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Sample records for exceptionally common major

  1. Evidence for RNA editing in mitochondria of all major groups of land plants except the Bryophyta.

    PubMed Central

    Hiesel, R; Combettes, B; Brennicke, A

    1994-01-01

    RNA editing has been documented in mitochondria of higher plants, notably dicots and monocots. To determine the distribution of mitochondrial RNA editing in the plant kingdom, we have now undertaken a survey of evolutionarily distant plants. RNA editing occurs in all major groups of land plants except the Bryophyta, suggesting that this process is an ancient trait that was established before the radiation of kormophyte plants. No editing is observed in representatives of the green algae, suggesting that editing arose in early land plants after the split of the Bryophyta or has been lost selectively in both algae and mosses. In ferns several U-->C changes are observed, one of which eliminates a genomically encoded UAA termination codon and creates a functional open reading frame. Images Fig. 2 PMID:8290575

  2. Exceptional longevity and exceptionally high metabolic rates in anthropoid primates are linked to a major modification of the ubiquinone reduction site of cytochrome b.

    PubMed

    Rottenberg, Hagai

    2014-10-01

    The maximal lifespan of Anthropoid primates (monkeys, apes and humans) exceed the lifespan of most other mammals of equal body mass. Unexpectedly, their exceptional longevity is associated with exceptionally high metabolic rates, in apparent contradiction to the Free Radical Theory of Aging. It was therefore suggested that in anthropoid primates (and several other taxa of mammals and birds) the mitochondrial electron transport complexes evolved to modify the relationship between basal electron transport and superoxide generation to allow for the evolution of exceptional longevity. Cytochrome b, the core protein of the bc1 complex is a major source of superoxide. The amino-acid sequence of cytochrome b evolved much faster in anthropoid than in prosimian primates, and most other mammals, resulting in a large change in the amino-acids composition of the protein. As a result of these changes cytochrome b in anthropoid primates is significantly less hydrophobic and contains more polar residues than other primates and most other mammals. Most of these changes are clustered around the reduction site of uboiquinone. In particular a key positively charged residue, arginine 313, that interacts with propionate D of heme bH, and thus raises its redox potential, is substituted in anthropoid primates with the neutral residue glutamine, most likely resulting in a lower redox potential of heme bH and faster reduction of ubiquinone at high proton motive force. It is suggested that these changes contribute to the observed increased rates of basal metabolism and reduce the rates of superoxide production, thus allowing for increased lifespan.

  3. Common Genetic Variants on 6q24 Associated With Exceptional Episodic Memory Performance in the Elderly

    PubMed Central

    Barral, Sandra; Cosentino, Stephanie; Christensen, Kaare; Newman, Anne B.; Perls, Thomas T.; Province, Michael A.; Mayeux, Richard

    2015-01-01

    IMPORTANCE There aregenetic influences on memory ability as we age. but no specific genes have been identified. OBJECTIVE To use a cognitive endophenotype. exceptional episodic memory(EEM) performance. derived from nondemented offspring from the Long Life FamilyStudy(LLFS) to identify genetic variants that may be responsible for the high cognitive performance of LLFS participants and further replicate these variants using an additional 4006 nondemented individuals from 4 independent elderly cohorts DESIGN, SETTING, AND PARTICIPANTS A total of 467 LLFS participants from 18 families with 2 or more offspring that exhibited exceptional memory performance were used for genome-wide linkage analysis Adjusted multivariate linear analyses in the 40-megabase region encompassing the linkage peak were conducted using 4 independent replication data sets that included 4006 nondemented elderly individuals. Results of the individual replication cohorts were combined by meta-analysis MAIN OUTCOME MEASURE Episodic memory scores computed as the mean of the 2 standardized measures of Logical Memory IA and IIA RESULTS Heritability estimates indicated a significant genetic component for E EM (h2 = 0.21; SE = 0.09) Genome-wide linkage analysis revealed that EEM was linked to the 6q24 region (maximum logarithm of odds score, 3.64) Association analysis in LLFS families identified single-nucleotide polymorphisms (SNPs) nominally associated with EEM in the 40-megabase window encompassing the linkage peak Replication in one cohort identified a set of 26 SNPs associated with episodic memory (P ≤ 05) Meta-analysis of the 26 SNPs using the 4 independent replication cohorts found SN Ps rs9321334 and rs6902875 to be nominally significantly associated with episodic memory (P= .009 and P = .013. respectively). With meta-analysis restricted to individuals lacking an APOE ε4 allele. SNP rs6902875 became statistically significant (meta-analysis. P = 6.7 × 10−5) Haplotypeanalysis incorporating the

  4. Exceptionally preserved North American Paleogene metatherians: adaptations and discovery of a major gap in the opossum fossil record.

