) The Program refers to the National Voluntary Motor Vehicle Theft...

78 FR 12702 - Control of Communicable Diseases: Interstate; Scope and Definitions

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-25

... Control of Communicable Diseases: Interstate; Scope and Definitions AGENCY: Centers for Disease Control... rulemaking; withdrawal. SUMMARY: The Centers for Disease Control and Prevention (CDC) within the Department.... Marrone, JD, Centers for Disease Control and Prevention, 1600 Clifton Road NE., Mailstop E-03, Atlanta...

Planning Sustainable Land-Use: The Experience Of Stella, Missouri

EPA Science Inventory

Sustainability has numerous definitions and is often discussed. However, there are fewer lessons derived from its application. The concept for its application evolved out of a study to determine whether brownfields could be redeveloped to be more environmentally friendly. The ...

47 CFR 0.466 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-10-01

... institution of graduate higher education, an institution of professional education and an institution of vocational education, which operates a program or programs of scholarly research. (6) The term non-commercial...-inclusive. Moreover, as methods of news delivery evolve (for example, the adoption of electronic...

12 CFR 1402.20 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-01-01

... secondary school, an institution of undergraduate higher education, an institution of graduate higher education, an institution of professional education, and an institution of vocational education that... examples are not intended to be all-inclusive. As traditional methods of news delivery evolve (e.g...

47 CFR 0.466 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-10-01

... institution of graduate higher education, an institution of professional education and an institution of vocational education, which operates a program or programs of scholarly research. (6) The term non-commercial...-inclusive. Moreover, as methods of news delivery evolve (for example, the adoption of electronic...

12 CFR 1402.20 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-01-01

... secondary school, an institution of undergraduate higher education, an institution of graduate higher education, an institution of professional education, and an institution of vocational education that... examples are not intended to be all-inclusive. As traditional methods of news delivery evolve (e.g...

40 CFR 35.343 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-07-01

... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS AND OTHER FEDERAL ASSISTANCE STATE AND LOCAL ASSISTANCE Environmental Program Grants Pollution Prevention State Grants (section 6605) § 35.343 Definitions. In addition to the definitions in § 35.102, the following definitions apply to the Pollution...

40 CFR 35.343 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-07-01

... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS AND OTHER FEDERAL ASSISTANCE STATE AND LOCAL ASSISTANCE Environmental Program Grants Pollution Prevention State Grants (section 6605) § 35.343 Definitions. In addition to the definitions in § 35.102, the following definitions apply to the Pollution...

To be or not to be alive: How recent discoveries challenge the traditional definitions of viruses and life.

PubMed

Forterre, Patrick

2016-10-01

Three major discoveries have recently profoundly modified our perception of the viral world: molecular ecologists have shown that viral particles are more abundant than cells in natural environments; structural biologists have shown that some viruses from the three domains of life, Bacteria, Eukarya and Archaea, are evolutionarily related, and microbiologists have discovered giant viruses that rival with cells in terms of size and gene content. I discuss here the scientific and philosophical impact of these discoveries on the debates over the definition, nature (living or not), and origin of viruses. I suggest that viruses have often been considered non-living, because they are traditionally assimilated to their virions. However, the term virus describes a biological process and should integrate all aspects of the viral reproduction cycle. It is especially important to focus on the intracellular part of this cycle, the virocell, when viral information is actively expressed and reproduced, allowing the emergence of new viral genes. The virocell concept theoretically removes roadblocks that prevent defining viruses as living organisms. However, defining a "living organism" remains challenging, as indicated by the case of organelles that evolved from intracellular bacteria. To bypass this problem, I suggest considering that all biological entities that actively participate in the process of life are living. Copyright © 2016. Published by Elsevier Ltd.

Pressure ulcers: Back to the basics

PubMed Central

Agrawal, Karoon; Chauhan, Neha

2012-01-01

Pressure ulcer in an otherwise sick patient is a matter of concern for the care givers as well as the medical personnel. A lot has been done to understand the disease process. So much so that USA and European countries have established advisory panels in their respective continents. Since the establishment of these organizations, the understanding of the pressure ulcer has improved significantly. The authors feel that the well documented and well publicized definition of pressure ulcer is somewhat lacking in the correct description of the disease process. Hence, a modified definition has been presented. This disease is here to stay. In the process of managing these ulcers the basic pathology needs to be understood well. Pressure ischemia is the main reason behind the occurrence of ulceration. Different extrinsic and intrinsic factors have been described in detail with review of literature. There are a large number of risk factors causing ulceration. The risk assessment scales have eluded the surgical literature and mostly remained in nursing books and websites. These scales have been reproduced for completion of the basics on decubitus ulcer. The classification of the pressure sores has been given in a comparative form to elucidate that most of the classifications are the same except for minor variations. The management of these ulcers is ever evolving but the age old saying of “prevention is better than cure” suits this condition the most. PMID:23162223

45 CFR 1340.13 - Approval of applications.

Code of Federal Regulations, 2010 CFR

2010-10-01

..., DEPARTMENT OF HEALTH AND HUMAN SERVICES THE ADMINISTRATION FOR CHILDREN, YOUTH AND FAMILIES, CHILD ABUSE AND NEGLECT PREVENTION AND TREATMENT PROGRAM CHILD ABUSE AND NEGLECT PREVENTION AND TREATMENT Grants to States...) with regard to the definition of “sexual abuse” (see § 1340.2(d)(1)) and the definitional requirement...

78 FR 12702 - Control of Communicable Diseases: Foreign; Scope and Definitions

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-25

... Control of Communicable Diseases: Foreign; Scope and Definitions AGENCY: Centers for Disease Control and...; withdrawal. SUMMARY: The Centers for Disease Control and Prevention (CDC) within the Department of Health and... Disease Control and Prevention, 1600 Clifton Road NE., Mailstop E-03, Atlanta, Georgia 30333; telephone...

Mapping the maze of terms and definitions in dementia-related wandering.

PubMed

Algase, D L; Moore, D Helen; Vandeweerd, C; Gavin-Dreschnack, D J

2007-11-01

An operational definition of dementia-related wandering is proposed to aid in clinical recognition, to promote research precision and validity, and to provide a pathway toward standardization of language in wandering science. (1) One-hundred-and-eighty-three journal articles from multiple databases (Medline, OVID, CSA Journals, OCLC First Search, Google Scholar, PubMed, EBSCO) were reviewed to extract alternative terms and definitions for wandering or wandering-related behaviours; (2) terms and definitions were ordered alphabetically into a glossary; (3) a consensus approach was used to group glossary terms with related meanings into possible domains of wandering; (4) four domains (locomotion, drive, space and time) were found sufficient to encompass all wandering definitions; (5) wandering terms were placed into a conceptual map bounded by the four domain concepts and (6) a new provisional definition of wandering was formulated. An empirically-based, operational definition improves clinical and research approaches to wandering and explicates historical inattention to certain beneficial aspects of the behaviour. Adoption of the proposed operational definition of wandering behaviour provides a platform upon which dementia care may be improved and standardized language may evolve in wandering science.

Ecological restoration should be redefined for the twenty-first century.

PubMed

Martin, David M

2017-09-24

Forty years ago, ecological restoration was conceptualized through a natural science lens. Today, ecological restoration has evolved into a social and scientific concept. The duality of ecological restoration is acknowledged in guidance documents on the subject but is not apparent in its definition. Current definitions reflect our views about what ecological restoration does but not why we do it. This viewpoint does not give appropriate credit to contributions from social sciences, nor does it provide compelling goals for people with different motivating rationales to engage in or support restoration. In this study, I give a concise history of the conceptualization and definition of ecological restoration, and I propose an alternative definition and corresponding viewpoint on restoration goal-setting to meet twenty-first century scientific and public inquiry.

36 CFR 1120.2 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-07-01

... graduate higher education, an institution of undergraduate higher education, an institution of professional education, and an institution of vocational education, which operates a program or programs of scholarly... examples are not intended to be all-inclusive. Moreover, as traditional methods of news delivery evolve (e...

36 CFR 1120.2 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-07-01

... graduate higher education, an institution of undergraduate higher education, an institution of professional education, and an institution of vocational education, which operates a program or programs of scholarly... examples are not intended to be all-inclusive. Moreover, as traditional methods of news delivery evolve (e...

Ventriculostomy-associated infection: a new, standardized reporting definition and institutional experience.

PubMed

Gozal, Yair M; Farley, Chad W; Hanseman, Dennis J; Harwell, Daniel; Magner, Mark; Andaluz, Norberto; Shutter, Lori

2014-08-01

Shortcomings created by the lack of both a uniform definition of ventriculostomy-associated infection (VAI) and reporting standards have led to widely ranging infections rates (2-24%) whose significance is uncertain. We propose a standardized definition of VAI and a consistent reporting format compliant with Centers for Disease Control and Prevention (CDC) for device-related infections. Using those parameters to establish an infection-control surveillance program, we report our 4-year institutional VAI rates. In this prospective study covering ventriculostomy utilization (October 2006-December 2010), 498 patients had a total of 4,673 ventriculostomy days. By review of the literature and our institutional analysis, we defined VAI as a positive CSF culture in a patient with ventriculostomy catheter, plus one or more of the following (1) fever recorded >101.5 °F or (2) cerebrospinal fluid (CSF) glucose level, either <50 mg/dL or <50% of a serum glucose level drawn within 24 h of the CSF glucose. In a report format that is CDC compliant, rates of VAI are reported. Among our patients, the CDC-compliant infection rate was 2.14 per 1,000 ventriculostomy days. Of the 10 VAIs occurring in 498 patients during 4,673 ventriculostomy days, this 2.0% infection rate was lower than the previously reported 8.8% composite rates of VAI. Average duration of ventriculostomy was 9.4 days. Neither antibiotic-impregnated catheters nor periprocedural or prophylactic antibiotics were used. Our standardized VAI definition and CDC format seems promising toward facilitating future study and guideline development. Given our strict protocol of sterile catheter placement and care, and our institution's low 2.0% infection rates, we propose an infection-rate target of ≤5 per 1,000 device days. Our results suggest that the use of antibiotics or antibiotic-impregnated catheters is unwarranted--a positive given concerns of evolving anti-microbial resistance.

21 CFR 312.32 - IND safety reports.

Code of Federal Regulations, 2010 CFR

2010-04-01

... safety reports. (a) Definitions. The following definitions of terms apply to this section:- Associated... intervention to prevent one of the outcomes listed in this definition. Examples of such medical events include... example, under this definition, hepatic necrosis would be unexpected (by virtue of greater severity) if...

44 CFR 151.03 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 44 Emergency Management and Assistance 1 2012-10-01 2011-10-01 true Definitions. 151.03 Section 151.03 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND..., Scope, Definitions § 151.03 Definitions. (a) The Act means the Federal Fire Prevention and Control Act...

44 CFR 151.03 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 44 Emergency Management and Assistance 1 2014-10-01 2014-10-01 false Definitions. 151.03 Section 151.03 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND..., Scope, Definitions § 151.03 Definitions. (a) The Act means the Federal Fire Prevention and Control Act...

44 CFR 151.03 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 44 Emergency Management and Assistance 1 2013-10-01 2013-10-01 false Definitions. 151.03 Section 151.03 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND..., Scope, Definitions § 151.03 Definitions. (a) The Act means the Federal Fire Prevention and Control Act...

44 CFR 151.03 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 44 Emergency Management and Assistance 1 2011-10-01 2011-10-01 false Definitions. 151.03 Section 151.03 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND..., Scope, Definitions § 151.03 Definitions. (a) The Act means the Federal Fire Prevention and Control Act...

44 CFR 151.03 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Definitions. 151.03 Section 151.03 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND..., Scope, Definitions § 151.03 Definitions. (a) The Act means the Federal Fire Prevention and Control Act...

Ethnic-Specific Criteria for Classification of Body Mass Index: A Perspective for Asian Indians and American Diabetes Association Position Statement.

PubMed

Misra, Anoop

2015-09-01

Definitions for overweight and obesity are universally applied using body mass index (BMI), based on morbidity and mortality data derived from white populations. However, several studies have shown higher body fat, excess metabolic perturbations, and cardiovascular risk factors at lower value of BMI in Asian versus white populations. Definitive guidelines have been published to classify a BMI of ≥23 kg/m(2) and ≥25 kg/m(2) as overweight and obese, respectively, by the Indian Consensus Group (for Asian Indians residing in India) and a BMI of ≥23 kg/m(2) for screening for diabetes by the National Institute of Health and Care Excellence of the United Kingdom (for migrant south Asians) and, in an encouraging initiative recently (2015), by the American Diabetes Association (for all Asian ethnic groups in the United States). Overall, multiple studies, and now several guidelines, emphasize early intervention with diet and physical activity in Asian ethnic groups for prevention and management of obesity-related noncommunicable diseases. By application of these guidelines, an additional 10-15% of the population in India would be labeled as overweight/obese, and more South Asians/Asians will be diagnosed with diabetes in the United Kingdom and the United States. Additional health resources need to be allocated to deal with increasing numbers of Asians with obesity-related noncommunicable diseases, and research is needed to evolve cost-effective interventions. Finally, consensus based on data is needed so that the World Health Organization and other international agencies could take definitive steps for revision of classification of BMI for Asian populations globally.

Child Maltreatment Prevention

MedlinePlus

... Prevention Strategies Additional Resources Data & Statistics Coping with stress Youth Violence Definitions Data Sources Risk and Protective Factors Consequences Prevention Strategies Environmental Design Additional Resources School- ...

The Zika virus and pregnancy: evidence, management, and prevention.

PubMed

Citil Dogan, Ayse; Wayne, Sandra; Bauer, Samuel; Ogunyemi, Dotun; Kulkharni, Santosh K; Maulik, Devika; Carpenter, Christopher F; Bahado-Singh, Ray O

2017-02-01

To comprehensively review the available evidence and existing consensus reports and guidelines regarding the pregnancy and reproductive implications of the mosquito-transmitted Zika virus (ZIKV) infection. A primary focus was to provide pertinent information to aid clinicians in the management of pregnancies at risk for, exposed to, or with confirmed ZIKV infection. An extensive literature review was performed using Pubmed. Practice guidelines and consensus reports were accessed from international, national, and professional organizations' websites. The clinical articles for ZIKV infection testing varied from case reports to small epidemiologic studies. A ZIKV epidemic has been declared in several countries in the Americas. Fifty-two travel-associated ZIKV infection cases have been reported throughout the USA (as of February 10, 2016). The consequences of congenital fetal/newborn ZIKV infection could potentially have devastating consequences including miscarriage, fetal death, and major anomalies such as microcephaly, brain and brain-stem defects, and long-term neurologic sequelae. While not definitive, current evidence suggests the existence of nonvector-borne transmission through sexual activity with an infected male partner. For women at risk for sexual transmission, condom use is advised, especially during pregnancy. While ZIKV infection appears to be a mild disease in the general population the potential consequences to the fetus and newborn could be profound. Management guidelines are currently evolving and will be significantly impacted as new evidence develops. It is therefore imperative that obstetric health-care providers keep abreast of this rapidly evolving information landscape that has so far characterized this outbreak.

Records as Genre.

ERIC Educational Resources Information Center

Schryer, Catherine F.

1993-01-01

Reworks the concept of genre from rhetorical, dialectical, and dialogic perspectives. Redefines genre as a stabilized-for-now site of social and ideological action. Applies this definition (in a six-month ethnographic study) to a specific literary practice--medical record keeping--evolving in a specific context--a veterinary college. (SR)

5 CFR 1303.30 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-01-01

... education, an institution of undergraduate higher education, an institution of professional education, or an institution of vocational education, that operates a program or programs of scholarly research. (i) The term... examples are not intended to be all-inclusive. Moreover, as traditional methods of news delivery evolve (e...

Identifying and exploiting genes that potentiate the evolution of antibiotic resistance.

PubMed

Gifford, Danna R; Furió, Victoria; Papkou, Andrei; Vogwill, Tom; Oliver, Antonio; MacLean, R Craig

2018-06-01

There is an urgent need to develop novel approaches for predicting and preventing the evolution of antibiotic resistance. Here, we show that the ability to evolve de novo resistance to a clinically important β-lactam antibiotic, ceftazidime, varies drastically across the genus Pseudomonas. This variation arises because strains possessing the ampR global transcriptional regulator evolve resistance at a high rate. This does not arise because of mutations in ampR. Instead, this regulator potentiates evolution by allowing mutations in conserved peptidoglycan biosynthesis genes to induce high levels of β-lactamase expression. Crucially, blocking this evolutionary pathway by co-administering ceftazidime with the β-lactamase inhibitor avibactam can be used to eliminate pathogenic P. aeruginosa populations before they can evolve resistance. In summary, our study shows that identifying potentiator genes that act as evolutionary catalysts can be used to both predict and prevent the evolution of antibiotic resistance.

The Evolution of the Placenta

PubMed Central

Roberts, R Michael; Green, Jonathan A; Schulz, Laura C

2016-01-01

The still apt definition of a placenta is that coined by Mossman, namely apposition or fusion of the fetal membranes to the uterine mucosa for physiological exchange. As such it is a specialized organ whose purpose is to provide continuing support to the developing young. By this definition, placentas have evolved within every vertebrate class other than birds. They have evolved on multiple occasions, often within quite narrow taxonomic groups. As the placenta and the maternal system associate more intimately, such that the conceptus relies extensively on maternal support, the relationship leads to increased conflict that drives adaptive changes on both sides. The story of vertebrate placentation, therefore, is one of convergent evolution at both the macro- and molecular levels. In this short review, we first describe the emergence of placental-like structures in non-mammalian vertebrates and then transition to mammals themselves. We close the review by discussing mechanisms that might have favored diversity and hence evolution of the morphology and physiology of the placentas of eutherian mammals. PMID:27486265

A Practical Measure for the Complexity of Evolving Seismicity Patterns

NASA Astrophysics Data System (ADS)

Goltz, C.

2005-12-01

Earthquakes are a "complex" phenomenon. There is, however, no clear definition of what complexity actually is. Yet, it is important to distinguish between what is merely complicated and what is complex in the sense that simple rules can give rise to very rich behaviour. Seismicity is certainly a complicated phenomenon (difficult to understand) but simple models such as cellular automata indicate that earthquakes are truly complex. From the observational point of view, there exists the problem of quantification of complexity in real world seismicity patterns. Such a measurement is desirable, not only for fundamental understanding but also for monitoring and possibly for forecasting. Maybe the most workable definitions of complexity exist in informatics, summarised under the topic of algorithmic complexity. Here, after introducing the concepts, I apply such a measure of complexity to temporally evolving real-world seismicity patterns. Finally, I discuss the usefulness of the approach and regard the results in view of the occurrence of large earthquakes.

29 CFR 1910.34 - Coverage and definitions.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 29 Labor 5 2011-07-01 2011-07-01 false Coverage and definitions. 1910.34 Section 1910.34 Labor... OCCUPATIONAL SAFETY AND HEALTH STANDARDS Means of Egress § 1910.34 Coverage and definitions. (a) Every employer... the minimum requirements for emergency action plans and fire prevention plans. (c) Definitions...

29 CFR 1910.34 - Coverage and definitions.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 29 Labor 5 2010-07-01 2010-07-01 false Coverage and definitions. 1910.34 Section 1910.34 Labor... OCCUPATIONAL SAFETY AND HEALTH STANDARDS Means of Egress § 1910.34 Coverage and definitions. (a) Every employer... the minimum requirements for emergency action plans and fire prevention plans. (c) Definitions...

Principles of definitive soft tissue coverage with flaps.

PubMed

Levin, L Scott

2008-01-01

Despite the emergence of negative pressure wound therapy with reticulated open cell foam (NPWT/ROCF) as delivered by V.A.C.(R) Therapy (KCI, San Antonio, TX) for orthopaedic trauma, vascularized tissue transfer whether it be pedicle, free, or tissue transfer using the operating microscope or as an island, remains the mainstay of soft tissue reconstruction for orthopaedic traumatology. The critisism of microvascular procedures has been that they are lengthy, costly, and required technical expertise to perform. While technical skills are required, microsurgical care has evolved into a routine operation with high degrees of success in experienced hand. The problem that still remains is access to surgeons who are interested in soft tissue reconstruction and can perform definitive coverage with flaps. There is a need in the orthopaedic community to solve the problem of lack of flap surgeons and as a result, NPWT/ROCF has been touted as the answer to flap reconstruction. NPWT/ROCF is an important addition to soft tissue reconstruction but it serves as a bridge rather than definitive coverage in many hands. Just as wound technology is evolving with tissue substitutes, growth factors and NPWT/ROCF flaps technology continues to advance with new perforator flaps and local regional flaps, particularly the sural flap, coming on line as mainstays of soft tissue reconstruction.

Exploration Supply Chain Simulation

NASA Technical Reports Server (NTRS)

2008-01-01

The Exploration Supply Chain Simulation project was chartered by the NASA Exploration Systems Mission Directorate to develop a software tool, with proper data, to quantitatively analyze supply chains for future program planning. This tool is a discrete-event simulation that uses the basic supply chain concepts of planning, sourcing, making, delivering, and returning. This supply chain perspective is combined with other discrete or continuous simulation factors. Discrete resource events (such as launch or delivery reviews) are represented as organizational functional units. Continuous resources (such as civil service or contractor program functions) are defined as enabling functional units. Concepts of fixed and variable costs are included in the model to allow the discrete events to interact with cost calculations. The definition file is intrinsic to the model, but a blank start can be initiated at any time. The current definition file is an Orion Ares I crew launch vehicle. Parameters stretch from Kennedy Space Center across and into other program entities (Michaud Assembly Facility, Aliant Techsystems, Stennis Space Center, Johnson Space Center, etc.) though these will only gain detail as the file continues to evolve. The Orion Ares I file definition in the tool continues to evolve, and analysis from this tool is expected in 2008. This is the first application of such business-driven modeling to a NASA/government-- aerospace contractor endeavor.

Managed care. Shifts health care from an altruistic model to a business framework.

PubMed

Kersbergen, A L

2000-01-01

The term managed care, as used throughout the scientific and lay literature, has become a generic label without a clear, universally accepted definition. The many definitions and descriptions of managed care are usually directly related to the model under discussion. Nevertheless, as nurse educators attempt to align curricula with the evolving health care environment, it is imperative that students gain an understanding of the concept of managed care and the skills needed to practice in the managed care environment. Schools of nursing must prepare students to deal with the consequences of managed care, namely, the changing base of power, conflicts, and ethical dilemmas across settings. The drive to control health care costs in the 1990s brought about unprecedented change for nurses. Regardless of the strategies implemented in the name of managing care, the evolving health care environment has changed where and how nurses practice. To aid faculty in the revision of the nursing curriculum, an attempt was made to arrive at an empirically based definition of managed care that will provide a conceptual foundation for future research and theoretical discussions. Other goals were to identify consequences of managed care across disciplines and models implemented in the name of managing care, and to identify skills needed by nurses today.

Surgical timing of treating injured extremities: an evolving concept of urgency.

PubMed

Crist, Brett D; Ferguson, Tania; Murtha, Yvonne M; Lee, Mark A

2013-01-01

The management of some orthopaedic extremity injuries has changed over the past decade because of changing resource availability and the risks of complications. It is helpful to review the current literature regarding orthopaedic extremity emergencies and urgencies. The effects of the techniques of damage control orthopaedic techniques and the concept of the orthopaedic trauma room have also affected the management of these injuries. The available literature indicates that the remaining true orthopaedic extremity emergencies include compartment syndrome and vascular injuries associated with fractures and dislocations. Orthopaedic urgencies include open fracture management, femoral neck fractures in young patients treated with open reduction and internal fixation, and talus fractures that are open or those with impending skin compromise. Deciding when the definitive management of orthopaedic extremity injuries will occur has evolved as the concept of damage control orthopaedics has become more commonly accepted. Patient survival rates have improved with current resuscitative protocols. Definitive fixation of extremity injuries should be delayed until the patient's physiologic and extremity soft-tissue status allows for appropriate definitive management while minimizing the risks of complications. In patients with semiurgent orthopaedic injuries, the use of an orthopaedic trauma room has led to more efficient care of patients, fewer complications, and better time management for surgeons who perform on-call service for patients with traumatic orthopaedic injuries.

Quaternary prevention: reviewing the concept.

PubMed

Martins, Carlos; Godycki-Cwirko, Maciek; Heleno, Bruno; Brodersen, John

2018-12-01

According to the Wonca International Dictionary for General/Family Practice Quaternary Prevention is defined as: 'Action taken to identify patient at risk of overmedicalization, to protect him from new medical invasion, and to suggest to him interventions, which are ethically acceptable.' The concept of quaternary prevention was initially proposed by Marc Jamoulle and the targets were mainly patients with illness but without a disease. The purpose of this opinion article is to open the debate around a new possible definition and a new conceptual model of quaternary prevention based on the belief that quaternary prevention should be present in physicians' minds for every intervention they suggest to a patient. The debate around quaternary prevention is vital in the context of contemporary medicine and has expanded worldwide. The human being may suffer harm from medical interventions from conception, during their childhood, during their entire healthy lifetime as well as during a self-limited disease, a chronic disease, or a terminal disease. The current definition of quaternary prevention has limitations because it excludes patients and medical interventions where a quaternary prevention perspective would be needed and useful to protect patients from harm. In this context, a new definition and conceptual model of quaternary prevention is proposed. In this new proposal, quaternary prevention is defined as an 'action taken to protect individuals (persons/patients) from medical interventions that are likely to cause more harm than good.'

Developing a new national approach to surveillance for ventilator-associated events: executive summary.

PubMed

Magill, Shelley S; Klompas, Michael; Balk, Robert; Burns, Suzanne M; Deutschman, Clifford S; Diekema, Daniel; Fridkin, Scott; Greene, Linda; Guh, Alice; Gutterman, David; Hammer, Beth; Henderson, David; Hess, Dean R; Hill, Nicholas S; Horan, Teresa; Kollef, Marin; Levy, Mitchell; Septimus, Edward; VanAntwerpen, Carole; Wright, Don; Lipsett, Pamela

2013-11-01

In September 2011, the Centers for Disease Control and Prevention (CDC) convened a Ventilator-Associated Pneumonia (VAP) Surveillance Definition Working Group to organize a formal process for leaders and experts of key stakeholder organizations to discuss the challenges of VAP surveillance definitions and to propose new approaches to VAP surveillance in adult patients (Table 1). The charges to the Working Group were to (1) critically review a draft, streamlined VAP surveillance definition developed for use in adult patients; (2) suggest modifications to enhance the reliability and credibility of the surveillance definition within the critical care and infection prevention communities; and (3) propose a final adult surveillance definition algorithm to be implemented in the CDC's National Healthcare Safety Network (NHSN), taking into consideration the potential future use of the definition algorithm in public reporting, interfacility comparisons, and pay-for-reporting and pay-for-performance programs. Published by Mosby, Inc.

Stepping stones towards a new prokaryotic taxonomy.

PubMed

Gevers, Dirk; Dawyndt, Peter; Vandamme, Peter; Willems, Anne; Vancanneyt, Marc; Swings, Jean; De Vos, Paul

2006-11-29

Technological developments provide new insights into prokaryotic evolution and diversity and provoke a continuous need to update taxonomy and revise classification schemes. Our present species concept and definition are being challenged by the growing amount of whole genomic information, which should allow improvements in the natural species definition. The continuous quest for an objective and stable method for sorting strains into coherent homogeneous groups is inherent to prokaryotic systematics and nomenclature. Morphological, biochemical, physiological, phenotypic and chemotaxonomic criteria have been complemented by molecular data and pragmatic, purpose built, species definitions are being replaced by more natural ones based on evolutionary insights. It is imperative to give due consideration to both fundamental and applied aspects of future species concepts and definitions. The present paper discusses the present practice in prokaryotic taxonomy of how this system developed and how it may evolve in the future.

33 CFR 151.3000 - Definition of marine debris for the purposes of the Marine Debris Research, Prevention, and...

Code of Federal Regulations, 2011 CFR

2011-07-01

... 33 Navigation and Navigable Waters 2 2011-07-01 2011-07-01 false Definition of marine debris for the purposes of the Marine Debris Research, Prevention, and Reduction Act. 151.3000 Section 151.3000... CARRYING OIL, NOXIOUS LIQUID SUBSTANCES, GARBAGE, MUNICIPAL OR COMMERCIAL WASTE, AND BALLAST WATER...

33 CFR 151.3000 - Definition of marine debris for the purposes of the Marine Debris Research, Prevention, and...

Code of Federal Regulations, 2010 CFR

2010-07-01

... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Definition of marine debris for the purposes of the Marine Debris Research, Prevention, and Reduction Act. 151.3000 Section 151.3000... CARRYING OIL, NOXIOUS LIQUID SUBSTANCES, GARBAGE, MUNICIPAL OR COMMERCIAL WASTE, AND BALLAST WATER...

Understanding Multicultural Education: Equity for All Students

ERIC Educational Resources Information Center

Rios, Francisco; Stanton, Christine Rogers

2011-01-01

Multicultural education has evolved over the last 25 years to become a promising, productive, and positive approach to education within an increasingly diverse schooling context. The academic discipline has developed models, robust definitions and goals, and specific pedagogical principles related to an education that is multicultural. Almost all…

Empathy

ERIC Educational Resources Information Center

Palmer, Jordan

2018-01-01

Empathy is a hotly contested keyword for educational purposes, with the field of counseling recording over 27 different definitions. The term has its roots in aesthetic appreciation of artistic endeavour, although it has evolved into an appreciation of matters from another's perspective. As such, it is a powerful tool for anti-bullying and…

Identifying Specific Learning Disabilities: Legislation, Regulation, and Court Decisions

ERIC Educational Resources Information Center

Zumeta, Rebecca O.; Zirkel, Perry A.; Danielson, Louis

2014-01-01

Specific learning disability (SLD) identification and eligibility practices are evolving and sometimes contentious. This article describes the historical context and current status of the SLD definition, legislation, regulation, and case law related to the identification of students eligible for special education services. The first part traces…

Culturally Considerate School Counseling: Helping without Bias

ERIC Educational Resources Information Center

Anderson, Kim L.

2010-01-01

The author brings her counseling expertise, personal experience, and compassionate perspective to this practical resource that cultivates "cultural competence"--essential for work with diverse populations. Expanding the definition of culture, this book addresses how biases have evolved in new and challenging ways, and provides strategies to help…

World Class Schools: An Evolving Concept.

ERIC Educational Resources Information Center

Jenkins, John M., Ed.; And Others

The concept of "world class," often used in reference to education, lacks a precise, universal definition. This book presents case studies of exemplary schools. The foreword by Fenwick W. English presents a developmental concept of world-class education, in which fair and comparable standards, with sufficient room for sociocultural…

Mythic Evolution of "The New Frontier" in Mass Mediated Rhetoric.

ERIC Educational Resources Information Center

Rushing, Janice Hocker

1986-01-01

Combines "rhetorical narration" with K. Burke's dramatistic pentad to argue that definitional cultural myths are rhetorically meaningful in relation to social consciousness if both evolved teleologically. Delineates two phases in America's frontier myth associated with recent space fiction films' representation of a pentadic term's…

Definitions and methods of measuring and reporting on injurious falls in randomised controlled fall prevention trials: a systematic review

PubMed Central

2012-01-01

Background The standardisation of the assessment methodology and case definition represents a major precondition for the comparison of study results and the conduction of meta-analyses. International guidelines provide recommendations for the standardisation of falls methodology; however, injurious falls have not been targeted. The aim of the present article was to review systematically the range of case definitions and methods used to measure and report on injurious falls in randomised controlled trials (RCTs) on fall prevention. Methods An electronic literature search of selected comprehensive databases was performed to identify injurious falls definitions in published trials. Inclusion criteria were: RCTs on falls prevention published in English, study population ≥ 65 years, definition of injurious falls as a study endpoint by using the terms "injuries" and "falls". Results The search yielded 2089 articles, 2048 were excluded according to defined inclusion criteria. Forty-one articles were included. The systematic analysis of the methodology applied in RCTs disclosed substantial variations in the definition and methods used to measure and document injurious falls. The limited standardisation hampered comparability of study results. Our results also highlight that studies which used a similar, standardised definition of injurious falls showed comparable outcomes. Conclusions No standard for defining, measuring, and documenting injurious falls could be identified among published RCTs. A standardised injurious falls definition enhances the comparability of study results as demonstrated by a subgroup of RCTs used a similar definition. Recommendations for standardising the methodology are given in the present review. PMID:22510239

49 CFR 543.4 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 49 Transportation 6 2010-10-01 2010-10-01 false Definitions. 543.4 Section 543.4 Transportation Other Regulations Relating to Transportation (Continued) NATIONAL HIGHWAY TRAFFIC SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EXEMPTION FROM VEHICLE THEFT PREVENTION STANDARD § 543.4 Definitions. (a...

Challenges in congenital syphilis surveillance: how are congenital syphilis investigations classified?

PubMed

Introcaso, Camille E; Gruber, DeAnn; Bradley, Heather; Peterman, Thomas A; Ewell, Joy; Wendell, Debbie; Foxhood, Joseph; Su, John R; Weinstock, Hillard S; Markowitz, Lauri E

2013-09-01

Congenital syphilis is a serious, preventable, and nationally notifiable disease. Despite the existence of a surveillance case definition, congenital syphilis is sometimes classified differently using an algorithm on the Centers for Disease Control and Prevention's case reporting form. We reviewed Louisiana's congenital syphilis electronic reporting system for investigations of infants born from January 2010 to October 2011, abstracted data required for classification, and applied the surveillance definition and the algorithm. We calculated the sensitivities and specificities of the algorithm and Louisiana's classification using the surveillance definition as the surveillance gold standard. Among 349 congenital syphilis investigations, the surveillance definition identified 62 cases. The algorithm had a sensitivity of 91.9% and a specificity of 64.1%. Louisiana's classification had a sensitivity of 50% and a specificity of 91.3% compared with the surveillance definition. The differences between the algorithm and the surveillance definition led to misclassification of congenital syphilis cases. The algorithm should match the surveillance definition. Other state and local health departments should assure that their reported cases meet the surveillance definition.

High definition systems in Japan

NASA Technical Reports Server (NTRS)

Elkus, Richard J., Jr.; Cohen, Robert B.; Dayton, Birney D.; Messerschmitt, David G.; Schreiber, William F.; Tannas, Lawrence E., Jr.; Shelton, Duane

1991-01-01

The successful implementation of a strategy to produce high-definition systems within the Japanese economy will favorably affect the fundamental competitiveness of Japan relative to the rest of the world. The development of an infrastructure necessary to support high-definition products and systems in that country involves major commitments of engineering resources, plants and equipment, educational programs and funding. The results of these efforts appear to affect virtually every aspect of the Japanese industrial complex. The results of assessments of the current progress of Japan toward the development of high-definition products and systems are presented. The assessments are based on the findings of a panel of U.S. experts made up of individuals from U.S. academia and industry, and derived from a study of the Japanese literature combined with visits to the primary relevant industrial laboratories and development agencies in Japan. Specific coverage includes an evaluation of progress in R&D for high-definition television (HDTV) displays that are evolving in Japan; high-definition standards and equipment development; Japanese intentions for the use of HDTV; economic evaluation of Japan's public policy initiatives in support of high-definition systems; management analysis of Japan's strategy of leverage with respect to high-definition products and systems.

Putting the Weather Back Into Climate

NASA Astrophysics Data System (ADS)

Smith, Leonard A.; Stainforth, David A.

2014-05-01

The literature contains a variety of definitions of climate, and the emphasis in these definitions has changed over time. Defining climate as a mean value is, of course, both limiting and misleading; definitions of climate based on averages have been deprecated as far back as 1931 [1]. In the context of current efforts to produce climate predictions for use in climate adaptation, it is timely to consider how well various definitions of climate serve the research for applications community. From a nonlinear dynamical systems perspective it is common to associate climate with a system's natural measure (or "attractor" if such an object exists). Such a definition is not easily applied to physical systems where we have limited observations over a restricted period of time; the duration of 30 years is often mentioned today and the origin of this period is discussed. Given a dynamic system in which parameters are evolving in time, the view of climate as a natural measure becomes problematic as, by definition, there may be no attractor per se. Attractors defined for particular parameter values cannot be expected to have any association with the probability of states under transient changes in the values of that parameter. Alternatively, distributions may be determined which reflect the transient situation, based on (rather broad) additional assumptions regarding the state of the system at some point in the past (say, an ice age planet vs an interglacial planet). Such distributions reflect many of the properties one would hope to be represented in a generalised definition of the system's climate. Here we trace how definitions of climate have changed over time and highlight a number of properties of definitions of climate which would facilitate common use across researchers, from observers to theoreticians, from climate modellers to mathematicians. We show while periodic changes in parameter values (such as those found in an annual cycle or a diurnal cycle) are easily incorporated within the traditional nonlinear dynamical systems view, non-periodic or secular changes (such as those due to increasing atmospheric greenhouse gas concentrations) yield an open challenge. We argue the need both for clarifying and for clearly meeting the open challenges of defining climate in relation to the state of an evolving system, and suggest a path forward. [1] Miller, A.A., 1931: Climatology. First Ed. Methuen.

Evolution and the complexity of bacteriophages.

