Microcomputers and the Electrical Engineer.

DTIC Science & Technology

1984-07-01

B6 10*SIN(B4*B1I) 12 BII+B6 10*SIN(B4*812) 13 B12+B6 1O*SIN(B4*BI3) 14 B13+B6 10*SIN(B4*B14) 15 B14+B6 10*SIN(B4*BI5) 16 B15+B6 10*SIN(B4* Bl6 ) 17 B16 ...C15)),AND(D15,NOT(EI5 16 0 0 1 0 OR(AND( B16 ,NOT(C16)),AND(D16,NOT(E16 a17 0 0 0 1 OR(AND(B17,NOT(C17)),AND(D17,NOT(E17 18 0 0 0 0 OR(AND(B18,NOT(C18...NOT(E15)) 16 0 0 010 AND(AND( Bl6 ,NOT(Cl7)),AND(D16,NOT(E16)) 18 0) 0 0 0 AND(AND(B18,NOT(C18)),AND(D18,NOT(E18)) 19 Figure 3 I A IIBIJCIIDIIEII F I 1

Computational assessment of deep-seated tumor treatment capability of the 9Be(d,n)10B reaction for accelerator-based boron neutron capture therapy (AB-BNCT).

PubMed

Capoulat, M E; Minsky, D M; Kreiner, A J

2014-03-01

The 9Be(d,n)10B reaction was studied as an epithermal neutron source for brain tumor treatment through Boron Neutron Capture Therapy (BNCT). In BNCT, neutrons are classified according to their energies as thermal (<0.5 eV), epithermal (from 0.5 eV to 10 keV) or fast (>10 keV). For deep-seated tumors epithermal neutrons are needed. Since a fraction of the neutrons produced by this reaction are quite fast (up to 5-6 MeV, even for low-bombarding energies), an efficient beam shaping design is required. This task was carried out (1) by selecting the combinations of bombarding energy and target thickness that minimize the highest-energy neutron production; and (2) by the appropriate choice of the Beam Shaping Assembly (BSA) geometry, for each of the combinations found in (1). The BSA geometry was determined as the configuration that maximized the dose deliverable to the tumor in a 1 h treatment, within the constraints imposed by the healthy tissue dose adopted tolerance. Doses were calculated through the MCNP code. The highest dose deliverable to the tumor was found for an 8 μm target and a deuteron beam of 1.45 MeV. Tumor weighted doses ≥40 Gy can be delivered up to about 5 cm in depth, with a maximum value of 51 Gy at a depth of about 2 cm. This dose performance can be improved by relaxing the treatment time constraint and splitting the treatment into two 1-h sessions. These good treatment capabilities strengthen the prospects for a potential use of this reaction in BNCT. Copyright © 2013 Associazione Italiana di Fisica Medica. Published by Elsevier Ltd. All rights reserved.

SU-F-BRB-12: A Novel Haar Wavelet Based Approach to Deliver Non-Coplanar Intensity Modulated Radiotherapy Using Sparse Orthogonal Collimators

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nguyen, D; Ruan, D; Low, D

2015-06-15

Purpose: Existing efforts to replace complex multileaf collimator (MLC) by simple jaws for intensity modulated radiation therapy (IMRT) resulted in unacceptable compromise in plan quality and delivery efficiency. We introduce a novel fluence map segmentation method based on compressed sensing for plan delivery using a simplified sparse orthogonal collimator (SOC) on the 4π non-coplanar radiotherapy platform. Methods: 4π plans with varying prescription doses were first created by automatically selecting and optimizing 20 non-coplanar beams for 2 GBM, 2 head & neck, and 2 lung patients. To create deliverable 4π plans using SOC, which are two pairs of orthogonal collimators withmore » 1 to 4 leaves in each collimator bank, a Haar Fluence Optimization (HFO) method was used to regulate the number of Haar wavelet coefficients while maximizing the dose fidelity to the ideal prescription. The plans were directly stratified utilizing the optimized Haar wavelet rectangular basis. A matching number of deliverable segments were stratified for the MLC-based plans. Results: Compared to the MLC-based 4π plans, the SOC-based 4π plans increased the average PTV dose homogeneity from 0.811 to 0.913. PTV D98 and D99 were improved by 3.53% and 5.60% of the corresponding prescription doses. The average mean and maximal OAR doses slightly increased by 0.57% and 2.57% of the prescription doses. The average number of segments ranged between 5 and 30 per beam. The collimator travel time to create the segments decreased with increasing leaf numbers in the SOC. The two and four leaf designs were 1.71 and 1.93 times more efficient, on average, than the single leaf design. Conclusion: The innovative dose domain optimization based on compressed sensing enables uncompromised 4π non-coplanar IMRT dose delivery using simple rectangular segments that are deliverable using a sparse orthogonal collimator, which only requires 8 to 16 leaves yet is unlimited in modulation resolution. This work is supported in part by Varian Medical Systems, Inc. and NIH R43 CA18339.« less

Potential Replacements for Solvents that are Ozone Depleting Substances

DTIC Science & Technology

1994-09-01

18.4 d-Lumonene 17.8 Glidsafe-LUI54B 18.2 Turpentine 16.5 isobutyl acetate 17.2 Diisobutyl phthalate 18.3 Dipropylene glycol monomethyl ether 19.0...Diethylene glycol monomethyl ether 22.3 N- Methyl pyrrolidone 23.0 Water 47.8 1. Barton (1983): 2. Gallagher (date unknown). 9 TI DSTO-TR-0046 For blends...parameters. For example, Glidsafe UTS-4B which is a mixture of terpenes and dipropylene glycol monomethyl ether has a Hildebrand solubility of 18.2 MPal/ 2

Texture analysis on the fluence map to evaluate the degree of modulation for volumetric modulated arc therapy.

PubMed

Park, So-Yeon; Kim, Il Han; Ye, Sung-Joon; Carlson, Joel; Park, Jong Min

2014-11-01

Texture analysis on fluence maps was performed to evaluate the degree of modulation for volumetric modulated arc therapy (VMAT) plans. A total of six textural features including angular second moment, inverse difference moment, contrast, variance, correlation, and entropy were calculated for fluence maps generated from 20 prostate and 20 head and neck VMAT plans. For each of the textural features, particular displacement distances (d) of 1, 5, and 10 were adopted. To investigate the deliverability of each VMAT plan, gamma passing rates of pretreatment quality assurance, and differences in modulating parameters such as multileaf collimator (MLC) positions, gantry angles, and monitor units at each control point between VMAT plans and dynamic log files registered by the Linac control system during delivery were acquired. Furthermore, differences between the original VMAT plan and the plan reconstructed from the dynamic log files were also investigated. To test the performance of the textural features as indicators for the modulation degree of VMAT plans, Spearman's rank correlation coefficients (rs) with the plan deliverability were calculated. For comparison purposes, conventional modulation indices for VMAT including the modulation complexity score for VMAT, leaf travel modulation complexity score, and modulation index supporting station parameter optimized radiation therapy (MISPORT) were calculated, and their correlations were analyzed in the same way. There was no particular textural feature which always showed superior correlations with every type of plan deliverability. Considering the results comprehensively, contrast (d = 1) and variance (d = 1) generally showed considerable correlations with every type of plan deliverability. These textural features always showed higher correlations to the plan deliverability than did the conventional modulation indices, except in the case of modulating parameter differences. The rs values of contrast to the global gamma passing rates with criteria of 2%/2 mm, 2%/1 mm, and 1%/2 mm were 0.536, 0.473, and 0.718, respectively. The respective values for variance were 0.551, 0.481, and 0.688. In the case of local gamma passing rates, the rs values of contrast were 0.547, 0.578, and 0.620, respectively, and those of variance were 0.519, 0.527, and 0.569. All of the rs values in those cases were statistically significant (p < 0.003). In the cases of global and local gamma passing rates, MISPORT showed the highest correlations among the conventional modulation indices. For global passing rates, rs values of MISPORT were -0.420, -0.330, and -0.632, respectively, and those for local passing rates were -0.455, -0.490 and -0.502. The values of rs of contrast, variance, and MISPORT with the MLC errors were -0.863, -0.828, and 0.795, respectively, all with statistical significances (p < 0.001). The correlations with statistical significances between variance and dose-volumetric differences were observed more frequently than the others. The contrast (d = 1) and variance (d = 1) calculated from fluence maps of VMAT plans showed considerable correlations with the plan deliverability, indicating their potential use as indicators for assessing the degree of modulation of VMAT plans. Both contrast and variance consistently showed better performance than the conventional modulation indices for VMAT.

Mitigate the impact of transmitter finite extinction ratio using K-means clustering algorithm for 16QAM signal

NASA Astrophysics Data System (ADS)

Yu, Miao; Li, Yan; Shu, Tong; Zhang, Yifan; Hong, Xiaobin; Qiu, Jifang; Zuo, Yong; Guo, Hongxiang; Li, Wei; Wu, Jian

2018-02-01

A method of recognizing 16QAM signal based on k-means clustering algorithm is proposed to mitigate the impact of transmitter finite extinction ratio. There are pilot symbols with 0.39% overhead assigned to be regarded as initial centroids of k-means clustering algorithm. Simulation result in 10 GBaud 16QAM system shows that the proposed method obtains higher precision of identification compared with traditional decision method for finite ER and IQ mismatch. Specially, the proposed method improves the required OSNR by 5.5 dB, 4.5 dB, 4 dB and 3 dB at FEC limit with ER= 12 dB, 16 dB, 20 dB and 24 dB, respectively, and the acceptable bias error and IQ mismatch range is widened by 767% and 360% with ER =16 dB, respectively.

Panoramic imaging and virtual reality — filling the gaps between the lines

NASA Astrophysics Data System (ADS)

Chapman, David; Deacon, Andrew

Close range photogrammetry projects rely upon a clear and unambiguous specification of end-user requirements to inform decisions relating to the format, coverage, accuracy and complexity of the final deliverable. Invariably such deliverables will be a partial and incomplete abstraction of the real world where the benefits of higher accuracy and increased complexity must be traded against the cost of the project. As photogrammetric technologies move into the digital era, computerisation offers opportunities for the photogrammetrist to revisit established mapping traditions in order to explore new markets. One such market is that for three-dimensional Virtual Reality (VR) models for clients who have previously had little exposure to the capabilities, and limitations, of photogrammetry and may have radically different views on the cost/benefit trade-offs in producing geometric models. This paper will present some examples of the authors' recent experience of such markets, drawn from a number of research and commercial projects directed towards the modelling of complex man-made objects. This experience seems to indicate that suitably configured digital image archives may form an important deliverable for a wide range of photogrammetric projects and supplement, or even replace, more traditional CAD models.

The Use of Statistical Measures to Validate System Dynamics Models

DTIC Science & Technology

1992-03-01

C15: (T) [W15] +[FORMMSE]CI4 D15: (T) [W12] +B15-$B$19 E15: (T) +C15-$C$19 F15: (T) (W30] +D15*E15 A16: (T) [W15] +[FORMMSE]AI5 B16 : (T) (W331...FORMMSE]BI5 C16: (T) [W151 +[FORMMSE]C15 D16: (T) [W121 + B16 -$B$19 E16: (T) +C16-$C$19 46 F16: (T) [W30] +D16*El6 A17: (T) [W15] +[FORMMSE]A16 F17: (T...W30] @SUM(F7. .F16) A19: (T) CW151 "Mean= B19: (T) [W331 @AVG(B7. . Bl6 ) C19: (T) [W153 QAVG(C7. .C16) E19: (T) 11r= F19: (T) [W30] ((1/A17)*(F17))/((B20

Managing with A/E Ease

DTIC Science & Technology

1988-07-01

16. Construction Fixes ($K). ([ a16(s) [ bl6 (s)] [ d16(s) 17. Final Actions on Pursuit Cases. ([ a17(s) ]) [bl7(s)] [ d17(s) 18. Carry Over to Next...Construction Fixes ($K). ( [al6 ]) [ b16 ] [d16 17. Final Actions on Pursuit Cases. ( [a17 ]) [b17 ] [d17 18. Carry Over to Next Quarter. [b18 ] [d18 .else

Formation and Assessment of a Tool to Evaluate STEM Literacy in Service-Learning Projects

ERIC Educational Resources Information Center

Hayford, Barbara; Blomstrom, Sally; Mumpower, Lori

2015-01-01

The purpose of the authors' research was to create a tool to evaluate science, technology, engineering, and mathematics (STEM) literacy in service-learning projects. The researchers posited that components of service-learning, which in this case included the deliverable and reflections, are examples of fundamental STEM literacy and thus can be…

ID16B: a hard X-ray nanoprobe beamline at the ESRF for nano-analysis

PubMed Central

Martínez-Criado, Gema; Villanova, Julie; Tucoulou, Rémi; Salomon, Damien; Suuronen, Jussi-Petteri; Labouré, Sylvain; Guilloud, Cyril; Valls, Valentin; Barrett, Raymond; Gagliardini, Eric; Dabin, Yves; Baker, Robert; Bohic, Sylvain; Cohen, Cédric; Morse, John

2016-01-01

Within the framework of the ESRF Phase I Upgrade Programme, a new state-of-the-art synchrotron beamline ID16B has been recently developed for hard X-ray nano-analysis. The construction of ID16B was driven by research areas with major scientific and societal impact such as nanotechnology, earth and environmental sciences, and bio-medical research. Based on a canted undulator source, this long beamline provides hard X-ray nanobeams optimized mainly for spectroscopic applications, including the combination of X-ray fluorescence, X-ray diffraction, X-ray excited optical luminescence, X-ray absorption spectroscopy and 2D/3D X-ray imaging techniques. Its end-station re-uses part of the apparatus of the earlier ID22 beamline, while improving and enlarging the spectroscopic capabilities: for example, the experimental arrangement offers improved lateral spatial resolution (∼50 nm), a larger and more flexible capability for in situ experiments, and monochromatic nanobeams tunable over a wider energy range which now includes the hard X-ray regime (5–70 keV). This paper describes the characteristics of this new facility, short-term technical developments and the first scientific results. PMID:26698084

Texture analysis on the fluence map to evaluate the degree of modulation for volumetric modulated arc therapy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Park, So-Yeon; Institute of Radiation Medicine, Seoul National University Medical Research Center, Seoul 110-744; Biomedical Research Institute, Seoul National University College of Medicine, Seoul 110-744

Purpose: Texture analysis on fluence maps was performed to evaluate the degree of modulation for volumetric modulated arc therapy (VMAT) plans. Methods: A total of six textural features including angular second moment, inverse difference moment, contrast, variance, correlation, and entropy were calculated for fluence maps generated from 20 prostate and 20 head and neck VMAT plans. For each of the textural features, particular displacement distances (d) of 1, 5, and 10 were adopted. To investigate the deliverability of each VMAT plan, gamma passing rates of pretreatment quality assurance, and differences in modulating parameters such as multileaf collimator (MLC) positions, gantrymore » angles, and monitor units at each control point between VMAT plans and dynamic log files registered by the Linac control system during delivery were acquired. Furthermore, differences between the original VMAT plan and the plan reconstructed from the dynamic log files were also investigated. To test the performance of the textural features as indicators for the modulation degree of VMAT plans, Spearman’s rank correlation coefficients (r{sub s}) with the plan deliverability were calculated. For comparison purposes, conventional modulation indices for VMAT including the modulation complexity score for VMAT, leaf travel modulation complexity score, and modulation index supporting station parameter optimized radiation therapy (MI{sub SPORT}) were calculated, and their correlations were analyzed in the same way. Results: There was no particular textural feature which always showed superior correlations with every type of plan deliverability. Considering the results comprehensively, contrast (d = 1) and variance (d = 1) generally showed considerable correlations with every type of plan deliverability. These textural features always showed higher correlations to the plan deliverability than did the conventional modulation indices, except in the case of modulating parameter differences. The r{sub s} values of contrast to the global gamma passing rates with criteria of 2%/2 mm, 2%/1 mm, and 1%/2 mm were 0.536, 0.473, and 0.718, respectively. The respective values for variance were 0.551, 0.481, and 0.688. In the case of local gamma passing rates, the r{sub s} values of contrast were 0.547, 0.578, and 0.620, respectively, and those of variance were 0.519, 0.527, and 0.569. All of the r{sub s} values in those cases were statistically significant (p < 0.003). In the cases of global and local gamma passing rates, MI{sub SPORT} showed the highest correlations among the conventional modulation indices. For global passing rates, r{sub s} values of MI{sub SPORT} were −0.420, −0.330, and −0.632, respectively, and those for local passing rates were −0.455, −0.490 and −0.502. The values of r{sub s} of contrast, variance, and MI{sub SPORT} with the MLC errors were −0.863, −0.828, and 0.795, respectively, all with statistical significances (p < 0.001). The correlations with statistical significances between variance and dose-volumetric differences were observed more frequently than the others. Conclusions: The contrast (d = 1) and variance (d = 1) calculated from fluence maps of VMAT plans showed considerable correlations with the plan deliverability, indicating their potential use as indicators for assessing the degree of modulation of VMAT plans. Both contrast and variance consistently showed better performance than the conventional modulation indices for VMAT.« less

Army Synthetic Validity Project Report of Phase 2 Results. Volume 3. Research Instruments

DTIC Science & Technology

1990-10-01

Areas 7. The type of secondary arms room lock shown at A in the diagram below requires rotation A. monthly B. quarterly C. semiannually D. annually E...building concrete, stone, or other structures (for example, roads, fortifications , buildings, etc.). 16. Operate wheeled vehicles - drive wheeled...for cover and concealment and to place weapons, fortifications , mines, and detectors. 64. Translate foreign languages - translate written or spoken

77 FR 62121 - Guides for the Use of Environmental Marketing Claims

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-11

... example in the Source Reduction section (16 CFR 260.17, Example 1) and retains the guidance on Refillable... marketers can substantiate all reasonable interpretations of these claims.'' \\5\\ A new example illustrates... CFR 260.4(b). \\6\\ 16 CFR 260.4, Example 3. The Commission has moved many of the original examples to...

Delivering bad news in emergency care medicine.

PubMed

Maynard, Douglas W

2017-01-01

Forecasting is a strategy for delivering bad news and is compared to two other strategies, stalling and being blunt. Forecasting provides some warning that bad news is forthcoming without keeping the recipient in a state of indefinite suspense (stalling) or conveying the news abruptly (being blunt). Forecasting appears to be more effective than stalling or being blunt in helping a recipient to "realize" the bad news because it involves the deliverer and recipient in a particular social relation. The deliverer of bad news initiates the telling by giving an advance indication of the bad news to come; this allows the recipient to calculate the news in advance of its final presentation, when the deliverer confirms what the recipient has been led to anticipate. Thus, realization of bad news emerges from intimate collaboration, whereas stalling and being blunt require recipients to apprehend the news in a social vacuum. Exacerbating disruption to recipients' everyday world, stalling and being blunt increase the probability of misapprehension (denying, blaming, taking the situation as a joke, etc.) and thereby inhibit rather than facilitate realization. Particular attention is paid to the "perspective display sequence", a particular forecasting strategy that enables both confirming the recipient's perspective and using that perspective to affirm the clinical news. An example from acute or emergency medicine is examined at the close of the paper.

Improving UXS Network Availability with Asymmetric Polarized MIMO

DTIC Science & Technology

2013-06-01

physical area PA of the antenna by the efficiency of the aperture ( 0 1ap  ) as given by 2 4 ap PG A    . (16) For example, uniformly...2/3 48 -66 5 16-QAM 3/ 4 36 -70 4 16-QAM 1/2 24 -74 3 QPSK 3/ 4 18 -77 2 QPSK 1/2 12 -79 1 BPSK 3/ 4 9 -81 0 BPSK 1/2 6 -82 The standard only...used with the downlink receiver with 2 inputs ( 2 2 ) or 4 inputs ( 2 2p ). For the 2 2 configuration, the 3 dB power loss when 0 5.  is a

New bomb, no mission

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mello, G.

1997-05-01

The cold war may be over, but the nuclear arms race has not quite ended. The United States is fielding a new nuclear weapon-a bomb that was used to threaten Libya, a non-nuclear nation, even before it was deployed. The B61 {open_quotes}mod-11{close_quotes} gravity bomb is the first nuclear capability added to the US arsenal since 1989. It was developed and deployed secretly, without public or congressional debate, and in apparent contradiction to official domestic and international assurances that no new nuclear weapons were being developed in the United States. The B61-11`s unique earth-penetrating characteristic and wide range of yields allowmore » it to threaten otherwide indestructible targets from the air-or, in Pentagonese, to hold such targets {open_quotes}at risk.{close_quotes} That makes the B61-11 a uniquely useful warfighting tool. The 1,200-pound B61-11 replaces the B53, a 8,900-pound, nine-megaton bomb that was developed as a {open_quotes}city buster{close_quotes} and was later designated as a substitute for an earth-penetrating weapon. The B53 was deliverable only by vulnerable B-52s; in contrast, the smaller and lighter B61-11 can be delivered the the stealthier B-2A bomber, or even by F16 fighters.« less

[The effects of infrasound on the blood coagulation function of guinea pigs].

PubMed

Ma, Wen-min; Qi, Peng; Zhang, Jian-zhong; Yi, Yong; Chen, Xing-ming; Zhang, Jun; Han, Rui-gang

2011-03-01

To study the change of the blood coagulation function of guinea pigs exposed to 16 Hz/120 dB, 16 Hz/125 dB infrasound and to explore the mechanism of circulation system damage. Seventy-two guinea pigs were divided into 3 groups: the control group, the group exposed to 16 Hz/120 dB infrasound for 1.5 h a day and the group exposed to 16 Hz/125 dB infrasound for 1.5 h a day. Each exposure group was divided into 4 sub-groups (8 guinea pigs a sub-group) which were exposed to infrasound for 1, 7, 14 and 21 d, respectively. The coagulation function and serum nitric oxide (NO) were measured for control group and all sub-groups after exposure to infrasound. The prothrombin time (PT), international normalized ratio (INR) and serum NO of group exposed to 16 Hz/125 dB infrasound were (31.16 ± 3.05) s, 2.53 ± 1.21 and (88.304 ± 52.601) µmol/L, respectively, which were significantly higher than those [(21.36 ± 0.10) s, 1.65 ± 0.07 and (30.943 ± 26.864) µmol/L] of control group (P < 0.05). PT and INR of sub-groups exposed to 16 Hz/125 dB infrasound for 14 and 21 d were significantly higher than those of control group. NO of sub-groups exposed to 16 Hz/125 dB infrasound for 1 week and 2 weeks were significantly higher than that of control group (P < 0.05), but NO of sub-group exposed to 16 Hz/125 dB infrasound for 3 weeks decreased slightly. The blood coagulation function of guinea pigs exposed to 16 Hz/125 dB infrasound decreased, PT and INR may be used as the indexes to assess of blood coagulation function change induced by the infrasound exposure.

Strategies for improving transportation project delivery performance.

DOT National Transportation Integrated Search

2016-09-01

project delivery performance for the various contracting methods that are : applicable for CTDOTs use. The report is structured in two parts. Part A covers overall : project deliverability and Part B is focused on environmental review processes an...

20 CFR 638.801 - Staff training.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 20 Employees' Benefits 3 2012-04-01 2012-04-01 false Staff training. 638.801 Section 638.801... TITLE IV-B OF THE JOB TRAINING PARTNERSHIP ACT Administrative Provisions § 638.801 Staff training. The... office, and deliverer staff. ...

20 CFR 638.801 - Staff training.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 20 Employees' Benefits 3 2011-04-01 2011-04-01 false Staff training. 638.801 Section 638.801... TITLE IV-B OF THE JOB TRAINING PARTNERSHIP ACT Administrative Provisions § 638.801 Staff training. The... office, and deliverer staff. ...

20 CFR 638.801 - Staff training.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Staff training. 638.801 Section 638.801... TITLE IV-B OF THE JOB TRAINING PARTNERSHIP ACT Administrative Provisions § 638.801 Staff training. The... office, and deliverer staff. ...

The Role of Cyclin D1 in the Chemoresistance of Mantle Cell Lymphoma

DTIC Science & Technology

2017-09-01

Genetic and molecular pathogenesis of mantle cell lymphoma: perspectives for new targeted therapeutics. Nat Rev Cancer. 2007; 7:750–762. 16. Perez...understand the molecular mechanism underlying the resistant nature of mantle cell lymphoma (MCL), an aggressive and incurable B-cell malignancy that is...sufficient and additional genetic lesions are required for MCL development. For example, the Emu-CCND1 transgenic mouse, which mimics the t(11;14

Test Methods for Telemetry Systems and Subsystems. Volume 2: Test Methods for Telemetry Radio Frequency (RF) Subsystems

DTIC Science & Technology

2012-09-01

downconverters; telemetry RF preamplifiers; telemetry multicouplers; telemetry receivers 16. SECURITY CLASSIFICATION OF: 17. LIMITATION OF ABSTRACT Same as...Continuing Engineering Education Program, George Washington University , 1994. A-5 Figure A-2. Graphical representation of intercept point...NFdb) is expressed in decibels and noise factor (nf ) in decimal units. For example, a noise figure of 3 dB corresponds to a noise factor of 2

Catalyzed D-D stellarator reactor

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sheffield, John; Spong, Donald A.

The advantages of using the catalyzed deuterium-deuterium (D-D) approach for a fusion reactor—lower and less energetic neutron flux and no need for a tritium breeding blanket—have been evaluated in previous papers, giving examples of both tokamak and stellarator reactors. This paper presents an update for the stellarator example, taking account of more recent empirical transport scaling results and design studies of lower-aspect-ratio stellarators. We use a modified version of the Generic Magnetic Fusion Reactor model to cost a stellarator-type reactor. Recently, this model has been updated to reflect the improved science and technology base and costs in the magnetic fusionmore » program. Furthermore, it is shown that an interesting catalyzed D-D, stellarator power plant might be possible if the following parameters could be achieved: R/ ≈ 4, required improvement factor to ISS04 scaling, F R = 0.9 to 1.15, ≈ 8.0% to 11.5%, Z eff ≈ 1.45 plus a relativistic temperature correction, fraction of fast ions lost ≈ 0.07, B m ≈ 14 to 16 T, and R ≈ 18 to 24 m.« less

Catalyzed D-D stellarator reactor

DOE PAGES

Sheffield, John; Spong, Donald A.

2016-05-12

The advantages of using the catalyzed deuterium-deuterium (D-D) approach for a fusion reactor—lower and less energetic neutron flux and no need for a tritium breeding blanket—have been evaluated in previous papers, giving examples of both tokamak and stellarator reactors. This paper presents an update for the stellarator example, taking account of more recent empirical transport scaling results and design studies of lower-aspect-ratio stellarators. We use a modified version of the Generic Magnetic Fusion Reactor model to cost a stellarator-type reactor. Recently, this model has been updated to reflect the improved science and technology base and costs in the magnetic fusionmore » program. Furthermore, it is shown that an interesting catalyzed D-D, stellarator power plant might be possible if the following parameters could be achieved: R/ ≈ 4, required improvement factor to ISS04 scaling, F R = 0.9 to 1.15, ≈ 8.0% to 11.5%, Z eff ≈ 1.45 plus a relativistic temperature correction, fraction of fast ions lost ≈ 0.07, B m ≈ 14 to 16 T, and R ≈ 18 to 24 m.« less

Multidimensional correlation among plan complexity, quality and deliverability parameters for volumetric-modulated arc therapy using canonical correlation analysis.

PubMed

Shen, Lanxiao; Chen, Shan; Zhu, Xiaoyang; Han, Ce; Zheng, Xiaomin; Deng, Zhenxiang; Zhou, Yongqiang; Gong, Changfei; Xie, Congying; Jin, Xiance

2018-03-01

A multidimensional exploratory statistical method, canonical correlation analysis (CCA), was applied to evaluate the impact of complexity parameters on the plan quality and deliverability of volumetric-modulated arc therapy (VMAT) and to determine parameters in the generation of an ideal VMAT plan. Canonical correlations among complexity, quality and deliverability parameters of VMAT, as well as the contribution weights of different parameters were investigated with 71 two-arc VMAT nasopharyngeal cancer (NPC) patients, and further verified with 28 one-arc VMAT prostate cancer patients. The average MU and MU per control point (MU/CP) for two-arc VMAT plans were 702.6 ± 55.7 and 3.9 ± 0.3 versus 504.6 ± 99.2 and 5.6 ± 1.1 for one-arc VMAT plans, respectively. The individual volume-based 3D gamma passing rates of clinical target volume (γCTV) and planning target volume (γPTV) for NPC and prostate cancer patients were 85.7% ± 9.0% vs 92.6% ± 7.8%, and 88.0% ± 7.6% vs 91.2% ± 7.7%, respectively. Plan complexity parameters of NPC patients were correlated with plan quality (P = 0.047) and individual volume-based 3D gamma indices γ(IV) (P = 0.01), in which, MU/CP and segment area (SA) per control point (SA/CP) were weighted highly in correlation with γ(IV) , and SA/CP, percentage of CPs with SA < 5 × 5 cm2 (%SA < 5 × 5 cm2) and PTV volume were weighted highly in correlation with plan quality with coefficients of 0.98, 0.68 and -0.99, respectively. Further verification with one-arc VMAT plans demonstrated similar results. In conclusion, MU, SA-related parameters and PTV volume were found to have strong effects on the plan quality and deliverability.

Multidimensional correlation among plan complexity, quality and deliverability parameters for volumetric-modulated arc therapy using canonical correlation analysis

PubMed Central

Shen, Lanxiao; Chen, Shan; Zhu, Xiaoyang; Han, Ce; Zheng, Xiaomin; Deng, Zhenxiang; Zhou, Yongqiang; Gong, Changfei; Jin, Xiance

2018-01-01

Abstract A multidimensional exploratory statistical method, canonical correlation analysis (CCA), was applied to evaluate the impact of complexity parameters on the plan quality and deliverability of volumetric-modulated arc therapy (VMAT) and to determine parameters in the generation of an ideal VMAT plan. Canonical correlations among complexity, quality and deliverability parameters of VMAT, as well as the contribution weights of different parameters were investigated with 71 two-arc VMAT nasopharyngeal cancer (NPC) patients, and further verified with 28 one-arc VMAT prostate cancer patients. The average MU and MU per control point (MU/CP) for two-arc VMAT plans were 702.6 ± 55.7 and 3.9 ± 0.3 versus 504.6 ± 99.2 and 5.6 ± 1.1 for one-arc VMAT plans, respectively. The individual volume-based 3D gamma passing rates of clinical target volume (γCTV) and planning target volume (γPTV) for NPC and prostate cancer patients were 85.7% ± 9.0% vs 92.6% ± 7.8%, and 88.0% ± 7.6% vs 91.2% ± 7.7%, respectively. Plan complexity parameters of NPC patients were correlated with plan quality (P = 0.047) and individual volume-based 3D gamma indices γ(IV) (P = 0.01), in which, MU/CP and segment area (SA) per control point (SA/CP) were weighted highly in correlation with γ(IV) , and SA/CP, percentage of CPs with SA < 5 × 5 cm2 (%SA < 5 × 5 cm2) and PTV volume were weighted highly in correlation with plan quality with coefficients of 0.98, 0.68 and −0.99, respectively. Further verification with one-arc VMAT plans demonstrated similar results. In conclusion, MU, SA-related parameters and PTV volume were found to have strong effects on the plan quality and deliverability. PMID:29415196

Multi-Agent System for Recruiting Patients for Clinical Trials

DTIC Science & Technology

2014-05-01

between agents, i.e. the flow of information. To provide greater insight, the links are also anno - tated with example operations that occur through these...then to achieve a full system evaluation that explores the intricacies of the agents in in wild. 8. REFERENCES [1] L. B. Afrin, J . C. Oates, C. K...2003:16–20. [2] A. J . Butte, D. A. Weinstein, and I. S. Kohane. Enrolling patients into clinical trials faster using realtime recuiting. Proceedings

VHDL Simulation of the Implementation of a Costfunction Circuit.

DTIC Science & Technology

1990-09-01

the characteristic delays for each component. At this point in time, it is not necessary for the VHDL code to implement the exact hardware...NAVAL POSTGRADUATE SCHOOL Monterey, California AD-A240 430 ,DSTATv, OTIC"b El FCTE 9% SEP 16 1991 ru m D THESIS VHDL Simulation of the Implementation ...partition algorithm is used here as an example to test the VHDL design methodology. Subroutines or statements in the software can be implemented into

47 CFR 80.205 - Bandwidths.

Code of Federal Regulations, 2010 CFR

2010-10-01

... frequency deviation for F3E or G3E emission is as follows: (1) 5 kHz in the 72.0-73.0 MHz, 75.4-76.0 MHz and... 12 16K0A2D 20.0 A3E 6K00A3E 8.0 A3N 2 2K66A3N 2.8 A3X 3 3K20A3X 25.0 F1B 4 280HF1B 0.3 F1B 5 300HF1B 0.5 F1B 6 16KOF1B 20.0 F1C 2K80F1C 3.0 F1D 12 16K0F1D 20.0 F2B 6 16KOF2B 20.0 F2C 7 16KOF2C 20.0 F2D...

The NASA Electronic Parts and Packaging (NEPP) Program - Presentation to Korean Aerospace Research Institute

NASA Technical Reports Server (NTRS)

LaBel, Kenneth A.; Sampson, Michael J.

2016-01-01

This presentation will provide basic information about NASA's Electronic Parts and Packaging Program (NEPP), for sharing with representatives of the South Korean Aerospace Research Institute (KARI) as part of a larger presentation by Headquarters Office of Safety and Mission Assurance. The NEPP information includes mission and goals, history of the program, basic focus areas, strategies, deliverables and some examples of current tasks.

THz Sources for Space

NASA Technical Reports Server (NTRS)

Siegel, Peter H.; Ward, John; Maiwald, Frank; Mehdi, Imran

2007-01-01

Terahertz is the primary frequency for line and continuum radiation from cool (5-100K) gas (atoms and molecules) and dust. This viewgraph presentation reviews the reasons for the interest in Terahertz Space Applications; the Terahertz Space Missions: in the past, present and planned for the future, Terahertz source requirements and examples of some JPL instruments; and a case study for a flight deliverable: THz Local Oscillators for ESA s Herschel Space Telescope

Deliverance from the "Dark Night of the Soul"

ERIC Educational Resources Information Center

Kinnier, Richard T.; Dixon, Andrea L.; Scheidegger, Corey; Lindberg, Brent

2009-01-01

For many individuals, spiritual inspiration, clarity, or epiphany is often preceded by a "dark night of the soul". St. John of the Cross, a Spanish mystic of the 16th century, first described the concept. Today, the phrase "dark night of the soul" is usually associated with the crisis part of the journey to enlightenment. This article defines and…

Systems implications of L-band fade data statistics for LEO mobile systems

NASA Technical Reports Server (NTRS)

Devieux, Carrie L.

1993-01-01

This paper examines and analyzes research data on the role of foliage attenuation in signal fading between a satellite transmitter and a terrestrial vehicle-mounted receiver. The frequency band of measurement, called L-Band, includes the region 1610.0 to 1626.5 MHz. Data from tests involving various combinations of foliage and vehicle movement conditions clearly show evidence of fast fading (in excess of 0.5 dB per millisecond) and fade depths as great or greater than 16 dB. As a result, the design of a communications link power control that provides the level of accuracy necessary for power sensitive systems could be significantly impacted. Specific examples of this include the communications links that employ Code Division Multiple Access (CDMA) as a modulation technique.

Systems implications of L-band fade data statistics for LEO mobile systems

NASA Astrophysics Data System (ADS)

Devieux, Carrie L.

This paper examines and analyzes research data on the role of foliage attenuation in signal fading between a satellite transmitter and a terrestrial vehicle-mounted receiver. The frequency band of measurement, called L-Band, includes the region 1610.0 to 1626.5 MHz. Data from tests involving various combinations of foliage and vehicle movement conditions clearly show evidence of fast fading (in excess of 0.5 dB per millisecond) and fade depths as great or greater than 16 dB. As a result, the design of a communications link power control that provides the level of accuracy necessary for power sensitive systems could be significantly impacted. Specific examples of this include the communications links that employ Code Division Multiple Access (CDMA) as a modulation technique.

[Effects of infrasound on visual electrophysiology in mice].

PubMed

Shi, Li; Zhang, Zuo-ming; Chen, Jing-zao; Liu, Jing

2003-04-01

To investigate the possible effects of infrasound on visual functions. One hundred and fifty mature male Kunming-mice were divided into 5 groups, in which one was control and the other four were exposed to infrasound of 8 Hz, 90 dB; 8 Hz, 130 dB; 16 Hz, 90 dB and 16 Hz, 130 dB 2 h/d respectively. The exposure time for them were 0, 1, 4, 7, 14 and 21 d respectively, each group was divided into 6 sub-groups. Electroretinogram (ERG), oscillatory potentials (OPs), and visual evoked potential (VEP) were recorded after exposure. The visual electrophysiological indices after 8 Hz, 90 dB and 16 Hz, 90 dB exposures were similar except for a little difference at some temporal points (P<0.05). Most of the indices in 8 Hz, 130 dB group changed after 7 d exposure, and the longer the exposure, the more obvious changes were observed (P<0.01). The indices in 16 Hz, 130 dB group changed obviously after 1 d and reversed with increase of exposure time (P<0.01). The effect of infrasound on visual functions are related to its frequency and intensity. Infrasound of different frequencies causes different levels of retinal resonance, which leads to different degrees of cellular lesion and produces different electrical potentials.

Establishing Criteria for Assigning Personnel to Air Force Jobs Requiring Heavy Work

DTIC Science & Technology

1978-07-01

loads (for example, carrying meat at the slaughterhouse , carrying of sacks, loading wood by hand) wood cutting in the forest by hand tools, agricultural...8217 factor history. Medical Service Digest (United States Air Force), 27(2), 1976, pp. 14-16. 186 Trimeloni, Col. B.D. The Role of Women in the Air Force...Rahden. Effect of training on maximum oxygen intake and on anaerobic metabolism in man. Int. Z. Angew Physiol., 24(2), 1967, pp. 102-110. 188 Wyndham, C.H

System Engineering Processes at Kennedy Space Center for Development of the SLS and Orion Launch Systems

NASA Technical Reports Server (NTRS)

Schafer, Eric J.

2012-01-01

There are over 40 subsystems being developed for the future SLS and Orion Launch Systems at Kennedy Space Center. These subsystems developed at the Kennedy Space Center Engineering Directorate follow a comprehensive design process which requires several different product deliverables during each phase of each of the subsystems. This Paper describes this process and gives an example of where the process has been applied.

48 CFR 2011.104-70 - NRC Clauses.

Code of Federal Regulations, 2014 CFR

2014-10-01

... Technical Reports, when deliverables include a technical report. (b) The contracting officer shall insert the clause at 2052.211-71 Technical Progress Report, in all solicitations and contracts except— (1...) The contracting officer shall insert the clause at 2052.211-72 Financial Status Report, in applicable...

48 CFR 2011.104-70 - NRC Clauses.

Code of Federal Regulations, 2013 CFR

2013-10-01

... Technical Reports, when deliverables include a technical report. (b) The contracting officer shall insert the clause at 2052.211-71 Technical Progress Report, in all solicitations and contracts except— (1...) The contracting officer shall insert the clause at 2052.211-72 Financial Status Report, in applicable...

48 CFR 2011.104-70 - NRC Clauses.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Technical Reports, when deliverables include a technical report. (b) The contracting officer shall insert the clause at 2052.211-71 Technical Progress Report, in all solicitations and contracts except— (1...) The contracting officer shall insert the clause at 2052.211-72 Financial Status Report, in applicable...

48 CFR 2011.104-70 - NRC Clauses.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Technical Reports, when deliverables include a technical report. (b) The contracting officer shall insert the clause at 2052.211-71 Technical Progress Report, in all solicitations and contracts except— (1...) The contracting officer shall insert the clause at 2052.211-72 Financial Status Report, in applicable...

48 CFR 2011.104-70 - NRC Clauses.

Code of Federal Regulations, 2012 CFR

2012-10-01

... Technical Reports, when deliverables include a technical report. (b) The contracting officer shall insert the clause at 2052.211-71 Technical Progress Report, in all solicitations and contracts except— (1...) The contracting officer shall insert the clause at 2052.211-72 Financial Status Report, in applicable...

20 CFR 638.539 - Complaints and disputes.

Code of Federal Regulations, 2010 CFR

2010-04-01

....539 Employees' Benefits EMPLOYMENT AND TRAINING ADMINISTRATION, DEPARTMENT OF LABOR JOB CORPS PROGRAM UNDER TITLE IV-B OF THE JOB TRAINING PARTNERSHIP ACT Center Operations § 638.539 Complaints and disputes. (a) Center and other deliverer grievance procedures. Each center operator or other Job Corps...

Project deliverables - a waste of time or a chance for knowledge transfer and dissemination?

NASA Astrophysics Data System (ADS)

Walter, Sylvia

2016-04-01

Deliverables are a common tool to measure a distinct output of a project. They should be meaningful in terms of the project's objectives and are normally constituted by e.g. a written report or document, a developed tool or software, an organized training or conference. They can be scientific or technical. The number of deliverables must be reasonable and commensurate to the project and its content. Deliverables as contractual obligations are often time consuming and often seen as a waste of "research" time, as one more administrative task without any use. However, deliverables are needed to verify the progress of a project and to convince the sponsor that the project is going in the right direction and the money well-invested. The presentation will deal with the question on how to use a deliverable in a profitable way for the project and what are the possibilities of use.

Mechanical Properties of AM Stainless Steel Parts and Repair Welds

DOE Office of Scientific and Technical Information (OSTI.GOV)

Vogel, Sven C.; Carpenter, John S.

2015-02-22

Goals: Advance certification of AM materials and compare microstructure and its evolution during processing and deformation between AM fabricated and conventional steels. Deliverables achieved: Measured texture data for 17 steel samples on HIPPO, including material planned to be shocked in pRAD in FY16; quantified texture and austenite/ferrite phase fractions; and provide input data for deformation modeling.

Extensible Adaptive System for STEM Learning

DTIC Science & Technology

2013-07-16

Copyright 2013 Raytheon BBN Technologies Corp. All Rights Reserved ONR STEM Grand Challenge Extensible Adaptive System for STEM Learning ...Contract # N00014-12-C-0535 Raytheon BBN Technologies Corp. (BBN) Reference # 14217 In partial fulfillment of contract deliverable item # A001...Quarterly Progress Report #2 April 7, 2013 –July 6, 2013 Submitted July 16, 2013 BBN Technical POC: John Makhoul Raytheon BBN Technologies

Effect on LTAS of vocal loudness variation.

PubMed

Nordenberg, Maria; Sundberg, Johan

2004-01-01

Long-term-average spectrum (LTAS) is an efficient method for voice analysis, revealing both voice source and formant characteristics. However, the LTAS contour is non-uniformly affected by vocal loudness. This variation was analyzed in 15 male and 16 female untrained voices reading a text 7 times at different degrees of vocal loudness, mean change in overall equivalent sound level (Leq) amounting to 27.9 dB and 28.4 dB for the female and male subjects. For all frequency values up to 4 kHz, spectrum level was strongly and linearly correlated with Leq for each subject. The gain factor, that is to say, the rate of level increase, varied with frequency, from about 0.5 at low frequencies to about 1.5 in the frequency range 1.5-3 kHz. Using the gain factors for a subject, LTAS contours could be predicted at any Leq within the measured range, with an average accuracy of 2-3 dB below 4 kHz. Mean LTAS calculated for an Leq of 70 dB for each subject showed considerable individual variation for both males and females, SD of the level varying between 7 dB and 4 dB depending on frequency. On the other hand, the results also suggest that meaningful comparisons of LTAS, recorded for example before and after voice therapy, can be made, provided that the documentation includes a set of recordings at different loudness levels from one recording session.

Innovative Techniques for the Production of Low Cost 2D Laser Diode Arrays

DTIC Science & Technology

1991-11-26

electrically isolated and liquid cooled. (Deliverables: 5 5-bar arrays.) The following global issues not mentioned above will be investigated...house facet coating station. All global issues mentioned in Section 2.0 will be addressed and continuously investigated during this program. Very

48 CFR 227.7103-6 - Contract clauses.

Code of Federal Regulations, 2013 CFR

2013-10-01

... private expense). Do not use the clause when the only deliverable items are computer software or computer software documentation (see 227.72), commercial items developed exclusively at private expense (see 227... the clause in architect-engineer and construction contracts. (b)(1) Use the clause at 252.227-7013...

48 CFR 227.7103-6 - Contract clauses.

Code of Federal Regulations, 2014 CFR

2014-10-01

... private expense). Do not use the clause when the only deliverable items are computer software or computer software documentation (see 227.72), commercial items developed exclusively at private expense (see 227... the clause in architect-engineer and construction contracts. (b)(1) Use the clause at 252.227-7013...

Medicinal foodstuffs. XXVII. Saponin constituents of gotu kola (2): structures of new ursane- and oleanane-type triterpene oligoglycosides, centellasaponins B, C, and D, from Centella asiatica cultivated in Sri Lanka.

PubMed

Matsuda, H; Morikawa, T; Ueda, H; Yoshikawa, M

2001-10-01

Ursane- and oleanane-type triterpene oligoglycosides, centellasaponins B, C, and D, were isolated from the aerial parts of Centella asiatica (L.) Urban cultivated in Sri Lanka together with madecassoside, asiaticoside, asiaticoside B, and sceffoleoside A. The chemical structures of centellasaponins B, C, and D were determined on the basis of chemical and physicochemical evidence to be madecassic acid 28-O-beta-D-glucopyranosyl(1-->6)-beta-D-glucopyranoside, madasiatic acid 28-O-alpha-L-rhamnopyranosyl(1-->4)-beta-D-glucopyranosyl(1-->6)-beta-D-glucopyranoside, and 3beta,6beta,23-trihydroxyolean-12-en-28-oic acid 28-O-alpha-L-rhamnopyranosyl(1-->4)-beta-D-glucopyranosyl(1-->6)-beta-D-glucopyranoside, respectively.

PTM Modeling of Dredged Suspended Sediment at Proposed Polaris Point and Ship Repair Facility CVN Berthing Sites - Apra Harbor, Guam

DTIC Science & Technology

2017-09-01

ADCP locations used for model calibration. ......................................................................... 12 Figure 4-3. Sample water...Example of fine sediment sample [Set d, Sample B30]. (B) Example of coarse sediment sample [Set d, sample B05...Turning Basin average sediment size distribution curve. ................................................... 21 Figure 5-5. Turning Basin average size

System Engineering Processes at Kennedy Space Center for Development of SLS and Orion Launch Systems

NASA Technical Reports Server (NTRS)

Schafer, Eric; Stambolian, Damon; Henderson, Gena

2013-01-01

There are over 40 subsystems being developed for the future SLS and Orion Launch Systems at Kennedy Space Center. These subsystems are developed at the Kennedy Space Center Engineering Directorate. The Engineering Directorate at Kennedy Space Center follows a comprehensive design process which requires several different product deliverables during each phase of each of the subsystems. This Presentation describes this process with examples of where the process has been applied.

Evaluating Intellectual Property and Data Rights in Competition Source Selections - Leveraging the Assertions Process to a New Level to Foster Open Systems Architecture

DTIC Science & Technology

2015-04-30

itself. This is the traditional methodology (combined with attaching commercial software licenses to the contract and citing patent royalty ... Royalties It helps to visualize the Intellectual Property Volume approach so the following notional tables with example deliverable technical data...attorney’s fees  Automatic renewal provisions that violate the Anti-Deficiency Act  Provisions that prohibit disclosure of license terms/conditions

OpenMDAO Framework Status

NASA Technical Reports Server (NTRS)

Naiman, Cynthia Gutierrez

2010-01-01

Advancing and exploring the science of Multidisciplinary Analysis & Optimization (MDAO) capabilities are high-level goals in the Fundamental Aeronautics Program s Subsonic Fixed Wing (SFW) project. The OpenMDAO team has made significant progress toward completing the Alpha OpenMDAO deliverable due in September 2010. Included in the presentation are: details of progress on developing the OpenMDAO framework, example usage of OpenMDAO, technology transfer plans, near term plans, progress toward establishing partnerships with external parties, and discussion of additional potential collaborations.

Suppression of HPV-16 late L1 5′-splice site SD3632 by binding of hnRNP D proteins and hnRNP A2/B1 to upstream AUAGUA RNA motifs

PubMed Central

Li, Xiaoze; Johansson, Cecilia; Glahder, Jacob; Mossberg, Ann-Kristin; Schwartz, Stefan

2013-01-01

Human papillomavirus type 16 (HPV-16) 5′-splice site SD3632 is used exclusively to produce late L1 mRNAs. We identified a 34-nt splicing inhibitory element located immediately upstream of HPV-16 late 5′-splice site SD3632. Two AUAGUA motifs located in these 34 nt inhibited SD3632. Two nucleotide substitutions in each of the HPV-16 specific AUAGUA motifs alleviated splicing inhibition and induced late L1 mRNA production from episomal forms of the HPV-16 genome in primary human keratinocytes. The AUAGUA motifs bind specifically not only to the heterogeneous nuclear RNP (hnRNP) D family of RNA-binding proteins including hnRNP D/AUF, hnRNP DL and hnRNP AB but also to hnRNP A2/B1. Knock-down of these proteins induced HPV-16 late L1 mRNA expression, and overexpression of hnRNP A2/B1, hnRNP AB, hnRNP DL and the two hnRNP D isoforms hnRNP D37 and hnRNP D40 further suppressed L1 mRNA expression. This inhibition may allow HPV-16 to hide from the immune system and establish long-term persistent infections with enhanced risk at progressing to cancer. There is an inverse correlation between expression of hnRNP D proteins and hnRNP A2/B1 and HPV-16 L1 production in the cervical epithelium, as well as in cervical cancer, supporting the conclusion that hnRNP D proteins and A2/B1 inhibit HPV-16 L1 mRNA production. PMID:24013563

48 CFR 227.7103-6 - Contract clauses.

Code of Federal Regulations, 2011 CFR

2011-10-01

... expense). Do not use the clause when the only deliverable items are computer software or computer software... architect-engineer and construction contracts. (b)(1) Use the clause at 252.227-7013 with its Alternate I in... Software Previously Delivered to the Government, in solicitations when the resulting contract will require...

48 CFR 227.7103-6 - Contract clauses.

Code of Federal Regulations, 2012 CFR

2012-10-01

... expense). Do not use the clause when the only deliverable items are computer software or computer software... architect-engineer and construction contracts. (b)(1) Use the clause at 252.227-7013 with its Alternate I in... Software Previously Delivered to the Government, in solicitations when the resulting contract will require...

Reference Models for Multi-Layer Tissue Structures

DTIC Science & Technology

2016-09-01

simulation,  finite   element  analysis 16. SECURITY CLASSIFICATION OF: 17. LIMITATION OF ABSTRACT 18. NUMBER OF PAGES 19a. NAME OF RESPONSIBLE PERSON USAMRMC...Physiologically realistic, fully specimen-specific, nonlinear reference models. Tasks. Finite element analysis of non-linear mechanics of cadaver...models. Tasks. Finite element analysis of non-linear mechanics of multi-layer tissue regions of human subjects. Deliverables. Partially subject- and

Experimental investigation of extended Kalman Filter combined with carrier phase recovery for 16-QAM system

NASA Astrophysics Data System (ADS)

Shu, Tong; Li, Yan; Yu, Miao; Zhang, Yifan; Zhou, Honghang; Qiu, Jifang; Guo, Hongxiang; Hong, Xiaobin; Wu, Jian

2018-02-01

Performance of Extended Kalman Filter combined with the Viterbi-Viterbi phase estimation (VVPE-EKF) for joint phase noise mitigation and amplitude noise equalization is experimental demonstrated. Experimental results show that, for 11.2 Gbaud SP-16-QAM, the proposed VVPE-EKF achieves 0.9 dB required OSNR reduction at bit error ratio (BER) of 3.8e-3 compared to the VVPE. The result of maximum likelihood combined with VVPE (VVPE-ML) is only 0.3 dB. For 28 GBaud SP-16-QAM signal, VVPE-EKF achieves 3 dB required OSNR reduction at BER=3.8e-3 (7% HD-FEC threshold) compared to VVPE. And VVPE-ML can reduce the required OSNR for 1.7 dB compared to the VVPE. VVPE-EKF outperforms DD-EKF 3.7 dB and 0.7 dB for 11.2 GBaud and 28 GBaud system, respectively.

49 CFR 22.25 - Lender deliverables and delivery schedule.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 49 Transportation 1 2010-10-01 2010-10-01 false Lender deliverables and delivery schedule. 22.25 Section 22.25 Transportation Office of the Secretary of Transportation SHORT-TERM LENDING PROGRAM (STLP) Participating Lenders § 22.25 Lender deliverables and delivery schedule. All Participating Lenders must adhere...

M5-brane and D-brane scattering amplitudes

NASA Astrophysics Data System (ADS)

Heydeman, Matthew; Schwarz, John H.; Wen, Congkao

2017-12-01

We present tree-level n-particle on-shell scattering amplitudes of various brane theories with 16 conserved supercharges. These include the world-volume theory of a probe D3-brane or D5-brane in 10D Minkowski spacetime as well as a probe M5-brane in 11D Minkowski spacetime, which describes self interactions of an abelian tensor supermultiplet with 6D (2, 0) supersymmetry. Twistor-string-like formulas are proposed for tree-level scattering amplitudes of all multiplicities for each of these theories. The R symmetry of the D3-brane theory is shown to be SU(4) × U(1), and the U(1) factor implies that its amplitudes are helicity conserving. Each of 6D theories (D5-brane and M5-brane) reduces to the D3-brane theory by dimensional reduction. As special cases of the general M5-brane amplitudes, we present compact formulas for examples involving only the self-dual B field with n = 4, 6, 8.

Resonant Inductive Decoupling (RID) for Transceiver Arrays to Compensate for both Reactive and Resistive Components of the Mutual Impedance

PubMed Central

Avdievich, Nikolai I.; Pan, Jullie W.; Hetherington, Hoby P.

2013-01-01

Transceiver surface coil arrays improve transmit performance (B1/√kW) and B1 homogeneity for head imaging up to 9.4 T. To further improve reception performance and parallel imaging the number of array elements has to be increased with correspondent decrease of their size. With a large number of small interacting antennas decoupling is one of the most challenging aspects in the design and construction of transceiver arrays. Previously described decoupling techniques using geometric overlap, inductive or capacitive decoupling have focused on eliminating only the reactance of the mutual impedance, which can limit the obtainable decoupling to −10 dB due to residual mutual resistance. A novel resonant inductive decoupling (RID) method, which allows compensation for both reactive and resistive components of the mutual impedance between the adjacent surface coils, has been developed and experimentally verified. This method provides an easy way to adjust the decoupling remotely by changing the resonance frequency of the RID circuit through adjustment of a variable capacitor. As an example a single row (1×16) 7T transceiver head array of n=16 small overlapped surface coils using RID decoupling between adjacent coils was built. In combination with overlapped coils the RID technique achieved better than −24 dB of decoupling for all adjacent coils. PMID:23775840

26 CFR 1.1374-0 - Table of contents.

Code of Federal Regulations, 2011 CFR

2011-04-01

... general. (b) Allocation rule. (c) Recognized built-in gain carryover. (d) Accounting methods. (e) Example. § 1.1374-3 Net unrealized built-in gain. (a) In general. (b) Example. § 1.1374-4 Recognized built-in gain or loss. (a) Sales and exchanges. (1) In general. (2) Oil and gas property. (3) Examples. (b...

Multi-centre audit of VMAT planning and pre-treatment verification.

PubMed

Jurado-Bruggeman, Diego; Hernández, Victor; Sáez, Jordi; Navarro, David; Pino, Francisco; Martínez, Tatiana; Alayrach, Maria-Elena; Ailleres, Norbert; Melero, Alejandro; Jornet, Núria

2017-08-01

We performed a multi-centre intercomparison of VMAT dose planning and pre-treatment verification. The aims were to analyse the dose plans in terms of dosimetric quality and deliverability, and to validate whether in-house pre-treatment verification results agreed with those of an external audit. The nine participating centres encompassed different machines, equipment, and methodologies. Two mock cases (prostate and head and neck) were planned using one and two arcs. A plan quality index was defined to compare the plans and different complexity indices were calculated to check their deliverability. We compared gamma index pass rates using the centre's equipment and methodology to those of an external audit (global 3D gamma, absolute dose differences, 10% of maximum dose threshold). Log-file analysis was performed to look for delivery errors. All centres fulfilled the dosimetric goals but plan quality and delivery complexity were heterogeneous and uncorrelated, depending on the manufacturer and the planner's methodology. Pre-treatment verifications results were within tolerance in all cases for gamma 3%-3mm evaluation. Nevertheless, differences between the external audit and in-house measurements arose due to different equipment or methodology, especially for 2%-2mm criteria with differences up to 20%. No correlation was found between complexity indices and verification results amongst centres. All plans fulfilled dosimetric constraints, but plan quality and complexity did not correlate and were strongly dependent on the planner and the vendor. In-house measurements cannot completely replace external audits for credentialing. Copyright © 2017 Elsevier B.V. All rights reserved.

Implementing LPC (Linear Predictive Coding) Algorithms in the Study of Speech Processing.

DTIC Science & Technology

1983-12-01

DRAND(IX) DOUBLE PRECISION INTEGER IXAP.B15.B165XHI 5XALO.LEFTLO,FHIK DATA A/1&607D0/. B15/3276BD0/. Bl6 /65536D0/. P/2147483647D0/ XHI - IX/ B16 XHI...XHI -DMOD(XHI, IDO) XALO = (IX- XHI * B16 ) * A LEFTLO -XALO/1116 LEFTLO = LEFTLO - DMOD(LEFTLO. iDO)I FHI -XHI * A + LEFTLO K = FHI/B15 K = K - DMOD(K1...iDO) IX = (((XALO-LEFTL0*916)-P) +- (FHI-K*Bl5)* B16 )+K IF(IX.LT.O.DOe IX= X *FILENAME: GLOTI.FR DATE: 12: 2:83 TIME: 13:45:38 PAGE C C THIS SUBROUTINE

16 CFR 803.9 - Filing fee.

Code of Federal Regulations, 2014 CFR

2014-01-01

... minus $1 million. In this example, since “A” is able in good faith to reasonably estimate the... 16 Commercial Practices 1 2014-01-01 2014-01-01 false Filing fee. 803.9 Section 803.9 Commercial... of the Department of Justice. Examples: 1. “A” wishes to acquire voting securities issued by B, where...

Drosophila Vps16A is required for trafficking to lysosomes and biogenesis of pigment granules.

PubMed

Pulipparacharuvil, Suprabha; Akbar, Mohammed Ali; Ray, Sanchali; Sevrioukov, Evgueny A; Haberman, Adam S; Rohrer, Jack; Krämer, Helmut

2005-08-15

Mutations that disrupt trafficking to lysosomes and lysosome-related organelles cause multiple diseases, including Hermansky-Pudlak syndrome. The Drosophila eye is a model system for analyzing such mutations. The eye-color genes carnation and deep orange encode two subunits of the Vps-C protein complex required for endosomal trafficking and pigment-granule biogenesis. Here we demonstrate that dVps16A (CG8454) encodes another Vps-C subunit. Biochemical experiments revealed a specific interaction between the dVps16A C-terminus and the Sec1/Munc18 homolog Carnation but not its closest homolog, dVps33B. Instead, dVps33B interacted with a related protein, dVps16B (CG18112). Deep orange bound both Vps16 homologs. Like a deep orange null mutation, eye-specific RNAi-induced knockdown of dVps16A inhibited lysosomal delivery of internalized ligands and interfered with biogenesis of pigment granules. Ubiquitous knockdown of dVps16A was lethal. Together, these findings demonstrate that Drosophila Vps16A is essential for lysosomal trafficking. Furthermore, metazoans have two types of Vps-C complexes with non-redundant functions.

Teachers' Views of Inclusion: "I'd Rather Pump Gas."

ERIC Educational Resources Information Center

Vaughn, Sharon; And Others

The issue of inclusion has been at the forefront of attention in education, and has been widely discussed and debated. Since teachers will be the primary service deliverers of whatever inclusion practices are adopted, this study was conducted in an attempt better to understand teachers' understanding and perceptions of inclusion. Focus group…

Characterization of unpaved road condition through the use of remote sensing project - phase II, deliverable 8-D: final report.

DOT National Transportation Integrated Search

2016-03-07

Building on the success of developing a UAV based unpaved road assessment system in Phase I, the project team was awarded a Phase II project by the USDOT to focus on outreach and implementation. The project team added Valerie Lefler of Integrated Glo...