    PubMed

    Sánchez-Villagra, Marcelo; Ladevèze, Sandrine; Horovitz, Inés; Argot, Christine; Hooker, Jeremy J; Macrini, Thomas E; Martin, Thomas; Moore-Fay, Scott; de Muizon, Christian; Schmelzle, Thomas; Asher, Robert J

    2007-06-22

    A major gap in our knowledge of the evolution of marsupial mammals concerns the Paleogene of the northern continents, a critical time and place to link the early history of metatherians in Asia and North America with the more recent diversification in South America and Australia. We studied new exceptionally well-preserved partial skeletons of the Early Oligocene fossil Herpetotherium from the White River Formation in Wyoming, which allowed us to test the relationships of this taxon and examine its adaptations. Herpetotheriidae, with a fossil record extending from the Cretaceous to the Miocene, has traditionally been allied with opossums (Didelphidae) based on fragmentary material, mainly dentitions. Analysis of the new material reveals that several aspects of the cranial and postcranial anatomy, some of which suggests a terrestrial lifestyle, distinguish Herpetotherium from opossums. We found that Herpetotherium is the sister group to the crown group Marsupialia and is not a stem didelphid. Combination of the new palaeontological data with molecular divergence estimates, suggests the presence of a long undocumented gap in the fossil record of opossums extending some 45Myr from the Early Miocene to the Cretaceous.

  5. Common and contrasting genomic profiles among the major human lung cancer subtypes.

    PubMed

    Tonon, G; Brennan, C; Protopopov, A; Maulik, G; Feng, B; Zhang, Y; Khatry, D B; You, M J; Aguirre, A J; Martin, E S; Yang, Z; Ji, H; Chin, L; Wong, K-K; Depinho, R A

    2005-01-01

    Lung cancer is the leading cause of cancer mortality worldwide. With the recent success of molecularly targeted therapies in this disease, a detailed knowledge of the spectrum of genetic lesions in lung cancer represents a critical step in the development of additional effective agents. An integrated high-resolution survey of regional amplifications and deletions and gene expression profiling of non-small-cell lung cancers (NSCLC) identified 93 focal high-confidence copy number alterations (CNAs), with 21 spanning less than 0.5 Mb with a median of five genes. Most CNAs were novel and included high-amplitude amplification and homozygous deletion events. Pathogenic relevance of these genomic alterations was further reinforced by their recurrence and overlap with focal alterations of other tumor types. Additionally, the comparison of the genomic profiles of the two major subtypes of NSCLC, adenocarcinoma (AC) and squamous cell carcinoma (SCC), showed an almost complete overlap with the exception of one amplified region on chromosome 3, specific for SCC. Among the few genes overexpressed within this amplicon was p63, a known regulator of squamous cell differentiation. These findings suggest that the AC and SCC subtypes may arise from a common cell of origin and they are driven to their distinct phenotypic end points by altered expression of a limited number of key genes such as p63.

  6. A major Pseudomonas aeruginosa clone common to patients and aquatic habitats.

    PubMed Central

    Römling, U; Wingender, J; Müller, H; Tümmler, B

    1994-01-01

    The genomic relatedness of 573 Pseudomonas aeruginosa strains from environmental and clinical habitats was examined by digesting the genome with the rare-cutting enzyme SpeI. Thirty-nine strains were collected from environmental habitats mainly of aquatic origin, like rivers, lakes, or sanitary facilities. Four hundred fifty strains were collected from 76 patients with cystic fibrosis (CF) treated at four different centers, and 25 additional clinical isolates were collected from patients suffering from other diseases. Twenty-nine P. aeruginosa isolates were collected from the environment of one CF clinic. Thirty strains from culture collections were of environmental and clinic origin. A common macrorestriction fingerprint pattern was found in 13 of 46 CF patients, 5 of 29 environmental isolates from the same hospital, in a single ear infection isolate from another hospital, and 8 of 38 isolates from aquatic habitats about 300 km away from the CF clinic. The data indicate that closely related variants of one major clone (called clone C) persisted in various spatially and temporally separated habitats. Southern analysis of the clonal variants with six gene probes and two probes for genes coding for rRNA revealed almost the same hybridization patterns. With the exception of the phenotypically rapidly evolving CF isolates, the close relatedness of the strains of the clone was also shown by their identical responses in pyocin typing, phage typing, and serotyping. Besides clone C, three other P. aeruginosa clones were isolated from more than one clinical or environmental source. Images PMID:8031075

  7. Exceptional Students: Exceptional Needs.

    ERIC Educational Resources Information Center

    Burt, Marilyn; And Others

    The purpose of this investigation was to determine the needs and problems of exceptional middle school students as well as their perceptions of guidance services. Participants in the study were 229 educable mentally-retarded (EMR) and 245 gifted (GIF) students in six Alachua County (Florida) middle schools. The racial distribution of the students…

  8. Common Genetic and Environmental Influences on Major Depressive Disorder and Conduct Disorder

    ERIC Educational Resources Information Center

    Subbarao, Anjali; Rhee, Soo Hyun; Young, Susan E.; Ehringer, Marissa A.; Corley, Robin P.; Hewitt, John K.