PubMed

Serwer, Philip

2007-03-13

The genomes of both long-genome (> 200 Kb) bacteriophages and long-genome eukaryotic viruses have cellular gene homologs whose selective advantage is not explained. These homologs add genomic and possibly biochemical complexity. Understanding their significance requires a definition of complexity that is more biochemically oriented than past empirically based definitions. Initially, I propose two biochemistry-oriented definitions of complexity: either decreased randomness or increased encoded information that does not serve immediate needs. Then, I make the assumption that these two definitions are equivalent. This assumption and recent data lead to the following four-part hypothesis that explains the presence of cellular gene homologs in long bacteriophage genomes and also provides a pathway for complexity increases in prokaryotic cells: (1) Prokaryotes underwent evolutionary increases in biochemical complexity after the eukaryote/prokaryote splits. (2) Some of the complexity increases occurred via multi-step, weak selection that was both protected from strong selection and accelerated by embedding evolving cellular genes in the genomes of bacteriophages and, presumably, also archaeal viruses (first tier selection). (3) The mechanisms for retaining cellular genes in viral genomes evolved under additional, longer-term selection that was stronger (second tier selection). (4) The second tier selection was based on increased access by prokaryotic cells to improved biochemical systems. This access was achieved when DNA transfer moved to prokaryotic cells both the more evolved genes and their more competitive and complex biochemical systems. I propose testing this hypothesis by controlled evolution in microbial communities to (1) determine the effects of deleting individual cellular gene homologs on the growth and evolution of long genome bacteriophages and hosts, (2) find the environmental conditions that select for the presence of cellular gene homologs, (3) determine which, if any, bacteriophage genes were selected for maintaining the homologs and (4) determine the dynamics of homolog evolution. This hypothesis is an explanation of evolutionary leaps in general. If accurate, it will assist both understanding and influencing the evolution of microbes and their communities. Analysis of evolutionary complexity increase for at least prokaryotes should include analysis of genomes of long-genome bacteriophages.

Clinical Virtual Reality tools to advance the prevention, assessment, and treatment of PTSD.

PubMed

Rizzo, Albert 'Skip'; Shilling, Russell

2017-01-01

Numerous reports indicate that the incidence of posttraumatic stress disorder (PTSD) in Operation Enduring Freedom/Operation Iraqi Freedom/Operation New Dawn (OEF/OIF/OND) military personnel has created a significant behavioural healthcare challenge. These findings have served to motivate research on how to better develop and disseminate evidence-based treatments for PTSD. The current article presents the use of Virtual Reality (VR) as a clinical tool to address the assessment, prevention, and treatment of PTSD, based on the VR projects that were evolved at the University of Southern California Institute for Creative Technologies since 2004. A brief discussion of the definition and rationale for the clinical use of VR is followed by a description of a VR application designed for the delivery of prolonged exposure (PE) for treating Service Members (SMs) and Veterans with combat- and sexual assault-related PTSD. The expansion of the virtual treatment simulations of Iraq and Afghanistan for PTSD assessment and prevention is then presented. This is followed by a forward-looking discussion that details early efforts to develop virtual human agent systems that serve the role of virtual patients for training the next generation of clinical providers, as healthcare guides that can be used to support anonymous access to trauma-relevant behavioural healthcare information, and as clinical interviewers capable of automated behaviour analysis of users to infer psychological state. The paper will conclude with a discussion of VR as a tool for breaking down barriers to care in addition to its direct application in assessment and intervention.

Clinical Virtual Reality tools to advance the prevention, assessment, and treatment of PTSD

PubMed Central

Rizzo, Albert ‘Skip’; Shilling, Russell

2017-01-01

ABSTRACT Numerous reports indicate that the incidence of posttraumatic stress disorder (PTSD) in Operation Enduring Freedom/Operation Iraqi Freedom/Operation New Dawn (OEF/OIF/OND) military personnel has created a significant behavioural healthcare challenge. These findings have served to motivate research on how to better develop and disseminate evidence-based treatments for PTSD. The current article presents the use of Virtual Reality (VR) as a clinical tool to address the assessment, prevention, and treatment of PTSD, based on the VR projects that were evolved at the University of Southern California Institute for Creative Technologies since 2004. A brief discussion of the definition and rationale for the clinical use of VR is followed by a description of a VR application designed for the delivery of prolonged exposure (PE) for treating Service Members (SMs) and Veterans with combat- and sexual assault-related PTSD. The expansion of the virtual treatment simulations of Iraq and Afghanistan for PTSD assessment and prevention is then presented. This is followed by a forward-looking discussion that details early efforts to develop virtual human agent systems that serve the role of virtual patients for training the next generation of clinical providers, as healthcare guides that can be used to support anonymous access to trauma-relevant behavioural healthcare information, and as clinical interviewers capable of automated behaviour analysis of users to infer psychological state. The paper will conclude with a discussion of VR as a tool for breaking down barriers to care in addition to its direct application in assessment and intervention. PMID:29372007

Evaluating Organizational Performance: Rational, Natural, and Open System Models

ERIC Educational Resources Information Center

Martz, Wes

2013-01-01

As the definition of organization has evolved, so have the approaches used to evaluate organizational performance. During the past 60 years, organizational theorists and management scholars have developed a comprehensive line of thinking with respect to organizational assessment that serves to inform and be informed by the evaluation discipline.…

Metacognition: Transforming the Learning Experience

ERIC Educational Resources Information Center

Chekwa, Emmanuel; McFadden, Misty; Divine, Angelia; Dorius, Tina

2015-01-01

A simplistic definition of metacognition is "thinking about thinking." It involves taking time to analyze and delve into the various ways the mind receives and retains information. It is not a new concept but metacognition is evolving as a new word for successful learners. It is stimulating much conversation and excitement in academia as…

Metacognition: Transforming Learning Experience

ERIC Educational Resources Information Center

Chekwa, Emmanuel; McFadden, Misty; Divine, Angelia; Dorius, Tina

2014-01-01

A simplistic definition of metacognition is "thinking about thinking." It involves taking time to analyze and delve into the various ways the mind receives and retains information. It is not a new concept but metacognition is evolving as a new word for successful learners. It is stimulating much conversation and excitement in academia as…

History and Civility

ERIC Educational Resources Information Center

Schaefer, Larry

2015-01-01

Larry Schaefer's history of civility is a succinct summary of the implicit and evolving definitions of civility over 2500 years of civilization. Beginning with the Romans and the root word "civitas," meaning the rights and duties of citizenship, civility appears in classical literature as integral to the roots of democracy in the context…

Strength in the Face of Adversity: Resilience Strategies of Transgender Individuals

ERIC Educational Resources Information Center

Singh, Anneliese A.; Hays, Danica G.; Watson, Laurel S.

2011-01-01

This phenomenological inquiry explored the lived experiences of resilience of 21 transgender individuals. Through individual semistructured interviews (3 interviews each with 5 participants) and 1 focus group interview (16 participants), the authors identified 5 common resiliency themes (evolving a self-generated definition of self, embracing…

Sulfuric Acid and Water: Paradoxes of Dilution

ERIC Educational Resources Information Center

Leenson, I. A.

2004-01-01

On equilibrium properties of aqueous solutions of sulfuric acid, Julius Thomsen has marked that the heat evolved on diluting liquid sulfuric acid with water is a continuous function of the water used, and excluded absolutely the acceptance of definite hydrates as existing in the solution. Information about thermochemical measurement, a discussion…

Constant Change: The Ever-Evolving Personal Learning Environment

ERIC Educational Resources Information Center

Torres Kompen, Ricardo; Monguet, Josep Ma.; Brigos, Miguel

2015-01-01

There are several definitions for the term "personal learning environment" (PLE); in this article, PLE refers to a group of web technologies, with various degrees of integration and interaction, that helps users and learners manage the flow of information that relates to the learning process, the creation of knowledge, and the…

Internationalisation Discourse Hits the Tipping Point: A New Definition Is Needed

ERIC Educational Resources Information Center

Yemini, Miri

2015-01-01

The discourse on internationalisation has undergone a transformation in recent years, particularly in the sphere of education, where the term's centrality has long been undeniable. This discourse has evolved from a focus on internationalisation's increasing importance in education to a mounting critique regarding the process's utility and…

Negotiating Practice Research

ERIC Educational Resources Information Center

Julkunen, Ilse; Uggerhoj, Lars

2016-01-01

The complexity of carrying out practice research in social service organizations is often matched by the complexity of teaching future social work practitioners to use and engage in practice research. To appreciate the scope of the teaching challenge, it is important to reflect on the evolving definition of practice research and issues involved in…

75 FR 59173 - TRICARE: Elimination of Copayments for Authorized Preventive Services for Certain TRICARE...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-27

...'' section that are not truly preventive but are more evaluative in nature in the ``Special Benefit Information'' Section of 32 CFR 199.4(e) and add a definition of ``evaluative'' services in 32 CFR 199.2. VII...) is revised to add a definition for evaluative services. The purpose of this is to make a distinction...

Therapeutic Alliance: A Concept for the Childbearing Season

PubMed Central

Doherty, Mary Ellen

2009-01-01

This analysis was conducted to describe the concept of therapeutic alliance and its appropriateness for health-care provider-client interactions during the childbearing season. The concept has been defined in other disciplines. A universal definition suggested a merging of efforts directed toward health. A simple and concise definition evolved, which is applicable to the childbearing season as well as to health-care encounters across the life span. This definition states: Therapeutic alliance is a process within a health-care provider-client interaction that is initiated by an identified need for positive client health-care behaviors, whereby both parties work together toward this goal with consideration of the client's current health status and developmental stage within the life span. PMID:20514120

Space station data system analysis/architecture study. Task 3: Trade studies, DR-5, volume 1

NASA Technical Reports Server (NTRS)

1985-01-01

The primary objective of Task 3 is to provide additional analysis and insight necessary to support key design/programmatic decision for options quantification and selection for system definition. This includes: (1) the identification of key trade study topics; (2) the definition of a trade study procedure for each topic (issues to be resolved, key inputs, criteria/weighting, methodology); (3) conduct tradeoff and sensitivity analysis; and (4) the review/verification of results within the context of evolving system design and definition. The trade study topics addressed in this volume include space autonomy and function automation, software transportability, system network topology, communications standardization, onboard local area networking, distributed operating system, software configuration management, and the software development environment facility.

Postoperative ileus: Recent developments in pathophysiology and management.

PubMed

Bragg, Damian; El-Sharkawy, Ahmed M; Psaltis, Emmanouil; Maxwell-Armstrong, Charles A; Lobo, Dileep N

2015-06-01

Postoperative ileus (POI) is a frequent occurrence after abdominal and other types of surgery, and is associated with significant morbidity and costs to health care providers. The aims of this narrative review were to provide an update of classification systems, preventive techniques, pathophysiological mechanisms, and treatment options for established POI. The Web of Science, MEDLINE, PubMed and Google Scholar databases were searched using the key phrases 'ileus', 'postoperative ileus' and 'definition', for relevant studies published in English from January 1997 to August 2014. POI is still a problematic and frequent complication of surgery. Fluid overload, exogenous opioids, neurohormonal dysfunction, and gastrointestinal stretch and inflammation are key mechanisms in the pathophysiology of POI. Evidence is supportive of thoracic epidural analgesia, avoidance of salt and water overload, alvimopan and gum chewing as measures for the prevention of POI, and should be incorporated into perioperative care protocols. Minimal access surgery and avoidance of nasogastric tubes may also help. Novel strategies are emerging, but further studies are required for the treatment of prolonged POI, where evidence is still lacking. Although POI is often inevitable, methods to reduce its duration and facilitate recovery of postoperative gastrointestinal function are evolving rapidly. Utilisation of standardised diagnostic classification systems will help improve applicability of future studies. Copyright © 2015 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.

Conceptual definitions of indicators for the nursing outcome "Knowledge: Fall Prevention".

PubMed

Luzia, Melissa de Freitas; Argenta, Carla; Almeida, Miriam de Abreu; Lucena, Amália de Fátima

2018-01-01

to construct conceptual definitions for indicators of nursing outcome Knowledge: Fall Prevention, selected for evaluation of hospitalized patients with the nursing diagnosis Risk for falls. integrative literature review performed in the LILACS, MEDLINE and Web of Science databases, comprising articles published in English, Spanish and Portuguese languages from 2005 to 2015. the final sample of the study was composed of 17 articles. The conceptualizations were constructed for 14 indicators of nursing outcome Knowledge: Fall Prevention focused on hospitalized patients. the theoretical support of the Nursing Outcomes Classification (NOC), through the process of constructing the conceptual definitions of the indicators of its results, allows nurses to accurately implement this classification in clinical practice and to evaluate the effectiveness of their interventions through the change of the patients' status over time.

What is big data? A consensual definition and a review of key research topics

NASA Astrophysics Data System (ADS)

De Mauro, Andrea; Greco, Marco; Grimaldi, Michele

2015-02-01

Although Big Data is a trending buzzword in both academia and the industry, its meaning is still shrouded by much conceptual vagueness. The term is used to describe a wide range of concepts: from the technological ability to store, aggregate, and process data, to the cultural shift that is pervasively invading business and society, both drowning in information overload. The lack of a formal definition has led research to evolve into multiple and inconsistent paths. Furthermore, the existing ambiguity among researchers and practitioners undermines an efficient development of the subject. In this paper we have reviewed the existing literature on Big Data and analyzed its previous definitions in order to pursue two results: first, to provide a summary of the key research areas related to the phenomenon, identifying emerging trends and suggesting opportunities for future development; second, to provide a consensual definition for Big Data, by synthesizing common themes of existing works and patterns in previous definitions.

Quaternary prevention: reviewing the concept

PubMed Central

Martins, Carlos; Godycki-Cwirko, Maciek; Heleno, Bruno; Brodersen, John

2018-01-01

Abstract Background: According to the Wonca International Dictionary for General/Family Practice Quaternary Prevention is defined as: ‘Action taken to identify patient at risk of overmedicalization, to protect him from new medical invasion, and to suggest to him interventions, which are ethically acceptable.’ The concept of quaternary prevention was initially proposed by Marc Jamoulle and the targets were mainly patients with illness but without a disease. Objectives: The purpose of this opinion article is to open the debate around a new possible definition and a new conceptual model of quaternary prevention based on the belief that quaternary prevention should be present in physicians’ minds for every intervention they suggest to a patient. Discussion: The debate around quaternary prevention is vital in the context of contemporary medicine and has expanded worldwide. The human being may suffer harm from medical interventions from conception, during their childhood, during their entire healthy lifetime as well as during a self-limited disease, a chronic disease, or a terminal disease. The current definition of quaternary prevention has limitations because it excludes patients and medical interventions where a quaternary prevention perspective would be needed and useful to protect patients from harm. In this context, a new definition and conceptual model of quaternary prevention is proposed. Conclusion: In this new proposal, quaternary prevention is defined as an ‘action taken to protect individuals (persons/patients) from medical interventions that are likely to cause more harm than good.’ PMID:29384397

33 CFR 155.110 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Definitions. 155.110 Section 155.110 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) POLLUTION OIL OR HAZARDOUS MATERIAL POLLUTION PREVENTION REGULATIONS FOR VESSELS General § 155.110 Definitions...

33 CFR 155.110 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 33 Navigation and Navigable Waters 2 2011-07-01 2011-07-01 false Definitions. 155.110 Section 155.110 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) POLLUTION OIL OR HAZARDOUS MATERIAL POLLUTION PREVENTION REGULATIONS FOR VESSELS General § 155.110 Definitions...

33 CFR 155.110 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 33 Navigation and Navigable Waters 2 2014-07-01 2014-07-01 false Definitions. 155.110 Section 155.110 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) POLLUTION OIL OR HAZARDOUS MATERIAL POLLUTION PREVENTION REGULATIONS FOR VESSELS General § 155.110 Definitions...

33 CFR 155.110 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 33 Navigation and Navigable Waters 2 2013-07-01 2013-07-01 false Definitions. 155.110 Section 155.110 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) POLLUTION OIL OR HAZARDOUS MATERIAL POLLUTION PREVENTION REGULATIONS FOR VESSELS General § 155.110 Definitions...

33 CFR 155.110 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 33 Navigation and Navigable Waters 2 2012-07-01 2012-07-01 false Definitions. 155.110 Section 155.110 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) POLLUTION OIL OR HAZARDOUS MATERIAL POLLUTION PREVENTION REGULATIONS FOR VESSELS General § 155.110 Definitions...

Spontaneous adverse event signaling methods: classification and use with health care treatment products.

PubMed

Clark, J A; Klincewicz, S L; Stang, P E

2001-01-01

AE signal detection and its techniques are part of the continuum of public health surveillance, borrowing from both its theory and application (171). Like public health surveillance networks, whose major goals are to identify early signs of new outbreaks, pinpoint new organisms, and monitor designated illnesses, AE signaling and surveillance systems attempt to provide early warnings of previously unsuspected product-AE pairs, hypothesize potential drug-event relations, identify populations "at risk," and facilitate case ascertainment and definition. In both examples, definitive research is often subsequently undertaken to quantify the strength of relations that may be proposed. As with any public health surveillance effort, AE surveillance provides an infrastructure for the ongoing collection of health data and its direct integration into the health regulatory policy (172), including its keystone role in risk assessment and management. However, unlike many surveillance systems, postmarketing AE systems collect case information that is often relatively incomplete and imperfect, estimate exposure based on surrogate values (e.g., sales data), and are used by both governmental and the private sector for preventive planning. These factors make AE signaling and surveillance more ambiguous, regulatory oriented, and complex than its disease counterparts (173). Despite such issues, AE signaling methods continue to evolve in extent, complexity, and acceptance (4, 131, 174). Undoubtedly, this is largely due to the widespread practical experience that has been gained with spontaneous reporting systems over the past 4 decades and the cumulative usefulness that has been demonstrated.

Preventive Maintenance Process

NASA Technical Reports Server (NTRS)

Ciaruffoli, Veronica; Bramley, Craig; Matteson, Mike

2001-01-01

The Preventive Maintenance (PM) program at Stennis Space Center (SSC) evolved from an ineffective and poorly organized state to a highly organized state in which it became capable of tracking equipment, planning jobs with man hour estimates, and supporting outsourcing. This viewgraph presentation traces the steps the program took to improve itself.

33 CFR 155.1020 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-07-01

... the outer boundary of the nearshore area. Oil field waste means non-pumpable drilling fluids with... OIL OR HAZARDOUS MATERIAL POLLUTION PREVENTION REGULATIONS FOR VESSELS Tank Vessel Response Plans for Oil § 155.1020 Definitions. Except as otherwise defined in this section, the definitions in § 155.110...

28 CFR 905.1 - Definition.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 28 Judicial Administration 2 2012-07-01 2012-07-01 false Definition. 905.1 Section 905.1 Judicial Administration NATIONAL CRIME PREVENTION AND PRIVACY COMPACT COUNCIL NATIONAL FINGERPRINT FILE (NFF) PROGRAM QUALIFICATION REQUIREMENTS § 905.1 Definition. “National Fingerprint File” means a database of fingerprints, or...

28 CFR 905.1 - Definition.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 28 Judicial Administration 2 2011-07-01 2011-07-01 false Definition. 905.1 Section 905.1 Judicial Administration NATIONAL CRIME PREVENTION AND PRIVACY COMPACT COUNCIL NATIONAL FINGERPRINT FILE (NFF) PROGRAM QUALIFICATION REQUIREMENTS § 905.1 Definition. “National Fingerprint File” means a database of fingerprints, or...

28 CFR 905.1 - Definition.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Definition. 905.1 Section 905.1 Judicial Administration NATIONAL CRIME PREVENTION AND PRIVACY COMPACT COUNCIL NATIONAL FINGERPRINT FILE (NFF) PROGRAM QUALIFICATION REQUIREMENTS § 905.1 Definition. “National Fingerprint File” means a database of fingerprints, or...

28 CFR 905.1 - Definition.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 28 Judicial Administration 2 2013-07-01 2013-07-01 false Definition. 905.1 Section 905.1 Judicial Administration NATIONAL CRIME PREVENTION AND PRIVACY COMPACT COUNCIL NATIONAL FINGERPRINT FILE (NFF) PROGRAM QUALIFICATION REQUIREMENTS § 905.1 Definition. “National Fingerprint File” means a database of fingerprints, or...

28 CFR 905.1 - Definition.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 28 Judicial Administration 2 2014-07-01 2014-07-01 false Definition. 905.1 Section 905.1 Judicial Administration NATIONAL CRIME PREVENTION AND PRIVACY COMPACT COUNCIL NATIONAL FINGERPRINT FILE (NFF) PROGRAM QUALIFICATION REQUIREMENTS § 905.1 Definition. “National Fingerprint File” means a database of fingerprints, or...

A critical question for NEC researchers: Can we create a consensus definition of NEC that facilitates research progress?

PubMed

Gordon, Phillip V; Swanson, Jonathan R; MacQueen, Brianna C; Christensen, Robert D

2017-02-01

In the last decades the reported incidence of preterm necrotizing enterocolitis (NEC) has been declining in large part due to implementing comprehensive NEC prevention initiatives, including breast milk feeding, standardized feeding protocols, transfusion guidelines, and antibiotic stewardship and improving the rigor with which non-NEC cases are excluded from NEC data. However, after more than 60 years of NEC research in animal models, the promise of a "magic bullet" to prevent NEC has yet to materialize. There are also serious issues involving clinical NEC research. There is a lack of a common, comprehensive definition of NEC. National datasets have their own unique definition and staging definitions. Even within academia, randomized trials and single center studies have widely disparate definitions. This makes NEC metadata of very limited value. The world of neonatology needs a comprehensive, universal, consensus definition of NEC. It also needs a de-identified, international data warehouse. Copyright © 2016 Elsevier Inc. All rights reserved.

Simultaneous hermaphrodites reproducing in pairs self-fertilize some of their eggs: an experimental test of predictions of mixed-mating and Hermaphrodite's Dilemma theory.

PubMed

Lüscher, A; Milinski, M

2003-09-01

Theory predicts (1) that mixed-mating systems (i.e. reproduction through both selfing and outcrossing) should usually not evolve and (2) that reproducing simultaneous hermaphrodites should be in a conflict over the preferred sexual role (The Hermaphrodite's Dilemma). In an in vitro system with the endoparasitic cestode Schistocephalus solidus, a simultaneous hermaphrodite, we tested predictions of both the mixed-mating and the Hermaphrodite's Dilemma theory. Using microsatellite markers, we measured the proportion of selfed offspring and the total reproductive output of each worm within pairs varying in mean weight and weight difference. Worms produced more outbred offspring not only with increasing total weight of the pair, but also with decreasing weight difference between the two paired worms. These results suggest: (1) that this parasite species reproduces by mixed-mating, which may be maintained by stochastic density fluctuations in the definitive host and hence unpredictability of self reproduction and (2) reproductive conflict may prevent worm pairs from achieving an optimal intermediate selfing rate.

Assuring optimal trauma care: the role of trauma centre accreditation

PubMed Central

Simons, Richard; Kirkpatrick, Andrew

2002-01-01

Optimal care of the injured patient requires the delivery of appropriate, definitive care shortly after injury. Over the last 30 to 40 years, civilian trauma systems and trauma centres have been developed in the United States based on experience gained in military conflicts, particularly in Korea and Vietnam. A similar process is evolving in Canada. National trauma committees in the US and Canada have defined optimal resources to meet the goal of rapid, appropriate care in trauma centres. They have introduced programs (verification or accreditation) to externally audit trauma centre performance based on these guidelines. It is generally accepted that implementing trauma systems results in decreased preventable death and improved survival after trauma. What is less clear is the degree to which each facet of trauma system development contributes to this improvement. The relative importance of national performance guidelines and trauma centre audit as integral steps toward improved outcomes following injury are reviewed. Current Trauma Association of Canada guidelines for trauma centres are presented and the process of trauma centre accreditation is discussed. PMID:12174987

The biomechanics of upper extremity kinematic and kinetic modeling: applications to rehabilitation engineering.

PubMed

Slavens, Brooke A; Harris, Gerald F

2008-01-01

Human motion analysis has evolved from the lower extremity to the upper extremity. Rehabilitation engineering is reliant upon three-dimensional biome-chanical models for a thorough understanding of upper body motions and forces in order to improve treatment methods, rehabilitation strategies and to prevent injury. Due to the complex nature of upper body movements, a standard biomechanical model does not exist. This paper reviews several kinematic and kinetic rehabilitation engineering models from the literature. These models may capture a single joint; multijoints such as the shoulder, elbow and wrist; or a combination of joints and an ambulatory aid, which serves as the extension of the upper arm. With advances in software and hardware, new models continuously arise due to the clinical questions at hand. When designing a biomechanical upper extremity model, several key components must be determined. These include deciding on the anatomic segments of the model, the number of markers and placement on bony landmarks, the definition of joint coordinate systems, and the description of the joint motions. It is critical to apply the proper model to further our understanding of pathologic populations.

Bringing central line-associated bloodstream infection prevention home: CLABSI definitions and prevention policies in home health care agencies.

PubMed

Rinke, Michael L; Bundy, David G; Milstone, Aaron M; Deuber, Kristin; Chen, Allen R; Colantuoni, Elizabeth; Miller, Marlene R

2013-08-01

A study was conducted to investigate health care agency central line-associated bloodstream infection (CLABSI) definitions and prevention policies and pare them to the Joint Commission National Patient Safety Goal (NPSG.07.04.01), the Centers for Disease Control and Prevention (CDC) CLABSI prevention recommendations, and a best-practice central line care bundle for inpatients. A telephone-based survey was conducted in 2011 of a convenience sample of home health care agencies associated with children's hematology/oncology centers. Of the 97 eligible home health care agencies, 57 (59%) completed the survey. No agency reported using all five aspects of the National Healthcare and Safety Network/Association for Professionals in Infection Control and Epidemiology CLABSI definition and adjudication process, and of the 50 agencies that reported tracking CLABSI rates, 20 (40%) reported using none. Only 10 agencies (18%) had policies consistent with all elements of the inpatient-focused NPSG.07.04.01, 10 agencies (18%) were consistent with all elements of the home care targeted CDC CLABSI prevention recommendations, and no agencies were consistent with all elements of the central line care bundle. Only 14 agencies (25%) knew their overall CLABSI rate: mean 0.40 CLABSIs per 1,000 central line days (95% confidence interval [CI], 0.18 to 0.61). Six agencies (11%) knew their agency's pediatric CLABSI rate: mean 0.54 CLABSIs per 1,000 central line days (95% CI, 0.06 to 1.01). The policies of a national sample of home health care agencies varied significantly from national inpatient and home health care agency targeted standards for CLABSI definitions and prevention. Future research should assess strategies for standardizing home health care practices consistent with evidence-based recommendations.

Pediatric primary care as a component of systems of care.

PubMed

Brown, Jonathan D

2010-02-01

Systems of care should be defined in a manner that includes primary care. The current definition of systems of care shares several attributes with the definition of primary care: both are defined as community-based services that are accessible, accountable, comprehensive, coordinated, culturally competent, and family focused. However, systems of care is defined as serving only children and youth with serious emotional disturbance and their families and does not fully embrace the concept of primary prevention. Although similarities in the definitions of primary care and systems of care may provide a theoretical foundation for including primary care within the systems of care framework, a definition of systems of care that incorporates the idea of prevention and takes into account the broad population served in primary care would provide communities with a definition that can be used to further the work of integrating primary care into systems of care.

Evolving paradigm of illnesses presented to medical Intensive Care Unit in body builders: Cases from tertiary care center.

PubMed

Garg, Sunil Kumar

2015-04-01

Bodybuilding is the use of progressive resistance exercise to control and develop one's musculature. With the rise in number of persons adopting this activity, there is evolving paradigm of illnesses presented to intensive care in this population subset. Strict adherence to details of bodybuilding and avoidance of unsupervised medications are essential to prevent untoward effects.

Evolving paradigm of illnesses presented to medical Intensive Care Unit in body builders: Cases from tertiary care center

PubMed Central

Garg, Sunil Kumar

2015-01-01

Bodybuilding is the use of progressive resistance exercise to control and develop one's musculature. With the rise in number of persons adopting this activity, there is evolving paradigm of illnesses presented to intensive care in this population subset. Strict adherence to details of bodybuilding and avoidance of unsupervised medications are essential to prevent untoward effects. PMID:25878431

What's a Guy To Do?: Contraceptive Responsibility, Confronting Masculinity, and the History of Vasectomy in Canada.

PubMed

Shropshire, Sarah

2014-01-01

Despite the growing popularity of vasectomy in recent years, historians have largely ignored the history of the procedure. The current article provides a preliminary examination of voluntary male sterilization in Canada and, in so doing, challenges the gendered paradigm scholars have often applied to the history of contraception. State-sponsored Medicare and late decriminalization of contraception are discussed as factors that slowed widespread adoption of vasectomy in Canada while evolving surgical techniques are highlighted for their role in increasing acceptability of the procedure. The article explores how evolving definitions of hegemonic masculinity have both hindered and encouraged acceptance of vasectomy over time.

Geosynchronous platform definition study. Volume 6: Geosynchronous program evaluation and recommendations

NASA Technical Reports Server (NTRS)

Myers, H. L.

1973-01-01

The programmatic analyses conducted to achieve the objectives of the study are presented. The characteristics are examined of alternate geosynchronous programs based on servicing concepts, geosynchronous platform configurations, and equipment definitions which have evolved during the study. The logistics support necessary to carry out programs using these systems is defined considering alternate approaches for on-orbit servicing. The costs of the resultant programs are then determined and the alternate program approaches compared. Conventional programs with expendable satellites are also defined to the extent necessary to permit comparison with on-orbit serviced platform programs.

Consensus statement with recommendations on active surveillance inclusion criteria and definition of progression in men with localized prostate cancer: the critical role of the pathologist.

PubMed

Montironi, Rodolfo; Hammond, Elizabeth H; Lin, Daniel W; Gore, John L; Srigley, John R; Samaratunga, Hema; Egevad, Lars; Rubin, Mark A; Nacey, John; Klotz, Laurence; Sandler, Howard; Zietman, Anthony L; Holden, Stuart; Humphrey, Peter A; Evans, Andrew J; Delahunt, Brett; McKenney, Jesse K; Berney, Daniel; Wheeler, Thomas M; Chinnaiyan, Arul; True, Lawrence; Knudsen, Beatrice; Epstein, Jonathan I; Amin, Mahul B

2014-12-01

Active surveillance (AS) is an important management option for men with low-risk, clinically localized prostate cancer. The clinical parameters for patient selection and definition of progression for AS protocols are evolving as data from several large cohorts matures. Vital to this process is the critical role pathologic parameters play in identifying appropriate candidates for AS. These findings need to be reproducible and consistently reported by surgical pathologists. This report highlights the importance of accurate pathology reporting as a critical component of these protocols.

Child Neglect: State of Knowledge. Final Report.

ERIC Educational Resources Information Center

Polansky, Norman A.; And Others

The discussion of child neglect considers the following topics: definition, prevalence, etiology, identification and case finding, sequelae, prevention, and treatment. The differences between child neglect and child abuse and between the legal and professional definitions of child neglect are pointed out, and an operational definition is provided.…

Population genetics of chronic kidney disease: the evolving story of APOL1.

PubMed

Wasser, Walter G; Tzur, Shay; Wolday, Dawit; Adu, Dwomoa; Baumstein, Donald; Rosset, Saharon; Skorecki, Karl

2012-01-01

Advances in human genome sequencing and generation of public databases of genomic diversity enable nephrologists to re-examine the genetics of common, complex kidney diseases. Non-diabetic kidney diseases prevalent in African ancestry populations and the allelic variation described in chromosome 22q12.3 is one such illustrative example. Newly available genomic database information enabled research groups to discover common functional DNA sequence risk variants in the APOL1 gene. These variants (termed G1 and G2) evolved to confer protection from a species of trypanosomal infection and thus achieved high prominence in many geographic regions of Africa and have been carried over to African diaspora communities worldwide. Since these discoveries two years ago, new insights have been gained: localization of APOL1 in normal and disease kidney tissues; influence of the APOL1 variants on the histopathology of HIV kidney disease; possible association with kidney transplant durability; onset of kidney failure at a younger age; association with blood lipid concentrations; more precise geographic localization of individuals with these variants to western and southern African ancestry; and the absence of the variants and kidney disease predisposition in Ethiopians. The definition of APOL1 nephropathy also confirms the long-held assumption by many clinicians that kidney disease attributed to hypertension in African populations represents an underlying glomerulopathy. Still awaited is the delineation of the biologic mechanisms of cellular injury related to these variants, to provide biologic proof of the APOL1 association and to provide potential targets for preventive and therapeutic intervention.

Social Network Analysis of 50 Years of International Collaboration in the Research of Educational Technology

ERIC Educational Resources Information Center

Guo, Shesen; Zhang, Ganzhou; Guo, Yufei

2016-01-01

The definition of the field of educational technology has evolved over 50 years. New inventions and economic globalization increasingly facilitate people's communication for exchange of ideas and collaboration. This work attempts to describe international research collaboration in educational technology for the past 50 years. This article intends…

Genius Loci: MacConnell Award Projects + Ewan McIntosh's Seven Spaces

ERIC Educational Resources Information Center

Baibak, Rebecca; Ruiz, Karina; Parker, Ross; Peters, Edward J.

2011-01-01

The surge of technology use in the 21st century is providing an opportunity for school facilities to reevaluate the value and definition of educational place. Traditionally, schools have served as places for information finding, project creating, publishing and presenting student work. They have evolved into places to support technological tools…

Comments on Where the Creativity Research Has Been and Where Is It Going

ERIC Educational Resources Information Center

Runco, Mark A.

2017-01-01

This Commentary examines where the creativity research has been and where it is going. They key points include evolving definitions of creativity, interdisciplinarity in the creativity research, divergent thinking as a reliable index of creative potential, improvements in testing, the impact of technology, the inclusion of political, moral, and…

Institutional v. Technical Environments: Reconciling the Goals of Decentralization in an Evolving Charter School Organization

ERIC Educational Resources Information Center

Huerta, Luis A.

2009-01-01

This article analyzes how macrolevel institutional forces persist and limit the expansion of decentralized schools that attempt to challenge normative definitions and practices of traditional school organizations. Using qualitative case study methodology, the analysis focuses on how one decentralized charter school navigated and reconciled its…

Bergsonian Comedy and the Human Machines in "Star Wars."

ERIC Educational Resources Information Center

Roth, Lane

While analyzing humor is difficult, Henri Bergson's concept of comedy (a person acting like a machine) outlined in the classic essay, "Le Rire," in 1900, is probably too narrow a definition. Science fiction film, a genre which has evolved since the publication of Bergson's essay, has also speculated about man and society, often to…

Toward a Process-Focused Model of Test Score Validity: Improving Psychological Assessment in Science and Practice

ERIC Educational Resources Information Center

Bornstein, Robert F.

2011-01-01

Although definitions of validity have evolved considerably since L. J. Cronbach and P. E. Meehl's classic (1955) review, contemporary validity research continues to emphasize correlational analyses assessing predictor-criterion relationships, with most outcome criteria being self-reports. The present article describes an alternative way of…

Principles for Designing Pragmatic Knowledge Management Systems

ERIC Educational Resources Information Center

Cavaleri, Steven A.

2004-01-01

Knowledge management continues to evolve as a discipline, yet even basic features that define a discipline have to be established. Developing a shared understanding of core concepts, such as the meaning of "knowledge", has been elusive in this field. In the absence of reaching a universal definition, surrogates for knowledge are adopted because of…

Practicality in Curriculum Building: A Historical Perspective on the Mission of Chinese Education

ERIC Educational Resources Information Center

Bai, Limin

2013-01-01

This paper examines how the definition and interpretation of the concept gewu zhizhi ???? (investigating things and extending knowledge), evolved along with Chinese intellectual efforts to construct the framework for Chinese learning which, in turn, had a profound impact on the development of educational curricula in different historical periods.…

Historical and Theoretical Development of Culturally Competent Social Work Practice

ERIC Educational Resources Information Center

Kohli, Hermeet K.; Huber, Ruth; Faul, Anna C.

2010-01-01

This article provides a detailed review of the historical and theoretical context in which culturally competent practice has evolved in the social work profession and enables educators and practitioners to see holistic connections between the past and present. Historical review of the inclusion of diversity content is followed by definitions of…

Established and Evolving Spoken Research Process Genres: Plenary Lecture and Poster Session Discussions at Academic Conferences.

ERIC Educational Resources Information Center

Shalom, Celia

1993-01-01

Two types of main hall discussions at an ecology conference were studied: plenary lecture discussion as an accepted, established spoken research process genre with its own conventions; and poster session discussion as a fragile, embryonic research process genre struggling for definition. (14 references) (Author/LB)

Evolving issues in the management of reflux disease?

PubMed

Yuan, Yuhong; Hunt, Richard H

2009-07-01

Gastroesophageal reflux disease (GERD) is a common chronic disorder often successfully treated, although there are several evolving issues in management. We reviewed the issues related to unmet needs over the past 12 months. A substantial number of patients fail to respond adequately to once or even twice daily proton pump inhibitor (PPI). There is no standard definition of PPI failure in GERD; a universally accepted definition for treatment success is also not available. Differentiation between erosive esophagitis and nonerosive reflux disease can be made but requires endoscopy; but studies still confuse functional heartburn and nonerosive reflux disease, which impacts management. Acid reflux plays an important role in GERD pathogenesis and the precise role of acid requires more studies of differences between erosive esophagitis and nonerosive reflux disease symptom generation and the implication of nocturnal acidification. Several possible mechanisms may explain GERD refractory to PPIs. Management of PPI nonresponders remains a challenge. Objective and precise evaluation of symptoms and treatment response requires study in high-quality trials. New therapeutic approaches are under investigation to answer unmet needs and improve erosive esophagitis healing rates and symptom control.

Can we measure memes?

PubMed

McNamara, Adam

2011-01-01

Memes are the fundamental unit of cultural evolution and have been left upon the periphery of cognitive neuroscience due to their inexact definition and the consequent presumption that they are impossible to measure. Here it is argued that although a precise definition of memes is rather difficult it does not preclude highly controlled experiments studying the neural substrates of their initiation and replication. In this paper, memes are termed as either internally or externally represented (i-memes/e-memes) in relation to whether they are represented as a neural substrate within the central nervous system or in some other form within our environment. It is argued that neuroimaging technology is now sufficiently advanced to image the connectivity profiles of i-memes and critically, to measure changes to i-memes over time, i.e., as they evolve. It is argued that it is wrong to simply pass off memes as an alternative term for "stimulus" and "learnt associations" as it does not accurately account for the way in which natural stimuli may dynamically "evolve" as clearly observed in our cultural lives.

Prevention of Food Poisoning.

ERIC Educational Resources Information Center

Army Quartermaster School, Ft. Lee, VA.