Tailoring porosity and rotational dynamics in a series of octacarboxylate metal-organic frameworks

PubMed Central

Moreau, Florian; Kolokolov, Daniil I.; Stepanov, Alexander G.; Easun, Timothy L.; Dailly, Anne; Blake, Alexander J.; Nowell, Harriott; Lennox, Matthew J.; Yang, Sihai; Schröder, Martin

2017-01-01

Modulation and precise control of porosity of metal-organic frameworks (MOFs) is of critical importance to their materials function. Here we report modulation of porosity for a series of isoreticular octacarboxylate MOFs, denoted MFM-180 to MFM-185, via a strategy of selective elongation of metal-organic cages. Owing to the high ligand connectivity, these MOFs do not show interpenetration, and are robust structures that have permanent porosity. Interestingly, activated MFM-185a shows a high Brunauer–Emmett–Teller (BET) surface area of 4,734 m2 g−1 for an octacarboxylate MOF. These MOFs show remarkable CH4 and CO2 adsorption properties, notably with simultaneously high gravimetric and volumetric deliverable CH4 capacities of 0.24 g g−1 and 163 vol/vol (298 K, 5–65 bar) recorded for MFM-185a due to selective elongation of tubular cages. The dynamics of molecular rotors in deuterated MFM-180a-d16 and MFM-181a-d16 were investigated by variable-temperature 2H solid-state NMR spectroscopy to reveal the reorientation mechanisms within these materials. Analysis of the flipping modes of the mobile phenyl groups, their rotational rates, and transition temperatures paves the way to controlling and understanding the role of molecular rotors through design of organic linkers within porous MOF materials. PMID:28280097

Comparative study on the performance of power and bandwidth efficient modulations in LMSS under fading and interference

NASA Technical Reports Server (NTRS)

Liu, Jian; Kim, Junghwan; Kwatra, S. C.; Stevens, Grady H.

1991-01-01

Aspects of error performance of various power and bandwidth efficient modulations for the land mobile satellite systems (LMSS) were investigated under multipath fading and interferences by using Monte-Carlo simulation. A differential detection for 16QAM (quadrature amplitude modulation) was proposed to cope with Ricean fading and Doppler shift. Computer simulation results show that the performance of 16QAM with differential detection is as good as that of 16PSK with coherent detection and 3 dB better than that of 16PSK with differential detection, although it degrades by about 4.5 dB as compared to 16QAM with coherent detection under an additive white Gaussian noise (AWGN) channel. For the nonlinear channels, 16QAM with modified signal constellations is introduced and analyzed. The simulation results show that the modified 16QAM exhibits a gain of 2.5 dB over 16PSK under traveling-wave tube nonlinearity, and about 4 dB gain over 16PSK at the bit error rate of 10 exp -5 under AWGN. Computer simulation results for modified 16 QAM under cochannel interference and adjacent-channel interference are also presented.

76 FR 63916 - Transcontinental Gas Pipe Line Company, LLC; Notice of Application

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-14

... associated storage deliverability and capacity at the Eminence Storage Field (Eminence) in Covington County... Caverns 1, 2, 3, and 4, and reduce deliverability and capacity from 20.5 Bcf to 15.025 Bcf in Caverns 5, 6, and 7. Transco also seeks to partially abandon the total storage capacity and deliverability...

20 CFR 638.812 - State and local taxation of Job Corps deliverers.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false State and local taxation of Job Corps deliverers. 638.812 Section 638.812 Employees' Benefits EMPLOYMENT AND TRAINING ADMINISTRATION, DEPARTMENT OF... § 638.812 State and local taxation of Job Corps deliverers. The Act provides that transactions conducted...

20 CFR 638.812 - State and local taxation of Job Corps deliverers.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 20 Employees' Benefits 3 2011-04-01 2011-04-01 false State and local taxation of Job Corps deliverers. 638.812 Section 638.812 Employees' Benefits EMPLOYMENT AND TRAINING ADMINISTRATION, DEPARTMENT OF... § 638.812 State and local taxation of Job Corps deliverers. The Act provides that transactions conducted...

Southeastern Virtual Institute for Health Equity and Wellness (SE VIEW) Phase 2

DTIC Science & Technology

2013-09-01

and sweet tea. • Switch to fat free or 1% milk • Limit consumption of 100% fruit juice to ½ cup per day. • Fruit smoothie taste testing. Youth...in popular beverages. • Deliverables: • Drink water to replace sugar sweetened beverages such as soda and sweet tea. • Switch to fat free or 1...examples of dairy products. • Switch to 1% or unflavored skim milk. • Try to consume reduced fat or low- fat cheese. • Dairy snack taste-testing

Using EnviroAtlas Data to Identify Cost-Effective Locations for ...

EPA Pesticide Factsheets

Manure Management Use Case A use case walks through an example application of how EnviroAtlas data, in conjunction with other available data or resources, may be used to address real-world questions. Use cases may be hypothetical or based on actual cases where EnviroAtlas has been used in decision making at the local, regional or national scale. The use case is a deliverable for the EnviroAtlas project under the SHC 1.62 and will be incorporated on the EnviroAtlas website.

Effects of secondary loudspeaker properties on broadband feedforward active duct noise control.

PubMed

Chan, Yum-Ji; Huang, Lixi; Lam, James

2013-07-01

Dependence of the performance of feedforward active duct noise control on secondary loudspeaker parameters is investigated. Noise reduction performance can be improved if the force factor of the secondary loudspeaker is higher. For example, broadband noise reduction improvement up to 1.6 dB is predicted by increasing the force factor by 50%. In addition, a secondary loudspeaker with a larger force factor was found to have quicker convergence in the adaptive algorithm in experiment. In simulations, noise reduction is improved in using an adaptive algorithm by using a secondary loudspeaker with a heavier moving mass. It is predicted that an extra broadband noise reduction of more than 7 dB can be gained using an adaptive filter if the force factor, moving mass and coil inductance of a commercially available loudspeaker are doubled. Methods to increase the force factor beyond those of commercially available loudspeakers are proposed.

Automated Neuropsychological Assessment Metrics, Version 4 (ANAM4): Examination of Select Psychometric Properties and Administration Procedures

DTIC Science & Technology

2016-12-01

2017 was approved in August 2016. The supplemental project has 2 primary objectives: • Recommend cognitive assessment tools/approaches ( toolkit ) from...strategies for use in future military-relevant environments The supplemental project has two primary deliverables: • Proposed Toolkit of cognitive...6 Vet Final Report and Cognitive performance recommendations through Steering Committee Task 7 Provide Toolkit Report 16 Months 8-12 Task 8

Project Turnover Deliverables for the SY Farm Enraf Annulus Leak Detectors

DOE Office of Scientific and Technical Information (OSTI.GOV)

SCAIEF, C.C.

2000-09-19

This document identifies the deliverables that ensure the end user of the SY Farm Enraf Annulus Leak Detectors (ALD) has all the documentation and training required for operating and maintaining the new system. All deliverable items checked on the Acceptance For Beneficial Use (ABU) form have been completed and are available to the end user. This document was written as required by HNF-IP-0842, Volume IV section 3.12 Acceptance of Structures, Systems, and Components for Beneficial Use. This document applies to the deliverable documentation required to operate and maintain the SY Farm Enraf ALD System. Appendix A provides a copy ofmore » the ABU form as listed in the appendix of TWR-4092, Engineering Task Plan for the New SY Farm Annulus Leak Detectors. This document attests that all required deliverable items checked on the ABU have been completed and are available to the end user.« less

26 CFR 301.7701(b)-0 - Outline of regulation provision for section 7701(b)-1 through (b)-9.

Code of Federal Regulations, 2010 CFR

2010-04-01

... with filing requirements. (A) General rule. (B) Exception. (d) Examples. (e) No lapse. (1) Residency in... statement. (1) General rule. (2) Exception. (e) Filing requirement disregarded. § 301.7701(b)-9Effective...) Application to aliens. (2) Non-application to citizens. (e) Examples. § 301.7701(b)-2Closer connection...

Deliverability and efficacy of R-CHOP chemotherapy in very elderly patients with diffuse large B-cell lymphoma: an Australian retrospective analysis.

PubMed

Millar, A; Ellis, M; Mollee, P; Cochrane, T; Fletcher, J; Caudron, A; Webster, B; Trotman, J

2015-11-01

Elderly patients with diffuse large B-cell lymphoma (DLBCL) have an inferior prognosis, due in part to advanced age and pre-existing comorbidities, with reduced tolerability and deliverability of standard R-CHOP chemotherapy. To examine the deliverability, toxicity and efficacy of R-CHOP and the prevalence of the germinal and non-germinal phenotype DLBCL in an elderly Australian cohort. This retrospective analysis included patients ≥75 years diagnosed with DLBCL. Comprehensive chemotherapy and toxicity data were collected for patients treated with R-CHOP. Baseline demographics and chemotherapy characteristics were compared with progression-free (PFS) and overall survival (OS). Immunohistochemical staining identified the prevalence of the non-germinal centre (non-GCB) phenotype. Of the 111 patients, 92 (83%) commenced R-CHOP with 26/92 (28%) receiving ≤4 cycles. Median average relative dose (ARD) was 0.80 (0.07-1.17). Median average relative dose intensity (ARDI) was 0.89 (0.33-1.18). Serious adverse events occurred in 77% of patients with ≥Gd3 adverse events in 74%. Overall response rate was 85%. Two-year PFS was 63% and OS 74%. ARD and performance status ≥2 were significant prognostic factors for PFS and OS but not ARDI. Non-GCB-phenotype was identified in 44/72 (61%) of patients with immunohistochemical data. Despite high response rates and respectable survival estimates, the absence of standard therapy in 17% of patients, and dose reductions and serious toxicity of R-CHOP in this Australian cohort highlights the need for the development of less toxic yet efficacious treatments for very elderly patients with DLBCL. The high prevalence of the non-GCB phenotype highlights the potential value of targeted biological therapy for this demographic. © 2015 Royal Australasian College of Physicians.

Natural gas: It's headed from surplus to shortage

DOE Office of Scientific and Technical Information (OSTI.GOV)

Parent, L.V.

1988-02-01

Reserve additions in the lower 48 states are not keeping up with the current rate of production, and deliverability surplus will soon become deliverability shortfall during periods of extended peak demand. Surplus deliverability will likely fade away, inasmuch as gas well completions are less than half of what they were when additions exceeded the current production rate of 16 tcf/year, and the outlook for a sharp increase in completions is bleak. Demand, lackluster before the recent cold weather, is likely to suffer some loss in markets where lower resid prices can switch loads back to oil. Year-end '87 price spikesmore » were a welcome relief to spot gas sellers, but low reside prices have already put a lid on what industrial users and power plants will pay. As an immature market struggles to develop structure in a quasi-deregulated environment, the Ferc is reduced to tinkering with the minutiae of Order 500, as it seeks to create a compromise that would be equally unsatisfactory to all. Canada is increasing its stake in the game. Canadian producers demonstrated their willingness to accept 1987's low price levels and be players. It will be another problem year for U.S. producers, as price relief for spot gas is more than offset by the Order 500 dilemma and drilling cost increases exceed wellhead price increases. Canadian gas will take a bigger piece of a desultory market. But pending shortfalls promise a better day for those with patience, stamina and deep pockets.« less

26 CFR 1.904-0 - Outline of regulation provisions for section 904.

Code of Federal Regulations, 2011 CFR

2011-04-01

... post-2002 unused foreign tax paid or accrued with respect to dividends from noncontrolled section 902.... (iii) Interaction with section 954(b)(4). (8) Examples. (d) [Reserved] (e) Financial services income...-through entities. (A) Rule. (B) Examples. (iv) Examples. (4) Definition of incidental income. (i) In...

26 CFR 1.904-0 - Outline of regulation provisions for section 904.

Code of Federal Regulations, 2010 CFR

2010-04-01

... carrybacks and carryovers. (h) Transition rules for carryovers and carrybacks of pre-2003 and post-2002.... (iii) Interaction with section 954(b)(4). (8) Examples. (d) [Reserved] (e) Financial services income...-through entities. (A) Rule. (B) Examples. (iv) Examples. (4) Definition of incidental income. (i) In...

The Challenge of Connecting the Dots in the B.R.A.I.N

PubMed Central

Devor, Anna; Bandettini, Peter A.; Boas, David A.; Bower, James M.; Buxton, Richard B.; Cohen, Lawrence B.; Dale, Anders M.; Einevoll, Gaute T.; Fox, Peter T.; Franceschini, Maria Angela; Friston, Karl J.; Fujimoto, James G.; Geyer, Marc A.; Greenberg, Joel H.; Halgren, Eric; Hämäläinen, Matti S.; Helmchen, Fritjof; Hyman, Bradley T.; Jasanoff, Alan; Jernigan, Terry L.; Judd, Lewis L.; Kim, Seong-Gi; Kleinfeld, David; Kopell, Nancy J.; Kutas, Marta; Kwong, Kenneth K.; Larkum, Matthew E.; Lo, Eng H.; Magistretti, Pierre J.; Mandeville, Joseph B.; Masliah, Eliezer; Mitra, Partha P.; Mobley, William C.; Moskowitz, Michael A.; Nimmerjahn, Axel; Reynolds, John H.; Rosen, Bruce R.; Salzberg, Brian M.; Schaffer, Chris B.; Silva, Gabriel A.; So, Peter T. C.; Spitzer, Nicholas C.; Tootell, Roger B.; Van Essen, David C.; Vanduffel, Wim; Vinogradov, Sergei A.; Wald, Larry L.; Wang, Lihong V.; Weber, Bruno; Yodh, Arjun G.

2013-01-01

The Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative has focused scientific attention on the necessary tools to understand the human brain and mind. Here, we outline our collective vision for what we can achieve within a decade with properly targeted efforts, and discuss likely technological deliverables and neuroscience progress. PMID:24139032

Select Generic Dry-Storage Pilot Plant Design for Safeguards and Security by Design (SSBD) per Used Fuel Campaign

DOE Office of Scientific and Technical Information (OSTI.GOV)

Demuth, Scott Francis; Sprinkle, James K.

As preparation to the year-end deliverable (Provide SSBD Best Practices for Generic Dry-Storage Pilot Scale Plant) for the Work Package (FT-15LA040501–Safeguards and Security by Design for Extended Dry Storage), the initial step was to select a generic dry-storage pilot plant design for SSBD. To be consistent with other DOE-NE Fuel Cycle Research and Development (FCR&D) activities, the Used Fuel Campaign was engaged for the selection of a design for this deliverable. For the work Package FT-15LA040501–“Safeguards and Security by Design for Extended Dry Storage”, SSBD will be initiated for the Generic Dry-Storage Pilot Scale Plant described by the layout ofmore » Reference 2. SSBD will consider aspects of the design that are impacted by domestic material control and accounting (MC&A), domestic security, and international safeguards.« less

Bilogy Machine Initiative: Developing Innovative Novel Methods to Improve Neuro-rehabilitation for Amputees and Treatment for Patients at Remote Sites with Acute Brain Injury

DTIC Science & Technology

2010-09-01

service to support the creation of both normative and pathological neuroinformatics databases. Project 3 Deliverable: The aim of this project is to...Gainesville, FL, 2010. D. Hammond, P. Vandergheynst, R. Gribonval, “ Wavelets on Graphs via Spectral Graph Theory,” Applied Computational and...the Phantom Experiments,” International Conference on Electrical Bioimpedance, April 4-8-, Gainesville, FL, 2010. 21 D. Hammond, “ Wavelets on

Designer bFGF-incorporated d-form self-assembly peptide nanofiber scaffolds to promote bone repair.

PubMed

He, Bin; Ou, Yunsheng; Chen, Shuo; Zhao, Weikang; Zhou, Ao; Zhao, Jinqiu; Li, Hong; Jiang, Dianming; Zhu, Yong

2017-05-01

d-Form and l-form peptide nanofiber scaffolds can spontaneously form stable β-sheet secondary structures and nanofiber hydrogel scaffolds, and hold some promise in hemostasis and wound healing. We report here on the synthetic self-assembling peptide d-RADA16 and l-RADA16 are both found to produce stable β-sheet secondary structure and nanofiber hydrogel scaffolds based on circular dichroism (CD) spectroscopy, transmission electron microscopy (TEM) and rheology analysis etc. d-RADA16 hydrogel and l-RADA16 hydrogel can enhance obvious bone repair in femoral condyle defects of the Sprague-Dawley (SD) rat model compared to PBS treatment. Based on micro-computed tomography (CT), it was revealed that d-RADA16 hydrogel and l-RADA16 hydrogel were capable to obtain the extensive bone healing. Histological evaluation also found that these two hydrogels facilitate the presence of more mature bone tissue within the femoral condyle defects. Additionally, d-RADA16 hydrogel showed some potential in storing and releasing basic-fibroblast growth factor (bFGF) which was able to further promote bone regeneration based on micro-CT analysis. These results indicate that d-form peptide nanofiber hydrogel have some special capacity for bone repair. Copyright © 2016 Elsevier B.V. All rights reserved.

Performance Oriented Packaging Testing of Wirebound Wood Box Containing Two M2A1 Ammunition Boxes for Packing Group II Hazardous Materials

DTIC Science & Technology

1992-01-01

00-892-4302 FUZE M557 8861213 1.1B 0106 16 19.4 N335 1390-01-080-4171 FUZE M557 8861213 1.4B 0257 16 19.4 N340 1390-00-574-7705 FUZE M739 8861213...1.1D 0408 16 20.9 N340-1390-01-080-9447 FUZE M739 8861213 1.2D 0409 16 20.9 N340 1390-01-132-7481 FUZE M739A1 8861213 1.2D 0409 16 20.9 N402 1390-00-764

An optimal system design process for a Mars roving vehicle

NASA Technical Reports Server (NTRS)

Pavarini, C.; Baker, J.; Goldberg, A.

1971-01-01

The problem of determining the optimal design for a Mars roving vehicle is considered. A system model is generated by consideration of the physical constraints on the design parameters and the requirement that the system be deliverable to the Mars surface. An expression which evaluates system performance relative to mission goals as a function of the design parameters only is developed. The use of nonlinear programming techniques to optimize the design is proposed and an example considering only two of the vehicle subsystems is formulated and solved.

30 CFR 250.115 - How do I determine well producibility?

Code of Federal Regulations, 2010 CFR

2010-07-01

... well is an oil well, you must conduct a production test that lasts at least 2 hours after flow stabilizes. (d) If the well is a gas well, you must conduct a deliverability test that lasts at least 2 hours... 30 Mineral Resources 2 2010-07-01 2010-07-01 false How do I determine well producibility? 250.115...

[Identification of Hydrocarbon-Oxidizing Dietzia Bacteria from Petroleum Reservoirs Based on Phenotypic Properties and Analysis of the 16S rRNA and gyrB Genes].

PubMed

Nazina, T N; Shumkova, E S; Sokolova, D Sh; Babich, T L; Zhurina, M V; Xue, Yan-Fen; Osipov, G A; Poltaraus, A B; Tourova, T P

2015-01-01

The taxonomic position of hydrocarbon-oxidizing bacterial strains 263 and 32d isolated from formation water of the Daqing petroleum reservoir (PRC) was determined by polyphasic taxonomy techniques, including analysis of the 16S rRNA and the gyrB genes. The major chemotaxonomic characteristics of both strains, including the IV type cell wall, composition of cell wall fatty acids, mycolic acids, and menaquinones, agreed with those typical of Dietzia strains. The DNA G+C content of strains 263 and 32d were 67.8 and 67.6 mol%, respectively. Phylogenetic analysis of the 16S rRNA gene of strain 32d revealed 99.7% similarity to the gene of D. maris, making it possible to identify strain 32d as belonging to this species. The 16S rRNA gene sequence of strain 263 exhibited 99.7 and 99.9% similarity to those of D. natronolimnaea and D. cercidiphylli YIM65002(T), respectively. Analysis of the gyrB genes of the subterranean isolates and of a number of Dietzia type strains confirmed classiffication of strain 32d as a D. maris strain and of strain 263, as a D. natronolimnaea strain. A conclusion was made concerning higher resolving power of phylogenetic analysis of the gyrB gene compared to the 16S rRNA gene analysis in the case of determination of the species position of Dietzia isolates.

Molecular characterization of phytoplasma associated with four important ornamental plant species in India and identification of natural potential spread sources.

PubMed

Gopala; Rao, G P

2018-02-01

Phytoplasma suspected symptoms of phyllody, witches' broom, leaf yellowing, stunting and little leaf were observed in Chrysanthemum morifolium, Bougainvillea glabra, Jasminum sambac and Callistephus chinensis during survey of flower nurseries and experimental ornamental fields at Delhi, Maharashtra, Tamil Nadu and Karnataka from 2014 to 2016. Pleomorphic bodies typical to phytoplasma structures were observed in the phloem sieve elements of ultrathin sections of all the four symptomatic ornamental plants (stem tissue) in transmission electron microscope. Amplification of 1.8 and 1.2 kb phytoplasma DNA products was observed in all the four test plants in PCR assays using universal primer pairs P1/P7 followed by nested primer pair R16F2n/R16R2, respectively. Pairwise sequence comparison, phylogeny and virtual RFLP analysis of 16S rDNA sequences confirmed the association of two phytoplasma subgroups (16SrI-B and 16SrII-D) in four ornamental plant species. ' Ca. P. aurantifolia ' subgroup D (16SrII-D) was found associated with chrysanthemum phyllody and leaf yellowing at Delhi and Tamil Nadu, bougainvillea little leaf and yellowing at Delhi and Chinese aster phyllody at Bengaluru, Karnataka. However, jasmine little leaf and yellowing at Bengaluru, Karnataka and chrysanthemum stunting at Pune were found to be associated with ' Ca . P. asteris ' subgroup B-related strains (16SrI-B). The identification of 16SrII-D subgroup phytoplasma infecting bougainvillea and 16SrI-B subgroup infecting jasmine are the new reports to the world. Besides weed species, Cannabis sativa showing witches' broom in jasmine fields at Bengaluru and Parthenium hysterophorus showing witches' broom symptoms in chrysanthemum fields at Delhi were identified to be caused by phytoplasma strains classified under subgroups 16SrI-B and 16SrII-D, respectively, by PCR assays and 16Sr DNA sequence comparison analysis. Among the three major leafhopper species identified, only Hishimonas phycitis was identified positive for 16SrI-B and 16SrII-D subgroups of phytoplasmas from chrysanthemum fields at Delhi and jasmine fields at Bengaluru, respectively. The identity of similar phytoplasma strains infecting ornamental species in leafhopper and the weed species in the present study suggested that H. phycitis and weeds may act as potential natural sources for secondary spread of the identified phytoplasma strains.

Crystal structure and texture changes during thermal cycling of TATB

DOE Office of Scientific and Technical Information (OSTI.GOV)

Vogel, Sven C.; Yeager, John David

2015-02-20

Goals: Understand crystal structure and micro-structure changes during thermal cycling, understand reasons for ratcheting of TATB during thermal cycling, and Support of B61 LEP. Deliverables achieved: Completed in situ thermal cycling of loose powder and pressed pellet TATB on HIPPO, Quantified preferred orientation of pressed pellet, and quantified relative change of each of the six lattic parameters.

Landsat maps (phase V, deliverable 60), ASTER maps (phase V, deliverable 62), ASTER_DEM maps (phase V, deliverable 63), and spectral remote sensing in support of PRISM-II mineral resource assessment project, Islamic Republic of Mauritania (phase V, deliverables 61 and 64): Chapter E in Second projet de renforcement institutionnel du secteur minier de la République Islamique de Mauritanie (PRISM-II)

USGS Publications Warehouse

Rockwell, Barnaby W.; Knepper, Daniel H.; Horton, John D.

2015-01-01

The image products derived from Landsat TM and ASTER data enable the delineation of mineral groups across wide areas based on color response. Guides are provided that allow users to interpret these colors as to mineral group occurrence over lithologic units and known deposits. This information can be extrapolated to other geologically permissive tracts for various deposit types in the search for similar mineralogic responses that may be indicative of concealed deposits.

75 FR 22508 - Airworthiness Directives; Eurocopter France Model AS350B, BA, B1, B2, B3, C, D, and D1; AS 355E...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-29

... Airworthiness Directives; Eurocopter France Model AS350B, BA, B1, B2, B3, C, D, and D1; AS 355E, F, F1, F2, N... (b) None. Applicability (c) This AD applies to Model AS350B, BA, B1, B2, B3, C, D and D1; and AS 355E..., both dated November 16, 2005, is approved by the Director of the Federal Register as of May 14, 2010...

Effect of Pointing Error on the BER Performance of an Optical CDMA FSO Link with SIK Receiver

NASA Astrophysics Data System (ADS)

Nazrul Islam, A. K. M.; Majumder, S. P.

2017-12-01

An analytical approach is presented for an optical code division multiple access (OCDMA) system over free space optical (FSO) channel considering the effect of pointing error between the transmitter and the receiver. Analysis is carried out with an optical sequence inverse keying (SIK) correlator receiver with intensity modulation and direct detection (IM/DD) to find the bit error rate (BER) with pointing error. The results are evaluated numerically in terms of signal-to-noise plus multi-access interference (MAI) ratio, BER and power penalty due to pointing error. It is noticed that the OCDMA FSO system is highly affected by pointing error with significant power penalty at a BER of 10-6 and 10-9. For example, penalty at BER 10-9 is found to be 9 dB corresponding to normalized pointing error of 1.4 for 16 users with processing gain of 256 and is reduced to 6.9 dB when the processing gain is increased to 1,024.

CDC/NACCHO Accreditation Support Initiative: advancing readiness for local and tribal health department accreditation.

PubMed

Monteiro, Erinn; Fisher, Jessica Solomon; Daub, Teresa; Zamperetti, Michelle Chuk

2014-01-01

Health departments have various unique needs that must be addressed in preparing for national accreditation. These needs require time and resources, shortages that many health departments face. The Accreditation Support Initiative's goal was to test the assumption that even small amounts of dedicated funding can help health departments make important progress in their readiness to apply for and achieve accreditation. Participating sites' scopes of work were unique to the needs of each site and based on the proposed activities outlined in their applications. Deliverables and various sources of data were collected from sites throughout the project period (December 2011-May 2012). Awardees included 1 tribal and 12 local health departments, as well as 5 organizations supporting the readiness of local and tribal health departments. Sites dedicated their funding toward staff time, accreditation fees, completion of documentation, and other accreditation readiness needs and produced a number of deliverables and example documents. All sites indicated that they made accreditation readiness gains that would not have occurred without this funding. Preliminary evaluation data from the first year of the Accreditation Support Initiative indicate that flexible funding arrangements may be an effective way to increase health departments' accreditation readiness.

Recording Cultural Heritage Using Terrestrial Laserscanning - Dealing with the System, the Huge Datasets they Create and Ways to Extract the Necessary Deliverables you can Work with

NASA Astrophysics Data System (ADS)

Christofori, E.; Bierwagen, J.

2013-07-01

Recording Cultural Heritage objects using terrestrial laserscanning becomes more and more popular over the last years. Since terrestrial Laserscanning System (TLS) Manufacturers have strongly increased the amount and speed of data captured with a single scan at each system upgrade and cutting down system costs the use of TLS Systems for recording cultural heritage is an option for recording worth to think about beside traditional methods like Photogrammetric. TLS Systems can be a great tool for capturing complex cultural heritage object within a short amount of time beside the traditional methods but can be a nightmare to handle for further process if not used right while capturing. Furthermore TLS Systems still have to be recognized as survey equipment, even though some of the manufactures promote them as everyday tool. They have to be used in an intelligent way having in mind the clients and the individual cultural objects needs. Thus the efficient way to use TLS Systems for data recording becomes a relevant topic to deal with the huge Amount of data the Systems collect while recording. Already small projects can turn into huge Pointcloud Datasets that End user, like Architects or Archaeologist neither can't deal with as their technical equipment doesn't fit the requirements of the Dataset nor do they have the software tools to use the Data as the current software tools still are high prized. Even the necessary interpretation of the Dataset can be a tough task if the people who have to work on with the Pointcloud aren't educated right in order to understand TLS and the results it creates. The use of TLS Systems has to have in mind the project requirements of the individual Heritage Object, like the required accuracy, standards for Levels of Details (e.g. "Empfehlungen für die Baudokumentation, Günther Eckstein, Germany"), the required kind of Deliverables (Visualization, 2D Drawings, True Deformation Drawings, 3D Models, BIM or 4D - Animations) as well as the Projects budget, restrictions and special conditions of the object. And if it's used in the right way TLS will fulfil all request and furthermore create additional recording, deliverable and financial benefit. Christofori und Partner is working with TLS Systems on cultural heritage Objects since 2005 trying to optimize the use of these systems (even in combining different systems like TLS, photogrammetric or new techniques) as well as creating useable deliverables for the Clients (Owner, Conservator, Designers and the Public) they can work on with.

Micro and Nano-mediated 3D Cardiac Tissue Engineering

DTIC Science & Technology

2012-09-01

as many forms of heart disease involve stiff scar tissue in the heart. Research Group: Larry Schook Period Sept ’11 to Sept ‘12 Deliverables...to their influence on cell attachment. Modeling disease systems and using recently developed biomaterials on PC biosensors with this new technique...will allow new insight into these problems, enabling researchers to develop more successful therapeutic approaches to clinical disease . VII

Proceedings of the 16th Project Integration Meeting

NASA Technical Reports Server (NTRS)

Mcdonald, R. R.

1980-01-01

The principal achievement of the Low Cost Solar Array Project in 1980 was the attainment of $2.80/Wp Technical Readiness, and that processes and equipment now commercially available can make possible a deliverable product in 1982. A prototype array for intermediate load applications was demonstrated using frameless modules. It was proof tested to 40 lb/sq ft loading, and priced at $24/sq m, including array fabrication, module installation, shipping to the site and site installation for quantities of 20 MW.

Microbiological and chemical transformations of argentatin B.

PubMed

Maatooq, Galal T

2003-01-01

Argentatin B is a naturally occurring tetracyclic triterpene isolated from Parthenium argentatum x P. tomentosa. It was microbiologically transformed to 16, 24-epoxycycloartan-3alpha, 25-diol, (isoargentatin D), by Nocardia corallina var. taoka ATCC 31338, Mycobacterium species NRRL B3683 and Septomyxa affinis ATCC 6737. The later microbe also produced 16, 24-epoxycycloartan-3beta, 25-diol (argentatin D) and 1, 2-didehydroargentatin B, (isoargentatin D). Sodium hydroxide converted argentatin B to argentatin D and isoargentatin D. Hydrochloric acid treatment gave cycloartan-25-ol-3, 24-dione. Cerium sulfate/sulfuric acid/aqueous methanol induced scission of the isopropanol moiety and provided an isomeric mixture of 24-methoxy-25-27-trinorargentatin B. Oxidation of this isomeric mixture with pyridinium chlorochromate, selectively, attacked the isomer with the equatorial proton at position-24 to give the corresponding lactone, 24-oxo-25-27-trinorargentatin B. The produced compounds were characterized by spectroscopic methods.

Improvements Needed in U.S. Special Operations Command Global Battlestaff and Program Support Contract Oversight

DTIC Science & Technology

2013-04-26

and 6-8 books annually. Some deliverables are due “as required.” This is because the mission of the IATF is dependent upon real-world events and...six lines of investigation (4.1.18). Some deliverables do not have specific due dates or schedules because the mission of the IATF is dependent upon...34 This is because the mission of the IATF is dependent upon real-world events and deliverables are linked to dynamic findings from the SOCOM GSC

26 CFR 1.482-0 - Outline of regulations under section 482.

Code of Federal Regulations, 2010 CFR

2010-04-01

...) Property or services. (4) Special circumstances. (i) Market share strategy. (ii) Different geographic markets. (A) In general. (B) Example. (C) Location savings. (D) Example. (iii) Transactions ordinarily not... of multiple year data. (C) Comparable effect over comparable period. (D) Applications of methods...

Incorporating deliverable monitor unit constraints into spot intensity optimization in intensity modulated proton therapy treatment planning

PubMed Central

Cao, Wenhua; Lim, Gino; Li, Xiaoqiang; Li, Yupeng; Zhu, X. Ronald; Zhang, Xiaodong

2014-01-01

The purpose of this study is to investigate the feasibility and impact of incorporating deliverable monitor unit (MU) constraints into spot intensity optimization in intensity modulated proton therapy (IMPT) treatment planning. The current treatment planning system (TPS) for IMPT disregards deliverable MU constraints in the spot intensity optimization (SIO) routine. It performs a post-processing procedure on an optimized plan to enforce deliverable MU values that are required by the spot scanning proton delivery system. This procedure can create a significant dose distribution deviation between the optimized and post-processed deliverable plans, especially when small spot spacings are used. In this study, we introduce a two-stage linear programming (LP) approach to optimize spot intensities and constrain deliverable MU values simultaneously, i.e., a deliverable spot intensity optimization (DSIO) model. Thus, the post-processing procedure is eliminated and the associated optimized plan deterioration can be avoided. Four prostate cancer cases at our institution were selected for study and two parallel opposed beam angles were planned for all cases. A quadratic programming (QP) based model without MU constraints, i.e., a conventional spot intensity optimization (CSIO) model, was also implemented to emulate the commercial TPS. Plans optimized by both the DSIO and CSIO models were evaluated for five different settings of spot spacing from 3 mm to 7 mm. For all spot spacings, the DSIO-optimized plans yielded better uniformity for the target dose coverage and critical structure sparing than did the CSIO-optimized plans. With reduced spot spacings, more significant improvements in target dose uniformity and critical structure sparing were observed in the DSIO- than in the CSIO-optimized plans. Additionally, better sparing of the rectum and bladder was achieved when reduced spacings were used for the DSIO-optimized plans. The proposed DSIO approach ensures the deliverability of optimized IMPT plans that take into account MU constraints. This eliminates the post-processing procedure required by the TPS as well as the resultant deteriorating effect on ultimate dose distributions. This approach therefore allows IMPT plans to adopt all possible spot spacings optimally. Moreover, dosimetric benefits can be achieved using smaller spot spacings. PMID:23835656

Advantages and limitations of navigation-based multicriteria optimization (MCO) for localized prostate cancer IMRT planning

DOE Office of Scientific and Technical Information (OSTI.GOV)

McGarry, Conor K., E-mail: conor.mcgarry@belfasttrust.hscni.net; Bokrantz, Rasmus; RaySearch Laboratories, Stockholm

2014-10-01

Efficacy of inverse planning is becoming increasingly important for advanced radiotherapy techniques. This study’s aims were to validate multicriteria optimization (MCO) in RayStation (v2.4, RaySearch Laboratories, Sweden) against standard intensity-modulated radiation therapy (IMRT) optimization in Oncentra (v4.1, Nucletron BV, the Netherlands) and characterize dose differences due to conversion of navigated MCO plans into deliverable multileaf collimator apertures. Step-and-shoot IMRT plans were created for 10 patients with localized prostate cancer using both standard optimization and MCO. Acceptable standard IMRT plans with minimal average rectal dose were chosen for comparison with deliverable MCO plans. The trade-off was, for the MCO plans, managedmore » through a user interface that permits continuous navigation between fluence-based plans. Navigated MCO plans were made deliverable at incremental steps along a trajectory between maximal target homogeneity and maximal rectal sparing. Dosimetric differences between navigated and deliverable MCO plans were also quantified. MCO plans, chosen as acceptable under navigated and deliverable conditions resulted in similar rectal sparing compared with standard optimization (33.7 ± 1.8 Gy vs 35.5 ± 4.2 Gy, p = 0.117). The dose differences between navigated and deliverable MCO plans increased as higher priority was placed on rectal avoidance. If the best possible deliverable MCO was chosen, a significant reduction in rectal dose was observed in comparison with standard optimization (30.6 ± 1.4 Gy vs 35.5 ± 4.2 Gy, p = 0.047). Improvements were, however, to some extent, at the expense of less conformal dose distributions, which resulted in significantly higher doses to the bladder for 2 of the 3 tolerance levels. In conclusion, similar IMRT plans can be created for patients with prostate cancer using MCO compared with standard optimization. Limitations exist within MCO regarding conversion of navigated plans to deliverable apertures, particularly for plans that emphasize avoidance of critical structures. Minimizing these differences would result in better quality treatments for patients with prostate cancer who were treated with radiotherapy using MCO plans.« less

78 FR 4305 - Common Crop Insurance Regulations; Florida Citrus Fruit Crop Insurance Provisions; Correction

Federal Register 2010, 2011, 2012, 2013, 2014

2013-01-22

... and need to be clarified. First, the example in section 10(b)(6) that was proposed to be revised was mistakenly omitted in the revised text. This amendment adds the revised example back into section 10(b)(6... Sec. 457.107 as follows: 0 a. By revising section 10(b)(6); 0 b. By revising the added section 10(d)(6...

16 CFR 1015.16 - Exemptions (5 U.S.C. 552(b)).

Code of Federal Regulations, 2010 CFR

2010-01-01

... 16 Commercial Practices 2 2010-01-01 2010-01-01 false Exemptions (5 U.S.C. 552(b)). 1015.16 Section 1015.16 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION GENERAL PROCEDURES FOR DISCLOSURE... particular types of matters to be withheld. (d) Trade secrets and commercial or financial information...

Aquifer-test data and borehole flow test results from monitoring well 16P52 at the South Trend development area number 1, McKinley County, New Mexico

USGS Publications Warehouse

Stevens, Ken

1984-01-01

Mobil Oil Corporation personnel have designated at least four sandstone intervals, A-D (top to bottom), on the single-point resistivity logs of wells drilled in the South Trend Development Area. This report presents time-drawdown data reported by Mobil Oil Corporation from singly (A or B or C or D sandstone interval) and multiply (A, B, C, and D sandstone Intervals) completed wells for the August 16-17, 1982 aquifer test at the South Trend Development Area Site 1. This report also describes the results of flowmeter and brine-injection tests by the U.S. Geological Survey in monitoring well 16P52. Well 16P52 is open to sandstone intervals A, B, C, and D. On July 26, 1982, water was injected at a rate of 1.43 cubic feet per minute above the A sandstone interval in well 16P52. Based on flowmeter data, the calculated rates of flow were 1.23 cubic feet per minute between the A and B sandstone intervals, 0.63 cubic foot per minute between the B and C sandstone intervals, and less than 0.17 cubic foot per minute between the C and D sandstone intervals. Based upon brine-slug-injection tests conducted during August 1982, the calculated flow rates between sandstone intervals A and B are as follows: 0.01 cubic foot per minute upward flow (B to A) about 5 hours after pumping began for the aquifer test; 0.004 cubic foot per minute upward flow (B to A) about 21 hours after pumping began; and 0.0 cubic foot per minute about 46 hours after the pump was turned off. All other brine-slug-injection tests measured no flow.

Linking secondary school physical education with community sport and recreation for girls: a process evaluation.

PubMed

Casey, Meghan M; Telford, Amanda; Mooney, Amanda; Harvey, Jack T; Eime, Rochelle M; Payne, Warren R

2014-10-06

The purpose of this study was to undertake a process evaluation to examine the reach, adoption and implementation of a school-community linked physical activity (PA) program for girls aged 12 - 15 years (School Years 7 - 9) using the RE-AIM framework. Various approaches were used to assess 'reach', 'adoption' and implementation: (a) a school environment survey of intervention schools (n = 6); (b) teacher feedback regarding the professional development component (91.1% response rate) and lesson implementation (60.8% response rate); and (c) post-intervention focus group interviews with physical education (PE) teachers (n = 29), students (n = 125), coaches (n = 13) and instructors (n = 8) regarding program experiences. Reach and Adoption: Seven schools (n = 1491 Year 7-9 female student enrolment; 70% adoption rate), five tennis clubs, eight football clubs and five leisure centres participated in the program during 2011. Program design and professional development opportunities (training, resource manual and opportunities to work with coaches and instructors during PE classes) supported implementation and student engagement in PA. However, there was a lack of individual and organisational readiness to adopt program principles. For some deliverers there were deeply embedded ideologies that were not aligned with the Game Sense teaching approach upon which the program was based. Further, cognitive components of the program such as self-management were not widely adopted as other components of the program tended to be prioritised. The program design and resources supported the success of the program, however, some aspects were not implemented as intended, which may have affected the likelihood of achieving further positive outcomes. Barriers to program implementation were identified and should be considered when designing school-community linked interventions. In particular, future programs should seek to assess and adjust for organizational readiness within the study design. For example, shared commitment and abilities of program deliverers to implement the program needs to be determined to support program implementation. ACTRN12614000446662. April 30th 2014.

Accelerated Innovation Pilot

NASA Technical Reports Server (NTRS)

Davis, Jeffrey

2012-01-01

Opportunities: I. Engage NASA team (examples) a) Research and technology calls . provide suggestions to AES, HRP, OCT. b) Use NASA@Work to solicit other ideas; (possibly before R+D calls). II. Stimulate collaboration (examples) a) NHHPC. b) Wharton Mack Center for Technological Innovation (Feb 2013). c) International ] DLR ] :envihab (July 2013). d) Accelerated research models . NSF, Myelin Repair Foundation. III. Engage public Prizes (open platform: InnoCentive, yet2.com, NTL; Rice Business Plan, etc.) IV. Use same methods to engage STEM.

The Traveling Wave Amplifier as a Bistable Oscillator

DTIC Science & Technology

1956-01-01

2n)t + 5/4 e V m Vtt Cos(m-2n)t + 5/16 e vm VA Gos(m+4n)t + 5/16 e vm Vtt Cos(m-4n)t Again Collecting Terms E 0 = 1/2 b Vrt +l/2bVfi + 3/8 d Vrft...3 ( ~ c V ft + 5/8 e VA + 15/4 e V ~ V J ’ + 15/8 e V in V n) + Cos2mt (1/2 b Vfn + 1/2 d Vrt + 3/2 d V~ V~) III-3 Again Collecting Terms (Cont’d

78 FR 39901 - Amendments to the 2013 Mortgage Rules Under the Equal Credit Opportunity Act (Regulation B), Real...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-02

... compensation restrictions under Sec. 1026.36(d) (for example, if a creditor wishes to pay individual loan... compensation for the first time period). See comment 36(d)(1)-3.v.C, as proposed to be revised. For example... 10-percent limit would set an upper limit on such behavior). \\17\\ For example, the 2013 Loan...

Cartridge output testing - Methods to overcome closed-bomb shortcomings

NASA Technical Reports Server (NTRS)

Bement, Laurence J.; Schimmel, Morry L.

1991-01-01

Although the closed-bomb test has achieved virtually universal acceptance for measuring the output performance of pyrotechnic cartridges, there are serious shortcomings in its ability to quantify the performance of cartridges used as energy sources for pyrotechnic-activated mechanical devices. This paper presents several examples of cartridges (including the NASA Standard Initiator NSI) that successfully met closed-bomb performance requirements, but resulted in functional failures in mechanisms. To resolve these failures, test methods were developed to demonstrate a functional margin, based on comparing energy required to accomplish the function to energy deliverable by the cartridge.

Comparison of stapedotomy minus prosthesis, circumferential stapes mobilization, and small fenestra stapedotomy for stapes fixation.

PubMed

Acar, Gül Ozbilen; Kivekäs, Ilkka; Hanna, Bassem M; Huang, Lin; Gopen, Quinton; Poe, Dennis S

2014-04-01

To compare the outcomes of 3 surgical techniques for primary stapes fixation: stapedotomy minus prosthesis (STAMP), circumferential stapes mobilization (CSM), and small fenestra stapedotomy (SFS). Retrospective review of 277 primary cases operated for stapes fixation from 1997 to 2007. Tertiary academic center. Consecutive adult and pediatric cases operated for conductive hearing loss because of stapes fixation. STAMP was performed for otosclerosis limited to the anterior footplate, CSM was conducted for congenital stapes fixation, SFS was performed for more extensive otosclerosis or anatomic contraindications to STAMP/CSM. Pure-tone audiometry was performed preoperatively and postoperatively (3-6 wk) and the most recent long-term results (≥ 12 mo). Ninety-nine ears in 90 patients had audiologic follow-up data over 12 months. Sixty-seven ears (68%) underwent SFS, 16 (16%) STAMP, and 16 (16%) CSM. There was significant improvement in average air conduction (AC) thresholds and air-bone gap (ABG) for all techniques. Mean ABG for SFS closed from 29 to 7.1 dB (SD, 6.0), for STAMP from 29 to 3.8 dB (SD, 5.8 dB), and for CSM from 34 to 20 dB (SD, 8.2 dB). AC results were better in the STAMP than in the SFS group, especially in high frequencies. Bone conduction improvements were seen in all groups, highest in STAMP (4.3 dB) and CSM (3.8 dB) groups, but the differences between groups were not statistically significant. Satisfactory hearing results were achieved with all the techniques, and STAMP showed better hearing outcomes, especially in high frequencies. CSM is a good option for children and patients in whom it is desirable to avoid a footplate fenestration or prosthesis. CSM and STAMP had significantly higher rates of revision for refixation than SFS.

Flexible long-chain-linker constructed Ni-based metal-organic frameworks with 1D helical channel and their pseudo-capacitor behavior studies

NASA Astrophysics Data System (ADS)

Wang, Kuaibing; Wang, Zikai; Wang, Xin; Zhou, Xueqin; Tao, Yuehong; Wu, Hua

2018-02-01

Two novel and isostructural Ni-based MOFs with topological symbol of 422·54·62, namely [Ni2(TATB)2(L)2(H2O)], have successfully synthesized, where L is the flexibly N-donor bid (1,10-bisimidazoledecane) or btd (1,10-bistriazoledecane) linker and TATB is the deprotonation mode from 4,4‧,4″-s-triazine-2,4,6-triyl-tribenzoic acid (H3TATB). Two types of left- and right-handed helical channels with mean diameter of 11 Å results in large void space in 3D network. When directly use as electrode materials, the as-synthesized Ni-MOFs single-crystal electrodes behave as pseudo-capacitor and deliver high gravimetric capacitance with superior energy deliverable ability and cycling stability. For example, the maximum gravimetric capacitance is 705 F g-1 with the energy density of 29.6 Wh kg-1 at a current density of 1 A g-1. Even after 5000 continuous cycles, the capacitance retention maintains at 92.1%. The good electrochemical performance should be ascribed to the 1D helical channels facilitating the diffusion of OH-. Furthermore, the low bulk solution (0.46 and 0.50 Ω) and charge-transfer resistances accelerate the contact between OH- and active species in the electrode, and consequently result in efficiency Faradaic reaction. This work opens a new way for the directly application of 3D topological MOFs single-crystal with novel interior structures especially porous and channel-like architectures in electronic energy storage field.

Dinuclear copper(II) complexes with {Cu2(mu-hydroxo)bis(mu-carboxylato)}+ cores and their reactions with sugar phosphate esters: A substrate binding model of fructose-1,6-bisphosphatase.

PubMed

Kato, Merii; Tanase, Tomoaki; Mikuriya, Masahiro

2006-04-03

Reactions of CuX2.nH2O with the biscarboxylate ligand XDK (H2XDK = m-xylenediamine bis(Kemp's triacid imide)) in the presence of N-donor auxiliary ligands yielded a series of dicopper(II) complexes, [Cu2(mu-OH)(XDK)(L)2]X (L = N,N,N',N'-tetramethylethylenediamine (tetmen), X = NO3 (1a), Cl (1b); L = N,N,N'-trimethylethylenediamine (tmen), X = NO3 (2a), Cl (2b); L =2,2'-bipyridine (bpy), X = NO3 (3); L = 1,10-phenanthroline (phen), X = NO3 (4); L = 4,4'-dimethyl-2,2'-bipyridine (Me2bpy), X = NO3 (5); L = 4-methyl-1,10-phenanthroline (Mephen), X = NO3 (6)). Complexes 1-6 were characterized by X-ray crystallography (Cu...Cu = 3.1624(6)-3.2910(4) A), and the electrochemical and magnetic properties were also examined. Complexes 3 and 4 readily reacted with diphenyl phosphoric acid (HDPP) or bis(4-nitrophenyl) phosphoric acid (HBNPP) to give [Cu2(mu-phosphate)(XDK)(L)2]NO3 (L = bpy, phosphate = DPP (11); L = phen, phosphate = DPP (12), BNPP (13)), where the phsophate diester bridges the two copper ions in a mu-1,3-O,O' bidentate fashion (Cu...Cu = 4.268(3)-4.315(1) A). Complexes 4 and 6 with phen and Mephen have proven to be good precursors to accommodate a series of sugar monophosphate esters (Sugar-P) onto the biscarboxylate-bridged dicopper centers, yielding [Cu2(mu-Sugar-P)(XDK)(L)2] (Sugar-P = alpha-D-Glc-1-P (23a and b), D-Glc-6-P (24a and b), D-Man-6-P (25a), D-Fru-6-P (26a and b); L = phen (a), Mephen (b)) and [Cu2(mu-Gly-n-P)(XDK)(Mephen)2] (Gly-n-P = glycerol n-phosphate; n = 2 (21), 3 (22)), where Glc, Man, and Fru are glucose, mannose, and fructose, respectively. The structure of [Cu2(mu-MNPP)(XDK)(phen)2(CH3OH)] (20) was characterized as a reference compound (H2MNPP = 4-nitrophenyl phosphoric acid). Complexes 4 and 6 also reacted with d-fructose 1,6-bisphosphate (D-Fru-1,6-P2) to afford the tetranuclear copper(II) complexes formulated as [Cu4(mu-D-Fru-1,6-P2)(XDK)2(L)4] (L = phen (27a), Mephen (27b)). The detailed structure of 27a was determined by X-ray crystallography to involve two different tetranuclear complexes with alpha- and beta-anomers of D-Fru-1,6-P2, [Cu4(mu-alpha-D-Fru-1,6-P2)(XDK)2(phen)4] and [Cu4(mu-beta-D-Fru-1,6-P2)(XDK)2(phen)4], in which the D-Fru-1,6-P2 tetravalent anion bridges the two [Cu2(XDK)(phen)2]2+ units through the C1 and C6 phosphate groups in a mu-1,3-O,O' bidentate fashion (Cu...Cu = 4.042(2)-4.100(2) A). Notably, the structure with alpha-D-Fru-1,6-P2 demonstrated the presence of a strong hydrogen bond between the C2 hydroxyl group and the C1 phosphate oxygen atom, which may support the previously proposed catalytic mechanism in the active site of fructose-1,6-bisphosphatase.

Application of fuzzy logic-neural network based reinforcement learning to proximity and docking operations: Special approach/docking testcase results

NASA Technical Reports Server (NTRS)

Jani, Yashvant

1993-01-01

As part of the RICIS project, the reinforcement learning techniques developed at Ames Research Center are being applied to proximity and docking operations using the Shuttle and Solar Maximum Mission (SMM) satellite simulation. In utilizing these fuzzy learning techniques, we use the Approximate Reasoning based Intelligent Control (ARIC) architecture, and so we use these two terms interchangeably to imply the same. This activity is carried out in the Software Technology Laboratory utilizing the Orbital Operations Simulator (OOS) and programming/testing support from other contractor personnel. This report is the final deliverable D4 in our milestones and project activity. It provides the test results for the special testcase of approach/docking scenario for the shuttle and SMM satellite. Based on our experience and analysis with the attitude and translational controllers, we have modified the basic configuration of the reinforcement learning algorithm in ARIC. The shuttle translational controller and its implementation in ARIC is described in our deliverable D3. In order to simulate the final approach and docking operations, we have set-up this special testcase as described in section 2. The ARIC performance results for these operations are discussed in section 3 and conclusions are provided in section 4 along with the summary for the project.

A 16.9 dBm InP DHBT W-band power amplifier with more than 20 dB gain

NASA Astrophysics Data System (ADS)

Hongfei, Yao; Yuxiong, Cao; Danyu, Wu; Xiaoxi, Ning; Yongbo, Su; Zhi, Jin

2013-07-01

A two-stage MMIC power amplifier has been realized by use of a 1-μm InP double heterojunction bipolar transistor (DHBT). The cascode structure, low-loss matching networks, and low-parasite cell units enhance the power gain. The optimum load impedance is determined from load-pull simulation. A coplanar waveguide transmission line is adopted for its ease of fabrication. The chip size is 1.5 × 1.7 mm2 with the emitter area of 16 × 1 μm × 15 μm in the output stage. Measurements show that small signal gain is more than 20 dB over 75.5-84.5 GHz and the saturated power is 16.9 dBm @ 79 GHz with gain of 15.2 dB. The high power gain makes it very suitable for medium power amplification.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jian, Tian; Lopez, Gary V.; Wang, Lai-Sheng, E-mail: Lai-Sheng-Wang@brown.edu

We report the observation of a manganese-centered tubular boron cluster (MnB{sub 16}{sup −}), which is characterized by photoelectron spectroscopy and ab initio calculations. The relatively simple pattern of the photoelectron spectrum indicates the cluster to be highly symmetric. Ab initio calculations show that MnB{sub 16}{sup −} has a Mn-centered tubular structure with C{sub 4v} symmetry due to first-order Jahn-Teller effect, while neutral MnB{sub 16} reduces to C{sub 2v} symmetry due to second-order Jahn-Teller effect. In MnB{sub 16}{sup −}, two unpaired electrons are observed, one on the Mn 3d{sub z{sup 2}} orbital and another on the B{sub 16} tube, making itmore » an unusual biradical. Strong covalent bonding is found between the Mn 3d orbitals and the B{sub 16} tube, which helps to stabilize the tubular structure. The current result suggests that there may exist a whole class of metal-stabilized tubular boron clusters. These metal-doped boron clusters provide a new bonding modality for transition metals, as well as a new avenue to design boron-based nanomaterials.« less

WE-G-18C-09: Separating Perfusion and Diffusion Components From Diffusion Weighted MRI of Rectum Tumors Based On Intravoxel Incoherent Motion (IVIM) Analysis

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tyagi, N; Wengler, K; Mazaheri, Y

2014-06-15

Purpose: Pseudodiffusion arises from the microcirculation of blood in the randomly oriented capillary network and contributes to the signal decay acquired using a multi-b value diffusion weighted (DW)-MRI sequence. This effect is more significant at low b-values and should be properly accounted for in apparent diffusion coefficient (ADC) calculations. The purpose of this study was to separate perfusion and diffusion component based on a biexponential and a segmented monoexponential model using IVIM analysis Methods. The signal attenuation is modeled as S(b) = S0[(1−f)exp(−bD) + fexp(−bD*)]. Fitting the biexponetial decay leads to the quantification of D, the true diffusion coefficient, D*,more » the pseudodiffusion coefficient, and f, the perfusion fraction. A nonlinear least squares fit and two segmented monoexponential models were used to derive the values for D, D*,‘and f. In the segmented approach b = 200 s/mm{sup 2} was used as the cut-off value for calculation of D. DW-MRI's of a rectum cancer patient were acquired before chemotherapy, before radiation therapy (RT), and 4 weeks into RT and were investigated as an example case. Results: Mean ADC for the tumor drawn on the DWI cases was 0.93, 1.0 and 1.13 10{sup −3}×mm{sup 2}/s before chemotherapy, before RT and 4 weeks into RT. The mean (D.10{sup −3} × mm{sup 2}/s, D* 10{sup −3} × mm{sup 2}/s, and f %) based on biexponential fit was (0.67, 18.6, and 27.2%), (0.72, 17.7, and 28.9%) and (0.83,15.1, and 30.7%) at these time points. The mean (D, D* f) based on segmented fit was (0.72, 10.5, and 12.1%), (0.72, 8.2, and 17.4%) and (.82, 8.1, 16.5%) Conclusion: ADC values are typically higher than true diffusion coefficients. For tumors with significant perfusion effect, ADC should be analyzed at higher b-values or separated from the perfusion component. Biexponential fit overestimates the perfusion fraction because of increased sensitivity to noise at low b-values.« less

United States and Mexican State Directors of Special Education: Information Exchange Meeting, February 7-9, 1999. Proceedings Document. Final Report, Deliverable-Task 2-3.1b.

ERIC Educational Resources Information Center

National Association of State Directors of Special Education, Alexandria, VA.

This proceedings documents a meeting designed to allow state directors of special education to exchange information about the special education systems in Mexico and the United States, to discuss common issues and concerns related to the provision of educational services for children and youth with disabilities, and to establish collegial…

Synthesis of High-Speed Digital Systems.

DTIC Science & Technology

1985-11-08

1 (sub2 sub 16 2 (sub3 sub 16) 3 (sub4 sub 16) 4 (eub5 sub 16) 5 (sub6 sub 16) 6 ( sub7 sub 16) 7 (addi add 16) 8 (add2 add 16) 9 (add3 add 16) 10...seB uub5 J2 16 se5) 15 (se6 sub6 JI 16 soO) 18 (se7 sub7 J5 16 se7) 17 (aol addi Dl 16 aol) 18 (a921 add2 add7 18 a02) 19 (&922 add2 add5 16 a02) 20...de4l D4 add4 16 de4) 33 Wd942 D4 sub4 16 de4) 34 (de~i D5 sub7 16 de5) 35 (deS2 D5 add8 16 deS) 36 (jell Ji add7 16 jel) 37 (je12 JI D5 16 jel) 38 (je2

16Oxygen irradiation enhances cued fear memory in B6D2F1 mice

NASA Astrophysics Data System (ADS)

Raber, Jacob; Marzulla, Tessa; Kronenberg, Amy; Turker, Mitchell S.

2015-11-01

The space radiation environment includes energetic charged particles that may impact cognitive performance. We assessed the effects of 16O ion irradiation on cognitive performance of C57BL/6J × DBA/2J F1 (B6D2F1) mice at OHSU (Portland, OR) one month following irradiation at Brookhaven National Laboratory (BNL, Upton, NY). Hippocampus-dependent contextual fear memory and hippocampus-independent cued fear memory of B6D2F1 mice were tested. 16O ion exposure enhanced cued fear memory. This effect showed a bell-shaped dose response curve. Cued fear memory was significantly stronger in mice irradiated with 16O ions at a dose of 0.4 or 0.8 Gy than in sham-irradiated mice or following irradiation at 1.6 Gy. In contrast to cued fear memory, contextual fear memory was not affected following 16O ion irradiation at the doses used in this study. These data indicate that the amygdala might be particularly susceptible to effects of 16O ion exposure.

Cordycepin (3'-deoxyadenosine) inhibits the growth of B16-BL6 mouse melanoma cells through the stimulation of adenosine A3 receptor followed by glycogen synthase kinase-3beta activation and cyclin D1 suppression.

PubMed

Yoshikawa, Noriko; Yamada, Shizuo; Takeuchi, Chihiro; Kagota, Satomi; Shinozuka, Kazumasa; Kunitomo, Masaru; Nakamura, Kazuki

2008-06-01

Cordyceps sinensis, a parasitic fungus on the larvae of Lepidoptera, has been used as a traditional Chinese medicine. We previously reported that the growth of B16-BL6 mouse melanoma (B16-BL6) cells was inhibited by cordycepin (3'-deoxyadenosine), an active ingredient of C. sinensis, and its effect was antagonized by MRS1191, a selective adenosine A3 receptor antagonist. In this study, the radioligand binding assay using [125I]-AB-MECA (a selective adenosine A3 receptor agonist) has shown that B16-BL6 cells express adenosine A3 receptors and that cordycepin binds to these receptors. We also confirmed the involvement of adenosine A3 receptors in the action of cordycepin using MRS1523 and MRS1220, specific adenosine A3 receptor antagonists. Next, indirubin, a glycogen synthase kinase-3beta (GSK-3beta) inhibitor, antagonized the growth suppression induced by cordycepin. Furthermore, the level of cyclin D1 protein in B16-BL6 cells was decreased by cordycepin using Western blot analysis. In conclusion, this study demonstrated that cordycepin inhibits the proliferation of B16-BL6 cells by stimulating adenosine A3 receptors followed by the Wnt signaling pathway, including GSK-3beta activation and cyclin D1 inhibition.

Sensor Technology Assessment for Ordnance and Explosive Waste Detection and Location. Revision B.

DTIC Science & Technology

1995-03-01

5 Figure 1.5 Examples Of Anti-Tank Mines .................... .................... 5 Figure 1.6. Sample Drawing of a Bomb...6 Figure 1.7. Examples of Scatterable Anti-Personnel Mines (top) and Scatterable Anti-Tank Mines (bottom...individuals, and therefore the OEW items must be detected and located. OEW examples are bombs, warheads, guided missiles, mortars, small arms, mines

A 30-GHz monolithic receiver

NASA Technical Reports Server (NTRS)

Liu, Louis C. T.; Liu, Carol S.; Kessler, Joel R.; Wang, Shing-Kuo; Chang, Ching-Der

1986-01-01

Several monolithic integrated circuits have been developed to make a 30-GHz receiver. The receiver components include a low-noise amplifier (LNA), an IF amplifier, a mixer, and a phase shifter. The LNA has a 7-dB noise figure with over 17 dB of associated gain. The IF amplifier has a 13-dB gain with a 30-dB control range. The mixer has a conversion loss of 10.5 dB. The phase shifter has a 180-deg phase shift control and a minimum insertion loss of 1.6 dB.

Word Frequency Analysis. MOS: 12B. Skill Levels 1 & 2.

DTIC Science & Technology

1981-05-01

2 BURNING 16 RURNS 1 9 BJRRS- I BUP $I-ON-TARGET 9 5UJR STE R 2 RP ES I PIG PU 1 UR S11 N-TVPE...TV f 37 SHJFT ?7 STAKES 37 SUPPORT 37 SITMM 36 ADJUSTMrNT ?b.. 36 ATTACII 36- BEING .... 36 P . .. It# OIKP TIfOt 36 EXPOSED 36 IAW 16 I NSTRUICT IONS...APPENDIX lb ARTIFICIAL 16 ASSEPRLED . 6 ASLFC 16 BREAK 16 BREECH 16 BURNS 16 CA D 16 CLEARED --- to ELcCERISr- - --- -CVRT ( lb -UUI(OT ONNECTCR 1b

Combination of amino acids reduces pigmentation in B16F0 melanoma cells.