    2008-01-01

    The evidence for common genetic and environmental influences on conduct disorder (CD) and major depressive disorder (MDD) in adolescents was examined. A sample of 570 monozygotic twin pairs, 592 dizygotic twin pairs, and 426 non-twin siblings, aged 12-18 years, was recruited from the Colorado Twin Registry. For the past year data, there was a…

  9. Exceptionally High Representation of Burkholderia cepacia among B. cepacia Complex Isolates Recovered from the Major Portuguese Cystic Fibrosis Center▿

    PubMed Central

    Cunha, Mónica V.; Pinto-de-Oliveira, Ana; Meirinhos-Soares, Luís; Salgado, Maria José; Melo-Cristino, José; Correia, Susana; Barreto, Celeste; Sá-Correia, Isabel

    2007-01-01

    Burkholderia cepacia, a species found infrequently in cystic fibrosis (CF), was isolated from 85% of patients infected with bacteria of the B. cepacia complex that visited the major Portuguese CF center, in Lisbon, during 2003 to 2005. A detailed molecular analysis revealed that this was mainly due to two B. cepacia clones. These clones were indistinguishable from two strains isolated from intrinsically contaminated nonsterile saline solutions for nasal application, detected during routine market surveillance by the Portuguese Medicines and Health Products Authority. PMID:17360834

  10. Exceptions to the rules of oil-spill behavior: Case studies of major oil spills of the past twenty years

    SciTech Connect

    Hayes, M.O.

    1994-11-01

    Studies of major oil spills over the past 20 yr have allowed an evolution of our understanding of how to respond to and remediate the environmental impacts from such spills. There have been a number of spills for which follow-up research has provided major turning points that allowed the development of certain rules of oil-spill behavior. For example, the spill of over 100,000 tons of crude oil by the tanker Urquiola on the coast of Spain in May 1976 demonstrated the importance of hydrodynamic energy level in natural cleanup processes. Research on the spill of over 200,000 tons of crude oil along the coast of France by the tanker Amoco Cadiz in March 1978 allowed a better understanding of the long-term effects of spilled oil on exposed tidal flats and salt marshes. The oil spilled by the tanker Exxon Valdez in Prince William Sound, Alaska, in March 1989 impacted many miles of gravel beaches, which were treated by a number of methods, including some innovative berm-relocation techniques. A thorough understanding of the coastal geomorphology and processes of the spill site was essential for the development of meaningful contingency and response plans. Research on the impacts of intertidal habitats of the coast of Saudi Arabia during the Gulf War spill of 1991 indicates that some previously held concepts on oil behavior and fate on shorelines must be revised. One of the best established rules of oil-spill behavior was that the depth of oil penetration on sand beaches and tidal flats increases with increasing sediment grain size. However, no such correlation was found on the Saudi Arabian coast, primarily due to the presence of secondary porosity (e.g., bubble sand, extensive burrows, and gypsum crystals). The oil penetrated to depths of tens of centimeters, even in fine sand, which has significantly slowed natural removal processes and weathering rates. These sediments remained heavily oiled with incipient asphalt pavements forming two years after the spill.

  11. Feto-maternal HLA compatibility does not have a major influence on human pregnancy except for lymphocytotoxin production.

    PubMed Central

    Jazwinska, E C; Kilpatrick, D C; Smart, G E; Liston, W A

    1987-01-01

    Several studies have supported the hypothesis that the maternal immune response to incompatible paternal HLA antigens present on the conceptus may influence pregnancy outcome. In order to relate feto-maternal histocompatibility directly to pregnancy course and characteristics, complete HLA-A, B and DR types were obtained from 132 healthy family groups consisting of mothers, fathers and neonates. The distribution of feto-maternal HLA compatibility was heavily skewed towards incompatibility, with 90% of fetuses being mismatched at 2 or 3 loci. There was no segregation distortion of paternal haplotypes, however, and the number of feto-maternal mismatches was close to that expected theoretically. More than 2% of the neonates were perfectly HLA-A, B and DR compatible with their mothers. The degree of feto-maternal HLA disparity showed no significant correlation with sex of neonate, birthweight, placental weight, maternal plasma alpha-fetoprotein or parity of the mother. Feto-maternal HLA disparity did, however, correlate significantly with maternal lymphocytotoxin production, even after allowance was made for parity (P less than 0.01). We conclude that feto-maternal HLA compatibility per se does not have a major influence on pregnancy outcome, and in particular is unlikely to predispose to spontaneous abortion; so an absence of antigen sharing between spouses experiencing recurrent spontaneous abortions should not be regarded in itself as a contraindication to offering immunotherapy to such couples. PMID:3477351

  12. Resilience to major life stressors is not as common as thought

    PubMed Central

    Infurna, Frank J.; Luthar, Suniya S.