The programed text provides a single lesson, four-hour, correspondence subcourse on the prevention of food poisoning. It covers the following areas: a definition of food poisoning; chemical food poisoning; biological food poisoning; causes and prevention of trichinosis; six factors controlling bacteria growth; bacterial infection; prevention of…

Quantitative conditions for time evolution in terms of the von Neumann equation

NASA Astrophysics Data System (ADS)

Wang, WenHua; Cao, HuaiXin; Chen, ZhengLi; Wang, Lie

2018-07-01

The adiabatic theorem describes the time evolution of the pure state and gives an adiabatic approximate solution to the Schödinger equation by choosing a single eigenstate of the Hamiltonian as the initial state. In quantum systems, states are divided into pure states (unite vectors) and mixed states (density matrices, i.e., positive operators with trace one). Accordingly, mixed states have their own corresponding time evolution, which is described by the von Neumann equation. In this paper, we discuss the quantitative conditions for the time evolution of mixed states in terms of the von Neumann equation. First, we introduce the definitions for uniformly slowly evolving and δ-uniformly slowly evolving with respect to mixed states, then we present a necessary and sufficient condition for the Hamiltonian of the system to be uniformly slowly evolving and we obtain some upper bounds for the adiabatic approximate error. Lastly, we illustrate our results in an example.

Volatile, isotope, and organic analysis of martian fines with the Mars Curiosity rover.

PubMed

Leshin, L A; Mahaffy, P R; Webster, C R; Cabane, M; Coll, P; Conrad, P G; Archer, P D; Atreya, S K; Brunner, A E; Buch, A; Eigenbrode, J L; Flesch, G J; Franz, H B; Freissinet, C; Glavin, D P; McAdam, A C; Miller, K E; Ming, D W; Morris, R V; Navarro-González, R; Niles, P B; Owen, T; Pepin, R O; Squyres, S; Steele, A; Stern, J C; Summons, R E; Sumner, D Y; Sutter, B; Szopa, C; Teinturier, S; Trainer, M G; Wray, J J; Grotzinger, J P

2013-09-27

Samples from the Rocknest aeolian deposit were heated to ~835°C under helium flow and evolved gases analyzed by Curiosity's Sample Analysis at Mars instrument suite. H2O, SO2, CO2, and O2 were the major gases released. Water abundance (1.5 to 3 weight percent) and release temperature suggest that H2O is bound within an amorphous component of the sample. Decomposition of fine-grained Fe or Mg carbonate is the likely source of much of the evolved CO2. Evolved O2 is coincident with the release of Cl, suggesting that oxygen is produced from thermal decomposition of an oxychloride compound. Elevated δD values are consistent with recent atmospheric exchange. Carbon isotopes indicate multiple carbon sources in the fines. Several simple organic compounds were detected, but they are not definitively martian in origin.

49 CFR 541.4 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-10-01

..., DEPARTMENT OF TRANSPORTATION FEDERAL MOTOR VEHICLE THEFT PREVENTION STANDARD § 541.4 Definitions. (a... same make. (4) 1990/91 median theft rate means 3.5826 thefts per thousand vehicles produced. (5...

Child maltreatment in DSM-5 and ICD-11.

PubMed

Slep, Amy M Smith; Heyman, Richard E; Foran, Heather M

2015-03-01

Child maltreatment is widespread and has a tremendous impact on child victims and their families. Over the past decade, definitions of child maltreatment have been developed that are operationalized, face valid, and can be reliably applied in clinical settings. These definitions have informed the revised Diagnostic and Statistical Manual (American Psychiatric Association, 2013) and are being considered for the International Classification of Disease-11 (World Health Organization). Now that these definitions are available in major diagnostic systems, primary healthcare providers and clinicians who see children and families are poised to help screen for, identify, prevent, and treat child maltreatment. This article reviews the definitions of maltreatment in these diagnostic systems, along with assessment and screening tools, and empirically supported prevention and intervention approaches. © 2015 Family Process Institute.

Enhancing clinical decision making: development of a contiguous definition and conceptual framework.

PubMed

Tiffen, Jennifer; Corbridge, Susan J; Slimmer, Lynda

2014-01-01

Clinical decision making is a term frequently used to describe the fundamental role of the nurse practitioner; however, other terms have been used interchangeably. The purpose of this article is to begin the process of developing a definition and framework of clinical decision making. The developed definition was "Clinical decision making is a contextual, continuous, and evolving process, where data are gathered, interpreted, and evaluated in order to select an evidence-based choice of action." A contiguous framework for clinical decision making specific for nurse practitioners is also proposed. Having a clear and unique understanding of clinical decision making will allow for consistent use of the term, which is relevant given the changing educational requirements for nurse practitioners and broadening scope of practice. Copyright © 2014 Elsevier Inc. All rights reserved.

Definitions of School Bullying in Taiwan: A Comparison of Multiple Perspectives

ERIC Educational Resources Information Center

Cheng, Ying-Yao; Chen, Li-Ming; Ho, Hsiao-Chi; Cheng, Chih-Ling

2011-01-01

Investigating teachers' and students' different definitions of school bullying is important for necessary prevention and effective intervention. This study compared definitions of bullying from the perspectives of bystanders, bullies, victims, and educators. A total of 1,558 secondary educators and students in Taiwan participated in this research,…

49 CFR 130.5 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 49 Transportation 2 2013-10-01 2013-10-01 false Definitions. 130.5 Section 130.5 Transportation..., DEPARTMENT OF TRANSPORTATION OIL TRANSPORTATION OIL SPILL PREVENTION AND RESPONSE PLANS § 130.5 Definitions... flow of over two inches (50 mm) within a three-minute period, or a material having one gram or more...

49 CFR 130.5 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 49 Transportation 2 2012-10-01 2012-10-01 false Definitions. 130.5 Section 130.5 Transportation..., DEPARTMENT OF TRANSPORTATION OIL TRANSPORTATION OIL SPILL PREVENTION AND RESPONSE PLANS § 130.5 Definitions... flow of over two inches (50 mm) within a three-minute period, or a material having one gram or more...

49 CFR 130.5 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 49 Transportation 2 2014-10-01 2014-10-01 false Definitions. 130.5 Section 130.5 Transportation..., DEPARTMENT OF TRANSPORTATION OIL TRANSPORTATION OIL SPILL PREVENTION AND RESPONSE PLANS § 130.5 Definitions... flow of over two inches (50 mm) within a three-minute period, or a material having one gram or more...

32 CFR 85.3 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-07-01

..., health promotion includes smoking prevention and cessation, physical fitness, nutrition, stress management, alcohol and drug abuse prevention, and early identification of hypertension. Lifestyle. The...

32 CFR 85.3 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-07-01

..., health promotion includes smoking prevention and cessation, physical fitness, nutrition, stress management, alcohol and drug abuse prevention, and early identification of hypertension. Lifestyle. The...

32 CFR 85.3 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-07-01

..., health promotion includes smoking prevention and cessation, physical fitness, nutrition, stress management, alcohol and drug abuse prevention, and early identification of hypertension. Lifestyle. The...

32 CFR 85.3 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-07-01

..., health promotion includes smoking prevention and cessation, physical fitness, nutrition, stress management, alcohol and drug abuse prevention, and early identification of hypertension. Lifestyle. The...

32 CFR 85.3 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-07-01

..., health promotion includes smoking prevention and cessation, physical fitness, nutrition, stress management, alcohol and drug abuse prevention, and early identification of hypertension. Lifestyle. The...

7 CFR 2902.44 - Corrosion preventatives.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 15 2010-01-01 2010-01-01 false Corrosion preventatives. 2902.44 Section 2902.44... Items § 2902.44 Corrosion preventatives. (a) Definition. Products designed to prevent the deterioration (corrosion) of metals. (b) Minimum biobased content. The preferred procurement product must have a minimum...

7 CFR 2902.44 - Corrosion preventatives.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 7 Agriculture 15 2011-01-01 2011-01-01 false Corrosion preventatives. 2902.44 Section 2902.44... Items § 2902.44 Corrosion preventatives. (a) Definition. Products designed to prevent the deterioration (corrosion) of metals. (b) Minimum biobased content. The preferred procurement product must have a minimum...

7 CFR 3201.44 - Corrosion preventatives.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 7 Agriculture 15 2012-01-01 2012-01-01 false Corrosion preventatives. 3201.44 Section 3201.44... Designated Items § 3201.44 Corrosion preventatives. (a) Definition. Products designed to prevent the deterioration (corrosion) of metals. (b) Minimum biobased content. The preferred procurement product must have a...

7 CFR 3201.44 - Corrosion preventatives.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 7 Agriculture 15 2014-01-01 2014-01-01 false Corrosion preventatives. 3201.44 Section 3201.44... Designated Items § 3201.44 Corrosion preventatives. (a) Definition. Products designed to prevent the deterioration (corrosion) of metals. (b) Minimum biobased content. The preferred procurement product must have a...

7 CFR 3201.44 - Corrosion preventatives.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 7 Agriculture 15 2013-01-01 2013-01-01 false Corrosion preventatives. 3201.44 Section 3201.44... Designated Items § 3201.44 Corrosion preventatives. (a) Definition. Products designed to prevent the deterioration (corrosion) of metals. (b) Minimum biobased content. The preferred procurement product must have a...

From Germline Genetics to Somatic Insights – The Evolving Landscape of Hereditary Breast and Ovarian Cancer | Division of Cancer Prevention

Cancer.gov

Speaker | "From Germline Genetics to Somatic Insights – The Evolving Landscape of Hereditary Breast and Ovarian Cancer" will be presented by Katharine L. Nathanson, MD, Professor of Medicine at the University of Pennsylvania Perelman School of Medicine in Philadelphia, PA. Date: February 6, 2018; Time: 11:00am-12:00pm; Location: NCI Shady Grove Campus, Conference Room Seminar

The MSFC Collaborative Engineering Process for Preliminary Design and Concept Definition Studies

NASA Technical Reports Server (NTRS)

Mulqueen, Jack; Jones, David; Hopkins, Randy

2011-01-01

This paper describes a collaborative engineering process developed by the Marshall Space Flight Center's Advanced Concepts Office for performing rapid preliminary design and mission concept definition studies for potential future NASA missions. The process has been developed and demonstrated for a broad range of mission studies including human space exploration missions, space transportation system studies and in-space science missions. The paper will describe the design team structure and specialized analytical tools that have been developed to enable a unique rapid design process. The collaborative engineering process consists of integrated analysis approach for mission definition, vehicle definition and system engineering. The relevance of the collaborative process elements to the standard NASA NPR 7120.1 system engineering process will be demonstrated. The study definition process flow for each study discipline will be will be outlined beginning with the study planning process, followed by definition of ground rules and assumptions, definition of study trades, mission analysis and subsystem analyses leading to a standardized set of mission concept study products. The flexibility of the collaborative engineering design process to accommodate a wide range of study objectives from technology definition and requirements definition to preliminary design studies will be addressed. The paper will also describe the applicability of the collaborative engineering process to include an integrated systems analysis approach for evaluating the functional requirements of evolving system technologies and capabilities needed to meet the needs of future NASA programs.

Brazilian guidelines on prevention of cardiovascular disease in patients with diabetes: a position statement from the Brazilian Diabetes Society (SBD), the Brazilian Cardiology Society (SBC) and the Brazilian Endocrinology and Metabolism Society (SBEM).

PubMed

Bertoluci, Marcello Casaccia; Moreira, Rodrigo Oliveira; Faludi, André; Izar, Maria Cristina; Schaan, Beatriz D; Valerio, Cynthia Melissa; Bertolami, Marcelo Chiara; Chacra, Ana Paula; Malachias, Marcus Vinicius Bolivar; Vencio, Sérgio; Saraiva, José Francisco Kerr; Betti, Roberto; Turatti, Luiz; Fonseca, Francisco Antonio Helfenstein; Bianco, Henrique Tria; Sulzbach, Marta; Bertolami, Adriana; Salles, João Eduardo Nunes; Hohl, Alexandre; Trujilho, Fábio; Lima, Eduardo Gomes; Miname, Marcio Hiroshi; Zanella, Maria Teresa; Lamounier, Rodrigo; Sá, João Roberto; Amodeo, Celso; Pires, Antonio Carlos; Santos, Raul D

2017-01-01

Since the first position statement on diabetes and cardiovascular prevention published in 2014 by the Brazilian Diabetes Society, the current view on primary and secondary prevention in diabetes has evolved as a result of new approaches on cardiovascular risk stratification, new cholesterol lowering drugs, and new anti-hyperglycemic drugs. Importantly, a pattern of risk heterogeneity has emerged, showing that not all diabetic patients are at high or very high risk. In fact, most younger patients who have no overt cardiovascular risk factors may be more adequately classified as being at intermediate or even low cardiovascular risk. Thus, there is a need for cardiovascular risk stratification in patients with diabetes. The present panel reviews the best current evidence and proposes a practical risk-based approach on treatment for patients with diabetes. The Brazilian Diabetes Society, the Brazilian Society of Cardiology, and the Brazilian Endocrinology and Metabolism Society gathered to form an expert panel including 28 cardiologists and endocrinologists to review the best available evidence and to draft up-to-date an evidence-based guideline with practical recommendations for risk stratification and prevention of cardiovascular disease in diabetes. The guideline includes 59 recommendations covering: (1) the impact of new anti-hyperglycemic drugs and new lipid lowering drugs on cardiovascular risk; (2) a guide to statin use, including new definitions of LDL-cholesterol and in non-HDL-cholesterol targets; (3) evaluation of silent myocardial ischemia and subclinical atherosclerosis in patients with diabetes; (4) hypertension treatment; and (5) the use of antiplatelet therapy. Diabetes is a heterogeneous disease. Although cardiovascular risk is increased in most patients, those without risk factors or evidence of sub-clinical atherosclerosis are at a lower risk. Optimal management must rely on an approach that will cover both cardiovascular disease prevention in individuals in the highest risk as well as protection from overtreatment in those at lower risk. Thus, cardiovascular prevention strategies should be individualized according to cardiovascular risk while intensification of treatment should focus on those at higher risk.

It's Time to Redefine Moore's Law Again

DOE Office of Scientific and Technical Information (OSTI.GOV)

DeBenedictis, Erik P.

The familiar story of Moore's law is actually inaccurate. Here, this article corrects the story, leading to different projections for the future. Moore's law is a fluid idea whose definition changes over time. It thus doesn't have the ability to "end," as is popularly reported, but merely takes different forms as the semiconductor and computer industries evolve.

Sequential Research Needs in Evolving Disciplines of Social Practice.

ERIC Educational Resources Information Center

Knowles, Malcolm S.

The author suggests that the emerging fields of social practice (such as recreation, social work, and adult education) must all go through a sequential pattern of research needs, first superficially, and then in ever deeper cycles. The six phases of these research needs are: definition of the field (survey and descriptive studies, census studies,…

Life cycle impacts of manufacturing redwood decking in Northern California

Treesearch

Richard D. Bergman; Elaine Oneil; Ivan L. Eastin; Han-Sup Han

2014-01-01

Awareness of the environmental footprint of building construction and use has led to increasing interest in green building. Defining a green building is an evolving process with life cycle inventory and life cycle impact assessment (LCIA) emerging as key tools in that evolution and definition process. This study used LCIA to determine the environmental footprint...

Evolving a Public Language of Spirituality for Transforming Academic and Campus Life

ERIC Educational Resources Information Center

Gunnlaugson, Olen; Vokey, Daniel

2014-01-01

A growing interest in spirituality in higher education has been accompanied by a range of responses to the challenge of defining the term. These responses include avoiding the problem by leaving it undefined; stipulating a particular and often context-specific definition of spirituality; and practising a kind of ad hoc eclecticism. This article…

Teaching the English Language Arts with Technology: A Critical Approach and Pedagogical Framework

ERIC Educational Resources Information Center

Young, Carl A.; Bush, Jonathan

2004-01-01

In order to cultivate the kind of technology literacy in our students called for by leaders in the field, it must simultaneously be cultivated in our teachers. While the literature in the field of English education demonstrates the efficacy of computer technology in writing instruction and addresses its impact on the evolving definition of…

How Students Learn from Multiple Contexts and Definitions: Proper Time as a Coordination Class

ERIC Educational Resources Information Center

Levrini, Olivia; diSessa, Andrea A.

2008-01-01

This article provides an empirical analysis of a single classroom episode in which students reveal difficulties with the concept of proper time in special relativity but slowly make progress in improving their understanding. The theoretical framework used is "coordination class theory," which is an evolving model of concepts and conceptual change.…

Evolving Systems of Care with Total Clinical Outcomes Management

ERIC Educational Resources Information Center

Lyons, John S.; Epstein, Richard A.; Jordan, Neil

2010-01-01

The current article proposes that further specification of the system of care concept is required. Based on the assertions that the system of care concept (a) refers to an ideal as opposed to an observable phenomenon, and (b) is engaged in offering transformational experiences, the authors propose that the system of care definition must be…

Bullying and the Twice-Exceptional Student

ERIC Educational Resources Information Center

Franklin-Rohr, Cheryl

2012-01-01

Bullying has been an ongoing problem for students, but the issue is becoming more critical with changes in the society and the school systems. A bully is no longer "a person who hurts, frightens, threatens, or tyrannizes over those who are smaller or weaker". According to Tracy Cross, the definition of a bully now is evolving to include any person…

Young People Experiencing Behavioural Difficulties: Discourses through the Decades

ERIC Educational Resources Information Center

Macfarlane, Angus H.; Hendy, Vivien; Macfarlane, Sonja

2010-01-01

History has informed the present, as surely as the present will inform the future. As an evolving society, we are continually reflecting on the events and experiences of the past, taking stock of the issues and realities of the present, and then adapting the parameters, definitions and constructs that serve to define acceptability and reason as we…

Information Integration for Concurrent Engineering (IICE) IDEF3 Process Description Capture Method Report

DTIC Science & Technology

1992-05-01

methodology, knowledge acquisition, 140 requirements definition, information systems, information engineering, 16. PRICE CODE systems engineering...and knowledge resources. Like manpower, materials, and machines, information and knowledge assets are recognized as vital resources that can be...evolve towards an information -integrated enterprise. These technologies are designed to leverage information and knowledge resources as the key

It's Time to Redefine Moore's Law Again

DOE PAGES

DeBenedictis, Erik P.

2017-02-06

The familiar story of Moore's law is actually inaccurate. Here, this article corrects the story, leading to different projections for the future. Moore's law is a fluid idea whose definition changes over time. It thus doesn't have the ability to "end," as is popularly reported, but merely takes different forms as the semiconductor and computer industries evolve.

Making Sense of Women as Career Self-Agents: Implications for Human Resource Development

ERIC Educational Resources Information Center

Shapiro, Mary; Ingols, Cynthia; O'Neill, Regina; Blake-Beard, Stacy

2009-01-01

In this article, we explore the shifting career paradigm of managerial women in the United States, what it may indicate for the broader professional workforce, and human resource development's (HRD's) role in supporting that change. We examine the literature on evolving career definitions, women's place in that evolution, the rising use of…

Considerations for the definition, measurement, consequences, and prevention of dating violence victimization among adolescent girls.

PubMed

Teten, Andra L; Ball, Barbara; Valle, Linda Anne; Noonan, Rita; Rosenbluth, Barri

2009-07-01

Violence experienced by adolescent girls from their dating partners poses considerable threat to their health and well-being. This report provides an overview of the prevalence and consequences of heterosexual teen dating violence and highlights the need for comprehensive prevention approaches to dating violence. We also discuss some considerations and future directions for the study and prevention of dating violence. We begin with a discussion of the definition of dating violence and also discuss measurement concerns and the need for evaluation of prevention strategies. Although women and men of all ages may be the victims or perpetrators, male-to-female dating violence experienced by adolescent girls is the main focus of this article. We incorporate research regarding girls' perpetration of dating violence where appropriate and as it relates to prevention.

75 FR 73017 - Approval and Promulgation of Implementation Plans; Georgia: Prevention of Significant...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-29

... produce ethanol through a natural fermentation process from the definition of ``chemical process plants... facilities that produce ethanol through a natural fermentation process from the definition of ``chemical...

Redefining Health: The Evolution of Health Ideas from Antiquity to the Era of Value-Based Care.

PubMed

Badash, Ido; Kleinman, Nicole P; Barr, Stephanie; Jang, Julie; Rahman, Suraiya; Wu, Brian W

2017-02-09

The current healthcare system in the United States (US) is characterized by high costs and poor patient outcomes. A value-based healthcare system, centered on providing the highest quality of care for the lowest cost, is the country's chosen solution for its healthcare crisis. As the US transitions to a value-based model, a new definition of health is necessary to clearly define what constitutes a healthy state. However, such a definition is impossible to develop without a proper understanding of what "health" actually means. To truly understand its meaning, one must have a thorough historical understanding of the changes in the concept of health and how it has evolved to reflect the beliefs and scientific understanding of each time period. Thus, this review summarizes the changes in the definition of health over time in order to provide a context for the definition needed today. We then propose a new definition of health that is specifically tailored to providers working in the era of value-based care.

Redefining Health: The Evolution of Health Ideas from Antiquity to the Era of Value-Based Care

PubMed Central

Kleinman, Nicole P; Barr, Stephanie; Jang, Julie; Rahman, Suraiya; Wu, Brian W

2017-01-01

The current healthcare system in the United States (US) is characterized by high costs and poor patient outcomes. A value-based healthcare system, centered on providing the highest quality of care for the lowest cost, is the country’s chosen solution for its healthcare crisis. As the US transitions to a value-based model, a new definition of health is necessary to clearly define what constitutes a healthy state. However, such a definition is impossible to develop without a proper understanding of what “health” actually means. To truly understand its meaning, one must have a thorough historical understanding of the changes in the concept of health and how it has evolved to reflect the beliefs and scientific understanding of each time period. Thus, this review summarizes the changes in the definition of health over time in order to provide a context for the definition needed today. We then propose a new definition of health that is specifically tailored to providers working in the era of value-based care.  PMID:28348937

From problem solving to problem definition: scrutinizing the complex nature of clinical practice.

PubMed

Cristancho, Sayra; Lingard, Lorelei; Regehr, Glenn

2017-02-01

In medical education, we have tended to present problems as being singular, stable, and solvable. Problem solving has, therefore, drawn much of medical education researchers' attention. This focus has been important but it is limited in terms of preparing clinicians to deal with the complexity of the 21st century healthcare system in which they will provide team-based care for patients with complex medical illness. In this paper, we use the Soft Systems Engineering principles to introduce the idea that in complex, team-based situations, problems usually involve divergent views and evolve with multiple solution iterations. As such we need to shift the conversation from (1) problem solving to problem definition, and (2) from a problem definition derived exclusively at the level of the individual to a definition derived at the level of the situation in which the problem is manifested. Embracing such a focus on problem definition will enable us to advocate for novel educational practices that will equip trainees to effectively manage the problems they will encounter in complex, team-based healthcare.

The new sepsis definition: limitations and contribution to research and diagnosis of sepsis.

PubMed

Verdonk, Franck; Blet, Alice; Mebazaa, Alexandre

2017-04-01

Based on recent clinical, epidemiological, and pathophysiological data, a third international consensus conference was carried out to define new criteria of sepsis in February 2016. This review presents the different items of this new definition, their limitations and their contribution to research and diagnosis of sepsis, in comparison with the previous definitions. Incidence, management, and pathophysiological knowledge of sepsis have improved over the past 20 years. However, sepsis still evolves to a mortal outcome, in one case out of five, with no new recent or specific therapy showing its efficacy on the patient's prognosis. These findings have led to the development of new definition. The new definition of sepsis incorporates relevant clinical and biological criteria such as SOFA score or serum lactate levels. It no longer takes into account the items of the systemic inflammatory response syndrome, which present a lack of specificity. It also simplifies the different stages of severity by deleting the term of 'severe sepsis' and by defining septic shock as a subset of sepsis. This definition, endorsed by only two international societies of intensive care, has some limitations and so merits prospective validation at different levels.

Evolving the use of peptides as biomaterials components

PubMed Central

Collier, Joel H.; Segura, Tatiana

2012-01-01

This manuscript is part of a debate on the statement that “the use of short synthetic adhesion peptides, like RGD, is the best approach in the design of biomaterials that guide cell behavior for regenerative medicine and tissue engineering”. We take the position that although there are some acknowledged disadvantages of using short peptide ligands within biomaterials, it is not necessary to discard the notion of using peptides within biomaterials entirely, but rather to reinvent and evolve their use. Peptides possess advantageous chemical definition, access to non-native chemistries, amenability to de novo design, and applicability within parallel approaches. Biomaterials development programs that require such aspects may benefit from a peptide-based strategy. PMID:21515167

Missed opportunities?: an evaluation of potentially preventable poisoning deaths.

PubMed

Srisuma, Sahaphume; Cao, Dazhe; Kleinschmidt, Kurt; Heffner, Alan C; Lavonas, Eric J

2016-06-01

Although most poisoning deaths are not preventable with current medical technology, in some cases different management decisions may have prevented fatal outcomes. This study aims to review reported poisoning-related deaths for preventability to provide insight to improve future care. Fatality abstracts published in the US National Poison Data System (NPDS) Annual Reports (2008-2012) were analyzed. Preventability was graded using a Likert scale of 1 (definitely non-preventable) to 6 (definitely preventable). Two medical toxicologists screened all cases. Cases deemed definitely not preventable (score 1) by both reviewers were excluded from further review and considered to be "non-preventable". All cases considered at least possibly preventable by either screener were reviewed by a multidisciplinary panel of 5 physicians for preventability scoring. Differences were resolved by consensus. Cases determined to be "preventable" (scores 4-6) were characterized by type of improvement issue involved (diagnosis, treatment, monitoring, other) and recurring scenarios. Of 390 published abstracts, 78 (20.0%) deaths were considered at least possibly preventable by at least one screener. Of these, 34 (8.7%) deaths were determined to be "preventable" by the panel. Inter-observer agreement by weighted kappa analysis was 0.58 for screening, 0.24 for preventability, and 0.44 for specific aspects of care. The most common toxicants were salicylates (n = 9), opioids (n = 4), toxic alcohols (n = 3), fluoride containing product (n = 3), and bupropion (n = 3). The most common improvement opportunities involved treatment and monitoring. Most of the ingested substances in preventable deaths have delayed GI absorption or require metabolic activation to produce a delayed effect (such as salicylates, opioids, and toxic alcohols), and therefore provide an opportunity for early recognition and successful interventions. Most improvement opportunities are clearly described in the literature but may be not recognized. Based on an analysis of published NPDS data, a considerable number of poisoning-related deaths reaching medical attention may be preventable. The most common scenarios involved in potentially preventable poisoning fatalities related to monitoring and treatment. Salicylates and opioids were the most common agents involved in preventable deaths.

Power system requirements and definition for lunar and Mars outposts

NASA Technical Reports Server (NTRS)

Petri, D. A.; Cataldo, R. L.; Bozek, J. M.

1990-01-01

Candidate power systems being considered for outpost facilities (stationary power systems) and vehicles (mobile systems) are discussed, including solar, chemical, isotopic, and reactor. The current power strategy was an initial outpost power system composed of photovoltaic arrays for daytime energy needs and regenerative fuel cells for power during the long lunar night. As day and night power demands grow, the outpost transitions to nuclear-based power generation, using thermoelectric conversion initially and evolving to a dynamic conversion system. With this concept as a guideline, a set of requirements has been established, and a reference definition of candidate power systems meeting these requirements has been identified.

Geosynchronous platform definition study. Volume 5: Geosynchronous platform synthesis

NASA Technical Reports Server (NTRS)

1973-01-01

The development is described of the platform configurations, support subsystems, mission equipment, and servicing concepts. A common support module is developed; subsystem concepts are traded off; data relay, TDRS, earth observational, astro-physics, and advanced navigation and traffic control mission equipment concepts are postulated; and ancillary equipment required for delivery and on-orbit servicing interfaces with geosynchronous platforms is grossly defined. The general approach was to develop a platform concept capable of evolving through three on-orbit servicing modes: remote, EVA, and shirtsleeve. The definition of the equipment is to the assembly level. Weight, power, and volumetric data are compiled for all the platforms.

Definition of technology development missions for early Space Station satellite servicing. Volume 2: Technical

NASA Technical Reports Server (NTRS)

Cable, D. A.; Diewald, C. A.; Hills, T. C.; Parmentier, T. J.; Spencer, R. A.; Stone, G. E.

1984-01-01

Volume 2 contains the Technical Report of the approach and results of the Phase 2 study. The phase 2 servicing study was initiated in June 1983, and is being reported in this document. The scope of the contract was to: (1) define in detail five selected technology development missions (TDM); (2) conduct a design requirement analysis to refine definitions of satellite servicing requirements at the space station; and (3) develop a technology plan that would identify and schedule prerequisite precursor technology development, associated. STS flight experiments and space station experiments needed to provide onorbit validation of the evolving technology.

A current perspective on medical informatics and health sciences librarianship.

PubMed

Perry, Gerald J; Roderer, Nancy K; Assar, Soraya

2005-04-01

The article offers a current perspective on medical informatics and health sciences librarianship. The authors: (1) discuss how definitions of medical informatics have changed in relation to health sciences librarianship and the broader domain of information science; (2) compare the missions of health sciences librarianship and health sciences informatics, reviewing the characteristics of both disciplines; (3) propose a new definition of health sciences informatics; (4) consider the research agendas of both disciplines and the possibility that they have merged; and (5) conclude with some comments about actions and roles for health sciences librarians to flourish in the biomedical information environment of today and tomorrow. Boundaries are disappearing between the sources and types of and uses for health information managed by informaticians and librarians. Definitions of the professional domains of each have been impacted by these changes in information. Evolving definitions reflect the increasingly overlapping research agendas of both disciplines. Professionals in these disciplines are increasingly functioning collaboratively as "boundary spanners," incorporating human factors that unite technology with health care delivery.

The kinetics of pre-mRNA splicing in the Drosophila genome and the influence of gene architecture.

PubMed

Pai, Athma A; Henriques, Telmo; McCue, Kayla; Burkholder, Adam; Adelman, Karen; Burge, Christopher B

2017-12-27

Production of most eukaryotic mRNAs requires splicing of introns from pre-mRNA. The splicing reaction requires definition of splice sites, which are initially recognized in either intron-spanning ('intron definition') or exon-spanning ('exon definition') pairs. To understand how exon and intron length and splice site recognition mode impact splicing, we measured splicing rates genome-wide in Drosophila , using metabolic labeling/RNA sequencing and new mathematical models to estimate rates. We found that the modal intron length range of 60-70 nt represents a local maximum of splicing rates, but that much longer exon-defined introns are spliced even faster and more accurately. We observed unexpectedly low variation in splicing rates across introns in the same gene, suggesting the presence of gene-level influences, and we identified multiple gene level variables associated with splicing rate. Together our data suggest that developmental and stress response genes may have preferentially evolved exon definition in order to enhance the rate or accuracy of splicing.

Timing of definitive fixation of major long bone fractures: Can fat embolism syndrome be prevented?

PubMed

Blokhuis, Taco J; Pape, Hans-Christoph; Frölke, Jan-Paul

2017-06-01

Fat embolism is common in patients with major fractures, but leads to devastating consequences, named fat embolism syndrome (FES) in some. Despite advances in treatment strategies regarding the timing of definitive fixation of major fractures, FES still occurs in patients. In this overview, current literature is reviewed and optimal treatment strategies for patients with multiple traumatic injuries, including major fractures, are discussed. Considering the multifactorial etiology of FES, including mechanical and biochemical pathways, FES cannot be prevented in all patients. However, screening for symptoms of FES should be standard in the pre-operative work-up of these patients, prior to definitive fixation of major fractures. Copyright © 2017. Published by Elsevier Ltd.

78 FR 12621 - Control of Communicable Diseases: Interstate; Scope and Definitions

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-25

... Control of Communicable Diseases: Interstate; Scope and Definitions AGENCY: Centers for Disease Control... effective date of Direct Final Rule. SUMMARY: The Centers for Disease Control and Prevention (CDC) within... Disease [[Page 12622

Notable Aspects of Glycan-Protein Interactions

PubMed Central

Cohen, Miriam

2015-01-01

This mini review highlights several interesting aspects of glycan-mediated interactions that are common between cells, bacteria, and viruses. Glycans are ubiquitously found on all living cells, and in the extracellular milieu of multicellular organisms. They are known to mediate initial binding and recognition events of both immune cells and pathogens with their target cells or tissues. The host target tissues are hidden under a layer of secreted glycosylated decoy targets. In addition, pathogens can utilize and display host glycans to prevent identification as foreign by the host’s immune system (molecular mimicry). Both the host and pathogens continually evolve. The host evolves to prevent infection and the pathogens evolve to evade host defenses. Many pathogens express both glycan-binding proteins and glycosidases. Interestingly, these proteins are often located at the tip of elongated protrusions in bacteria, or in the leading edge of the cell. Glycan-protein interactions have low affinity and, as a result, multivalent interactions are often required to achieve biologically relevant binding. These enable dynamic forms of adhesion mechanisms, reviewed here, and include rolling (cells), stick and roll (bacteria) or surfacing (viruses). PMID:26340640

A Discussion of Oxygen Recovery Definitions and Key Performance Parameters for Closed-Loop Atmosphere Revitalization Life Support Technology Development

NASA Technical Reports Server (NTRS)

Abney, Morgan B.; Perry, Jay L.

2016-01-01

Over the last 55 years, NASA has evolved life support for crewed space exploration vehicles from simple resupply during Project Mercury to the complex and highly integrated system of systems aboard the International Space Station. As NASA targets exploration destinations farther from low Earth orbit and mission durations of 500 to 1000 days, life support systems must evolve to meet new requirements. In addition to having more robust, reliable, and maintainable hardware, limiting resupply becomes critical for managing mission logistics and cost. Supplying a crew with the basics of food, water, and oxygen become more challenging as the destination ventures further from Earth. Aboard ISS the Atmosphere Revitalization Subsystem (ARS) supplies the crew's oxygen demand by electrolyzing water. This approach makes water a primary logistics commodity that must be managed carefully. Chemical reduction of metabolic carbon dioxide (CO2) provides a method of recycling oxygen thereby reducing the net ARS water demand and therefore minimizing logistics needs. Multiple methods have been proposed to achieve this recovery and have been reported in the literature. However, depending on the architecture and the technology approach, "oxygen recovery" can be defined in various ways. This discontinuity makes it difficult to compare technologies directly. In an effort to clarify community discussions of Oxygen Recovery, we propose specific definitions and describe the methodology used to arrive at those definitions. Additionally, we discuss key performance parameters for Oxygen Recovery technology development including challenges with comparisons to state-of-the-art.

What Is Stochastic Resonance? Definitions, Misconceptions, Debates, and Its Relevance to Biology

PubMed Central

McDonnell, Mark D.; Abbott, Derek

2009-01-01

Stochastic resonance is said to be observed when increases in levels of unpredictable fluctuations—e.g., random noise—cause an increase in a metric of the quality of signal transmission or detection performance, rather than a decrease. This counterintuitive effect relies on system nonlinearities and on some parameter ranges being “suboptimal”. Stochastic resonance has been observed, quantified, and described in a plethora of physical and biological systems, including neurons. Being a topic of widespread multidisciplinary interest, the definition of stochastic resonance has evolved significantly over the last decade or so, leading to a number of debates, misunderstandings, and controversies. Perhaps the most important debate is whether the brain has evolved to utilize random noise in vivo, as part of the “neural code”. Surprisingly, this debate has been for the most part ignored by neuroscientists, despite much indirect evidence of a positive role for noise in the brain. We explore some of the reasons for this and argue why it would be more surprising if the brain did not exploit randomness provided by noise—via stochastic resonance or otherwise—than if it did. We also challenge neuroscientists and biologists, both computational and experimental, to embrace a very broad definition of stochastic resonance in terms of signal-processing “noise benefits”, and to devise experiments aimed at verifying that random variability can play a functional role in the brain, nervous system, or other areas of biology. PMID:19562010

Scientific Scope | Division of Cancer Prevention

Cancer.gov

The Division of Cancer Prevention conducts and supports research to determine a person's risk of developing cancer and to find ways to reduce that risk. Through laboratory, clinical, and epidemiologic research, scientists have shown that the diseases of cancer occur not as single, catastrophic events, but rather as the result of a complex and long-evolving molecular process

State of the Art: Novel Applications for Cortical Stimulation.

PubMed

De Ridder, Dirk; Perera, Sanjaya; Vanneste, Sven

2017-04-01

Electrical stimulation via implanted electrodes that overlie the cortex of the brain is an upcoming neurosurgical technique that was hindered for a long time by insufficient knowledge of how the brain functions in a dynamic, physiological, and pathological way, as well as by technological limitations of the implantable stimulation devices. This paper provides an overview of cortex stimulation via implantable devices and introduces future possibilities to improve cortex stimulation. Cortex stimulation was initially used preoperatively as a technique to localize functions in the brain and only later evolved into a treatment technique. It was first used for pain, but more recently a multitude of pathologies are being targeted by cortex stimulation. These disorders are being treated by stimulating different cortical areas of the brain. Risks and complications are essentially similar to those related to deep brain stimulation and predominantly include haemorrhage, seizures, infection, and hardware failures. For cortex stimulation to fully mature, further technological development is required to predict its outcomes and improve stimulation designs. This includes the development of network science-based functional connectivity approaches, genetic analyses, development of navigated high definition transcranial alternating current stimulation, and development of pseudorandom stimulation designs for preventing habituation. In conclusion, cortex stimulation is a nascent but very promising approach to treating a variety of diseases, but requires further technological development for predicting outcomes, such as network science based functional connectivity approaches, genetic analyses, development of navigated transcranial electrical stimulation, and development of pseudorandom stimulation designs for preventing habituation. © 2017 International Neuromodulation Society.

26 CFR 1.175-2 - Definition of soil and water conservation expenditures.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 26 Internal Revenue 3 2010-04-01 2010-04-01 false Definition of soil and water conservation... (continued) § 1.175-2 Definition of soil and water conservation expenditures. (a) Expenditures treated as a... of soil or water conservation in respect of land used in farming, or for the prevention of erosion of...

