Structural, Electronic and Elastic Properties of Heavy Fermion YbTM2 (TM= Ir and Pt) Laves Phase Compounds

NASA Astrophysics Data System (ADS)

Pawar, H.; Shugani, M.; Aynyas, M.; Sanyal, S. P.

2018-02-01

The structural, electronic and elastic properties of YbTM2 (TM = Ir and Pt) Laves phase intermetallic compounds which crystallize in cubic (MgCu2-type) structure, have been investigated using ab-initio full potential linearized augmented plane wave (FP-LAPW) method with LDA and LDA+U approximation. The calculated ground state properties such as lattice parameter (a0), bulk modulus (B) and its pressure derivative (B‧) are in good agreement with available experimental and theoretical data. The electronic properties are analyzed from band structures and density of states. Elastic constants are predicted first time for these compounds which obey the stability criteria for cubic system.

Thermal lensing and microchip laser performance of N g-cut Tm3+:KY(WO4)2 crystal

NASA Astrophysics Data System (ADS)

Gaponenko, M. S.; Loiko, P. A.; Gusakova, N. V.; Yumashev, K. V.; Kuleshov, N. V.; Pavlyuk, A. A.

2012-09-01

The thermal lensing effect was characterized in the diode-pumped monoclinic N g-cut Tm:KYW crystal under laser operation conditions at the wavelength of 1.94 μm. The thermal lens was found to be slightly astigmatic; its optical power D being positive for rays lying in all meridional planes. Thermal lens sensitivity factors M= dD/ dP abs equal 11.8 m-1/W and 8.8 m-1/W (with respect to the absorbed pump power P abs) for principal meridional planes containing N p and N m axes. Nearly athermal behavior of N g-cut crystal is associated with the mutual compensation of different impacts to the thermal lens optical power that arise from temperature dependence of the refractive index dn/ dT and anisotropic thermal expansion. It was utilized to produce passively cooled diode-pumped 0.65 W cw Tm:KYW microchip laser with slope efficiency of 44 % and low thermo-optic aberrations.

Systematics of electronic and magnetic properties in the transition metal doped Sb2Te3 quantum anomalous Hall platform

NASA Astrophysics Data System (ADS)

Islam, M. F.; Canali, C. M.; Pertsova, A.; Balatsky, A.; Mahatha, S. K.; Carbone, C.; Barla, A.; Kokh, K. A.; Tereshchenko, O. E.; Jiménez, E.; Brookes, N. B.; Gargiani, P.; Valvidares, M.; Schatz, S.; Peixoto, T. R. F.; Bentmann, H.; Reinert, F.; Jung, J.; Bathon, T.; Fauth, K.; Bode, M.; Sessi, P.

2018-04-01

The quantum anomalous Hall effect (QAHE) has recently been reported to emerge in magnetically doped topological insulators. Although its general phenomenology is well established, the microscopic origin is far from being properly understood and controlled. Here, we report on a detailed and systematic investigation of transition metal (TM) doped Sb2Te3 . By combining density functional theory calculations with complementary experimental techniques, i.e., scanning tunneling microscopy, resonant photoemission, and x-ray magnetic circular dichroism, we provide a complete spectroscopic characterization of both electronic and magnetic properties. Our results reveal that the TM dopants not only affect the magnetic state of the host material, but also significantly alter the electronic structure by generating impurity-derived energy bands. Our findings demonstrate the existence of a delicate interplay between electronic and magnetic properties in TM doped topological insulators. In particular, we find that the fate of the topological surface states critically depends on the specific character of the TM impurity: while V- and Fe-doped Sb2Te3 display resonant impurity states in the vicinity of the Dirac point, Cr and Mn impurities leave the energy gap unaffected. The single-ion magnetic anisotropy energy and easy axis, which control the magnetic gap opening and its stability, are also found to be strongly TM impurity dependent and can vary from in plane to out of plane depending on the impurity and its distance from the surface. Overall, our results provide general guidelines for the realization of a robust QAHE in TM doped Sb2Te3 in the ferromagnetic state.

Hydration behavior at the ice-binding surface of the Tenebrio molitor antifreeze protein.

PubMed

Midya, Uday Sankar; Bandyopadhyay, Sanjoy

2014-05-08

Molecular dynamics (MD) simulations have been carried out at two different temperatures (300 and 220 K) to study the conformational rigidity of the hyperactive Tenebrio molitor antifreeze protein (TmAFP) in aqueous medium and the structural arrangements of water molecules hydrating its surface. It is found that irrespective of the temperature the ice-binding surface (IBS) of the protein is relatively more rigid than its nonice-binding surface (NIBS). The presence of a set of regularly arranged internally bound water molecules is found to play an important role in maintaining the flat rigid nature of the IBS. Importantly, the calculations reveal that the strategically located hydroxyl oxygens of the threonine (Thr) residues in the IBS influence the arrangements of five sets of ordered waters around it on two parallel planes that closely resemble the basal plane of ice. As a result, these waters can register well with the ice basal plane, thereby allowing the IBS to preferentially bind at the ice interface and inhibit its growth. This provides a possible molecular reason behind the ice-binding activity of TmAFP at the basal plane of ice.

LANDSAT-4/5 image data quality analysis

NASA Technical Reports Server (NTRS)

Malaret, E.; Bartolucci, L. A.; Lozano, D. F.; Anuta, P. E.; Mcgillem, C. D.

1984-01-01

A LANDSAT Thematic Mapper (TM) quality evaluation study was conducted to identify geometric and radiometric sensor errors in the post-launch environment. The study began with the launch of LANDSAT-4. Several error conditions were found, including band-to-band misregistration and detector-to detector radiometric calibration errors. Similar analysis was made for the LANDSAT-5 Thematic Mapper and compared with results for LANDSAT-4. Remaining band-to-band misregistration was found to be within tolerances and detector-to-detector calibration errors were not severe. More coherent noise signals were observed in TM-5 than in TM-4, although the amplitude was generally less. The scan direction differences observed in TM-4 were still evident in TM-5. The largest effect was in Band 4 where nearly a one digital count difference was observed. Resolution estimation was carried out using roads in TM-5 for the primary focal plane bands rather than field edges as in TM-4. Estimates using roads gave better resolution. Thermal IR band calibration studies were conducted and new nonlinear calibration procedures were defined for TM-5. The overall conclusion is that there are no first order errors in TM-5 and any remaining problems are second or third order.

Chemical Microthruster Options

NASA Technical Reports Server (NTRS)

DeGroot, Wim; Oleson, Steve

1996-01-01

Chemical propulsion systems with potential application to microsatellites are classified by propellant phase, i.e. gas, liquid, or solid. Four promising concepts are selected based on performance, weight, size, cost, and reliability. The selected concepts, in varying stages of development, are advanced monopropellants, tridyne(TM), electrolysis, and solid gas generator propulsion. Tridyne(TM) and electrolysis propulsion are compared vs. existing cold gas and monopropellant systems for selected microsatellite missions. Electrolysis is shown to provide a significant weight advantage over monopropellant propulsion for an orbit transfer and plane change mission. Tridyne(TM) is shown to provide a significant advantage over cold gas thrusters for orbit trimming and spacecraft separation.

Twisted gravitational waves

NASA Astrophysics Data System (ADS)

Bini, Donato; Chicone, Carmen; Mashhoon, Bahram

2018-03-01

In general relativity (GR), linearized gravitational waves propagating in empty Minkowski spacetime along a fixed spatial direction have the property that the wave front is the Euclidean plane. Beyond the linear regime, exact plane waves in GR have been studied theoretically for a long time and many exact vacuum solutions of the gravitational field equations are known that represent plane gravitational waves. These have parallel rays and uniform wave fronts. It turns out, however, that GR also admits exact solutions representing gravitational waves propagating along a fixed direction that are nonplanar. The wave front is then nonuniform and the bundle of rays is twisted. We find a class of solutions representing nonplanar unidirectional gravitational waves and study some of the properties of these twisted waves.

MRI-guided tumor tracking in lung cancer radiotherapy

NASA Astrophysics Data System (ADS)

Cerviño, Laura I.; Du, Jiang; Jiang, Steve B.

2011-07-01

Precise tracking of lung tumor motion during treatment delivery still represents a challenge in radiation therapy. Prototypes of MRI-linac hybrid systems are being created which have the potential of ionization-free real-time imaging of the tumor. This study evaluates the performance of lung tumor tracking algorithms in cine-MRI sagittal images from five healthy volunteers. Visible vascular structures were used as targets. Volunteers performed several series of regular and irregular breathing. Two tracking algorithms were implemented and evaluated: a template matching (TM) algorithm in combination with surrogate tracking using the diaphragm (surrogate was used when the maximum correlation between the template and the image in the search window was less than specified), and an artificial neural network (ANN) model based on the principal components of a region of interest that encompasses the target motion. The mean tracking error ē and the error at 95% confidence level e95 were evaluated for each model. The ANN model led to ē = 1.5 mm and e95 = 4.2 mm, while TM led to ē = 0.6 mm and e95 = 1.0 mm. An extra series was considered separately to evaluate the benefit of using surrogate tracking in combination with TM when target out-of-plane motion occurs. For this series, the mean error was 7.2 mm using only TM and 1.7 mm when the surrogate was used in combination with TM. Results show that, as opposed to tracking with other imaging modalities, ANN does not perform well in MR-guided tracking. TM, however, leads to highly accurate tracking. Out-of-plane motion could be addressed by surrogate tracking using the diaphragm, which can be easily identified in the images.

Differential Diagnosis in Idiopathic Granulomatous Mastitis and Tuberculous Mastitis

PubMed Central

Seo, Hee Ri Na; Na, Kuk Young; Yim, Hyun Ee; Kim, Tae Hee; Kang, Doo Kyoung; Oh, Ki Keun; Kang, Seok Yun; An, Young-Sil; Chun, Mison; Kim, Woojae; Park, Rae Woong; Jung, Yong Sik

2012-01-01

Purpose Idiopathic granulomatous mastitis (IGM) is a rare chronic inflammatory disease of unknown etiology. The diagnosis of IGM requires that other granulomatous lesions in the breast be excluded. Tuberculous mastitis (TM) is also an uncommon disease that is often difficult to differentiate from IGM. The purpose of this study is to develop a new algorithm for the differential diagnosis and treatment of IGM and TM. Methods Medical records of 68 patients (58 with IGM and 10 with TM) between July 1999 and February 2009 were retrospectively reviewed. Results The mean age of the patients was 33.5 (IGM) and 40 (TM) years (p=0.018). The median follow-up was 84 months. Of the total 10 patients with TM, 5 patients had a history of pulmonary tuberculosis. The most common symptoms of the diseases were breast lump and pain. However, axillary lymphadenopathy was more seen in TM (50%) compared to IGM (20.6%) (p=0.048). TM showed more cancer-mimicking findings on radiologic study (p=0.028). In IGM, 48 patients (82.7%) underwent surgical wide excision and 21 patients (36.2%) were managed with corticosteroid therapy and antibiotics. All of the TM patients received anti-tuberculosis medications and 9 patients (90%) underwent wide excision. The mean treatment duration was 2.8 months in IGM and 8.4 months in TM. Recurrence developed in 5 patients (8.6%) in IGM and 1 patient (10%) in TM. Conclusion This study shows different characteristics between IGM and TM. The IGM patients were younger and had more mastalgia symptoms than the TM patients. Axillary lymphadenopathy was seen more often in TM patients. Half of the TM patients had pulmonary tuberculosis or tuberculosis lymphadenitis. Surgical wide excision might be both therapeutic and useful for providing an exact diagnosis. PMID:22493637

Eshelby problem of polygonal inclusions in anisotropic piezoelectric full- and half-planes

NASA Astrophysics Data System (ADS)

Pan, E.

2004-03-01

This paper presents an exact closed-form solution for the Eshelby problem of polygonal inclusion in anisotropic piezoelectric full- and half-planes. Based on the equivalent body-force concept of eigenstrain, the induced elastic and piezoelectric fields are first expressed in terms of line integral on the boundary of the inclusion with the integrand being the Green's function. Using the recently derived exact closed-form line-source Green's function, the line integral is then carried out analytically, with the final expression involving only elementary functions. The exact closed-form solution is applied to a square-shaped quantum wire within semiconductor GaAs full- and half-planes, with results clearly showing the importance of material orientation and piezoelectric coupling. While the elastic and piezoelectric fields within the square-shaped quantum wire could serve as benchmarks to other numerical methods, the exact closed-form solution should be useful to the analysis of nanoscale quantum-wire structures where large strain and electric fields could be induced by the misfit strain.

A numerical comparison with an exact solution for the transient response of a cylinder immersed in a fluid. [computer simulated underwater tests to determine transient response of a submerged cylindrical shell

NASA Technical Reports Server (NTRS)

Giltrud, M. E.; Lucas, D. S.

1979-01-01

The transient response of an elastic cylindrical shell immersed in an acoustic media that is engulfed by a plane wave is determined numerically. The method applies to the USA-STAGS code which utilizes the finite element method for the structural analysis and the doubly asymptotic approximation for the fluid-structure interaction. The calculations are compared to an exact analysis for two separate loading cases: a plane step wave and an exponentially decaying plane wave.

An analysis of Landsat Thematic Mapper P-Product internal geometry and conformity to earth surface geometry

NASA Technical Reports Server (NTRS)

Bryant, N. A.; Zobrist, A. L.; Walker, R. E.; Gokhman, B.

1985-01-01

Performance requirements regarding geometric accuracy have been defined in terms of end product goals, but until recently no precise details have been given concerning the conditions under which that accuracy is to be achieved. In order to achieve higher spatial and spectral resolutions, the Thematic Mapper (TM) sensor was designed to image in both forward and reverse mirror sweeps in two separate focal planes. Both hardware and software have been augmented and changed during the course of the Landsat TM developments to achieve improved geometric accuracy. An investigation has been conducted to determine if the TM meets the National Map Accuracy Standards for geometric accuracy at larger scales. It was found that TM imagery, in terms of geometry, has come close to, and in some cases exceeded, its stringent specifications.

Third Chromosome Balancer Inversions Disrupt Protein-Coding Genes and Influence Distal Recombination Events in Drosophila melanogaster

PubMed Central

Miller, Danny E.; Cook, Kevin R.; Arvanitakis, Alexandra V.; Hawley, R. Scott

2016-01-01

Balancer chromosomes are multiply inverted chromosomes that suppress meiotic crossing over and prevent the recovery of crossover products. Balancers are commonly used in Drosophila melanogaster to maintain deleterious alleles and in stock construction. They exist for all three major chromosomes, yet the molecular location of the breakpoints and the exact nature of many of the mutations carried by the second and third chromosome balancers has not been available. Here, we precisely locate eight of 10 of the breakpoints on the third chromosome balancer TM3, six of eight on TM6, and nine of 11 breakpoints on TM6B. We find that one of the inversion breakpoints on TM3 bisects the highly conserved tumor suppressor gene p53—a finding that may have important consequences for a wide range of studies in Drosophila. We also identify evidence of single and double crossovers between several TM3 and TM6B balancers and their normal-sequence homologs that have created genetic diversity among these chromosomes. Overall, this work demonstrates the practical importance of precisely identifying the position of inversion breakpoints of balancer chromosomes and characterizing the mutant alleles carried by them. PMID:27172211

Assessment of Thematic Mapper band-to-band registration by the block correlation method

NASA Technical Reports Server (NTRS)

Card, D. H.; Wrigley, R. C.; Mertz, F. C.; Hall, J. R.

1983-01-01

Rectangular blocks of pixels from one band image were statistically correlated against blocks centered on identical pixels from a second band image. The block pairs were shifted in pixel increments both vertically and horizontally with respect to each other and the correlation coefficient to the maximum correlation was taken as the best estimate of registration error for each block pair. For the band combinations of the Arkansas scene studied, the misregistration of TM spectral bands within the noncooled focal plane lie well within the 0.2 pixel target specification. Misregistration between the middle IR bands is well within this specification also. The thermal IR band has an apparent misregistration with TM band 7 of approximately 3 pixels in each direction. The TM band 3 has a misregistration of approximately 0.2 pixel in the across-scan direction and 0.5 pixel in the along-scan direction, with both TM bands 5 and 7.

Assessment of Thematic Mapper Band-to-band Registration by the Block Correlation Method

NASA Technical Reports Server (NTRS)

Card, D. H.; Wrigley, R. C.; Mertz, F. C.; Hall, J. R.

1985-01-01

Rectangular blocks of pixels from one band image were statistically correlated against blocks centered on identical pixels from a second band image. The block pairs were shifted in pixel increments both vertically and horizontally with respect to each other and the correlation coefficient to the maximum correlation was taken as the best estimate of registration error for each block pair. For the band combinations of the Arkansas scene studied, the misregistration of TM spectral bands within the noncooled focal plane lie well within the 0.2 pixel target specification. Misregistration between the middle IR bands is well within this specification also. The thermal IR band has an apparent misregistration with TM band 7 of approximately 3 pixels in each direction. The TM band 3 has a misregistration of approximately 0.2 pixel in the across-scan direction and 0.5 pixel in the along-scan direction, with both TM bands 5 and 7.

An exact plane-stress solution for a class of problems in orthotropic elasticity

NASA Technical Reports Server (NTRS)

Erb, D. A.; Cooper, P. A.; Weisshaar, T. A.

1982-01-01

An exact solution for the stress field within a rectangular slab of orthotropic material is found using a two dimensional Fourier series formulation. The material is required to be in plane stress, with general stress boundary conditions, and the principle axes of the material must be parallel to the sides of the rectangle. Two load cases similar to those encountered in materials testing are investigated using the solution. The solution method has potential uses in stress analysis of composite structures.

Strong magnetic coupling in the hexagonal R5Pb3 compounds (R=Gd-Tm)

NASA Astrophysics Data System (ADS)

Marcinkova, Andrea; de la Cruz, Clarina; Yip, Joshua; Zhao, Liang L.; Wang, Jiakui K.; Svanidze, E.; Morosan, E.

2015-06-01

We have synthesized the R5Pb3 (R=Gd-Tm) compounds in polycrystalline form and performed neutron scattering and magnetization measurements. For all R5Pb3 reported here the Weiss temperatures θW are several times smaller than the ordering temperatures TORD, while the latter are remarkably high (TORD up to 275 K for R=Gd) compared to other known R-M binaries (M=Si, Ge, Sn and Sb). The magnetic order changes from ferromagnetic (FM) in R=Gd, Tb to antiferromagnetic (AFM) in R=Dy-Tm. Below TORD, the magnetization measurements together with neutron powder diffraction show complex magnetic behaviors and reveal the existence of up to three additional phase transitions, believed to be a result of large anisotropic exchange and/or crystal electric field effects, induced high anisotropy. The R5Pb3 magnetic unit cells for R=Tb-Tm can be described with incommensurate magnetic wave vectors with spin modulation either along the c axis in R=Tb, Er and Tm, or within the ab plane in R=Dy and Ho.

Investigation of angular dependence on photonic bandgap for 1-D photonic crystal

NASA Astrophysics Data System (ADS)

Nigam, Anjali; Suthar, B.; Bhargava, A.; Vijay, Y. K.

2018-05-01

In the present communication, we study the one-dimensional photonic crystal structure. The photonic band structure has been obtained using Plane Wave Expansion Method (PWEM). The studied has been extended to investigate the angular dependence on photonic bandgap for 1-D photonic crystal. The photonic bandgap is same both for TE and TM mode for normal incidence, while both mode move separate with an incidence angle. The photonic bandgap is almost unaffected with angle for TE mode while the bandgap decreases with an incidence angle for TM mode.

TM9/Phg1 and SadA proteins control surface expression and stability of SibA adhesion molecules in Dictyostelium.

PubMed

Froquet, Romain; le Coadic, Marion; Perrin, Jackie; Cherix, Nathalie; Cornillon, Sophie; Cosson, Pierre

2012-02-01

TM9 proteins form a family of conserved proteins with nine transmembrane domains essential for cellular adhesion in many biological systems, but their exact role in this process remains unknown. In this study, we found that genetic inactivation of the TM9 protein Phg1A dramatically decreases the surface levels of the SibA adhesion molecule in Dictyostelium amoebae. This is due to a decrease in sibA mRNA levels, in SibA protein stability, and in SibA targeting to the cell surface. A similar phenotype was observed in cells devoid of SadA, a protein that does not belong to the TM9 family but also exhibits nine transmembrane domains and is essential for cellular adhesion. A contact site A (csA)-SibA chimeric protein comprising only the transmembrane and cytosolic domains of SibA and the extracellular domain of the Dictyostelium surface protein csA also showed reduced stability and relocalization to endocytic compartments in phg1A knockout cells. These results indicate that TM9 proteins participate in cell adhesion by controlling the levels of adhesion proteins present at the cell surface.

RT DDA: A hybrid method for predicting the scattering properties by densely packed media

NASA Astrophysics Data System (ADS)

Ramezan Pour, B.; Mackowski, D.

2017-12-01

The most accurate approaches to predicting the scattering properties of particulate media are based on exact solutions of the Maxwell's equations (MEs), such as the T-matrix and discrete dipole methods. Applying these techniques for optically thick targets is challenging problem due to the large-scale computations and are usually substituted by phenomenological radiative transfer (RT) methods. On the other hand, the RT technique is of questionable validity in media with large particle packing densities. In recent works, we used numerically exact ME solvers to examine the effects of particle concentration on the polarized reflection properties of plane parallel random media. The simulations were performed for plane parallel layers of wavelength-sized spherical particles, and results were compared with RT predictions. We have shown that RTE results monotonically converge to the exact solution as the particle volume fraction becomes smaller and one can observe a nearly perfect fit for packing densities of 2%-5%. This study describes the hybrid technique composed of exact and numerical scalar RT methods. The exact methodology in this work is the plane parallel discrete dipole approximation whereas the numerical method is based on the adding and doubling method. This approach not only decreases the computational time owing to the RT method but also includes the interference and multiple scattering effects, so it may be applicable to large particle density conditions.

Robust Multigrid Smoothers for Three Dimensional Elliptic Equations with Strong Anisotropies

NASA Technical Reports Server (NTRS)

Llorente, Ignacio M.; Melson, N. Duane

1998-01-01

We discuss the behavior of several plane relaxation methods as multigrid smoothers for the solution of a discrete anisotropic elliptic model problem on cell-centered grids. The methods compared are plane Jacobi with damping, plane Jacobi with partial damping, plane Gauss-Seidel, plane zebra Gauss-Seidel, and line Gauss-Seidel. Based on numerical experiments and local mode analysis, we compare the smoothing factor of the different methods in the presence of strong anisotropies. A four-color Gauss-Seidel method is found to have the best numerical and architectural properties of the methods considered in the present work. Although alternating direction plane relaxation schemes are simpler and more robust than other approaches, they are not currently used in industrial and production codes because they require the solution of a two-dimensional problem for each plane in each direction. We verify the theoretical predictions of Thole and Trottenberg that an exact solution of each plane is not necessary and that a single two-dimensional multigrid cycle gives the same result as an exact solution, in much less execution time. Parallelization of the two-dimensional multigrid cycles, the kernel of the three-dimensional implicit solver, is also discussed. Alternating-plane smoothers are found to be highly efficient multigrid smoothers for anisotropic elliptic problems.

Structural properties of lanthanide and actinide compounds within the plane wave pseudopotential approach

PubMed

Pickard; Winkler; Chen; Payne; Lee; Lin; White; Milman; Vanderbilt

2000-12-11

We show that plane wave ultrasoft pseudopotential methods readily extend to the calculation of the structural properties of lanthanide and actinide containing compounds. This is demonstrated through a series of calculations performed on UO, UO2, UO3, U3O8, UC2, alpha-CeC2, CeB6, CeSe, CeO2, NdB6, TmOI, LaBi, LaTiO3, YbO, and elemental Lu.

Nonexistence of exact solutions agreeing with the Gaussian beam on the beam axis or in the focal plane

NASA Astrophysics Data System (ADS)

Lekner, John; Andrejic, Petar

2018-01-01

Solutions of the Helmholtz equation which describe electromagnetic beams (and also acoustic or particle beams) are discussed. We show that an exact solution which reproduces the Gaussian beam waveform on the beam axis does not exist. This is surprising, since the Gaussian beam is a solution of the paraxial equation, and thus supposedly accurate on and near the beam axis. Likewise, a solution of the Helmholtz equation which exactly reproduces the Gaussian beam in the focal plane does not exist. We show that the last statement also holds for Bessel-Gauss beams. However, solutions of the Helmholtz equation (one of which is discussed in detail) can approximate the Gaussian waveform within the central focal region.

Technical note: patient-specific quality assurance methods for TomoDirect(TM) whole breast treatment delivery.

PubMed

Catuzzo, P; Zenone, F; Aimonetto, S; Peruzzo, A; Casanova Borca, V; Pasquino, M; Franco, P; La Porta, M R; Ricardi, U; Tofani, S

2012-07-01

To investigate the feasibility of implementing a novel approach for patient-specific QA of TomoDirect(TM) whole breast treatment. The most currently used TomoTherapy DQA method, consisting in the verification of the 2D dose distribution in a coronal or sagittal plane of the Cheese Phantom by means of gafchromic films, was compared with an alternative approach based on the use of two commercially available diode arrays, MapCHECK2(TM) and ArcCHECK(TM). The TomoDirect(TM) plans of twenty patients with a primary unilateral breast cancer were applied to a CT scan of the Cheese Phantom and a MVCT dataset of the diode arrays. Then measurements of 2D dose distribution were performed and compared with the calculated ones using the gamma analysis method with different sets of DTA and DD criteria (3%-3 mm, 3%-2 mm). The sensitivity of the diode arrays to detect delivery and setup errors was also investigated. The measured dose distributions showed excellent agreement with the TPS calculations for each detector, with averaged fractions of passed Γ values greater than 95%. The percentage of points satisfying the constraint Γ < 1 was significantly higher for MapCHECK2(TM) than for ArcCHECK(TM) and gafchromic films using both the 3%-3 mm and 3%-2 mm gamma criteria. Both the diode arrays show a good sensitivity to delivery and setup errors using a 3%-2 mm gamma criteria. MapCHECK2™ and ArcCHECK(TM) may fulfill the demands of an adequate system for TomoDirect(TM) patient-specific QA.

Comparison of telemedicine with in-person care for follow-up after elective neurosurgery: results of a cost-effectiveness analysis of 1200 patients using patient-perceived utility scores.

PubMed

Thakar, Sumit; Rajagopal, Niranjana; Mani, Subramaniyan; Shyam, Maya; Aryan, Saritha; Rao, Arun S; Srinivasa, Rakshith; Mohan, Dilip; Hegde, Alangar S

2018-05-01

OBJECTIVE The utility of telemedicine (TM) in neurosurgery is underexplored, with most of the studies relating to teletrauma or telestroke programs. In this study, the authors evaluate the cost-effectiveness of TM consultations for follow-up care of a large population of patients who underwent neurosurgical procedures. METHODS A decision-analytical model was used to assess the cost-effectiveness of TM for elective post-neurosurgical care patients from a predominantly nonurban cohort in West Bengal, India. The model compared TM care via a nodal center in West Bengal to routine, in-person, per-episode care at the provider site in Bangalore, India. Cost and effectiveness data relating to 1200 patients were collected for a 52-month period. The effectiveness of TM care was calculated using efficiency in terms of the percentage of successful TM consultations, as well as patient-perceived utility values for overall experience of the type of health care access that they received. Incremental cost-effectiveness ratio (ICER) analysis was done using the 4-quadrant charting of the cost-effectiveness plane. One-way sensitivity and tornado analyses were performed to identify thresholds where the care strategy would change. RESULTS The overall utility for the 3 TM scenarios was found to be higher (89%) than for the utility of routine care (80%). TM was found to be more cost-effective (Indian rupee [INR] 2630 per patient) compared to routine care (INR 6848 per patient). The TM strategy "dominates" that of routine care by being more effective and less expensive (ICER value of -39,400 INR/unit of effectiveness). Sensitivity analysis revealed that cost-effectiveness of TM was most sensitive to changes in the number of TM patients, utility and success rate of TM, and travel distance to the TM center. CONCLUSIONS TM care dominates the in-person care strategy by providing more effective and less expensive follow-up care for a remote post-neurosurgical care population in India. In the authors' setting, this benefit of TM is sustainable even if half the TM consultations turn out to be unsuccessful. The viability of TM as a cost-effective care protocol is attributed to a combination of factors, like an adequate patient volume utilizing TM, patient utility, success rate of TM, and the patient travel distance.

Transition metal decorated graphene-like zinc oxide monolayer: A first-principles investigation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lei, Jie; School of Science, Qilu University of Technology, Jinan, Shandong 250353; Xu, Ming-Chun

Transition metal (TM) atoms have been extensively employed to decorate the two-dimensional materials, endowing them with promising physical properties. Here, we have studied the adsorption of TM atoms (V, Cr, Mn, Fe, and Co) on graphene-like zinc oxide monolayer (g-ZnO) and the substitution of Zn by TM using first-principles calculations to search for the most likely configurations when TM atoms are deposited on g-ZnO. We found that when a V atom is initially placed on the top of Zn atom, V will squeeze out Zn from the two-dimensional plane then substitute it, which is a no barrier substitution process. Formore » heavier elements (Cr to Co), although the substitution configurations are more stable than the adsorption ones, there is an energy barrier for the adsorption-substitution transition with the height of tens to hundreds meV. Therefore, Cr to Co prefers to be adsorbed on the hollow site or the top of oxygen, which is further verified by the molecular dynamics simulations. The decoration of TM is revealed to be a promising approach in terms of tuning the work function of g-ZnO in a large energy range.« less

Transition metal decorated graphene-like zinc oxide monolayer: A first-principles investigation

NASA Astrophysics Data System (ADS)

Lei, Jie; Xu, Ming-Chun; Hu, Shu-Jun

2015-09-01

Transition metal (TM) atoms have been extensively employed to decorate the two-dimensional materials, endowing them with promising physical properties. Here, we have studied the adsorption of TM atoms (V, Cr, Mn, Fe, and Co) on graphene-like zinc oxide monolayer (g-ZnO) and the substitution of Zn by TM using first-principles calculations to search for the most likely configurations when TM atoms are deposited on g-ZnO. We found that when a V atom is initially placed on the top of Zn atom, V will squeeze out Zn from the two-dimensional plane then substitute it, which is a no barrier substitution process. For heavier elements (Cr to Co), although the substitution configurations are more stable than the adsorption ones, there is an energy barrier for the adsorption-substitution transition with the height of tens to hundreds meV. Therefore, Cr to Co prefers to be adsorbed on the hollow site or the top of oxygen, which is further verified by the molecular dynamics simulations. The decoration of TM is revealed to be a promising approach in terms of tuning the work function of g-ZnO in a large energy range.

Efficient Calculation of Exact Exchange Within the Quantum Espresso Software Package

NASA Astrophysics Data System (ADS)

Barnes, Taylor; Kurth, Thorsten; Carrier, Pierre; Wichmann, Nathan; Prendergast, David; Kent, Paul; Deslippe, Jack

Accurate simulation of condensed matter at the nanoscale requires careful treatment of the exchange interaction between electrons. In the context of plane-wave DFT, these interactions are typically represented through the use of approximate functionals. Greater accuracy can often be obtained through the use of functionals that incorporate some fraction of exact exchange; however, evaluation of the exact exchange potential is often prohibitively expensive. We present an improved algorithm for the parallel computation of exact exchange in Quantum Espresso, an open-source software package for plane-wave DFT simulation. Through the use of aggressive load balancing and on-the-fly transformation of internal data structures, our code exhibits speedups of approximately an order of magnitude for practical calculations. Additional optimizations are presented targeting the many-core Intel Xeon-Phi ``Knights Landing'' architecture, which largely powers NERSC's new Cori system. We demonstrate the successful application of the code to difficult problems, including simulation of water at a platinum interface and computation of the X-ray absorption spectra of transition metal oxides.

Optical Anisotropy and Waveguiding in Thin Films of a Conjugated Polymer Which Exhibits Stimulated Emission.

NASA Astrophysics Data System (ADS)

Miller, E. Kirk; McGehee, Michael; Diaz-Garcia, Maria; Srikant, V.; Heeger, Alan J.

1998-03-01

We report variable angle spectroscopic ellipsometry (VASE) measurements on thin films of poly(2-butyl-5(2-ethyl-hexyl)-1,4- phenylenevinylene) (BuEH-PPV) in the spectral region below the electronic absorption edge. We find that the films are best described as uniaxially anisotropic, with the optical axis perpendicular to the plane of the film, consistent with the notion that the polymer chains lie preferentially in the plane of the film. Due to the anisotropic distribution of chromophores, the in-plane index of refraction is found to be significantly higher and more dispersive than the out-of- plane index, implying a higher effective index for transverse-electric (TE) waveguide modes than for the corresponding transverse- magnetic (TM) modes. The implications of these data for amplified spontaneous emission (ASE) experiments and in-plane laser structures are discussed.

Exact solutions for coupled Einstein, Dirac, Maxwell, and zero-mass scalar fields

DOE Office of Scientific and Technical Information (OSTI.GOV)

Patra, A.C.; Ray, D.

1987-12-01

Coupled equations for Einstein, Maxwell, Dirac, and zero-mass scalar fields studied by Krori, Bhattacharya, and Nandi are integrated for plane-symmetric time-independent case. It is shown that solutions do not exist for the plane-symmetric time-dependent case.

POLYSITE - An interactive package for the selection and refinement of Landsat image training sites

NASA Technical Reports Server (NTRS)

Mack, Marilyn J. P.

1986-01-01

A versatile multifunction package, POLYSITE, developed for Goddard's Land Analysis System, is described which simplifies the process of interactively selecting and correcting the sites used to study Landsat TM and MSS images. Image switching between the zoomed and nonzoomed image, color and shape cursor change and location display, and bit plane erase or color change, are global functions which are active at all times. Local functions possibly include manipulation of intensive study areas, new site definition, mensuration, and new image copying. The program is illustrated with the example of a full TM maser scene of metropolitan Washington, DC.

Exact image theory for the problem of dielectric/magnetic slab

NASA Technical Reports Server (NTRS)

Lindell, I. V.

1987-01-01

Exact image method, recently introduced for the exact solution of electromagnetic field problems involving homogeneous half spaces and microstrip-like geometries, is developed for the problem of homogeneous slab of dielectric and/or magnetic material in free space. Expressions for image sources, creating the exact reflected and transmitted fields, are given and their numerical evaluation is demonstrated. Nonradiating modes, guided by the slab and responsible for the loss of convergence of the image functions, are considered and extracted. The theory allows, for example, an analysis of finite ground planes in microstrip antenna structures.

The memory effect for plane gravitational waves

NASA Astrophysics Data System (ADS)

Zhang, P.-M.; Duval, C.; Gibbons, G. W.; Horvathy, P. A.

2017-09-01

We give an account of the gravitational memory effect in the presence of the exact plane wave solution of Einstein's vacuum equations. This allows an elementary but exact description of the soft gravitons and how their presence may be detected by observing the motion of freely falling particles. The theorem of Bondi and Pirani on caustics (for which we present a new proof) implies that the asymptotic relative velocity is constant but not zero, in contradiction with the permanent displacement claimed by Zel'dovich and Polnarev. A non-vanishing asymptotic relative velocity might be used to detect gravitational waves through the "velocity memory effect", considered by Braginsky, Thorne, Grishchuk, and Polnarev.

Interference effects in phased beam tracing using exact half-space solutions.

PubMed

Boucher, Matthew A; Pluymers, Bert; Desmet, Wim

2016-12-01

Geometrical acoustics provides a correct solution to the wave equation for rectangular rooms with rigid boundaries and is an accurate approximation at high frequencies with nearly hard walls. When interference effects are important, phased geometrical acoustics is employed in order to account for phase shifts due to propagation and reflection. Error increases, however, with more absorption, complex impedance values, grazing incidence, smaller volumes and lower frequencies. Replacing the plane wave reflection coefficient with a spherical one reduces the error but results in slower convergence. Frequency-dependent stopping criteria are then applied to avoid calculating higher order reflections for frequencies that have already converged. Exact half-space solutions are used to derive two additional spherical wave reflection coefficients: (i) the Sommerfeld integral, consisting of a plane wave decomposition of a point source and (ii) a line of image sources located at complex coordinates. Phased beam tracing using exact half-space solutions agrees well with the finite element method for rectangular rooms with absorbing boundaries, at low frequencies and for rooms with different aspect ratios. Results are accurate even for long source-to-receiver distances. Finally, the crossover frequency between the plane and spherical wave reflection coefficients is discussed.

Comparison of outgassing models for the landsat thematic mapper sensors

USGS Publications Warehouse

Micijevic, E.; Chander, G.

2007-01-01

The Thematic Mapper (TM) is a multi-spectral electro-optical sensor featured onboard both the Landsat 4 (L4) and Landsat 5 (L5) satellites. TM sensors have seven spectral bands with center wavelengths of approximately 0.49, 0.56, 0.66, 0.83, 1.65, 11.5 and 2.21 ??m, respectively. The visible near-infrared (VNIR) bands are located on the primary focal plane (PFP), and two short-wave infrared (SWIR) bands and the thermal infrared (TIR) band are located on the cold focal plane (CFP). The CFP bands are maintained at cryogenic temperatures of about 91 K, to reduce thermal noise effects. Due to the cold temperature, an ice film accumulates on the CFP dewar window, which introduces oscillations in SWIR and an exponential decay in TIR band responses. This process is usually monitored and characterized by the detector responses to the internal calibrator (IC) lamps and the blackbody. The ice contamination on the dewar window is an effect of the sensor outgassing in a vacuum of the space environment. Outgassing models have been developed, which are based on the thin-film optical interference phenomenon. They provide the coefficients for correction for outgassing effects for the entire mission's lifetime. While the L4 TM ceased imaging in August 1993, the L5 TM continues to operate even after more than 23 years in orbit. The process of outgassing in L5 TM is still occurring, though at a much lower rate than during early years of mission. Although the L4 and L5 TM sensors are essentially identical, they exhibit slightly different responses to the outgassing effects. The work presented in the paper summarizes the results of modeling outgassing effects in each of the sensors and provides a detailed analysis of differences among the estimated modeling parameters. For both sensors, water ice was confirmed as a reasonable candidate for contaminant material, the contaminant growth rate was found to be gradually decreasing with the time since launch, and the indications exist that some film may remain after the CFP warm-up procedures, which are periodically initiated to remove accumulated contamination. The observed difference between the models could be contributed to differences in the operational history for the sensors, the content and amount of contaminant impurities, the sensor spectral filter responses, and the internal calibrator systems.

Forces. Physical Science in Action[TM]. Schlessinger Science Library. [Videotape].

ERIC Educational Resources Information Center

2000

Forces are all around. Without them, there would be no movement. In fact, Sir Isaac Newton theorized that a force called inertia actually works to keep things exactly as they are at any given moment! Students will learn about Newton's laws and about how forces affect many aspects of life. With clear demonstrations and a unique hands-on activity,…

TM surface wave diffraction by a truncated dielectric slab recessed in a perfectly conducting surface. [considering flush mounted space shuttle antenna

NASA Technical Reports Server (NTRS)

Pathak, P. H.; Kouyoumjian, R. G.

1974-01-01

The diffraction of a TM sub o surface wave by a terminated dielectric slab which is flush mounted in a perfectly conducting surface is studied. The incident surface wave gives rise to waves reflected and diffracted by the termination; these reflected and diffracted fields may be expressed in terms of the geometrical theory of diffraction by introducing surface wave reflection and diffraction coefficients which are associated with the termination. In this investigation, the surface wave reflection and diffraction coefficients have been deduced from a formally exact solution to this canonical problem. The solution is obtained by a combination of the generalized scattering matrix technique and function theoretic methods.

Self-collimating photonic crystal polarization beam splitter.

PubMed

Zabelin, V; Dunbar, L A; Le Thomas, N; Houdré, R; Kotlyar, M V; O'Faolain, L; Krauss, T F

2007-03-01

We present theoretical and experimental results of a polarization splitter device that consists of a photonic crystal (PhC) slab, which exhibits a large reflection coefficient for TE and a high transmission coefficient for TM polarization. The slab is embedded in a PhC tile operating in the self-collimation mode. Embedding the polarization-discriminating slab in a PhC with identical lattice symmetry suppresses the in-plane diffraction losses at the PhC-non-PhC interface. The optimization of the PhC-non-PhC interface is thereby decoupled from the optimization of the polarizing function. Transmissions as high as 35% for TM- and 30% for TE-polarized light are reported.

Harbingers and latecomers - the order of appearance of exact coherent structures in plane Poiseuille flow

NASA Astrophysics Data System (ADS)

Zammert, Stefan; Eckhardt, Bruno

2017-02-01

The transition to turbulence in plane Poiseuille flow (PPF) is connected with the presence of exact coherent structures. We here discuss a variety of different structures that are relevant for the transition, compare the critical Reynolds numbers and optimal wavelengths for their appearance, and explore the differences between flows operating at constant mass flux or at constant pressure drop. The Reynolds numbers quoted here are based on the mean flow velocity and refer to constant mass flux. Reynolds numbers based on constant pressure drop are always higher. The Tollmien-Schlichting (TS) waves bifurcate subcritically from the laminar profile at Re = 5772 at wavelength 6.16 and reach down to Re = 2610 at a different optimal wave length of 4.65. Their streamwise localised counter part bifurcates at the even lower value Re = 2334. Three-dimensional exact solutions appear at much lower Reynolds numbers. We describe one exact solutions that has a critical Reynolds number of 316. Streamwise localised versions of this state require higher Reynolds numbers, with the lowest bifurcation occurring near Re = 1018. The analysis shows that the various branches of TS-waves cannot be connected with transition observed near Re ≈ 1000 and that the exact coherent structures related to downstream vortices come in at lower Reynolds numbers and prepare for the transition.

Evidence of in-plane ferromagnetic order probed by planar Hall effect in the geometry-confined ruthenate S r4R u3O10

NASA Astrophysics Data System (ADS)

Liu, Yan; Yang, Jiyong; Wang, Weike; Du, Haifeng; Ning, Wei; Ling, Langsheng; Tong, Wei; Qu, Zhe; Cao, Gang; Zhang, Yuheng; Tian, Mingliang

2017-04-01

The magnetic structure in the strongly correlated ruthenate S r4R u3O10 has been debated for a long time and still remains elusive. Here, we perform a systematically planar Hall effect study on a single-crystalline S r4R u3O10 nanostripe with a thickness of less than 100 nm. Large sharp switching behavior is observed in the planar Hall resistance, unambiguously indicating a strong anisotropic in-plane ferromagnetic order in the nanostripe, which is in contrast to the bulk system. Temperature-dependent evolution of the in-plane magnetism reveals that the in-plane spin order transforms from a single-domain state below a Curie temperature TC into a multidomain state below a critical temperature TM, probably due to the inherent strong spin-orbit coupling driven reconfiguration of spins between the c axis and the a b plane.

Scattering by a groove in an impedance plane

NASA Technical Reports Server (NTRS)

Bindiganavale, Sunil; Volakis, John L.

1993-01-01

An analysis of two-dimensional scattering from a narrow groove in an impedance plane is presented. The groove is represented by a impedance surface and the problem reduces to that of scattering from an impedance strip in an otherwise uniform impedance plane. On the basis of this model, appropriate integral equations are constructed using a form of the impedance plane Green's functions involving rapidly convergent integrals. The integral equations are solved by introducing a single basis representation of the equivalent current on the narrow impedance insert. Both transverse electric (TE) and transverse magnetic (TM) polarizations are treated. The resulting solution is validated by comparison with results from the standard boundary integral method (BIM) and a high frequency solution. It is found that the presented solution for narrow impedance inserts can be used in conjunction with the high frequency solution for the characterization of impedance inserts of any given width.

S-Wave Dispersion Relations: Exact Left Hand E-Plane Discontinuity from the Born Series

NASA Technical Reports Server (NTRS)

Bessis, D.; Temkin, A.

1999-01-01

We show, for a superposition of Yukawa potentials, that the left hand cut discontinuity in the complex E plane of the (S-wave) scattering amplitude is given exactly, in an interval depending on n, by the discontinuity of the Born series stopped at order n. This also establishes an inverse and unexpected correspondence of the Born series at positive high energies and negative low energies. We can thus construct a viable dispersion relation (DR) for the partial (S-) wave amplitude. The high numerical precision achievable by the DR is demonstrated for the exponential potential at zero scattering energy. We also briefly discuss the extension of our results to Field Theory.

Tm:GGAG crystal for 2μm tunable diode-pumped laser

NASA Astrophysics Data System (ADS)

Šulc, Jan; Boháček, Pavel; Němec, Michal; Fibrich, Martin; Jelínková, Helena; Trunda, Bohumil; Havlák, Lubomír.; Jurek, Karel; Nikl, Martin

2016-04-01

The spectroscopy properties and wavelength tunability of diode pumped laser based on Tm-doped mixed gadolinium-gallium-aluminium garnet Gd3(GaxAl1-x)5O12 (Tm:GGAG) single crystal were investigated for the first time. The crystal was grown by Czochralski method in a slightly oxidative atmosphere using an iridium crucible. The tested Tm:GGAG sample was cut from the grown crystal boule perpendicularly to growth direction (c-axis). The composition of sample was determined using electron microprobe X-ray elemental analysis. For spectroscopy and laser experiments 3.5mm thick plane-parallel face-polished plate (without AR coatings) with composition Gd2.76Tm0.0736Ga2.67Al2.50O12 (2.67 at.% Tm/Gd) was used. A fiber (core diameter 400 μm, NA= 0.22) coupled laser diode (emission wavelength 786 nm) was used for longitudinal Tm:GGAG pumping. The laser diode was operating in the pulsed regime (10 ms pulse length, 10 Hz repetition rate, maximum power amplitude 18 W). The 145mm long semi-hemispherical laser resonator consisted of a flat pumping mirror (HR @ 1.8- 2.10 μm, HT @ 0.78 μm) and curved (r = 150mm) output coupler with a reflectivity of » 97% @ 1.8- 2.10 µm. The maximum laser output power amplitude 1.14W was obtained at wavelength 2003nm for absorbed pump power amplitude 4.12W. The laser slope efficiency was 37% in respect to absorbed pumping power. Wavelength tuning was accomplished by using 2mm thick MgF2 birefringent filter placed inside the laser resonator at the Brewster angle. The laser was continuously tunable over 180nm in a spectral region from 1856nm to 2036 nm.

Validity of the paraxial approximation for electron acceleration with radially polarized laser beams.

PubMed

Marceau, Vincent; Varin, Charles; Piché, Michel

2013-03-15

In the study of laser-driven electron acceleration, it has become customary to work within the framework of paraxial wave optics. Using an exact solution to the Helmholtz equation as well as its paraxial counterpart, we perform numerical simulations of electron acceleration with a high-power TM(01) beam. For beam waist sizes at which the paraxial approximation was previously recognized valid, we highlight significant differences in the angular divergence and energy distribution of the electron bunches produced by the exact and the paraxial solutions. Our results demonstrate that extra care has to be taken when working under the paraxial approximation in the context of electron acceleration with radially polarized laser beams.

What Is the Reference? An Examination of Alternatives to the Reference Sources Used in IES TM-30-15

DOE Office of Scientific and Technical Information (OSTI.GOV)

Royer, Michael P.

A study was undertaken to document the role of the reference illuminant in the IES TM-30-15 method for evaluating color rendition. TM-30-15 relies on a relative reference scheme; that is, the reference illuminant and test source always have the same correlated color temperature (CCT). The reference illuminant is a Planckian radiator, model of daylight, or combination of those two, depending on the exact CCT of the test source. Three alternative reference schemes were considered: 1) either using all Planckian radiators or all daylight models; 2) using only one of ten possible illuminants (Planckian, daylight, or equal energy), regardless of themore » CCT of the test source; 3) using an off-Planckian reference illuminant (i.e., a source with a negative Duv). No reference scheme is inherently superior to another, with differences in metric values largely a result of small differences in gamut shape of the reference alternatives. While using any of the alternative schemes is more reasonable in the TM-30-15 evaluation framework than it was with the CIE CRI framework, the differences still ultimately manifest only as changes in interpretation of the results. References are employed in color rendering measures to provide a familiar point of comparison, not to establish an ideal source.« less

Communication: Recovering the flat-plane condition in electronic structure theory at semi-local DFT cost

NASA Astrophysics Data System (ADS)

Bajaj, Akash; Janet, Jon Paul; Kulik, Heather J.

2017-11-01

The flat-plane condition is the union of two exact constraints in electronic structure theory: (i) energetic piecewise linearity with fractional electron removal or addition and (ii) invariant energetics with change in electron spin in a half filled orbital. Semi-local density functional theory (DFT) fails to recover the flat plane, exhibiting convex fractional charge errors (FCE) and concave fractional spin errors (FSE) that are related to delocalization and static correlation errors. We previously showed that DFT+U eliminates FCE but now demonstrate that, like other widely employed corrections (i.e., Hartree-Fock exchange), it worsens FSE. To find an alternative strategy, we examine the shape of semi-local DFT deviations from the exact flat plane and we find this shape to be remarkably consistent across ions and molecules. We introduce the judiciously modified DFT (jmDFT) approach, wherein corrections are constructed from few-parameter, low-order functional forms that fit the shape of semi-local DFT errors. We select one such physically intuitive form and incorporate it self-consistently to correct semi-local DFT. We demonstrate on model systems that jmDFT represents the first easy-to-implement, no-overhead approach to recovering the flat plane from semi-local DFT.

Transformation formulas relating geodetic coordinates to a tangent to Earth, plane coordinate system

NASA Technical Reports Server (NTRS)

Credeur, L.

1981-01-01

Formulas and their approximation were developed to map geodetic position to an Earth tangent plane with an airport centered rectangular coordinate system. The transformations were developed for use in a terminal area air traffic model with deterministic aircraft traffic. The exact configured vehicle's approximation equations used in their precision microwave landing system navigation experiments.

Optical properties of transiently-excited semiconductor hyperbolic metamaterials

DOE PAGES

Campione, Salvatore; Luk, Ting S.; Liu, Sheng; ...

2015-10-02

Ultrafast optical excitation of photocarriers has the potential to transform undoped semiconductor superlattices into semiconductor hyperbolic metamaterials (SHMs). In this paper, we investigate the optical properties associated with such ultrafast topological transitions. We first show reflectance, transmittance, and absorption under TE and TM plane wave incidence. In the unpumped state, the superlattice exhibits a frequency region with high reflectance (>80%) and a region with low reflectance (<1%) for both TE and TM polarizations over a wide range of incidence angles. In contrast, in the photopumped state, the reflectance for both frequencies and polarizations is very low (<1%) for a similarmore » range of angles. Interestingly, this system can function as an all-optical reflection switch on ultrafast timescales. Furthermore, for TM incidence and close to the epsilon-near-zero point of the longitudinal permittivity, directional perfect absorption on ultrafast timescales may also be achieved. Lastly, we discuss the onset of negative refraction in the photopumped state.« less

Electrostatics of a Point Charge between Intersecting Planes: Exact Solutions and Method of Images

ERIC Educational Resources Information Center

Mei, W. N.; Holloway, A.

2005-01-01

In this work, the authors present a commonly used example in electrostatics that could be solved exactly in a conventional manner, yet expressed in a compact form, and simultaneously work out special cases using the method of images. Then, by plotting the potentials and electric fields obtained from these two methods, the authors demonstrate that…

Sets meeting isometric copies of the lattice Z2 in exactly one point

PubMed Central

Jackson, Steve; Mauldin, R. Daniel

2002-01-01

The construction of a subset S of ℝ2 such that each isometric copy of ℤ2 (the lattice points in the plane) meets S in exactly one point is indicated. This provides a positive answer to a problem of H. Steinhaus [Sierpiński, W. (1958) Fund. Math. 46, 191–194]. PMID:12466499

How hairpin vortices emerge from exact invariant solutions

NASA Astrophysics Data System (ADS)

Schneider, Tobias M.; Farano, Mirko; de Palma, Pietro; Robinet, Jean-Christoph; Cherubini, Stefania

2017-11-01

Hairpin vortices are among the most commonly observed flow structures in wall-bounded shear flows. However, within the dynamical system approach to turbulence, those structures have not yet been described. They are not captured by known exact invariant solutions of the Navier-Stokes equations nor have other state-space structures supporting hairpins been identified. We show that hairpin structures are observed along an optimally growing trajectory leaving a well known exact traveling wave solution of plane Poiseuille flow. The perturbation triggering hairpins does not correspond to an unstable mode of the exact traveling wave but lies in the stable manifold where non-normality causes strong transient amplification.

Bibliography of NRL Publications--1988

DTIC Science & Technology

1990-10-31

2749-2752 Free-Electron Laser , by Schuetz. L.S., Ott, E., and Antonsen, T.M., Physics of Fluids Exact but Computationally Intensive Predictions 0 31...Chemistry. 92:1200-1203, 1988 pp. 212-225 Reactions of Carbon Cluster Ions with Small Picosecond and Nanosecond Laser Photolyses of Hydrocarbons, by...Temperature Superconductors, by Ramnaker, The Study of Cluster Ions by Combined D.E., Turner. N.H.. and Hutson, F.L. ,* Physical Laser /Mass Spectrometry

Gaussian and Airy wave packets of massive particles with orbital angular momentum

NASA Astrophysics Data System (ADS)

Karlovets, Dmitry V.

2015-01-01

While wave-packet solutions for relativistic wave equations are oftentimes thought to be approximate (paraxial), we demonstrate, by employing a null-plane- (light-cone-) variable formalism, that there is a family of such solutions that are exact. A scalar Gaussian wave packet in the transverse plane is generalized so that it acquires a well-defined z component of the orbital angular momentum (OAM), while it may not acquire a typical "doughnut" spatial profile. Such quantum states and beams, in contrast to the Bessel states, may have an azimuthal-angle-dependent probability density and finite uncertainty of the OAM, which is determined by the packet's width. We construct a well-normalized Airy wave packet, which can be interpreted as a one-particle state for a relativistic massive boson, show that its center moves along the same quasiclassical straight path, and, which is more important, spreads with time and distance exactly as a Gaussian wave packet does, in accordance with the uncertainty principle. It is explained that this fact does not contradict the well-known "nonspreading" feature of the Airy beams. While the effective OAM for such states is zero, its uncertainty (or the beam's OAM bandwidth) is found to be finite, and it depends on the packet's parameters. A link between exact solutions for the Klein-Gordon equation in the null-plane-variable formalism and the approximate ones in the usual approach is indicated; generalizations of these states for a boson in the external field of a plane electromagnetic wave are also presented.

Characterization of radiometric calibration of LANDSAT-4 TM reflective bands

NASA Technical Reports Server (NTRS)

Barker, J. L.; Abrams, R. B.; Ball, D. L.; Leung, K. C.

1984-01-01

Prelaunch and postlaunch internal calibrator, image, and background data is to characterize the radiometric performance of the LANDSAT-4 TM and to recommend improved procedures for radiometric calibration. All but two channels (band 2, channel 4; band 5, channel 3) behave normally. Gain changes relative to a postlaunch reference for channels within a band vary within 0.5 percent as a group. Instrument gain for channels in the cold focal plane oscillates. Noise in background and image data ranges from 0.5 to 1.7 counts. Average differences in forward and reverse image data indicate a need for separate calibration processing of forward and reverse scans. Precision is improved by increasing the pulse integration width from 31 to 41 minor frames, depending on the band.

Spectrally resolved far-fields of terahertz quantum cascade lasers.

PubMed

Brandstetter, Martin; Schönhuber, Sebastian; Krall, Michael; Kainz, Martin A; Detz, Hermann; Zederbauer, Tobias; Andrews, Aaron M; Strasser, Gottfried; Unterrainer, Karl

2016-10-31

We demonstrate a convenient and fast method to measure the spectrally resolved far-fields of multimode terahertz quantum cascade lasers by combining a microbolometer focal plane array with an FTIR spectrometer. Far-fields of fundamental TM0 and higher lateral order TM1 modes of multimode Fabry-Pérot type lasers have been distinguished, which very well fit to the results obtained by a 3D finite-element simulation. Furthermore, multimode random laser cavities have been investigated, analyzing the contribution of each single laser mode to the total far-field. The presented method is thus an important tool to gain in-depth knowledge of the emission properties of multimode laser cavities at terahertz frequencies, which become increasingly important for future sensing applications.

Topology-optimized broadband surface relief transmission grating

NASA Astrophysics Data System (ADS)

Andkjær, Jacob; Ryder, Christian P.; Nielsen, Peter C.; Rasmussen, Thomas; Buchwald, Kristian; Sigmund, Ole

2014-03-01

We propose a design methodology for systematic design of surface relief transmission gratings with optimized diffraction efficiency. The methodology is based on a gradient-based topology optimization formulation along with 2D frequency domain finite element simulations for TE and TM polarized plane waves. The goal of the optimization is to find a grating design that maximizes diffraction efficiency for the -1st transmission order when illuminated by unpolarized plane waves. Results indicate that a surface relief transmission grating can be designed with a diffraction efficiency of more than 40% in a broadband range going from the ultraviolet region, through the visible region and into the near-infrared region.

FIBER AND INTEGRATED OPTICS: Noncollinear geometry for highly efficient excitation of a corrugated waveguide

NASA Astrophysics Data System (ADS)

Klimov, M. S.; Sychugov, V. A.; Tishchenko, A. V.

1992-02-01

An analysis is made of the process of light emission from a corrugated waveguide into air and into a substrate in a noncollinear geometry, i.e., when the direction along which the waveguide mode propagates does not coincide with the plane in which the emitted wave lies. Calculations show that when a TE mode is excited in a corrugated waveguide by a light beam with the TM polarization incident from air on the waveguide at a grazing angle, one can achieve a high waveguide excitation efficiency (~ 60%) if the waveguide mode propagates along the normal to the plane of incidence.

Development of Curved-Plate Elements for the Exact Buckling Analysis of Composite Plate Assemblies Including Transverse-Shear Effects

NASA Technical Reports Server (NTRS)

McGowan, David M.

1999-01-01

The analytical formulation of curved-plate non-linear equilibrium equations including transverse-shear-deformation effects is presented. A unified set of non-linear strains that contains terms from both physical and tensorial strain measures is used. Linearized, perturbed equilibrium equations (stability equations) that describe the response of the plate just after buckling occurs are derived. These equations are then modified to allow the plate reference surface to be located a distance z(sub c) from the centroidal surface. The implementation of the new theory into the VICONOPT exact buckling and vibration analysis and optimum design computer program is described. The terms of the plate stiffness matrix using both classical plate theory (CPT) and first-order shear-deformation plate theory (SDPT) are presented. The effects of in-plane transverse and in-plane shear loads are included in the in-plane stability equations. Numerical results for several example problems with different loading states are presented. Comparisons of analyses using both physical and tensorial strain measures as well as CPT and SDPT are made. The computational effort required by the new analysis is compared to that of the analysis currently in the VICONOPT program. The effects of including terms related to in-plane transverse and in-plane shear loadings in the in-plane stability equations are also examined. Finally, results of a design-optimization study of two different cylindrical shells subject to uniform axial compression are presented.

Segmental Versican Expression in the Trabecular Meshwork and Involvement in Outflow Facility

PubMed Central

Keller, Kate E.; Bradley, John M.; Vranka, Janice A.

2011-01-01

Purpose. Versican is a large proteoglycan with numerous chondroitin sulfate (CS) glycosaminoglycan (GAG) side chains attached. To assess versican's potential contributions to aqueous humor outflow resistance, its segmental distribution in the trabecular meshwork (TM) and the effect on outflow facility of silencing the versican gene were evaluated. Methods. Fluorescent quantum dots (Qdots) were perfused to label outflow pathways of anterior segments. Immunofluorescence with confocal microscopy and quantitative RT-PCR were used to determine versican protein and mRNA distribution relative to Qdot-labeled regions. Lentiviral delivery of shRNA-silencing cassettes to TM cells in perfused anterior segment cultures was used to evaluate the involvement of versican and CS GAG chains in outflow facility. Results. Qdot uptake by TM cells showed considerable segmental variability in both human and porcine outflow pathways. Regional levels of Qdot labeling were inversely related to versican protein and mRNA levels; versican levels were relatively high in sparsely Qdot-labeled regions and low in densely labeled regions. Versican silencing decreased outflow facility in human and increased facility in porcine anterior segments. However, RNAi silencing of ChGn, an enzyme unique to CS GAG biosynthesis, increased outflow facility in both species. The fibrillar pattern of versican immunostaining in the TM juxtacanalicular region was disrupted after versican silencing in perfusion culture. Conclusions. Versican appears to be a central component of the outflow resistance, where it may organize GAGs and other ECM components to facilitate and control open flow channels in the TM. However, the exact molecular organization of this resistance appears to differ between human and porcine eyes. PMID:21596823

Structure, magnetism, and transport of single-crystalline R NiSi3 (R = Y, Gd-Tm, Lu)

NASA Astrophysics Data System (ADS)

Arantes, Fabiana R.; Aristizábal-Giraldo, Deisy; Masunaga, Sueli H.; Costa, Fanny N.; Ferreira, Fabio F.; Takabatake, Toshiro; Mendonça-Ferreira, Leticie; Ribeiro, Raquel A.; Avila, Marcos A.

2018-04-01

We report on the physical properties of the intermetallic series R NiSi3 (R =Y , Gd-Tm, Lu). High quality single crystals with platelike morphology were grown using the Sn flux method. X-ray powder diffraction data show that this series crystallizes in the orthorhombic space group Cmmm, and Laue patterns indicate that the b axis remains perpendicular to the plane of the plates. Magnetization measurements show anisotropic antiferromagnetic ground states for R = Gd-Tm with Néel temperatures ranging from TN=2.6 K (TmNiSi3) up to 32.2 K (TbNiSi3), as well as metamagnetic transitions that in some cases appear together with hysteresis (TbNiSi3,DyNiSi3, and HoNiSi3). The easy axis changes from a axis to b axis on going from R = Gd-Ho to R = Er-Tm. All transitions from antiferromagnetic to paramagnetic states are clearly marked by sharp peaks in specific heat as well as in the derivative of resistivity measurements, which show metallic temperature dependence for all compounds and residual values in the range of 1 μ Ω cm . DyNiSi3 has two close phase transitions, while HoNiSi3 presents distinct critical temperatures for applied fields in the a or c directions (10.4 and 6.3 K, respectively), pointing to possible component-specific ordering of the local magnetic moments.

Gigantic perpendicular magnetic anisotropy of heavy transition metal cappings on Fe/MgO(0 0 1)

NASA Astrophysics Data System (ADS)

Taivansaikhan, P.; Odkhuu, D.; Rhim, S. H.; Hong, S. C.

2017-11-01

Effects of capping layer by 5d transition metals (TM = Hf, Ta, W, Re, Os, Ir, Pt, and Au) on Fe/MgO(0 0 1), a typical magnetic tunneling junction, are systematically investigated using first-principles calculation for magnetism and magnetocrystalline-anisotropy (MCA). The early TMs having less than half-filled d bands favor magnetization antiparallel to Fe, whereas the late TMs having more than half-filled d bands favor parallel, which is explained in the framework of kinetic exchange energy. The Os capping, isovalent to Fe, enhances MCA significantly to gigantic energy of +11.31 meV/cell, where positive contribution is mostly from the partially filled majority d bands of magnetic quantum number of |m| = 1 along with stronger spin-orbit coupling of Os than Fe. Different TM cappings give different MCA energies as the Fermi level shifts according to the valence of TM: Re and Ir, just one valence more or less than Os, have still large PMCA but smaller than the Os. In the W and Pt cappings, valence difference by two, PMCA are further reduced; MCAs are lowered compared to Fe/MgO(0 0 1) by the cappings of the very early TMs (Hf and Ta), while the very late TM (Au) switches sign to in-plane MCA.

Light propagation in nanorod arrays

NASA Astrophysics Data System (ADS)

Rahachou, A. I.; Zozoulenko, I. V.

2007-03-01

We study the propagation of TM- and TE-polarized light in two-dimensional arrays of silver nanorods of various diameters in a gelatin background. We calculate the transmittance, reflectance and absorption of arranged and disordered nanorod arrays and compare the exact numerical results with the predictions of the Maxwell-Garnett effective-medium theory. We show that interactions between nanorods, multipole contributions and formations of photonic gaps affect strongly the transmittance spectra that cannot be accounted for in terms of the conventional effective-medium theory. We also demonstrate and explain the degradation of the transmittance in arrays with randomly located rods as well as the weak influence of their fluctuating diameter. For TM modes we outline the importance of the skin effect, which causes the full reflection of the incoming light. We then illustrate the possibility of using periodic arrays of nanorods as high-quality polarizers.

Structure and ion channel activity of the human respiratory syncytial virus (hRSV) small hydrophobic protein transmembrane domain

PubMed Central

Gan, Siok Wan; Ng, Lifang; Lin, Xin; Gong, Xiandi; Torres, Jaume

2008-01-01

The small hydrophobic (SH) protein from the human respiratory syncytial virus (hRSV) is a glycoprotein of ∼64 amino acids with one putative α-helical transmembrane domain. Although SH protein is important for viral infectivity, its exact role during viral infection is not clear. Herein, we have studied the secondary structure, orientation, and oligomerization of the transmembrane domain of SH (SH-TM) in the presence of lipid bilayers. Only one oligomer, a pentamer, was observed in PFO-PAGE. Using polarized attenuated total reflection-Fourier transform infrared (PATR-FTIR) spectroscopy, we show that the SH-TM is α-helical. The rotational orientation of SH-TM was determined by site-specific infrared dichroism (SSID) at two consecutive isotopically labeled residues. This orientation is consistent with that of an evolutionary conserved pentameric model obtained from a global search protocol using 13 homologous sequences of RSV. Conductance studies of SH-TM indicate ion channel activity, which is cation selective, and inactive below the predicted pKa of histidine. Thus, our results provide experimental evidence that the transmembrane domain of SH protein forms pentameric α-helical bundles that form cation-selective ion channels in planar lipid bilayers. We provide a model for this pore, which should be useful in mutagenesis studies to elucidate its role during the virus cycle. PMID:18369195

Comment on "Collision of plane gravitational waves without singularities"

NASA Astrophysics Data System (ADS)

Nutku, Y.

1981-08-01

An incorrect paper was published by B. J. Stoyanov carrying the title above. Here we shall point out a coordinate transformation whereby "the new exact solution" of his paper is recognized as a Kasner universe. Further, we shall show that Stoyanov's interpretation of the Kasner solution as colliding plane gravitational waves runs into the difficulty that the Einstein field equations are not satisfied everywhere.

Comment on ''Collision of plane gravitational waves without singularities''

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nutku, Y.

1981-08-15

An incorrect paper was published by B. J. Stoyanov carrying the title above. Here we shall point out a coordinate transformation whereby ''the new exact solution'' of his paper is recognized as a Kasner universe. Further, we shall show that Stoyanov's interpretation of the Kasner solution as colliding plane gravitational waves runs into the difficulty that the Einstein field equations are not satisfied everywhere.

Some boundary-value problems for anisotropic quarter plane

NASA Astrophysics Data System (ADS)

Arkhypenko, K. M.; Kryvyi, O. F.

2018-04-01

To solve the mixed boundary-value problems of the anisotropic elasticity for the anisotropic quarter plane, a method based on the use of the space of generalized functions {\\Im }{\\prime }({\\text{R}}+2) with slow growth properties was developed. The two-dimensional integral Fourier transform was used to construct the system of fundamental solutions for the anisotropic quarter plane in this space and a system of eight boundary integral relations was obtained, which allows one to reduce the mixed boundary-value problems for the anisotropic quarter plane directly to systems of singular integral equations with fixed singularities. The exact solutions of these systems were found by using the integral Mellin transform. The asymptotic behavior of solutions was investigated at the vertex of the quarter plane.

Investigations of mechanical, electronic, and magnetic properties of non-magnetic MgTe and ferro-magnetic Mg0.75 TM 0.25Te (TM = Fe, Co, Ni): An ab-initio calculation

NASA Astrophysics Data System (ADS)

Q, Mahmood; S, M. Alay-e.-Abbas; I, Mahmood; Mahmood, Asif; N, A. Noor

2016-04-01

The mechanical, electronic and magnetic properties of non-magnetic MgTe and ferro-magnetic (FM) Mg0.75 TM 0.25Te (TM = Fe, Co, Ni) in the zinc-blende phase are studied by ab-initio calculations for the first time. We use the generalized gradient approximation functional for computing the structural stability, and mechanical properties, while the modified Becke and Johnson local (spin) density approximation (mBJLDA) is utilized for determining the electronic and magnetic properties. By comparing the energies of non-magnetic and FM calculations, we find that the compounds are stable in the FM phase, which is confirmed by their structural stabilities in terms of enthalpy of formation. Detailed descriptions of elastic properties of Mg0.75 TM 0.25Te alloys in the FM phase are also presented. For electronic properties, the spin-polarized electronic band structures and density of states are computed, showing that these compounds are direct bandgap materials with strong hybridizations of TM 3d states and Te p states. Further, the ferromagnetism is discussed in terms of the Zener free electron model, RKKY model and double exchange model. The charge density contours in the (110) plane are calculated to study bonding properties. The spin exchange splitting and crystal field splitting energies are also calculated. The distribution of electron spin density is employed in computing the magnetic moments appearing at the magnetic sites (Fe, Co, Ni), as well as at the non-magnetic sites (Mg, Te). It is found that the p-d hybridization causes not only magnetic moments on the magnetic sites but also induces negligibly small magnetic moments at the non-magnetic sites.

Bi-material plane with interface crack for the model of semi-linear material

NASA Astrophysics Data System (ADS)

Domanskaya, T. O.; Malkov, V. M.; Malkova, Yu. V.