    2015-01-01

    We attempted to replicate findings that “most people are resilient” following three events: spousal loss, divorce, and unemployment. We applied growth mixture models to the same longitudinal data set that has previously been used to assert that resilience is ubiquitous. When using identical model specifications as in prior studies, we found that resilient trajectories were most common, but the number of trajectories identified was different. When we relaxed the assumptions that (a) all classes have similar variability in levels of post-adversity adjustment and (b) there is no variability in changes within classes (as in prior studies), we found that a resilience class was least common. Methodologically, our results demonstrate how findings on trajectories of change following major life stressors vary substantially depending on statistical model specifications. Conceptually, they underscore the errors inherent in any categorical statements about “rates of resilience” among individuals confronted with major life stressors. Pragmatically, they underscore the dangers in recommending against prophylactic interventions -- based on one method of analyzing longitudinal data -- for individuals who have experienced major life stressors. PMID:26993272

  13. Common volatiles are major attractants for neonate larvae of the specialist flea beetle Altica koreana (Coleoptera: Chrysomelidae)

    NASA Astrophysics Data System (ADS)

    Xue, Huai-Jun; Yang, Xing-Ke

    2008-07-01

    Olfactory stimuli play an important role in the host searching of larval phytophagous insects. Previous studies indicate that larvae that have to find feeding sites after hatching are generally attracted to host volatiles. However, there are few studies on the olfactory responses of neonate larvae to host volatiles in cases when those larvae hatched on the host plant. In the present study, we determined the olfactory responses of neonate larvae of the specialist flea beetle, Altica koreana Ogloblin, to host and six non-host plants, using a static-air “arena.” Larvae responded significantly to the host plant Potentilla chinensis Ser. and five of six non-host plants, compared to the control. Larvae did not prefer the host plant over the non-host plants (except Artemisia sp.) when offered a choice. Additionally, odours of a non-host plant, which were unattractive to neonate larvae, may have masked the attractive odour of the host plant. These results indicate that common volatiles can play a major role in attracting larvae of this specialist to plants, but attraction to such odours may not be the major mechanism of host choice.

  14. Neuroinformatic analyses of common and distinct genetic components associated with major neuropsychiatric disorders.

    PubMed

    Lotan, Amit; Fenckova, Michaela; Bralten, Janita; Alttoa, Aet; Dixson, Luanna; Williams, Robert W; van der Voet, Monique

    2014-01-01

    Major neuropsychiatric disorders are highly heritable, with mounting evidence suggesting that these disorders share overlapping sets of molecular and cellular underpinnings. In the current article we systematically test the degree of genetic commonality across six major neuropsychiatric disorders-attention deficit hyperactivity disorder (ADHD), anxiety disorders (Anx), autistic spectrum disorders (ASD), bipolar disorder (BD), major depressive disorder (MDD), and schizophrenia (SCZ). We curated a well-vetted list of genes based on large-scale human genetic studies based on the NHGRI catalog of published genome-wide association studies (GWAS). A total of 180 genes were accepted into the analysis on the basis of low but liberal GWAS p-values (<10(-5)). 22% of genes overlapped two or more disorders. The most widely shared subset of genes-common to five of six disorders-included ANK3, AS3MT, CACNA1C, CACNB2, CNNM2, CSMD1, DPCR1, ITIH3, NT5C2, PPP1R11, SYNE1, TCF4, TENM4, TRIM26, and ZNRD1. Using a suite of neuroinformatic resources, we showed that many of the shared genes are implicated in the postsynaptic density (PSD), expressed in immune tissues and co-expressed in developing human brain. Using a translational cross-species approach, we detected two distinct genetic components that were both shared by each of the six disorders; the 1st component is involved in CNS development, neural projections and synaptic transmission, while the 2nd is implicated in various cytoplasmic organelles and cellular processes. Combined, these genetic components account for 20-30% of the genetic load. The remaining risk is conferred by distinct, disorder-specific variants. Our systematic comparative analysis of shared and unique genetic factors highlights key gene sets and molecular processes that may ultimately translate into improved diagnosis and treatment of these debilitating disorders.