77 FR 63736 - Approval and Promulgation of Air Quality Implementation Plans; West Virginia; Prevention of...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-17

... matter in the definition of ``regulated NSR pollutant'' found at 45CSR14 section 2.66. Except for this... requirement to include condensable emissions of particulate matter in the definition of ``regulated NSR... particulate matter in the definition of ``regulated NSR pollutant'' found at 45CSR14 section 2.66...

78 FR 63435 - Approval and Promulgation of Air Quality Implementation Plans; Rhode Island: Prevention of...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-10-24

... also proposing to fully approve the State's definition of ``PM 2.5 '' (fine particulate matter) which is specific only to permitting. Certain of the State's SIP revisions consist of definitions that also... pollutants other than GHGs. EPA is proposing to conditionally approve those definitions as they relate to the...

Cognitive Offloading Does Not Prevent but Rather Promotes Cognitive Development

PubMed Central

Nolfi, Stefano

2016-01-01

We investigate the relation between the development of reactive and cognitive capabilities. In particular we investigate whether the development of reactive capabilities prevents or promotes the development of cognitive capabilities in a population of evolving robots that have to solve a time-delay navigation task in a double T-Maze environment. Analysis of the experiments reveals that the evolving robots always select reactive strategies that rely on cognitive offloading, i.e., the possibility of acting so as to encode onto the relation between the agent and the environment the states that can be used later to regulate the agent’s behavior. The discovery of these strategies does not prevent, but rather facilitates, the development of cognitive strategies that also rely on the extraction and use of internal states. Detailed analysis of the results obtained in the different experimental conditions provides evidence that helps clarify why, contrary to expectations, reactive and cognitive strategies tend to have synergetic relationships. PMID:27505162

7 CFR 305.1 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-01-01

... ionizing radiation. Methyl bromide. A colorless, odorless biocide used to fumigate a wide range of commodities. Neutralize. To prevent the establishment of a plant pest by killing it, sterilizing it, preventing its development from an immature stage, or preventing its emergence from its host. Plant...

A Case Study of the De Novo Evolution of a Complex Odometric Behavior in Digital Organisms

PubMed Central

Grabowski, Laura M.; Bryson, David M.; Dyer, Fred C.; Pennock, Robert T.; Ofria, Charles

2013-01-01

Investigating the evolution of animal behavior is difficult. The fossil record leaves few clues that would allow us to recapitulate the path that evolution took to build a complex behavior, and the large population sizes and long time scales required prevent us from re-evolving such behaviors in a laboratory setting. We present results of a study in which digital organisms–self-replicating computer programs that are subject to mutations and selection–evolved in different environments that required information about past experience for fitness-enhancing behavioral decisions. One population evolved a mechanism for step-counting, a surprisingly complex odometric behavior that was only indirectly related to enhancing fitness. We examine in detail the operation of the evolved mechanism and the evolutionary transitions that produced this striking example of a complex behavior. PMID:23577113

42 CFR 50.302 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Abortions and Related Medical Services in Federally Assisted Programs of the Public Health Service § 50.302... medical service, including an abortion, performed for the purpose of preventing or terminating a pregnancy... of abortions is specifically excluded from this definition. ...

42 CFR 50.302 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-10-01

... Abortions and Related Medical Services in Federally Assisted Programs of the Public Health Service § 50.302... medical service, including an abortion, performed for the purpose of preventing or terminating a pregnancy... of abortions is specifically excluded from this definition. ...

42 CFR 50.302 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-10-01

... Abortions and Related Medical Services in Federally Assisted Programs of the Public Health Service § 50.302... medical service, including an abortion, performed for the purpose of preventing or terminating a pregnancy... of abortions is specifically excluded from this definition. ...

42 CFR 50.302 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Abortions and Related Medical Services in Federally Assisted Programs of the Public Health Service § 50.302... medical service, including an abortion, performed for the purpose of preventing or terminating a pregnancy... of abortions is specifically excluded from this definition. ...

42 CFR 50.302 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-10-01

... Abortions and Related Medical Services in Federally Assisted Programs of the Public Health Service § 50.302... medical service, including an abortion, performed for the purpose of preventing or terminating a pregnancy... of abortions is specifically excluded from this definition. ...

The definition of mental disorder: evolving but dysfunctional?

PubMed

Bingham, Rachel; Banner, Natalie

2014-08-01

Extensive and diverse conceptual work towards developing a definition of 'mental disorder' was motivated by the declassification of homosexuality from the Diagnostic and Statistical Manual in 1973. This highly politicised event was understood as a call for psychiatry to provide assurances against further misclassification on the basis of discrimination or socio-political deviance. Today, if a definition of mental disorder fails to exclude homosexuality, then it fails to provide this safeguard against potential abuses and therefore fails to do an important part of the work it was intended to do. We argue that fact-based definitions of mental disorder, relying on scientific theory, fail to offer a robust definition of mental disorder that excludes homosexuality. Definitions of mental disorder based on values do not fare better: these definitions are silent on questions about the diagnostic status of individuals in oppressive societies and over-inclusive of mental or behavioural states that happen to be negatively valued in the individual's social context. We consider the latest definition proposed for the Diagnostic and Statistical Manual-5 (DSM-5) in light of these observations. We argue that definition fails to improve on these earlier deficiencies. Its inclusion in the manual may offer false reassurance against repetition of past misclassifications. We conclude with a provocation that if candidate definitions of mental disorder are unable to exclude homosexuality, it might perhaps be preferable not to attempt a definition at all. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

Origins of multicellular evolvability in snowflake yeast

PubMed Central

Ratcliff, William C.; Fankhauser, Johnathon D.; Rogers, David W.; Greig, Duncan; Travisano, Michael

2015-01-01

Complex life has arisen through a series of ‘major transitions’ in which collectives of formerly autonomous individuals evolve into a single, integrated organism. A key step in this process is the origin of higher-level evolvability, but little is known about how higher-level entities originate and gain the capacity to evolve as an individual. Here we report a single mutation that not only creates a new level of biological organization, but also potentiates higher-level evolvability. Disrupting the transcription factor ACE2 in Saccharomyces cerevisiae prevents mother–daughter cell separation, generating multicellular ‘snowflake’ yeast. Snowflake yeast develop through deterministic rules that produce geometrically defined clusters that preclude genetic conflict and display a high broad-sense heritability for multicellular traits; as a result they are preadapted to multicellular adaptation. This work demonstrates that simple microevolutionary changes can have profound macroevolutionary consequences, and suggests that the formation of clonally developing clusters may often be the first step to multicellularity. PMID:25600558

Defining and measuring patient safety.

PubMed

Pronovost, Peter J; Thompson, David A; Holzmueller, Christine G; Lubomski, Lisa H; Morlock, Laura L

2005-01-01

Despite the growing demand for improved safety in health care, debate remains regarding the magnitude of the problem and the degree to which harm is preventable. To a great extent, this debate stems from variation in the definition and methods for measuring safety, its "shadow" error, and the degree of preventability. This article reviews the definition of safety and error, discusses approaches to measuring safety, and provides a framework for investigating incidents that unveils how the systems under which care is delivered may contribute to adverse incidents.

Situational Awareness -- Evolving Knowledge into Understanding: A Competency Critical to US National Interest

DTIC Science & Technology

2009-05-01

implications and practical consequences Communicates effectively with others in determining solutions to complex problems.” 20...and communicating • it becomes possible for certain skills to be performed while doing something else; for example, knitting while watching...has been employed extensively in the aeronautical, space and intelligence communities . Yet there is no single mutually acceptable definition of SA

Device Comparability of Tablets and Computers for Assessment Purposes

ERIC Educational Resources Information Center

Davis, Laurie Laughlin; Kong, Xiaojing; McBride, Yuanyuan; Morrison, Kristin M.

2017-01-01

The definition of what it means to take a test online continues to evolve with the inclusion of a broader range of item types and a wide array of devices used by students to access test content. To assure the validity and reliability of test scores for all students, device comparability research should be conducted to evaluate the impact of…

Exploitation: One View of Industry and Business. Training and Development Research Center: Project Number Ten.

ERIC Educational Resources Information Center

Swanson, Richard A.; And Others

A reasonable definition of exploitation is an unjust or improper use of another person for one's own profit or advantage. Exploitation predates the age of industry; it is not the sole province of industry and business. Worker responses to exploitation in the evolving industrial democracy have taken the form of labor unions, political clubs, credit…

Re-evaluation of cosmic ray cutoff terminology

NASA Technical Reports Server (NTRS)

Cooke, D. J.; Humble, J. E.; Shea, M. A.; Smart, D. F.; Lund, N.; Rasmussen, I. L.; Byrnak, B.; Goret, P.; Petrou, N.

1985-01-01

The study of cosmic ray access to locations inside the geomagnetic field has evolved in a manner that has led to some misunderstanding and misapplication of the terminology originally developed to describe particle access. This paper presents what is believed to be a useful set of definitions for cosmic ray cutoff terminology for use in theoretical and experimental cosmic ray studies.

An Old-Growth Definition for Western and Mixed Mesophytic Forests

Treesearch

Cathryn H. Greenberg; Donald E. McLeod; David L. Loftis

1997-01-01

Old growth is widely acknowledged today as an essential part of managed forests, particularly on public lands. However, this concept is relatively new, evolving since the 1970's when a grassroots movement in the Pacific Northwest began in earnest to define old growth. In response to changes in public attitude, the U.S. Department of Agriculture, Forest Service,...

Beyond Recycling: Guiding Preservice Teachers to Understand and Incorporate the Deeper Principles of Sustainability

ERIC Educational Resources Information Center

Bauermeister, Maxine L.; Diefenbacher, Lori H.

2015-01-01

Sustainability is a term with an evolving definition that applies to more than the physical environment. It speaks to the interconnectivity of every action we take (or fail to take) and to human beings' relationships with one another and their environment. A sustainable future is one in which global citizens engage in critical thinking,…

Synthesis Guidebook. Volume 1. Methodology Definition

DTIC Science & Technology

1992-10-16

OV I. Introductiaa " Synthesis Transition Strategies (Williams 1990b), which discusses a strategy for the incremental transitioning of Synthesis into... strategies for mitigating those risks. Use checkpoints, reviews, and metrics to reveal flaws and misconceptions. 4. Interaction With Other Activities... markets and customer requirements lead to evolving product and process needs of Application Engineering projects. OV2-5 OV.2. Fundamentals of Synthesis

An Evolving Curriculum: The Technical Core of Hispanic-Serving Institutions in the State of Texas

ERIC Educational Resources Information Center

Satterfield, James; Rincones, Rodolfo Delgado

2008-01-01

Although there is extensive research pertaining to Hispanic Serving Institutions (HSI), it is primarily framed around the U.S. federal definition of Hispanic Serving Institutions established by Title V of the Higher Education Act of 1965. This law identifies HSI as institutions that have a Hispanic student population of at least 25 percent and…

Convergent Evolution of Health Information Management and Health Informatics

PubMed Central

Gibson, C. J.; Abrams, K.

2015-01-01

Summary Clearly defined boundaries are disappearing among the activities, sources, and uses of health care data and information managed by health information management (HIM) and health informatics (HI) professionals. Definitions of the professional domains and scopes of practice for HIM and HI are converging with the proliferation of information and communication technologies in health care settings. Convergence is changing both the roles that HIM and HI professionals serve in their organizations as well as the competencies necessary for training future professionals. Many of these changes suggest a blurring of roles and responsibilities with increasingly overlapping curricula, job descriptions, and research agendas. Blurred lines in a highly competitive market create confusion for students and employers. In this essay, we provide some perspective on the changing landscape and suggest a course for the future. First we review the evolving definitions of HIM and HI. We next compare the current domains and competencies, review the characteristics as well as the education and credentialing of both disciplines, and examine areas of convergence. Given the current state, we suggest a path forward to strengthen the contributions HIM and HI professionals and educators make to the evolving health care environment. PMID:25848421

HIV Programs for Sex Workers: Lessons and Challenges for Developing and Delivering Programs

PubMed Central

Wilson, David

2015-01-01

There is evidence that HIV prevention programs for sex workers, especially female sex workers, are cost-effective in several contexts, including many western countries, Thailand, India, the Democratic Republic of Congo, Kenya, and Zimbabwe. The evidence that sex worker HIV prevention programs work must not inspire complacency but rather a renewed effort to expand, intensify, and maximize their impact. The PLOS Collection “Focus on Delivery and Scale: Achieving HIV Impact with Sex Workers” highlights major challenges to scaling-up sex worker HIV prevention programs, noting the following: sex worker HIV prevention programs are insufficiently guided by understanding of epidemic transmission dynamics, situation analyses, and programmatic mapping; sex worker HIV and sexually transmitted infection services receive limited domestic financing in many countries; many sex worker HIV prevention programs are inadequately codified to ensure consistency and quality; and many sex worker HIV prevention programs have not evolved adequately to address informal sex workers, male and transgender sex workers, and mobile- and internet-based sex workers. Based on the wider collection of papers, this article presents three major clusters of recommendations: (i) HIV programs focused on sex workers should be prioritized, developed, and implemented based on robust evidence; (ii) national political will and increased funding are needed to increase coverage of effective sex worker HIV prevention programs in low and middle income countries; and (iii) comprehensive, integrated, and rapidly evolving HIV programs are needed to ensure equitable access to health services for individuals involved in all forms of sex work. PMID:26079267

HIV Programs for Sex Workers: Lessons and Challenges for Developing and Delivering Programs.

PubMed

Wilson, David

2015-06-01

There is evidence that HIV prevention programs for sex workers, especially female sex workers, are cost-effective in several contexts, including many western countries, Thailand, India, the Democratic Republic of Congo, Kenya, and Zimbabwe. The evidence that sex worker HIV prevention programs work must not inspire complacency but rather a renewed effort to expand, intensify, and maximize their impact. The PLOS Collection "Focus on Delivery and Scale: Achieving HIV Impact with Sex Workers" highlights major challenges to scaling-up sex worker HIV prevention programs, noting the following: sex worker HIV prevention programs are insufficiently guided by understanding of epidemic transmission dynamics, situation analyses, and programmatic mapping; sex worker HIV and sexually transmitted infection services receive limited domestic financing in many countries; many sex worker HIV prevention programs are inadequately codified to ensure consistency and quality; and many sex worker HIV prevention programs have not evolved adequately to address informal sex workers, male and transgender sex workers, and mobile- and internet-based sex workers. Based on the wider collection of papers, this article presents three major clusters of recommendations: (i) HIV programs focused on sex workers should be prioritized, developed, and implemented based on robust evidence; (ii) national political will and increased funding are needed to increase coverage of effective sex worker HIV prevention programs in low and middle income countries; and (iii) comprehensive, integrated, and rapidly evolving HIV programs are needed to ensure equitable access to health services for individuals involved in all forms of sex work.

Characteristics of non-fatal abusive head trauma among children in the USA, 2003--2008: application of the CDC operational case definition to national hospital inpatient data.

PubMed

Parks, Sharyn; Sugerman, David; Xu, Likang; Coronado, Victor

2012-12-01

An International Classification of Diseases code-based case definition for non-fatal abusive head trauma (AHT) in children <5 years of age was developed in March 2008 by an expert panel convened at the Centers for Disease Control and Prevention (CDC). This study presents an application of the CDC recommended operational case definition of AHT to US hospital inpatient data to characterise the AHT hospitalisation rate for children <5 years of age. Nationwide Inpatient Sample (NIS) data from the Healthcare Cost and Utilisation Project from 2003 to 2008 were examined. Inspection of the NIS data resulted in the identification of an estimated 10 555 non-fatal AHT hospitalisations with 9595 classified as definite/presumptive AHT and 960 classified as probable AHT. The non-fatal AHT rate was highest among children aged <1 year (32.3 per 100 000) with a peak in hospitalisations between 1 and 3 months of age. Non-fatal AHT hospitalisation rates for children <2 years of age were higher for boys (21.9 per 100 000) than girls (15.3 per 100 000). The non-fatal AHT hospitalisation rate showed little variation across seasons. To reduce the burden of AHT in the USA, a preventable public health problem, concerted prevention efforts targeting populations at risk should be implemented. This report demonstrates a model procedure for using the new CDC definition for public health surveillance and research purposes. Such findings can be used to inform parents and providers about AHT (eg, dangers of shaking, strategies for managing infant crying) as well as to monitor better the impact of prevention strategies over time.

Characteristics of non-fatal abusive head trauma among children in the USA, 2003–2008: application of the CDC operational case definition to national hospital inpatient data

PubMed Central

Parks, Sharyn; Sugerman, David; Xu, Likang; Coronado, Victor

2016-01-01

Objective An International Classification of Diseases code-based case definition for non-fatal abusive head trauma (AHT) in children <5 years of age was developed in March 2008 by an expert panel convened at the Centers for Disease Control and Prevention (CDC). This study presents an application of the CDC recommended operational case definition of AHT to US hospital inpatient data to characterise the AHT hospitalisation rate for children <5 years of age. Methods Nationwide Inpatient Sample (NIS) data from the Healthcare Cost and Utilisation Project from 2003 to 2008 were examined. Results Inspection of the NIS data resulted in the identification of an estimated 10 555 non-fatal AHT hospitalisations with 9595 classified as definite/presumptive AHT and 960 classified as probable AHT. The non-fatal AHT rate was highest among children aged <1 year (32.3 per 100 000) with a peak in hospitalisations between 1 and 3 months of age. Non-fatal AHT hospitalisation rates for children <2 years of age were higher for boys (21.9 per 100 000) than girls (15.3 per 100 000). The non-fatal AHT hospitalisation rate showed little variation across seasons. Conclusions To reduce the burden of AHT in the USA, a preventable public health problem, concerted prevention efforts targeting populations at risk should be implemented. This report demonstrates a model procedure for using the new CDC definition for public health surveillance and research purposes. Such findings can be used to inform parents and providers about AHT (eg, dangers of shaking, strategies for managing infant crying) as well as to monitor better the impact of prevention strategies over time. PMID:22328632

Developing a comprehensive definition of sustainability.

PubMed

Moore, Julia E; Mascarenhas, Alekhya; Bain, Julie; Straus, Sharon E

2017-09-02

Understanding sustainability is one of the significant implementation science challenges. One of the big challenges in researching sustainability is the lack of consistent definitions in the literature. Most implementation studies do not present a definition of sustainability, even when assessing sustainability. The aim of the current study was to systematically develop a comprehensive definition of sustainability based on definitions already used in the literature. We searched for knowledge syntheses of sustainability and abstracted sustainability definitions from the articles identified through any relevant systematic and scoping reviews. The constructs in the abstracted sustainability definitions were mapped to an existing definition. The comprehensive definition of sustainability was revised to include emerging constructs. We identified four knowledge syntheses of sustainability, which identified 209 original articles. Of the 209 articles, 24 (11.5%) included a definition of sustainability. These definitions were mapped to three constructs from an existing definition, and nine new constructs emerged. We reviewed all constructs and created a revised definition: (1) after a defined period of time, (2) a program, clinical intervention, and/or implementation strategies continue to be delivered and/or (3) individual behavior change (i.e., clinician, patient) is maintained; (4) the program and individual behavior change may evolve or adapt while (5) continuing to produce benefits for individuals/systems. All 24 definitions were remapped to the comprehensive definition (percent agreement among three coders was 94%). Of the 24 definitions, 17 described the continued delivery of a program (70.8%), 17 mentioned continued outcomes (70.8%), 13 mentioned time (54.2%), 8 addressed the individual maintenance of a behavior change (33.3%), and 6 described the evolution or adaptation (25.0%). We drew from over 200 studies to identify 24 existing definitions of sustainability. Based on these definitions, we identified five key sustainability constructs, which can be used as the basis for future research on sustainability. Our next step is to identify sustainability frameworks and develop a meta-framework using a concept mapping approach to consolidate the factors and considerations across sustainability frameworks.

42 CFR 440.130 - Diagnostic, screening, preventive, and rehabilitative services.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 42 Public Health 4 2011-10-01 2011-10-01 false Diagnostic, screening, preventive, and rehabilitative services. 440.130 Section 440.130 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES... Definitions § 440.130 Diagnostic, screening, preventive, and rehabilitative services. (a) “Diagnostic services...

Introduction and Rationale for Individualized Substance Abuse Prevention from an Ontogenetic Perspective

PubMed Central

Ridenour, Ty A.; Stormshak, Elizabeth A.

2009-01-01

Background Progress in substance abuse prevention science could be accelerated by more closely aligning studies, methodologies, and intervention program testing with the ontogenetic orientations of its underlying theories and etiology research. This article introduces the Ontogenetic Prevention approach, describes some aspects of what this orientation offers for substance abuse prevention, and provides an overview of this full special issue. Methods Review of the substance abuse prevention literature illustrates specific aspects of Ontogenetic Prevention. Conclusions The Ontogenetic Prevention perspective and each of the manuscripts in this special issue provide channels whereby substance abuse prevention can evolve from a science that relies largely on universal intervention to diversification for meeting the needs of individuals under specific developmental circumstances. PMID:20180671

The Warburg effect version 2.0

PubMed Central

Menendez, Javier A.; Joven, Jorge; Cufí, Sílvia; Corominas-Faja, Bruna; Oliveras-Ferraros, Cristina; Cuyàs, Elisabet; Martin-Castillo, Begoña; López-Bonet, Eugeni; Alarcón, Tomás; Vazquez-Martin, Alejandro

2013-01-01

When fighting cancer, knowledge on metabolism has always been important. Today, it matters more than ever. The restricted cataloging of cancer genomes is quite unlikely to achieve the task of curing cancer, unless it is integrated into metabolic networks that respond to and influence the constantly evolving cancer stem cell (CSC) cellular states. Once the genomic era of carcinogenesis had pushed the 1920s Otto Warburg’s metabolic cancer hypothesis into obscurity for decades, the most recent studies begin to support a new developing paradigm, in which the molecular logic behind the conversion of non-CSCs into CSCs can be better understood in terms of the “metabolic facilitators” and “metabolic impediments” that operate as proximate openings and roadblocks, respectively, for the transcriptional events and signal transduction programs that ultimately orchestrate the intrinsic and/or microenvironmental paths to CSC cellular states. Here we propose that a profound understanding of how human carcinomas install a proper “Warburg effect version 2.0” allowing them to “run” the CSCs’ “software” programs should guide a new era of metabolo-genomic-personalized cancer medicine. By viewing metabolic reprogramming of CSCs as an essential characteristic that allows dynamic, multidimensional and evolving cancer populations to compete successfully for their expansion on the organism, we now argue that CSCs bioenergetics might be another cancer hallmark. A definitive understanding of metabolic reprogramming in CSCs may complement or to some extent replace, the 30-y-old paradigm of targeting oncogenes to treat human carcinomas, because it can be possible to metabolically create non-permissive or “hostile” metabotypes to prevent the occurrence of CSC cellular states with tumor- and metastasis-initiating capacity. PMID:23549172

Evolving the machine

NASA Astrophysics Data System (ADS)

Bailey, Brent Andrew

Structural designs by humans and nature are wholly distinct in their approaches. Engineers model components to verify that all mechanical requirements are satisfied before assembling a product. Nature, on the other hand; creates holistically: each part evolves in conjunction with the others. The present work is a synthesis of these two design approaches; namely, spatial models that evolve. Topology optimization determines the amount and distribution of material within a model; which corresponds to the optimal connectedness and shape of a structure. Smooth designs are obtained by using higher-order B-splines in the definition of the material distribution. Higher-fidelity is achieved using adaptive meshing techniques at the interface between solid and void. Nature is an exemplary basis for mass minimization, as processing material requires both resources and energy. Topological optimization techniques were originally formulated as the maximization of the structural stiffness subject to a volume constraint. This research inverts the optimization problem: the mass is minimized subject to deflection constraints. Active materials allow a structure to interact with its environment in a manner similar to muscles and sensory organs in animals. By specifying the material properties and design requirements, adaptive structures with integrated sensors and actuators can evolve.

Modular interdependency in complex dynamical systems.

PubMed

Watson, Richard A; Pollack, Jordan B

2005-01-01

Herbert A. Simon's characterization of modularity in dynamical systems describes subsystems as having dynamics that are approximately independent of those of other subsystems (in the short term). This fits with the general intuition that modules must, by definition, be approximately independent. In the evolution of complex systems, such modularity may enable subsystems to be modified and adapted independently of other subsystems, whereas in a nonmodular system, modifications to one part of the system may result in deleterious side effects elsewhere in the system. But this notion of modularity and its effect on evolvability is not well quantified and is rather simplistic. In particular, modularity need not imply that intermodule dependences are weak or unimportant. In dynamical systems this is acknowledged by Simon's suggestion that, in the long term, the dynamical behaviors of subsystems do interact with one another, albeit in an "aggregate" manner--but this kind of intermodule interaction is omitted in models of modularity for evolvability. In this brief discussion we seek to unify notions of modularity in dynamical systems with notions of how modularity affects evolvability. This leads to a quantifiable measure of modularity and a different understanding of its effect on evolvability.

Membrane water deaerator investigation. [fluid filter breadboard model

NASA Technical Reports Server (NTRS)

Elam, J.; Ruder, J.; Strumpf, H.

1974-01-01

The purpose of the membrane water deaerator program was to develop data on a breadboard hollow fiber membrane unit that removes both dissolved and evolved gas from a water transfer system in order to: (1) assure a hard fill of the EVLSS expendable water tank; (2) prevent flow blockage by gas bubbles in circulating systems; and (3) prevent pump cavitation.

Do extraterrestrials have sex (and intelligence)?

PubMed

Barkow, J H

2000-04-01

This thought experiment addresses the range of possible evolved psychologies likely to be associated with extraterrestrial (ET) intelligence. The analysis rests on: (1) a number of assumptions shared by the SETI project; (2) recent arguments concerning convergent evolution; and (3) current theories of how intelligence evolved in our own species. It concludes that, regardless of how and which cognitive abilities arise initially, extraterrestrially they can develop into intelligence only if an amplification process involving a form of predation and/or sexual selection occurs. Depending on the amplification process, ETs may be xenophobic; however, it is more probable that they will be ethnocentric. Their ideas of reciprocity and fairness are likely to at least overlap with our own. They will definitely be culture-bearing and probably have two sexes, both of which are intelligent. Regardless of the degree of physical similarity of ETs to ourselves, convergence makes it likely that we will at least find their evolved psychology similar enough to our own for comprehension.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sager, P.H.

Studies were carried out on the FED Baseline to improve design definition, establish feasibility, and reduce cost. Emphasis was placed on cost reduction, but significant feasibility concerns existed in several areas, and better design definition was required to establish feasibility and provide a better basis for cost estimates. Design definition and feasibility studies included the development of a labyrinth shield ring concept to prevent radiation streaming between the torus spool and the TF coil cryostat. The labyrinth shield concept which was developed reduced radiation streaming sufficiently to permit contact maintenance of the inboard EF coils. Various concepts of preventing arcingmore » between adjacent shield sectors were also explored. It was concluded that installation of copper straps with molybdenum thermal radiation shields would provide the most reliable means of preventing arcing. Other design studies included torus spool electrical/structural concepts, test module shielding, torus seismic response, poloidal conditions in the magnets, disruption characteristics, and eddy current effects. These additional studies had no significant impact on cost but did confirm the feasibility of the basic FED Baseline concept.« less

A semantic-based method for extracting concept definitions from scientific publications: evaluation in the autism phenotype domain.

PubMed

Hassanpour, Saeed; O'Connor, Martin J; Das, Amar K

2013-08-12

A variety of informatics approaches have been developed that use information retrieval, NLP and text-mining techniques to identify biomedical concepts and relations within scientific publications or their sentences. These approaches have not typically addressed the challenge of extracting more complex knowledge such as biomedical definitions. In our efforts to facilitate knowledge acquisition of rule-based definitions of autism phenotypes, we have developed a novel semantic-based text-mining approach that can automatically identify such definitions within text. Using an existing knowledge base of 156 autism phenotype definitions and an annotated corpus of 26 source articles containing such definitions, we evaluated and compared the average rank of correctly identified rule definition or corresponding rule template using both our semantic-based approach and a standard term-based approach. We examined three separate scenarios: (1) the snippet of text contained a definition already in the knowledge base; (2) the snippet contained an alternative definition for a concept in the knowledge base; and (3) the snippet contained a definition not in the knowledge base. Our semantic-based approach had a higher average rank than the term-based approach for each of the three scenarios (scenario 1: 3.8 vs. 5.0; scenario 2: 2.8 vs. 4.9; and scenario 3: 4.5 vs. 6.2), with each comparison significant at the p-value of 0.05 using the Wilcoxon signed-rank test. Our work shows that leveraging existing domain knowledge in the information extraction of biomedical definitions significantly improves the correct identification of such knowledge within sentences. Our method can thus help researchers rapidly acquire knowledge about biomedical definitions that are specified and evolving within an ever-growing corpus of scientific publications.

40 CFR 59.402 - VOC content limits.

Code of Federal Regulations, 2014 CFR

2014-07-01

... marking coatings. (17) Rust preventative coatings that also meet the definition for primers or undercoaters are subject only to the VOC content limit in table 1 of this subpart for rust preventative...

40 CFR 59.402 - VOC content limits.

Code of Federal Regulations, 2013 CFR

2013-07-01

... marking coatings. (17) Rust preventative coatings that also meet the definition for primers or undercoaters are subject only to the VOC content limit in table 1 of this subpart for rust preventative...

40 CFR 59.402 - VOC content limits.

Code of Federal Regulations, 2010 CFR

2010-07-01

... marking coatings. (17) Rust preventative coatings that also meet the definition for primers or undercoaters are subject only to the VOC content limit in table 1 of this subpart for rust preventative...

40 CFR 59.402 - VOC content limits.

Code of Federal Regulations, 2012 CFR

2012-07-01

... marking coatings. (17) Rust preventative coatings that also meet the definition for primers or undercoaters are subject only to the VOC content limit in table 1 of this subpart for rust preventative...

40 CFR 59.402 - VOC content limits.

Code of Federal Regulations, 2011 CFR

2011-07-01

... marking coatings. (17) Rust preventative coatings that also meet the definition for primers or undercoaters are subject only to the VOC content limit in table 1 of this subpart for rust preventative...

Are Cultural Values and Beliefs Included in U.S. Based HIV Interventions?

PubMed Central

Wyatt, Gail E.; Williams, John K.; Gupta, Arpana; Malebranche, Dominique

2013-01-01

Objective To determine the extent to which current U.S. based HIV/AIDS prevention and risk reduction interventions address and include aspects of cultural beliefs in definitions, curricula, measures and related theories that may contradict current safer sex messages. Method A comprehensive literature review was conducted to determine which published HIV/AIDS prevention and risk reduction interventions incorporated aspects of cultural beliefs. Results This review of 166 HIV prevention and risk reduction interventions, published between 1988 and 2010, identified 34 interventions that varied in cultural definitions and the integration of cultural concepts. Conclusion HIV interventions need to move beyond targeting specific populations based upon race/ethnicity, gender, sexual, drug and/or risk behaviors and incorporate cultural beliefs and experiences pertinent to an individual’s risk. Theory based interventions that incorporate cultural beliefs within a contextual framework are needed if prevention and risk reduction messages are to reach targeted at risk populations. Implications for the lack of uniformity of cultural definitions, measures and related theories are discussed and recommendations are made to ensure that cultural beliefs are acknowledged for their potential conflict with safer sex skills and practices. PMID:21884721

Classification and regulatory perspectives of dietary fiber.

PubMed

Dai, Fan-Jhen; Chau, Chi-Fai

2017-01-01

This review discusses the history and evolution of the state of dietary fiber (DF) with account of refinements in extraction methods and legal definitions subsequent to the launch of DF hypothesis. For a long time, defining and regulating DFs relied heavily on their chemical compositions and analytical methods. Although chemical compositions and analytical methods still play an important role in the definition of DF, physiological activity has also been taken into consideration. The precise definition of DF is still evolving, particularly whether oligosaccharides degrees of polymerization (DP) 3-9 should be considered as DF or not. Decades of scientific research have initiated the expansion of the term DF to include indigestible oligosaccharides with their DP between 3 and 9; hence responding to the positive health benefits of DF as well as fulfilling the needs in food labeling regulations. Copyright © 2016. Published by Elsevier B.V.

Cyberbullying: the challenge to define.

PubMed

Langos, Colette

2012-06-01

Cyberbullying is a reality of the digital age. To address this phenomenon, it becomes imperative to understand exactly what cyberbullying is. Thus, establishing a workable and theoretically sound definition is essential. This article contributes to the existing literature in relation to the definition of cyberbullying. The specific elements of repetition, power imbalance, intention, and aggression, regarded as essential criteria of traditional face-to-face bullying, are considered in the cyber context. It is posited that the core bullying elements retain their importance and applicability in relation to cyberbullying. The element of repetition is in need of redefining, given the public nature of material in the online environment. In this article, a clear distinction between direct and indirect cyberbullying is made and a model definition of cyberbullying is offered. Overall, the analysis provided lends insight into how the essential bullying elements have evolved and should apply in our parallel cyber universe.

Personality, Psychopathology, and Health Through the Lens of Interpersonal Relatedness and Self-Definition.

PubMed

Luyten, Patrick

2017-06-01

Sidney Blatt's seminal contributions in the domain of personality development, psychopathology, and health rank among the best researched and most empirically supported theories in psychoanalysis. Blatt is known primarily for his two-polarities model of personality development, which he viewed as evolving through a dialectical, synergistic interaction between two fundamental processes across the lifespan: the development of interpersonal relatedness on the one hand, and of self-definition on the other. In this model, psychopathology is viewed as an attempt to find a balance, however distorted, between relatedness and self-definition. Neurobiological research has confirmed the intrinsic dialectical relationship between these two processes in the development of the neural circuits subserving these capacities, a finding with important implications for physical health. Research relevant to these ideas is reviewed, and the influence that Blatt's approach has had in reintroducing psychodynamic factors into contemporary psychology and psychiatry, as reflected in DSM-5, is discussed.

[Nursing ethics and new challenges].

PubMed

Barrio, I M; Molina, A; Sánchez, C M; Ayudarte, M L

2006-01-01

The nursing profession has always placed great importance on the ethical requirements linked to its activities. However, the understanding and content to these activities has evolved over the course of history. Two approaches have been developed as the principal issues of nursing ethics: the ethics of virtue and the ethics of principles. The first approach enquires into the attitudes that must be held by a person in order to act as a good nurse. The second follows an inverse course and considers the actions and principles that must be respected in order to be a good professional. An approach that harmonises both perspectives must pose the following questions: What do we understand by nursing care? On what ethical principles is this form of understanding care based? What moral attitudes are related to caring correctly? In a modern professional model, the definition and exercise of care necessarily include consideration of team work. Similarly, carrying out a good caring function, that is to say quality nursing, requires apprenticeship on the one hand, and, on the other, the assimilation of the attitudes that are required in a person involved in caring. Both elements improve the capacity of the professionals to prevent and resolve ethical conflicts in the practice of care.

Big data in global health: improving health in low- and middle-income countries

PubMed Central

Vaillancourt, Samuel; Perry, William; Mannava, Priya; Folaranmi, Temitope; Celi, Leo Anthony

2015-01-01

Abstract Over the last decade, a massive increase in data collection and analysis has occurred in many fields. In the health sector, however, there has been relatively little progress in data analysis and application despite a rapid rise in data production. Given adequate governance, improvements in the quality, quantity, storage and analysis of health data could lead to substantial improvements in many health outcomes. In low- and middle-income countries in particular, the creation of an information feedback mechanism can move health-care delivery towards results-based practice and improve the effective use of scarce resources. We review the evolving definition of big data and the possible advantages of – and problems in – using such data to improve health-care delivery in low- and middle-income countries. The collection of big data as mobile-phone based services improve may mean that development phases required elsewhere can be skipped. However, poor infrastructure may prevent interoperability and the safe use of patient data. An appropriate governance framework must be developed and enforced to protect individuals and ensure that health-care delivery is tailored to the characteristics and values of the target communities. PMID:25767300

40 CFR 112.2 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 22 2014-07-01 2013-07-01 true Definitions. 112.2 Section 112.2 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS OIL POLLUTION PREVENTION... when identifying response systems and equipment in a response plan for the applicable operating...

40 CFR 112.2 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 23 2012-07-01 2012-07-01 false Definitions. 112.2 Section 112.2 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS OIL POLLUTION PREVENTION... when identifying response systems and equipment in a response plan for the applicable operating...

40 CFR 112.2 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 23 2013-07-01 2013-07-01 false Definitions. 112.2 Section 112.2 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS OIL POLLUTION PREVENTION... when identifying response systems and equipment in a response plan for the applicable operating...

40 CFR 35.141 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-07-01

... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS AND OTHER FEDERAL ASSISTANCE STATE AND LOCAL ASSISTANCE Environmental Program Grants Air Pollution Control (section 105) § 35.141 Definitions. In addition...-out, improving, or maintaining programs for the prevention and control of air pollution or...

40 CFR 35.141 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-07-01

... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS AND OTHER FEDERAL ASSISTANCE STATE AND LOCAL ASSISTANCE Environmental Program Grants Air Pollution Control (section 105) § 35.141 Definitions. In addition...-out, improving, or maintaining programs for the prevention and control of air pollution or...

40 CFR 35.141 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS AND OTHER FEDERAL ASSISTANCE STATE AND LOCAL ASSISTANCE Environmental Program Grants Air Pollution Control (section 105) § 35.141 Definitions. In addition...-out, improving, or maintaining programs for the prevention and control of air pollution or...

Evolving gene regulation networks into cellular networks guiding adaptive behavior: an outline how single cells could have evolved into a centralized neurosensory system

PubMed Central

Fritzsch, Bernd; Jahan, Israt; Pan, Ning; Elliott, Karen L.