2018-05-01

The singular plane problems of nonlinear elasticity (plane strain and plane stress) are considered for bi-material infinite plane with interface crack. The plane is formed of two half-planes. Mechanical properties of half-planes are described by the model of semi-linear material. Using model of this harmonic material has allowed to apply the theory of complex functions and to obtain exact analytical global solutions of some nonlinear problems. Among them the problem of bi-material plane with the stresses and strains jumps at an interface is considered. As an application of the problem of jumps, the problem of interface crack is solved. The values of nominal (Piola) and Cauchy stresses and displacements are founded. Based on the global solutions the asymptotic expansions are constructed for stresses and displacements in a vicinity of crack tip. As an example the case of a free crack in bi-material plane subjected to constant stresses at infinity is studied. As a special case, the analytical solution of the problem of a crack in a homogeneous plane is obtained from the problem for bi-material plane with interface crack.

Dirac cones in artificial structures of 3d transitional-metals doped Mg-Al spinels

NASA Astrophysics Data System (ADS)

Lu, Yuan; Feng, Min; Shao, Bin; Zuo, Xu

2014-05-01

Motivated by recent theoretical predications for Dirac cone in two-dimensional (2D) triangular lattice [H. Ishizuka, Phys. Rev. Lett. 109, 237207 (2012)], first-principles studies are performed to predict Dirac cones in artificial structures of 3d transitional-metals (TM = Ti, V, Cr, Mn, Fe, Co, Ni, and Cu) doped Mg-Al spinels. In investigated artificial structures, TM dopants substitute specific positions of the B sub-lattice in Mg-Al spinel, and form a quasi-2D triangular lattice in the a-b plane. Calculated results illustrate the existence of the spin-polarized Dirac cones formed in d-wave bands at (around) the K-point in the momentum space. The study provides a promising route for engineering Dirac physics in condensed matters.

Surface plasmon coupling for suppressing p-GaN absorption and TM-polarized emission in a deep-UV light-emitting diode.

PubMed

Kuo, Yang; Su, Chia-Ying; Hsieh, Chieh; Chang, Wen-Yen; Huang, Chu-An; Kiang, Yean-Woei; Yang, C C

2015-09-15

The radiated power enhancement (suppression) of an in- (out-of-) plane-oriented radiating dipole at a desired emission wavelength in the deep-ultraviolet (UV) range when it is coupled with a surface plasmon (SP) resonance mode induced on a nearby Al nanoparticle (NP) is demonstrated. Also, it is found that the enhanced radiated power propagates mainly in the direction from the Al NP toward the dipole. Such SP coupling behaviors can be used for suppressing the transverse-magnetic (TM)-polarized emission, enhancing the transverse-electric-polarized emission, and reducing the UV absorption of the p-GaN layer in an AlGaN-based deep-UV light-emitting diode by embedding a sphere-like Al NP in its p-AlGaN layer.

Worldline approach to helicity flip in plane waves

NASA Astrophysics Data System (ADS)

Ilderton, Anton; Torgrimsson, Greger

2016-04-01

We apply worldline methods to the study of vacuum polarization effects in plane wave backgrounds, in both scalar and spinor QED. We calculate helicity-flip probabilities to one loop order and treated exactly in the background field, and provide a toolkit of methods for use in investigations of higher-order processes. We also discuss the connections between the worldline, S-matrix, and lightfront approaches to vacuum polarization effects.

Electromagnetic MUSIC-type imaging of perfectly conducting, arc-like cracks at single frequency

NASA Astrophysics Data System (ADS)

Park, Won-Kwang; Lesselier, Dominique

2009-11-01

We propose a non-iterative MUSIC (MUltiple SIgnal Classification)-type algorithm for the time-harmonic electromagnetic imaging of one or more perfectly conducting, arc-like cracks found within a homogeneous space R2. The algorithm is based on a factorization of the Multi-Static Response (MSR) matrix collected in the far-field at a single, nonzero frequency in either Transverse Magnetic (TM) mode (Dirichlet boundary condition) or Transverse Electric (TE) mode (Neumann boundary condition), followed by the calculation of a MUSIC cost functional expected to exhibit peaks along the crack curves each half a wavelength. Numerical experimentation from exact, noiseless and noisy data shows that this is indeed the case and that the proposed algorithm behaves in robust manner, with better results in the TM mode than in the TE mode for which one would have to estimate the normal to the crack to get the most optimal results.

Interaction of Tenebrio Molitor Antifreeze Protein with Ice Crystal: Insights from Molecular Dynamics Simulations.

PubMed

Ramya, L; Ramakrishnan, Vigneshwar

2016-07-01

Antifreeze proteins (AFP) observed in cold-adapting organisms bind to ice crystals and prevent further ice growth. However, the molecular mechanism of AFP-ice binding and AFP-inhibited ice growth remains unclear. Here we report the interaction of the insect antifreeze protein (Tenebrio molitor, TmAFP) with ice crystal by molecular dynamics simulation studies. Two sets of simulations were carried out at 263 K by placing the protein near the primary prism plane (PP) and basal plane (BL) of the ice crystal. To delineate the effect of temperatures, both the PP and BL simulations were carried out at 253 K as well. The analyses revealed that the protein interacts strongly with the ice crystal in BL simulation than in PP simulation both at 263 K and 253 K. Further, it was observed that the interactions are primarily mediated through the interface waters. We also observed that as the temperature decreases, the interaction between the protein and the ice increases which can be attributed to the decreased flexibility and the increased structuring of the protein at low temperature. In essence, our study has shed light on the interaction mechanism between the TmAFP antifreeze protein and the ice crystal. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

ArF step-and-scan system with 0.75 NA for the 0.10μm node

NASA Astrophysics Data System (ADS)

Vleeming, Bert; Heskamp, Barbra; Bakker, Hans; Verstappen, Leon; Finders, Jo; Stoeten, Jan; Boerret, Rainer; Roempp, Oliver

2001-09-01

It is widely expected that 193 nm lithography will be the technology of choice for volume production of the 0.10 micrometer device generation. For this purpose the PAS5500/1100TM Step & Scan system, the second generation ArF tool, was developed. It is based on the PAS5500/900TM, the body of which has been adapted to fit the new 0.75 NA StarlithTM projection optics. This high NA enables mass manufacturing of devices following the 0.10 micrometer design rule. The system features a 10 W 2 kHz ArF laser and the AERIALTM II illuminator that can be equipped with a QUASARTM (multipole) option. In order to minimize wafer processing influences on overlay performance ATHENATM off- axis alignment with phase modulator is implemented. The usage of Reticle Blue Alignment will further improve overlay as well as increase the system stability. In this paper the PAS5500/1100TM system layout is discussed and the first imaging and overlay results are presented. Imaging performance is illustrated by SEM pictures of 0.10 micrometer dense lines, 0.15, 0.13 and 0.12 micrometer dense contact holes, 0.10 micrometer DRAM isolation patterns, image plane deviation and system distortion fingerprints. Alignment reproducibility and single machine overlay results demonstrate the overlay capability.

Asymptotic Distributions of Coalescence Times and Ancestral Lineage Numbers for Populations with Temporally Varying Size

PubMed Central

Chen, Hua; Chen, Kun

2013-01-01

The distributions of coalescence times and ancestral lineage numbers play an essential role in coalescent modeling and ancestral inference. Both exact distributions of coalescence times and ancestral lineage numbers are expressed as the sum of alternating series, and the terms in the series become numerically intractable for large samples. More computationally attractive are their asymptotic distributions, which were derived in Griffiths (1984) for populations with constant size. In this article, we derive the asymptotic distributions of coalescence times and ancestral lineage numbers for populations with temporally varying size. For a sample of size n, denote by Tm the mth coalescent time, when m + 1 lineages coalesce into m lineages, and An(t) the number of ancestral lineages at time t back from the current generation. Similar to the results in Griffiths (1984), the number of ancestral lineages, An(t), and the coalescence times, Tm, are asymptotically normal, with the mean and variance of these distributions depending on the population size function, N(t). At the very early stage of the coalescent, when t → 0, the number of coalesced lineages n − An(t) follows a Poisson distribution, and as m → n, n(n−1)Tm/2N(0) follows a gamma distribution. We demonstrate the accuracy of the asymptotic approximations by comparing to both exact distributions and coalescent simulations. Several applications of the theoretical results are also shown: deriving statistics related to the properties of gene genealogies, such as the time to the most recent common ancestor (TMRCA) and the total branch length (TBL) of the genealogy, and deriving the allele frequency spectrum for large genealogies. With the advent of genomic-level sequencing data for large samples, the asymptotic distributions are expected to have wide applications in theoretical and methodological development for population genetic inference. PMID:23666939

Exact solution of the generalized Peierls equation for arbitrary n-fold screw dislocation

NASA Astrophysics Data System (ADS)

Wang, Shaofeng; Hu, Xiangsheng

2018-05-01

The exact solution of the generalized Peierls equation is presented and proved for arbitrary n-fold screw dislocation. The displacement field, stress field and the energy of the n-fold dislocation are also evaluated explicitly. It is found that the solution defined on each individual fold is given by the tail cut from the original Peierls solution. In viewpoint of energetics, a screw dislocation has a tendency to spread the distribution on all possible slip planes which are contained in the dislocation line zone. Based on the exact solution, the approximated solution of the improved Peierls equation is proposed for the modified γ-surface.

Exact asymmetric Skyrmion in anisotropic ferromagnet and its helimagnetic application

NASA Astrophysics Data System (ADS)

Kundu, Anjan

2016-08-01

Topological Skyrmions as intricate spin textures were observed experimentally in helimagnets on 2d plane. Theoretical foundation of such solitonic states to appear in pure ferromagnetic model, as exact solutions expressed through any analytic function, was made long ago by Belavin and Polyakov (BP). We propose an innovative generalization of the BP solution for an anisotropic ferromagnet, based on a physically motivated geometric (in-)equality, which takes the exact Skyrmion to a new class of functions beyond analyticity. The possibility of stabilizing such metastable states in helimagnets is discussed with the construction of individual Skyrmion, Skyrmion crystal and lattice with asymmetry, likely to be detected in precision experiments.

Time-Harmonic Gaussian Beams: Exact Solutions of the Helmhotz Equation in Free Space

NASA Astrophysics Data System (ADS)

Kiselev, A. P.

2017-12-01

An exact solution of the Helmholtz equation u xx + u yy + u zz + k 2 u = 0 is presented, which describes propagation of monochromatic waves in the free space. The solution has the form of a superposition of plane waves with a specific weight function dependent on a certain free parameter a. If ka→∞, the solution is localized in the Gaussian manner in a vicinity of a certain straight line and asymptotically coincides with the famous approximate solution known as the fundamental mode of a paraxial Gaussian beam. The asymptotics of the aforementioned exact solution does not include a backward wave.

Traveling with children

MedlinePlus

... recent medical reports and a list of all medicines your child is taking. PLANES, TRAINS, BUSES Bring snacks and ... landing. Follow package instructions exactly about how much medicine to give your child. Ask your doctor before using cold medicines that ...

Development of Curved-Plate Elements for the Exact Buckling Analysis of Composite Plate Assemblies Including Transverse-Shear Effects

NASA Technical Reports Server (NTRS)

McGowan, David Michael

1997-01-01

The analytical formulation of curved-plate non-linear equilibrium equations including transverse-shear-deformation effects is presented. The formulation uses the principle of virtual work. A unified set of non-linear strains that contains terms from both physical and tensorial strain measures is used. Linearized, perturbed equilibrium equations (stability equations) that describe the response of the plate just after buckling occurs are then derived after the application of several simplifying assumptions. These equations are then modified to allow the reference surface of the plate to be located at a distance z(sub c) from the centroidal surface. The implementation of the new theory into the VICONOPT exact buckling and vibration analysis and optimum design computer program is described as well. The terms of the plate stiffness matrix using both Classical Plate Theory (CPT) and first-order Shear-Deformation Plate Theory (SDPT) are presented. The necessary steps to include the effects of in-plane transverse and in-plane shear loads in the in-plane stability equations are also outlined. Numerical results are presented using the newly implemented capability. Comparisons of results for several example problems with different loading states are made. Comparisons of analyses using both physical and tensorial strain measures as well as CPT and SDPF are also made. Results comparing the computational effort required by the new analysis to that of the analysis currently in the VICONOPT program are presented. The effects of including terms related to in-plane transverse and in-plane shear loadings in the in-plane stability equations are also examined. Finally, results of a design-optimization study of two different cylindrical shells subject to uniform axial compression are presented.

An investigation of CO2 laser scleral buckling using moiré interferometry.

PubMed

Maswadi, Saher M; Dyer, Peter E; Verma, Dinesh; Jalabi, Wadah; Dave, Dinesh

2002-01-01

To demonstrate suitability of moiré interferometry to assess and quantify laser-induced shrinkage of scleral collagen for buckling procedures. Scleral buckling of human cadaver eyes was investigated using a Coherent Ultrapulse CO2 laser. Projection moiré interferometry was employed to determine the out-of plane displacement produced by laser exposure, and in-situ optical microscopy of reference markers on the eye was used to measure in-plane shrinkage. Measurements based on moiré interferometry allow a three dimensional view of shape changes in the eye surface as laser treatment proceeds. Out-of-plane displacement reaches up to 1.5 mm with a single laser spot exposure. In-plane shrinkage reached a maximum of around 30%, which is similar to that reported by Sasoh et al (Ophthalmic Surg Lasers. 1998;29:410) for a Tm:YAG laser. The moiré technique is found to be suitable for quantifying the effects of CO2 laser scleral shrinkage and buckling. This can be further developed to provide a standardized method for experimental investigations of other laser sources for scleral shrinkage.

Magma reservoir subsidence mechanics: Theoretical summary and application to Kilauea Volcano, Hawaii

NASA Astrophysics Data System (ADS)

Ryan, Michael P.; Blevins, James Y. K.; Okamura, Arnold T.; Koyanagi, Robert Y.

1983-05-01

An analytic model has been developed for the prediction of the three-dimensional deformation field generated by the withdrawal of magma from a sill-like storage compartment during an intrusion or eruption cycle. The model is based on the work of Berry and Sales (1961, 1962) and predicts the vertical displacement components over the areal plane. Model parameters are the depth of burial h, the intrusion half width a, the intrusion half length b, the thickness of the magmatic interior at the moment of melt withdrawal tm, and the planform aspect ratio ξ = a/b. The products of the model include areal deformation maps. Systematic variation in model parameters within the context of Kilauea Volcano, Hawaii, have revealed that circular and elliptical deformation patterns result from the collapse of draining rectilinear intrusions at depth. Moreover, the geometric parameters of a storage compartment may interact in complex ways to produce similar deformation patterns. The model has been applied to Kilauea Volcano for three periods of pronounced summit subsidence: (1) 1921-1927 (bracketing the steamblast eruptive phases of 1924); (2) June 1972 to December 1972, and (3) December 1972 to May 1973. Application of the model requires the simultaneous optimization of five predicted deformation features with respect to field measurements and the derivative deformation maps: (1) the vertical displacement maxima; (2) the vertical displacement gradients over the areal plane, (3) the lateral extent of the deformation field, (4) the aspect ratio of the subsidence pattern, and (5) the strike of the major axis of the deformation field. The constrained geometries and volumes of the inferred collapsed storage cavities for each period are (1) 1921-1927: depth ≅ 3 km, a ≅ 1500 m, b ≅ 4500 m, tm ≅ 20 m, V 540×106 m3, (2) June 1972 to December 1972: depth ≅ 3.3 km, a ≅ 600 m, b ≅ 2000 m, tm ≅ 1 m, V ≅ 4.8×106 m3, and (3) December 1972 to May 1973: depth ≅ 2.2 km, a ≅ 500 m, b ≅ 1612 m, tm ≅ 1 m, V ≅ 3.2×106 m3. For 2 and 3, calculated magmatic thicknesses tm happen to be in the range (3.48-0.15 m) of measurements for sill-like bodies in deeply dissected Hawaiian shield volcanoes. The fits obtained between calculated and observed deformation patterns allow quantification of the location, overall dimensions, orientation, and volume of the discrete, still molten, interior of sill-like compartments from which magma is tapped during eruption or intrusion.

[Histological structure of the trabecular meshwork in the eyeball: challenging the traditional concept and preliminary findings in rabbits, rats and mice].

PubMed

Shi, Yun; Zhou, Fan-Qi; Luo, Zhou-Cai; Chen, Ying-Hua; Chen, Yu; Dong, Wei-Ren

2017-10-20

To verify that the trabecular meshwork (TM) in the wall of the eyeball consists of smooth muscle fibers instead of collagen fibers or endothelial cells. Eighteen fresh eyeballs from 3 rabbits, 3 SD rats and 3 mice were sectioned along the sagittal plane and sliced after paraffin embedding for HE staining, VG staining, Masson staining, α-SMA immunohistochemistry or CD31 immunohistochemistry. These slices were observed under microscope and the structure of the TM was compared with those of scleral collagen fibers, ciliary muscles and endothelial cells. HE staining of the eyeball slices from the 3 animal species resulted in purplish red staining of the TM, which was highly consistent with ciliary muscle fibers. The cell?like structures on the surface of the TM were not clearly outlined, with flat nuclei showing a dark purple staining; these structures did not show obvious boundaries from the TM. Ciliary muscle fibers, which were smooth muscle cells in nature, were aligned in bundles in various directions. The longitudinally sectioned cells were flat and contained purplish cytoplasm and highly flattened nuclei. Scleral collagen fibers were stained dark red with a few fibroblasts sandwiched among them. The long axis of the fibroblasts was in parallel with that of the collagen fibers. The outline of the fibroblast was not clear and the nucleus was flat in dark blue. The vascular endothelial cells presented with different morphologies and contained light purplish cytoplasm and dark nuclei, protruding into the vascular cavity. VG staining of the TM revealed a pale red filamentous structure, and the collagen fibers were stained bright red. Masson staining of the TM showed a reticular structure consisting mainly of dark red fibers intermingled with thin green fibers. Scleral collagen fibers presented with a cord?like green wavy structure. The endothelial cells were green and flat, while the ciliary smooth muscle fibers were purple. In immunohistochemistry for α?SMA, the TM and the ciliary smooth muscle fibers showed a strong positivity in the cytoplasm, while the scleral collagen fibers and vascular endothelial cells showed negative staining; immunohistochemistry for CD31 showed no obvious positive staining in the TM, collagen fibers or ciliary smooth muscle cells from all the animals in spite of slight differences among them. The TM consists mainly of smooth muscle fibers with a thin layer of peripheral endomysium without endothelial cells.

Extinction properties of single-walled carbon nanotubes: Two-fluid model

DOE Office of Scientific and Technical Information (OSTI.GOV)

Moradi, Afshin, E-mail: a.moradi@kut.ac.ir

The extinction spectra of a single-walled carbon nanotube are investigated, within the framework of the vector wave function method in conjunction with the hydrodynamic model. Both polarizations of the incident plane wave (TE and TM with respect to the x-z plane) are treated. Electronic excitations on the nanotube surface are modeled by an infinitesimally thin layer of a two-dimensional electron gas represented by two interacting fluids, which takes into account the different nature of the σ and π electrons. Numerical results show that strong interaction between the fluids gives rise to the splitting of the extinction spectra into two peaksmore » in quantitative agreement with the π and σ + π plasmon energies.« less

Dielectric Covered Planar Antennas

NASA Technical Reports Server (NTRS)

Llombart Juan, Nuria (Inventor); Lee, Choonsup (Inventor); Chattopadhyay, Goutam (Inventor); Gill, John J. (Inventor); Skalare, Anders J. (Inventor); Siegel, Peter H. (Inventor)

2014-01-01

An antenna element suitable for integrated arrays at terahertz frequencies is disclosed. The antenna element comprises an extended spherical (e.g. hemispherical) semiconductor lens, e.g. silicon, antenna fed by a leaky wave waveguide feed. The extended spherical lens comprises a substantially spherical lens adjacent a substantially planar lens extension. A couple of TE/TM leaky wave modes are excited in a resonant cavity formed between a ground plane and the substantially planar lens extension by a waveguide block coupled to the ground plane. Due to these modes, the primary feed radiates inside the lens with a directive pattern that illuminates a small sector of the lens. The antenna structure is compatible with known semiconductor fabrication technology and enables production of large format imaging arrays.

Plane Symmetric Solutions in f(G) Gravity

NASA Astrophysics Data System (ADS)

Shamir, M. Farasat; Saeed, Atrooba

2017-12-01

The purpose of this document is to investigate the universe in f(G) gravity. A wgeneral static plane symmetric space-time is chosen and exact solutions are explored using a viable f(G) gravity model. In particular, power and exponential law solutions are discussed. In addition, the physical relevance of the solutions with Taub's metric and anti-deSitter space-time is shown. Graphical analysis of energy density and pressure of the universe is done to substantiate the study.

Dynamical analysis of a cubic Liénard system with global parameters

NASA Astrophysics Data System (ADS)

Chen, Hebai; Chen, Xingwu

2015-10-01

In this paper we investigate the dynamical behaviour of a cubic Liénard system with global parameters. After analysing the qualitative properties of all the equilibria and judging the existences of limit cycles and homoclinic loops for the whole parameter plane, we give the bifurcation diagram and phase portraits. Phase portraits are global if there exist limit cycles and local otherwise. We prove that parameters lie in a connected region, not just on a curve, usually in the parameter plane when the system has one homoclinic loop. Moreover, for global parameters we give a positive answer to conjecture 3.2 of (1998 Nonlinearity 11 1505-19) in the case of exactly two equilibria about the existence of some function whose graph is exactly the surface of double limit cycles. Supported by NSFC 11471228, 11172246 and the Fundamental Research Funds for the Central Universities.

Analytical solution for boundary heat fluxes from a radiating rectangular medium

NASA Technical Reports Server (NTRS)

Siegel, R.

1991-01-01

Reference is made to the work of Shah (1979) which demonstrated the possibility of partially integrating the radiative equations analytically to obtain an 'exact' solution. Shah's solution was given as a double integration of the modified Bessel function of order zero. Here, it is shown that the 'exact' solution for a rectangular region radiating to cold black walls can be conveniently derived, and expressed in simple form, by using an integral function, Sn, analogous to the exponential integral function appearing in plane-layer solutions.

Stability of landsat-4 thematic mapper outgassing models

USGS Publications Warehouse

Micijevic, E.; Chander, G.

2006-01-01

Oscillations in radiometric gains of the short wave infrared (SWIR) bands in Landsat-4 (L4) and Landsat-5 (L5) Thematic Mappers (TMs) are observed through an analysis of detector responses to the Internal Calibrator (IC) pulses. The oscillations are believed to be caused by an interference effect due to a contaminant film buildup on the window of the cryogenically cooled dewar that houses these detectors. This process of contamination, referred to as outgassing effects, has been well characterized using an optical thin-film model that relates detector responses to the accumulated film thickness and its growth rate. The current models for L4 TM are based on average detector responses to the second brightest IC lamp and have been derived from three data sets acquired during different times throughout the instrument's lifetime. Unlike in L5 TM outgassing characterization, it was found that the L4 TM responses to all three IC lamps can be used to provide accurate characterization and correction for outgassing effects. The analysis of single detector responses revealed an up to five percent difference in the estimated oscillating periods and also indicated a gradual variation of contaminant growth rate over the focal plane.

Molecular-dynamics analysis of mobile helium cluster reactions near surfaces of plasma-exposed tungsten

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hu, Lin; Maroudas, Dimitrios, E-mail: maroudas@ecs.umass.edu; Hammond, Karl D.

We report the results of a systematic atomic-scale analysis of the reactions of small mobile helium clusters (He{sub n}, 4 ≤ n ≤ 7) near low-Miller-index tungsten (W) surfaces, aiming at a fundamental understanding of the near-surface dynamics of helium-carrying species in plasma-exposed tungsten. These small mobile helium clusters are attracted to the surface and migrate to the surface by Fickian diffusion and drift due to the thermodynamic driving force for surface segregation. As the clusters migrate toward the surface, trap mutation (TM) and cluster dissociation reactions are activated at rates higher than in the bulk. TM produces W adatoms and immobile complexes ofmore » helium clusters surrounding W vacancies located within the lattice planes at a short distance from the surface. These reactions are identified and characterized in detail based on the analysis of a large number of molecular-dynamics trajectories for each such mobile cluster near W(100), W(110), and W(111) surfaces. TM is found to be the dominant cluster reaction for all cluster and surface combinations, except for the He{sub 4} and He{sub 5} clusters near W(100) where cluster partial dissociation following TM dominates. We find that there exists a critical cluster size, n = 4 near W(100) and W(111) and n = 5 near W(110), beyond which the formation of multiple W adatoms and vacancies in the TM reactions is observed. The identified cluster reactions are responsible for important structural, morphological, and compositional features in the plasma-exposed tungsten, including surface adatom populations, near-surface immobile helium-vacancy complexes, and retained helium content, which are expected to influence the amount of hydrogen re-cycling and tritium retention in fusion tokamaks.« less

Periowave demonstrates bactericidal activity against periopathogens and leads to improved clinical outcomes in the treatment of adult periodontitis

NASA Astrophysics Data System (ADS)

Street, Cale N.; Andersen, Roger; Loebel, Nicolas G.

2009-02-01

Periodontitis affects half of the U.S. population over 50, and is the leading cause of tooth loss after 35. It is believed to be caused by growth of complex bacterial biofilms on the tooth surface below the gumline. Photodynamic therapy, a technology used commonly in antitumor applications, has more recently been shown to exhibit antimicrobial efficacy. We have demonstrated eradication of the periopathogens Porphyromonas gingivalis, Fusobacterium nucleatum, and Aggregatibacter actinomycetemcomitans in vitro using PeriowaveTM; a commercial photodisinfection system. In addition, several clinical studies have now demonstrated the efficacy of this treatment. A pilot study in the U.S. showed that 68% of patients treated with PeriowaveTM adjunctively to scaling and root planing (SRP) showed clinical attachment level increase of >1 mm, as opposed to 30% with SRP alone. In a subsequent larger study, a second PeriowaveTM treatment 6 weeks after initial treatment led to pocket depth improvements of >1.5 mm in 89% of patients. Finally, in the most recent multicenter, randomized, examiner-blinded study conducted on 121 subjects in Canada, PeriowaveTM treatment produced highly significant gains in attachment level (0.88 mm vs. 0.57 mm; p=0.003) and pocket depth (0.87 mm vs. 0.63 mm; p=0.01) as compared to SRP alone. In summary, PeriowaveTM demonstrated strong bactericidal activity against known periopathogens, and treatment of periodontitis using this system produced significantly better clinical outcomes than SRP alone. This, along with the absence of any adverse events in patients treated to date demonstrates that PDT is a safe and effective treatment for adult chronic periodontitis.

Small scale exact coherent structures at large Reynolds numbers in plane Couette flow

NASA Astrophysics Data System (ADS)

Eckhardt, Bruno; Zammert, Stefan

2018-02-01

The transition to turbulence in plane Couette flow and several other shear flows is connected with saddle node bifurcations in which fully three-dimensional, nonlinear solutions to the Navier-Stokes equation, so-called exact coherent states (ECS), appear. As the Reynolds number increases, the states undergo secondary bifurcations and their time-evolution becomes increasingly more complex. Their spatial complexity, in contrast, remains limited so that these states cannot contribute to the spatial complexity and cascade to smaller scales expected for higher Reynolds numbers. We here present families of scaling ECS that exist on ever smaller scales as the Reynolds number is increased. We focus in particular on two such families for plane Couette flow, one centered near the midplane and the other close to a wall. We discuss their scaling and localization properties and the bifurcation diagrams. All solutions are localized in the wall-normal direction. In the spanwise and downstream direction, they are either periodic or localized as well. The family of scaling ECS localized near a wall is reminiscent of attached eddies, and indicates how self-similar ECS can contribute to the formation of boundary layer profiles.

Exact coherent structures in an asymptotically reduced description of parallel shear flows

NASA Astrophysics Data System (ADS)

Beaume, Cédric; Knobloch, Edgar; Chini, Gregory P.; Julien, Keith

2015-02-01

A reduced description of shear flows motivated by the Reynolds number scaling of lower-branch exact coherent states in plane Couette flow (Wang J, Gibson J and Waleffe F 2007 Phys. Rev. Lett. 98 204501) is constructed. Exact time-independent nonlinear solutions of the reduced equations corresponding to both lower and upper branch states are found for a sinusoidal, body-forced shear flow. The lower branch solution is characterized by fluctuations that vary slowly along the critical layer while the upper branch solutions display a bimodal structure and are more strongly focused on the critical layer. The reduced equations provide a rational framework for investigations of subcritical spatiotemporal patterns in parallel shear flows.

A new class of exact solutions of the Klein-Gordon equation of a charged particle interacting with an electromagnetic plane wave in a medium

NASA Astrophysics Data System (ADS)

Varró, Sándor

2014-01-01

Exact solutions are presented of the Klein-Gordon equation of a charged particle moving in a transverse monochromatic plasmon wave of arbitrary high amplitude, which propagates in an underdense plasma. These solutions are expressed in terms of Ince polynomials, forming a doubly infinite set, parametrized by discrete momentum components of the charged particle’s de Broglie wave along the polarization vector and along the propagation direction of the plasmon radiation. The envelope of the exact wavefunctions describes a high-contrast periodic structure of the particle density on the plasma length scale, which may have relevance in novel particle acceleration mechanisms.

Cavity mode enhancement of terahertz emission from equilateral triangular microstrip antennas of the high-Tc superconductor Bi2Sr2CaCu2O8+δ

NASA Astrophysics Data System (ADS)

Doty, Constance; Cerkoney, Daniel; Gramajo, Ashley; Campbell, Tyler; Reid, Candy; Morales, Manuel; Delfanazari, Kaveh; Yamamoto, Takashi; Tsujimoto, Manabu; Kashiwagi, Takanari; Watanabe, Chiharu; Minami, Hidetoshi; Kadowaki, Kazuo; Klemm, Richard

We study the transverse magnetic (TM) electromagnetic cavity mode wave functions for an ideal equilateral triangular microstrip antenna exhibiting C3v point group symmetry, which restricts the number of TM(n,m) modes to | m - n | = 3 p , where the integer p > 0 for the modes odd and even about the three mirror planes, but p = 0 can also exist for the even modes. We calculate the wave functions and the power distribution forms from the uniform Josephson current source and from the excitation of one of these cavity modes, and fit data on an early equilateral triangular Bi2Sr2CaCu2O8+δ mesa, for which the C3v symmetry was apparently broken. Work supported in part by the UCF RAMP, JSPS Fellowship, CREST-JST, and WPI-MANA.

Electrostatic Charging of Spacecraft in Geosynchronous Orbit

DTIC Science & Technology

1992-12-17

degrees above and below the equatorial plane. All mirrors are fabricated from " Zerodur * which has a very low coefficient of expansion, and are coated with a...conducting black paint, and the mirror itself is constructed of Zerodur and silvered on the front surface. The mirror is electrically isolated from the...TM Sp 389 provides East-West scanning, and the radiometer mirror is used to scan in the North-South direction; the mirror is moved by two pixels pcr

An Assessment of the Crossed Porro Prism Resonator

DTIC Science & Technology

1980-08-01

to P n 7 + 4tan-{(4( 1 - 2/(n) 2) In the laser, the plane polarised beam from the polarising beam splitter ERL-OI(2-TM - 2 - will, on emerging from... Beam intensities in resonators 17. Ray path rotation in crossed porro resonator 18. Elliptically polarised light ray - I I•HI,-O ,-0162-IM I...military laser rangefinder and designator applications. This paper reviews the properties of these devices and examines the advantages over normal mirror

High performance thermoplastics - A review of neat resin and composite properties

NASA Technical Reports Server (NTRS)

Johnston, Norman J.; Hergenrother, Paul M.

1987-01-01

A review was made of the principal thermoplastics used to fabricate high performance composites. Neat resin tensile and fracture toughness properties, glass transition temperatures (Tg), crystalline melt temperatures (Tm) and approximate processing conditions are presented. Mechanical properties of carbon fiber composites made from many of these thermoplastics are given, including flexural, longitudinal tensile, transverse tensile and in-plane shear properties as well as short beam shear and compressive strengths and interlaminar fracture toughness.

Localized, Non-Harmonic Active Flap Motions for Low Frequency In-Plane Rotor Noise Reduction

DTIC Science & Technology

2012-05-01

rotating -frame cyclic variations, of two- per-rev or greater, to augment blade motions and blade airloads. Recent studies (Refs. 5, 6) have...Advancing tip Mach number MH Rotational (Hover) tip Mach number NM Noise metric, peak-to-peak value R Blade radius α...from a full-scale, 2,900 lb. gross weight, four-bladed S-434TM helicopter. The rotor head, blade cuffs , and swash-plate were production S

Plane-Wave DFT Methods for Chemistry

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bylaska, Eric J.

A detailed description of modern plane-wave DFT methods and software (contained in the NWChem package) are described that allow for both geometry optimization and ab initio molecular dynamics simulations. Significant emphasis is placed on aspects of these methods that are of interest to computational chemists and useful for simulating chemistry, including techniques for calculating charged systems, exact exchange (i.e. hybrid DFT methods), and highly efficient AIMD/MM methods. Sample applications on the structure of the goethite+water interface and the hydrolysis of nitroaromatic molecules are described.

Validation of zero-order feedback strategies for medium range air-to-air interception in a horizontal plane

NASA Technical Reports Server (NTRS)

Shinar, J.

1982-01-01

A zero order feedback solution of a variable speed interception game between two aircraft in the horizontal plane, obtained by using the method of forced singular perturbation (FSP), is compared with the exact open loop solution. The comparison indicates that for initial distances of separation larger than eight turning radii of the evader, the accuracy of the feedback approximation is better than one percent. The result validates the zero order FSP approximation for medium range air combat analysis.

Generation of an incident focused light pulse in FDTD.

PubMed

Capoğlu, Ilker R; Taflove, Allen; Backman, Vadim

2008-11-10

A straightforward procedure is described for accurately creating an incident focused light pulse in the 3-D finite-difference time-domain (FDTD) electromagnetic simulation of the image space of an aplanatic converging lens. In this procedure, the focused light pulse is approximated by a finite sum of plane waves, and each plane wave is introduced into the FDTD simulation grid using the total-field/scattered-field (TF/SF) approach. The accuracy of our results is demonstrated by comparison with exact theoretical formulas.

Generation of an incident focused light pulse in FDTD

PubMed Central

Çapoğlu, İlker R.; Taflove, Allen; Backman, Vadim

2009-01-01

A straightforward procedure is described for accurately creating an incident focused light pulse in the 3-D finite-difference time-domain (FDTD) electromagnetic simulation of the image space of an aplanatic converging lens. In this procedure, the focused light pulse is approximated by a finite sum of plane waves, and each plane wave is introduced into the FDTD simulation grid using the total-field/scattered-field (TF/SF) approach. The accuracy of our results is demonstrated by comparison with exact theoretical formulas. PMID:19582013

High resolution electron microscopy study of a high Cu variant of Weldalite (tm) 049 and a high strength Al-Cu-Ag-Mg-Zr alloy

NASA Technical Reports Server (NTRS)

Herring, R. A.; Gayle, Frank W.; Pickens, Joseph R.

1991-01-01

Weldalite (trademark) 049 is an Al-Cu-Li-Ag-Mg alloy that is strengthened in artificially aged tempers primarily by very thin plate-like precipitates lying on the set of (111) matrix planes. This precipitate might be expected to be the T(sub 1) phase, Al2CuLi, which has been observed in Al-Cu-Li alloys. However, in several ways this precipitate is similar to the omega phase which also appears as the set of (111) planes plates and is found in Al-Cu-Ag-Mg alloys. The study was undertaken to identify the set of (111) planes precipitate or precipitates in Weldalite (trademark) 049 in the T8 (stretched and artificially aged) temper, and to determine whether T(sub 1), omega, or some other phase is primarily responsible for the high strength (i.e., 700 MPa tensile strength) in this Al-Cu-Li-Ag-Mg alloy.

Speckle patterns produced by an optical vortex and its application to surface roughness measurements.

PubMed

Passos, M H M; Lemos, M R; Almeida, S R; Balthazar, W F; da Silva, L; Huguenin, J A O

2017-01-10

In this work, we report on the analysis of speckle patterns produced by illuminating different rough surfaces with an optical vortex, a first-order (l=1) Laguerre-Gaussian beam. The generated speckle patterns were observed in the normal direction exploring four different planes: the diffraction plane, image plane, focal plane, and exact Fourier transform plane. The digital speckle patterns were analyzed using the Hurst exponent of digital images, an interesting tool used to study surface roughness. We show a proof of principle that the Hurst exponent of a digital speckle pattern is more sensitive with respect to the surface roughness when the speckle pattern is produced by an optical vortex and observed at a focal plane. We also show that Hurst exponents are not so sensitive with respect to the topological charge l. These results open news possibilities of investigation into speckle metrology once we have several techniques that use speckle patterns for different applications.

Ion recombination and polarity correction factors for a plane-parallel ionization chamber in a proton scanning beam.

PubMed

Liszka, Małgorzata; Stolarczyk, Liliana; Kłodowska, Magdalena; Kozera, Anna; Krzempek, Dawid; Mojżeszek, Natalia; Pędracka, Anna; Waligórski, Michael Patrick Russell; Olko, Paweł

2018-01-01

To evaluate the effect on charge collection in the ionization chamber (IC) in proton pencil beam scanning (PBS), where the local dose rate may exceed the dose rates encountered in conventional MV therapy by up to three orders of magnitude. We measured values of the ion recombination (k s ) and polarity (k pol ) correction factors in water, for a plane-parallel Markus TM23343 IC, using the cyclotron-based Proteus-235 therapy system with an active proton PBS of energies 30-230 MeV. Values of k s were determined from extrapolation of the saturation curve and the Two-Voltage Method (TVM), for planar fields. We compared our experimental results with those obtained from theoretical calculations. The PBS dose rates were estimated by combining direct IC measurements with results of simulations performed using the FLUKA MC code. Values of k s were also determined by the TVM for uniformly irradiated volumes over different ranges and modulation depths of the proton PBS, with or without range shifter. By measuring charge collection efficiency versus applied IC voltage, we confirmed that, with respect to ion recombination, our proton PBS represents a continuous beam. For a given chamber parameter, e.g., nominal voltage, the value of k s depends on the energy and the dose rate of the proton PBS, reaching c. 0.5% for the TVM, at the dose rate of 13.4 Gy/s. For uniformly irradiated regular volumes, the k s value was significantly smaller, within 0.2% or 0.3% for irradiations with or without range shifter, respectively. Within measurement uncertainty, the average value of k pol , for the Markus TM23343 IC, was close to unity over the whole investigated range of clinical proton beam energies. While no polarity effect was observed for the Markus TM23343 IC in our pencil scanning proton beam system, the effect of volume recombination cannot be ignored. © 2017 American Association of Physicists in Medicine.

The ICET-A Recommendations for the Diagnosis and Management of Disturbances of Glucose Homeostasis in Thalassemia Major Patients

PubMed Central

De Sanctis, Vincenzo; Soliman, Ashraf T.; Elsedfy, Heba; Yaarubi, Saif AL; Skordis, Nicos; Khater, Doaa; El Kholy, Mohamed; Stoeva, Iva; Fiscina, Bernadette; Angastiniotis, Michael; Daar, Shahina; Kattamis, Christos

2016-01-01

Iron overload in patients with thalassemia major (TM) affects glucose regulation and is mediated by several mechanisms. The pathogenesis of glycaemic abnormalities in TM is complex and multifactorial. It has been predominantly attributed to a combination of reduced insulin secretory capacity and insulin resistance. The exact mechanisms responsible for progression from norm glycaemia to overt diabetes in these patients are still poorly understood but are attributed mainly to insulin deficiency resulting from the toxic effects of iron deposited in the pancreas and insulin resistance. A group of endocrinologists, haematologists and paediatricians, members of the International Network of Clinicians for Endocrinopathies in Thalassemia and Adolescence Medicine (ICET-A) convened to formulate recommendations for the diagnosis and management of abnormalities of glucose homeostasis in thalassemia major patients on the basis of available evidence from clinical and laboratory data and consensus practice. The results of their work and discussions are described in this article. PMID:27872738

Free energy and phase transition of the matrix model on a plane wave

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hadizadeh, Shirin; Ramadanovic, Bojan; Semenoff, Gordon W.

2005-03-15

It has recently been observed that the weakly coupled plane-wave matrix model has a density of states which grows exponentially at high energy. This implies that the model has a phase transition. The transition appears to be of first order. However, its exact nature is sensitive to interactions. In this paper, we analyze the effect of interactions by computing the relevant parts of the effective potential for the Polyakov loop operator in the finite temperature plane-wave matrix model to three-loop order. We show that the phase transition is indeed of first order. We also compute the correction to the Hagedornmore » temperature to order two loops.« less

An exact solution for a thick domain wall in general relativity

NASA Technical Reports Server (NTRS)

Goetz, Guenter; Noetzold, Dirk

1989-01-01

An exact solution of the Einstein equations for a static, planar domain wall with finite thickness is presented. At infinity, density and pressure vanish and the space-time tends to the Minkowski vacuum on one side of the wall and to the Taub vacuum on the other side. A surprising feature of this solution is that the density and pressure distribution are symmetric about the central plane of the wall whereas the space-time metric and therefore also the gravitational field experienced by a test particle is asymmetric.

Exact Rayleigh scattering calculations for use with the Nimbus-7 Coastal Zone Color Scanner

NASA Technical Reports Server (NTRS)

Gordon, Howard R.; Brown, James W.; Evans, Robert H.

1988-01-01

The radiance reflected from a plane-parallel atmosphere and flat sea surface in the absence of aerosols has been determined with an exact multiple scattering code to improve the analysis of Nimbus-7 CZCS imagery. It is shown that the single scattering approximation normally used to compute this radiance can result in errors of up to 5 percent for small and moderate solar zenith angles. A scheme to include the effect of variations in the surface pressure in the exact computation of the Rayleigh radiance is discussed. The results of an application of these computations to CZCS imagery suggest that accurate atmospheric corrections can be obtained for solar zenith angles at least as large as 65 deg.

Ferrofluid patterns in Hele-Shaw cells: Exact, stable, stationary shape solutions.

PubMed

Lira, Sérgio A; Miranda, José A

2016-01-01

We investigate a quasi-two-dimensional system composed of an initially circular ferrofluid droplet surrounded by a nonmagnetic fluid of higher density. These immiscible fluids flow in a rotating Hele-Shaw cell, under the influence of an in-plane radial magnetic field. We focus on the situation in which destabilizing bulk magnetic field effects are balanced by stabilizing centrifugal forces. In this framing, we consider the interplay of capillary and magnetic normal traction effects in determining the fluid-fluid interface morphology. By employing a vortex-sheet formalism, we have been able to find a family of exact stationary N-fold polygonal shape solutions for the interface. A weakly nonlinear theory is then used to verify that such exact interfacial solutions are in fact stable.

Users Guide for Smooth-Prop: A Program for Smoothing Propeller Tip Geometry

DTIC Science & Technology

2013-10-01

Research and Development Canada – Atlantic Technical Memorandum DRDC Atlantic TM 2013-179 October 2013 c© Her Majesty the Queen in Right of Canada...a window You can magnify any region of the Blade or Plane Intersection windows by clicking and dragging with the left mouse button. A red rectangle...display. Each slider is a long rectangle containing a smaller black box: see Fig. 9. The black box is a handle that can be dragged back and forth

Optical Behavior of III-TM-N Materials and Devices

DTIC Science & Technology

2008-09-26

0296 University of Florida GaN films were doped with Eu to a concentration of ~0.12 at. % during growth at 800 °C by molecular beam epitaxy , with...MAGNETIC SEMICONDUCTOR GROWTH AND CHARACTERIZATION Growth of the films presented occurred in a Varian Gen II by gas-source molecular beam epitaxy ...versus temperature for films of either undoped AlN, single phase AlMnN, or Mn4N. AlCrN films were grown by Molecular Beam Epitaxy (MBE) on c-plane

Electromagnetic scattering from two-dimensional thick material junctions

NASA Technical Reports Server (NTRS)

Ricoy, M. A.; Volakis, John L.

1990-01-01

The problem of the plane wave diffraction is examined by an arbitrary symmetric two dimensional junction, where Generalized Impedance Boundary Conditions (GIBCs) and Generalized Sheet Transition Conditions (GSTCs) are employed to simulate the slabs. GIBCs and GSTCs are constructed for multilayer planar slabs of arbitrary thickness and the resulting GIBC/GSTC reflection coefficients are compared with exact counterparts to evaluate the GIBCs/GSTCs. The plane wave diffraction by a multilayer material slab recessed in a perfectly conducting ground plane is formulated and solved via the Generalized Scattering Matrix Formulation (GDMF) in conjunction with the dual integral equation approach. Various scattering patterns are computed and validated with exact results where possible. The diffraction by a material discontinuity in a thick dielectric/ferrite slab is considered by modelling the constituent slabs with GSTCs. A non-unique solution in terms of unknown constants is obtained, and these constants are evaluated for the recessed slab geometry by comparison with the solution obtained therein. Several other simplified cases are also presented and discussed. An eigenfunction expansion method is introduced to determine the unknown solution constants in the general case. This procedure is applied to the non-unique solution in terms of unknown constants; and scattering patterns are presented for various slab junctions and compared with alternative results where possible.

Precision tip-tilt-piston actuator that provides exact constraint

DOEpatents

Hale, Layton C.

1999-01-01

A precision device which can precisely actuate three degrees of freedom of an optic mount, commonly referred to as tip, tilt, and piston. The device consists of three identical flexure mechanisms, an optic mount to be supported and positioned, a structure that supports the flexure mechanisms, and three commercially available linear actuators. The advantages of the precision device is in the arrangement of the constraints offered by the flexure mechanism and not in the particular design of the flexure mechanisms, as other types of mechanisms could be substituted. Each flexure mechanism constrains two degrees of freedom in the plane of the mechanisms and one direction is actuated. All other degrees of freedom are free to move within the range of flexure mechanisms. Typically, three flexure mechanisms are equally spaced in angle about to optic mount and arranged so that each actuated degree of freedom is perpendicular to the plane formed by the optic mount. This arrangement exactly constrains the optic mount and allows arbitrary actuated movement of the plane within the range of the flexure mechanisms. Each flexure mechanism provides a mechanical advantage, typically on the order of 5:1, between the commercially available actuator and the functional point on the optic mount. This improves resolution by the same ratio and stiffness by the square of the ratio.

Voltage tunable plasmon propagation in dual gated bilayer graphene

NASA Astrophysics Data System (ADS)

Farzaneh, Seyed M.; Rakheja, Shaloo

2017-10-01

In this paper, we theoretically investigate plasmon propagation characteristics in AB and AA stacked bilayer graphene (BLG) in the presence of energy asymmetry due to an electrostatic field oriented perpendicularly to the plane of the graphene sheet. We first derive the optical conductivity of BLG using the Kubo formalism incorporating energy asymmetry and finite electron scattering. All results are obtained for room temperature (300 K) operation. By solving Maxwell's equations in a dual gate device setup, we obtain the wavevector of propagating plasmon modes in the transverse electric (TE) and transverse magnetic (TM) directions at terahertz frequencies. The plasmon wavevector allows us to compare the compression factor, propagation length, and the mode confinement of TE and TM plasmon modes in bilayer and monolayer graphene sheets and also to study the impact of material parameters on plasmon characteristics. Our results show that the energy asymmetry can be harnessed to increase the propagation length of TM plasmons in BLG. AA stacked BLG shows a larger increase in the propagation length than AB stacked BLG; conversely, it is very insensitive to the Fermi level variations. Additionally, the dual gate structure allows independent modulation of the energy asymmetry and the Fermi level in BLG, which is advantageous for reconfiguring plasmon characteristics post device fabrication.

Chinchilla middle-ear admittance and sound power: High-frequency estimates and effects of inner-ear modifications

PubMed Central

Ravicz, Michael E.; Rosowski, John J.

2012-01-01

The middle-ear input admittance relates sound power into the middle ear (ME) and sound pressure at the tympanic membrane (TM). ME input admittance was measured in the chinchilla ear canal as part of a larger study of sound power transmission through the ME into the inner ear. The middle ear was open, and the inner ear was intact or modified with small sensors inserted into the vestibule near the cochlear base. A simple model of the chinchilla ear canal, based on ear canal sound pressure measurements at two points along the canal and an assumption of plane-wave propagation, enables reliable estimates of YTM, the ME input admittance at the TM, from the admittance measured relatively far from the TM. YTM appears valid at frequencies as high as 17 kHz, a much higher frequency than previously reported. The real part of YTM decreases with frequency above 2 kHz. Effects of the inner-ear sensors (necessary for inner ear power computation) were small and generally limited to frequencies below 3 kHz. Computed power reflectance was ∼0.1 below 3.5 kHz, lower than with an intact ME below 2.5 kHz, and nearly 1 above 16 kHz. PMID:23039439

Lasing in a nematic liquid crystal cell with an interdigitated electrode system

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shtykov, N M; Palto, S P; Umanskii, B A

2015-04-30

Waveguide lasing in a layer of a dye-doped nematic liquid crystal has been observed. The liquid-crystal layer was sandwiched between a quartz substrate and a glass cover plate on whose surface was deposited an interdigitated electrode system. This system had a period of 3.75 μm and played a dual role, namely, it created a spatial periodicity of the waveguide medium refractive index (thus creating distributed feedback) and served as a diffraction grating coupling out a part of waveguide radiation into the glass cover plate. The distributed feedback ensured lasing in the 18th diffraction order for the TE modes and inmore » the 19th order for the TM modes of the waveguide. The generated radiation was observed at the exit from the glass plate end face at the angles to the waveguide plane of 33.1 ± 1.5° for TM modes and 21.8 ± 1.8° for TE modes. The intensity and position of the TE emission line showed no regular dependence on the voltage on the electrodes. In the case of TM radiation, an increase in the voltage led to a short-wavelength shift of the laser line and to a decrease in its intensity. (lasers)« less

General Notions on Macroscopic Theory of Waves in Plasmas; NOTIONS GENERALES SUR LA THEORIE MACROSCOPIQUE DES ONDES DANS LES PLASMAS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Allis, W.P.; Delcroix, J.L.

1963-01-01

The propagation of monochromatic plane waves in an indefinite plasma is treated in the hydrodynamic theory of two fluids. Plasmas with isotropic pressure and waves obeying exact adiabaticity are considered. (D.C.W.)

Optimal multiple-pass aeroassisted plane change

NASA Technical Reports Server (NTRS)

Vinh, Nguyen X.; Ma, Der-Ming

1990-01-01

This paper presents the exact dimensionless equation of motion and the necessary conditions for the computation of the optimal trajectories of a hypervelocity vehicle flying through a non-rotating spherical planetary atmosphere. Numerical solution is then presented for the case when the vehicle makes several passages through the atmosphere near the perigee of its orbit. While the orbit is slowly contracting, aerodynamic maneuver is performed to obtain the maximum plane change. Several plots were presented to show the optimal variations of the lift coefficient and the bank angle and the various elements of the orbit.

Electronic and crystal structure changes induced by in-plane oxygen vacancies in multiferroic YMnO 3

DOE PAGES

Cheng, Shaobo; Meng, Qingping; Li, Mengli; ...

2016-02-08

Here, the widely spread oxygen vacancies (V O) in multiferroic materials can strongly affect their physical properties. However, their exact influence has rarely been identified in hexagonal manganites. Here, with the combined use of transmission electron microscopy (TEM) and first-principles calculations, we have systematically studied the electronic and crystal structure modifications induced by V O located at the same Mn atomic plane (in-plane V O). Our TEM experiments reveal that the easily formed in-plane V O not only influence the electronic structure of YMnO 3 but alter the in-plane Wyckoff positions of Mn ions, which may subsequently affect the intraplanemore » and interplane exchange interaction of Mn ions. The ferroelectricity is also impaired due to the introduction of V O. Further calculations confirm these electronic and structural changes and modifications. Our results indicate that the electronic and crystal structure of YMnO 3 can be manipulated by the creation of V O.« less

Type IIB Colliding Plane Waves

NASA Astrophysics Data System (ADS)

Gutperle, M.; Pioline, B.

2003-09-01

Four-dimensional colliding plane wave (CPW) solutions have played an important role in understanding the classical non-linearities of Einstein's equations. In this note, we investigate CPW solutions in 2n+2-dimensional Einstein gravity with a n+1-form flux. By using an isomorphism with the four-dimensional problem, we construct exact solutions analogous to the Szekeres vacuum solution in four dimensions. The higher-dimensional versions of the Khan-Penrose and Bell-Szekeres CPW solutions are studied perturbatively in the vicinity of the light-cone. We find that under small perturbations, a curvature singularity is generically produced, leading to both space-like and time-like singularities. For n = 4, our results pertain to the collision of two ten-dimensional type-IIB Blau-Figueroa o'Farrill-Hull-Papadopoulos plane waves.

Spectroscopy and lasing of Tm:SrMoO4 crystal near 1.5, 1.9, and 2.3-μm under 793-nm excitation

NASA Astrophysics Data System (ADS)

Šulc, Jan; Švejkar, Richard; Němec, Michal; Doroshenko, Maxim E.; Jelínková, Helena; Ivleva, Liudmila I.; Dunaeva, Elizaveta E.

2018-02-01

The spectroscopy properties and lasing of diode pumped Tm-doped strontium molybdate SrMoO4 single crystal were investigated at room temperature. The Tm:SrMoO4 crystal was grown by modified Stepanov method (2 wt.% of TmNbO4 in the melt). The tested Tm:SrMoO4 sample was cut from the grown crystal boule perpendicularly to growth direction 100. For spectroscopy and laser experiments 4.2mm thick plane-parallel face-polished plate (without AR coatings) was used. A fiber-coupled laser diode operating at wavelength 793nm was used for longitudinal Tm:SrMoO4 pumping which corresponds to 3H4 level excitation. Fluorescence spectra measurement showed strong emission in vicinity of 1.8 μm (3F4 -> 3H6 transition), and also significant emission close to wavelengths 1.45 μm (3H4 -> 3F4 transition) and 2.3 μm (3H4 -> 3H5 transition). The lasing was successfully reached for all these three transitions and output characteristics were measured. The pumping laser diode was operating in the pulsed regime with a low duty cycle. The 145mm long semi-hemispherical laser resonator consisted of flat pumping mirror (HT @ 0.79 μm) and curved (r = 150mm) output coupler. For each lasing transition the particular set of resonator mirrors was used to reach high reflexivity of pumping mirror and output coupler transmission 0.5% at laser operation wavelength. The obtained laser emission wavelengths were 1.95 μm, 1.45 & 1.49 μm, and 2.30 μm. In spite of low laser slope efficiency in respect to absorbed pumping power (0.45% for 3H4 -> 3F4 transition, 0.50% for 3F4 -> 3H6 transition and 0.83% for 3H4 -> 3H5 transition), results obtained are promising for further development of diode-pumped laser at 2.3 μm spectral region.

Comparison of various excitation and detection schemes for dye-doped polymeric whispering gallery mode micro-lasers.

PubMed

Siegle, Tobias; Kellerer, Jonas; Bonenberger, Marielle; Krämmer, Sarah; Klusmann, Carolin; Müller, Marius; Kalt, Heinz

2018-02-05

We compare different excitation and collection configurations based on free-space optics and evanescently coupled tapered fibers for both lasing and fluorescence emission from dye-doped doped polymeric whispering gallery mode (WGM) micro-disk lasers. The focus of the comparison is on the lasing threshold and efficiency of light collection. With the aid of optical fibers, we localize the pump energy to the cavity-mode volume and reduce the necessary pump energy to achieve lasing by two orders of magnitude. When using fibers for detection, the collection efficiency is enhanced by four orders of magnitude compared to a free-space read-out perpendicular to the resonator plane. By enhancing the collection efficiency we are able to record a pronounced modulation of the dye fluorescence under continuous wave (cw) pumping conditions evoked by coupling to the WGMs. Alternatively to fibers as a collection tool, we present a read-out technique based on the detection of in-plane radiated light. We show that this method is especially beneficial in an aqueous environment as well as for size-reduced micro-lasers where radiation is strongly pronounced. Furthermore, we show that this technique allows for the assignment of transverse electric (TE) and transverse magnetic (TM) polarization to the observed fundamental modes in a water environment by performing polarization-dependent photoluminescence (PL) spectroscopy. We emphasize the importance of the polarization determination for sensing applications and verify expected differences in the bulk refractive index sensitivity for TE and TM WGMs experimentally.

Comparison of two leading uniform theories of edge diffraction with the exact uniform asymptotic solution

NASA Technical Reports Server (NTRS)

Boersma, J.; Rahmat-Samii, Y.

1980-01-01

The diffraction of an arbitrary cylindrical wave by a half-plane has been treated by Rahmat-Samii and Mittra who used a spectral domain approach. In this paper, their exact solution for the total field is expressed in terms of a new integral representation. For large wave number k, two rigorous procedures are described for the exact uniform asymptotic expansion of the total field solution. The uniform expansions obtained are valid in the entire space, including transition regions around the shadow boundaries. The final results are compared with the formulations of two leading uniform theories of edge diffraction, namely, the uniform asymptotic theory and the uniform theory of diffraction. Some unique observations and conclusions are made in relating the two theories.

Features of sound propagation through and stability of a finite shear layer

NASA Technical Reports Server (NTRS)

Koutsoyannis, S. P.

1976-01-01

The plane wave propagation, the stability and the rectangular duct mode problems of a compressible inviscid linearly sheared parallel, but otherwise homogeneous flow, are shown to be governed by Whittaker's equation. The exact solutions for the perturbation quantities are essentially Whittaker M-functions. A number of known results are obtained as limiting cases of exact solutions. For the compressible finite thickness shear layer it is shown that no resonances and no critical angles exist for all Mach numbers, frequencies and shear layer velocity profile slopes except in the singular case of the vortex sheet.

Effect of Li level, artificial aging, and TiB2 reinforcement on the fracture toughness of Weldalite (tm) 049-type alloys

NASA Technical Reports Server (NTRS)

1991-01-01

Plane strain fracture toughness (K sub IC) was evaluated for Weldalite (tm) 049 with and without TiB2 reinforcement. For the nonreinforced variant, changes in toughness were measured for various aging conditions and lithium levels. Toughness testing was carried out on fatigue precracked compact tension (CT) specimens at 24 C, as per ASTM standard E-399. Toughness was measured as a function of aging time at 160 C for the two Weldalite 049(1.3) heats. The composition of these heats differed only in that 0.03 wt pct. Ti was added to one as an additional grain refiner. Both heats showed a decrease in toughness with increasing aging time, although toughness values for one were significantly higher than for the other. This greater toughness may be due to a subtle change in the grain size resulting for the presence of Ti or, alternatively, to differences in texture or substructure formed during extrusion.

Microchip laser operation of Tm,Ho:KLu(WO₄)₂ crystal.

PubMed

Loiko, Pavel; Serres, Josep Maria; Mateos, Xavier; Yumashev, Konstantin; Kuleshov, Nikolai; Petrov, Valentin; Griebner, Uwe; Aguiló, Magdalena; Díaz, Francesc

2014-11-17

A microchip laser is realized on the basis of a monoclinic Tm,Ho-codoped KLu(WO₄)₂crystal cut for light propagation along the Ng optical indicatrix axis. This crystal cut provides positive thermal lens with extremely weak astigmatism, S/M = 4%. High sensitivity factors, M = dD/dP(abs), of 24.9 and 24.1 m(-1)/W for the mg- and pg- tangential planes are calculated with respect to the absorbed pump power. Such thermo-optic behavior is responsible for mode stabilization in the plano-plano microchip laser cavity, as well as the demonstrated perfect circular beam profile (M(2) < 1.1). Maximum continuous-wave output power of 450 mW is obtained with a slope efficiency of 31%. A set of output couplers is employed to achieve lasing in the spectral range of 2060-2096 nm. The increase of output coupler transmission results in deterioration of the laser performance attributed to the increased up-conversion losses.

Effect of rare-earth ion size on local electron structure in RBa 2Cu 3O 7- δ (R = Tm, Dy, Gd, Eu, Nd and Y) superconductors: A positron study

NASA Astrophysics Data System (ADS)

Chen, Zhenping; Zhang, Jincang; Su, Yuling; Xue, Yuncai; Cao, Shixun

2006-02-01

The effects of rare-earth ionic size on the local electron structure, lattice parameters and superconductivity have been investigated by positron annihilation technique (PAT) and related experiments for RBa 2Cu 3O 7- δ (R = Tm, Dy, Gd, Eu, Nd and Y) superconductors. The local electron density ne is evaluated as a function of the rare-earth radius. The results show that both the bulk-lifetime τB and the defect lifetime τ2 increase with increasing rare-earth ionic radius, while the local electron density ne decrease with increasing rare-earth ionic radius. These results prove that the changes of ne, the degree of orthorhombic distortion and the coupling between the Cu-O chains and the CuO 2 planes all have an effect on the superconductivity of RBa 2Cu 3O 7- δ systems.

Colliding impulsive gravitational waves

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nutku, Y.; Halil, M.

1977-11-28

We formulate the problem of colliding plane gravitational waves with two polarizations as the harmonic mappings of Riemannian manifolds and construct an exact solution of the vacuum Einstein field equations describing the interaction of colliding impulsive gravitational waves which in the limit of collinear polarization reduces to the solution of Khan and Penrose.

Development of CO2 inversion system based on the adjoint of the global coupled transport model

NASA Astrophysics Data System (ADS)

Belikov, Dmitry; Maksyutov, Shamil; Chevallier, Frederic; Kaminski, Thomas; Ganshin, Alexander; Blessing, Simon

2014-05-01

We present the development of an inverse modeling system employing an adjoint of the global coupled transport model consisting of the National Institute for Environmental Studies (NIES) Eulerian transport model (TM) and the Lagrangian plume diffusion model (LPDM) FLEXPART. NIES TM is a three-dimensional atmospheric transport model, which solves the continuity equation for a number of atmospheric tracers on a grid spanning the entire globe. Spatial discretization is based on a reduced latitude-longitude grid and a hybrid sigma-isentropic coordinate in the vertical. NIES TM uses a horizontal resolution of 2.5°×2.5°. However, to resolve synoptic-scale tracer distributions and to have the ability to optimize fluxes at resolutions of 0.5° and higher we coupled NIES TM with the Lagrangian model FLEXPART. The Lagrangian component of the forward and adjoint models uses precalculated responses of the observed concentration to the surface fluxes and 3-D concentrations field simulated with the FLEXPART model. NIES TM and FLEXPART are driven by JRA-25/JCDAS reanalysis dataset. Construction of the adjoint of the Lagrangian part is less complicated, as LPDMs calculate the sensitivity of measurements to the surrounding emissions field by tracking a large number of "particles" backwards in time. Developing of the adjoint to Eulerian part was performed with automatic differentiation tool the Transformation of Algorithms in Fortran (TAF) software (http://www.FastOpt.com). This method leads to the discrete adjoint of NIES TM. The main advantage of the discrete adjoint is that the resulting gradients of the numerical cost function are exact, even for nonlinear algorithms. The overall advantages of our method are that: 1. No code modification of Lagrangian model is required, making it applicable to combination of global NIES TM and any Lagrangian model; 2. Once run, the Lagrangian output can be applied to any chemically neutral gas; 3. High-resolution results can be obtained over limited regions close to the monitoring sites (using the LPDM part), and at coarse resolution for the rest of the globe (using the Eulerian part), minimizing aggregation errors and computation cost. The adjoint of the coupled high-resolution Eulerian-Lagrangian model will be incorporated into the PYVAR CO2 variational inverse system (Chevallier et al., 2005). Chevallier, F., Fisher, M., Peylin, P., Serrar, S., Bousquet, P., Bréon, F.-M., Chédin, A., and Ciais, P.: Inferring CO2 sources and sinks from satellite observations: method and application to TOVS data, J. Geophys. Res., 110, D24309, doi:10.1029/2005JD006390, 2005.

Measurement of the magnetic anisotropy energy constants for magneto-optical recording media

NASA Technical Reports Server (NTRS)

Hajjar, R. A.; Wu, T. H.; Mansuripur, M.

1992-01-01

Measurement of the magneto-optical polar Kerr effect is performed on rare earth-transition metal (RE-TM) amorphous films using in-plane fields. From this measurement and the measurement of the saturation magnetization using a vibrating sample magnetometer (VSM), the magnetic anisotropy constants are determined. The temperature dependence is presented of the magnetic anisotropy in the range of -175 to 175 C. The results show a dip in the anisotropy near magnetic compensation. This anomaly is explained based on the finite exchange coupling between the rare earth and transition metal subnetworks.

High performance thermoplastics: A review of neat resin and composite properties

NASA Technical Reports Server (NTRS)

Johnston, Norman J.; Hergenrother, Paul M.

1987-01-01

A review was made of the principal thermoplastics used to fabricate high performance composites. Neat resin tensile and fracture toughness properties, glass transition temperatures (Tg), crystalline melt temperatures (Tm) and approximate processing conditions are presented. Mechanical properties of carbon fiber composites made from many of these thermoplastics are given, including flexural, longitudinal tensile, transverse tensile and in-plane shear properties as well as short beam shear and compressive strengths and interlaminar fracture toughness. Attractive features and problems involved in the use of thermo-plastics as matrices for high performance composites are discussed.

Long-term stable time integration scheme for dynamic analysis of planar geometrically exact Timoshenko beams

NASA Astrophysics Data System (ADS)

Nguyen, Tien Long; Sansour, Carlo; Hjiaj, Mohammed

2017-05-01

In this paper, an energy-momentum method for geometrically exact Timoshenko-type beam is proposed. The classical time integration schemes in dynamics are known to exhibit instability in the non-linear regime. The so-called Timoshenko-type beam with the use of rotational degree of freedom leads to simpler strain relations and simpler expressions of the inertial terms as compared to the well known Bernoulli-type model. The treatment of the Bernoulli-model has been recently addressed by the authors. In this present work, we extend our approach of using the strain rates to define the strain fields to in-plane geometrically exact Timoshenko-type beams. The large rotational degrees of freedom are exactly computed. The well-known enhanced strain method is used to avoid locking phenomena. Conservation of energy, momentum and angular momentum is proved formally and numerically. The excellent performance of the formulation will be demonstrated through a range of examples.

Analgesic efficacy of an oral transmucosal spray formulation of meloxicam alone or in combination with tramadol in cats with naturally occurring osteoarthritis.

PubMed

Monteiro, Beatriz P; Klinck, Mary P; Moreau, Maxim; Guillot, Martin; Steagall, Paulo Vm; Edge, Daniel K; Pelletier, Jean-Pierre; Martel-Pelletier, Johanne; Gauvin, Dominique; Del Castillo, Jérôme Re; Troncy, Eric

2016-11-01

To evaluate the analgesic efficacy of meloxicam oral transmucosal spray (OTMS) alone and with tramadol in cats with osteoarthritis (OA). Randomized, blinded study. Fifteen geriatric cats weighing 4.5 ± 1.0 kg. Healthy cats with OA were randomly administered a placebo (every 12 hours orally) and meloxicam OTMS (approximately 0.05 mg kg -1 every 24 hours) (group M, n = 7), or tramadol (3 mg kg -1 every 12 hours orally) and meloxicam OTMS (group TM, n = 8) for 25 days. Evaluations performed before treatment (D0) and at week 3 (W3) consisted of peak vertical force, motor activity and response to mechanical temporal summation of pain (RMTS). Data were analyzed with mixed models and Fisher's exact test. Mean ± standard deviation peak vertical force (percentage of body weight) increased significantly in both groups (p = 0.02), from 47.7 ± 6.5% to 60.5 ± 9.4% in group M, and from 51.8 ± 5.0% to 64.1 ± 6.5% in group TM, with no difference between groups. Motor activity increased in M (from 43 ± 12 to 56 ± 13; p = 0.02), but not in TM. The number of stimulations from RMTS increased in TM only. Cut-off values were reached in a larger number of cats (n = 5) in TM than M (n = 1) (p < 0.05). Gastrointestinal adverse effects were self-limiting in six cats, including five in TM. Meloxicam OTMS had similar effects on peak vertical force, motor activity and pain sensitization as previously reported for oral meloxicam in OA cats. The tramadol-meloxicam combination provided no evident benefit over meloxicam alone, except for central hypersensitivity (assessed with RMTS). Further assessment of the potential toxicity of the combination is required prior to clinical use. Gingival administration was well accepted overall. © 2016 Association of Veterinary Anaesthetists and the American College of Veterinary Anesthesia and Analgesia.

Bending of solitons in weak and slowly varying inhomogeneous plasma

NASA Astrophysics Data System (ADS)

Mukherjee, Abhik; Janaki, M. S.; Kundu, Anjan

2015-12-01

The bending of solitons in two dimensional plane is presented in the presence of weak and slowly varying inhomogeneous ion density for the propagation of ion acoustic soliton in unmagnetized cold plasma with isothermal electrons. Using reductive perturbation technique, a modified Kadomtsev-Petviashvili equation is obtained with a chosen unperturbed ion density profile. The exact solution of the equation shows that the phase of the solitary wave gets modified by a function related to the unperturbed inhomogeneous ion density causing the soliton to bend in the two dimensional plane, while the amplitude of the soliton remains constant.

Bending of solitons in weak and slowly varying inhomogeneous plasma

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mukherjee, Abhik, E-mail: abhik.mukherjee@saha.ac.in; Janaki, M. S., E-mail: ms.janaki@saha.ac.in; Kundu, Anjan, E-mail: anjan.kundu@saha.ac.in

2015-12-15

The bending of solitons in two dimensional plane is presented in the presence of weak and slowly varying inhomogeneous ion density for the propagation of ion acoustic soliton in unmagnetized cold plasma with isothermal electrons. Using reductive perturbation technique, a modified Kadomtsev-Petviashvili equation is obtained with a chosen unperturbed ion density profile. The exact solution of the equation shows that the phase of the solitary wave gets modified by a function related to the unperturbed inhomogeneous ion density causing the soliton to bend in the two dimensional plane, while the amplitude of the soliton remains constant.