  15. Neuroinformatic analyses of common and distinct genetic components associated with major neuropsychiatric disorders

    PubMed Central

    Lotan, Amit; Fenckova, Michaela; Bralten, Janita; Alttoa, Aet; Dixson, Luanna; Williams, Robert W.; van der Voet, Monique

    2014-01-01

    Major neuropsychiatric disorders are highly heritable, with mounting evidence suggesting that these disorders share overlapping sets of molecular and cellular underpinnings. In the current article we systematically test the degree of genetic commonality across six major neuropsychiatric disorders—attention deficit hyperactivity disorder (ADHD), anxiety disorders (Anx), autistic spectrum disorders (ASD), bipolar disorder (BD), major depressive disorder (MDD), and schizophrenia (SCZ). We curated a well-vetted list of genes based on large-scale human genetic studies based on the NHGRI catalog of published genome-wide association studies (GWAS). A total of 180 genes were accepted into the analysis on the basis of low but liberal GWAS p-values (<10−5). 22% of genes overlapped two or more disorders. The most widely shared subset of genes—common to five of six disorders–included ANK3, AS3MT, CACNA1C, CACNB2, CNNM2, CSMD1, DPCR1, ITIH3, NT5C2, PPP1R11, SYNE1, TCF4, TENM4, TRIM26, and ZNRD1. Using a suite of neuroinformatic resources, we showed that many of the shared genes are implicated in the postsynaptic density (PSD), expressed in immune tissues and co-expressed in developing human brain. Using a translational cross-species approach, we detected two distinct genetic components that were both shared by each of the six disorders; the 1st component is involved in CNS development, neural projections and synaptic transmission, while the 2nd is implicated in various cytoplasmic organelles and cellular processes. Combined, these genetic components account for 20–30% of the genetic load. The remaining risk is conferred by distinct, disorder-specific variants. Our systematic comparative analysis of shared and unique genetic factors highlights key gene sets and molecular processes that may ultimately translate into improved diagnosis and treatment of these debilitating disorders. PMID:25414627

  16. Distinctive and common neural underpinnings of major depression, social anxiety, and their comorbidity.

    PubMed

    Hamilton, J Paul; Chen, Michael C; Waugh, Christian E; Joormann, Jutta; Gotlib, Ian H

    2015-04-01

    Assessing neural commonalities and differences among depression, anxiety and their comorbidity is critical in developing a more integrative clinical neuroscience and in evaluating currently debated categorical vs dimensional approaches to psychiatric classification. Therefore, in this study, we sought to identify patterns of anomalous neural responding to criticism and praise that are specific to and common among major depressive disorder (MDD), social anxiety disorder (SAD) and comorbid MDD-SAD. Adult females who met formal diagnostic criteria for MDD, SAD or MDD-SAD and psychiatrically healthy participants underwent functional magnetic resonance imaging as they listened to statements directing praise or criticism at them or at another person. MDD groups showed reduced responding to praise across a distributed cortical network, an effect potentially mediated by thalamic nuclei undergirding arousal-mediated attention. SAD groups showed heightened anterior insula and decreased default-mode network response to criticism. The MDD-SAD group uniquely showed reduced responding to praise in the dorsal anterior cingulate cortex. Finally, all groups with psychopathology showed heightened response to criticism in a region of the superior frontal gyrus implicated in attentional gating. The present results suggest novel neural models of anhedonia in MDD, vigilance-withdrawal behaviors in SAD, and poorer outcome in MDD-SAD. Importantly, in identifying unique and common neural substrates of MDD and SAD, these results support a formulation in which common neural components represent general risk factors for psychopathology that, due to factors that are present at illness onset, lead to distinct forms of psychopathology with unique neural signatures. © The Author (2014). Published by Oxford University Press. For Permissions, please email: journals.permissions@oup.com.

  17. A Next Generation Air Monitor: Combining Orion and ISS Requirements for a Common Major Constituent Analyzer

    NASA Technical Reports Server (NTRS)

    Burchfield, David E.; Tissandier, Michael; Niu, William Hsein-Chi; Lewis, John F.

    2013-01-01

    The Major Constituent Analyzer (MCA) is a mass spectrometer-based instrument designed to provide critical monitoring of six major atmospheric constituents; nitrogen, oxygen, hydrogen, carbon dioxide, methane, and water vapor on-board the International Space Station. The analyzer has been an integral part of the Environmental Control and Life Support System (ECLSS) since the station went on-line. The Orion Air Monitor (OAM) was derived from the MCA and heavily optimized for reduced mass, lower power, faster water vapor response, and maintenance-free operation. The resulting OAM is approximately the size of the analyzer portion of the MCA, orbital-replacement unit 02 (ORU 02), while incorporating the functions of three other modules: Data Processing and Communication (ORU 01), Verification Gas Assembly (ORU 08), and Low Voltage Power Supply (ORU 04). The overlap in MCA and OAM requirements makes it possible to derive a common Air Monitor design that spans both applications while minimally impacting the weight and power limits imposed by the Multipurpose Crew Vehicle (MPCV). Benefits to ISS include the retirement of ORUs 01, 04, and 08, reducing up-mass and eliminating EEE parts obsolescence issues through the extended ISS mission phases. Benefits to MPCV and future deployed habitats under the Constellation program include greater interchangeability across ECLSS subsystems. This paper discusses the results of the requirements development study, where a superset of ISS and Orion air monitoring requirements were distilled; evaluated against increases in OAM functionality, mass, and power; and traded-off where possible using simple operating mode modifications. A system architecture and preliminary design addressing the common requirements will be presented.