2014-01-01

Understanding the evolution of the neurosensory system of man, able to reflect on its own origin, is one of the major goals of comparative neurobiology. Details of the origin of neurosensory cells, their aggregation into central nervous systems and associated sensory organs, their localized patterning into remarkably different cell types aggregated into variably sized parts of the central nervous system begin to emerge. Insights at the cellular and molecular level begin to shed some light on the evolution of neurosensory cells, partially covered in this review. Molecular evidence suggests that high mobility group (HMG) proteins of pre-metazoans evolved into the definitive Sox [SRY (sex determining region Y)-box] genes used for neurosensory precursor specification in metazoans. Likewise, pre-metazoan basic helix-loop-helix (bHLH) genes evolved in metazoans into the group A bHLH genes dedicated to neurosensory differentiation in bilaterians. Available evidence suggests that the Sox and bHLH genes evolved a cross-regulatory network able to synchronize expansion of precursor populations and their subsequent differentiation into novel parts of the brain or sensory organs. Molecular evidence suggests metazoans evolved patterning gene networks early and not dedicated to neuronal development. Only later in evolution were these patterning gene networks tied into the increasing complexity of diffusible factors, many of which were already present in pre-metazoans, to drive local patterning events. It appears that the evolving molecular basis of neurosensory cell development may have led, in interaction with differentially expressed patterning genes, to local network modifications guiding unique specializations of neurosensory cells into sensory organs and various areas of the central nervous system. PMID:25416504

Evolving gene regulatory networks into cellular networks guiding adaptive behavior: an outline how single cells could have evolved into a centralized neurosensory system.

PubMed

Fritzsch, Bernd; Jahan, Israt; Pan, Ning; Elliott, Karen L

2015-01-01

Understanding the evolution of the neurosensory system of man, able to reflect on its own origin, is one of the major goals of comparative neurobiology. Details of the origin of neurosensory cells, their aggregation into central nervous systems and associated sensory organs and their localized patterning leading to remarkably different cell types aggregated into variably sized parts of the central nervous system have begun to emerge. Insights at the cellular and molecular level have begun to shed some light on the evolution of neurosensory cells, partially covered in this review. Molecular evidence suggests that high mobility group (HMG) proteins of pre-metazoans evolved into the definitive Sox [SRY (sex determining region Y)-box] genes used for neurosensory precursor specification in metazoans. Likewise, pre-metazoan basic helix-loop-helix (bHLH) genes evolved in metazoans into the group A bHLH genes dedicated to neurosensory differentiation in bilaterians. Available evidence suggests that the Sox and bHLH genes evolved a cross-regulatory network able to synchronize expansion of precursor populations and their subsequent differentiation into novel parts of the brain or sensory organs. Molecular evidence suggests metazoans evolved patterning gene networks early, which were not dedicated to neuronal development. Only later in evolution were these patterning gene networks tied into the increasing complexity of diffusible factors, many of which were already present in pre-metazoans, to drive local patterning events. It appears that the evolving molecular basis of neurosensory cell development may have led, in interaction with differentially expressed patterning genes, to local network modifications guiding unique specializations of neurosensory cells into sensory organs and various areas of the central nervous system.

40 CFR 60.101a - Definitions.

Code of Federal Regulations, 2013 CFR

2013-07-01

... tip to prevent oxygen infiltration (backflow) into the flare tip. For flares with no water seals, the... function of preventing oxygen infiltration (backflow) into the flare tip. [73 FR 35867, June 24, 2008, as...

Commentary on Foubert, Godin, & Tatum (2010): the evolution of sexual violence prevention and the urgency for effectiveness.

PubMed

Tharp, Andra Teten; DeGue, Sarah; Lang, Karen; Valle, Linda Anne; Massetti, Greta; Holt, Melissa; Matjasko, Jennifer

2011-11-01

Foubert, Godin, and Tatum describe qualitative effects among college men of The Men's Program, a one-session sexual violence prevention program. This article and the program it describes are representative of many sexual violence prevention programs that are in practice and provide an opportunity for a brief discussion of the development and evaluation of sexual violence prevention approaches. In this commentary, we will focus on two considerations for an evolving field: the adherence to the principles of prevention and the use of rigorous evaluation methods to demonstrate effectiveness. We argue that the problem of sexual violence has created urgency for effective prevention programs and that scientific and prevention standards provide the best foundation to meet this need.

The Origin of Species by Means of Mathematical Modelling.

PubMed

Bessonov, Nikolai; Reinberg, Natalia; Banerjee, Malay; Volpert, Vitaly

2018-04-30

Darwin described biological species as groups of morphologically similar individuals. These groups of individuals can split into several subgroups due to natural selection, resulting in the emergence of new species. Some species can stay stable without the appearance of a new species, some others can disappear or evolve. Some of these evolutionary patterns were described in our previous works independently of each other. In this work we have developed a single model which allows us to reproduce the principal patterns in Darwin's diagram. Some more complex evolutionary patterns are also observed. The relation between Darwin's definition of species, stated above, and Mayr's definition of species (group of individuals that can reproduce) is also discussed.

Practitioners' Perspectives on Cultural Sensitivity in Latina/o Teen Pregnancy Prevention

ERIC Educational Resources Information Center

Wilkinson-Lee, Ada M.; Russell, Stephen T.; Lee, Faye C. H.

2006-01-01

This study examined practitioners' understandings of cultural sensitivity in the context of pregnancy prevention programs for Latina teens. Fifty-eight practitioners from teen pregnancy prevention programs in California were interviewed in a guided conversation format. Three themes emerged in our analysis. First, practitioners' definitions of…

42 CFR 54.2 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-10-01

... TO STATES RECEIVING SUBSTANCE ABUSE PREVENTION AND TREATMENT BLOCK GRANTS AND/OR PROJECTS FOR... programs authorized under: (1) The Substance Abuse Prevention and Treatment (SAPT) Block Grant, 42 U.S.C... Grants, 42 U.S.C. 290cc-21 to 290cc-35 insofar as they fund substance abuse prevention and/or treatment...

42 CFR 54.2 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-10-01

... TO STATES RECEIVING SUBSTANCE ABUSE PREVENTION AND TREATMENT BLOCK GRANTS AND/OR PROJECTS FOR... programs authorized under: (1) The Substance Abuse Prevention and Treatment (SAPT) Block Grant, 42 U.S.C... Grants, 42 U.S.C. 290cc-21 to 290cc-35 insofar as they fund substance abuse prevention and/or treatment...

42 CFR 54.2 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-10-01

... TO STATES RECEIVING SUBSTANCE ABUSE PREVENTION AND TREATMENT BLOCK GRANTS AND/OR PROJECTS FOR... programs authorized under: (1) The Substance Abuse Prevention and Treatment (SAPT) Block Grant, 42 U.S.C... Grants, 42 U.S.C. 290cc-21 to 290cc-35 insofar as they fund substance abuse prevention and/or treatment...

42 CFR 54.2 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-10-01

... TO STATES RECEIVING SUBSTANCE ABUSE PREVENTION AND TREATMENT BLOCK GRANTS AND/OR PROJECTS FOR... programs authorized under: (1) The Substance Abuse Prevention and Treatment (SAPT) Block Grant, 42 U.S.C... Grants, 42 U.S.C. 290cc-21 to 290cc-35 insofar as they fund substance abuse prevention and/or treatment...

42 CFR 54.2 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-10-01

... TO STATES RECEIVING SUBSTANCE ABUSE PREVENTION AND TREATMENT BLOCK GRANTS AND/OR PROJECTS FOR... programs authorized under: (1) The Substance Abuse Prevention and Treatment (SAPT) Block Grant, 42 U.S.C... Grants, 42 U.S.C. 290cc-21 to 290cc-35 insofar as they fund substance abuse prevention and/or treatment...

40 CFR 112.3 - Requirement to prepare and implement a Spill Prevention, Control, and Countermeasure Plan.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 22 2011-07-01 2011-07-01 false Requirement to prepare and implement a Spill Prevention, Control, and Countermeasure Plan. 112.3 Section 112.3 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS OIL POLLUTION PREVENTION Applicability, Definitions...

40 CFR 112.3 - Requirement to prepare and implement a Spill Prevention, Control, and Countermeasure Plan.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 23 2012-07-01 2012-07-01 false Requirement to prepare and implement a Spill Prevention, Control, and Countermeasure Plan. 112.3 Section 112.3 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS OIL POLLUTION PREVENTION Applicability, Definitions...

40 CFR 112.4 - Amendment of Spill Prevention, Control, and Countermeasure Plan by Regional Administrator.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 23 2012-07-01 2012-07-01 false Amendment of Spill Prevention, Control, and Countermeasure Plan by Regional Administrator. 112.4 Section 112.4 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS OIL POLLUTION PREVENTION Applicability, Definitions...

An Old-Growth Definition for Western Juniper Woodlands: Texas Ashe Juniper Dominated or Codominated Communities

Treesearch

David D. Diamond

1997-01-01

Old growth is widely acknowledged today as an essential part of managed forests, particularly on public lands. However, this concept is relatively new, evolving since the 1970's when a grassroots movement in the Pacific Northwest began in earnest to define old growth. In response to changes in public attitude, the U.S. Department of Agriculture, Forest Service,...

Evolving African Attitudes to European Education: Resistance, Pervert Effects of the Single System Paradox, and the "Ubuntu" Framework for Renewal

ERIC Educational Resources Information Center

Assié-Lumumba, N'Dri Thérèse

2016-01-01

This paper is a reflection that critically examines the dynamics of education and the struggle by African people for freedom, control of the mind, self-definition and the right to determine their own destiny from the start of colonial rule to the present. The primary methodological approach is historical structuralism, which stipulates that social…

Symposium on Current Research in the Chemical Sciences: Third Annual Southern Station Chemical Sciences Meeting

Treesearch

Timothy G. Rials; [Editor

1994-01-01

The original charter for this annual meeting of chemical sciences personnel called for an informal atmosphere for the discussion of common concerns and needs. The years have seen the definition of our "common concern" evolve into a sharing of our efforts in applying the science of chemistry to the resolution of problems faced by our forest resource. I believe...

From ABCs to DVDs: Profiles of Infants' Home Media Environments in the First Two Years of Life

ERIC Educational Resources Information Center

Mol, Suzanne E.; Neuman, Susan B.; Strouse, Gabrielle A.

2014-01-01

The very definition of print exposure has evolved in recent years as has the production of new media for infants and toddlers. Recognising that parents now have a confluence of media to select from, our study was designed to provide a richer understanding of home-literacy environments among 100 infants. Three profiles of families' home media…

Henry Ford Health Systems

Cancer.gov

Henry Ford Health Systems evolved from a hospital into a system delivering care to 2.5 million patients and includes the Cancer Epidemiology, Prevention and Control Program, which focuses on epidemiologic and public health aspects of cancer.

Revisiting the refeeding syndrome: Results of a systematic review.

PubMed

Friedli, Natalie; Stanga, Zeno; Sobotka, Lubos; Culkin, Alison; Kondrup, Jens; Laviano, Alessandro; Mueller, Beat; Schuetz, Philipp

2017-03-01

Although described >70 y ago, the refeeding syndrome (RFS) remains understudied with lack of standardized definition and treatment recommendations. The aim of this systematic review was to gather evidence regarding standardized definition, incidence rate and time course of occurrence, association with adverse clinical outcomes, risk factors, and therapeutic strategies to prevent or treat this condition. We searched MEDLINE and EMBASE for interventional and observational clinical trials focusing on RFS, excluding case reports and reviews. We extracted data based on a predefined case report form and assessed bias. Of 2207 potential abstracts, 45 records with a total of 6608 patients were included (3 interventional trials, 16 studies focusing on anorexic patients). Definitions for RFS were highly heterogenous with most studies relying on blood electrolyte disturbances only and others also including clinical symptoms. Incidence rates varied between 0% and 80%, depending on the definition and patient population studied. Occurrence was mostly within the first 72 h of start of nutritional therapy. Most of the risk factors were in accordance with National Institute for Health and Care Excellence guidelines, with older age and enteral feeding being additional factors. There was no strong evidence regarding association of RFS and adverse outcomes, as well as regarding preventive measures and treatment algorithms. This systematic review focusing on RFS found consensus regarding risk factors and timing of occurrence, but wide variations regarding definition, reported incidence rates, preventive measures and treatment recommendations. Further research to fill this gap is urgently needed. Copyright © 2016 Elsevier Inc. All rights reserved.

Social Maladjustment: Definition, Identification, and Programing.

ERIC Educational Resources Information Center

Center, David B.

1989-01-01

This paper argues for a broad interpretation of the definition of social maladjustment; presents a hypothetical model of the relationship between adequacy of parenting and adequacy of environment; discusses methods for identifying social maladjustment; and describes programing for prevention and rehabilitation through development of social…

40 CFR 745.323 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 32 2012-07-01 2012-07-01 false Definitions. 745.323 Section 745.323 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT LEAD-BASED PAINT POISONING PREVENTION IN CERTAIN RESIDENTIAL STRUCTURES State and Indian Tribal Programs § 745.323...

40 CFR 745.323 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 31 2011-07-01 2011-07-01 false Definitions. 745.323 Section 745.323 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT LEAD-BASED PAINT POISONING PREVENTION IN CERTAIN RESIDENTIAL STRUCTURES State and Indian Tribal Programs § 745.323...

40 CFR 745.323 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 32 2013-07-01 2013-07-01 false Definitions. 745.323 Section 745.323 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT LEAD-BASED PAINT POISONING PREVENTION IN CERTAIN RESIDENTIAL STRUCTURES State and Indian Tribal Programs § 745.323...

40 CFR 745.323 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Definitions. 745.323 Section 745.323 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT LEAD-BASED PAINT POISONING PREVENTION IN CERTAIN RESIDENTIAL STRUCTURES State and Indian Tribal Programs § 745.323...

40 CFR 745.323 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 31 2014-07-01 2014-07-01 false Definitions. 745.323 Section 745.323 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT LEAD-BASED PAINT POISONING PREVENTION IN CERTAIN RESIDENTIAL STRUCTURES State and Indian Tribal Programs § 745.323...

Model or Myopia? Exploiting Water Markets to Address Population and Drought Risks in a Changing World

NASA Astrophysics Data System (ADS)

Reed, P. M.

2012-12-01

Climate change, population demands, and evolving land-use represent strong risks to the sustainable development and stability of world-wide urban water supplies. There is a growing consensus that non-structural supply management instruments such as water markets have significant potential to reduce the risks and vulnerabilities in complex urban water systems. This paper asks a common question, what are the tradeoffs for a city using water market supply instruments?. This question emerges quickly in policy and management, but its answer is deceptively difficult to attain using traditional planning tools and management frameworks. This research demonstrates new frameworks that facilitate rapid evaluation of hypotheses on the reliability, resiliency, adaptability, and cost-effectiveness of urban water supply systems. This study considers a broader exploration of the issues of "nonstationarity" and "uncertainty" in urban water planning. As we invest in new information and prediction frameworks for the coupled human-natural systems that define our water, our problem definitions (i.e., objectives, constraints, preferences, and hypotheses) themselves evolve. From a formal mathematical perspective, this means that our management problems are structurally uncertain and nonstationary (i.e., the definition of optimality changes across regions, times, and stakeholders). This uncertainty and nonstationarity in our problem definitions needs to be more explicitly acknowledged in adaptive management and integrated water resources management. This study demonstrates the potential benefits of exploring these issues in the context of a city in the Lower Rio Grande Valley (LRGV) of Texas, USA determining how to use its regional water market to manage population and drought risks.

Public Sensitization as a Tool for Preventing Domestic Violence against Women in Nsukka Education Zone, Enugu State, Nigeria

ERIC Educational Resources Information Center

Oyeoku, E. K.; Meziobi, D.; Ezegbe, N. B.; Obikwelu, C. L.

2013-01-01

The main purpose of the study was to evolve modalities for preventing domestic violence against women in Nsukka education zone. Three research questions and two null hypotheses guided the study. The sample comprised 150 urban women and 450 rural women in Nsukka education zone. A 20-item questionnaire was developed, validated, and administered to…

Economic contract theory tests models of mutualism.

PubMed

Weyl, E Glen; Frederickson, Megan E; Yu, Douglas W; Pierce, Naomi E

2010-09-07

Although mutualisms are common in all ecological communities and have played key roles in the diversification of life, our current understanding of the evolution of cooperation applies mostly to social behavior within a species. A central question is whether mutualisms persist because hosts have evolved costly punishment of cheaters. Here, we use the economic theory of employment contracts to formulate and distinguish between two mechanisms that have been proposed to prevent cheating in host-symbiont mutualisms, partner fidelity feedback (PFF) and host sanctions (HS). Under PFF, positive feedback between host fitness and symbiont fitness is sufficient to prevent cheating; in contrast, HS posits the necessity of costly punishment to maintain mutualism. A coevolutionary model of mutualism finds that HS are unlikely to evolve de novo, and published data on legume-rhizobia and yucca-moth mutualisms are consistent with PFF and not with HS. Thus, in systems considered to be textbook cases of HS, we find poor support for the theory that hosts have evolved to punish cheating symbionts; instead, we show that even horizontally transmitted mutualisms can be stabilized via PFF. PFF theory may place previously underappreciated constraints on the evolution of mutualism and explain why punishment is far from ubiquitous in nature.

Economic contract theory tests models of mutualism

PubMed Central

Weyl, E. Glen; Frederickson, Megan E.; Yu, Douglas W.; Pierce, Naomi E.

2010-01-01

Although mutualisms are common in all ecological communities and have played key roles in the diversification of life, our current understanding of the evolution of cooperation applies mostly to social behavior within a species. A central question is whether mutualisms persist because hosts have evolved costly punishment of cheaters. Here, we use the economic theory of employment contracts to formulate and distinguish between two mechanisms that have been proposed to prevent cheating in host–symbiont mutualisms, partner fidelity feedback (PFF) and host sanctions (HS). Under PFF, positive feedback between host fitness and symbiont fitness is sufficient to prevent cheating; in contrast, HS posits the necessity of costly punishment to maintain mutualism. A coevolutionary model of mutualism finds that HS are unlikely to evolve de novo, and published data on legume–rhizobia and yucca–moth mutualisms are consistent with PFF and not with HS. Thus, in systems considered to be textbook cases of HS, we find poor support for the theory that hosts have evolved to punish cheating symbionts; instead, we show that even horizontally transmitted mutualisms can be stabilized via PFF. PFF theory may place previously underappreciated constraints on the evolution of mutualism and explain why punishment is far from ubiquitous in nature. PMID:20733067

Zinc supplementation for the prevention of acute lower respiratory infection in children in developing countries: meta-analysis and meta-regression of randomized trials.

PubMed

Roth, Daniel E; Richard, Stephanie A; Black, Robert E

2010-06-01

Routine zinc supplementation is a potential intervention for the prevention of acute lower respiratory infection (ALRI) in developing countries. However, discrepant findings from recent randomized trials remain unexplained. Randomized trials of zinc supplementation in young children in developing countries were identified by a systematic literature review. Trials included in the meta-analysis met specific criteria, including participants <5 years of age, daily/weekly zinc and control supplementation for greater than 3 months, active household surveillance for respiratory morbidity and use of a case definition that included at least one sign of lower respiratory tract illness. ALRI case definitions were classified on the basis of specificity/severity. Incidence rate ratios (IRRs) were pooled by random-effects models. Meta-regression and sub-group analysis were performed to assess potential sources of between-study heterogeneity. Ten trials were eligible for inclusion (n = 49 450 children randomized). Zinc reduced the incidence of ALRI defined by specific clinical criteria [IRR 0.65, 95% confidence interval (CI) 0.52-0.82], but had no effect on lower-specificity ALRI case definitions based on caregiver report (IRR 1.01, 95% CI 0.91-1.12) or World Health Organization 'non-severe pneumonia' (0.96, 95% CI 0.86-1.08). By meta-regression, the effect of zinc was associated with ALRI case definition, but not with mean baseline age, geographic location, nutritional status or zinc dose. Routine zinc supplementation reduced the incidence of childhood ALRI defined by relatively specific clinical criteria, but the effect was null if lower specificity case definitions were applied. The choice of ALRI case definition may substantially influence inferences from community trials regarding the efficacy of preventive interventions.

Contraceptive Choice and Use of Dual Protection Among Women Living with HIV in Canada: Priorities for Integrated Care.

PubMed

Kaida, Angela; Patterson, Sophie; Carter, Allison; Loutfy, Mona; Ding, Erin; Sereda, Paul; Webster, Kath; Pick, Neora; Kestler, Mary; de Pokomandy, Alexandra

2017-12-01

Preventing unintended pregnancy and HIV transmission is important for women with HIV, but little is known about their contraceptive use, particularly under current antiretroviral therapy (ART) recommendations for treatment and prevention. The prevalence of contraceptive use and of dual protection was examined among 453 sexually active women with HIV aged 16-49 and enrolled in the Canadian HIV Women's Sexual and Reproductive Health Cohort Study in 2013-2015; multivariable logistic regression was used to identify correlates of use. Two definitions of dual protection were assessed: the World Health Organization (WHO) definition (consistent condom use alongside another effective method) and an expanded definition (consistent condom use or a suppressed HIV viral load alongside an effective method). Overall, 73% of women used effective contraceptives, primarily male condoms (45%) or tubal ligation (19%). Eighteen percent practiced WHO-defined dual protection, and 40% practiced dual protection according to the expanded definition. Characteristics positively associated with contraceptive use were younger age, having been pregnant, being heterosexual, being unaware of ART's HIV prevention benefits and having had partners of unknown HIV status (odds ratios, 1.1-6.7). Younger age and perceived inability to become pregnant were positively associated with both definitions of dual protection (1.04-3.3); additionally, WHO-defined dual protection was associated with perceiving HIV care to be women-centered and having had partners of unknown HIV status (2.0-4.1), and dual protection under the expanded definition was related to having been pregnant (2.7). Future research should explore how sustained ART and broader contraceptive options can support women's sexual and reproductive health care needs. Copyright © 2017 by the Guttmacher Institute.

Trauma patients meeting both Centers for Disease Control and Prevention's definitions for ventilator-associated pneumonia had worse outcomes than those meeting only one.

PubMed

Younan, Duraid; Griffin, Russell; Swain, Thomas; Pittet, Jean-Francois; Camins, Bernard

2017-08-01

The Centers for Disease Control and Prevention's National Healthcare Safety Network (NHSN) replaced its old definition for ventilator-associated pneumonia (VAP) with the ventilator-associated events algorithm in 2013. We sought to compare the outcome of trauma patients meeting the definitions for VAP in the two modules. Trauma patients with blunt or penetrating injuries and with at least 2 d of ventilator support were identified from the trauma registry from 2013 to 2014. VAP was determined using two methods: (1) VAP as defined by the "old," clinically based NHSN definition and (2) possible VAP as defined by the updated "new" NHSN definition. Cohen's kappa statistic was determined to compare the two definitions for VAP. To compare demographic and clinical outcomes, the chi-square and Student's t-tests were used for categorical and continuous variables, respectively. From 2013 to 2014, there were 1165 trauma patients admitted who had at least 2 d of ventilator support. Seventy-eight patients (6.6%) met the "new" NHSN definition for possible VAP, 361 patients (30.9%) met the "old" definition of VAP, and 68 patients (5.8%) met both definitions. The kappa statistic between VAP as defined by the "new" and "old" definitions was 0.22 (95% confidence interval, 0.17-0.27). There were no differences in age, gender, race, or injury severity score when comparing patients who met the different definitions. Those satisfying both definitions had longer ventilator support days (P = 0.0009), intensive care unit length of stay (LOS; P = 0.0003), and hospital LOS (P = 0.0344) when compared with those meeting only one definition. There was no difference in mortality for those meeting both and those meeting the old definition for VAP; patients meeting both definitions had higher respiratory rate at arrival (P = 0.0178). There was no difference in mortality between patients meeting the "old" and "new" NHSN definitions for VAP; those who met "both" definitions had longer ventilator support days, intensive care unit, and hospital LOS. Copyright © 2017 Elsevier Inc. All rights reserved.

Health literacy and public health: a systematic review and integration of definitions and models.

PubMed

Sørensen, Kristine; Van den Broucke, Stephan; Fullam, James; Doyle, Gerardine; Pelikan, Jürgen; Slonska, Zofia; Brand, Helmut

2012-01-25

Health literacy concerns the knowledge and competences of persons to meet the complex demands of health in modern society. Although its importance is increasingly recognised, there is no consensus about the definition of health literacy or about its conceptual dimensions, which limits the possibilities for measurement and comparison. The aim of the study is to review definitions and models on health literacy to develop an integrated definition and conceptual model capturing the most comprehensive evidence-based dimensions of health literacy. A systematic literature review was performed to identify definitions and conceptual frameworks of health literacy. A content analysis of the definitions and conceptual frameworks was carried out to identify the central dimensions of health literacy and develop an integrated model. The review resulted in 17 definitions of health literacy and 12 conceptual models. Based on the content analysis, an integrative conceptual model was developed containing 12 dimensions referring to the knowledge, motivation and competencies of accessing, understanding, appraising and applying health-related information within the healthcare, disease prevention and health promotion setting, respectively. Based upon this review, a model is proposed integrating medical and public health views of health literacy. The model can serve as a basis for developing health literacy enhancing interventions and provide a conceptual basis for the development and validation of measurement tools, capturing the different dimensions of health literacy within the healthcare, disease prevention and health promotion settings.

Definitions of histocompatibility typing terms.

PubMed

Nunes, Eduardo; Heslop, Helen; Fernandez-Vina, Marcelo; Taves, Cynthia; Wagenknecht, Dawn R; Eisenbrey, A Bradley; Fischer, Gottfried; Poulton, Kay; Wacker, Kara; Hurley, Carolyn Katovich; Noreen, Harriet; Sacchi, Nicoletta

2011-12-01

Histocompatibility testing for stem cell and solid organ transplantation has become increasingly complex as newly discovered HLA alleles are described. HLA typing assignments reported by laboratories are used by physicians and donor registries for matching donors and recipients. To communicate effectively, a common language for histocompatibility terms should be established. In early 2010, representatives from Clinical, Registry, and Histocompatibility organizations joined together as the Harmonization of Histocompatibility Typing Terms Working Group to define a consensual language for laboratories, physicians, and registries to communicate histocompatibility typing information. The Working Group defined terms for HLA typing resolution, HLA matching, and a format for reporting HLA assignments. In addition, definitions of verification typing and extended typing were addressed. The original draft of the Definitions of Histocompatibility Typing Terms was disseminated to colleagues from each organization to gain feedback and create a collaborative document. Commentary gathered during this 90-day review period were discussed and implemented for preparation of this report. Histocompatibility testing continues to evolve; thus, the definitions agreed on today probably will require refinement and perhaps additional terminology in the future.

A current perspective on medical informatics and health sciences librarianship

PubMed Central

Perry, Gerald J.; Roderer, Nancy K.; Assar, Soraya

2005-01-01

Objective: The article offers a current perspective on medical informatics and health sciences librarianship. Narrative: The authors: (1) discuss how definitions of medical informatics have changed in relation to health sciences librarianship and the broader domain of information science; (2) compare the missions of health sciences librarianship and health sciences informatics, reviewing the characteristics of both disciplines; (3) propose a new definition of health sciences informatics; (4) consider the research agendas of both disciplines and the possibility that they have merged; and (5) conclude with some comments about actions and roles for health sciences librarians to flourish in the biomedical information environment of today and tomorrow. Summary: Boundaries are disappearing between the sources and types of and uses for health information managed by informaticians and librarians. Definitions of the professional domains of each have been impacted by these changes in information. Evolving definitions reflect the increasingly overlapping research agendas of both disciplines. Professionals in these disciplines are increasingly functioning collaboratively as “boundary spanners,” incorporating human factors that unite technology with health care delivery. PMID:15858622

A proposed lexicon of terms and concepts for human-bear management in North America

USGS Publications Warehouse

Hopkins, John B.; Herrero, Stephen; Shideler, Richard T.; Gunther, Kerry A.; Schwartz, Charles C.; Kalinowski, Steven T.

2010-01-01

We believe that communication within and among agency personnel in the United States and Canada about the successes and failures of their human–bear (Ursidae) management programs will increase the effectiveness of these programs and of bear research. To communicate more effectively, we suggest agencies clearly define terms and concepts used in human–bear management and use them in a consistent manner. We constructed a human–bear management lexicon of terms and concepts using a modified Delphi method to provide a resource that facilitates more effective communication among human–bear management agencies. Specifically, we defined 40 terms and concepts in human–bear management and suggest definitions based on discussions with 13 other professionals from the United States and Canada. Although new terms and concepts will emerge in the future and definitions will evolve as we learn more about bear behavior and ecology, our purpose is to suggest working definitions for terms and concepts to help guide human–bear management and research activities in North America. Applications or revisions of these definitions may be useful outside of North America.

24 CFR 35.86 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-04-01

... Housing and Urban Development Office of the Secretary, Department of Housing and Urban Development LEAD-BASED PAINT POISONING PREVENTION IN CERTAIN RESIDENTIAL STRUCTURES Disclosure of Known Lead-Based Paint and/or Lead-Based Paint Hazards Upon Sale or Lease of Residential Property § 35.86 Definitions. The...

24 CFR 35.86 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-04-01

... Housing and Urban Development Office of the Secretary, Department of Housing and Urban Development LEAD-BASED PAINT POISONING PREVENTION IN CERTAIN RESIDENTIAL STRUCTURES Disclosure of Known Lead-Based Paint and/or Lead-Based Paint Hazards Upon Sale or Lease of Residential Property § 35.86 Definitions. The...

24 CFR 35.86 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-04-01

... Housing and Urban Development Office of the Secretary, Department of Housing and Urban Development LEAD-BASED PAINT POISONING PREVENTION IN CERTAIN RESIDENTIAL STRUCTURES Disclosure of Known Lead-Based Paint and/or Lead-Based Paint Hazards Upon Sale or Lease of Residential Property § 35.86 Definitions. The...

45 CFR 31.2 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-10-01

... limited to, the Administration for Children and Families, Administration on Aging, the Centers for Disease Control and Prevention, the Centers for Medicare & Medicaid Services, the Food and Drug Administration... 45 Public Welfare 1 2012-10-01 2012-10-01 false Definitions. 31.2 Section 31.2 Public Welfare...

45 CFR 31.2 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-10-01

... limited to, the Administration for Children and Families, Administration on Aging, the Centers for Disease Control and Prevention, the Centers for Medicare & Medicaid Services, the Food and Drug Administration... 45 Public Welfare 1 2011-10-01 2011-10-01 false Definitions. 31.2 Section 31.2 Public Welfare...

45 CFR 31.2 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-10-01

... limited to, the Administration for Children and Families, Administration on Aging, the Centers for Disease Control and Prevention, the Centers for Medicare & Medicaid Services, the Food and Drug Administration... 45 Public Welfare 1 2013-10-01 2013-10-01 false Definitions. 31.2 Section 31.2 Public Welfare...

45 CFR 31.2 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-10-01

... limited to, the Administration for Children and Families, Administration on Aging, the Centers for Disease Control and Prevention, the Centers for Medicare & Medicaid Services, the Food and Drug Administration... 45 Public Welfare 1 2010-10-01 2010-10-01 false Definitions. 31.2 Section 31.2 Public Welfare...

45 CFR 31.2 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-10-01

... limited to, the Administration for Children and Families, Administration on Aging, the Centers for Disease Control and Prevention, the Centers for Medicare & Medicaid Services, the Food and Drug Administration... 45 Public Welfare 1 2014-10-01 2014-10-01 false Definitions. 31.2 Section 31.2 Public Welfare...

Potential Misclassification of Urinary Tract-Related Bacteremia Upon Applying the 2015 Catheter-Associated Urinary Tract Infection Surveillance Definition From the National Healthcare Safety Network.

PubMed

Greene, M Todd; Ratz, David; Meddings, Jennifer; Fakih, Mohamad G; Saint, Sanjay

2016-04-01

The Centers for Disease Control and Prevention recently updated the surveillance definition of catheter-associated urinary tract infection to include only urine culture bacteria of at least 1 × 10(5) colony-forming units/mL. Our findings suggest that the new surveillance definition may fail to capture clinically meaningful catheter-associated urinary tract infections.

Prevention of Child Maltreatment: The Use of Social Support Systems.

ERIC Educational Resources Information Center

Anderson, Dale Robert

A review of the clinically relevant literature on prevention of child maltreatment was conducted in an attempt to provide: (1) a definition and theoretical understanding of some aspects of prevention, child maltreatment, and social support systems; (2) a proposal of the usefulness of social isolation as an important theme in interpreting the…

Primary Prevention: Reducing Institutional Racism/Sexism Through Consultation. Case Study.

ERIC Educational Resources Information Center

O'Neil, James M.; Conyne, Robert

This paper presents a two-year primary prevention intervention aimed at reducing institutional racism and sexism at a large midwestern university. A case study format is used to describe the history, process, and outcomes of the consultation that resulted in proactive change in the institution. Definitions of primary prevention are given and the…

[Secondary and tertiary prevention of allergic asthma in children].

PubMed

Rancé, F; Deschildre, A; Bidat, E; Just, J; Couderc, L; Wanin, S; Weiss, L

2010-12-01

Asthma is a disease of the lung epithelial barrier, most often associated with allergy in children. Asthma and allergy are two distinct diseases, but the phenotypic expression of asthma depends on atopic status. A better definition of phenotypes of asthma would result in better targeting of prevention and treatment modalities. Secondary prevention aims to prevent the onset of asthma and the acquisition of new sensitizations in sensitized children. Studies concerning allergen avoidance are insufficient to reach a definitive conclusion and antihistamines have not been shown to be effective. The results for specific immunotherapy suggest a benefit to prevent transition from allergic rhinitis to asthma and the onset of new sensitizations. Tertiary prevention aims to reduce symptoms in children with an existing allergic asthma diagnosis. The avoidance of known respiratory allergens will only be effective in combination with management of the whole environment. Specific immunotherapy has a real place, in combination with background therapy. It should be used according to guidelines in appropriately treated patients. Copyright © 2010 SPLF. Published by Elsevier Masson SAS. All rights reserved.

Defining refractory migraine: results of the RHSIS Survey of American Headache Society members.

PubMed

Schulman, Elliott A; Peterlin, B Lee; Lake, Alvin E; Lipton, Richard B; Hanlon, Alexandra; Siegel, Sherry; Levin, Morris; Goadsby, Peter J; Markley, Herbert G

2009-04-01

To gauge consensus regarding a proposed definition for refractory migraine proposed by Refractory Headache Special Interest Section, and where its use would be most appropriate. Headache experts have long recognized that a subgroup of headache sufferers remains refractory to treatment. Although different groups have proposed criteria to define refractory migraine, the definition remains controversial. The Refractory Headache Special Interest Section of the American Headache Society developed a definition through a consensus process, assisted by a literature review and initial membership survey. A 12-item questionnaire was distributed at the American Headache Society meeting in 2007 during a platform session and at the Refractory Headache Special Interest Section symposium. The same questionnaire was subsequently sent to all American Headache Society members via e-mail. A total of 151 responses from AHS members form the basis of this report. The survey instrument was designed using Survey Monkey. Frequencies and percentages of the survey were used to describe survey responses. American Headache Society members agreed that a definition for refractory migraine is needed (91%) that it should be added to the International Classification of Headache Disorders-2 (86%), and that refractory forms of non-migraine headache disorders should be defined (87%). Responders believed a refractory migraine definition would be of greatest value in selecting patients for clinical drug trials. The current refractory migraine definition requires a diagnosis of migraine, interference with function or quality of life despite modification of lifestyle factors, and adequate trials of acute and preventive medicines with established efficacy. The proposed criteria for the refractory migraine definition require failing 2 preventive medications to meet the threshold for failure. Although 42% of respondents agreed with the working definition of refractory migraine, 43% favored increasing the number to 3 (50%) or 4 (26%) preventive treatment failures. When respondents were asked if they felt that the proposed definition was appropriate to select patients for invasive procedures (patent foramen ovale repair or stimulators) only 44% agreed. There is a consensus for a need for a definition for refractory migraine and that it should be added to the International Classification of Headache Disorder-2. There was also general agreement by the responders that refractory forms of non-migraine headache disorders should be defined.

Using Books to Prevent and Treat Adolescent Chemical Dependency.

ERIC Educational Resources Information Center

Pardeck, John T.

1991-01-01

Presents strategies for using bibliotherapeutic process to prevent and treat adolescent alcohol and drug abuse. Definitions, goals, and principles of bibliotherapy are overviewed. Synopses of several useful books that focus on chemical dependency are presented. (Author)

Occurrence of pregnancy and pregnancy outcomes during isotretinoin therapy.

PubMed

Henry, David; Dormuth, Colin; Winquist, Brandace; Carney, Greg; Bugden, Shawn; Teare, Gary; Lévesque, Linda E; Bérard, Anick; Paterson, J Michael; Platt, Robert W

2016-07-12

Isotretinoin, a teratogen, is widely used to treat cystic acne. Although the risks of pregnancy during isotretinoin therapy are well recognized, there are doubts about the level of adherence with the pregnancy prevention program in Canada. Our objective was to evaluate the effectiveness of the Canadian pregnancy prevention program in 4 provinces: British Columbia, Saskatchewan, Manitoba and Ontario. Using administrative data, we identified 4 historical cohorts of female users of isotretinoin (aged 12-48 yr) for the period 1996 to 2011. We defined pregnancy using International Statistical Classification of Diseases and billing codes. One definition included only cases with documented pregnancy outcomes (high-specificity definition); the other definition also included individuals recorded as receiving prenatal care (high-sensitivity definition). We studied new courses of isotretinoin and detected pregnancies in 2 time windows: during isotretinoin treatment only and up to 42 weeks after treatment. Live births were followed for 1 year to identify congenital malformations. A total of 59 271 female patients received 102 308 courses of isotretinoin. Between 24.3% and 32.9% of participants received prescriptions for oral contraceptives while they were taking isotretinoin, compared with 28.3% to 35.9% in the 12 months before isotretinoin was started. According to the high-specificity definition of pregnancy, there were 186 pregnancies during isotretinoin treatment (3.1/1000 isotretinoin users), compared with 367 (6.2/1000 users) according to the high-sensitivity definition. By 42 weeks after treatment, there were 1473 pregnancies (24.9/1000 users), according to the high-specificity definition. Of these, 1331 (90.4%) terminated spontaneously or were terminated by medical intervention. Among the 118 live births were 11 (9.3%) cases of congenital malformation. Pregnancy rates during isotretinoin treatment remained constant between 1996 and 2011. Adherence to the isotretinoin pregnancy prevention program in Canada was poor during the 15-year period of this study. © 2016 Canadian Medical Association or its licensors.