On increasing stability in the two dimensional inverse source scattering problem with many frequencies

NASA Astrophysics Data System (ADS)

Entekhabi, Mozhgan Nora; Isakov, Victor

2018-05-01

In this paper, we will study the increasing stability in the inverse source problem for the Helmholtz equation in the plane when the source term is assumed to be compactly supported in a bounded domain Ω with a sufficiently smooth boundary. Using the Fourier transform in the frequency domain, bounds for the Hankel functions and for scattering solutions in the complex plane, improving bounds for the analytic continuation, and the exact observability for the wave equation led us to our goals which are a sharp uniqueness and increasing stability estimate when the wave number interval is growing.

Design of crossed planar phase grating for metrology

NASA Astrophysics Data System (ADS)

Tang, Yu; Chen, Xinrong; Li, Chaoming; Wang, Rui; Xu, Haiyan; Cheng, Yushui

2018-01-01

Crossed-grating is widely used as the standard element for metrology in two-dimensional precision positioning system. It has many advantages such as high resolution, compact structure, good environmental adaptability and less Abbe error. In this paper, the design of crossed planar reflecting phase grating used under the Littrow condition with circularly polarized light at 780nm wavelength has been carried out. The aim of the design is to find out the range of structure parameters of crossed-grating that has higher -1st order diffraction efficiency and good efficiency equilibrium for both of TE- and TM-polarized incident lights. By adoption of the Fourier modal method (FMM), the microstructure parameters of the 1200lines/mm crossed grating with the duty cycle range of 10% to 50% and the profile depth of 150nm to 350nm have been searched exactly. The calculation results show that: When the duty cycle range of the grating is 42% to 44% and profile depth is 210nm to 220nm, the -1st diffraction efficiencies of TE- and TM-polarized lights are both above 60% and the efficiency equilibrium is better than 80%.

Spin-orbit assisted transmission at 3d/5d metallic interfaces

NASA Astrophysics Data System (ADS)

Jaffres, Henri; Barbedienne, Quentin; Jouy, Augustin; Reyren, Nicolas; George, Jean-Marie; Laboratoire de Physique Et Des Plasmas, Ecole Polytechnique, Palaiseau, France Team; Unite Mixte de Physique Cnrs-Thales, Palaiseau, France Team

We will describe the anatomy of spin-transport and spin-orbit torques (SOT) at spin-orbit active interfaces involving 5d transition metals (TM) as heavy metals spin-Hall effect (SHE) materials and 3d TM in [Co,Ni]/Pt, NiFe. NiFe/Au:W and Co/Pt/Au;W systems. In the case of Pt, recent studies have put forward the major role played by the spin-memory loss (SML), the electronic transparency at 3d/5d interfaces and the inhomogeneity of the conductivity in the CIP-geometry. Ingredients to consider for spin-transport and spin-Hall Magnetoresistance (SMR) are the conductivity, the spin-current profiles across the multilayers and the spin-transmission. We will present SMR measurements observed on these systems possibly involving interfacial Anisotropy of Magnetoresistance (AIMR) contributions. We analyze in large details our SMR signals in the series of samples owing: i) the exact conductivity profile across the multilayers via the Camley-Barnas approach and the spin current profile generated by SHE. We will discuss the role of the generalized spin-mixing conductance on the spin-transport properties and spin-orbit torques.

ThMn12-type phases for magnets with low rare-earth content: Crystal-field analysis of the full magnetization process.

PubMed

Tereshina, I S; Kostyuchenko, N V; Tereshina-Chitrova, E A; Skourski, Y; Doerr, M; Pelevin, I A; Zvezdin, A K; Paukov, M; Havela, L; Drulis, H

2018-02-26

Rare-earth (R)-iron alloys are a backbone of permanent magnets. Recent increase in price of rare earths has pushed the industry to seek ways to reduce the R-content in the hard magnetic materials. For this reason strong magnets with the ThMn 12  type of structure came into focus. Functional properties of R(Fe,T) 12 (T-element stabilizes the structure) compounds or their interstitially modified derivatives, R(Fe,T) 12 -X (X is an atom of hydrogen or nitrogen) are determined by the crystal-electric-field (CEF) and exchange interaction (EI) parameters. We have calculated the parameters using high-field magnetization data. We choose the ferrimagnetic Tm-containing compounds, which are most sensitive to magnetic field and demonstrate that TmFe 11 Ti-H reaches the ferromagnetic state in the magnetic field of 52 T. Knowledge of exact CEF and EI parameters and their variation in the compounds modified by the interstitial atoms is a cornerstone of the quest for hard magnetic materials with low rare-earth content.

Silencing of Stress-Regulated miRNAs in Plants by Short Tandem Target Mimic (STTM) Approach.

PubMed

Teotia, Sachin; Tang, Guiliang

2017-01-01

In plants, microRNAs (miRNAs) regulate more than hundred target genes comprising largely transcription factors that control growth and development as well as stress responses. However, the exact functions of miRNA families could not be deciphered because each miRNA family has multiple loci in the genome, thus are functionally redundant. Therefore, an ideal approach to study the function of a miRNA family is to silence the expression of all members simultaneously, which is a daunting task. However, this can be partly overcome by Target Mimic (TM) approach that can knockdown an entire miRNA family. STTM is a modification of TM approach and complements it. STTMs have been successfully used in monocots and dicots to block miRNA functions. miR159 has been shown to be differentially regulated by various abiotic stresses including ABA in various plant species. Here, we describe in detail the protocol for designing STTM construct to block miR159 functions in Arabidopsis, with the potential to apply this technique on a number of other stress-regulated miRNAs in plants.

Photon escape probabilities in a semi-infinite plane-parallel medium. [from electron plasma surrounding galactic X-ray sources

NASA Technical Reports Server (NTRS)

Williams, A. C.; Elsner, R. F.; Weisskopf, M. C.; Darbro, W.

1984-01-01

It is shown in this work how to obtain the probabilities of photons escaping from a cold electron plasma environment after having undergone an arbitrary number of scatterings. This is done by retaining the exact differential cross section for Thomson scattering as opposed to using its polarization and angle averaged form. The results are given in the form of recursion relations. The geometry used is the semi-infinite plane-parallel geometry witlh a photon source located on a plane at an arbitrary optical depth below the surface. Analytical expressions are given for the probabilities which are accurate over a wide range of initial optical depth. These results can be used to model compact X-ray galactic sources which are surrounded by an electron-rich plasma.

Cumulant generating function formula of heat transfer in ballistic systems with lead-lead coupling

NASA Astrophysics Data System (ADS)

Li, Huanan; Agarwalla, Bijay Kumar; Wang, Jian-Sheng

2012-10-01

Based on a two-time observation protocol, we consider heat transfer in a given time interval tM in a lead-junction-lead system taking coupling between the leads into account. In view of the two-time observation, consistency conditions are carefully verified in our specific family of quantum histories. Furthermore, its implication is briefly explored. Then using the nonequilibrium Green's function method, we obtain an exact formula for the cumulant generating function for heat transfer between the two leads, valid in both transient and steady-state regimes. Also, a compact formula for the cumulant generating function in the long-time limit is derived, for which the Gallavotti-Cohen fluctuation symmetry is explicitly verified. In addition, we briefly discuss Di Ventra's repartitioning trick regarding whether the repartitioning procedure of the total Hamiltonian affects the nonequilibrium steady-state current fluctuation. All kinds of properties of nonequilibrium current fluctuations, such as the fluctuation theorem in different time regimes, could be readily given according to these exact formulas.

Unifying Exchange Sensitivity in Transition-Metal Spin-State Ordering and Catalysis through Bond Valence Metrics.

PubMed

Gani, Terry Z H; Kulik, Heather J

2017-11-14

Accurate predictions of spin-state ordering, reaction energetics, and barrier heights are critical for the computational discovery of open-shell transition-metal (TM) catalysts. Semilocal approximations in density functional theory, such as the generalized gradient approximation (GGA), suffer from delocalization error that causes them to overstabilize strongly bonded states. Descriptions of energetics and bonding are often improved by introducing a fraction of exact exchange (e.g., erroneous low-spin GGA ground states are instead correctly predicted as high-spin with a hybrid functional). The degree of spin-splitting sensitivity to exchange can be understood based on the chemical composition of the complex, but the effect of exchange on reaction energetics within a single spin state is less well-established. Across a number of model iron complexes, we observe strong exchange sensitivities of reaction barriers and energies that are of the same magnitude as those for spin splitting energies. We rationalize trends in both reaction and spin energetics by introducing a measure of delocalization, the bond valence of the metal-ligand bonds in each complex. The bond valence thus represents a simple-to-compute property that unifies understanding of exchange sensitivity for catalytic properties and spin-state ordering in TM complexes. Close agreement of the resulting per-metal-organic-bond sensitivity estimates, together with failure of alternative descriptors demonstrates the utility of the bond valence as a robust descriptor of how differences in metal-ligand delocalization produce differing relative energetics with exchange tuning. Our unified description explains the overall effect of exact exchange tuning on the paradigmatic two-state FeO + /CH 4 reaction that combines challenges of spin-state and reactivity predictions. This new descriptor-sensitivity relationship provides a path to quantifying how predictions in transition-metal complex screening are sensitive to the method used.

A spectral dynamic stiffness method for free vibration analysis of plane elastodynamic problems

NASA Astrophysics Data System (ADS)

Liu, X.; Banerjee, J. R.

2017-03-01

A highly efficient and accurate analytical spectral dynamic stiffness (SDS) method for modal analysis of plane elastodynamic problems based on both plane stress and plane strain assumptions is presented in this paper. First, the general solution satisfying the governing differential equation exactly is derived by applying two types of one-dimensional modified Fourier series. Then the SDS matrix for an element is formulated symbolically using the general solution. The SDS matrices are assembled directly in a similar way to that of the finite element method, demonstrating the method's capability to model complex structures. Any arbitrary boundary conditions are represented accurately in the form of the modified Fourier series. The Wittrick-Williams algorithm is then used as the solution technique where the mode count problem (J0) of a fully-clamped element is resolved. The proposed method gives highly accurate solutions with remarkable computational efficiency, covering low, medium and high frequency ranges. The method is applied to both plane stress and plane strain problems with simple as well as complex geometries. All results from the theory in this paper are accurate up to the last figures quoted to serve as benchmarks.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dubrovsky, V. G.; Topovsky, A. V.

New exact solutions, nonstationary and stationary, of Veselov-Novikov (VN) equation in the forms of simple nonlinear and linear superpositions of arbitrary number N of exact special solutions u{sup (n)}, n= 1, Horizontal-Ellipsis , N are constructed via Zakharov and Manakov {partial_derivative}-dressing method. Simple nonlinear superpositions are represented up to a constant by the sums of solutions u{sup (n)} and calculated by {partial_derivative}-dressing on nonzero energy level of the first auxiliary linear problem, i.e., 2D stationary Schroedinger equation. It is remarkable that in the zero energy limit simple nonlinear superpositions convert to linear ones in the form of the sums ofmore » special solutions u{sup (n)}. It is shown that the sums u=u{sup (k{sub 1})}+...+u{sup (k{sub m})}, 1 Less-Than-Or-Slanted-Equal-To k{sub 1} < k{sub 2} < Horizontal-Ellipsis < k{sub m} Less-Than-Or-Slanted-Equal-To N of arbitrary subsets of these solutions are also exact solutions of VN equation. The presented exact solutions include as superpositions of special line solitons and also superpositions of plane wave type singular periodic solutions. By construction these exact solutions represent also new exact transparent potentials of 2D stationary Schroedinger equation and can serve as model potentials for electrons in planar structures of modern electronics.« less

Self-accommodation of B19' martensite in Ti-Ni shape memory alloys. Part III. Analysis of habit plane variant clusters by the geometrically nonlinear theory

NASA Astrophysics Data System (ADS)

Inamura, T.; Nishiura, T.; Kawano, H.; Hosoda, H.; Nishida, M.

2012-06-01

Competition between the invariant plane (IP) condition at the habit plane, the twin orientation relation (OR) and the kinematic compatibility (KC) at the junction plane (JP) of self-accommodated B19‧ martensite in Ti-Ni was investigated via the geometrically nonlinear theory to understand the habit plane variant (HPV) clusters presented in Parts I and II of this work. As the IP condition cannot be satisfied simultaneously with KC, an additional rotation Q is necessary to form compatible JPs for all HPV pairs. The rotation J necessary to form the exact twin OR between the major correspondence variants (CVs) in each HPV was also examined. The observed HPV cluster was not the cluster with the smallest Q but the one satisfying Q = J with a { ? 1}B19‧ type I twin at JP. Both Q and J are crucial to understanding the various HPV clusters in realistic transformations. Finally, a scheme for the ideal HPV cluster composed of six HPVs is also proposed.

Correction of radiographic measurements of acetabular cup wear for variations in pelvis orientation.

PubMed

Derbyshire, Brian

2018-03-01

Radiographic measurement of two-dimensional acetabular cup wear is usually carried out on a series of follow-up radiographs of the patient's pelvis. Since the orientation of the pelvis might not be consistent at every X-ray examination, the resulting change in view of the wear plane introduces error into the linear wear measurement. This effect is amplified on some designs of cup in which the centre of the socket is several millimetres below the centre of the cup or circular wire marker. This study describes the formulation of a mathematical method to correct radiographic wear measurements for changes in pelvis orientation. A mathematical simulation of changes in cup orientation and wear vectors caused by pelvic tilt was used to confirm that the formulae corrected the wear exactly if the radiographic plane of the reference radiograph was parallel to the true plane of wear. An error analysis showed that even when the true wear plane was not parallel to the reference radiographic plane, the formulae could still provide a useful correction. A published correction formula was found to be ineffective.

Correction of radiographic measurements of acetabular cup wear for variations in pelvis orientation

PubMed Central

Derbyshire, Brian

2018-01-01

Radiographic measurement of two-dimensional acetabular cup wear is usually carried out on a series of follow-up radiographs of the patient’s pelvis. Since the orientation of the pelvis might not be consistent at every X-ray examination, the resulting change in view of the wear plane introduces error into the linear wear measurement. This effect is amplified on some designs of cup in which the centre of the socket is several millimetres below the centre of the cup or circular wire marker. This study describes the formulation of a mathematical method to correct radiographic wear measurements for changes in pelvis orientation. A mathematical simulation of changes in cup orientation and wear vectors caused by pelvic tilt was used to confirm that the formulae corrected the wear exactly if the radiographic plane of the reference radiograph was parallel to the true plane of wear. An error analysis showed that even when the true wear plane was not parallel to the reference radiographic plane, the formulae could still provide a useful correction. A published correction formula was found to be ineffective. PMID:29473454

A small-plane heat source method for measuring the thermal conductivities of anisotropic materials

NASA Astrophysics Data System (ADS)

Cheng, Liang; Yue, Kai; Wang, Jun; Zhang, Xinxin

2017-07-01

A new small-plane heat source method was proposed in this study to simultaneously measure the in-plane and cross-plane thermal conductivities of anisotropic insulating materials. In this method the size of the heat source element is smaller than the sample size and the boundary condition is thermal insulation due to no heat flux at the edge of the sample during the experiment. A three-dimensional model in a rectangular coordinate system was established to exactly describe the heat transfer process of the measurement system. Using the Laplace transform, variable separation, and Laplace inverse transform methods, the analytical solution of the temperature rise of the sample was derived. The temperature rises calculated by the analytical solution agree well with the results of numerical calculation. The result of the sensitivity analysis shows that the sensitivity coefficients of the estimated thermal conductivities are high and uncorrelated to each other. At room temperature and in a high-temperature environment, experimental measurements of anisotropic silica aerogel were carried out using the traditional one-dimensional plane heat source method and the proposed method, respectively. The results demonstrate that the measurement method developed in this study is effective and feasible for simultaneously obtaining the in-plane and cross-plane thermal conductivities of the anisotropic materials.

Features of sound propagation through and stability of a finite shear layer

NASA Technical Reports Server (NTRS)

Koutsoyannis, S. P.

1977-01-01

The plane wave propagation, the stability, and the rectangular duct mode problems of a compressible, inviscid, linearly sheared, parallel, homogeneous flow are shown to be governed by Whittaker's equation. The exact solutions for the perturbation quantities are essentially the Whittaker M-functions where the nondimensional quantities have precise physical meanings. A number of known results are obtained as limiting cases of the exact solutions. For the compressible finite thickness shear layer it is shown that no resonances and no critical angles exist for all Mach numbers, frequencies, and shear layer velocity profile slopes except in the singular case of the vortex sheet.

Improved treatment of exact exchange in Quantum ESPRESSO

DOE PAGES

Barnes, Taylor A.; Kurth, Thorsten; Carrier, Pierre; ...

2017-01-18

Here, we present an algorithm and implementation for the parallel computation of exact exchange in Quantum ESPRESSO (QE) that exhibits greatly improved strong scaling. QE is an open-source software package for electronic structure calculations using plane wave density functional theory, and supports the use of local, semi-local, and hybrid DFT functionals. Wider application of hybrid functionals is desirable for the improved simulation of electronic band energy alignments and thermodynamic properties, but the computational complexity of evaluating the exact exchange potential limits the practical application of hybrid functionals to large systems and requires efficient implementations. We demonstrate that existing implementations ofmore » hybrid DFT that utilize a single data structure for both the local and exact exchange regions of the code are significantly limited in the degree of parallelization achievable. We present a band-pair parallelization approach, in which the calculation of exact exchange is parallelized and evaluated independently from the parallelization of the remainder of the calculation, with the wavefunction data being efficiently transformed on-the-fly into a form that is optimal for each part of the calculation. For a 64 water molecule supercell, our new algorithm reduces the overall time to solution by nearly an order of magnitude.« less

Optimum Number of Anchored Clathrate Water and Its Instantaneous Fluctuations Dictate Ice Plane Recognition Specificities of Insect Antifreeze Protein.

PubMed

Chakraborty, Sandipan; Jana, Biman

2018-03-29

Ice recognition by antifreeze proteins (AFPs) is a subject of topical interest. Among several classes of AFPs, insect AFPs are hyperactive presumably due to their ability to adsorb on basal plane. However, the origin of the basal plane binding specificity is not clearly known. Present work aims to provide atomistic insight into the origin of basal plane recognition by an insect antifreeze protein. Free energy calculations reveal that the order of binding affinity of the AFP toward different ice planes is basal plane > prism plane > pyramidal plane. Critical insight reveals that the observed plane specificity is strongly correlated with the number and their instantaneous fluctuations of clathrate water forming hydrogen bonds with both ice binding surface (IBS) of AFP and ice surface, thus anchoring AFP to the ice surface. On basal plane, anchored clathrate water array is highly stable due to exact match in the periodicity of oxygen atom repeat distances of the ice surface and the threonine repeat distances at the IBS. The stability of anchored clathrate water array progressively decreases upon prism and pyramidal plane adsorption due to mismatch between the threonine ladder and oxygen atom repeat distance. Further analysis reveals that hydration around the methyl side-chains of threonine residues becomes highly significant at low temperature which stabilizes the anchored clathrate water array and dual hydrogen-bonding is a consequence of this stability. Structural insight gained from this study paves the way for rational designing of highly potent antifreeze-mimetic with potential industrial applications.

Presence of negative charge on the basal planes of New York talc.

PubMed

Burdukova, E; Becker, M; Bradshaw, D J; Laskowski, J S

2007-11-01

Potentiometric titration measurements as well as rheological measurements of talc aqueous suspensions indicate that the behavior of the New York talc particles is consistent with the presence of a negative charge on their basal planes. The possibility of the presence of a negative electrical charge on the basal planes of talc particles is analyzed in this paper. Samples of New York talc were studied using electron microprobe analysis and dehydration techniques and the exact chemical formula of New York talc was determined. It was found that there exists a deficiency of protons in the tetrahedral layers of talc, resulting from substitution of Si(4+) ions with Al(3+) and Ti(3+) ions. The comparison of the level of substitution of Si(4+) ions with ions of a lower valency was found to be of a similar order of magnitude as that found in other talc deposits. This strongly points to the presence of a negative charge on the talc basal planes.

On the Spectrum of the Plenoptic Function.

PubMed

Gilliam, Christopher; Dragotti, Pier-Luigi; Brookes, Mike

2014-02-01

The plenoptic function is a powerful tool to analyze the properties of multi-view image data sets. In particular, the understanding of the spectral properties of the plenoptic function is essential in many computer vision applications, including image-based rendering. In this paper, we derive for the first time an exact closed-form expression of the plenoptic spectrum of a slanted plane with finite width and use this expression as the elementary building block to derive the plenoptic spectrum of more sophisticated scenes. This is achieved by approximating the geometry of the scene with a set of slanted planes and evaluating the closed-form expression for each plane in the set. We then use this closed-form expression to revisit uniform plenoptic sampling. In this context, we derive a new Nyquist rate for the plenoptic sampling of a slanted plane and a new reconstruction filter. Through numerical simulations, on both real and synthetic scenes, we show that the new filter outperforms alternative existing filters.

Processed Thematic Mapper Satellite Imagery for Selected Areas within the U.S.-Mexico Borderlands

USGS Publications Warehouse

Dohrenwend, John C.; Gray, Floyd; Miller, Robert J.

2000-01-01

The study is summarized in the Adobe Acrobat Portable Document Format (PDF) file OF00-309.PDF. This publication also contain satellite full-scene images of selected areas along the U.S.-Mexico border. These images are presented as high-resolution images in jpeg format (IMAGES). The folder LOCATIONS in contains TIFF images showing exact positions of easily-identified reference locations for each of the Landsat TM scenes located at least partly within the U.S. A reference location table (BDRLOCS.DOC in MS Word format) lists the latitude and longitude of each reference location with a nominal precision of 0.001 minute of arc

Elasticity Theory Solution of the Problem on Plane Bending of a Narrow Layered Cantilever Beam by Loads at Its Free End

NASA Astrophysics Data System (ADS)

Goryk, A. V.; Koval'chuk, S. B.

2018-05-01

An exact elasticity theory solution for the problem on plane bending of a narrow layered composite cantilever beam by tangential and normal loads distributed on its free end is presented. Components of the stress-strain state are found for the whole layers package by directly integrating differential equations of the plane elasticity theory problem by using an analytic representation of piecewise constant functions of the mechanical characteristics of layer materials. The continuous solution obtained is realized for a four-layer beam with account of kinematic boundary conditions simulating the rigid fixation of its one end. The solution obtained allows one to predict the strength and stiffness of composite cantilever beams and to construct applied analytical solutions for various problems on the elastic bending of layered beams.

Exact simulation of polarized light reflectance by particle deposits

NASA Astrophysics Data System (ADS)

Ramezan Pour, B.; Mackowski, D. W.

2015-12-01

The use of polarimetric light reflection measurements as a means of identifying the physical and chemical characteristics of particulate materials obviously relies on an accurate model of predicting the effects of particle size, shape, concentration, and refractive index on polarized reflection. The research examines two methods for prediction of reflection from plane parallel layers of wavelength—sized particles. The first method is based on an exact superposition solution to Maxwell's time harmonic wave equations for a deposit of spherical particles that are exposed to a plane incident wave. We use a FORTRAN-90 implementation of this solution (the Multiple Sphere T Matrix (MSTM) code), coupled with parallel computational platforms, to directly simulate the reflection from particle layers. The second method examined is based upon the vector radiative transport equation (RTE). Mie theory is used in our RTE model to predict the extinction coefficient, albedo, and scattering phase function of the particles, and the solution of the RTE is obtained from adding—doubling method applied to a plane—parallel configuration. Our results show that the MSTM and RTE predictions of the Mueller matrix elements converge when particle volume fraction in the particle layer decreases below around five percent. At higher volume fractions the RTE can yield results that, depending on the particle size and refractive index, significantly depart from the exact predictions. The particle regimes which lead to dependent scattering effects, and the application of methods to correct the vector RTE for particle interaction, will be discussed.

The Fundamental Solutions for the Stress Intensity Factors of Modes I, II And III. The Axially Symmetric Problem

NASA Astrophysics Data System (ADS)

Rogowski, B.

2015-05-01

The subject of the paper are Green's functions for the stress intensity factors of modes I, II and III. Green's functions are defined as a solution to the problem of an elastic, transversely isotropic solid with a penny-shaped or an external crack under general axisymmetric loadings acting along a circumference on the plane parallel to the crack plane. Exact solutions are presented in a closed form for the stress intensity factors under each type of axisymmetric ring forces as fundamental solutions. Numerical examples are employed and conclusions which can be utilized in engineering practice are formulated.

Producibility of Vertically Integrated Photodiode (VIP)tm scanning focal plane arrays

NASA Astrophysics Data System (ADS)

Turner, Arthur M.; Teherani, Towfik; Ehmke, John C.; Pettitt, Cindy; Conlon, Peggy; Beck, Jeffrey D.; McCormack, Kent; Colombo, Luigi; Lahutsky, Tom; Murphy, Terry; Williams, Robert L.

1994-07-01

Vertically integrated photodiode, VIPTM, technology is now being used to produce second generation infrared focal plane arrays with high yields and performance. The VIPTM process employs planar, ion implanted, n on p diodes in HgCdTe which is epoxy hybridized directly to the read out integrated circuits on 100 mm Si wafers. The process parameters that are critical for high performance and yield include: HgCdTe dislocation density and thickness, backside passivation, frontside passivation, and junction formation. Producibility of infrared focal plane arrays (IRFPAs) is also significantly enhanced by read out integrated circuits (ROICs) which have the ability to deselect defective pixels. Cold probe screening before lab dewar assembly reduces costs and improves cycle times. The 240 X 1 and 240 X 2 scanning array formats are used to demonstrate the effect of process optimization, deselect, and cold probe screening on yield and cycle time. The versatility of the VIPTM technology and its extension to large area arrays is demonstrated using 240/288 X 4 and 480 X 5 TDI formats. Finally, the high performance of VIPTM IRFPAs is demonstrated by comparing data from a 480 X 5 to the SADA-II specification.

Mode and polarization state selected guided wave spectroscopy of orientational anisotrophy in model membrane cellulosic polymer films: relevance to lab-on-a-chip

NASA Astrophysics Data System (ADS)

Andrews, Mark P.; Kanigan, Tanya

2007-06-01

Orientation anisotropies in structural properties relevant to the use of cellulosic polymers as membranes for lab-on-chips were investigated for cellulose acetate (CA) and regenerated cellulose (RC) films deposited as slab waveguides. Anisotropy was probed with mode and polarization state selected guided wave Raman spectroscopy. CA exhibits partial chain orientation in the plane of the film, and this orientation is independent of sample substrate and film preparation conditions. RC films also show in-plane anisotropy, where the hexose sugar rings lie roughly in the plane of the film. Explanations are given of the role of artifacts in interpreting waveguide Raman spectra, including anomalous contributions to Raman spectra that arise from deviations from right angle scattering geometry, mode-dependent contributions to longitudinal electric field components and TE<-->TM mode conversion. We explore diffusion profiles of small molecules in cellulosic films by adaptations of an inverse-Wentzel-Kramers-Brillouin (iWKB) recursive, noninteger virtual mode index algorithm. Perturbations in the refractive index distribution, n(z), are recovered from the measured relative propagation constants, neffective,m, of the planar waveguide. The refractive index distribution then yields the diffusion profile.

Acoustic Models of Optical Mirrors

ERIC Educational Resources Information Center

Mayer, V. V.; Varaksina, E. I.

2014-01-01

Students form a more exact idea of the action of optical mirrors if they can observe the wave field being formed during reflection. For this purpose it is possible to organize model experiments with flexural waves propagating in thin elastic plates. The direct and round edges of the plates are used as models of plane, convex and concave mirrors.…

Polarized edge emission from GaN-based light-emitting diodes sandwiched by dielectric/metal hybrid reflectors

NASA Astrophysics Data System (ADS)

Yan, L. J.; Sheu, J. K.; Huang, F. W.; Lee, M. L.

2010-12-01

Edge-emitting c-plane GaN/sapphire-based light-emitting diodes (LEDs) sandwiched by two dielectric/metal hybrid reflectors on both sapphire and GaN surfaces were studied to determine their light emission polarization. The hybrid reflectors comprised dielectric multiple thin films and a metal layer. The metal layers of Au or Ag used in this study were designed to enhance the polarization ratio from S-polarization (transverse electric wave, TE) to P-polarization (transverse magnetic wave, TM). The two sets of optimized dielectric multi thin films served as matching layers for wide-angle incident light on both sapphire and GaN surfaces. To determine which reflector scheme would achieve a higher polarization ratio, simulations of the reflectance at the hybrid reflectors on sapphire (or GaN) interface were performed before the fabrication of experimental LEDs. Compared with conventional c-plane InGaN/GaN/sapphire LEDs without dielectric/metal hybrid reflectors, the experimental LEDs exhibited higher polarization ratio (ITE-max/ITM-max) with r=2.174 (˜3.37 dB) at a wavelength of 460 nm. In contrast, the original polarized light (without dielectric/metal hybrid reflectors) was partially contributed (r=1.398) by C-HH or C-LH (C band to the heavy-hole sub-band or C band to the crystal-field split-off sub-band) transitions along the a-plane or m-plane direction.

Metamaterial Designs for Photovoltaic and IR Focal-Plane-Imaging Array Applications

DTIC Science & Technology

2013-03-01

incident angles above 17 degrees. There also seems to be no Brewster angle (i.e. the angle at which reflection = 0) for the reflection from the MTM...half- space, while glass has as Brewster angle at 56 degrees incident for TM polarized light. 0 5 10 15 20 25 30 0 0.1 0.2 0.3 0.4 0.5 0.6 0.7 0.8 0.9...and incident spot beams from an objective lens . The spot beams hitting the detectors are absorbed, but the power of the spot beams falling in between

Volumetric evaluation of the rotator cuff musculature in massive rotator cuff tears with pseudoparalysis.

PubMed

Rhee, Yong Girl; Cho, Nam Su; Song, Jong Hoon; Park, Jung Gwan; Kim, Tae Yong

2017-09-01

If the balance of the rotator cuff force couple is disrupted, pseudoparalysis may occur, but the exact mechanism remains unknown. This study investigated the effect of rotator cuff force couple disruption on active range of motion in massive rotator cuff tear (mRCT) by rotator cuff muscle volume analysis. The study included 53 patients with irreparable mRCT: 22 in the nonpseudoparalysis group and 31 in the pseudoparalysis group. The volumes of the subscapularis (SBS), infraspinatus (ISP), and teres minor (TM) muscles were measured using magnetic resonance imaging (MRI), and the ratios of each muscle volume to the anatomic external rotator (aER) volume were calculated. A control group of 25 individuals with normal rotator cuffs was included. Anterior-to-posterior cuff muscle volume ratio (SBS/ISP + TM) was imbalanced in both mRCT groups (1.383 nonpseudoparalysis and 1.302 pseudoparalysis). Between the 2 groups, the ISP/aER ratio (0.277 vs. 0.249) and the inferior SBS/aER ratio (0.426 vs. 0.390) were significantly decreased in the pseudoparalysis group (P= .022 and P= .040, respectively). However, neither the TM/aER ratio (0.357 vs. 0.376) nor the superior SBS/aER ratio (0.452 vs. 0.424) showed a significant difference between the two groups (P= .749 and P= .068, respectively). If the inferior SBS was torn, a high frequency of pseudoparalysis was noted (81.0%, P= .010). The disruption of transverse force couple was noted in both irreparable mRCT groups, although no significant difference was found between the nonpseudoparalysis and pseudoparalysis groups. ISP and inferior SBS muscle volumes showed a significant decrease in pseudoparalysis group and, therefore, were considered to greatly influence the loss of active motion in mRCT. The TM did not exert significant effect on the incidence of pseudoparalysis. Copyright © 2017 Journal of Shoulder and Elbow Surgery Board of Trustees. Published by Elsevier Inc. All rights reserved.

Research perspectives in the field of ground penetrating radars in Armenia

NASA Astrophysics Data System (ADS)

Baghdasaryan, Hovik; Knyazyan, Tamara; Hovhannisyan, Tamara

2014-05-01

Armenia is a country located in a very complicated region from geophysical point of view. It is situated on a cross of several tectonic plates and a lot of dormant volcanoes. The main danger is earthquakes and the last big disaster was in 1988 in the northwest part of contemporary Armenia. As a consequence, the main direction of geophysical research is directed towards monitoring and data analysis of seismic activity. National Academy of Sciences of Armenia is conducting these activities in the Institute of Geological Sciences and in the Institute of Geophysics and Engineering Seismology. Research in the field of ground penetrating radars is considered in Armenia as an advanced and perspective complement to the already exploiting research tools. The previous achievements of Armenia in the fields of radiophysics, antenna measurements, laser physics and existing relevant research would permit to initiate new promising area of research in the direction of theory and experiments of ground penetrating radars. One of the key problems in the operation of ground penetrating radars is correct analysis of peculiarities of electromagnetic wave interaction with different layers of the earth. For this, the well-known methods of electromagnetic boundary problem solutions are applied. In addition to the existing methods our research group of Fiber Optics Communication Laboratory at the State Engineering University of Armenia declares its interest in exploring the possibilities of new non-traditional method of boundary problems solution for electromagnetic wave interaction with the ground. This new method for solving boundary problems of electrodynamics is called the method of single expression (MSE) [1-3]. The distinctive feature of this method is denial from the presentation of wave equation's solution in the form of counter-propagating waves, i.e. denial from the superposition principal application. This permits to solve linear and nonlinear (field intensity-dependent) problems with the same exactness, without any approximations. It is favourable also since in solution of boundary problems in the MSE there is no necessity in applying absorbing boundary conditions at the model edges by terminating the computational domain. In the MSE the computational process starts from the rear side of any multilayer structure that ensures the uniqueness of problem solution without application of any artificial absorbing boundary conditions. Previous success of the MSE application in optical domain gives us confidence in successful extension of this method's use for solution of different problems related to electromagnetic wave interaction with the layers of the earth and buried objects in the ground. This work benefited from networking activities carried out within the EU funded COST Action TU1208 "Civil Engineering Applications of Ground Penetrating Radar." 1. H.V. Baghdasaryan, T.M. Knyazyan, 'Problem of Plane EM Wave Self-action in Multilayer Structure: an Exact Solution', Optical and Quantum Electronics, vol. 31, 1999, pp.1059-1072. 2. H.V. Baghdasaryan, T.M. Knyazyan, 'Modelling of strongly nonlinear sinusoidal Bragg gratings by the Method of Single Expression', Optical and Quantum Electronics, vol. 32, 2000, pp. 869-883. 3. H.V. Baghdasaryan, 'Basics of the Method of Single Expression: New Approach for Solving Boundary Problems in Classical Electrodynamics', Yerevan, Chartaraget, 2013.

Cavity mode enhancement of terahertz emission from equilateral triangular microstrip antennas of the high-T c superconductor Bi2Sr2CaCu2O8 + δ.

PubMed

Cerkoney, Daniel P; Reid, Candy; Doty, Constance M; Gramajo, Ashley; Campbell, Tyler D; Morales, Manuel A; Delfanazari, Kaveh; Tsujimoto, Manabu; Kashiwagi, Takanari; Yamamoto, Takashi; Watanabe, Chiharu; Minami, Hidetoshi; Kadowaki, Kazuo; Klemm, Richard A

2017-01-11

We study the transverse magnetic (TM) electromagnetic cavity mode wave functions for an ideal equilateral triangular microstrip antenna (MSA) exhibiting C 3v point group symmetry. When the C 3v operations are imposed upon the antenna, the TM(m,n) modes with wave vectors [Formula: see text] are much less dense than commonly thought. The R 3 operations restrict the integral n and m to satisfy [Formula: see text], where [Formula: see text] and [Formula: see text] for the modes even and odd under reflections about the three mirror planes, respectively. We calculate the forms of representative wave functions and the angular dependence of the output power when these modes are excited by the uniform and non-uniform ac Josephson current sources in thin, ideally equilateral triangular MSAs employing the intrinsic Josephson junctions in the high transition temperature T c superconductor Bi 2 Sr 2 CaCu 2 [Formula: see text], and fit the emissions data from an earlier sample for which the C 3v symmetry was apparently broken.

Polarization-insensitive optical gain characteristics of highly stacked InAs/GaAs quantum dots

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kita, Takashi; Suwa, Masaya; Kaizu, Toshiyuki

2014-06-21

The polarized optical gain characteristics of highly stacked InAs/GaAs quantum dots (QDs) with a thin spacer layer fabricated on an n{sup +}-GaAs (001) substrate were studied in the sub-threshold gain region. Using a 4.0-nm-thick spacer layer, we realized an electronically coupled QD superlattice structure along the stacking direction, which enabled the enhancement of the optical gain of the [001] transverse-magnetic (TM) polarization component. We systematically studied the polarized electroluminescence properties of laser devices containing 30 and 40 stacked InAs/GaAs QDs. The net modal gain was analyzed using the Hakki-Paoli method. Owing to the in-plane shape anisotropy of QDs, the polarizationmore » sensitivity of the gain depends on the waveguide direction. The gain showing polarization isotropy between the TM and transverse-electric polarization components is high for the [110] waveguide structure, which occurs for higher amounts of stacked QDs. Conversely, the isotropy of the [−110] waveguide is easily achieved even if the stacking is relatively low, although the gain is small.« less

Oblique scattering from radially inhomogeneous dielectric cylinders: An exact Volterra integral equation formulation

NASA Astrophysics Data System (ADS)

Tsalamengas, John L.

2018-07-01

We study plane-wave electromagnetic scattering by radially and strongly inhomogeneous dielectric cylinders at oblique incidence. The method of analysis relies on an exact reformulation of the underlying field equations as a first-order 4 × 4 system of differential equations and on the ability to restate the associated initial-value problem in the form of a system of coupled linear Volterra integral equations of the second kind. The integral equations so derived are discretized via a sophisticated variant of the Nyström method. The proposed method yields results accurate up to machine precision without relying on approximations. Numerical results and case studies ably demonstrate the efficiency and high accuracy of the algorithms.

Gravitational waves in ghost free bimetric gravity

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mohseni, Morteza, E-mail: m-mohseni@pnu.ac.ir

2012-11-01

We obtain a set of exact gravitational wave solutions for the ghost free bimetric theory of gravity. With a flat reference metric, the theory admits the vacuum Brinkmann plane wave solution for suitable choices of the coefficients of different terms in the interaction potential. An exact gravitational wave solution corresponding to a massive scalar mode is also admitted for arbitrary choice of the coefficients with the reference metric being proportional to the spacetime metric. The proportionality factor and the speed of the wave are calculated in terms of the parameters of the theory. We also show that a F(R) extensionmore » of the theory admits similar solutions but in general is plagued with ghost instabilities.« less

In situ Proteomic Profiling of Curcumin Targets in HCT116 Colon Cancer Cell Line.

PubMed

Wang, Jigang; Zhang, Jianbin; Zhang, Chong-Jing; Wong, Yin Kwan; Lim, Teck Kwang; Hua, Zi-Chun; Liu, Bin; Tannenbaum, Steven R; Shen, Han-Ming; Lin, Qingsong

2016-02-26

To date, the exact targets and mechanism of action of curcumin, a natural product with anti-inflammatory and anti-cancer properties, remain elusive. Here we synthesized a cell permeable curcumin probe (Cur-P) with an alkyne moiety, which can be tagged with biotin for affinity enrichment, or with a fluorescent dye for visualization of the direct-binding protein targets of curcumin in situ. iTRAQ(TM) quantitative proteomics approach was applied to distinguish the specific binding targets from the non-specific ones. In total, 197 proteins were confidently identified as curcumin binding targets from HCT116 colon cancer cell line. Gene Ontology analysis showed that the targets are broadly distributed and enriched in the nucleus, mitochondria and plasma membrane, and they are involved in various biological functions including metabolic process, regulation, response to stimulus and cellular process. Ingenuity Pathway Analysis(TM) (IPA) suggested that curcumin may exert its anticancer effects over multiple critical biological pathways including the EIF2, eIF4/p70S6K, mTOR signaling and mitochondrial dysfunction pathways. Functional validations confirmed that curcumin downregulates cellular protein synthesis, and induces autophagy, lysosomal activation and increased ROS production, thus leading to cell death.

Optical properties of honeycomb photonic structures

NASA Astrophysics Data System (ADS)

Sinelnik, Artem D.; Rybin, Mikhail V.; Lukashenko, Stanislav Y.; Limonov, Mikhail F.; Samusev, Kirill B.

2017-06-01

We study, theoretically and experimentally, optical properties of different types of honeycomb photonic structures, known also as "photonic graphene." First, we employ the two-photon polymerization method to fabricate the honeycomb structures. In the experiment, we observe a strong diffraction from a finite number of elements, thus providing a unique tool to define the exact number of scattering elements in the structure with the naked eye. Next, we study theoretically the transmission spectra of both honeycomb single layer and two-dimensional (2D) structures of parallel dielectric circular rods. When the dielectric constant of the rod materials ɛ is increasing, we reveal that a 2D photonic graphene structure transforms into a metamaterial when the lowest TE 01 Mie gap opens up below the lowest Bragg band gap. We also observe two Dirac points in the band structure of 2D photonic graphene at the K point of the Brillouin zone and demonstrate a manifestation of Dirac lensing for the TM polarization. The performance of the Dirac lens is that the 2D photonic graphene layer converts a wave from point source into a beam with flat phase surfaces at the Dirac frequency for the TM polarization.

A 94 GHz imaging array using slot line radiators. Ph.D. Thesis

NASA Technical Reports Server (NTRS)

Korzeniowski, T. L.

1985-01-01

A planar endfire slotted-line antenna structure was investigated. It was found that the H-plane beamwidths are basically dependent upon the substrate properties, whereas the E-plane beamwidths are more strongly a function of the slot's shape and size. It is shown that these antennas produce symmetrical E and H-plane beamwidths while following Zucker's standard traveling-wave antenna beamwidth curves over some range of antenna normalized length. An empircally derived design formula for effective substrate thickness is shown to predict this range for linearly tapered slotted-line antennas. The experimental imaging properties of these arrays are presented and imaging theory is discussed. It is shown that a minimum spacing of elements is necessary for exact reconstruction for a sampled image in a diffraction limited system. Because these LTSA elements employ the traveling-wave mechanism of radiation, they can be spaced two times closer than a conical feed horn of comparable beamwidth.

Penetration of sunlight into a canopy - Explicit models based on vertical and horizontal leaf projections

NASA Technical Reports Server (NTRS)

Otterman, J.; Brakke, T.

1986-01-01

The projections of leaf areas onto a horizontal plane and onto a vertical plane are examined for their utility in characterizing canopies for sunlight penetration (direct beam only) models. These projections exactly specify the penetration if the projections on the principal plane of the normals to the top surfaces of the leaves are in the same quadrant as the sun. Inferring the total leaf area from these projections (and therefore the penetration as a function of the total leaf area) is possible only with a large uncertainty (up to + or - 32 percent) because the projections are a specific measure of the total leaf area only if the leaf angle distribution is known. It is expected that this uncertainty could be reduced to more acceptable levels by making an approximate assessment of whether the zenith angle distribution is that of an extremophile canopy.

Solutions of differential equations with regular coefficients by the methods of Richmond and Runge-Kutta

NASA Technical Reports Server (NTRS)

Cockrell, C. R.

1989-01-01

Numerical solutions of the differential equation which describe the electric field within an inhomogeneous layer of permittivity, upon which a perpendicularly-polarized plane wave is incident, are considered. Richmond's method and the Runge-Kutta method are compared for linear and exponential profiles of permittivities. These two approximate solutions are also compared with the exact solutions.

Second-order numerical solution of time-dependent, first-order hyperbolic equations

NASA Technical Reports Server (NTRS)

Shah, Patricia L.; Hardin, Jay

1995-01-01

A finite difference scheme is developed to find an approximate solution of two similar hyperbolic equations, namely a first-order plane wave and spherical wave problem. Finite difference approximations are made for both the space and time derivatives. The result is a conditionally stable equation yielding an exact solution when the Courant number is set to one.

Analytical model of a corona discharge from a conical electrode under saturation

NASA Astrophysics Data System (ADS)

Boltachev, G. Sh.; Zubarev, N. M.

2012-11-01

Exact partial solutions are found for the electric field distribution in the outer region of a stationary unipolar corona discharge from an ideal conical needle in the space-charge-limited current mode with allowance for the electric field dependence of the ion mobility. It is assumed that only the very tip of the cone is responsible for the discharge, i.e., that the ionization zone is a point. The solutions are obtained by joining the spherically symmetric potential distribution in the drift space and the self-similar potential distribution in the space-charge-free region. Such solutions are outside the framework of the conventional Deutsch approximation, according to which the space charge insignificantly influences the shape of equipotential surfaces and electric lines of force. The dependence is derived of the corona discharge saturation current on the apex angle of the conical electrode and applied potential difference. A simple analytical model is suggested that describes drift in the point-plane electrode geometry under saturation as a superposition of two exact solutions for the field potential. In terms of this model, the angular distribution of the current density over the massive plane electrode is derived, which agrees well with Warburg's empirical law.

Direct determination of k Q factors for cylindrical and plane-parallel ionization chambers in high-energy electron beams from 6 MeV to 20 MeV.

PubMed

Krauss, A; Kapsch, R-P

2018-02-06

For the ionometric determination of the absorbed dose to water, D w , in high-energy electron beams from a clinical accelerator, beam quality dependent correction factors, k Q , are required. By using a water calorimeter, these factors can be determined experimentally and potentially with lower standard uncertainties than those of the calculated k Q factors, which are tabulated in various dosimetry protocols. However, one of the challenges of water calorimetry in electron beams is the small measurement depths in water, together with the steep dose gradients present especially at lower energies. In this investigation, water calorimetry was implemented in electron beams to determine k Q factors for different types of cylindrical and plane-parallel ionization chambers (NE2561, NE2571, FC65-G, TM34001) in 10 cm  ×  10 cm electron beams from 6 MeV to 20 MeV (corresponding beam quality index R 50 ranging from 1.9 cm to 7.5 cm). The measurements were carried out using the linear accelerator facility of the Physikalisch-Technische Bundesanstalt. Relative standard uncertainties for the k Q factors between 0.50% for the 20 MeV beam and 0.75% for the 6 MeV beam were achieved. For electron energies above 8 MeV, general agreement was found between the relative electron energy dependencies of the k Q factors measured and those derived from the AAPM TG-51 protocol and recent Monte Carlo-based studies, as well as those from other experimental investigations. However, towards lower energies, discrepancies of up to 2.0% occurred for the k Q factors of the TM34001 and the NE2571 chamber.

Direct determination of k Q factors for cylindrical and plane-parallel ionization chambers in high-energy electron beams from 6 MeV to 20 MeV

NASA Astrophysics Data System (ADS)

Krauss, A.; Kapsch, R.-P.

2018-02-01

For the ionometric determination of the absorbed dose to water, D w, in high-energy electron beams from a clinical accelerator, beam quality dependent correction factors, k Q, are required. By using a water calorimeter, these factors can be determined experimentally and potentially with lower standard uncertainties than those of the calculated k Q factors, which are tabulated in various dosimetry protocols. However, one of the challenges of water calorimetry in electron beams is the small measurement depths in water, together with the steep dose gradients present especially at lower energies. In this investigation, water calorimetry was implemented in electron beams to determine k Q factors for different types of cylindrical and plane-parallel ionization chambers (NE2561, NE2571, FC65-G, TM34001) in 10 cm  ×  10 cm electron beams from 6 MeV to 20 MeV (corresponding beam quality index R 50 ranging from 1.9 cm to 7.5 cm). The measurements were carried out using the linear accelerator facility of the Physikalisch-Technische Bundesanstalt. Relative standard uncertainties for the k Q factors between 0.50% for the 20 MeV beam and 0.75% for the 6 MeV beam were achieved. For electron energies above 8 MeV, general agreement was found between the relative electron energy dependencies of the k Q factors measured and those derived from the AAPM TG-51 protocol and recent Monte Carlo-based studies, as well as those from other experimental investigations. However, towards lower energies, discrepancies of up to 2.0% occurred for the k Q factors of the TM34001 and the NE2571 chamber.

On the Propagation of Plane Acoustic Waves in a Duct With Flexible and Impedance Walls

NASA Technical Reports Server (NTRS)

Frendi, Abdelkader; Vu, Bruce

2003-01-01

This Technical Memorandum (TM) discusses the harmonic and random plane acoustic waves propagating from inside a duct to its surroundings. Various duct surfaces are considered, such as rigid, flexible, and impedance. In addition, the effects of a mean flow are studied when the duct alone is considered. Results show a significant reduction in overall sound pressure levels downstream of the impedance wall for both mean flow and no mean flow cases and for a narrow duct. When a wider duct is used, the overall sound pressure level (OSPL) reduction downstream of the impedance wall is much smaller. In the far field, the directivity is such that the overall sound pressure level is reduced by about 5 decibels (dB) on the side of the impedance wall. When a flexible surface is used, the far field directivity becomes asymmetric with an increase in the OSPL on the side of the flexible surface of about 7 dB.

Simulation of subwavelength metallic gratings using a new implementation of the recursive convolution finite-difference time-domain algorithm.

PubMed

Banerjee, Saswatee; Hoshino, Tetsuya; Cole, James B

2008-08-01

We introduce a new implementation of the finite-difference time-domain (FDTD) algorithm with recursive convolution (RC) for first-order Drude metals. We implemented RC for both Maxwell's equations for light polarized in the plane of incidence (TM mode) and the wave equation for light polarized normal to the plane of incidence (TE mode). We computed the Drude parameters at each wavelength using the measured value of the dielectric constant as a function of the spatial and temporal discretization to ensure both the accuracy of the material model and algorithm stability. For the TE mode, where Maxwell's equations reduce to the wave equation (even in a region of nonuniform permittivity) we introduced a wave equation formulation of RC-FDTD. This greatly reduces the computational cost. We used our methods to compute the diffraction characteristics of metallic gratings in the visible wavelength band and compared our results with frequency-domain calculations.

Exact solution for an optimal impermeable parachute problem

NASA Astrophysics Data System (ADS)

Lupu, Mircea; Scheiber, Ernest

2002-10-01

In the paper there are solved direct and inverse boundary problems and analytical solutions are obtained for optimization problems in the case of some nonlinear integral operators. It is modeled the plane potential flow of an inviscid, incompressible and nonlimited fluid jet, witch encounters a symmetrical, curvilinear obstacle--the deflector of maximal drag. There are derived integral singular equations, for direct and inverse problems and the movement in the auxiliary canonical half-plane is obtained. Next, the optimization problem is solved in an analytical manner. The design of the optimal airfoil is performed and finally, numerical computations concerning the drag coefficient and other geometrical and aerodynamical parameters are carried out. This model corresponds to the Helmholtz impermeable parachute problem.

The Effect of Viscosity of a Fluid on the Frequency Response of a Viscoelastic Plate Loaded by This Fluid

NASA Astrophysics Data System (ADS)

Zamanov, A. D.; Ismailov, M. I.; Akbarov, S. D.

2018-03-01

A hydroviscoelastic system consisting of a viscoelastic plate and a half-plane filled with a viscous fluid is considered. The effect of viscosity of the fluid on the frequency response of the system and its dependence on the rheological parameters of plate material are estimated. The problem on forced vibrations of the system in the plane strain state is investigated using the exact equations of viscoelastodynamics for describing the motion of the plate and linearized Navier-Stokes equations for describing the flow of the fluid. The results found in the cases of nonviscous compressible and Newtonian compressible viscous fluids are compared.

Conformal Collineations of the Ricci and Energy-Momentum Tensors in Static Plane Symmetric Space-Times

NASA Astrophysics Data System (ADS)

Akhtar, S. S.; Hussain, T.; Bokhari, A. H.; Khan, F.

2018-04-01

We provide a complete classification of static plane symmetric space-times according to conformal Ricci collineations (CRCs) and conformal matter collineations (CMCs) in both the degenerate and nondegenerate cases. In the case of a nondegenerate Ricci tensor, we find a general form of the vector field generating CRCs in terms of unknown functions of t and x subject to some integrability conditions. We then solve the integrability conditions in different cases depending upon the nature of the Ricci tensor and conclude that the static plane symmetric space-times have a 7-, 10- or 15-dimensional Lie algebra of CRCs. Moreover, we find that these space-times admit an infinite number of CRCs if the Ricci tensor is degenerate. We use a similar procedure to study CMCs in the case of a degenerate or nondegenerate matter tensor. We obtain the exact form of some static plane symmetric space-time metrics that admit nontrivial CRCs and CMCs. Finally, we present some physical applications of our obtained results by considering a perfect fluid as a source of the energy-momentum tensor.

Effects of Landsat 5 Thematic Mapper and Landsat 7 Enhanced Thematic Mapper plus radiometric and geometric calibrations and corrections on landscape characterization

USGS Publications Warehouse

Vogelmann, James E.; Helder, Dennis; Morfitt, Ron; Choate, Michael J.; Merchant, James W.; Bulley, Henry

2001-01-01

The Thematic Mapper (TM) instruments onboard Landsats 4 and 5 provide high-quality imagery appropriate for many different applications, including land cover mapping, landscape ecology, and change detection. Precise calibration was considered to be critical to the success of the Landsat 7 mission and, thus, issues of calibration were given high priority during the development of the Enhanced Thematic Mapper Plus (ETM+). Data sets from the Landsat 5 TM are not routinely corrected for a number of radiometric and geometric artifacts, including memory effect, gain/bias, and interfocal plane misalignment. In the current investigation, the effects of correcting vs. not correcting these factors were investigated for several applications. Gain/bias calibrations were found to have a greater impact on most applications than did memory effect calibrations. Correcting interfocal plane offsets was found to have a moderate effect on applications. On June 2, 1999, Landsats 5 and 7 data were acquired nearly simultaneously over a study site in the Niobrara, NE area. Field radiometer data acquired at that site were used to facilitate crosscalibrations of Landsats 5 and 7 data. Current findings and results from previous investigations indicate that the internal calibrator of Landsat 5 TM tracked instrument gain well until 1988. After this, the internal calibrator diverged from the data derived from vicarious calibrations. Results from this study also indicate very good agreement between prelaunch measurements and vicarious calibration data for all Landsat 7 reflective bands except Band 4. Values are within about 3.5% of each other, except for Band 4, which differs by 10%. Coefficient of variation (CV) values derived from selected targets in the imagery were also analyzed. The Niobrara Landsat 7 imagery was found to have lower CV values than Landsat 5 data, implying that lower levels of noise characterize Landsat 7 data than current Landsat 5 data. It was also found that following radiometric normalization, the Normalized Difference Vegetation Index (NDVI) imagery and classification products of Landsats 5 and 7 were very similar. This implies that data from the two sensors can be used to measure and monitor the same landscape phenomena and that Landsats 5 and 7 data can be used interchangeably with proper caution. In addition, it was found that difference imagery produced using Landsat 7 ETM+ data are of excellent quality.

Simple Schlieren Light Meter

NASA Technical Reports Server (NTRS)

Rhodes, David B.; Franke, John M.; Jones, Stephen B.; Leighty, Bradley D.

1992-01-01

Simple light-meter circuit used to position knife edge of schlieren optical system to block exactly half light. Enables operator to check quickly position of knife edge between tunnel runs to ascertain whether or not in alignment. Permanent measuring system made part of each schlieren system. If placed in unused area of image plane, or in monitoring beam from mirror knife edge, provides real-time assessment of alignment of schlieren system.

Annotated Bibliography of Sediment Transport Occurring over Ebb-Tidal Deltas.

DTIC Science & Technology

1985-09-01

and trough cross stratification from the shallower channel, should be expected. Swash-generated, horizontal plane laminations or * slightly inclined... laminations from the shallow channel sides. Transitional inlets would produce a variety of sequences, the exact nature of which would reflect the relative...and tidal currents. The beach face is characterized by flatbeds and antidunes; the runnel contains cuspate megaripples and current ripples oriented

Photoacoustic tomography using a fiber based Fabry-Perot interferometer as an integrating line detector and image reconstruction by model-based time reversal method

NASA Astrophysics Data System (ADS)

Grün, H.; Paltauf, G.; Haltmeier, M.; Burgholzer, P.

2007-07-01

Photoacoustic imaging is based on the generation of acoustic waves in a semitransparent sample (e.g. soft tissue) after illumination with short pulses of light or radio waves. The goal is to recover the spatial distribution of absorbed energy density inside the sample from acoustic pressure signals measured outside the sample (photoacoustic inverse problem). If the acoustic pressure outside the illuminated sample is measured with a large-aperture detector, the signal at a certain time is given by an integral of the generated acoustic pressure distribution over an area that is determined by the shape of the detector. For example a planar detector measures the projections of the initial pressure distribution over planes parallel to the detector plane, which is the Radon transform of the initial pressure distribution. Stable and exact three-dimensional imaging with planar integrating detector requires measurements in all directions of space and so the receiver plane has to be rotated to cover the entire detection surface. We have recently presented a simpler set-up for exact imaging which requires only a single rotation axis and therefor the fragmentation of the area detector into line detectors perpendicular to the rotation axis. Using a two-dimensional reconstruction method and applying the inverse two-dimensional Radon transform afterwards gives an exact reconstruction of the three-dimensional sample with this set-up. In order to achieve high resolution, a fiber based Fabry-Perot interferometer is used. It is a single mode fiber with two fiber bragg gratings on both ends of the line detector. Thermal shifts and vibrations are compensated by frequency locking of the laser. The high resolution and the good performance of this integrating line detector has been demonstrated by photoacoustic measurements with line grid samples and phantoms using a model-based time reversal method for image reconstruction. The time reversed pressure field can be calculated directly by retransmitting the measured pressure on the detector positions in a reversed temporal order.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Barnes, Taylor A.; Kurth, Thorsten; Carrier, Pierre

Here, we present an algorithm and implementation for the parallel computation of exact exchange in Quantum ESPRESSO (QE) that exhibits greatly improved strong scaling. QE is an open-source software package for electronic structure calculations using plane wave density functional theory, and supports the use of local, semi-local, and hybrid DFT functionals. Wider application of hybrid functionals is desirable for the improved simulation of electronic band energy alignments and thermodynamic properties, but the computational complexity of evaluating the exact exchange potential limits the practical application of hybrid functionals to large systems and requires efficient implementations. We demonstrate that existing implementations ofmore » hybrid DFT that utilize a single data structure for both the local and exact exchange regions of the code are significantly limited in the degree of parallelization achievable. We present a band-pair parallelization approach, in which the calculation of exact exchange is parallelized and evaluated independently from the parallelization of the remainder of the calculation, with the wavefunction data being efficiently transformed on-the-fly into a form that is optimal for each part of the calculation. For a 64 water molecule supercell, our new algorithm reduces the overall time to solution by nearly an order of magnitude.« less

Exact exchange potential for slabs: Asymptotic behavior of the Krieger-Li-Iafrate approximation

NASA Astrophysics Data System (ADS)

Engel, Eberhard

2018-02-01

The Krieger-Li-Iafrate (KLI) approximation for the exact exchange (EXX) potential of density functional theory is investigated far outside the surface of slabs. For large z the Slater component of the EXX/KLI potential falls off as -1 /z , where z is the distance to the surface of a slab parallel to the x y plane. The Slater potential thus reproduces the behavior of the exact EXX potential. Here it is demonstrated that the second component of the EXX/KLI potential, often called the orbital-shift term, is also proportional to 1 /z for large z , at least in general. This result is obtained by an analytical evaluation of the Brillouin zone integrals involved, relying on the exponential decay of the states into the vacuum. Several situations need to be distinguished in the Brillouin zone integration, depending on the band structure of the slab. In all standard situations, including such prominent cases as graphene and Si(111) slabs, however, a 1 /z dependence of the orbital-shift potential is obtained to leading order. The complete EXX/KLI potential therefore does not reproduce the asymptotic behavior of the exact EXX potential.

Sex differences in lower extremity kinematics and patellofemoral kinetics during running.

PubMed

Almonroeder, Thomas G; Benson, Lauren C

2017-08-01

The incidence of patellofemoral pain (PFP) is 2 times greater in females compared with males of similar activity levels; however, the exact reason for this discrepancy remains unclear. Abnormal mechanics of the hip and knee in the sagittal, frontal, and transverse planes have been associated with an increased risk of PFP. The purpose of this study was to compare the mechanics of the lower extremity in males and females during running in order to better understand the reason(s) behind the sex discrepancy in PFP. Three-dimensional kinematic and kinetic data were collected as male and female participants completed overground running trials at a speed of 4.0 m · s -1 (±5%). Patellofemoral joint stress (PFJS) was estimated using a sagittal plane knee model. The kinematics of the hip and knee in the frontal and transverse planes were also analysed. Male participants demonstrated significantly greater sagittal plane peak PFJS in comparison with the female participants (P < .001, ES = 1.9). However, the female participants demonstrated 3.5° greater peak hip adduction and 3.4° greater peak hip internal rotation (IR). As a result, it appears that the sex discrepancy in PFP is more likely to be related to differences in the kinematics of the hip in the frontal and transverse planes than differences in sagittal plane PFJS.

Asymptotic distributions of coalescence times and ancestral lineage numbers for populations with temporally varying size.

PubMed

Chen, Hua; Chen, Kun

2013-07-01

The distributions of coalescence times and ancestral lineage numbers play an essential role in coalescent modeling and ancestral inference. Both exact distributions of coalescence times and ancestral lineage numbers are expressed as the sum of alternating series, and the terms in the series become numerically intractable for large samples. More computationally attractive are their asymptotic distributions, which were derived in Griffiths (1984) for populations with constant size. In this article, we derive the asymptotic distributions of coalescence times and ancestral lineage numbers for populations with temporally varying size. For a sample of size n, denote by Tm the mth coalescent time, when m + 1 lineages coalesce into m lineages, and An(t) the number of ancestral lineages at time t back from the current generation. Similar to the results in Griffiths (1984), the number of ancestral lineages, An(t), and the coalescence times, Tm, are asymptotically normal, with the mean and variance of these distributions depending on the population size function, N(t). At the very early stage of the coalescent, when t → 0, the number of coalesced lineages n - An(t) follows a Poisson distribution, and as m → n, $$n\\left(n-1\\right){T}_{m}/2N\\left(0\\right)$$ follows a gamma distribution. We demonstrate the accuracy of the asymptotic approximations by comparing to both exact distributions and coalescent simulations. Several applications of the theoretical results are also shown: deriving statistics related to the properties of gene genealogies, such as the time to the most recent common ancestor (TMRCA) and the total branch length (TBL) of the genealogy, and deriving the allele frequency spectrum for large genealogies. With the advent of genomic-level sequencing data for large samples, the asymptotic distributions are expected to have wide applications in theoretical and methodological development for population genetic inference.

In silico analysis of high affinity potassium transporter (HKT) isoforms in different plants

PubMed Central

2014-01-01

Background High affinity potassium transporters (HKTs) are located in the plasma membrane of the vessels and have significant influence on salt tolerance in some plants. They exclude Na+ from the parenchyma cells to reduce Na+ concentration. Despite many studies, the underlying regulatory mechanisms and the exact functions of HKTs within different genomic backgrounds are relatively unknown. In this study, various bioinformatics techniques, including promoter analysis, identification of HKT-surrounding genes, and construction of gene networks, were applied to investigate the HKT regulatory mechanism. Results Promoter analysis showed that rice HKTs carry ABA response elements. Additionally, jasmonic acid response elements were detected on promoter region of TmHKT1;5. In silico synteny highlighted several unknown and new loci near rice, Arabidopsis thaliana and Physcomitrella patent HKTs, which may play a significant role in salt stress tolerance in concert with HKTs. Gene network prediction unravelled that crosstalk between jasmonate and ethylene reduces AtHKT1;1 expression. Furthermore, antiporter and transferase proteins were found in AtHKT1;1 gene network. Interestingly, regulatory elements on the promoter region of HKT in wild genotype (TmHKT1;5) were more frequent and variable than the ones in cultivated wheat (TaHKT1;5) which provides the possibility of rapid response and better understanding of environmental conditions for wild genotype. Conclusion Detecting ABA and jasmonic acid response elements on promoter regions of HKTs provide valuable clues on underlying regulatory mechanisms of HKTs. In silico synteny and pathway discovery indicated several candidates which act in concert with HKTs in stress condition. We highlighted different arrangement of regulatory elements on promoter region of wild wheat (TmHKT1;5) compared to bread wheat (TaHKT1;5) in this study. PMID:25279141

Febuxostat attenuates paroxysmal atrial fibrillation-induced regional endothelial dysfunction.

PubMed

Li, YanGuang; Chen, FuKun; Deng, Long; Lin, Kun; Shi, Xiangmin; Zhaoliang, Shan; Wang, YuTang

2017-01-01

Paroxysmal atrial fibrillation (PAF) can increase thrombogenesis risk, especially in the left atrium (LA). The exact mechanism is still unclear. We assessed the effects of PAF on endothelial function, and investigated if febuxostat (FX) can attenuate endothelial dysfunction by inhibition of xanthine oxidase (XO). Eighteen male New Zealand white rabbits were divided randomly into sham-operated (S), PAF (P) or FX+pacing (FP) groups. Group P and group FP received rapid atrial pacing (RAP). Group FP was administered febuxostat (FX) for 7days before RAP. Post-procedure, blood samples were collected from the LA, right atrium (RA) and peripheral circulation. Tissues from the LA and RA were obtained. Endothelial dysfunction (thrombomodulin [TM], von Willebrand factor [VWF], asymmetric dimethylarginine [ADMA]), and indirect thrombin generation (thrombin-antithrombin complex [TAT], prothrombin fragment 1+2 [F1.2]) and oxidative stress in atrial tissue (xanthine oxidase [XO], superoxide dismutase [SOD], malondialdehyde [MDA]) were measured using an Enzyme-linked immunosorbent assay. Atrial endothelial expression of TM and VWF was measured by histology/western blotting. Endothelial dysfunction (TM, VWF, ADMA), TAT generation and oxidative stress (XO, SOD, MDA) in group P were more significant compared with that in group S (p<0.05, respectively). In group P, all of these changes occurred to a greater extent in the LA compared with those in the RA or peripheral circulation. In group FP, FX attenuated endothelial dysfunction and reduced TAT levels by inhibition of XO-mediated oxidative stress. PAF can lead to endothelial dysfunction and TAT generation by XO-mediated oxidative stress. The LA is more susceptible to these effects. FX can attenuate these changes by inhibition XO and XO-mediated oxidative stress. Copyright © 2016. Published by Elsevier Ltd.

Spin Waves and Transport Properties in Ferromagnetic Co-Al-O and Fe-Al-O Granular Films: A Brillouin Scattering Study

NASA Astrophysics Data System (ADS)

Yoshihara, Akira; Ohnuma, Shigehiro; Fujimori, Hiroyasu; Nakamura, Shintaro; Nojima, Tsutomu

2008-09-01

A systematic Brillouin light scattering (BLS) study on long-wavelength spin waves (SWs) in ferromagnetic TM-Al-O (TM=Co, Fe) nano-granular films with thickness of >1 μm was performed under magnetic fields of up to 4 kOe at room temperature. BLS spectra consist of a pair of bulk SW peaks on both frequency sides and a surface localized SW peak only on the positive frequency side in this study. These SW frequencies as a function of the magnetic field can be fully reproduced by the magnetostatic frequency formula developed for a semi-infinite uniform ferromagnetic medium with an exchange coupling and an in-plane uniaxial magnetic anisotropy. We determined a set of the magnetic constants including the exchange field HE for each film. Combining the exchange field HE with the electrical resistivity ρ for each film at room temperature, we found an inverse-square law given by ρ=a(HE)-2 for both the Co and Fe granular films with aFe=30.3 μΩ\\cdotcm\\cdot(kOe)2 and aCo=22.1 μΩ\\cdotcm\\cdot(kOe)2, respectively.

Cavity mode enhancement of terahertz emission from equilateral triangular microstrip antennas of the high-T c superconductor Bi2Sr2CaCu2O8 + δ

NASA Astrophysics Data System (ADS)

Cerkoney, Daniel P.; Reid, Candy; Doty, Constance M.; Gramajo, Ashley; Campbell, Tyler D.; Morales, Manuel A.; Delfanazari, Kaveh; Tsujimoto, Manabu; Kashiwagi, Takanari; Yamamoto, Takashi; Watanabe, Chiharu; Minami, Hidetoshi; Kadowaki, Kazuo; Klemm, Richard A.

2017-01-01

We study the transverse magnetic (TM) electromagnetic cavity mode wave functions for an ideal equilateral triangular microstrip antenna (MSA) exhibiting C 3v point group symmetry. When the C 3v operations are imposed upon the antenna, the TM(m,n) modes with wave vectors \\propto \\sqrt{{{m}2}+nm+{{n}2}} are much less dense than commonly thought. The R 3 operations restrict the integral n and m to satisfy |m-n| =3p , where p≥slant 0 and p≥slant 1 for the modes even and odd under reflections about the three mirror planes, respectively. We calculate the forms of representative wave functions and the angular dependence of the output power when these modes are excited by the uniform and non-uniform ac Josephson current sources in thin, ideally equilateral triangular MSAs employing the intrinsic Josephson junctions in the high transition temperature T c superconductor Bi2Sr2CaCu2 {{\\text{O}}8+δ} , and fit the emissions data from an earlier sample for which the C 3v symmetry was apparently broken.