  18. A Next Generation Air Monitor: Combining Orion and ISS Requirements for a Common Major Constituent Analyzer

    NASA Technical Reports Server (NTRS)

    Burchfield, David E.; Tissandier, Michael; Niu, William Hsein-Chi; Lewis, John F.

    2013-01-01

    The Major Constituent Analyzer (MCA) is a mass spectrometer-based instrument designed to provide critical monitoring of six major atmospheric constituents; nitrogen, oxygen, hydrogen, carbon dioxide, methane, and water vapor on-board the International Space Station. The analyzer has been an integral part of the Environmental Control and Life Support System (ECLSS) since the station went on-line. The Orion Air Monitor (OAM) was derived from the MCA and heavily optimized for reduced mass, lower power, faster water vapor response, and maintenance-free operation. The resulting OAM is approximately the size of the analyzer portion of the MCA, orbital-replacement unit 02 (ORU 02), while incorporating the functions of three other modules: Data Processing and Communication (ORU 01), Verification Gas Assembly (ORU 08), and Low Voltage Power Supply (ORU 04). The overlap in MCA and OAM requirements makes it possible to derive a common Air Monitor design that spans both applications while minimally impacting the weight and power limits imposed by the Multipurpose Crew Vehicle (MPCV). Benefits to ISS include the retirement of ORUs 01, 04, and 08, reducing up-mass and eliminating EEE parts obsolescence issues through the extended ISS mission phases. Benefits to MPCV and future deployed habitats under the Constellation program include greater interchangeability across ECLSS subsystems. This paper discusses the results of the requirements development study, where a superset of ISS and Orion air monitoring requirements were distilled; evaluated against increases in OAM functionality, mass, and power; and traded-off where possible using simple operating mode modifications. A system architecture and preliminary design addressing the common requirements will be presented.

  19. HLA-DR and HLA-DP genotypes and immunoglobulin E responses to common major allergens.

    PubMed

    Young, R P; Dekker, J W; Wordsworth, B P; Schou, C; Pile, K D; Matthiesen, F; Rosenberg, W M; Bell, J I; Hopkin, J M; Cookson, W O

    1994-05-01

    In order to test for human histocompatibility leucocyte antigens (HLA) class II restriction of IgE responses, 431 subjects from 83 families were genotyped at the HLA-DR and HLA-DP loci and serotyped for IgE responses to six major allergens from common aero-allergen sources. A possible excess of HLA-DR1 was found in subjects who were responsive to Fel d I compared with those who were not (Odds Ratio (OR) = 2, P = 0.002), and a possible excess of HLA-DR4 was found in subjects responsive to Alt a I (OR = 1.9, P = 0.006). Increased sharing of HLA-DR/DP haplotypes was seen in sibling pairs responding to both allergens. Der p I, Der p II, Phl p V and Can f I were not associated with any definite excess of HLA-DR alleles. No significant correlations were seen with HLA-DP genotype and reactivity to any of the allergens. The results suggest class II HLA restriction is insufficient to account for individual differences in reactivity to common allergens.

  20. Outsourcing of common industry data within a major oil and gas exploration company

    SciTech Connect

    Hude, C.G. ); Glover, S. )

    1993-09-01

    Enhancing user productivity while reducing internal costs through improved accessibility and virtual elimination of data and software maintenance were the initial goals of this project. We achieved these objectives through the outsourcing of common well and production data with a major vendor. In this paper, we outline the changing internal business operations of a major oil company and its associated vendor relationship. The goals of this project were multifold: provide our users with real-time access to nationwide well and production data, eliminate data and system software maintenance and support, redeploy computer system resources and personnel for use elsewhere within the organization, and continue to provide users with the same level of service at less cost. We established a satisfactory interface between the users and the vendor database by employing existing technology. A mainframe-to-mainframe connection was established by installing a leased line between the two host sites. This allowed both companies to use existing network facilities with minimal modifications to each operating environment. This project was begun successfully in a relatively short time. Due to the success of this project, we are evaluating adding company proprietary data. However, because technology and requirements change, relational delivery of the data within a workstation/server environment can be addressed within this framework.

  1. Abnormal functional brain asymmetry in depression: evidence of biologic commonality between major depression and dysthymia.