Occurrence of pregnancy and pregnancy outcomes during isotretinoin therapy

PubMed Central

Henry, David; Dormuth, Colin; Winquist, Brandace; Carney, Greg; Bugden, Shawn; Teare, Gary; Lévesque, Linda E.; Bérard, Anick; Paterson, J. Michael; Platt, Robert W.

2016-01-01

Background: Isotretinoin, a teratogen, is widely used to treat cystic acne. Although the risks of pregnancy during isotretinoin therapy are well recognized, there are doubts about the level of adherence with the pregnancy prevention program in Canada. Our objective was to evaluate the effectiveness of the Canadian pregnancy prevention program in 4 provinces: British Columbia, Saskatchewan, Manitoba and Ontario. Methods: Using administrative data, we identified 4 historical cohorts of female users of isotretinoin (aged 12–48 yr) for the period 1996 to 2011. We defined pregnancy using International Statistical Classification of Diseases and billing codes. One definition included only cases with documented pregnancy outcomes (high-specificity definition); the other definition also included individuals recorded as receiving prenatal care (high-sensitivity definition). We studied new courses of isotretinoin and detected pregnancies in 2 time windows: during isotretinoin treatment only and up to 42 weeks after treatment. Live births were followed for 1 year to identify congenital malformations. Results: A total of 59 271 female patients received 102 308 courses of isotretinoin. Between 24.3% and 32.9% of participants received prescriptions for oral contraceptives while they were taking isotretinoin, compared with 28.3% to 35.9% in the 12 months before isotretinoin was started. According to the high-specificity definition of pregnancy, there were 186 pregnancies during isotretinoin treatment (3.1/1000 isotretinoin users), compared with 367 (6.2/1000 users) according to the high-sensitivity definition. By 42 weeks after treatment, there were 1473 pregnancies (24.9/1000 users), according to the high-specificity definition. Of these, 1331 (90.4%) terminated spontaneously or were terminated by medical intervention. Among the 118 live births were 11 (9.3%) cases of congenital malformation. Pregnancy rates during isotretinoin treatment remained constant between 1996 and 2011. Interpretation: Adherence to the isotretinoin pregnancy prevention program in Canada was poor during the 15-year period of this study. PMID:27114489

Do We Need to Understand the Technology to Get to the Science? A Systematic Review of the Concept of Computer Literacy in Preventive Health Programs

ERIC Educational Resources Information Center

Dominick, Gregory M.; Friedman, Daniela B.; Hoffman-Goetz, Laurie

2009-01-01

Objective: To systematically review definitions and descriptions of computer literacy as related to preventive health education programs. Method: A systematic review of the concept of computer literacy as related to preventive health education was conducted. Empirical studies published between 1994 and 2007 on prevention education programs with a…

The evolving role of data scientist during 20 years of the British Atmospheric Data Centre (Invited)

NASA Astrophysics Data System (ADS)

Pascoe, S.; Parton, G.; Pascoe, C.; Guillory, A.; da Costa, E. D.

2013-12-01

In 2014 The British Atmospheric Data Centre (BADC), now part of the Centre of Environmental Data Archival (CEDA), will celebrate its 20th anniversary. During its lifetime, most BADC staff have defined themselves as data scientists by virtue of being scientists by background and "data workers" by practice. However, the definition of data scientist has been ill defined until recently. As the term has become popularised in the world of business and general information technology, we ask ourselves to what extent the popular definition fits our profession. We observe that data science, as practised at CEDA, encompasses several roles which overlap and compliment each other as we strive to be enablers of data exploitation. For us a data scientist's skills include elements of data curation, software engineering, data infrastructure management and data-intensive research. As data science has evolved the balance between these roles has shifted in response to changes in technology, demands of the research community and funding drivers. We have had to balance our role as enablers of data exploitation, by providing services and infrastructure to the geo-science community, with our role as pioneers of data exploitation itself. By telling the story of how these roles have evolved during the 20 year history of the BADC, we aim to explore the maturing role of data scientist as practised within the geo-sciences and contrast that role with its recently popularised usage. Looking forward we will address questions about how centres of expertise, such as CEDA, can best increase the data capabilities of geo-science research as a whole in order to facilitate the transition to data-intensive science.

A Systems Approach to Lower Cost Missions: Following the Rideshare Paradigm

NASA Technical Reports Server (NTRS)

Herrell, L.

2009-01-01

Small-satellite rideshare capabilities and opportunities for low-cost access to space have been evolving over the past 10 years. Small space launch vehicle technology is rapidly being developed and demonstrated, including the Minotaur series and the Space X Falcon, among others, along with the lower cost launch facilities at Alaska's Kodiak Launch Complex, NASA's Wallops Flight Facility, and the Reagan Test Site in the Pacific. Demonstrated capabilities for the launch of multiple payloads have increased (and continue to increase) significantly. This will allow more efficient and cost-effective use of the various launch opportunities, including utilizing the excess capacity of the emerging Evolved Expendable Launch Vehicle (EELV)-based missions. The definition of standardized interfaces and processes, along with various user guides and payload implementation plans, has been developed and continues to be refined. Top-level agency policies for the support of low-cost access to space for small experimental payloads, such as the DoD policy structure on auxiliary payloads, have been defined and provide the basis for the continued refinement and implementation of these evolving technologies. Most importantly, the coordination and cooperative interfaces between the various stakeholders continues to evolve. The degree of this coordination and technical interchange is demonstrated by the wide stakeholder participation at the recent 2008 Small Payload Rideshare Workshop, held at NASA's Wallops Flight Facility. This annual workshop has been the major platform for coordination and technical interchange within the rideshare community and with the various sponsoring agencies. These developments have provided the foundation for a robust low-cost small payload rideshare capability. However, the continued evolution, sustainment, and utilization of these capabilities will require continued stakeholder recognition, support, and nourishing. Ongoing, coordinated effort, partnering, and support between stakeholders is essential to acquire the improved organizational processes and efficiencies required to meet the needs of the growing small payload community for low-cost access to space. Further, a mix of capabilities developed within the space community for Operationally Responsive Space, an international committee investigating space systems cross-compatibility, and an industry-based organization seeking small satellite "standardization" all work toward a new paradigm: sharing or leveraging resources amongst multiple users. The challenge: where are those users, and what is the best way to leverage them? What is leveraged-mass, power, cost-sharing? And how does one sort through these options? What policies may prevent the use of some options? Who are the "other users" that might share or leverage capabilities? This paper presents a systematic look at both the users and the launch options, and suggests a way forward.

Acute respiratory distress syndrome 40 years later: time to revisit its definition.

PubMed

Phua, Jason; Stewart, Thomas E; Ferguson, Niall D

2008-10-01

Acute respiratory distress syndrome is a common disorder associated with significant mortality and morbidity. The aim of this article is to critically evaluate the definition of acute respiratory distress syndrome and examine the impact the definition has on clinical practice and research. Articles from a MEDLINE search (1950 to August 2007) using the Medical Subject Heading respiratory distress syndrome, adult, diagnosis, limited to the English language and human subjects, their relevant bibliographies, and personal collections, were reviewed. The definition of acute respiratory distress syndrome is important to researchers, clinicians, and administrators alike. It has evolved significantly over the last 40 years, culminating in the American-European Consensus Conference definition, which was published in 1994. Although the American-European Consensus Conference definition is widely used, it has some important limitations that may impact on the conduct of clinical research, on resource allocation, and ultimately on the bedside management of such patients. These limitations stem partially from the fact that as defined, acute respiratory distress syndrome is a heterogeneous entity and also involve the reliability and validity of the criteria used in the definition. This article critically evaluates the American-European Consensus Conference definition and its limitations. Importantly, it highlights how these limitations may contribute to clinical trials that have failed to detect a potential true treatment effect. Finally, recommendations are made that could be considered in future definition modifications with an emphasis on the significance of accurately identifying the target population in future trials and subsequently in clinical care. How acute respiratory distress syndrome is defined has a significant impact on the results of randomized, controlled trials and epidemiologic studies. Changes to the current American-European Consensus Conference definition are likely to have an important role in advancing the understanding and management of acute respiratory distress syndrome.

Minimum standards on prevention, diagnosis and treatment of occupational and work-related skin diseases in Europe - position paper of the COST Action StanDerm (TD 1206).

PubMed

Alfonso, J H; Bauer, A; Bensefa-Colas, L; Boman, A; Bubas, M; Constandt, L; Crepy, M N; Goncalo, M; Macan, J; Mahler, V; Mijakoski, D; Ramada Rodilla, J M; Rustemeyer, T; Spring, P; John, S M; Uter, W; Wilkinson, M; Giménez-Arnau, A M

2017-06-01

Skin diseases constitute up to 40% of all notified occupational diseases in most European countries, predominantly comprising contact dermatitis, contact urticaria, and skin cancer. While insufficient prevention of work-related skin diseases (WRSD) is a top-priority problem in Europe, common standards for prevention of these conditions are lacking. To develop common European standards on prevention and management of WRSD and occupational skin diseases (OSD). Consensus amongst experts within occupational dermatology was achieved with regard to the definition of minimum evidence-based standards on prevention and management of WRSD/OSD. By definition, WRSDs/OSDs are (partially or fully) caused by occupational exposure. The definition of OSD sensu stricto additionally includes diverging national legal requirements, with an impact on registration, prevention, management, and compensation. With the implementation of the classification of WRSD/OSD in the International Classification of Diseases (ICD) 11th Revision in future, a valid surveillance and comparability across countries will be possible. Currently, WRDS and OSD are still under-reported. Depending on legislation and regulations, huge differences exist in notification procedures in Europe, although notification is crucial to prevent chronic and relapsing disease. Facilities for early diagnosis, essential for individual patient management, should be based on existing guidelines and include a multidisciplinary approach. Patch testing is essential if contact dermatitis persists or relapses. Workplace exposure assessment of WRSD/OSD requires full labelling of product ingredients on material safety data sheets helping to identify allergens, irritants and skin carcinogens. Comparable standards in primary, secondary and tertiary prevention must be established in Europe to reduce the burden of WRSD/OSD in Europe. The adoption of common European standards on prevention of WRSD/OSD will contribute to reduce the incidence of OSD and their socio-economic burden. © 2017 European Academy of Dermatology and Venereology.

Evolution of European Union legislation on emergency research.

PubMed

Mentzelopoulos, Spyros D; Mantzanas, Michail; van Belle, Gerald; Nichol, Graham

2015-06-01

Emergency research is necessary to prevent exposure of patients to unvalidated clinical practice (nonmaleficence), and to improve the dismal prognosis of disorders requiring emergent treatment such as cardiac arrest (beneficence). Regulations that govern clinical research should conform to bioethical principles of respect for nonmaleficence, beneficence, autonomy, and justice. Our objectives are to review the evolution of European Union (EU) legislation on emergency research, and to identify potentially remaining problems. EU legislative sources on clinical research and medical literature describing the impact of EU Regulations on emergency research. Article 5 of EU Directive 2001/20/EC required consent before enrolment in a research study to ensure the autonomy of potentially incapacitated research subjects. However, obtaining such consent is often impossible in emergency situations. Directive 2001/20/EC was criticized for potentially preventing emergency research. Several EU Member States addressed this problem by permitting deferred consent. International ethical guidelines supporting deferred consent were also cited by Good Clinical Practice Directive 2005/28/EC. However, Directive 2001/20/EC was not revised to achieve harmonization of EU emergency research, thus resulting in ongoing "ambiguity" as regards to emergency research legitimacy. This will be definitively addressed by applying EU Regulation No. 536/2014 and repealing Directive 2001/20/EC. The new EU Regulation permits using deferred consent under clearly specified conditions, and may foster emergency research that evaluates interventions posing minimal risk relative to standard practice. Legislation related to emergency research in Europe has evolved to increase concordance with bioethical principles so as to increase evidence-based improvements in emergency care. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

Quality of reporting of outcomes in phase III studies of pulmonary tuberculosis: a systematic review.

PubMed

Bonnett, Laura Jayne; Ken-Dror, Gie; Davies, Geraint Rhys

2018-02-21

Despite more than 60 years of clinical trials, tuberculosis (TB) still causes a high global burden of mortality and morbidity. Treatment currently requires multiple drugs in combination, taken over a prolonged period. New drugs are needed to shorten treatment duration, prevent resistance and reduce adverse events. However, to improve on current methodology in drug development, a more complete understanding of the existing clinical evidence base is required. A systematic review was undertaken to summarise outcomes reported in phase III trials of patients with newly diagnosed pulmonary TB. A systematic search of databases (PubMed, MEDLINE, EMBASE, CENTRAL and LILACs) was conducted on 30 November 2017 to retrieve relevant peer-reviewed articles. Reference lists of included studies were also searched. This systematic review considered all reported outcomes. Of 248 included studies, 229 considered "on-treatment" outcomes whilst 148 reported "off-treatment" outcomes. There was wide variation and ambiguity in the definition of reported outcomes, including their relationship to treatment and in the time points evaluated. Additional challenges were observed regarding the analysis approach taken (per protocol versus intention to treat) and the varying durations of "intensive" and "continuation" phases of treatment. Bacteriological outcomes were most frequently reported but radiological and clinical data were often included as an implicit or explicit component of the overall definition of outcome. Terminology used to define long-term outcomes in phase III trials is inconsistent, reflecting evolving differences in protocols and practices. For successful future cumulative meta-analysis, the findings of this review suggest that greater availability of individual patient data and the development of a core outcome set would be desirable. In the meantime, we propose a simple and logical approach which should facilitate combination of key evidence and inform improvements in the methodology of TB drug development and clinical trials.

78 FR 12622 - Control of Communicable Diseases: Foreign; Scope and Definitions

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-25

... Control of Communicable Diseases: Foreign; Scope and Definitions AGENCY: Centers for Disease Control and... of direct final rule. SUMMARY: The Centers for Disease Control and Prevention (CDC) within the... INFORMATION CONTACT: For questions concerning this notice: Ashley A. Marrone, JD, Centers for Disease Control...

49 CFR 541.4 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-10-01

... means the vehicle identification number required by part 565 of this chapter. [59 FR 64168, Dec. 13..., DEPARTMENT OF TRANSPORTATION FEDERAL MOTOR VEHICLE THEFT PREVENTION STANDARD § 541.4 Definitions. (a... surface means, with respect to a vehicle part, a surface that is not directly exposed to sun and...

49 CFR 541.4 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-10-01

... means the vehicle identification number required by part 565 of this chapter. [59 FR 64168, Dec. 13..., DEPARTMENT OF TRANSPORTATION FEDERAL MOTOR VEHICLE THEFT PREVENTION STANDARD § 541.4 Definitions. (a... surface means, with respect to a vehicle part, a surface that is not directly exposed to sun and...

49 CFR 541.4 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-10-01

... means the vehicle identification number required by part 565 of this chapter. [59 FR 64168, Dec. 13..., DEPARTMENT OF TRANSPORTATION FEDERAL MOTOR VEHICLE THEFT PREVENTION STANDARD § 541.4 Definitions. (a... surface means, with respect to a vehicle part, a surface that is not directly exposed to sun and...

49 CFR 541.4 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-10-01

... means the vehicle identification number required by part 565 of this chapter. [59 FR 64168, Dec. 13..., DEPARTMENT OF TRANSPORTATION FEDERAL MOTOR VEHICLE THEFT PREVENTION STANDARD § 541.4 Definitions. (a... surface means, with respect to a vehicle part, a surface that is not directly exposed to sun and...

30 CFR 56.4000 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Definitions. 56.4000 Section 56.4000 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND NONMETAL MINE SAFETY AND HEALTH SAFETY AND HEALTH STANDARDS-SURFACE METAL AND NONMETAL MINES Fire Prevention and Control § 56.4000...

30 CFR 57.4000 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Definitions. 57.4000 Section 57.4000 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND NONMETAL MINE SAFETY AND HEALTH SAFETY AND HEALTH STANDARDS-UNDERGROUND METAL AND NONMETAL MINES Fire Prevention and Control § 57...

43 CFR 9212.0-5 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 43 Public Lands: Interior 2 2013-10-01 2013-10-01 false Definitions. 9212.0-5 Section 9212.0-5 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR TECHNICAL SERVICES (9000) FIRE MANAGEMENT Wildfire Prevention § 9212.0-5...

43 CFR 9212.0-5 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 43 Public Lands: Interior 2 2012-10-01 2012-10-01 false Definitions. 9212.0-5 Section 9212.0-5 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR TECHNICAL SERVICES (9000) FIRE MANAGEMENT Wildfire Prevention § 9212.0-5...

43 CFR 9212.0-5 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 43 Public Lands: Interior 2 2014-10-01 2014-10-01 false Definitions. 9212.0-5 Section 9212.0-5 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR TECHNICAL SERVICES (9000) FIRE MANAGEMENT Wildfire Prevention § 9212.0-5...

24 CFR 35.305 - Definitions and other general requirements.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 24 Housing and Urban Development 1 2013-04-01 2013-04-01 false Definitions and other general requirements. 35.305 Section 35.305 Housing and Urban Development Office of the Secretary, Department of Housing and Urban Development LEAD-BASED PAINT POISONING PREVENTION IN CERTAIN RESIDENTIAL STRUCTURES...

24 CFR 35.905 - Definitions and other general requirements.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 24 Housing and Urban Development 1 2011-04-01 2011-04-01 false Definitions and other general requirements. 35.905 Section 35.905 Housing and Urban Development Office of the Secretary, Department of Housing and Urban Development LEAD-BASED PAINT POISONING PREVENTION IN CERTAIN RESIDENTIAL STRUCTURES...

24 CFR 35.905 - Definitions and other general requirements.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 24 Housing and Urban Development 1 2014-04-01 2014-04-01 false Definitions and other general requirements. 35.905 Section 35.905 Housing and Urban Development Office of the Secretary, Department of Housing and Urban Development LEAD-BASED PAINT POISONING PREVENTION IN CERTAIN RESIDENTIAL STRUCTURES...

24 CFR 35.305 - Definitions and other general requirements.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 24 Housing and Urban Development 1 2014-04-01 2014-04-01 false Definitions and other general requirements. 35.305 Section 35.305 Housing and Urban Development Office of the Secretary, Department of Housing and Urban Development LEAD-BASED PAINT POISONING PREVENTION IN CERTAIN RESIDENTIAL STRUCTURES...

24 CFR 35.905 - Definitions and other general requirements.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Definitions and other general requirements. 35.905 Section 35.905 Housing and Urban Development Office of the Secretary, Department of Housing and Urban Development LEAD-BASED PAINT POISONING PREVENTION IN CERTAIN RESIDENTIAL STRUCTURES...

24 CFR 35.905 - Definitions and other general requirements.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 24 Housing and Urban Development 1 2013-04-01 2013-04-01 false Definitions and other general requirements. 35.905 Section 35.905 Housing and Urban Development Office of the Secretary, Department of Housing and Urban Development LEAD-BASED PAINT POISONING PREVENTION IN CERTAIN RESIDENTIAL STRUCTURES...

24 CFR 35.905 - Definitions and other general requirements.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 24 Housing and Urban Development 1 2012-04-01 2012-04-01 false Definitions and other general requirements. 35.905 Section 35.905 Housing and Urban Development Office of the Secretary, Department of Housing and Urban Development LEAD-BASED PAINT POISONING PREVENTION IN CERTAIN RESIDENTIAL STRUCTURES...

24 CFR 35.305 - Definitions and other general requirements.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 24 Housing and Urban Development 1 2011-04-01 2011-04-01 false Definitions and other general requirements. 35.305 Section 35.305 Housing and Urban Development Office of the Secretary, Department of Housing and Urban Development LEAD-BASED PAINT POISONING PREVENTION IN CERTAIN RESIDENTIAL STRUCTURES...

24 CFR 35.205 - Definitions and other general requirements.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 24 Housing and Urban Development 1 2013-04-01 2013-04-01 false Definitions and other general requirements. 35.205 Section 35.205 Housing and Urban Development Office of the Secretary, Department of Housing and Urban Development LEAD-BASED PAINT POISONING PREVENTION IN CERTAIN RESIDENTIAL STRUCTURES...

24 CFR 35.205 - Definitions and other general requirements.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 24 Housing and Urban Development 1 2012-04-01 2012-04-01 false Definitions and other general requirements. 35.205 Section 35.205 Housing and Urban Development Office of the Secretary, Department of Housing and Urban Development LEAD-BASED PAINT POISONING PREVENTION IN CERTAIN RESIDENTIAL STRUCTURES...

24 CFR 35.305 - Definitions and other general requirements.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Definitions and other general requirements. 35.305 Section 35.305 Housing and Urban Development Office of the Secretary, Department of Housing and Urban Development LEAD-BASED PAINT POISONING PREVENTION IN CERTAIN RESIDENTIAL STRUCTURES...

24 CFR 35.305 - Definitions and other general requirements.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 24 Housing and Urban Development 1 2012-04-01 2012-04-01 false Definitions and other general requirements. 35.305 Section 35.305 Housing and Urban Development Office of the Secretary, Department of Housing and Urban Development LEAD-BASED PAINT POISONING PREVENTION IN CERTAIN RESIDENTIAL STRUCTURES...

24 CFR 35.205 - Definitions and other general requirements.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 24 Housing and Urban Development 1 2014-04-01 2014-04-01 false Definitions and other general requirements. 35.205 Section 35.205 Housing and Urban Development Office of the Secretary, Department of Housing and Urban Development LEAD-BASED PAINT POISONING PREVENTION IN CERTAIN RESIDENTIAL STRUCTURES...

24 CFR 35.205 - Definitions and other general requirements.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Definitions and other general requirements. 35.205 Section 35.205 Housing and Urban Development Office of the Secretary, Department of Housing and Urban Development LEAD-BASED PAINT POISONING PREVENTION IN CERTAIN RESIDENTIAL STRUCTURES...

24 CFR 35.205 - Definitions and other general requirements.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 24 Housing and Urban Development 1 2011-04-01 2011-04-01 false Definitions and other general requirements. 35.205 Section 35.205 Housing and Urban Development Office of the Secretary, Department of Housing and Urban Development LEAD-BASED PAINT POISONING PREVENTION IN CERTAIN RESIDENTIAL STRUCTURES...

Are cultural values and beliefs included in U.S. based HIV interventions?

PubMed

Wyatt, Gail E; Williams, John K; Gupta, Arpana; Malebranche, Dominique

2012-11-01

To determine the extent to which current United States based human immunodeficiency virus/acquired immune deficiency syndrome (HIV/AIDS) prevention and risk reduction interventions address and include aspects of cultural beliefs in definitions, curricula, measures and related theories that may contradict current safer sex messages. A comprehensive literature review was conducted to determine which published human immunodeficiency virus/acquired immune deficiency syndrome (HIV/AIDS) prevention and risk reduction interventions incorporated aspects of cultural beliefs. This review of 166 human immunodeficiency virus (HIV) prevention and risk reduction interventions, published between 1988 and 2010, identified 34 interventions that varied in cultural definitions and the integration of cultural concepts. human immunodeficiency virus (HIV) interventions need to move beyond targeting specific populations based upon race/ethnicity, gender, sexual, drug and/or risk behaviors and incorporate cultural beliefs and experiences pertinent to an individual's risk. Theory based interventions that incorporate cultural beliefs within a contextual framework are needed if prevention and risk reduction messages are to reach targeted at risk populations. Implications for the lack of uniformity of cultural definitions, measures and related theories are discussed and recommendations are made to ensure that cultural beliefs are acknowledged for their potential conflict with safer sex skills and practices. Copyright © 2011. Published by Elsevier Inc.

Prevention of Spacecraft Anomalies: The Role of Space Climate and Space Weather Models

NASA Technical Reports Server (NTRS)

Barth, Janet L.

2003-01-01

Space-based systems are developing into critical infrastructure to support the quality of life on Earth. Mission requirements along with rapidly evolving technologies have outpaced efforts to accommodate detrimental space environment impacts on systems. This chapter describes approaches to accommodate space climate and space weather impacts on systems and notes areas where gaps in model development limit our ability to prevent spacecraft anomalies.

Countering Extremism: An Understanding of the Problem, the Process and Some Solutions

DTIC Science & Technology

2015-06-01

Radicalization into Terrorism.” 20 extremist movement “could not be developed , evolved or sustained over time and place” without the support of...efforts to research, develop , and implement a variety of methods and models to prevent and counter violent extremism (CVE). Despite these efforts...but how to better understand the radicalization process in order to develop effective strategies to prevent radicalization from occurring. Faced

Investigation of Evolved Paraoxonase-1 Variants for Prevention of Organophosphorous Pesticide Compound Intoxication

DTIC Science & Technology

2014-04-04

protection below a paraoxon to enzyme ratio of 8:1, whereas higher ratios produced tremors and/or mortality. VII- D11 in mouse blood co-eluted with high...are a benefit to society through increasing food production, preserving produce , and combating insect infestations. However, due to their inherent...lethality, they induce side effects and are generally unable to prevent post-exposure incapacitation, convulsions, performance deficits, or

The burden of proof: The current state of atrial fibrillation prevention and treatment trials

PubMed Central

Zakeri, Rosita; Van Wagoner, David R.; Calkins, Hugh; Wong, Tom; Ross, Heather M.; Heist, E. Kevin; Meyer, Timothy E.; Kowey, Peter R.; Mentz, Robert J.; Cleland, John G.; Pitt, Bertram; Zannad, Faiez; Linde, Cecilia

2017-01-01

Atrial fibrillation (AF) is an age-related arrhythmia of enormous socioeconomic significance. In recent years, our understanding of the basic mechanisms that initiate and perpetuate AF has evolved rapidly, catheter ablation of AF has progressed from concept to reality, and recent studies suggest lifestyle modification may help prevent AF recurrence. Emerging developments in genetics, imaging, and informatics also present new opportunities for personalized care. However, considerable challenges remain. These include a paucity of studies examining AF prevention, modest efficacy of existing antiarrhythmic therapies, diverse ablation technologies and practice, and limited evidence to guide management of high-risk patients with multiple comorbidities. Studies examining the long-term effects of AF catheter ablation on morbidity and mortality outcomes are not yet completed. In many ways, further progress in the field is heavily contingent on the feasibility, capacity, and efficiency of clinical trials to incorporate the rapidly evolving knowledge base and to provide substantive evidence for novel AF therapeutic strategies. This review outlines the current state of AF prevention and treatment trials, including the foreseeable challenges, as discussed by a unique forum of clinical trialists, scientists, and regulatory representatives in a session endorsed by the Heart Rhythm Society at the 12th Global CardioVascular Clinical Trialists Forum in Washington, DC, December 3–5, 2015. PMID:28161513

Spatio-Temporal Data Model for Integrating Evolving Nation-Level Datasets

NASA Astrophysics Data System (ADS)

Sorokine, A.; Stewart, R. N.

2017-10-01

Ability to easily combine the data from diverse sources in a single analytical workflow is one of the greatest promises of the Big Data technologies. However, such integration is often challenging as datasets originate from different vendors, governments, and research communities that results in multiple incompatibilities including data representations, formats, and semantics. Semantics differences are hardest to handle: different communities often use different attribute definitions and associate the records with different sets of evolving geographic entities. Analysis of global socioeconomic variables across multiple datasets over prolonged time is often complicated by the difference in how boundaries and histories of countries or other geographic entities are represented. Here we propose an event-based data model for depicting and tracking histories of evolving geographic units (countries, provinces, etc.) and their representations in disparate data. The model addresses the semantic challenge of preserving identity of geographic entities over time by defining criteria for the entity existence, a set of events that may affect its existence, and rules for mapping between different representations (datasets). Proposed model is used for maintaining an evolving compound database of global socioeconomic and environmental data harvested from multiple sources. Practical implementation of our model is demonstrated using PostgreSQL object-relational database with the use of temporal, geospatial, and NoSQL database extensions.

Experimenters' reference based upon Skylab experiment management

NASA Technical Reports Server (NTRS)

1974-01-01

The methods and techniques for experiment development and integration that evolved during the Skylab Program are described to facilitate transferring this experience to experimenters in future manned space programs. Management responsibilities and the sequential process of experiment evolution from initial concept through definition, development, integration, operation and postflight analysis are outlined and amplified, as appropriate. Emphasis is placed on specific lessons learned on Skylab that are worthy of consideration by future programs.

Electron Multipactor: Theory Review, Comparison and Modeling of Mitigation Techniques in ICEPIC

DTIC Science & Technology

2009-03-01

dielectric . This development includes space charge effects . 2.2.1 Conventions, Notations and Definitions...gigawatts, one percent of the RF energy would indeed be enough to cause failure in the dielectric window. For the case in which space charge effects are...buildup of the space - charges along the dielectric surface not allowing the number of multipactoring electrons to evolve beyond a certain point. 0 2 4 6

En Route Critical Care: Evolving, Improving & Advancing Capabilities

DTIC Science & Technology

2011-01-26

Neonatal Intensive Care – Burn Team – Acute Lung Team 18 2011 MHS Conference OCONUS Medical Center/ASF INTRA-THEATER INTER-THEATER Theater...MASF, FST Theater Hospital Care Forward Resuscitative Care 68W, PA, FS, PJ, 4N, RN, SOFME/SOCCET, CCATT Battalion Aid Station SABC/TCCC US Medical...Lvl-II/Forward Surgical Teams Damage Control Surgery/ Resuscitation Lvl-III/CSH, EMEDS, EMF Theater Hospitals Definitive Care GOAL: Maintain

The Wigner function in the relativistic quantum mechanics

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kowalski, K., E-mail: kowalski@uni.lodz.pl; Rembieliński, J.

2016-12-15

A detailed study is presented of the relativistic Wigner function for a quantum spinless particle evolving in time according to the Salpeter equation. - Highlights: • We study the Wigner function for a quantum spinless relativistic particle. • We discuss the relativistic Wigner function introduced by Zavialov and Malokostov. • We introduce relativistic Wigner function based on the standard definition. • We find analytic expressions for relativistic Wigner functions.

Why Do Teenagers Smoke and Chew?

ERIC Educational Resources Information Center

Landers, Cassie; Orlandi, Mario A.

1987-01-01

The authors discuss the factors related to the acquisition of adolescent smoking and describe intervention programs that have evolved to prevent smoking. They hypothesize that the same correlates would apply to smokeless tobacco use among this age group. (CH)

Industrial paramedics, out on site but not out of mind.

PubMed

Acker, Joseph J; Johnston, Tania M; Lazarsfeld-Jensen, Ann

2014-01-01

Australian natural resource exploration and production companies are employing paramedics to provide emergency medical response, primary health care, injury prevention, and health promotion services in remote locations nationally and internationally. Although Australian paramedic practice has steadily evolved to include increasingly complex medical interventions in the prehospital setting, paramedics are not yet registered health professionals, and in many states and territories their title is not protected. Similarly, tertiary-level education is becoming the entry to practice standard for traditional ambulance paramedics; however, certificate- and diploma-level paramedic courses remain an acceptable pathway to private and industrial paramedic jobs. To ensure acceptable patient safety standards are maintained and to protect all related stakeholders, the role, skills, training, and professional capacity of industrial paramedics must be defined. The study objective was to explore the published literature for a definition for the discipline of industrial paramedicine. A comprehensive systematic analysis was conducted using the EBSCOhost (health), MEDLINE, SCOPUS, and CINAHL electronic databases. The primary search terms "remote", "offshore", "mining", and "oil" were combined with the secondary search terms "paramedic" and "emergency medical services". An initial search using the combined two-term sets identified 870 citations. After application of the inclusion and exclusion criteria to a title and abstract review, 69 citations met the criteria including those discovered by searching the reference lists. Of these, nine citations were excluded because full-text papers could not be found and eight citations were excluded based on review of the full article. The result was 40 articles that discuss the role of paramedics in the remote or offshore environment (ROP) and 12 articles that discuss the provision of emergency medical services in the mining or oil and gas sectors (MOEMS). There is no single definition or comprehensive role description for industrial paramedic practice within the literature. Worldwide, there is little high-quality published evidence to adequately reflect all aspects of industrial paramedic practice. However, based on the literature available, this definition is offered: 'An industrial paramedic is an advanced clinical practitioner in paramedicine with an expanded scope of practice. The industrial paramedic provides emergency response, primary health care, chronic disease management, injury prevention, health promotion, medical referral, and repatriation coordination at remote mining sites, offshore installations, and other isolated industry settings. The industrial paramedic is resourceful, adaptable, and comfortable working independently. Industrial paramedics practice on site with limited resources, remotely located from tertiary care, and use telemedicine to consult with other health professionals as required. Industrial paramedics are experts at rapidly assessing, prioritising, and establishing control in their unpredictable workspace to reduce risks and create an environment conducive to quality patient care. The industrial paramedic preferably holds a specialised tertiary qualification and is committed to maintaining their clinical competency through continuing professional development.' Further research is required to validate, refute, or expand this proposed definition.

Another Piece of the Antibody Puzzle: Observations from the HALT study\\.

PubMed

Snyder, Laurie D; Tinckam, Kathryn J

2018-06-04

In the rapidly evolving domain of clinical transplantation immunobiology, the interrogation and interpretation of HLA antibodies and their associated clinical consequences are in the spotlight. In lung transplant, HLA antibodies, in particular donor specific antibodies (DSA), are a determining component of the lung transplant antibody mediated rejection (AMR) definition (1). DSA after lung transplant are widely regarded as poor prognosticator, though sparse data to date necessitate ongoing discourse and continued investigation into incidence, timing and treatment. Prior studies reported a wide range of DSA incidence with differing consequences on a background of highly variable timing, methods, antibody analytic strategies and clinical definitions. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.

Evolution of the LBT Telemetry System

NASA Astrophysics Data System (ADS)

Summers, K.; Biddick, C.; De La Peña, M. D.; Summers, D.

2014-05-01

The Large Binocular Telescope (LBT) Telescope Control System (TCS) records about 10GB of telemetry data per night. Additionally, the vibration monitoring system records about 9GB of telemetry data per night. Through 2013, we have amassed over 6TB of Hierarchical Data Format (HDF5) files and almost 9TB in a MySQL database of TCS and vibration data. The LBT telemetry system, in its third major revision since 2004, provides the mechanism to capture and store this data. The telemetry system has evolved from a simple HDF file system with MySQL stream definitions within the TCS, to a separate system using a MySQL database system for the definitions and data, and finally to no database use at all, using HDF5 files.

IDEF3 formalization report

NASA Technical Reports Server (NTRS)

Menzel, Christopher; Mayer, Richard J.; Edwards, Douglas D.

1991-01-01

The Process Description Capture Method (IDEF3) is one of several Integrated Computer-Aided Manufacturing (ICAM) DEFinition methods developed by the Air Force to support systems engineering activities, and in particular, to support information systems development. These methods have evolved as a distillation of 'good practice' experience by information system developers and are designed to raise the performance level of the novice practitioner to one comparable with that of an expert. IDEF3 is meant to serve as a knowledge acquisition and requirements definition tool that structures the user's understanding of how a given process, event, or system works around process descriptions. A special purpose graphical language accompanying the method serves to highlight temporal precedence and causality relationships relative to the process or event being described.

Evolution of the INMARSAT aeronautical system: Service, system, and business considerations

NASA Technical Reports Server (NTRS)

Sengupta, Jay R.

1995-01-01

A market-driven approach was adopted to develop enhancements to the Inmarsat-Aeronautical system, to address the requirements of potential new market segments. An evolutionary approach and well differentiated product/service portfolio was required, to minimize system upgrade costs and market penetration, respectively. The evolved system definition serves to minimize equipment cost/size/mass for short/medium range aircraft, by reducing the antenna gain requirement and relaxing the performance requirements for non safety-related communications. A validation program involving simulation, laboratory tests, over-satellite tests and flight trials is being conducted to confirm the system definition. Extensive market research has been conducted to determine user requirements and to quantify market demand for future Inmarsat Aero-1 AES, using sophisticated computer assisted survey techniques.

76 FR 61376 - NIMS Public Works Resources: Typed Resource Definitions (FEMA 508-7)

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-04

...] NIMS Public Works Resources: Typed Resource Definitions (FEMA 508-7) AGENCY: Federal Emergency... Management Agency (FEMA) is requesting public comments on the NIMS Public Works Resources: Typed Resource..., nongovernmental organizations, and the private sector to work together to prevent, protect against, respond to...

A Comprehensive Definition of Plagiarism.

ERIC Educational Resources Information Center

Liddell, Jean

2003-01-01

Explains how the internet has made it easy for students to plagiarize papers. Gives definitions for plagiarism. Explains reasons why students plagiarize including the following: they don't understand what it is, they think they won't get caught, etc. Describes ways to detect and prevent plagiarism. (ontains 58 references.)(MZ)

75 FR 81868 - Approval and Promulgation of Implementation Plans; Kentucky: Prevention of Significant...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-29

... ethanol through a natural fermentation process from the definition of ``chemical process plants'' in the... through a natural fermentation process from the definition of ``chemical process plants'' in the major NSR... facilities producing ethanol by natural fermentation under the North American Industry Classification System...

75 FR 55988 - Approval and Promulgation of Implementation Plans; Commonwealth of Kentucky; Prevention of...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-15

... exclude facilities that produce ethanol through a natural fermentation process from the definition of... action on Kentucky's provisions to exclude facilities that produce ethanol through a natural fermentation... facilities that produce ethanol through a natural fermentation process from the definition of ``chemical...

40 CFR 112.5 - Amendment of Spill Prevention, Control, and Countermeasure Plan by owners or operators.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 23 2012-07-01 2012-07-01 false Amendment of Spill Prevention, Control, and Countermeasure Plan by owners or operators. 112.5 Section 112.5 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS OIL POLLUTION PREVENTION Applicability, Definitions, and General Requirements for All...

40 CFR 112.5 - Amendment of Spill Prevention, Control, and Countermeasure Plan by owners or operators.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 22 2014-07-01 2013-07-01 true Amendment of Spill Prevention, Control, and Countermeasure Plan by owners or operators. 112.5 Section 112.5 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS OIL POLLUTION PREVENTION Applicability, Definitions, and General Requirements for All Facilitie...