PubMed

Ishikawa, Masago; Kawase, Ichiro; Ishii, Fumio

2007-04-01

Amino acids, the building blocks of proteins, play significant roles in numerous physiological events in mammals. As the effects of amino acids on melanogenesis have yet to be demonstrated, the present study was conducted to identify whether amino acids, in particular alanine, glycine, isoleucine and leucine, influence melanogenesis in B16F0 melanoma cells. Glycine and L-isoleucine, but not D-isoleucine, reduced melanogenesis in a concentration-dependent manner without any morphological changes in B16F0 melanoma cells. L-Alanine and L-leucine, but not D-alanine and D-leucine, also reduced melanogenesis without any morphological changes in B16F0 melanoma cells. However these amino acids did not show a concentration-dependency. Combination of L-alanine and the other amino acids, particularly 4 amino acids combination, had an additive effect on the inhibition of melanogenesis compared with single treatment of L-alanine. None of the amino acids affected the activity of tyrosinase, a key enzyme in melanogenesis. These results suggest that L-alanine, glycine, L-isoleucine and L-leucine, but not the D-form amino acids, have a hypopigmenting effect in B16F0 melanoma cells, and that these effects are not due to the inhibition of tyrosinase activity. Combination of these 4 amino acids had the additive effect on hypopigmentation that was as similar as that of kojic acid.

Power Mems Development

DTIC Science & Technology

2010-11-30

testing and analysis in ONR laboratories. Task 1.2 Contributors: Sunny Kedia, Shinzo Onishi , Scott Samson, Drew Hanser Task 1.2 Deliverable...Priscila Spagnol, Shinzo Onishi , Drew Hanser, Weidong Wang, Sunny Kedia, John Bumgarner Deliverable: Prototype device fabricated on a thin-film diamond

Power Mems Development

DTIC Science & Technology

2010-12-31

laboratories. Task 1.2 Contributors: Sunny Kedia, Shinzo Onishi , Scott Samson, Drew Hanser Task 1.2 Deliverable: Functional MEMS-based DC-DC...Shinzo Onishi , Drew Hanser, Weidong Wang, Sunny Kedia, John Bumgarner Deliverable: Prototype device fabricated on a thin-film diamond heat spreader

Beam commissioning and measurements validating the beam model in a new TPS that converts helical tomotherapy plans to step-and-shoot IMRT plans.

PubMed

Petersson, Kristoffer; Ceberg, Crister; Engström, Per; Knöös, Tommy

2011-01-01

A new type of treatment planning system called SHAREPLAN has been studied, which enables the transfer of treatment plans generated for helical tomotherapy delivery to plans that can be delivered on C-arm linacs. The purpose is to ensure continuous patient treatment during periods of unscheduled downtime for the TomoTherapy unit, particularly in clinics without a backup unit. The purpose of this work was to verify that the plans generated in this novel planning system are deliverable and accurate. The work consists primarily of beam commissioning, verification of the beam model, and measurements verifying that generated plans are deliverable with sufficient accuracy. The beam commissioning process involves input of general geometric properties of the modeled linac, profiles and depth dose curves for a specific photon nominal energy (6 MV), and the automated modeling of other beam properties. Some manual tuning of the beam model is required. To evaluate its accuracy, the confidence limit concept [J. Venselaar et al., "Tolerances for the accuracy of photon beam dose calculations of treatment planning systems," Radiother. Oncol. 60, 191-201 (2001)] was used, which is a method supported by ESTRO. Measurements were conducted with a 2D diode array at the commissioned linac as a final check of the beam model and to evaluate whether the generated plans were deliverable and accurate. The comparison and evaluation of calculated data points and measured data according to the method applied confirmed the accuracy of the beam model. The profiles had a confidence limit of 1.1% and the depth dose curves had a confidence limit of 1.7%, both of which were well below the tolerance limit of 2%. Plan specific QC measurements and evaluation verified that different plans generated in the TPS were deliverable with sufficient accuracy at the commissioned linac, as none of the 160 beams for the 20 different plans evaluated had a fraction of approved data points below 90%, the local clinical approval criterion for delivery QA measurements. This study is a validation of the new TPS as it verifies that the generated plans are deliverable at a commissioned linac with adequate accuracy. A thorough investigation of the treatment plan quality will require a separate study. The TPS is proving to be a useful and time-saving complement, especially for clinics having a single unit for helical delivery among its conventional linacs.

16 × 16 non-blocking silicon optical switch based on electro-optic Mach-Zehnder interferometers.

PubMed

Lu, Liangjun; Zhao, Shuoyi; Zhou, Linjie; Li, Dong; Li, Zuxiang; Wang, Minjuan; Li, Xinwan; Chen, Jianping

2016-05-02

We experimentally demonstrate a 16 × 16 non-blocking optical switch fabric with a footprint of 10.7 × 4.4 mm². The switch fabric is composed of 56 2 × 2 silicon Mach-Zehnder interferometers (MZIs), with each integrated with a pair of TiN resistive micro-heaters and a p-i-n diode. The average on-chip insertion loss at 1560 nm wavelength is ~6.7 dB and ~14 dB for the "all-cross" and "all-bar" states, respectively, with a loss variation of ± 1 dB over all routing paths. The measured rise/fall time of the switch upon electrical tuning is 3.2/2.5 ns. The switching functionality is verified by transmission of 20 Gb/s on-off keying (OOK) and 50 Gb/s quadrature phase-shift keying (QPSK) optical signals.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Temple, Brian Allen; Armstrong, Jerawan Chudoung

This document is a mid-year report on a deliverable for the PYTHON Radiography Analysis Tool (PyRAT) for project LANL12-RS-107J in FY15. The deliverable is deliverable number 2 in the work package and is titled “Add the ability to read in more types of image file formats in PyRAT”. Right now PyRAT can only read in uncompressed TIF files (tiff files). It is planned to expand the file formats that can be read by PyRAT, making it easier to use in more situations. A summary of the file formats added include jpeg, jpg, png and formatted ASCII files.

Transuranic Waste Program Framework Agreement - December Deliverable July 2012

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jones, Patricia

Framework agreement deliverables are: (1) 'DOE/NNSA commits to complete removal of all non-cemented above-ground EM Legacy TRU and newly generated TRU currently-stored at Area G as of October 1, 2011, by no later than June 30, 2014. This inventory of above-ground TRU is defined as 3706 cubic meters of material.' (2) 'DOE commits to the complete removal of all newly generated TRU received in Area G during FY 2012 and 2013 by no later than December 31, 2014.' (3) 'Based on projected funding profiles, DOE/NNSA will develop by December 31, 2012, a schedule, including pacing milestones, for disposition of themore » below-ground TRU requiring retrieval at Area G.' Objectives are to: (1) restore the 'Core Team' to develop the December, 2012 deliverable; (2) obtain agreement on the strategy for below ground water disposition; and (3) establish timeline for completion of the deliverable. Below Grade Waste Strategy is to: (1) Perform an evaluation on below grade waste currently considered retrievable TRU; (2) Only commit to retrieve waste that must be retrieved; (3) Develop the Deliverable including Pacing Milestones based on planned commitments; (4) Align all Regulatory Documents for Consistency; and (5) answer these 3 primary questions, is the waste TRU; is the waste retrievable, can retrieval cause more harm than benefit?« less

Feasibility of Nanoparticle-Guided Radiation Therapy (NGRT) Using a Conventional CT Scanner

DTIC Science & Technology

2010-10-01

deliverability of plan on CT scanner 2c. Calibrate dosimeters ( TLDs ) in phantom material 2d. Deliver dose distribution to phantom with TLDs in...phantom (SOW 2a). Next, small thermoluminescent dosimeters ( TLDs ) are placed within the tumor cavity. The TLDs are irradiated both with and without...nuclear data files. Electron interaction data is taken from the RSICC-EL03 library. The tumor volume was simulated as a small cavity containing

A Dual-Layer Transducer Array for 3-D Rectilinear Imaging

PubMed Central

Yen, Jesse T.; Seo, Chi Hyung; Awad, Samer I.; Jeong, Jong S.

2010-01-01

2-D arrays for 3-D rectilinear imaging require very large element counts (16,000–65,000). The difficulties in fabricating and interconnecting 2-D arrays with a large number of elements (>5,000) have limited the development of suitable transducers for 3-D rectilinear imaging. In this paper, we propose an alternative solution to this problem by using a dual-layer transducer array design. This design consists of two perpendicular 1-D arrays for clinical 3-D imaging of targets near the transducer. These targets include the breast, carotid artery, and musculoskeletal system. This transducer design reduces the fabrication complexity and the channel count making 3-D rectilinear imaging more realizable. With this design, an effective N × N 2-D array can be developed using only N transmitters and N receivers. This benefit becomes very significant when N becomes greater than 128, for example. To demonstrate feasibility, we constructed a 4 × 4 cm prototype dual-layer array. The transmit array uses diced PZT-5H elements, and the receive array is a single sheet of undiced P[VDF-TrFE] copolymer. The receive elements are defined by the copper traces on the flexible interconnect circuit. The measured −6 dB fractional bandwidth was 80% with a center frequency of 4.8 MHz. At 5 MHz, the nearest neighbor crosstalk of the PZT array and PVDF array was −30.4 ± 3.1 dB and −28.8 ± 3.7 dB respectively. This dual-layer transducer was interfaced with an Ultrasonix Sonix RP system, and a synthetic aperture 3-D data set was acquired. We then performed off-line 3-D beamforming to obtain volumes of nylon wire targets. The theoretical lateral beamwidth was 0.52 mm compared to measured beamwidths of 0.65 mm and 0.67 mm in azimuth and elevation respectively. 3-D images of an 8 mm diameter anechoic cyst phantom were also acquired. PMID:19213647

Transfer Learning in Integrated Cognitive Systems

DTIC Science & Technology

2010-09-01

Psychology Press. 2. Falkenhainer, B ., Forbus, K . D., and Gentner, D. (1989). The Structure-mapping Engine: Algorithm and Examples. Artificial...Kaps, A.; Lemcke, K .; Mannhaupt, G.; Pfeiffer, F.; Schuller, C.; Stocker, S. & Weil, B ., "MIPS: A Database for Genomes and Protein Sequences...NAME OF RESPONSIBLE PERSON Deborah A. Cerino a. REPORT U b . ABSTRACT U c. THIS PAGE U 19b. TELEPHONE NUMBER (Include area code) N/A

Comparative immunogenicity and safety of human papillomavirus (HPV)-16/18 AS04-adjuvanted vaccine and HPV-6/11/16/18 vaccine administered according to 2- and 3-dose schedules in girls aged 9–14 years: Results to month 12 from a randomized trial

PubMed Central

Leung, Ting Fan; Liu, Anthony Pak-Yin; Lim, Fong Seng; Thollot, Franck; Oh, Helen May Lin; Lee, Bee Wah; Rombo, Lars; Tan, Ngiap Chuan; Rouzier, Roman; Friel, Damien; De Muynck, Benoit; De Simoni, Stéphanie; Suryakiran, Pemmaraju; Hezareh, Marjan; Folschweiller, Nicolas; Thomas, Florence; Struyf, Frank

2015-01-01

This observer-blind study (clinicaltrials.gov NCT01462357) compared the immunogenicity and safety of 2 doses of the HPV-16/18 AS04-adjuvanted vaccine (HPV-16/18(2D)) vs. 2 or 3 doses of the HPV-6/11/16/18 vaccine (HPV-6/11/16/18(2D) and HPV-6/11/16/18(3D)) in healthy girls aged 9–14 y. Girls were randomized (1:1:1) to receive HPV-16/18(2D) at months (M) 0,6 (N = 359), HPV-6/11/16/18(2D) at M0,6 (N = 358) or HPV-6/11/16/18(3D) at M0,2,6 (N = 358). The primary objective was non-inferiority/superiority of HPV-16/18 antibodies by ELISA for HPV-16/18(2D) vs. HPV-6/11/16/18(2D) at M7 in the according-to-protocol immunogenicity cohort (ATP-I) and total vaccinated cohort, respectively. Secondary objectives included non-inferiority/superiority of HPV-16/18(2D) vs. HPV-6/11/16/18(3D) at M7, non-inferiority/superiority at M12, HPV-16/18 neutralizing antibodies, frequencies of T-cells/B-cells, reactogenicity and safety. Antibody responses at M7 for HPV-16/18(2D) were superior to those for HPV-6/11/16/18(2D) and HPV-6/11/16/18(3D) (lower limit of 95% confidence interval for geometric mean titer ratio (GMR) was >1): HPV-16/18(2D)/HPV-6/11/16/18(2D) GMRs were 1.69 [1.49–1.91] for anti-HPV-16 and 4.52 [3.97–5.13] for anti-HPV-18; HPV-16/18(2D)/HPV-6/11/16/18(3D) GMRs were 1.72 [1.54–1.93] for anti-HPV-16 and 3.22 [2.82–3.68] for anti-HPV-18; p = 0.0001 for all comparisons. Non-inferiority/superiority was also demonstrated at M12. Among initially seronegative girls in the ATP-I, neutralizing antibody titers were at least 1.8-fold higher for HPV-16/18(2D) vs. HPV-6/11/16/18(2D) and HPV-6/11/16/18(3D) at M7 and M12. Frequencies of HPV-16/18-specific T-cells and B-cells were in similar ranges between groups. Reactogenicity and safety were in line with the known profile of each vaccine. In conclusion, superior HPV-16/18 antibody responses were elicited by 2 doses of the HPV-16/18 AS04-adjuvanted vaccine compared with 2 or 3 doses of the HPV-6/11/16/18 vaccine in girls (9–14 years). PMID:26062002

Cost and Schedule Analytical Techniques Development: Option 2 Year

NASA Technical Reports Server (NTRS)

1997-01-01

This Final Report summarizes the activities performed by Science Applications International Corporation (SAIC) for the Option 2 Year from December 1, 1996 through November 30, 1997. The Final Report is in compliance with Paragraph 5 of Section F of the contract. This CSATD contract provides products and deliverable in the form of models, data bases, methodologies, studies and analyses for the NASA Marshall Space Flight Center's (MSFC) Engineering Cost Office (PPO3) the Program Plans and Requirements Officer (PP02), and other user organizations. Detailed Monthly Progress reports were submitted to MSFC in accordance with the contract's Statement of Work, Section TV "Reporting and Documentation". These reports spelled out each month's specific work accomplishments, deliverables submitted, major meetings held, and other pertinent information. This Final Report will summarize these activities at higher level. During this contract Option Year, SAIC expended 29,830 man-hours in tile performance of tasks called out in the Statement of Work and reported oil in this yearly Final Report. This represents approximately 16 full-time EPs. Included are the basis Huntsville-based team, plus SAIC specialists in San Diego, Ames Research Center, Chicago, and Colorado Springs performing specific tasks for which they are uniquely qualified.

Group 16SrXI phytoplasma strains, including subgroup 16SrXI-B and a new subgroup, 16SrXI-D, are associated with sugar cane white leaf.

PubMed

Zhang, Rong-Yue; Li, Wen-Feng; Huang, Ying-Kun; Wang, Xiao-Yan; Shan, Hong-Li; Luo, Zhi-Ming; Yin, Jiong

2016-01-01

Sugar cane white leaf (SCWL) is a serious disease caused by phytoplasmas. In this study, we performed nested PCR with phytoplasma universal primer pairs (P1/P7 and R16F2n/R16R2) for the 16S rRNA gene to detect SCWL phytoplasmas in 31 SCWL samples collected from Baoshan and Lincang, Yunnan, China. We cloned and sequenced the nested PCR products, revealing that the 16S rRNA gene sequences from 31 SCWL samples were all 1247 bp in length and shared more than 99 % nucleotide sequence similarity with the 16S rRNA gene sequences of SCWL phytoplasmas from various countries. Based on the reported 16S rRNA gene sequence data from SCWL isolates of various countries, we conducted phylogenetic and virtual RFLP analysis. In the resulting phylogenetic tree, all SCWL isolates clustered into two branches, with the Lincang and Baoshan SCWL phytoplasma isolates belonging to different branches. The virtual RFLP patterns show that phytoplasmas of the Lincang branch belong to subgroup 16SrXI-B. However, the virtual RFLP patterns revealed by HaeIII digestion of phytoplasmas of the Baoshan branch differed from those of subgroup 16SrXI-B. According to the results of phylogenetic and virtual RFLP analysis, we propose that the phytoplasmas of the Baoshan branch represent a new subgroup, 16SrXI-D. These findings suggest that SCWL is caused by phytoplasmas from group 16SrXI, including subgroup 16SrXI-B and a new subgroup, 16SrXI-D.

Michales AAF, Dugway, Utah. Revised Uniform Summary of Surface Weather Observations (RUSSWO). Parts A - F

DTIC Science & Technology

1974-03-21

We, Boi Do. o 90/ 89 . -- -- - -A lt eI -- ... .. -- .- -"a___ ..... J __v a L_:I 4 4.56/ 81 Io 1 31 . I- ,5"z l .2 6 26 ,_. __ll5 , , ._. .3 1 2...30 31 D.B./W.B. v),, 00,16W., d.16s Des Porn , " ,.b/ 15 I _..- -i7 12/1- - - r- - - t . .... -9 1 6 I’ TOTAL . 2. . . . ... .... -55 1. .9 .2 .1...3. 4f . { . 14. 1015 1S~6 17 - 18119.- 20 21,-22123.2- 2 8 9 30 j1D.B.’W.B. Dry Bulb] Wt 6u.b6[5-a Porn ’ 60/ 59 - Iti!I I-./’ ’ ’ ’ ’ t- - " 5 1

40 CFR 81.275 - Lake Tahoe Intrastate Air Quality Control Region.

Code of Federal Regulations, 2010 CFR

2010-07-01

...: commencing at the point common to the aforementioned drainage area crestline and the line common to Townships... westerly direction to the northwest corner of Section 3, Township 15 North, Range 16 East, M.D.B. & M., thence south along the west line of Sections 3 and 10, Township 15 North, Range 16 East, M.D.B. & M., to...

40 CFR 81.274 - Mountain Counties Intrastate Air Quality Control Region.

Code of Federal Regulations, 2011 CFR

2011-07-01

... point common to the aforementioned drainage area crestline and the line common to Townships 15 North and... direction to the northwest corner of Section 3, Township 15 North, Range 16 East, M.D.B. & M., thence south along the west line of Sections 3 and 10, Township 15 North, Range 16 East, M.D.B. & M., to the...

40 CFR 81.275 - Lake Tahoe Intrastate Air Quality Control Region.

Code of Federal Regulations, 2011 CFR

2011-07-01

...: commencing at the point common to the aforementioned drainage area crestline and the line common to Townships... westerly direction to the northwest corner of Section 3, Township 15 North, Range 16 East, M.D.B. & M., thence south along the west line of Sections 3 and 10, Township 15 North, Range 16 East, M.D.B. & M., to...

40 CFR 81.274 - Mountain Counties Intrastate Air Quality Control Region.

Code of Federal Regulations, 2010 CFR

2010-07-01

... point common to the aforementioned drainage area crestline and the line common to Townships 15 North and... direction to the northwest corner of Section 3, Township 15 North, Range 16 East, M.D.B. & M., thence south along the west line of Sections 3 and 10, Township 15 North, Range 16 East, M.D.B. & M., to the...

Finite Element Development and Specifications of a Patched, Recessed Nomex Core Honeycomb Panel for Increased Sound Transmission Loss

NASA Technical Reports Server (NTRS)

Grosveld, Ferdinand W.

2007-01-01

This informal report summarizes the development and the design specifications of a recessed nomex core honeycomb panel in fulfillment of the deliverable in Task Order 13RBE, Revision 10, Subtask 17. The honeycomb panel, with 0.020-inch thick aluminum face sheets, has 0.016-inch thick aluminum patches applied to twenty-five, 6 by 6 inch, quarter inch thick recessed cores. A 10 dB higher transmission loss over the frequency range 250 - 1000 Hz was predicted by a MSC/NASTRAN finite element model when compared with the transmission loss of the base nomex core honeycomb panel. The static displacement, due to a unit force applied at either the core or recessed core area, was of the same order of magnitude as the static displacement of the base honeycomb panel when exposed to the same unit force. The mass of the new honeycomb design is 5.1% more than the base honeycomb panel. A physical model was constructed and is being tested.

Anisotropic Grid Generation

DTIC Science & Technology

2016-03-24

AFRL-AFOSR-VA-TR-2016-0129 ANISOTROPIC GRID GENERATION | Deliverables Daniel Sievenpiper UNIVERSITY OF CALIFORNIA SAN DIEGO Final Report 03/24/2016...ORGANIZATION. 1. REPORT DATE (DD-MM-YYYY) 12-03-2016 2 . REPORT TYPE Final report 3. DATES COVERED (From - To) 15-12-2012 - 14-12-2015 4. TITLE AND...SUBTITLE Anisotropic Grid Generation 5a. CONTRACT NUMBER 5b. GRANT NUMBER FA9550-13-1-0014 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) Daniel

Modular Towed Acoustic Sonar Array

DTIC Science & Technology

2014-02-04

Dkt . No...d 11 5 11 0c 11 0d 11 5 14 0 16 0’ 1 60 ’’ 12 0 14 0 12 0 14 0 13 0 14 0 12 0 13 0 12 0 12 0 13 0 14 0 16 0 10 0 d 2 d 3 Dkt . No. 102060 Application...of Non-Acoustic Sensors in Second Sensor Array Dkt . No. 102060 Application No. ?? REPLACEMENT SHEET? /3 1st DRAFT 3 F IG . 3 11 5 16 4 16 8 16 2 16 6 11 5 1 50 11 0b 18 0 17 0 16 6a 16 4a 18 0 10 0 11 0a 15 0

Synthesis of Norbornane Bisether Antibiotics via Silver-mediated Alkylation

PubMed Central

Hickey, Shane M.; Ashton, Trent D.; White, Jonathan M.; Li, Jian; Nation, Roger L.; Yu, Heidi Y.; Elliott, Alysha G.; Butler, Mark S.; Huang, Johnny X.; Cooper, Matthew A.

2015-01-01

A small series of norbornane bisether diguanidines have been synthesized and evaluated as antibacterial agents. The key transformation—bisalkylation of norbornane diol 6—was not successful using Williamson methodology but has been accomplished using Ag2O mediated alkylation. Further functionalization to incorporate two guanidinium groups gave rise to a series of structurally rigid cationic amphiphiles; several of which (16d, 16g and 16h) exhibited antibiotic activity. For example, compound 16d was active against a broad range of bacteria including Pseudomonas aeruginosa (MIC = 8 µg/mL), Escherichia coli (MIC = 8 µg/mL) and methicillin-resistant Staphylococcus aureus (MIC = 8 µg/mL). PMID:26251697

Microstructure Evolution During Warm Working of Ti-6Al-4V with a Colony Alpha Microstructure (Preprint)

DTIC Science & Technology

2008-09-01

6 maps such as those shown in Fig. 4 ; typical examples of the cumulative misorientation are given in Figs. 5 and 6 , respectively...misorientation line scans shown in Figs. 5 and 6 . Fig. 5. Typical line scans from EBSD maps in Fig. 4 showing the variation of orientation over a long...e g 0 2 4 6 8 10 12 14 16 (b) Distance, μm 0 20 40 60 80 100 C u m u l a t i v e m i s o r i e n t a t i o n , d e g 0 5 10 15

Computational discovery of metal-organic frameworks with high gas deliverable capacity

NASA Astrophysics Data System (ADS)

Bao, Yi

Metal-organic frameworks (MOFs) are a rapidly emerging class of nanoporous materials with largely tunable chemistry and diverse applications in gas storage, gas purification, catalysis, sensing and drug delivery. Efforts have been made to develop new MOFs with desirable properties both experimentally and computationally for decades. To guide experimental synthesis, we here develop a computational methodology to explore MOFs with high gas deliverable capacity. This de novo design procedure applies known chemical reactions, considers synthesizability and geometric requirements of organic linkers, and efficiently evolves a population of MOFs to optimize a desirable property. We identify 48 MOFs with higher methane deliverable capacity at 65-5.8 bar condition than the MOF-5 reference in nine networks. In a more comprehensive work, we predict two sets of MOFs with high methane deliverable capacity at a 65-5.8 bar loading-delivery condition or a 35-5.8 bar loading-delivery condition. We also optimize a set of MOFs with high methane accessible internal surface area to investigate the relationship between deliverable capacities and internal surface area. This methodology can be extended to MOFs with multiple types of linkers and multiple SBUs. Flexibile MOFs may allow for sophisticated heat management strategies and also provide higher gas deliverable capacity than rigid frameworks. We investigate flexible MOFs, such as MIL-53 families, and Fe(bdp) and Co(bdp) analogs, to understand the structural phase transition of frameworks and the resulting influence on heat of adsorption. Challenges of simulating a system with a flexible host structure and incoming guest molecules are discussed. Preliminary results from isotherm simulation using the hybrid MC/MD simulation scheme on MIL-53(Cr) are presented. Suggestions for proceeding to understand the free energy profile of flexible MOFs are provided.

Lost in the supermarket: Quantifying the cost of partitioning memory sets in hybrid search.

PubMed

Boettcher, Sage E P; Drew, Trafton; Wolfe, Jeremy M

2018-01-01

The items on a memorized grocery list are not relevant in every aisle; for example, it is useless to search for the cabbage in the cereal aisle. It might be beneficial if one could mentally partition the list so only the relevant subset was active, so that vegetables would be activated in the produce section. In four experiments, we explored observers' abilities to partition memory searches. For example, if observers held 16 items in memory, but only eight of the items were relevant, would response times resemble a search through eight or 16 items? In Experiments 1a and 1b, observers were not faster for the partition set; however, they suffered relatively small deficits when "lures" (items from the irrelevant subset) were presented, indicating that they were aware of the partition. In Experiment 2 the partitions were based on semantic distinctions, and again, observers were unable to restrict search to the relevant items. In Experiments 3a and 3b, observers attempted to remove items from the list one trial at a time but did not speed up over the course of a block, indicating that they also could not limit their memory searches. Finally, Experiments 4a, 4b, 4c, and 4d showed that observers were able to limit their memory searches when a subset was relevant for a run of trials. Overall, observers appear to be unable or unwilling to partition memory sets from trial to trial, yet they are capable of restricting search to a memory subset that remains relevant for several trials. This pattern is consistent with a cost to switching between currently relevant memory items.

A computational study of the dechlorination of β-hexachlorocyclohexane (β-HCH) catalyzed by the haloalkane dehalogenase LinB.

PubMed

Manna, Rabindra Nath; Dybala-Defratyka, Agnieszka

2014-11-15

LinB, a haloalkane dehalogenase from Sphingomonas paucimobilis UT26, is known to metabolize halohydrocarbons to halide ions and the respective alcohols. Its broad substrate specificity allowed its consideration for bioremediation. Herein, we have shown its catalytic action toward β-hexachlorocyclohexane (β-HCH) - an example of large-size substrates that can be accommodated in its active site. We have analyzed the capability of combined QM/MM schemes to describe in detail the SN2 dechlorination reaction between β-HCH and Asp108 in the active site of LinB. Free energy surfaces have been calculated using one and two dimensional potentials of mean force (PMF) obtained at the PM3/MM (MM=amberff99SB, TIP3P) level of theory. The overestimated energetic barriers by the PM3 Hamiltonian were corrected using a DFT functional (M06-2X). The resulted activation energies (16 and 19 kcal mol(-1) from 1D and 2D-PMF profiles, respectively) for the dechlorination reaction of β-HCH in the active site of LinB enzyme are in qualitative agreement with the experimentally determined value of 17 kcal mol(-1). The binding of β-HCH to the active site of LinB has been compared to the binding of smaller 1-chlorobutane (1-CB) and larger δ-hexabromocyclododecane (δ-HBCD). Copyright © 2014 Elsevier Inc. All rights reserved.

FPGA-based LDPC-coded APSK for optical communication systems.

PubMed

Zou, Ding; Lin, Changyu; Djordjevic, Ivan B

2017-02-20

In this paper, with the aid of mutual information and generalized mutual information (GMI) capacity analyses, it is shown that the geometrically shaped APSK that mimics an optimal Gaussian distribution with equiprobable signaling together with the corresponding gray-mapping rules can approach the Shannon limit closer than conventional quadrature amplitude modulation (QAM) at certain range of FEC overhead for both 16-APSK and 64-APSK. The field programmable gate array (FPGA) based LDPC-coded APSK emulation is conducted on block interleaver-based and bit interleaver-based systems; the results verify a significant improvement in hardware efficient bit interleaver-based systems. In bit interleaver-based emulation, the LDPC-coded 64-APSK outperforms 64-QAM, in terms of symbol signal-to-noise ratio (SNR), by 0.1 dB, 0.2 dB, and 0.3 dB at spectral efficiencies of 4.8, 4.5, and 4.2 b/s/Hz, respectively. It is found by emulation that LDPC-coded 64-APSK for spectral efficiencies of 4.8, 4.5, and 4.2 b/s/Hz is 1.6 dB, 1.7 dB, and 2.2 dB away from the GMI capacity.

COMPONENT-BASED AND WHOLE-MIXTURE ASSESSMENTS IN ADDRESSING THE UNIDENTIFIED FRACTION OF COMPLEX MIXTURES: DRINKING WATER AS AN EXAMPLE

EPA Science Inventory

Component-Based and Whole-Mixtures Assessments in Addressing the Unidentified Fraction of Complex Mixtures: Drinking Water as an Example

J. E. Simmons; L. K. Teuschler; C. Gennings; T. F. Speth; S. D. Richardson; R. J. Miltner; M. G. Narotsky; K. D. Schenck; G. Rice

Resonating group method as applied to the spectroscopy of α-transfer reactions

NASA Astrophysics Data System (ADS)

Subbotin, V. B.; Semjonov, V. M.; Gridnev, K. A.; Hefter, E. F.

1983-10-01

In the conventional approach to α-transfer reactions the finite- and/or zero-range distorted-wave Born approximation is used in liaison with a macroscopic description of the captured α particle in the residual nucleus. Here the specific example of 16O(6Li,d)20Ne reactions at different projectile energies is taken to present a microscopic resonating group method analysis of the α particle in the final nucleus (for the reaction part the simple zero-range distorted-wave Born approximation is employed). In the discussion of suitable nucleon-nucleon interactions, force number one of the effective interactions presented by Volkov is shown to be most appropriate for the system considered. Application of the continuous analog of Newton's method to the evaluation of the resonating group method equations yields an increased accuracy with respect to traditional methods. The resonating group method description induces only minor changes in the structures of the angular distributions, but it does serve its purpose in yielding reliable and consistent spectroscopic information. NUCLEAR STRUCTURE 16O(6Li,d)20Ne; E=20 to 32 MeV; calculated B(E2); reduced widths, dσdΩ extracted α-spectroscopic factors. ZRDWBA with microscope RGM description of residual α particle in 20Ne; application of continuous analog of Newton's method; tested and applied Volkov force No. 1; direct mechanism.

Guidance for improving foundation layers to increase pavement performance on local roads.

DOT National Transportation Integrated Search

2014-11-01

This document is the second of two deliverables for the project Optimizing Pavement Base, Subbase, and Subgrade Layers : for Cost and Performance on Local Roads (TR-640). The first deliverable is the 454-page Final Field Data Report. The field : data...

Long-term vegetation monitoring in Great Britain - the Countryside Survey 1978-2007 and beyond

NASA Astrophysics Data System (ADS)

Wood, Claire M.; Smart, Simon M.; Bunce, Robert G. H.; Norton, Lisa R.; Maskell, Lindsay C.; Howard, David C.; Scott, W. Andrew; Henrys, Peter A.

2017-07-01

The Countryside Survey (CS) of Great Britain provides a globally unique series of datasets, consisting of an extensive set of repeated ecological measurements at a national scale, covering a time span of 29 years. CS was first undertaken in 1978 to monitor ecological and land use change in Britain using standardised procedures for recording ecological data from representative 1 km squares throughout the country. The same sites, with some additional squares, were used for subsequent surveys of vegetation undertaken in 1990, 1998 and 2007, with the intention of future surveys. Other data records include soils, freshwater habitats and invertebrates, and land cover and landscape feature diversity and extents. These data have been recorded in the same locations on analogous dates. However, the present paper describes only the details of the vegetation surveys. The survey design is a series of gridded, stratified, randomly selected 1 km squares taken as representative of classes derived from a statistical environmental classification of Britain. In the 1978 survey, 256 one-kilometre sample squares were recorded, increasing to 506 in 1990, 569 in 1998 and 591 in 2007. Initially each square contained up to 11 dispersed vegetation plots but additional plots were later placed in different features so that eventually up to 36 additional sampling plots were recorded, all of which can be relocated where possible (unless the plot has been lost, for example as a consequence of building work), providing a total of 16 992 plots by 2007. Plots are estimated to have a precise relocation accuracy of 85 %. A range of plots located in different land cover types and landscape features (for example, field boundaries) are included. Although a range of analyses have already been carried out, with changes in the vegetation being related to a range of drivers at local and national scales, there is major potential for further analyses, for example in relation to climate change. Although the precise locations of the plots are restricted, largely for reasons of landowner confidentiality, sample sites are intended to be representative of larger areas, and many potential opportunities for further analyses remain. Data from each of the survey years (1978, 1990, 1998, 2007) are available via the following DOIs: Countryside Survey 1978 vegetation plot data (https://doi.org/10.5285/67bbfabb-d981-4ced-b7e7-225205de9c96), Countryside Survey 1990 vegetation plot data (https://doi.org/10.5285/26e79792-5ffc-4116-9ac7-72193dd7f191), Countryside Survey 1998 vegetation plot data (https://doi.org/10.5285/07896bb2-7078-468c-b56d-fb8b41d47065), Countryside Survey 2007 vegetation plot data (https://doi.org/10.5285/57f97915-8ff1-473b-8c77-2564cbd747bc).

Determining the state-of-health of maintenance-free aircraft batteries

DOE Office of Scientific and Technical Information (OSTI.GOV)

Vutetakis, D.G.; Viswanathan, V.V.

1995-07-01

This paper presents an overview of methods to determine the state-of-health of maintenance-free aircraft batteries. The various failure modes of aircraft batteries are discussed, along with methods of detecting failed batteries. Specific examples of detection methods are presented for the F-16, F-18, AV-8B, B-1B, and B-52 aircraft batteries.

SU-F-P-64: The Impact of Plan Complexity Parameters On the Plan Quality and Deliverability of Volumetric Modulated Arc Therapy with Canonical Correlation Analysis

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jin, X; Yi, J; Xie, C

Purpose: To evaluate the impact of complexity indices on the plan quality and deliverability of volumetric modulated arc therapy (VMAT), and to determine the most significant parameters in the generation of an ideal VMAT plan. Methods: A multi-dimensional exploratory statistical method, canonical correlation analysis (CCA) was adopted to study the correlations between VMAT parameters of complexity, quality and deliverability, as well as their contribution weights with 32 two-arc VMAT nasopharyngeal cancer (NPC) patients and 31 one-arc VMAT prostate cancer patients. Results: The MU per arc (MU/Arc) and MU per control point (MU/CP) of NPC were 337.8±25.2 and 3.7±0.3, respectively, whichmore » were significantly lower than those of prostate cancer patients (MU/Arc : 506.9±95.4, MU/CP : 5.6±1.1). The plan complexity indices indicated that two-arc VMAT plans were more complex than one-arc VMAT plans. Plan quality comparison confirmed that one-arc VMAT plans had a high quality than two-arc VMAT plans. CCA results implied that plan complexity parameters were highly correlated with plan quality with the first two canonical correlations of 0.96, 0.88 (both p<0.001) and significantly correlated with deliverability with the first canonical correlation of 0.79 (p<0.001), plan quality and deliverability was also correlated with the first canonical correlation of 0.71 (p=0.02). Complexity parameters of MU/CP, segment area (SA) per CP, percent of MU/CP less 3 and planning target volume (PTV) were weighted heavily in correlation with plan quality and deliveability . Similar results obtained from individual NPC and prostate CCA analysis. Conclusion: Relationship between complexity, quality, and deliverability parameters were investigated with CCA. MU, SA related parameters and PTV volume were found to have strong effect on the plan quality and deliverability. The presented correlation among different quantified parameters could be used to improve the plan quality and the efficiency of the radiotherapy process when creating a complex VMAT plan.« less

SafeLand guidelines for landslide monitoring and early warning systems in Europe - Design and required technology

NASA Astrophysics Data System (ADS)

Bazin, S.

2012-04-01

Landslide monitoring means the comparison of landslide characteristics like areal extent, speed of movement, surface topography and soil humidity from different periods in order to assess landslide activity. An ultimate "universal" methodology for this purpose does not exist; every technology has its own advantages and disadvantages. End-users should carefully consider each one to select the methodologies that represent the best compromise between pros and cons, and are best suited for their needs. Besides monitoring technology, there are many factors governing the choice of an Early Warning System (EWS). A people-centred EWS necessarily comprises five key elements: (1) knowledge of the risks; (2) identification, monitoring, analysis and forecasting of the hazards; (3) operational centre; (4) communication or dissemination of alerts and warnings; and (5) local capabilities to respond to the warnings received. The expression "end-to-end warning system" is also used to emphasize that EWSs need to span all steps from hazard detection through to community response. The aim of the present work is to provide guidelines for establishing the different components for landslide EWSs. One of the main deliverables of the EC-FP7 SafeLand project addresses the technical and practical issues related to monitoring and early warning for landslides, and identifies the best technologies available in the context of both hazard assessment and design of EWSs. This deliverable targets the end-users and aims to facilitate the decision process by providing guidelines. For the purpose of sharing the globally accumulated expertise, a screening study was done on 14 EWSs from 8 different countries. On these bases, the report presents a synoptic view of existing monitoring methodologies and early-warning strategies and their applicability for different landslide types, scales and risk management steps. Several comprehensive checklists and toolboxes are also included to support informed decisions. The deliverable was compiled with contributions from experts on landslides, monitoring technologies, remote sensing, and social researchers from 16 European institutions. The deliverable addresses one of the main objectives of the SafeLand project, namely to merge experience and expert judgment and create synergies on European level towards guidelines for early warning and to make these results available to end-users and local stakeholders.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Misu, Masayasu; Ouji, Yukiteru, E-mail: oujix@naramed-u.ac.jp; Kawai, Norikazu

In spite of the strong expression of Wnt-10b in melanomas, its role in melanoma cells has not been elucidated. In the present study, the biological effects of Wnt-10b on murine B16F10 (B16) melanoma cells were investigated using conditioned medium from Wnt-10b-producing COS cells (Wnt-CM). After 2 days of culture in the presence of Wnt-CM, proliferation of B16 melanoma cells was inhibited, whereas tyrosinase activity was increased. An in vitro wound healing assay demonstrated that migration of melanoma cells to the wound area was inhibited with the addition of Wnt-CM. Furthermore, evaluation of cellular senescence revealed prominent induction of SA-β-gal-positive senescent cellsmore » in cultures with Wnt-CM. Finally, the growth of B16 melanoma cell aggregates in collagen 3D-gel cultures was markedly suppressed in the presence of Wnt-CM. These results suggest that Wnt-10b represses tumor cell properties, such as proliferation and migration of B16 melanoma cells, driving them toward a more differentiated state along a melanocyte lineage. - Highlights: • Wnt-10b inhibited proliferation and migration of melanoma cells. • Wnt-10b induced tyrosinase activity and senescence of melanoma cells. • Wnt-10b suppressed growth of cell aggregates in collagen 3D-gel cultures. • Wnt-10b represses tumor cell properties, driving them toward a more differentiated state along a melanocyte lineage.« less

Re-engineering Cytochrome P450 2B11dH for Enhanced Metabolism of Several Substrates Including the Anti-cancer Prodrugs Cyclophosphamide and Ifosfamide

PubMed Central

Sun, Ling; Chen, Chong S.; Waxman, David J.; Liu, Hong; Halpert, James R.; Kumar, Santosh

2007-01-01

Based on recent directed evolution of P450 2B1, six P450 2B11 mutants at three positions were created in an N-terminal modified construct termed P450 2B11dH and characterized for enzyme catalysis using five substrates. Mutant I209A demonstrated a 3.2-fold enhanced kcat/Km for 7-ethoxy-4-trifluoromethylcourmarin O-deethylation, largely due to a dramatic decrease in Km (0.72 vs. 18 μM). I209A also demonstrated enhanced selectivity for testosterone 16β-hydroxylation over 16α-hydroxylation. In contrast, V183L showed a 4-fold increased kcat for 7-benzyloxyresorufin debenzylation and a 4.7-fold increased kcat/Km for testosterone 16α-hydroxylation. V183L also displayed a 1.7-fold higher kcat/Km than P450 2B11dH with the anti-cancer prodrugs cyclophosphamide and ifosfamide, resulting from a ~4-fold decrease in Km. Introduction of the V183L mutation into full-length P450 2B11 did not enhance the kcat/Km. Overall, the re-engineered P450 2B11dH enzymes exhibited enhanced catalytic efficiency with several substrates including the anti-cancer prodrugs. PMID:17254539

26 CFR 301.6231(d)-1 - Time for determining profits interest of partners for purposes of sections 6223(b) and 6231(a)(11).

Code of Federal Regulations, 2010 CFR

2010-04-01

... examples are as follows: Example 1. B holds an interest in partnership P through T, a pass-thru partner. P... year. As of the close of P's taxable year ending June 30, 2002, T holds an interest in P and B holds an interest in P through T. The profits interest held by B in P through T for that year is determined as of...

The Creative Deliverable: A Short Communication

ERIC Educational Resources Information Center

Hartel, Jenna; Noone, Rebecca; Oh, Christie

2017-01-01

This paper encourages educators in library and information science (LIS) to adopt the "creative deliverable," that is, an assignment that gives students the freedom to display their understanding of course material in an almost unrestricted range of alternative formats and genres, while retaining some key features of traditional…

Interim report deliverable 1.1 : RADAR sensors for transportation applications of the restricted use technology study

DOT National Transportation Integrated Search

2005-09-30

Under Deliverable 1.1 of the Work Plan governing the Altarum Restricted Use Technology Study, the Altarum project team is required to produce an unclassified summary and comprehensive written report of RADAR systems that can potentially address trans...

Interim report deliverable 2.1 : electro-optical sensors for transportation applications of the restricted use technology study

DOT National Transportation Integrated Search

2005-09-30

Under Deliverable 2.1 of the Work Plan governing the Altarum Restricted Use Technology Study, the Altarum project team is required to produce an unclassified summary and comprehensive written report of Electro-Optical (EO) systems that can potentiall...

Efficient glycoengineering of GM3 on melanoma cell and monoclonal antibody-mediated selective killing of the glycoengineered cancer cell

PubMed Central

Wang, Qianli; Zhang, Junping; Guo, Zhongwu

2007-01-01

To verify the principal of a new immunotherapeutic strategy for cancer, a monoclonal antibody 2H3 against N-phenylacetyl GM3, an unnatural form of the tumor-associated antigen GM3, was prepared and employed to demonstrate that murine melanoma cell B16F0 could be effectively glycoengineered by N-phenylacetyl-d-mannosamine to express N-phenylacetyl GM3 and that 2H3 was highly cytotoxic to the glycoengineered B16F0 cell in the presence of complements. It was further demonstrated that B16F0 cell could be glycoengineered 4-5 times more effectively than 3T3 A31 cell, a normal murine embryo fibroblast cell, and that the antibody and complement mediated cytotoxicity was at least 200 times more potent to the glycoengineered B16F0 cell than to the N-phenylacetyl-d-mannosamine-treated 3T3 A31 cell. These results show the promise for developing useful melanoma immunotherapies based on vaccination against N-phenylacetyl GM3 followed by treatment with N-phenylacetyl-d-mannosamine. PMID:17892942

Efficient glycoengineering of GM3 on melanoma cell and monoclonal antibody-mediated selective killing of the glycoengineered cancer cell.

PubMed

Wang, Qianli; Zhang, Junping; Guo, Zhongwu

2007-12-15

To verify the principal of a new immunotherapeutic strategy for cancer, a monoclonal antibody 2H3 against N-phenylacetyl GM3, an unnatural form of the tumor-associated antigen GM3, was prepared and employed to demonstrate that murine melanoma cell B16F0 could be effectively glycoengineered by N-phenylacetyl-d-mannosamine to express N-phenylacetyl GM3 and that 2H3 was highly cytotoxic to the glycoengineered B16F0 cell in the presence of complements. It was further demonstrated that B16F0 cell could be glycoengineered 4-5 times more effectively than 3T3 A31 cell, a normal murine embryo fibroblast cell, and that the antibody and complement mediated cytotoxicity was at least 200 times more potent to the glycoengineered B16F0 cell than to the N-phenylacetyl-d-mannosamine-treated 3T3 A31 cell. These results show the promise for developing useful melanoma immunotherapies based on vaccination against N-phenylacetyl GM3 followed by treatment with N-phenylacetyl-d-mannosamine.

The National Shipbuilding Research Program. Application of Industrial Engineering Techniques to Reduce Workers’ Compensation and Environmental Costs - Deliverable D

DTIC Science & Technology

1999-10-01

Electrostatic guns provide opportunities for exterior application of topcoats such as urethanes, acrylics , alkyds and epoxies. Most shipbuilding...A hybrid of airless spray and conventional air-atomized spray, this kind of gun uses fluid pressures higher than those used in conventional air...voltage) by simply flipping a switch. All essential controls are located right at the back of the gun. Other electrostatic systems require constant

Evaluation of Micronutrient Sensors for Food Matrices in Resource-Limited Settings: A Systematic Narrative Review.

PubMed

Waller, Anna W; Lotton, Jennifer L; Gaur, Shashank; Andrade, Jeanette M; Andrade, Juan E

2018-06-21

In resource-limited settings, mass food fortification is a common strategy to ensure the population consumes appropriate quantities of essential micronutrients. Food and government organizations in these settings, however, lack tools to monitor the quality and compliance of fortified products and their efficacy to enhance nutrient status. The World Health Organization has developed general guidelines known as ASSURED (Affordable, Sensitive, Specific, User-friendly, Rapid and Robust, Equipment-free, and Deliverable to end-users) to aid the development of useful diagnostic tools for these settings. These guidelines assume performance aspects such as sufficient accuracy, reliability, and validity. The purpose of this systematic narrative review is to examine the micronutrient sensor literature on its adherence towards the ASSURED criteria along with accuracy, reliability, and validation when developing micronutrient sensors for resource-limited settings. Keyword searches were conducted in three databases: Web of Science, PubMed, and Scopus and were based on 6-point inclusion criteria. A 16-question quality assessment tool was developed to determine the adherence towards quality and performance criteria. Of the 2,365 retrieved studies, 42 sensors were included based on inclusion/exclusion criteria. Results showed that improvements to the current sensor design are necessary, especially their affordability, user-friendliness, robustness, equipment-free, and deliverability within the ASSURED criteria, and accuracy and validity of the additional criteria to be useful in resource-limited settings. Although it requires further validation, the 16-question quality assessment tool can be used as a guide in the development of sensors for resource-limited settings. © 2018 Institute of Food Technologists®.

New classification of landslide-inducing anthropogenic activities

NASA Astrophysics Data System (ADS)

Michoud, C.; Jaboyedoff, M.; Derron, M.-H.; Nadim, F.; Leroi, E.

2012-04-01

Although landslides are usually considered typical examples of natural hazards, they can be influenced by human activities. Many examples can be found in the literature about slope instabilities induced by anthropogenic activities, ranging from small superficial landslides to rock avalanches. Research on this topic is of primary importance for understanding and mitigation of landslide risk. Indeed, slope stabilities influenced by human actions contribute significantly to the risk level because, by definition, they are located where elements at risk and people are present. Within the framework of the European project SafeLand "Living with Landslide Risk in Europe", the authors analyzed the landslides induced by anthropogenic factors in Europe and elsewhere (SafeLand deliverable D1.6). During the bibliographical research, it appeared that a complete and illustrated classification on human activities influencing slope stabilities does not yet exist. Therefore, a new classification was introduced by Michoud et al. (2011) about anthropogenic activities affecting slope stability conditions. This classification takes into account conceptual processes leading to landslides (Terzaghi, 1950; Jaboyedoff and Derron, 2005) and the distinction between destabilization factors and triggering factors (Vaunat et al., 1994; Leroueil et al., 1996). The classification was tested and improved through fifty-eight well-documented case studies, even lots of large landslides, such as Elm, Aberfan, Namsos and Rissa landslides, etc. Furthermore, the boundary between natural and "anthropogenic" landslide triggers (e.g. water run-off modified by new land-uses, creating landslides some km farther), and the time during which changes and reactions are to be considered as direct consequences of human activities were highlighted. Finally, anthropogenic influences can also be positive and examples of (non-voluntary) positive human impacts on slope stability are presented. Jaboyedoff, M. and Derron, M.-H. 2005. Integrated risk assessment process for landslides. In: Landslide risk management, Hungr, O., Fell, R., Couture, R. and Eberhardt, E. (eds.): 776 p. Leroueil, S., Locat, J., Vaunat, J., Picarelli, L. Lee, H. and Faure, R. 1996. Geotechnical characterization of slope movements, Landslides, Senneset (ed.), 53-73. Michoud, C., Jaboyedoff, M., Derron, M.-H., Nadim, F. and Leroi, E. 2011. Classification of landslide-inducing anthropogenic activities, 5th Canadian Conference on Geotechnique and Natural Hazards, Kelowna, Canada, 10 p. Terzaghi, K. 1950. Mechanism of Landslides, The Geological Society of America, Engineering Geology (Berkley) Volume, 83-123. Vaunat, J., Leroueil, S. and Faure, R. 1994. Slope movements: a geotechnical perspective. Proc. 7th Int. Congress of Int. Association of Engineering Geology, Oliveira (ed.), 1637-1646.

Unclassified Publications of Lincoln Laboratory, 1 January - 31 December 1996, Volume 22.

DTIC Science & Technology

1996-12-31

Combination Necioglu, B.F Paul, D.B. Billingsley, J.B. Shirley, L.G. Hallerman , G.R. Yang, D.W. Dionne, G.F. Wallace, T.P. 16 Dec. 1996 29 July...7236A, JA-7263, MS-11826 Hallerman , G.R., TR-1025 Halpern, B.L., MS-11108 Haiversen, S.D., MS-10981, MS-11090, MS-11418 Haner, M., JA-7236A

Noise-induced hearing loss induces loudness intolerance in a rat Active Sound Avoidance Paradigm (ASAP).

PubMed

Manohar, Senthilvelan; Spoth, Jaclyn; Radziwon, Kelly; Auerbach, Benjamin D; Salvi, Richard

2017-09-01

Hyperacusis is a loudness hypersensitivity disorder in which moderate-intensity sounds are perceived as extremely loud, aversive and/or painful. To assess the aversive nature of sounds, we developed an Active Sound Avoidance Paradigm (ASAP) in which rats altered their place preference in a Light/Dark shuttle box in response to sound. When no sound (NS) was present, rats spent more than 95% of the time in the Dark Box versus the transparent Light Box. However, when a 60 or 90 dB SPL noise (2-20 kHz, 2-8 kHz, or 16-20 kHz bandwidth) was presented in the Dark Box, the rats'' preference for the Dark Box significantly decreased. Percent time in the dark decreased as sound intensity in the Dark Box increased from 60 dB to 90 dB SPL. Interestingly, the magnitude of the decrease was not a monotonic function of intensity for the 16-20 kHz noise and not related to the bandwidth of the 2-20 kHz and 2-8 kHz noise bands, suggesting that sound avoidance is not solely dependent on loudness but the aversive quality of the noise as well. Afterwards, we exposed the rats for 28 days to a 16-20 kHz noise at 102 dB SPL; this exposure produced a 30-40 dB permanent threshold shift at 16 and 32 kHz. Following the noise exposure, the rats were then retested on the ASAP paradigm. High-frequency hearing loss did not alter Dark Box preference in the no-sound condition. However, when the 2-20 kHz or 2-8 kHz noise was presented at 60 or 90 dB SPL, the rats avoided the Dark Box significantly more than they did before the exposure, indicating these two noise bands with energy below the region of hearing loss were perceived as more aversive. In contrast, when the 16-20 kHz noise was presented at 60 or 90 dB SPL, the rats remained in the Dark Box presumably because the high-frequency hearing loss made 16-20 kHz noise less audible and less aversive. These results indicate that when rats develop a high-frequency hearing loss, they become less tolerant of low frequency noise, i.e., high intensity sounds are perceived as more aversive and should be avoided. Published by Elsevier B.V.

Silver deposited carboxymethyl chitosan-grafted magnetic nanoparticles as dual action deliverable antimicrobial materials.

PubMed

Vo, Duc-Thang; Sabrina, Sabrina; Lee, Cheng-Kang

2017-04-01

Carboxymethyl chitosan (CMCS) was known to have a much better antimicrobial activity than chitosan due to the increased cationic -NH 3 + groups resulted from the intra- and intermolecular interactions between the carboxyl and amino groups. CMCS was grafted onto the surface of silica coated magnetic nanoparticles (MNPs) to obtain magnetically retrievable and deliverable antimicrobial nanoparticles (MNPs@CMCS). The presence of carboxylate groups in CMCS not only enhanced antimicrobial activity but also enabled Ag ions chelating ability to induce the in situ formation of Ag nanoparticles (AgNPs). The deposition of AgNPs on the surface of MNPs@CMCS could significantly increase its antimicrobial activity against planktonic cells due to the dual action of CMCS and AgNPs. Due to its high magnetism, the as-prepared MNPs@CMCS-Ag could be efficiently delivered into an existing biofilm under the guidance of an applied magnetic field. Without direct contact, the Ag ions and/or radical oxygen species (ROS) released from the deposited Ag nanoparticles could effectively kill the bacteria embedded in the extracellular polymeric substances (EPS) matrix of biofilm. Copyright © 2016 Elsevier B.V. All rights reserved.

17 CFR 36.2 - Exempt boards of trade.

Code of Federal Regulations, 2011 CFR

2011-04-01

... Section 36.2 Commodity and Securities Exchanges COMMODITY FUTURES TRADING COMMISSION EXEMPT MARKETS § 36.2... deliverable supply; (ii) A deliverable supply that is sufficiently large, and a cash market sufficiently... manipulation; or (iii)No cash market. (2) The commodities that meet the criteria of paragraph (a)(1) of this...

17 CFR 36.2 - Exempt boards of trade.

Code of Federal Regulations, 2010 CFR

2010-04-01

... Section 36.2 Commodity and Securities Exchanges COMMODITY FUTURES TRADING COMMISSION EXEMPT MARKETS § 36.2... deliverable supply; (ii) A deliverable supply that is sufficiently large, and a cash market sufficiently... manipulation; or (iii)No cash market. (2) The commodities that meet the criteria of paragraph (a)(1) of this...

17 CFR 36.2 - Exempt boards of trade.

Code of Federal Regulations, 2012 CFR

2012-04-01

... Section 36.2 Commodity and Securities Exchanges COMMODITY FUTURES TRADING COMMISSION EXEMPT MARKETS § 36.2... deliverable supply; (ii) A deliverable supply that is sufficiently large, and a cash market sufficiently... manipulation; or (iii)No cash market. (2) The commodities that meet the criteria of paragraph (a)(1) of this...

Altarum restricted use technology study : interim report, deliverable 3.1 : list of invitees for the focus group

DOT National Transportation Integrated Search

2005-09-01

This study, an 18-month effort, seeks to apply restricted use technology to the mandates of MDOT. For Deliverable 3.1 described in the Work Plan governing the Altarum Restricted Use Technology Study, the Altarum project team is required to provide a ...

Mapping of a locus for a familial autosomal recessive idiopathic myoclonic epilepsy of infancy to chromosome 16p13.

PubMed Central

Zara, F; Gennaro, E; Stabile, M; Carbone, I; Malacarne, M; Majello, L; Santangelo, R; de Falco, F A; Bricarelli, F D

2000-01-01

Myoclonic epilepsies with onset in infancy and childhood are clinically and etiologically heterogeneous. Although genetic factors are thought to play an important role, to date very little is known about the etiology of these disorders. We ascertained a large Italian pedigree segregating a recessive idiopathic myoclonic epilepsy that starts in early infancy as myoclonic seizures, febrile convulsions, and tonic-clonic seizures. We typed 304 microsatellite markers spanning the 22 autosomes and mapped the locus on chromosome 16p13 by linkage analysis. A maximum LOD score of 4.48 was obtained for marker D16S3027 at recombination fraction 0. Haplotype analysis placed the critical region within a 3.4-cM interval between D16S3024 and D16S423. The present report constitutes the first example of an idiopathic epilepsy that is inherited as an autosomal recessive trait. PMID:10741954

Design and performance of 10-Gb/s L-band REAM-SOA for OLT Transmitter in next generation access networks.

PubMed

Lee, Dong-Hun; Jeong, Jong Sool; Kim, Ki-Soo; Kim, Hyun-Soo; Kim, Dong Churl; Park, Mi-Ran; Han, Yong-Tak; Kwon, Oh Kee; Kwon, O-Kyun

2015-02-09

We present a 10-Gb/s L-band reflective electro-absorption modulator integrated with a semiconductor optical amplifier (REAM-SOA) having improved transmission performance at very low input power of seed light. To decrease the input power of seed light, the absorption characteristics of the REAM are adjusted to reduce the amplified spontaneous emission light returned into the SOA, suppressing the gain saturation effect of the SOA. At a considerably low input power of -16 dBm, the REAM-SOA exhibits a low transmission penalty of about 1.2 dB after 50-km SMF transmission. Over a wide input power range from -16 dBm to 5 dBm, a penalty of less than 1.6 dB is achieved at 50-km transmission.

Nyquist WDM superchannel using offset-16QAM and receiver-side digital spectral shaping.

PubMed

Xiang, Meng; Fu, Songnian; Tang, Ming; Tang, Haoyuan; Shum, Perry; Liu, Deming

2014-07-14

The performance of Nyquist WDM superchannel using advanced modulation formats with coherent detection is degraded due to the existence of both inter-symbol interference (ISI) and inter-channel interference (ICI). Here, we propose and numerically investigate a Nyquist WDM superchannel using offset-16QAM and receiver-side digital spectral shaping (RS-DSS), achieving a spectral efficiency up to 7.44 bit/s/Hz with 7% hard-decision forward error correction (HD-FEC) overhead. Compared with Nyquist WDM superchannel using 16QAM and RS-DSS, the proposed system has 1.4 dB improvement of required OSNR at BER = 10(-3) in the case of back-to-back (B2B) transmission. Furthermore, the range of launched optical power allowed beyond HD-FEC threshold is drastically increased from -6 dBm to 1.2 dBm, after 960 km SSMF transmission with EDFA-only. In particular, no more than 1.8 dB required OSNR penalty at BER = 10(-3) is achieved for the proposed system even with the phase difference between channels varying from 0 to 360 degree.

A novel system for constructing a recombinant highly-attenuated vaccinia virus strain (LC16m8) expressing foreign genes and its application for the generation of LC16m8-based vaccines against herpes simplex virus 2.

PubMed

Omura, Natsumi; Yoshikawa, Tomoki; Fujii, Hikaru; Shibamura, Miho; Inagaki, Takuya; Kato, Hirofumi; Egawa, Kazutaka; Harada, Shizuko; Yamada, Souichi; Takeyama, Haruko; Saijo, Masayuki

2018-04-27

A novel system was developed for generating a highly-attenuated vaccinia virus LC16m8 (m8, third generation smallpox vaccine) that expresses foreign genes. The innovations in this system are its excisable selection marker, specificity of the integration site of a gene of interest, and easy identification of clones with the fluorescent signal. Using this system, recombinant m8s, which expressed either herpes simplex virus 2 (HSV-2) glycoprotein B (gB)-, gD-, or both gB and gD (gB+gD) were developed, and their efficacy was evaluated. First, the induction of a specific IgG against these HSV-2 glycoproteins in mice infected with each of these recombinant m8s was confirmed with an immunofluorescence assay. Next, mice pre-infected with each of the recombinant m8s were infected with HSV-2 at the lethal dose to examine the vaccine efficacy. The fatality rate in mice pre-infected with either of the recombinant gB+gD- or gD-expressing m8s significantly decreased in comparison with that of the control. The survival rate in both male and female mice pre-infected with either of the recombinant gB+gD- and gD-expressing m8s increased to 100 % and 60 %, respectively, while most of the control mice died. In summary, this new system might be applicable for generating a novel m8-based vaccine.

Building a Competitive Edge with Additive Manufacturing

DTIC Science & Technology

2013-02-14

construct ceramic molds for complex metal parts using a 3D printing technique. They estimate the new 6 technique could eliminate all of the...processes. They include 3D printing and Additive Beam Techniques.15 Most Additive Manufacturing techniques are specific to certain classes of materials...9 Example Additive Manufacturing Techniques16 3D Printing Additive Beam Stereolithography (SLA) Direct Metal Laser Sintering (DMLS

Advances in Additive Manufacturing

DTIC Science & Technology

2016-07-14

of 3D - printed structures. Analysis examples will include quantification of tolerance differences between the designed and manufactured parts, void...15. SUBJECT TERMS 3-D printing , validation and verification, nondestructive inspection, print -on-the-move, prototyping 16. SECURITY CLASSIFICATION...researching the formation of AM-grade metal powder from battlefield scrap and operating base waste, 2) potential of 3-D printing with sand to make

Feasibility Study for Low Drag Acoustic Liners Final Report

NASA Technical Reports Server (NTRS)

Riedel, Brian; Wu, Jackie

2017-01-01

This report documents the design and structural analysis as a final deliverable for the Phase 1 contract activity. Also included is a community noise test plan, which is a key deliverable for Phase 2. Finally, a high-level estimate (Phase 3 deliverable) is provided for the work statement of Phases 2-4, which covers the build of two inlet test articles, planning and execution of a flight test with the test inlets, as well as data analysis and final documentation. The two test inlets will be compared to the production baseline inlet configuration. There is also a plan to test one of the inlets "hardwalled" using speed tape or some other similar tape to block the acoustic perforations.