Transition metal intercalated bilayer silicene

NASA Astrophysics Data System (ADS)

Pandey, Dhanshree; Kamal, C.; Chakrabarti, Aparna

2018-04-01

We investigate the electronic and magnetic properties of Mn, Fe and Co-intercalated silicene bilayer with AA and AB stacking by using spin polarized density functional theory. The intercalation of Mn increases the gap between the two layers of silicene due to the larger atomic radii of Mn as compared to Fe and Co. Bader charge analysis has been performed to understand the bonding between the TM and Si atoms. This also helps in explaining the magnetic moment possessed by the composite systems after intercalating TM in between the layers of bilayer silicene system. This study reveals that a significant net magnetic moment is observed in cases of Mn-intercalated silicene bilayers, whereas Fe has a very small moment of 0.78 µB in the case of AA stacking configuration only. Co intercalation leads to net zero magnetic moment. Further, we find that Fe and Co marginally favor the AB stacking whereas Mn has a slight preference of the AA over the AB configuration. The composite systems, specifically when intercalated with Fe and Co atoms, favor a hybridization which is far away from sp3-like hybridization along the plane of Si atoms in bilayer silicene.

On investigating wall shear stress in two-dimensional plane turbulent wall jets

NASA Astrophysics Data System (ADS)

Mehdi, Faraz; Johansson, Gunnar; White, Christopher; Naughton, Jonathan

2012-11-01

Mehdi & White [Exp Fluids 50:43-51(2011)] presented a full momentum integral based method for determining wall shear stress in zero pressure gradient turbulent boundary layers. They utilized the boundary conditions at the wall and at the outer edge of the boundary layer. A more generalized expression is presented here that uses just one boundary condition at the wall. The method is mathematically exact and has an advantage of having no explicit streamwise gradient terms. It is successfully applied to two different experimental plane turbulent wall jet datasets for which independent estimates of wall shear stress were known. Complications owing to experimental inaccuracies in determining wall shear stress from the proposed method are also discussed.

Evidence for unnatural-parity contributions to electron-impact ionization of laser-aligned atoms

DOE PAGES

Armstrong, Gregory S. J.; Colgan, James Patrick; Pindzola, M. S.; ...

2015-09-11

Recent measurements have examined the electron-impact ionization of excited-state laser-aligned Mg atoms. In this paper we show that the ionization cross section arising from the geometry where the aligned atom is perpendicular to the scattering plane directly probes the unnatural parity contributions to the ionization amplitude. The contributions from natural parity partial waves cancel exactly in this geometry. Our calculations resolve the discrepancy between the nonzero measured cross sections in this plane and the zero cross section predicted by distorted-wave approaches. Finally, we demonstrate that this is a general feature of ionization from p-state targets by additional studies of ionizationmore » from excited Ca and Na atoms.« less

Strong spin-orbit effects in transition metal oxides with tetrahedral coordination

NASA Astrophysics Data System (ADS)

Forte, Filomena; Guerra, Delia; Autieri, Carmine; Romano, Alfonso; Noce, Canio; Avella, Adolfo

2018-05-01

To prove that spin-orbit coupling can play a relevant role in determining the magnetic structure of transition metal oxides with tetrahedral coordination, we investigate the d1 Mott insulator KOsO4, combining density functional theory calculations and the exact diagonalization approach. We find that the interplay between crystal field, strong spin-orbit coupling, electronic correlations and structural distortions brings the system towards an antiferromagnetic phase, characterized by a non-vanishing orbital angular momentum and anisotropy among the in-plane and the out-of-plane antiferromagnetic correlations. We also show that, due to the peculiar interplay between spin-orbit coupling, Hund's coupling and hopping connectivity the system is on the verge of developing short range ferromagnetic correlations marked by strong directionality.

Full thermomechanical coupling in modelling of micropolar thermoelasticity

NASA Astrophysics Data System (ADS)

Murashkin, E. V.; Radayev, Y. N.

2018-04-01

The present paper is devoted to plane harmonic waves of displacements and microrotations propagating in fully coupled thermoelastic continua. The analysis is carried out in the framework of linear conventional thermoelastic micropolar continuum model. The reduced energy balance equation and the special form of the Helmholtz free energy are discussed. The constitutive constants providing fully coupling of equations of motion and heat conduction are considered. The dispersion equation is derived and analysed in the form bi-cubic and bi-quadratic polynoms product. The equation are analyzed by the computer algebra system Mathematica. Algebraic forms expressed by complex multivalued square and cubic radicals are obtained for wavenumbers of transverse and longitudinal waves. The exact forms of wavenumbers of a plane harmonic coupled thermoelastic waves are computed.

Highly mobile type II twin boundary in Ni-Mn-Ga five-layered martensite

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sozinov, A.; Lanska, N.; Soroka, A.

2011-09-19

Twin relationships and stress-induced reorientation were studied in Ni{sub 2}Mn{sub 1.14}Ga{sub 0.86} single crystal with five-layered modulated martensite crystal structure. Very low twinning stress of about 0.1 MPa was found for twin boundaries which deviated a few degrees from the (011) crystallographic plane. However, twin boundaries oriented exactly parallel to the (011) plane exhibited considerably higher level of twinning stress, above 1 MPa. X-ray diffraction experiments and calculations based on approximation of the martensite crystal lattice as a tetragonal lattice with a slight monoclinic distortion identified the two different kinds of twin interfaces as type II and type I twinmore » boundaries.« less

Mill Glaze: Myth or Reality?

Treesearch

Mark Knaebe

2013-01-01

Since the mid-1980s, a condition called “mill glaze” (also called planer’s glaze) has sometimes been blamed for the failure of a coating on smooth flat-grained siding and some other wood products. The exact cause of this problem has been a subject of controversy. Many people believe that the coating fails as a result of the planing and/or drying processes. They...

Focusing of noncircular self-similar shock waves.

PubMed

Betelu, S I; Aronson, D G

2001-08-13

We study the focusing of noncircular shock waves in a perfect gas. We construct an explicit self-similar solution by combining three convergent plane waves with regular shock reflections between them. We then show, with a numerical Riemann solver, that there are initial conditions with smooth shocks whose intermediate asymptotic stage is described by the exact solution. Unlike the focusing of circular shocks, our self-similar shocks have bounded energy density.

Towards the stabilization of the low density elements in topology optimization with large deformation

NASA Astrophysics Data System (ADS)

Lahuerta, Ricardo Doll; Simões, Eduardo T.; Campello, Eduardo M. B.; Pimenta, Paulo M.; Silva, Emilio C. N.

2013-10-01

This work addresses the treatment of lower density regions of structures undergoing large deformations during the design process by the topology optimization method (TOM) based on the finite element method. During the design process the nonlinear elastic behavior of the structure is based on exact kinematics. The material model applied in the TOM is based on the solid isotropic microstructure with penalization approach. No void elements are deleted and all internal forces of the nodes surrounding the void elements are considered during the nonlinear equilibrium solution. The distribution of design variables is solved through the method of moving asymptotes, in which the sensitivity of the objective function is obtained directly. In addition, a continuation function and a nonlinear projection function are invoked to obtain a checkerboard free and mesh independent design. 2D examples with both plane strain and plane stress conditions hypothesis are presented and compared. The problem of instability is overcome by adopting a polyconvex constitutive model in conjunction with a suggested relaxation function to stabilize the excessive distorted elements. The exact tangent stiffness matrix is used. The optimal topology results are compared to the results obtained by using the classical Saint Venant-Kirchhoff constitutive law, and strong differences are found.

On the Debye-Hückel effect of electric screening

NASA Astrophysics Data System (ADS)

Campos, L. M. B. C.; Lau, F. J. P.

2014-07-01

The paper considers non-linear self-consistent electric potential equation (Sec. I), due to a cloud made of a single species of electric charges, satisfying a Boltzmann distribution law (Sec. II). Exact solutions are obtained in a simple logarithmic form, in three cases: (Sec. III) spherical radial symmetry; (Sec. IV) plane parallel symmetry; (Sec. V) a special case of azimuthal-cylindrical symmetry. All these solutions, and their transformations (Sec. VI), involve the Debye-Hückel radius; the latter was originally defined from a solution of the linearized self-consistent potential equation. Using an exact solution of the self-consistent potential equation, the distance at which the potential vanishes differs from the Debye-Hückel radius by a factor of √2 . The preceding (Secs. II-VI) simple logarithmic exact solutions of the self-consistent potential equations involve no arbitrary constants, and thus are special or singular integrals not the general integral. The general solution of the self-consistent potential equation is obtained in the plane parallel case (Sec. VII), and it involves two arbitrary constants that can be reduced to one via a translation (Sec. VIII). The plots of dimensionless potential (Figure 1), electric field (Figure 2), charge density (Figure 3), and total charge between ζ and infinity (Figure 4), versus distance normalized to Debye-Hückel radius ζ ≡ z/a, show that (Sec. IX) there is a continuum of solutions, ranging from a charge distribution concentrated inside the Debye-Hückel radius to one spread-out beyond it. The latter case leads to the limiting case of logarithmic potential, and stronger electric field; the former case, of very concentrated charge distribution, leads to a fratricide effect and weaker electric field.

Exact exchange plane-wave-pseudopotential calculations for slabs: Extending the width of the vacuum

NASA Astrophysics Data System (ADS)

Engel, Eberhard

2018-04-01

Standard plane-wave pseudopotential (PWPP) calculations for slabs such as graphene become extremely demanding, as soon as the exact exchange (EXX) of density functional theory is applied. Even if the Krieger-Li-Iafrate (KLI) approximation for the EXX potential is utilized, such EXX-PWPP calculations suffer from the fact that an accurate representation of the occupied states throughout the complete vacuum between the replicas of the slab is required. In this contribution, a robust and efficient extension scheme for the PWPP states is introduced, which ensures the correct exponential decay of the slab states in the vacuum for standard cutoff energies and therefore facilitates EXX-PWPP calculations for very wide vacua and rather thick slabs. Using this scheme, it is explicitly verified that the Slater component of the EXX/KLI potential decays as -1 /z over an extended region sufficiently far from the surface (assumed to be perpendicular to the z direction) and from the middle of the vacuum, thus reproducing the asymptotic behavior of the exact EXX potential of a single slab. The calculations also reveal that the orbital-shift component of the EXX/KLI potential is quite sizable in the asymptotic region. In spite of the long-range exchange potential, the replicas of the slab decouple rather quickly with increasing width of the vacuum. Relying on the identity of the work function with the Fermi energy obtained with a suitably normalized total potential, the present EXX/KLI calculations predict work functions for both graphene and the Si(111) surface which are substantially larger than the corresponding experimental data. Together with the size of the orbital-shift potential in the asymptotic region, the very large EXX/KLI work functions indicate a failure of the KLI approximation for nonmetallic slabs.

On the Debye–Hückel effect of electric screening

DOE Office of Scientific and Technical Information (OSTI.GOV)

Campos, L. M. B. C.; Lau, F. J. P.

2014-07-15

The paper considers non-linear self-consistent electric potential equation (Sec. I), due to a cloud made of a single species of electric charges, satisfying a Boltzmann distribution law (Sec. II). Exact solutions are obtained in a simple logarithmic form, in three cases: (Sec. III) spherical radial symmetry; (Sec. IV) plane parallel symmetry; (Sec. V) a special case of azimuthal-cylindrical symmetry. All these solutions, and their transformations (Sec. VI), involve the Debye-Hückel radius; the latter was originally defined from a solution of the linearized self-consistent potential equation. Using an exact solution of the self-consistent potential equation, the distance at which the potentialmore » vanishes differs from the Debye-Hückel radius by a factor of √(2). The preceding (Secs. II–VI) simple logarithmic exact solutions of the self-consistent potential equations involve no arbitrary constants, and thus are special or singular integrals not the general integral. The general solution of the self-consistent potential equation is obtained in the plane parallel case (Sec. VII), and it involves two arbitrary constants that can be reduced to one via a translation (Sec. VIII). The plots of dimensionless potential (Figure 1), electric field (Figure 2), charge density (Figure 3), and total charge between ζ and infinity (Figure 4), versus distance normalized to Debye-Hückel radius ζ ≡ z/a, show that (Sec. IX) there is a continuum of solutions, ranging from a charge distribution concentrated inside the Debye-Hückel radius to one spread-out beyond it. The latter case leads to the limiting case of logarithmic potential, and stronger electric field; the former case, of very concentrated charge distribution, leads to a fratricide effect and weaker electric field.« less

Exact solutions for sound radiation from a moving monopole above an impedance plane.

PubMed

Ochmann, Martin

2013-04-01

The acoustic field of a monopole source moving with constant velocity at constant height above an infinite locally reacting plane can be expressed in analytical form by combining the Lorentz transformation with the method of superimposing complex or real point sources. For a plane with masslike response, the solution in Lorentz space consists of a superposition of monopoles only and therefore, does not differ in principle from the solution for the corresponding stationary boundary value problem. However, by considering a frequency independent surface impedance, e.g., with pure absorbing behavior, the half-space Green's function is now comprised of not only a line of monopoles but also of dipoles. For certain field points at a special line g, this solution can be written explicitly by using an exponential integral. For arbitrary field points, the method of stationary phase leads to an asymptotic solution for the reflection coefficient which agrees with prior results from the literature.

Testing the Stability of 2-D Recursive QP, NSHP and General Digital Filters of Second Order

NASA Astrophysics Data System (ADS)

Rathinam, Ananthanarayanan; Ramesh, Rengaswamy; Reddy, P. Subbarami; Ramaswami, Ramaswamy

Several methods for testing stability of first quadrant quarter-plane two dimensional (2-D) recursive digital filters have been suggested in 1970's and 80's. Though Jury's row and column algorithms, row and column concatenation stability tests have been considered as highly efficient mapping methods. They still fall short of accuracy as they need infinite number of steps to conclude about the exact stability of the filters and also the computational time required is enormous. In this paper, we present procedurally very simple algebraic method requiring only two steps when applied to the second order 2-D quarter - plane filter. We extend the same method to the second order Non-Symmetric Half-plane (NSHP) filters. Enough examples are given for both these types of filters as well as some lower order general recursive 2-D digital filters. We applied our method to barely stable or barely unstable filter examples available in the literature and got the same decisions thus showing that our method is accurate enough.

The Aerodynamic Plane Table

NASA Technical Reports Server (NTRS)

Zahm, A F

1924-01-01

This report gives the description and the use of a specially designed aerodynamic plane table. For the accurate and expeditious geometrical measurement of models in an aerodynamic laboratory, and for miscellaneous truing operations, there is frequent need for a specially equipped plan table. For example, one may have to measure truly to 0.001 inch the offsets of an airfoil at many parts of its surface. Or the offsets of a strut, airship hull, or other carefully formed figure may require exact calipering. Again, a complete airplane model may have to be adjusted for correct incidence at all parts of its surfaces or verified in those parts for conformance to specifications. Such work, if but occasional, may be done on a planing or milling machine; but if frequent, justifies the provision of a special table. For this reason it was found desirable in 1918 to make the table described in this report and to equip it with such gauges and measures as the work should require.

Bond Dilution Effects on Bethe Lattice the Spin-1 Blume-Capel Model

NASA Astrophysics Data System (ADS)

Albayrak, Erhan

2017-09-01

The bond dilution effects are investigated for the spin-1 Blume-Capel model on the Bethe lattice by using the exact recursion relations. The bilinear interaction parameter is either turned on ferromagnetically with probability p or turned off with probability 1 - p between the nearest-neighbor spins. The thermal variations of the order-parameters are studied in detail to obtain the phase diagrams on the possible planes spanned by the temperature (T), probability (p) and crystal field (D) for the coordination numbers q = 3, 4, and 6. The lines of the second-order phase transitions, Tc-lines, combined with the first-order ones, Tt-lines, at the tricritical points (TCP) are always found for any p and q on the (T, D)-planes. It is also found that the model gives only Tc-lines, Tc-lines combined with the Tt-lines at the TCP’s and only Tt-lines with the consecutively decreasing values of D on the (T, p)-planes for all q.

Optimum threshold selection method of centroid computation for Gaussian spot

NASA Astrophysics Data System (ADS)

Li, Xuxu; Li, Xinyang; Wang, Caixia

2015-10-01

Centroid computation of Gaussian spot is often conducted to get the exact position of a target or to measure wave-front slopes in the fields of target tracking and wave-front sensing. Center of Gravity (CoG) is the most traditional method of centroid computation, known as its low algorithmic complexity. However both electronic noise from the detector and photonic noise from the environment reduces its accuracy. In order to improve the accuracy, thresholding is unavoidable before centroid computation, and optimum threshold need to be selected. In this paper, the model of Gaussian spot is established to analyze the performance of optimum threshold under different Signal-to-Noise Ratio (SNR) conditions. Besides, two optimum threshold selection methods are introduced: TmCoG (using m % of the maximum intensity of spot as threshold), and TkCoG ( usingμn +κσ n as the threshold), μn and σn are the mean value and deviation of back noise. Firstly, their impact on the detection error under various SNR conditions is simulated respectively to find the way to decide the value of k or m. Then, a comparison between them is made. According to the simulation result, TmCoG is superior over TkCoG for the accuracy of selected threshold, and detection error is also lower.

Exchange-correlation energies of atoms from efficient density functionals: influence of the electron density

DOE PAGES

Tao, Jianmin; Ye, Lin -Hui; Duan, Yuhua

2017-11-20

The primary goal of Kohn–Sham density functional theory is to evaluate the exchange-correlation contribution to electronic properties. However, the accuracy of a density functional can be affected by the electron density. Here we apply the nonempirical Tao–Mo (TM) semilocal functional to study the influence of the electron density on the exchange and correlation energies of atoms and ions, and compare the results with the commonly used nonempirical semilocal functionals local spin-density approximation (LSDA), Perdew–Burke–Ernzerhof (PBE), Tao–Perdew–Staroverov–Scuseria (TPSS), and hybrid functional PBE0. We find that the spin-restricted Hartree–Fock density yields the exchange and correlation energies in good agreement with the Optimizedmore » Effective Potential method, particularly for spherical atoms and ions. However, the errors of these semilocal and hybrid functionals become larger for self-consistent densities. We further find that the quality of the electron density have greater effect on the exchange-correlation energies of kinetic energy density-dependent meta-GGA functionals TPSS and TM than on those of the LSDA and GGA, and therefore, should have greater influence on the performance of meta-GGA functionals. Lastly, we show that the influence of the density quality on PBE0 is slightly reduced, compared to that of PBE, due to the exact mixing.« less

Exchange-correlation energies of atoms from efficient density functionals: influence of the electron density

NASA Astrophysics Data System (ADS)

Tao, Jianmin; Ye, Lin-Hui; Duan, Yuhua

2017-12-01

The primary goal of Kohn-Sham density functional theory is to evaluate the exchange-correlation contribution to electronic properties. However, the accuracy of a density functional can be affected by the electron density. Here we apply the nonempirical Tao-Mo (TM) semilocal functional to study the influence of the electron density on the exchange and correlation energies of atoms and ions, and compare the results with the commonly used nonempirical semilocal functionals local spin-density approximation (LSDA), Perdew-Burke-Ernzerhof (PBE), Tao-Perdew-Staroverov-Scuseria (TPSS), and hybrid functional PBE0. We find that the spin-restricted Hartree-Fock density yields the exchange and correlation energies in good agreement with the Optimized Effective Potential method, particularly for spherical atoms and ions. However, the errors of these semilocal and hybrid functionals become larger for self-consistent densities. We further find that the quality of the electron density have greater effect on the exchange-correlation energies of kinetic energy density-dependent meta-GGA functionals TPSS and TM than on those of the LSDA and GGA, and therefore, should have greater influence on the performance of meta-GGA functionals. Finally, we show that the influence of the density quality on PBE0 is slightly reduced, compared to that of PBE, due to the exact mixing.

Exchange-correlation energies of atoms from efficient density functionals: influence of the electron density

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tao, Jianmin; Ye, Lin -Hui; Duan, Yuhua

The primary goal of Kohn–Sham density functional theory is to evaluate the exchange-correlation contribution to electronic properties. However, the accuracy of a density functional can be affected by the electron density. Here we apply the nonempirical Tao–Mo (TM) semilocal functional to study the influence of the electron density on the exchange and correlation energies of atoms and ions, and compare the results with the commonly used nonempirical semilocal functionals local spin-density approximation (LSDA), Perdew–Burke–Ernzerhof (PBE), Tao–Perdew–Staroverov–Scuseria (TPSS), and hybrid functional PBE0. We find that the spin-restricted Hartree–Fock density yields the exchange and correlation energies in good agreement with the Optimizedmore » Effective Potential method, particularly for spherical atoms and ions. However, the errors of these semilocal and hybrid functionals become larger for self-consistent densities. We further find that the quality of the electron density have greater effect on the exchange-correlation energies of kinetic energy density-dependent meta-GGA functionals TPSS and TM than on those of the LSDA and GGA, and therefore, should have greater influence on the performance of meta-GGA functionals. Lastly, we show that the influence of the density quality on PBE0 is slightly reduced, compared to that of PBE, due to the exact mixing.« less

Motivation and treatment engagement intervention trial (MotivaTe-IT): the effects of motivation feedback to clinicians on treatment engagement in patients with severe mental illness.

PubMed

Jochems, Eline C; Mulder, Cornelis L; van Dam, Arno; Duivenvoorden, Hugo J; Scheffer, Sylvia C M; van der Spek, Willem; van der Feltz-Cornelis, Christina M

2012-11-24

Treatment disengagement and non-completion poses a major problem for the successful treatment of patients with severe mental illness. Motivation for treatment has long been proposed as a major determinant of treatment engagement, but exact mechanisms remain unclear. This current study serves three purposes: 1) to determine whether a feedback intervention based on the patients' motivation for treatment is effective at improving treatment engagement (TE) of severe mentally ill patients in outpatient psychiatric treatment, 2) to gather insight into motivational processes and possible mechanisms regarding treatment motivation (TM) and TE in this patient population and 3) to determine which of three theories of motivation is most plausible for the dynamics of TM and TE in this population. The Motivation and Treatment Engagement Intervention Trial (MotivaTe-IT) is a multi-center cluster randomized trial investigating the effectiveness of feedback generated by clinicians regarding their patients' treatment motivation upon the patients' TE. The primary outcome is the patients' TE. Secondary outcomes are TM, psychosocial functioning and quality of life. Patients whose clinicians generate monthly motivation feedback (additional to treatment as usual) will be compared to patients who receive treatment as usual. An estimated 350 patients, aged 18 to 65 years, with psychotic disorders and/or severe personality disorders will be recruited from outpatient community mental health care. The randomization will be performed by a computerized randomization program, with an allocation ratio of 1:1 (team vs. team or clinician vs. clinician) and patients, but not clinicians, will be blind to treatment allocation at baseline assessment. Due to the nature of the trial, follow-up assessment can not be blinded. The current study can provide important insights regarding motivational processes and the way in which motivation influences the treatment engagement and clinical outcomes. The identification of possible mechanisms through which changes in the outcomes occur, offers a tool for the development of more effective future interventions to improve TM and TE. Current Controlled Trials NTR2968.

Motivation and treatment engagement intervention trial (MotivaTe-IT): the effects of motivation feedback to clinicians on treatment engagement in patients with severe mental illness

PubMed Central

2012-01-01

Background Treatment disengagement and non-completion poses a major problem for the successful treatment of patients with severe mental illness. Motivation for treatment has long been proposed as a major determinant of treatment engagement, but exact mechanisms remain unclear. This current study serves three purposes: 1) to determine whether a feedback intervention based on the patients’ motivation for treatment is effective at improving treatment engagement (TE) of severe mentally ill patients in outpatient psychiatric treatment, 2) to gather insight into motivational processes and possible mechanisms regarding treatment motivation (TM) and TE in this patient population and 3) to determine which of three theories of motivation is most plausible for the dynamics of TM and TE in this population. Methods/design The Motivation and Treatment Engagement Intervention Trial (MotivaTe-IT) is a multi-center cluster randomized trial investigating the effectiveness of feedback generated by clinicians regarding their patients’ treatment motivation upon the patients’ TE. The primary outcome is the patients’ TE. Secondary outcomes are TM, psychosocial functioning and quality of life. Patients whose clinicians generate monthly motivation feedback (additional to treatment as usual) will be compared to patients who receive treatment as usual. An estimated 350 patients, aged 18 to 65 years, with psychotic disorders and/or severe personality disorders will be recruited from outpatient community mental health care. The randomization will be performed by a computerized randomization program, with an allocation ratio of 1:1 (team vs. team or clinician vs. clinician) and patients, but not clinicians, will be blind to treatment allocation at baseline assessment. Due to the nature of the trial, follow-up assessment can not be blinded. Discussion The current study can provide important insights regarding motivational processes and the way in which motivation influences the treatment engagement and clinical outcomes. The identification of possible mechanisms through which changes in the outcomes occur, offers a tool for the development of more effective future interventions to improve TM and TE. Trial registration Current Controlled Trials NTR2968 PMID:23176560

Processing and characterization of phase boundaries in ceramic and metallic materials

NASA Astrophysics Data System (ADS)

Zeng, Liang

The goal of this dissertation work was to explore and describe advanced characterization of novel materials processing. These characterizations were carried out using scanning and transmission electron microscopy (SEM and TEM), and X-ray diffraction techniques. The materials studied included ceramics and metallic materials. The first part of this dissertation focuses on the processing, and the resulting interfacial microstructure of ceramics joined using spin-on interlayers. SEM, TEM, and indentation tests were used to investigate the interfacial microstructural and mechanical property evolution of polycrystalline zirconia bonded to glass ceramic MaCor(TM), and polycrystalline alumina to single crystal alumina. Interlayer assisted specimens were joined using a thin amorphous silica interlayer. This interlayer was produced by spin coating an organic based silica bond material precursor and curing at 200°C, followed by joining in a microwave cavity or conventional electric furnace. Experimental results indicate that in the joining of the zirconia and MaCor(TM) no significant interfacial microstructural and mechanical property differences developed between materials joined either with or without interlayers, due to the glassy nature of MaCor(TM). The bond interface was non-planar, as a result of the strong wetting of MaCor(TM) and silica and dissolution of the zirconia. However, without the aid of a silica interlayer, sapphire and 98% polycrystalline alumina failed to join under the experimental conditions under this study. A variety of interfacial morphologies have been observed, including amorphous regions, fine crystalline alumina, and intimate contact between the sapphire and polycrystalline alumina. In addition, the evolution of the joining process from the initial sputter-cure to the final joining state and joining mechanisms were characterized. The second part of this dissertation focused on the effects of working and heat treatment on microstructure, texture, phase boundary movement, and mechanical property evolution in Ti-6Al-4V wire. The as-received wire consisted of equilibrium a and metastable beta phases and had a moderately strong fiber texture with prism plane normals aligned with the wire axis. The wire was worked by extrusion, solution heat-treatment and water quenching, and aging. The extrusion process strengthened the as-received texture. After solutionization and quenching, microstrucual observations showed the presence of many needlelike martensitic platelets in the prior beta phase regions. Texture analysis revealed that a secondary fiber with basal plane normals aligned with the wire axis emerged at the expense of the initial texture, indicating that highly preferred phase boundary motion (variant selection) occurred during the beta → alpha transformation. The strength of the variant selection consistently increased with solutionization temperature and time. In addition, the effects of dislocation type and density on variant selections were further investigated. This implies that strategic prior deformation and heat treatment can be exploited to design the resulting texture and microstructure and consequently optimize the properties of titanium products.

Rotation of intramedullary alignment rods affects distal femoral cutting plane in total knee arthroplasty.

PubMed

Maderbacher, Günther; Matussek, Jan; Keshmiri, Armin; Greimel, Felix; Baier, Clemens; Grifka, Joachim; Maderbacher, Hermann

2018-02-17

Intramedullary rods are widely used to align the distal femoral cut in total knee arthroplasty. We hypothesised that both coronal (varus/valgus) and sagittal (extension/flexion) cutting plane are affected by rotational changes of intramedullary femoral alignment guides. Distal femoral cuts using intramedullary alignment rods were simulated by means of a computer-aided engineering software in 4°, 6°, 8°, 10°, and 12° of valgus in relation to the femoral anatomical axis and 4° extension, neutral, as well as 4°, 8°, and 12° of flexion in relation to the femoral mechanical axis. This reflects the different angles between anatomical and mechanical axis in coronal and sagittal planes. To assess the influence of rotation of the alignment guide on the effective distal femoral cutting plane, all combinations were simulated with the rod gradually aligned from 40° of external to 40° of internal rotation. Rotational changes of the distal femoral alignment guides affect both the coronal and sagittal cutting planes. When alignment rods are intruded neutrally with regards to sagittal alignment, external rotation causes flexion, while internal rotation causes extension of the sagittal cutting plane. Simultaneously the coronal effect (valgus) decreases resulting in an increased varus of the cutting plane. However, when alignment rods are intruded in extension or flexion partly contradictory effects are observed. Generally the effect increases with the degree of valgus preset, rotation and flexion. As incorrect rotation of intramedullary alignment guides for distal femoral cuts causes significant cutting errors, exact rotational alignment is crucial. Coronal cutting errors in the distal femoral plane might result in overall leg malalignment, asymmetric extension gaps and subsequent sagittal cutting errors.

Dolan Grady relations and noncommutative quasi-exactly solvable systems

NASA Astrophysics Data System (ADS)

Klishevich, Sergey M.; Plyushchay, Mikhail S.

2003-11-01

We investigate a U(1) gauge invariant quantum mechanical system on a 2D noncommutative space with coordinates generating a generalized deformed oscillator algebra. The Hamiltonian is taken as a quadratic form in gauge covariant derivatives obeying the nonlinear Dolan-Grady relations. This restricts the structure function of the deformed oscillator algebra to a quadratic polynomial. The cases when the coordinates form the {\\mathfrak{su}}(2) and {\\mathfrak{sl}}(2,{\\bb {R}}) algebras are investigated in detail. Reducing the Hamiltonian to 1D finite-difference quasi-exactly solvable operators, we demonstrate partial algebraization of the spectrum of the corresponding systems on the fuzzy sphere and noncommutative hyperbolic plane. A completely covariant method based on the notion of intrinsic algebra is proposed to deal with the spectral problem of such systems.

Performance of cellular frequency-hopped spread-spectrum radio networks

NASA Astrophysics Data System (ADS)

Gluck, Jeffrey W.; Geraniotis, Evaggelos

1989-10-01

Multiple access interference is characterized for cellular mobile networks, in which users are assumed to be Poisson-distributed in the plane and employ frequency-hopped spread-spectrum signaling with transmitter-oriented assignment of frequency-hopping patterns. Exact expressions for the bit error probabilities are derived for binary coherently demodulated systems without coding. Approximations for the packet error probability are derived for coherent and noncoherent systems and these approximations are applied when forward-error-control coding is employed. In all cases, the effects of varying interference power are accurately taken into account according to some propagation law. Numerical results are given in terms of bit error probability for the exact case and throughput for the approximate analyses. Comparisons are made with previously derived bounds and it is shown that these tend to be very pessimistic.

An evaluation of relation between the relative parallelism of occlusal plane to ala-tragal line and variation in the angulation of Po-Na-ANS angle in dentulous subjects: A cephalometric study

PubMed Central

Shetty, Sanath; Shenoy, K. Kamalakanth; Ninan, Justin; Mahaseth, Pranay

2015-01-01

Aims: The aim was to evaluate if any correlation exists between variation in angulation of Po-Na-ANS angle and relative parallelism of the occlusal plane to the different tragal levels of the ear in dentulous subjects. Methodology: A total of 200 subjects were selected for the study. A custom made occlusal plane analyzer was used to determine the posterior point of the ala-tragal line. The lateral cephalogram was shot for each of the subjects. The points Porion, Nasion, and Anterior Nasal Spine were located and the angle formed between these points was measured. Statistical Analysis Used: Fischer's exact test was used to find the correlation between Po-Na-ANS angle and relative parallelism of the occlusal plane to the ala-tragal line at different tragal levels. Results: Statistical analysis showed no significant correlation between Po-Na-ANS angle and relative parallelism of an occlusal plane at different tragal levels, and an inferior point on the tragus was the most common. Conclusion: Irrespective of variations in the Po-Na-ANS angle, no correlation exists between the variation in the angulations of Po-Na-ANS angle and the relative parallelism of occlusal plane to the ala-tragal line at different tragal levels. Furthermore, in a large number of subjects (54%), the occlusal plane was found parallel to a line joining the inferior border of the ala of the nose and the inferior part of the tragus. PMID:26929506

C-Cr segregation at grain boundary before the carbide nucleation in Alloy 690

DOE Office of Scientific and Technical Information (OSTI.GOV)

Li Hui, E-mail: huili@shu.edu.cn; Laboratory for Microstructures, Shanghai University, Shanghai, 200444; Xia Shuang

2012-04-15

The grain boundary segregation in Alloy 690 was investigated by atom probe tomography. B, C and Si segregated at the grain boundary. The high concentration regions for each segregation element form a set of straight arrays that are parallel to each other in the grain boundary plane. The concentration fluctuation has a periodicity of about 7 nm in the grain boundary plane. Before the Cr{sub 23}C{sub 6} nucleation at grain boundaries, the C-Cr co-segregate on one side of the grain boundaries while not the exact grain boundary core regions have been detected. The reasons why grain boundary carbides have coherentmore » orientation relationship only with one side of nearby grain which grain boundary is located at high index crystal plane were discussed. - Highlights: Black-Right-Pointing-Pointer Grain boundary segregation in Alloy 690 was investigated by atom probe tomography. Black-Right-Pointing-Pointer B, C and Si segregate at the grain boundary. Black-Right-Pointing-Pointer Concentration of segregated atoms periodicity fluctuated in the grain boundary plane. Black-Right-Pointing-Pointer C and Cr co-segregate on one side of the grain boundary before carbide nucleation.« less

Two charges on plane in a magnetic field I. “Quasi-equal” charges and neutral quantum system at rest cases

DOE Office of Scientific and Technical Information (OSTI.GOV)

Escobar-Ruiz, M.A., E-mail: mauricio.escobar@nucleares.unam.mx; Turbiner, A.V., E-mail: turbiner@nucleares.unam.mx

Low-lying bound states for the problem of two Coulomb charges of finite masses on a plane subject to a constant magnetic field B perpendicular to the plane are considered. Major emphasis is given to two systems: two charges with the equal charge-to-mass ratio (quasi-equal charges) and neutral systems with concrete results for the hydrogen atom and two electrons (quantum dot). It is shown that for these two cases, when a neutral system is at rest (the center-of-mass momentum is zero), some outstanding properties occur: in double polar coordinates in CMS (R,ϕ) and relative (ρ,φ) coordinate systems (i) the eigenfunctions aremore » factorizable, all factors except for ρ-dependent are found analytically, they have definite relative angular momentum, (ii) dynamics in ρ-direction is the same for both systems being described by a funnel-type potential; (iii) at some discrete values of dimensionless magnetic fields b≤1 the system becomes quasi-exactly-solvable and a finite number of eigenfunctions in ρ are polynomials. The variational method is employed. Trial functions are based on combining for the phase of a wavefunction (a) the WKB expansion at large distances, (b) the perturbation theory at small distances (c) with a form of the known analytically (quasi-exactly-solvable) eigenfunctions. Such a form of trial function appears as a compact uniform approximation for lowest eigenfunctions. For the lowest states with relative magnetic quantum numbers s=0,1,2 this approximation gives not less than 7 s.d., 8 s.d., 9 s.d., respectively, for the total energy E(B) for magnetic fields 0.049a.u.« less

Applying translabial ultrasound to detect synthetic slings-You can do it too! A comparison of urology trainees to an attending radiologist.

PubMed

Shen, Jim K; Faaborg, Daniel; Rouse, Glenn; Kelly, Isaac; Li, Roger; Alsyouf, Muhannad; Myklak, Kristene; Distelberg, Brian; Staack, Andrea

2017-09-01

Translabial ultrasound (TUS) is a useful tool for identifying and assessing synthetic slings. This study evaluates the ability of urology trainees to learn basic pelvic anatomy and sling assessment on TUS. Eight urology trainees (six residents and two medical students) received a lecture reviewing basic anatomy and sling assessment on TUS followed by review of two training cases. Next, they underwent a 126-question examination assessing their ability to identify anatomic planes and structures in those planes, identify the presence of slings, and assess the location and intactness of a sling. The correct response rate was compared to that of an attending radiologist experienced in reading TUS. Non-parametric tests (Fisher's exact, chi-squared tests, and Yates correction) were used for statistical analysis, with P < 0.05 considered significant. 847/1008 (84.0%) of questions were answered correctly by eight trainees compared to 119/126 (94.4%) by the radiologist (P = 0.001). The trainees' correct response rates and Fisher's exact test P values associated with the difference in correct answers between radiologist and trainee were as follows: identification of anatomic plane (94.4%; P = 0.599), identification of structure in sagittal view (80.6%; P = 0.201), identification of structure in transverse view (88.2%; P = 0.696), presence of synthetic sling (95.8%; P = 1.000), location of sling along the urethra in (71.5%; P = 0.403), intactness of sling (82.6%; P = 0.311), and laterality of sling disruption (75.0%; P = 0.076). Urology trainees can quickly learn to identify anatomic landmarks and assess slings on TUS with reasonable proficiency compared to an experienced attending radiologist. © 2017 Wiley Periodicals, Inc.

Cumulant generating function formula of heat transfer in ballistic systems with lead-lead coupling and general nonlinear systems

NASA Astrophysics Data System (ADS)

Li, Huanan

2013-03-01

Based on a two-time observation protocol, we consider heat transfer in a given time interval tM in a lead-junction-lead system taking coupling between the leads into account. In view of the two-time observation, consistency conditions are carefully verified in our specific family of quantum histories. Furthermore, its implication is briefly explored. Then using the nonequilibrium Green's function method, we obtain an exact formula for the cumulant generating function for heat transfer between the two leads, valid in both transient and steady-state regimes. Also, a compact formula for the cumulant generating function in the long-time limit is derived, for which the Gallavotti-Cohen fluctuation symmetry is explicitly verified. In addition, we briefly discuss Di Ventra's repartitioning trick regarding whether the repartitioning procedure of the total Hamiltonian affects the nonequilibrium steady-state current fluctuation. All kinds of properties of nonequilibrium current fluctuations, such as the fluctuation theorem in different time regimes, could be readily given according to these exact formulas. Finally a practical formalism dealing with cumulants of heat transfer across general nonlinear quantum systems is established based on field theoretical/algebraic method.

Vector scattering analysis of TPF coronagraph pupil masks

NASA Astrophysics Data System (ADS)

Ceperley, Daniel P.; Neureuther, Andrew R.; Lieber, Michael D.; Kasdin, N. Jeremy; Shih, Ta-Ming

2004-10-01

Rigorous finite-difference time-domain electromagnetic simulation is used to simulate the scattering from proto-typical pupil mask cross-section geometries and to quantify the differences from the normally assumed ideal on-off behavior. Shaped pupil plane masks are a promising technology for the TPF coronagraph mission. However the stringent requirements placed on the optics require that the detailed behavior of the edge-effects of these masks be examined carefully. End-to-end optical system simulation is essential and an important aspect is the polarization and cross-section dependent edge-effects which are the subject of this paper. Pupil plane masks are similar in many respects to photomasks used in the integrated circuit industry. Simulation capabilities such as the FDTD simulator, TEMPEST, developed for analyzing polarization and intensity imbalance effects in nonplanar phase-shifting photomasks, offer a leg-up in analyzing coronagraph masks. However, the accuracy in magnitude and phase required for modeling a chronograph system is extremely demanding and previously inconsequential errors may be of the same order of magnitude as the physical phenomena under study. In this paper, effects of thick masks, finite conductivity metals, and various cross-section geometries on the transmission of pupil-plane masks are illustrated. Undercutting the edge shape of Cr masks improves the effective opening width to within λ/5 of the actual opening but TE and TM polarizations require opposite compensations. The deviation from ideal is examined at the reference plane of the mask opening. Numerical errors in TEMPEST, such as numerical dispersion, perfectly matched layer reflections, and source haze are also discussed along with techniques for mitigating their impacts.

Second order gradiometer and dc SQUID integrated on a planar substrate

NASA Astrophysics Data System (ADS)

van Nieuwenhuyzen, G. J.; de Waal, V. J.

1985-02-01

An integrated system of a thin-film niobium dc superconducting quantum interference device (SQUID) and a second order gradiometer on a planar substrate is described. The system consists of a dc SQUID with eight loops in parallel, each sensitive to the second derivative ∂2Bz/∂x2 of the magnetic field. The calculated SQUID inductance is 1.3 nH. With an overall size of 16×16.5 mm2 a sensitivity of 1.5×10-9 Tm-2 Hz-1/2 is obtained. The measured transfer function for uniform fields perpendicular to the plane of the gradiometer is 2.1×10-7 T Φ-10.

FIBER AND INTEGRATED OPTICS: Investigation of a fiber-optic polarizer with a metal film and a dielectric buffer layer

NASA Astrophysics Data System (ADS)

Gelikonov, V. M.; Gusovskiĭ, D. D.; Konoplev, Yu N.; Leonov, V. I.; Mamaev, Yu A.; Turkin, A. A.

1990-01-01

A model of a plane-layer waveguide is used in a theoretical analysis of the attenuation coefficients of the TM0 and TE0 waves in a fiber-optic polarizer with a metal film and two dielectric buffer layers, one of which is the residual part of the fiber cladding. A report is given of the construction and experimental investigation of polarizers with a buffer layer of magnesium fluoride and an aluminum film operating at wavelengths of 0.63 and 0.81 μm and characterized by extinction coefficients of at least 53 and 46 dB, respectively, and by losses not exceeding 0.5 dB.

Design of an optomechanical filter based on solid/solid phoxonic crystals

NASA Astrophysics Data System (ADS)

Moradi, Pedram; Bahrami, Ali

2018-03-01

We simulate a phoxonic crystal which shows complete phononic and TM-polarized photonic bandgaps. The constituent materials are tungsten and polymethyl methacrylate, and we obtained these bandgaps with a filling factor of only 28%, which is very compatible with the fabrication method. A cavity was then defined that selects narrow passbands of optical and elastic waves. In order to maximize the quality factor, a defect rod is added in the output waveguide. The final structure filters an optical wavelength of 840 nm (with corresponding frequency of 357 THz) and an elastic frequency of 3.6703 GHz. Simulations are done by using finite element, plane wave expansion, and finite difference time domain methods.

Dependency of Shear Strength on Test Rate in SiC/BSAS Ceramic Matrix Composite at Elevated Temperature

NASA Technical Reports Server (NTRS)

Choi, Sung R.; Bansal, Narottam P.; Gyekenyesi, John P.

2003-01-01

Both interlaminar and in-plane shear strengths of a unidirectional Hi-Nicalon(TM) fiber-reinforced barium strontium aluminosilicate (SiC/BSAS) composite were determined at 1100 C in air as a function of test rate using double notch shear test specimens. The composite exhibited a significant effect of test rate on shear strength, regardless of orientation which was either in interlaminar or in in-plane direction, resulting in an appreciable shear-strength degradation of about 50 percent as test rate decreased from 3.3 10(exp -1) mm/s to 3.3 10(exp -5) mm/s. The rate dependency of composite's shear strength was very similar to that of ultimate tensile strength at 1100 C observed in a similar composite (2-D SiC/BSAS) in which tensile strength decreased by about 60 percent when test rate varied from the highest (5 MPa/s) to the lowest (0.005 MPa/s). A phenomenological, power-law slow crack growth formulation was proposed and formulated to account for the rate dependency of shear strength of the composite.

Breakthrough in orbit determination of a binary. - In expectation of astrometric observations with high precision such as VERA and JASMINE -

NASA Astrophysics Data System (ADS)

Asada, Hideki

2006-11-01

There exists a very classical inverse problem regarding orbit determination of a binary system: "when an orbital plane of two bodies is inclined with respect to the line of sight, observables are their positions projected onto a celestial sphere. How do we determine the orbital elements from observations?" A "complete exact solution" has been found. It is reviewed with some related topics.

Modeling of structural uncertainties in Reynolds-averaged Navier-Stokes closures

NASA Astrophysics Data System (ADS)

Emory, Michael; Larsson, Johan; Iaccarino, Gianluca

2013-11-01

Estimation of the uncertainty in numerical predictions by Reynolds-averaged Navier-Stokes closures is a vital step in building confidence in such predictions. An approach to model-form uncertainty quantification that does not assume the eddy-viscosity hypothesis to be exact is proposed. The methodology for estimation of uncertainty is demonstrated for plane channel flow, for a duct with secondary flows, and for the shock/boundary-layer interaction over a transonic bump.

Electronic transitions in quantum dots and rings induced by inhomogeneous off-centered light beams.

PubMed

Quinteiro, G F; Lucero, A O; Tamborenea, P I

2010-12-22

We theoretically investigate the effect of inhomogeneous light beams with (twisted light) and without (plane-wave light) orbital angular momentum on semiconductor-based nanostructures, when the symmetry axes of the beam and the nanostructure are displaced parallel to each other. Exact analytical results are obtained by expanding the off-centered light field in terms of the appropriate light modes centered around the nanostructure. We demonstrate how electronic transitions involving the transfer of different amounts of orbital angular momentum are switched on and off as a function of the separation between the axes of the beam and the system. In particular, we show that even off-centered plane-wave beams induce transitions such that the angular momenta of the initial and final states are different.

Finite deformation of incompressible fiber-reinforced elastomers: A computational micromechanics approach

NASA Astrophysics Data System (ADS)

Moraleda, Joaquín; Segurado, Javier; LLorca, Javier

2009-09-01

The in-plane finite deformation of incompressible fiber-reinforced elastomers was studied using computational micromechanics. Composite microstructure was made up of a random and homogeneous dispersion of aligned rigid fibers within a hyperelastic matrix. Different matrices (Neo-Hookean and Gent), fibers (monodisperse or polydisperse, circular or elliptical section) and reinforcement volume fractions (10-40%) were analyzed through the finite element simulation of a representative volume element of the microstructure. A successive remeshing strategy was employed when necessary to reach the large deformation regime in which the evolution of the microstructure influences the effective properties. The simulations provided for the first time "quasi-exact" results of the in-plane finite deformation for this class of composites, which were used to assess the accuracy of the available homogenization estimates for incompressible hyperelastic composites.

Bianchi class B spacetimes with electromagnetic fields

NASA Astrophysics Data System (ADS)

Yamamoto, Kei

2012-02-01

We carry out a thorough analysis on a class of cosmological space-times which admit three spacelike Killing vectors of Bianchi class B and contain electromagnetic fields. Using dynamical system analysis, we show that a family of electro-vacuum plane-wave solutions of the Einstein-Maxwell equations is the stable attractor for expanding universes. Phase dynamics are investigated in detail for particular symmetric models. We integrate the system exactly for some special cases to confirm the qualitative features. Some of the obtained solutions have not been presented previously to the best of our knowledge. Finally, based on those analyses, we discuss the relation between those homogeneous models and perturbations of open Friedmann-Lemaitre-Robertson-Walker universes. We argue that the electro-vacuum plane-wave modes correspond to a certain long-wavelength limit of electromagnetic perturbations.

Exact Solutions for Stokes' Flow of a Non-Newtonian Nanofluid Model: A Lie Similarity Approach

NASA Astrophysics Data System (ADS)

Aziz, Taha; Aziz, A.; Khalique, C. M.

2016-07-01

The fully developed time-dependent flow of an incompressible, thermodynamically compatible non-Newtonian third-grade nanofluid is investigated. The classical Stokes model is considered in which the flow is generated due to the motion of the plate in its own plane with an impulsive velocity. The Lie symmetry approach is utilised to convert the governing nonlinear partial differential equation into different linear and nonlinear ordinary differential equations. The reduced ordinary differential equations are then solved by using the compatibility and generalised group method. Exact solutions for the model equation are deduced in the form of closed-form exponential functions which are not available in the literature before. In addition, we also derived the conservation laws associated with the governing model. Finally, the physical features of the pertinent parameters are discussed in detail through several graphs.

Laser radiation in active amplifying media treated as a transport problem - Transfer equation derived and exactly solved

NASA Astrophysics Data System (ADS)

Gupta, S. R. D.; Gupta, Santanu D.

1991-10-01

The flow of laser radiation in a plane-parallel cylindrical slab of active amplifying medium with axial symmetry is treated as a problem in radiative transfer. The appropriate one-dimensional transfer equation describing the transfer of laser radiation has been derived by an appeal to Einstein's A, B coefficients (describing the processes of stimulated line absorption, spontaneous line emission, and stimulated line emission sustained by population inversion in the medium) and considering the 'rate equations' to completely establish the rational of the transfer equation obtained. The equation is then exactly solved and the angular distribution of the emergent laser beam intensity is obtained; its numerically computed values are given in tables and plotted in graphs showing the nature of peaks of the emerging laser beam intensity about the axis of the laser cylinder.

An exact noniterative linear method for locating sources based on measuring receiver arrival times.

PubMed

Militello, C; Buenafuente, S R

2007-06-01

In this paper an exact, linear solution to the source localization problem based on the time of arrival at the receivers is presented. The method is unique in that the source's position can be obtained by solving a system of linear equations, three for a plane and four for a volume. This simplification means adding an additional receiver to the minimum mathematically required (3+1 in two dimensions and 4+1 in three dimensions). The equations are easily worked out for any receiver configuration and their geometrical interpretation is straightforward. Unlike other methods, the system of reference used to describe the receivers' positions is completely arbitrary. The relationship between this method and previously published ones is discussed, showing how the present, more general, method overcomes nonlinearity and unknown dependency issues.

A class of reduced-order models in the theory of waves and stability.

PubMed

Chapman, C J; Sorokin, S V

2016-02-01

This paper presents a class of approximations to a type of wave field for which the dispersion relation is transcendental. The approximations have two defining characteristics: (i) they give the field shape exactly when the frequency and wavenumber lie on a grid of points in the (frequency, wavenumber) plane and (ii) the approximate dispersion relations are polynomials that pass exactly through points on this grid. Thus, the method is interpolatory in nature, but the interpolation takes place in (frequency, wavenumber) space, rather than in physical space. Full details are presented for a non-trivial example, that of antisymmetric elastic waves in a layer. The method is related to partial fraction expansions and barycentric representations of functions. An asymptotic analysis is presented, involving Stirling's approximation to the psi function, and a logarithmic correction to the polynomial dispersion relation.

A 3D photographic capsule endoscope system with full field of view

NASA Astrophysics Data System (ADS)

Ou-Yang, Mang; Jeng, Wei-De; Lai, Chien-Cheng; Kung, Yi-Chinn; Tao, Kuan-Heng

2013-09-01

Current capsule endoscope uses one camera to capture the surface image in the intestine. It can only observe the abnormal point, but cannot know the exact information of this abnormal point. Using two cameras can generate 3D images, but the visual plane changes while capsule endoscope rotates. It causes that two cameras can't capture the images information completely. To solve this question, this research provides a new kind of capsule endoscope to capture 3D images, which is 'A 3D photographic capsule endoscope system'. The system uses three cameras to capture images in real time. The advantage is increasing the viewing range up to 2.99 times respect to the two camera system. The system can accompany 3D monitor provides the exact information of symptom points, helping doctors diagnose the disease.

Finite-surface method for the Maxwell equations with corner singularities

NASA Technical Reports Server (NTRS)

Vinokur, Marcel; Yarrow, Maurice

1994-01-01

The finite-surface method for the two-dimensional Maxwell equations in generalized coordinates is extended to treat perfect conductor boundaries with sharp corners. Known singular forms of the grid and the electromagnetic fields in the neighborhood of each corner are used to obtain accurate approximations to the surface and line integrals appearing in the method. Numerical results are presented for a harmonic plane wave incident on a finite flat plate. Comparisons with exact solutions show good agreement.

USSR and Eastern Europe Scientific Abstracts- Physics - Number 45

DTIC Science & Technology

1978-10-02

compound, a function of the angle between the electrical vector of the ’ light wave and the optical c-axis of the crystal. Heterodiodes have first...of naturally radioactive U, Th and K in a 1-liter sample. USSR A VECTOR MESON IN A QUANTUM ELECTROMAGNETIC FIELD Moscow TEORETICHESKAYA I...arbitrary spin in a classical plane electromagnetic field are used to find the exact wave function of a vector meson in the quantum field of a linearly

A connection between the maximum displacements of rogue waves and the dynamics of poles in the complex plane.

PubMed

Liu, T Y; Chiu, T L; Clarkson, P A; Chow, K W

2017-09-01

Rogue waves of evolution systems are displacements which are localized in both space and time. The locations of the points of maximum displacements of the wave profiles may correlate with the trajectories of the poles of the exact solutions from the perspective of complex variables through analytic continuation. More precisely, the location of the maximum height of the rogue wave in laboratory coordinates (real space and time) is conjectured to be equal to the real part of the pole of the exact solution, if the spatial coordinate is allowed to be complex. This feature can be verified readily for the Peregrine breather (lowest order rogue wave) of the nonlinear Schrödinger equation. This connection is further demonstrated numerically here for more complicated scenarios, namely the second order rogue wave of the Boussinesq equation (for bidirectional long waves in shallow water), an asymmetric second order rogue wave for the nonlinear Schrödinger equation (as evolution system for slowly varying wave packets), and a symmetric second order rogue wave of coupled Schrödinger systems. Furthermore, the maximum displacements in physical space occur at a time instant where the trajectories of the poles in the complex plane reverse directions. This property is conjectured to hold for many other systems, and will help to determine the maximum amplitudes of rogue waves.

A connection between the maximum displacements of rogue waves and the dynamics of poles in the complex plane

NASA Astrophysics Data System (ADS)

Liu, T. Y.; Chiu, T. L.; Clarkson, P. A.; Chow, K. W.

2017-09-01

Rogue waves of evolution systems are displacements which are localized in both space and time. The locations of the points of maximum displacements of the wave profiles may correlate with the trajectories of the poles of the exact solutions from the perspective of complex variables through analytic continuation. More precisely, the location of the maximum height of the rogue wave in laboratory coordinates (real space and time) is conjectured to be equal to the real part of the pole of the exact solution, if the spatial coordinate is allowed to be complex. This feature can be verified readily for the Peregrine breather (lowest order rogue wave) of the nonlinear Schrödinger equation. This connection is further demonstrated numerically here for more complicated scenarios, namely the second order rogue wave of the Boussinesq equation (for bidirectional long waves in shallow water), an asymmetric second order rogue wave for the nonlinear Schrödinger equation (as evolution system for slowly varying wave packets), and a symmetric second order rogue wave of coupled Schrödinger systems. Furthermore, the maximum displacements in physical space occur at a time instant where the trajectories of the poles in the complex plane reverse directions. This property is conjectured to hold for many other systems, and will help to determine the maximum amplitudes of rogue waves.

Impact of PCOS on early embryo cleavage kinetics.

PubMed

Wissing, M L; Bjerge, M R; Olesen, A I G; Hoest, T; Mikkelsen, A L

2014-04-01

This study investigated whether polycystic ovary syndrome (PCOS) affected early embryo development assessed by time-lapse analysis of embryo kinetics from fertilization to the blastocyst stage. This was a prospective cohort study of two pronuclei (2PN) embryos from 25 hyperandrogenic PCOS patients (110 2PN embryos), 26 normoandrogenic PCOS patients (140 2PN embryos) and 20 healthy, regularly cycling women (controls, 97 2PN embryos). Patients underwent the same baseline evaluation and the same ovarian stimulation from April 2010 to February 2013. Oocytes were fertilized by intracytoplasmic sperm injection and incubated in an EmbryoScope with pictures taken every 20 min in seven focal planes. Time to 2PN breakdown, first cleavage and cleavage to 3, 4, 5, 6, 7 and 8 cells, morula and blastocyst (t₂, t₃, t₄, t₅, t₆, t₇, t₈, t(M), t(B)) were annotated. Differences in embryo kinetics between groups were assessed by mixed modelling. Compared with controls, embryos from hyperandrogenic PCOS patients were significantly delayed at 2PN breakdown, t₂, t₃, t₄ and t₇ but not at t₅, t₆, t₈, t(M) or t(B). Embryos from hyperandrogenic PCOS women had developed slower from fertilization to the 8-cell stage compared with embryos from controls. Copyright © 2014 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.

Automated segmentation and dose-volume analysis with DICOMautomaton

NASA Astrophysics Data System (ADS)

Clark, H.; Thomas, S.; Moiseenko, V.; Lee, R.; Gill, B.; Duzenli, C.; Wu, J.

2014-03-01

Purpose: Exploration of historical data for regional organ dose sensitivity is limited by the effort needed to (sub-)segment large numbers of contours. A system has been developed which can rapidly perform autonomous contour sub-segmentation and generic dose-volume computations, substantially reducing the effort required for exploratory analyses. Methods: A contour-centric approach is taken which enables lossless, reversible segmentation and dramatically reduces computation time compared with voxel-centric approaches. Segmentation can be specified on a per-contour, per-organ, or per-patient basis, and can be performed along either an embedded plane or in terms of the contour's bounds (e.g., split organ into fractional-volume/dose pieces along any 3D unit vector). More complex segmentation techniques are available. Anonymized data from 60 head-and-neck cancer patients were used to compare dose-volume computations with Varian's EclipseTM (Varian Medical Systems, Inc.). Results: Mean doses and Dose-volume-histograms computed agree strongly with Varian's EclipseTM. Contours which have been segmented can be injected back into patient data permanently and in a Digital Imaging and Communication in Medicine (DICOM)-conforming manner. Lossless segmentation persists across such injection, and remains fully reversible. Conclusions: DICOMautomaton allows researchers to rapidly, accurately, and autonomously segment large amounts of data into intricate structures suitable for analyses of regional organ dose sensitivity.

Design of a high power TM01 mode launcher optimized for manufacturing by milling

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dal Forno, Massimo

2016-12-15

Recent research on high-gradient rf acceleration found that hard metals, such as hard copper and hard copper-silver, have lower breakdown rate than soft metals. Traditional high-gradient accelerating structures are manufactured with parts joined by high-temperature brazing. The high temperature used in brazing makes the metal soft; therefore, this process cannot be used to manufacture structures out of hard metal alloys. In order to build the structure with hard metals, the components must be designed for joining without high-temperature brazing. One method is to build the accelerating structures out of two halves, and join them by using a low-temperature technique, atmore » the symmetry plane along the beam axis. The structure has input and output rf power couplers. We use a TM01 mode launcher as a rf power coupler, which was introduced during the Next Linear Collider (NLC) work. The part of the mode launcher will be built in each half of the structure. This paper presents a novel geometry of a mode launcher, optimized for manufacturing by milling. The coupler was designed for the CERN CLIC working frequency f = 11.9942 GHz; the same geometry can be scaled to any other frequency.« less

Light scattering by hexagonal ice crystals with distributed inclusions

NASA Astrophysics Data System (ADS)

Panetta, R. Lee; Zhang, Jia-Ning; Bi, Lei; Yang, Ping; Tang, Guanlin

2016-07-01

Inclusions of air bubbles or soot particles have significant effects on the single-scattering properties of ice crystals, effects that in turn have significant impacts on the radiation budget of an atmosphere containing the crystals. This study investigates some of the single-scattering effects in the case of hexagonal ice crystals, including effects on the backscattering depolarization ratio, a quantity of practical importance in the interpretation of lidar observations. One distinguishing feature of the study is an investigation of scattering properties at a visible wavelength for a crystal with size parameter (x) above 100, a size regime where one expects some agreement between exact methods and geometrical optics methods. This expectation is generally borne out in a test comparison of how the sensitivity of scattering properties to the distribution of a given volume fraction of included air is represented using (i) an approximate Monte Carlo Ray Tracing (MCRT) method and (ii) a numerically exact pseudo-spectral time-domain (PSTD) method. Another distinguishing feature of the study is a close examination, using the numerically exact Invariant-Imbedding T-Matrix (II-TM) method, of how some optical properties of importance to satellite remote sensing vary as the volume fraction of inclusions and size of crystal are varied. Although such an investigation of properties in the x>100 regime faces serious computational burdens that force a large number of idealizations and simplifications in the study, the results nevertheless provide an intriguing glimpse of what is evidently a quite complex sensitivity of optical scattering properties to inclusions of air or soot as volume fraction and size parameter are varied.

Incompatibility and preferred morphology in the self-accommodation microstructure of β-titanium shape memory alloy

NASA Astrophysics Data System (ADS)

Inamura, T.; Hosoda, H.; Miyazaki, S.

2013-02-01

The frequency distribution of habit plane variant (HPV) clusters and the deviation from twin orientation relationships (ORs) at the junction plane (JP) are investigated by transmission electron microscopy together with theoretical evaluation of the kinematic compatibility (KC) at the JP in a β-titanium shape memory alloy. Even though there are more than 10 types of possible HPV clusters, only three types are formed. V-shaped couplings of HPVs by {111} type I twins (VI: 49%) and by ⟨211⟩ type II twins (VII: 42%) are the predominant types. A triangular morphology due to coupling of {111} type I twins is observed with a frequency of only 9%. These preferred morphologies are well explained by the degree of incompatibility (the rotation necessary for compatible connection of HPVs). The exact twin OR and KC are maintained at the JP in a VI cluster instead of KC at the habit plane (HP), whereas the JP in a VII cluster is incompatible and the ⟨211⟩ type II twin OR shows slight deviation at the JP by about 0.4°. The competition between KC at the JP and KC at the HP (invariant plane) is responsible for the frequency distribution of HPV clusters and the character of the interfaces in the self-accommodation microstructure.

Numerical simulation of granular flows : comparison with experimental results

NASA Astrophysics Data System (ADS)

Pirulli, M.; Mangeney-Castelnau, A.; Lajeunesse, E.; Vilotte, J.-P.; Bouchut, F.; Bristeau, M. O.; Perthame, B.

2003-04-01

Granular avalanches such as rock or debris flows regularly cause large amounts of human and material damages. Numerical simulation of granular avalanches should provide a useful tool for investigating, within realistic geological contexts, the dynamics of these flows and of their arrest phase and for improving the risk assessment of such natural hazards. Validation of debris avalanche numerical model on granular experiments over inclined plane is performed here. The comparison is performed by simulating granular flow of glass beads from a reservoir through a gate down an inclined plane. This unsteady situation evolves toward the steady state observed in the laboratory. Furthermore simulation exactly reproduces the arrest phase obtained by suddenly closing the gate of the reservoir once a thick flow has developped. The spreading of a granular mass released from rest at the top of a rough inclined plane is also investigated. The evolution of the avalanche shape, the velocity and the characteristics of the arrest phase are compared with experimental results and analysis of the involved forces are studied for various flow laws.

Comparison of Various Turbulence Models for Unsteady Flow around a Finite Circular Cylinder at Re=20000

NASA Astrophysics Data System (ADS)

Zhang, Di

2017-10-01

This paper compares the performance of eight Reynolds-Averaged Navier-Stokes (RANS) two-equation turbulence models and two sub-grid scale (SGS) large eddy simulation (LES) models in the scenario of unsteady flow around a finite circular cylinder at an aspect ratio (AR) of 1.0 and a Reynolds number of Re=20000. It is found that, among all the eight RANS turbulence models considered, the K-Omega-SST model (viz. SST-V2003) developed by Menter et al. [1, 2] possesses the best overall performance (being closest to the numerical results of the two LES models considered, which can be deemed as the quasi-exact solution in view of the very fine computational mesh employed by the two LES models in this study) in terms of the mean surface pressure coefficient distribution (i.e. C p ), the mean drag coefficient (i.e. C d ), the mean streamline profiles in some characteristic planes (such as the mid-height plane and the symmetry plane of the cylinder) and the distribution of mean bed-shear-stress amplification on the bottom wall.

A semi-analytical study of positive corona discharge in wire-plane electrode configuration

NASA Astrophysics Data System (ADS)

Yanallah, K.; Pontiga, F.; Chen, J. H.

2013-08-01

Wire-to-plane positive corona discharge in air has been studied using an analytical model of two species (electrons and positive ions). The spatial distributions of electric field and charged species are obtained by integrating Gauss's law and the continuity equations of species along the Laplacian field lines. The experimental values of corona current intensity and applied voltage, together with Warburg's law, have been used to formulate the boundary condition for the electron density on the corona wire. To test the accuracy of the model, the approximate electric field distribution has been compared with the exact numerical solution obtained from a finite element analysis. A parametrical study of wire-to-plane corona discharge has then been undertaken using the approximate semi-analytical solutions. Thus, the spatial distributions of electric field and charged particles have been computed for different values of the gas pressure, wire radius and electrode separation. Also, the two dimensional distribution of ozone density has been obtained using a simplified plasma chemistry model. The approximate semi-analytical solutions can be evaluated in a negligible computational time, yet provide precise estimates of corona discharge variables.

Ray propagation in oblate atmospheres. [for Jupiter

NASA Technical Reports Server (NTRS)

Hubbard, W. B.

1976-01-01

Phinney and Anderson's (1968) exact theory for the inversion of radio-occultation data for planetary atmospheres breaks down seriously when applied to occultations by oblate atmospheres because of departures from Bouguer's law. It has been proposed that this breakdown can be overcome by transforming the theory to a local spherical symmetry which osculates a ray's point of closest approach. The accuracy of this transformation procedure is assessed by evaluating the size of terms which are intrinsic to an oblate atmosphere and which are not eliminated by a local spherical approximation. The departures from Bouguer's law are analyzed, and it is shown that in the lowest-order deviation from that law, the plane of refraction is defined by the normal to the atmosphere at closest approach. In the next order, it is found that the oblateness of the atmosphere 'warps' the ray path out of a single plane, but the effect appears to be negligible for most purposes. It is concluded that there seems to be no source of serious error in making an approximation of local spherical symmetry with the refraction plane defined by the normal at closest approach.

Computer prediction of three-dimensional potential flow fields in which aircraft propellers operate. M.S. Thesis

NASA Technical Reports Server (NTRS)

Jumper, S. J.

1982-01-01

A computer program was developed to calculate the three dimensional, steady, incompressible, inviscid, irrotational flow field at the propeller plane (propeller removed) located upstream of an arbitrary airframe geometry. The program uses a horseshoe vortex of known strength to model the wing. All other airframe surfaces are modeled by a network source panels of unknown strength which is exposed to a uniform free stream and the wing-induced velocity field. By satisfying boundary conditions on each panel (the Neumann problem), relaxed boundary conditions being used on certain panels to simulate inlet inflow, the source strengths are determined. From the known source and wing vortex strengths, the resulting velocity fields on the airframe surface and at the propeller plane are obtained. All program equations are derived in detail, and a brief description of the program structure is presented. A user's manual which fully documents the program is cited. Computer predictions of the flow on the surface of a sphere and at a propeller plane upstream of the sphere are compared with the exact mathematical solutions. Agreement is good, and correct program operation is verified.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lu, Yuan; Zuo, Xu, E-mail: xzuo@nankai.edu.cn; Feng, Min

Motivated by recent theoretical predications for Dirac cone in two-dimensional (2D) triangular lattice [H. Ishizuka, Phys. Rev. Lett. 109, 237207 (2012)], first-principles studies are performed to predict Dirac cones in artificial structures of 3d transitional-metals (TM = Ti, V, Cr, Mn, Fe, Co, Ni, and Cu) doped Mg-Al spinels. In investigated artificial structures, TM dopants substitute specific positions of the B sub-lattice in Mg-Al spinel, and form a quasi-2D triangular lattice in the a-b plane. Calculated results illustrate the existence of the spin-polarized Dirac cones formed in d-wave bands at (around) the K-point in the momentum space. The study provides a promisingmore » route for engineering Dirac physics in condensed matters.« less

CO2 Push-Pull Single Fault Injection Simulations

DOE Data Explorer

Borgia, Andrea; Oldenburg, Curtis (ORCID:0000000201326016); Zhang, Rui; Pan, Lehua; Daley, Thomas M.; Finsterle, Stefan; Ramakrishnan, T.S.; Doughty, Christine; Jung, Yoojin; Lee, Kyung Jae; Altundas, Bilgin; Chugunov, Nikita

2017-09-21

ASCII text files containing grid-block name, X-Y-Z location, and multiple parameters from TOUGH2 simulation output of CO2 injection into an idealized single fault representing a dipping normal fault at the Desert Peak geothermal field (readable by GMS). The fault is composed of a damage zone, a fault gouge and a slip plane. The runs are described in detail in the following: Borgia A., Oldenburg C.M., Zhang R., Jung Y., Lee K.J., Doughty C., Daley T.M., Chugunov N., Altundas B, Ramakrishnan T.S., 2017. Carbon Dioxide Injection for Enhanced Characterization of Faults and Fractures in Geothermal Systems. Proceedings of the 42st Workshop on Geothermal Reservoir Engineering, Stanford University, Stanford, California, February 13-17.

A Study of the Jettisoning of JP-4 Fuel in the Atmosphere

DTIC Science & Technology

1975-11-01

t e r m i n e d by m e a s u r i n g the s tagna t ion p r e s s u r e with a pitot probe , shown in Fig. 21, with the s p h e r i c a l t...ip. The rod loca ted to the r igh t of the pitot probe was loca ted in the s a m e photographic plane as the suspended J P - 4 drop- le t...of Atomiza t ion in C a r b u r e t o r s . " NACA TM 518, 1929. 13. Lapple , C. E . , Henry , J . P . , J r . , and Blake, D. E. " A t o

Sagittal and transversal plane deformity in thoracic scoliosis.