40 CFR 112.5 - Amendment of Spill Prevention, Control, and Countermeasure Plan by owners or operators.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 21 2010-07-01 2010-07-01 false Amendment of Spill Prevention, Control, and Countermeasure Plan by owners or operators. 112.5 Section 112.5 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS OIL POLLUTION PREVENTION Applicability, Definitions, and General Requirements for All...

40 CFR 112.5 - Amendment of Spill Prevention, Control, and Countermeasure Plan by owners or operators.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 23 2013-07-01 2013-07-01 false Amendment of Spill Prevention, Control, and Countermeasure Plan by owners or operators. 112.5 Section 112.5 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS OIL POLLUTION PREVENTION Applicability, Definitions, and General Requirements for All...

40 CFR 112.5 - Amendment of Spill Prevention, Control, and Countermeasure Plan by owners or operators.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 22 2011-07-01 2011-07-01 false Amendment of Spill Prevention, Control, and Countermeasure Plan by owners or operators. 112.5 Section 112.5 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS OIL POLLUTION PREVENTION Applicability, Definitions, and General Requirements for All...

Conceptualizing the Engaging Bystander Approach to Sexual Violence Prevention on College Campuses

ERIC Educational Resources Information Center

McMahon, Sarah; Postmus, Judy L.; Koenick, Ruth Anne

2011-01-01

Bystander intervention offers promise as a sexual violence prevention tool for student affairs administrators on college campuses, but the conceptualization and definition of the approach is in its infancy and needs further development. In an effort to emphasize the potential role of bystanders in the primary prevention of sexual violence, we put…

A Cost Analysis Plan for the National Preventive Dentistry Demonstration Program.

ERIC Educational Resources Information Center

Foch, Craig B.

The National Preventive Dentistry Demonstration Project (NPDDP) delivers school-based preventive dental care to approximately 14,000 children in ten United States cities. The program, begun in 1976, is to be conducted over a six and one-half year period. The costing definitions and allocation rules to be used in the project are the principal…

Exploring the diversity of conceptualizations of work (dis)ability: a scoping review of published definitions.

PubMed

Lederer, Valérie; Loisel, Patrick; Rivard, Michèle; Champagne, François

2014-06-01

Researchers are confronted to numerous definitions of work ability/disability, influenced by their context of emergence, discipline, purpose, underlying paradigm and relationship to time. This study provides an in-depth analysis of the concept through a systematic scoping review and the development of an integrative concept map of work (dis)ability. The research questions are: How has work (dis)ability been conceptualized from the perspectives of research, practice, policy and industry in the published scientific literature? How has the conceptualization of work (dis)ability evolved over time? A search strategy was designed with a library scientist to retrieve scientific publications containing explicit definition(s) of work (dis)ability in leading-edge databases. The screening and the extraction of the definitions were achieved by duplicate assessment. The definitions were subject to a comparative analysis based on the grounded theory approach. In total, 423 abstracts were retrieved from the bibliographic databases. After removing duplicates, 280 unique records were screened for inclusion. A final set of 115 publications containing unique original conceptual definitions served as basis for analysis. The scientific literature does not reflect a shared, integrated vision of the exact nature and dimensions of work (dis)ability. However, except for a few definitions, there seems to be a consensus that work (dis)ability is a relational concept resulting from the interaction of multiple dimensions that influence each other through different ecological levels. The conceptualization of work (dis)ability also seems to have become more dynamic over time. The way work (dis)ability is defined has important implications for research, compensation and rehabilitation.

Assessing the evolving definition of underrepresented minority and its application in academic medicine.

PubMed

Page, Kathleen Raquel; Castillo-Page, Laura; Poll-Hunter, Norma; Garrison, Gwen; Wright, Scott M

2013-01-01

To assess how U.S. academic health centers (AHCs) define the term underrepresented minority (URM) and apply it to their diversity programs, following the 2003 revision of the Association of American Medical Colleges' (AAMC's) definition of URM. In 2010, the authors developed and deployed a cross-sectional survey of diversity leaders at 106 AHCs. The survey included questions about the diversity leader and institution's diversity program; institution's URM definition; application of that definition; and the diversity leader's perceptions of the representation and institutional contribution of various ethnic/racial groups. The authors used descriptive statistics to analyze the results. Of the 106 diversity leaders invited, 89 (84.0%) responded and 78 (73.6%) provided a working definition of URM. Most programs (40/78; 51%) used the 2003 AAMC definition of URM, which includes racial/ethnic groups that are underrepresented in medicine relative to local and national demographics. Only 14.1% (11/78) used the pre-2003 AAMC definition, which included only African Americans, Mexican Americans, Native Americans, and mainland Puerto Ricans. Approximately one-third (23/78; 29.5%) also considered other diversity factors, such as socioeconomic status, sexual orientation, and disability, in defining URM. Fifty-eight respondents (74.4%) confirmed that their diversity programs targeted specific groups. The definition of URM used by diversity programs at U.S. AHCs varied widely. Although some classified URMs by racial/ethnic categories, the majority defined URM more broadly to encompass other demographic and personal characteristics. This shift should prepare academic medicine to eliminate health disparities and meet the health needs of an increasingly diverse population.

Have plants evolved to self-immolate?

PubMed Central

Bowman, David M. J. S.; French, Ben J.; Prior, Lynda D.

2014-01-01

By definition fire prone ecosystems have highly combustible plants, leading to the hypothesis, first formally stated by Mutch in 1970, that community flammability is the product of natural selection of flammable traits. However, proving the “Mutch hypothesis” has presented an enormous challenge for fire ecologists given the difficulty in establishing cause and effect between landscape fire and flammable plant traits. Individual plant traits (such as leaf moisture content, retention of dead branches and foliage, oil rich foliage) are known to affect the flammability of plants but there is no evidence these characters evolved specifically to self-immolate, although some of these traits may have been secondarily modified to increase the propensity to burn. Demonstrating individual benefits from self-immolation is extraordinarily difficult, given the intersection of the physical environmental factors that control landscape fire (fuel production, dryness and ignitions) with community flammability properties that emerge from numerous traits of multiple species (canopy cover and litter bed bulk density). It is more parsimonious to conclude plants have evolved mechanisms to tolerate, but not promote, landscape fire. PMID:25414710

Carbon and Sulfur Isotopic Composition of Rocknest Soil as Determined with the Sample Analysis at Mars(SAM) Quadrupole Mass Spectrometer

NASA Technical Reports Server (NTRS)

Franz, H. B.; McAdam, C.; Stern, J. C.; Archer, P. D., Jr.; Sutter, B.; Grotzinger, J. P.; Jones, J. H.; Leshin, L. A.; Mahaffy, P. R.; Ming, D. W.;

eHealth literacy research-Quo vadis?

PubMed

Griebel, Lena; Enwald, Heidi; Gilstad, Heidi; Pohl, Anna-Lena; Moreland, Julia; Sedlmayr, Martin

2017-10-18

The concept of electronic health (eHealth) literacy evolved from the social and information sciences and describes competencies necessary to use electronic health services. As it is a rather new topic, and as there is no current overview of the state of the art in research, it is not possible to identify research gaps. Therefore, the objective of this viewpoint article is to increase knowledge on the current state of the art of research in eHealth literacy and to identify gaps in scientific research which should be focused on by the research community in the future. The article provides a current viewpoint of the concept of eHealth literacy and related research. Gaps can be found in terms of a missing "gold standard" regarding both the definition and the measurement of eHealth literacy. Furthermore, there is a need for identifying the implications on eHealth developers, which evolve from the measurement of eHealth literacy in eHealth users. Finally, a stronger inclusion of health professionals, both in the evolving concept and in the measurement of eHealth literacy, is needed in the future.

42 CFR 52a.2 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-10-01

... clinical research into the cause, diagnosis, early detection, prevention, control, and treatment of autism... conducting basic and clinical research into, training in, and demonstration of advanced diagnostic, control..., psychological, prevention and treatment research and related activities on breast cancer; (d) For purposes of...

42 CFR 52a.2 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-10-01

... clinical research into the cause, diagnosis, early detection, prevention, control, and treatment of autism... conducting basic and clinical research into, training in, and demonstration of advanced diagnostic, control..., psychological, prevention and treatment research and related activities on breast cancer; (d) For purposes of...

42 CFR 52a.2 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-10-01

... clinical research into the cause, diagnosis, early detection, prevention, control, and treatment of autism... conducting basic and clinical research into, training in, and demonstration of advanced diagnostic, control..., psychological, prevention and treatment research and related activities on breast cancer; (d) For purposes of...

42 CFR 52a.2 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-10-01

... clinical research into the cause, diagnosis, early detection, prevention, control, and treatment of autism... conducting basic and clinical research into, training in, and demonstration of advanced diagnostic, control..., psychological, prevention and treatment research and related activities on breast cancer; (d) For purposes of...

42 CFR 52a.2 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-10-01

... clinical research into the cause, diagnosis, early detection, prevention, control, and treatment of autism... conducting basic and clinical research into, training in, and demonstration of advanced diagnostic, control..., psychological, prevention and treatment research and related activities on breast cancer; (d) For purposes of...

24 CFR 576.3 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-04-01

... counseling. (4) Nutritional counseling. (5) Substance abuse treatment and counseling. (6) Assistance in... 42 U.S.C. 11302. Homeless prevention means activities or programs designed to prevent the incidence... COMMUNITY FACILITIES EMERGENCY SHELTER GRANTS PROGRAM: STEWART B. McKINNEY HOMELESS ASSISTANCE ACT General...

24 CFR 576.3 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-04-01

... counseling. (4) Nutritional counseling. (5) Substance abuse treatment and counseling. (6) Assistance in... 42 U.S.C. 11302. Homeless prevention means activities or programs designed to prevent the incidence... COMMUNITY FACILITIES EMERGENCY SHELTER GRANTS PROGRAM: STEWART B. McKINNEY HOMELESS ASSISTANCE ACT General...

The role of social toxicity in responses to a slowly-evolving environmental disaster: the case of amphibole asbestos exposure in Libby, Montana, USA.

PubMed

Cline, Rebecca J W; Orom, Heather; Chung, Jae Eun; Hernandez, Tanis

2014-09-01

Experiencing a disaster has significant negative effects on psychological adjustment. Case study accounts point to two consistent trends in slowly-evolving environmental disasters: (a) patterns of negative social dynamics, and (b) relatively worse psychological outcomes than in natural disasters. Researchers have begun to explicitly postulate that the social consequences of slowly-evolving environmental disasters (e.g., community conflict) have their own effects on victims' psychological outcomes. This study tested a model of the relationship between those social consequences and psychological adjustment of victims of a slowly-evolving environmental disaster, specifically those whose health has been compromised by the amphibole asbestos disaster in Libby, MT. Results indicate that experiencing greater community conflict about the disaster was associated with greater family conflict about the disaster which, in turn, was associated with greater social constraints on talking with others about their disease, both directly and indirectly through experiencing stigmatization. Experiencing greater social constraints was associated with worse psychological adjustment, both directly and indirectly through failed social support. Findings have implications for understanding pathways by which social responses create negative effects on mental health in slowly-evolving environmental disasters. These pathways suggest points for prevention and response (e.g., social support, stigmatization of victims) for communities experiencing slowly-evolving environmental disasters.

Evolutionary robotics simulations help explain why reciprocity is rare in nature

PubMed Central

André, Jean-Baptiste; Nolfi, Stefano

2016-01-01

The relative rarity of reciprocity in nature, contrary to theoretical predictions that it should be widespread, is currently one of the major puzzles in social evolution theory. Here we use evolutionary robotics to solve this puzzle. We show that models based on game theory are misleading because they neglect the mechanics of behavior. In a series of experiments with simulated robots controlled by artificial neural networks, we find that reciprocity does not evolve, and show that this results from a general constraint that likely also prevents it from evolving in the wild. Reciprocity can evolve if it requires very few mutations, as is usually assumed in evolutionary game theoretic models, but not if, more realistically, it requires the accumulation of many adaptive mutations. PMID:27616139

Health literacy and public health: A systematic review and integration of definitions and models

PubMed Central

2012-01-01

Background Health literacy concerns the knowledge and competences of persons to meet the complex demands of health in modern society. Although its importance is increasingly recognised, there is no consensus about the definition of health literacy or about its conceptual dimensions, which limits the possibilities for measurement and comparison. The aim of the study is to review definitions and models on health literacy to develop an integrated definition and conceptual model capturing the most comprehensive evidence-based dimensions of health literacy. Methods A systematic literature review was performed to identify definitions and conceptual frameworks of health literacy. A content analysis of the definitions and conceptual frameworks was carried out to identify the central dimensions of health literacy and develop an integrated model. Results The review resulted in 17 definitions of health literacy and 12 conceptual models. Based on the content analysis, an integrative conceptual model was developed containing 12 dimensions referring to the knowledge, motivation and competencies of accessing, understanding, appraising and applying health-related information within the healthcare, disease prevention and health promotion setting, respectively. Conclusions Based upon this review, a model is proposed integrating medical and public health views of health literacy. The model can serve as a basis for developing health literacy enhancing interventions and provide a conceptual basis for the development and validation of measurement tools, capturing the different dimensions of health literacy within the healthcare, disease prevention and health promotion settings. PMID:22276600

Defining Bladder Health in Women and Girls: Implications for Research, Clinical Practice, and Public Health Promotion.

PubMed

Lukacz, Emily S; Bavendam, Tamara G; Berry, Amanda; Fok, Cynthia S; Gahagan, Sheila; Goode, Patricia S; Hardacker, Cecilia T; Hebert-Beirne, Jeni; Lewis, Cora E; Lewis, Jessica; Low, Lisa Kane; Lowder, Jerry L; Palmer, Mary H; Smith, Ariana L; Brady, Sonya S

2018-05-24

Bladder health in women and girls is poorly understood, in part, due to absence of a definition for clinical or research purposes. This article describes the process used by a National Institutes of Health funded transdisciplinary research team (The Prevention of Lower Urinary Tract Symptoms [PLUS] Consortium) to develop a definition of bladder health. The PLUS Consortium identified currently accepted lower urinary tract symptoms (LUTS) and outlined elements of storage and emptying functions of the bladder. Consistent with the World Health Organization's definition of health, PLUS concluded that absence of LUTS was insufficient and emphasizes the bladder's ability to adapt to short-term physical, psychosocial, and environmental challenges for the final definition. Definitions for subjective experiences and objective measures of bladder dysfunction and health were drafted. An additional bioregulatory function to protect against infection, neoplasia, chemical, or biologic threats was proposed. PLUS proposes that bladder health be defined as: "A complete state of physical, mental, and social well-being related to bladder function and not merely the absence of LUTS. Healthy bladder function permits daily activities, adapts to short-term physical or environmental stressors, and allows optimal well-being (e.g., travel, exercise, social, occupational, or other activities)." Definitions for each element of bladder function are reported with suggested subjective and objective measures. PLUS used a comprehensive transdisciplinary process to develop a bladder health definition. This will inform instrument development for evaluation of bladder health promotion and prevention of LUTS in research, practice, and public health initiatives.

How Does Definition of Minimum Break Length Affect Objective Measures of Sitting Outcomes Among Office Workers?

PubMed

Kloster, Stine; Danquah, Ida Høgstedt; Holtermann, Andreas; Aadahl, Mette; Tolstrup, Janne Schurmann

2017-01-01

Harmful health effects associated with sedentary behavior may be attenuated by breaking up long periods of sitting by standing or walking. However, studies assess interruptions in sitting time differently, making comparisons between studies difficult. It has not previously been described how the definition of minimum break duration affects sitting outcomes. Therefore, the aim was to address how definitions of break length affect total sitting time, number of sit-to-stand transitions, prolonged sitting periods and time accumulated in prolonged sitting periods among office workers. Data were collected from 317 office workers. Thigh position was assessed with an ActiGraph GT3X+ fixed on the right thigh. Data were exported with varying bout length of breaks. Afterward, sitting outcomes were calculated for the respective break lengths. Absolute numbers of sit-to-stand transitions decreased, and number of prolonged sitting periods and total time accumulated in prolonged sitting periods increased, with increasing minimum break length. Total sitting time was not influenced by varying break length. The definition of minimum break length influenced the sitting outcomes with the exception of total sitting time. A standard definition of break length is needed for comparison and interpretation of studies in the evolving research field of sedentary behavior.

Sexual Harassment: The Current State of the Law Governing Educational Institutions.

ERIC Educational Resources Information Center

Wetherfield, Alison

1990-01-01

Surveys federal law prohibiting sexual harassment as it applies to colleges. Concludes that sexual harassment law is still evolving, pursuing and defending harassment cases are traumatic activities, and that prevention is better than cure. (ABL)

[HIV prevention program for young people--the WYSH Project as a model of "combination prevention"].

PubMed

Ono-Kihara, Masako

2010-03-01

In face of the HIV pandemic that still grows, unsuccessful efforts of developing biomedical control measures or the failure of cognitive-behavioral approach to show sustained social level effectiveness, behavioral strategy is now expected to evolve into a structural prevention ("combination prevention") that involves multiple behavioral goals and multilevel approaches. WYSH Project is a combination prevention project for youth developed through socio-epidemiological approach that integrates epidemiology with social science such as social marketing and mixed method. WYSH Project includes mass education programs for youth in schools and programs for out-of-school youth through cyber network and peer communication. Started in 2002, it expanded nationwide with supports from related ministries and parent-teacher associations and has grown into a single largest youth prevention project in Japan.

Deception in advertising and marketing: ethical applications in rehabilitation.

PubMed

Banja, J D

1994-09-01

A much discussed issue in contemporary discussions of health care reform is the considerable competition that is anticipated to occur among providers. An inevitable aspect of this competition will be the ways health care services are presented in the marketplace through advertising and other forms of promotional literature. Considerable concern has already emerged among certain rehabilitation professionals, however, that advertising and marketing practices in rehabilitation must cohere with ethical standards. This article will discuss certain aspects of those standards, particularly as they have evolved from the Federal Trade Commission's definition of and rulings on deceptive practices in advertising. Salient aspects of the Commission's 1983 definition of deception will be related to rehabilitation by way of examining instances of rehabilitation advertising and marketing that might satisfy the Commission's definition of deception. The article will conclude with certain recommendations, principally drawn from various Federal Trade Commission rulings, that might be useful to individuals or corporate entities who advertise or market rehabilitation services.

29 CFR 2.31 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-07-01

... mentoring programs; and (5) Services for the prevention and treatment of juvenile delinquency and substance abuse, services for the prevention of crime and the provision of assistance to the victims and the... Secretary of Labor GENERAL REGULATIONS Equal Treatment in Department of Labor Programs for Religious...

29 CFR 2.31 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-07-01

... mentoring programs; and (5) Services for the prevention and treatment of juvenile delinquency and substance abuse, services for the prevention of crime and the provision of assistance to the victims and the... of Labor GENERAL REGULATIONS Equal Treatment in Department of Labor Programs for Religious...

29 CFR 2.31 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-07-01

... mentoring programs; and (5) Services for the prevention and treatment of juvenile delinquency and substance abuse, services for the prevention of crime and the provision of assistance to the victims and the... Secretary of Labor GENERAL REGULATIONS Equal Treatment in Department of Labor Programs for Religious...

29 CFR 2.31 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-07-01

... mentoring programs; and (5) Services for the prevention and treatment of juvenile delinquency and substance abuse, services for the prevention of crime and the provision of assistance to the victims and the... Secretary of Labor GENERAL REGULATIONS Equal Treatment in Department of Labor Programs for Religious...

Approaches to Drug Abuse Prevention

ERIC Educational Resources Information Center

Gordon, Paula D.

1971-01-01

This article concerns the drug abuse related definitions of the words education" and prevention" as they have come to be used today. The writer infers that the changing uses of these words reflects an increasingly more enlightened approach to ameliorating the problem of drug abuse. (Author)

A crucial step toward realism: responses to climate change from an evolving metacommunity perspective.

PubMed

Urban, Mark C; De Meester, Luc; Vellend, Mark; Stoks, Robby; Vanoverbeke, Joost

2012-02-01

We need to understand joint ecological and evolutionary responses to climate change to predict future threats to biological diversity. The 'evolving metacommunity' framework emphasizes that interactions between ecological and evolutionary mechanisms at both local and regional scales will drive community dynamics during climate change. Theory suggests that ecological and evolutionary dynamics often interact to produce outcomes different from those predicted based on either mechanism alone. We highlight two of these dynamics: (i) species interactions prevent adaptation of nonresident species to new niches and (ii) resident species adapt to changing climates and thereby prevent colonization by nonresident species. The rate of environmental change, level of genetic variation, source-sink structure, and dispersal rates mediate between these potential outcomes. Future models should evaluate multiple species, species interactions other than competition, and multiple traits. Future experiments should manipulate factors such as genetic variation and dispersal to determine their joint effects on responses to climate change. Currently, we know much more about how climates will change across the globe than about how species will respond to these changes despite the profound effects these changes will have on global biological diversity. Integrating evolving metacommunity perspectives into climate change biology should produce more accurate predictions about future changes to species distributions and extinction threats.

A crucial step toward realism: responses to climate change from an evolving metacommunity perspective

PubMed Central

Urban, Mark C; De Meester, Luc; Vellend, Mark; Stoks, Robby; Vanoverbeke, Joost

2012-01-01

We need to understand joint ecological and evolutionary responses to climate change to predict future threats to biological diversity. The ‘evolving metacommunity’ framework emphasizes that interactions between ecological and evolutionary mechanisms at both local and regional scales will drive community dynamics during climate change. Theory suggests that ecological and evolutionary dynamics often interact to produce outcomes different from those predicted based on either mechanism alone. We highlight two of these dynamics: (i) species interactions prevent adaptation of nonresident species to new niches and (ii) resident species adapt to changing climates and thereby prevent colonization by nonresident species. The rate of environmental change, level of genetic variation, source-sink structure, and dispersal rates mediate between these potential outcomes. Future models should evaluate multiple species, species interactions other than competition, and multiple traits. Future experiments should manipulate factors such as genetic variation and dispersal to determine their joint effects on responses to climate change. Currently, we know much more about how climates will change across the globe than about how species will respond to these changes despite the profound effects these changes will have on global biological diversity. Integrating evolving metacommunity perspectives into climate change biology should produce more accurate predictions about future changes to species distributions and extinction threats. PMID:25568038

The Economic Impact on Future European Security.

DTIC Science & Technology

1991-07-01

countries in the developing tripolar scenario, I purposely focused this discussion on economics within the realm of Europe with some consideration of...security definitions of a bipolar world to a world of what some would like to consider as multipolar, but is actually evolving into a tripolar world of U.S...Europe-Japan based on economic security.1 In his article describing the new tripolar world, Mr. Bergsten quotes historian Robert Gilpin’s statement

MSFC Skylab experimenter's reference

NASA Technical Reports Server (NTRS)

1974-01-01

The methods and techniques for experiment development and integration that evolved during the Skylab Program are described to facilitate transferring this experience to experimenters in future manned space programs. Management responsibilities and the sequential process of experiment evolution from initial concept through definition, development, integration, operation and postflight analysis are outlined in the main text and amplified, as appropriate, in appendixes. Emphasis is placed on specific lessons learned on Skylab that are worthy of consideration by future programs.

A Research Practitioner's Perspective on Culturally Relevant Prevention: Scientific and Practical Considerations for Community-Based Programs

ERIC Educational Resources Information Center

Griffin, James P., Jr.; Miller, Erica

2007-01-01

This article is a response to a number of articles that use a culturally relevant prevention (CRP) approach for ethnic and racial minorities. The reaction is from a research practitioner's viewpoint. The authors argue in favor of determining an operational definition of cultural relevance by implementing prevention services with fidelity in the…

Humanizing Pedagogy through HIV and AIDS Prevention: Transforming Teacher Knowledge. Series in Critical Narrative

ERIC Educational Resources Information Center

Paradigm Publishers, 2006

2006-01-01

This book explores the power of educators to serve as HIV and AIDS prevention agents. The definitive text represents the work of a distinguished panel of teacher educators and health scientists who identify core information and skills effective educators of HIV and AIDS prevention should learn as they prepare to attend to the academic and human…

Stalking and Cyberstalking. Prevention Update

ERIC Educational Resources Information Center

Higher Education Center for Alcohol, Drug Abuse, and Violence Prevention, 2011

2011-01-01

According to the Stalking Resource Center (SRC), "While legal definitions of stalking vary from one jurisdiction to another, a good working definition of stalking is a course of conduct directed at a specific person that would cause a reasonable person to feel fear. Stalking is serious, often violent, and can escalate over time." "Model Campus…

78 FR 56236 - Proposed Information Collection Activity; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2013-09-12

... accounting method used to report expenditures made in a fiscal year and monitor cumulative expenditures by... that the new categories listed on the ACF-196R would require; (f) whether definitions for categories are clear, or whether any of the definitions should be revised to prevent confusion over how to report...

76 FR 80747 - Approval and Promulgation of Implementation Plans; Oregon: New Source Review/Prevention of...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-27

... 340-228--Requirements for Fuel Burning Equipment and Fuel Sulfur Content 0020 Definitions 11/8/2007 0200 General Emission Standards for Fuel 11/8/2007 Burning Equipment, Sulfur Dioxide Standards. 0210... reduced sulfur (TRS) emission-related definitions. 0100 Wigwam Waste Burners, Wigwam Waste Burners 11/8...

76 FR 34996 - Proposed Data Collections Submitted for Public Comment and Recommendations

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-15

... categories of residential care facilities within each state that meet the NSLTCP definition and (2) for each... which the agency is responsible. The NSLTCP study definition of a residential care facility is one that..., Office of the Chief Science Officer, Centers for Disease Control and Prevention. [FR Doc. 2011-14791...

Healthcare-associated infection surveillance and bedside alerts.

PubMed

Adlassnig, Klaus-Peter; Berger, Angelika; Koller, Walter; Blacky, Alexander; Mandl, Harald; Unterasinger, Lukas; Rappelsberger, Andrea

2014-01-01

Expectations and requirements concerning the identification and surveillance of healthcare-associated infections (HAIs) are increasing, calling for differentiated automated approaches. In an attempt to bridge the "definition swamp" of these infections and serve the needs of different users, we improved the monitoring of nosocomial infections (MONI) software to create better surveillance reports according to consented national and international definitions, as well as produce infection overviews on complex clinical matters including alerts for the clinician's ward and bedside work. MONI contains and processes surveillance definitions for intensive-care-unit-acquired infections from the European Centre for Disease Prevention and Control, Sweden, as well as the Centers for Disease Control and Prevention, USA. The latest release of MONI also includes KISS criteria of the German National Reference Center for Surveillance of Nosocomial Infections. In addition to these "classic" surveillance criteria, clinical alert criteria--which are similar but not identical to the surveillance criteria--were established together with intensivists. This is an important step to support both infection control and clinical personnel; and--last but not least--to foster co-evolution of the two groups of definitions: surveillance and alerts.

[Child abuse: a world problem].

PubMed

Santana-Tavira, R; Sánchez-Ahedo, R; Herrera-Basto, E

1998-01-01

Several problems are encountered in the study of child abuse: ignorance of its real proportions, deep cultural and historical roots, diversity of opinion as to its definition and classification and, finally, very diverse considerations on its repercussions and therapeutic management. The present study approaches child abuse from its historical precedents, its classifications, definitions and epidemiology. In addition, repercussions are reviewed, and treatment alternatives considered which are held as fundamental to confront this alarmingly increasing phenomenon. It is important to unify criteria as to the definition and classification of scientific information surrounding demographic data which, in the end, will situate the problem, the progress related to its causes, diagnosis, preventive measures and treatment. It is extremely important to prevent child abuse by all possible means, since this harm is reflected in the adult life of the child. Various classifications are considered, as well as characteristics of the abuser and of the abused.

Proposed Standardized Neurological Endpoints for Cardiovascular Clinical Trials: An Academic Research Consortium Initiative.

PubMed

Lansky, Alexandra J; Messé, Steven R; Brickman, Adam M; Dwyer, Michael; Bart van der Worp, H; Lazar, Ronald M; Pietras, Cody G; Abrams, Kevin J; McFadden, Eugene; Petersen, Nils H; Browndyke, Jeffrey; Prendergast, Bernard; Ng, Vivian G; Cutlip, Donald E; Kapadia, Samir; Krucoff, Mitchell W; Linke, Axel; Scala Moy, Claudia; Schofer, Joachim; van Es, Gerrit-Anne; Virmani, Renu; Popma, Jeffrey; Parides, Michael K; Kodali, Susheel; Bilello, Michel; Zivadinov, Robert; Akar, Joseph; Furie, Karen L; Gress, Daryl; Voros, Szilard; Moses, Jeffrey; Greer, David; Forrest, John K; Holmes, David; Kappetein, Arie P; Mack, Michael; Baumbach, Andreas

2018-05-14

Surgical and catheter-based cardiovascular procedures and adjunctive pharmacology have an inherent risk of neurological complications. The current diversity of neurological endpoint definitions and ascertainment methods in clinical trials has led to uncertainties in the neurological risk attributable to cardiovascular procedures and inconsistent evaluation of therapies intended to prevent or mitigate neurological injury. Benefit-risk assessment of such procedures should be on the basis of an evaluation of well-defined neurological outcomes that are ascertained with consistent methods and capture the full spectrum of neurovascular injury and its clinical effect. The Neurologic Academic Research Consortium is an international collaboration intended to establish consensus on the definition, classification, and assessment of neurological endpoints applicable to clinical trials of a broad range of cardiovascular interventions. Systematic application of the proposed definitions and assessments will improve our ability to evaluate the risks of cardiovascular procedures and the safety and effectiveness of preventive therapies.

Opportunities to meet challenges in rural prevention research: findings from an evolving community-university partnership model.

PubMed

Spoth, Richard

2007-01-01

Various rural prevention research challenges have been articulated through a series of sessions convened since the mid 1990s by the National Institutes of Health, particularly the National Institute on Drug Abuse. Salient in this articulation was the need for effective collaboration among rural practitioners and scientists, with special consideration of accommodating the diversity of rural areas and surmounting barriers to implementation of evidence-based interventions. This paper summarizes the range of challenges in rural prevention research and describes an evolving community-university partnership model addressing them. The model entails involvement of public school staff and other rural community stakeholders, linked with scientists by Land Grant University-based Extension system staff. Examples of findings from over 16 years of partnership-based intervention research projects include those on engagement of rural residents, quality implementation of evidence-based interventions, and long-term community-level outcomes, as well as factors in effectiveness of the partnerships. Findings suggest a future focus on building capacity for practitioner-scientist collaboration and developing a network for more widespread implementation of the partnership model in a manner informed by lessons learned from partnership-based research to date.

30 CFR 700.5 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-07-01

... substantial physical harm to persons, property, or the environment and to which persons or improvements on... substantially the quality of the environment, prevent or damage the beneficial use of land or water resources.... Reclamation activity means the reclamation, abatement, control, or prevention of adverse effects of past...

30 CFR 700.5 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-07-01

... substantial physical harm to persons, property, or the environment and to which persons or improvements on... substantially the quality of the environment, prevent or damage the beneficial use of land or water resources.... Reclamation activity means the reclamation, abatement, control, or prevention of adverse effects of past...

33 CFR 155.200 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-07-01

....200 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) POLLUTION OIL OR HAZARDOUS MATERIAL POLLUTION PREVENTION REGULATIONS FOR VESSELS Vessel Equipment § 155.200...-5, 46 CFR 70.05-30, or 46 CFR 90.05-35 or pursuant to an International Oil Pollution Prevention...

Stress and Burnout: An Organizational Synthesis.

ERIC Educational Resources Information Center

McLean, Leslie H.; Clouse, R. Wilburn

In the care, prevention, and treatment, of burnout, the reoccurring theme is "control and balance" between expectation and performance. Burnout is treatable and preventable, but changes and interventions must occur on all levels, (individual, organizational, and societal). Recent research, which has expanded the already complex definition of…

33 CFR 155.200 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-07-01

....200 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) POLLUTION OIL OR HAZARDOUS MATERIAL POLLUTION PREVENTION REGULATIONS FOR VESSELS Vessel Equipment § 155.200...-5, 46 CFR 70.05-30, or 46 CFR 90.05-35 or pursuant to an International Oil Pollution Prevention...

33 CFR 155.200 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-07-01

....200 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) POLLUTION OIL OR HAZARDOUS MATERIAL POLLUTION PREVENTION REGULATIONS FOR VESSELS Vessel Equipment § 155.200...-5, 46 CFR 70.05-30, or 46 CFR 90.05-35 or pursuant to an International Oil Pollution Prevention...

33 CFR 155.200 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-07-01

....200 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) POLLUTION OIL OR HAZARDOUS MATERIAL POLLUTION PREVENTION REGULATIONS FOR VESSELS Vessel Equipment § 155.200...-5, 46 CFR 70.05-30, or 46 CFR 90.05-35 or pursuant to an International Oil Pollution Prevention...

33 CFR 155.200 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-07-01

....200 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) POLLUTION OIL OR HAZARDOUS MATERIAL POLLUTION PREVENTION REGULATIONS FOR VESSELS Vessel Equipment § 155.200...-5, 46 CFR 70.05-30, or 46 CFR 90.05-35 or pursuant to an International Oil Pollution Prevention...

New Perspectives on Dry Eye Definition and Diagnosis: A Consensus Report by the Asia Dry Eye Society.

PubMed

Tsubota, Kazuo; Yokoi, Norihiko; Shimazaki, Jun; Watanabe, Hitoshi; Dogru, Murat; Yamada, Masakazu; Kinoshita, Shigeru; Kim, Hyo-Myung; Tchah, Hung-Won; Hyon, Joon Young; Yoon, Kyung-Chul; Seo, Kyoung Yul; Sun, Xuguang; Chen, Wei; Liang, Lingyi; Li, Mingwu; Liu, Zuguo

2017-01-01

For the last 20 years, a great amount of evidence has accumulated through epidemiological studies that most of the dry eye disease encountered in daily life, especially in video display terminal (VDT) workers, involves short tear film breakup time (TFBUT) type dry eye, a category characterized by severe symptoms but minimal clinical signs other than short TFBUT. An unstable tear film also affects the visual function, possibly due to the increase of higher order aberrations. Based on the change in the understanding of the types, symptoms, and signs of dry eye disease, the Asia Dry Eye Society agreed to the following definition of dry eye: "Dry eye is a multifactorial disease characterized by unstable tear film causing a variety of symptoms and/or visual impairment, potentially accompanied by ocular surface damage." The definition stresses instability of the tear film as well as the importance of visual impairment, highlighting an essential role for TFBUT assessment. This paper discusses the concept of Tear Film Oriented Therapy (TFOT), which evolved from the definition of dry eye, emphasizing the importance of a stable tear film. Copyright © 2016 The Author(s). Published by Elsevier Inc. All rights reserved.

The definition of community integration: perspectives of people with brain injuries.

PubMed

McColl, M A; Carlson, P; Johnston, J; Minnes, P; Shue, K; Davies, D; Karlovits, T

1998-01-01

Despite considerable attention to community integration and related topics in the past decades, a clear definition of community integration continues to elude researchers and service providers. Common to most discussions of the topic, however, are three ideas: that integration involves relationships with others, independence in one's living situation and activities to fill one's time. The present study sought to expand this conceptualization of community integration by asking people with brain injuries for their own perspectives on community integration. This qualitative study resulted in a definition of community integration consisting of nine indicators: orientation, acceptance, conformity, close and diffuse relationships, living situation, independence, productivity and leisure. These indicators were empirically derived from the text of 116 interviews with people with moderate-severe brain injuries living in the community. Eighteen adults living in supported living programmes were followed for 1 year, to track their evolving definition of integration and the factors they felt were related to integration. The study also showed a general trend toward more positive evaluation over the year, and revealed that positive evaluation was frequently related to meeting new people and freedom from staff supervision. These findings are interpreted in the light of recommendations for community programmes.

A summary of the new GINA strategy: a roadmap to asthma control

PubMed Central

Bateman, Eric D.; Becker, Allan; Boulet, Louis-Philippe; Cruz, Alvaro A.; Drazen, Jeffrey M.; Haahtela, Tari; Hurd, Suzanne S.; Inoue, Hiromasa; de Jongste, Johan C.; Lemanske, Robert F.; Levy, Mark L.; O'Byrne, Paul M.; Paggiaro, Pierluigi; Pedersen, Soren E.; Pizzichini, Emilio; Soto-Quiroz, Manuel; Szefler, Stanley J.; Wong, Gary W.K.; FitzGerald, J. Mark

2015-01-01

Over the past 20 years, the Global Initiative for Asthma (GINA) has regularly published and annually updated a global strategy for asthma management and prevention that has formed the basis for many national guidelines. However, uptake of existing guidelines is poor. A major revision of the GINA report was published in 2014, and updated in 2015, reflecting an evolving understanding of heterogeneous airways disease, a broader evidence base, increasing interest in targeted treatment, and evidence about effective implementation approaches. During development of the report, the clinical utility of recommendations and strategies for their practical implementation were considered in parallel with the scientific evidence. This article provides a summary of key changes in the GINA report, and their rationale. The changes include a revised asthma definition; tools for assessing symptom control and risk factors for adverse outcomes; expanded indications for inhaled corticosteroid therapy; a framework for targeted treatment based on phenotype, modifiable risk factors, patient preference, and practical issues; optimisation of medication effectiveness by addressing inhaler technique and adherence; revised recommendations about written asthma action plans; diagnosis and initial treatment of the asthma−chronic obstructive pulmonary disease overlap syndrome; diagnosis in wheezing pre-school children; and updated strategies for adaptation and implementation of GINA recommendations. PMID:26206872

Positive Healthy Organizations: Promoting Well-Being, Meaningfulness, and Sustainability in Organizations

PubMed Central

Di Fabio, Annamaria

2017-01-01

This contribution deals with the concept of healthy organizations and starts with a definition of healthy organizations and healthy business. In healthy organizations, culture, climate, and practices create an environment conducive to employee health and safety as well as organizational effectiveness (Lowe, 2010). A healthy organization thus leads to a healthy and successful business (De Smet et al., 2007; Grawitch and Ballard, 2016), underlining the strong link between organizational profitability and workers’ well-being. Starting from a positive perspective focused on success and excellence, the contribution describes how positive organizational health psychology evolved from occupational health psychology to positive occupational health psychology stressing the importance of a primary preventive approach. The focus is not on deficiency and failure but on a positive organizational attitude that proposes interventions at different levels: individual, group, organization, and inter-organization. Healthy organizations need to find the right balance between their particular situation, sector, and culture, highlighting the importance of well-being and sustainability. This contribution discusses also the sustainability of work-life projects and the meaning of work in healthy organizations, stressing the importance of recognizing, respecting, and using the meaning of work as a key for growth and success. Finally, the contribution discusses new research and intervention opportunities for healthy organizations. PMID:29184517

The Evolving Role of Multivitamin/Multimineral Supplement Use among Adults in the Age of Personalized Nutrition

PubMed Central

Sesso, Howard D.; Ulrich, Cornelia M.