Chamber B Thermal/Vacuum Chamber: User Test Planning Guide

NASA Technical Reports Server (NTRS)

Montz, Mike E.

2012-01-01

Test process, milestones and inputs are unknowns to first-time users of Chamber B. The User Test Planning Guide aids in establishing expectations for both NASA and non-NASA facility customers. The potential audience for this guide includes both internal and commercial spaceflight hardware/software developers. It is intended to assist their test engineering personnel in test planning and execution. Material covered includes a roadmap of the test process, roles and responsibilities of facility and user, major milestones, facility capabilities, and inputs required by the facility. Samples of deliverables, test article interfaces, and inputs necessary to define test scope, cost, and schedule are included as an appendix to the guide.

Bioactive constituents from Chinese natural medicines. XXXII. aminopeptidase N and aldose reductase inhibitors from Sinocrassula indica: structures of sinocrassosides B(4), B(5), C(1), and D(1)-D(3).

PubMed

Morikawa, Toshio; Xie, Haihui; Wang, Tao; Matsuda, Hisashi; Yoshikawa, Masayuki

2008-10-01

From the methanolic extract of the whole plant of Sinocrassula indica (Crassulaceae), six new flavonol glycosides, sinocrassosides B(4) (1), B(5) (2), C(1) (3), D(1) (4), D(2) (5), and D(3) (6), were isolated together with 30 compounds. The structures of 1-6 were elucidated on the basis of chemical and physicochemical evidence. In addition, several constituents were found to show inhibitory effects on aminopeptidase N and aldose reductase.

SU-F-T-344: Commissioning Constant Dose Rate VMAT in the Raystation Treatment Planning System for a Varian Clinac IX

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pursley, J; Gueorguiev, G; Prichard, H

Purpose: To demonstrate the commissioning of constant dose rate volumetric modulated arc therapy (VMAT) in the Raystation treatment planning system for a Varian Clinac iX with Exact couch. Methods: Constant dose rate (CDR) VMAT is an option in the Raystation treatment planning system, enabling VMAT delivery on Varian linacs without a RapidArc upgrade. Raystation 4.7 was used to commission CDR-VMAT for a Varian Clinac iX. Raystation arc model parameters were selected to match machine deliverability characteristics. A Varian Exact couch model was added to Raystation 4.7 and commissioned for use in VMAT optimization. CDR-VMAT commissioning checks were performed on themore » linac, including patient-specific QA measurements for 10 test patients using both the ArcCHECK from Sun Nuclear Corporation and COMPASS from IBA Dosimetry. Multi-criteria optimization (MCO) in Raystation was used for CDR-VMAT planning. Results: Raystation 4.7 generated clinically acceptable and deliverable CDR-VMAT plans for the Varian Clinac. VMAT plans were optimized including a model of the Exact couch with both rails in the out positions. CDR-VMAT plans generated with MCO in Raystation were dosimetrically comparable to Raystation MCO-generated IMRT plans. Patient-specific QA measurements with the ArcCHECK on the couch showed good agreement with the treatment planning system prediction. Patient-specific, structure-specific, multi-statistical parameter 3D QA measurements with gantry-mounted COMPASS also showed good agreement. Conclusion: Constant dose rate VMAT was successfully modeled in Raystation 4.7 for a Varian Clinac iX, and Raystation’s multicriteria optimization generated constant dose rate VMAT plans which were deliverable and dosimetrically comparable to IMRT plans.« less

[Genetic diversity and phylogeny of rhizobia isolated from peanut (Arachis hypogaea)].

PubMed

Yang, Jiang-Ke; Xie, Fu-Li; Zhou, Jun-Chu

2002-12-01

Forty three rhizobium strains isolated from peanut (Arachis hypogaea) and 15 reference strains from other genus and species were analyzed by the method of 16S rRNA RFLP, 16S rRNA sequencing and 16S-23S IGS PCR RFLP. The results of the 16S rRNA RFLP shown that 43 strains tested were all ascribed to the genus of Bradyrhizobium phylogenetically. Strains tested were adjacent to the B. japonicum and far from B. elkanii 16S rRNA genotype. The genotypes generated by the 4 restriction endonucleases, Mbo I, Dde I, Hae III and Msp I, were same as the representatives of B. japonicum. The dendrogram generated by 16S rRNA sequence and Neighbor-joining method shown that peanut rhizobia clustered into the subcluster represented by B. japonicum and B. liaoningense, were more close to B. liaoningense genetically, and the sequence difference between them was less than 1%. High sequence similarity was also determined between B. liaoningense and B. japonicum. JZ1, representative strain of peanut rhizobia were systematically far from the B. elkanii, and the sequence divergence about 2%. The results from IGS RFLP analysis indicated that although they were phylogenetically close to B. japonicum and B. elkanii, peanut rhizobia forming an independent group at the similarity of 71% could be further divided into four subgroups, A, B, C and D. Subgroup A consisted of strains from different region, subgroup B was composed of strains from Wuchang, Qianjiang and Jingzhou, subgroup C was mainly composed of strains from Jingzhou and starins of subgroup D mainly from Neijiang. Reference strains from B. japonicum and B. elkanii were independently clustered into the subgroup E at the similarity of 71%. The geographical factor effect on genetic diversity of rhizobia was found.

78 FR 35338 - Self-Regulatory Organizations; BOX Options Exchange LLC; Notice of Filing and Immediate...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-12

... trading option contracts overlying 1,000 SPDR[supreg] S&P 500[supreg] exchange-traded fund shares (``SPY''),\\3\\ or (``Jumbo SPY Options'').\\4\\ Whereas standard options contracts represent a deliverable of 100... the number of deliverable shares, Jumbo SPY Options have the same terms and contract characteristics...

A Quantitative Study into the Information Technology Project Portfolio Practice: The Impact on Information Technology Project Deliverables

ERIC Educational Resources Information Center

Yu, Wei

2013-01-01

This dissertation applied the quantitative approach to the data gathered from online survey questionnaires regarding the three objects: Information Technology (IT) Portfolio Management, IT-Business Alignment, and IT Project Deliverables. By studying this data, this dissertation uncovered the underlying relationships that exist between the…

Synthetic Report of Research and Development of Professional Knowledge Practices

ERIC Educational Resources Information Center

Toiviainen, Hanna; Hoynalanmaa, Mikko; Lallimo, Jiri; Moen, Anne; Smordal, Ole; Morch, Anders; Toikka, Seppo

2006-01-01

This deliverable has been produced in the context of the Knowledge-Practice Laboratory (KP-Lab) project, which is aimed at facilitating innovative practices of working with knowledge in higher education, teacher training, and professional networks. This deliverable is a synopsis of the first experiences encountered during the first 6 months of the…

Deliberately Designed Atomic-Level Silver-Containing Interface Results in Improved Rate Capability and Utilization of Silver Hollandite for Lithium-Ion Storage

DOE Office of Scientific and Technical Information (OSTI.GOV)

Smith, Paul F.; Brady, Alexander B.; Lee, Seung-Yong

α-MnO 2-structured materials are generally classified as semiconductors, thus we present a strategy to increase electrochemical utilization through design of a conductive material interface. Surface treatment of silver hollandite (Ag xMn 8O 16) with Ag + (Ag 2O) provides significant benefit to the resultant electrochemistry, including a decreased charge transfer resistance, and a 2-fold increase in deliverable energy density at high rate. The improved function of this designed interface relative to conventional electrode fabrication strategies is further highlighted.

Deliberately Designed Atomic-Level Silver-Containing Interface Results in Improved Rate Capability and Utilization of Silver Hollandite for Lithium-Ion Storage

DOE PAGES

Smith, Paul F.; Brady, Alexander B.; Lee, Seung-Yong; ...

2017-12-11

α-MnO 2-structured materials are generally classified as semiconductors, thus we present a strategy to increase electrochemical utilization through design of a conductive material interface. Surface treatment of silver hollandite (Ag xMn 8O 16) with Ag + (Ag 2O) provides significant benefit to the resultant electrochemistry, including a decreased charge transfer resistance, and a 2-fold increase in deliverable energy density at high rate. The improved function of this designed interface relative to conventional electrode fabrication strategies is further highlighted.

Early Identification of SE-Related Program Risks: Opportunities for DoD Systems Engineering (SE) Transformation via SE Effectiveness Measures (EMs) and Evidence-Based Reviews

DTIC Science & Technology

2009-09-30

development of feasibility evidence for a 100-KSLOC project . It is good to note that the “sweet spots” are...incomplete without the FED, it becomes a first-class project deliverable. This implies that it needs a plan for its development , and that each task in...effective in supporting an aerospace flight hardware program at NASA; however, differences in the models used for project development and

Innovative Techniques for the Production of Low Cost 2D Laser Diode Arrays. Supplies or Services and Prices/Costs

DTIC Science & Technology

1991-12-31

continue on facet coatings, PL correlation to device performance, and CVD diamond. All global issues mentioned in Section 2.0 will be addresses and...The CVD diamond submounts will be hermetically sealed, electrically isolated and liquid cooled. (Deliverables: 5 5-bar arrays.) The following global ... issues not mentioned above will be investigated continuously throughout all four phases of this program: (1) design and development of a mask set to

A Ka-Band Wide-Bandgap Solid-State Power Amplifier: Architecture Performance Estimates

NASA Technical Reports Server (NTRS)

Epp, L.; Khan, P.; Silva, A.

2005-01-01

Motivated by recent advances in wide-bandgap (WBG) gallium nitride (GaN) semiconductor technology, there is considerable interest in developing efficient solidstate power amplifiers (SSPAs) as an alternative to the traveling-wave tube amplifier (TWTA) for space applications. This article documents the results of a study to investigate power-combining technology and SSPA architectures that can enable a 120-W, 40 percent power-added efficiency (PAE) SSPA. Results of the study indicate that architectures based on at least three power combiner designs are likely to enable the target SSPA. The proposed architectures can power combine 16 to 32 individual monolithic microwave integrated circuits (MMICs) with >80 percent combining efficiency. This corresponds to MMIC requirements of 5- to 10-W output power and >48 percent PAE. For the three proposed architectures [1], detailed analysis and design of the power combiner are presented. The first architecture studied is based on a 16-way septum combiner that offers low loss and high isolation over the design band of 31 to 36 GHz. Analysis of a 2-way prototype septum combiner had an input match >25 dB, output match >30 dB, insertion loss <0.02 dB, and isolation >30 dB over the design band. A 16-way design, based on cascading this combiner in a binary fashion, is documented. The second architecture is based on a 24-way waveguide radial combiner. A prototype 24-way radial base was analyzed to have an input match >30 dB (under equal excitation of all input ports). The match of the mode transducer that forms the output of a radial combiner was found to be >27 dB. The functional bandwidth of the radial base and mode transducer, which together will form a radial combiner/divider, exceeded the design band. The third architecture employs a 32-way, parallel-plate radial combiner. Simulation results indicated an input match >24 dB, output match >22 dB, insertion loss <0.23 dB, and adjacent port isolation >20 dB over the design band. All three architectures utilize a low-loss MMIC amplifier module based on commercial MMIC packaging and a custom microstrip-to-rectangular-waveguide transition. The insertion loss of the module is expected to be 0.45 dB over the design band.

26 CFR 1.21-1 - Expenses for household and dependent care services necessary for gainful employment.

Code of Federal Regulations, 2013 CFR

2013-04-01

..., E, works at night and sleeps during the day. D and E pay for care for a qualifying individual during... this paragraph (a) are illustrated by the following examples. Example 1. In December 2007, B pays for... B pays for the care provided in January 2008 on February 3, 2008. Under paragraph (a)(4) of this...

26 CFR 1.21-1 - Expenses for household and dependent care services necessary for gainful employment.

Code of Federal Regulations, 2014 CFR

2014-04-01

..., E, works at night and sleeps during the day. D and E pay for care for a qualifying individual during... this paragraph (a) are illustrated by the following examples. Example 1. In December 2007, B pays for... B pays for the care provided in January 2008 on February 3, 2008. Under paragraph (a)(4) of this...

26 CFR 1.21-1 - Expenses for household and dependent care services necessary for gainful employment.

Code of Federal Regulations, 2012 CFR

2012-04-01

..., E, works at night and sleeps during the day. D and E pay for care for a qualifying individual during... this paragraph (a) are illustrated by the following examples. Example 1. In December 2007, B pays for... B pays for the care provided in January 2008 on February 3, 2008. Under paragraph (a)(4) of this...

Saponins from Albizia lebbeck.

PubMed

Pal, B C; Achari, B; Yoshikawa, K; Arihara, S

1995-03-01

Three main saponins named albiziasaponins A, B, and C were isolated from the barks of Albizia lebbeck. Their structures were established through spectral analyses as acacic acid lactone 3-O-beta-D-xylopyranosyl-(1-->2)-alpha-L-arabinopyranosyl-(1-->6)- beta-D-glucopyranoside, 3-O-beta-D-glucopyranosyl-(1-->2)-O-[alpha-L-arabinopyranosyl-(1-- >6)]- beta-D-glucopyranoside and 3-O-beta-D-xylopyranosyl-(1-->2)-alpha-L-arabinopyranosyl-(1-->6)- O- [beta-D-glucopyranosyl-(1-->2)]-beta-D-glucopyranoside.

Tree attenuation at 20 GHz: Foliage effects

NASA Technical Reports Server (NTRS)

Vogel, Wolfhard J.; Goldhirsh, Julius

1993-01-01

Static tree attenuation measurements at 20 GHz (K-Band) on a 30 deg slant path through a mature Pecan tree with and without leaves showed median fades exceeding approximately 23 dB and 7 dB, respectively. The corresponding 1% probability fades were 43 dB and 25 dB. Previous 1.6 GHz (L-Band) measurements for the bare tree case showed fades larger than those at K-Band by 3.4 dB for the median and smaller by approximately 7 dB at the 1% probability. While the presence of foliage had only a small effect on fading at L-Band (approximately 1 dB additional for the median to 1% probability range), the attenuation increase was significant at K-Band, where it increased by about 17 dB over the same probability range.

Tree attenuation at 20 GHz: Foliage effects

NASA Astrophysics Data System (ADS)

Vogel, Wolfhard J.; Goldhirsh, Julius

1993-08-01

Static tree attenuation measurements at 20 GHz (K-Band) on a 30 deg slant path through a mature Pecan tree with and without leaves showed median fades exceeding approximately 23 dB and 7 dB, respectively. The corresponding 1% probability fades were 43 dB and 25 dB. Previous 1.6 GHz (L-Band) measurements for the bare tree case showed fades larger than those at K-Band by 3.4 dB for the median and smaller by approximately 7 dB at the 1% probability. While the presence of foliage had only a small effect on fading at L-Band (approximately 1 dB additional for the median to 1% probability range), the attenuation increase was significant at K-Band, where it increased by about 17 dB over the same probability range.

Model-independent analysis of semileptonic B decays to D** for arbitrary new physics

NASA Astrophysics Data System (ADS)

Bernlochner, Florian U.; Ligeti, Zoltan; Robinson, Dean J.

2018-04-01

We explore semileptonic B decays to the four lightest excited charm mesons, D**={D0*,D1* ,D1 ,D2*} , for nonzero charged lepton mass and for all b →c ℓν ¯ four-Fermi interactions, including calculation of the O (ΛQCD/mc ,b) and O (αs) corrections to the heavy quark limit for all form factors. In the heavy quark limit, some form factors are suppressed at zero recoil; therefore, the O (ΛQCD/mc ,b) corrections can be very important. The D** rates exhibit sensitivities to new physics in b →c τ ν ¯ mediated decays complementary to the D and D* modes. Since they are also important backgrounds to B →D(*)τ ν ¯, the correct interpretation of future semitauonic B →D(*) rate measurements requires consistent treatment of both the D** backgrounds and the signals. Our results allow more precise and more reliable calculations of these B →D**ℓν ¯ decays and are systematically improvable by better data on the e and μ modes. As an example, we show that the D** rates are more sensitive to a new c ¯ σμ νb tensor interaction than the D(*) rates.

16 CFR 432.1 - Scope.

Code of Federal Regulations, 2010 CFR

2010-01-01

... HOME ENTERTAINMENT PRODUCTS § 432.1 Scope. (a) Except as provided in paragraph (b) of this section... entertainment purposes, such as for example, radios, record and tape players, radio-phonograph and/or tape...

16 CFR 432.1 - Scope.

Code of Federal Regulations, 2012 CFR

2012-01-01

... HOME ENTERTAINMENT PRODUCTS § 432.1 Scope. (a) Except as provided in paragraph (b) of this section... entertainment purposes, such as for example, radios, record and tape players, radio-phonograph and/or tape...

16 CFR 432.1 - Scope.

Code of Federal Regulations, 2013 CFR

2013-01-01

... HOME ENTERTAINMENT PRODUCTS § 432.1 Scope. (a) Except as provided in paragraph (b) of this section... entertainment purposes, such as for example, radios, record and tape players, radio-phonograph and/or tape...

16 CFR 432.1 - Scope.

Code of Federal Regulations, 2014 CFR

2014-01-01

... HOME ENTERTAINMENT PRODUCTS § 432.1 Scope. (a) Except as provided in paragraph (b) of this section... entertainment purposes, such as for example, radios, record and tape players, radio-phonograph and/or tape...

Photoelectron Spectroscopic and Theoretical Study of B-16(-) and B-16(2-): An All-Boron Naphthalene

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sergeeva, Alina P.; Zubarev, Dmitry Y.; Zhai, Hua Jin

Although boron clusters were experimentally studied shortly after the discovery of the fullerenes, their structural characterization was only possible fairly recently when we combined photoelectron spectroscopy (PES) and theoretical calculations to investigate the structures and bonding of boron clusters. Early theoretical studies indicated that small boron clusters do not assume cage-like structures, which are common in bulk boron and compounds; instead, planar or quasi-planar structures were suggested. The combined PES and theoretical studies show indeed boron clusters with up to 15 atom are planar, and only at B20 does a three-dimensional (3D) structure (double ring) become energetically competitive, whereas B20-more » still remains planar. A recent ion mobility and theoretical study showed that for Bn + the doublering 3D structure becomes competitive at B16 +7.« less

Synthesis of geophysical data (phase V, deliverable 55): Chapter B in Second projet de renforcement institutionnel du secteur minier de la République Islamique de Mauritanie (PRISM-II)

USGS Publications Warehouse

Finn, Carol A.; Anderson, Eric D.

2015-01-01

Aeromagnetic and radiometric data were used to map shallow Precambrian basement lithology and structure and determine the depth to magnetic basement, which in most cases, corresponds to the depth to crystalline basement of interest for mineral exploration. These depths, along with those determined from gravity data, help identify basins with hydrologic potential. In addition, the magnetic data were used to identify buried Precambrian rocks of unknown affinity.

Chemical Stockpile Disposal Program. Risk Analysis of the Continued Storage of Chemical Munitions

DTIC Science & Technology

1987-08-01

Grass Army Depot LIC liquid incinerator LPF leakers processing facility LPG liquified propane gas MD)B munitions demilitarization building"I 1DIA mu...screening process , con- sidering both frequency and magnitude of agent release, are included in the deliverables of this project. S.1.3. Scove of Study...simplistic terms the PRA process focuses on answering the fol- •• loving three basic questions: 1. Wh.t can go wrong? 2. How frequently is it expected to

Prolonged noise exposure-induced auditory threshold shifts in rats

PubMed Central

Chen, Guang-Di; Decker, Brandon; Muthaiah, Vijaya Prakash Krishnan; Sheppard, Adam; Salvi, Richard

2014-01-01

Noise-induced hearing loss (NIHL) initially increases with exposure duration, but eventually reaches an asymptotic threshold shift (ATS) once the exposure duration exceeds 18-24 h. Equations for predicting the ATS have been developed for several species, but not for rats, even though this species is extensively used in noise exposure research. To fill this void, we exposed rats to narrowband noise (NBN, 16-20 kHz) for 5 weeks starting at 80 dB SPL in the first week and then increasing the level by 6 dB per week to a final level of 104 dB SPL. Auditory brainstem responses (ABR) were recorded before, during, and following the exposure to determine the amount of hearing loss. The noise induced threshold shift to continuous long-term exposure, defined as compound threshold shift (CTS), within and above 16-20 kHz increased with noise level at the rate of 1.82 dB threshold shift per dB of noise level (NL) above a critical level (C) of 77.2 dB SPL i.e. CTS = 1.82(NL-77.2). The normalized amplitude of the largest ABR peak measured at 100 dB SPL decreased at the rate of 3.1% per dB of NL above the critical level of 76.9 dB SPL, i.e., %ABR Reduction = 3.1%(NL-76.9). ABR thresholds measured >30 days post-exposure only partially recovered resulting in a permanent threshold shift of 30-40 dB along with severe hair cell loss in the basal, high-frequency region of the cochlea. In the rat, CTS increases with noise level with a slope similar to humans and chinchillas. The critical level (C) in the rat is similar to that of humans, but higher than that of chinchillas. PMID:25219503

Investigation of Performance of Concrete and Concreting Materials Exposed to Natural Weathering. Volume 1. Active Investigations. Revision

DTIC Science & Technology

1980-08-01

Ms. K. Mather, Messrs. B. Mather, J. M. Scanlon, B. R. Sullivan, R. V. Tye, Jr., E. E. McCoy, E. C. Roshore, H. T. Thornton, R. E. Black, D. Glass , D...Investigations, Phases D (CW R&D) Section 9: Passamaquoddy Tidal Power Project Section 10: Missouri River Division Program Section 1: Portland Blast-Furnace Slag ...Missouri River Division Props.m 3- by 4-1/2- by 16-in. beam 3 2 No? 1965 10 pack 5 Portland lst-Puiiace Slag 3-1/2- by 1-1/2- by 16-in. beam 108 66 May

Measuring hearing in the harbor seal (Phoca vitulina): Comparison of behavioral and auditory brainstem response techniques

NASA Astrophysics Data System (ADS)

Wolski, Lawrence F.; Anderson, Rindy C.; Bowles, Ann E.; Yochem, Pamela K.

2003-01-01

Auditory brainstem response (ABR) and standard behavioral methods were compared by measuring in-air audiograms for an adult female harbor seal (Phoca vitulina). Behavioral audiograms were obtained using two techniques: the method of constant stimuli and the staircase method. Sensitivity was tested from 0.250 to 30 kHz. The seal showed good sensitivity from 6 to 12 kHz [best sensitivity 8.1 dB (re 20 μPa2.s) RMS at 8 kHz]. The staircase method yielded thresholds that were lower by 10 dB on average than the method of constant stimuli. ABRs were recorded at 2, 4, 8, 16, and 22 kHz and showed a similar best range (8-16 kHz). ABR thresholds averaged 5.7 dB higher than behavioral thresholds at 2, 4, and 8 kHz. ABRs were at least 7 dB lower at 16 kHz, and approximately 3 dB higher at 22 kHz. The better sensitivity of ABRs at higher frequencies could have reflected differences in the seal's behavior during ABR testing and/or bandwidth characteristics of test stimuli. These results agree with comparisons of ABR and behavioral methods performed in other recent studies and indicate that ABR methods represent a good alternative for estimating hearing range and sensitivity in pinnipeds, particularly when time is a critical factor and animals are untrained.

A Theoretical and Experimental Investigation of Transonic Flow in the Throat Region of Annular Axisymmetric, Supersonic Nozzles.

DTIC Science & Technology

1980-01-01

conditions but low enough so that sufficient time vdis available to record the data in these blowdown tests. For these reasons the Reynolds number based on...D1m2 3 2 0 16 D124 8 + 14D20 (B-270) C125 20-1620 DD 14 (C =2s Do~ + P 4(B-271) { , { 160 VI 26 64 13D20 - 2048 D1314 (B-272) 2 C19 + Di19 CDI2 1

Seeing is believing: good graphic design principles for medical research.

PubMed

Duke, Susan P; Bancken, Fabrice; Crowe, Brenda; Soukup, Mat; Botsis, Taxiarchis; Forshee, Richard

2015-09-30

Have you noticed when you browse a book, journal, study report, or product label how your eye is drawn to figures more than to words and tables? Statistical graphs are powerful ways to transparently and succinctly communicate the key points of medical research. Furthermore, the graphic design itself adds to the clarity of the messages in the data. The goal of this paper is to provide a mechanism for selecting the appropriate graph to thoughtfully construct quality deliverables using good graphic design principles. Examples are motivated by the efforts of a Safety Graphics Working Group that consisted of scientists from the pharmaceutical industry, Food and Drug Administration, and academic institutions. Copyright © 2015 John Wiley & Sons, Ltd.

[Effects of infrasound on activities of 3beta hydroxysteroid dehydrogenase and acid phosphatase of polygonal cells in adrenal cortex zona fasciculate in mice].

PubMed

Dang, Wei-min; Wang, Sheng; Tian, Shi-xiu; Chen, Bing; Sun, Fei; Li, Wei; Jiao, Yan; He, Li-hua

2007-02-01

To explore the biological effects of infrasound on the polygonal cells in adrenal cortex zona fasciculation in mice. The biological effects of infrasound on the activities of 3beta hydroxysteroid dehydrogenase (3-betaHSDH) and acid phosphatase(ACP) of the polygonal cells in adrenal cortex zona fasciculate were observed when exposure to 8 and 16 Hz infrasound at 80, 90, 100, 110, 120 and 130 dB for 1 day, 7 days and 14 days or 14 days after the exposure. When exposure to 8 Hz infrasound, the enzyme activities of 3-betaHSDH increase as the sound pressure levels increase. Only when the sound pressure levels reach 130 dB, the enzyme activities began to decrease exceptionally. When exposure to 16 Hz, 80 dB infrasound, no significant difference between the treatment and control group in the activities of 3-betaHSDH could be observed, but the injury of the polygonal cells had appeared. When exposure to 16 Hz, 100 dB infrasound, the activities of 3-betaHSDH started to increase. The cell injury still existed. When exposed to 16 Hz, 120 dB infrasound, the local tissue damage represented. Fourteen days after the mice exposure to 8 Hz, 90 dB and 130 dB infrasound for 14 days continuously, the local tissue injury of the adrenal cortex zona fasciculation began to recover at certain extent, but the higher the exposure sound pressure level, the poorer the tissue recovery. The biological effects of infrasound on the polygonal cells in adrenal cortex zona fasciculation response to the frequency of the infrasound are found at certain action strength range, but this characteristic usually is covered by the severe tissue injury. When exposure to infrasound is stopped for a period of time, the local tissue injury of the adrenal cortex zona fasciculation could recovers at certain extent, but the higher the exposure sound pressure level, the more poorer the tissue recovery.

29 CFR 776.16 - Employment in “producing, * * * or in any other manner working on” goods.

Code of Federal Regulations, 2014 CFR

2014-07-01

.... Friend, 156 F. 2d 429 (C.A. 8); Walling v. Commet Carriers, 151 F. 2d 107 (C.A. 2); Phillips v. Star Overall Dry Cleaning Laundry Co., 149 F. 2d 416 (C.A. 2); certiorari denied 327 U.S. 780; Walling v. Griffin Cartage Co., 62 F. Supp. 396, affirmed in 153 F. 2d 587 (C.A. 6). For examples, see paragraphs (c...

29 CFR 776.16 - Employment in “producing, * * * or in any other manner working on” goods.

Code of Federal Regulations, 2013 CFR

2013-07-01

.... Friend, 156 F. 2d 429 (C.A. 8); Walling v. Commet Carriers, 151 F. 2d 107 (C.A. 2); Phillips v. Star Overall Dry Cleaning Laundry Co., 149 F. 2d 416 (C.A. 2); certiorari denied 327 U.S. 780; Walling v. Griffin Cartage Co., 62 F. Supp. 396, affirmed in 153 F. 2d 587 (C.A. 6). For examples, see paragraphs (c...

29 CFR 776.16 - Employment in “producing, * * * or in any other manner working on” goods.

Code of Federal Regulations, 2012 CFR

2012-07-01

.... Friend, 156 F. 2d 429 (C.A. 8); Walling v. Commet Carriers, 151 F. 2d 107 (C.A. 2); Phillips v. Star Overall Dry Cleaning Laundry Co., 149 F. 2d 416 (C.A. 2); certiorari denied 327 U.S. 780; Walling v. Griffin Cartage Co., 62 F. Supp. 396, affirmed in 153 F. 2d 587 (C.A. 6). For examples, see paragraphs (c...

MILSTRIP. MILitary, STandard, Requisitioning and Issue Procedures.

DTIC Science & Technology

1987-05-01

Reduction in the Use of Exception Data Requisitions (Staffed by PMCL 483A), fully implements the use of Status Code D6 under chapter 2 and appendix B16 ...and appendices BI, B16 , C4, and C17. (1 Nov 92) C. AMCL 16, Revised Dollar Threshold for Shipment Status (DI AS3) to DRMS (Staffed by PMCL 13A...and appendices Bi, B16 , and C46, and adds new appendix A34. (1 Nov 92) F. AMCL 165A, Status Codes for Nonconsumable Items (Staffed by PMCL 478

Six cytotoxic annonaceous acetogenins from Annona squamosa seeds.

PubMed

Chen, Yong; Chen, Jian-Wei; Wang, Yu; Xu, Sha-Sha; Li, Xiang

2012-12-01

Custard apple (Annona squamosa L.) is an edible tropical fruit, and its seeds had been used in south China as a folk medicine to treat "malignant sore" (cancer) and as an insecticide. Phytochemical investigation of the ethanol fraction of custard apple seeds led to the isolation of six new annonaceous acetogenins: annosquacins A-D (1-4), annosquatin A (5) and annosquatin B (6). Their structures were elucidated by spectroscopic analysis. Compounds 1-4 are adjacent bistetrahydrofuran annonaceous acetogenins. Compounds 5 and 6 are non-adjacent bistetrahydrofuran annonaceous acetogenins and the first examples in which the tetrahydrofuran ring system is located between C-9 and C-20. The absolute configurations of 1-6 were defined by the application of the Mosher method. Compounds 1-6 exhibited potent cytotoxic activity in vitro against five human tumour cell lines. Compounds 5 and 6 showed a high selectivity toward the MCF-7 and A-549 cell line respectively. Copyright © 2012 Elsevier Ltd. All rights reserved.

Development of ultrasound focusing discrete array for air-coupled ultrasound generation

NASA Astrophysics Data System (ADS)

Korobov, Alexander I.; Izosimova, Maria Y.; Toschov, Sergey A.

2010-01-01

The technique and results of synthesis of ultrasound focusing discrete arrays for air-coupled ultrasound generation are presented. One of the arrays is an antenna 22 cm in diameter. It consists of 60 transmitters of Murata Company. The resonant frequency of each transmitter is 40 kHz, diameter is 16 mm. The transmitters were placed in first four Fresnel zones. Each of the zones was emitting with anti-phases. Position data and pressure field in focus were calculated using Rayleigh integral. Parameters of made array were measured using method of air-coupled vibrometry with laser scanning vibrometer. Measured parameters (operating frequency is 40 ± 1 kHz, focal distance is 308 mm, size of focal spot is 16.3 mm, and pressure in focus is about 150 dB) are in good agreement with calculated data. The examples of use of designed arrays for noncontact non-destructive diagnostics of some structural materials are reported. Work supported by RFBR.

Photothermal Deoxygenation of Graphene Oxide for Distributed Ignition and Patterning Applications (Postprint)

DTIC Science & Technology

2010-01-01

5] B. Brodie, Ann. Chim. Phys. 1855, 45, 351. [6] D. Dikin , S. Stankovich, E. J. Zimney, R. D. Piner, H. B. Dommett, G. Evmenenko, S. T. Nguyen, R. S... Dikin , R. D. Piner, K. A. Kohlhaas, A. Kleinhammes, Y. Jia, Y. Wu, S. T. Nguyen, R. S. Ruoff, Carbon 2007, 45, 1558. [9] S. Stankovich, R. D. Piner, X...Lett. 2007, 7, 3499. [16] S. Stankovich, D. A. Dikin , G. H. B. Dommett, K. M. Kohlhaas, E. J. Zimney, E. A. Stach, R. D. Piner, S. T. Nguyen, R. S

Multimedia Visualisation of Massive Military Datasets (Visualisation multimedia des jeux de donnees militaires massifs)

DTIC Science & Technology

2007-06-01

the Los Angeles Area A-16 Figure A-5 Illustration of the Life Cycle of the Japanese Beetle A-17 Figure B-1 Knowledge Wall B-8 Figure B-2...Structure of World Trade in 1992 C-15 Figure D-1 3D Panorama Cinema at CAVI in Use D-2 Figure D-2 Holobench at CAVI D-2 Figure D-3 Virtual Studio...Illustration of the Life Cycle of the Japanese Beetle. A.6 STEPS IN ESTABLISHING A THEORY OF EFFECTIVE VISUALISATION An established theory generally

16 CFR 301.22 - Disclosure of damaged furs.

Code of Federal Regulations, 2011 CFR

2011-01-01

... decrease the normal life and durability of such product. (b) When damaged furs are used in a fur product..., or advertising such product; as for example: Mink Fur origin: Canada Contains Damaged Fur ...

Loss of Activin Receptor Type 1B Accelerates Development of Intraductal Papillary Mucinous Neoplasms in Mice With Activated KRAS.

PubMed

Qiu, Wanglong; Tang, Sophia M; Lee, Sohyae; Turk, Andrew T; Sireci, Anthony N; Qiu, Anne; Rose, Christian; Xie, Chuangao; Kitajewski, Jan; Wen, Hui-Ju; Crawford, Howard C; Sims, Peter A; Hruban, Ralph H; Remotti, Helen E; Su, Gloria H

2016-01-01

Activin, a member of the transforming growth factor-β (TGFB) family, might be involved in pancreatic tumorigenesis, similar to other members of the TGFB family. Human pancreatic ductal adenocarcinomas contain somatic mutations in the activin A receptor type IB (ACVR1B) gene, indicating that ACVR1B could be a suppressor of pancreatic tumorigenesis. We disrupted Acvr1b specifically in pancreata of mice (Acvr1b(flox/flox);Pdx1-Cre mice) and crossed them with LSL-KRAS(G12D) mice, which express an activated form of KRAS and develop spontaneous pancreatic tumors. The resulting Acvr1b(flox/flox);LSL-KRAS(G12D);Pdx1-Cre mice were monitored; pancreatic tissues were collected and analyzed by histology and immunohistochemical analyses. We also analyzed p16(flox/flox);LSL-Kras(G12D);Pdx1-Cre mice and Cre-negative littermates (controls). Genomic DNA, total RNA, and protein were isolated from mouse tissues and primary pancreatic tumor cell lines and analyzed by reverse-transcription polymerase chain reaction, sequencing, and immunoblot analyses. Human intraductal papillary mucinous neoplasm (IPMN) specimens were analyzed by immunohistochemistry. Loss of ACVR1B from pancreata of mice increased the proliferation of pancreatic epithelial cells, led to formation of acinar to ductal metaplasia, and induced focal inflammatory changes compared with control mice. Disruption of Acvr1b in LSL-KRAS(G12D);Pdx1-Cre mice accelerated the growth of pancreatic IPMNs compared with LSL-KRAS(G12D);Pdx1-Cre mice, but did not alter growth of pancreatic intraepithelial neoplasias. We associated perinuclear localization of the activated NOTCH4 intracellular domain to the apical cytoplasm of neoplastic cells with the expansion of IPMN lesions in Acvr1b(flox/flox);LSL-KRAS(G12D);Pdx1-Cre mice. Loss of the gene that encodes p16 (Cdkn2a) was required for progression of IPMNs to pancreatic ductal adenocarcinomas in Acvr1b(flox/flox);LSL-Kras(G12D);Pdx1-Cre mice. We also observed progressive loss of p16 in human IPMNs of increasing grades. Loss of ACVR1B accelerates growth of mutant KRAS-induced pancreatic IPMNs in mice; this process appears to involve NOTCH4 and loss of p16. ACVR1B suppresses early stages of pancreatic tumorigenesis; the activin signaling pathway therefore might be a therapeutic target for pancreatic cancer. Copyright © 2016 AGA Institute. Published by Elsevier Inc. All rights reserved.

Importance of interferon alpha in the resistance of allogeneic C57B1/6 mice to the multiplication of Friend erythroleukemia cells in the liver.

PubMed

Gresser, I; Maury, C; Bandu, M T; Belardelli, F

1990-02-15

Friend erythroleukemia cells (FLC) (H-2d) injected intravenously multiply extensively in the livers of syngeneic DBA/2 mice and not at all in the livers of allogeneic C57B1/6 mice. Our results indicate that interferon alpha (IFN-alpha) is an important factor in the resistance of allogeneic mice to the multiplication of FLC in the liver. (a) After i.v. inoculation of FLC there was an inverse correlation between the presence of IFN-alpha in the serum and the capacity of FLC to multiply in the liver. Thus, all 44 FLC-injected adult C57B1/6 mice had circulating IFN-alpha and FLC did not multiply in the liver of any of the mice. Interferon was not detected in the serum of 83% of 41 FLC-injected DBA/2 mice (and was found only at a low titer in 17% of the mice) and FLC multiplied in the liver of all mice. (b) FLC did multiply in the livers of newborn C57B1/6 mice and in the livers of irradiated adult C57B1/6 mice, and IFN-alpha was not detected in their sera. In contrast, after i.v. inoculation of FLC, IFN-alpha was detected in the sera of 3-week-old and athymic nu/nu adult C57B1/6 mice while FLC failed to multiply in the liver. (c) FLC also induced IFN-alpha in congenic B10.D2 (H-2d) mice and FLC did not multiply in the liver. We suggest that, depending on the site of tumor implantation, different host mechanisms have various degrees of importance in controlling the growth and/or rejection of allogeneic tumor cells, and that IFN-alpha is particularly important when FLC are injected i.v.

Selective 2-( sup 18 F)fluorodopa uptake for melanogenesis in murine metastatic melanomas

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ishiwata, K.; Kubota, K.; Kubota, R.

The relationship between 3,4-dihydroxy-2-({sup 18}F)fluoro-L-phenylalanine (2-({sup 18}F)FDOPA) uptake and melanogenesis was studied using mice bearing two B16 melanomas: B16-F1 has a higher melanin synthesis ability and a slower growing rate than the higher metastatic B16-F10. A significantly higher 2-({sup 18}F)FDOPA uptake by B16-F1 than by B16-F10 and a reverse relationship for the uptake of ({sup 14}C) 2-deoxy-2-fluoro-D-glucose and ({sup 3}H)thymidine were observed 1 hr postinjection. F1-to-F10 ratios of both the 2-({sup 18}F)FDOPA uptake and the acid-insoluble radioactivity increased to about 5 at 6 hr, which paralleled the melanin content. FM3A mammary carcinoma showed a 2-({sup 18}F)FDOPA uptake similar to themore » B16-F10 but without the acid-insoluble radioactivity. With D,L-DOPA loading, a 55% decreased uptake by FM3A 1 hr postinjection was significantly greater than the 20% reduction in both melanomas. O-Methylated 2-({sup 18}F)FDOPA was a predominant acid-soluble metabolite in all tumors. Whole-body autoradiography discriminated the two melanomas clearly. 2-({sup 18}F)FDOPA may be a promising tracer for the selective imaging of melanogenesis.« less

Multi-wavelength transceiver integration on SOI for high-performance computing system applications

NASA Astrophysics Data System (ADS)

Aalto, Timo; Harjanne, Mikko; Ylinen, Sami; Kapulainen, Markku; Vehmas, Tapani; Cherchi, Matteo; Neumeyr, Christian; Ortsiefer, Markus; Malacarne, Antonio

2015-03-01

We present a vision for transceiver integration on a 3 μm SOI waveguide platform for systems scalable to Pb/s. We also present experimental results from the first building blocks developed in the EU-funded RAPIDO project. At 1.3 μm wavelength 80 Gb/s per wavelength is to be achieved using hybrid integration of III-V optoelectronics on SOI. Goals include athermal operation, low-loss I/O coupling, advanced modulation formats and packet switching. An example of the design results is an interposer chip that consists of 12 μm thick SOI waveguides locally tapered down to 3 μm to provide low-loss coupling between an optical single-mode fiber array and the 3 μm SOI chip. First example of experimental results is a 4x4 cyclic AWGs with 5 nm channel spacing, 0.4 dB/facet fiber coupling loss, 3.5 dB center-tocenter loss, and -23 dB adjacent channel crosstalk in 3.5x1.5 mm2 footprint. The second example result is a new VCSEL design that was demonstrated to have up to 40 Gb/s operation at 1.55 μm.

16 CFR 1500.87 - Children's products containing lead: inaccessible component parts.

Code of Federal Regulations, 2010 CFR

2010-01-01

... child. (c) Section 101(b)(2)(B) of the CPSIA directs the Commission to promulgate by August 14, 2009... components will be considered to be inaccessible. (d) The accessibility probes specified for sharp points or... regulations at 16 CFR 1500.50 and 16 CFR 1500.51 (excluding the bite test of § 1500.51(c)), will be used to...

Mode-Division-Multiplexing of Multiple Bessel-Gaussian Beams Carrying Orbital-Angular-Momentum for Obstruction-Tolerant Free-Space Optical and Millimetre-Wave Communication Links.

PubMed

Ahmed, Nisar; Zhao, Zhe; Li, Long; Huang, Hao; Lavery, Martin P J; Liao, Peicheng; Yan, Yan; Wang, Zhe; Xie, Guodong; Ren, Yongxiong; Almaiman, Ahmed; Willner, Asher J; Ashrafi, Solyman; Molisch, Andreas F; Tur, Moshe; Willner, Alan E

2016-03-01

We experimentally investigate the potential of using 'self-healing' Bessel-Gaussian beams carrying orbital-angular-momentum to overcome limitations in obstructed free-space optical and 28-GHz millimetre-wave communication links. We multiplex and transmit two beams (l = +1 and +3) over 1.4 metres in both the optical and millimetre-wave domains. Each optical beam carried 50-Gbaud quadrature-phase-shift-keyed data, and each millimetre-wave beam carried 1-Gbaud 16-quadrature-amplitude-modulated data. In both types of links, opaque disks of different sizes are used to obstruct the beams at different transverse positions. We observe self-healing after the obstructions, and assess crosstalk and power penalty when data is transmitted. Moreover, we show that Bessel-Gaussian orbital-angular-momentum beams are more tolerant to obstructions than non-Bessel orbital-angular-momentum beams. For example, when obstructions that are 1 and 0.44 the size of the l = +1 beam, are placed at beam centre, optical and millimetre-wave Bessel-Gaussian beams show ~6 dB and ~8 dB reduction in crosstalk, respectively.

Mode-Division-Multiplexing of Multiple Bessel-Gaussian Beams Carrying Orbital-Angular-Momentum for Obstruction-Tolerant Free-Space Optical and Millimetre-Wave Communication Links

PubMed Central

Ahmed, Nisar; Zhao, Zhe; Li, Long; Huang, Hao; Lavery, Martin P. J.; Liao, Peicheng; Yan, Yan; Wang, Zhe; Xie, Guodong; Ren, Yongxiong; Almaiman, Ahmed; Willner, Asher J.; Ashrafi, Solyman; Molisch, Andreas F.; Tur, Moshe; Willner, Alan E.

2016-01-01

We experimentally investigate the potential of using ‘self-healing’ Bessel-Gaussian beams carrying orbital-angular-momentum to overcome limitations in obstructed free-space optical and 28-GHz millimetre-wave communication links. We multiplex and transmit two beams (l = +1 and +3) over 1.4 metres in both the optical and millimetre-wave domains. Each optical beam carried 50-Gbaud quadrature-phase-shift-keyed data, and each millimetre-wave beam carried 1-Gbaud 16-quadrature-amplitude-modulated data. In both types of links, opaque disks of different sizes are used to obstruct the beams at different transverse positions. We observe self-healing after the obstructions, and assess crosstalk and power penalty when data is transmitted. Moreover, we show that Bessel-Gaussian orbital-angular-momentum beams are more tolerant to obstructions than non-Bessel orbital-angular-momentum beams. For example, when obstructions that are 1 and 0.44 the size of the l = +1 beam, are placed at beam centre, optical and millimetre-wave Bessel-Gaussian beams show ~6 dB and ~8 dB reduction in crosstalk, respectively. PMID:26926068

Acoustic Propagation in the Labrador Sea

DTIC Science & Technology

1977-03-08

Difference a Number of Significance-Test D - S. (dB) (dB) Samples Results IA 3.5 1.2 19 Significant lB 25 1.6 146 Significant IC 1.4 1.9 78 Probably...extrapolated value to 914 m from Fig- 2 is 83 dBpfaIHz.. A Labrador Sea ambient-noise value of $6 dBlPaIHz was reported in Ref- 9 for the open ocean under...shot tracks rwill be discussed in a generally counterclockwise order starting with lB . All of the data given are with reference to the 18.3-m-deep source

47 CFR 80.207 - Classes of emission.

Code of Federal Regulations, 2013 CFR

2013-10-01

... radiotelephone and radiotelegraph emissions by ship and coast stations includes the use of digital selective... power; (B) For ship station transmitters installed before January 2, 1982, 16±2 dB below peak envelope power; and (C) For ship station transmitters installed after January 1, 1982, 18±2 dB below peak...

47 CFR 80.207 - Classes of emission.

Code of Federal Regulations, 2012 CFR

2012-10-01

... radiotelephone and radiotelegraph emissions by ship and coast stations includes the use of digital selective... power; (B) For ship station transmitters installed before January 2, 1982, 16±2 dB below peak envelope power; and (C) For ship station transmitters installed after January 1, 1982, 18±2 dB below peak...

Genes in FRA16D and FRA7G Mutated in Prostate Cancer.

DTIC Science & Technology

1999-06-01

Huang H, Nelson M , Smith DI. Cloning and characterization of keratin 21 (K21) highly induced by histone deacetylase inhibitors during differentiation...A395. Kawakami M , Hartmann L, Huntley B, Smith DI, Shridhar V. Allele loss on 16q in high-grade invasive epithelial ovarian cancer. Amer. J. Hum...CEN m N CO o < 1 WC7.7 I-- CD co r-- Q CO CO CD CO Q _L_ 921B4 912D9 _1_ 887 D11 WC7.6 A GAP BETWEEN YAC CONTIGS tu O CD

Measurement of the branching fractions of exclusive _B-->D(*)(pi)l-_nu l decays in events with a fully reconstructed B meson.

PubMed

Aubert, B; Bona, M; Karyotakis, Y; Lees, J P; Poireau, V; Prudent, X; Tisserand, V; Zghiche, A; Garra Tico, J; Grauges, E; Lopez, L; Palano, A; Pappagallo, M; Eigen, G; Stugu, B; Sun, L; Abrams, G S; Battaglia, M; Brown, D N; Button-Shafer, J; Cahn, R N; Jacobsen, R G; Kadyk, J A; Kerth, L T; Kolomensky, Yu G; Kukartsev, G; Lynch, G; Osipenkov, I L; Ronan, M T; Tackmann, K; Tanabe, T; Wenzel, W A; del Amo Sanchez, P; Hawkes, C M; Soni, N; Watson, A T; Koch, H; Schroeder, T; Walker, D; Asgeirsson, D J; Cuhadar-Donszelmann, T; Fulsom, B G; Hearty, C; Mattison, T S; McKenna, J A; Barrett, M; Khan, A; Saleem, M; Teodorescu, L; Blinov, V E; Bukin, A D; Buzykaev, A R; Druzhinin, V P; Golubev, V B; Onuchin, A P; Serednyakov, S I; Skovpen, Yu I; Solodov, E P; Todyshev, K Yu; Bondioli, M; Curry, S; Eschrich, I; Kirkby, D; Lankford, A J; Lund, P; Mandelkern, M; Martin, E C; Stoker, D P; Abachi, S; Buchanan, C; Gary, J W; Liu, F; Long, O; Shen, B C; Vitug, G M; Yasin, Z; Zhang, L; Paar, H P; Rahatlou, S; Sharma, V; Campagnari, C; Hong, T M; Kovalskyi, D; Richman, J D; Beck, T W; Eisner, A M; Flacco, C J; Heusch, C A; Kroseberg, J; Lockman, W S; Schalk, T; Schumm, B A; Seiden, A; Wilson, M G; Winstrom, L O; Chen, E; Cheng, C H; Doll, D A; Echenard, B; Fang, F; Hitlin, D G; Narsky, I; Piatenko, T; Porter, F C; Andreassen, R; Mancinelli, G; Meadows, B T; Mishra, K; Sokoloff, M D; Blanc, F; Bloom, P C; Ford, W T; Hirschauer, J F; Kreisel, A; Nagel, M; Nauenberg, U; Olivas, A; Smith, J G; Ulmer, K A; Wagner, S R; Ayad, R; Gabareen, A M; Soffer, A; Toki, W H; Wilson, R J; Altenburg, D D; Feltresi, E; Hauke, A; Jasper, H; Karbach, M; Merkel, J; Petzold, A; Spaan, B; Wacker, K; Klose, V; Kobel, M J; Lacker, H M; Mader, W F; Nogowski, R; Schubert, J; Schubert, K R; Schwierz, R; Sundermann, J E; Volk, A; Bernard, D; Bonneaud, G R; Latour, E; Thiebaux, Ch; Verderi, M; Clark, P J; Gradl, W; Playfer, S; Robertson, A I; Watson, J E; Andreotti, M; Bettoni, D; Bozzi, C; Calabrese, R; Cecchi, A; Cibinetto, G; Franchini, P; Luppi, E; Negrini, M; Petrella, A; Piemontese, L; Prencipe, E; Santoro, V; Anulli, F; Baldini-Ferroli, R; Calcaterra, A; de Sangro, R; Finocchiaro, G; Pacetti, S; Patteri, P; Peruzzi, I M; Piccolo, M; Rama, M; Zallo, A; Buzzo, A; Contri, R; Lo Vetere, M; Macri, M M; Monge, M R; Passaggio, S; Patrignani, C; Robutti, E; Santroni, A; Tosi, S; Chaisanguanthum, K S; Morii, M; Dubitzky, R S; Marks, J; Schenk, S; Uwer, U; Bard, D J; Dauncey, P D; Nash, J A; Panduro Vazquez, W; Tibbetts, M; Behera, P K; Chai, X; Charles, M J; Mallik, U; Cochran, J; Crawley, H B; Dong, L; Eyges, V; Meyer, W T; Prell, S; Rosenberg, E I; Rubin, A E; Gao, Y Y; Gritsan, A V; Guo, Z J; Lae, C K; Denig, A G; Fritsch, M; Schott, G; Arnaud, N; Béquilleux, J; D'Orazio, A; Davier, M; Firmino da Costa, J; Grosdidier, G; Höcker, A; Lepeltier, V; Le Diberder, F; Lutz, A M; Pruvot, S; Roudeau, P; Schune, M H; Serrano, J; Sordini, V; Stocchi, A; Wang, W F; Wormser, G; Lange, D J; Wright, D M; Bingham, I; Burke, J P; Chavez, C A; Fry, J R; Gabathuler, E; Gamet, R; Hutchcroft, D E; Payne, D J; Touramanis, C; Bevan, A J; George, K A; Di Lodovico, F; Sacco, R; Sigamani, M; Cowan, G; Flaecher, H U; Hopkins, D A; Paramesvaran, S; Salvatore, F; Wren, A C; Brown, D N; Davis, C L; Alwyn, K E; Barlow, N R; Barlow, R J; Chia, Y M; Edgar, C L; Lafferty, G D; West, T J; Yi, J I; Anderson, J; Chen, C; Jawahery, A; Roberts, D A; Simi, G; Tuggle, J M; Dallapiccola, C; Hertzbach, S S; Li, X; Salvati, E; Saremi, S; Cowan, R; Dujmic, D; Fisher, P H; Koeneke, K; Sciolla, G; Spitznagel, M; Taylor, F; Yamamoto, R K; Zhao, M; McLachlin, S E; Patel, P M; Robertson, S H; Lazzaro, A; Lombardo, V; Palombo, F; Bauer, J M; Cremaldi, L; Eschenburg, V; Godang, R; Kroeger, R; Sanders, D A; Summers, D J; Zhao, H W; Brunet, S; Côté, D; Simard, M; Taras, P; Viaud, F B; Nicholson, H; De Nardo, G; Lista, L; Monorchio, D; Sciacca, C; Baak, M A; Raven, G; Snoek, H L; Jessop, C P; Knoepfel, K J; LoSecco, J M; Benelli, G; Corwin, L A; Honscheid, K; Kagan, H; Kass, R; Morris, J P; Rahimi, A M; Regensburger, J J; Sekula, S J; Wong, Q K; Blount, N L; Brau, J; Frey, R; Igonkina, O; Kolb, J A; Lu, M; Rahmat, R; Sinev, N B; Strom, D; Strube, J; Torrence, E; Castelli, G; Gagliardi, N; Gaz, A; Margoni, M; Morandin, M; Posocco, M; Rotondo, M; Simonetto, F; Stroili, R; Voci, C; Ben-Haim, E; Briand, H; Calderini, G; Chauveau, J; David, P; Del Buono, L; Hamon, O; Leruste, Ph; Malclès, J; Ocariz, J; Perez, A; Prendki, J; Gladney, L; Biasini, M; Covarelli, R; Manoni, E; Angelini, C; Batignani, G; Bettarini, S; Carpinelli, M; Cervelli, A; Forti, F; Giorgi, M A; Lusiani, A; Marchiori, G; Morganti, M; Mazur, M A; Neri, N; Paoloni, E; Rizzo, G; Walsh, J J; Biesiada, J; Lau, Y P; Lopes Pegna, D; Lu, C; Olsen, J; Smith, A J S; Telnov, A V; Baracchini, E; Cavoto, G; del Re, D; Di Marco, E; Faccini, R; Ferrarotto, F; Ferroni, F; Gaspero, M; Jackson, P D; Mazzoni, M A; Morganti, S; Piredda, G; Polci, F; Renga, F; Voena, C; Ebert, M; Hartmann, T; Schröder, H; Waldi, R; Adye, T; Franek, B; Olaiya, E O; Roethel, W; Wilson, F F; Emery, S; Escalier, M; Gaidot, A; Ganzhur, S F; Hamel de Monchenault, G; Kozanecki, W; Vasseur, G; Yèche, Ch; Zito, M; Chen, X R; Liu, H; Park, W; Purohit, M V; White, R M; Wilson, J R; Allen, M T; Aston, D; Bartoldus, R; Bechtle, P; Benitez, J F; Cenci, R; Coleman, J P; Convery, M R; Dingfelder, J C; Dorfan, J; Dubois-Felsmann, G P; Dunwoodie, W; Field, R C; Glanzman, T; Gowdy, S J; Graham, M T; Grenier, P; Hast, C; Innes, W R; Kaminski, J; Kelsey, M H; Kim, H; Kim, P; Kocian, M L; Leith, D W G S; Li, S; Lindquist, B; Luitz, S; Luth, V; Lynch, H L; MacFarlane, D B; Marsiske, H; Messner, R; Muller, D R; Neal, H; Nelson, S; O'Grady, C P; Ofte, I; Perazzo, A; Perl, M; Ratcliff, B N; Roodman, A; Salnikov, A A; Schindler, R H; Schwiening, J; Snyder, A; Su, D; Sullivan, M K; Suzuki, K; Swain, S K; Thompson, J M; Va'vra, J; Wagner, A P; Weaver, M; Wisniewski, W J; Wittgen, M; Wright, D H; Wulsin, H W; Yarritu, A K; Yi, K; Young, C C; Ziegler, V; Burchat, P R; Edwards, A J; Majewski, S A; Miyashita, T S; Petersen, B A; Wilden, L; Ahmed, S; Alam, M S; Bula, R; Ernst, J A; Pan, B; Saeed, M A; Zain, S B; Spanier, S M; Wogsland, B J; Eckmann, R; Ritchie, J L; Ruland, A M; Schilling, C J; Schwitters, R F; Izen, J M; Lou, X C; Ye, S; Bianchi, F; Gamba, D; Pelliccioni, M; Bomben, M; Bosisio, L; Cartaro, C; Cossutti, F; Della Ricca, G; Lanceri, L; Vitale, L; Azzolini, V; Lopez-March, N; Martinez-Vidal, F; Milanes, D A; Oyanguren, A; Albert, J; Banerjee, Sw; Bhuyan, B; Hamano, K; Kowalewski, R; Nugent, I M; Roney, J M; Sobie, R J; Gershon, T J; Harrison, P F; Ilic, J; Latham, T E; Mohanty, G B; Band, H R; Chen, X; Dasu, S; Flood, K T; Hollar, J J; Kutter, P E; Pan, Y; Pierini, M; Prepost, R; Vuosalo, C O; Wu, S L

2008-04-18

We report a measurement of the branching fractions for _B-->D(*)(pi)l- _nu(l) decays based on 341.1 fb(-1) of data collected at the Upsilon(4S) resonance with the BABAR detector at the SLAC PEP-II e+ e- storage rings. Events are tagged by fully reconstructing one of the B mesons in a hadronic decay mode. We obtain B(B- -->D(0)l-_nu(l)=(2.33+/-0.09(stat)+/-0.09(syst)%, B(B- -->D(*0)l-_nu(l)=(5.83+/-0.15(stat) +/-0.30(syst) %, B(_B(0)-->D+l-_nu(l)=(2.21+/-0.11(stat) +/-0.12(syst)%, B(_B(0)-->D(*)l-_nu(l)=(5.49+/-0.16(stat)+/-0.25(syst)%, B(B- -->D+pi-l-_nu(l)=(0.42+/-0.06(stat)+/-0.03(syst)%, B(B- -->D(*)+pi-l-_nu(l)=(0.59+/-0.05(stat)+/-0.04(syst)%, B(_B(0)-->D(0)pi+l-_nu(l)=(0.43+/-0.08(stat)+/-0.03(syst)%, and B(_B(0)-->D(*0)pi+l-_nu(l)=(0.48+/-0.08(stat)+/-0.04(syst)%.

Distribution of inhomogeneities in the interstellar plasma in the directions of three distant pulsars from observations with the RadioAstron ground-space interferometer

NASA Astrophysics Data System (ADS)

Popov, M. V.; Andrianov, A. S.; Bartel, N.; Gwinn, C.; Joshi, B. C.; Jauncey, D.; Kardashev, N. S.; Rudnitskii, A. G.; Smirnova, T. V.; Soglasnov, V. A.; Fadeev, E. N.; Shishov, V. I.

2016-09-01

The RadioAstron ground-space interferometer has been used to measure the angular sizes of the scattering disks of the three distant pulsars B1641-45, B1749-28, and B1933+16. The observations were carried out with the participation of the Westerbork Synthesis Radio Telescope; two 32-m telescopes at Torun, Poland and Svetloe, Russia (the latter being one antenna of the KVAZAR network); the Saint Croix VLBA antenna; the Arecibo radio telescope; the Parkes, Narrabri (ATCA), Mopra, Hobart, and Ceduna Australian radio telescopes; and the Hartebeesthoek radio telescope in South Africa. The full widths at half maximum of the scattering disks were 27 mas at 1668 MHz for B1641-45, 0.5 mas at 1668 MHz for B1749-28, and 12.3 at 316 MHz and 0.84 mas at 1668 MHz for B1933+16. The characteristic time scales for scatter-broadening of the pulses on inhomogeneities in the interstellar plasma τsc were also measured for these pulsars using various methods. Joint knowledge of the size of the scattering disk and the scatter-broadening time scale enables estimation of the distance to the effective scattering screen d. For B1641-45, d = 3.0 kpc for a distance to the pulsar D = 4.9 kpc, and for B1749-28, d = 0.95 kpc for D = 1.3 kpc. Observations of B1933+16 were carried out simultaneously at 316 and 1668 MHz. The positions of the screen derived using the measurements at the two frequencies agree: d 1 = 2.6 and d 2 = 2.7 kpc, for a distance to the pulsar of 3.7 kpc. Two screens were detected for this pulsar from an analysis of parabolic arcs in the secondary dynamic spectrum at 1668 MHz, at 1.3 and 3.1 kpc. The scattering screens for two of the pulsars are identified with real physical objects located along the lines of sight toward the pulsars: G339.1-04 (B1641-45) and G0.55-0.85 (B1749-28).

Antitumor activity of a novel anti-vascular endothelial growth factor receptor-1 monoclonal antibody that does not interfere with ligand binding

PubMed Central

Tentori, Lucio; Scimeca, Manuel; Dorio, Annalisa S.; Atzori, Maria Grazia; Failla, Cristina M.; Morea, Veronica; Bonanno, Elena; D'Atri, Stefania; Lacal, Pedro M.