PubMed

Kotwicki, Tomasz

2002-01-01

The aim of the study was to assess the sagittal and transversal plane deformity of the spine in thoracic scoliosis by the mean of 3-D radiographic analysis. 46 patients admitted for surgery for thoracic idiopathic scoliosis underwent preoperative radiographic assessment. All patients presented the same pattern of the coronal plane deformity: single right thoracic curve (Lenke 1, King 3). Neither lumbar nor proximal thoracic structural curve were present. The Cobb angle varied from 41gamma to 77 gamma (mean 55,4 gamma +/- 8,6 gamma). Long cassette standing antero-posterior and lateral radiographs were analysed. Three-dimensional reconstruction with Rachis 91TM software was performed for each pair of radiographs. The following parameters were assessed: sagittal thoracic Cobb angle (Th4-Th12), upper thoracic kyphosis angle (Th5-Th8), lower thoracic kyphosis angle (Th9-Th12), superior and inferior hemi-curve sagittal angles, lumbar lordosis, sacral slope, sacral incidence, vertebral plate index, segmental vertebral axial rotation throughout the thoracic and lumbar spine. Results showed great variability of parameters assessed. The non-harmonious distribution of kyphosis was demonstrated in the thoracic spine. Local Th9-Th12 hypokyphosis and adjacent local Th5-Th8 hyperkyphosis constitute the most typical sagittal pathologies. So called normokyphotic curves were composed of one hyperkyphotic and one hypokyphotic zone. Th1-Th4 segment revealed two patterns of segmental rotation distribution: a purely compensatory curve with no vertebral axial rotation or a rotated curve presenting the morphology intermediate between Lenke 1 and Lenke 2 types (or King 3 and King 5). curves presenting the same coronal plane deformity differ in their morphology assessed in the two other planes; global thoracic kyphosis angle is a misleading parameter because it covers hypo- and hyperkyphotic zones; local distal thoracic (Th9-Th12) hypokyphosis is present in idiopathic thoracic scoliosis.

Nonlinear modes of the tensor Dirac equation and CPT violation

NASA Technical Reports Server (NTRS)

Reifler, Frank J.; Morris, Randall D.

1993-01-01

Recently, it has been shown that Dirac's bispinor equation can be expressed, in an equivalent tensor form, as a constrained Yang-Mills equation in the limit of an infinitely large coupling constant. It was also shown that the free tensor Dirac equation is a completely integrable Hamiltonian system with Lie algebra type Poisson brackets, from which Fermi quantization can be derived directly without using bispinors. The Yang-Mills equation for a finite coupling constant is investigated. It is shown that the nonlinear Yang-Mills equation has exact plane wave solutions in one-to-one correspondence with the plane wave solutions of Dirac's bispinor equation. The theory of nonlinear dispersive waves is applied to establish the existence of wave packets. The CPT violation of these nonlinear wave packets, which could lead to new observable effects consistent with current experimental bounds, is investigated.

Polynomial interpretation of multipole vectors

NASA Astrophysics Data System (ADS)

Katz, Gabriel; Weeks, Jeff

2004-09-01

Copi, Huterer, Starkman, and Schwarz introduced multipole vectors in a tensor context and used them to demonstrate that the first-year Wilkinson microwave anisotropy probe (WMAP) quadrupole and octopole planes align at roughly the 99.9% confidence level. In the present article, the language of polynomials provides a new and independent derivation of the multipole vector concept. Bézout’s theorem supports an elementary proof that the multipole vectors exist and are unique (up to rescaling). The constructive nature of the proof leads to a fast, practical algorithm for computing multipole vectors. We illustrate the algorithm by finding exact solutions for some simple toy examples and numerical solutions for the first-year WMAP quadrupole and octopole. We then apply our algorithm to Monte Carlo skies to independently reconfirm the estimate that the WMAP quadrupole and octopole planes align at the 99.9% level.

Numerical modelling of GPR ground-matching enhancement by a chirped multilayer structure - output of cooperation within COST Action TU1208

NASA Astrophysics Data System (ADS)

Baghdasaryan, Hovik V.; Knyazyan, Tamara M.; Hovhannisyan, Tamara. T.; Marciniak, Marian; Pajewski, Lara

2016-04-01

As is well know, Ground Penetrating Radar (GPR) is an electromagnetic technique for the detection and imaging of buried objects, with resolution ranging from centimeters to few meters [1, 2]. Though this technique is mature enough and different types of GPR devices are already in use, some problems are still waiting for their solution [3]. One of them is to achieve a better matching of transmitting GPR antenna to the ground, that will increase the signal penetration depth and the signal/noise ratio at the receiving end. In the current work, a full-wave electromagnetic modelling of the interaction of a plane wave with a chirped multilayered structure on the ground is performed, via numerical simulation. The method of single expression is used, which is a suitable technique for multi-boundary problems solution [4, 5]. The considered multilayer consists of two different dielectric slabs of low and high permittivity, where the highest value of permittivity doesn't exceed the permittivity of the ground. The losses in the ground are suitably taken into account. Two types of multilayers are analysed. Numerical results are obtained for the reflectance from the structure, as well as for the distributions of electric field components and power flow density in both the considered structures and the ground. The obtained results indicate that, for a better matching with the ground, the layer closer to the ground should be the high-permittivity one. Acknowledgement This work benefited from networking activities carried out within the EU funded COST Action TU1208 "Civil Engineering Applications of Ground Penetrating Radar" (www.GPRadar.eu, www.cost.eu). Part of this work was developed during the Short-Term Scientific Mission COST-STSM-TU1208-25016, carried out by Prof. Baghdasaryan in the National Institute of Telecommunications in Warsaw, Poland. References [1] H. M. Jol. Ground Penetrating Radar: Theory and Applications. Elsevier, 2009. 509 pp. [2] R. Persico. Introduction to Ground Penetrating Radar. IEEE Press, Wiley, 2014. 368 pp. [3] A. Benedetto, L. Pajewski. Civil Engineering Applications of Ground Penetrating Radar. Springer, 2015. 371 pp. [4] H.V. Baghdasaryan, T.M. Knyazyan, "Problem of Plane EM-Wave Self-action in Multilayer Structure: an Exact Solution", Optical and Quantum Electronics, vol. 31, 1999, pp. 1059-1072. [5] H.V. Baghdasaryan, "Basics of the Method of Single Expression: New Approach for Solving Boundary Problems in Classical Electrodynamics", Yerevan, Chartaraget, 2013.

GABAA receptors: Various stoichiometrics of subunit arrangement in α1β3 and α1β3ε receptors.

PubMed

Has, Ahmad Tarmizi Che; Chebib, Mary

2018-05-15

GABAA receptors (GABAARs) are members of the Cys-loop ligand-gated ion channel (LGIC) superfamily, which includes nicotinic acetylcholine, glycine, and serotonin (5HT3) receptors [1,2,3,4]. LGICs typically mediate fast synaptic transmission via the movement of ions through channels gated by neurotransmitters, such as acetylcholine for nicotinic receptors and GABA for GABAARs [5]. The term Cys-loop receptors originates from the presence of a conserved disulphide bond (or bridge) which holds together two cysteine amino acids of the loop that forms from the structure of polypeptides in the extracellular domain of the receptor's subunit [6]. GABAARs are pentameric transmembrane protein complexes consisting of five subunits from a variety of polypeptide subunits [7,8]. All of these subunits are pseudo-symmetrically organized in the plane of the membrane, with a Cl--selective channel in the middle of the complex. To date, nineteen GABAAR subunits have been identified and categorized into eight classes, α1-6, β1-3, γ1-3, δ, ε, θ, π and ρ1-3, but their variety is further broadened by the existence of several splice forms for certain subunits (e.g., α6, β2 and γ2) [9,10,11,12]. The subunits within each class have an amino acid sequence homology of 70% or more, whereas those with a sequence homology of 30% or less are grouped into different classes [13,14]. A subunit consists of four transmembrane domains (TM1-TM4), each forming an α-helix; a large extracellular N-terminal domain that incorporates part of the orthosteric agonist/antagonist binding site; a large intracellular loop between the TM3 and TM4; a small intracellular loop between TM1 and TM2; a small extracellular loop between TM2 and TM3; and a C-terminal extracellular domain [15,16]. Each subunit is arranged in such a way as to create principal and complementary interfaces with the other subunits, and in a position such that the TM2 of each subunit forms the wall of the channel pore [17,18,19]. The major subunit combination found in the brain comprises α1, β2 and γ2 subunits with the stoichiometry 2α1:2β2:1γ2 [18,20]. For the GABAA α1β2γ2 receptors, the subunits form a specific arrangement in which α1 and β2 subunits alternate with each other and are connected by a γ2 subunit (Figure A) [16,20,21]. For minor subtypes, different α and β subunits have been detected to co-exist as proven by the existence of GABAARs containing α1α2, α1α3, α1α5, α2α3, α3α5, α4α1, α4α2 and α4α3 in the central nervous system [22,23]. Meanwhile, the same pattern has been detected with β and γ subunits, at least the co-occurrence of β in the same GABAAR as well as γ2 with γ3, indicating that these subunits have the capacity to co-exist with each other [24,25,26]. Since different subunits can actually occur in one receptor, GABAARs are considered to exist in a multi-subunit arrangement, leading to ambiguity in the determination of a receptor's stoichiometry. In this review, we first briefly discuss the different subunit arrangements of α1 and β3 subunits in the binary α1β3 receptors. Then we review the GABAA ε-containing receptors predominantly in terms of the ability of ε subunit to present in different position in the ternary α1β3ε receptors, which introduce distinct populations of receptor. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

Twin and habit plane microstructures due to the tetragonal to monoclinic transformation of zirconia

NASA Astrophysics Data System (ADS)

Simha, N. K.

1997-02-01

We first construct Bain strains for the tetragonal to monoclinic ( t → m) transformation of zirconia (ZrO 2), and then examine the resulting twin and habit plane microstructures. The ( t → m) transformation in zirconia occurs via two paths; transformation along path I has two Bain strains that involve shearing of a rectangular face of the tetragonal unit cell, and shearing of the square base corresponds to path II. The monoclinic variants resulting from each of the three Bain strains can form 12 twins, and four of the twins corresponding to path II are neither of type I nor of type II. Habit planes do not exist for the transformation along path I, whereas transformation along path II has: (± 0.8139, ± 0.3898, - 0.4309) t, (± 0.6489, ± 0.6271, - 0.4309) t, (± 0.7804, ± 0.4530, - 0.4309) t. We predict the exact twin planes observed by Bailey [(1964) Phase transformation at high temperatures in hafnia and zirconia. Proc. Roy. Soc.279A, 395-412], Bansal and Heuer [(1972) On a martensitic phase transformation in Zirconia ZrO 2—I. Metallographic evidence. Acta Metall.20, 1281-1289] and Buljan et al. [(1976) Optical and X-ray single crystal studies of the monoclinic ↔ tetragonal transition in ZrO 2. J. Am. Ceram. Soc.59, 351-354]; additional twins and habit planes that we predict have not yet been observed.

Computed tomographic features of adenocarcinoma compared to malignant lymphoma of the stomach.

PubMed

Chamadol, Nittaya; Wongwiwatchai, Jitraporn; Wachirakowit, Tharinee; Pairojkul, Chawalit

2011-11-01

To compare the CT findings of adenocarcinoma and malignant lymphoma of the stomach. The authors retrospectively reviewed the computed tomographic images of 21 patients who received a definite pathologic diagnosis of adenocarcinoma or malignant lymphoma of the stomach. The images were taken at Srinagarind Hospital between January 2006 and February 2009. Seventeen patients with gastric adenocarcinoma and four with malignant gastric lymphoma were included in the present study. The pattern of involvement, the location of lesion, the perigastric fat plane, the perigastric lymphadenopathy and the extension of disease on CT images were evaluated and analyzed by Chi-square and Fisher exact tests. There was a statistically significant difference between gastric adenocarcinoma and malignant gastric lymphoma in the pattern of involvement of disease (p = 0.010), the perigastric fat plane (p = 0.002) and the location of disease (p = 0.008). By contrast, there was no respective statistically significant difference in the perigastric lymphadenopathy (p = 0.950) and the extension of disease (p = 0.175) in between gastric adenocarcinoma and malignant gastric lymphoma. The CT findings helpful for differentiating gastric adenocarcinoma from malignant gastric lymphoma are the pattern of involvement, the perigastric fat plane, and the location of lesion. Localized involvement of the lesion, abnormal perigastric fat plane and location involving one region of the stomach tend to indicate gastric adenocarcinoma; while diffused involvement of the lesion, preserved perigastric fat plane and location involving more than one region of the stomach tend to indicate malignant gastric lymphoma.

FAST TRACK COMMUNICATION: Two interacting atoms in a cavity: exact solutions, entanglement and decoherence

NASA Astrophysics Data System (ADS)

Torres, J. M.; Sadurní, E.; Seligman, T. H.

2010-05-01

We address the problem of two interacting atoms of different species inside a cavity and find the explicit solutions of the corresponding eigenvalues and eigenfunctions using a new variant. This model encompasses various commonly used models. By way of example we obtain closed expressions for concurrence and purity as a function of time for the case where the cavity is prepared in a number state. We discuss the behaviour of these quantities and their relative behaviour in the concurrence-purity plane.

On higher order discrete phase-locked loops.

NASA Technical Reports Server (NTRS)

Gill, G. S.; Gupta, S. C.

1972-01-01

An exact mathematical model is developed for a discrete loop of a general order particularly suitable for digital computation. The deterministic response of the loop to the phase step and the frequency step is investigated. The design of the digital filter for the second-order loop is considered. Use is made of the incremental phase plane to study the phase error behavior of the loop. The model of the noisy loop is derived and the optimization of the loop filter for minimum mean-square error is considered.

Active Exhaust Silencing Systen For the Management of Auxillary Power Unit Sound Signatures

DTIC Science & Technology

2014-08-01

conceptual mass-less pistons are introduced into the system before and after the injection site, such that they will move exactly with the plane wave...Unit Sound Signatures, Helminen, et al. Page 2 of 7 either the primary source or the injected source. It is assumed that the pistons are ‘close...source, it causes both pistons to move identically. The pressures induced by the flow on the pistons do not affect the flow generated by the

Nonlinear propagation of electromagnetic waves in negative-refraction-index composite materials.

PubMed

Kourakis, I; Shukla, P K

2005-07-01

We investigate the nonlinear propagation of electromagnetic waves in left-handed materials. For this purpose, we consider a set of coupled nonlinear Schrödinger (CNLS) equations, which govern the dynamics of coupled electric and magnetic field envelopes. The CNLS equations are used to obtain a nonlinear dispersion, which depicts the modulational stability profile of the coupled plane-wave solutions in left-handed materials. An exact (in)stability criterion for modulational interactions is derived, and analytical expressions for the instability growth rate are obtained.

The nonconvex multi-dimensional Riemann problem for Hamilton-Jacobi equations

NASA Technical Reports Server (NTRS)

Osher, Stanley

1989-01-01

Simple inequalities for the Riemann problem for a Hamilton-Jacobi equation in N space dimension when neither the initial data nor the Hamiltonian need be convex (or concave) are presented. The initial data is globally continuous, affine in each orthant, with a possible jump in normal derivative across each coordinate plane, x sub i = 0. The inequalities become equalities wherever a maxmin equals a minmax and thus an exact closed form solution to this problem is then obtained.

Influence of the random walk finite step on the first-passage probability

NASA Astrophysics Data System (ADS)

Klimenkova, Olga; Menshutin, Anton; Shchur, Lev

2018-01-01

A well known connection between first-passage probability of random walk and distribution of electrical potential described by Laplace equation is studied. We simulate random walk in the plane numerically as a discrete time process with fixed step length. We measure first-passage probability to touch the absorbing sphere of radius R in 2D. We found a regular deviation of the first-passage probability from the exact function, which we attribute to the finiteness of the random walk step.

Tilted string cosmologies

NASA Astrophysics Data System (ADS)

Clancy, Dominic; Feinstein, Alexander; Lidsey, James E.; Tavakol, Reza

1999-04-01

Global symmetries of the string effective action are employed to generate tilted, homogeneous Bianchi type VIh string cosmologies from a previously known stiff perfect fluid solution to Einstein gravity. The dilaton field is not constant on the surfaces of homogeneity. The future asymptotic state of the models is interpreted as a plane wave and is itself an exact solution to the string equations of motion to all orders in the inverse string tension. An inhomogeneous generalization of the Bianchi type III model is also found.

Electromagnetic fields radiated from a lightning return stroke - Application of an exact solution to Maxwell's equations

NASA Technical Reports Server (NTRS)

Le Vine, D. M.; Meneghini, R.

1978-01-01

A solution is presented for the electromagnetic fields radiated by an arbitrarily oriented current filament over a conducting ground plane in the case where the current propagates along the filament at the speed of light, and this solution is interpreted in terms of radiation from lightning return strokes. The solution is exact in the fullest sense; no mathematical approximations are made, and the governing differential equations and boundary conditions are satisfied. The solution has the additional attribute of being specified in closed form in terms of elementary functions. This solution is discussed from the point of view of deducing lightning current wave forms from measurements of the electromagnetic fields and understanding the effects of channel tortuosity on the radiated fields. In addition, it is compared with two approximate solutions, the traditional moment approximation and the Fraunhofer approximation, and a set of criteria describing their applicability are presented and interpreted.

New exact solutions of the Dirac and Klein-Gordon equations of a charged particle propagating in a strong laser field in an underdense plasma

NASA Astrophysics Data System (ADS)

Varró, Sándor

2014-03-01

Exact solutions are presented of the Dirac and Klein-Gordon equations of a charged particle propagating in a classical monochromatic electromagnetic plane wave in a medium of index of refraction nm<1. In the Dirac case the solutions are expressed in terms of new complex polynomials, and in the Klein-Gordon case the found solutions are expressed in terms of Ince polynomials. In each case they form a doubly infinite set, labeled by two integer quantum numbers. These integer numbers represent quantized momentum components of the charged particle along the polarization vector and along the propagation direction of the electromagnetic radiation. Since this radiation may represent a plasmon wave of arbitrary high amplitude, propagating in an underdense plasma, the solutions obtained may have relevance in describing possible quantum features of novel acceleration mechanisms.

Laser Radiation in Active Amplifying Media Treated as a Transport Problem - Transfer Equation Derived and Exactly Solved

NASA Astrophysics Data System (ADS)

Das Gupta, Santanu; Das Gupta, S. R.

1991-10-01

The flow of laser radiation in a plane-parallel cylindrical slab of active amplifying medium with axial symmetry is treated as a problem in radiative transfer. The appropriate one-dimensional transfer equation describing the transfer of laser radiation has been derived by an appeal to Einstein'sA, B coefficients (describing the processes of stimulated line absorption, spontaneous line emission, and stimulated line emission sustained by population inversion in the medium) and considering the ‘rate equations’ to completely establish the rational of the transfer equation obtained. The equation is then exactly solved and the angular distribution of the emergent laser beam intensity is obtained; its numerically computed values are given in tables and plotted in graphs showing the nature of peaks of the emerging laser beam intensity about the axis of the laser cylinder.

Exact moduli space metrics for hyperbolic vortex polygons

DOE Office of Scientific and Technical Information (OSTI.GOV)

Krusch, S.; Speight, J. M.

2010-02-15

Exact metrics on some totally geodesic submanifolds of the moduli space of static hyperbolic N-vortices are derived. These submanifolds, denoted as {sigma}{sub n,m}, are spaces of C{sub n}-invariant vortex configurations with n single vortices at the vertices of a regular polygon and m=N-n coincident vortices at the polygon's center. The geometric properties of {sigma}{sub n,m} are investigated, and it is found that {sigma}{sub n,n-1} is isometric to the hyperbolic plane of curvature -(3{pi}n){sup -1}. The geodesic flow on {sigma}{sub n,m} and a geometrically natural variant of geodesic flow recently proposed by Collie and Tong ['The dynamics of Chern-Simons vortices', Phys.more » Rev. D Part. Fields Gravit. Cosmol. 78, 065013 (2008);e-print arXiv:hep-th/0805.0602] are analyzed in detail.« less

Geometrically derived difference formulae for the numerical integration of trajectory problems

NASA Technical Reports Server (NTRS)

Mcleod, R. J. Y.; Sanz-Serna, J. M.

1982-01-01

An initial value problem for the autonomous system of ordinary differential equations dy/dt = f(y), where y is a vector, is considered. In a number of practical applications the interest lies in obtaining the curve traced by the solution y. These applications include the computation of trajectories in mechanical problems. The term 'trajectory problem' is employed to refer to these cases. Lambert and McLeod (1979) have introduced a method involving local rotation of the axes in the y-plane for the two-dimensional case. The present investigation continues the study of difference schemes specifically derived for trajectory problems. A simple geometrical way of constructing such methods is presented, and the local accuracy of the schemes is investigated. A circularly exact, fixed-step predictor-corrector algorithm is defined, and a variable-step version of a circularly exact algorithm is presented.

Spectral characteristics and the extent of paleosols of the Palouse formation

NASA Technical Reports Server (NTRS)

Frazier, B. E.; Busacca, A.; Cheng, Y.; Wherry, D.; Hart, J.; Gill, S.

1986-01-01

Spectral relationships were investigated for several bare soil fields which were in summer fallow rotation on the date of the imagery. Printouts of each band were examined and compared to aerial photography. Bands with dissimilar reflectance patterns for known areas were then combined using ratio techniques which were proven useful in other studies (Williams, 1983). Selected ratios were Thematic Mapper (TM) 1/TM4, TM3/TM4, and TM5/TM4. Cluster analyses and Baysian and Fastclass classifier images were produced using the three ratio images. Plots of cluster analysis outputs revealed distinct groupings of reflectance data representing green crops, ripened crops, soil and green plants, and bare soil. Bare soil was represented by a line of clusters on plots of the ratios TM5/TM4 and TM3/TM4. The soil line was investigated further to determine factors involved in the distributin of clusters alone the line. The clusters representing the bare soil line were also studied by plotting the Tm5/TM4, TM1/TM4 dimension. A total of 76 soil samples were gathered and analyzed for organic carbon.

Microelectromechanically tunable multiband metamaterial with preserved isotropy

NASA Astrophysics Data System (ADS)

Pitchappa, Prakash; Ho, Chong Pei; Qian, You; Dhakar, Lokesh; Singh, Navab; Lee, Chengkuo

2015-06-01

We experimentally demonstrate a micromachined reconfigurable metamaterial with polarization independent characteristics for multiple resonances in terahertz spectral region. The metamaterial unit cell consists of eight out-of-plane deformable microcantilevers placed at each corner of an octagon ring. The octagon shaped unit cell geometry provides the desired rotational symmetry, while the out-of-plane movable cantilevers preserves the symmetry at different configurations of the metamaterial. The metamaterial is shown to provide polarization independent response for both electrical inductive-capacitive (eLC) resonance and dipolar resonance at all states of actuation. The proposed metamaterial has a switching range of 0.16 THz and 0.37 THz and a transmission intensity change of more than 0.2 and 0.7 for the eLC and dipolar resonances, respectively for both TE and TM modes. Further optimization of the metal layer thickness, provides an improvement of up to 80% modulation at 0.57 THz. The simultaneously tunable dual band isotropic metamaterial will enable the realization of high performance electro-optic devices that would facilitate numerous terahertz applications such as compressive terahertz imaging, miniaturized terahertz spectroscopy and next generation high speed wireless communication possible in the near future.

Plasma-based polarizer and waveplate at large laser intensity

NASA Astrophysics Data System (ADS)

Lehmann, G.; Spatschek, K. H.

2018-06-01

A plasma photonic crystal consists of a plasma density grating which is created in underdense plasma by counterpropagating laser beams. When a high-power laser pulse impinges the crystal, it might be reflected or transmitted. So far only one type of pulse polarization, namely the so-called s wave (or TE mode) was investigated (when the electric field vector is perpendicular to the plane of incidence). Here, when investigating also so-called p waves (or TM modes, where the magnetic field vector is perpendicular to the plane of incidence), it is detected that the transmission and reflection properties of the plasma photonic crystal depend on polarization. A simple analytic model of the crystal allows one to make precise predictions. The first conclusion is that in some operational regime the crystal can act as a plasma polarizer for high-intensity laser pulses. Also, differences in phase velocities for grazing incidence between s and p polarization are found. Thus, secondly, the crystal can be utilized as a waveplate, e.g., transforming linearly polarized laser light into circular polarization. All these processes extend to laser intensities beyond the damage intensities of so far used solid state devices.

Thermodynamics of the Electric Field Induced Orientation of Nematic Droplet/Polymer Films

NASA Astrophysics Data System (ADS)

Drzaic, Paul S.

1989-07-01

Films consisting of micron-sized nematic liquid crystal droplets dispersed in a polymer matrix (NCAP) represent an important new class of electro-optical devices. These films strongly scatter light in the tm powered state, but achieve a high degree of clarity when an electric field is applied. In this report we describe the aspects of liquid crystal and polymer composition that control the magnitude of the electric field required to orient the nematic droplets. The droplet shape is found to be an important factor in the electro-optical response of these films. In films deposited from aqueous solutions the nematic cavities in the film are usually oblate in nature, with the short axis perpendicular to the film plane. The nematic, which adopts a bipolar configuration within the cavity, is preferentially aligned so that each droplet's symmetry axis is aligned parallel to the film plane in the rest state, but rotates to lie parallel with the field in the powered state. Capacitance data is presented which supports this picture. It is shown that the nematic droplet shape can be a major factor in determining the thermodynamics of droplet orientation.

Validity and Reliability of a Virtual Reality Game in Evaluating the Projected Frontal Plane Knee Angle When Landing From a Drop Vertical Jump.

PubMed

Mills, Kathryn; Idris, Aula; Pham, Thu-An; Porte, John; Wiggins, Mark; Kavakli, Manolya

2017-12-18

To determine the validity and reliability of the peak frontal plane knee angle evaluated by a virtual reality (VR) netball game when landing from a drop vertical jump (DVJ). Laboratory Methods: Forty participants performed 3 DVJs evaluated by 3-dimensional (3D) motion analysis and 3 DVJs evaluated by the VR game. Limits of agreement for the peak projected frontal plane knee angle and peak knee abduction were determined. Participants were given a consensus category of "Above threshold" or "Below threshold" based on a pre-specified threshold angle of 9˚ during landing. Classification agreement was determined using kappa coefficient and accuracy was determined using specificity and sensitivity. Ten participants returned 1-week later to determine intra-rater reliability, standard error of the measure and typical error. The mean difference in detected frontal plane knee angle was 3.39˚ (1.03˚, 5.74˚). Limits of agreement were -10.27˚ (-14.36˚, -6.19˚) to 17.05˚ (12.97˚, 21.14˚). Substantial agreement, specificity and sensitivity were observed for the threshold classification (ĸ = 0.66, [0.42, 0.88] specificity= 0.96 [0.78, 1.0], sensitivity= 0.75 [0.43, 0.95]). The game exhibited acceptable reliability over time (ICC (3,1) = 0.844) and error was approximately 2˚. The VR game reliably evaluated a projected frontal plane knee angle. While the knee angle detected by the VR game is strongly related peak knee abduction, the accuracy of detecting the exact angle was limited. A threshold approach may be a more accurate approach for gaming technology to evaluate frontal plane knee angles when landing from a jump.

Growth and optical characteristics of Tm-doped AlGaN layer grown by organometallic vapor phase epitaxy

NASA Astrophysics Data System (ADS)

Takatsu, J.; Fuji, R.; Tatebayashi, J.; Timmerman, D.; Lesage, A.; Gregorkiewicz, T.; Fujiwara, Y.

2018-04-01

We report on the growth and optical properties of Tm-doped AlGaN layers by organometallic vapor phase epitaxy (OMVPE). The morphological and optical properties of Tm-doped GaN (GaN:Tm) and Tm-doped AlGaN (AlGaN:Tm) were investigated by Nomarski differential interference contrast microscopy and photoluminescence (PL) characterization. Nomarski images reveal an increase of surface roughness upon doping Tm into both GaN and AlGaN layers. The PL characterization of GaN:Tm shows emission in the near-infrared range originating from intra-4f shell transitions of Tm3+ ions. In contrast, AlGaN:Tm also exhibits blue light emission from Tm3+ ions. In that case, the wider band gap of the AlGaN host allows energy transfer to higher states of the Tm3+ ions. With time-resolved PL measurements, we could distinguish three types of luminescent sites of Tm3+ in the AlGaN:Tm layer, having different decay times. Our results confirm that Tm ions can be doped into GaN and AlGaN by OMVPE, and show potential for the fabrication of novel high-color-purity blue light emitting diodes.

[Research advances in CKLF-like MARVEL transmembrane domain containing member 5].

PubMed

Yuan, Ye-qing; Xiao, Yun-bei; Liu, Zhen-hua; Zhang, Xiao-wei; Xu, Tao; Wang, Xiao-feng

2012-12-01

CKLF-like MARVEL transmembrane domain containing member(CMTM)is a novel generic family firstly reported by Peking University Center for Human Disease Genomics. CMTM5 belongs to this family and has exhibited tumor-inhibiting activities. It can encode proteins approaching to the transmembrane 4 superfamily(TM4SF). CMTM5 is broadly expressed in normal adult and fetal human tissues, but is undetectable or down-regulated in most carcinoma cell lines and tissues. Restoration of CMTM5 may inhibit the proliferation, migration, and invasion of carcinoma cells. Although the exact mechanism of its anti-tumor activity remains unclear, CMTM5 may be involved in various signaling pathways governing the occurrence and development of tumors. CMTM5 may be a new target in the gene therapies for tumors, while further studies on CMTM5 and its anti-tumor mechanisms are warranted.

Preliminary evaluation of the landsat-4 thematic mapper data for mineral exploration

USGS Publications Warehouse

Podwysocki, M.H.; Power, M.S.; Jones, O.D.

1985-01-01

Landsat-4 Thematic Mapper (TM) data recorded over an arid terrain were analyzed to determine the applicability of using of TM data for identifying and mapping hydrothermally altered, potentially mineralized rocks. Clays, micas, and other minerals bearing the OH anion in specific crystal lattice positions have absorption bands in the 2.2-??m region (TM channel 7, TM7) and commonly lack features in the 1.6-??m region (TM5). Channel ratios TM5/TM7, TM5/TM4, and TM3/TM1 were combined into a color-ratio-composite (CRC) image and used to distinguish hydrothermally altered rocks, unaltered rocks, and vegetation. These distinctions are made possible by using the TM5 and TM7, channels which are not available in the Landsat multispectral scanner (MSS). Digital masking was used to eliminate ambiguities due to water and shadows. However, some ambiguities in identification resulted between altered volcanic rocks and unaltered sedimentary deposits that contained clays, carbonates, and gypsum, and between altered volcanic rocks and volcanic tuffs diagenetically altered to zeolites. However, compared to MSS data, TM data should greatly improve the ability to map hydrothermally altered rocks in arid terrains. ?? 1985.

Continuous Easy-Plane Deconfined Phase Transition on the Kagome Lattice

NASA Astrophysics Data System (ADS)

Zhang, Xue-Feng; He, Yin-Chen; Eggert, Sebastian; Moessner, Roderich; Pollmann, Frank

2018-03-01

We use large scale quantum Monte Carlo simulations to study an extended Hubbard model of hard core bosons on the kagome lattice. In the limit of strong nearest-neighbor interactions at 1 /3 filling, the interplay between frustration and quantum fluctuations leads to a valence bond solid ground state. The system undergoes a quantum phase transition to a superfluid phase as the interaction strength is decreased. It is still under debate whether the transition is weakly first order or represents an unconventional continuous phase transition. We present a theory in terms of an easy plane noncompact C P1 gauge theory describing the phase transition at 1 /3 filling. Utilizing large scale quantum Monte Carlo simulations with parallel tempering in the canonical ensemble up to 15552 spins, we provide evidence that the phase transition is continuous at exactly 1 /3 filling. A careful finite size scaling analysis reveals an unconventional scaling behavior hinting at deconfined quantum criticality.

Plane Symmetric Dark Energy Models in the Form of Wet Dark Fluid in f ( R, T) Gravity

NASA Astrophysics Data System (ADS)

Chirde, V. R.; Shekh, S. H.

2016-06-01

In this paper, we have investigated the plane symmetric space-time with wet dark fluid (WDF), which is a candidate for dark energy, in the framework of f ( R, T) gravity Harko et al. 2011, Phys. Rev. D, 84, 024020), where R and T denote the Ricci scalar and the trace of the energy-momentum tensor respectively. We have used the equation of state in the form of WDF for the dark energy component of the Universe. It is modeled on the equation of state p = ω( ρ - ρ ∗). The exact solutions to the corresponding field equations are obtained for power-law and exponential volumetric expansion. The geometrical and physical parameters for both the models are studied. Also, we have discussed the well-known astrophysical phenomena, namely the look-back time, proper distance, the luminosity distance and angular diameter distance with red shift.

Fourier transform digital holographic adaptive optics imaging system

PubMed Central

Liu, Changgeng; Yu, Xiao; Kim, Myung K.

2013-01-01

A Fourier transform digital holographic adaptive optics imaging system and its basic principles are proposed. The CCD is put at the exact Fourier transform plane of the pupil of the eye lens. The spherical curvature introduced by the optics except the eye lens itself is eliminated. The CCD is also at image plane of the target. The point-spread function of the system is directly recorded, making it easier to determine the correct guide-star hologram. Also, the light signal will be stronger at the CCD, especially for phase-aberration sensing. Numerical propagation is avoided. The sensor aperture has nothing to do with the resolution and the possibility of using low coherence or incoherent illumination is opened. The system becomes more efficient and flexible. Although it is intended for ophthalmic use, it also shows potential application in microscopy. The robustness and feasibility of this compact system are demonstrated by simulations and experiments using scattering objects. PMID:23262541

Scattering of Gaussian Beams by Disordered Particulate Media

NASA Technical Reports Server (NTRS)

Mishchenko, Michael I.; Dlugach, Janna M.

2016-01-01

A frequently observed characteristic of electromagnetic scattering by a disordered particulate medium is the absence of pronounced speckles in angular patterns of the scattered light. It is known that such diffuse speckle-free scattering patterns can be caused by averaging over randomly changing particle positions and/or over a finite spectral range. To get further insight into the possible physical causes of the absence of speckles, we use the numerically exact superposition T-matrix solver of the Maxwell equations and analyze the scattering of plane-wave and Gaussian beams by representative multi-sphere groups. We show that phase and amplitude variations across an incident Gaussian beam do not serve to extinguish the pronounced speckle pattern typical of plane-wave illumination of a fixed multi-particle group. Averaging over random particle positions and/or over a finite spectral range is still required to generate the classical diffuse speckle-free regime.

Web flexibility and I-beam torsional oscillation

NASA Astrophysics Data System (ADS)

Stephen, N. G.; Wang, P. J.

1986-08-01

Two recent theories on torsional oscillation of general doubly-symmetric non-circular cross-section beams incorporate a second order effect, that of in-plane shear deformation involving a change in cross-sectional shape, and are found to give excellent agreement with exact results for an elliptical section rod. For "technical" torsional oscillation theories of I-section beams this in-plane shear has previously been considered within the flanges only; in the present work the greater effect of shear distortion of the web is included, having previously been considered only in static analysis. The theory predicts three modes of wave propagation, one of which is essentially torsional in character; a second mode may be identified with predominatly flange bending according to the second branch of Timoshenko beam theory whilst a new mode involves individual flange torsion with asymmetric web deformation, and has the lowest phase velocity except at the longest wavelength. An alternative symmetric web deformation is also considered.

Second order modeling of boundary-free turbulent shear flows

NASA Technical Reports Server (NTRS)

Shih, T.-H.; Chen, Y.-Y.; Lumley, J. L.

1991-01-01

A set of realizable second order models for boundary-free turbulent flows is presented. The constraints on second order models based on the realizability principle are re-examined. The rapid terms in the pressure correlations for both the Reynolds stress and the passive scalar flux equations are constructed to exactly satisfy the joint realizability. All other model terms (return-to-isotropy, third moments, and terms in the dissipation equations) already satisfy realizability. To correct the spreading rate of the axisymmetric jet, an extra term is added to the dissipation equation which accounts for the effect of mean vortex stretching on dissipation. The test flows used in this study are the mixing shear layer, plane jet, axisymmetric jet, and plane wake. The numerical solutions show that the unified model equations predict all these flows reasonably. It is expected that these models would be suitable for more complex and critical flows.

Spatial carrier color digital speckle pattern interferometry for absolute three-dimensional deformation measurement

NASA Astrophysics Data System (ADS)

Gao, Xinya; Wang, Yonghong; Li, Junrui; Dan, Xizuo; Wu, Sijin; Yang, Lianxiang

2017-06-01

It is difficult to measure absolute three-dimensional deformation using traditional digital speckle pattern interferometry (DSPI) when the boundary condition of an object being tested is not exactly given. In practical applications, the boundary condition cannot always be specifically provided, limiting the use of DSPI in real-world applications. To tackle this problem, a DSPI system that is integrated by the spatial carrier method and a color camera has been established. Four phase maps are obtained simultaneously by spatial carrier color-digital speckle pattern interferometry using four speckle interferometers with different illumination directions. One out-of-plane and two in-plane absolute deformations can be acquired simultaneously without knowing the boundary conditions using the absolute deformation extraction algorithm based on four phase maps. Finally, the system is proved by experimental results through measurement of the deformation of a flat aluminum plate with a groove.

Stem Cells in the Trabecular Meshwork for Regulating Intraocular Pressure.

PubMed

Yun, Hongmin; Zhou, Yi; Wills, Andrew; Du, Yiqin

2016-06-01

Intraocular pressure (IOP) is still the main treatment target for glaucoma. Outflow resistance mainly exists at the trabecular meshwork (TM) outflow pathway, which is responsible for IOP regulation. Changes of TM cellularity and TM extracellular matrix turnover may play important roles in IOP regulation. In this article, we review basic anatomy and physiology of the outflow pathway and TM stem cell characteristics regarding the location, isolation, identification and function. TM stem cells are localized at the insert region of the TM and are label-retaining in vivo. They can be isolated by side-population cell sorting, cloning culture, or sphere culture. TM stem cells are multipotent with the ability to home to the TM region and differentiate into TM cells in vivo. Other stem cell types, such as adipose-derived stem cells, mesenchymal stem cells and induced pluripotent stem cells have been discovered for TM cell differentiation and TM regeneration. We also review glaucomatous animal models, which are suitable to study stem cell-based therapies for TM regeneration.

Stem Cells in the Trabecular Meshwork for Regulating Intraocular Pressure

PubMed Central

Yun, Hongmin; Zhou, Yi; Wills, Andrew

2016-01-01

Abstract Intraocular pressure (IOP) is still the main treatment target for glaucoma. Outflow resistance mainly exists at the trabecular meshwork (TM) outflow pathway, which is responsible for IOP regulation. Changes of TM cellularity and TM extracellular matrix turnover may play important roles in IOP regulation. In this article, we review basic anatomy and physiology of the outflow pathway and TM stem cell characteristics regarding the location, isolation, identification and function. TM stem cells are localized at the insert region of the TM and are label-retaining in vivo. They can be isolated by side-population cell sorting, cloning culture, or sphere culture. TM stem cells are multipotent with the ability to home to the TM region and differentiate into TM cells in vivo. Other stem cell types, such as adipose-derived stem cells, mesenchymal stem cells and induced pluripotent stem cells have been discovered for TM cell differentiation and TM regeneration. We also review glaucomatous animal models, which are suitable to study stem cell-based therapies for TM regeneration. PMID:27183473

Effect and mode of action of the Texel muscling QTL (TM-QTL) on carcass traits in purebred Texel lambs.

PubMed

Macfarlane, J M; Lambe, N R; Matika, O; Johnson, P L; Wolf, B T; Haresign, W; Bishop, S C; Bünger, L

2014-07-01

TM-QTL is a quantitative trait locus (QTL) on ovine chromosome 18 (OAR18) known to affect loin muscling in Texel sheep. Previous work suggested that its mode of inheritance is consistent with paternal polar overdominance, but this has yet to be formally demonstrated. This study used purebred Texel sheep segregating for TM-QTL to confirm its presence in the chromosomal region in which it was first reported and to determine its pattern of inheritance. To do so, this study used the first available data from a Texel flock, which included homozygote TM-QTL carriers (TM/TM; n=34) in addition to homozygote non-carriers (+/+; n=40 and, heterozygote TM-QTL-carriers inheriting TM-QTL from their sire (TM/+; n=53) or their dam (+/TM; n=17). Phenotypes included a wide range of loin muscling, carcass composition and tissue distribution traits. The presence of a QTL affecting ultrasound muscle depth on OAR18 was confirmed with a paternal QTL effect ranging from +0.54 to +2.82 mm UMD (s.e. 0.37 to 0.57 mm) across the sires segregating for TM-QTL. Loin muscle width, depth and area, loin muscle volume and dissected M. longissimus lumborum weight were significantly greater for TM/+ than +/+ lambs (+2.9% to +7.9%; P<0.05). There was significant evidence that the effect of TM-QTL on the various loin muscling traits measured was paternally polar overdominant (P<0.05). In contrast, there was an additive effect of TM-QTL on both live weight at 20 weeks and carcass weight; TM/TM animals were significantly (P<0.05) heavier than +/+ (+11.1% and +7.3%, respectively) and +/TM animals (+11.9% and +11.7%, respectively), with TM/+ intermediate. Weights of the leg, saddle and shoulder region (corrected for carcass weight) were similar in the genotypic groups. There was a tendency for lambs inheriting TM-QTL from their sire to be less fat with slightly more muscle than non-carriers. For example, carcass muscle weight measured by live animal CT-scanning was 2.8% higher in TM/TM than +/+ lambs (P<0.05), carcass muscle weight measured by carcass CT-scanning was 1.36% higher in TM/+ than +/+ lambs (P<0.05), and weight of fat trimmed from the carcass cuts was significantly lower for TM/+ than +/+ lambs (-11.2%; P<0.05). No negative effects of TM-QTL on carcass traits were found. Optimal commercial use of TM-QTL within the sheep industry would require some consideration, due to the apparently different mode of action of the two main effects of TM-QTL (on growth and muscling).

Direct Simulation of Extinction in a Slab of Spherical Particles

NASA Technical Reports Server (NTRS)

Mackowski, D.W.; Mishchenko, Michael I.

2013-01-01

The exact multiple sphere superposition method is used to calculate the coherent and incoherent contributions to the ensemble-averaged electric field amplitude and Poynting vector in systems of randomly positioned nonabsorbing spherical particles. The target systems consist of cylindrical volumes, with radius several times larger than length, containing spheres with positional configurations generated by a Monte Carlo sampling method. Spatially dependent values for coherent electric field amplitude, coherent energy flux, and diffuse energy flux, are calculated by averaging of exact local field and flux values over multiple configurations and over spatially independent directions for fixed target geometry, sphere properties, and sphere volume fraction. Our results reveal exponential attenuation of the coherent field and the coherent energy flux inside the particulate layer and thereby further corroborate the general methodology of the microphysical radiative transfer theory. An effective medium model based on plane wave transmission and reflection by a plane layer is used to model the dependence of the coherent electric field on particle packing density. The effective attenuation coefficient of the random medium, computed from the direct simulations, is found to agree closely with effective medium theories and with measurements. In addition, the simulation results reveal the presence of a counter-propagating component to the coherent field, which arises due to the internal reflection of the main coherent field component by the target boundary. The characteristics of the diffuse flux are compared to, and found to be consistent with, a model based on the diffusion approximation of the radiative transfer theory.

Low temperature EPR investigation of Co2+ ion doped into rutile TiO2 single crystal: Experiments and simulations

NASA Astrophysics Data System (ADS)

Zerentürk, A.; Açıkgöz, M.; Kazan, S.; Yıldız, F.; Aktaş, B.

2017-02-01

In this paper, we present the results of X-band EPR spectra of Co2+ ion doped rutile (TiO2) which is one of the most promising memristor material. We obtained the angular variation of spectra in three mutually perpendicular planes at liquid helium (7-13 K) temperatures. Since the impurity ions have ½ effective spin and 7/2 nuclear spin, a relatively simple spin Hamiltonian containing only electronic Zeeman and hyperfine terms was utilized. Two different methods were used in theoretical analysis. Firstly, a linear regression analysis of spectra based on perturbation theory was studied. However, this approach is not sufficient for analyzing Co+2 spectra and leads to complex eigenvectors for G and A tensors due to large anisotropy of eigenvalues. Therefore, all spectra were analyzed again with exact diagonalization of spin Hamiltonian and the high accuracy eigenvalues and eigenvectors of G and A tensors were obtained by taking into account the effect of small sample misalignment from the exact crystallographic planes due to experimental conditions. Our results show that eigen-axes of g and A tensors are parallel to crystallographic directions. Hence, our EPR experiments proves that Co2+ ions substitute for Ti4+ ions in lattice. The obtained principal values of g tensor are gx=2.110(6), gy=5.890(2), gz=3.725(7) and principal values of hyperfine tensor are Ax=42.4, Ay=152.7, Az=26 (in 10-4/cm).

Forty-Year Calibrated Record of Earth-Surface Reflected Radiance from Landsat: A Review

NASA Technical Reports Server (NTRS)

Markham, Brian; Helder, Dennis

2011-01-01

Sensors on Landsat satellites have been collecting images of the Earth's surface for nearly 40 years. These images have been invaluable for characterizing and detecting changes in the land cover and land use of the world. Although initially conceived as primarily picture generating sensors, even the early sensors were radiometrically calibrated and spectrally characterized prior to launch and incorporated some capabilities to monitor their radiometric calibration once on orbit. Recently, as the focus of studies has shifted to monitoring Earth surface parameters over significant periods of time, serious attention has been focused toward bringing the data from all these sensors onto a common radiometric scale over this 40-year period. This effort started with the most recent systems and then was extended back in time. Landsat-7 ETM+, the best-characterized sensor of the series prior to launch and once on orbit, and the most stable system to date, was chosen to serve as the reference. The Landsat-7 project was the first of the series to build an image assessment system into its ground system, allowing systematic characterization of its sensors and data. Second, the Landsat-5 TM (still operating at the time of the Landsat-7 launch and continues to operate) calibration history was reconstructed based on its internal calibrator, vicarious calibrations, pseudo-invariant sites and a tie to Landsat-7 ETM+ at the time of the commissioning of Landsat-7. This process was performed in two iterations: the earlier one relied primarily on the TM internal calibrator. When this was found to have some deficiencies, a revised calibration was based more on pseudo-invariant sites, though the internal calibrator was still used to establish the short-term variations in response due to icing build up on the cold focal plane. As time progressed, a capability to monitor the Landsat-5 TM was added to the image assessment system. The Landsat-4 TM, which operated from 1982-1992, was the third system to which the radiometric scale was extended. The limited and broken use of the Landsat-4 TM made this analysis more difficult. Eight-day separated image pairs from Landsat-5 combined with analysis of pseudo invariant sites established this history. The fourth and most challenging effort was making the Landsat-1 to -5 MSS sensors' data internally radiometrically consistent. This effort was particularly complicated by the age of the MSS data, varying formats and processing levels in the archive, limited datasets, and limited documentation available. Ultimately, pseudo-invariant sites were identified in North America and used for this effort. Note that most of the Landsat-MSS archived data had already been calibrated using the MSS internal calibrators, so this processing was imbedded in the result. The final effort was developing an absolute scale for Landsat MSS similar to what was already established for the "TM" sensors. This was accomplished by using simultaneous data from Landsat-5 MSS and Landsat-5 TM, accounting for spectral differences between the sensors using EO-1 Hyperion data. The recalibrated history of the Landsat data and implications to users are discussed. The key result from this work is a consistently calibrated Landsat data archive that spans nearly 40 years with total uncertainties on the order of 10% or less for most sensors and bands.

Application of the ideas and techniques of classical fluid mechanics to some problems in physical oceanography.

PubMed

Johnson, R S

2018-01-28

This review makes a case for describing many of the flows observed in our oceans, simply based on the Euler equation, with (piecewise) constant density and with suitable boundary conditions. The analyses start from the Euler and mass conservation equations, expressed in a rotating, spherical coordinate system (but the f -plane and β -plane approximations are also mentioned); five examples are discussed. For three of them, a suitable non-dimensionalization is introduced, and a single small parameter is identified in each case. These three examples lead straightforwardly and directly to new results for: waves on the Pacific Equatorial Undercurrent (EUC) with a thermocline (in the f -plane); a nonlinear, three-dimensional model for EUC-type flows (in the β -plane); and a detailed model for large gyres. The other two examples are exact solutions of the complete system: a flow which corresponds to the underlying structure of the Pacific EUC; and a flow based on the necessary requirement to use a non-conservative body force, which produces the type of flow observed in the Antarctic Circumpolar Current. (All these examples have been discussed in detail in the references cited.) This review concludes with a few comments on how these solutions can be extended and expanded.This article is part of the theme issue 'Nonlinear water waves'. © 2017 The Author(s).

The interface character distribution of cold-rolled and annealed duplex stainless steel

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fang, Xiaoying, E-mail: fxy@sdut.edu.cn

The interface character distributions (ICDs) of cold-rolled and annealed duplex stainless steel specimens, previously solid-solution-heated (SHT) at 1573 K and 1323 K, are investigated using electron backscatter diffraction (EBSD) and five-parameter analysis (FPA). For the δ-ferrite phase, high concentrations of low angle grain boundaries (LAGBs) are developed, and the boundary planes are predominantly oriented on (111). High angle grain boundaries (HAGBs) with misorientations ranging from 50{sup o} to 60° are mostly pure tilt boundaries, and the boundary planes are primarily located on (112). For the austenite phase, very high density of coherent twin boundaries are introduced, implying that the boundarymore » planes are exactly oriented on (111). The phase boundary character distribution (PBPD) appears to be connected with the K-S and N-W orientation relationships (ORs) terminating on (110) {sub F}‖(111) {sub A} and (110){sub F}‖(hkl){sub A}, respectively. - Highlights: •Five-parameter analysis was used to determine interface character distribution. •ICD results of statistical meaning were achieved. •Initial microstructure has a significant effect on ICD. •Low and high angle GBs in δ phase prefer in (111) and (112) planes, respectively. •K-S phase boundaries terminate on (110){sub F}‖(111){sub A} while N-W ones on (110){sub F}‖(hkl){sub A}.« less

Phonon-interface scattering in multilayer graphene on an amorphous support

PubMed Central

Sadeghi, Mir Mohammad; Jo, Insun; Shi, Li

2013-01-01

The recent studies of thermal transport in suspended, supported, and encased graphene just began to uncover the richness of two-dimensional phonon physics, which is relevant to the performance and reliability of graphene-based functional materials and devices. Among the outstanding questions are the exact causes of the suppressed basal-plane thermal conductivity measured in graphene in contact with an amorphous material, and the layer thickness needed for supported or embedded multilayer graphene (MLG) to recover the high thermal conductivity of graphite. Here we use sensitive in-plane thermal transport measurements of graphene samples on amorphous silicon dioxide to show that full recovery to the thermal conductivity of the natural graphite source has yet to occur even after the MLG thickness is increased to 34 layers, considerably thicker than previously thought. This seemingly surprising finding is explained by long intrinsic scattering mean free paths of phonons in graphite along both basal-plane and cross-plane directions, as well as partially diffuse scattering of MLG phonons by the MLG-amorphous support interface, which is treated by an interface scattering model developed for highly anisotropic materials. Based on the phonon transmission coefficient calculated from reported experimental thermal interface conductance results, phonons emerging from the interface consist of a large component that is scattered across the interface, making rational choice of the support materials a potential approach to increasing the thermal conductivity of supported MLG. PMID:24067656

Multi-mode horn antenna simulation

NASA Technical Reports Server (NTRS)

Dod, L. R.; Wolf, J. D.

1980-01-01

Radiation patterns were computed for a circular multimode horn antenna using waveguide electric field radiation expressions. The circular multimode horn was considered as a possible reflector feed antenna for the Large Antenna Multifrequency Microwave Radiometer (LAMMR). This horn antenna uses a summation of the TE sub 11 deg and TM sub 11 deg modes to generate far field primary radiation patterns with equal E and H plane beamwidths and low sidelobes. A computer program for the radiation field expressions using the summation of waveguide radiation modes is described. The sensitivity of the multimode horn antenna radiation patterns to phase variations between the two modes is given. Sample radiation pattern calculations for a reflector feed horn for LAMMR are shown. The multimode horn antenna provides a low noise feed suitable for radiometric applications.

Sorting of tropomyosin isoforms in synchronised NIH 3T3 fibroblasts: evidence for distinct microfilament populations.

PubMed

Percival, J M; Thomas, G; Cock, T A; Gardiner, E M; Jeffrey, P L; Lin, J J; Weinberger, R P; Gunning, P

2000-11-01

The nonmuscle actin cytoskeleton consists of multiple networks of actin microfilaments. Many of these filament systems are bound by the actin-binding protein tropomyosin (Tm). We investigated whether Tm isoforms could be cell cycle regulated during G0 and G1 phases of the cell cycle in synchronised NIH 3T3 fibroblasts. Using Tm isoform-specific antibodies, we investigated protein expression levels of specific Tms in G0 and G1 phases and whether co-expressed isoforms could be sorted into different compartments. Protein levels of Tms 1, 2, 5a, 6, from the alpha Tm(fast) and beta-Tm genes increased approximately 2-fold during mid-late G1. Tm 3 levels did not change appreciably during G1 progression. In contrast, Tm 5NM gene isoform levels (Tm 5NM-1-11) increased 2-fold at 5 h into G1 and this increase was maintained for the following 3 h. However, Tm 5NM-1 and -2 levels decreased by a factor of three during this time. Comparison of the staining of the antibodies CG3 (detects all Tm 5NM gene products), WS5/9d (detects only two Tms from the Tm 5NM gene, Tm 5NM-1 and -2) and alpha(f)9d (detects specific Tms from the alpha Tm(fast) and beta-Tm genes) antibodies revealed 3 spatially distinct microfilament systems. Tm isoforms detected by alpha(f)9d were dramatically sorted from isoforms from the Tm 5NM gene detected by CG3. Tm 5NM-1 and Tm 5NM-2 were not incorporated into stress fibres, unlike other Tm 5NM isoforms, and marked a discrete, punctate, and highly polarised compartment in NIH 3T3 fibroblasts. All microfilament systems, excluding that detected by the WS5/9d antibody, were observed to coalign into parallel stress fibres at 8 h into G1. However, Tms detected by the CG3 and alpha(f)9d antibodies were incorporated into filaments at different times indicating distinct temporal control mechanisms. Microfilaments in NIH 3T3 cells containing Tm 5NM isoforms were more resistant to cytochalasin D-mediated actin depolymerisation than filaments containing isoforms from the alpha Tm(fast) and beta-Tm genes. This suggests that Tm 5NM isoforms may be in different microfilaments to alpha Tm(fast) and beta-Tm isoforms even when present in the same stress fibre. Staining of primary mouse fibroblasts showed identical Tm sorting patterns to those seen in cultured NIH 3T3 cells. Furthermore, we demonstrate that sorting of Tms is not restricted to cultured cells and can be observed in human columnar epithelial cells in vivo. We conclude that the expression and localisation of Tm isoforms are differentially regulated in G0 and G1 phase of the cell cycle. Tms mark multiple microfilament compartments with restricted tropomyosin composition. The creation of distinct microfilament compartments by differential sorting of Tm isoforms is observable in primary fibroblasts, cultured 3T3 cells and epithelial cells in vivo. Copyright 2000 Wiley-Liss, Inc.

Type II integral membrane protein, TM of J paramyxovirus promotes cell-to-cell fusion.

PubMed

Li, Zhuo; Hung, Cher; Paterson, Reay G; Michel, Frank; Fuentes, Sandra; Place, Ryan; Lin, Yuan; Hogan, Robert J; Lamb, Robert A; He, Biao

2015-10-06

Paramyxoviruses include many important animal and human pathogens. Most paramyxoviruses have two integral membrane proteins: fusion protein (F) and attachment proteins hemagglutinin, hemagglutinin-neuraminidase, or glycoprotein (G), which are critical for viral entry into cells. J paramyxovirus (JPV) encodes four integral membrane proteins: F, G, SH, and transmembrane (TM). The function of TM is not known. In this work, we have generated a viable JPV lacking TM (JPV∆TM). JPV∆TM formed opaque plaques compared with JPV. Quantitative syncytia assays showed that JPV∆TM was defective in promoting cell-to-cell fusion (i.e., syncytia formation) compared with JPV. Furthermore, cells separately expressing F, G, TM, or F plus G did not form syncytia whereas cells expressing F plus TM formed some syncytia. However, syncytia formation was much greater with coexpression of F, G, and TM. Biochemical analysis indicates that F, G, and TM interact with each other. A small hydrophobic region in the TM ectodomain from amino acid residues 118 to 132, the hydrophobic loop (HL), was important for syncytial promotion, suggesting that the TM HL region plays a critical role in cell-to-cell fusion.

A randomised controlled trial comparing TVT, Pelvicol and autologous fascial slings for the treatment of stress urinary incontinence in women.

PubMed

Guerrero, K L; Emery, S J; Wareham, K; Ismail, S; Watkins, A; Lucas, M G

2010-11-01

To compare TVT(TM) , Pelvicol(TM) and autologous fascial slings (AFSs). A multicentre randomised control trial. Four units in the UK. Women requiring primary surgery for stress urinary incontinence (SUI). A total of 201 women with urodynamically proven stress incontinence were randomised into three groups and assessed at baseline, 6 weeks, 6 months and 1 year. The primary outcome was patient-reported improvement rates. Secondary outcomes included operative complications/time, intermittent self-catheterisation (ISC) and re-operation rates. The quality-of-life tools used were the Bristol Female Lower Urinary Tract Symptoms (BFLUTS) and EuroQoL. Fifty women had a Pelvicol(TM) sling, 79 had AFSs and 72 had TVT(TM). At 6 months the Pelvicol(TM) arm had poorer improvement rates (73%) than TVT(TM) (92%)/AFS (95%); P=0.003. At 1 year only 61% of the Pelvicol(TM) slings remained as improved, versus 93% of TVTs and 90% of AFSs (P<0.001). Pelvicol(TM) has poorer dry rates (22%) than TVT(TM) (55%)/AFS (48%) (P=0.001) at 1 year; hence, the Pelvicol(TM) arm was suspended following interim analysis. There is no difference in the success rates between TVT(TM) and AFS. One in five women in the Pelvicol(TM) arm had further surgery for SUI by 1 year, but none required further surgery in the other arms. AFS took longer to do (54 minutes versus 35 minutes for TVT(TM) /36 minutes for Pelvicol(TM) ) and had higher ISC rates (9.9 versus 0% Pelvicol(TM) /TVT(TM) 1.5%). Hospital stay was shortest for TVT(TM) (2 days). Most BFLUTS domains showed improvement in all three arms. The improvement for women in the Pelvicol(TM) arm, however, was less than for women in the other arms in several key domains. Pelvicol(TM) cannot be recommended for the management of SUI. TVT(TM) does not have greater efficacy than AFS, but does utilise fewer resources. © 2010 The Authors Journal compilation © RCOG 2010 BJOG An International Journal of Obstetrics and Gynaecology.

Gold nanotube encapsulation enhanced magnetic properties of transition metal monoatomic chains: An ab initio study.

PubMed

Zhu, Liyan; Wang, Jinlan; Ding, Feng

2009-02-14

The magnetic properties of gold nanotubes encapsulated transition metal (TM, TM=Co and Mn) and monoatomic chains (TM@Au) are studied using first-principles density functional calculations. The TM chains are significantly stabilized by the gold nanotube coating. TM-TM distance-dependent ferromagnetic-antiferromagnetic phase transition in TM@Au is observed and can be understood by Ruderman-Kittel-Kasuya-Yosida (RKKY) model. The magnetocrystalline anisotropy energies of the TM@Au tubes are dramatically enhanced by one order of magnitude compared to those of free TM chains. Furthermore, the stronger interaction between Mn chain and gold nanotube even switches the easy magnetization axis along the tube.

Gold nanotube encapsulation enhanced magnetic properties of transition metal monoatomic chains: An ab initio study

NASA Astrophysics Data System (ADS)

Zhu, Liyan; Wang, Jinlan; Ding, Feng

2009-02-01

The magnetic properties of gold nanotubes encapsulated transition metal (TM, TM=Co and Mn) and monoatomic chains (TM@Au) are studied using first-principles density functional calculations. The TM chains are significantly stabilized by the gold nanotube coating. TM-TM distance-dependent ferromagnetic-antiferromagnetic phase transition in TM@Au is observed and can be understood by Ruderman-Kittel-Kasuya-Yosida (RKKY) model. The magnetocrystalline anisotropy energies of the TM@Au tubes are dramatically enhanced by one order of magnitude compared to those of free TM chains. Furthermore, the stronger interaction between Mn chain and gold nanotube even switches the easy magnetization axis along the tube.

Effects of source of trace minerals and plane of nutrition on growth and health of transported neonatal dairy calves.

PubMed

Osorio, J S; Wallace, R L; Tomlinson, D J; Earleywine, T J; Socha, M T; Drackley, J K

2012-10-01

The aims of the experiment were to evaluate the effects of source of trace minerals (TM) and plane of nutrition (PN) early in life on growth and health of transported calves. Ninety male Holstein calves <1 wk old were assigned to treatments in a 2×2 factorial arrangement of PN and TM source in a randomized complete block design. Calves assigned to low PN (LPN) received milk replacer [22% crude protein (CP), 20% fat, 568 g of powder/d for wk 1 to 4, and 284 g of powder/d for wk 5] plus ad libitum access to starter [18% CP, dry matter (DM) basis, for wk 1 to 12] and a limited amount of hay (0.5 kg/d as fed, for wk 10 to 12); LPN calves were weaned at 6 wk. During wk 13 to 20, LPN calves were fed 3.2 kg/d of grower mix (16% CP, DM basis) plus chopped hay for ad libitum intake. Calves assigned to high PN (HPN) received variable amounts of milk replacer (28% CP; 20% fat; and 810, 1,136, and 568 g of powder/d for wk 1, 2 to 6, and 7, respectively) plus ad libitum access to starter (22% CP, DM basis, wk 1 to 12) and limited hay (0.5 kg/d as fed, for wk 10 to 12); HPN calves were weaned at wk 7. Calves assigned to HPN were offered grower mix for ad libitum intake plus a limited amount of chopped hay (0.5 kg/d, as-fed basis) from wk 13 to 20. Milk replacers were formulated to contain balanced amounts of either inorganic (I) or organic (O) TM (50, 50, 10, and 100mg/kg of Zn, Mn, Cu, and Fe, respectively), whereas respective ITM or OTM starters and growers contained Zn, Mn, Cu, and Co at 70, 55, 12, and 1mg/kg. The HPN treatments increased final body weight and stature measurements, average daily gain, and gain-to-feed ratio through wk 20. Starter intake was lower for calves fed HPN. The OTM increased growth when supplemented to HPN but not when supplemented to LPN. During the liquid-feeding period, fecal scores were more fluid for calves fed HPN but measures of health status did not differ among diets. Results indicated that an enhanced nutritional program during early life allowed calves to have greater overall growth and maintain a normal health status throughout the preweaning period. High PN and OTM were synergistic in increasing early growth of calves. Copyright © 2012 American Dairy Science Association. Published by Elsevier Inc. All rights reserved.

Cytoskeletal tropomyosin Tm5NM1 is required for normal excitation-contraction coupling in skeletal muscle.

PubMed

Vlahovich, Nicole; Kee, Anthony J; Van der Poel, Chris; Kettle, Emma; Hernandez-Deviez, Delia; Lucas, Christine; Lynch, Gordon S; Parton, Robert G; Gunning, Peter W; Hardeman, Edna C

2009-01-01

The functional diversity of the actin microfilaments relies in part on the actin binding protein tropomyosin (Tm). The muscle-specific Tms regulate actin-myosin interactions and hence contraction. However, there is less known about the roles of the numerous cytoskeletal isoforms. We have shown previously that a cytoskeletal Tm, Tm5NM1, defines a Z-line adjacent cytoskeleton in skeletal muscle. Recently, we identified a second cytoskeletal Tm in this region, Tm4. Here we show that Tm4 and Tm5NM1 define separate actin filaments; the former associated with the terminal sarcoplasmic reticulum (SR) and other tubulovesicular structures. In skeletal muscles of Tm5NM1 knockout (KO) mice, Tm4 localization was unchanged, demonstrating the specificity of the membrane association. Tm5NM1 KO muscles exhibit potentiation of T-system depolarization and decreased force rundown with repeated T-tubule depolarizations consistent with altered T-tubule function. These results indicate that a Tm5NM1-defined actin cytoskeleton is required for the normal excitation-contraction coupling in skeletal muscle.

Cytoskeletal Tropomyosin Tm5NM1 Is Required for Normal Excitation–Contraction Coupling in Skeletal Muscle

PubMed Central

Vlahovich, Nicole; Kee, Anthony J.; Van der Poel, Chris; Kettle, Emma; Hernandez-Deviez, Delia; Lucas, Christine; Lynch, Gordon S.; Parton, Robert G.; Gunning, Peter W.

2009-01-01

The functional diversity of the actin microfilaments relies in part on the actin binding protein tropomyosin (Tm). The muscle-specific Tms regulate actin-myosin interactions and hence contraction. However, there is less known about the roles of the numerous cytoskeletal isoforms. We have shown previously that a cytoskeletal Tm, Tm5NM1, defines a Z-line adjacent cytoskeleton in skeletal muscle. Recently, we identified a second cytoskeletal Tm in this region, Tm4. Here we show that Tm4 and Tm5NM1 define separate actin filaments; the former associated with the terminal sarcoplasmic reticulum (SR) and other tubulovesicular structures. In skeletal muscles of Tm5NM1 knockout (KO) mice, Tm4 localization was unchanged, demonstrating the specificity of the membrane association. Tm5NM1 KO muscles exhibit potentiation of T-system depolarization and decreased force rundown with repeated T-tubule depolarizations consistent with altered T-tubule function. These results indicate that a Tm5NM1-defined actin cytoskeleton is required for the normal excitation–contraction coupling in skeletal muscle. PMID:19005216

Hypolipidemic activity of Taraxacum mongolicum associated with the activation of AMP-activated protein kinase in human HepG2 cells.

PubMed

Liu, Yan-Jin; Shieh, Po-Chuen; Lee, Jang-Chang; Chen, Fu-An; Lee, Chih-Hung; Kuo, Sheng-Chu; Ho, Chi-Tang; Kuo, Daih-Huang; Huang, Li-Jiau; Way, Tzong-Der

2014-08-01

This study investigated the hypolipidemic effect and potential mechanisms of T. mongolicum extracts. T. mongolicum was extracted by refluxing three times with water (TM-1), 50% ethanol (TM-2) and 95% ethanol (TM-3). TM-2 contained components with the most effective hypolipidemic potentials in HepG2 cells. Extended administration of TM-2 stimulated a significant reduction in body weight and levels of serum triglyceride LDL-C and total cholesterol in rats. To evaluate the bioactive compounds, we successively fractionated TM-2 with n-hexane (TM-4), dichloromethane (TM-5), ethyl acetate (TM-6), and water (TM-7). TM-4 fraction had the most effective hypolipidemic potential in HepG2 cells, and it decreased the expression of fatty acid synthase (FASN) and inhibited the activity of acetyl-coenzyme A carboxylase (ACC) through the phosphorylation of AMP-activated protein kinase (AMPK). Linoleic acid, phytol and tetracosanol are bioactive compounds identified from TM-4. These results suggest that T. mongolicum is expected to be useful for hypolipidemic effects.

Structure of a Double Transmembrane Fragment of a G-Protein-Coupled Receptor in Micelles

PubMed Central

Neumoin, Alexey; Cohen, Leah S.; Arshava, Boris; Tantry, Subramanyam; Becker, Jeffrey M.; Zerbe, Oliver; Naider, Fred

2009-01-01

Abstract The structure and dynamic properties of an 80-residue fragment of Ste2p, the G-protein-coupled receptor for α-factor of Saccharomyces cerevisiae, was studied in LPPG micelles with the use of solution NMR spectroscopy. The fragment Ste2p(G31-T110) (TM1-TM2) consisted of 19 residues from the N-terminal domain, the first TM helix (TM1), the first cytoplasmic loop, the second TM helix (TM2), and seven residues from the first extracellular loop. Multidimensional NMR experiments on [15N], [15N, 13C], [15N, 13C, 2H]-labeled TM1-TM2 and on protein fragments selectively labeled at specific amino acid residues or protonated at selected methyl groups resulted in >95% assignment of backbone and side-chain nuclei. The NMR investigation revealed the secondary structure of specific residues of TM1-TM2. TALOS constraints and NOE connectivities were used to calculate a structure for TM1-TM2 that was highlighted by the presence of three α-helices encompassing residues 39–47, 49–72, and 80–103, with higher flexibility around the internal Arg58 site of TM1. RMSD values of individually superimposed helical segments 39–47, 49–72, and 80–103 were 0.25 ± 0.10 Å, 0.40 ± 0.13 Å, and 0.57 ± 0.19 Å, respectively. Several long-range interhelical connectivities supported the folding of TM1-TM2 into a tertiary structure typified by a crossed helix that splays apart toward the extracellular regions and contains considerable flexibility in the G56VRSG60 region. 15N-relaxation and hydrogen-deuterium exchange data support a stable fold for the TM parts of TM1-TM2, whereas the solvent-exposed segments are more flexible. The NMR structure is consistent with the results of biochemical experiments that identified the ligand-binding site within this region of the receptor. PMID:19383463

NMR Investigation of Structures of G-protein Coupled Receptor Folding Intermediates*

PubMed Central

Poms, Martin; Ansorge, Philipp; Martinez-Gil, Luis; Jurt, Simon; Gottstein, Daniel; Fracchiolla, Katrina E.; Cohen, Leah S.; Güntert, Peter; Mingarro, Ismael; Naider, Fred; Zerbe, Oliver

2016-01-01

Folding of G-protein coupled receptors (GPCRs) according to the two-stage model (Popot, J. L., and Engelman, D. M. (1990) Biochemistry 29, 4031–4037) is postulated to proceed in 2 steps: partitioning of the polypeptide into the membrane followed by diffusion until native contacts are formed. Herein we investigate conformational preferences of fragments of the yeast Ste2p receptor using NMR. Constructs comprising the first, the first two, and the first three transmembrane (TM) segments, as well as a construct comprising TM1–TM2 covalently linked to TM7 were examined. We observed that the isolated TM1 does not form a stable helix nor does it integrate well into the micelle. TM1 is significantly stabilized upon interaction with TM2, forming a helical hairpin reported previously (Neumoin, A., Cohen, L. S., Arshava, B., Tantry, S., Becker, J. M., Zerbe, O., and Naider, F. (2009) Biophys. J. 96, 3187–3196), and in this case the protein integrates into the hydrophobic interior of the micelle. TM123 displays a strong tendency to oligomerize, but hydrogen exchange data reveal that the center of TM3 is solvent exposed. In all GPCRs so-far structurally characterized TM7 forms many contacts with TM1 and TM2. In our study TM127 integrates well into the hydrophobic environment, but TM7 does not stably pack against the remaining helices. Topology mapping in microsomal membranes also indicates that TM1 does not integrate in a membrane-spanning fashion, but that TM12, TM123, and TM127 adopt predominantly native-like topologies. The data from our study would be consistent with the retention of individual helices of incompletely synthesized GPCRs in the vicinity of the translocon until the complete receptor is released into the membrane interior. PMID:27864365

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yang, Hao; Lee, H. S.; Sarahan, M. C.