    PubMed

    Bruder, Gerard E; Stewart, Jonathan W; Hellerstein, David; Alvarenga, Jorge E; Alschuler, Daniel; McGrath, Patrick J

    2012-04-30

    Prior studies have found abnormalities of functional brain asymmetry in patients having a major depressive disorder (MDD). This study aimed to replicate findings of reduced right hemisphere advantage for perceiving dichotic complex tones in depressed patients, and to determine whether patients having "pure" dysthymia show the same abnormality of perceptual asymmetry as MDD. It also examined gender differences in lateralization, and the extent to which abnormalities of perceptual asymmetry in depressed patients are dependent on gender. Unmedicated patients having either a MDD (n=96) or "pure" dysthymic disorder (n=42) and healthy controls (n=114) were tested on dichotic fused-words and complex-tone tests. Patient and control groups differed in right hemisphere advantage for complex tones, but not left hemisphere advantage for words. Reduced right hemisphere advantage for tones was equally present in MDD and dysthymia, but was more evident among depressed men than depressed women. Also, healthy men had greater hemispheric asymmetry than healthy women for both words and tones, whereas this gender difference was not seen for depressed patients. Dysthymia and MDD share a common abnormality of hemispheric asymmetry for dichotic listening.

  2. "We Are in This Together": Common Group Identity Predicts Majority Members' Active Acculturation Efforts to Integrate Immigrants.

    PubMed

    Kunst, Jonas R; Thomsen, Lotte; Sam, David L; Berry, John W

    2015-10-01

    Although integration involves a process of mutual accommodation, the role of majority groups is often downplayed to passive tolerance, leaving immigrants with the sole responsibility for active integration. However, we show that common group identity can actively involve majority members in this process across five studies. Study 1 showed that common identity positively predicted support of integration efforts; Studies 2 and 3 extended these findings, showing that it also predicted real behavior such as monetary donations and volunteering. A decrease in modern racism mediated the relations across these studies, and Studies 4 and 5 further demonstrated that it indeed mediated these effects over and above acculturation expectations and color-blindness, which somewhat compromised integration efforts. Moreover, the last two studies also demonstrated that common, but not dual, groups motivated integration efforts. Common identity appears crucial for securing majorities' altruistic efforts to integrate immigrants and, thus, for achieving functional multiculturalism.

  3. Commonality.

    ERIC Educational Resources Information Center

    Beaton, Albert E., Jr.

    Commonality analysis is an attempt to understand the relative predictive power of the regressor variables, both individually and in combination. The squared multiple correlation is broken up into elements assigned to each individual regressor and to each possible combination of regressors. The elements have the property that the appropriate sums…

  4. Common genetic variants, acting additively, are a major source of risk for autism

    PubMed Central

    2012-01-01

    Background Autism spectrum disorders (ASD) are early onset neurodevelopmental syndromes typified by impairments in reciprocal social interaction and communication, accompanied by restricted and repetitive behaviors. While rare and especially de novo genetic variation are known to affect liability, whether common genetic polymorphism plays a substantial role is an open question and the relative contribution of genes and environment is contentious. It is probable that the relative contributions of rare and common variation, as well as environment, differs between ASD families having only a single affected individual (simplex) versus multiplex families who have two or more affected individuals. Methods By using quantitative genetics techniques and the contrast of ASD subjects to controls, we estimate what portion of liability can be explained by additive genetic effects, known as narrow-sense heritability. We evaluate relatives of ASD subjects using the same methods to evaluate the assumptions of the additive model and partition families by simplex/multiplex status to determine how heritability changes with status. Results By analyzing common variation throughout the genome, we show that common genetic polymorphism exerts substantial additive genetic effects on ASD liability and that simplex/multiplex family status has an impact on the identified composition of that risk. As a fraction of the total variation in liability, the estimated narrow-sense heritability exceeds 60% for ASD individuals from multiplex families and is approximately 40% for simplex families. By analyzing parents, unaffected siblings and alleles not transmitted from parents to their affected children, we conclude that the data for simplex ASD families follow the expectation for additive models closely. The data from multiplex families deviate somewhat from an additive model, possibly due to parental assortative mating. Conclusions Our results, when viewed in the context of results from genome

  5. The Major Field Test in Business: A Direct Measure of Learning in Common Business Disciplines

    ERIC Educational Resources Information Center

    Simmons, Susan A.; Jones, Wesley M., Jr; Bolt, Cynthia E.

    2015-01-01

    Assurance of learning and its assessment are critical focal points in collegiate schools of business as programs strive to achieve or maintain Association to Advance Collegiate Schools of Business accreditation. Prior research suggests that student learning in business core disciplines can be measured by the Educational Testing Service Major Field…

  6. The Major Field Test in Business: A Direct Measure of Learning in Common Business Disciplines

    ERIC Educational Resources Information Center

    Simmons, Susan A.; Jones, Wesley M., Jr; Bolt, Cynthia E.