2016-01-01

Vascular endothelial growth factor receptor-1 (VEGFR-1) is a tyrosine kinase transmembrane receptor that has also a soluble isoform containing most of the extracellular ligand binding domain (sVEGFR-1). VEGF-A binds to both VEGFR-2 and VEGFR-1, whereas placenta growth factor (PlGF) interacts exclusively with VEGFR-1. In this study we generated an anti-VEGFR-1 mAb (D16F7) by immunizing BALB/C mice with a peptide that we had previously reported to inhibit angiogenesis and endothelial cell migration induced by PlGF. D16F7 did not affect binding of VEGF-A or PlGF to VEGFR-1, thus allowing sVEGFR-1 to act as decoy receptor for these growth factors, but it hampered receptor homodimerization and activation. D16F7 inhibited both the chemotactic response of human endothelial, myelomonocytic and melanoma cells to VEGFR-1 ligands and vasculogenic mimicry by tumor cells. Moreover, D16F7 exerted in vivo antiangiogenic effects in a matrigel plug assay. Importantly, D16F7 inhibited tumor growth and was well tolerated by B6D2F1 mice injected with syngeneic B16F10 melanoma cells. The antitumor effect was associated with melanoma cell apoptosis, vascular abnormalities and decrease of both monocyte/macrophage infiltration and myeloid progenitor mobilization. For all the above, D16F7 may be exploited in the therapy of metastatic melanoma and other tumors or pathological conditions involving VEGFR-1 activation. PMID:27655684

Interface Design Description for the Multi-Mode Magnetic Detection System

DTIC Science & Technology

2008-11-21

400001E D/A Spare H 16 0000 48 4000020 PWM Piezo A 16 6230 Formatted Table 3MDS IDD 0BSB2-03-C-0388-01 Rev I 24 21 November 2008 Relative Base...Address (bytes) FPGA Address Item Size (bits) Definition Units/LSB Value/Other 50 4000022 PWM Piezo B 16 6230 52 4000024 PWM Piezo C 16...6230 54 4000026 PWM Piezo D 16 6230 56 4000028 PWM Piezo E 16 6230 58 400002A PWM Piezo F 16 6230 60 400002C Set the starting place for temp sweep 16

Development of the Russian matrix sentence test.

PubMed

Warzybok, Anna; Zokoll, Melanie; Wardenga, Nina; Ozimek, Edward; Boboshko, Maria; Kollmeier, Birger

2015-01-01

To develop the Russian matrix sentence test for speech intelligibility measurements in noise. Test development included recordings, optimization of speech material, and evaluation to investigate the equivalency of the test lists and training. For each of the 500 test items, the speech intelligibility function, speech reception threshold (SRT: signal-to-noise ratio, SNR, that provides 50% speech intelligibility), and slope was obtained. The speech material was homogenized by applying level corrections. In evaluation measurements, speech intelligibility was measured at two fixed SNRs to compare list-specific intelligibility functions. To investigate the training effect and establish reference data, speech intelligibility was measured adaptively. Overall, 77 normal-hearing native Russian listeners. The optimization procedure decreased the spread in SRTs across words from 2.8 to 0.6 dB. Evaluation measurements confirmed that the 16 test lists were equivalent, with a mean SRT of -9.5 ± 0.2 dB and a slope of 13.8 ± 1.6%/dB. The reference SRT, -8.8 ± 0.8 dB for the open-set and -9.4 ± 0.8 dB for the closed-set format, increased slightly for noise levels above 75 dB SPL. The Russian matrix sentence test is suitable for accurate and reliable speech intelligibility measurements in noise.

Dosimetric quality, accuracy, and deliverability of modulated radiotherapy treatments for spinal metastases

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kairn, Tanya, E-mail: t.kairn@gmail.com; School of Chemistry, Physics, and Mechanical Engineering, Queensland University of Technology, Brisbane; Papworth, Daniel

2016-10-01

Cancer often metastasizes to the vertebra, and such metastases can be treated successfully using simple, static posterior or opposed-pair radiation fields. However, in some cases, including when re-irradiation is required, spinal cord avoidance becomes necessary and more complex treatment plans must be used. This study evaluated 16 sample intensity-modulated radiation therapy (IMRT) and volumetric-modulated arc therapy (VMAT) treatment plans designed to treat 6 typical vertebral and paraspinal volumes using a standard prescription, with the aim of investigating the advantages and limitations of these treatment techniques and providing recommendations for their optimal use in vertebral treatments. Treatment plan quality and beammore » complexity metrics were evaluated using the Treatment And Dose Assessor (TADA) code. A portal-imaging–based quality assurance (QA) system was used to evaluate treatment delivery accuracy, and radiochromic film measurements were used to provide high-resolution verification of treatment plan dose accuracy, especially in the steep dose gradient regions between each vertebral target and spinal cord. All treatment modalities delivered approximately the same doses and the same levels of dose heterogeneity to each planning target volume (PTV), although the minimum PTV doses in the vertebral plans were substantially lower than the prescription, because of the requirement that the plans meet a strict constraint on the dose to the spinal cord and cord planning risk volume (PRV). All plans met required dose constraints on all organs at risk, and all measured PTV-cord dose gradients were steeper than planned. Beam complexity analysis suggested that the IMRT treatment plans were more deliverable (less complex, leading to greater QA success) than the VMAT treatment plans, although the IMRT plans also took more time to deliver. The accuracy and deliverability of VMAT treatment plans were found to be substantially increased by limiting the number of monitor units (MU) per beam at the optimization stage, and thereby limiting beam modulation complexity. The VMAT arcs that were optimized with MU limitation had higher QA pass rates as well as higher modulation complexity scores (less complexity), lower modulation indices (less modulation), lower MU per beam, larger beam segments, and fewer small apertures than the VMAT arcs that were optimized without MU limitation. It is recommended that VMAT treatments for vertebral volumes, where the PTV abuts or surrounds the spinal cord, should be optimized with MU limitation. IMRT treatments may be preferable to the VMAT treatments, for dosimetry and deliverability reasons, but may be inappropriate for some patients because of their increased treatment delivery time.« less

The First Example of an Organogallium Compound Containing a Ga-Te Bond: Synthesis, Properties and Molecular Structure of ((Me3CCH2)2GaTePh)2

DTIC Science & Technology

1989-06-12

Government *This document has been approved for public release and sale ; its distribution is unlimited S v r DL/1113/89/1 TECHNICAL REPORT DISTRIBUTION LIST...thermal parameter defined as (4/3) (a2B(1,1) + b2B (2,2) + c 2B(3,3) + ab(cos Y)B(1,2) + ac(cos B)B(1,3) + bc(cos a)B(2,3)]. -16- Captions for Figures

Lattice QCD and the unitarity triangle

DOE Office of Scientific and Technical Information (OSTI.GOV)

Andreas S Kronfeld

2001-12-03

Theoretical and computational advances in lattice calculations are reviewed, with focus on examples relevant to the unitarity triangle of the CKM matrix. Recent progress in semi-leptonic form factors for B {yields} {pi}/v and B {yields} D*lv, as well as the parameter {zeta} in B{sup 0}-{bar B}{sup 0} mixing, are highlighted.

DOE Office of Scientific and Technical Information (OSTI.GOV)

None, None

The multi-agent system (MAS) approach has been applied with promising results for enhancing an electric power distribution circuit, such as the Circuit of the Future as developed by Southern California Edison. These next generation power system results include better ability to reconfigure the circuit as well as the increased capability to improve the protection and enhance the reliability of the circuit. There were four main tasks in this project. The specific results for each of these four tasks and their related topics are presented in main sections of this report. Also, there were seven deliverables for this project. The mainmore » conclusions for these deliverables are summarized in the identified subtask section of this report. The specific details for each of these deliverables are included in the “Project Deliverables” section at the end of this Final Report.« less

Development of a FDA-Approved Pharmaceutical to Treat Noise-Induced Hearing Loss

DTIC Science & Technology

2014-08-13

be reduced by 40 dB, resulting in a 115 dB SPL of noise exposure for personnel servicing the flight operations. (5) BODY: Scientific and Technical...80 . 70 . Zklh ! 60 i - 41oHz 81611 16KH.I i 50 ·-·-----~~---- ! 40 l i JO • 1 zo ------------ 10 0 Z IoHz 41oHz 81oHz 16KHz...15•0/0I ~ 40 \\-- •• -----~r-----/----- -n-151131!0/JOOJ ! JO : 1 zo ’------~~--------- 10 0 1 IoHz 41oHz 8IoHz 16KHz 2 Main Effect: • • • -+-(S.0

26 CFR 601.201 - Rulings and determinations letters.

Code of Federal Regulations, 2010 CFR

2010-04-01

... entire group. See, for example, Rev. Proc. 78-15, 1978-2 C.B. 488, and Rev. Proc. 78-16, 1978-2 C.B. 489... rulings to business, trade, or industrial associations or to other similar groups relating to the application of the tax laws to members of the group. However, rulings may be issued to such groups or...

26 CFR 601.201 - Rulings and determinations letters.

Code of Federal Regulations, 2011 CFR

2011-04-01

... entire group. See, for example, Rev. Proc. 78-15, 1978-2 C.B. 488, and Rev. Proc. 78-16, 1978-2 C.B. 489... rulings to business, trade, or industrial associations or to other similar groups relating to the application of the tax laws to members of the group. However, rulings may be issued to such groups or...

26 CFR 601.201 - Rulings and determinations letters.

Code of Federal Regulations, 2014 CFR

2014-04-01

... entire group. See, for example, Rev. Proc. 78-15, 1978-2 C.B. 488, and Rev. Proc. 78-16, 1978-2 C.B. 489... rulings to business, trade, or industrial associations or to other similar groups relating to the application of the tax laws to members of the group. However, rulings may be issued to such groups or...

26 CFR 601.201 - Rulings and determinations letters.

Code of Federal Regulations, 2013 CFR

2013-04-01

... entire group. See, for example, Rev. Proc. 78-15, 1978-2 C.B. 488, and Rev. Proc. 78-16, 1978-2 C.B. 489... rulings to business, trade, or industrial associations or to other similar groups relating to the application of the tax laws to members of the group. However, rulings may be issued to such groups or...

26 CFR 601.201 - Rulings and determinations letters.

Code of Federal Regulations, 2012 CFR

2012-04-01

... entire group. See, for example, Rev. Proc. 78-15, 1978-2 C.B. 488, and Rev. Proc. 78-16, 1978-2 C.B. 489... rulings to business, trade, or industrial associations or to other similar groups relating to the application of the tax laws to members of the group. However, rulings may be issued to such groups or...

Measurement of the branching ratio of B ¯ 0 → D * + τ - ν ¯ τ relative to B ¯ 0 → D * + ℓ - ν ¯ ℓ decays with a semileptonic tagging method

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sato, Y.; Iijima, T.; Adamczyk, K.

We report a measurement of the ratio R(D*) = B(more » $$\\bar{B}$$ 0→ D *+τ -$$\\bar{v}$$τ )/B($$\\bar{B}$$ 0→D *+ℓ -$$\\bar{v}$$ℓ), where ℓ denotes an electron or a muon. The results are based on a data sample containing 772 × 10 6 B$$\\bar{B}$$ pairs recorded at the (4S) resonance with the Belle detector at the KEKB e +e - collider. We select a sample of B 0 $$\\bar{B}$$ 0pairs by reconstructing both B mesons in semileptonic decays to D *∓ℓ ±. We measure R(D*) = 0.302±0.030(stat) ±0.011(syst), which is within 1.6σ of the Standard Model theoretical expectation, where the standard deviation σ includes systematic uncertainties. We use this measurement to constrain several scenarios of new physics in a model-independent approach.« less

Biological Insights of the Dopaminergic Stabilizer ACR16 at the Binding Pocket of Dopamine D2 Receptor.

PubMed

Ekhteiari Salmas, Ramin; Seeman, Philip; Aksoydan, Busecan; Stein, Matthias; Yurtsever, Mine; Durdagi, Serdar

2017-04-19

The dopamine D2 receptor (D2R) plays an important part in the human central nervous system and it is considered to be a focal target of antipsychotic agents. It is structurally modeled in active and inactive states, in which homodimerization reaction of the D2R monomers is also applied. The ASP2314 (also known as ACR16) ligand, a D2R stabilizer, is used in tests to evaluate how dimerization and conformational changes may alter the ligand binding space and to provide information on alterations in inhibitory mechanisms upon activation. The administration of the D2R agonist ligand ACR16 [ 3 H](+)-4-propyl-3,4,4a,5,6,10b-hexahydro-2H-naphtho[1,2-b][1,4]oxazin-9-ol ((+)PHNO) revealed K i values of 32 nM for the D2 high R and 52 μM for the D2 low R. The calculated binding affinities of ACR16 with post processing molecular dynamics (MD) simulations analyses using MM/PBSA for the monomeric and homodimeric forms of the D2 high R were -9.46 and -8.39 kcal/mol, respectively. The data suggests that the dimerization of the D2R leads negative cooperativity for ACR16 binding. The dimerization reaction of the D2 high R is energetically favorable by -22.95 kcal/mol. The dimerization reaction structurally and thermodynamically stabilizes the D2 high R conformation, which may be due to the intermolecular forces formed between the TM4 of each monomer, and the result strongly demonstrates dimerization essential for activation of the D2R.

76 FR 56130 - Approval and Promulgation of Air Quality Implementation Plans; Maryland; Section 110(a)(2...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-12

... NAAQS dated October 22, 2008: 110(a)(2)(A), (B), (C), (D)(ii), (E), (F), (G), (H), (J), (K), (L), and (M...), (B), (C), (D)(ii), (E), (F), (G), (H), (J), (K), (L), and (M), or portions thereof. DATES: Written..., K, L, M. November 30, 2007 G April 3, 2008 A, B, C, D(ii), E, F, G, H, J, K, L, M. April 16, 2010 G...

Tri-Lab Co-Design Milestone: In-Depth Performance Portability Analysis of Improved Integrated Codes on Advanced Architecture.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hoekstra, Robert J.; Hammond, Simon David; Richards, David

2017-09-01

This milestone is a tri-lab deliverable supporting ongoing Co-Design efforts impacting applications in the Integrated Codes (IC) program element Advanced Technology Development and Mitigation (ATDM) program element. In FY14, the trilabs looked at porting proxy application to technologies of interest for ATS procurements. In FY15, a milestone was completed evaluating proxy applications in multiple programming models and in FY16, a milestone was completed focusing on the migration of lessons learned back into production code development. This year, the co-design milestone focuses on extracting the knowledge gained and/or code revisions back into production applications.

The emission in the region E>0.1MeV during disk and limb faint solar flares

NASA Astrophysics Data System (ADS)

Irene, Arkhangelskaja; Andrew, Arkhangelskiy; Yury, Kotov; Alexandr, Glyanenko; Maria, Kolchina; Alexey, Kirichenko

2013-06-01

Hard X-ray and gamma-ray emission in energy band E>50 keV was first observed by AVS-F apparatus onboard CORONAS-F satellite (detector SONG-D) during some solar flares with classes B and C by GOES classification. Such component registered in flares with duration less than 30 min. However γ-emission up to several tens of MeV was observed during some classes B and C events, which temporal profiles were not corresponded to Neupert effect. For example, during class B2.3 limb solar flare January 7, 2005 maximum observed energy was Emax˜36 MeV and during class B4.6 disk solar event January 12, 2005 maximum observed energy was Emax˜7 MeV. Properties of temporal profiles and energy spectra of faint solar flares, during which emission in the energy band of E>0.1 MeV were registered are discussed in the presented work. There is not any strong correlation between presence or absence of hard X-ray and γ-ray emission and the intensity of soft X-ray emission during solar flares. The one of illustration of this fact is the absence of any observed statistically significant count rate exceed above background level during some class M flares in the energy band E>0.1 MeV. The typical example of such flares is event November 8, 2001 (class M4.2, lasts from 14:59 UT up to 16:00 UT, maximum of soft X-ray emission was at 15:35 UT on GOES data).

26 CFR 26.2600-1 - Table of contents.

Code of Federal Regulations, 2010 CFR

2010-04-01

... lead annuity trusts. (a) In general. (b) Adjusted GST exemption defined. (c) Example. § 26.2642.... (b) Other GSTs. § 26.2642-6 Qualified severance. (a) In general. (b) Qualified severance defined. (c) Effective date of qualified severance. (d) Requirements for a qualified severance. (e) Reporting a qualified...

26 CFR 26.2600-1 - Table of contents.

Code of Federal Regulations, 2011 CFR

2011-04-01

... lead annuity trusts. (a) In general. (b) Adjusted GST exemption defined. (c) Example. § 26.2642.... (b) Other GSTs. § 26.2642-6 Qualified severance. (a) In general. (b) Qualified severance defined. (c) Effective date of qualified severance. (d) Requirements for a qualified severance. (e) Reporting a qualified...

78 FR 7835 - Self-Regulatory Organizations; BOX Options Exchange LLC; Notice of Filing of Proposed Rule Change...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-04

... at $145 per share would carry a total deliverable value of $145,000, and the strike price would be... Jumbo option strike price of $145 was trading at $146 per share, the intrinsic $1 per share value would... Shares Deliverable Upon Exercise 100 shares........ 1,000 shares Strike Price if underlying is 45 45 $45...

Coherent optical WDM systems for 1.6 Tb/s Ethernet over 40 km of single-mode fiber

NASA Astrophysics Data System (ADS)

Torres-Ferrera, P.; García-Yáñez, M. A.; Gutiérrez-Castrejón, R.; Tomkos, I.

2018-07-01

Two 1.6 Tb/s coherent optical wavelength division multiplexed (WDM) systems targeting inter-data center links of up to 40-km reach over conventional single-mode fiber (CSMF) on C-band are proposed and numerically analyzed: a DP-QPSK-based 16 × 112 Gb/s system and a DP-16-QAM-based 8 × 224 Gb/s system. To satisfy the metro access space, noise and power transceiver characteristics are optimized, avoiding the use of any type of optical amplification or forward-error correction (FEC) scheme. Accordingly to the current Ethernet standard, feasibility of both 28 GBd architectures is hence numerically demonstrated at a very low bit-error-ratio (BER) threshold of 1 × 10-13, uncovering power sensitivities of -26.0 and -13.5 dBm and optical signal-to-noise ratio (OSNR) sensitivities of 35 and 40 dB for the first and second architectures, respectively. Negligible transmission OSNR and power penalties with respect to the back-to-back (BtB) case are calculated, thus demonstrating the effectiveness of the utilized DSP algorithms. Our simulation work also confirms that the 16-QAM-based scheme is more demanding in terms of OSNR and transmission power specifications than the 16-channel one, requiring approximately 12 dB more power and 5 dB more OSNR level at the transmitter laser outputs, with similar requirements at the receiver end. It is also demonstrated that laser linewidths of at most 1 MHz should be specified in both architectures, that the transmitter laser characteristics play a more appreciable role than those of the receiver laser, and that the frequency offset between these two lasers should be kept below 3 GHz. Our research work leverages the use of optical coherent technology at metro network level and claims for a necessary technological upgrade to such schemes for a forthcoming 1.6 Tb/s Ethernet standard to be feasible.

[Effects of infrasound on ultrastructure of testis cell in mice].

PubMed

Wei, Ya-Ning; Liu, Jing; Shu, Qing; Huang, Xiao-Feng; Chen, Jing-Zao

2002-01-01

To investigate the effects of infrasound on ultrastructure of testis in mouse. Twelve male BALB/C mice were randomly divided into three groups according to exposed duration on 1, 7 and 14 day. The mice were separately exposed to infrasound environment under 8 Hz/90 dB, 8 Hz/130 dB, 16 Hz/90 dB, 16 Hz/130 dB 2 hours per day. There was another control group which had three mice were separated into module with no infrasound. All the mice were killed on schedule. Then all the sections of testis were observed under electronic microscope. The alterations of structure and the chromatin were observed. Some acute alteration in one day group was found in testis cell, such as cellular denaturation and necrosis, intercellular edema, mitochondria swelling, liposome hyperplasia. When the infrasound was up to 8 Hz/130 dB, the damage showed seriously. In 7 and 14 day group, the acute alteration was gradually decreased. A plenty of abnormal sperm were found. And other alteration was chromatin condense. The effect of variational frequency was important in ultrastructure. The infrasound markedly effected to testicular cell morphology and secreting function. Infrasound will lead to the alteration of procreation in mouse.

Response Surface Analysis of Stochastic Network Performance

DTIC Science & Technology

1988-12-01

Bl5/32768/, B16 /65536/,P/2147483647/ XHI-IX/B 16 XALO=(IX-XHI* Bl6 )*A LEFTLO=XALO/ Bl6 FHI=XHI*A+LEFTLO IC=FHI/B1 5 IX-(((XALO-LEFTLO* Bl6 )-P)4(FHI-K*Bl5...ELSE GO TO 50 END IF GO TO 50 100 END D-5 * RANDOM NUMBER GENERATOR FUNCTION RANDOM( IX) INTEGER AP, IX,B15, B16 ,XHI ,XALOI,LEFTLO,FHI ,K DATA A/16807... Bl6 )+K IF(IX.LT.O) IX=IX+P RANDOM-FLOAT( IX) *4.656612875E-1O RETURN END * NETWORK ENTRY and * PATHSET AND CUTSET GENERATION SUBROUTINE SUBROUTINE

Pregnant Canadian Women Achieve Recommended Intakes of One-Carbon Nutrients through Prenatal Supplementation but the Supplement Composition, Including Choline, Requires Reconsideration.

PubMed

Masih, Shannon P; Plumptre, Lesley; Ly, Anna; Berger, Howard; Lausman, Andrea Y; Croxford, Ruth; Kim, Young-In; O'Connor, Deborah L

2015-08-01

Folate, vitamin B-6, vitamin B-12, and choline are involved in one-carbon metabolism and play critical roles in pregnancy including prevention of birth defects and promotion of neurodevelopment. However, excessive intakes may adversely affect disease susceptibility in offspring. Intakes of these nutrients during pregnancy are not well characterized. Our aim was to determine dietary and supplemental intakes and major dietary sources of one-carbon nutrients during pregnancy. In pregnant women (n = 368) at ≤16 wk postconception, supplement use >30 d before pregnancy was assessed by maternal recall and supplement and dietary intakes in early (0-16 wk) and late pregnancy (23-37 wk) were assessed by food-frequency questionnaire. Preconception, 60.1% (95% CI: 55.8, 64.3) of women used B vitamin-containing supplements. This increased to 92.8% (95% CI: 89.6, 95.2) in early and 89.0% (95% CI: 85.0, 92.3) in late pregnancy. Median supplemental folic acid, vitamin B-12, and vitamin B-6 were 1000 μg/d, 2.6 μg/d, and 1.9 mg/d, respectively. Forty-one percent and 50% of women had dietary intakes of folate and vitamin B-6 less than the estimated average requirement (520 mg/d dietary folate equivalents and 1.6 mg/d, respectively). Eight-seven percent of women had choline intakes less than the Adequate Intake (450 mg/d). Dietary intakes did not change appreciably during pregnancy. Fruits and vegetables and fortified foods contributed ∼57% to total dietary folate intake. Fruits and vegetables contributed ∼32% to total dietary vitamin B-6 intake and dairy and egg products contributed ∼37% to total dietary vitamin B-12 intake. Vitamin supplements were an important source of one-carbon nutrients during pregnancy in our sample. Without supplements, many women would not have consumed quantities of folate and vitamin B-6 consistent with recommendations. Given the importance of choline in pregnancy, further research to consider inclusion in prenatal supplements is warranted. This trial was registered at clinicaltrials.gov as NCT02244684. © 2015 American Society for Nutrition.

Assessing the Accuracy of Density Functional and Semiempirical Wave Function Methods for Water Nanoparticles: Comparing Binding and Relative Energies of (H2O)16 and (H2O)17 to CCSD(T) Results.

PubMed

Leverentz, Hannah R; Qi, Helena W; Truhlar, Donald G

2013-02-12

The binding energies and relative conformational energies of five configurations of the water 16-mer are computed using 61 levels of density functional (DF) theory, 12 methods combining DF theory with molecular mechanics damped dispersion (DF-MM), seven semiempirical-wave function (SWF) methods, and five methods combining SWF theory with molecular mechanics damped dispersion (SWF-MM). The accuracies of the computed energies are assessed by comparing them to recent high-level ab initio results; this assessment is more relevant to bulk water than previous tests on small clusters because a 16-mer is large enough to have water molecules that participate in more than three hydrogen bonds. We find that for water 16-mer binding energies the best DF, DF-MM, SWF, and SWF-MM methods (and their mean unsigned errors in kcal/mol) are respectively M06-2X (1.6), ωB97X-D (2.3), SCC-DFTB-γ(h) (35.2), and PM3-D (3.2). We also mention the good performance of CAM-B3LYP (1.8), M05-2X (1.9), and TPSSLYP (3.0). In contrast, for relative energies of various water nanoparticle 16-mer structures, the best methods (and mean unsigned errors in kcal/mol), in the same order of classes of methods, are SOGGA11-X (0.3), ωB97X-D (0.2), PM6 (0.4), and PMOv1 (0.6). We also mention the good performance of LC-ωPBE-D3 (0.3) and ωB97X (0.4). When both relative and binding energies are taken into consideration, the best methods overall (out of the 85 tested) are M05-2X without molecular mechanics and ωB97X-D when molecular mechanics corrections are included; with considerably higher average errors and considerably lower cost, the best SWF or SWF-MM method is PMOv1. We use six of the best methods for binding energies of the water 16-mers to calculate the binding energies of water hexamers and water 17-mers to test whether these methods are also reliable for binding energy calculations on other types of water clusters.

The milk delivery chain and presence of Brucella spp. antibodies in bulk milk in Uganda.

PubMed

Rock, Kim Toeroek; Mugizi, Denis Rwabiita; Ståhl, Karl; Magnusson, Ulf; Boqvist, Sofia

2016-06-01

This study examined the influence of informal milk delivery chains on the risk of human exposure to Brucella spp. through milk consumption in two regions of Uganda (Gulu and Soroti Districts). The work involved describing milk delivery chains, investigating brucellosis awareness amongst milk deliverers and determining the presence of Brucella spp. antibodies in cattle milk on delivery to primary collection points (boiling points and dairies). Milk samples (n = 331) were collected from deliverers at primary collection points and from street vendors at point of sale and analysed using indirect enzyme-linked immunosorbent assay (I-ELISA). A written questionnaire was used to collect data from deliverers (n = 279) on their milk delivery chains and their brucellosis awareness. The most common delivery points in Gulu District were small dairies and in Soroti District boiling points. The presence of Brucella spp. antibodies in milk samples was higher in Soroti (40 %) than in Gulu (11 %) (P < 0.0001). There are possible public health risk consequences of this finding as 42 % of deliverers in Soroti District reported drinking raw milk, compared with 15 % in Gulu District (P < 0.0001). Awareness of brucellosis was low, with 70 % of all milk deliverers reporting not having heard of the disease or the bacterium. Application of quality controls for milk (colour and odour) along the delivery chain varied depending upon supply and demand. This study provides evidence of the diversity of informal milk markets in low-income countries and of the potential public health risks of consuming unpasteurised milk. These results can be useful to those planning interventions to reduce brucellosis.

Coding gains and error rates from the Big Viterbi Decoder

NASA Technical Reports Server (NTRS)

Onyszchuk, I. M.

1991-01-01

A prototype hardware Big Viterbi Decoder (BVD) was completed for an experiment with the Galileo Spacecraft. Searches for new convolutional codes, studies of Viterbi decoder hardware designs and architectures, mathematical formulations, and decompositions of the deBruijn graph into identical and hierarchical subgraphs, and very large scale integration (VLSI) chip design are just a few examples of tasks completed for this project. The BVD bit error rates (BER), measured from hardware and software simulations, are plotted as a function of bit signal to noise ratio E sub b/N sub 0 on the additive white Gaussian noise channel. Using the constraint length 15, rate 1/4, experimental convolutional code for the Galileo mission, the BVD gains 1.5 dB over the NASA standard (7,1/2) Maximum Likelihood Convolution Decoder (MCD) at a BER of 0.005. At this BER, the same gain results when the (255,233) NASA standard Reed-Solomon decoder is used, which yields a word error rate of 2.1 x 10(exp -8) and a BER of 1.4 x 10(exp -9). The (15, 1/6) code to be used by the Cometary Rendezvous Asteroid Flyby (CRAF)/Cassini Missions yields 1.7 dB of coding gain. These gains are measured with respect to symbols input to the BVD and increase with decreasing BER. Also, 8-bit input symbol quantization makes the BVD resistant to demodulated signal-level variations which may cause higher bandwidth than the NASA (7,1/2) code, these gains are offset by about 0.1 dB of expected additional receiver losses. Coding gains of several decibels are possible by compressing all spacecraft data.

Abnormally banded chromosomal regions in doxorubicin-resistant B16-BL6 murine melanoma cells.

PubMed

Slovak, M L; Hoeltge, G A; Ganapathi, R

1986-08-01

B16-BL6 murine melanoma cells were selected for cytogenetic evaluation during the stepwise development of increasing resistance in vitro to the antitumor antibiotic, doxorubicin (DOX). Karyotypic studies demonstrated extensive heteroploidy with both numerical and structural abnormalities which were not present in the parental DOX-sensitive B16-BL6 cells. Trypsin-Giemsa banding revealed the presence of several marker chromosomes containing abnormally banding regions (ABRs) in the 44-fold B16-BL6 DOX-resistant subline. These ABRs appeared to be more homogeneously staining at the higher DOX concentrations. Length measurements (ABR index) in seven banded metaphases indicated a direct correlation with increasing DOX concentration. When the DOX-resistant cells were grown in drug-free medium for 1 yr, the drug-resistant phenotype gradually declined in parallel with the level of resistance and the ABR index. DOX-induced cytogenetic damage examined by sister chromatid exchange methodology in parental B16-BL6 cells indicated a linear sister chromatid exchange:DOX dose-response relationship. However, after continuous treatment of parental B16-BL6 cells with DOX (0.01 microgram/ml) for 30 days, sister chromatid exchange scores were found to return to base-line values. The B16-BL6 resistant cells demonstrated a cross-resistant phenotype with N-trifluoroacetyladriamycin-14-valerate, actinomycin D, and the Vinca alkaloids but not with 1-beta-D-arabinofuranosylcytosine. The results suggest that ABR-containing chromosomes in DOX-resistant sublines may represent cytogenetic alterations of specific amplified genes involved in the expression of DOX resistance. Further studies are required to identify and define the possible gene products and to correlate their relationship to the cytotoxic action of doxorubicin.

Phylogeography of Coxsackievirus A16 Reveals Global Transmission Pathways and Recent Emergence and Spread of a Recombinant Genogroup.

PubMed

Hassel, Chervin; Mirand, Audrey; Farkas, Agnes; Diedrich, Sabine; Huemer, Hartwig P; Peigue-Lafeuille, Hélène; Archimbaud, Christine; Henquell, Cécile; Bailly, Jean-Luc

2017-09-15

Coxsackievirus A16 (CV-A16; Picornaviridae ) is an enterovirus (EV) type associated with hand, foot, and mouth disease (HFMD) in children. To investigate the spatial spread of CV-A16, we used viral sequence data sampled during a prospective sentinel surveillance of HFMD in France (2010 to 2014) and phylogenetic reconstruction. A data set of 168 VP1 sequences was assembled with 416 publicly available sequences of various geographic origins. The CV-A16 sequences reported were assigned to two clades, genogroup B and a previously uncharacterized clade D. The time origins of clades B and D were assessed in 1978 (1973 to 1981) and 2004 (2001 to 2007), respectively. The shape of the global CV-A16 phylogeny indicated worldwide cocirculation of genetically distinct virus lineages over time and across geographic regions. Phylogenetic tree topologies and Bayes factor analysis indicated virus migration. Virus transportation events in clade B within Europe and Asia and between countries of the two geographic regions were assessed. The sustained transmission of clade D viruses over 4 years was analyzed at the township level in France and traced back to Peru in South America. Comparative genomics provided evidence of recombination between CV-A16 clades B and D and suggested an intertype recombinant origin for clade D. Time-resolved phylogenies and HFMD surveillance data indicated that CV-A16 persistence is sustained by continuing virus migration at different geographic scales, from community transmission to virus transportation between distant countries. The results showed a significant impact of virus movements on the epidemiological dynamics of HFMD that could have implications for disease prevention. IMPORTANCE Coxsackievirus A16 is one of the most prevalent enterovirus types in hand, foot, and mouth disease outbreaks reported in Southeast Asia. This study is based on epidemiological and viral data on HFMD caused by CV-A16 in a European country. The phylogeographic data complemented the syndromic surveillance with virus migration patterns between geographic regions in France. The results show how viral evolutionary dynamics and global virus spread interact to shape the worldwide pattern of an EV disease. CV-A16 transmission is driven by movements of infected individuals at different geographic levels: within a country (local dynamics), between neighboring countries (regional dynamics), and between distant countries (transcontinental dynamics). The results are consistent with our earlier data on EV-A71 and confirm the epidemiological interconnection of Asia and Europe with regard to EV infections. Copyright © 2017 American Society for Microbiology.

The amount of decrease of the background white noise intensity as a cue for differentiation training.

PubMed

Zieliński, K

1981-01-01

The course of differentiation learning, using the conditioned emotional response (CER) method, was investigated in two groups of 16 rats. The discriminative stimuli consisted of decreases in the 80 dB background white noise to either 70 dB or 60 dB. Differentiation learning was more efficient with the larger decrease of background noise intensity as the CS(+) and the smaller decrease as the CS(-) than vice versa.

Confronting Space Debris: Strategies and Warnings from Comparable Examples Including Deepwater Horizon

DTIC Science & Technology

2010-01-01

Horizon (DH) was an ultra deepwater , semisubmers- ible offshore drilling rig contracted to BP by its owner, Transocean. The rig was capable of...Warnings from Comparable Examples Including Deepwater Horizon 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d. PROJECT...research quality and objectivity. StrategieS and WarningS from Comparable exampleS inCluding deepWater Horizon Confronting SpaCe DebriS dave baiocchi

Design and Experimental Implementation of Optimal Spacecraft Antenna Slews

DTIC Science & Technology

2013-12-01

LINK PENDULUM MODEL ............................................................58  C.  AZIMUTH-ELEVATION SYSTEM...BOUNDARY VALUE PROBLEM ......................77  B.  DOUBLE PENDULUM EXAMPLE............................................................82  C.  SOLVING THE...Figure 15.  Two-link Pendulum .........................................................................................58  Figure 16.  Double

A Systems Analysis and Design Case Study for a Business Modeling Learning Experience for a Capstone CIS/IS Systems Development Class

ERIC Educational Resources Information Center

Russell, Jack; Russell, Barbara

2015-01-01

The goal is to provide a robust and challenging problem statement for a capstone, advanced systems analysis and design course for CIS/MIS/CS majors. In addition to the problem narrative, a representative solution for much of the business modeling deliverables is presented using the UML paradigm. A structured analysis deliverable will be the topic…

The Additive Impact of Group and Individual Publicly Displayed Feedback: Examining Individual Response Patterns and Response Generalization in a Safe-Driving Occupational Intervention

ERIC Educational Resources Information Center

Ludwig, Timothy D.; Geller, E. Scott; Clarke, Steven W.

2010-01-01

Additive effects of publicly posting individual feedback following group goal-setting and feedback were evaluated. The turn-signal use of pizza deliverers was studied in a multiple baseline design across two pizza stores. After baseline observations, pizza deliverers voted on a group turn-signal goal and then received 4 weeks of group feedback on…

A Rendering System Independent High Level Architecture Implementation for Networked Virtual Environments

DTIC Science & Technology

2002-09-01

Management .........................15 5. Time Management ..............................16 6. Data Distribution Management .................16 D...50 b. Ownership Management .....................51 c. Data Distribution Management .............51 2. Additional Objects and Interactions...16 Figure 6. Data Distribution Management . (From: ref. 2) ...16 Figure 7. RTI and Federate Code Responsibilities. (From: ref. 2

A 2385 MHz, 2-stage low noise amplifier design

NASA Technical Reports Server (NTRS)

Sifri, Jack D.

1986-01-01

This article shows the design aspects of a 2.385 GHz low noise preamplifier with a .7 dB noise figure and 16.5 dB gain using the NE 67383 FET. The design uses a unique method in matching the input which achieves optimum noise figure and unconditional stability.

75 FR 69468 - Dentek.com, D/B/A Nsequence Center for Advanced Dentistry; Reno, NV; Notice of Affirmative...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-12

... DEPARTMENT OF LABOR Employment and Training Administration [TA-W-73,963] Dentek.com , D/B/A Nsequence Center for Advanced Dentistry; Reno, NV; Notice of Affirmative Determination Regarding Application for Reconsideration By application dated July 16, 2010, a petitioner requested administrative...

Improved measurement of B(D+ --> mu+nu) and the pseudoscalar decay constant fD+.

PubMed

Artuso, M; Boulahouache, C; Blusk, S; Butt, J; Dorjkhaidav, O; Li, J; Menaa, N; Mountain, R; Nandakumar, R; Randrianarivony, K; Redjimi, R; Sia, R; Skwarnicki, T; Stone, S; Wang, J C; Zhang, K; Csorna, S E; Bonvicini, G; Cinabro, D; Dubrovin, M; Lincoln, A; Briere, R A; Chen, G P; Chen, J; Ferguson, T; Tatishvili, G; Vogel, H; Watkins, M E; Rosner, J L; Adam, N E; Alexander, J P; Berkelman, K; Cassel, D G; Crede, V; Duboscq, J E; Ecklund, K M; Ehrlich, R; Fields, L; Gibbons, L; Gittelman, B; Gray, R; Gray, S W; Hartill, D L; Heltsley, B K; Hertz, D; Jones, C D; Kandaswamy, J; Kreinick, D L; Kuznetsov, V E; Mahlke-Krüger, H; Meyer, T O; Onyisi, P U E; Patterson, J R; Peterson, D; Phillips, E A; Pivarski, J; Riley, D; Ryd, A; Sadoff, A J; Schwarthoff, H; Shi, X; Shepherd, M R; Stroiney, S; Sun, W M; Urner, D; Wilksen, T; Weaver, K M; Weinberger, M; Athar, S B; Avery, P; Breva-Newell, L; Patel, R; Potlia, V; Stoeck, H; Yelton, J; Rubin, P; Cawlfield, C; Eisenstein, B I; Gollin, G D; Karliner, I; Kim, D; Lowrey, N; Naik, P; Sedlack, C; Selen, M; White, E J; Williams, J; Wiss, J; Asner, D M; Edwards, K W; Besson, D; Pedlar, T K; Cronin-Hennessy, D; Gao, K Y; Gong, D T; Hietala, J; Kubota, Y; Klein, T; Lang, B W; Li, S Z; Poling, R; Scott, A W; Smith, A; Dobbs, S; Metreveli, Z; Seth, K K; Tomaradze, A; Zweber, P; Ernst, J; Severini, H; Dytman, S A; Love, W; Mehrabyan, S; Mueller, J A; Savinov, V; Li, Z; Lopez, A; Mendez, H; Ramirez, J; Huang, G S; Miller, D H; Pavlunin, V; Sanghi, B; Shipsey, I P J; Adams, G S; Anderson, M; Cummings, J P; Danko, I; Napolitano, J; He, Q; Muramatsu, H; Park, C S; Thorndike, E H; Coan, T E; Gao, Y S; Liu, F

2005-12-16

We extract a relatively precise value for the decay constant of the meson by measuring B(D+ --> mu+nu) = (4.40 +/-0.66(+0.09)(-0.12) x 10(-4) using 281 pb(-1) of data taken on phi(3770) the resonance with the CLEO-c detector. We find fD+ = (222.6 +/- 16.7(+2.8)(-3.4)) MeV, and compare with current theoretical calculations. We also set a 90% confidence upper limit on B(D+e+nu)< 2.4 x 10(-5) which constrains new physics models.

Evidence for Bs* Bs* production at the Gamma(5S) resonance.

PubMed

Artuso, M; Boulahouache, C; Blusk, S; Butt, J; Dorjkhaidav, O; Li, J; Menaa, N; Mountain, R; Nandakumar, R; Randrianarivony, K; Redjimi, R; Sia, R; Skwarnicki, T; Stone, S; Wang, J C; Zhang, K; Csorna, S E; Bonvicini, G; Cinabro, D; Dubrovin, M; Bornheim, A; Pappas, S P; Weinstein, A J; Briere, R A; Chen, G P; Chen, J; Ferguson, T; Tatishvili, G; Vogel, H; Watkins, M E; Rosner, J L; Adam, N E; Alexander, J P; Berkelman, K; Cassel, D G; Crede, V; Duboscq, J E; Ecklund, K M; Ehrlich, R; Fields, L; Galik, R S; Gibbons, L; Gittelman, B; Gray, R; Gray, S W; Hartill, D L; Heltsley, B K; Hertz, D; Jones, C D; Kandaswamy, J; Kreinick, D L; Kuznetsov, V E; Mahlke-Krüger, H; Meyer, T O; Onyisi, P U E; Patterson, J R; Peterson, D; Phillips, E A; Pivarski, J; Riley, D; Ryd, A; Sadoff, A J; Schwarthoff, H; Shi, X; Shepherd, M R; Stroiney, S; Sun, W M; Urner, D; Wilksen, T; Weaver, K M; Weinberger, M; Athar, S B; Avery, P; Breva-Newell, L; Patel, R; Potlia, V; Stoeck, H; Yelton, J; Rubin, P; Cawlfield, C; Eisenstein, B I; Gollin, G D; Karliner, I; Kim, D; Lowrey, N; Naik, P; Sedlack, C; Selen, M; White, E J; Williams, J; Wiss, J; Asner, D M; Edwards, K W; Besson, D; Pedlar, T K; Cronin-Hennessy, D; Gao, K Y; Gong, D T; Hietala, J; Kubota, Y; Klein, T; Lang, B W; Li, S Z; Poling, R; Scott, A W; Smith, A; Dobbs, S; Metreveli, Z; Seth, K K; Tomaradze, A; Zweber, P; Ernst, J; Arms, K; Severini, H; Dytman, S A; Love, W; Mehrabyan, S; Mueller, J A; Savinov, V; Li, Z; Lopez, A; Mendez, H; Ramirez, J; Huang, G S; Miller, D H; Pavlunin, V; Sanghi, B; Shipsey, I P J; Adams, G S; Cravey, M; Cummings, J P; Danko, I; Napolitano, J; He, Q; Muramatsu, H; Park, C S; Thorndike, E H; Coan, T E; Gao, Y S; Liu, F; Stroynowski, R

2005-12-31

We use data collected by the CLEO III detector at the Cornell Electron Storage Ring to measure the inclusive yields of D(s) mesons as B(Y(5S) --> D(s)X) = (44-7 +/- 4.2 +/- 9.9)% and B(Y(4S) --> D(s)X) = (18.1 +/- 0.5 +/- 2.8)%. From these measurements, we make a model dependent estimate of the ratio of B(s)*B(s)* to the total bb quark pair production of (16.0 +/- 2.6 +/- 5.8)% at the Y(5S) energy.

Evaluation and Computational Characterization of the Faciliated Transport of Glc Carbon C-1 Oxime Reactivators Across a Blood Brain Barrier Model

DTIC Science & Technology

2013-01-01

parame- ters of these SOxs and the analysis of an additional novel SOx N-[(3- b-D-glucopyranosyloxy) propyl ]-2-pyridiniumaldoxime chloride (8c...penetration across the BBB. Expanding on thework of Heldman et al. [16] we compared their best SOx (N-[(3-b-D-glucopyranosyloxy) propyl ]-4-pyr...idiniumaldoxime chloride (8b)) and a novel SOx of our own design [9] (Fig. 1). Our SOx, N-[(3-b-D-glucopyranosyloxy)octyl]-2-pyr- idiniumaldoxime iodide (13c

Abstracts, 21st Annual Meeting Society of Engineering Science, Inc., October 15, 16 and 17, 1984.

DTIC Science & Technology

1984-01-01

ANALYSIS OF ADHESIVE JOINTS IN FIBER REINFORCED COMPOSITES by C. Burger*, D. Mallik **, A. Voloshin* and S. Mahadevan* *Department of Engineering Science...N. 33 (15A,44)Halkus, D.S. 301 ( 16 PM6) Olaosebikan, L. 89,95 (15PM2) Mallik , D. 356 (17AH2) Olhoff, N. 456,459 (l7PM4)Malone, J.B. 128 (15PM5

Triterpenoid saponins from Polaskia chichipe Backbg. and their inhibitory or promotional effects on the melanogenesis of B16 melanoma cells.

PubMed

Fujihara, Koji; Takahashi, Kunio; Koyama, Kiyotaka; Kinoshita, Kaoru

2017-10-01

Five new oleanane-type saponins 1-5 together with a known saponin 6 and a steroidal glycoside 7 were isolated from Polaskia chichipe Backbg., and their structures were determined from their 1D and 2D NMR and HRFABMS spectral data. The six isolated saponins 1-6 were tested for their effects on the melanogenesis of B16 melanoma 4A5 cells. Compound 1 exerted an inhibitory effect at 100 μM whereas compound 3 promoted melanogenesis at the same concentration, even though these two compounds contain the same aglycon structure. The dose-dependent activities of compounds 1 and 3 on melanin synthesis were investigated.

Hepatocellular carcinoma: short-term reproducibility of apparent diffusion coefficient and intravoxel incoherent motion parameters at 3.0T.

PubMed

Kakite, Suguru; Dyvorne, Hadrien; Besa, Cecilia; Cooper, Nancy; Facciuto, Marcelo; Donnerhack, Claudia; Taouli, Bachir

2015-01-01

To evaluate short-term test-retest and interobserver reproducibility of IVIM (intravoxel incoherent motion) diffusion parameters and ADC (apparent diffusion coefficient) of hepatocellular carcinoma (HCC) and liver parenchyma at 3.0T. In this prospective Institutional Review Board (IRB)-approved study, 11 patients were scanned twice using a free-breathing single-shot echo-planar-imaging, diffusion-weighted imaging (DWI) sequence using 4 b values (b = 0, 50, 500, 1000 s/mm(2)) and IVIM DWI using 16 b values (0-800 s/mm(2)) at 3.0T. IVIM parameters (D: true diffusion coefficient, D*: pseudodiffusion coefficient, PF: perfusion fraction) and ADC (using 4 b and 16 b) were calculated. Short-term test-retest and interobserver reproducibility of IVIM parameters and ADC were assessed by measuring correlation coefficient, coefficient of variation (CV), and Bland-Altman limits of agreements (BA-LA). Fifteen HCCs were assessed in 10 patients. Reproducibility of IVIM metrics in HCC was poor for D* and PF (mean CV 60.6% and 37.3%, BA-LA: -161.6% to 135.3% and -66.2% to 101.0%, for D* and PF, respectively), good for D and ADC (CV 19.7% and <16%, BA-LA -57.4% to 36.3% and -38.2 to 34.1%, for D and ADC, respectively). Interobserver reproducibility was on the same order of test-retest reproducibility except for PF in HCC. Reproducibility of diffusion parameters was better in liver parenchyma compared to HCC. Poor reproducibility of D*/PF and good reproducibility for D/ADC were observed in HCC and liver parenchyma. These findings may have implications for trials using DWI in HCC. © 2014 Wiley Periodicals, Inc.

48 CFR 22.1006 - Solicitation provisions and contract clauses.

Code of Federal Regulations, 2014 CFR

2014-10-01

... Certain Equipment—Certification; (B) 52.222-52, Exemption from Application of the Service Contract Labor...)(4)(ii) of this subsection). (b) The contracting officer shall insert the clause at 52.222-42... (subparagraphs (d) (1), (2) and (3)), or 52.222-44 (subparagraphs (b) (1) and (2)). (For example, the prior year...

Bacterial sulfite dehydrogenases in organotrophic metabolism: separation and identification in Cupriavidus necator H16 and in Delftia acidovorans SPH-1.

PubMed

Denger, Karin; Weinitschke, Sonja; Smits, Theo H M; Schleheck, David; Cook, Alasdair M

2008-01-01

The utilization of organosulfonates as carbon sources by aerobic or nitrate-reducing bacteria usually involves a measurable, uncharacterized sulfite dehydrogenase. This is tacitly assumed to be sulfite : ferricytochrome-c oxidoreductase [EC 1.8.2.1], despite negligible interaction with (eukaryotic) cytochrome c: the enzyme is assayed at high specific activity with ferricyanide as electron acceptor. Purified periplasmic sulfite dehydrogenases (SorAB, SoxCD) are known from chemoautotrophic growth and are termed 'sulfite oxidases' by bioinformatic services. The catalytic unit (SorA, SoxC; termed 'sulfite oxidases' cd02114 and cd02113, respectively) binds a molybdenum-cofactor (Moco), and involves a cytochrome c (SorB, SoxD) as electron acceptor. The genomes of several bacteria that express a sulfite dehydrogenase during heterotrophic growth contain neither sorAB nor soxCD genes; others contain at least four paralogues, for example Cupriavidus necator H16, which is known to express an inducible sulfite dehydrogenase during growth with taurine (2-aminoethanesulfonate). This soluble enzyme was enriched 320-fold in four steps. The 40 kDa protein (denatured) had an N-terminal amino acid sequence which started at position 42 of the deduced sequence of H16_B0860 (termed 'sulfite oxidase' cd02114), which we named SorA. The neighbouring gene is an orthologue of sorB, and the sorAB genes were co-transcribed. Cell fractionation showed SorA to be periplasmic. The corresponding enzyme in Delftia acidovorans SPH-1 was enriched 270-fold, identified as Daci_0055 (termed 'sulfite oxidase' cd02110) and has a cytochrome c encoded downstream. We presume, from genomic data for bacteria and archaea, that there are several subgroups of sulfite dehydrogenases, which all contain a Moco, and transfer electrons to a specific cytochrome c.

Characterization of monoclonal antibodies that specifically recognize the palm subdomain of hepatitis C virus nonstructural protein 5B polymerase.

PubMed

Ingravallo, P; Lahser, F; Xia, E; Sodowich, B; Lai, V C; Hong, Z; Zhong, W

2001-06-01

The nonstructural protein 5B (NS5B) of hepatitis C virus (HCV) is an RNA-dependent RNA polymerase (RdRp) which plays an essential role in viral RNA replication. Antibodies that specifically recognize NS5B will have utilities in monitoring NS5B production and subcellular localization, as well as in structure-function studies. In this report, three mouse monoclonal antibodies (mAbs), 16A9C9, 16D9A4 and 20A12C7, against a recombinant NS5B protein (genotype 1a, H-77 strain) were produced. These mAbs specifically recognize HCV NS5B, but not RdRps of polivirus (PV), bovine viral diarrhea virus (BVDV) or GB virus B (GBV-B). The mAbs can readily detect NS5B in cellular lysates of human osteosarcoma Saos2 cells constitutively expressing the nonstructural region of HCV (NS3-NS4A-NS4B-NS5A-NS5B). NS5B proteins of different HCV genotypes/subtypes (1a, 1b, 2a, 2c, 5a) showed varied affinity for these mAbs. Interestingly, the epitopes for the mAbs were mapped to the palm subdomain (amino acid 188-370) of the HCV RdRp as determined by immunoblotting analysis of a panel of HCV/GBV-B chimeric NS5B proteins. The binding site was mapped between amino acid 231 and 267 of NS5B for 16A9C9, and between 282 and 372 for 16D9A4 and 20A12C7. Furthermore, these mAbs showed no inhibitory effect on the NS5B polymerase activity in vitro.

Cytotoxicity of the coagulant Moringa oleifera lectin (cMoL) to B16-F10 melanoma cells.

PubMed

de Andrade Luz, Luciana; Rossato, Franco Aparecido; Costa, Rute Alves Pereira E; Napoleão, Thiago Henrique; Paiva, Patrícia Maria Guedes; Coelho, Luana Cassandra Breitenbach Barroso

2017-10-01

Moringa oleifera seeds are used in alternative medicine to treat inflammation, tumors and bacterial and protozoan infections, for example. The seeds contain lectins, which are carbohydrate-binding proteins with several biological properties including cytotoxicity to cancer cells. In this work, we examined the cytotoxicity of the coagulant M. oleifera lectin (cMoL) on B16-F10 murine melanoma cells. cMoL cytotoxic effects were evaluated through trypan blue assay and flow cytometry analysis. Mitochondrial superoxide levels and activation of caspases 3, 8 and 9 were measured. cMoL (1.5-16μM) reduced viability and caused cell death of B16-F10 cells with an IC 50 of 9.72μM. Flow cytometry analysis indicated induction of necrosis and suggested the presence of cells in late apoptosis. Specificity for tumor cells was observed since death of normal human fibroblasts (GN) was not higher than 20% in treatments with cMoL from 1.5 to 16μM. Microscopy images revealed rounded shape and reduction of volume in B16-F10 cells treated with cMoL. cMoL increased mitochondrial ROS production and promoted caspases 3, 8 and 9 activation in B16-F10 cells, indicating the activation of apoptosis-related pathway. In conclusion, this study demonstrates that cMoL is cytotoxic to B16-F10 cells, which stimulates more investigation on the anticancer potential of this lectin. Copyright © 2017 Elsevier Ltd. All rights reserved.

14 CFR 217.10 - Instructions.

Code of Federal Regulations, 2013 CFR

2013-01-01

... and the other pertaining to on-flight markets. For example, the routing (A-B-C-D) consists of three..., Singapore A-3—Airport code Origin A-4—Airport code Destination A-5—Service class (mark an X) F G L P Q By aircraft type— B-1—Aircraft type code B-2—Revenue aircraft departures B-3—Revenue passengers transported B...

14 CFR 217.10 - Instructions.

Code of Federal Regulations, 2012 CFR

2012-01-01

... and the other pertaining to on-flight markets. For example, the routing (A-B-C-D) consists of three..., Singapore A-3—Airport code Origin A-4—Airport code Destination A-5—Service class (mark an X) F G L P Q By aircraft type— B-1—Aircraft type code B-2—Revenue aircraft departures B-3—Revenue passengers transported B...

14 CFR 217.10 - Instructions.

Code of Federal Regulations, 2014 CFR

2014-01-01

... and the other pertaining to on-flight markets. For example, the routing (A-B-C-D) consists of three..., Singapore A-3—Airport code Origin A-4—Airport code Destination A-5—Service class (mark an X) F G L P Q By aircraft type— B-1—Aircraft type code B-2—Revenue aircraft departures B-3—Revenue passengers transported B...

Bayesian, maximum parsimony and UPGMA models for inferring the phylogenies of antelopes using mitochondrial markers.

PubMed

Khan, Haseeb A; Arif, Ibrahim A; Bahkali, Ali H; Al Farhan, Ahmad H; Al Homaidan, Ali A

2008-10-06

This investigation was aimed to compare the inference of antelope phylogenies resulting from the 16S rRNA, cytochrome-b (cyt-b) and d-loop segments of mitochondrial DNA using three different computational models including Bayesian (BA), maximum parsimony (MP) and unweighted pair group method with arithmetic mean (UPGMA). The respective nucleotide sequences of three Oryx species (Oryx leucoryx, Oryx dammah and Oryx gazella) and an out-group (Addax nasomaculatus) were aligned and subjected to BA, MP and UPGMA models for comparing the topologies of respective phylogenetic trees. The 16S rRNA region possessed the highest frequency of conserved sequences (97.65%) followed by cyt-b (94.22%) and d-loop (87.29%). There were few transitions (2.35%) and none transversions in 16S rRNA as compared to cyt-b (5.61% transitions and 0.17% transversions) and d-loop (11.57% transitions and 1.14% transversions) while comparing the four taxa. All the three mitochondrial segments clearly differentiated the genus Addax from Oryx using the BA or UPGMA models. The topologies of all the gamma-corrected Bayesian trees were identical irrespective of the marker type. The UPGMA trees resulting from 16S rRNA and d-loop sequences were also identical (Oryx dammah grouped with Oryx leucoryx) to Bayesian trees except that the UPGMA tree based on cyt-b showed a slightly different phylogeny (Oryx dammah grouped with Oryx gazella) with a low bootstrap support. However, the MP model failed to differentiate the genus Addax from Oryx. These findings demonstrate the efficiency and robustness of BA and UPGMA methods for phylogenetic analysis of antelopes using mitochondrial markers.

Bayesian, Maximum Parsimony and UPGMA Models for Inferring the Phylogenies of Antelopes Using Mitochondrial Markers

PubMed Central

Khan, Haseeb A.; Arif, Ibrahim A.; Bahkali, Ali H.; Al Farhan, Ahmad H.; Al Homaidan, Ali A.

2008-01-01

This investigation was aimed to compare the inference of antelope phylogenies resulting from the 16S rRNA, cytochrome-b (cyt-b) and d-loop segments of mitochondrial DNA using three different computational models including Bayesian (BA), maximum parsimony (MP) and unweighted pair group method with arithmetic mean (UPGMA). The respective nucleotide sequences of three Oryx species (Oryx leucoryx, Oryx dammah and Oryx gazella) and an out-group (Addax nasomaculatus) were aligned and subjected to BA, MP and UPGMA models for comparing the topologies of respective phylogenetic trees. The 16S rRNA region possessed the highest frequency of conserved sequences (97.65%) followed by cyt-b (94.22%) and d-loop (87.29%). There were few transitions (2.35%) and none transversions in 16S rRNA as compared to cyt-b (5.61% transitions and 0.17% transversions) and d-loop (11.57% transitions and 1.14% transversions) while comparing the four taxa. All the three mitochondrial segments clearly differentiated the genus Addax from Oryx using the BA or UPGMA models. The topologies of all the gamma-corrected Bayesian trees were identical irrespective of the marker type. The UPGMA trees resulting from 16S rRNA and d-loop sequences were also identical (Oryx dammah grouped with Oryx leucoryx) to Bayesian trees except that the UPGMA tree based on cyt-b showed a slightly different phylogeny (Oryx dammah grouped with Oryx gazella) with a low bootstrap support. However, the MP model failed to differentiate the genus Addax from Oryx. These findings demonstrate the efficiency and robustness of BA and UPGMA methods for phylogenetic analysis of antelopes using mitochondrial markers. PMID:19204824

Mode Competition in the Quasioptical Gyrotron

DTIC Science & Technology

1990-05-30

dvid Jd n J C nH ]d. v1 dCl v-1 J dC4 vm M Jd ;v M_ &(vl- v1 ) 6(vn - vn °) & r- vm ). (B18) It is clear from (B16)-( BI8 ) that r, G and D depend...AZ 85721 Attn: Dr. Willis E. Lamb, Jr. 1 copy Physical Sciences, Inc. 635 Slaters Lane #G101 Alexandria, VA 22314-1112 ATTN: Dr. M.E. Read 1 copy

Average optimal DPOAE primary tone levels in normal-hearing adults.

PubMed

Marcrum, Steven C; Kummer, Peter; Kreitmayer, Christoph; Steffens, Thomas

2016-01-01

Despite great progress towards optimizing DPOAE primary tone characteristics, factors such as stimulus and intra-subject emission variability have not been addressed. The purpose of this study was to identify optimal primary tone level relationships when these sources of variability were acknowledged, and to identify any influences of test frequency. Following coupler-based measurements assessing primary tone level stability, two experiments were conducted. In experiment 1, DPOAE test-retest reliability without probe replacement was measured for f2 = 1-6 kHz with L1 = L2 = 65 dB SPL. In experiment 2, optimal L1-L2 relationships were identified for f2 = 1-6 kHz. For 20 ≤ L2 ≤ 75 dB SPL, L1 was varied 15 dB SPL above and below the recommendation of L1 = 0.4 L2 + 39 [dB SPL]. Eleven normal-hearing adults participated in experiment 1. Thirty normal-hearing adults participated in experiment 2. Stimulus variability did not exceed 0.1 dB SPL. DPOAE reliability testing revealed an across-frequency mean standard error of measurement of 0.52 dB SPL. The average optimal L1-L2 relationship was described by L1 = 0.49 L2 + 41 [dB SPL]. A significant effect of frequency was identified for 6 kHz. Including relevant sources of variability improves internal validity of a primary tone level optimization formula.

Measurement of the branching ratio of B ¯ 0 → D * + τ - ν ¯ τ relative to B ¯ 0 → D * + ℓ - ν ¯ ℓ decays with a semileptonic tagging method

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sato, Y.; Iijima, T.; Adamczyk, K.