Grain boundaries (GBs) in complex oxides such as perovskites have been shown to readily accommodate nonstoichiometry changing the electrostatic potential at the boundary plane and effectively controlling material properties such as capacitance, magnetoresistance and superconductivity. Understanding and quantifying exactly how variations in atomic scale nonstoichiometry at the boundary plane extend to the practical mesoscale operating length of the system is therefore critical for improving the overall properties. Bicrystals of SrTiO 3 were fabricated to provide the model GB model structures that are analysed in this paper. We show that statistical analysis of aberration-corrected scanning transmission electron microscope images acquired frommore » a large area of GB is an effective routine to understanding the variation in boundary structure that occurs to accommodate nonstoichiometry. In the case of the SrTiO 3 22.6° Σ13 (510)/[100] GB analysed here, the symmetric atomic structures observed from a micron-long GB can be categorized as two different competing structural arrangements, with and without a rigid-body translation along the boundary plane. How this quantified experimental approach can provide direct insights into the GB energetics is further confirmed from the first principles density functional theory, and the effect of nonstoichiometry in determining the GB energies is quantified.« less

Slope angle estimation method based on sparse subspace clustering for probe safe landing

NASA Astrophysics Data System (ADS)

Li, Haibo; Cao, Yunfeng; Ding, Meng; Zhuang, Likui

2018-06-01

To avoid planetary probes landing on steep slopes where they may slip or tip over, a new method of slope angle estimation based on sparse subspace clustering is proposed to improve accuracy. First, a coordinate system is defined and established to describe the measured data of light detection and ranging (LIDAR). Second, this data is processed and expressed with a sparse representation. Third, on this basis, the data is made to cluster to determine which subspace it belongs to. Fourth, eliminating outliers in subspace, the correct data points are used for the fitting planes. Finally, the vectors normal to the planes are obtained using the plane model, and the angle between the normal vectors is obtained through calculation. Based on the geometric relationship, this angle is equal in value to the slope angle. The proposed method was tested in a series of experiments. The experimental results show that this method can effectively estimate the slope angle, can overcome the influence of noise and obtain an exact slope angle. Compared with other methods, this method can minimize the measuring errors and further improve the estimation accuracy of the slope angle.

The propagation of the shock wave from a strong explosion in a plane-parallel stratified medium: the Kompaneets approximation

NASA Astrophysics Data System (ADS)

Olano, C. A.

2009-11-01

Context: Using certain simplifications, Kompaneets derived a partial differential equation that states the local geometrical and kinematical conditions that each surface element of a shock wave, created by a point blast in a stratified gaseous medium, must satisfy. Kompaneets could solve his equation analytically for the case of a wave propagating in an exponentially stratified medium, obtaining the form of the shock front at progressive evolutionary stages. Complete analytical solutions of the Kompaneets equation for shock wave motion in further plane-parallel stratified media were not found, except for radially stratified media. Aims: We aim to analytically solve the Kompaneets equation for the motion of a shock wave in different plane-parallel stratified media that can reflect a wide variety of astrophysical contexts. We were particularly interested in solving the Kompaneets equation for a strong explosion in the interstellar medium of the Galactic disk, in which, due to intense winds and explosions of stars, gigantic gaseous structures known as superbubbles and supershells are formed. Methods: Using the Kompaneets approximation, we derived a pair of equations that we call adapted Kompaneets equations, that govern the propagation of a shock wave in a stratified medium and that permit us to obtain solutions in parametric form. The solutions provided by the system of adapted Kompaneets equations are equivalent to those of the Kompaneets equation. We solved the adapted Kompaneets equations for shock wave propagation in a generic stratified medium by means of a power-series method. Results: Using the series solution for a shock wave in a generic medium, we obtained the series solutions for four specific media whose respective density distributions in the direction perpendicular to the stratification plane are of an exponential, power-law type (one with exponent k=-1 and the other with k =-2) and a quadratic hyperbolic-secant. From these series solutions, we deduced exact solutions for the four media in terms of elemental functions. The exact solution for shock wave propagation in a medium of quadratic hyperbolic-secant density distribution is very appropriate to describe the growth of superbubbles in the Galactic disk. Member of the Carrera del Investigador Científico del CONICET, Argentina.

Evaluation of Thematic Mapper data for mapping forest, agricultural and soil resources

NASA Technical Reports Server (NTRS)

Degloria, S.; Benson, A.; Dummer, K.; Fakhoury, E.

1985-01-01

Color composite TM film products which include TM5, TM4, and a visible band (TM1, TM2, or TM3) are superior to composites which exclude TM4 for discriminating most forest and agricultural cover types and estimating area proportions for inventory and sampling purposes. Clustering a subset of TM data results in a spectral class map which groups diverse forest cover types into spectrally and ecologically similar areas suitable for use as a stratification base in traditional forest inventory practices. Analysis of simulated Thematic Mapper data indicate that the location and number of TM spectral bands are suitable for detecting differences in major soil properties and characterizing soil spectral curve form and magnitude.

TM4SF5 promotes metastatic behavior of cells in 3D extracellular matrix gels by reducing dependency on environmental cues

PubMed Central

Nam, Seo Hee; Cheong, Jin-Gyu; Jeong, Doyoung; Lee, Seo-Jin; Pan, Cheol-Ho; Jung, Jae Woo; Kim, Hye-Jin; Ryu, Jihye; Kim, Ji Eon; Kim, Somi; Cho, Chang Yun; Kang, Min-Kyung; Lee, Kyung-Min; Lee, Jung Weon

2017-01-01

Transmembrane 4 L six family member 5 (TM4SF5) is highly expressed in hepatocellular carcinoma tissues and enhances migration in two-dimensional environments. Here, we investigated how TM4SF5 is involved in diverse pro-metastatic phenotypes in in vivo-like three-dimensional (3D) extracellular matrix gels. TM4SF5-positive cells aggressively formed invasive foci in 3D Matrigel, depending on TM4SF5-mediated signaling activity, cytoskeletal organization, and matrix metallopeptidase (MMP) 2-mediated extracellular remodeling, whereas TM4SF5-null cells did not. The TM4SF5-null cells did, however, form invasive foci in 3D Matrigel following inhibition of Rho-associated protein kinase or addition of collagen I, suggesting that collagen I compensated for TM4SF5 expression. Similarly, TM4SF5-positive cells expressing vascular endothelial-cadherin formed network-like vasculogenic mimicry in 3D Matrigel and collagen I mixture gels, whereas TM4SF5-negative cells in the mixture gels displayed the network structures only upon further treatment with epidermal growth factor. The foci formation also required MMP2-mediated remodeling of the extracellular matrix. Co-cultures exhibited TM4SF5-positive or cancer-associated fibroblasts at the outward edges of TM4SF5-null cell clusters. Compared with TM4SF5-null cells, TM4SF5-positive cells in 3D collagen gels showed a more invasive outgrowth with dramatic invadopodia. These observations suggest that TM4SF5 plays roles in the promotion of diverse metastatic properties with fewer environmental requirements than TM4SF5-negative cells. PMID:29137358

Depletion of autophagy-related genes ATG3 and ATG5 in Tenebrio molitor leads to decreased survivability against an intracellular pathogen, Listeria monocytogenes.

PubMed

Tindwa, Hamisi; Jo, Yong Hun; Patnaik, Bharat Bhusan; Noh, Mi Young; Kim, Dong Hyun; Kim, Iksoo; Han, Yeon Soo; Lee, Yong Seok; Lee, Bok Luel; Kim, Nam Jung

2015-01-01

Macroautophagy (autophagy) is an evolutionarily conserved catabolic process involved in physiological and developmental processes including cell survival, death, and innate immunity. Homologues of most of 36 originally discovered autophagy-related (ATG) genes in yeast have been characterized in higher eukaryotes including insects. In this study, the homologues of ATG3 (TmATG3) and ATG5 (TmATG5) were isolated from the coleopteran beetle, Tenebrio molitor by expressed sequence tag and RNAseq approaches. The cDNA of TmATG3 and TmATG5 comprise open-reading frame sizes of 963 and 792 bp encoding polypeptides of 320 and 263 amino acid residues, respectively. TmATG3 and TmATG5 mRNA are expressed in all developmental stages, and mainly in fat body and hemocytes of larvae. TmATG3 and TmATG5 showed an overall sequence identity of 58-95% to other insect Atg proteins. There exist clear one-to-one orthologs of TmATG3 and TmATG5 in Tribolium and that they clustered together in the gene tree. Depletion of TmATG3 and TmATG5 by RNA interference led to a significant reduction in survival ability of T. molitor larvae against an intracellular pathogen, Listeria monocytogenes. Six days post-Listeria challenge, the survival rate in the dsEGFP-injected (where EGFP is enhanced green fluorescent protein) control larvae was significantly higher (55%) compared to 4 and 3% for TmATG3 and TmATG5 double-stranded RNA injected larvae, respectively. These data suggested that TmATG3 and TmATG5 may play putative role in mediating autophagy-based clearance of Listeria in T. molitor model. © 2014 Wiley Periodicals, Inc.

Longitudinal spread of mechanical excitation through tectorial membrane traveling waves

PubMed Central

Sellon, Jonathan B.; Farrahi, Shirin; Ghaffari, Roozbeh; Freeman, Dennis M.

2015-01-01

The mammalian inner ear separates sounds by their frequency content, and this separation underlies important properties of human hearing, including our ability to understand speech in noisy environments. Studies of genetic disorders of hearing have demonstrated a link between frequency selectivity and wave properties of the tectorial membrane (TM). To understand these wave properties better, we developed chemical manipulations that systematically and reversibly alter TM stiffness and viscosity. Using microfabricated shear probes, we show that (i) reducing pH reduces TM stiffness with little change in TM viscosity and (ii) adding PEG increases TM viscosity with little change in TM stiffness. By applying these manipulations in measurements of TM waves, we show that TM wave speed is determined primarily by stiffness at low frequencies and by viscosity at high frequencies. Both TM viscosity and stiffness affect the longitudinal spread of mechanical excitation through the TM over a broad range of frequencies. Increasing TM viscosity or decreasing stiffness reduces longitudinal spread of mechanical excitation, thereby coupling a smaller range of best frequencies and sharpening tuning. In contrast, increasing viscous loss or decreasing stiffness would tend to broaden tuning in resonance-based TM models. Thus, TM wave and resonance mechanisms are fundamentally different in the way they control frequency selectivity. PMID:26438861

Modeling Cr-to-Tm and Cr-to-Tm-to-Ho energy transfer in YAG crystals

NASA Technical Reports Server (NTRS)

Swetits, John J.

1991-01-01

A systematic analysis of energy transfer processes in crystals of YAG doped with varying concentrations of Cr and Tm is described. Both spectral measurements and measurements of the temporal response to pulsed excitation are used to give independent determinations of the microscopic interaction parameter for Cr to Tm transfer. The different factors in influencing the temperature dependence of the Cr to Tm transfer are discussed. The dependence of the Tm cross-relaxation rate on Tm concentration is determined.

Operating Policies for Non- stationary Two-Echelon Inventory Systems for Reparable Items.

DTIC Science & Technology

1986-05-01

resupply policy. Even under an HCP, we might want to change the resupply policy at management igtervention times to reflect what we predict will happen...management is concerned with the worst performance predicted during the horizon. Regardless of the average performance over the horizon, management may not...locations in DCi(tm-ll tm ) and INi(tm-l tm) . Case 3 a: ASi(tm I ) > ASi(tm); INi(tm- lstm ) empty. Disposals must be made to lover the asset positions

Secondary Fracturing of Europa's Crust in Response to Combined Slip and Dilation Along Strike-Slip Faults

NASA Technical Reports Server (NTRS)

Kattenhorn, S. A.

2003-01-01

A commonly observed feature in faulted terrestrial rocks is the occurrence of secondary fractures alongside faults. Depending on exact morphology, such fractures have been termed tail cracks, wing cracks, kinks, or horsetail fractures, and typically form at the tip of a slipping fault or around small jogs or steps along a fault surface. The location and orientation of secondary fracturing with respect to the fault plane or the fault tip can be used to determine if fault motion is left-lateral or right-lateral.

Toward a structural understanding of turbulent drag reduction: nonlinear coherent states in viscoelastic shear flows.

PubMed

Stone, Philip A; Waleffe, Fabian; Graham, Michael D

2002-11-11

Nontrivial steady flows have recently been found that capture the main structures of the turbulent buffer layer. We study the effects of polymer addition on these "exact coherent states" (ECS) in plane Couette flow. Despite the simplicity of the ECS flows, these effects closely mirror those observed experimentally: Structures shift to larger length scales, wall-normal fluctuations are suppressed while streamwise ones are enhanced, and drag is reduced. The mechanism underlying these effects is elucidated. These results suggest that the ECS are closely related to buffer layer turbulence.

Time's arrow: A numerical experiment

NASA Astrophysics Data System (ADS)

Fowles, G. Richard

1994-04-01

The dependence of time's arrow on initial conditions is illustrated by a numerical example in which plane waves produced by an initial pressure pulse are followed as they are multiply reflected at internal interfaces of a layered medium. Wave interactions at interfaces are shown to be analogous to the retarded and advanced waves of point sources. The model is linear and the calculation is exact and demonstrably time reversible; nevertheless the results show most of the features expected of a macroscopically irreversible system, including the approach to the Maxwell-Boltzmann distribution, ergodicity, and concomitant entropy increase.

Aerospace plane guidance using geometric control theory

NASA Technical Reports Server (NTRS)

Van Buren, Mark A.; Mease, Kenneth D.

1990-01-01

A reduced-order method employing decomposition, based on time-scale separation, of the 4-D state space in a 2-D slow manifold and a family of 2-D fast manifolds is shown to provide an excellent approximation to the full-order minimum-fuel ascent trajectory. Near-optimal guidance is obtained by tracking the reduced-order trajectory. The tracking problem is solved as regulation problems on the family of fast manifolds, using the exact linearization methodology from nonlinear geometric control theory. The validity of the overall guidance approach is indicated by simulation.

Steiner trees and spanning trees in six-pin soap films

NASA Astrophysics Data System (ADS)

Dutta, Prasun; Khastgir, S. Pratik; Roy, Anushree

2010-02-01

The problem of finding minimum (local as well as absolute) path lengths joining given points (or terminals) on a plane is known as the Steiner problem. The Steiner problem arises in finding the minimum total road length joining several towns and cities. We study the Steiner tree problem using six-pin soap films. Experimentally, we observe spanning trees as well as Steiner trees partly by varying the pin diameter. We propose a possibly exact expression for the length of a spanning tree or a Steiner tree, which fails mysteriously in certain cases.

Justification and refinement of Winkler–Fuss hypothesis

NASA Astrophysics Data System (ADS)

Kaplunov, J.; Prikazchikov, D.; Sultanova, L.

2018-06-01

Two-parametric asymptotic analysis of the equilibrium of an elastic half-space coated by a thin soft layer is developed. The initial scaling is motivated by the exact solution of the plane problem for a vertical harmonic load. It is established that the Winkler-Fuss hypothesis is valid only for a sufficiently high contrast in the stiffnesses of the layer and the half-space. As an alternative, a uniformly valid non-local approximation is proposed. Higher-order corrections to the Winkler-Fuss formulation, such as the Pasternak model, are also studied.

The Effect of Transcendental Meditation on Language Learning and GPA.

ERIC Educational Resources Information Center

Dodds, Dinah; And Others

An experiment was carried out at Lewis and Clark College to measure the effect of Transcendental Meditation (TM) on learning German. Three sections of first-year German were formed into a TM group, a TM-like group, and a control group. The TM group received training in TM given by two trained, experienced teachers. The TM-like section received…

Probing structure, thermochemistry, electron affinity, and magnetic moment of thulium-doped silicon clusters TmSi n (n = 3-10) and their anions with density functional theory.

PubMed

Huang, Xintao; Yang, Jucai

2017-12-26

The most stable structures and electronic properties of TmSi n (n = 3-10) clusters and their anions have been probed by using the ABCluster global search technique combined with the PBE, TPSSh, and B3LYP density functional methods. The results revealed that the most stable structures of neutral TmSi n and their anions can be regarded as substituting a Si atom of the ground state structure of Si n + 1 with a Tm atom. The reliable AEAs, VDEs and simulated PES of TmSi n (n = 3-10) are presented. Calculations of HOMO-LUMO gap revealed that introducing Tm atom to Si cluster can improve photochemical reactivity of the cluster. The NPA analyses indicated that the 4f electron of Tm atom in TmSi n (n = 3-10) and their anions do not participate in bonding. The total magnetic moments of TmSi n are mainly provided by the 4f electrons of Tm atom. The dissociation energy of Tm atom from the most stable structure of TmSi n and their anions has been calculated to examine relative stability.

Comparative study of high power Tm:YLF and Tm:LLF slab lasers in continuous wave regime.

PubMed

Berrou, Antoine; Collett, Oliver J P; Morris, Daniel; Esser, M J Daniel

2018-04-16

We report on Tm:YLF and Tm:LLF slab lasers (1.5 x 11 x 20 mm 3 ) end pumped from one end with a high-brightness 792 nm laser diode stack. These two lasers are compared under identical pump conditions in continuous-wave regime. A stronger negative thermal lens in Tm:LLF than in Tm:YLF is highlighted, making it more difficult to operate the Tm:LLF laser under stable lasing conditions. In a configuration where the high reflectivity cavity mirror has a radius of curvature of r = 150 mm, the Tm:YLF (Tm:LLF) laser produces a maximum output power of 150 W (143 W) for 428 W of incident pump power (respectively). For a second cavity configuration where the high reflectivity cavity mirror has a radius of curvature of r = 500 mm, the Tm:YLF laser produces a maximum output power of 164 W for 412 W of incident pump power and a 57% slope efficiency with respect to the absorbed pump power. The emitted wavelength of these two lasers are measured as a function of the output coupler reflectivity and it shows that Tm:LLF laser emits at a longer wavelength than Tm:YLF.

Molecular characterization of novel mucosotropic papillomaviruses from a Florida manatee (Trichechus manatus latirostris).

PubMed

2015-12-01

We isolated two new manatee papillomavirus (PV) types, TmPV3 and TmPV4, from a Florida manatee (Trichechus manatus latirostris). Two PV types were previously isolated from this species. TmPV1 is widely dispersed amongst manatees and a close-to-root PV; not much is known about TmPV2. The genomes of TmPV3 and TmPV4 were 7622 and 7771 bp in size, respectively. Both PVs had a genomic organization characteristic of all PVs, with one non-coding region and seven ORFs, including the E7 ORF that is absent in other cetacean PVs. Although these PVs were isolated from separate genital lesions of the same manatee, an enlarged E2/E4 ORF was found only in the TmPV4 genome. The full genome and L1 sequence similarities between TmPV3 and TmPV4 were 63.2 and 70.3 %, respectively. These genomes shared only 49.1 and 50.2 % similarity with TmPV1. The pairwise alignment of L1 nucleotide sequences indicated that the two new PVs nested in a monophyletic group of the genus Rhopapillomavirus, together with the cutaneotropic TmPV1 and TmPV2.

Comparative study of optical and scintillation properties of Tm3+:YAG, and Tm3+:LuAG single crystals

NASA Astrophysics Data System (ADS)

Fujimoto, Yutaka; Sugiyama, Makoto; Yanagida, Takayuki; Wakahara, Shingo; Suzuki, Shotaro; Kurosawa, Shunsuke; Chani, Valery; Yoshikawa, Akira

2013-09-01

The optical and scintillation properties of Tm3+-doped yttrium aluminum garnet Y3Al5O12 (YAG) and Tm3+-doped lutetium aluminum garnet Lu3Al5O12 (LuAG) are compared. The Tm3+-doped single crystals were grown by the micro-pulling down (μ-PD) technique. Both crystals demonstrated some emission peaks originated from 4f-4f forbidden transition of Tm3+ under 241Am alpha-ray excitation. The scintillation decay time of Tm3+-doped YAG was similar to that of LuAG. When irradiated by the gamma-rays from a 137Cs source, the relative scintillation light yields of Tm:YAG was 90% greater than that of Tm:LuAG.

Three-dimensional instability of standing waves

NASA Astrophysics Data System (ADS)

Zhu, Qiang; Liu, Yuming; Yue, Dick K. P.

2003-12-01

We investigate the three-dimensional instability of finite-amplitude standing surface waves under the influence of gravity. The analysis employs the transition matrix (TM) approach and uses a new high-order spectral element (HOSE) method for computation of the nonlinear wave dynamics. HOSE is an extension of the original high-order spectral method (HOS) wherein nonlinear wave wave and wave body interactions are retained up to high order in wave steepness. Instead of global basis functions in HOS, however, HOSE employs spectral elements to allow for complex free-surface geometries and surface-piercing bodies. Exponential convergence of HOS with respect to the total number of spectral modes (for a fixed number of elements) and interaction order is retained in HOSE. In this study, we use TM-HOSE to obtain the stability of general three-dimensional perturbations (on a two-dimensional surface) on two classes of standing waves: plane standing waves in a rectangular tank; and radial/azimuthal standing waves in a circular basin. For plane standing waves, we confirm the known result of two-dimensional side-bandlike instability. In addition, we find a novel three-dimensional instability for base flow of any amplitude. The dominant component of the unstable disturbance is an oblique (standing) wave oriented at an arbitrary angle whose frequency is close to the (nonlinear) frequency of the original standing wave. This finding is confirmed by direct long-time simulations using HOSE which show that the nonlinear evolution leads to classical Fermi Pasta Ulam recurrence. For the circular basin, we find that, beyond a threshold wave steepness, a standing wave (of nonlinear frequency Omega) is unstable to three-dimensional perturbations. The unstable perturbation contains two dominant (standing-wave) components, the sum of whose frequencies is close to 2Omega. From the cases we consider, the critical wave steepness is found to generally decrease/increase with increasing radial/azimuthal mode number of the base standing wave. Finally, we show that the instability we find for both two- and three-dimensional standing waves is a result of third-order (quartet) resonance.

Effect of leaf variables on visible, near-infrared and mid-infrared reflectance of excised leaves

NASA Technical Reports Server (NTRS)

Bell, R.; Labovitz, M. L.; Ludwig, R. W.

1983-01-01

Effects of an imposed (excised) leaf orientation, differing species and differing venation patterns on reflectance measurements in the LANDSAT-4 thematic mapper (TM) channels TM3 (0.63 to 0.69 microns), TM4 (0.76 to 0.90 microns), and TM5 (1.55 to 1.75 microns) were investigated. Orientation of leaves (random vs. systematic placement) was found to affect measurements in the TM4 channel, but not the TM3 and TM5 measurements. Venation caused no significant changes for any band. Azimuth of incident radiation was not a significant main effect, but in conjunction with changes in orientation, angle did have a significant effect on reflectance values in TM3, TM4 and TM5. Specific differences were highly significant (P f or = 0.006) in all but one borderline (P F or = 0.0222) case for TM5. For spectral examination of excised leaves, the sampling arrangement of the leaves should as closely approximate in situ positioning as possible (with respect to remote sensing instrumentation). This dictates a random rather than aligned arrangement.

Yellow mealworm larvae (Tenebrio molitor) inclusion in diets for male broiler chickens: effects on growth performance, gut morphology, and histological findings.

PubMed

Biasato, I; Gasco, L; De Marco, M; Renna, M; Rotolo, L; Dabbou, S; Capucchio, M T; Biasibetti, E; Tarantola, M; Sterpone, L; Cavallarin, L; Gai, F; Pozzo, L; Bergagna, S; Dezzutto, D; Zoccarato, I; Schiavone, A

2018-02-01

This study evaluated the effects of Tenebrio molitor (TM) larvae meal inclusion in diets for broilers. A total of 160 male broiler chicks (Ross 708) at one-day of age were randomly allotted to four dietary treatments: a control (C) group and three TM groups, in which TM meal was included at 50 (TM5), 100 (TM10), and 150 (TM15) g/kg, respectively. The experimental diets were isonitrogenous and isoenergetic. Each group consisted of five pens as replicates (8 chicks/pen). After the evaluation of growth performance and haematochemical parameters, the animals were slaughtered at 53 days and carcass traits were recorded. Morphometric investigations were performed on duodenum, jejunum, and ileum and histopathological alterations were assessed for liver, spleen, thymus, bursa of Fabricius, kidney, and heart. The live weight (LW) showed a linear (12 and 25 days, P < 0.001 and P < 0.05, maximum with TM15 and TM10) and quadratic (53 days, P < 0.05, maximum with TM5) response to dietary TM meal inclusion. A linear (1 to 12 and 12 to 25 days, P < 0.001, maximum with TM15) and quadratic (12 to 25 days, P = 0.001, maximum with TM15) effect was also observed for the daily feed intake (DFI). The feed conversion ratio (FCR) showed a linear response (25 to 53 and 1 to 53 days, P = 0.001 and P < 0.05, maximum with TM15). Haematological and serum biochemical traits, carcass traits and histopathological findings were not affected by dietary TM meal inclusion (P > 0.05). TM15 birds showed lower villus height (P < 0.05), higher crypt depth (P < 0.05), and lower villus height to crypt depth ratio (P = 0.001) compared with C and TM5. In conclusion, increasing levels of dietary TM meal inclusion in male broiler chickens may improve body weight and feed intake, but negatively affect feed efficiency and intestinal morphology, thus suggesting that low levels may be more suitable. However, no effect on haematochemical parameters, carcass traits, and histological findings were observed in relation to TM meal utilization. © 2017 Poultry Science Association Inc.

Characterizing differences between MSCs and TM cells: Toward autologous stem cell therapies for the glaucomatous trabecular meshwork.

PubMed

Snider, Eric J; Vannatta, R Taylor; Schildmeyer, Lisa; Stamer, W Daniel; Ethier, C Ross

2018-03-01

Glaucoma, a leading cause of blindness, is characterized by an increase in intraocular pressure, which is largely determined by resistance to aqueous humour outflow through the trabecular meshwork (TM). In glaucoma, the cellularity of the TM is decreased, and, as a result, stem cell therapies for the TM represent a potential therapeutic option for restoring TM function and treating glaucoma patients. We here focus on adipose derived mesenchymal stem cells (MSCs) as a potential autologous cell source for TM regenerative medicine applications and describe characterization techniques at the messenger (reverse transcription-quantitative polymerase chain reaction), protein (western blotting, flow cytometry), and functional (contractility, phagocytosis) levels to distinguish MSCs from TM cells. We present a panel of 12 transcripts to allow: (a) suitable normalization of reverse transcription-quantitative polymerase chain reaction results across cell types and after exposure to potential differentiation stimuli; (b) distinguishing MSCs from TM cells; (c) distinguishing subtypes of TM cells; and (d) distinguishing TM cells from those in neighbouring tissue. At the protein level, dexamethasone induction of myocilin was a robust discriminating factor between MSCs and TM cells and was complemented by other protein markers. Finally, we show that contractility and phagocytosis differ between MSCs and TM cells. These methods are recommended for use in future differentiation studies to fully define if a functional TM-like phenotype is being achieved. Copyright © 2017 John Wiley & Sons, Ltd.

Computer code for scattering from impedance bodies of revolution. Part 3: Surface impedance with s and phi variation. Analytical and numerical results

NASA Technical Reports Server (NTRS)

Uslenghi, Piergiorgio L. E.; Laxpati, Sharad R.; Kawalko, Stephen F.

1993-01-01

The third phase of the development of the computer codes for scattering by coated bodies that has been part of an ongoing effort in the Electromagnetics Laboratory of the Electrical Engineering and Computer Science Department at the University of Illinois at Chicago is described. The work reported discusses the analytical and numerical results for the scattering of an obliquely incident plane wave by impedance bodies of revolution with phi variation of the surface impedance. Integral equation formulation of the problem is considered. All three types of integral equations, electric field, magnetic field, and combined field, are considered. These equations are solved numerically via the method of moments with parametric elements. Both TE and TM polarization of the incident plane wave are considered. The surface impedance is allowed to vary along both the profile of the scatterer and in the phi direction. Computer code developed for this purpose determines the electric surface current as well as the bistatic radar cross section. The results obtained with this code were validated by comparing the results with available results for specific scatterers such as the perfectly conducting sphere. Results for the cone-sphere and cone-cylinder-sphere for the case of an axially incident plane were validated by comparing the results with the results with those obtained in the first phase of this project. Results for body of revolution scatterers with an abrupt change in the surface impedance along both the profile of the scatterer and the phi direction are presented.

Trans-Laminar-Reinforced (TLR) Composites

NASA Technical Reports Server (NTRS)

Hinders, Mark; Dickinson, Larry

1997-01-01

A Trans-Laminar-Reinforced (TLR) composite is defined as composite laminate with up to five percent volume of fibrous reinforcement oriented in a 'trans-laminar' fashion in the through-thickness direction. The TLR can be continuous threads as in 'stitched laminates', or it can be discontinuous rods or pins as in 'Z-Fiber(TM) materials. It has been repeatedly documented in the literature that adding TLR to an otherwise two dimensional laminate results in the following advantages: substantially improved compression-after-impact response; considerably increased fracture toughness in mode 1 (double cantilever beam) and mode 2 (end notch flexure); and severely restricted size and growth of impact damage and edge delamination. TLR has also been used to eliminate catastrophic stiffener disbonding in stiffened structures. TLR directly supports the 'Achilles heel' of laminated composites, that is delamination. As little as one percent volume of TLR significantly alters the mechanical response of laminates. The objective of this work was to characterize the effects of TLR on the in-plane and inter-laminar mechanical response of undamaged composite laminates. Detailed finite element models of 'unit cells', or representative volumes, were used to study the effects of adding TLR on the elastic constants; the in-plane strength; and the initiation of delamination. Parameters investigated included TLR material, TLR volume fraction, TLR diameter, TLR through-thickness angle, ply stacking sequence, and the microstructural features of pure resin regions and curved in-plane fibers. The work was limited to the linear response of undamaged material with at least one ply interface. An inter-laminar dominated problem of practical interest, a flanged skin in bending, was also modeled.

The path of a click stimulus from ear canal to umbo.

PubMed

Milazzo, Mario; Fallah, Elika; Carapezza, Michael; Kumar, Nina S; Lei, Jason H; Olson, Elizabeth S

2017-03-01

The tympanic membrane (TM) has a key role in transmitting sounds to the inner ear, but a concise description of how the TM performs this function remains elusive. This paper probes TM operation by applying a free field click stimulus to the gerbil ear and exploring the consequent motions of the TM and umbo. Motions of the TM were measured both on radial tracks starting close to the umbo and on a grid distal and adjacent to the umbo. The experimental results confirmed the high fidelity of sound transmission from the ear canal to the umbo. A delay of 5-15 μs was seen in the onset of TM motion between points just adjacent to the umbo and mid-radial points. The TM responded with a ringing motion, with different locations possessing different primary ringing frequencies. A simple analytic model from the literature, treating the TM as a string, was used to explore the experimental results. The click-based experiments and analysis led to the following description of TM operation: A transient sound pressure on the TM causes a transient initial TM motion that is maximal ∼ at the TM's radial midpoints. Mechanical forces generated by this initial prominent TM distortion then pull the umbo inward, leading to a delayed umbo response. The initial TM deformation also gives rise to prolonged mechanical ringing on the TM that does not result in significant umbo motion, likely due to destructive interference from the range of ringing frequencies. Thus, the umbo's response is a high-fidelity representation of the transient stimulus. Because any sound can be considered as a consecutive series of clicks, this description is applicable to any sound stimulus. Copyright © 2017 Elsevier B.V. All rights reserved.

A Knowledge Navigation Method for the Domain of Customers' Services of Mobile Communication Corporations in China

NASA Astrophysics Data System (ADS)

Wu, Jiangning; Wang, Xiaohuan

Rapidly increasing amount of mobile phone users and types of services leads to a great accumulation of complaining information. How to use this information to enhance the quality of customers' services is a big issue at present. To handle this kind of problem, the paper presents an approach to construct a domain knowledge map for navigating the explicit and tacit knowledge in two ways: building the Topic Map-based explicit knowledge navigation model, which includes domain TM construction, a semantic topic expansion algorithm and VSM-based similarity calculation; building Social Network Analysis-based tacit knowledge navigation model, which includes a multi-relational expert navigation algorithm and the criterions to evaluate the performance of expert networks. In doing so, both the customer managers and operators in call centers can find the appropriate knowledge and experts quickly and exactly. The experimental results show that the above method is very powerful for knowledge navigation.

(Mechanisms of inhibition of viral replication in plants)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1991-01-01

During the last year we have made a number of important observations in the fields of virology and plant molecular biology. By directly sequencing Tomato Mosaic Virus (ToMV) movement genes, previously undetected sequence alterations common to specific viral strains were found. The difficulty in regenerating transgenic tomato plants containing the Tm-2 gene was overcome. Tobacco plants transformed with Cucumber Mosaic Virus (CMV) are being characterized. Analysis of transgenic tobacco plants expressing CMV coat protein have shown no correlation between coat protein expression and level of resistance. Specific amino acid changes have been found to correlate with CMV resistance breaking andmore » degree of pathogenicity. Satellite RNAs are shown to be too unstable for use as a biological control agent. The aphid transmission domain CMV has been localized to one (or more) of three amino acids; constructs have been made to determine the exact amino acids involved. 15 refs.« less

Evolution of Orbitrap Mass Spectrometry Instrumentation

NASA Astrophysics Data System (ADS)

Eliuk, Shannon; Makarov, Alexander

2015-07-01

We discuss the evolution of OrbitrapTM mass spectrometry (MS) from its birth in the late 1990s to its current role as one of the most prominent techniques for MS. The Orbitrap mass analyzer is the first high-performance mass analyzer that employs trapping of ions in electrostatic fields. Tight integration with the ion injection process enables the high-resolution, mass accuracy, and sensitivity that have become essential for addressing analytical needs in numerous areas of research, as well as in routine analysis. We examine three major families of instruments (related to the LTQ Orbitrap, Q Exactive, and Orbitrap Fusion mass spectrometers) in the context of their historical development over the past ten eventful years. We discuss as well future trends and perspectives of Orbitrap MS. We illustrate the compelling potential of Orbitrap-based mass spectrometers as (ultra) high-resolution platforms, not only for high-end proteomic applications, but also for routine targeted analysis.

MLP based LOGSIG transfer function for solar generation monitoring

NASA Astrophysics Data System (ADS)

Hashim, Fakroul Ridzuan; Din, Muhammad Faiz Md; Ahmad, Shahril; Arif, Farah Khairunnisa; Rizman, Zairi Ismael

2018-02-01

Solar panel is one of the renewable energy that can reduce the environmental pollution and have a wide potential of application. The exact solar prediction model will give a big impact on the management of solar power plants and the design of solar energy systems. This paper attempts to use Multilayer Perceptron (MLP) neural network based transfer function. The MLP network can be used to calculate the temperature module (TM) in Malaysia. This can be done by simulating the collected data of four weather variables which are the ambient temperature (TA), local wind speed (VW), solar radiation flux (GT) and the relative humidity (RH) as the input into the neural network. The transfer function will be applied to the 14 types of training. Finally, an equation from the best training algorithm will be deduced to calculate the temperature module based on the input of weather variables in Malaysia.

Biphasic rattlesnake venom-induced thrombocytopenia.

PubMed

Offerman, Steven R; Barry, J David; Schneir, Aaron; Clark, Richard F

2003-04-01

Thrombocytopenia is a common occurrence in moderate to severe crotaline envenomation. The exact mechanism by which rattlesnake venom leads to thrombocytopenia is unclear, but aggressive treatment with crotaline-specific antivenom often leads to resolution of this disorder. Crotalinae Polyvalent Immune Fab (CroFab(TM), Protherics Inc., Nashville, TN) (crotaline Fab) is now available for the treatment of symptomatic rattlesnake envenomation. Although recurrence of thrombocytopenia has been reported in patients after envenomation treated with crotaline Fab, cases refractory to this therapy have not been described. We report a case of severe crotaline envenomation that appears to have exhibited two separate episodes of thrombocytopenia, only one of which responded to antivenom. The second, later phase was refractory to both crotaline Fab as well as traditional Antivenin (Crotalinae) Polyvalent (Wyeth-Ayerst Pharmaceuticals, Philadelphia, PA) (ACP). By reviewing the literature regarding venom-induced thrombocytopenia, we attempt to explain this "biphasic" phenomenon and the inability of crotaline Fab to reverse this toxic effect.

A Mosaicking Approach for In Vivo Thickness Mapping of the Human Tympanic Membrane Using Low Coherence Interferometry.

PubMed

Pande, Paritosh; Shelton, Ryan L; Monroy, Guillermo L; Nolan, Ryan M; Boppart, Stephen A

2016-10-01

The thickness of the human tympanic membrane (TM) is known to vary considerably across different regions of the TM. Quantitative determination of the thickness distribution and mapping of the TM is of significant importance in hearing research, particularly in mathematical modeling of middle-ear dynamics. Change in TM thickness is also associated with several middle-ear pathologies. Determination of the TM thickness distribution could therefore also enable a more comprehensive diagnosis of various otologic diseases. Despite its importance, very limited data on human TM thickness distribution, obtained almost exclusively from ex vivo samples, are available in the literature. In this study, the thickness distribution for the in vivo human TM is reported for the first time. A hand-held imaging system, which combines a low coherence interferometry (LCI) technique for single-point thickness measurement, with video-otoscopy for recording the image of the TM, was used to collect the data used in this study. Data were acquired by pointing the imaging probe over different regions of the TM, while simultaneously recording the LCI and concomitant TM surface video image data from an average of 500 locations on the TM. TM thickness distribution maps were obtained by mapping the LCI imaging sites onto an anatomically accurate wide-field image of the TM, which was generated by mosaicking the sequence of multiple small field-of-view video-otoscopy images. Descriptive statistics of the thickness measurements obtained from the different regions of the TM are presented, and the general thickness distribution trends are discussed.

Temperature dependence of LRE-HRE-TM thin films

NASA Astrophysics Data System (ADS)

Li, Zuoyi; Cheng, Xiaomin; Lin, Gengqi; Li, Zhen; Huang, Zhixin; Jin, Fang; Wang, Xianran; Yang, Xiaofei

2003-04-01

Temperature dependence of the properties of RE-TM thin films is very important for MO recording. In this paper, we studied the temperature dependence of the magnetic and magneto-optical properties of the amorphous LRE-HRE-TM single layer thin films and LRE-HRE-TM/HRE-TM couple-bilayered thin films. For LRE-HRE-TM single layer thin films, the temperature dependence of the magnetization was investigated by using the mean field theory. The experimental and theoretical results matched very well. With the LRE substitution in HRE-TM thin film, the compensation temperature Tcomp decreased and the curie temperature Tc remained unchanged. Kerr rotation angle became larger and the saturation magnetization Ms at room temperature increased. For LRE-HRE-TM/HRE-TM couple-bilayered thin films, comparisons of the temperature dependences of the coercivities and Kerr rotation angles were made between isolated sublayers and couple-bilayered thin film.

Measurement of the 169Tm(n,3n) 167Tm cross section and the associated branching ratios in the decay of 167Tm [Measurement of the 169Tm(n,3n) 167Tm cross section and the branching ratios in the decay of 167Tm

DOE PAGES

Champine, B.; Gooden, M. E.; Krishichayan, .; ...

2016-01-14

The cross section for the 169Tm(n,3n) 167Tm reaction was measured from 17 to 22 MeV using quasimonoenergetic neutrons produced by the 2H(d,n) 3He reaction. This energy range was studied to resolve the discrepancy between previous (n,3n) cross-section measurements. In addition, the absolute γ-ray branching ratios following the electron-capture decay of 167Tm were measured. Furthermore, these results provide more reliable nuclear data for an important diagnostic that is used at the National Ignition Facility to estimate the yield of reaction-in-flight neutrons produced via the inertial-confinement-fusion plasma in deuterium-tritium capsules.

Human plasminogen kringle 1-5 inhibits angiogenesis and induces thrombomodulin degradation in a protein kinase A-dependent manner.

PubMed

Cho, Chia-Fong; Chen, Po-Ku; Chang, Po-Chiao; Wu, Hau-Lin; Shi, Guey-Yueh

2013-10-01

Kringle 1-5 (K1-5), an endogenous proteolytic fragment of human plasminogen (Plg), is an angiostatin-related protein that inhibits angiogenesis. Many angiostatin-related proteins have been identified, but the detailed molecular mechanisms underlying their antiangiogenic effects remain unclear. Thrombomodulin (TM) is a transmembrane glycoprotein that plays a major role in the anticoagulation process in endothelial cells. Previously, we demonstrated that recombinant TM could interact with Plg to enhance Plg activation. In the present study, we investigated the interaction between TM and K1-5, and their functions in endothelial cells. We found that K1-5 colocalized with TM and directly interacted with TM through the TM lectin-like domain. After K1-5 interacted with TM, it induced TM internalization and degradation. In addition, the K1-5-induced TM internalization and degradation in proteasomes after ubiquitin modification were dependent on protein kinase A (PKA). Moreover, a PKA-specific inhibitor reversed the effects of K1-5 on cell migration and tube formation. Consistent with these findings, TM overexpression resulted in increased cell migration; moreover, K1-5 inhibited the increase of TM-mediated cell migration in a PKA-dependent manner. We determined that TM acts as a K1-5 receptor and that K1-5 induces TM internalization, ubiquitination, and degradation through the PKA pathway, by which K1-5 may inhibit endothelial cell migration and tube formation. © 2013. Published by Elsevier Ltd. All rights reserved.

Ligand-induced conformational changes in the Bacillus subtilis chemoreceptor McpB determined by disulfide crosslinking in vivo.

PubMed

Szurmant, Hendrik; Bunn, Michael W; Cho, Stephen H; Ordal, George W

2004-12-03

Previously, we characterized the organization of the transmembrane (TM) domain of the Bacillus subtilis chemoreceptor McpB using disulfide crosslinking. Cysteine residues were engineered into serial positions along the two helices through the membrane, TM1 and TM2, as well as double mutants in TM1 and TM2, and the extent of crosslinking determined to characterize the organization of the TM domain. In this study, the organization of the TM domain was studied in the presence and absence of ligand to address what ligand-induced structural changes occur. We found that asparagine caused changes in crosslinking rate on all residues along the TM1-TM1' helical interface, whereas the crosslinking rate for almost all residues along the TM2-TM2' interface did not change. These results indicated that helix TM1 rotated counterclockwise and that TM2 did not move in respect to TM2' in the dimer on binding asparagine. Interestingly, intramolecular crosslinking of paired substitutions in 34/280 and 38/273 were unaffected by asparagine, demonstrating that attractant binding to McpB did not induce a "piston-like" vertical displacement of TM2 as seen for Trg and Tar in Escherichia coli. However, these paired substitutions produced oligomeric forms of receptor in response to ligand. This must be due to a shift of the interface between different receptor dimers, within previously suggested trimers of dimers, or even higher order complexes. Furthermore, the extent of disulfide bond formation in the presence of asparagine was unaffected by the presence of the methyl-modification enzymes, CheB and CheR, or the coupling proteins, CheW and CheV, demonstrating that these proteins must have local structural effects on the cytoplasmic domain that is not translated to the entire receptor. Finally, disulfide bond formation was also unaffected by binding proline to McpC. We conclude that ligand-binding induced a conformational change in the TM domain of McpB dimers as an excitation signal that is likely propagated within the cytoplasmic region of receptors and that subsequent adaptational events do not affect this new TM domain conformation.

Cysteine Substitution of Transmembrane Domain Amino Acids Alters the Ethanol Inhibition of GluN1/GluN2A N-Methyl-d-Aspartate Receptors

PubMed Central

Xu, Minfu; Smothers, C. Thetford

2015-01-01

N-Methyl-d-aspartate receptors (NMDARs) are inhibited by behaviorally relevant concentrations of ethanol, and residues within transmembrane (TM) domains of NMDARs, including TM3 GluN1 phenylalanine 639 (F639), regulate this sensitivity. In the present study, we used cysteine (C) mutagenesis to determine whether there are additional residues within nearby TM domains that regulate ethanol inhibition on NMDARs. GluN1(F639C)/GluN2A receptors were less inhibited by ethanol than wild-type receptors, and inhibition was restored to wild-type levels following treatment with ethanol-like methanethiosulfonate reagents. Molecular modeling identified six residues in the GluN1 TM1 domain (valine V566; serine S569) and the GluN2A TM4 domain (methionine, M817; V820, F821, and leucine, L824) that were in close vicinity to the TM3 F639 residue, and these were individually mutated to cysteine and tested for ethanol inhibition and receptor function. The F639C-induced decrease in ethanol inhibition was blunted by coexpression of GluN1 TM1 mutants V566C and S569C, and statistically significant interactions were observed for ethanol inhibition among V566C, F639C, and GluN2A TM4 mutants V820C and F821C and S569C, F639C, and GluN2A TM4 mutants F821C and L824C. Ethanol inhibition was also reduced when either GluN1 TM1 mutant V566C or S569C was combined with GluN2A V820C, suggesting a novel TM1:TM4 intrasubunit site of action for ethanol. Cysteines substituted at TM3 and TM4 sites previously suggested to interact with ethanol had less dramatic effects on ethanol inhibition. Overall, the results from these studies suggest that interactions among TM1, TM3, and TM4 amino acids in NMDARs are important determinants of ethanol action at these receptors. PMID:25635140

Exact Solution of the Two-Dimensional Problem on an Impact Ideal-Liquid Jet

NASA Astrophysics Data System (ADS)

Belik, V. D.

2018-05-01

The two-dimensional problem on the collision of a potential ideal-liquid jet, outflowing from a reservoir through a nozzle, with an infinite plane obstacle was considered for the case where the distance between the nozzle exit section and the obstacle is finite. An exact solution of this problem has been found using methods of the complex-variable function theory. Simple analytical expressions for the complex velocity of the liquid, its flow rate, and the force of action of the jet on the obstacle have been obtained. The velocity distributions of the liquid at the nozzle exit section, in the region of spreading of the jet, and at the obstacle have been constructed for different distances between the nozzle exit section and the obstacle. Analytical expressions for the thickness of the boundary layer and the Nusselt number at the point of stagnation of the jet have been obtained. A number of distributions of the local friction coefficient and the Nusselt number of the indicated jet are presented.

Brownian motion in non-equilibrium systems and the Ornstein-Uhlenbeck stochastic process.

PubMed

Donado, F; Moctezuma, R E; López-Flores, L; Medina-Noyola, M; Arauz-Lara, J L

2017-10-03

The Ornstein-Uhlenbeck stochastic process is an exact mathematical model providing accurate representations of many real dynamic processes in systems in a stationary state. When applied to the description of random motion of particles such as that of Brownian particles, it provides exact predictions coinciding with those of the Langevin equation but not restricted to systems in thermal equilibrium but only conditioned to be stationary. Here, we investigate experimentally single particle motion in a two-dimensional granular system in a stationary state, consisting of 1 mm stainless balls on a plane circular surface. The motion of the particles is produced by an alternating magnetic field applied perpendicular to the surface of the container. The mean square displacement of the particles is measured for a range of low concentrations and it is found that following an appropriate scaling of length and time, the short-time experimental curves conform a master curve covering the range of particle motion from ballistic to diffusive in accordance with the description of the Ornstein-Uhlenbeck model.

Ising antiferromagnet on a finite triangular lattice with free boundary conditions

NASA Astrophysics Data System (ADS)

Kim, Seung-Yeon

2015-11-01

The exact integer values for the density of states of the Ising model on an equilateral triangular lattice with free boundary conditions are evaluated up to L = 24 spins on a side for the first time by using the microcanonical transfer matrix. The total number of states is 2 N s = 2300 ≈ 2.037 × 1090 for L = 24, where N s = L( L+1)/2 is the number of spins. Classifying all 2300 spin states according to their energy values is an enormous work. From the density of states, the exact partition function zeros in the complex temperature plane of the triangular-lattice Ising model are evaluated. Using the density of states and the partition function zeros, we investigate the properties of the triangularlattice Ising antiferromagnet. The scaling behavior of the ground-state entropy and the form of the correlation length at T = 0 are studied for the triangular-lattice Ising antiferromagnet with free boundary conditions. Also, the scaling behavior of the Fisher edge singularity is investigated.

Anisotropic reflectance from turbid media. I. Theory.

PubMed

Neuman, Magnus; Edström, Per

2010-05-01

It is shown that the intensity of light reflected from plane-parallel turbid media is anisotropic in all situations encountered in practice. The anisotropy, in the form of higher intensity at large polar angles, increases when the amount of near-surface bulk scattering is increased, which dominates in optically thin and highly absorbing media. The only situation with isotropic intensity is when a non-absorbing infinitely thick medium is illuminated diffusely. This is the only case where the Kubelka-Munk model gives exact results and there exists an exact translation between Kubelka-Munk and general radiative transfer. This also means that a bulk scattering perfect diffusor does not exist. Angle-resolved models are thus crucial for a correct understanding of light scattering in turbid media. The results are derived using simulations and analytical calculations. It is also shown that there exists an optimal angle for directional detection that minimizes the error introduced when using the Kubelka-Munk model to interpret reflectance measurements with diffuse illumination.

An exact solution for a rotating black hole in modified gravity

NASA Astrophysics Data System (ADS)

Filippini, Francesco; Tasinato, Gianmassimo

2018-01-01

Exact solutions describing rotating black holes can offer important tests for alternative theories of gravity, motivated by the dark energy and dark matter problems. We present an analytic rotating black hole solution for a class of vector-tensor theories of modified gravity, valid for arbitrary values of the rotation parameter. The new configuration is characterised by parametrically large deviations from the Kerr-Newman geometry, controlled by non-minimal couplings between vectors and gravity. It has an oblate horizon in Boyer-Lindquist coordinates, and it can rotate more rapidly and have a larger ergosphere than black holes in General Relativity (GR) with the same asymptotic properties. We analytically investigate the features of the innermost stable circular orbits for massive objects on the equatorial plane, and show that stable orbits lie further away from the black hole horizon with respect to rotating black holes in GR. We also comment on possible applications of our findings for the extraction of rotational energy from the black hole.

Corrective Osteotomy for Symptomatic Clavicle Malunion Using Patient-specific Osteotomy and Reduction Guides.

PubMed

Haefeli, Mathias; Schenkel, Matthias; Schumacher, Ralf; Eid, Karim

2017-09-01

Midshaft clavicular fractures are often treated nonoperatively with good reported clinical outcome in a majority of patients. However, malunion with shortening of the affected clavicle is not uncommon. Shortening of the clavicle has been shown to affect shoulder strength and kinematics with alteration of scapular position. Whereas the exact clinical impact of these factors is unknown, the deformity may lead to cosmetic and functional impairment as for example pain with weight-bearing on the shoulder girdle. Other reported complications of clavicular malunion include thoracic outlet syndrome, subclavicular vein thrombosis, and axillary plexus compression. Corrective osteotomy has therefore been recommended for symptomatic clavicular malunions, generally using plain x-rays for planning the necessary elongation. Particularly in malunited multifragmentary fractures it may be difficult to exactly determine the plane of osteotomy intraoperatively to restore the precise anatomic shape of the clavicle. We present a technique for corrective osteotomy using preoperative computer planning and 3-dimensional printed patient-specific intraoperative osteotomy and reduction guides based on the healthy contralateral clavicle.

Holographic otoscope for nano-displacement measurements of surfaces under dynamic excitation

PubMed Central

Flores-Moreno, J. M.; Furlong, Cosme; Rosowski, John J.; Harrington, Ellery; Cheng, Jeffrey T.; Scarpino, C.; Santoyo, F. Mendoza

2011-01-01

Summary We describe a novel holographic otoscope system for measuring nano-displacements of objects subjected to dynamic excitation. Such measurements are necessary to quantify the mechanical deformation of surfaces in mechanics, acoustics, electronics, biology and many other fields. In particular, we are interested in measuring the sound-induced motion of biological samples, such as an eardrum. Our holographic otoscope system consists of laser illumination delivery (IS), optical head (OH), and image processing computer (IP) systems. The IS delivers the object beam (OB) and the reference beam (RB) to the OH. The backscattered light coming from the object illuminated by the OB interferes with the RB at the camera sensor plane to be digitally recorded as a hologram. The hologram is processed by the IP using Fresnel numerical reconstruction algorithm, where the focal plane can be selected freely. Our holographic otoscope system is currently deployed in a clinic, and is packaged in a custom design. It is mounted in a mechatronic positioning system to increase its maneuverability degrees to be conveniently positioned in front of the object to be measured. We present representative results highlighting the versatility of our system to measure deformations of complex elastic surfaces in the wavelength scale including a copper foil membrane and postmortem tympanic membrane (TM). PMID:21898459

REVISITING THE ISN FLOW PARAMETERS, USING A VARIABLE IBEX POINTING STRATEGY

DOE Office of Scientific and Technical Information (OSTI.GOV)

Leonard, T. W.; Möbius, E.; Heirtzler, D.

2015-05-01

The Interstellar Boundary Explorer (IBEX) has observed the interstellar neutral (ISN) gas flow over the past 6 yr during winter/spring when the Earth’s motion opposes the ISN flow. Since IBEX observes the interstellar atom trajectories near their perihelion, we can use an analytical model based upon orbital mechanics to determine the interstellar parameters. Interstellar flow latitude, velocity, and temperature are coupled to the flow longitude and are restricted by the IBEX observations to a narrow tube in this parameter space. In our original analysis we found that pointing the spacecraft spin axis slightly out of the ecliptic plane significantly influencesmore » the ISN flow vector determination. Introducing the spacecraft spin axis tilt into the analytical model has shown that IBEX observations with various spin axis tilt orientations can substantially reduce the range of acceptable solutions to the ISN flow parameters as a function of flow longitude. The IBEX operations team pointed the IBEX spin axis almost exactly within the ecliptic plane during the 2012–2014 seasons, and about 5° below the ecliptic for half of the 2014 season. In its current implementation the analytical model describes the ISN flow most precisely for the spin axis orientation exactly in the ecliptic. This analysis refines the derived ISN flow parameters with a possible reconciliation between velocity vectors found with IBEX and Ulysses, resulting in a flow longitude λ{sub ∞} = 74.°5 ± 1.°7 and latitude β{sub ∞} = −5.°2 ± 0.°3, but at a substantially higher ISN temperature than previously reported.« less

Direct-Acting Antiviral Therapy Outcomes in Canadian Chronic Hepatitis C Telemedicine Patients.

PubMed

Cooper, Curtis L; Hatashita, Holly; Corsi, Daniel J; Parmar, Parmvir; Corrin, Raymond; Garber, Gary

Many of the 300,000 HCV-infected Canadians live in under-served and remote areas without access to HCV healthcare specialists. Telemedicine (TM) and advances in HCV management can facilitate linkage of these marginalized patients to healthcare. A cohort database analysis was performed on patients followed at The Ottawa Hospital and Regional Viral Hepatitis Program between January 2012 and August 2016. We compared patient characteristics, fibrosis work-up and antiviral treatment outcomes in TM (n = 157) and non-TM (n = 1,130) patients (The Ottawa Hospital Viral Hepatitis Outpatient Clinic) residing in Eastern Ontario. TM patients were more often infected with genotype 3 (25.9% vs. 16.4%), were more commonly Indigenous (7.0% vs. 2.2%) had a history of injection drug use (70.1% vs. 54.9%) and incarceration (46.5% vs 35.5%). Groups were comparable in age (48.9 years), gender (63.7% male) and cirrhotic stage (24.0%). 59.2% of TM patients underwent transient elastography during regional outreach blitzes compared to 61.8% of non-TM patients (p = 0.54). Overall, half as many TM patients initiated antiviral therapy as non-TM patients (27.4% vs. 53.8%, p < 0.001). The introduction of DAA regimens is bridging this gap (22.2% of TM patients vs. 34.3% of non-TM patients). SVR rates with interferon-free, DAA regimens were 94.7% and 94.8% in TM and non-TM groups (p = 0.99). Our TM program engages and retains a population that faces many barriers to effective HCV treatment. TM patients initiated HCV therapy and achieved High SVR rates comparable to those obtained using traditional models of care.

Effect of silica surface coating on the luminescence lifetime and upconversion temperature sensing properties of semiconductor zinc oxide doped with gallium(III) and sensitized with rare earth ions Yb(III) and Tm(III).

PubMed

Li, Yuemei; Li, Yongmei; Wang, Rui; Zheng, Wei

2018-02-26

Optical sensing of temperature by measurement of the ratio of the intensities of the 700 nm emission and the 800 nm emission of Ga(III)-doped ZnO (GZO) nanoparticles (NPs) and of GZO NPs coated with a silica shell are demonstrated at 980 nm excitation. It is found that the relative sensitivity of SiO 2 @Yb/Tm/GZO is 6.2% K -1 at a temperature of 693 K. This is ~3.4 times higher than that of Yb/Tm/GZO NPs. Obviously, the SiO 2 shell structure decreases the rate of the nonradiative decay. The decay time of the 800 nm emission of the Yb/Tm/GZO NPs (15 mol% Ga; 7 mol% Yb; 0.5 mol% Tm) displays a biexponential decay with a dominant decay time of 148 μs and a second decay time of ~412 μs. The lifetime of the Yb/Tm/GZO NPs at 293 K, and of the SiO 2 @Yb/Tm/GZO NPs are ~412 μs. Both the Yb/Tm/GZO and SiO 2 @Yb/Tm/GZO can be used up to 693 K. These results indicate that the SiO 2 shell on the Yb/Tm/GZO is beneficial in terms of sensitivity and resolution. Graphical abstract The enhancement the decay time and thermal sensitivity in the SiO 2 @Yb/Tm/GZO shell@core structure have been studied compared to the Ga(III)-doped Yb/Tm-doped ZnO (Yb/Tm/GZO). The SiO 2 @Yb/Tm/GZO have good thermal accuracy up to 693 °C.

The path of a click stimulus from earcanal to umbo

PubMed Central

Milazzo, Mario; Fallah, Elika; Carapezza, Michael; Kumar, Nina S.; Lei, Jason H.; Olson, Elizabeth S.

2017-01-01

The tympanic membrane (TM) has a key role in transmitting sounds to the inner ear, but a concise description of how the TM performs this function remains elusive. This paper probes TM operation by applying a free field click stimulus to the gerbil ear and exploring the consequent motions of the TM and umbo. Motions of the TM were measured both on radial tracks starting close to the umbo and on a grid distal and adjacent to the umbo. The experimental results confirmed the high fidelity of sound transmission from the ear canal to the umbo. A delay of 5 – 15 μs was seen in the onset of TM motion between points just adjacent to the umbo and mid-radial points. The TM responded with a ringing motion, with different locations possessing different primary ringing frequencies. A simple analytic model from the literature, treating the TM as a string, was used to explore the experimental results. The click-based experiments and analysis led to the following description of TM operation: A transient sound pressure on the TM causes a transient initial TM motion that is maximal ~ at the TM’s radial midpoints. Mechanical forces generated by this initial prominent TM distortion then pull the umbo inward, leading to a delayed umbo response. The initial TM deformation also gives rise to prolonged mechanical ringing on the TM that does not result in significant umbo motion, likely due to destructive interference from the range of ringing frequencies. Thus, the umbo’s response is a high-fidelity representation of the transient stimulus. Because any sound can be considered as a consecutive series of clicks, this description is applicable to any sound stimulus. PMID:28087416

Wafer plane inspection with soft resist thresholding

NASA Astrophysics Data System (ADS)

Hess, Carl; Shi, Rui-fang; Wihl, Mark; Xiong, Yalin; Pang, Song

2008-10-01

Wafer Plane Inspection (WPI) is an inspection mode on the KLA-Tencor TeraScaTM platform that uses the high signalto- noise ratio images from the high numerical aperture microscope, and then models the entire lithographic process to enable defect detection on the wafer plane[1]. This technology meets the needs of some advanced mask manufacturers to identify the lithographically-significant defects while ignoring the other non-lithographically-significant defects. WPI accomplishes this goal by performing defect detection based on a modeled image of how the mask features would actually print in the photoresist. There are several advantages to this approach: (1) the high fidelity of the images provide a sensitivity advantage over competing approaches; (2) the ability to perform defect detection on the wafer plane allows one to only see those defects that have a printing impact on the wafer; (3) the use of modeling on the lithographic portion of the flow enables unprecedented flexibility to support arbitrary illumination profiles, process-window inspection in unit time, and combination modes to find both printing and non-printing defects. WPI is proving to be a valuable addition to the KLA-Tencor detection algorithm suite. The modeling portion of WPI uses a single resist threshold as the final step in the processing. This has been shown to be adequate on several advanced customer layers, but is not ideal for all layers. Actual resist chemistry has complicated processes including acid and base-diffusion and quench that are not consistently well-modeled with a single resist threshold. We have considered the use of an advanced resist model for WPI, but rejected it because the burdensome requirements for the calibration of the model were not practical for reticle inspection. This paper describes an alternative approach that allows for a "soft" resist threshold to be applied that provides a more robust solution for the most challenging processes. This approach is just finishing beta testing with a customer developing advanced node designs.

Intersubband spectroscopy of ZnO/ZnMgO quantum wells grown on m-plane ZnO substrates for quantum cascade device applications (Conference Presentation)

NASA Astrophysics Data System (ADS)

Quach, Patrick; Jollivet, Arnaud; Isac, Nathalie; Bousseksou, Adel; Ariel, Frédéric; Tchernycheva, Maria; Julien, François H.; Montes Bajo, Miguel; Tamayo-Arriola, Julen; Hierro, Adrián.; Le Biavan, Nolwenn; Hugues, Maxime; Chauveau, Jean-Michel

2017-03-01

Quantum cascade (QC) lasers opens new prospects for powerful sources operating at THz frequencies. Up to now the best THz QC lasers are based on intersubband emission in GaAs/AlGaAs quantum well (QW) heterostructures. The maximum operating temperature is 200 K, which is too low for wide-spread applications. This is due to the rather low LO-phonon energy (36 meV) of GaAs-based materials. Indeed, thermal activation allows non-radiative path through electron-phonon interaction which destroys the population inversion. Wide band gap materials such as ZnO have been predicted to provide much higher operating temperatures because of the high value of their LO-phonon energy. However, despite some observations of intersubband absorption in c-plane ZnO/ZnMgO quantum wells, little is known on the fundamental parameters such as the conduction band offset in such heterostructures. In addition the internal field inherent to c-plane grown heterostuctures is an handicap for the design of QC lasers and detectors. In this talk, we will review a systematic investigation of ZnO/ZnMgO QW heterostructures with various Mg content and QW thicknesses grown by plasma molecular beam epitaxy on low-defect m-plane ZnO substrates. We will show that most samples exhibit TM-polarized intersubband absorption at room temperature linked either to bound-to-quasi bound inter-miniband absorption or to bound-to bound intersubband absorption depending on the Mg content of the barrier material. This systematic study allows for the first time to estimate the conduction band offset of ZnO/ZnMgO heterostructures, opening prospects for the design of QC devices operating at THz frequencies. This was supported by the European Union's Horizon 2020 research and innovation programme under grant agreement #665107.

Inhibition of allergic bronchial asthma by thrombomodulin is mediated by dendritic cells.

PubMed

Takagi, Takehiro; Taguchi, Osamu; Toda, Masaaki; Ruiz, Daniel Boveda; Bernabe, Paloma Gil; D'Alessandro-Gabazza, Corina N; Miyake, Yasushi; Kobayashi, Tetsu; Aoki, Shinya; Chiba, Fumiko; Yano, Yutaka; Conway, Edward M; Munesue, Seiichi; Yamamoto, Yasuhiko; Yamamoto, Hiroshi; Suzuki, Koji; Takei, Yoshiyuki; Morser, John; Gabazza, Esteban C

2011-01-01

bronchial asthma is caused by inappropriate acquired immune responses to environmental allergens. It is a major health problem, with a prevalence that is rapidly increasing. Curative therapy is not currently available. to test the hypothesis that thrombomodulin (TM) inhibits allergic bronchial asthma by inducing tolerogenic dendritic cells (DCs). the protective effect of TM was evaluated using a murine asthma model. Asthma was induced in mice by exposure to chicken egg ovalbumin, and the effects of inhaled TM or TM-treated DCs were assessed by administering before ovalbumin exposure. treatment with TM protects against bronchial asthma measured as improved lung function and reduced IgE and cells in alveolar lavage fluid by inducing tolerogenic dendritic dells. These are characterized by high expression of surface TM (CD141/TM(+)) and low expression of maturation markers and possess reduced T-cell costimulatory activity. The CD141/TM(+) DCs migrate less toward chemokines, and after TM treatment there are fewer DCs in the draining lymph node and more in the lungs. The TM effect is independent of its role in coagulation. Rather, it is mediated via the TM lectin domain directly interacting with the DCs. the results of this study show that TM is a modulator of DC immunostimulatory properties and a novel candidate drug for the prevention of bronchial asthma in atopic patients.

Thrombomodulin-mediated cell adhesion: involvement of its lectin-like domain.

PubMed

Huang, Huey-Chun; Shi, Guey-Yueh; Jiang, Shinn-Jong; Shi, Chung-Sheng; Wu, Chun-Mei; Yang, Hsi-Yuan; Wu, Hua-Lin

2003-11-21

Thrombomodulin (TM) is an integral membrane glycoprotein that is a potent anticoagulant factor. TM may also possess functions distinct from its anticoagulant activity. Here the influence of TM on cell adhesion was studied in TM-negative melanoma A2058 cells transfected with green fluorescent protein-tagged TM (TMG) or lectin domain-deleted TM (TMG(DeltaL)). Confocal microscopy demonstrated that both TMG and TMG(DeltaL) were distributed in the plasma membrane. TMG-expressed cells grew as closely clustered colonies, with TM localized prominently in the intercellular boundaries. TMG(DeltaL)-expressed cells grew singly. Overexpression of TMG, but not TMG(DeltaL), decreased monolayer permeability in vitro and tumor growth in vivo. The cell-to-cell adhesion in TMG-expressed cells was Ca2+-dependent and was inhibited by monoclonal antibody against the lectin-like domain of TM. The effects of TM-mediated cell adhesion were abolished by the addition of mannose, chondroitin sulfate A, or chondroitin sulfate C. In addition, anti-lectin-like domain antibody disrupted the close clustering of the endogenous TM-expressed keratinocyte HaCaT cell line derived from normal human epidermis. Double-labeling immunofluorescence staining revealed similar distributions of TM and actin filament in the cortex region of the TMG-expressed cells. Thus, TM can function as a Ca2+-dependent cell-to-cell adhesion molecule. Binding of specific carbohydrates to the lectin-like domain is essential for this specific function.

ANTHROPOMORPHIC PHANTOMS FOR ASSESSMENT OF STRAIN IMAGING METHODS INVOLVING SALINE-INFUSED SONOHYSTEROGRAPHY

PubMed Central

Hobson, Maritza A.; Madsen, Ernest L.; Frank, Gary R.; Jiang, Jingfeng; Shi, Hairong; Hall, Timothy J.; Varghese, Tomy

2008-01-01

Two anthropomorphic uterine phantoms were developed which allow assessment and comparison of strain imaging systems adapted for use with saline-infused sonohysterography (SIS). Tissue-mimicking (TM) materials consist of dispersions of safflower oil in gelatin. TM fibroids are stiffer than the TM myometrium/cervix and TM polyps are softer. The first uterine phantom has 3-mm diameter TM fibroids randomly distributed in TM myometrium. The second uterine phantom has a 5-mm and an 8-mm spherical TM fibroid in addition to a 5-mm spherical and a 12.5-mm long (medicine-capsule-shaped) TM endometrial polyp protruding into the endometrial cavity; also, a 10-mm spherical TM fibroid projects from the serosal surface. Strain images using the first phantom show the stiffer 3-mm TM fibroids in the myometrium. Results from the second uterine phantom show that, as expected, parts of inclusions projecting into the uterine cavity will appear very stiff, whether they are stiff or soft. Results from both phantoms show that even though there is a five-fold difference in the Young’s moduli values, there is not a significant difference in the strain in the transition from the TM myometrium to the TM fat. These phantoms allow for realistic comparison and evolution of SIS strain imaging techniques and can aid clinical personnel to develop skills for SIS strain imaging. PMID:18514999

Self-renewal and circulating capacities of metastatic hepatocarcinoma cells required for collaboration between TM4SF5 and CD44

PubMed Central

Lee, Doohyung; Lee, Jung Weon

2015-01-01

Tumor metastasis involves circulating and tumor-initiating capacities of metastatic cancer cells. Hepatic TM4SF5 promotes EMT for malignant growth and migration. Hepatocellular carcinoma (HCC) biomarkers remain unexplored for metastatic potential throughout metastasis. Here, novel TM4SF5/CD44 interaction-mediated self-renewal and circulating tumor cell (CTC) capacities were mechanistically explored. TM4SF5-dependent sphere growth was correlated with CD133+, CD24-, ALDH activity, and a physical association between CD44 and TM4SF5. The TM4SF5/CD44 interaction activated c-Src/STAT3/ Twist1/ B mi1 signaling for spheroid formation, while disturbing the interaction, expression, or activity of any component in this signaling pathway inhibited spheroid formation. In serial xenografts of less than 5,000 cells/injection, TM4SF5-positive tumors exhibited locally-increased CD44 expression, suggesting tumor cell differentiation. TM4SF5-positive cells were identified circulating in blood 4 to 6 weeks after orthotopic liver-injection. Anti-TM4SF reagents blocked their metastasis to distal intestinal organs. Altogether, our results provide evidence that TM4SF5 promotes self-renewal and CTC properties supported by CD133+/TM4SF5+/CD44+(TM4SF5-bound)/ALDH+/ CD24- markers during HCC metastasis. [BMB Reports 2015; 48(3): 127-128] PMID:25772760

Fully "Eqwipped" to See the Heat

NASA Technical Reports Server (NTRS)

2002-01-01

Developed by NASA's Jet Propulsion Laboratory over the past decade with an excess of $15 million of government research and development investment, quantum well infrared photodetectors (QWIPs) are infrared imaging sensors that can operate in the long wavelength portion of the electromagnetic spectrum, where objects at an ambient temperature emit the most energy. QWIPTECH was formed in July 1998 to offer JPL's QWIPs in a commercial format. The company currently holds an exclusive worldwide license to manufacture and sell the infrared photodetector sensors as part of a focal plane array called a QWIP Chip(TM). The QWIP Chip provides high thermal sensitivity (0.001 C) and possesses a broad dynamic range, permitting precise observations over a wide range of temperatures. Since the technology uses heat rather than light, it can "see" in complete darkness and through conditions such as dust, smoke, and light fog.