2018-01-01

Micronutrient deficiencies occur in segments of the adult population in the United States. Multivitamin/multimineral supplements (MVMS) are widely used by this population, which reduces inadequacies in micronutrient intake, but the potential for exceeding tolerable upper intake levels in others should be considered. There are concerns associated with the excessive intake of certain nutrients, particularly folic acid, and potential untoward consequences. The advent of nutrigenomics and the enhanced ability to directly study the interactions between nutrition and genetic variants and expression will allow for the conduct of more targeted studies with specific endpoints and may ultimately lead to progress in the field of personalized nutrition. The role of MVMS in health maintenance and chronic disease prevention remains controversial. Conducting studies in this area has been hampered by, among other factors, inconsistent definitions of MVMS, ranging from as few as three vitamins to broad-spectrum products containing more than two dozen vitamins and minerals. Results from some observational studies and large-scale, randomized, controlled trials suggest that MVMS may reduce the risk of some forms of cancer and, potentially, cardiovascular disease. The ongoing COcoa Supplement and Multivitamin Outcomes Study (COSMOS) is expected to build on this research and provide additional insights into these areas. PMID:29470410

Plasmids in Gram negatives: molecular typing of resistance plasmids.

PubMed

Carattoli, Alessandra

2011-12-01

A plasmid is defined as a double stranded, circular DNA molecule capable of autonomous replication. By definition, plasmids do not carry genes essential for the growth of host cells under non-stressed conditions but they have systems which guarantee their autonomous replication also controlling the copy number and ensuring stable inheritance during cell division. Most of the plasmids confer positively selectable phenotypes by the presence of antimicrobial resistance genes. Plasmids evolve as an integral part of the bacterial genome, providing resistance genes that can be easily exchanged among bacteria of different origin and source by conjugation. A multidisciplinary approach is currently applied to study the acquisition and spread of antimicrobial resistance in clinically relevant bacterial pathogens and the established surveillance can be implemented by replicon typing of plasmids. Particular plasmid families are more frequently detected among Enterobacteriaceae and play a major role in the diffusion of specific resistance genes. For instance, IncFII, IncA/C, IncL/M, IncN and IncI1 plasmids carrying extended-spectrum beta-lactamase genes and acquired AmpC genes are currently considered to be "epidemic resistance plasmids", being worldwide detected in Enterobacteriaceae of different origin and sources. The recognition of successful plasmids is an essential first step to design intervention strategies preventing their spread. Copyright © 2011 Elsevier GmbH. All rights reserved.

Positive Healthy Organizations: Promoting Well-Being, Meaningfulness, and Sustainability in Organizations.

PubMed

Di Fabio, Annamaria

2017-01-01

This contribution deals with the concept of healthy organizations and starts with a definition of healthy organizations and healthy business. In healthy organizations, culture, climate, and practices create an environment conducive to employee health and safety as well as organizational effectiveness (Lowe, 2010). A healthy organization thus leads to a healthy and successful business (De Smet et al., 2007; Grawitch and Ballard, 2016), underlining the strong link between organizational profitability and workers' well-being. Starting from a positive perspective focused on success and excellence, the contribution describes how positive organizational health psychology evolved from occupational health psychology to positive occupational health psychology stressing the importance of a primary preventive approach. The focus is not on deficiency and failure but on a positive organizational attitude that proposes interventions at different levels: individual, group, organization, and inter-organization. Healthy organizations need to find the right balance between their particular situation, sector, and culture, highlighting the importance of well-being and sustainability. This contribution discusses also the sustainability of work-life projects and the meaning of work in healthy organizations, stressing the importance of recognizing, respecting, and using the meaning of work as a key for growth and success. Finally, the contribution discusses new research and intervention opportunities for healthy organizations.

Investigating HIV Infection and HIV Incidence Among Chinese Men Who Have Sex with Men with Recent Sexual Debut, Chongqing, China, 2011.

PubMed

Wang, Na; Wu, Guohui; Lu, Rongrong; Feng, Liangui; Xiao, Yan; McFarland, Willi; Ruan, Yuhua; Shao, Yiming; Raymond, H F

2016-12-01

HIV among men who have sex with men (MSM) with recent male-male sexual debut, such as within the past 5 years, may be a proxy for recent HIV infection. Using this definition, we explored factors associated with HIV infection in this group to understand the evolving HIV epidemic among MSM in Chongqing. We conducted a cross-sectional respondent-driven sampling survey among Chongqing MSM in 2011. Computer-assisted, self-administered questionnaires were used and blood specimens were collected for HIV and syphilis testing. Three hundred and ninety-one unique MSM were recruited of which 65.7 % (257) had their sexual debut with another man in the past 5 years. HIV prevalence among men with recent sexual debut was 18.7 % suggesting a possible HIV incidence of 3.7 %. Multivariable analysis among men with recent sexual debut suggests that lower education, having more than one male partner, and currently being infected with syphilis are associated with HIV among men with recent sexual debut. HIV prevalence is high among MSM with recent sexual debut in Chongqing, which may be a proxy a high incidence rate. HIV prevention efforts should focus on STD reduction among those MSM with lower educational attainment.

Assessment and classification of patients with myocardial injury and infarction in clinical practice

PubMed Central

Chapman, Andrew R; Adamson, Philip D

2017-01-01

Myocardial injury is common in patients without acute coronary syndrome, and international guidelines recommend patients with myocardial infarction are classified by aetiology. The universal definition differentiates patients with myocardial infarction due to plaque rupture (type 1) from those due to myocardial oxygen supply-demand imbalance (type 2) secondary to other acute illnesses. Patients with myocardial necrosis, but no symptoms or signs of myocardial ischaemia, are classified as acute or chronic myocardial injury. This classification has not been widely adopted in practice, because the diagnostic criteria for type 2 myocardial infarction encompass a wide range of presentations, and the implications of the diagnosis are uncertain. However, both myocardial injury and type 2 myocardial infarction are common, occurring in more than one-third of all hospitalised patients. These patients have poor short-term and long-term outcomes with two-thirds dead in 5 years. The classification of patients with myocardial infarction continues to evolve, and future guidelines are likely to recognise the importance of identifying coronary artery disease in type 2 myocardial infarction. Clinicians should consider whether coronary artery disease has contributed to myocardial injury, as selected patients are likely to benefit from further investigation and in these patients targeted secondary prevention has the potential to improve outcomes. PMID:27806987

Reporting Fatal Neglect in Child Death Review.

PubMed

Scott, Debbie

2018-01-01

Child death reviews are conducted with the aim of preventing child deaths however, definitions, inclusion criteria for the review of child deaths and reporting practices vary across Child Death Review Teams (CDRTs). This article aims to identify a common context and understanding of fatal neglect reporting by reviewing definitional issues of fatal neglect and comparing reporting practice across a number of CDRTs. Providing a consistent context for identifying and reporting neglect-related deaths may improve the understanding of the impact of fatal neglect and the risk factors associated with it and therefore, improve the potential of CDRT review to inform prevention programs, policies, and procedures.

The burden of proof: The current state of atrial fibrillation prevention and treatment trials.

PubMed

Zakeri, Rosita; Van Wagoner, David R; Calkins, Hugh; Wong, Tom; Ross, Heather M; Heist, E Kevin; Meyer, Timothy E; Kowey, Peter R; Mentz, Robert J; Cleland, John G; Pitt, Bertram; Zannad, Faiez; Linde, Cecilia

2017-05-01

Atrial fibrillation (AF) is an age-related arrhythmia of enormous socioeconomic significance. In recent years, our understanding of the basic mechanisms that initiate and perpetuate AF has evolved rapidly, catheter ablation of AF has progressed from concept to reality, and recent studies suggest lifestyle modification may help prevent AF recurrence. Emerging developments in genetics, imaging, and informatics also present new opportunities for personalized care. However, considerable challenges remain. These include a paucity of studies examining AF prevention, modest efficacy of existing antiarrhythmic therapies, diverse ablation technologies and practice, and limited evidence to guide management of high-risk patients with multiple comorbidities. Studies examining the long-term effects of AF catheter ablation on morbidity and mortality outcomes are not yet completed. In many ways, further progress in the field is heavily contingent on the feasibility, capacity, and efficiency of clinical trials to incorporate the rapidly evolving knowledge base and to provide substantive evidence for novel AF therapeutic strategies. This review outlines the current state of AF prevention and treatment trials, including the foreseeable challenges, as discussed by a unique forum of clinical trialists, scientists, and regulatory representatives in a session endorsed by the Heart Rhythm Society at the 12th Global CardioVascular Clinical Trialists Forum in Washington, DC, December 3-5, 2015. Copyright © 2017 Heart Rhythm Society. Published by Elsevier Inc. All rights reserved.

Self-reported concussion history: impact of providing a definition of concussion.

PubMed

Robbins, Clifford A; Daneshvar, Daniel H; Picano, John D; Gavett, Brandon E; Baugh, Christine M; Riley, David O; Nowinski, Christopher J; McKee, Ann C; Cantu, Robert C; Stern, Robert A

2014-01-01

In recent years, the understanding of concussion has evolved in the research and medical communities to include more subtle and transient symptoms. The accepted definition of concussion in these communities has reflected this change. However, it is unclear whether this shift is also reflected in the understanding of the athletic community. Self-reported concussion history is an inaccurate assessment of someone's lifetime exposure to concussive brain trauma. However, unfortunately, in many cases it is the only available tool. We hypothesize that athletes' self-reported concussion histories will be significantly greater after reading them the current definition of concussion, relative to the reporting when no definition was provided. An increase from baseline to post-definition response will suggest that athletes are unaware of the currently accepted medical definition. Cross-sectional study of 472 current and former athletes. Investigators conducted structured telephone interviews with current and former athletes between January 2010 and January 2013, asking participants to report how many concussions they had received in their lives. Interviewers then read participants a current definition of concussion, and asked them to re-estimate based on that definition. THE TWO ESTIMATES WERE SIGNIFICANTLY DIFFERENT (WILCOXON SIGNED RANK TEST: z=15.636, P<0.001). Comparison of the baseline and post-definition medians (7 and 15, respectively) indicated that the post-definition estimate was approximately twice the baseline. Follow-up analyses indicated that this effect was consistent across all levels of competition examined and across type of sport (contact versus non-contact). Our results indicate that athletes' current understandings of concussions are not consistent with a currently accepted medical definition. We strongly recommend that clinicians and researchers preface requests for self-reported concussion history with a definition. In addition, it is extremely important that researchers report the definition they used in published manuscripts of their work. Our study shows that unprompted reporting of concussion history produces results that are significantly different from those provided after a definition has been given, suggesting one possible mechanism to improve the reliability of self-reported concussion history across multiple individuals.

"What do you think of when I say the word 'snack'?" Towards a cohesive definition among low-income caregivers of preschool-age children.

PubMed

Younginer, Nicholas A; Blake, Christine E; Davison, Kirsten K; Blaine, Rachel E; Ganter, Claudia; Orloski, Alexandria; Fisher, Jennifer Orlet

2016-03-01

Despite agreement that snacks contribute significant energy to children's diets, evidence of the effects of snacks on health, especially in children, is weak. Some of the lack of consistent evidence may be due to a non-standardized definition of snacks. Understanding how caregivers of preschool-aged children conceptualize and define child snacks could provide valuable insights on epidemiological findings, targets for anticipatory guidance, and prevention efforts. Participants were 59 ethnically-diverse (White, Hispanic, and African American), low-income urban caregivers of children age 3-5 years. Each caregiver completed a 60-90 min semi-structured in-depth interview to elicit their definitions of child snacks. Data were coded by two trained coders using theoretically-guided emergent coding techniques to derive key dimensions of caregivers' child snack definitions. Five interrelated dimensions of a child snack definition were identified: (1) types of food, (2) portion size, (3) time, (4) location, and (5) purpose. Based on these dimensions, an empirically-derived definition of caregivers' perceptions of child snacks is offered: A small portion of food that is given in-between meals, frequently with an intention of reducing or preventing hunger until the next mealtime. These findings suggest interrelated dimensions that capture the types of foods and eating episodes that are defined as snacks. Child nutrition studies and interventions that include a focus on child snacks should consider using an a priori multi-dimensional definition of child snacks. Copyright © 2015 Elsevier Ltd. All rights reserved.

Gut instinct.

PubMed

Bion, Julian

2013-12-19

Barriers to the use of selective digestive decontamination include concerns about emergence of resistant organisms, over-estimation of current performance in preventing ventilator-associated pneumonia (VAP), alternative methods of preventing VAP, and misunderstanding of mechanisms of action. A definitive cluster-randomised trial should be undertaken that incorporates practitioner concerns and effect-size preferences.

Toward an Integrated Theory of Relational Youth Violence: Bridging a Gap among the Theory, Research, and Practice of Bullying Prevention

ERIC Educational Resources Information Center

Brion-Meisels, Gretchen; Garnett, Bernice Raveche

2016-01-01

Despite an increased interest in bullying prevention programming over the last 10 years, significant gaps remain among theory, research, and practice in this critical area of school psychology. This article argues that the current Centers for Disease Control and Prevention (CDC) definition of bullying does not fully capture the experiences of many…

20 CFR 655.302 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-04-01

... Nurses § 655.302 Definitions. For the purposes of subparts D and E of this part: Accepted for filing.... Bona fide medical emergency means a situation in which the services of one or more H-1A contract nurses are necessary at a worksite facility (which itself does not employ an H-1A nurse) to prevent death or...

75 FR 43892 - Approval and Promulgation of Implementation Plans; New York Prevention of Significant...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-27

... proposal related to the Tailoring Rule thresholds. III. What is EPA's analysis of New York's NSR rule...) Program. New York's amendments to Part 201 revise the definition for ``major stationary source or major... Parts 200 and 201, including the new or revised definitions are consistent with Federal guidance, EPA is...

Introducing the CERT (Trademark) Resiliency Engineering Framework: Improving the Security and Sustainability Processes

DTIC Science & Technology

2007-05-01

Organizational Structure 40 6.1.3 Funding Model 40 6.1.4 Role of Information Technology 40 6.2 Considering Process Improvement 41 6.2.1 Dimensions of...to the process definition for resiliency engineering. 6.1.3 Funding Model Just as organizational structures tend to align across security and...responsibility. Adopting an enter- prise view of operational resiliency and a process improvement approach requires that the funding model evolve to one

Muzzling the Bear: Gorbachev’s Program to Restructure the Soviet Military

DTIC Science & Technology

1990-04-01

quantity to quality- in a continuing program of military accumulation.4 4 Steven Adragna argues thalt Soviet military doctrine can not evolve until it...aggressive nature and intent of capitalist society. Adragna maintains that so far there has been no serious effort to discredit the historical theorem that...any military action the Soviet Union takes is defensive in nature by definition and is therefore justified. Further, Adragna claims that the Kremlin’s

Indian Family Exception Doctrine: still losing children despite the Indian Child Welfare Act.

PubMed

Cross, Suzanne L

2006-01-01

Since 1982, the Indian Family Exception Doctrine has been circumventing the Indian Child Welfare Act of 1978. Although not clearly defined, the doctrine has been pivotal in several American Indian child welfare cases in the United States. Over time, the doctrine continues to evolve and self-define. Several phrases have become part of the definition, such as Indian family and culture. This doctrine presents major concerns and implications in the field of child welfare.

How semantic category modulates preschool children's visual memory.

PubMed

Giganti, Fiorenza; Viggiano, Maria Pia

2015-01-01

The dynamic interplay between perception and memory has been explored in preschool children by presenting filtered stimuli regarding animals and artifacts. The identification of filtered images was markedly influenced by both prior exposure and the semantic nature of the stimuli. The identification of animals required less physical information than artifacts did. Our results corroborate the notion that the human attention system evolves to reliably develop definite category-specific selection criteria by which living entities are monitored in different ways.

Clinical Pharmacology & Therapeutics: Past, Present and Future

PubMed Central

Waldman, SA; Terzic, A

2016-01-01

Clinical Pharmacology & Therapeutics (CPT), the definitive and timely source for advances in human therapeutics, transcends the drug discovery, development, regulation and utilization continuum to catalyze, evolve and disseminate discipline-transformative knowledge. Prioritized themes and multidisciplinary content drive the science and practice of clinical pharmacology, offering a trusted point of reference. An authoritative herald across global communities, CPT is a timeless information vehicle at the vanguard of discovery, translation and application ushering therapeutic innovation into modern health care. PMID:28194770

Detection and Prevention of Learning Disorders.

ERIC Educational Resources Information Center

Yahraes, Herbert; Prestwich, Sherry

The document provides an overview of learning disabilities and described are various approaches to the detection and prevention of these handicapping conditions. Discussed in the introduction are definitions of learning disorders, the multiple nature of the handicap, and maturational lag as a cause. A section on clinical approaches covers research…

28 CFR 18.3 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-07-01

... Justice Act means the Juvenile Justice and Delinquency Prevention Act of 1974, 42 U.S.C. 5601, et seq., as... Juvenile Justice and Delinquency Prevention (OJJDP), as appropriate. (i) Sub-grant applicant or recipient... provisions of part D of the Crime Control Act; part B, subpart I of the Juvenile Justice Act; and sections...

28 CFR 18.3 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-07-01

... Justice Act means the Juvenile Justice and Delinquency Prevention Act of 1974, 42 U.S.C. 5601, et seq., as... Juvenile Justice and Delinquency Prevention (OJJDP), as appropriate. (i) Sub-grant applicant or recipient... provisions of part D of the Crime Control Act; part B, subpart I of the Juvenile Justice Act; and sections...

Advanced missions safety. Volume 3: Appendices. Part 2: Experiment

NASA Technical Reports Server (NTRS)

Hinton, M. G., Jr.

1972-01-01

Supporting documentation pertaining to the hazards of transporting experimental equipment on the Earth Orbit Shuttle is presented. The subjects discussed are: (1) experiment and hardware definition, (2) hazard analysis, (3) preventive measure assessment, (4) preventive measures statements, (5) remedial measure assessment, and (6) experiment interaction safety considerations.

78 FR 20411 - Supplemental Nutrition Assistance Program: Nutrition Education and Obesity Prevention Grant Program

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-05

..., multi- level interventions; and community and public health approaches. To improve program design... prevention services and an evidence-based approach are provided for States to use in their SNAP-Ed programming. These definitions provide States with greater flexibility to include environmental approaches and...

28 CFR 18.3 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-07-01

... Justice Act means the Juvenile Justice and Delinquency Prevention Act of 1974, 42 U.S.C. 5601, et seq., as... Juvenile Justice and Delinquency Prevention (OJJDP), as appropriate. (i) Sub-grant applicant or recipient... provisions of part D of the Crime Control Act; part B, subpart I of the Juvenile Justice Act; and sections...

28 CFR 18.3 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-07-01

... Justice Act means the Juvenile Justice and Delinquency Prevention Act of 1974, 42 U.S.C. 5601, et seq., as... Juvenile Justice and Delinquency Prevention (OJJDP), as appropriate. (i) Sub-grant applicant or recipient... provisions of part D of the Crime Control Act; part B, subpart I of the Juvenile Justice Act; and sections...

40 CFR 721.3 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-07-01

... concentration in air at 0.5 milligrams or less per liter of air (LC50). CAS Number means Chemical Abstracts..., trade name, brand name, or generic chemical name used to identify a chemical substance other than by its... Office of Pollution Prevention and Toxics means the Director of the EPA Office of Pollution Prevention...

40 CFR 721.3 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-07-01

... concentration in air at 0.5 milligrams or less per liter of air (LC50). CAS Number means Chemical Abstracts..., trade name, brand name, or generic chemical name used to identify a chemical substance other than by its... Office of Pollution Prevention and Toxics means the Director of the EPA Office of Pollution Prevention...

40 CFR 721.3 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-07-01

... concentration in air at 0.5 milligrams or less per liter of air (LC50). CAS Number means Chemical Abstracts..., trade name, brand name, or generic chemical name used to identify a chemical substance other than by its... Office of Pollution Prevention and Toxics means the Director of the EPA Office of Pollution Prevention...

40 CFR 721.3 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-07-01

... concentration in air at 0.5 milligrams or less per liter of air (LC50). CAS Number means Chemical Abstracts..., trade name, brand name, or generic chemical name used to identify a chemical substance other than by its... Office of Pollution Prevention and Toxics means the Director of the EPA Office of Pollution Prevention...

Pharmaceutical Care and the Role of a Pharmacist in Space Medicine

NASA Technical Reports Server (NTRS)

Bayuse, Tina

2007-01-01

Space medicine is primarily preventative medicine Outcomes of space medicine pharmaceutical care are: a) Elimination or reduction of a patient's symptomatology; b) Arresting or slowing of long term effects from microgravity; and c) Preventing long term effects or symptomatology as a result of microgravity. Space medicine pharmaceutical care is about both the patient and the mission. Pharmaceutical care in the area of space medicine is evolving. A pharmacist serves a critical role in this care. Commercial space travel will require pharmacist involvement.

Preclinical diagnosis of Alzheimer’s disease: Prevention or prediction?

PubMed Central

Nitrini, Ricardo

2010-01-01

The diagnosis of Alzheimer’s disease (AD) for cases with dementia may be too late to allow effective treatment. Criteria for diagnosis of preclinical AD suggested by the Alzheimer’s Association include the use of molecular and structural biomarkers. Preclinical diagnosis will enable testing of new drugs and forms of treatment toward achieving successful preventive treatment. But what are the advantages for the individual? To know that someone who is cognitively normal is probably going to develop AD’s dementia when there is no effective preventive treatment is definitely not good news. A research method whereby volunteers are assigned to receive treatment or placebo without knowing whether they are in the control or at-risk arm of a trial would overcome this potential problem. If these new criteria are used wisely they may represent a relevant milestone in the search for a definitive treatment for AD. PMID:29213696

Rapid evolution meets invasive species control: The potential for pesticide resistance in sea lamprey

USGS Publications Warehouse

Dunlop, Erin S.; McLaughlin, Robert L.; Adams, Jean V.; Jones, Michael L.; Birceanu, Oana; Christie, Mark R.; Criger, Lori A.; Hinderer, Julia L.M.; Hollingworth, Robert M.; Johnson, Nicholas; Lantz, Stephen R.; Li, Weiming; Miller, James R.; Morrison, Bruce J.; Mota-Sanchez, David; Muir, Andrew M.; Sepulveda, Maria S.; Steeves, Todd B.; Walter, Lisa; Westman, Erin; Wirgin, Isaac; Wilkie, Michael P.

2018-01-01

Rapid evolution of pest, pathogen and wildlife populations can have undesirable effects; for example, when insects evolve resistance to pesticides or fishes evolve smaller body size in response to harvest. A destructive invasive species in the Laurentian Great Lakes, the sea lamprey (Petromyzon marinus) has been controlled with the pesticide 3-trifluoromethyl-4-nitrophenol (TFM) since the 1950s. We evaluated the likelihood of sea lamprey evolving resistance to TFM by (1) reviewing sea lamprey life history and control; (2) identifying physiological and behavioural resistance strategies; (3) estimating the strength of selection from TFM; (4) assessing the timeline for evolution; and (5) analyzing historical toxicity data for evidence of resistance. The number of sea lamprey generations exposed to TFM was within the range observed for fish populations where rapid evolution has occurred. Mortality from TFM was estimated as 82-90%, suggesting significant selective pressure. However, 57 years of toxicity data revealed no increase in lethal concentrations of TFM. Vigilance and the development of alternative controls are required to prevent this aquatic invasive species from evolving strategies to evade control.

Intelligent Tutoring Systems: Past, Present, and Future.

DTIC Science & Technology

1994-05-01

prevent fnmration. 10 Our working definition of computer-tutor intelligence is that the system must behave intelligMtly, not actually be intelligent...e.g., Reiser, Ramey, Lovett & Kimberg, 1989), the student is not only prevented from following these mistakes to their logical conclusion (and getting...hopelessly confused) but also prevented from obtaining an insight into the mistake (i.e., that the mistake is obvious). These ae some of the best

The Epidemiology of Transfusion-related Acute Lung Injury Varies According to the Applied Definition of Lung Injury Onset Time.

PubMed

Vande Vusse, Lisa K; Caldwell, Ellen; Tran, Edward; Hogl, Laurie; Dinwiddie, Steven; López, José A; Maier, Ronald V; Watkins, Timothy R

2015-09-01

Research that applies an unreliable definition for transfusion-related acute lung injury (TRALI) may draw false conclusions about its risk factors and biology. The effectiveness of preventive strategies may decrease as a consequence. However, the reliability of the consensus TRALI definition is unknown. To prospectively study the effect of applying two plausible definitions of acute respiratory distress syndrome onset time on TRALI epidemiology. We studied 316 adults admitted to the intensive care unit and transfused red blood cells within 24 hours of blunt trauma. We identified patients with acute respiratory distress syndrome, and defined acute respiratory distress syndrome onset time two ways: (1) the time at which the first radiographic or oxygenation criterion was met, and (2) the time both criteria were met. We categorized two corresponding groups of TRALI cases transfused in the 6 hours before acute respiratory distress syndrome onset. We used Cohen's kappa to measure agreement between the TRALI cases and implicated blood components identified by the two acute respiratory distress syndrome onset time definitions. In a nested case-control study, we examined potential risk factors for each group of TRALI cases, including demographics, injury severity, and characteristics of blood components transfused in the 6 hours before acute respiratory distress syndrome onset. Forty-two of 113 patients with acute respiratory distress syndrome were TRALI cases per the first acute respiratory distress syndrome onset time definition and 63 per the second definition. There was slight agreement between the two groups of TRALI cases (κ = 0.16; 95% confidence interval, -0.01 to 0.33) and between the implicated blood components (κ = 0.15, 95% confidence interval, 0.11-0.20). Age, Injury Severity Score, high plasma-volume components, and transfused plasma volume were risk factors for TRALI when applying the second acute respiratory distress syndrome onset time definition but not when applying the first definition. The epidemiology of TRALI varies when applying two plausible definitions of acute respiratory distress syndrome onset time to severely injured trauma patients. A TRALI definition that standardizes acute respiratory distress syndrome onset time might improve reliability and align efforts to understand epidemiology, biology, and prevention.

Advanced Spectral Library (ASTRAL): Atomic Fluorescence in Cool, Evolved Stars

NASA Astrophysics Data System (ADS)

Carpenter, Ken G.; Nielsen, Krister E.; Kober, Gladys V.; Rau, Gioia

2018-01-01

The "Advanced Spectral Library (ASTRAL) Project: Cool Stars" (PI = T. Ayres) collected a definitive set of representative, high-resolution (R~46,000 in the FUV up to ~1700 Å, R~30,000 for 1700-2150 Å, and R~114,000 >2150 Å) and high signal/noise (S/N>100) UV spectra of eight F-M evolved cool stars. These extremely high-quality STIS UV echelle spectra are available from the HST archive and from the Univ. of Colorado (http://casa.colorado.edu/~ayres/ASTRAL/) and will enable investigations of a broad range of problems -- stellar, interstellar, and beyond -- for many years. In this paper, we extend our study of the very rich emission-line spectra of the four evolved K-M stars in the sample, Beta Gem (K0 IIIb), Gamma Dra (K5 III), Gamma Cru (M3.4 III), and Alpha Ori (M2 Iab), to study the atomic fluorescence processes operating in their outer atmospheres. We summarize the pumping transitions and fluorescent line products known on the basis of previous work (e.g. Carpenter 1988, etc.) and newly identified in our current, on-going analysis of these extraordinary ASTRAL STIS spectra.

The Evolution and Fossil History of Sensory Perception in Amniote Vertebrates

NASA Astrophysics Data System (ADS)

Müller, Johannes; Bickelmann, Constanze; Sobral, Gabriela

2018-05-01

Sensory perception is of crucial importance for animals to interact with their biotic and abiotic environment. In amniotes, the clade including modern mammals (Synapsida), modern reptiles (Reptilia), and their fossil relatives, the evolution of sensory perception took place in a stepwise manner after amniotes appeared in the Carboniferous. Fossil evidence suggests that Paleozoic taxa had only a limited amount of sensory capacities relative to later forms, with the majority of more sophisticated types of sensing evolving during the Triassic and Jurassic. Alongside the evolution of improved sensory capacities, various types of social communication evolved across different groups. At present there is no definitive evidence for a relationship between sensory evolution and species diversification. It cannot be excluded, however, that selection for improved sensing was partially triggered by biotic interactions, e.g., in the context of niche competition, whereas ecospace expansion, especially during the Mesozoic, might also have played an important role.

The evolving understanding of the construct of intellectual disability.

PubMed

Schalock, Robert L

2011-12-01

This article addresses two major areas concerned with the evolving understanding of the construct of intellectual disability. The first part of the article discusses current answers to five critical questions that have revolved around the general question, "What is Intellectual Disability?" These five are what to call the phenomenon, how to explain the phenomenon, how to define the phenomenon and determine who is a member of the class, how to classify persons so defined and identified, and how to establish public policy regarding such persons. The second part of the article discusses four critical issues that will impact both our future understanding of the construct and the approach taken to persons with intellectual disability. These four critical issues relate to the conceptualisation and measurement of intellectual functioning, the constitutive definition of intellectual disability, the alignment of clinical functions related to diagnosis, classification, and planning supports, and how the field resolves a number of emerging epistemological issues.

Space Station Mission Planning Study (MPS) development study. Volume 3: Software development plan

NASA Technical Reports Server (NTRS)

Klus, W. L.

1987-01-01

A software development plan is presented for the definition, design, and implementation of the Space Station (SS) Payload Mission Planning System (MPS). This plan is an evolving document and must be updated periodically as the SS design and operations concepts as well as the SS MPS concept evolve. The major segments of this plan are as follows: an overview of the SS MPS and a description of its required capabilities including the computer programs identified as configurable items with an explanation of the place and function of each within the system; an overview of the project plan and a detailed description of each development project activity breaking each into lower level tasks where applicable; identification of the resources required and recommendations for the manner in which they should be utilized including recommended schedules and estimated manpower requirements; and a description of the practices, standards, and techniques recommended for the SS MPS Software (SW) development.

The Potential Impact of Preventive HIV Vaccines in China: Results and Benefits of a Multi-Province Modeling Collaboration

PubMed Central

Harmon, Thomas; Guo, Wei; Stover, John; Wu, Zunyou; Kaufman, Joan; Schneider, Kammerle; Liu, Li; Feng, Liao; Schwartländer, Bernard

2015-01-01

China’s commitment to implementing established and emerging HIV/AIDS prevention and control strategies has led to substantial gains in terms of access to antiretroviral treatment and prevention services, but the evolving and multifaceted HIV/AIDS epidemic in China highlights the challenges of maintaining that response. This study presents modeling results exploring the potential impact of HIV vaccines in the Chinese context at varying efficacy and coverage rates, while further exploring the potential implications of vaccination programs aimed at reaching populations at highest risk of HIV infection. A preventive HIV vaccine would add a powerful tool to China’s response, even if not 100% efficacious or available to the full population. PMID:26344945

An evolution in interdisciplinary competencies to prevent and manage patient violence.

PubMed

Morton, Paula G

2002-01-01

Patient violence is a growing problem in healthcare institutions. Incidents of violence lead to injuries and increased operating costs. An innovative organizational approach to this problem is inclusion of interdisciplinary competency-based staff education and practice, as a key component of a comprehensive violence prevention program.Interdisciplinary competencies include a variety of behavioral responses, aimed at prevention, environmental, interpersonal, and physical interventions and postvention techniques for aggression and violence. Methods to maintain, monitor, document, and improve staff performance and skills are delineated. Organizational investment in such interdisciplinary competency-based education and practice evolves over time. Results include fewer incidents and injuries and enhanced interdisciplinary cooperation.

Violence: a glossary

PubMed Central

Rutherford, Alison; Zwi, Anthony B; Grove, Natalie J; Butchart, Alexander

2007-01-01

Violence has been explicitly identified as a significant public health problem. This glossary clarifies widely used definitions and concepts of violence within the public health field, building on those promoted through the 2002 World Report on Violence and Health. We provide definitions and concepts that can be usefully applied to identify points for public health intervention to prevent the social and health impacts of violence. PMID:17630364

Proposal for an Update of the Definition and Scope of Behavioral Medicine.

PubMed

Dekker, Joost; Stauder, Adrienne; Penedo, Frank J

2017-02-01

We aim to provide an update of the definition and scope of behavioral medicine in the Charter of ISBM, as the present version was developed more than 25 years ago. We identify issues which need clarification or updating. This leads us to propose an update of the definition and scope of behavioral medicine. Issues in need of clarification or updating include the scope of behavioral medicine (biobehavioral mechanisms, clinical diagnosis and intervention, and prevention and health promotion); research as an essential characteristic of all three areas of behavioral medicine; the application of behavioral medicine; the terminology of behavioral medicine as a multidisciplinary field; and the relationship and distinction between behavioral medicine, mental health, health psychology, and psychosomatic medicine. We propose the following updated definition and scope of behavioral medicine: "Behavioral medicine can be defined as the multidisciplinary field concerned with the development and integration of biomedical and behavioral knowledge relevant to health and disease, and the application of this knowledge to prevention, health promotion, diagnosis, treatment, rehabilitation, and care. The scope of behavioral medicine extends from biobehavioral mechanisms (i.e., the interaction of biomedical processes with psychological, social, societal, cultural, and environmental processes), to clinical diagnosis and intervention, and to public health."

Hypoglycaemia of the newborn: a review.

PubMed Central

Williams, A. F.

1997-01-01

It is almost a century since hypoglycaemia (a reduction in the glucose concentration of circulating blood) was first described in children, and over 50 years since the condition was first recognized in infants. Nevertheless, controversy still surrounds the definition, significance, and management of neonatal hypoglycaemia. Technological developments such as bedside glucose monitoring have, paradoxically, exacerbated rather than eased the situation. This article reviews the literature on hypoglycaemia of the newborn, and covers the following: historical aspects; glucose homeostasis and metabolic adaptation at birth; the effect of low blood glucose levels on the central nervous system; the definition of hypoglycaemia; screening; prevention; treatment; research needs; and concludes with recommendations for prevention and management. PMID:9277014

Organizing the HIV vaccine development effort.

PubMed

Voronin, Yegor; Snow, William

2013-09-01

To describe and compare the diverse organizational structures and funding mechanisms applied to advance HIV preventive vaccine research and development and to help explain and inform evolving infrastructures and collaborative funding models. On the basis of models that have been tried, improved or abandoned over three decades, the field seems to have settled into a relatively stable set of diverse initiatives, each with its own organizational signature. At the same time, this set of organizations is forging cross-organizational collaborations, which promise to acquire newly emergent beneficial properties. Strong motivation to expedite HIV vaccine R&D has driven a diversity of customized and inventive organizational approaches, largely government and foundation funded. Although no one approach has proven a panacea, the field has evolved into a constellation of often overlapping organizations that complement or reinforce one another. The Global HIV Vaccine Enterprise, a responsive, rapidly evolving loose infrastructure, is an innovative collaboration to catalyze that evolution.

Organizing the HIV Vaccine Development Effort

PubMed Central

Voronin, Yegor; Snow, William

2014-01-01

Purpose of Review Describe and compare the diverse organizational structures and funding mechanisms applied to advance HIV preventive vaccine research and development, to help explain and inform evolving infrastructures and collaborative funding models. Recent Findings Based on models that have been tried, improved or abandoned over three decades, the field seems to have settled into a relatively stable set of diverse initiatives, each with its own organizational signature. At the same time, this set of organizations is forging cross-organizational collaborations, which promise to acquire newly emergent beneficial properties. Summary Strong motivation to expedite HIV vaccine R&D has driven a diversity of customized and inventive organizational approaches, largely government and foundation funded. While no one approach has proven a panacea, the field has evolved into a constellation of often overlapping organizations that complement or reinforce one another. The Global HIV Vaccine Enterprise, a responsive, rapidly evolving loose infrastructure, is an innovative collaboration to catalyze that evolution. PMID:23924997

Tensions inherent in the evolving role of the infection preventionist.

PubMed

Conway, Laurie J; Raveis, Victoria H; Pogorzelska-Maziarz, Monika; Uchida, May; Stone, Patricia W; Larson, Elaine L

2013-11-01

The role of infection preventionists (IPs) is expanding in response to demands for quality and transparency in health care. Practice analyses and survey research have demonstrated that IPs spend a majority of their time on surveillance and are increasingly responsible for prevention activities and management; however, deeper qualitative aspects of the IP role have rarely been explored. We conducted a qualitative content analysis of in-depth interviews with 19 IPs at hospitals throughout the United States to describe the current IP role, specifically the ways that IPs effect improvements and the facilitators and barriers they face. The narratives document that the IP role is evolving in response to recent changes in the health care landscape and reveal that this progression is associated with friction and uncertainty. Tensions inherent in the evolving role of the IP emerged from the interviews as 4 broad themes: (1) expanding responsibilities outstrip resources, (2) shifting role boundaries create uncertainty, (3) evolving mechanisms of influence involve trade-offs, and (4) the stress of constant change is compounded by chronic recurring challenges. Advances in implementation science, data standardization, and training in leadership skills are needed to support IPs in their evolving role. Copyright © 2013 Association for Professionals in Infection Control and Epidemiology, Inc. Published by Mosby, Inc. All rights reserved.