We report a measurement of the ratio R(D*)=B(more » $$\\bar{B}$$ 0→D* +τ -$$\\bar{v}$$$\\bar{τ}$$)/B($$\\bar{B}$$ 0→D* +ℓ -$$\\bar{v}$$ℓ), where ℓ denotes an electron or a muon. The results are based on a data sample containing 772×10 6 B$$\\bar{B}$$ pairs recorded at the Υ(4S) resonance with the Belle detector at the KEKB e +e - collider. We select a sample of B0$$\\bar{B}$$ 0 pairs by reconstructing both B mesons in semileptonic decays to D* ∓ℓ ±. We measure R(D*)=0.302±0.030(stat)±0.011(syst), which is within 1.6σ of the Standard Model theoretical expectation, where the standard deviation σ includes systematic uncertainties. We use this measurement to constrain several scenarios of new physics in a model-independent approach.« less

Noise exposure and auditory thresholds of German airline pilots: a cross-sectional study

PubMed Central

Müller, Reinhard; Schneider, Joachim

2017-01-01

Objective The cockpit workplace of airline pilots is a noisy environment. This study examines the hearing thresholds of pilots with respect to ambient noise and communication sound. Methods The hearing of 487 German pilots was analysed by audiometry in the frequency range of 125 Hz–16 kHz in varying age groups. Cockpit noise (free-field) data and communication sound (acoustic manikin) measurements were evaluated. Results The ambient noise levels in cockpits were found to be between 74 and 80 dB(A), and the sound pressure levels under the headset were found to be between 84 and 88 dB(A). The left–right threshold differences at 3, 4 and 6 kHz show evidence of impaired hearing at the left ear, which worsens by age. In the age groups <40/≥40 years the mean differences at 3 kHz are 2/3 dB, at 4 kHz 2/4 dB and at 6 kHz 1/6 dB. In the pilot group which used mostly the left ear for communication tasks (43 of 45 are in the older age group) the mean difference at 3 kHz is 6 dB, at 4 kHz 7 dB and at 6 kHz 10 dB. The pilots who used the headset only at the right ear also show worse hearing at the left ear of 2 dB at 3 kHz, 3 dB at 4 kHz and at 6 kHz. The frequency-corrected exposure levels under the headset are 7–11 dB(A) higher than the ambient noise with an averaged signal-to-noise ratio for communication of about 10 dB(A). Conclusions The left ear seems to be more susceptible to hearing loss than the right ear. Active noise reduction systems allow for a reduced sound level for the communication signal below the upper exposure action value of 85 dB(A) and allow for a more relaxed working environment for pilots. PMID:28559452

Contracted or uncontracted polarization functions? Comment on Dunning's correlation-consistent basis sets

NASA Astrophysics Data System (ADS)

Hashimoto, Tomohiro; Hirao, Kimihiko; Tatewaki, Hiroshi

1997-07-01

For the sake of computational economy, the polarization functions given by Dunning are contracted by multiconfigurational SCF calculations for H, B, C, N, O, F and Ne atoms. For the first-row atoms, B through Ne, the generated contracted polarization functions are ( 2 d/1 d) and ( 3 d/2 d) and for H they are ( 2 p/1 p), ( 3 p/1 p), and ( 3 p/2 p) where the numbers before and after the slash are the numbers of uncontracted and contracted polarization functions. Numerical examples on some diatomic molecules and benzene illustrate a large improvement in going from ( 1 d/1 dto ( 2 d/1 d) for various molecular properties.

The F-16 Onboard Oxygen Generating System: Performance Evaluation and Man Rating

DTIC Science & Technology

1983-08-01

OXYGEN GENERATING , YSTEM: PERFORMANCE EVALUATION AND MAN RATING Thomas C. Horch , Captain, USAF Richard L. Miller, Ph.D. John B. Bomar, Jr...C. Horch , Capt, USAF; R. L. Miller, 8. CONTRACT OR GRANT NUMBER(i) Ph.D.; J. B. Bomar, Jr., Lt Col, IJSAF, BSC; J. B. Tedor, Maj, USAF, BSC; R. D...limitation (as of 1983); however, the information may no longer need protection since it is 14 years. At the time of its publication, Capt Thomas Horch

Non-Linear Metamodeling Extensions to the Robust Parameter Design of Computer Simulations

DTIC Science & Technology

2016-09-15

design By principal component analysis," Total Quality Management, vol. 8, no. 6, pp. 409-416, 1997. [25] A. Salmasnia, R. B . Kazemzadeh and S. T . A...and D. T . Sturrock, Simulation with Arena (3rd ed.), New York, NY: McGraw-Hill, 2004. [85] A. M. Mathai and S. B . Provost, Quadratic Forms in Random...PhD Member ADEDEJI B . BADIRU, PhD Dean, Graduate School of Engineering and Management iv AFIT-ENS-DS-16-S-026 Abstract Robust

Application of Conductive Carbon Nanotube Fibers and Composites: Gas Sensor

DTIC Science & Technology

2013-05-01

Lee, D.-D. Sensors and Actuators B: Chemical 2005, 108, 298–304. 31. Parikh, K.; Cattanach, K.; Rao , R.; Suh, D.-S.; Wu, A.; Manohar, S. K...Adv Mater 2004, 16, 2049–2052. 53. Zribi, A.; Knobloch, A.; Rao , R. Appl Phys Lett 2005, 86, 203112. 54. Philip, B.; Abraham, J. K.; Chandrasekhar, A...Yujin, C. et al. Nanotechnology 2006, 17, 3012. 61. Krishna Kumar, M.; Leela Mohana Reddy, A.; Ramaprabhu, S. Sensors and Actuators B: Chemical

Nanojets: Electrification, Energetics, Dynamics, Stability and Breakup

DTIC Science & Technology

2006-12-31

OF: 17. LIMITATION OF 18 . NUMBER 19a. NAME OF RESPONSIBLE PERSON a. REPORT b. ABSTRACT c. THIS PAGE ABSTRACT OF Dr Uzi Landman PAGES SU 19b. TELEPHONE...F(Ei )dE,. = Fm,, (Ero, )F,,h (Er,,b)dEro, dEwbh. (8) 16 where F,.ot( Erot ), and Fvwb(Evib) are the normalized rotational and vibrational Maxwell...corresponding to the concentrated solution, while the jet 18 dimensions are associated with radii in the range between 2.3 and 3.29 nm, with the larger

Drug Targets in Infections With Ebola and Marburg Viruses

DTIC Science & Technology

2009-01-01

Kew, M. C.; Bothwell, T . H.; Sher, R .; Miller, G. B.; Schneider, 1; Koomhof, H. 1; Gomperts, E. D.; Isaacson, M.; Gear, J. H. Br. Med. J., 1975,4(5995...489-93. [12] Smith, D, H.; Johnson, B. K.; Isaacson, M.; Swanapoel, R .; Johnson. K. M.; Killey, M.; Bagshawe, A; Siongok, T .; Keruga, W. K. Lancet...August 2007. Wkly Epidemiol Rec, 2007, 82(43) 381-4. (16] Towner, 1 S.; Khristova, M. L.; Sealy, T K.; Vincent, M. J.; Erickson, B. R .; Bawiec, D. A

8 CFR 1212.16 - Applications for exercise of discretion relating to T nonimmigrant status.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 8 Aliens and Nationality 1 2012-01-01 2012-01-01 false Applications for exercise of discretion...; WAIVERS; ADMISSION OF CERTAIN INADMISSIBLE ALIENS; PAROLE § 1212.16 Applications for exercise of... exercise of discretion under section 212(d)(13) or (d)(3)(B) of the Act (waivers of inadmissibility) in...

8 CFR 1212.16 - Applications for exercise of discretion relating to T nonimmigrant status.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 8 Aliens and Nationality 1 2013-01-01 2013-01-01 false Applications for exercise of discretion...; WAIVERS; ADMISSION OF CERTAIN INADMISSIBLE ALIENS; PAROLE § 1212.16 Applications for exercise of... exercise of discretion under section 212(d)(13) or (d)(3)(B) of the Act (waivers of inadmissibility) in...

8 CFR 1212.16 - Applications for exercise of discretion relating to T nonimmigrant status.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 8 Aliens and Nationality 1 2014-01-01 2014-01-01 false Applications for exercise of discretion...; WAIVERS; ADMISSION OF CERTAIN INADMISSIBLE ALIENS; PAROLE § 1212.16 Applications for exercise of... exercise of discretion under section 212(d)(13) or (d)(3)(B) of the Act (waivers of inadmissibility) in...

8 CFR 1212.16 - Applications for exercise of discretion relating to T nonimmigrant status.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 8 Aliens and Nationality 1 2011-01-01 2011-01-01 false Applications for exercise of discretion...; WAIVERS; ADMISSION OF CERTAIN INADMISSIBLE ALIENS; PAROLE § 1212.16 Applications for exercise of... exercise of discretion under section 212(d)(13) or (d)(3)(B) of the Act (waivers of inadmissibility) in...

8 CFR 1212.16 - Applications for exercise of discretion relating to T nonimmigrant status.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 8 Aliens and Nationality 1 2010-01-01 2010-01-01 false Applications for exercise of discretion...; WAIVERS; ADMISSION OF CERTAIN INADMISSIBLE ALIENS; PAROLE § 1212.16 Applications for exercise of... exercise of discretion under section 212(d)(13) or (d)(3)(B) of the Act (waivers of inadmissibility) in...

21 CFR 184.1212 - Calcium pantothenate.

Code of Federal Regulations, 2012 CFR

2012-04-01

... ((C9H16NO5)2Ca, CAS Reg. No. of the D-isomer, 137-08-6) is a salt of pantothenic acid, one of the vitamins of the B complex. Only the D-isomer of pantothenic acid has vitamin activity, although both the D-isomer..._regulations/ibr_locations.html. (c) In accordance with § 184.1(b)(1), the ingredient is used in food with no...

21 CFR 184.1212 - Calcium pantothenate.

Code of Federal Regulations, 2013 CFR

2013-04-01

... ((C9H16NO5)2Ca, CAS Reg. No. of the D-isomer, 137-08-6) is a salt of pantothenic acid, one of the vitamins of the B complex. Only the D-isomer of pantothenic acid has vitamin activity, although both the D-isomer..._regulations/ibr_locations.html. (c) In accordance with § 184.1(b)(1), the ingredient is used in food with no...

Quantum Noise in Laser Diodes

NASA Technical Reports Server (NTRS)

Giacobino, E.; Marin, F.; Bramati, A.; Jost, V.; Poizat, J. Ph.; Roch, J.-F.; Grangier, P.; Zhang, T.-C.

1996-01-01

We have investigated the intensity noise of single mode laser diodes, either free-running or using different types of line narrowing techniques at room temperature. We have measured an intensity squeezing of 1.2 dB with grating-extended cavity lasers and 1.4 dB with injection locked lasers (respectively 1.6 dB and 2.3 dB inferred at the laser output). We have observed that the intensity noise of a free-running nominally single mode laser diode results from a cancellation effect between large anti-correlated fluctuations of the main mode and of weak longitudinal side modes. Reducing the side modes by line narrowing techniques results in intensity squeezing.

Potential for reduced toxicity and dose escalation in the treatment of inoperable non-small-cell lung cancer: a comparison of intensity-modulated radiation therapy (IMRT), 3D conformal radiation, and elective nodal irradiation.

PubMed

Grills, Inga S; Yan, Di; Martinez, Alvaro A; Vicini, Frank A; Wong, John W; Kestin, Larry L

2003-11-01

To systematically evaluate four different techniques of radiation therapy (RT) used to treat non-small-cell lung cancer and to determine their efficacy in meeting multiple normal-tissue constraints while maximizing tumor coverage and achieving dose escalation. Treatment planning was performed for 18 patients with Stage I to IIIB inoperable non-small-cell lung cancer using four different RT techniques to treat the primary lung tumor +/- the hilar/mediastinal lymph nodes: (1) Intensity-modulated radiation therapy (IMRT), (2) Optimized three-dimensional conformal RT (3D-CRT) using multiple beam angles, (3) Limited 3D-CRT using only 2 to 3 beams, and (4) Traditional RT using elective nodal irradiation (ENI) to treat the mediastinum. All patients underwent virtual simulation, including a CT scan and (18)fluorodeoxyglucose positron emission tomography scan, fused to the CT to create a composite tumor volume. For IMRT and 3D-CRT, the target included the primary tumor and regional nodes either > or =1.0 cm in short-axis dimension on CT or with increased uptake on PET. For ENI, the target included the primary tumor plus the ipsilateral hilum and mediastinum from the inferior head of the clavicle to at least 5.0 cm below the carina. The goal was to deliver 70 Gy to > or =99% of the planning target volume (PTV) in 35 daily fractions (46 Gy to electively treated mediastinum) while meeting multiple normal-tissue dose constraints. Heterogeneity correction was applied to all dose calculations (maximum allowable heterogeneity within PTV 30%). Pulmonary and esophageal constraints were as follows: lung V(20) < or =25%, mean lung dose < or =15 Gy, esophagus V(50) < or =25%, mean esophageal dose < or =25 Gy. At the completion of all planning, the four techniques were contrasted for their ability to achieve the set dose constraints and deliver tumoricidal RT doses. Requiring a minimum dose of 70 Gy within the PTV, we found that IMRT was associated with a greater degree of heterogeneity within the target and, correspondingly, higher mean doses and tumor control probabilities (TCPs), 7%-8% greater than 3D-CRT and 14%-16% greater than ENI. Comparing the treatment techniques in this manner, we found only minor differences between 3D-CRT and IMRT, but clearly greater risks of pulmonary and esophageal toxicity with ENI. The mean lung V(20) was 36% with ENI vs. 23%-25% with the three other techniques, whereas the average mean lung dose was approximately 21.5 Gy (ENI) vs. 15.5 Gy (others). Similarly, the mean esophagus V(50) was doubled with ENI, to 34% rather than 15%-18%. To account for differences in heterogeneity, we also compared the techniques giving each plan a tumor control probability equivalent to that of the optimized 3D-CRT plan delivering 70 Gy. Using this method, IMRT and 3D-CRT offered similar results in node-negative cases (mean lung and esophageal normal-tissue complication probability [NTCP] of approximately 10% and 2%-7%, respectively), but ENI was distinctly worse (mean NTCPs of 29% and 20%). In node-positive cases, however, IMRT reduced the lung V(20) and mean dose by approximately 15% and lung NTCP by 30%, compared to 3D-CRT. Compared to ENI, the reductions were 50% and >100%. Again, for node-positive cases, especially where the gross tumor volume was close to the esophagus, IMRT reduced the mean esophagus V(50) by 40% (vs. 3D-CRT) to 145% (vs. ENI). The esophageal NTCP was at least doubled converting from IMRT to 3D-CRT and tripled converting from IMRT to ENI. Finally, the total number of fractions for each plan was increased or decreased until all outlined normal-tissue constraints were reached/satisfied. While meeting all constraints, IMRT or 3D-CRT increased the deliverable dose in node-negative patients by >200% over ENI. In node-positive patients, IMRT increased the deliverable dose 25%-30% over 3D-CRT and 130%-140% over ENI. The use of 3D-CRT without IMRT increased the deliverable RT dose >80% over ENI. Using a limited number of 3D-CRT beams decreased the lung V(20), mean dose, and NTCP in node-positive patients. The use of 3D-CRT, particul mean dose, and NTCP in node-positive patients. The use of 3D-CRT, particularly with only 3 to 4 beam angles, has the ability to reduce normal-tissue toxicity, but has limited potential for dose escalation beyond the current standard in node-positive patients. IMRT is of limited additional value (compared to 3D-CRT) in node-negative cases, but is beneficial in node-positive cases and in cases with target volumes close to the esophagus. When meeting all normal-tissue constraints in node-positive patients, IMRT can deliver RT doses 25%-30% greater than 3D-CRT and 130%-140% greater than ENI. Whereas the possibility of dose escalation is severely limited with ENI, the potential for pulmonary and esophageal toxicity is clearly increased.

Measurement of the τ Lepton Polarization and R(D^{*}) in the Decay B[over ¯]→D^{*}τ^{-}ν[over ¯]_{τ}.

PubMed

Hirose, S; Iijima, T; Adachi, I; Adamczyk, K; Aihara, H; Al Said, S; Asner, D M; Atmacan, H; Aulchenko, V; Aushev, T; Ayad, R; Babu, V; Badhrees, I; Bakich, A M; Bansal, V; Barberio, E; Behera, P; Berger, M; Bhuyan, B; Biswal, J; Bondar, A; Bonvicini, G; Bozek, A; Bračko, M; Browder, T E; Červenkov, D; Chang, P; Chen, A; Cheon, B G; Chilikin, K; Chistov, R; Cho, K; Choi, Y; Cinabro, D; Danilov, M; Dash, N; Di Carlo, S; Dingfelder, J; Doležal, Z; Drásal, Z; Dutta, D; Eidelman, S; Epifanov, D; Farhat, H; Fast, J E; Ferber, T; Fulsom, B G; Gaur, V; Gabyshev, N; Garmash, A; Goldenzweig, P; Golob, B; Greenwald, D; Grygier, J; Haba, J; Hara, K; Hasenbusch, J; Hayasaka, K; Hayashii, H; Higuchi, T; Hou, W-S; Hsu, C-L; Inami, K; Inguglia, G; Ishikawa, A; Itoh, R; Iwasaki, Y; Jacobs, W W; Jaegle, I; Jin, Y; Joffe, D; Joo, K K; Julius, T; Kato, Y; Kawasaki, T; Kichimi, H; Kiesling, C; Kim, D Y; Kim, J B; Kim, K T; Kim, M J; Kim, S H; Kinoshita, K; Kodyš, P; Korpar, S; Kotchetkov, D; Križan, P; Krokovny, P; Kuhr, T; Kulasiri, R; Kumar, R; Kwon, Y-J; Lange, J S; Li, C H; Li, L; Li, Y; Li Gioi, L; Libby, J; Liventsev, D; Lubej, M; Luo, T; MacNaughton, J; Masuda, M; Matsuda, T; Matvienko, D; Miyabayashi, K; Miyake, H; Miyata, H; Mizuk, R; Mohanty, G B; Moon, H K; Mori, T; Mussa, R; Nakao, M; Nanut, T; Nath, K J; Natkaniec, Z; Nayak, M; Niiyama, M; Nisar, N K; Nishida, S; Ogawa, S; Okuno, S; Ono, H; Onuki, Y; Ostrowicz, W; Pakhlov, P; Pakhlova, G; Pal, B; Park, C W; Park, H; Paul, S; Pesántez, L; Pestotnik, R; Piilonen, L E; Prasanth, K; Ritter, M; Rostomyan, A; Rozanska, M; Sakai, Y; Sandilya, S; Santelj, L; Sanuki, T; Sato, Y; Savinov, V; Schlüter, T; Schneider, O; Schnell, G; Schwanda, C; Seino, Y; Senyo, K; Seon, O; Sevior, M E; Shebalin, V; Shen, C P; Shibata, T-A; Shiu, J-G; Simon, F; Sokolov, A; Solovieva, E; Starič, M; Strube, J F; Sumisawa, K; Sumiyoshi, T; Takizawa, M; Tamponi, U; Tenchini, F; Trabelsi, K; Uchida, M; Uglov, T; Unno, Y; Uno, S; Urquijo, P; Ushiroda, Y; Usov, Y; Van Hulse, C; Varner, G; Varvell, K E; Vossen, A; Wang, C H; Wang, M-Z; Wang, P; Watanabe, M; Watanabe, Y; Widmann, E; Won, E; Yamashita, Y; Ye, H; Yelton, J; Yuan, C Z; Zhang, Z P; Zhilich, V; Zhulanov, V; Zupanc, A

2017-05-26

We report the first measurement of the τ lepton polarization P_{τ}(D^{*}) in the decay B[over ¯]→D^{*}τ^{-}ν[over ¯]_{τ} as well as a new measurement of the ratio of the branching fractions R(D^{*})=B(B[over ¯]→D^{*}τ^{-}ν[over ¯]_{τ})/B(B[over ¯]→D^{*}ℓ^{-}ν[over ¯]_{ℓ}), where ℓ^{-} denotes an electron or a muon, and the τ is reconstructed in the modes τ^{-}→π^{-}ν_{τ} and τ^{-}→ρ^{-}ν_{τ}. We use the full data sample of 772×10^{6}  BB[over ¯] pairs recorded with the Belle detector at the KEKB electron-positron collider. Our results, P_{τ}(D^{*})=-0.38±0.51(stat)_{-0.16}^{+0.21}(syst) and R(D^{*})=0.270±0.035(stat)_{-0.025}^{+0.028}(syst), are consistent with the theoretical predictions of the standard model.

HHE/LORAN-C Surveying.

DTIC Science & Technology

1982-11-01

N* I. Khednipin.CeldegN. CG-D-Y4-82 4. Id ed I.ld j. D* NIUVin 1982U /LIAC WH ,. Peb- olm..,, Cede 9. Pwmln,, OWe, .omee . en Adoe., 10 . Wei Uat Me... 10 PRE-SURVEY PLANNING ..a-C ..hin.at.......................... 11 Overviewon of S ..... ........... 1......... ... .16 R eWaypoint Defintion...TDSS Statistics Summary.. ....................... 29 9 Example of Range-Range Waypoint Calculation.................30 10 Summary of Range-Range Waypoint

Simultaneous optimization of photons and electrons for mixed beam radiotherapy

NASA Astrophysics Data System (ADS)

Mueller, S.; Fix, M. K.; Joosten, A.; Henzen, D.; Frei, D.; Volken, W.; Kueng, R.; Aebersold, D. M.; Stampanoni, M. F. M.; Manser, P.

2017-07-01

The aim of this work is to develop and investigate an inverse treatment planning process (TPP) for mixed beam radiotherapy (MBRT) capable of performing simultaneous optimization of photon and electron apertures. A simulated annealing based direct aperture optimization (DAO) is implemented to perform simultaneous optimization of photon and electron apertures, both shaped with the photon multileaf collimator (pMLC). Validated beam models are used as input for Monte Carlo dose calculations. Consideration of photon pMLC transmission during DAO and a weight re-optimization of the apertures after deliverable dose calculation are utilized to efficiently reduce the differences between optimized and deliverable dose distributions. The TPP for MBRT is evaluated for an academic situation with a superficial and an enlarged PTV in the depth, a left chest wall case including the internal mammary chain and a squamous cell carcinoma case. Deliverable dose distributions of MBRT plans are compared to those of modulated electron radiotherapy (MERT), photon IMRT and if available to those of clinical VMAT plans. The generated MBRT plans dosimetrically outperform the MERT, photon IMRT and VMAT plans for all investigated situations. For the clinical cases of the left chest wall and the squamous cell carcinoma, the MBRT plans cover the PTV similarly or more homogeneously than the VMAT plans, while OARs are spared considerably better with average reductions of the mean dose to parallel OARs and D 2% to serial OARs by 54% and 26%, respectively. Moreover, the low dose bath expressed as V 10% to normal tissue is substantially reduced by up to 45% compared to the VMAT plans. A TPP for MBRT including simultaneous optimization is successfully implemented and the dosimetric superiority of MBRT plans over MERT, photon IMRT and VMAT plans is demonstrated for academic and clinical situations including superficial targets with and without deep-seated part.

Simultaneous optimization of photons and electrons for mixed beam radiotherapy.

PubMed

Mueller, S; Fix, M K; Joosten, A; Henzen, D; Frei, D; Volken, W; Kueng, R; Aebersold, D M; Stampanoni, M F M; Manser, P

2017-06-26

The aim of this work is to develop and investigate an inverse treatment planning process (TPP) for mixed beam radiotherapy (MBRT) capable of performing simultaneous optimization of photon and electron apertures. A simulated annealing based direct aperture optimization (DAO) is implemented to perform simultaneous optimization of photon and electron apertures, both shaped with the photon multileaf collimator (pMLC). Validated beam models are used as input for Monte Carlo dose calculations. Consideration of photon pMLC transmission during DAO and a weight re-optimization of the apertures after deliverable dose calculation are utilized to efficiently reduce the differences between optimized and deliverable dose distributions. The TPP for MBRT is evaluated for an academic situation with a superficial and an enlarged PTV in the depth, a left chest wall case including the internal mammary chain and a squamous cell carcinoma case. Deliverable dose distributions of MBRT plans are compared to those of modulated electron radiotherapy (MERT), photon IMRT and if available to those of clinical VMAT plans. The generated MBRT plans dosimetrically outperform the MERT, photon IMRT and VMAT plans for all investigated situations. For the clinical cases of the left chest wall and the squamous cell carcinoma, the MBRT plans cover the PTV similarly or more homogeneously than the VMAT plans, while OARs are spared considerably better with average reductions of the mean dose to parallel OARs and D 2% to serial OARs by 54% and 26%, respectively. Moreover, the low dose bath expressed as V 10% to normal tissue is substantially reduced by up to 45% compared to the VMAT plans. A TPP for MBRT including simultaneous optimization is successfully implemented and the dosimetric superiority of MBRT plans over MERT, photon IMRT and VMAT plans is demonstrated for academic and clinical situations including superficial targets with and without deep-seated part.

Chemical diversity of labdane-type bicyclic diterpene biosynthesis in Actinomycetales microorganisms.

PubMed

Yamada, Yuuki; Komatsu, Mamoru; Ikeda, Haruo

2016-07-01

Five pairs of bacterial type-A and type-B diterpene synthases have been characterized: BAD86798/BAD86797, AHK61133/AHK61132, BAB39207/BAB39206, CldD/CldB and RmnD/RmnB, and are involved in the formation of pimara-9(11),15-diene, terpente-3,13,15-triene and labda-8(17),12(E),14-triene. Mining of bacterial genome data revealed an additional four pairs of type-A and type-B diterpene synthases: Sros_3191/Sros_3192 of Streptosporangium roseum DSM 43021, Sare_1287/Sare_1288 of Salinispora arenicola CNS-205, SCLAV_5671/SCLAV_5672 and SCLAV_p0491/SCLAV_p0490 of Streptomyces clavuligerus ATCC 27064. Since SCLAV_p0491/SCLAV_p0490 is similar to the labdane-type diterpene synthase pairs, CldD/CldB and RmnD/RmnB based on the alignment of the deduced amino acid sequences and phylogenetic analyses of the aligned sequences, these predicted diterpene synthases were characterized by an enzymatic reaction using a pair of recombinant type-A and type-B diterpene synthases prepared in Escherichia coli and the heterologous expression of two genes encoding type-A and type-B diterpene synthases in an engineered Streptomyces host. The generation of labda-8(17),12(E),14-triene (1) by CldB and CldD was reconfirmed by enzymatic synthesis. Furthermore, labda-8(17),13(16),14-triene (2) was generated by SCLAV_p0491 and CldB, and ladba-7,12(E),14-triene (3) by CldD and SCLAV_p0490. SCLAV_p0491 and SCLAV_p0490 catalyzed the generation of the novel diterpene hydrocarbon, labda-7,13(16),14-triene (4).

Countrywide digital elevation models for the Islamic Republic of Mauritania—SRTM and ASTER (phase V, deliverable 65): Chapter F in Second projet de renforcement institutionnel du secteur minier de la République Islamique de Mauritanie (PRISM-II)

USGS Publications Warehouse

Lee, Gregory K.

2015-01-01

A digital elevation model (DEM) of the entire country of the Islamic Republic of Mauritania was produced using Shuttle Radar Topography Mission (SRTM) data as required for deliverable 65 of the contract. In addition, because of significant recent advancements of availability, seamlessness, and validity of Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER) global elevation data, the U.S. Geological Survey (USGS) extended its efforts to include a higher resolution countrywide ASTER DEM as value added to the required Deliverable 63, which was limited to five areas within the country. Both SRTM and ASTER countrywide DEMs have been provided in ERDAS Imagine (.img) format that is also directly compatible with ESRI ArcMap, ArcGIS Explorer, and other GIS applications.

76 FR 33565 - Medicare Program; Availability of Medicare Data for Performance Measurement

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-08

... data from two or more other sources. For example, a qualified entity would need to have claims data... help further alleviate some of the methodological issues associated with performance measurement based... Medicare parts A, B, and D claims data available to the qualified entity. For example, several measures in...

26 CFR 1.460-0 - Outline of regulations under section 460.

Code of Federal Regulations, 2014 CFR

2014-04-01

...) Examples. § 1.460-2Long-term manufacturing contracts. (a) In general. (b) Unique. (1) In general. (2) Safe... complete. (1) In general. (2) Production by related parties. (d) Qualified ship contracts. (e) Examples... improvements. (iv) Mixed use costs. (3) $10,000,000 gross receipts test. (i) In general. (ii) Single employer...

26 CFR 1.460-0 - Outline of regulations under section 460.

Code of Federal Regulations, 2012 CFR

2012-04-01

...) Examples. § 1.460-2Long-term manufacturing contracts. (a) In general. (b) Unique. (1) In general. (2) Safe... complete. (1) In general. (2) Production by related parties. (d) Qualified ship contracts. (e) Examples... improvements. (iv) Mixed use costs. (3) $10,000,000 gross receipts test. (i) In general. (ii) Single employer...

26 CFR 1.460-0 - Outline of regulations under section 460.

Code of Federal Regulations, 2010 CFR

2010-04-01

...) Examples. § 1.460-2Long-term manufacturing contracts. (a) In general. (b) Unique. (1) In general. (2) Safe... complete. (1) In general. (2) Production by related parties. (d) Qualified ship contracts. (e) Examples... improvements. (iv) Mixed use costs. (3) $10,000,000 gross receipts test. (i) In general. (ii) Single employer...

26 CFR 1.460-0 - Outline of regulations under section 460.

Code of Federal Regulations, 2011 CFR

2011-04-01

...) Examples. § 1.460-2Long-term manufacturing contracts. (a) In general. (b) Unique. (1) In general. (2) Safe... complete. (1) In general. (2) Production by related parties. (d) Qualified ship contracts. (e) Examples... improvements. (iv) Mixed use costs. (3) $10,000,000 gross receipts test. (i) In general. (ii) Single employer...

26 CFR 1.482-1 - Allocation of income and deductions among taxpayers.

Code of Federal Regulations, 2013 CFR

2013-04-01

... determining the comparability of two transactions include— (A) Research and development; (B) Product design... illustrates the principles of this paragraph (d)(4)(ii)(C). Example. Couture, a U.S. apparel design....482-8 provides examples illustrating the application of the best method rule. Finally, § 1.482-9...

26 CFR 1.482-1 - Allocation of income and deductions among taxpayers.

Code of Federal Regulations, 2012 CFR

2012-04-01

... determining the comparability of two transactions include— (A) Research and development; (B) Product design... illustrates the principles of this paragraph (d)(4)(ii)(C). Example. Couture, a U.S. apparel design....482-8 provides examples illustrating the application of the best method rule. Finally, § 1.482-9...

26 CFR 1.482-1 - Allocation of income and deductions among taxpayers.

Code of Federal Regulations, 2014 CFR

2014-04-01

... determining the comparability of two transactions include— (A) Research and development; (B) Product design... illustrates the principles of this paragraph (d)(4)(ii)(C). Example. Couture, a U.S. apparel design....482-8 provides examples illustrating the application of the best method rule. Finally, § 1.482-9...

26 CFR 1.482-1 - Allocation of income and deductions among taxpayers.

Code of Federal Regulations, 2011 CFR

2011-04-01

... determining the comparability of two transactions include— (A) Research and development; (B) Product design... illustrates the principles of this paragraph (d)(4)(ii)(C). Example. Couture, a U.S. apparel design....482-8 provides examples illustrating the application of the best method rule. Finally, § 1.482-9...

26 CFR 1.962-3 - Treatment of actual distributions.

Code of Federal Regulations, 2010 CFR

2010-04-01

... classified under § 1.959-3 and this section for purposes of section 962(d) as follows: Classification of... purposes of a section 959(c) amount and year classification under paragraph (b) of § 1.959-3, a... Revenue Code. The application of this subparagraph may be illustrated by the following example: Example...

26 CFR 1.962-3 - Treatment of actual distributions.

Code of Federal Regulations, 2011 CFR

2011-04-01

... classified under § 1.959-3 and this section for purposes of section 962(d) as follows: Classification of... purposes of a section 959(c) amount and year classification under paragraph (b) of § 1.959-3, a... Revenue Code. The application of this subparagraph may be illustrated by the following example: Example...

Influence of Ossicular Chain Damage on Hearing After Chronic Otitis Media and Cholesteatoma Surgery: A Systematic Review and Meta-analysis.

PubMed

Blom, Erik F; Gunning, Marlise N; Kleinrensink, Nienke J; Lokin, Alexander S H J; Bruijnzeel, Hanneke; Smit, Adriana L; Grolman, Wilko

2015-11-01

Physicians should ideally be able to provide patients with chronic otitis media and/or cholesteatoma specific information about postoperative hearing outcome, based on their level of preoperative ossicular chain damage (OCD). To identify the influence of preoperative OCD on hearing outcomes in patients after chronic otitis media and/or cholesteatoma surgery. PubMed, EMBASE, and the Cochrane Library databases were systematically searched for available evidence, without any constraints, on December 13, 2014, for articles published between January 1, 1975, and December 13, 2014. We reviewed the literature for articles assessing the prognostic value of OCD on postoperative hearing outcome (air-bone gap [ABG] in decibels), using Austin-Kartush criteria or independent OCD classification systems. We assessed relevance and validity using a self-designed critical appraisal tool based on the Cochrane Collaboration's risk of bias tool. Characteristics of study populations and postoperative ABGs in decibels were extracted from all included studies by 4 authors (E.F.B., M.N.G., N.J.K., A.S.H.J.L.). The tested hypothesis was formulated before data collection. Primary study outcome was defined as postoperative adult hearing outcomes after COM and/or cholesteatoma surgery defined as mean postoperative ABG. Our search yielded 5661 articles. Nine articles with high relevance were included. Pooled results of studies using the Austin-Kartush criteria showed a significant (P < .001) difference in mean ABG in favor of group B, when comparing group B (patients with malleus present, stapes absent; 11.1 [95% CI, 10.3-11.8] dB) to group C (patients with malleus absent, stapes present; 15.7 [95% CI, 14.6-16.7] dB) and group B to group D (patients with malleus absent, stapes absent; 16.5 [95% CI, 15.2-17.9] dB). Three studies using independent OCD classification criteria found no influence of stapes structure (intact stapes suprastructure, 13.5 [95% CI, 10.3-16.7], 15.1 [95% CI, 11.8-18.3], and 21.9 [95% CI, 15.0-28.8] dB vs absent stapes structure, 12.8 [95% CI, 9.5-16.1], 19.5 [95% CI, 14.9-24.1], and 30.2 [95% CI, 24.7-35.8] dB) on postoperative ABG. One study reported a significant (P = .04) difference in mean ABG between patients with present (18.9 [95% CI, 15.7-22.1] dB) and absent (24.4 [95% CI, 20.2-28.6] dB) malleus. Pooled results of Austin-Kartush studies showed that in patients with COM, with or without cholesteatoma, the malleus status is a significant predictor of postoperative hearing outcome, independent of the stapes condition. Studies reporting on individual ossicle status supported this finding by showing that only malleus condition influenced postoperative hearing outcome. These findings are based on level IV evidence, which indicates the need for future high-level evidence studies.

Crystalline basement map of Mauritania derived from filtered aeromagnetic data (deliverable 54_1), Aeromagnetic and geological structure map of Mauritania (phase V, deliverable 54_2), Maximum depth to basement map of Mauritania derived from Euler analysis of Aeromagnetic data (phase V, deliverable 54_3), and color composite image of radioelement data (added value): Chapter B1 in Second projet de renforcement institutionnel du secteur minier de la République Islamique de Mauritanie (PRISM-II)

USGS Publications Warehouse

Finn, Carol A.; Horton, John D.

2015-01-01

This report contains the USGS results of the PRISM-II Mauritania Minerals Project and is presented in cooperation with the Ministry of Petroleum, Energy, and Mines of the Islamic Republic of Mauritania. The Report is composed of separate chapters consisting of multidisciplinary interpretive reports with accompanying plates on the geology, structure, geochronology, geophysics, hydrogeology, geochemistry, remote sensing (Landsat TM and ASTER), and SRTM and ASTER digital elevation models of Mauritania. The syntheses of these multidisciplinary data formed the basis for additional chapters containing interpretive reports on 12 different commodities and deposit types known to occur in Mauritania, accompanied by countrywide mineral resource potential maps of each commodity/deposit type. The commodities and deposit types represented include: (1) Ni, Cu, PGE, and Cr deposits hosted in ultramafic rocks; (2) orogenic, Carlin-like, and epithermal gold deposits; (3) polymetallic Pb-Zn-Cu vein deposits; (4) sediment-hosted Pb-Zn-Ag deposits of the SEDEX and Mississippi Valley-type; (5) sediment-hosted copper deposits; ( 6) volcanogenic massive sulfide deposits; (7) iron oxide copper-gold deposits; (8) uranium deposits; (9) Algoma-, Superior-, and oolitic-type iron deposits; (10) shoreline Ti-Zr placer deposits; (11) incompatible element deposits hosted in pegmatites, alkaline rocks, and carbonatites, and; (12) industrial mineral deposits. Additional chapters include the Mauritanian National Mineral Deposits Database are accompanied by an explanatory text and the Mauritania Minerals Project GIS that contains all of the interpretive layers created by USGS scientists. Raw data not in the public domain may be obtained from the Ministry of Petroleum, Energy, and Mines in Nouakchott, Mauritania.

Time domain reshuffling for OFDM based indoor visible light communication systems.

PubMed

You, Xiaodi; Chen, Jian; Yu, Changyuan; Zheng, Huanhuan

2017-05-15

For orthogonal frequency division multiplexing (OFDM) based indoor visible light communication (VLC) systems, partial non-ideal transmission conditions such as insufficient guard intervals and a dispersive channel can result in severe inter-symbol crosstalk (ISC). By deriving from the inverse Fourier transform, we present a novel time domain reshuffling (TDR) concept for both DC-biased optical (DCO-) and asymmetrically clipped optical (ACO-) OFDM VLC systems. By using only simple operations in the frequency domain, potential high peaks can be relocated within each OFDM symbol to alleviate ISC. To simplify the system, we also propose an effective unified design of the TDR schemes for both DCO- and ACO-OFDM. Based on Monte-Carlo simulations, we demonstrate the statistical distribution of the signal high peak values and the complementary cumulative distribution function of the peak-to-average power ratio under different cases for comparison. Simulation results indicate improved bit error rate (BER) performance by adopting TDR to counteract ISC deterioration. For example, for binary phase shift keying at a BER of 10 -3 , the signal to noise ratio gains are ~1.6 dB and ~6.6 dB for DCO- and ACO-OFDM, respectively, with ISC of 1/64. We also show a reliable transmission by adopting TDR for rectangle 8-quadrature amplitude modulation with ISC of < 1/64.

Effects of major histocompatibility complex class II knockout on mouse bone mechanical properties during development

NASA Technical Reports Server (NTRS)

Simske, Steven J.; Bateman, Ted A.; Smith, Erin E.; Ferguson, Virginia L.; Chapes, Stephen K.

2002-01-01

We investigated the effect of major histocompatibility complex class II (MHC II) knockout on the development of the mouse peripheral skeleton. These C2D mice had less skeletal development at 8, 12 and 16 weeks of age compared to wild-type C57BL/6J (B6) male mice. The C2D mice had decreased femur mechanical, geometric and compositional measurements compared to wild type mice at each of these ages. C2D femur stiffness (S), peak force in 3-pt bending (Pm), and mineral mass (Min-M) were 74%, 64% and 66%, respectively, of corresponding B6 values at 8 weeks of age. Similar differences were measured at 12 weeks (for which C2D femoral S, Pm and Min-M were 71%, 72% and 73%, respectively, of corresponding B6 values) and at 16 weeks (for which C2D femoral S, Pm and Min-M were 80%, 66% and 61%, respectively, of corresponding B6 values). MHC II knockout delays the development of adult bone properties and is accompanied by lower body mass compared to wild-type controls.

Human Health Countermeasures (HHC) Element Management Plan: Human Research Program. Revision B

NASA Technical Reports Server (NTRS)

Norsk, Peter; Baumann, David

2012-01-01

NASA s Human Research Program (HRP) is an applied research and technology program within the Human Exploration and Operations Mission Directorate (HEOMD) that addresses human health and performance risk mitigation strategies in support of exploration missions. The HRP research and technology development is focused on the highest priority risks to crew health and safety with the goal of ensuring mission success and maintaining long-term crew health. Crew health and performance standards, defined by the NASA Chief Health and Medical Officer (CHMO), set the acceptable risk level for exploration missions. The HRP conducts research to inform these standards as well as provide deliverables, such as countermeasures, that ensure standards can be met to maximize human performance and mission success. The Human Health Countermeasures (HHC) Element was formed as part of the HRP to develop a scientifically-based, integrated approach to understanding and mitigating the health risks associated with human spaceflight. These health risks have been organized into four research portfolios that group similar or related risks. A fifth portfolio exists for managing technology developments and infrastructure projects. The HHC Element portfolios consist of: a) Vision and Cardiovascular; b) Exercise and Performance; c) Multisystem; d) Bone; and e) Technology and Infrastructure. The HHC identifies gaps associated with the health risks and plans human physiology research that will result in knowledge required to more fully understand risks and will result in validated countermeasures to mitigate risks.

Small Volume Fuel Testers Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Schoegl, I.; McNenly, M. J.; Killingsworth, N. J.

Micro-liter fuel ignition testing (μ-FIT) is based on the premise that characteristics FREI (Flames with Repetitive Extinction and Ignition, i.e. cyclically occurring combustion events within heated capillaries), are linked to fuel properties. In early FY16, proof-of-concept measurements with primary reference fuel (PRF) mixtures, i.e. blends of n-heptane and iso-octane, yielded clear evidence for the feasibility of the approach. Our experiments showed that it is critical to accurately link observed flame positions to local temperatures, which provides information on ignition, extinction and flame propagation, all of which are known to be impacted by fuel properties. In FY16, one major hurdle wasmore » uncertainty of temperature calibration, which required significant efforts for corrective action that were not included in the original scope of work. Temperature calibrations are obtained by translating a thermocouple within the capillary in absence of a flame. While measurements have good repeatability when accounting for transient and insertion effects, results from nominally identical thermocouples reveal unacceptable uncertainty (up to ±50K), which is attributed to variations in thermocouple placement and manufacturing tolerances. This issue is currently being resolved by switching to non-intrusive optical temperature measurements. Updates are expected to yield uncertainties of less than ±10K, while also eliminating transient and insertion effects. The experimental work was complemented by computational efforts where it was shown that a simplified Lagrangian zero-D model with detailed kinetics yields fuelspecific differentiation of ignition temperatures for simple fuels that are consistent with experiments. Further, a 2D transient model was implemented in OpenFOAM to investigate combustion behavior of simple fuels at elevated pressure. In an upcoming visit to LLNL, more advanced simulations using LLNL’s computational tools (e.g. zero-RK) are planned, which will yield additional numerical insights on FREI behavior of more realistic spark ignited (SI) engine fuel surrogates. As there is a lag between DOE FY16 and the time frame of the LSU subcontract, it is anticipated that deliverables outlined in the scope of work will be met by the end of the subcontract (January 2017).« less

Design, synthesis and biological evaluation of 7H-pyrrolo[2,3-d]pyrimidin-4-amine derivatives as selective Btk inhibitors with improved pharmacokinetic properties for the treatment of rheumatoid arthritis.

PubMed

He, Linhong; Pei, Heying; Zhang, Chufeng; Shao, Mingfeng; Li, Dan; Tang, Mingli; Wang, Taijing; Chen, Xiaoxin; Xiang, Mingli; Chen, Lijuan

2018-02-10

Bruton's tyrosine kinase (Btk) is a Tec family kinase with a well-defined role in the B cell receptor (BCR) and Fcγ receptor (FcR) signaling pathways, which makes it a uniquely attractive target for the treatment of autoimmune diseases, such as rheumatoid arthritis (RA). We reported a series of compounds bearing 7H-pyrrolo [2,3-d]pyrimidin-4-amine scaffold that potently inhibited Btk in vitro. Analysis of the structure-activity relationships (SAR) and drug-like profiles led to the discovery of the optimal compound B16. B16 preferentially inhibited Btk (IC 50  = 21.70 ± 0.82 nM) over closely related kinases with moderate selectivity. Cell-based tests also confirmed that B16 significantly inhibited Btk Y223 auto-phosphorylation and PLCγ2 Y1217 phosphorylation. MTT revealed that B16 displayed weak suppression against normal LO2, HEK293 and THP-1 cell lines with IC 50 values over 30 μM. Moreover, B16 showed very weak potential to block the hERG channel (IC 50  = 11.10 μM) in comparison to ibrutinib (IC 50  = 0.97 μM). Owing to its favorable physicochemical properties (ClogP = 2.53, aqueous solubility ≈ 0.1 mg/mL), pharmacokinetic profiles (F = 49.15%, t 1/2  = 7.02 h) and reasonable CYP450 profile, B16 exhibited potent anti-arthritis activity and similar efficacy to ibrutinib in reducing paw thickness in CIA mice. In conclusion, B16 is a potent, selective and durable inhibitor of Btk and has the potential to a safe and efficacious treatment for arthritis. Copyright © 2017 Elsevier Masson SAS. All rights reserved.

Infection with hepatitis A, B, C, and delta viruses among patients with acute hepatitis in Mongolia.

PubMed

Tsatsralt-Od, Bira; Takahashi, Masaharu; Endo, Kazunori; Buyankhuu, Osorjin; Baatarkhuu, Oidov; Nishizawa, Tsutomu; Okamoto, Hiroaki

2006-05-01

One hundred ten consecutive patients (60 males and 50 females; age, mean +/- standard deviation [SD], 22.6 +/- 6.4 years; range 16-48 years) who were clinically diagnosed with sporadic acute hepatitis between December 2004 and January 2005 in Ulaanbaatar, Mongolia, were studied. IgM antibodies to hepatitis A virus were detected in 18 patients (16.4%), IgM antibodies to hepatitis B core (anti-HBc IgM) in 38 patients (34.5%) including two patients with concurrent hepatitis delta virus (HDV) infection, and hepatitis C virus RNA in nine patients (8.2%). There were 30 hepatitis B virus (HBV) carriers who had detectable hepatitis B surface antigen and antibodies to HDV but were negative for anti-HBc IgM, suggesting that they acquired type D acute hepatitis due to superinfection of HDV on a background of chronic HBV infection. None had IgM antibodies to hepatitis E virus (HEV). Consequently, 16.4, 32.7, 6.4, 1.8, and 27.3% of the patients were diagnosed as having acute hepatitis of type A, B, C, type B + D (HBV/HDV coinfection), and type D (superinfection of HDV), respectively. The cause of hepatitis was not known in the remaining 17 patients (15.5%). All 18 HAV isolates were genotyped as IA, all 9 HCV isolates were genotyped as 1b, and all 32 HDV isolates were classified into genotype I. The distribution of HBV genotypes among the 67 HBV isolates was A (1.5%, n = 1) and D (98.5%, n = 66). The present study indicates that de novo infections of HAV, HBV, HCV, and HDV are prevalent among young adults in Mongolia. Copyright 2006 Wiley-Liss, Inc.

Potential ability of hot water adzuki (Vigna angularis) extracts to inhibit the adhesion, invasion, and metastasis of murine B16 melanoma cells.

PubMed

Itoh, Tomohiro; Umekawa, Hayato; Furuichi, Yukio

2005-03-01

The 40% ethanol eluent of the fraction of hot-water extract from adzuki beans (EtEx.40) adsorbed onto DIAION HP-20 resin has many biological activities, for example, antioxidant, antitumorigenesis, and intestinal alpha-glucosidase suppressing activities. This study examined the inhibitory effect of EtEx.40 on experimental lung metastasis and the invasion of B16-BL6 melanoma cells. EtEx.40 was found significantly to reduce the number of tumor colonies. It also inhibited the adhesion and migration of B16-BL6 melanoma cells into extracellular matrix components and their invasion into reconstituted basement membrane (matrigel) without affecting cell proliferation in vitro. These in vivo data suggest that EtEx.40 possesses a strong antimetastatic ability, which might be a lead compound in functional food development.

Clinical trial: phase 2 study of lubiprostone for irritable bowel syndrome with constipation.

PubMed

Johanson, J F; Drossman, D A; Panas, R; Wahle, A; Ueno, R

2008-04-01

Analyses of a trial in constipated patients indicated that lubiprostone may be an effective treatment for irritable bowel syndrome with constipation. To assess the efficacy and safety of three lubiprostone doses for irritable bowel syndrome with constipation. 195 irritable bowel syndrome with constipation patients received daily doses of 16 [8 microg twice daily (b.d.)], 32 (16 microg b.d.) or 48 microg (24 microg b.d.) lubiprostone or placebo b.d. for 3 months. Gastrointestinal parameters were recorded in diaries daily by patients. After 1 month, lubiprostone showed significantly greater improvements in mean abdominal discomfort/pain scores vs. placebo (P = 0.023). After 2 months, all lubiprostone groups showed significantly greater improvements in mean abdominal discomfort/pain scores (P < or = 0.039). After 3 months of treatment, the improvement in each lubiprostone arm was greater than placebo, but the test for trend was no longer significant. Treatment with lubiprostone showed significantly higher rates of gastrointestinal adverse events (P = 0.020), especially diarrhoea and nausea. Lubiprostone significantly improved gastrointestinal symptoms of irritable bowel syndrome with constipation at all doses. Higher doses of lubiprostone, especially the 48 microg/day group, were associated with more gastrointestinal adverse events. From these data, the 16 microg/day dose demonstrated the optimal combination of efficacy and safety. These results warrant further study of lubiprostone for treatment of irritable bowel syndrome with constipation patients.

Ectopic expression of TaOEP16-2-5B, a wheat plastid outer envelope protein gene, enhances heat and drought stress tolerance in transgenic Arabidopsis plants.

PubMed

Zang, Xinshan; Geng, Xiaoli; Liu, Kelu; Wang, Fei; Liu, Zhenshan; Zhang, Liyuan; Zhao, Yue; Tian, Xuejun; Hu, Zhaorong; Yao, Yingyin; Ni, Zhongfu; Xin, Mingming; Sun, Qixin; Peng, Huiru

2017-05-01

Abiotic stresses, such as heat and drought, are major environmental factors restricting crop productivity and quality worldwide. A plastid outer envelope protein gene, TaOEP16-2, was identified from our previous transcriptome analysis [1,2]. In this study, the isolation and functional characterization of the TaOEP16-2 gene was reported. Three homoeologous sequences of TaOEP16-2 were isolated from hexaploid wheat, which were localized on the chromosomes 5A, 5B and 5D, respectively. These three homoeologues exhibited different expression patterns under heat stress conditions, TaOEP16-2-5B was the dominant one, and TaOEP16-2-5B was selected for further analysis. Compared with wild type (WT) plants, transgenic Arabidopsis plants overexpressing the TaOEP16-2-5B gene exhibited enhanced tolerance to heat stress, which was supported by improved survival rate, strengthened cell membrane stability and increased sucrose content. It was also found that TaOEP16-2 was induced by drought stress and involved in drought stress tolerance. TaOEP16-2-5B has the same function in ABA-controlled seed germination as AtOEP16-2. Our results suggest that TaOEP16-2-5B plays an important role in heat and drought stress tolerance, and could be utilized in transgenic breeding of wheat and other crop plants. Copyright © 2017 Elsevier B.V. All rights reserved.

NASA Subsonic Jet Transport Noise Reduction Research

DTIC Science & Technology

2000-09-01

optical and acoustical interference. Figure 7 shows the concept and data from the installation of arrays of Herschel- Quincke tubes in the duct...tube row 16 tube row Herschel- Quincke Tube Tube length 12.5cm d = 3.8cm L = 9.2cm 2250 2350 2450 2500...Blade passage frequency, Hz R el at iv e p o w er , d B JT15D Turbofan Engine 4 d B Figure 7. Application of Herschel- Quincke tubes for

Tofacitinib for the treatment of moderate to severe chronic plaque psoriasis in Japanese patients: Subgroup analyses from a randomized, placebo-controlled phase 3 trial.

PubMed

Abe, Masatoshi; Nishigori, Chikako; Torii, Hideshi; Ihn, Hironobu; Ito, Kei; Nagaoka, Makoto; Isogawa, Naoki; Kawaguchi, Isao; Tomochika, Yukiko; Kobayashi, Mihoko; Tallman, Anna M; Papp, Kim A

2017-11-01

Tofacitinib is an oral Janus kinase inhibitor. These post-hoc analyses assessed tofacitinib efficacy and safety in Japanese patients with psoriasis enrolled in a 52-week global phase 3 study. Patients received tofacitinib 5 mg, tofacitinib 10 mg or placebo twice daily (b.i.d.); placebo-treated patients advanced to tofacitinib at week 16. Primary efficacy end-points were the proportions of patients with 75% or more reduction from baseline Psoriasis Area and Severity Index (PASI-75) and Physician's Global Assessment (PGA) of "clear" or "almost clear" (PGA response) at week 16. Other end-points included: Itch Severity Item (ISI), Dermatology Life Quality Index (DLQI) score and Nail Psoriasis Severity Index (NAPSI). Adverse events (AEs) were recorded throughout the study. Overall, 58 Japanese patients were included in this analysis (tofacitinib 5 mg b.i.d., n = 22; 10 mg b.i.d., n = 24; placebo, n = 12); 29 completed the study. At week 16, significantly more patients receiving tofacitinib 5 and 10 mg b.i.d. versus placebo achieved PASI-75 (50% and 75% vs 0%, P < 0.01) and PGA response (59% and 75% vs 0%, P < 0.001). Substantial improvements in ISI, DLQI and NAPSI score were observed with both tofacitinib doses. Over 52 weeks, similar rates of AEs were reported across treatment groups; one serious AE occurred with tofacitinib 10 mg b.i.d. Herpes zoster occurred in three patients receiving tofacitinib 10 mg b.i.d. No deaths, serious infections, malignancies or gastrointestinal perforations were reported. Results were generally consistent with global analysis, suggesting sustained efficacy and a manageable safety profile, with increased herpes zoster incidence, of tofacitinib in Japanese patients with psoriasis. © 2017 The Authors. The Journal of Dermatology published by John Wiley & Sons Australia, Ltd on behalf of Japanese Dermatological Association.

Diode Laser Stapedotomy vs Conventional Stapedotomy in Otosclerosis: A Double-Blinded Randomized Clinical Trial.

PubMed

Parida, Pradipta Kumar; Kalaiarasi, Raja; Gopalakrishnan, Surianarayana

2016-06-01

To assess and compare the efficacy of diode laser stapedotomy (DLS) and conventional manual stapedotomy (CMS) in the treatment of otosclerosis. Randomized clinical trial. Tertiary health center. We randomly assigned 60 patients with otosclerosis planned for primary stapedotomy to receive either DLS or CMS. Primary outcome measure was hearing gain measured by pure-tone audiometry (PTA) performed preoperatively and postoperatively. Hearing gain was compared within and between the groups. Secondary outcome measures were the incidence of intraoperative (bleeding and fractured footplate) and postoperative (vomiting, vertigo, sensorineural hearing loss, tinnitus, facial nerve paralysis, and hospital stay) morbidities. Sixty primary stapedotomies (30 in the CMS group and 30 in the DLS group) done for 60 patients (male, n = 42; female, n = 18) were included in the analysis. Preoperative mean air-bone (AB) gap in the DLS and CMS groups was 38.51 ± 8.643 dB and 36.42 ± 8.678 dB, respectively. Mean AB gap at 6 month was 10.86 ± 5.383 dB and 11.05 ± 5.236 dB in the CMS and DLS groups, respectively. Air conduction was improved by 24.98 ± 5.348 dB in the DLS group and 24.08 ± 5.911 dB in the CMS group at 6 months. No statistically significant differences were found in hearing gain between the 2 groups at 6 months (P > .05). A decreased rate and severity of intraoperative bleeding, postoperative vertigo, and vomiting were observed with the diode laser (0%, 6.6%, and 10%) compared with the conventional technique (16.7%, 16.7%, and 16.7%), but these differences were not statistically significant (P > .05). Hearing outcomes and complications of DLS were similar to CMS. These study findings confirm the efficacy of the diode laser in stapedotomy, but DLS offers no advantages over CMS for otosclerosis surgery. © American Academy of Otolaryngology—Head and Neck Surgery Foundation 2016.

Absorption Analysis Applied to Neutrons in a Thermal Column

DTIC Science & Technology

1960-11-01

determined experimentally, 4’ . can be obtained from the inverse transform of A(B). The desired quantity, f (E) , is then obtained by use of Eq. (7); f(E-dE...where a and d were found to be 16. 76 and 0. 0256, respectively. This transform is also found in Table 1. The inverse transform of Eq. (20) is 2:d-e...yielded this fit was [b F-b fx -ax] T(x)--.e 1.1 Equation 1. 1 yielded the inverse transform , Ŕ when (I-a)(0 S(71) =, b e[b4c- c(2-a)- 4(Z-a)] 1.2 e

Symposium on Molecular Spectroscopy (44th) Held in Columbus, Ohio on 12- 16 June 1989

DTIC Science & Technology

1989-06-01

California, 94025. FC4. A PARTIAL DIFFERENTIAL EQUATION FOR THE RKR INTEGRAL ........................ 15 min.(9:21) D. L. HUESTIS, Molecular Physics...above have been analyzed further. We define effective constants by the following equations : Beff(v4 ,o) - B - B + nb(i/2)<cos(67)> + b<P72 > DJeff(v4...a) - D J - DJ + ndj(l/2)<cos(6j)> +edj<P72> D J K - D J K + "djk(l/2)<cos(6y)> + djk<Py 2>. In these equations , <..> are the diagonal values of

The Spanish biology/disease initiative within the human proteome project: Application to rheumatic diseases.

PubMed

Ruiz-Romero, Cristina; Calamia, Valentina; Albar, Juan Pablo; Casal, José Ignacio; Corrales, Fernando J; Fernández-Puente, Patricia; Gil, Concha; Mateos, Jesús; Vivanco, Fernando; Blanco, Francisco J

2015-09-08

The Spanish Chromosome 16 consortium is integrated in the global initiative Human Proteome Project, which aims to develop an entire map of the proteins encoded following a gene-centric strategy (C-HPP) in order to make progress in the understanding of human biology in health and disease (B/D-HPP). Chromosome 16 contains many genes encoding proteins involved in the development of a broad range of diseases, which have a significant impact on the health care system. The Spanish HPP consortium has developed a B/D platform with five programs focused on selected medical areas: cancer, obesity, cardiovascular, infectious and rheumatic diseases. Each of these areas has a clinical leader associated to a proteomic investigator with the responsibility to get a comprehensive understanding of the proteins encoded by Chromosome 16 genes. Proteomics strategies have enabled great advances in the area of rheumatic diseases, particularly in osteoarthritis, with studies performed on joint cells, tissues and fluids. In this manuscript we describe how the Spanish HPP-16 consortium has developed a B/D platform with five programs focused on selected medical areas: cancer, obesity, cardiovascular, infectious and rheumatic diseases. Each of these areas has a clinical leader associated to a proteomic investigator with the responsibility to get a comprehensive understanding of the proteins encoded by Chromosome 16 genes. We show how the Proteomic strategy has enabled great advances in the area of rheumatic diseases, particularly in osteoarthritis, with studies performed on joint cells, tissues and fluids. This article is part of a Special Issue entitled: HUPO 2014. Copyright © 2015 Elsevier B.V. All rights reserved.

37 CFR 202.16 - Preregistration of copyrights.

Code of Federal Regulations, 2011 CFR

2011-07-01

.... 202.16 Section 202.16 Patents, Trademarks, and Copyrights COPYRIGHT OFFICE, LIBRARY OF CONGRESS... Open and Maintain a Deposit Account in the Copyright Office,” or write the Register of Copyrights, Copyright Office, Library of Congress, Washington, D.C. 20559. (B) Credit cards, debit cards and electronic...

37 CFR 202.16 - Preregistration of copyrights.

Code of Federal Regulations, 2010 CFR

2010-07-01

.... 202.16 Section 202.16 Patents, Trademarks, and Copyrights COPYRIGHT OFFICE, LIBRARY OF CONGRESS... Open and Maintain a Deposit Account in the Copyright Office,” or write the Register of Copyrights, Copyright Office, Library of Congress, Washington, D.C. 20559. (B) Credit cards, debit cards and electronic...

Absolute branching fraction measurements for D+ and D0 inclusive semileptonic decays.

PubMed

Adam, N E; Alexander, J P; Berkelman, K; Cassel, D G; Duboscq, J E; Ecklund, K M; Ehrlich, R; Fields, L; Gibbons, L; Gray, R; Gray, S W; Hartill, D L; Heltsley, B K; Hertz, D; Jones, C D; Kandaswamy, J; Kreinick, D L; Kuznetsov, V E; Mahlke-Krüger, H; Meyer, T O; Onyisi, P U E; Patterson, J R; Peterson, D; Pivarski, J; Riley, D; Ryd, A; Sadoff, A J; Schwarthoff, H; Shi, X; Stroiney, S; Sun, W M; Wilksen, T; Weinberger, M; Athar, S B; Patel, R; Potlia, V; Stoeck, H; Yelton, J; Rubin, P; Cawlfield, C; Eisenstein, B I; Karliner, I; Kim, D; Lowrey, N; Naik, P; Sedlack, C; Selen, M; White, E J; Wiss, J; Shepherd, M R; Besson, D; Pedlar, T K; Cronin-Hennessy, D; Gao, K Y; Gong, D T; Hietala, J; Kubota, Y; Klein, T; Lang, B W; Poling, R; Scott, A W; Smith, A; Dobbs, S; Metreveli, Z; Seth, K K; Tomaradze, A; Zweber, P; Ernst, J; Severini, H; Dytman, S A; Love, W; Savinov, V; Aquines, O; Li, Z; Lopez, A; Mehrabyan, S; Mendez, H; Ramirez, J; Huang, G S; Miller, D H; Pavlunin, V; Sanghi, B; Shipsey, I P J; Xin, B; Adams, G S; Anderson, M; Cummings, J P; Danko, I; Napolitano, J; He, Q; Insler, J; Muramatsu, H; Park, C S; Thorndike, E H; Coan, T E; Gao, Y S; Liu, F; Artuso, M; Blusk, S; Butt, J; Li, J; Menaa, N; Mountain, R; Nisar, S; Randrianarivony, K; Redjimi, R; Sia, R; Skwarnicki, T; Stone, S; Wang, J C; Zhang, K; Csorna, S E; Bonvicini, G; Cinabro, D; Dubrovin, M; Lincoln, A; Asner, D M; Edwards, K W; Briere, R A; Brock, I; Chen, J; Ferguson, T; Tatishvili, G; Vogel, H; Watkins, M E; Rosner, J L

2006-12-22

We present measurements of the inclusive branching fractions for the decays D+-->Xe+ nu(e) and D0-->Xe+ nu(e), using 281 pb(-1) of data collected on the psi(3770) resonance with the CLEO-c detector. We find B(D0-->Xe+ nu(e)) = (6.46+/-0.17+/-0.13)% and B(D+-->Xe+ nu(e)) = (16.13+/-0.20+/-0.33)%. Using the known D meson lifetimes, we obtain the ratio Gamma(D+)sl/Gamma(D0)sl = 0.985+/-0.028+/-0.015, confirming isospin invariance at the level of 3%. The positron momentum spectra from D+ and D0 have consistent shapes.