Point interactions, metamaterials, and PT-symmetry

NASA Astrophysics Data System (ADS)

Mostafazadeh, Ali

2016-05-01

We express the boundary conditions for TE and TM waves at the interfaces of an infinite planar slab of homogeneous metamaterial as certain point interactions and use them to compute the transfer matrix of the system. This allows us to demonstrate the omnidirectional reflectionlessness of Veselago's slab for waves of arbitrary wavelength, reveal the translational and reflection symmetry of this slab, explore the laser threshold condition and coherent perfect absorption for active negative-index metamaterials, introduce a point interaction modeling phase-conjugation, determine the corresponding antilinear transfer matrix, and offer a simple proof of the equivalence of Veselago's slab with a pair of parallel phase-conjugating plates. We also study the connection between certain optical setups involving metamaterials and a class of PT-symmetric quantum systems defined on wedge-shape contours in the complex plane. This provides a physical interpretation for the latter.

An ultrasound needle insertion guide in a porcine phantom model.

PubMed

Whittaker, S; Lethbridge, G; Kim, C; Keon Cohen, Z; Ng, I

2013-08-01

We compared nerve blockade with and without the Infiniti(TM) needle guide in an ultrasound in-plane porcine simulation. We recruited 30 anaesthetists with varying blockade experience. Using the guide, the needle tip was more visible (for a median (IQR [range]) of 67 (56-100]) % of the time; and invisible for 2 (1-4 [0-19]) s) than when the guide was not used (respectively 23 (13-43 [0-80]) % and 25 (9-52 [1-198]) s; both p < 0.001). The corresponding block times were 8 (6-10 [3-28]) s and 32 (15-67 [5-225]) s, respectively; p < 0.001. The needle guide reduced the block time and the time that the needle was invisible, irrespective of anaesthetist experience. Anaesthesia © 2013 The Association of Anaesthetists of Great Britain and Ireland.

Unique Reactivity of Transition Metal Atoms Embedded in Graphene to CO, NO, O₂ and O Adsorption: A First-Principles Investigation.

PubMed

Chu, Minmin; Liu, Xin; Sui, Yanhui; Luo, Jie; Meng, Changgong

2015-10-27

Taking the adsorption of CO, NO, O₂ and O as probes, we investigated the electronic structure of transition metal atoms (TM, TM = Fe, Co, Ni, Cu and Zn) embedded in graphene by first-principles-based calculations. We showed that these TM atoms can be effectively stabilized on monovacancy defects on graphene by forming plausible interactions with the C atoms associated with dangling bonds. These interactions not only give rise to high energy barriers for the diffusion and aggregation of the embedded TM atoms to withstand the interference of reaction environments, but also shift the energy levels of TM-d states and regulate the reactivity of the embedded TM atoms. The adsorption of CO, NO, O₂ and O correlates well with the weight averaged energy level of TM-d states, showing the crucial role of interfacial TM-C interactions on manipulating the reactivity of embedded TM atoms. These findings pave the way for the developments of effective monodispersed atomic TM composites with high stability and desired performance for gas sensing and catalytic applications.

Performance evaluation and geologic utility of LANDSAT 4 TM and MSS scanners

NASA Technical Reports Server (NTRS)

Paley, H. N.

1983-01-01

Experiments using artificial targets (polyethylene sheets) to help calibrate and evaluate atmospheric effects as well as the radiometric precision and spatial characteristics of the NS-001 and TM sensor systems were attempted and show the technical feasibility of using plastic targets for such studies, although weather precluded successful TM data acquisition. Tapes for six LANDSAT 4 TM scenes were acquired and data processing began. Computer enhanced TM simulator and LANDSAT 4 TM data were compared for a porphyry copper deposit in Southern Arizona. Preliminary analyses performed on two TM scenes acquired in the CCT-PT format, show the TM data appear to contain a marked increase in geologically useful information; however, a number of instrumental processing artifacts may well limit the ability of the geologist to fully extract this information.

Nurse perspectives on the implementation of routine telemonitoring for high-risk diabetes patients in a primary care setting.

PubMed

Vest, Bonnie M; Hall, Victoria M; Kahn, Linda S; Heider, Arvela R; Maloney, Nancy; Singh, Ranjit

2017-01-01

Aims The purpose of this qualitative evaluation was to explore the experience of implementing routine telemonitoring (TM) in real-world primary care settings from the perspective of those delivering the intervention; namely the TM staff, and report on lessons learned that could inform future projects of this type. Routine TM for high-risk patients within primary care practices may help improve chronic disease control and reduce complications, including unnecessary hospital admissions. However, little is known about how to integrate routine TM in busy primary care practices. A TM pilot for diabetic patients was attempted in six primary care practices as part of the Beacon Community in Western New York. Semi-structured interviews were conducted with representatives of three TM agencies (n=8) participating in the pilot. Interviews were conducted over the phone or in person and lasted ~30 min. Interviews were audio-taped and transcribed. Analysis was conducted using immersion-crystallization to identify themes. Findings TM staff revealed several themes related to the experience of delivering TM in real-world primary care: (1) the nurse-patient relationship is central to a successful TM experience, (2) TM is a useful tool for understanding socio-economic context and its impact on patients' health, (3) TM staff anecdotally report important potential impacts on patient health, and (4) integrating TM into primary care practices needs to be planned carefully. This qualitative study identified challenges and unexpected benefits that might inform future efforts. Communication and integration between the TM agency and the practice, including the designation of a point person within the office to coordinate TM and help address the broader contextual needs of patients, are important considerations for future implementation. The role of the TM nurse in developing trust with patients and uncovering the social and economic context within which patients manage their diabetes was an unexpected benefit.

Mapping chromatic pathways in the Drosophila visual system.

PubMed

Lin, Tzu-Yang; Luo, Jiangnan; Shinomiya, Kazunori; Ting, Chun-Yuan; Lu, Zhiyuan; Meinertzhagen, Ian A; Lee, Chi-Hon

2016-02-01

In Drosophila, color vision and wavelength-selective behaviors are mediated by the compound eye's narrow-spectrum photoreceptors R7 and R8 and their downstream medulla projection (Tm) neurons Tm5a, Tm5b, Tm5c, and Tm20 in the second optic neuropil or medulla. These chromatic Tm neurons project axons to a deeper optic neuropil, the lobula, which in insects has been implicated in processing and relaying color information to the central brain. The synaptic targets of the chromatic Tm neurons in the lobula are not known, however. Using a modified GFP reconstitution across synaptic partners (GRASP) method to probe connections between the chromatic Tm neurons and 28 known and novel types of lobula neurons, we identify anatomically the visual projection neurons LT11 and LC14 and the lobula intrinsic neurons Li3 and Li4 as synaptic targets of the chromatic Tm neurons. Single-cell GRASP analyses reveal that Li4 receives synaptic contacts from over 90% of all four types of chromatic Tm neurons, whereas LT11 is postsynaptic to the chromatic Tm neurons, with only modest selectivity and at a lower frequency and density. To visualize synaptic contacts at the ultrastructural level, we develop and apply a "two-tag" double-labeling method to label LT11's dendrites and the mitochondria in Tm5c's presynaptic terminals. Serial electron microscopic reconstruction confirms that LT11 receives direct contacts from Tm5c. This method would be generally applicable to map the connections of large complex neurons in Drosophila and other animals. © 2015 Wiley Periodicals, Inc.

Trimeric transmembrane domain interactions in paramyxovirus fusion proteins: roles in protein folding, stability, and function.

PubMed

Smith, Everett Clinton; Smith, Stacy E; Carter, James R; Webb, Stacy R; Gibson, Kathleen M; Hellman, Lance M; Fried, Michael G; Dutch, Rebecca Ellis

2013-12-13

Paramyxovirus fusion (F) proteins promote membrane fusion between the viral envelope and host cell membranes, a critical early step in viral infection. Although mutational analyses have indicated that transmembrane (TM) domain residues can affect folding or function of viral fusion proteins, direct analysis of TM-TM interactions has proved challenging. To directly assess TM interactions, the oligomeric state of purified chimeric proteins containing the Staphylococcal nuclease (SN) protein linked to the TM segments from three paramyxovirus F proteins was analyzed by sedimentation equilibrium analysis in detergent and buffer conditions that allowed density matching. A monomer-trimer equilibrium best fit was found for all three SN-TM constructs tested, and similar fits were obtained with peptides corresponding to just the TM region of two different paramyxovirus F proteins. These findings demonstrate for the first time that class I viral fusion protein TM domains can self-associate as trimeric complexes in the absence of the rest of the protein. Glycine residues have been implicated in TM helix interactions, so the effect of mutations at Hendra F Gly-508 was assessed in the context of the whole F protein. Mutations G508I or G508L resulted in decreased cell surface expression of the fusogenic form, consistent with decreased stability of the prefusion form of the protein. Sedimentation equilibrium analysis of TM domains containing these mutations gave higher relative association constants, suggesting altered TM-TM interactions. Overall, these results suggest that trimeric TM interactions are important driving forces for protein folding, stability and membrane fusion promotion.

Trimeric Transmembrane Domain Interactions in Paramyxovirus Fusion Proteins

PubMed Central

Smith, Everett Clinton; Smith, Stacy E.; Carter, James R.; Webb, Stacy R.; Gibson, Kathleen M.; Hellman, Lance M.; Fried, Michael G.; Dutch, Rebecca Ellis

2013-01-01

Paramyxovirus fusion (F) proteins promote membrane fusion between the viral envelope and host cell membranes, a critical early step in viral infection. Although mutational analyses have indicated that transmembrane (TM) domain residues can affect folding or function of viral fusion proteins, direct analysis of TM-TM interactions has proved challenging. To directly assess TM interactions, the oligomeric state of purified chimeric proteins containing the Staphylococcal nuclease (SN) protein linked to the TM segments from three paramyxovirus F proteins was analyzed by sedimentation equilibrium analysis in detergent and buffer conditions that allowed density matching. A monomer-trimer equilibrium best fit was found for all three SN-TM constructs tested, and similar fits were obtained with peptides corresponding to just the TM region of two different paramyxovirus F proteins. These findings demonstrate for the first time that class I viral fusion protein TM domains can self-associate as trimeric complexes in the absence of the rest of the protein. Glycine residues have been implicated in TM helix interactions, so the effect of mutations at Hendra F Gly-508 was assessed in the context of the whole F protein. Mutations G508I or G508L resulted in decreased cell surface expression of the fusogenic form, consistent with decreased stability of the prefusion form of the protein. Sedimentation equilibrium analysis of TM domains containing these mutations gave higher relative association constants, suggesting altered TM-TM interactions. Overall, these results suggest that trimeric TM interactions are important driving forces for protein folding, stability and membrane fusion promotion. PMID:24178297

LibQUAL+[TM]: A Methodological Suite; Reliability and Structure of LibQUAL+[TM] Scores: Measuring Perceived Library Service Quality; Score Norms for Improving Library Service Quality: A LibQUAL+[TM] Study; ARL Index and Other Validity Correlates of LibQUAL+[TM] Scores.

ERIC Educational Resources Information Center

Heath, Fred M.; Thompson, Bruce; Cook, Colleen; Thompson, Russel L.; Kyrillidou, Martha

2002-01-01

Includes four articles that discuss LibQUAL+[TM], a collaborative effort of the Association of Research Libraries and Texas A&M University responding to the need for greater accountability in measuring the delivery of library services to research library users. Discusses the reliability of LibQUAL+[TM] scores in measuring perceived library…

Response of the human tympanic membrane to transient acoustic and mechanical stimuli: Preliminary results.

PubMed

Razavi, Payam; Ravicz, Michael E; Dobrev, Ivo; Cheng, Jeffrey Tao; Furlong, Cosme; Rosowski, John J

2016-10-01

The response of the tympanic membrane (TM) to transient environmental sounds and the contributions of different parts of the TM to middle-ear sound transmission were investigated by measuring the TM response to global transients (acoustic clicks) and to local transients (mechanical impulses) applied to the umbo and various locations on the TM. A lightly-fixed human temporal bone was prepared by removing the ear canal, inner ear, and stapes, leaving the incus, malleus, and TM intact. Motion of nearly the entire TM was measured by a digital holography system with a high speed camera at a rate of 42 000 frames per second, giving a temporal resolution of <24 μs for the duration of the TM response. The entire TM responded nearly instantaneously to acoustic transient stimuli, though the peak displacement and decay time constant varied with location. With local mechanical transients, the TM responded first locally at the site of stimulation, and the response spread approximately symmetrically and circumferentially around the umbo and manubrium. Acoustic and mechanical transients provide distinct and complementary stimuli for the study of TM response. Spatial variations in decay and rate of spread of response imply local variations in TM stiffness, mass, and damping. Copyright © 2016 Elsevier B.V. All rights reserved.

Localizome: a server for identifying transmembrane topologies and TM helices of eukaryotic proteins utilizing domain information

PubMed Central

Lee, Sunghoon; Lee, Byungwook; Jang, Insoo; Kim, Sangsoo; Bhak, Jong

2006-01-01

The Localizome server predicts the transmembrane (TM) helix number and TM topology of a user-supplied eukaryotic protein and presents the result as an intuitive graphic representation. It utilizes hmmpfam to detect the presence of Pfam domains and a prediction algorithm, Phobius, to predict the TM helices. The results are combined and checked against the TM topology rules stored in a protein domain database called LocaloDom. LocaloDom is a curated database that contains TM topologies and TM helix numbers of known protein domains. It was constructed from Pfam domains combined with Swiss-Prot annotations and Phobius predictions. The Localizome server corrects the combined results of the user sequence to conform to the rules stored in LocaloDom. Compared with other programs, this server showed the highest accuracy for TM topology prediction: for soluble proteins, the accuracy and coverage were 99 and 75%, respectively, while for TM protein domain regions, they were 96 and 68%, respectively. With a graphical representation of TM topology and TM helix positions with the domain units, the Localizome server is a highly accurate and comprehensive information source for subcellular localization for soluble proteins as well as membrane proteins. The Localizome server can be found at . PMID:16845118

Response of the human tympanic membrane to transient acoustic and mechanical stimuli: Preliminary results

PubMed Central

Razavi, Payam; Ravicz, Michael E.; Dobrev, Ivo; Cheng, Jeffrey Tao; Furlong, Cosme; Rosowski, John J.

2016-01-01

The response of the tympanic membrane (TM) to transient environmental sounds and the contributions of different parts of the TM to middle-ear sound transmission were investigated by measuring the TM response to global transients (acoustic clicks) and to local transients (mechanical impulses) applied to the umbo and various locations on the TM. A lightly-fixed human temporal bone was prepared by removing the ear canal, inner ear, and stapes, leaving the incus, malleus, and TM intact. Motion of nearly the entire TM was measured by a digital holography system with a high speed camera at a rate of 42 000 frames per second, giving a temporal resolution of <24 μs for the duration of the TM response. The entire TM responded nearly instantaneously to acoustic transient stimuli, though the peak displacement and decay time constant varied with location. With local mechanical transients, the TM responded first locally at the site of stimulation, and the response spread approximately symmetrically and circumferentially around the umbo and manubrium. Acoustic and mechanical transients provide distinct and complementary stimuli for the study of TM response. Spatial variations in decay and rate of spread of response imply local variations in TM stiffness, mass, and damping. PMID:26880098

Impact of Maple(TM) on the design, instruction and performance in an undergraduate physics mathematical methods course

NASA Astrophysics Data System (ADS)

Runge, Alan Paul

1997-10-01

A traditional undergraduate physics course on mathematical methods has been redesigned to incorporate the use of Maplesp{sc {TM}}, a computer algebra program, during all aspects of the course. Topics covered were: complex number theory; series approximations; matrix theory; partial differentiation; vector algebra; and vector calculus. Five undergraduate students were enrolled, from sophomore to senior in academic class standing. A qualitative case study methodology was used to describe the changes in the course design resulting from the incorporation of Maplesp{sc {TM}} and their impact on the instruction of the course, and to determine the effects on the students' learning and development of problem solving skills in physics using Maplesp{sc {TM}} as a problem solving tool. The impact of using Maplesp{sc {TM}} on the number and types of interactions is presented. The entire semester long course was included in this study. Each class session is described in detail. Examples of the Maplesp{sc {TM}} materials used are given. The use of the Maplesp{sc {TM}} program was allowed on all homework and exams with each student having their own computer during class. Constraints were made so that the assessment emphasis remained on the mathematics and the conceptual understanding of the problem solving methods. All of the students demonstrated some level of proficiency in using Maplesp{TM} to solve the assigned problems. Strategies for effectively using Maplesp{TM} were presented and were individualized by the students. The students reported positive and negative impacts of using Maplesp{sc {TM}}. All of the students satisfactorily completed the course requirements, receiving final course grades from B to A+. All of them continued to voluntarily use Maplesp{sc {TM}} during the following semester. Instructional methods used included various lecture techniques without Maplesp{sc {TM}} assistance, lectures and demonstrations using only Maplesp{sc {TM}}, and student tasks assigned in class worked with the aid of Maplesp{sc {TM}}. Maplesp{sc {TM}} was used in one of these aspects in all but 3, out of 45, class periods. The use of Maplesp{sc {TM}} constituted about half of the overall class time.

Directory of Organizational Technical Report Acronym Codes (DOTRAC)

DTIC Science & Technology

1994-07-01

TM - Technical memo report........................................................... TMR- Technical news bulletin...BETHESDA 418182 MD DTRC- TM -12 DAVID TAYLOR RESEARCH CENTER BETHESDA 418631 MD SHIP SYSTEMS INTEGRATION DEPT DTRC- TM -14 DAVID TAYLOR RESEARCH CENTER...BETHESDA 419277 MD SHIP ELECTROMAGNETIC SIGNATURES DEPT DTRC- TM -15 DAVID TAYLOR RESEARCH CENTER BETHESDA 418173 MD SHIP HYDROMECHANICS DEPT DTRC- TM -16 DAVID

Three-Dimensional High-Order Spectral Volume Method for Solving Maxwell's Equations on Unstructured Grids

NASA Technical Reports Server (NTRS)

Liu, Yen; Vinokur, Marcel; Wang, Z. J.

2004-01-01

A three-dimensional, high-order, conservative, and efficient discontinuous spectral volume (SV) method for the solutions of Maxwell's equations on unstructured grids is presented. The concept of discontinuous 2nd high-order loca1 representations to achieve conservation and high accuracy is utilized in a manner similar to the Discontinuous Galerkin (DG) method, but instead of using a Galerkin finite-element formulation, the SV method is based on a finite-volume approach to attain a simpler formulation. Conventional unstructured finite-volume methods require data reconstruction based on the least-squares formulation using neighboring cell data. Since each unknown employs a different stencil, one must repeat the least-squares inversion for every cell at each time step, or to store the inversion coefficients. In a high-order, three-dimensional computation, the former would involve impractically large CPU time, while for the latter the memory requirement becomes prohibitive. In the SV method, one starts with a relatively coarse grid of triangles or tetrahedra, called spectral volumes (SVs), and partition each SV into a number of structured subcells, called control volumes (CVs), that support a polynomial expansion of a desired degree of precision. The unknowns are cell averages over CVs. If all the SVs are partitioned in a geometrically similar manner, the reconstruction becomes universal as a weighted sum of unknowns, and only a few universal coefficients need to be stored for the surface integrals over CV faces. Since the solution is discontinuous across the SV boundaries, a Riemann solver is thus necessary to maintain conservation. In the paper, multi-parameter and symmetric SV partitions, up to quartic for triangle and cubic for tetrahedron, are first presented. The corresponding weight coefficients for CV face integrals in terms of CV cell averages for each partition are analytically determined. These discretization formulas are then applied to the integral form of the Maxwell equations. All numerical procedures for outer boundary, material interface, zonal interface, and interior SV face are unified with a single characteristic formulation. The load balancing in a massive parallel computing environment is therefore easier to achieve. A parameter is introduced in the Riemann solver to control the strength of the smoothing term. Important aspects of the data structure and its effects to communication and the optimum use of cache memory are discussed. Results will be presented for plane TE and TM waves incident on a perfectly conducting cylinder for up to fifth order of accuracy, and a plane wave incident on a perfectly conducting sphere for up to fourth order of accuracy. Comparisons are made with exact solutions for these cases.

A novel nomenclature to classify parathyroid adenomas.

PubMed

Perrier, Nancy D; Edeiken, Beth; Nunez, Rodolfo; Gayed, Isis; Jimenez, Camilo; Busaidy, Naifa; Potylchansky, Elena; Kee, Spencer; Vu, Thinh

2009-03-01

A uniform and reliable description of the exact locations of adenomatous parathyroid glands is necessary for accurate communications between surgeons and other specialists. We developed a nomenclature that provides a precise means of communicating the most frequently encountered parathyroid adenoma locations. This classification scheme is based on the anatomic detail provided by imaging and can be used in radiology reports, operative records, and pathology reports. It is based on quadrants and anterior-posterior depth relative to the course of the recurrent laryngeal nerve and the thyroid parenchyma. The system uses the letters A-G to describe exact gland locations. A type A parathyroid gland is a gland that originates from a superior pedicle, lateral to the recurrent laryngeal nerve compressed within the capsule of the thyroid parenchyma. A type B gland is a superior gland that has fallen posteriorly into the tracheoesophageal groove and is in the same cross-sectional plane as the superior portion of the thyroid parenchyma. A type C gland is a gland that has fallen posteriorly into the tracheoesophageal groove and on a cross-sectional view lies at the level of or below the inferior pole of the thyroid gland. A type D gland lies in the midregion of the posterior surface of the thyroid parenchyma, near the junction of the recurrent laryngeal nerve and the inferior thyroid artery or middle thyroidal vein; because of this location, dissection is difficult. A type E gland is an inferior gland close to the inferior pole of the thyroid parenchyma, lying in the lateral plane with the thyroid parenchyma and anterior half of the trachea. A type F gland is an inferior gland that has descended (fallen) into the thyrothymic ligament or superior thymus; it may appear to be "ectopic" or within the superior mediastinum. An anterior-posterior view shows the type F gland to be anterior to the trachea. A type G gland is a rare, truly intrathyroidal parathyroid gland. A reproducible nomenclature can provide a means of consistent communication about parathyroid adenoma location. If uniformly adopted, it has the potential to reliably communicate exact gland location without lengthy descriptions. This system may be beneficial for surgical planning as well as operative and pathology reporting.

Laser Trabeculoplasty Induces Changes in the Trabecular Meshwork Glycoproteome: A pilot study

PubMed Central

Amelinckx, Adriana; Castello, Maria; Arrieta-Quintero, Esdras; Lee, Tinthu; Salas, Nelson; Hernandez, Eleut; Lee, Richard K.; Bhattacharya, Sanjoy K.; Parel, Jean-Marie A

2009-01-01

Laser trabeculoplasty (LT) is a commonly used modality of treatment for glaucoma. The mechanism by which LT lowers the intraocular pressure (IOP) is unknown. Using cat eyes, selective laser trabeculoplasty (SLT) with a Q-switched frequency doubled Nd:YAG laser was used to treat the trabecular meshwork (TM). Laser treated TM was then subjected to proteomic analysis for detection of molecular changes and histological analysis for the detection of structural and protein expression patterns. In addition, the protein glycosylation patterns of laser treated and non-treated TM was assessed and differentially glycosylated proteins were proteomically identified. SLT laser treatment to the TM resulted in elevated glycosylation levels compared to non-lasered TM. TM laser treatment also resulted in protein expression levels changes of several proteins. Elevated levels of biglycan, keratocan and prolargin were detected in laser treated TM compared to non-lasered controls. Further investigation is anticipated to provide insight into how glycosylation changes affect TM proteins and TM regulation of aqueous outflow in response to laser trabeculoplasty. PMID:19432485

Laser trabeculoplasty induces changes in the trabecular meshwork glycoproteome: a pilot study.

PubMed

Amelinckx, Adriana; Castello, Maria; Arrieta-Quintero, Esdras; Lee, Tinthu; Salas, Nelson; Hernandez, Eleut; Lee, Richard K; Bhattacharya, Sanjoy K; Parel, Jean-Marie A

2009-07-01

Laser trabeculoplasty (LT) is a commonly used modality of treatment for glaucoma. The mechanism by which LT lowers the intraocular pressure (IOP) is unknown. With the use of cat eyes, selective laser trabeculoplasty (SLT) with a Q-switched frequency doubled Nd:YAG laser was used to treat the trabecular meshwork (TM). Laser treated TM was then subjected to proteomic analysis for detection of molecular changes and histological analysis for the detection of structural and protein expression patterns. In addition, the protein glycosylation patterns of laser treated and nontreated TM was assessed and differentially glycosylated proteins were proteomically identified. SLT laser treatment to the TM resulted in elevated glycosylation levels compared to nonlasered TM. TM laser treatment also resulted in protein expression levels changes of several proteins. Elevated levels of biglycan, keratocan and prolargin were detected in laser treated TM compared to nonlasered controls. Further investigation is anticipated to provide insight into how glycosylation changes affect TM proteins and TM regulation of aqueous outflow in response to laser trabeculoplasty.

Studies of tin-transition metal-carbon and tin-cobalt-transition metal-carbon negative electrode materials prepared by mechanical attrition

NASA Astrophysics Data System (ADS)

Ferguson, P. P.; Martine, M. L.; George, A. E.; Dahn, J. R.

Samples of Sn 30TM 30C 40 and of Sn 30Co 15TM 15C 40, with TM = 3d transition metals, were prepared by vertical-axis attritor milling. The structure and performance of these samples were studied by X-ray diffraction (XRD) and by electrochemical testing. The XRD patterns of Sn 30TM 30C 40 show an amorphous-like diffraction pattern only for the sample with TM = Co. The other prepared samples show broadened Bragg peaks of their main starting material, along with an amorphous-like background, even after 32 h of milling. Samples with TM = Co and TM = Ni show stable differential capacity versus potential plots and stable cycling for at least 100 cycles with reversible capacities of 425 and 250 mAh g -1, respectively. All samples prepared with 15 at.% Co show good capacity retention for at least 100 cycles ranging from 270 mAh g -1 for samples with TM = Ni to 500 mAh g -1 for samples with TM = Ti. The differential capacity versus potential plots for all the prepared Sn 30Co 15TM 15C 40 samples show similar structure to that of Sn 30Co 30C 40 except when TM = Cu. This shows the possibility of preparing tin-based negative electrode materials using a combination of cobalt and TM, especially if one looks to reduce the cobalt content.

Thrombomodulin regulates monocye differentiation via PKCδ and ERK1/2 pathway in vitro and in atherosclerotic artery

PubMed Central

Tsai, Chien-Sung; Lin, Yi-Wen; Huang, Chun-Yao; Shih, Chun-Min; Tsai, Yi-Ting; Tsao, Nai-Wen; Lin, Chin-Sheng; Shih, Chun-Che; Jeng, Hellen; Lin, Feng-Yen

2016-01-01

Thrombomodulin (TM) modulates the activation of protein C and coagulation. Additionally, TM regulates monocyte migration and inflammation. However, its role on monocyte differentiation is still unknown. We investigated the effects of TM on monocyte differentiation. First, we found that TM was increased when THP-1 cells were treated with phorbol-12-myristate-13-acetate (PMA). Overexpression of TM enhanced the macrophage markers, CD14 and CD68 expression in PMA-induced THP-1. TM siRNA depressed the PMA-induced increase of p21Cip1/WAF1 via ERK1/2-NF-kB p65 signaling. TM regulated cytoskeletal reorganization via its interaction with paxillin, cofilin, LIMK1, and PYK2. In addition, PMA-induced p21Cip1/WAF1 expression, CD14-positive cell labeling intensity and ERK1/2 phosphorylation were markedly inhibited when protein kinase C-δ (PKCδ) was knocked down. We identified that TM directly interacts with PKCδ. PKCδ was highly expressed in human atherosclerotic arteries and colocalized with TM in CD68-positive infiltrated macrophages of plaques, indicating that the coordination between TM and PKCδ in macrophages participated in atherogenesis. TM may act as a scaffold for PKCδ docking, which keeps PKCδ in the region close to the monocyte membrane to promote the activation of ERK1/2. Taken together, our findings suggest that TM-PKCδ interaction may contribute to cardiovascular disorders by affecting monocye differentiation, which may develop future therapeutic applications. PMID:27910925

Tethys Tops Saturn

NASA Image and Video Library

2016-07-11

An illusion of perspective, Saturn's moon Tethys seems to hang above the planet's north pole in this view from NASA's Cassini spacecraft. Tethys (660 miles or 1,062 kilometers across) is actually farther away than Saturn in this image. Lacking visual clues about distance, our brains place the moon above Saturn's north pole. Tethys, like all of Saturn's major moons and its ring system, orbits almost exactly in the planet's equatorial plane. This view looks toward the sunlit side of the rings from about 17 degrees above the ring plane. The image was taken with the Cassini spacecraft's wide-angle camera on Jan. 26, 2015 using a spectral filter which preferentially admits wavelengths of near-infrared light centered at 752 nanometers. The view was acquired at a distance of approximately 2.1 million miles (3.4 million kilometers) from Saturn. Image scale on Saturn is 120 miles (200 kilometers) per pixel. Tethys has been brightened by a factor of three relative to Saturn to enhance its visibility. http://photojournal.jpl.nasa.gov/catalog/PIA20488

Partial restoration of chiral symmetry in a confining string

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kharzeev, Dmitri E.; Loshaj, F.

2014-08-01

Here, we attempt to describe the interplay of confinement and chiral symmetry breaking in QCD by using the string model. We argue that in the quasi-Abelian picture of confinement based on the condensation of magnetic monopoles and the dual Meissner effect, the world sheet dynamics of the confining string can be effectively described by the 1+1 dimensional massless electrodynamics, which is exactly soluble. The transverse plane distribution of the chromoelectric field stretched between the quark and antiquark sources can then be attributed to the fluctuations in the position of the string. The dependence of the chiral condensate in the stringmore » on the (chromo-)electric field can be evaluated analytically, and is determined by the chiral anomaly and the θ-vacuum structure. Moreover, our picture allows us to predict the distribution of the chiral condensate in the plane transverse to the axis connecting the quark and antiquark. This prediction is compared to the lattice QCD results; a good agreement is found.« less

Thrust law effects on the long-period modes of aerospace craft

NASA Technical Reports Server (NTRS)

Markopoulos, Nikos; Mease, Kenneth D.; Vinh, Nguyen X.

1989-01-01

An analytical study is presented of the longitudinal long-period dynamics of an aerospace craft in a nearly circular orbit, with a thrust law depending arbitrarily on the speed and altitude. A plane of engine possibilities is first defined, with points corresponding to propulsion systems having prescribed thrust slopes with respect to speed and altitude. Approximate expressions for the characteristic roots and times are obtained by first identifying a small quantity in the coefficients of the characteristic equation, and then expanding in a perturbation series about the origin of the plane of engine possibilities, for which the solution is always known. These expressions agree very well with the exact solutions over a wide range of altitudes and thrust laws. The period of the oscillatory translational mode (phugoid) is found to be independent to first order of the thrust law, generalizing results found by previous investigators for specific thrust laws. The results apply to the speed range from hypersonic to orbital.

A homogenization approach for the effective drained viscoelastic properties of 2D porous media and an application for cortical bone.

PubMed

Nguyen, Sy-Tuan; Vu, Mai-Ba; Vu, Minh-Ngoc; To, Quy-Dong

2018-02-01

Closed-form solutions for the effective rheological properties of a 2D viscoelastic drained porous medium made of a Generalized Maxwell viscoelastic matrix and pore inclusions are developed and applied for cortical bone. The in-plane (transverse) effective viscoelastic bulk and shear moduli of the Generalized Maxwell rheology of the homogenized medium are expressed as functions of the porosity and the viscoelastic properties of the solid phase. When deriving these functions, the classical inverse Laplace-Carson transformation technique is avoided, due to its complexity, by considering the short and long term approximations. The approximated results are validated against exact solutions obtained from the inverse Laplace-Carson transform for a simple configuration when the later is available. An application for cortical bone with assumption of circular pore in the transverse plane shows that the proposed approximation fit very well with experimental data. Copyright © 2017 Elsevier Ltd. All rights reserved.

Free-form surface design method for a collimator TIR lens.

PubMed

Tsai, Chung-Yu

2016-04-01

A free-form (FF) surface design method is proposed for a general axial-symmetrical collimator system consisting of a light source and a total internal reflection lens with two coupled FF boundary surfaces. The profiles of the boundary surfaces are designed using a FF surface construction method such that each incident ray is directed (refracted and reflected) in such a way as to form a specified image pattern on the target plane. The light ray paths within the system are analyzed using an exact analytical model and a skew-ray tracing approach. In addition, the validity of the proposed FF design method is demonstrated by means of ZEMAX simulations. It is shown that the illumination distribution formed on the target plane is in good agreement with that specified by the user. The proposed surface construction method is mathematically straightforward and easily implemented in computer code. As such, it provides a useful tool for the design and analysis of general axial-symmetrical optical systems.

FAST TRACK COMMUNICATION: Superintegrability of the Tremblay-Turbiner-Winternitz quantum Hamiltonians on a plane for odd k

NASA Astrophysics Data System (ADS)

Quesne, C.

2010-02-01

In a recent communication paper by Tremblay et al (2009 J. Phys. A: Math. Theor. 42 205206), it has been conjectured that for any integer value of k, some novel exactly solvable and integrable quantum Hamiltonian Hk on a plane is superintegrable and that the additional integral of motion is a 2kth-order differential operator Y2k. Here we demonstrate the conjecture for the infinite family of Hamiltonians Hk with odd k >= 3, whose first member corresponds to the three-body Calogero-Marchioro-Wolfes model after elimination of the centre-of-mass motion. Our approach is based on the construction of some D2k-extended and invariant Hamiltonian {\\cal H}_k, which can be interpreted as a modified boson oscillator Hamiltonian. The latter is then shown to possess a D2k-invariant integral of motion {\\cal Y}_{2k}, from which Y2k can be obtained by projection in the D2k identity representation space.

Computation of the area in the discrete plane: Green's theorem revisited

NASA Astrophysics Data System (ADS)

Chalifour, Alain; Nouboud, Fathallah; Voisin, Yvon

2017-11-01

The detection of the contour of a binary object is a common problem; however, the area of a region, and its moments, can be a significant parameter. In several metrology applications, the area of planar objects must be measured. The area is obtained by counting the pixels inside the contour or using a discrete version of Green's formula. Unfortunately, we obtain the area enclosed by the polygonal line passing through the centers of the pixels along the contour. We present a modified version of Green's theorem in the discrete plane, which allows for the computation of the exact area of a two-dimensional region in the class of polyominoes. Penalties are introduced and associated with each successive pair of Freeman displacements along the contour in an eight-connectivity system. The proposed equation is shown to be true and properties of the equation related to the topology of the regions are presented. The proposed approach is adapted for faster computation than the combinatorial approach proposed in the literature.

Towards a PTAS for the generalized TSP in grid clusters

NASA Astrophysics Data System (ADS)

Khachay, Michael; Neznakhina, Katherine

2016-10-01

The Generalized Traveling Salesman Problem (GTSP) is a combinatorial optimization problem, which is to find a minimum cost cycle visiting one point (city) from each cluster exactly. We consider a geometric case of this problem, where n nodes are given inside the integer grid (in the Euclidean plane), each grid cell is a unit square. Clusters are induced by cells `populated' by nodes of the given instance. Even in this special setting, the GTSP remains intractable enclosing the classic Euclidean TSP on the plane. Recently, it was shown that the problem has (1.5+8√2+ɛ)-approximation algorithm with complexity bound depending on n and k polynomially, where k is the number of clusters. In this paper, we propose two approximation algorithms for the Euclidean GTSP on grid clusters. For any fixed k, both algorithms are PTAS. Time complexity of the first one remains polynomial for k = O(log n) while the second one is a PTAS, when k = n - O(log n).

Analytic treatment of charge cloud overlaps: an improvement of the tomographic atom probe efficiency

NASA Astrophysics Data System (ADS)

Bas, P.; Bostel, A.; Grancher, G.; Deconihout, B.; Blavette, D.

1996-03-01

Although reliable position and composition data are obtained with the Tomographic Atom Probe, the procedure of position calculation by charge centroiding fails when the detector receives two or more ions with close spaced positions and the same mass-to-charge ratio. As the charge clouds of the ions overlap, they form a unique charge pattern on the multianode detector. Only one atom is represented and its position is biased. In order to estimate real positions, we have developed a correction method. The spatial distribution of charges inside a cloud issued from one impact is modelled by a Gaussian law. The particular properties of the Gaussian enable the calculation of exact positions of the two impacts of the overlapped charge patterns and charges of corresponding clouds. The calculation may be generalized for more than two overlapped clouds. The method was tested on a plane-by-plane analysis of a fully ordered Cu 3Au alloy performed on a (100) pole.

Equilibrium configurations of the conducting liquid surface in a nonuniform electric field

NASA Astrophysics Data System (ADS)

Zubarev, N. M.; Zubareva, O. V.

2011-01-01

Possible equilibrium configurations of the free surface of a conducting liquid deformed by a nonuniform external electric field are investigated. The liquid rests on an electrode that has the shape of a dihedral angle formed by two intersecting equipotential half-planes (conducting wedge). It is assumed that the problem has plane symmetry: the surface is invariant under shift along the edge of the dihedral angle. A one-parametric family of exact solutions for the shape of the surface is found in which the opening angle of the region above the wedge serves as a parameter. The solutions are valid when the pressure difference between the inside and outside of the liquid is zero. For an arbitrary pressure difference, approximate solutions to the problem are constructed and it is demonstrated the approximation error is small. It is found that, when the potential difference exceeds a certain threshold value, equilibrium solutions are absent. In this case, the region occupied by the liquid disintegrates, the disintegration scenario depending on the opening angle.

Effective on-site Coulomb interaction and electron configurations in transition-metal complexes from constraint density functional theory

NASA Astrophysics Data System (ADS)

Nawa, Kenji; Nakamura, Kohji; Akiyama, Toru; Ito, Tomonori; Weinert, Michael

Effective on-site Coulomb interactions (Ueff) and electron configurations in the localized d and f orbitals of metal complexes in transition-metal oxides and organometallic molecules, play a key role in the first-principles search for the true ground-state. However, wide ranges of values in the Ueff parameter of a material, even in the same ionic state, are often reported. Here, we revisit this issue from constraint density functional theory (DFT) by using the full-potential linearized augmented plane wave method. The Ueff parameters for prototypical transition-metal oxides, TMO (TM =Mn, Fe, Co, Ni), were calculated by the second derivative of the total energy functional with respect to the d occupation numbers inside the muffin-tin (MT) spheres as a function of the sphere radius. We find that the calculated Ueff values depend significantly on the MT radius, with a variation of more than 3 eV when the MT radius changes from 2.0 to 2.7 a.u., but importantly an identical valence band structure can be produced in all the cases, with an approximate scaling of Ueff. This indicates that a simple transferability of the Ueff value among different calculation methods is not allowed. We further extend the constraint DFT to treat various electron configurations of the localized d-orbitals in organometallic molecules, TMCp2 (TM =Cr, Mn, Fe, Co, Ni), and find that the calculated Ueff values can reproduce the experimentally determined ground-state electron configurations.

Tunable all-angle negative refraction and photonic band gaps in two-dimensional plasma photonic crystals with square-like Archimedean lattices

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhang, Hai-Feng, E-mail: hanlor@163.com, E-mail: lsb@nuaa.edu.cn; Nanjing Artillery Academy, Nanjing 211132; Liu, Shao-Bin, E-mail: hanlor@163.com, E-mail: lsb@nuaa.edu.cn

In this paper, the tunable all-angle negative refraction and photonic band gaps (PBGs) in two types of two-dimensional (2D) plasma photonic crystals (PPCs) composed of homogeneous plasma and dielectric (GaAs) with square-like Archimedean lattices (ladybug and bathroom lattices) for TM wave are theoretically investigated based on a modified plane wave expansion method. The type-1 structure is dielectric rods immersed in the plasma background, and the complementary structure is named as type-2 PPCs. Theoretical simulations demonstrate that the both types of PPCs with square-like Archimedean lattices have some advantages in obtaining the higher cut-off frequency, the larger PBGs, more number ofmore » PBGs, and the relative bandwidths compared to the conventional square lattices as the filling factor or radius of inserted rods is same. The influences of plasma frequency and radius of inserted rod on the properties of PBGs for both types of PPCs also are discussed in detail. The calculated results show that PBGs can be manipulated by the parameters as mentioned above. The possibilities of all-angle negative refraction in such two types of PPCs at low bands also are discussed. Our calculations reveal that the all-angle negative phenomena can be observed in the first two TM bands, and the frequency range of all-angle negative refraction can be tuned by changing plasma frequency. Those properties can be used to design the optical switching and sensor.« less

Reliability and Validity of the Zephyr[TM] BioHarness[TM] to Measure Respiratory Responses to Exercise

ERIC Educational Resources Information Center

Hailstone, Jono; Kilding, Andrew E.

2011-01-01

The Zephyr[TM] BioHarness[TM] (Zephyr Technology, Auckland, New Zealand) is a wireless physiological monitoring system that has the ability to measure respiratory rate unobtrusively. However, the ability of the BioHarness[TM] to accurately and reproducibly determine respiratory rate across a range of intensities is currently unknown. The aim of…

Medical student appraisal: searching on smartphones.

PubMed

Khalifian, S; Markman, T; Sampognaro, P; Mitchell, S; Weeks, S; Dattilo, J

2013-01-01

The rapidly growing industry for mobile medical applications provides numerous smartphone resources designed for healthcare professionals. However, not all applications are equally useful in addressing the questions of early medical trainees. Three popular, free, mobile healthcare applications were evaluated along with a Google(TM) web search on both Apple(TM) and Android(TM) devices. Six medical students at a large academic hospital evaluated each application for a one-week period while on various clinical rotations. Google(TM) was the most frequently used search method and presented multimedia resources but was inefficient for obtaining clinical management information. Epocrates(TM) Pill ID feature was praised for its clinical utility. Medscape(TM) had the highest satisfaction of search and excelled through interactive educational features. Micromedex(TM) offered both FDA and off-label dosing for drugs. Google(TM) was the preferred search method for questions related to basic disease processes and multimedia resources, but was inadequate for clinical management. Caution should also be exercised when using Google(TM) in front of patients. Medscape(TM) was the most appealing application due to a broad scope of content and educational features relevant to medical trainees. Students should also be cognizant of how mobile technology may be perceived by their evaluators to avoid false impressions.

Spectroscopic and laser characterization of Yb,Tm:KLu(WO4)2 crystal

NASA Astrophysics Data System (ADS)

Loiko, P. A.; Serres, J. M.; Mateos, X.; Demesh, M. P.; Yasukevich, A. S.; Yumashev, K. V.; Petrov, V.; Griebner, U.; Aguiló, M.; Díaz, F.

2016-01-01

We report on a comprehensive spectroscopic and laser characterization of monoclinic Yb,Tm:KLu(WO4)2 crystals. Stimulated-emission cross-section spectra corresponding to the 3F4 → 3H6 transition of Tm3+ ions are determined. The radiative lifetime of the 3F4 state of Tm3+ ions is 0.82 ms. The maximum Yb3+ → Tm3+ energy transfer efficiency is 83.9% for 5 at.% Yb - 8 at.% Tm doping. The fractional heat loading for Yb,Tm:KLu(WO4)2 is 0.45 ± 0.05. Using a hemispherical cavity and 5 at.% Yb - 6 at.% Tm doped crystal, a maximum CW power of 227 mW is achieved at 1.983-2.011 μm with a maximum slope efficiency η = 14%. In the microchip laser set-up, the highest slope efficiency is 20% for a 5 at.% Yb- 8 at.% Tm doped crystal with a maximum output power of 201 mW at 1.99-2.007 μm. Operation of Yb,Tm:KLu(WO4)2 as a vibronic laser emitting at 2.081-2.093 μm is also demonstrated.

Anaysis of the quality of image data required by the LANDSAT-4 Thematic Mapper and Multispectral Scanner. [agricultural and forest cover types in California

NASA Technical Reports Server (NTRS)

Colwell, R. N. (Principal Investigator)

1984-01-01

The spatial, geometric, and radiometric qualities of LANDSAT 4 thematic mapper (TM) and multispectral scanner (MSS) data were evaluated by interpreting, through visual and computer means, film and digital products for selected agricultural and forest cover types in California. Multispectral analyses employing Bayesian maximum likelihood, discrete relaxation, and unsupervised clustering algorithms were used to compare the usefulness of TM and MSS data for discriminating individual cover types. Some of the significant results are as follows: (1) for maximizing the interpretability of agricultural and forest resources, TM color composites should contain spectral bands in the visible, near-reflectance infrared, and middle-reflectance infrared regions, namely TM 4 and TM % and must contain TM 4 in all cases even at the expense of excluding TM 5; (2) using enlarged TM film products, planimetric accuracy of mapped poins was within 91 meters (RMSE east) and 117 meters (RMSE north); (3) using TM digital products, planimetric accuracy of mapped points was within 12.0 meters (RMSE east) and 13.7 meters (RMSE north); and (4) applying a contextual classification algorithm to TM data provided classification accuracies competitive with Bayesian maximum likelihood.

Estimating Human Trabecular Meshwork Stiffness by Numerical Modeling and Advanced OCT Imaging.

PubMed

Wang, Ke; Johnstone, Murray A; Xin, Chen; Song, Shaozhen; Padilla, Steven; Vranka, Janice A; Acott, Ted S; Zhou, Kai; Schwaner, Stephen A; Wang, Ruikang K; Sulchek, Todd; Ethier, C Ross

2017-09-01

The purpose of this study was to estimate human trabecular meshwork (hTM) stiffness, thought to be elevated in glaucoma, using a novel indirect approach, and to compare results with direct en face atomic force microscopy (AFM) measurements. Postmortem human eyes were perfused to measure outflow facility and identify high- and low-flow regions (HF, LF) by tracer. Optical coherence tomography (OCT) images were obtained as Schlemm's canal luminal pressure was directly manipulated. TM stiffness was deduced by an inverse finite element modeling (FEM) approach. A series of AFM forcemaps was acquired along a line traversing the anterior angle on a radially cut flat-mount corneoscleral wedge with TM facing upward. The elastic modulus of normal hTM estimated by inverse FEM was 70 ± 20 kPa (mean ± SD), whereas glaucomatous hTM was slightly stiffer (98 ± 19 kPa). This trend was consistent with TM stiffnesses measured by AFM: normal hTM stiffness = 1.37 ± 0.56 kPa, which was lower than glaucomatous hTM stiffness (2.75 ± 1.19 kPa). None of these differences were statistically significant. TM in HF wedges was softer than that in LF wedges for both normal and glaucomatous eyes based on the inverse FEM approach but not by AFM. Outflow facility was significantly correlated with TM stiffness estimated by FEM in six human eyes (P = 0.018). TM stiffness is higher, but only modestly so, in glaucomatous patients. Outflow facility in both normal and glaucomatous human eyes appears to associate with TM stiffness. This evidence motivates further studies to investigate factors underlying TM biomechanical property regulation.

Cross talk between the TM4SF5/focal adhesion kinase and the interleukin-6/STAT3 pathways promotes immune escape of human liver cancer cells.

PubMed

Ryu, Jihye; Kang, Minkyung; Lee, Mi-Sook; Kim, Hye-Jin; Nam, Seo Hee; Song, Haeng Eun; Lee, Doohyung; Lee, Jung Weon

2014-08-01

TM4SF5 overexpressed in hepatocellular carcinoma activates focal adhesion kinase (FAK) during tumor cell migration. However, it remains unknown how TM4SF5 in hepatocellular carcinoma cells compromises with immune actions initiated by extracellular cytokines. Normal and cancerous hepatocytes with or without TM4SF5 expression were analyzed for the effects of cytokine signaling activity on TM4SF5/FAK signaling and metastatic potential. We found that interleukin-6 (IL-6) was differentially expressed in hepatocytes depending on cancerous malignancy and TM4SF5 expression. IL-6 treatment activated FAK and STAT3 and enhanced focal adhesion (FA) formation in TM4SF5-null cells, but it decreased TM4SF5-dependent FAK activity and FA formation in SNU761-TM4SF5 cells. STAT3 suppression abolished the IL-6-mediated effects in normal Chang cells, but it did not recover the TM4SF5-dependent FAK activity that was inhibited by IL-6 treatment in cancerous SNU761-TM4SF5 cells. In addition, modulation of FAK activity did not change the IL-6-mediated STAT3 activity in either the Chang or SNU761 cell system. TM4SF5 expression in SNU761 cells caused invasive extracellular matrix degradation negatively depending on IL-6/IL-6 receptor (IL-6R) signaling. Thus, it is likely that hepatic cancer cells adopt TM4SF5-dependent FAK activation and metastatic potential by lowering IL-6 expression and avoiding its immunological action through the IL-6-STAT3 pathway. Copyright © 2014, American Society for Microbiology. All Rights Reserved.

Location of the β4 transmembrane helices in the BK potassium channel

PubMed Central

Wu, Roland S.; Chudasama, Neelesh; Zakharov, Sergey I.; Doshi, Darshan; Motoike, Howard; Liu, Guoxia; Yao, Yongneng; Niu, Xiaowei; Deng, Shi-Xian; Landry, Donald W.; Karlin, Arthur; Marx, Steven O.

2009-01-01

Large-conductance, voltage- and Ca2+-gated potassium (BK) channels control excitability in a number of cell types. BK channels are composed of α subunits, which contain the voltage-sensor domains and the Ca2+- sensor domains, and form the pore, and often one of four types of β subunits, which modulate the channel in a cell-specific manner. β4 is expressed in neurons throughout the brain. Deletion of β4 in mice causes temporal lobe epilepsy. Compared to channels composed of α alone, channels composed of α and β4 activate and deactivate more slowly. We inferred the locations of the two β4 transmembrane (TM) helices, TM1 and TM2, relative to the seven αTM helices, S0-S6, from the extent of disulfide bond formation between cysteines substituted in the extracellular flanks of these TM helices. We found that β4 TM2 is close to α S0 and that β4 TM1 is close to both α S1 and S2. At least at their extracellular ends, TM1 and TM2 are not close to S3 through S6. In six of eight of the most highly crosslinked cysteine pairs, four crosslinks from TM2 to S0 and one each from TM1 to S1 and S2 had small effects on the V50 and on the rates of activation and deactivation. That disulfide crosslinking caused only small functional perturbations is consistent with the proximity of the extracellular ends of TM2 to S0 and of TM1 to S1 and to S2, in both the open and closed states. PMID:19571123

Perception of socket alignment perturbations in amputees with transtibial prostheses.

PubMed

Boone, David A; Kobayashi, Toshiki; Chou, Teri G; Arabian, Adam K; Coleman, Kim L; Orendurff, Michael S; Zhang, Ming

2012-01-01

A person with amputation's subjective perception is the only tool available to describe fit and comfort to a prosthetist. However, few studies have investigated the effect of alignment on this perception. The aim of this article is to determine whether people with amputation could perceive the alignment perturbations of their prostheses and effectively communicate them. A randomized controlled perturbation of angular (3 and 6 degrees) and translational (5 and 10 mm) alignments in the sagittal (flexion, extension, and anterior and posterior translations) and coronal (abduction, adduction, and medial and lateral translations) planes were induced from an aligned condition in 11 subjects with transtibial prostheses. The perception was evaluated when standing (static) and immediately after walking (dynamic) using software that used a visual analog scale under each alignment condition. In the coronal plane, Friedman test demonstrated general statistical differences in static (p < 0.001) and dynamic (p < 0.001) measures of perceptions with angular perturbations. In the sagittal plane, it also demonstrated general statistical differences in late-stance dynamic measures of perceptions (p < 0.001) with angular perturbations, as well as in early-stance dynamic measures of perceptions (p < 0.05) with translational perturbations. Fisher exact test suggested that people with amputation's perceptions were good indicators for coronal angle malalignments but less reliable when defining other alignment conditions.

Analytic properties for the honeycomb lattice Green function at the origin

NASA Astrophysics Data System (ADS)

Joyce, G. S.

2018-05-01

The analytic properties of the honeycomb lattice Green function are investigated, where is a complex variable which lies in a plane. This double integral defines a single-valued analytic function provided that a cut is made along the real axis from w  =  ‑3 to . In order to analyse the behaviour of along the edges of the cut it is convenient to define the limit function where . It is shown that and can be evaluated exactly for all in terms of various hypergeometric functions, where the argument function is always real-valued and rational. The second-order linear Fuchsian differential equation satisfied by is also used to derive series expansions for and which are valid in the neighbourhood of the regular singular points and . Integral representations are established for and , where with . In particular, it is proved that where J 0(z) and Y 0(z) denote Bessel functions of the first and second kind, respectively. The results derived in the paper are utilized to evaluate the associated logarithmic integral where w lies in the cut plane. A new set of orthogonal polynomials which are connected with the honeycomb lattice Green function are also briefly discussed. Finally, a link between and the theory of Pearson random walks in a plane is established.

A prospectus for Thematic Mapper research in the Earth sciences

NASA Technical Reports Server (NTRS)

1984-01-01

Earth science applications of Thematic Mapper (TM) imagery are discussed. Prospective research themes are defined in a general sense in relation to the technical measurement capabilities of the TM and the various types of Earth information that can potentially be derived from multispectral TM imagery. An overview of the system developed to acquire and reduce TM data is presented. The technical capabilities of this system are presented in detail. The orbital performance of the TM sensor is described, based upon the analysis of LANDSAT 4 and 5 TM data collected to date.

Actively mode-locked Tm-Ho:LiYF4 and Tm-Ho:BaY2F8 lasers

NASA Astrophysics Data System (ADS)

Gatti, D.; Galzerano, G.; Toncelli, A.; Tonelli, M.; Laporta, P.

2007-01-01

We report on the generation of mode-locking pulse trains with high average output powers from diode-pumped Tm-Ho:LiYF4 and Tm-Ho:BaY2F8 lasers emitting at around 2 μm. The highest output power of 365 mW was obtained with the Tm-Ho:YLF4 laser, whereas the shortest pulse duration of 120 ps and the widest tunability range of 59 nm was achieved with the Tm-Ho:BaY2F8 laser.

Research and Development of High Energy 2 - Micron Lasers Based on TM: Doped Ceramic Laser Gain Media and TM: Doped Optical Fibers

DTIC Science & Technology

2016-07-20

AFRL-AFOSR-VA-TR-2016-0257 RESEARCH AND DEVELOPMENT OF HIGH ENERGY 2 - MICRON LASERS BASED ON TM: DOPED CERAMIC LASER GAIN MEDIA AND TM: DOPED...2010 to 01/03/2016 4. TITLE AND SUBTITLE RESEARCH AND DEVELOPMENT OF HIGH ENERGY 2 - MICRON LASERS BASED ON TM: DOPED CERAMIC LASER GAIN MEDIA AND...NOTES 14. ABSTRACT Our research and development of 2-μm femtosecond lasers has included development of mode-locked Tm:fiber lasers , super-continuum

Temperature-dependence of isometric tension and cross-bridge kinetics of cardiac muscle fibers reconstituted with a tropomyosin internal deletion mutant.

PubMed

Lu, Xiaoying; Tobacman, Larry S; Kawai, Masataka

2006-12-01

The effect of temperature on isometric tension and cross-bridge kinetics was studied with a tropomyosin (Tm) internal deletion mutant AS-Delta23Tm (Ala-Ser-Tm Delta(47-123)) in bovine cardiac muscle fibers by using the thin filament extraction and reconstitution technique. The results are compared with those from actin reconstituted alone, cardiac muscle-derived control acetyl-Tm, and recombinant control AS-Tm. In all four reconstituted muscle groups, isometric tension and stiffness increased linearly with temperature in the range 5-40 degrees C for fibers activated in the presence of saturating ATP and Ca(2+). The slopes of the temperature-tension plots of the two controls were very similar, whereas the slope derived from fibers with actin alone had approximately 40% the control value, and the slope from mutant Tm had approximately 36% the control value. Sinusoidal analysis was performed to study the temperature dependence of cross-bridge kinetics. All three exponential processes A, B, and C were identified in the high temperature range (30-40 degrees C); only processes B and C were identified in the mid-temperature range (15-25 degrees C), and only process C was identified in the low temperature range (5-10 degrees C). At a given temperature, similar apparent rate constants (2pia, 2pib, 2pic) were observed in all four muscle groups, whereas their magnitudes were markedly less in the order of AS-Delta23Tm < Actin < AS-Tm approximately Acetyl-Tm groups. Our observations are consistent with the hypothesis that Tm enhances hydrophobic and stereospecific interactions (positive allosteric effect) between actin and myosin, but Delta23Tm decreases these interactions (negative allosteric effect). Our observations further indicate that tension/cross-bridge is increased by Tm, but is diminished by Delta23Tm. We conclude that Tm affects the conformation of actin so as to increase the area of hydrophobic interaction between actin and myosin molecules.

Unmatched speed perceptions between overground and treadmill manual wheelchair propulsion in long-term manual wheelchair users.

PubMed

Chénier, Félix; Champagne, Audrey; Desroches, Guillaume; Gagnon, Dany H

2018-03-01

Manual wheelchair (MWC) propulsion is increasingly assessed on a motorized treadmill (TM), which is often considered more ecologically valid than stationary rollers. However, no clear consensus on the similarities between overground (OG) and TM propulsion has yet been reached. Furthermore, no study has investigated the participants' perceptions of propelling a MWC on a TM compared to OG. The present study aims to assess the perception of speed when propelling on a TM vs OG, and to relate this perception to measured spatiotemporal variables, kinetics and work. In this repeated-measures study, the propulsion's spatiotemporal variables, kinetics, and work of nineteen experienced wheelchair users with a spinal cord injury were compared between three conditions: 1) OG at a self-selected speed, 2) on a TM at a self-selected speed perceived as being similar to the OG speed (TM perceived ), and 3) on a TM at the same speed as OG (TM matched ). Each variable was compared between conditions using an analysis of variance for repeated measures. All participants selected a lower speed for TM perceived than OG, with a difference of -0.6 m/s (-44%). This adaptation may be due to a combination of two factors: 1) the absence of speed information, and 2) the feeling of urgency to grab the wheels during the recovery phase. The power output, work per cycle, and work per minute were also much lower on TM perceived than OG. However, in contrast to other work on MWC propulsion on a TM, the kinetic variables assessed were all similar between the OG and TM matched conditions. Training on a TM should be performed at a speed that matches the OG speed and not at a self-selected speed on the TM, which would reduce the power output and work and therefore reduce the efficiency of the training. Copyright © 2018 Elsevier B.V. All rights reserved.

Conserved Asp-137 is important for both structure and regulatory functions of cardiac α-tropomyosin (α-TM) in a novel transgenic mouse model expressing α-TM-D137L.

PubMed

Yar, Sumeyye; Chowdhury, Shamim A K; Davis, Robert T; Kobayashi, Minae; Monasky, Michelle M; Rajan, Sudarsan; Wolska, Beata M; Gaponenko, Vadim; Kobayashi, Tomoyoshi; Wieczorek, David F; Solaro, R John

2013-06-07

α-Tropomyosin (α-TM) has a conserved, charged Asp-137 residue located in the hydrophobic core of its coiled-coil structure, which is unusual in that the residue is found at a position typically occupied by a hydrophobic residue. Asp-137 is thought to destabilize the coiled-coil and so impart structural flexibility to the molecule, which is believed to be crucial for its function in the heart. A previous in vitro study indicated that the conversion of Asp-137 to a more typical canonical Leu alters flexibility of TM and affects its in vitro regulatory functions. However, the physiological importance of the residue Asp-137 and altered TM flexibility is unknown. In this study, we further analyzed structural properties of the α-TM-D137L variant and addressed the physiological importance of TM flexibility in cardiac function in studies with a novel transgenic mouse model expressing α-TM-D137L in the heart. Our NMR spectroscopy data indicated that the presence of D137L introduced long range rearrangements in TM structure. Differential scanning calorimetry measurements demonstrated that α-TM-D137L has higher thermal stability compared with α-TM, which correlated with decreased flexibility. Hearts of transgenic mice expressing α-TM-D137L showed systolic and diastolic dysfunction with decreased myofilament Ca(2+) sensitivity and cardiomyocyte contractility without changes in intracellular Ca(2+) transients or post-translational modifications of major myofilament proteins. We conclude that conversion of the highly conserved Asp-137 to Leu results in loss of flexibility of TM that is important for its regulatory functions in mouse hearts. Thus, our results provide insight into the link between flexibility of TM and its function in ejecting hearts.

Conserved Asp-137 Is Important for both Structure and Regulatory Functions of Cardiac α-Tropomyosin (α-TM) in a Novel Transgenic Mouse Model Expressing α-TM-D137L*

PubMed Central

Yar, Sumeyye; Chowdhury, Shamim A. K.; Davis, Robert T.; Kobayashi, Minae; Monasky, Michelle M.; Rajan, Sudarsan; Wolska, Beata M.; Gaponenko, Vadim; Kobayashi, Tomoyoshi; Wieczorek, David F.; Solaro, R. John

2013-01-01

α-Tropomyosin (α-TM) has a conserved, charged Asp-137 residue located in the hydrophobic core of its coiled-coil structure, which is unusual in that the residue is found at a position typically occupied by a hydrophobic residue. Asp-137 is thought to destabilize the coiled-coil and so impart structural flexibility to the molecule, which is believed to be crucial for its function in the heart. A previous in vitro study indicated that the conversion of Asp-137 to a more typical canonical Leu alters flexibility of TM and affects its in vitro regulatory functions. However, the physiological importance of the residue Asp-137 and altered TM flexibility is unknown. In this study, we further analyzed structural properties of the α-TM-D137L variant and addressed the physiological importance of TM flexibility in cardiac function in studies with a novel transgenic mouse model expressing α-TM-D137L in the heart. Our NMR spectroscopy data indicated that the presence of D137L introduced long range rearrangements in TM structure. Differential scanning calorimetry measurements demonstrated that α-TM-D137L has higher thermal stability compared with α-TM, which correlated with decreased flexibility. Hearts of transgenic mice expressing α-TM-D137L showed systolic and diastolic dysfunction with decreased myofilament Ca2+ sensitivity and cardiomyocyte contractility without changes in intracellular Ca2+ transients or post-translational modifications of major myofilament proteins. We conclude that conversion of the highly conserved Asp-137 to Leu results in loss of flexibility of TM that is important for its regulatory functions in mouse hearts. Thus, our results provide insight into the link between flexibility of TM and its function in ejecting hearts. PMID:23609439

Cultivation of a human-associated TM7 phylotype reveals a reduced genome and epibiotic parasitic lifestyle.

PubMed

He, Xuesong; McLean, Jeffrey S; Edlund, Anna; Yooseph, Shibu; Hall, Adam P; Liu, Su-Yang; Dorrestein, Pieter C; Esquenazi, Eduardo; Hunter, Ryan C; Cheng, Genhong; Nelson, Karen E; Lux, Renate; Shi, Wenyuan

2015-01-06

The candidate phylum TM7 is globally distributed and often associated with human inflammatory mucosal diseases. Despite its prevalence, the TM7 phylum remains recalcitrant to cultivation, making it one of the most enigmatic phyla known. In this study, we cultivated a TM7 phylotype (TM7x) from the human oral cavity. This extremely small coccus (200-300 nm) has a distinctive lifestyle not previously observed in human-associated microbes. It is an obligate epibiont of an Actinomyces odontolyticus strain (XH001) yet also has a parasitic phase, thereby killing its host. This first completed genome (705 kb) for a human-associated TM7 phylotype revealed a complete lack of amino acid biosynthetic capacity. Comparative genomics analyses with uncultivated environmental TM7 assemblies show remarkable conserved gene synteny and only minimal gene loss/gain that may have occurred as TM7x adapted to conditions within the human host. Transcriptomic and metabolomic profiles provided the first indications, to our knowledge, that there is signaling interaction between TM7x and XH001. Furthermore, the induction of TNF-α production in macrophages by XH001 was repressed in the presence of TM7x, suggesting its potential immune suppression ability. Overall, our data provide intriguing insights into the uncultivability, pathogenicity, and unique lifestyle of this previously uncharacterized oral TM7 phylotype.

Cultivation of a human-associated TM7 phylotype reveals a reduced genome and epibiotic parasitic lifestyle

PubMed Central

He, Xuesong; McLean, Jeffrey S.; Edlund, Anna; Yooseph, Shibu; Hall, Adam P.; Liu, Su-Yang; Dorrestein, Pieter C.; Esquenazi, Eduardo; Hunter, Ryan C.; Cheng, Genhong; Nelson, Karen E.; Lux, Renate; Shi, Wenyuan

2015-01-01

The candidate phylum TM7 is globally distributed and often associated with human inflammatory mucosal diseases. Despite its prevalence, the TM7 phylum remains recalcitrant to cultivation, making it one of the most enigmatic phyla known. In this study, we cultivated a TM7 phylotype (TM7x) from the human oral cavity. This extremely small coccus (200–300 nm) has a distinctive lifestyle not previously observed in human-associated microbes. It is an obligate epibiont of an Actinomyces odontolyticus strain (XH001) yet also has a parasitic phase, thereby killing its host. This first completed genome (705 kb) for a human-associated TM7 phylotype revealed a complete lack of amino acid biosynthetic capacity. Comparative genomics analyses with uncultivated environmental TM7 assemblies show remarkable conserved gene synteny and only minimal gene loss/gain that may have occurred as TM7x adapted to conditions within the human host. Transcriptomic and metabolomic profiles provided the first indications, to our knowledge, that there is signaling interaction between TM7x and XH001. Furthermore, the induction of TNF-α production in macrophages by XH001 was repressed in the presence of TM7x, suggesting its potential immune suppression ability. Overall, our data provide intriguing insights into the uncultivability, pathogenicity, and unique lifestyle of this previously uncharacterized oral TM7 phylotype. PMID:25535390

Thrombomodulin reduces tumorigenic and metastatic potential of lung cancer cells by up-regulation of E-cadherin and down-regulation of N-cadherin expression.

PubMed

Zheng, Nana; Huo, Zihe; Zhang, Bin; Meng, Mei; Cao, Zhifei; Wang, Zhiwei; Zhou, Quansheng

2016-08-05

Thrombomodulin (TM) is an endothelial cell membrane protein and plays critical roles in anti-thrombosis, anti-inflammation, vascular endothelial protection, and is traditionally regarded as a "vascular protection god". In recent years, although TM has been reported to be down-regulated in a variety of malignant tumors including lung cancer, the role and mechanism of TM in lung cancer are enigmatic. In this study, we found that induction of TM overexpression by cholesterol-reducing drug atorvastatin significantly diminished the tumorigenic capability of the lung cancer cells. Moreover, we demonstrated that TM overexpression caused G0/G1 phase arrest and markedly reduced the colony forming capability of the cells. Furthermore, overexpression of TM inhibited cell migration and invasion. Consistently, depletion of TM promoted cell growth, reduced the cell population at the G0/G1 phase, and enhanced cell migratory ability. Mechanistic study revealed that TM up-regulated E-cadherin but down-regulated N-cadherin expression, resulting in reversal of epithelial-mesenchymal transition (EMT) in the lung cancer cells. Moreover, silencing TM expression led to decreased E-cadherin and increased N-cadherin. Taken together, our study suggests that TM functions as a tumor suppressive protein, providing a conceptual framework for inducing TM overexpression as a sensible strategy and approach for novel anti-lung cancer drug discovery. Copyright © 2016 Elsevier Inc. All rights reserved.

Tropomyosin inhibits ADF/cofilin-dependent actin filament dynamics.