Final Report Extreme Computing and U.S. Competitiveness DOE Award. DE-FG02-11ER26087/DE-SC0008764

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mustain, Christopher J.

The Council has acted on each of the grant deliverables during the funding period. The deliverables are: (1) convening the Council’s High Performance Computing Advisory Committee (HPCAC) on a bi-annual basis; (2) broadening public awareness of high performance computing (HPC) and exascale developments; (3) assessing the industrial applications of extreme computing; and (4) establishing a policy and business case for an exascale economy.

Mechanics Methodology for Textile Preform Composite Materials

NASA Technical Reports Server (NTRS)

Poe, Clarence C., Jr.

1996-01-01

NASA and its contractors have completed a program to develop a basic mechanics underpinning for textile composites. Three major deliverables were produced by the program: 1. A set of test methods for measuring material properties and design allowables; 2. Mechanics models to predict the effects of the fiber preform architecture and constituent properties on engineering moduli, strength, damage resistance, and fatigue life; and 3. An electronic data base of coupon type test data. This report describes these three deliverables.

An ultra-compact and low loss passive beam-forming network integrated on chip with off chip linear array

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lepkowski, Stefan Mark

2015-05-01

The work here presents a review of beam forming architectures. As an example, the author presents an 8x8 Butler Matrix passive beam forming network including the schematic, design/modeling, operation, and simulated results. The limiting factor in traditional beam formers has been the large size dictated by transmission line based couplers. By replacing these couplers with transformer-based couplers, the matrix size is reduced substantially allowing for on chip compact integration. In the example presented, the core area, including the antenna crossover, measures 0.82mm×0.39mm (0.48% the size of a branch line coupler at the same frequency). The simulated beam forming achieves amore » peak PNR of 17.1 dB and 15dB from 57 to 63GHz. At the 60GHz center frequency the average insertion loss is simulated to be 3.26dB. The 8x8 Butler Matrix feeds into an 8-element antenna array to show the array patterns with single beam and adjacent beam isolation.« less

Frequency Management Engineering Principles--Spectrum Measurements (Reference Order 6050.23).

DTIC Science & Technology

1982-08-01

Interference 22 (a) Dielectric Heater Example 22 (b) High Power FM Interference Examle 22 (c) Radar Interference Example 22 (d) ARSR Interference Example...Localizer 23 (i) Dielectric Heaters 23 (j) High Power TV/FM 23 (k) Power Line Noise 23 (1) Incidental Radiating Devices 23 (m) Super-regenerative...employing broad band power amplifiers or and random spectrum analyzer instabilities traveling wave tubes. The "cleanest" spectrums create drift problems

75 FR 53908 - Method 16C for the Determination of Total Reduced Sulfur Emissions From Stationary Sources

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-02

...: Regulatory Planning and Review B. Paperwork Reduction Act C. Regulatory Flexibility Act D. Unfunded Mandates... disulfide. As described in Method 16A, the sample is collected from the source through a heated probe and..., October 4, 1993) and is therefore not subject to review under the EO. B. Paperwork Reduction Act This...

Metastatic melanoma cells escape from immunosurveillance through the novel mechanism of releasing nitric oxide to induce dysfunction of immunocytes.

PubMed

Zhang, X M; Xu, Q

2001-12-01

Nitric oxide (NO) is known to facilitate tumour metastasis through the promotion of angiogenesis, vascular dilation, platelet aggregation, etc. In the present study we explored its novel role in producing dysfunction of the host immune system in the metastasis of murine metastatic melanoma B16-BL6 cells. A significant reduction in the mixed lymphocyte reaction (MLR) was observed in the spleen cells from B16-BL6-bearing mice, but not in those from mice bearing the parent cell B16. When B16-BL6 cells were added in vitro to the MLR, a significant decrease was also found, even when they were co-cultured with the lymphocytes in two compartments of a Transwell chamber separated by an 8.0 microm filter. The supernatant from cultured B16-BL6 but not B16 cells, which had a greatly increased NO activity, significantly inhibited concanavalin A- and lipopolysaccharide-induced lymphocyte proliferation. A remarkably higher expression of inducible NO synthase (iNOS) was detected in B16-BL6 cells than in B16 cells. Nomega-Nitro-l-arginine (l-NNA), a NO synthase inhibitor and superoxide dismutase, significantly antagonized the above inhibition by B16-BL6 cells, while l-arginine, a NO precursor, and S-nitroso-N-acetyl-d,l-penicillamine, a NO donor, strengthened the inhibition. Furthermore, l-NNA significantly inhibited lung metastasis of B16-BL6 cells, while l-arginine tended to enhance the metastasis. The cytotoxicity of B16-BL6-specific T-cells was significantly decreased by pre-culture with B16-BL6 cells in a Transwell chamber or the culture supernatants of B16-BL6 cells, whereas l-iminoethyl-lysine, a selective inhibitor of iNOS, showed a significant recovery from the disease. These results suggest that NO released by metastatic tumour cells may impair the immune system, which facilitates the escape from immunosurveillance and metastasis of tumour cells.

Contribution of 3D printing to mandibular reconstruction after cancer.

PubMed

Dupret-Bories, A; Vergez, S; Meresse, T; Brouillet, F; Bertrand, G

2018-04-01

Three-dimensional (3D) printing is booming in the medical field. This technology increases the possibilities of personalized treatment for patients, while lowering manufacturing costs. To facilitate mandibular reconstruction with fibula free flap, some companies propose cutting guides obtained by CT-guided moulding. However, these guides are prohibitively expensive (€2,000 to €6,000). Based on a partnership with the CNRS, engineering students and a biomedical company, the authors have developed cutting guides and 3D-printed mandible templates, deliverable in 7days and at a lower cost. The novelty of this project is the speed of product development at a significantly lower price. In this technical note, the authors describe the logistic chain of production of mandible templates and cutting guides, as well as the results obtained. The goal is to allow access to this technology to all patients in the near future. Copyright © 2017 Elsevier Masson SAS. All rights reserved.

Hematinic deficiencies and pernicious anemia in oral mucosal disease patients with macrocytosis.

PubMed

Chang, Julia Yu-Fong; Wang, Yi-Ping; Wu, Yang-Che; Cheng, Shih-Jung; Chen, Hsin-Ming; Sun, Andy

2015-08-01

Macrocytosis is defined as having the mean corpuscular volume (MCV) ≥ 100 fL. This study assessed hematinic deficiencies and pernicious anemia (PA) in oral mucosal disease patients with macrocytosis. The blood hemoglobin (Hb), iron, vitamin B12, folic acid, and homocysteine concentrations and MCV in 60 oral mucosal disease patients with macrocytosis were measured and compared with the corresponding data in 120 age- and sex-matched healthy control participants. PA was defined by the World Health Organization (WHO) as having an Hb concentration < 13 g/dL for men and < 12 g/dL for women, an MCV ≥ 100 fL, a serum vitamin B12 level < 200 pg/mL, and serum gastric parietal cell antibody (GPCA) positivity. We found that 30 (50.0%), 7 (11.7%), 24 (40.0%), and three (5.0%) oral mucosal disease patients with macrocytosis had deficiencies of Hb (men < 13 g/dL, women < 12 g/dL), iron (< 60 μg/dL), vitamin B12 (< 200 pg/mL), and folic acid (< 4 mg/mL), respectively. Moreover, 38 (63.3%) and 16 (26.7%) macrocytosis patients had abnormally high blood homocysteine level (> 12.3 μM) and serum GPCA positivity, respectively. Macrocytosis patients had a significantly higher frequency of Hb, iron, or vitamin B12 deficiency, of abnormally elevated blood homocysteine level, and of GPCA positivity than healthy control participants (p < 0.001). However, only 16.7% of 60 macrocytosis patients were diagnosed as having PA by the WHO definition. Only 16.7% of oral mucosal disease patients with macrocytosis are discovered to have PA by the WHO definition. Copyright © 2015. Published by Elsevier B.V.

F-16X MSIP (Multi-National Staged Improvement Program) Case Example: Operating and Support Cost Estimation Using VAMOSC (Visibility and Management of Operating and Support Costs).

DTIC Science & Technology

1984-08-17

MODIFICATION-SPECIFIC RELIABILITY SCALAR DERIVATION A 8 C MOD LDZfl 11-R P-1F SI RZLaB.=l sUC NOD # 0g5SXpnflWIP rH SCALAR 1. 42DC 0822 Provide Direct 1964...WSSC Cost x F-16X MSIP Depot Avionics Maint.Mat F-16A Depot Avionics Maint.Materiel - $.028M x $81 297 liT2-2,000 = $. 103M /Squadron/Year C-1O DEPOT

Subliminal (latent) processing of pain and its evolution to conscious awareness

PubMed Central

Borsook, David; Youssef, Andrew M.; Barakat, Nadia; Sieberg, Christine B.; Elman, Igor

2018-01-01

By unconscious or covert processing of pain we refer to nascent interactions that affect the eventual deliverance of pain awareness. Thus, internal processes (viz., repeated nociceptive events, inflammatory kindling, re-organization of brain networks, genetic) or external processes (viz., environment, socioeconomic levels, modulation of epigenetic status) contribute to enhancing or inhibiting the presentation of pain awareness. Here we put forward the notion that for many patients, ongoing sub-conscious changes in brain function are significant players in the eventual manifestation of chronic pain. In this review, we provide clinical examples of nascent or what we term pre-pain processes and the neurobiological mechanisms of how these changes may contribute to pain, but also potential opportunities to define the process for early therapeutic interventions. PMID:29476771

Mineral potential for volcanogenic massive sulfide deposits in the Islamic Republic of Mauritania, (phase V, deliverable 77): Chapter L in Second projet de renforcement institutionnel du secteur minier de la République Islamique de Mauritanie (PRISM-II)

USGS Publications Warehouse

Taylor, Cliff D.; Giles, Stuart A.

2015-01-01

Potential for base- and precious-metal-bearing volcanogenic massive sulfide deposits (VMS) exists in Mauritania in the greenstone belts of the southwestern Rgueïbat Shield and in the allochthonous portions of the central and southern Mauritanides. Additional potential exists for VMS deposits within the Tiris Complex of the central Rgueïbat Shield. Volcanosedimentary successions of Paleoproterozoic rocks of the northeastern portion of the Rgueïbat Shield are also permissive for volcanogenic massive sulfide deposits. These types of mineral occurrences are common features of marine volcanosedimentary successions worldwide and can be of almost any age, although Proterozoic examples are less abundant.

Microgravity science experiment integration - When the PI and the PED differ

NASA Technical Reports Server (NTRS)

Baer-Peckham, M. S.; Mccarley, K. S.

1991-01-01

This paper addresses issues related to the integration of principal investigators (PIs) and payload-element developers (PEDs) for conducting effective microgravity experiments. The Crystal Growth Furnace (CGF) is used as an example to demonstrate the key issues related to the integration of a PI's sample into a facility run by a different organization. Attention is given to the typical preflight timeline, documentation required for experimental implementation, and hardware deliverables. A flow chart delineates the payload-integration process flow, and PI inputs required for an experiment include equipment and procedure definitions, detailed design and fabrication of the experiment-specific equipment, and specifications of the contract-end item. The present analysis is of interest to the coordination of effective microgravity experiments on the Space Station Freedom that incorporate PIs and PEDs from different organizations.

Geologic coal assessment: The interface with economics

USGS Publications Warehouse

Attanasi, E.D.

2001-01-01

Geologic resource assessments describe the location, general characteristics, and estimated volumes of resources, whether in situ or technically recoverable. Such compilations are only an initial step in economic resource evaluation. This paper identifies, by examples from the Illinois and Appalachian basins, the salient features of a geologic assessment that assure its usefulness to downstream economic analysis. Assessments should be in sufficient detail to allocate resources to production units (mines or wells). Coal assessments should include the spatial distribution of coal bed characteristics and the ability to allocate parts of the resource to specific mining technologies. For coal bed gas assessment, the production well recoveries and well deliverability characteristics must be preserved and the risk structure should be specified so dryholes and noncommercial well costs are recovered by commercially successful wells. ?? 2001 International Association for Mathematical Geology.

Subliminal (latent) processing of pain and its evolution to conscious awareness.

PubMed

Borsook, David; Youssef, Andrew M; Barakat, Nadia; Sieberg, Christine B; Elman, Igor

2018-05-01

By unconscious or covert processing of pain we refer to nascent interactions that affect the eventual deliverance of pain awareness. Thus, internal processes (viz., repeated nociceptive events, inflammatory kindling, reorganization of brain networks, genetic) or external processes (viz., environment, socioeconomic levels, modulation of epigenetic status) contribute to enhancing or inhibiting the presentation of pain awareness. Here we put forward the notion that for many patients, ongoing sub-conscious changes in brain function are significant players in the eventual manifestation of chronic pain. In this review, we provide clinical examples of nascent or what we term pre-pain processes and the neurobiological mechanisms of how these changes may contribute to pain, but also potential opportunities to define the process for early therapeutic interventions. Copyright © 2018. Published by Elsevier Ltd.

Acquiring General Iterative Concepts by Reformulating Explanations of Observed Examples.

DTIC Science & Technology

1987-12-01

CODES I&16 SUBJECT TERMS (Continue on revitn if nectsuty and identify by block number) FIELD GROUP SUE-GROUIP -, artificial intelligence, machine...N00014-86-K-0309, by the National Science Foundation under grant NSF IST 85-11542, and by a University of Illinois Cognitive Science/ Artificial ...Conference o, Arificiel InteLigence . pp 221-22> \\1ilan. 1 alv kugJsI I h Holder, L B., "Discovering Substructures in Examples," \\IS. Thesis (in preparation

16 CFR 801.1 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-01-01

... means an ultimate parent entity and all entities which it controls directly or indirectly. Examples: 1... parent corporations, subsidiaries and divisions (whether consolidated or unconsolidated, and whether... controls them is not an “entity” (see § 801.1(a)(2)). Corporations A and B* are the ultimate parent...

16 CFR 801.1 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-01-01

... means an ultimate parent entity and all entities which it controls directly or indirectly. Examples: 1... parent corporations, subsidiaries and divisions (whether consolidated or unconsolidated, and whether... controls them is not an “entity” (see § 801.1(a)(2)). Corporations A and B* are the ultimate parent...

16 CFR 801.1 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-01-01

... means an ultimate parent entity and all entities which it controls directly or indirectly. Examples: 1... parent corporations, subsidiaries and divisions (whether consolidated or unconsolidated, and whether... controls them is not an “entity” (see § 801.1(a)(2)). Corporations A and B* are the ultimate parent...

16 CFR 801.1 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-01-01

... means an ultimate parent entity and all entities which it controls directly or indirectly. Examples: 1... parent corporations, subsidiaries and divisions (whether consolidated or unconsolidated, and whether... controls them is not an “entity” (see § 801.1(a)(2)). Corporations A and B* are the ultimate parent...

16 CFR 801.1 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-01-01

... means an ultimate parent entity and all entities which it controls directly or indirectly. Examples: 1... parent corporations, subsidiaries and divisions (whether consolidated or unconsolidated, and whether... controls them is not an “entity” (see § 801.1(a)(2)). Corporations A and B* are the ultimate parent...

Pilot Aircraft Interface Objectives/Rationale

NASA Technical Reports Server (NTRS)

Shively, Jay

2010-01-01

Objective: Database and proof of concept for guidelines for GCS compliance a) Rationale: 1) Provide research test-bed to develop guidelines. 2) Modify GCS for NAS Compliance to provide proof of concept. b) Approach: 1) Assess current state of GCS technology. 2) Information Requirements Definition. 3) SME Workshop. 4) Modify an Existing GCS for NAS Compliance. 5) Define exemplar UAS (choose system to develop prototype). 6) Define Candidate Displays & Controls. 7) Evaluate/ refine in Simulations. 8) Demonstrate in flight. c) Deliverables: 1) Information Requirements Report. 2) Workshop Proceedings. 3) Technical Reports/ papers on Simulations & Flight Demo. 4) Database for guidelines.

Multidimensional Luminescence Measurements

DTIC Science & Technology

1985-04-30

Alfano , A.J.; Fong, E.K.; Lytle, F.E., Rev. S-.. Instrum. 1983, 54, 967-972. 7. HieftJe, G.M., Clin. Chem. 1983, 29, 1659-1664. 8. Berndt, K.; Durr...Miller, J.N., Trends Anal. Chem. 1981, 1, 31-34. ൗ. Warner, I.M.; Callis, J.B.; Christian , G.D.; Davidson, E.R., Anal. I TChem. 1977, 49, 564-573. 16...M.; Christian , G.D., Anal. Lett. 1975, 8, 665-681. 24. Johnson, D.W.; Gladden, J.A.; Callis, J.B.; Christian , G.D., Rev. Sci. Instrum. 1979, 50, 118

Engineering and management experience at Texas A&M Transportation Institute

NASA Astrophysics Data System (ADS)

Chowdhury, Arif Tahjibul

This manuscript presents the author's engineering and management experience during his internship in the Materials and Pavements (M&P) Division at the Texas A&M Transportation Institute (TTI), and is a record of study for the Doctor of Engineering at Texas A&M University. Through this internship, he met his established internship objectives of gaining technical knowledge as well as knowledge and skills in project management, organizational communication, and quality management of pavement condition data, and of attaining professional development. In meeting these objectives, the author describes the history, mission, and organizational structure of his workplace. He also presents his experience of developing and delivering a two-week training course on pavement design and construction in Kosovo. Participating in a number of professional development training courses and other activities prepared him for working as an engineering manager. These activities include Delta-T leadership training, an instructor development course, a time management and organizational skills course, and the M&P Division lecture series. Leadership and skills learned through the Delta-T program were beneficial for the employee as well as the employer. For the class project, the author and his teammates performed a study dealing with improving TTI's deliverables. The Delta-T team composed a report summarizing their efforts of examining the current state of TTI's project deliverables, the deliverables' shortcomings, and potential enhancements to expand the deliverables' appeal to additional types of potential users outside the traditional research community. The team also developed a prototype web-based model of deliverables and presented some implementation recommendations. Participating in the Texas Department of Transportation's (TxDOT's) pavement surface distress data collection program enabled the author to become familiar with pavement distress data quality management and thus attain the technical and nontechnical skills required for project management. He noticed some areas for improvement in TxDOT's rater's manual, rater's training class, and acceptance criteria for visual distress data.

Investigation of Differences Between Measured and Predicted Pressures in AEDC/VKF Hypersonic Tunnel B

DTIC Science & Technology

1997-01-01

coordinates are presented in Fig. 4b. The primary calibration data used in this paper is derived from the rake . The 42 pitot probes cov- ered a range...the lateral (YT) direction. Figures 5 and 6 show examples of the pitot pressure and total temperature rake data from a lateral survey and American...Figure 5. Rake pitot measurements, XT = 16 in. 0 10 YT, in. b. Local Mach number 20 Total Temperature Contours, R Static Temperature Contours, R

Army Facility Energy Demand and the Impact on National Security

DTIC Science & Technology

2007-03-30

grown from about $15B in 1995 to $46B in 2005.17 Iran’s annual oil revenues have increased approximately $30B (200%) compared with a decade ago...uses up 25 percent of the world’s annual energy production. Additionally, the United States currently imports 26 percent of its total energy supply...insurgent groups fighting U.S. forces.”16 Iran, Venezuela and Sudan are examples of countries that benefit from increased oil revenues , while at the

A Simple Ocean Bottom Hydrophone with 200 Megabyte Data Capacity

DTIC Science & Technology

1993-06-01

Securft Class (This Page) 22. Price (See ANSI- ZSM .18) S mlUdgn on Rwnes OPTIONAL FORM 272 (4-77) (Formerly NTIS- 35 ) Dewmenew ot Commerce ...gain if needed. The filtered signal is then fed in parallel to the input of two fixed gain amplifiers which provide gains of 9 dB and 35 dB...The values stored are the two gains and the two attenuation values - nominally + 35 , +9 -7 and -7 dB - see Figure 5. 16 Table 5: Checking the time of

Major East German plants enter EEC refining network

DOE Office of Scientific and Technical Information (OSTI.GOV)

Aalund, L.R.

1990-12-24

The reunification of Germany has brought some 22 million tons/year or 435,000 b/d of crude oil processing capacity into the European Economic Community from the former German Democratic Republic or East Germany. Most of this - 16.2 million tons or 323,000 b/d - comes from two refineries, PCK AG Schwedt and Leuna-Werke AG. Both have entered a period that will test their survival, at least as independent enterprises in their present configurations. PCK has 218,000 b/d of capacity with a mixture of western and East German technology.

78 FR 65639 - Notice of Filing; Wyrsch, Martha B.

Federal Register 2010, 2011, 2012, 2013, 2014

2013-11-01

... Filing; Wyrsch, Martha B. Take notice that on October 25, 2013, Martha B. Wyrsch submitted for filing, an application for authority to hold interlocking positions, pursuant to section 305(b) of the Federal Power Act (FPA), 16 U.S.C. 825d(b) and Part 45 of the Federal Energy Regulatory Commission's (Commission) Rules...

Modified Sierpenski Antenna With Metamaterial For Wireless Applications

NASA Astrophysics Data System (ADS)

Aggarwal, Ishita; Pandey, Sujata

2017-08-01

This paper presents a multiband antenna based on modified sierpenski fractal structure along with metamaterials for wireless applications. Multi bands are obtained at 2.1 GHz, 5.73 GHz, 7.6 GHz and 8.4 GHz with return losses -21.49 dB,-36.36 dB,-45dB, and -23.46 dBrespectively. The dimension of the substrate used for this antenna is 52 x 60 x 1.6 mm3 and dielectric constant is 4.4 with tanδ of 0.002. The peak gain of 6.6 dB, return loss of -45 dB and VSWR of 1 are obtained at 7.6 GHz. Metamaterial unit cells are loaded on ground to improve the antenna parameters. This is a simple and compact design and has multiband features suitable for WIMAX, WLAN, C-band and X-band applications. This design is simulated by using HFSS 14.

Water Processor and Oxygen Generation Assembly

NASA Technical Reports Server (NTRS)

Bedard, John

1997-01-01

This report documents the results of the tasks which initiated efforts on design issues relating to the Water Processor (WP) and the Oxygen Generation Assembly (OGA) Flight Hardware for the International Space Station. This report fulfills the Statement of Work deliverables requirement for contract H-29387D. The following lists the tasks required by contract H-29387D: (1) HSSSI shall coordinate a detailed review of WP/OGA Flight Hardware program requirements with personnel from MSFC to identify requirements that can be eliminated without affecting the technical integrity of the WP/OGA Hardware; (2) HSSSI shall conduct the technical interchanges with personnel from MSFC to resolve design issues related to WP/OGA Flight Hardware; (3) HSSSI will initiate discussions with Zellwegger Analytics, Inc. to address design issues related to WP and PCWQM interfaces.

Photothermal Deoxygenation of Graphene Oxide to Graphitic Carbon for Distributed Ignition and Patterning Applications (Preprint)

DTIC Science & Technology

2009-04-13

Brodie, B. Ann Chim. Phys. 1855, 45, 351 6. Dikin , D.; Stankovich, S.; Zimney, E. J.; Piner, R. D.; Dommett, H. B.; Evmenenko, G.; Nguyen, S. T...Stankovich, S.; Dikin , D. A.; Piner, R. D.; Kohlhaas, K. A.; Kleinhammes, A.; Jia, Y.; Wu, Y.; Nguyen, S. T.; Ruoff, R. S. Carbon 2007, 45(7), 1558...Gomez-Navarro, C.; Weitz, R. T.; Bittner, A. M.; Scolari, M.; Mews, A.; Burghrd. M.; Kern, K. Nano Lett. 2006, 7, 3499 16. Stankovich, S.; Dikin , D

General method for eliminating wave reflection in 2D photonic crystal waveguides by introducing extra scatterers based on interference cancellation of waves

NASA Astrophysics Data System (ADS)

Huang, Hao; Ouyang, Zhengbiao

2018-01-01

We propose a general method for eliminating the reflection of waves in 2 dimensional photonic crystal waveguides (2D-PCWs), a kind of 2D material, by introducing extra scatterers inside the 2D-PCWs. The intrinsic reflection in 2D-PCWs is compensated by the backward-scattered waves from these scatterers, so that the overall reflection is greatly reduced and the insertion loss is improved accordingly. We first present the basic theory for the compensation method. Then, as a demonstration, we give four examples of extremely-low-reflection and high-transmission 90°bent 2D-PCWs created according to the method proposed. In the four examples, it is demonstrated by plane-wave expansion method and finite-difference time-domain method that the 90°bent 2D-PCWs can have high transmission ratio greater than 90% in a wide range of operating frequency, and the highest transmission ratio can be greater than 99.95% with a return loss higher than 43 dB, better than that in other typical 90°bent 2D-PCWs. With our method, the bent 2D-PCWs can be optimized to obtain high transmission ratio at different operating wavelengths. As a further application of this method, a waveguide-based optical bridge for light crossing is presented, showing an optimum return loss of 46.85 dB, transmission ratio of 99.95%, and isolation rates greater than 41.77 dB. The method proposed provides also a useful way for improving conventional waveguides made of cables, fibers, or metal walls in the optical, infrared, terahertz, and microwave bands.

26 CFR 1.514(b)-1 - Definition of debt-financed property.

Code of Federal Regulations, 2013 CFR

2013-04-01

.... Example 2. X, an exempt college, owns a four story office building which has been purchased with borrowed funds. In 1971, the lower two stories of the building are used to house computers which are used by X... in section 514(b)(1) (A), (B), (C), or (D). The gross income derived by X from the building is $6,000...

26 CFR 1.514(b)-1 - Definition of debt-financed property.

Code of Federal Regulations, 2014 CFR

2014-04-01

.... Example 2. X, an exempt college, owns a four story office building which has been purchased with borrowed funds. In 1971, the lower two stories of the building are used to house computers which are used by X... in section 514(b)(1) (A), (B), (C), or (D). The gross income derived by X from the building is $6,000...

26 CFR 1.514(b)-1 - Definition of debt-financed property.

Code of Federal Regulations, 2011 CFR

2011-04-01

.... Example 2. X, an exempt college, owns a four story office building which has been purchased with borrowed funds. In 1971, the lower two stories of the building are used to house computers which are used by X... in section 514(b)(1) (A), (B), (C), or (D). The gross income derived by X from the building is $6,000...

26 CFR 1.514(b)-1 - Definition of debt-financed property.

Code of Federal Regulations, 2012 CFR

2012-04-01

.... Example 2. X, an exempt college, owns a four story office building which has been purchased with borrowed funds. In 1971, the lower two stories of the building are used to house computers which are used by X... in section 514(b)(1) (A), (B), (C), or (D). The gross income derived by X from the building is $6,000...

The National Shipbuilding Research Program. Application of Industrial Engineering Techniques to Reduce Worker’s Compensation and Environmental Costs - Deliverable A

DTIC Science & Technology

1999-10-01

N8-96-3 Application of Industrial Engineering Techniques to Reduce Workers ’ Compensation and Environmental Costs - Deliverable A U.S. DEPARTMENT OF...disclosed in the report. As used in the above, “Persons acting on behalf of the United States Navy” includes any employee , contractor, or subcontractor to...the contractor of the United States Navy to the extent that such employee , contractor, or subcontractor to the contractor prepares, handles, or

Glycine inhibits melanogenesis in vitro and causes hypopigmentation in vivo.

PubMed

Ishikawa, Masago; Kawase, Ichiro; Ishii, Fumio

2007-11-01

The simplest amino acid, glycine, is important in protein composition and plays a significant role in numerous physiological events in mammals. Despite the inhibitory effect of glycine on spontaneous melanogenesis in B16F0 melanoma cells, the details of the underlying mechanisms remain unknown. The present study was conducted to investigate the further effects and the mechanisms of inhibitory effect of glycine on melanogenesis using B16F0 melanoma cells and hair follicle melanogenesis in C57BL/6J mice. Treatment with glycine (1-16 mM) for 72 h inhibited alpha-melanocyte stimulating hormone (alpha-MSH)-induced melanogenesis in a concentration-dependent manner without any effects on cell proliferation in B16F0 melanoma cells. Treatment with kojic acid (2.5 mM) for 72 h also inhibited alpha-MSH-induced melanogenesis in B16F0 melanoma cells. The highest dose of glycine inhibited the alpha-MSH-induced increment of tyrosinase protein levels in B16F0 melanoma cells. In hair follicle melanogenesis in C57BL/6J mice, treatment with glycine (1250 or 2500 mg/kg, i.p.) for 5 d prevented the decrement of L* and C* values and inhibited the increment of tyrosinase protein levels and melanin content within the skin. Treatment with hydroquinone (100 mg/kg, i.p.) for 5 d had a similar hypopigmenting effect to that of high dose glycine. These results suggest that glycine has an inhibitory effect on melanogenesis that is mediated by down-regulation of tyrosinase protein levels, leading to a hypopigmenting effect in C57BL/6J mice.

Chain Dynamic Formulations for Multibody System Tracked Vehicles (Preprint)

DTIC Science & Technology

2013-03-06

Michael Wallin 1 Ahmed K. Aboubakr 1 Paramsothy Jayakumar 2 Michael D. Letherwood 2 Ashraf Hamed 1 Ahmed A. Shabana 1...5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) Michael Wallin; Ahmed Aboubakr; Paramsothy Jayakumar ; Michael Letherwood; Ashraf Hamed 5d...Taylor & Francis/CRC, Boca Raton, Florida. 16. Shabana, A. A., Hamed, A. M., Mohamed, A. A., Jayakumar , P., and Letherwood, M. D. 2012, “Use of B

Department of Defense Materiel Distribution System Study. Volume 3, Book 2. Appendices A, B and C

DTIC Science & Technology

1978-07-01

i . Oil .362 .00 382 13 971 13 .879,230 .00 1 .29b , 168 .00 38M 106 78b 61 . 719,799 .00 1,281 .136 .00 386 18...7 2 1302 Oil oJ7 b3V 1 73 bb2 b16 b 1 I bVU 803 127 bOO 612 326 16U V36 bbD 3b3 212 VI 1 2ib 0rt3 b6b 7V0 ObV 1 30 b7 1 82... luv 1 10 I I I 1 1 i 1 I J I I N 1 lb 1 1 6 1 I / 1 1 I ) 1 I "

A survey of music therapists' work with speech-language pathologists and experiences with augmentative and alternative communication.

PubMed

McCarthy, John; Geist, Kamile; Zojwala, Rashida; Schock, Molly Z

2008-01-01

Although music therapists may work with a variety of professionals in interdisciplinary teams, there is a lack of information about the specific nature of their work with speech-language pathologists (SLPs). Using an Internet-based tool, Board Certified Music Therapists (n = 1834, 1675 deliverable) were surveyed regarding their work with speech-language pathologists and experiences with augmentative and alternative communication (AAC). Specifically, participants were asked about: (a) demographics; (b) populations worked with professionally; (c) past and present work with speech-language pathologists; (d) goals addressed; (e) benefits and challenges encountered; and (f) work with AAC. Responses (N = 847) indicated the majority of participants (73.6%) had worked with SLPs at some point in various roles and in various settings. Fewer participants reported currently working with SLPs (42.8%), although 50.1% reported currently working with someone requiring some form of AAC. Participants reported a mean level of expertise with AAC of 3.9 on a scale of 1-7. Sharing knowledge was noted as a top benefit of working with SLPs, while scheduling was reported as the most frequent challenge. Other benefits and challenges as well as future research directions are discussed.

Firefighters' hearing: a comparison with population databases from the International Standards Organization.

PubMed

Kales, S N; Freyman, R L; Hill, J M; Polyhronopoulos, G N; Aldrich, J M; Christiani, D C

2001-07-01

We investigated firefighters' hearing relative to general population data to adjust for age-expected hearing loss. For five groups of male firefighters with increasing mean ages, we compared their hearing thresholds at the 50th and 90th percentiles with normative and age- and sex-matched hearing data from the International Standards Organization (databases A and B). At the 50th percentile, from a mean age of 28 to a mean age of 53 years, relative to databases A and B, the firefighters lost an excess of 19 to 23 dB, 20 to 23 dB, and 16 to 19 dB at 3000, 4000, and 6000 Hz, respectively. At the 90th percentile, from a mean age of 28 to a mean age of 53 years, relative to databases A and B, the firefighters lost an excess of 12 to 20 dB, 38 to 44 dB, 41 to 45 dB, and 22 to 28 dB at 2000, 3000, 4000, and 6000 Hz, respectively. The results are consistent with accelerated hearing loss in excess of age-expected loss among the firefighters, especially at or above the 90th percentile.

Air Force Cambridge Research Laboratories Report on Research, July 1972 - June 1974

DTIC Science & Technology

1975-05-01

Achievements of ALADDIN II DANDEKAR, B. S. 1973 Ann. Am. Geophys. Union Mtg., Wash., D. C. Determination of theAtomic Oxygen Concentration from the (16-20...Terrestrial Phys./I7th 1973 Ann. Am. Geophys. Union Mtg., Wash., D. C. Plenary Mtg. of COSPAR, Sao Paulo, Brazil (16-20 April 1973) (17June - I July 1974...Interplanetary Burlington, Mass.), HUFFMAN, R. E., and PAULSEN, Magnetic Field as Inferred from Polar Cap Observations D. E. 1973 Ann. Am. Geophys. Union

Linking 1D Transition-Metal Coordination Polymers and Different Inorganic Boron Oxides To Construct a Series of 3D Inorganic-Organic Hybrid Borates.

PubMed

Zhi, Shao-Chen; Wang, Yue-Lin; Sun, Li; Cheng, Jian-Wen; Yang, Guo-Yu

2018-02-05

Three inorganic-organic hybrid borates, M(1,4-dab)[B 5 O 7 (OH) 3 ] [M = Zn (1), Cd (2), 1,4-dab = 1,4-diaminobutane)] and Co(1,3-dap)[B 4 O 7 ] (3, 1,3-dap = 1,3-diaminopropane), which integrated characteristics of 1D coordination polymers and 1D/3D inorganic boron oxides have been obtained under solvothermal conditions. Compounds 1 and 2 are isostructural and crystallize in a centrosymmetric space group P2 1 /c; the 3D achiral structures of 1 and 2 consist of the nonhelical Zn/Cd-1,4-dap coordination polymers and 1D B-O chains. Compound 3 crystallizes in a chiral space group P4 3 2 1 2; the helical Co-1,3-dap coordination polymer chains are entrained within a 3D B-O network and finally form the chiral framework. Compounds 1-3 represent good examples of using coordination polymers to construct mixed-motif inorganic-organic hybrid borates. Compounds 1 and 2 display blue luminescence when excited with UV light.

Noise Levels in Patient Rooms and at Nursing Stations at Three VA Medical Centers.

PubMed

Hill, Jennifer N; LaVela, Sherri L

2015-01-01

To conduct an assessment of sound, dB(A) levels, in two areas of the hospital: patient rooms and nurse stations using sound meters (SMs). The World Health Organization (WHO) recommends sound levels of 35 dB(A) during the day and 30 dB(A) during the night; however, many hospitals exceed these recommended levels. Assessing post-occupancy sound levels enables hospital administrators and healthcare workers to identify whether interventions to improve sound levels are needed. Sound assessments were conducted at three healthcare facilities in both patient rooms and nursing stations, and we include information on facility characteristics. An Amprobe SM-20A Sound Level Meter was placed for a 24-hr period and recorded decibel levels every 8 min. These sound levels were averaged for each hour for reporting purposes. Averages as well as highest and lowest readings are reported for both daytime (8 a.m.-10 p.m.) and nighttime (10 p.m.-8 a.m.) for each facility. All three sites are considered urban and are classified with the highest complexity level (1a). Average daytime measurements for patient rooms and their corresponding nurses stations were as follows: Site A-63 dB(A)/56 dB(A), Site B-52 dB(A)/55 dB(A), and Site C-42 dB(A)/59 dB(A). Average nighttime measurements for patient rooms and nurses stations were Site A-62 dB(A)/55 dB(A), Site B-48 dB(A)/55 dB(A), and Site C-42 dB(A)/60 dB(A). Our findings, considered independently and collectively, showed that facilities in this study exceeded the WHO-recommended sound levels for patient rooms of 35 dB(A) during daytime and 30 dB(A) during nighttime. Research has reported negative patient outcomes, for example, decreased satisfaction, sleep disturbance, and higher incidence of rehospitalization in patients staying in areas with higher noise levels. © The Author(s) 2015.

Minor diterpene glycosides from the leaves of Stevia rebaudiana.

PubMed

Ibrahim, Mohamed A; Rodenburg, Douglas L; Alves, Kamilla; Fronczek, Frank R; McChesney, James D; Wu, Chongming; Nettles, Brian J; Venkataraman, Sylesh K; Jaksch, Frank

2014-05-23

Two new diterpene glycosides in addition to five known glycosides have been isolated from a commercial extract of the leaves of Stevia rebaudiana. Compound 1 (rebaudioside KA) was shown to be 13-[(O-β-d-glucopyranosyl)oxy]ent-kaur-16-en-19-oic acid 2-O-β-d-glucopyranosyl-β-d-glucopyranosyl ester and compound 2, 12-α-[(2-O-β-d-glucopyranosyl-β-d-glucopyranosyl)oxy]ent-kaur-16-en-19-oic acid β-d-glucopyranosyl ester. Five additional known compounds were identified, rebaudioside E, rebaudioside M, rebaudioside N, rebaudioside O, and stevioside, respectively. Enzymatic hydrolysis of stevioside afforded the known ent-kaurane aglycone 13-hydroxy-ent-kaur-16-en-19-oic acid (steviol) (3). The isolated metabolite 1 possesses the ent-kaurane aglycone steviol (3), while compound 2 represents the first example of the isomeric diterpene 12-α-hydroxy-ent-kaur-16-en-19-oic acid existing as a glycoside in S. rebaudiana. The structures of the isolated metabolites 1 and 2 were determined based on comprehensive 1D- and 2D-NMR (COSY, HSQC, and HMBC) studies. A high-quality crystal of compound 3 has formed, which allowed the acquisition of X-ray diffraction data that confirmed its structure. The structural similarities between the new metabolites and the commercially available stevioside sweeteners suggest the newly isolated metabolites should be examined for their organoleptic properties. Accordingly rebaudiosides E, M, N, O, and KA have been isolated in greater than gram quantities.

Power Amplifier Linearizer for High Frequency Medical Ultrasound Applications

PubMed Central

Choi, Hojong; Jung, Hayong; Shung, K. Kirk

2015-01-01

Power amplifiers (PAs) are used to produce high-voltage excitation signals to drive ultrasonic transducers. A larger dynamic range of linear PAs allows higher contrast resolution, a highly desirable characteristic in ultrasonic imaging. The linearity of PAs can be improved by reducing the nonlinear harmonic distortion components of high-voltage output signals. In this paper, a linearizer circuit is proposed to reduce output signal harmonics when working in conjunction with a PA. The PA performance with and without the linearizer was measured by comparing the output power 1-dB compression point (OP1dB), and the second- and third-order harmonic distortions (HD2 and HD3, respectively). The results show that the PA with the linearizer circuit had higher OP1dB (31.7 dB) and lower HD2 (−61.0 dB) and HD3 (−42.7 dB) compared to those of the PA alone (OP1dB (27.1 dB), HD2 (−38.2 dB), and HD3 (−36.8 dB)) at 140 MHz. A pulse-echo measurement was also performed to further evaluate the capability of the linearizer circuit. The HD2 of the echo signal received by the transducer using a PA with the linearizer (−24.8 dB) was lower than that obtained for the PA alone (−16.6 dB). The linearizer circuit is capable of improving the linearity performance of PA by lowering harmonic distortions. PMID:26622209

31 CFR 315.16 - Pledge.

Code of Federal Regulations, 2010 CFR

2010-07-01

... OF THE TREASURY BUREAU OF THE PUBLIC DEBT REGULATIONS GOVERNING U.S. SAVINGS BONDS, SERIES A, B, C, D, E, F, G, H, J, AND K, AND U.S. SAVINGS NOTES Limitations on Transfer or Pledge § 315.16 Pledge. (a...

Load Composition Model Workflow (BPA TIP-371 Deliverable 1A)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chassin, David P.; Cezar, Gustavo V.

This project is funded under Bonneville Power Administration (BPA) Strategic Partnership Project (SPP) 17-005 between BPA and SLAC National Accelerator Laboratory. The project in a BPA Technology Improvement Project (TIP) that builds on and validates the Composite Load Model developed by the Western Electric Coordinating Council's (WECC) Load Modeling Task Force (LMTF). The composite load model is used by the WECC Modeling and Validation Work Group to study the stability and security of the western electricity interconnection. The work includes development of load composition data sets, collection of load disturbance data, and model development and validation. This work supports reliablemore » and economic operation of the power system. This report was produced for Deliverable 1A of the BPA TIP-371 Project entitled \\TIP 371: Advancing the Load Composition Model". The deliverable documents the proposed work ow for the Composite Load Model, which provides the basis for the instrumentation, data acquisition, analysis and data dissemination activities addressed by later phases of the project.« less

Analysis of Performance of Selected AFC, ATF Fuels, and Lanthanide Transport

DOE Office of Scientific and Technical Information (OSTI.GOV)

Unal, Cetin; Galloway, Jack D.

2015-09-29

We started to look at the performance of ATF concept in LWRs late in FY14 and finish our studies in FY15. The work has been presented in AFC review meetings, ICAPP and TOPFUEL conferences. The final version of the work is accepted for publication in Nuclear Engineering and Science Journal (NES). The copy of ICAPP and NES papers are attached separately to this document as our milestone deliverables. We made an important progress in the modeling of lanthanide transport in FY15. This work produced an ANS Winter Meeting paper and GLOBAL 2015 paper. GLOBAL 2015 paper is also attached asmore » deliverable of FY15. The work on the lanthanide transport is preliminary. We are exploring other potential mechanisms, in addition to “liquid-like” diffusion mechanisms, proposed by Robert Mariani [1] before we analyze data that will be taken by Ohio State University. This year, we concentrate on developing diffusion kernels and principles of modeling. Next year, this work will continue and analyze the Ohio State data and develop approaches to solve multicomponent diffusion. In addition to three papers we attached to this report, we have done some research on coupling and the development of gas release model for metallic fuels in FY15. They are also preliminary in nature; therefore, we give the summary of what we found rather than an extended report that will be done in FY16.« less

The influence of continuous and intermittent traffic noise on sleep

NASA Astrophysics Data System (ADS)

Eberhardt, J. L.; Stråle, L.-O.; Berlin, M. H.

1987-08-01

The effects of road traffic noise on sleep were studied in the laboratory using nine young male adults (aged 20-26). The subjects were exposed to noise with different temporal characteristics: (i) continuous traffic noise of 36 dB(A) or 45 dB(A), (ii) intermittent noise of 50 truck passages with L pmax = 45 dB(A) ( L eq = 29 dB(A)) or L pmax = 55 dB(A) ( L eq = 36 dB(A)), and (iii) a combination of continuous (45 dB(A)) and intermittent ( L pmax = 55 dB(A)) traffic noise. For one noise condition (intermittent 55 dB(A)) the effect of the use of ear plugs was also studied. The intermittent noise of L pmax = 45 dB(A) caused transitions towards lighter sleep, whereas 55 dB(A) was needed to induce awakening effects. It could be shown that the probability for arousal reactions depends on the emergence of the noise peaks from the background, rather than the absolute noise peak level. Continuous traffic noise of 45 dB(A) caused REM sleep deficits, while intermittent traffic noise of L pmax = 45 dB(A) caused stage III+IV deficits. The night with ear plugs was virtually undisturbed. After nights with REM sleep deficits the subjective sleep quality was rated lower and mood was influenced adversely. For the types of exposure used in the present investigation L eq alone is not an adequate descriptor of the noise dose, relating to the sleep disturbances observed. From the present experiment, together with other existing data, it might be concluded that the WHO recommendation of L eq = 35 dB(A) is adequate, but should be supplemented with a maximum noise level, as expressed for example in L pmax or LI, that should not be exceeded.

Large scale mitochondrial sequencing in Mexican Americans suggests a reappraisal of Native American origins.

PubMed

Kumar, Satish; Bellis, Claire; Zlojutro, Mark; Melton, Phillip E; Blangero, John; Curran, Joanne E

2011-10-07

The Asian origin of Native Americans is largely accepted. However uncertainties persist regarding the source population(s) within Asia, the divergence and arrival time(s) of the founder groups, the number of expansion events, and migration routes into the New World. mtDNA data, presented over the past two decades, have been used to suggest a single-migration model for which the Beringian land mass plays an important role. In our analysis of 568 mitochondrial genomes, the coalescent age estimates of shared roots between Native American and Siberian-Asian lineages, calculated using two different mutation rates, are A4 (27.5 ± 6.8 kya/22.7 ± 7.4 kya), C1 (21.4 ± 2.7 kya/16.4 ± 1.5 kya), C4 (21.0 ± 4.6 kya/20.0 ± 6.4 kya), and D4e1 (24.1 ± 9.0 kya/17.9 ± 10.0 kya). The coalescent age estimates of pan-American haplogroups calculated using the same two mutation rates (A2:19.5 ± 1.3 kya/16.1 ± 1.5 kya, B2:20.8 ± 2.0 kya/18.1 ± 2.4 kya, C1:21.4 ± 2.7 kya/16.4 ± 1.5 kya and D1:17.2 ± 2.0 kya/14.9 ± 2.2 kya) and estimates of population expansions within America (~21-16 kya), support the pre-Clovis occupation of the New World. The phylogeography of sublineages within American haplogroups A2, B2, D1 and the C1b, C1c and C1d subhaplogroups of C1 are complex and largely specific to geographical North, Central and South America. However some sub-branches (B2b, C1b, C1c, C1d and D1f) already existed in American founder haplogroups before expansion into the America. Our results suggest that Native American founders diverged from their Siberian-Asian progenitors sometime during the last glacial maximum (LGM) and expanded into America soon after the LGM peak (~20-16 kya). The phylogeography of haplogroup C1 suggest that this American founder haplogroup differentiated in Siberia-Asia. The situation is less clear for haplogroup B2, however haplogroups A2 and D1 may have differentiated soon after the Native American founders divergence. A moderate population bottle neck in American founder populations just before the expansion most plausibly resulted in few founder types in America. The similar estimates of the diversity indices and Bayesian skyline analysis in North America, Central America and South America suggest almost simultaneous (~ 2.0 ky from South to North America) colonization of these geographical regions with rapid population expansion differentiating into more or less regional branches across the pan-American haplogroups.

Large scale mitochondrial sequencing in Mexican Americans suggests a reappraisal of Native American origins

PubMed Central

2011-01-01

Background The Asian origin of Native Americans is largely accepted. However uncertainties persist regarding the source population(s) within Asia, the divergence and arrival time(s) of the founder groups, the number of expansion events, and migration routes into the New World. mtDNA data, presented over the past two decades, have been used to suggest a single-migration model for which the Beringian land mass plays an important role. Results In our analysis of 568 mitochondrial genomes, the coalescent age estimates of shared roots between Native American and Siberian-Asian lineages, calculated using two different mutation rates, are A4 (27.5 ± 6.8 kya/22.7 ± 7.4 kya), C1 (21.4 ± 2.7 kya/16.4 ± 1.5 kya), C4 (21.0 ± 4.6 kya/20.0 ± 6.4 kya), and D4e1 (24.1 ± 9.0 kya/17.9 ± 10.0 kya). The coalescent age estimates of pan-American haplogroups calculated using the same two mutation rates (A2:19.5 ± 1.3 kya/16.1 ± 1.5 kya, B2:20.8 ± 2.0 kya/18.1 ± 2.4 kya, C1:21.4 ± 2.7 kya/16.4 ± 1.5 kya and D1:17.2 ± 2.0 kya/14.9 ± 2.2 kya) and estimates of population expansions within America (~21-16 kya), support the pre-Clovis occupation of the New World. The phylogeography of sublineages within American haplogroups A2, B2, D1 and the C1b, C1c andC1d subhaplogroups of C1 are complex and largely specific to geographical North, Central and South America. However some sub-branches (B2b, C1b, C1c, C1d and D1f) already existed in American founder haplogroups before expansion into the America. Conclusions Our results suggest that Native American founders diverged from their Siberian-Asian progenitors sometime during the last glacial maximum (LGM) and expanded into America soon after the LGM peak (~20-16 kya). The phylogeography of haplogroup C1 suggest that this American founder haplogroup differentiated in Siberia-Asia. The situation is less clear for haplogroup B2, however haplogroups A2 and D1 may have differentiated soon after the Native American founders divergence. A moderate population bottle neck in American founder populations just before the expansion most plausibly resulted in few founder types in America. The similar estimates of the diversity indices and Bayesian skyline analysis in North America, Central America and South America suggest almost simultaneous (~ 2.0 ky from South to North America) colonization of these geographical regions with rapid population expansion differentiating into more or less regional branches across the pan-American haplogroups. PMID:21978175

[Effect of acoustic stimulus intensity on air-conducted sound elicited ocular vestibular-evoked myogenic potential and cervical vestibular-evoked myogenic potential].

PubMed

Zhang, Rui; Xu, Min; Zhang, Qing; Yang, Yin-Tong; Chen, Yanfei

2014-06-01

To observe the effect of acoustic stimulus intensity on air-conducted sound elicited ocular vestibular- evoked myogenic potential (oVEMP) and cervical vestibular-evoked myogenic potential (cVEMP) in normal young Chinese subjects. Thirty-five normal subjects aged 4-40 years (20.80∓8.89 years), including 16 males and 19 females, were recruited for conventional oVEMP and cVEMP examinations. The responses obtained from each side using 500 Hz tone bursts were divided into 6 groups according to different sound intensities (100, 95, 90, 85, 80 and 75dB nHL). The response rate and normal parameters of each stimulus intensity group were calculated. As the acoustic stimulus intensity decreased, the oVEMP response rate decreased from 100% in both 100 dB nHL and 95dB nHL groups to 97.14% (90 dB nHL), 54.29% (85 dB nHL), 14.29% (80 dB nHL), and 2.86% (75 dB nHL), and the response rate of cVEMP, 100% in both 100 dB nHL and 95dB nHL groups, was lowered to 97.14% (90 dB nHL), 84.29% (85 dB nHL), 38.57% (80 dB nHL) and 8.57% (75 dB nHL). The response rate and the parameters were comparable between 100 and 95 dB nHL groups. As the acoustic stimulus intensity decreases, both oVEMP and cVEMP show decreased response rate and amplitude. For Chinese subjects under 40 years of age, we recommend 95dB nHL as the maximum initial stimulus intensity in VEMPs test.

Effects of Multimodal Displays About Threat Location on Target Acquisition and Attention to Visual and Auditory Communications

DTIC Science & Technology

2007-04-01

and Space Administration ( NASA ) Task Load Index ( TLX ...Report (SITREP) Example 33 Appendix B. SITREP Questionnaire Example 35 Appendix C. NASA - TLX 37 Appendix D. Demographic Questionnaire 41...Load Index ( TLX ) The NASA - TLX was used to assess the participant’s experience of workload (Hart & Staveland, 1988). This technique uses rating

Search for B to K nu nubar decays with a semileptonic tag

NASA Astrophysics Data System (ADS)

Vuosalo, Carl

Flavor-changing neutral-current transitions such as b → snunu are absent at tree level in the Standard Model and can only occur via loop diagrams. Several new physics models may enhance the rate of these transitions. This document presents searches for the exclusive decays B+u → K+nunu and B0d → K0S nunu, which have a predicted theoretical branching fraction of ( 3.8+1.2-0.6 ) x 10-6. The presence of two neutrinos in the final state makes recognition of the signal challenging, so the full reconstruction of one B meson in the semileptonic decay channel B → D(*) lnu is used to facilitate the search for the signal in the recoiling B. This analysis uses approximately 420 fb-1 or 460 million BB¯ pairs collected over runs 1-6 with the BABAR detector at the PEP-II B factory. This analysis finds 90% confidence level upper limits on the branching fractions of 1.3 x 10-5 for B+u → K+nunu, 5.6 x 10-5 for B0d → K0nunu, and the first upper limits on the partial branching fractions for B+u → K+nunu of 3.1 x 10-5 for K+ CMS momentum < 1.5 GeV/c and of 0.89 x 10-5 for K+ CMS momentum > 1.5 GeV/c. These results improve upon the previous best upper limits, which came from the Belle experiment, of 1.4 x 10-5 for B+u → K+nunu and 16 x 10-5 for B0d → K0nunu. They also rule out a new physics model of scalar dark matter for scalar particle masses below 1.7 GeV/c2.

MO-FG-BRA-08: Swarm Intelligence-Based Personalized Respiratory Gating in Lung SAbR

DOE Office of Scientific and Technical Information (OSTI.GOV)

Modiri, A; Sabouri, P; Sawant, A

Purpose: Respiratory gating is widely deployed as a clinical motion-management strategy in lung radiotherapy. In conventional gating, the beam is turned on during a pre-determined phase window; typically, around end-exhalation. In this work, we challenge the notion that end-exhalation is always the optimal gating phase. Specifically, we use a swarm-intelligence-based, inverse planning approach to determine the optimal respiratory phase and MU for each beam with respect to (i) the state of the anatomy at each phase and (ii) the time spent in that state, estimated from long-term monitoring of the patient’s breathing motion. Methods: In a retrospective study of fivemore » lung cancer patients, we compared the dosimetric performance of our proposed personalized gating (PG) with that of conventional end-of-exhale gating (CEG) and a previously-developed, fully 4D-optimized plan (combined with MLC tracking delivery). For each patient, respiratory phase probabilities (indicative of the time duration of the phase) were estimated over 2 minutes from lung tumor motion traces recorded previously using the Synchrony system (Accuray Inc.). Based on this information, inverse planning optimization was performed to calculate the optimal respiratory gating phase and MU for each beam. To ensure practical deliverability, each PG beam was constrained to deliver the assigned MU over a time duration comparable to that of CEG delivery. Results: Maximum OAR sparing for the five patients achieved by the PG and the 4D plans compared to CEG plans was: Esophagus Dmax [PG:57%, 4D:37%], Heart Dmax [PG:71%, 4D:87%], Spinal cord Dmax [PG:18%, 4D:68%] and Lung V13 [PG:16%, 4D:31%]. While patients spent the most time in exhalation, the PG-optimization chose end-exhale only for 28% of beams. Conclusion: Our novel gating strategy achieved significant dosimetric improvements over conventional gating, and approached the upper limit represented by fully 4D optimized planning while being significantly simpler and more clinically translatable. This work was partially supported through research funding from National Institutes of Health (R01CA169102) and Varian Medical Systems, Palo Alto, CA, USA.« less

Coherently wavelength injection-locking a 600-μm long cavity colorless laser diode for 16-QAM OFDM at 12 Gbit/s over 25-km SMF.

PubMed

Li, Yi-Cheng; Chi, Yu-Chieh; Cheng, Min-Chi; Lu, I-Cheng; Chen, Jason; Lin, Gong-Ru

2013-07-15

The coherent injection-locking and directly modulation of a long-cavity colorless laser diode with 1% end-facet reflectance and weak-resonant longitudinal modes is employed as an universal optical transmitter to demonstrated for optical 16-QAM OFDM transmission at 12 Gbit/s over 25 km in a DWDM-PON system. The optimized bias current of 30 mA (~1.5Ith) with corresponding extinction ratio (ER) of 6 dB and the external injection power of -9 dBm is (are) required for such a wavelength-locked universal transmitter to carry the 16-QAM and 122-subcarrier formatted OFDM and data-stream. By increasing external injection-locking from -9 dBm to 0 dBm, the peak-to-peak chirp of the OFDM data stream reduces from 7.7 to 5.4 GHz. The side mode suppression ratio (SMSR) of up to 50 dB is achieved with wider detuning range between -0.5 nm to 2.0 nm under an injection power of 0 dBm. By modulating such a colorless laser diode with an OFDM data stream of 122 subcarriers at a central carrier frequency of 1.5625 GHz and a total bandwidth of 3 GHz, the transmission data rate of up to 12 Gbit/s in standard single-mode fiber over 25 km is demonstrated to achieve an error vector magnitude (EVM) of 5.435%. Such a universal colorless DWDM-PON transmitter can deliver the optical OFDM data-stream at 12 Gbit/s QAM-OFDM data after 25-km transmission with a receiving power sensitivity of -7 dBm at BER of 3.6 × 10(-7) when pre-amplifying the OFDM data by 5 dB.

Measurements of the branching fractions for B{sub (s)}{yields}D{sub (s)}{pi}{pi}{pi} and {Lambda}{sub b}{sup 0}{yields}{Lambda}{sub c}{sup +}{pi}{pi}{pi}

DOE Office of Scientific and Technical Information (OSTI.GOV)

Aaij, R.; Bauer, Th.; Beuzekom, M. van

Branching fractions of the decays H{sub b}{yields}H{sub c}{pi}{sup -}{pi}{sup +}{pi}{sup -} relative to H{sub b}{yields}H{sub c}{pi}{sup -} are presented, where H{sub b} (H{sub c}) represents B{sup 0} (D{sup +}), B{sup -} (D{sup 0}), B{sub s}{sup 0} (D{sub s}{sup +}), and {Lambda}{sub b}{sup 0} ({Lambda}{sub c}{sup +}). The measurements are performed with the LHCb detector using 35 pb{sup -1} of data collected at {radical}(s)=7 TeV. The ratios of branching fractions are measured to be [B(B{sup 0}{yields}D{sup +}{pi}{sup -}{pi}{sup +}{pi}{sup -})]/[B(B{sup 0}{yields}D{sup +}{pi}{sup -})]=2.38{+-}0.11{+-}0.21, [B(B{sup -}{yields}D{sup 0}{pi}{sup -}{pi}{sup +}{pi}{sup -})]/[B(B{sup -}{yields}D{sup 0}{pi}{sup -})]= 1.27{+-}0.06{+-}0.11, [B(B{sub s}{sup 0}{yields}D{sub s}{sup +}{pi}{sup -}{pi}{sup +}{pi}{sup -})]/[B(B{submore » s}{sup 0}{yields}D{sub s}{sup +}{pi}{sup -})]=2.01{+-}0.37{+-}0.20, [B({Lambda}{sub b}{sup 0}{yields}{Lambda}{sub c}{sup +}{pi}{sup -} {pi}{sup +}{pi}{sup -})]/[B({Lambda}{sub b}{sup 0}{yields}{Lambda}{sub c}{sup +}{pi}{sup -})]=1.43{+-}0.16{+-}0.13 We also report measurements of partial decay rates of these decays to excited charm hadrons. These results are of comparable or higher precision than existing measurements.« less

16 CFR 1115.4 - Defect.

Code of Federal Regulations, 2010 CFR

2010-01-01

... error. (b) Shoes labeled and marketed for long-distance running are so designed that they might cause or contribute to the causing of muscle or tendon injury if used for long-distance running. The shoes are... example, a knife has a sharp blade and is capable of seriously injuring someone. This very sharpness, how...

16 CFR 1115.4 - Defect.

Code of Federal Regulations, 2014 CFR

2014-01-01

... error. (b) Shoes labeled and marketed for long-distance running are so designed that they might cause or contribute to the causing of muscle or tendon injury if used for long-distance running. The shoes are... example, a knife has a sharp blade and is capable of seriously injuring someone. This very sharpness, how...

16 CFR 1115.4 - Defect.

Code of Federal Regulations, 2012 CFR

2012-01-01

... error. (b) Shoes labeled and marketed for long-distance running are so designed that they might cause or contribute to the causing of muscle or tendon injury if used for long-distance running. The shoes are... example, a knife has a sharp blade and is capable of seriously injuring someone. This very sharpness, how...

16 CFR 1115.4 - Defect.

Code of Federal Regulations, 2011 CFR

2011-01-01

... error. (b) Shoes labeled and marketed for long-distance running are so designed that they might cause or contribute to the causing of muscle or tendon injury if used for long-distance running. The shoes are... example, a knife has a sharp blade and is capable of seriously injuring someone. This very sharpness, how...

16 CFR Appendix B to Part 313 - Sample Clauses

Code of Federal Regulations, 2010 CFR

2010-01-01

..., such as [provide illustrative examples, such as “your name, address, social security number, assets... about you to nonaffiliated third parties as permitted by law. A-5—Service Provider/Joint Marketing..., Alternative 1 We may disclose the following information to companies that perform marketing services on our...

16 CFR 700.5 - Expressions of general policy.

Code of Federal Regulations, 2010 CFR

2010-01-01

... an exemption under section 103(b) such policies may not be subject to any specific limitations. For example, policies which have an express limitation of duration or a limitation of the amount to be... concerning customer satisfaction which are not subject to any specific limitation need not be designated as...

26 CFR 1.883-0 - Outline of major topics.

Code of Federal Regulations, 2010 CFR

2010-04-01

...) Primarily traded. (d) Regularly traded. (1) General rule. (2) Classes of stock traded on a domestic.... (A) Related persons. (B) Investment companies. (4) Anti-abuse rule. (5) Example. (e) Substantiation...

Simultaneous measurements of L- and S-band tree shadowing for space-Earth communications

NASA Technical Reports Server (NTRS)

Vogel, Wolfhard J.; Torrence, Geoffrey W.; Lin, Hsin P.

1995-01-01

We present results from simultaneous L- and S-Band slant-path fade measurements through trees. One circularly-polarized antenna was used at each end of the dual-frequency link to provide information on the correlation of tree shadowing at 1620 and 2500 MHz. Fades were measured laterally in the shadow region with 5 cm spacing. Fade differences between L- and S-Band had a normal distribution with low means and standard deviations from 5.2 to 7.5 dB. Spatial variations occurred with periods larger than 1-2 wavelengths. Swept measurements over 160 MHz spans showed that the stdv. of power as function of frequency increased from approximately 1-6 dB at locations with mean fades of 4 and 20 dB, respectively. At a 5 dB fade, the central 90% of fade slopes were within a range of 0.7 (1.9) dB/MHz at L-(S-) Band.

Update 2016: Considerations for Using Agile in DoD Acquisition

DTIC Science & Technology

2016-12-01

What Is Agile? 4 2.1 Agile Manifesto and Principles—A Brief History 4 2.2 A Practical Definition 6 2.3 Example Agile Method 6 2.4 Example Agile...5.8 Team Composition 45 5.9 Culture 46 6 Conclusion 48 Appendix A: Examples of Agile Methods 50 Appendix B: Common Objections to Agile 53...thank all those who have contributed to our knowledge of apply- ing “other than traditional” methods for software system acquisition and management over

Global Distribution and Evolutionary History of Enterovirus D68, with Emphasis on the 2014 Outbreak in Ontario, Canada.

PubMed

Eshaghi, Alireza; Duvvuri, Venkata R; Isabel, Sandra; Banh, Philip; Li, Aimin; Peci, Adriana; Patel, Samir N; Gubbay, Jonathan B

2017-01-01

Despite its first appearance in 1962, human enterovirus D68 (EV-D68) has been recognized as an emerging respiratory pathogen in the last decade when it caused outbreaks and clusters in several countries including Japan, the Philippines, and the Netherlands. The most recent and largest outbreak of EV-D68 associated with severe respiratory illness took place in North America between August 2014 and January 2015. Between September 1 and October 31 2014, EV-D68 infection was laboratory confirmed among 153/907 (16.9%) persons tested for the virus in Ontario, Canada, using real time RT-PCR and subsequent genotyping by sequencing of partial VP1 gene. In order to understand the evolutionary history of the 2014 North American EV-D68 outbreak, we conducted phylogenetic and phylodynamic analyses using available partial VP1 genes ( n = 469) and NCBI available whole genome sequences (WGS) ( n = 38). The global EV-D68 phylogenetic tree ( n = 469) reconfirms the divergence of three distinct clades A, B, and C from the prototype EV-D68 Fermon strain as previously documented. Two sub-clades (B1 and B2) were identified, with most 2014 EV-D68 outbreak strains belonging to sub-cluster B2b2 (one of the two emerging clusters within sub-clade B2), with two signature substitutions T650A and M700V in BC and DE loops of VP1 gene, respectively. The close homology between WGS of strains from Ontario ( n = 2) and USA ( n = 21) in the recent EV-D68 outbreak suggests genetic relatedness and also a common source for the outbreak. The time of most recent common ancestor of EV-D68 and the 2014 EV-D68 outbreak strain suggest that the viruses possibly emerged during 1960-1961 and 2012-2013, respectively. We observed lower mean evolutionary rates of global EV-D68 using WGS data than estimated with partial VP1 gene sequences. Based on WGS data, the estimated mean rate of evolution of the EV-D68 B2b cluster was 9.75 × 10 -3 substitutions/site/year (95% BCI 4.11 × 10 -3 to 16 × 10 -3 ).

Global Distribution and Evolutionary History of Enterovirus D68, with Emphasis on the 2014 Outbreak in Ontario, Canada

PubMed Central

Eshaghi, Alireza; Duvvuri, Venkata R.; Isabel, Sandra; Banh, Philip; Li, Aimin; Peci, Adriana; Patel, Samir N.; Gubbay, Jonathan B.

2017-01-01

Despite its first appearance in 1962, human enterovirus D68 (EV-D68) has been recognized as an emerging respiratory pathogen in the last decade when it caused outbreaks and clusters in several countries including Japan, the Philippines, and the Netherlands. The most recent and largest outbreak of EV-D68 associated with severe respiratory illness took place in North America between August 2014 and January 2015. Between September 1 and October 31 2014, EV-D68 infection was laboratory confirmed among 153/907 (16.9%) persons tested for the virus in Ontario, Canada, using real time RT-PCR and subsequent genotyping by sequencing of partial VP1 gene. In order to understand the evolutionary history of the 2014 North American EV-D68 outbreak, we conducted phylogenetic and phylodynamic analyses using available partial VP1 genes (n = 469) and NCBI available whole genome sequences (WGS) (n = 38). The global EV-D68 phylogenetic tree (n = 469) reconfirms the divergence of three distinct clades A, B, and C from the prototype EV-D68 Fermon strain as previously documented. Two sub-clades (B1 and B2) were identified, with most 2014 EV-D68 outbreak strains belonging to sub-cluster B2b2 (one of the two emerging clusters within sub-clade B2), with two signature substitutions T650A and M700V in BC and DE loops of VP1 gene, respectively. The close homology between WGS of strains from Ontario (n = 2) and USA (n = 21) in the recent EV-D68 outbreak suggests genetic relatedness and also a common source for the outbreak. The time of most recent common ancestor of EV-D68 and the 2014 EV-D68 outbreak strain suggest that the viruses possibly emerged during 1960–1961 and 2012–2013, respectively. We observed lower mean evolutionary rates of global EV-D68 using WGS data than estimated with partial VP1 gene sequences. Based on WGS data, the estimated mean rate of evolution of the EV-D68 B2b cluster was 9.75 × 10-3 substitutions/site/year (95% BCI 4.11 × 10-3 to 16 × 10-3). PMID:28298902

Hints for new sources of flavour violation in meson mixing

NASA Astrophysics Data System (ADS)

Blanke, M.

2017-07-01

The recent results by the Fermilab-Lattice and MILC collaborations on the hadronic matrix elements entering B_{d,s} - bar{B}_{d,s} mixing show a significant tension of the measured values of the mass differences Δ M_{d,s} with their SM predictions. We review the implications of these results in the context of Constrained Minimal Flavour Violation models. In these models, the CKM elements γ and \\vert V_{ub}\\vert/\\vert V_{cb}\\vert can be determined from B_{d,s} - bar{B}_{d,s} mixing observables, yielding a prediction for γ below its tree-level value. Determining subsequently \\vert V_{cb}\\vert from the measured value of either Δ M_s or ɛ_K gives inconsistent results, with the tension being smallest in the Standard Model limit. This tension can be resolved if the flavour universality of new contributions to Δ F = 2 observables is broken. We briefly discuss the case of U(2)^3 flavour models as an illustrative example.

B-branes and supersymmetric quivers in 2d

NASA Astrophysics Data System (ADS)

Closset, Cyril; Guo, Jirui; Sharpe, Eric

2018-02-01

We study 2d N = (0, 2) supersymmetric quiver gauge theories that describe the low-energy dynamics of D1-branes at Calabi-Yau fourfold (CY4) singularities. On general grounds, the holomorphic sector of these theories — matter content and (classical) superpotential interactions — should be fully captured by the topological B-model on the CY4. By studying a number of examples, we confirm this expectation and flesh out the dictionary between B-brane category and supersymmetric quiver: the matter content of the supersymmetric quiver is encoded in morphisms between B-branes (that is, Ext groups of coherent sheaves), while the superpotential interactions are encoded in the A ∞ algebra satisfied by the morphisms. This provides us with a derivation of the supersymmetric quiver directly from the CY4 geometry. We also suggest a relation between triality of N = (0 ,2) gauge theories and certain mutations of exceptional collections of sheaves. 0d N = 1 supersymmetric quivers, corresponding to D-instantons probing CY5 singularities, can be discussed similarly.

Principles of Discrete Time Mechanics

NASA Astrophysics Data System (ADS)

Jaroszkiewicz, George

2014-04-01

1. Introduction; 2. The physics of discreteness; 3. The road to calculus; 4. Temporal discretization; 5. Discrete time dynamics architecture; 6. Some models; 7. Classical cellular automata; 8. The action sum; 9. Worked examples; 10. Lee's approach to discrete time mechanics; 11. Elliptic billiards; 12. The construction of system functions; 13. The classical discrete time oscillator; 14. Type 2 temporal discretization; 15. Intermission; 16. Discrete time quantum mechanics; 17. The quantized discrete time oscillator; 18. Path integrals; 19. Quantum encoding; 20. Discrete time classical field equations; 21. The discrete time Schrodinger equation; 22. The discrete time Klein-Gordon equation; 23. The discrete time Dirac equation; 24. Discrete time Maxwell's equations; 25. The discrete time Skyrme model; 26. Discrete time quantum field theory; 27. Interacting discrete time scalar fields; 28. Space, time and gravitation; 29. Causality and observation; 30. Concluding remarks; Appendix A. Coherent states; Appendix B. The time-dependent oscillator; Appendix C. Quaternions; Appendix D. Quantum registers; References; Index.

Water deficit during pit hardening enhances phytoprostanes content, a plant biomarker of oxidative stress, in extra virgin olive oil.

PubMed

Collado-González, Jacinta; Pérez-López, David; Memmi, Houssem; Gijón, M Carmen; Medina, Sonia; Durand, Thierry; Guy, Alexandre; Galano, Jean-Marie; Ferreres, Federico; Torrecillas, Arturo; Gil-Izquierdo, Angel

2015-04-15

No previous information exists on the effects of water deficit on the phytoprostanes (PhytoPs) content in extra virgin olive oil from fruits of mature olive (Olea europaea L. cv. Cornicabra) trees during pit hardening. PhytoPs profile in extra virgin olive oil was characterized by the presence of 9-F1t-PhytoP, 9-epi-9-F1t-PhytoP, 9-epi-9-D1t-PhytoP, 9-D1t-PhytoP, 16-B1-PhytoP + ent-16-B1-PhytoP, and 9-L1-PhytoP + ent-9-L1-PhytoP. The qualitative and quantitative differences in PhytoPs content with respect to those reported by other authors indicate a decisive effect of cultivar, oil extraction technology, and/or storage conditions prone to autoxidation. The pit hardening period was critical for extra virgin olive oil composition because water deficit enhanced the PhytoPs content, with the concomitant potential beneficial aspects on human health. From a physiological and agronomical point of view, 9-F1t-PhytoP, 9-epi-9-F1t-PhytoP, and 16-B1-PhytoP + ent-16-B1-PhytoP could be considered as early candidate biomarkers of water stress in olive tree.

A 205GHz Amplifier in 90nm CMOS Technology

DTIC Science & Technology

2017-03-01

San Jose State University San Jose, CA, USA       Abstract: This paper presents a 205GHz amplifier drawing 43.4mA from a 0.9V power supply with...10.5dB power gain, Psat of -1.6dBm, and P1dB ≈ -5.8dBm in a standard 90nm CMOS process. Moreover, the design employs internal (layout-based) /external...reported in [2]. In this paper, two neutralization techniques, internal and external approaches, have been implemented to achieve higher power

Experimental Demonstration of a Photonic-Crystal-Fiber Optical Diode

DTIC Science & Technology

2004-01-01

M. Scalora , A.M. Zheltikov: Appl. Opt. 43, 11 (2004) 16 D.G. Ouzounov, F.R. Ahmad, D. Müller, N. Venkataraman, M.T. Gal- lagher, M.G. Thomas, J...Silcox, K.W. Koch, A.L. Gaeta: Science 301, 1702 (2003) 17 D.A. Sidorov-Biryukov, S.O. Konorov, V.P. Mitrokhin, A.B. Fedotov, M. Scalora , A.M. Zheltikov...Laser Phys. 14, 5 (2004) 18 M.D. Tocci, M.J. Bloemer, M. Scalora , J.P. Dowling, C.M. Bowden: Appl. Phys. Lett. 66, 2324 (1995) 19 S.O. Konorov, A.B

New coding advances for deep space communications

NASA Technical Reports Server (NTRS)

Yuen, Joseph H.

1987-01-01

Advances made in error-correction coding for deep space communications are described. The code believed to be the best is a (15, 1/6) convolutional code, with maximum likelihood decoding; when it is concatenated with a 10-bit Reed-Solomon code, it achieves a bit error rate of 10 to the -6th, at a bit SNR of 0.42 dB. This code outperforms the Voyager code by 2.11 dB. The use of source statics in decoding convolutionally encoded Voyager images from the Uranus encounter is investigated, and it is found that a 2 dB decoding gain can be achieved.

7 CFR 29.3521 - Grademark.

Code of Federal Regulations, 2013 CFR

2013-01-01

... INSPECTION Standards Official Standard Grades for Dark Air-Cured Tobacco (u.s. Types 35, 36, 37 and Foreign... letters to indicate color. For example, B3D means Heavy Leaf, third quality, and dark-brown color. ...

7 CFR 29.3521 - Grademark.

Code of Federal Regulations, 2014 CFR

2014-01-01

... INSPECTION Standards Official Standard Grades for Dark Air-Cured Tobacco (u.s. Types 35, 36, 37 and Foreign... letters to indicate color. For example, B3D means Heavy Leaf, third quality, and dark-brown color. ...

7 CFR 29.3521 - Grademark.

Code of Federal Regulations, 2011 CFR

2011-01-01

... INSPECTION Standards Official Standard Grades for Dark Air-Cured Tobacco (u.s. Types 35, 36, 37 and Foreign... letters to indicate color. For example, B3D means Heavy Leaf, third quality, and dark-brown color. ...

7 CFR 29.3521 - Grademark.

Code of Federal Regulations, 2010 CFR

2010-01-01

... INSPECTION Standards Official Standard Grades for Dark Air-Cured Tobacco (u.s. Types 35, 36, 37 and Foreign... letters to indicate color. For example, B3D means Heavy Leaf, third quality, and dark-brown color. ...

7 CFR 29.3521 - Grademark.

Code of Federal Regulations, 2012 CFR

2012-01-01

... INSPECTION Standards Official Standard Grades for Dark Air-Cured Tobacco (u.s. Types 35, 36, 37 and Foreign... letters to indicate color. For example, B3D means Heavy Leaf, third quality, and dark-brown color. ...

Measurement of the Cabibbo-Kobayashi-Maskawa Angle {gamma} in B{sup {+-}}{yields}D{sup (*)}K{sup {+-}} Decays with a Dalitz Analysis of D{yields}K{sub S}{sup 0}{pi}{sup -}{pi}{sup +}

DOE Office of Scientific and Technical Information (OSTI.GOV)

Aubert, B.; Barate, R.; Boutigny, D.

2005-09-16

We report on a measurement of the Cabibbo-Kobayashi-Maskawa CP-violating phase {gamma} through a Dalitz analysis of neutral D decays to K{sub S}{sup 0}{pi}{sup -}{pi}{sup +} in the processes B{sup {+-}}{yields}D{sup (*)}K{sup {+-}}, D*{yields}D{pi}{sup 0}, D{gamma}. Using a sample of 227x10{sup 6} BB pairs collected by the BABAR detector, we measure the amplitude ratios r{sub B}=0.12{+-}0.08{+-}0.03{+-}0.04 and r{sub B}*=0.17{+-}0.10{+-}0.03{+-}0.03, the relative strong phases {delta}{sub B}=(104{+-}45{sub -21-24}{sup +17+16}) deg. and {delta}{sub B}*=(-64{+-}41{sub -12}{sup +14}{+-}15) deg. between the amplitudes A(B{sup -}{yields}D{sup (*)0}K{sup -}) and A(B{sup -}{yields}D{sup (*)0}K{sup -}), and {gamma}=(70{+-}31{sub -10-11}{sup +12+14}) deg. The first error is statistical, the second is the experimentalmore » systematic uncertainty, and the third reflects the Dalitz model uncertainty. The results for the strong and weak phases have a twofold ambiguity.« less

Process development for automated solar cell and module production. Task 4: Automated array assembly

NASA Technical Reports Server (NTRS)

Hagerty, J. J.

1981-01-01

The Unimate robot was programmed for the final 35 cell pattern to be used in the fabrication of the deliverable modules. Mechanical construction of the Automated Lamination Station and Final Assembly Station were completed on schedule. All final wiring and interconnect cables were also completed and the first operational testing began. The final controlling program was written. A local fabricator was contracted to produce the glass reinforced concrete panels to be used for testing and deliverables. A video tape showing all three stations in operation was produced.

Shuttle orbiter Ku-band radar/communications system design evaluation. Deliverable test equipment evaluation

NASA Technical Reports Server (NTRS)

Maronde, R. G.

1980-01-01

The Ku-band test equipment, known as the Deliverable System Test equipment (DSTE), is reviewed and evaluated. The DSTE is semiautomated and computer programs were generated for 14 communication mode tests and 17 radar mode tests. The 31 test modules provide a good cross section of tests with which to exercise the Ku-band system; however, it is very limited when being used to verify Ku-band system performance. More detailed test descriptions are needed, and a major area of concern is the DSTE sell-off procedure which is inadequate.

Overview of 3D Documentation Data and Tools available for Archaeological Researches: case study of the Romanesque Church of Dugny-sur-Meuse (France)

NASA Astrophysics Data System (ADS)

Macher, H.; Grussenmeyer, P.; Kraemer, C.; Guillemin, S.

2015-08-01

In this paper, the 3D documentation of the full structure of the Romanesque church of Dugny-sur-Meuse is discussed. In 2012 and 2013, a 3D recording project was carried out under the supervision of the Photogrammetry and Geomatics Research Group from INSA Strasbourg (France) in cooperation with C. Kraemer, archaeologist from Nancy (France). The goal of the project was on one hand to propose new solutions and tools to the archaeologists in charge of the project especially for stone by stone measurements. On the other hand, a simplified 3D model was required by the local authorities for communication purposes. To achieve these goals several techniques were applied namely GNSS measurements and accurate traverse networks, photogrammetric recordings and terrestrial laser scanning acquisitions. The various acquired data are presented in this paper. Based on these data, several deliverables are also proposed. The generation of orthoimages from plane as well as cylindrical surfaces is considered. Moreover, the workflow for the creation of a 3D simplified model is also presented.

Effect of Dissemination of 2,4-Dichlorophenoxyacetic Acid (2,4-D) Degradation Plasmids on 2,4-D Degradation and on Bacterial Community Structure in Two Different Soil Horizons

PubMed Central

Dejonghe, Winnie; Goris, Johan; El Fantroussi, Saïd; Höfte, Monica; De Vos, Paul; Verstraete, Willy; Top, Eva M.

2000-01-01

Transfer of the 2,4-dichlorophenoxyacetic acid (2,4-D) degradation plasmids pEMT1 and pJP4 from an introduced donor strain, Pseudomonas putida UWC3, to the indigenous bacteria of two different horizons (A horizon, depth of 0 to 30 cm; B horizon, depth of 30 to 60 cm) of a 2,4-D-contaminated soil was investigated as a means of bioaugmentation. When the soil was amended with nutrients, plasmid transfer and enhanced degradation of 2,4-D were observed. These findings were most striking in the B horizon, where the indigenous bacteria were unable to degrade any of the 2,4-D (100 mg/kg of soil) during at least 22 days but where inoculation with either of the two plasmid donors resulted in complete 2,4-D degradation within 14 days. In contrast, in soils not amended with nutrients, inoculation of donors in the A horizon and subsequent formation of transconjugants (105 CFU/g of soil) could not increase the 2,4-D degradation rate compared to that of the noninoculated soil. However, donor inoculation in the nonamended B-horizon soil resulted in complete degradation of 2,4-D within 19 days, while no degradation at all was observed in noninoculated soil during 89 days. With plasmid pEMT1, this enhanced degradation seemed to be due only to transconjugants (105 CFU/g of soil), since the donor was already undetectable when degradation started. Denaturing gradient gel electrophoresis (DGGE) of 16S rRNA genes showed that inoculation of the donors was followed by a shift in the microbial community structure of the nonamended B-horizon soils. The new 16S rRNA gene fragments in the DGGE profile corresponded with the 16S rRNA genes of 2,4-D-degrading transconjugant colonies isolated on agar plates. This result indicates that the observed change in the community was due to proliferation of transconjugants formed in soil. Overall, this work clearly demonstrates that bioaugmentation can constitute an effective strategy for cleanup of soils which are poor in nutrients and microbial activity, such as those of the B horizon. PMID:10919784

The Effect of Doppler Frequency Shift, Frequency Offset of the Local Oscillators, and Phase Noise on the Performance of Coherent OFDM Receivers

NASA Technical Reports Server (NTRS)

Xiong, Fuqin; Andro, Monty

2001-01-01

This paper first shows that the Doppler frequency shift affects the frequencies of the RF carrier, subcarriers, envelope, and symbol timing by the same percentage in an Orthogonal Frequency Division Multiplexing (OFDM) signal or any other modulated signals. Then the SNR degradation of an OFDM system due to Doppler frequency shift, frequency offset of the local oscillators and phase noise is analyzed. Expressions are given and values for 4-, 16-, 64-, and 256-QAM OFDM systems are calculated and plotted. The calculations show that the Doppler shift of the D3 project is about 305 kHz, and the degradation due to it is about 0.01 to 0.04 dB, which is negligible. The degradation due to frequency offset and phase noise of local oscillators will be the main source of degradation. To keep the SNR degradation under 0.1 dB, the relative frequency offset due to local oscillators must be below 0.01 for the 16 QAM-OFDM. This translates to an offset of 1.55 MHz (0.01 x 155 MHz) or a stability of 77.5 ppm (0.01 x 155 MHz/20 GHz) for the DI project. To keep the SNR degradation under 0.1 dB, the relative linewidth (0) due to phase noise of the local oscillators must be below 0.0004 for the 16 QAM-OFDM. This translates to a linewidth of 0.062 MHz (0.0004 x 155 MHz) of the 20 GHz RIF carrier. For a degradation of 1 dB, beta = 0.04, and the linewidth can be relaxed to 6.2 MHz.

A Policy Analysis of Reserve Retirement Reform

DTIC Science & Technology

2013-01-01

of the basic pay bill for the AC force, consistent with the practice of the DoD Actuary . This gives an amount, an accrual charge, sufficient to cover...accrual charges made during its AC service. This also follows the practice of the DoD Actuary . Specifically, the amount transferred from the AC...retirement reform. 16 The actuarial calculation is made for those leaving AC by AC year of service. For example, consider 100 AC service members in

H2FIRST Reference Station Design Task: Project Deliverable 2-2

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pratt, Joseph; Terlip, Danny; Ainscough, Chris

2015-04-20

This report presents near-term station cost results and discusses cost trends of different station types. It compares various vehicle rollout scenarios and projects realistic near-term station utilization values using the station infrastructure rollout in California as an example. It describes near-term market demands and matches those to cost-effective station concepts. Finally, the report contains detailed designs for five selected stations, which include piping and instrumentation diagrams, bills of materials, and several site-specific layout studies that incorporate the setbacks required by NFPA 2, the National Fire Protection Association Hydrogen Technologies Code. This work identified those setbacks as a significant factor affectingmore » the ability to site a hydrogen station, particularly liquid stations at existing gasoline stations. For all station types, utilization has a large influence on the financial viability of the station.« less

VLSI for High-Speed Digital Signal Processing

DTIC Science & Technology

1994-09-30

particular, the design, layout and fab - rication of integrated circuits. The primary project for this grant has been the design and implementation of a...targeted at 33.36 dB, and PSNR (dB) Rate ( bpp ) the FRSBC algorithm, targeted at 0.5 bits/pixel, respec- Filter FDSBC FRSBC FDSBC FRSBC tively. The filter...to mean square error d by as shown in Fig. 6, is used, yielding a total of 16 subbands. 255’ The rates, in bits per pixel ( bpp ), and the peak signal

Classroom Materials for Job-Related BSEP 2 Program

DTIC Science & Technology

1983-09-01

gathered D. gathered, combined, camoufl age 10. The greedy man was happy to take the money. A. greedy C. was *B. was happy D. take 11. The banana ...tastes good with peanut butter on it. A. tastes C. tastes good B. on D. banana III. Instructions: You are given a choice of two verbs in the following...previously o.- before. (The M16 had ALREADY been fired.) 162 peel Grammar Activity Sheet 36A Good Usage of English Name 6. ALL RIGHT - "ALRIGHT" ALL RIGHT

Exploitation of Unintentional Ethernet Cable Emissions Using Constellation Based-Distinct Native Attribute (CB-DNA) Fingerprints to Enhance Network Security

DTIC Science & Technology

2015-09-17

Exploitation of Unintentional Information Leakage from Inte- grated Circuits”. Ph.D. dissertation, ECE, AFIT, Wright- Patt AFB, OH, 2011. 16. Cobb, W. E...Ph.D. dissertation, ECE, AFIT, Wright- Patt AFB, OH, 2014. 48. Ramsey, B. W., Temple, M. A., and Mullins, B. E. PHY Foundation for Multi-Factor...dissertation, ECE, AFIT, Wright- Patt AFB, OH, 2012. 132 51. Reising, D. R., Temple, M. A., and Oxley, M. E. Gabor-Based RF-DNA Fingerprinting for

Small-Scale Tests of MX Vertical Shelter Structures.

DTIC Science & Technology

1983-06-29

models were built with as much geometric and material similitude as practical. They 7were not identical to the 1/3-scale structures tested in the VST ...comparison with the 1/30-scale models and the 1/6-scale models, the 1/3-scale VST 7 models had different geometry (wall thickness variations), different...1/30-scale and 1/6-scale results with the 1/3-scale VST results. For example, the strains measured in the 1/3-scale ’B’ structure are about twice as

United States Air Force Health Care Provider Practices: Skin Testing for Mycobacterium Tuberculosis

DTIC Science & Technology

1997-04-03

first, with 16 possible correct answers, was calculated using the formula: Total score = a + b + c + d + e + f +g + h + i + j-i-k + l + m + n + o + p...In The Literature 32 F . Gaps In Knowledge 34 Xlll CHAPTER THREE: METHODOLOGY A . Introduction 36 B. Research Design and Procedures 36 C . Research...The second, with 10 possible correct responses, was calculated using the formula: Total score = a + b + c + d + e + f +g + h + i+ j . The reasons for

Polarizations in B→VV decays

NASA Astrophysics Data System (ADS)

Li, Hsiang-Nan; Mishima, Satoshi

2005-03-01

We demonstrate that the polarization fractions of most tree-dominated B→VV decays can be simply understood by means of kinematics in the heavy-quark or large-energy limit. For example, the longitudinal polarization fractions RL of the B0→(D*+s,D*+,ρ+)D*- and B+→(D*+s,D*+,ρ+)ρ0 modes increase as the masses of the mesons D*+s,D*+,ρ+ emitted from the weak vertex decrease. The subleading finite-mass or finite-energy corrections modify these simple estimates only slightly. Our predictions for the B→D*(s)D* polarization fractions derived in the perturbative QCD framework, especially RL˜1 for B0→D¯*0D*0 governed by nonfactorizable W-exchange amplitudes, can be confronted with future data. For penguin-dominated modes, such as B→ρ(ω)K*, the polarization fractions can be understood by the annihilation effect from the (S-P)(S+P) operators, plus the interference with a small tree amplitude. At last, we comment on the various mechanisms proposed in the literature to explain the abnormal B→ϕK* polarization data, none of which are satisfactory.

Electromagnetics and Electrothermal Approach to Evaluate Failures in Microelectronic Devices Caused by Electrostatic Discharges: Stochastical Aspects of the Device Reliability.

DTIC Science & Technology

1987-08-01

C C CALL THE ELSV SUBROUTINE TO INVERT THE MATRIX. EPO .1D-09 . CALL ELSV(Z,AUX1,AUX2,tN, DE ,EP) WRITE(93,118) DE 118 FORMAT(5X,’ DE -,1E) C C MULTIPLY...IFCABS(W).LT.EP)GO TO 17 DO 13 I=1,N Y’=A( I,K)/W DO 13 J=1,N 13 AC I,J)=A(I,J)-B(J)*Y DE =O.DO DO.15 J=1,N B(J)0O.DO DO 16 I=1,N 16 B(J)=B(J)+A(I,J...15 DE - DE +C(J)*B(J) RETURN 1. DE -1.DO RETURN -18- IMPLICIT COMPLEX*16 (C) IMPLICIT REAL*8 (A-B,E-H,P-z) C C C THIS PROGRAM GIVES THE POTENTIAL AND THE

16 CFR 1102.44 - Applicability of sections 6(a) and (b) of the CPSA.

Code of Federal Regulations, 2011 CFR

2011-01-01

... PRODUCT SAFETY ACT REGULATIONS PUBLICLY AVAILABLE CONSUMER PRODUCT SAFETY INFORMATION DATABASE (Eff. Jan... publication in § 1102.10(d) in the Database. (b) Limitation on construction. Section 1102.44(a) shall not be...

16 CFR § 1102.44 - Applicability of sections 6(a) and (b) of the CPSA.

Code of Federal Regulations, 2013 CFR

2013-01-01

... CONSUMER PRODUCT SAFETY ACT REGULATIONS PUBLICLY AVAILABLE CONSUMER PRODUCT SAFETY INFORMATION DATABASE... § 1102.10(d) in the Database. (b) Limitation on construction. Section 1102.44(a) shall not be construed...

Highly Directional Sonar Beam of Narwhals (Monodon monoceros) Measured with a Vertical 16 Hydrophone Array.

PubMed

Koblitz, Jens C; Stilz, Peter; Rasmussen, Marianne H; Laidre, Kristin L

2016-01-01

Recordings of narwhal (Monodon monoceros) echolocation signals were made using a linear 16 hydrophone array in the pack ice of Baffin Bay, West Greenland in 2013 at eleven sites. An average -3 dB beam width of 5.0° makes the narwhal click the most directional biosonar signal reported for any species to date. The beam shows a dorsal-ventral asymmetry with a narrower beam above the beam axis. This may be an evolutionary advantage for toothed whales to reduce echoes from the water surface or sea ice surface. Source level measurements show narwhal click intensities of up to 222 dB pp re 1 μPa, with a mean apparent source level of 215 dB pp re 1 μPa. During ascents and descents the narwhals perform scanning in the vertical plane with their sonar beam. This study provides valuable information for reference sonar parameters of narwhals and for the use of acoustic monitoring in the Arctic.

Highly Directional Sonar Beam of Narwhals (Monodon monoceros) Measured with a Vertical 16 Hydrophone Array

PubMed Central

Koblitz, Jens C.; Stilz, Peter; Rasmussen, Marianne H.; Laidre, Kristin L.

2016-01-01

Recordings of narwhal (Monodon monoceros) echolocation signals were made using a linear 16 hydrophone array in the pack ice of Baffin Bay, West Greenland in 2013 at eleven sites. An average -3 dB beam width of 5.0° makes the narwhal click the most directional biosonar signal reported for any species to date. The beam shows a dorsal-ventral asymmetry with a narrower beam above the beam axis. This may be an evolutionary advantage for toothed whales to reduce echoes from the water surface or sea ice surface. Source level measurements show narwhal click intensities of up to 222 dB pp re 1 μPa, with a mean apparent source level of 215 dB pp re 1 μPa. During ascents and descents the narwhals perform scanning in the vertical plane with their sonar beam. This study provides valuable information for reference sonar parameters of narwhals and for the use of acoustic monitoring in the Arctic. PMID:27828956

Joint OSNR monitoring and modulation format identification in digital coherent receivers using deep neural networks.

PubMed

Khan, Faisal Nadeem; Zhong, Kangping; Zhou, Xian; Al-Arashi, Waled Hussein; Yu, Changyuan; Lu, Chao; Lau, Alan Pak Tao

2017-07-24

We experimentally demonstrate the use of deep neural networks (DNNs) in combination with signals' amplitude histograms (AHs) for simultaneous optical signal-to-noise ratio (OSNR) monitoring and modulation format identification (MFI) in digital coherent receivers. The proposed technique automatically extracts OSNR and modulation format dependent features of AHs, obtained after constant modulus algorithm (CMA) equalization, and exploits them for the joint estimation of these parameters. Experimental results for 112 Gbps polarization-multiplexed (PM) quadrature phase-shift keying (QPSK), 112 Gbps PM 16 quadrature amplitude modulation (16-QAM), and 240 Gbps PM 64-QAM signals demonstrate OSNR monitoring with mean estimation errors of 1.2 dB, 0.4 dB, and 1 dB, respectively. Similarly, the results for MFI show 100% identification accuracy for all three modulation formats. The proposed technique applies deep machine learning algorithms inside standard digital coherent receiver and does not require any additional hardware. Therefore, it is attractive for cost-effective multi-parameter estimation in next-generation elastic optical networks (EONs).

FPGA-based rate-adaptive LDPC-coded modulation for the next generation of optical communication systems.

PubMed

Zou, Ding; Djordjevic, Ivan B

2016-09-05

In this paper, we propose a rate-adaptive FEC scheme based on LDPC codes together with its software reconfigurable unified FPGA architecture. By FPGA emulation, we demonstrate that the proposed class of rate-adaptive LDPC codes based on shortening with an overhead from 25% to 42.9% provides a coding gain ranging from 13.08 dB to 14.28 dB at a post-FEC BER of 10^-15 for BPSK transmission. In addition, the proposed rate-adaptive LDPC coding combined with higher-order modulations have been demonstrated including QPSK, 8-QAM, 16-QAM, 32-QAM, and 64-QAM, which covers a wide range of signal-to-noise ratios. Furthermore, we apply the unequal error protection by employing different LDPC codes on different bits in 16-QAM and 64-QAM, which results in additional 0.5dB gain compared to conventional LDPC coded modulation with the same code rate of corresponding LDPC code.

KI Sawyer AFB, Gwinn, Michigan. Revised Uniform Summary of Surface Weather Observations (RUSSWO). Parts A-F

DTIC Science & Technology

1979-04-26

26127.28j29-301 ,31 0.B- "B-’D,,B Ib1W.’ Boi b-!W .. o.oA 80/ 79 1 I .0i 1. ._ 61 6a 76/ 75 t .01 .01 1 .01 .0 5, 51 o , .0 .oi oi , . o.. oi_ ___ 5, 674/ 73...1213. 1115. 16-17. 18!19.20:21-22123.24i25-26;27.28i29.301 -31 B’W.B8’D. y Bulb, ctWeBvlh.e Porne - 42/ 41 .2.1’ , 3 3 2 2[ 4O0/_9, _ _ _ _ _3 3’ 4

Effects of Amino Acids on Melanoma Targeting and Clearance Properties of Tc-99m-Labeled Arg-X-Asp-Conjugated α-Melanocyte Stimulating Hormone Peptides

PubMed Central

Flook, Adam M.; Yang, Jianquan; Miao, Yubin

2013-01-01

The purpose of this study was to examine the effects of amino acids on melanoma targeting and clearance properties of new 99mTc-labeled Arg-X-Asp-conjugated alpha-melanocyte stimulating hormone (α-MSH) peptides. RSD-Lys-(Arg11)CCMSH {c[Arg-Ser-Asp-dTyr-Asp]-Lys-Cys-Cys-Glu-His-dPhe-Arg-Trp-Cys-Arg-Pro-Val-NH2}, RNleD-Lys-(Arg11)CCMSH, RPheD-Lys-(Arg11)CCMSH and RdPheD-Lys-(Arg11)CCMSH peptides were synthesized and evaluated for their melanocortin-1 (MC1) receptor binding affinities in B16/F1 melanoma cells. The biodistribution of 99mTc-RSD-Lys-(Arg11)CCMSH, 99mTc-RFD-Lys-(Arg11)CCMSH and 99mTc-RfD-Lys-(Arg11)CCMSH were determined in B16/F1 melanoma-bearing C57 mice. The substitution of Gly with Ser, Phe and dPhe increased the MC1 receptor binding affinities of the peptides, whereas the substitution of Gly with Nle decreased the MC1 receptor binding affinity of the peptide. 99mTc-RSD-Lys-(Arg11)CCMSH exhibited the highest melanoma uptake (18.01 ± 4.22% ID/g) and the lowest kidney and liver uptake among these 99mTc-peptides. The B16/F1 melanoma lesions could be clearly visualized by SPECT/CT using 99mTc-RSD-Lys-(Arg11)CCMSH as an imaging probe. It is desirable to reduce the renal uptake of 99mTc-RSD-Lys-(Arg11)CCMSH to facilitate its potential therapeutic application. PMID:24131154

16 CFR 255.3 - Expert endorsements.

Code of Federal Regulations, 2013 CFR

2013-01-01

... message, then the endorser's qualifications must in fact give the endorser the expertise that he or she is... in fact have found such superiority. [See § 255.1(d) regarding the liability of endorsers.] Example 1... that its products are approved by the “American Institute of Science.”From its name, consumers would...

16 CFR 255.3 - Expert endorsements.

Code of Federal Regulations, 2011 CFR

2011-01-01

... message, then the endorser's qualifications must in fact give the endorser the expertise that he or she is... in fact have found such superiority. [See § 255.1(d) regarding the liability of endorsers.] Example 1... that its products are approved by the “American Institute of Science.”From its name, consumers would...

16 CFR 255.3 - Expert endorsements.

Code of Federal Regulations, 2012 CFR

2012-01-01

... message, then the endorser's qualifications must in fact give the endorser the expertise that he or she is... in fact have found such superiority. [See § 255.1(d) regarding the liability of endorsers.] Example 1... that its products are approved by the “American Institute of Science.”From its name, consumers would...

16 CFR 255.3 - Expert endorsements.

Code of Federal Regulations, 2010 CFR

2010-01-01

... message, then the endorser's qualifications must in fact give the endorser the expertise that he or she is... in fact have found such superiority. [See § 255.1(d) regarding the liability of endorsers.] Example 1... that its products are approved by the “American Institute of Science.”From its name, consumers would...

16 CFR 255.3 - Expert endorsements.

Code of Federal Regulations, 2014 CFR

2014-01-01

... message, then the endorser's qualifications must in fact give the endorser the expertise that he or she is... in fact have found such superiority. [See § 255.1(d) regarding the liability of endorsers.] Example 1... that its products are approved by the “American Institute of Science.”From its name, consumers would...

Adverse external ocular effects of topical ophthalmic therapy: an epidemiologic, laboratory, and clinical study.

PubMed Central

Wilson, F M

1983-01-01

New knowledge of adverse external ocular reactions to topical ophthalmic medications was obtained by means of a computerized epidemiologic study, laboratory studies, and clinical observations. Listed below are the major findings and conclusions that represent facts or concepts that were previously unknown, uncertain, misunderstood, or forgotten: The incidence of clinically important drug reactions among all cases was at least 13.09% and may have been as high as 16.02%. Among treated patients it was at least 16.26% to 19.90%. Taken together, drug reactions were the second most common external disease diagnosis. The incidence of each kind of drug reaction was determined. Toxic papillary reactions accounted for 79.10% of drug cases and 10.35% of all cases. Toxic papillary keratoconjunctivitis was the third most common single diagnosis. The following epidemiologic factors were found to be related to the development or presence of drug reactions: number and variety of treating practitioners, number of practitioners consulted, number of practitioners consulted who treated, specific ophthalmologist consulted (8.24% of ophthalmologists referred 39.55% of all drug cases and showed a tendency habitually to overtreat), number and kinds of patients' symptomatic complaints, number of medications prescribed and used, number of days of treatment, particular drugs and preservatives used (but not their strengths or vehicles), underlying (primary) diagnoses, and inaccuracy of referring ophthalmologists' diagnoses. Patients with dry eyes were especially at risk for the development of toxic papillary reactions. Among all cases, the incidence of reactions to preservatives (mainly thimerosal) in contact lens solutions was 0.39% to 1.95%, depending on whether definite or probable cases, respectively, were considered. The incidence among the 54 patients who used daily-wear lenses (excluding extended-wear therapeutic and optical contacts) was 7.41% for definite reactions and 37.04% for probable ones. Factors relating to the development of papillary contact-lens reactions were daily wear, number of days of wear, and, especially, the preservatives to which the patients were exposed. Reactions occurred more often with soft lenses than with hard ones. Of patients with drug reactions, 5.22% had two different ones simultaneously. Coexisting reactions to pharmacologically active agents were also present in 15% of patients who reacted to preservatives in contact lens solutions. The ocular tissues that were affected by each kind of drug reaction were tabulated, and the relative degrees and sequences of involvement were discussed. The frequencies with which particular drugs, physical ag Images FIGURE 2 A FIGURE 2 B FIGURE 15 A FIGURE 15 B FIGURE 1 FIGURE 3 FIGURE 4 A FIGURE 4 B FIGURE 5 A FIGURE 5 B FIGURE 5 C FIGURE 5 D FIGURE 6 A FIGURE 6 B FIGURE 6 C FIGURE 7 A FIGURE 7 B FIGURE 8 A FIGURE 8 B FIGURE 9 A FIGURE 9 B FIGURE 9 C FIGURE 9 D FIGURE 10 A FIGURE 10 B FIGURE 10 C FIGURE 10 D FIGURE 11 A FIGURE 11 B FIGURE 11 C FIGURE 11 D FIGURE 12 A FIGURE 12 B FIGURE 12 C FIGURE 12 D FIGURE 14 FIGURE 16 A FIGURE 16 B FIGURE 18 FIGURE 19 A FIGURE 19 B FIGURE 20 A FIGURE 20 B FIGURE 21 A FIGURE 21 B FIGURE 22 A FIGURE 22 B FIGURE 22 C FIGURE 23 A FIGURE 23 B FIGURE 23 C FIGURE 23 D PMID:6676985

Cochlear Implant Electrode Array From Partial to Full Insertion in Non-Human Primate Model.

PubMed

Manrique-Huarte, Raquel; Calavia, Diego; Gallego, Maria Antonia; Manrique, Manuel

2018-04-01

To determine the feasibility of progressive insertion (two sequential surgeries: partial to full insertion) of an electrode array and to compare functional outcomes. 8 normal-hearing animals (Macaca fascicularis (MF)) were included. A 14 contact electrode array, which is suitably sized for the MF cochlea was partially inserted (PI) in 16 ears. After 3 months of follow-up revision surgery the electrode was advanced to a full insertion (FI) in 8 ears. Radiological examination and auditory testing was performed monthly for 6 months. In order to compare the values a two way repeated measures ANOVA was used. A p-value below 0.05 was considered as statistically significant. IBM SPSS Statistics V20 was used. Surgical procedure was completed in all cases with no complications. Mean auditory threshold shift (ABR click tones) after 6 months follow-up is 19 dB and 27 dB for PI and FI group. For frequencies 4, 6, 8, 12, and 16 kHz in the FI group, tone burst auditory thresholds increased after the revision surgery showing no recovery thereafter. Mean threshold shift at 6 months of follow- up is 19.8 dB ranging from 2 to 36dB for PI group and 33.14dB ranging from 8 to 48dB for FI group. Statistical analysis yields no significant differences between groups. It is feasible to perform a partial insertion of an electrode array and progress on a second surgical time to a full insertion (up to 270º). Hearing preservation is feasible for both procedures. Note that a minimal threshold deterioration is depicted among full insertion group, especially among high frequencies, with no statistical differences.

The 20 GHz GaAs monolithic power amplifier module development

NASA Technical Reports Server (NTRS)

1984-01-01

The development of a 20 GHz GaAs FET monlithic power amplifier module for advanced communication applications is described. Four-way power combing of four 0.6 W amplifier modules is used as the baseline approach. For this purpose, a monolithic four-way traveling-wave power divider/combiner was developed. Over a 20 GHz bandwidth (10 to 30 GHz), an insertion loss of no more than 1.2 dB was measured for a pair of back-to-back connected divider/combiners. Isolation between output ports is better than 20 dB, and VSWRs are better than 21:1. A distributed amplifier with six 300 micron gate width FETs and gate and drain transmission line tapers has been designed, fabricated, and evaluated for use as an 0.6 W module. This amplifier has achieved state-of-the-art results of 0.5 W output power with at least 4 dB gain across the entire 2 to 21 GHz frequency range. An output power of 2 W was achieved at a measurement frequency of 18 GHz when four distributed amplifiers were power-combined using a pair of traveling-wave divider/combiners. Another approach is the direct common-source cascading of three power FET stages. An output power of up to 2W with 12 dB gain and 20% power-added efficiency has been achieved with this approach (at 17 GHz). The linear gain was 14 dB at 1 W output. The first two stages of the three-stage amplifier have achieved an output power of 1.6 W with 9 dB gain and 26% power-added efficiency at 16 GHz.

Detection and characterization of murine colitis and carcinogenesis by molecularly targeted contrast-enhanced ultrasound

PubMed Central

Brückner, Markus; Heidemann, Jan; Nowacki, Tobias M; Cordes, Friederike; Stypmann, Jörg; Lenz, Philipp; Gohar, Faekah; Lügering, Andreas; Bettenworth, Dominik

2017-01-01

AIM To study mucosal addressin cellular adhesion molecule-1 (MAdCAM-1) and vascular endothelial growth factor (VEGF)-targeted contrast enhanced ultrasound (CEUS) for the assessment of murine colitis and carcinogenesis. METHODS C57BL/6 mice were challenged with 3% dextran sodium-sulfate (DSS) for three, six or nine days to study the development of acute colitis. Ultrasound was performed with and without the addition of unspecific contrast agents. MAdCAM-1-targeted contrast agent was used to detect and quantify MAdCAM-1 expression. Inflammatory driven colorectal azoxymethane (AOM)/DSS-induced carcinogenesis was examined on day 42 and 84 using VEGF-targeted contrast agent. Highly specific tissue echogenicity was quantified using specialized software. Sonographic findings were correlated to tissue staining, western blot analysis and immunohistochemistry to quantify the degree of inflammation and stage of carcinogenesis. RESULTS Native ultrasound detected increased general bowel wall thickening that correlated with more progressed and more severe DSS-colitis (healthy mice: 0.3 mm ± 0.03 vs six days DSS: 0.5 mm ± 0.2 vs nine days DSS: 0.6 mm ± 0.2, P < 0.05). Moreover, these sonographic findings correlated well with clinical parameters such as weight loss (r2 = 0.74) and histological damage (r2 = 0.86) (P < 0.01). In acute DSS-induced murine colitis, CEUS targeted against MAdCAM-1 detected and differentiated stages of mild, moderate and severe colitis via calculation of mean pixel contrast intensity in decibel (9.6 dB ± 1.6 vs 12.9 dB ± 1.4 vs 18 dB ± 3.33, P < 0.05). Employing the AOM/DSS-induced carcinogenesis model, tumor development was monitored by CEUS targeted against VEGF and detected a significantly increased echogenicity in tumors as compared to adjacent healthy mucosa (healthy mucosa, 1.6 dB ± 1.4 vs 42 d, 18.2 dB ± 3.3 vs 84 d, 18.6 dB ± 4.9, P < 0.01). Tissue echogenicity strongly correlated with histological analysis and immunohistochemistry findings (VEGF-positive cells in 10 high power fields of healthy mucosa: 1 ± 1.2 vs 42 d after DSS start: 2.4 ± 1.6 vs 84 d after DSS start: 3.5 ± 1.3, P < 0.01). CONCLUSION Molecularly targeted CEUS is a highly specific and non-invasive imaging modality, which characterizes murine intestinal inflammation and carcinogenesis in vivo. PMID:28522908

Detection and characterization of murine colitis and carcinogenesis by molecularly targeted contrast-enhanced ultrasound.

PubMed

Brückner, Markus; Heidemann, Jan; Nowacki, Tobias M; Cordes, Friederike; Stypmann, Jörg; Lenz, Philipp; Gohar, Faekah; Lügering, Andreas; Bettenworth, Dominik

2017-04-28

To study mucosal addressin cellular adhesion molecule-1 (MAdCAM-1) and vascular endothelial growth factor (VEGF)-targeted contrast enhanced ultrasound (CEUS) for the assessment of murine colitis and carcinogenesis. C57BL/6 mice were challenged with 3% dextran sodium-sulfate (DSS) for three, six or nine days to study the development of acute colitis. Ultrasound was performed with and without the addition of unspecific contrast agents. MAdCAM-1-targeted contrast agent was used to detect and quantify MAdCAM-1 expression. Inflammatory driven colorectal azoxymethane (AOM)/DSS-induced carcinogenesis was examined on day 42 and 84 using VEGF-targeted contrast agent. Highly specific tissue echogenicity was quantified using specialized software. Sonographic findings were correlated to tissue staining, western blot analysis and immunohistochemistry to quantify the degree of inflammation and stage of carcinogenesis. Native ultrasound detected increased general bowel wall thickening that correlated with more progressed and more severe DSS-colitis (healthy mice: 0.3 mm ± 0.03 vs six days DSS: 0.5 mm ± 0.2 vs nine days DSS: 0.6 mm ± 0.2, P < 0.05). Moreover, these sonographic findings correlated well with clinical parameters such as weight loss ( r 2 = 0.74) and histological damage ( r 2 = 0.86) ( P < 0.01). In acute DSS-induced murine colitis, CEUS targeted against MAdCAM-1 detected and differentiated stages of mild, moderate and severe colitis via calculation of mean pixel contrast intensity in decibel (9.6 dB ± 1.6 vs 12.9 dB ± 1.4 vs 18 dB ± 3.33, P < 0.05). Employing the AOM/DSS-induced carcinogenesis model, tumor development was monitored by CEUS targeted against VEGF and detected a significantly increased echogenicity in tumors as compared to adjacent healthy mucosa (healthy mucosa, 1.6 dB ± 1.4 vs 42 d, 18.2 dB ± 3.3 vs 84 d, 18.6 dB ± 4.9, P < 0.01). Tissue echogenicity strongly correlated with histological analysis and immunohistochemistry findings (VEGF-positive cells in 10 high power fields of healthy mucosa: 1 ± 1.2 vs 42 d after DSS start: 2.4 ± 1.6 vs 84 d after DSS start: 3.5 ± 1.3, P < 0.01). Molecularly targeted CEUS is a highly specific and non-invasive imaging modality, which characterizes murine intestinal inflammation and carcinogenesis in vivo .

26 CFR 1.1274A-1 - Special rules for certain transactions where stated principal amount does not exceed $2,800,000.

Code of Federal Regulations, 2010 CFR

2010-04-01

... interests in Blackacre to B. The sales are pursuant to a plan for the sale of a 100 percent interest in... debt instruments. (b) Rules for both qualified and cash method debt instruments—(1) Sale-leaseback... section 1274A(d)(1) and paragraph (b)(3)(i) of this section. Example 1. Aggregation of two sales to a...

The savant syndrome and extrasensory perception.

PubMed

McMullen, T

1991-12-01

D.A. Treffert, following B. Rimland, cited examples which he states show ESP to be occurring in certain autistic savant children. The evidence is questioned on the ground that it is hearsay, uncorroborated by independent scrutiny.

A novel melanin inhibitor: hydroperoxy traxastane-type triterpene from flowers of Arnica montana.

PubMed

Maeda, Kazuhisa; Naitou, Tomoko; Umishio, Kenichi; Fukuhara, Tadao; Motoyama, Akira

2007-05-01

We isolated a novel inhibitor of melanin biosynthesis from the flowers of Arnica montana L. (Compositae), and identified it as a traxastane-type triterpene (3beta,16beta-dihydroxy-21alpha-hydroperoxy-20(30)-taraxastene) [1] by means of 1D or 2D-NMR and liquid chromatography/high-resolution mass spectrometry (LC-HR-MS). Compound [1] at the concentration of 0.53 muM completely inhibited melanin accumulation in cultured B16 melanoma cells. It is one of the most potent among known plant inhibitors of melanin biosynthesis in cultured cells, being 50 times more potent than 4-methoxyphenol, which is used as an anti-pigmentation agent. Its mechanism of action is considered to involve inhibition of transcriptional factor MITF-M (melanocyte-type isoform of microphthalmia-associated transcription factor), which would lead to a decrease of tyrosinase and related genes. We confirmed that compound [1] decreased the protein levels of tyrosinase and its related proteins in B16 melanoma cells. Further study revealed that a similar hydroperoxy triterpene also suppressed the melanin pigment accumulation of B16 melanoma cells. These results indicate that the hydroperoxy group may play an important role in the suppression of the melanin accumulation by compound [1].

75 FR 16152 - National Heart, Lung, and Blood Institute; Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-31

... sections 552b(c)(4) and 552b(c)(6), Title 5 U.S.C., as amended. The grant applications and the discussions..., MD 20892. Contact Person: Stephen C. Mockrin, Ph.D., Director, Division of Extramural Research... show one form of identification (for example, a government-issued photo ID, driver's license, or...

78 FR 25458 - National Eye Institute; Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-01

... the public in accordance with the provisions set forth in sections 552b(c)(4) and 552b(c)(6), Title 5..., Bethesda, MD 20892. Contact Person: Lore Anne McNicol, Ph.D., Director, Division of Extramural Research... will be asked to show one form of identification (for example, a government-issued photo ID, driver's...

78 FR 28229 - National Heart, Lung, and Blood Institute; Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-14

... sections 552b(c)(4) and 552b(c)(6), Title 5 U.S.C., as amended. The grant applications and/or contract...: Stephen C. Mockrin, Ph.D., Director, Division of Extramural Research Activities, National Heart, Lung, and... example, a government-issued photo ID, driver's license, or passport) and to state the purpose of their...

Force-moment line element method for flexible slender bodies in Stokes flow.

PubMed

Jiang, H; Yang, B

2013-09-01

The hydrodynamics of flexible slender bodies in Stokes flow is studied by taking into account the fluid-structure interaction through both forces and coupled moments. The fluid subjected to line sources of forces and moments is described by using integral equations. Meanwhile, the flexible slender body is modeled using finite beam elements. The two sides are linked through interfacial continuity conditions. Upon discretization, it results in a higher-order line element method for efficient and accurate solution of slender-body hydrodynamics. Four examples are presented to demonstrate the validity and efficiency of the present method: (a) hydrodynamics of a flexible slender rod subjected to a torque at one end, (b) hydrodynamics of a flexible slender rod subjected to a bending moment at one end, (c) hydrodynamics of a flexible slender rod subjected to a cyclic force, and (d) hydrodynamics of a flexible slender rod with a magnetized head within a rotating magnetic field. Examples (a) and (b) may serve as benchmark solutions and examples (c) and (d) show how planar and spiral waves can be excited in a slender body.

High-performance 16-way Ku-band radial power combiner based on the TE01-circular waveguide mode

NASA Astrophysics Data System (ADS)

Montejo-Garai, José R.; Saracho-Pantoja, Irene O.; Ruiz-Cruz, Jorge A.; Rebollar, Jesús M.

2018-03-01

This work presents a 16-way Ku-band radial power combiner for high power and high frequency applications, using the very low loss TE01 circular waveguide mode. The accomplished design shows an excellent performance: the experimental prototype has a return loss better than 30 dB, with a balance for the amplitudes of (±0.15 dB) and (±2.5°) for the phases, in a 16.7% fractional bandwidth (2 GHz centered at 12 GHz). For obtaining these outstanding specifications, required, for instance, in high-frequency amplification or on plasma systems, a rigorous step-by-step procedure is presented. First, a high-purity mode transducer has been designed, from the TE10 mode in the rectangular waveguide to the TE01 mode in the circular waveguide, with very high attenuation (>50 dB) for the other propagating and evanescent modes in the circular waveguide. This transducer has been manufactured and measured in a back-to-back configuration, validating the design process. Second, an E-plane 16-way radial power divider has been designed, where the power is coupled from the 16 non-reduced-height radial standard waveguides into the TE01 circular waveguide mode, improving the insertion loss response and removing the usual tapered transformers of previous designs limiting the power handling. Finally, both the transducer and the divider have been assembled to make the final radial combiner. The prototype has been carefully manufactured, showing very good agreement between the measurements and the full-wave simulations.

Design of synthetic soil images using the Truncated Multifractal method

NASA Astrophysics Data System (ADS)

Sotoca, Juan J. Martin; Saa-Requejo, Antonio; López de Herrera, Juan; Grau, Juan B.

2017-04-01

The use of synthetic images in soils is an increasingly used resource when comparing different segmentation methods. This type of images can simulate features of the real soil images. We can find examples of 2D and 3D synthetic soil images in the studies by Zhang (2001), Schlüter et al. (2010) and Wang et al. (2011). The aim of this presentation is to show an improved version of the Truncated Multifractal method (TMM) which was initially introduced by Martín-Sotoca et al. (2016a, 2016b). The TMM is able to construct a 3D synthetic soil image that is composed of a known air-filled pore space and a background space, which includes, as a novelty, a pebble space. The pebble space simulates the pebbles or granules of high intensity that typically appear in computed tomography (CT) soil images. The TMM can simulate the two main characteristics of the CT soil images: the scaling nature of the pore space and the low contrast at the solid/pore interface with non-bimodal greyscale value histograms. In this presentation we introduce some new components which improve the similitude between real and synthetic CT soil images. REFERENCES Martín-Sotoca, J.J., Saa-Requejo, A., Grau, J.B. and Tarquis, A.M. (2016a). New segmentation method based on fractal properties using singularity maps. Geoderma, doi: 10.1016/j.geoderma.2016.09.005 Martín-Sotoca, J.J., Saa-Requejo, A., Grau, J.B., Tarquis, A.M. (2016b). Local 3D segmentation of soil pore space based on fractal properties using singularity maps. Geoderma, doi: 10.1016/j.geoderma.2016.11.029 Schlüter, S., Weller, U., Vogel, H.J., (2010). Thresholding of X-ray microtomography images of soil using gradient masks. Comput. Geosci. 36, 1246-1251 Wang, W., Kravchenko, A.N., Smucker, A.J.M., Rivers, M.L. (2011). Comparison of image segmentation methods in simulated 2D and 3D microtomographic images of soil aggregates. Geoderma, 162, 231-241 Zhang, Y.J. (2001). A review of recent evaluation methods for image segmentation: International symposium on signal processing and its applications. Kuala Lumpur, Malaysia, 13-16, pp. 148-151

Implementation of the Phase Difference Trace Function for a Circular Array.

DTIC Science & Technology

1980-06-01

15 B. HICROPHONES............... ... .. ..... ....... 16 C. PREAMPLIFIER /FILTER ................. o....... 16 D. PHASE SHIFrER...Photgraphs ......................... 31 5. Microphone Specifications ........................... 32 6. Preamplifier /Filter Schematic...33 7. Preamplifier /Filter Printel Cir-cait Board ........... 34 8. Phase Shifter Schemitic ............................. 35 9. Phase Shifter Print.l

Comparative proteome analysis of laboratory grown Brucella abortus 2308 and Brucella melitensis 16M.

PubMed

Eschenbrenner, Michel; Horn, Troy A; Wagner, Mary Ann; Mujer, Cesar V; Miller-Scandle, Tabbi L; DelVecchio, Vito G

2006-07-01

Brucella species are pathogenic agents that cause brucellosis, a debilitating zoonotic disease that affects a large variety of domesticated animals and humans. Brucella melitensis and Brucella abortus are considered major health threats because of their highly infectious nature and worldwide occurrence. The availability of the annotated genomes for these two species has allowed a comparative proteomics study of laboratory grown B. melitensis 16M and B. abortus 2308 by two-dimensional (2-D) gel electrophoresis and peptide mass fingerprinting. Computer-assisted analysis of the different 2-D gel images of strains 16M and 2308 revealed significant quantitative and qualitative differences in their protein expression patterns. Proteins involved in membrane transport, particularly the high affinity amino acids binding proteins, and those involved in Sec-dependent secretion systems related to type IV and type V secretion systems, were differentially expressed. Differential expression of these proteins may be responsible for conferring specific host preference in the two strains 2308 and 16M.

AHF: Array-Based Half-Facet Data Structure for Mixed-Dimensional and Non-manifold Meshes

DTIC Science & Technology

2013-10-13

19a. NAME OF RESPONSIBLE PERSON 19b. TELEPHONE NUMBER James Glimm V. Dyedov, N. Ray, D. Einstein , X. Jiao, T.J. Tautges 611102 c. THIS PAGE The...Ray, D. Einstein , X. Jiao, and T. Tautges mesh data structures. Examples of such new demanding applications include coupled multiphysics simulations and...be composed of a union of topologically 1-D, 2-D, 4 V. Dyedov, N. Ray, D. Einstein , X. Jiao, and T. Tautges and 3-D objects, such as a mixture of