PubMed

Ono, Shoichiro; Ono, Kanako

2002-03-18

Tropomyosin binds to actin filaments and is implicated in stabilization of actin cytoskeleton. We examined biochemical and cell biological properties of Caenorhabditis elegans tropomyosin (CeTM) and obtained evidence that CeTM is antagonistic to ADF/cofilin-dependent actin filament dynamics. We purified CeTM, actin, and UNC-60B (a muscle-specific ADF/cofilin isoform), all of which are derived from C. elegans, and showed that CeTM and UNC-60B bound to F-actin in a mutually exclusive manner. CeTM inhibited UNC-60B-induced actin depolymerization and enhancement of actin polymerization. Within isolated native thin filaments, actin and CeTM were detected as major components, whereas UNC-60B was present at a trace amount. Purified UNC-60B was unable to interact with the native thin filaments unless CeTM and other associated proteins were removed by high-salt extraction. Purified CeTM was sufficient to restore the resistance of the salt-extracted filaments from UNC-60B. In muscle cells, CeTM and UNC-60B were localized in different patterns. Suppression of CeTM by RNA interference resulted in disorganized actin filaments and paralyzed worms in wild-type background. However, in an ADF/cofilin mutant background, suppression of CeTM did not worsen actin organization and worm motility. These results suggest that tropomyosin is a physiological inhibitor of ADF/cofilin-dependent actin dynamics.

Exact Results for the Nonergodicity of d -Dimensional Generalized Lévy Walks

NASA Astrophysics Data System (ADS)

Albers, Tony; Radons, Günter

2018-03-01

We provide analytical results for the ensemble-averaged and time-averaged squared displacement, and the randomness of the latter, in the full two-dimensional parameter space of the d -dimensional generalized Lévy walk introduced by Shlesinger et al. [Phys. Rev. Lett. 58, 1100 (1987), 10.1103/PhysRevLett.58.1100]. In certain regions of the parameter plane, we obtain surprising results such as the divergence of the mean-squared displacements, the divergence of the ergodicity breaking parameter despite a finite mean-squared displacement, and subdiffusion which appears superdiffusive when one only considers time averages.

Quantum phases of dimerized and frustrated Heisenberg spin chains with s = 1/2, 1 and 3/2: an entanglement entropy and fidelity study.

PubMed

Goli, V M L Durga Prasad; Sahoo, Shaon; Ramasesha, S; Sen, Diptiman

2013-03-27

We study here different regions in phase diagrams of the spin-1/2, spin-1 and spin-3/2 one-dimensional antiferromagnetic Heisenberg systems with frustration (next-nearest-neighbor interaction J2) and dimerization (δ). In particular, we analyze the behaviors of the bipartite entanglement entropy and fidelity at the gapless to gapped phase transitions and across the lines separating different phases in the J2-δ plane. All the calculations in this work are based on numerical exact diagonalizations of finite systems.

Particle paths and phase plane for time-dependent similarity solutions of the one-dimensional Vlasov-Maxwell equations

NASA Technical Reports Server (NTRS)

Roberts, Dana Aaron; Abraham-Shrauner, Barbara

1987-01-01

The phase trajectories of particles in a plasma described by the one-dimensional Vlasov-Maxwell equations are determined qualitatively, analyzing exact general similarity solutions for the cases of temporally damped and growing (sinusoidal or localized) electric fields. The results of numerical integration in both untransformed and Lie-group point-transformed coordinates are presented in extensive graphs and characterized in detail. The implications of the present analysis for the stability of BGK equilibria are explored, and the existence of nonlinear solutions arbitrarily close to and significantly different from the BGK solutions is demonstrated.

Propagation of thickness-twist waves in a piezoelectric ceramic plate with unattached electrodes.

PubMed

Qian, Zheng-Hua; Kishimoto, Kikuo; Yang, Jiashi

2009-06-01

We analyze the propagation of thickness-twist waves in an unbounded piezoelectric ceramic plate with air gaps between the plate surfaces and two electrodes. These waves are also called anti-plane or shear-horizontal waves with one displacement component only. An exact solution is obtained from the equations of the linear theory of piezoelectricity. Dispersion relations of the waves are obtained and plotted. Results show that the wave frequency or speed is sensitive to the air gap thickness. This effect can be used to manipulate the behavior of the waves and has implications in acoustic wave devices.

Nonlinear phenomena in general relativity

NASA Astrophysics Data System (ADS)

Allahyari, Alireza; Firouzjaee, Javad T.; Mansouri, Reza

2018-04-01

The perturbation theory plays an important role in studying structure formation in cosmology and post-Newtonian physics, but not all phenomena can be described by the linear perturbation theory. Thus, it is necessary to study exact solutions or higher-order perturbations. Specifically, we study black hole (apparent) horizons and the cosmological event horizon formation in the perturbation theory. We emphasize that in the perturbative regime of the gravitational potential these horizons cannot form in the lower order. Studying the infinite plane metric, we show that, to capture the cosmological constant effect, we need at least a second-order expansion.

Proximity-induced superconductivity in Landau-quantized graphene monolayers

NASA Astrophysics Data System (ADS)

Cohnitz, Laura; De Martino, Alessandro; Häusler, Wolfgang; Egger, Reinhold

2017-10-01

We consider massless Dirac fermions in a graphene monolayer in the ballistic limit, subject to both a perpendicular magnetic field B and a proximity-induced pairing gap Δ . When the chemical potential is at the Dirac point, our exact solution of the Bogoliubov-de Gennes equation yields Δ -independent relativistic Landau levels. Since eigenstates depend on Δ , many observables nevertheless are sensitive to pairing, e.g., the local density of states or the edge state spectrum. By solving the problem with an additional in-plane electric field, we also discuss how snake states are influenced by a pairing gap.

The Dynamics and Evolution of Poles and Rogue Waves for Nonlinear Schrödinger Equations*

NASA Astrophysics Data System (ADS)

Chiu, Tin Lok; Liu, Tian Yang; Chan, Hiu Ning; Wing Chow, Kwok

2017-09-01

Rogue waves are unexpectedly large deviations from equilibrium or otherwise calm positions in physical systems, e.g. hydrodynamic waves and optical beam intensities. The profiles and points of maximum displacements of these rogue waves are correlated with the movement of poles of the exact solutions extended to the complex plane through analytic continuation. Such links are shown to be surprisingly precise for the first order rogue wave of the nonlinear Schrödinger (NLS) and the derivative NLS equations. A computational study on the second order rogue waves of the NLS equation also displays remarkable agreements.

Differentiation of tumor from viable myocardium using cardiac tagging with MR imaging.

PubMed

Bouton, S; Yang, A; McCrindle, B W; Kidd, L; McVeigh, E R; Zerhouni, E A

1991-01-01

We report the application of myocardial tagging by MR to define tissue planes and differentiate contractile from noncontractile tissue in a neonate with congenital cardiac rhabdomyoma. Using custom-written pulse programming software, six 2 mm thick radiofrequency (RF) slice-selective presaturation pulses (tags) were used to label the chest wall and myocardium in a star pattern in diastole, approximately 60 ms before the R-wave gating trigger. This method successfully delineated the myocardium from noncontractile tumor, providing information that influenced clinical management. This RF tagging technique allowed us to confirm the exact intramyocardial location of a congenital cardiac tumor.

Stress intensity factors in a hollow cylinder containing a radial crack

NASA Technical Reports Server (NTRS)

Delale, F.

1980-01-01

An exact formulation of the plane elasticity problem for a hollow cylinder or a disk containing a radial crack is given. The crack may be an external edge crack, an internal edge crack, or an embedded crack. It is assumed that on the crack surfaces the shear traction is zero and the normal traction is an arbitrary function of r. For various crack geometries and radius ratios, the numerical results are obtained for a uniform crack surface pressure, for a uniform pressure acting on the inside wall of the cylinder, and for a rotating disk.

Stress intensity factors in a hollow cylinder containing a radial crack

NASA Technical Reports Server (NTRS)

Delale, F.; Erdogan, F.

1982-01-01

In this paper, an exact formulation of the plane elasticity problem for a hollow cylinder or a disk containing a radial crack is given. The crack may be an external edge crack, an internal edge crack, or an embedded crack. It is assumed that on the crack surfaces the shear traction is zero, and the normal traction is an arbitrary function of radius. For various crack geometries and radius ratios, the numerical results are obtained for a uniform crack surface pressure, for a uniform pressure acting on the inside wall of the cylinder, and for a rotating disk.

The role of charged particles in the positive corona-generated photon count in a rod to plane air gap

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bian, X. M.; Wang, Y. J.; MacAlpine, J. M. K.

The relationship between the calculated charged-particle densities in positive corona, the rate of streamer production, and the photon count from the corona were investigated and found to be closely related. Both the densities of electrons and positive ions peaked at 11.8 kV, near the corona inception voltage; they then fell rapidly before slowly rising again. This behavior was exactly matched by the measured photon count. The calculation of the charged-particle density in a positive corona was achieved by means of a fluid model.

Individual complex Dirac eigenvalue distributions from random matrix theory and comparison to quenched lattice QCD with a quark chemical potential.

PubMed

Akemann, G; Bloch, J; Shifrin, L; Wettig, T

2008-01-25

We analyze how individual eigenvalues of the QCD Dirac operator at nonzero quark chemical potential are distributed in the complex plane. Exact and approximate analytical results for both quenched and unquenched distributions are derived from non-Hermitian random matrix theory. When comparing these to quenched lattice QCD spectra close to the origin, excellent agreement is found for zero and nonzero topology at several values of the quark chemical potential. Our analytical results are also applicable to other physical systems in the same symmetry class.

Self-repeating properties of four-petal Gaussian vortex beams in quadratic index medium

NASA Astrophysics Data System (ADS)

Zou, Defeng; Li, Xiaohui; Chai, Tong; Zheng, Hairong

2018-05-01

In this paper, we investigate the propagation properties of four-petal Gaussian vortex (FPGV) beams propagating through the quadratic index medium, obtaining the analytical expression of FPGV beams. The effects of beam order n, topological charge m and beam waist ω0 are investigated. Results show that quadratic index medium support periodic distributions of FPGV beams. A hollow optical wall or an optical central principal maximum surrounded by symmetrical sidelobes will occur at the center of a period. At length, they will evolve into four petals structure, exactly same as the intensity distributions at source plane.

Lectures on the scattering of light. [by dielectric sphere

NASA Technical Reports Server (NTRS)

Saxon, D. S.

1974-01-01

The exact (Mie) theory for the scattering of a plane wave by a dielectric sphere is presented. Since this infinite series solution is computationally impractical for large spheres, another formulation is given in terms of an integral equation valid for a bounded, but otherwise general array of scatterers. This equation is applied to the scattering by a single sphere, and several methods are suggested for approximating the scattering cross section in closed form. A tensor scattering matrix is introduced, in terms of which some general scattering theorems are derived. The application of the formalism to multiple scattering is briefly considered.

Atomic ordering in GaAsP

NASA Astrophysics Data System (ADS)

Chen, G. S.; Jaw, D. H.; Stringfellow, G. B.

1991-04-01

CuPt type ordering, which consists of a monolayer compositional modulation along one of the 4 <111> directions in the lattice, was studied using transmission electron microscopy for GaAs1-xPx with values of x extending from 0.25 to 0.85. The samples were grown by organometallic vapor phase epitaxy on nominal (001) GaAs substrates that were misoriented by varying amounts in three directions. No CuPt type ordering was observed for GaAs1-xPx with x ≤0.35, while ordering was found to occur for 0.4≤x≤0.85. The direction of substrate misorientation has a major effect on the determination of which of the four possible CuPt variants are formed for 0.4≤x≤0.85. Two variants, with ordering on the (1¯11) and (11¯1) planes, appear for epilayers grown on substrates oriented exactly on the (001) plane and for substrates misoriented by 6° towards the [110] direction. Only one variant, with ordering on the (1¯11) plane, appears for epilayers grown on substrates misoriented by 6° towards [1¯10]. These ordering-induced spots observed in transmission electron diffraction (TED) patterns for GaAsP occur only for the [110] cross section. From TED studies of GaInP grown on similar substrates, we conclude that the CuPt variants in GaAsP are exactly the same as for GaInP. Further evidence supporting this conclusion was obtained by growing first a layer of GaInP followed by a layer of GaAsP. High-resolution dark field electron micrographs show domains of the same variants in both layers. A mechanism describing the formation of the specific ordered variant for both GaAsP and GaInP is proposed. From studies of ordering in a strain-layer superlattice, the strain due to lattice mismatch was found to play no significant role in the propagation of ordered domains. Microtwins, also generated due to lattice mismatch, can act as domain boundaries and prevent the propagation of the ordered domains.

Luminescent properties of Tm3-xLuxAl5O12:Ce single crystalline films

NASA Astrophysics Data System (ADS)

Zorenko, Yu.; Gorbenko, V.; Zorenko, T.; Suchocki, A.; Zhydachevskyy, Ya.; Fabisiak, K.; Paprocki, K.; Bilski, P.; Twardak, A.; Fedorov, A.

2017-07-01

The work devoted to the investigation of a new luminescent and scintillation material based on the single crystalline films (SCFs) of Tm3-xLuxAG:Ce garnet; x = 0-1.5, grown by LPE method from PbO based flux. The best scintillation properties are achieved for SCFs of Tm1.5Lu1.5Al5O12:Ce composition. We have found that direct Tm → Ce and backside Ce → Tm energy transfer processes are observed in Tm1.5Lu1.5Al5O12:Ce. Due to elimination of traps in the 300-450 °C range, the relatively fast scintillation decay is realized in highly doped Tm1.5Lu1.5Al5O12:Ce SCFs. For this reason, Tm doping can be considered as a suitable way for improvement of the scintillation efficiency in other Ce3+ doped garnet compounds.

Latent progenitor cells as potential regulators for tympanic membrane regeneration

NASA Astrophysics Data System (ADS)

Kim, Seung Won; Kim, Jangho; Seonwoo, Hoon; Jang, Kyung-Jin; Kim, Yeon Ju; Lim, Hye Jin; Lim, Ki-Taek; Tian, Chunjie; Chung, Jong Hoon; Choung, Yun-Hoon

2015-06-01

Tympanic membrane (TM) perforation, in particular chronic otitis media, is one of the most common clinical problems in the world and can present with sensorineural healing loss. Here, we explored an approach for TM regeneration where the latent progenitor or stem cells within TM epithelial layers may play an important regulatory role. We showed that potential TM stem cells present highly positive staining for epithelial stem cell markers in all areas of normal TM tissue. Additionally, they are present at high levels in perforated TMs, especially in proximity to the holes, regardless of acute or chronic status, suggesting that TM stem cells may be a potential factor for TM regeneration. Our study suggests that latent TM stem cells could be potential regulators of regeneration, which provides a new insight into this clinically important process and a potential target for new therapies for chronic otitis media and other eardrum injuries.

Motion of the Tympanic Membrane after Cartilage Tympanoplasty Determined by Stroboscopic Holography

PubMed Central

Aarnisalo, Antti A.; Cheng, Jeffrey T.; Ravicz, Michael E.; Furlong, Cosme; Merchant, Saumil N.; Rosowski, John J.

2009-01-01

Stroboscopic holography was used to quantify dynamic deformations of the tympanic membrane (TM) of the entire surface of the TM before and after cartilage tympanoplasty of the posterior or posterior-superior part of the TM. Cartilage is widely used in tympanoplasties to provide mechanical stability for the TM. Three human cadaveric temporal bones were used. A 6 mm × 3 mm oval cartilage graft was placed through the widely opened facial recess onto the medial surface of the posterior or posterior-superior part of the TM. The graft was either in contact with the bony tympanic rim and manubrium or not. Graft thickness was either 0.5 or 1.0 mm. Stroboscopic holography produced displacement amplitude and phase maps of the TM surface in response to stimulus sound. Sound stimuli were 0.5, 1, 4 and 7 (or 8) kHz tones. Middle ear impedance was measured from the motion of the entire TM. Cartilage placement generally produced reductions in the motion of the TM apposed to the cartilage, especially at 4 kHz and 7 or 8 kHz. Some parts of the TM showed altered motion compared to the control in all three cases. In general, middle ear impedance was either unchanged or increased somewhat after cartilage reconstruction both at low (0.5 and 1 kHz) and high (4 and 7 kHz) frequencies. At 4 kHz, with the 1.0 mm thick graft that was in contact with the bony tympanic rim, the impedance slightly decreased. While our earlier work with time-averaged holography allowed us to observe differences in the pattern of TM motion caused by application of cartilage to the TM, stroboscopic holography is more sensitive to TM motions and allowed us to quantify the magnitude and phase of motion of each point on the TM surface. Nonetheless, our results are similar to those of our earlier work: The placement of cartilage on the medial surface of TM reduces the motion of the TM that apposes the cartilage. These obvious local changes occur even though the cartilage had little effect on the sound-induced motion of the stapes. PMID:19909803

Electrodynamic eigenmodes in cellular morphology.

PubMed

Cifra, M

2012-09-01

Eigenmodes of the spherical and ellipsoidal dielectric electromagnetic resonator have been analysed. The sizes and shape of the resonators have been chosen to represent the shape of the interphase and dividing animal cell. Electromagnetic modes that have shape exactly suitable for positioning of the sufficiently large organelles in cell (centrosome, nucleus) have been identified. We analysed direction and magnitude of dielectrophoretic force exerted on large organelles by electric field of the modes. We found that the TM(1m1) mode in spherical resonator acts by centripetal force which drags the large organelles which have higher permittivity than the cytosol to the center of the cell. TM-kind of mode in the ellipsoidal resonator acts by force on large polarizable organelles in a direction that corresponds to the movement of the centrosomes (also nucleus) observed during the cell division, i.e. to the foci of the ellipsoidal cell. Minimal required force (10(-16) N), gradient of squared electric field and corresponding energy (10(-16) J) of the mode have been calculated to have biological significance within the periods on the order of time required for cell division. Minimal required energy of the mode, in order to have biological significance, can be lower in the case of resonance of organelle with the field of the cellular resonator mode. In case of sufficient energy in the biologically relevant mode, electromagnetic field of the mode will act as a positioning or steering mechanism for centrosome and nucleus in the cell, thus contribute to the spatial and dynamical self-organization in biological systems. Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

Tryptophan Scanning Reveals Dense Packing of Connexin Transmembrane Domains in Gap Junction Channels Composed of Connexin32.

PubMed

Brennan, Matthew J; Karcz, Jennifer; Vaughn, Nicholas R; Woolwine-Cunningham, Yvonne; DePriest, Adam D; Escalona, Yerko; Perez-Acle, Tomas; Skerrett, I Martha

2015-07-10

Tryptophan was substituted for residues in all four transmembrane domains of connexin32. Function was assayed using dual cell two-electrode voltage clamp after expression in Xenopus oocytes. Tryptophan substitution was poorly tolerated in all domains, with the greatest impact in TM1 and TM4. For instance, in TM1, 15 substitutions were made, six abolished coupling and five others significantly reduced function. Only TM2 and TM3 included a distinct helical face that lacked sensitivity to tryptophan substitution. Results were visualized on a comparative model of Cx32 hemichannel. In this model, a region midway through the membrane appears highly sensitive to tryptophan substitution and includes residues Arg-32, Ile-33, Met-34, and Val-35. In the modeled channel, pore-facing regions of TM1 and TM2 were highly sensitive to tryptophan substitution, whereas the lipid-facing regions of TM3 and TM4 were variably tolerant. Residues facing a putative intracellular water pocket (the IC pocket) were also highly sensitive to tryptophan substitution. Although future studies will be required to separate trafficking-defective mutants from those that alter channel function, a subset of interactions important for voltage gating was identified. Interactions important for voltage gating occurred mainly in the mid-region of the channel and focused on TM1. To determine whether results could be extrapolated to other connexins, TM1 of Cx43 was scanned revealing similar but not identical sensitivity to TM1 of Cx32. © 2015 by The American Society for Biochemistry and Molecular Biology, Inc.

Tracheomalacia is associated with lower FEV1 and Pseudomonas acquisition in children with CF

PubMed Central

Fischer, Anthony J.; Singh, Sachinkumar B.; Adam, Ryan J.; Stoltz, David A.; Baranano, Christopher F.; Kao, Simon; Weinberger, Miles M.; McCray, Paul B.; Starner, Timothy D.

2016-01-01

BACKGROUND Tracheomalacia (TM) occurs in approximately 1 in 2,100 children. Because the trachea develops abnormally in animal models of cystic fibrosis (CF), we hypothesized this may also occur in children with CF, increasing their risk of TM. PURPOSE To examine the prevalence and clinical consequences of TM in children with CF. METHODS We studied children with CF born between 1995 and 2012. TM was defined as dynamic collapse of the trachea, and the severity was recorded as described in the chart. The effect of TM on patient outcomes, including FEV1, CT changes, and acquisition of CF pathogens, was assessed using a longitudinal patient dataset. RESULTS 89% of children with CF had at least one bronchoscopy (n = 97/109). 15% of these children had TM described in any bronchoscopy report (n= 15/97). Of the patients with TM, 8 had meconium ileus (p = 0.003) and all were pancreatic insufficient. Pseudomonas aeruginosa infection occurred 1.3 years earlier among children with TM (p = 0.01). Starting FEV1 values by age 8 were diminished by over 18% of predicted for patients with TM. Life-threatening episodes of airway obstruction occurred in 3 of 15 patients with CF and TM, including one leading to death. Gender, prematurity, and hepatic disease were not associated with TM. No difference was observed in the frequency of bronchiectasis. CONCLUSIONS TM is significantly more common in infants and children with CF than in the general population and is associated with airway obstruction and earlier Pseudomonas acquisition. PMID:24166775

A review of translational medicine. The future paradigm: how can we connect the orthopedic dots better?

PubMed

Mediouni, Mohamed; R Schlatterer, Daniel; Madry, Henning; Cucchiarini, Magali; Rai, Balwant

2017-11-01

Patients with complex medical and surgical problems often travel great distances to prestigious university medical centers in search of solutions and in some cases for nothing more than a diagnosis of their condition. Translational medicine (TM) is an emerging method and process of facilitating medical advances efficiently from the scientist to the clinician. Most established clinicians and those in training know very little about this new discipline. The purpose of this article is to illustrate TM in varied scientific, medical and surgical fields. Anecdotal events in medicine and orthopaedics based upon a practicing orthopaedic surgeon's training and clinical experience are presented. TM is rapidly assuming a greater presence in the medical community. The National Institute of Health (NIH) recognizes this discipline and has funded TM projects. Numerous institutions in Europe and the USA offer advanced degrees in TM. Finally there is a European Society for Translational Medicine (EUTMS), an International Society for Translational Medicine, and an Academy of Translational Medical Professionals (ATMP). The examples of TM presented in this article support the argument for the formation of more TM networks on the local and regional levels. The need for increased participation of researchers and clinicians requires further study to identify the economic and social impact of TM. The examples of TM presented in this article support the argument for the formation of more TM networks on the local and regional levels. Financial constraints for TM can be overcome by pooling government, academic, private, and industry resources in an organized fashion with oversight by a lead TM researcher.

Cross-Section Measurement of the 169Tm(n,3n)167Tm Reaction and Constraining the Branching Ratio of 167Tm

NASA Astrophysics Data System (ADS)

Champine, Brian; Gooden, Matthew; Thomas, Keenan; Krishichayan, F.; Norman, Eric; Scielzo, Nick; Tonchev, Anton; Tornow, Werner

2015-10-01

The cross section of the 169Tm(n,3n)167Tm reaction has been measured from 17.5 to 21.5 MeV using activation technique. This energy region was chosen to resolve the two different trends of the previous (n,3n) cross section measurements on 169Tm. In addition, the branching ratio of the 207.8 keV γ-ray line stemming from electron capture of 167Tm was measured to be 0.419(16). The result of these measurements provide more accurate diagnostic estimation of the so called reaction-in-flight neutrons produced via the internal confinement fusion plasma in deuterium-tritium capsules at the National Ignition Facility.

Functional reconstitution of the human serotonin receptor 5-HT(6) using synthetic transmembrane peptides.

PubMed

Lee, Won-Kyu; Han, Jason J; Jin, Bong-Suk; Boo, Doo Wan; Yu, Yeon Gyu

2009-12-18

Seven transmembrane (7TM) synthetic peptides mimicking the alpha-helical TM domains of the human serotonin receptor subtype-6 (5-HT(6)) were autonomously reconstituted in detergent micelle and liposome environments. The degree of assembly of the 7TM peptides was characterized by monitoring the fluorescence resonance energy transfer (FRET) between donor and acceptor probes labeled at the amino termini of the second and fourth TM-peptides, respectively. The FRET efficiency of these peptides significantly increased when the 7TM peptides were reconstituted in liposome compare to detergent micelles. Furthermore, the 7TM peptides reconstituted in liposomes selectively bound to free serotonin and serotonin-conjugated magnetic beads, yielding a dissociation constant of 0.84 microM. These results show that the seven individual TM domains of 5-HT(6) can spontaneously assemble into liposomes in a conformation that mimics a native structure, and further demonstrate that specific interactions between TM helices play a critical role in the folding and stabilizing of GPCRs. The autonomous assembly of 7TM-peptides can be applied to the screening of agonists for GPCRs that are difficult to manipulate.

Preliminary Study of Information Extraction of LANDSAT TM Data for a Suburban/regional Test Site

NASA Technical Reports Server (NTRS)

Toll, D. L.

1985-01-01

A substantial amount of spectral information is available from TM (as compared to MSS) data for a 14.25 square km area between Beltsville and Laurel, Maryland. Large buildings and street patterns were resolved in the TM imagery. While there was added information content in TM data for discriminating surburban/regional land cover, characteristics of MSS can improve land cover discrimination over TM when conventional classification procedures are used on digital data. The improved qualitization of TM is likely valuable in situations where there are spectral similarities between classes. The spatial resolution in TM decreased land cover discrimination as a result of increased within class variability. For many general digital evaluations, inclusion of four bands representing the four spectral regions can provide much useful land cover discrimination. Inclusion of TM 6 indicates an improvement in spectral class discrimination. Of primary spectral importance is the discrimination between water, vegetative surfaces, and impervious surfaces due to differences in thermal properties. Results from the principle component transformed data clearly indicates additional information content in TM over MSS.

Molecular cloing and bioinformatics analysis of lactate dehydrogenase from Taenia multiceps.

PubMed

Guo, Cheng; Wang, Yu; Huang, Xing; Wang, Ning; Yan, Ming; He, Ran; Gu, Xiaobin; Xie, Yue; Lai, Weimin; Jing, Bo; Peng, Xuerong; Yang, Guangyou

2017-10-01

Coenurus cerebralis, the larval stage (metacestode or coenurus) of Taenia multiceps, parasitizes sheep, goats, and other ruminants and causes coenurosis. In this study, we isolated and characterized complementary DNAs that encode lactate dehydrogenase A (Tm-LDHA) and B (Tm-LDHB) from the transcriptome of T. multiceps and expressed recombinant Tm-LDHB (rTm-LDHB) in Escherichia coli. Bioinformatic analysis showed that both Tm-LDH genes (LDHA and LDHB) contain a 996-bp open reading frame and encode a protein of 331 amino acids. After determination of the immunogenicity of the recombinant Tm-LDHB, an indirect enzyme-linked immunosorbent assay (ELISA) was developed for preliminary evaluation of the serodiagnostic potential of rTm-LDHB in goats. However, the rTm-LDHB-based indirect ELISA developed here exhibited specificity of only 71.42% (10/14) and sensitivity of 1:3200 in detection of goats infected with T. multiceps in the field. This study is the first to describe LDHA and LDHB of T. multiceps; meanwhile, our results indicate that rTm-LDHB is not a specific antigen candidate for immunodiagnosis of T. multiceps infection in goats.

Bumps of the wave structure function in non-Kolmogorov turbulence

NASA Astrophysics Data System (ADS)

Qiao, Chunhong; Lu, Lu; Zhang, Pengfei; Wang, Haitao; Huang, Honghua; Fan, Chengyu

2015-10-01

The analytical expressions for wave structure function of plane and spherical waves are derived both in the viscous dissipation and inertial range. Due to previously research, there is a discrepancy between theoretical results and the experimental datum in viscous dissipation range. In this paper, only considering the inertial range, taking plane waves for example, we give a comparison of results of WSF calculated by the analytical formula obtained in this paper and the numerical calculations of the definition at the fixed parameter (i.e., the generalized exponent α), it can be seen that the two results are in agreement with each other exactly. Based on non-Kolmogorov power spectrum, new characteristics for wave structure function (WSF) have been found for plane and spherical wave models when the different ratio of inner scale l0 and outer scale of turbulence L0 is obtained. In outer scale assumed finite case (i.e., L0 =1m), WSF obtains the maximum when α approximates to 3.3 both for plane and spherical wave models. In outer scale assumed infinite case (i.e., L0 = ∞), the WSF can be sorted into three parts, including two rapid-rising regions (i.e., 3.0 < α < 3.3 and 3.8 < α < 4.0 ) and one gently rising region (i.e., 3.3 < α < 3.8 ).Further, the changes of scaled WSF versus the ratio of separation distance and inner scale ( p/ l0 ) are investigated under mentioned above conditions for two models. In L0 = 1m case, both for plane and spherical waves, the value of α determines the bump position of WSF. In L0 = ∞ case, the bump of scaled WSF disappears when the generalized exponent has large values. The changings of scaled WSF monotonically increase as α increased when the generalized exponent is larger than11/3 for two models. Besides, the properties of spherical waves are similar to plane waves, except which the values of WSF and the scaled WSF are smaller than plane ones.

The role of charge transfer in the oxidation state change of Ce atoms in the TM13-CeO2(111) systems (TM = Pd, Ag, Pt, Au): a DFT + U investigation.

PubMed

Tereshchuk, Polina; Freire, Rafael L H; Ungureanu, Crina G; Seminovski, Yohanna; Kiejna, Adam; Da Silva, Juarez L F

2015-05-28

Despite extensive studies of transition metal (TM) clusters supported on ceria (CeO2), fundamental issues such as the role of the TM atoms in the change in the oxidation state of Ce atoms are still not well understood. In this work, we report a theoretical investigation based on static and ab initio molecular dynamics density functional theory calculations of the interaction of 13-atom TM clusters (TM = Pd, Ag, Pt, Au) with the unreduced CeO2(111) surface represented by a large surface unit cell and employing Hubbard corrections for the strong on-site Coulomb correlation in the Ce f-electrons. We found that the TM13 clusters form pyramidal-like structures on CeO2(111) in the lowest energy configurations with the following stacking sequence, TM/TM4/TM8/CeO2(111), while TM13 adopts two-dimensional structures at high energy structures. TM13 induces a change in the oxidation state of few Ce atoms (3 of 16) located in the topmost Ce layer from Ce(IV) (itinerant Ce f-states) to Ce(III) (localized Ce f-states). There is a charge flow from the TM atoms to the CeO2(111) surface, which can be explained by the electronegativity difference between the TM (Pd, Ag, Pt, Au) and O atoms, however, the charge is not uniformly distributed on the topmost O layer due to the pressure induced by the TM13 clusters on the underlying O ions, which yields a decrease in the ionic charge of the O ions located below the cluster and an increase in the remaining O ions. Due to the charge flow mainly from the TM8-layer to the topmost O-layer, the charge cannot flow from the Ce(IV) atoms to the O atoms with the same magnitude as in the clean CeO2(111) surface. Consequently, the effective cationic charge decreases mainly for the Ce atoms that have a bond with the O atoms not located below the cluster, and hence, those Ce atoms change their oxidation state from IV to III. This increases the size of the Ce(III) compared with the Ce(IV) cations, which builds-in a strain within the topmost Ce layer, and hence, also affecting the location of the Ce(III) cations and the structure of the TM13 clusters.

Blue upconversion with excitation into Tm ions at 780 nm in Yb- and Tm-codoped fluoride crystals

NASA Astrophysics Data System (ADS)

Zhang, X. X.; Hong, P.; Bass, M.; Chai, B. H. T.

1995-04-01

Strong blue emissions have been observed in fluoride crystals, such as LiYF4, BaY2F8, and KYF4, codoped with Tm3+ and Yb3+ when excited into the Tm3+ 3F4 state at ~780 nm. Energy transfer from Tm3+ to Yb3+ ions followed by the transfer from Yb3+ to Tm3+ was demonstrated to be responsible for the upconversion process. A pumping scheme is proposed based on this upconversion mechanism for blue-laser applications using these materials.

Spin-pumping and spin-Hall magnetoresistance (SMR) at transition metal interfaces: case of (Co/Pt) (Conference Presentation)

NASA Astrophysics Data System (ADS)

Jaffres, Henri; George, Jean-Marie; Laczowski, Piotr; Reyren, Nicolas; Vila, Laurent

2016-10-01

Spintronic phenomena are made possible via the diffusion of spin-currents or the generation of spin-accumulation. Spinorbitronics uses the electronic spin-orbit coupling (SOC) and emerges as a new route to create spin-currents in the transverse direction of the charge flow. This is made possible via the intrinsic spin Hall conduction (SHE) of heavy metals or extrinsic spin-Hall effect of metallic alloys. SHE borrows its concept from the anomalous Hall effect (AHE) where the relativistic spin-orbit coupling (SOC) promotes an asymmetric deflection of the spin-current. SHE is now at the base of magnetization commutation and domain wall moving via spin-orbit torque (SOT) and spin-transfer torque operations in the FMR regime. However, the exact anatomy of SOT at spin-orbit active interfaces like Co/Pt is still missing. In the case of Pt, recent studies have put forward the major role played by i) the spin-memory loss (SML) and the electronic transparency at 3d/5d interfaces and ii) the inhomogeneity of the conductivity in the current-in-plane (CIP) geometry to explain the discrepancy in the SHE. Ingredients to consider then are the profiles of both the conductivity and spin-current across the multilayers and spin-transmission. In this talk, we will present robust SMR measurements observed on NiCo/Pt multilayer stacks characterized by a perpendicular magnetic anisotropy (PMA). The SMR occurs for both in-plane magnetization rotation or from nominal out-of-plane to the in-plane direction transverse to the current flow. This clearly departs from standard AMR or pure interfacial anisotropic-AMR symmetries. We analyze in large details our SMR signals for the whole series of samples owing to two main guidelines: i) we consider the exact conductivity profile across the multilayers, in particular near the Co/Pt interface, via the Camley-Barnas approach and ii) we derive the spin current profile generated by SHE along the perpendicular direction responsible for SMR. We consider pure interfacial spin dissipation by SML (decoherence, interfacial enhanced scattering) and give out a general analytical expression for SMR. Our conclusions go towards a robust value of the spin-Hall conductivity and SML like previously published. The CIP spin-Hall angle, of the order of 0.10 is larger than the one found in spin-pumping experiments (CPP geometry) owing to the smaller conductivity at the Co/Pt interface, in agreement with the results of STT-FMR experiments.

A novel method for quantifying the amount of trabecular meshwork pigment in glaucomatous and nonglaucomatous eyes.

PubMed

Kinori, Michael; Hostovsky, Avner; Skaat, Alon; Schwartsman, Jonathan; Melamed, Shlomo

2014-01-01

To assess the use of a computerized program for evaluating the amount of trabecular meshwork (TM) pigmentation in normal (control), primary open-angle glaucoma (POAG), and pseudoexfoliation glaucoma/pigmentary dispersion glaucoma (PXFG/PDG) patients. All included patients were from the Goldschleger Eye Institute glaucoma clinic. After signing an informed consent, each patient's anterior chamber angle was photographed using a single photo-slit under the same conditions. Only one eye per patient was photographed. The superior TM and the inferior TM were documented. Then, the degree of "blackness" (representing melanin pigment) was assessed using the ImageJ program. Of the 43 eyes photographed, 8 were excluded because of low-quality images. Of the remaining 35 patients, 14 were normal, 10 had POAG, and 11 had PXFG/PDG. The amount of pigment was the same in the control and the POAG patients whether the inferior TM (P=0.24), superior TM (P=0.58), or the sum inferior TM+superior TM (P=0.85) was measured. The pigment level was significantly higher in the PXFG/PDG group than in the control group (inferior TM, P<0.01; superior TM, P=0.047; sum, P<0.01). The difference between the inferior and the superior TM pigment levels was found to be statistically insignificant in all the groups (normal, P=0.86; POAG, P=0.10; PXFG/PDG, P=0.22). The use of ImageJ software might play a role in the quantification of pigment evaluation of the TM.

OncoLogicTM

EPA Science Inventory

OncoLogic^TM - A Computer System to Evaluate the Carcinogenic Potential of Chemicals
OncoLogic^TM is a software program that evaluates the likelihood that a chemical may cause cancer. OncoLogic^TM has been peer reviewed and is being rele...

Changes in vegetation spectra with deterioration of leaves under two methods of preservation

NASA Technical Reports Server (NTRS)

Labovitz, M. L.; Masuoka, E. J.; Feldmann, S. G.

1981-01-01

An experiment to measure changes in leaf spectra under different methods of preservation over time was conducted. The spectral measurements were made by a three band hand held radiometer which simulated three Thematic Mapper (TM) bands: TM3, TM4, and TM5. Daily spectral measurements of white oak leaves under three preservation treatments were made. The spectral readings over three treatments (fresh, bottled, and bagged vegetation) were indistinguishable in bands TM3 and TM5 for up to 4 days after collection. After that time bagged and bottled samples showed significant increases in reflected energy caused by loss of chlorophyll from and dehydration of the vegetation. No significant variation in the reflectance values from TM4 over preservation type for the experimental period was observed.

Neutralizing Epitopes in the Membrane-Proximal External Region of HIV-1 gp41 Are Influenced by the Transmembrane Domain and the Plasma Membrane

PubMed Central

Montero, Marinieve; Klaric, Kristina-Ana; Donald, Jason E.; Lepik, Christa; Wu, Sampson; Tsai, Sue; Julien, Jean-Philippe; Hessell, Ann J.; Wang, Shixia; Lu, Shan; Burton, Dennis R.; Pai, Emil F.; DeGrado, William F.

2012-01-01

Failure to elicit broadly neutralizing (bNt) antibodies (Abs) against the membrane-proximal external region of HIV-1 gp41 (MPER) reflects the difficulty of mimicking its neutralization-competent structure (NCS). Here, we analyzed MPER antigenicity in the context of the plasma membrane and identified a role for the gp41 transmembrane domain (TM) in exposing the epitopes of three bNt monoclonal Abs (MAbs) (2F5, 4E10, and Z13e1). We transiently expressed DNA constructs encoding gp41 ectodomain fragments fused to either the TM of the platelet-derived growth factor receptor (PDGFR) or the gp41 TM and cytoplasmic tail domain (CT). Constructs encoding the MPER tethered to the gp41 TM followed by a 27-residue CT fragment (MPER-TM1) produced optimal MAb binding. Critical binding residues for the three Nt MAbs were identified using a panel of 24 MPER-TM1 mutants bearing single amino acid substitutions in the MPER; many were previously shown to affect MAb-mediated viral neutralization. Moreover, non-Nt mutants of MAbs 2F5 and 4E10 exhibited a reduction in binding to MPER-TM1 and yet maintained binding to synthetic MPER peptides, indicating that MPER-TM1 better approximates the MPER NCS than peptides. Replacement of the gp41 TM and CT of MPER-TM1 with the PDGFR TM reduced binding by MAb 4E10, but not 2F5, indicating that the gp41 TM plays a pivotal role in orienting the 4E10 epitope, and more globally, in affecting MPER exposure. PMID:22238313

Thrombomodulin Contributes to Gamma Tocotrienol-Mediated Lethality Protection and Hematopoietic Cell Recovery in Irradiated Mice

PubMed Central

Pathak, Rupak; Shao, Lijian; Ghosh, Sanchita P.; Zhou, Daohong; Boerma, Marjan; Weiler, Hartmut; Hauer-Jensen, Martin

2015-01-01

Systemic administration of recombinant thrombomodulin (TM) confers radiation protection partly by accelerating hematopoietic recovery. The uniquely potent radioprotector gamma tocotrienol (GT3), in addition to being a strong antioxidant, inhibits the enzyme hydroxy-methyl-glutaryl-coenzyme A reductase (HMGCR) and thereby likely modulates the expression of TM. We hypothesized that the mechanism underlying the exceptional radioprotective properties of GT3 partly depends on the presence of endothelial TM. In vitro studies confirmed that ionizing radiation suppresses endothelial TM (about 40% at 4 hr after 5 Gy γ-irradiation) and that GT3 induces TM expression (about 2 fold at the mRNA level after 5 μM GT3 treatment for 4 hr). In vivo survival studies showed that GT3 was significantly more effective as a radioprotector in TM wild type (TM+/+) mice than in mice with low TM function (TMPro/-). After exposure to 9 Gy TBI, GT3 pre-treatment conferred 85% survival in TM+/+ mice compared to only 50% in TMPro/-. Thus, GT3-mediated radiation lethality protection is partly dependent on endothelial TM. Significant post-TBI recovery of hematopoietic cells, particularly leukocytes, was observed in TM+/+ mice (p = 0.003), but not in TMPro/- mice, despite the fact that GT3 induced higher levels of granulocyte colony stimulating factor (G-CSF) in TMPro/- mice (p = 0.0001). These data demonstrate a critical, G-CSF-independent, role for endothelial TM in GT3-mediated lethality protection and hematopoietic recovery after exposure to TBI and may point to new strategies to enhance the efficacy of current medical countermeasures in radiological/nuclear emergencies. PMID:25860286

Short-Term Safety and Efficacy of Femoral Vascular Closure after Percutaneous Coronary Intervention with Combination of the Boomerang(TM) Device and Intravenous Protamine Sulfate.

PubMed

Chen, Ching-Pei; Huang, Huang-Kai; Hsia, Chien-Hsun; Chang, Yung-Ming; Lin, Lee-Shin; Lee, Cheng-Liang

2013-11-01

The Cardiva Boomerang(TM) is a device used to perform femoral vascular closure. It facilitates passive hemostasis at the arteriotomy site, leaving no residual foreign body. We performed a controlled, randomized study of 60 patients undergoing percutaneous coronary intervention. Patients were randomized into two groups (30 per group) to undergo vascular closure with the Boomerang(TM) or the Perclose(TM) suture-based device after the intravenous administration of protamine sulfate. We compared overall success rates, patient-reported pain, length of time to achieve hemostasis and mobilization of the patient, and the frequency of complications in the two groups. Overall success rates using the Boomerang(TM) and Perclose(TM) devices were similarly high, at 93% and 97%, respectively. The Boomerang(TM) was significantly quicker to deploy than the PercloseTM, device deployment time, median (Q1-Q3), [2.00 (1.33-2.75) vs. 3.84 (2.75-4.38) mins, p < 0.001)]. The pain score was significantly lower in the Boomerang(TM) group (1.1 ± 1.7 vs. 6.4 ± 2.9, p < 0.001). The time the device remained in the artery and manual compression time were significantly longer with the Boomerang(TM) (p < 0.001), as well as the time taken to achieve hemostasis and time to ambulation. There were no major complications in either group and no significant differences between the groups in the frequency of minor complications. We conclude that when used in combination with intravenous protamine sulfate, the Boomerang(TM) device is as safe and effective as the Perclose(TM) device for femoral vascular closure, but quicker to deploy and less painful to patients. Boomerang; Percutaneous intervention; Vascular closure device.

[Study of serum thrombomodulin(TM) levels in patients with hyper- or hypo- thyroidism].

PubMed

Soma, M; Maeda, Y; Matsuura, R; Sasaki, I; Kasakura, S; Saeki, Y; Ikekubo, K; Ishihara, T; Kurahachi, H; Sasaki, S; Tagami, T; Nakao, K

1997-01-01

We studies a relationship between the serum levels of thrombomodulin(TM) and the thyroid functions. Serum TM levels were measured in 48 patients with Graves' disease, 17 patients with primary hypothyroidism, 7 patients with subacute thyroiditis, 5 patients with painless thyroiditis and 2 patients with systematic Refetoff syndrome. These patients did not have malignant tumor, kidney failure, or blood vessel injury. Control sera were obtained from 42 healthy subjects. Serum levels of TM in patients with untreated Graves' disease were significantly higher(p < 0.001) compared with those in controls. Serum levels of TM in patients with hypothyroidism were not significantly changed as compared with those of controls. There were a positive correlation between the serum levels of TM and FT3 as well as FT4. Serial determinations of the serum levels of TM and thyroid function(FT3, FT4 and TH) in patients with Graves' disease during treatment showed that both the serum levels of TM and thyroid hormones (FT3 and FT4) lowered progressively during treatment. After normalization of serum FT3 and FT4, the serum TM levels returned to normal. However, the serum levels of TM in patients with destructive thyroiditis and Refetoff syndrome were normal in spite of high serum levels of thyroid hormones. These data suggest that an increase in serum levels of TM is not the direct result of thyroid hormones themselves but is the result of the prolonged hypermetabolic state induced by their peripheral activities. Thyroid hormones may stimulate the synthesis or metabolism of TM on the surface of vascular endothelial cells in the patients with Graves' disease.

Evidence-based guideline: clinical evaluation and treatment of transverse myelitis: report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology.

PubMed

Scott, T F; Frohman, E M; De Seze, J; Gronseth, G S; Weinshenker, B G

2011-12-13

To assess the evidence for diagnostic tests and therapies for transverse myelitis (TM) and make evidence-based recommendations. A review of the published literature from 1966 to March 2009 was performed, with evidence-based classification of relevant articles. Level B recommendations: neuromyelitis optica (NMO)-immunoglobulin G (IgG) antibodies should be considered useful to determine TM cause in patients presenting with clinical acute complete transverse myelitis (ACTM) features. The presence of NMO-IgG antibodies (aquaporin-4-specific antibodies) should be considered useful in determining increased TM recurrence risk. Level C recommendations: in suspected TM, distinction between ACTM or acute partial transverse myelitis may be considered useful to determine TM etiology and risk for relapse (more common with APTM). Age and gender may be considered useful to determine etiology in patients presenting with TM syndrome, with spinal infarcts seen more often in older patients and more female than male patients having TM due to multiple sclerosis (MS). Brain MRI characteristics consistent with those of MS may be considered useful to predict conversion to MS after a first partial TM episode. Longer spinal lesions extending over >3 vertebral segments may be considered useful in determining NMO vs MS. CSF examination for cells and oligoclonal bands may be considered useful to determine the cause of the TM syndrome. Plasma exchange may be considered in patients with TM who fail to improve after corticosteroid treatment. Rituximab may be considered in patients with TM due to NMO to decrease the number of relapses. Level U recommendations: there is insufficient evidence to support or refute the efficacy of other TM therapies or the usefulness of ethnicity to determine the cause of a subacute myelopathy.

Correlations between Transmembrane 4 L6 Family Member 5 (TM4SF5), CD151, and CD63 in Liver Fibrotic Phenotypes and Hepatic Migration and Invasive Capacities

PubMed Central

Kang, Minkyung; Ryu, Jihye; Lee, Doohyung; Lee, Mi-Sook; Kim, Hye-Jin; Nam, Seo Hee; Song, Haeng Eun; Choi, Jungeun; Lee, Gyu-Ho; Kim, Tai Young; Lee, Hansoo; Kim, Sang Jick; Ye, Sang-Kyu; Kim, Semi; Lee, Jung Weon

2014-01-01

Transmembrane 4 L6 family member 5 (TM4SF5) is overexpressed during CCl4-mediated murine liver fibrosis and in human hepatocellular carcinomas. The tetraspanins form tetraspanin-enriched microdomains (TEMs) consisting of large membrane protein complexes on the cell surface. Thus, TM4SF5 may be involved in the signal coordination that controls liver malignancy. We investigated the relationship between TM4SF5-positive TEMs with liver fibrosis and tumorigenesis, using normal Chang hepatocytes that lack TM4SF5 expression and chronically TGFβ1-treated Chang cells that express TM4SF5. TM4SF5 expression is positively correlated with tumorigenic CD151 expression, but is negatively correlated with tumor-suppressive CD63 expression in mouse fibrotic and human hepatic carcinoma tissues, indicating cooperative roles of the tetraspanins in liver malignancies. Although CD151 did not control the expression of TM4SF5, TM4SF5 appeared to control the expression levels of CD151 and CD63. TM4SF5 interacted with CD151, and caused the internalization of CD63 from the cell surface into late lysosomal membranes, presumably leading to terminating the tumor-suppressive functions of CD63. TM4SF5 could overcome the tumorigenic effects of CD151, especially cell migration and extracellular matrix (ECM)-degradation. Taken together, TM4SF5 appears to play a role in liver malignancy by controlling the levels of tetraspanins on the cell surface, and could provide a promising therapeutic target for the treatment of liver malignancies. PMID:25033048

Spectroscopy and microchip laser operation of Tm, Ho:KYW crystals with different Ho concentrations

NASA Astrophysics Data System (ADS)

Gusakova, N. V.; Kurilchik, S. V.; Yasukevich, A. S.; Kisel, V. E.; Dashkevich, V. I.; Orlovich, V. A.; Pavlyuk, A. A.; Vatnik, S. M.; Bagaev, S. N.; Kuleshov, N. V.

2018-02-01

The spectroscopic properties of Tm, Ho:KYW crystals with different Ho concentrations were investigated. The diode-pumped microchip laser operation of Tm (5 at.%), Ho (0.5 at.%):KYW and Tm (5 at.%), Ho (1 at.%):KYW was demonstrated. The highest, to our knowledge, output power of 480 mW with slope efficiency of 31% for CW Tm (5 at.%), Ho (0.5 at.%):KYW microchip laser was obtained.

Community pharmacist's responsibilities with regards to traditional medicine/complementary medicine products: A systematic literature review.

PubMed

Ung, Carolina Oi Lam; Harnett, Joanna; Hu, Hao

The use of Traditional Medicine/Complementary Medicine (TM/CM) products has gained popularity in many countries. There is a growing body of evidence to support that concomitant use of TM/CM products with certain pharmaceutical medicines may adversely affect treatment outcomes. There is a general consensus that pharmacists have a role to play in the safe and appropriate use of these products. However, the extent of their involvement and responsibilities are not yet defined. Clear guidelines that inform their duty of care are essential for pharmacists to establish their role in the management of TM/CM product use. The purpose of this study was to determine pharmacist's responsibilities with regards to TM/CM products that have been discussed in the literature since 2000. A literature search in 3 electronic databases (Web of Science, Science Direct and PubMed) was used to extract publications from 2000 to 2015 that related pharmacist to TM/CM products. Out of the 2859 publications extracted for abstract review, 171 documents were selected for full text assessment. 41 publications which reported findings from exploratory studies or discussed pharmacists' responsibilities towards TM/CM products were selected for inclusion in this study. Seven major responsibilities were frequently discussed in the literature: (1) to acknowledge the use; (2) to be knowledgeable about the TM/CM products; (3) to ensure safe use of TM/CM products; (4) to document the use of TM/CM products; (5) to report ADRs related to TM/CM products; (6) to educate about TM/CM products; and (7) to collaborate with other health care professionals. Various forms and levels of pharmacists' responsibilities with TM/CM products have been mentioned in the literature. Subsequent work towards a common consensus must take into account three influential factors strategically: the scope of TM/CM products, objectives of pharmacists' involvement and the perspectives of key stakeholders. Copyright © 2016 Elsevier Inc. All rights reserved.

Modified LaRC(TM)-IA Polyimides

NASA Technical Reports Server (NTRS)

St. Clair, Terry L.; Chang, Alice C.; Hou, Tan H.; Working, Dennis C.

1994-01-01

Modified versions of thermoplastic polyimide LaRC(TM)-IA incorporate various amounts of additional, rigid moieties into backbones of LaRC(TM)-IA molecules. Modified versions more resistant to solvents and exhibit higher glass-transition temperatures, yet retain melt-flow processability of unmodified LaRC(TM)-IA.

Thematic Mapper Data Quality and Performance Assessment in Renewable Resources/agriculture/remote Sensing

NASA Technical Reports Server (NTRS)

Bizzell, R. M.; Prior, H. L.

1985-01-01

Analysis of the early thematic mapper (TM) data indicate the TM sensor and associated ground processing are performing equal to the high expectations and within advertised specifications. The overall TM system with improved resolution, together with additional and more optimumly placed spectral bands shows much promise for benefits in future analysis activities. By selecting man-made features of known dimensions (e.g., highways, airfields, buildings, and isolated water bodies), an assessment was made of the TM performance relative to the specified 30-meter (98-foot) resolution. The increase of spatial resolution of TM (30 m) over MSS (80 M) appears to be significant not only in resolving spectrally distinct classes that were previously undefinable but also in distinguishing within-field variability. An Important result of the early TM evaluation and pre-TM analyses was the development of an integrated system to receive LANDSAT-4 TM (as well as MSS) data and analyze the data via various approaches.

The tearing mode locking-unlocking mechanism to an external resonant field in EXTRAP T2R

NASA Astrophysics Data System (ADS)

Frassinetti, L.; Fridström, R.; Menmuir, S.; Brunsell, P. R.

2014-10-01

The tearing mode (TM) locking and unlocking process due to an external resonant magnetic perturbation (RMP) is experimentally studied in EXTRAP T2R. The RMP produces a reduction of the natural TM velocity and ultimately the TM locking if a threshold in the RMP amplitude is exceeded. During the braking process, the TM slows down via a mechanism composed of deceleration and acceleration phases. During the acceleration phases, the TM can reach velocities higher than the natural velocity. Once the TM locking occurs, the RMP must be reduced to a small amplitude to obtain the TM unlocking, showing that the unlocking threshold is significantly smaller than the locking threshold and that the process is characterized by hysteresis. Experimental results are in qualitative agreement with a model that describes the locking-unlocking process via the balance of the electromagnetic torque produced by the RMP that acts to brake the TM and the viscous torque that tends to re-establish the unperturbed velocity.

Percutaneous toxicity and decontamination of soman, VX, and paraoxon in rats using detergents.

PubMed

Misík, Jan; Pavliková, Růžena; Kuča, Kamil

2013-06-01

Highly toxic organophosphorus compounds (OPs) were originally developed for warfare or as agricultural pesticides. Today, OPs represent a serious threat to military personnel and civilians. This study investigates the in vivo decontamination of male Wistar rats percutaneously exposed to paraoxon and two potent nerve agents--soman (GD) and VX. Four commercial detergents were tested as decontaminants--Neodekont(TM), Argos(TM), Dermogel(TM), and FloraFree(TM). Decontamination performed 2 min after exposure resulted in a higher survival rate in comparison with non-decontaminated controls. The decontamination effectiveness was expressed as protective ratio (PR, median lethal dose of agent in decontaminated animals divided by the median lethal dose of agent in untreated animals). The highest decontamination effectiveness was consistently achieved with Argos(TM) (PR=2.3 to 64.8), followed by Dermogel(TM) (PR=2.4 to 46.1). Neodekont(TM) and FloraFree(TM) provided the lowest decontamination effectiveness, equivalent to distilled water (PR=1.0 to 43.2).

Magnetic ordering in TmGa.

PubMed

Cadogan, J M; Stewart, G A; Muñoz Pérez, S; Cobas, R; Hansen, B R; Avdeev, M; Hutchison, W D

2014-03-19

We have determined the magnetic structure of the intermetallic compound TmGa by high-resolution neutron powder diffraction and (169)Tm Mössbauer spectroscopy. This compound crystallizes in the orthorhombic (Cmcm) CrB-type structure and its magnetic structure is characterized by magnetic order of the Tm sublattice along the a-axis. The initial magnetic ordering occurs at 15(1) K and yields an incommensurate antiferromagnetic structure described by the propagation vector k1 = [0 0.275(2) 0]. At 12 K the dominant ferromagnetic ordering of the Tm sublattice along the a-axis develops in what appears to be a first-order transition. At 3 K the magnetic structure of TmGa is predominantly ferromagnetic but a weakened incommensurate component remains. The ferromagnetic Tm moment reaches 6.7(2) μB at 3 K and the amplitude of the remaining incommensurate component is 2.7(4) μB. The (169)Tm hyperfine magnetic field at 5 K is 631(1) T.

The recruitment of acetylated and unacetylated tropomyosin to distinct actin polymers permits the discrete regulation of specific myosins in fission yeast

PubMed Central

Coulton, Arthur T.; East, Daniel A.; Galinska-Rakoczy, Agnieszka; Lehman, William; Mulvihill, Daniel P.

2010-01-01

Tropomyosin (Tm) is a conserved dimeric coiled-coil protein, which forms polymers that curl around actin filaments in order to regulate actomyosin function. Acetylation of the Tm N-terminal methionine strengthens end-to-end bonds, which enhances actin binding as well as the ability of Tm to regulate myosin motor activity in both muscle and non-muscle cells. In this study we explore the function of each Tm form within fission yeast cells. Electron microscopy and live cell imaging revealed that acetylated and unacetylated Tm associate with distinct actin structures within the cell, and that each form has a profound effect upon the shape and integrity of the polymeric actin filament. We show that, whereas Tm acetylation is required to regulate the in vivo motility of class II myosins, acetylated Tm had no effect on the motility of class I and V myosins. These findings illustrate a novel Tm-acetylation-state-dependent mechanism for regulating specific actomyosin cytoskeletal interactions. PMID:20807799

The use of radiation-induced graft polymerization for modification of polymer track membranes

NASA Astrophysics Data System (ADS)

Shtanko, N. I.; Kabanov, V. Ya.; Apel, P. Yu.; Yoshida, M.

1999-05-01

Track membranes (TM) made of poly(ethylene terephtalate) (PET) and polypropylene (PP) films have a number of peculiarities as compared with other ones. They have high mechanical strength at a low thickness, narrow pore size distribution, low content of extractables. However, TM have some disadvantages such as low chemical resistance in alkaline media (PET TM), the low water flow rate due to the hydrophobic nature of their surface. The use of radiation-induced graft polymerization makes it possible to improve the basic characteristics of TM. In this communication our results on the modification of PET and PP TM are presented. The modified membranes were prepared by radiation-induced graft polymerization from the liquid phase. Three methods of grafting were used: (a) the direct method in argon atmosphere; (b) the pre-irradiation of TM in air followed by grafting in argon atmosphere; (c) pre-irradiation in vacuum followed by grafting in vacuum without contacting oxygen. The aim of the work was to investigate some properties of TM modified by grafted poly(methylvinyl pyridine) (PMVP) and poly(N-isopropylacrylamide) (PNIPAAM). It was shown that the modification of TM with hydrophilic polymer results in the growth of the water flow rate. In the past few years many works have been devoted to the synthesis of new polymers - the so-called "intelligent" materials - such as PNIPAAM. However, it is very difficult to make thin membranes of this polymer. Recently, it has been proposed to manufacture composite membranes by grafting stimulus-responsive polymers onto TM. Following this principle, we prepared thermosensitive membranes by the radiation-induced graft polymerization of N-isopropylacrylamide (NIPAAM) onto PET TM. PET TM with the pore size of about 1 μm and pore density of 10 6 cm -2 were first inserted into a solution of NIPAAM containing inhibitor of homopolymerization (CuCl 2) and then exposed to the γ-rays from a 60Co source. The transport properties of the grafted TM were investigated. The permeation of water through the TM was controlled by temperature. The grafted TM exhibited almost the same transition temperature (about 33°C) as that of PNIPAAM.

Optical connections on flexible substrates

NASA Astrophysics Data System (ADS)

Bosman, Erwin; Geerinck, Peter; Christiaens, Wim; Van Steenberge, Geert; Vanfleteren, Jan; Van Daele, Peter

2006-04-01

Optical interconnections integrated on a flexible substrate combine the advantages of optical data transmissions (high bandwidth, no electromagnetic disturbance and low power consumption) and those of flexible substrates (compact, ease of assembly...). Especially the flexible character of the substrates can significantly lower the assembly cost and leads to more compact modules. Especially in automotive-, avionic-, biomedical and sensing applications there is a great potential for these flexible optical interconnections because of the increasing data-rates, increasing use of optical sensors and requirement for smaller size and weight. The research concentrates on the integration of commercially available polymer optical layers (Truemode Backplane TM Polymer, Ormocer®) on a flexible Polyimide film, the fabrication of waveguides and out-of plane deflecting 45° mirrors, the characterization of the optical losses due to the bending of the substrate, and the fabrication of a proof-of-principal demonstrator. The resulting optical structures should be compatible with the standard fabrication of flexible printed circuit boards.

Metastable phase formation in the Au-Si system via ultrafast nanocalorimetry

NASA Astrophysics Data System (ADS)

Zhang, M.; Wen, J. G.; Efremov, M. Y.; Olson, E. A.; Zhang, Z. S.; Hu, L.; de la Rama, L. P.; Kummamuru, R.; Kavanagh, K. L.; Ma, Z.; Allen, L. H.

2012-05-01

We have investigated the stability and solidification of nanometer size Au-Si droplets using an ultrafast heating/cooling nanocalorimetry and in situ growth techniques. The liquid can be supercooled to very low temperatures for both Au-rich (ΔT ˜ 95 K) and Si-rich (ΔT ˜ 220 K) samples. Solidification of a unique metastable phase δ1 is observed with a composition of 74 ± 4 at. % Au and a b-centered orthorhombic structure (a = 0.92, b = 0.72, and c = 1.35 nm; body-center in the a-c plane), which grows heteroepitaxially to Aus. Its melting temperature Tm is 305 ± 5 °C. There is competition during formation between the eutectic and δ1 phases but δ1 is the only metastable alloy observed. For small size droplets, both the δ1 and eutectic phases show considerable depression of the melting point (size-dependent melting).

Structure-based membrane dome mechanism for Piezo mechanosensitivity

PubMed Central

Guo, Yusong R

2017-01-01

Mechanosensitive ion channels convert external mechanical stimuli into electrochemical signals for critical processes including touch sensation, balance, and cardiovascular regulation. The best understood mechanosensitive channel, MscL, opens a wide pore, which accounts for mechanosensitive gating due to in-plane area expansion. Eukaryotic Piezo channels have a narrow pore and therefore must capture mechanical forces to control gating in another way. We present a cryo-EM structure of mouse Piezo1 in a closed conformation at 3.7Å-resolution. The channel is a triskelion with arms consisting of repeated arrays of 4-TM structural units surrounding a pore. Its shape deforms the membrane locally into a dome. We present a hypothesis in which the membrane deformation changes upon channel opening. Quantitatively, membrane tension will alter gating energetics in proportion to the change in projected area under the dome. This mechanism can account for highly sensitive mechanical gating in the setting of a narrow, cation-selective pore. PMID:29231809

Spectroscopic, luminescent and laser properties of nanostructured CaF2:Tm materials

NASA Astrophysics Data System (ADS)

Lyapin, A. A.; Fedorov, P. P.; Garibin, E. A.; Malov, A. V.; Osiko, V. V.; Ryabochkina, P. A.; Ushakov, S. N.

2013-08-01

The laser quality transparent СаF2:Tm fluoride ceramics has been prepared by hot forming. Comparative study of absorption and emission spectra of СаF2:Tm (4 mol.% TmF3) ceramic and single crystal samples demonstrated that these materials possess almost identical spectroscopic properties. Laser oscillations of СаF2:Tm ceramics were obtained at 1898 nm under diode pumping, with the slope efficiency of 5.5%. Also, the continuous-wave (CW) laser have been obtained for СаF2:Tm single crystal at 1890 nm pumped by a diode laser was demonstrated.

Investigations of LRE-HRE-TM thin films for hybrid recording

NASA Astrophysics Data System (ADS)

Li, Zuoyi; Cheng, Xiaomin; Jin, Fang; Li, Zhen; Lin, Gengqi; Yang, Xiaofei

2005-09-01

Light rare earth-heavy rare earth-transition metal (LRE-HRE-TM) thin films are a kind of important recording media. A lot of researches have been carried out on the LRE-HRE-TM thin films to improve its properties for data storage application and fruitful results have been achieved. This report gives a glance on the evolution of the research on LRE-HRE-TM recording media. At the same time, combined with the hybrid recording technology, some experimental results obtained on LRE-HRE-TM recording media are discussed, which suggest the promising prospect of the LRE-HRE-TM media in hybrid recording application.

Pharmacological Differentiation of Thrombomodulin Alfa and Activated Protein C on Coagulation and Fibrinolysis In Vitro.

PubMed

Tanaka, Kosuke; Tawara, Shunsuke; Tsuruta, Kazuhisa; Hoppensteadt, Debra; Fareed, Jawed

2018-01-01

Although thrombomodulin alfa (TM alfa), recombinant human soluble thrombomodulin, exerts antithrombogenic effects through activated protein C (APC), clinical trials suggested that TM alfa has a lower bleeding risk than does recombinant human APC. To address the mechanism explaining this difference, effects of TM alfa and APC on thrombogenic, coagulation, and fibrinolytic processes were compared in vitro. TM alfa and APC inhibited generation of thrombogenic markers, thrombin, and prothrombin fragment F1+2 and prolonged coagulation parameters, activated clotting time (ACT), and activated partial thromboplastin time (APTT). Concentrations of TM alfa effective for thrombin and F1+2 generation inhibition were comparable to those of APC. However, effects of TM alfa on ACT and APTT were clearly weaker than those of APC. TM alfa significantly prolonged clot lysis time (CLT) and decreased LY30, a parameter of degree of fibrinolysis in thromboelastography, whereas APC significantly shortened CLT and increased LY30. These results suggested that while the antithrombogenic effects of TM alfa were similar to those of APC, its anticoagulant effects were lower. In addition, effects of TM alfa were antifibrinolytic, while those of APC were profibrinolytic.

Optical image modulation above the submarine bottom topography: a case study on the Taiwan Banks, China

NASA Astrophysics Data System (ADS)

Li, Yan; Hu, Jianyu; Li, Jing; Fu, Bin; Ma, Liming

2003-05-01

A possible mechanism to explain the correlation between submarine topography and the direct sunlight specially reflected from the sea surface with variable roughness caused by the bottom-current effect was suggested fifteen years ago by Henning et al. in International Journal of Remote Sensing, 9, 45-67, after comparing radar satellite image and Skylab satellite photograph of the North American east coast (Nantucket Shoals) with submarine relief features. A case study is carried out in the famous sand waves field located at the Taiwan banks of Taiwan Strait in August 1998. The TM images, either visible bands (TM1, TM2, TM3) or near infrared bands (TM4, TM5, TM7), shows submarine relief features for sand waves, with wavelength of 300 to 2000 meters, riding on the lager scale sand ridges and channel system. Sea truth data including 660 nm beam attenuation coefficient profiles were conducted in the same period. We compare signals of TM images, attenuation coefficient profiles, and sounding maps of the Taiwan Bands. The subsurface upwelling signals with contributions of the water column and the bottom, either estimated by single or quasi-single-scattering theory or revealed by the TM images after removing the contribution of direct sunlight reflected signals from sea surface, were too weak to distinguish the ridges and troughs of bedforms especially for red and near infrared bands. However, the direct sunlight specially reflected signals from the sea surface, approximately at same level in water-leaving reflectance not only for visible bands (TM1, TM2, TM3) but also for near infrared bands (TM4, TM5, TM7), was the major submarine bottom topography signals especially for those pixels towards the direction of the sun azimuth. Following a physical description for the lee waves appeared on free surface when the current flows round an underwater obstacle, the direct sunlight reflected signals related wave face slope, is dominated by the height and depth of sand waves and sand ridges, and current speed of the flows over those bedforms. The direct sunlight reflected signals from the sea surface could be regarded as a powerful tool to detect bedforms and other underwater obstacles.

Freeze-thaw decellularization of the trabecular meshwork in an ex vivo eye perfusion model

PubMed Central

Dang, Yalong; Waxman, Susannah; Wang, Chao; Jensen, Adrianna; Loewen, Ralitsa T.; Bilonick, Richard A.

2017-01-01

Objective The trabecular meshwork (TM) is the primary substrate of outflow resistance in glaucomatous eyes. Repopulating diseased TM with fresh, functional TM cells might be a viable therapeutic approach. Decellularized TM scaffolds have previously been produced by ablating cells with suicide gene therapy or saponin, which risks incomplete cell removal or dissolution of the extracellular matrix, respectively. We hypothesized that improved trabecular meshwork cell ablation would result from freeze-thaw cycles compared to chemical treatment. Materials and Methods We obtained 24 porcine eyes from a local abattoir, dissected and mounted them in an anterior segment perfusion within two hours of sacrifice. Intraocular pressure (IOP) was recorded continuously by a pressure transducer system. After 72 h of IOP stabilization, eight eyes were assigned to freeze-thaw (F) ablation (−80 °C × 2), to 0.02% saponin (S) treatment, or the control group (C), respectively. The TM was transduced with an eGFP expressing feline immunodeficiency viral (FIV) vector and tracked via fluorescent microscopy to confirm ablation. Following treatment, the eyes were perfused with standard tissue culture media for 180 h. TM histology was assessed by hematoxylin and eosin staining. TM viability was evaluated by a calcein AM/propidium iodide (PI) assay. The TM extracellular matrix was stained with Picro Sirius Red. We measured IOP and modeled it with a linear mixed effects model using a B-spline function of time with five degrees of freedom. Results F and S experienced a similar IOP reduction of 30% from baseline (P = 0.64). IOP reduction of about 30% occurred in F within 24 h and in S within 48 h. Live visualization of eGFP demonstrated that F conferred a complete ablation of all TM cells and only a partial ablation in S. Histological analysis and Picro Sirius staining confirmed that no TM cells survived in F while the extracellular matrix remained. The viability assay showed very low PI and no calcein staining in F in contrast to many PI-labeled, dead TM cells and calcein-labeled viable TM cells in S. Conclusion We developed a rapid TM ablation method that uses cyclic freezing that is free of biological or chemical agents and able to produce a decellularized TM scaffold with preserved TM extracellular matrix in an organotypic perfusion culture. PMID:28828244

37 CFR 102.34 - Specific exemptions.

Code of Federal Regulations, 2012 CFR

2012-07-01

.../DEPT-14; (D) Attorneys and Agents Registered to Practice Before the Office—COMMERCE/PAT-TM-1; (E... OF COMMERCE ADMINISTRATION DISCLOSURE OF GOVERNMENT INFORMATION Privacy Act § 102.34 Specific... are within this exemption are: COMMERCE/PAT-TM-6, COMMERCE/PAT-TM-7, COMMERCE/PAT-TM-8, COMMERCE/PAT...