    2015-01-01

    Assurance of learning and its assessment are critical focal points in collegiate schools of business as programs strive to achieve or maintain Association to Advance Collegiate Schools of Business accreditation. Prior research suggests that student learning in business core disciplines can be measured by the Educational Testing Service Major Field…

  7. No major role of common SV2A variation for predisposition or levetiracetam response in epilepsy.

    PubMed

    Lynch, J M; Tate, S K; Kinirons, P; Weale, M E; Cavalleri, G L; Depondt, C; Murphy, K; O'Rourke, D; Doherty, C P; Shianna, K V; Wood, N W; Sander, J W; Delanty, N; Goldstein, D B; Sisodiya, S M

    2009-01-01

    Levetiracetam (LEV), a newer antiepileptic drug (AED) useful for several epilepsy syndromes, binds to SV2A. Identifying genetic variants that influence response to LEV may allow more tailored use of LEV. Obvious candidate genes are SV2A, SV2B and SV2C, which encode the only known binding site, synaptic vesicle protein 2 (SV2), with LEV binding to the SV2A isoform. SV2A is an essential protein as homozygous SV2A knockout mice appear normal at birth but fail to grow, experience severe seizures and die by 3 weeks. We addressed characterising AED response issues in pharmacogenetics and whether variation in these genes associates with response to LEV in two independent cohorts with epilepsy. We also investigated whether variation in these three genes associated with epilepsy predisposition in two larger cohorts of patients with various epilepsy phenotypes. Common genetic variation in SV2A, encoding the actual binding site of LEV, was fully represented in this study whereas SV2B and SV2C were not fully covered. None of the polymorphisms tested in SV2A, SV2B or SV2C influence LEV response or predisposition to epilepsy. We found no association between genetic variation in SV2A, SV2B or SV2C and response to LEV or epilepsy predisposition. We suggest this study design may be used in future pharmacogenetic work examining AED or LEV efficacy. However, different study designs would be needed to examine common variation with minor effect sizes, or rare variation, influencing AED or LEV response or epilepsy predisposition.

  8. Problematic Internet use was more common in Turkish adolescents with major depressive disorders than controls.

    PubMed

    Alpaslan, Ahmet Hamdi; Soylu, Nusret; Kocak, Ugur; Guzel, Halil Ibrahim

    2016-06-01

    This study compared problematic Internet use (PIU) rates in 12- to 18-year-olds with major depressive disorder (MDD) and healthy controls and explored potential links between PIU and suicide among patients with MDD. The study sample consisted of 120 patients with MDD (62.5% girls) and 100 controls (58% girls) with a mean age of 15. Suicide ideation and suicide attempts were evaluated, and sociodemographic data were collected. In addition, the Children's Depression Inventory, Young Internet Addiction Test and Suicide Probability Scale were applied. The results showed that PIU rates were significantly higher in the MDD cases than the controls (p < 0.001). The analysis of covariance results showed that there was no relationship between potential suicide and the Young Internet Addiction Test score in MDD cases. However, the hopelessness subscale scores of the MDD patients with PIU were significantly higher than the scores of those without PIU. Our results show that PIU was higher in adolescents with MDD and hopelessness was more prevalent among MDD patients with PIU, but no links with potential suicide were found. As this study was a cross-sectional one, it did not allow us to infer a causality relationship between PIU and MDD. ©2016 Foundation Acta Paediatrica. Published by John Wiley & Sons Ltd.

  9. Major histocompatibility complex based resistance to a common bacterial pathogen of amphibians.

    PubMed

    Barribeau, Seth M; Villinger, Jandouwe; Waldman, Bruce

    2008-07-16

    Given their well-developed systems of innate and adaptive immunity, global population declines of amphibians are particularly perplexing. To investigate the role of the major histocompatibility complex (MHC) in conferring pathogen resistance, we challenged Xenopus laevis tadpoles bearing different combinations of four MHC haplotypes (f, g, j, and r) with the bacterial pathogen Aeromonas hydrophila in two experiments. In the first, we exposed ff, fg, gg, gj, and jj tadpoles, obtained from breeding MHC homozygous parents, to one of three doses of A. hydrophila or heat-killed bacteria as a control. In the second, we exposed ff, fg, fr, gg, rg, and rr tadpoles, obtained from breeding MHC heterozygous parents and subsequently genotyped by PCR, to A. hydrophila, heat-killed bacteria or media alone as controls. We thereby determined whether the same patterns of MHC resistance emerged within as among families, independent of non-MHC heritable differences. Tadpoles with r or g MHC haplotypes were more likely to die than were those with f or j haplotypes. Growth rates varied among MHC types, independent of exposure dose. Heterozygous individuals with both susceptible and resistant haplotypes were intermediate to either homozygous genotype in both size and survival. The effect of the MHC on growth and survival was consistent between experiments and across families. MHC alleles differentially confer resistance to, or tolerance of, the bacterial pathogen, which affects tadpoles' growth and survival.

  10. Major Histocompatibility Complex Based Resistance to a Common Bacterial Pathogen of Amphibians

    PubMed Central

    Barribeau, Seth M.; Villinger, Jandouwe; Waldman, Bruce

    2008-01-01

    Given their well-developed systems of innate and adaptive immunity, global population declines of amphibians are particularly perplexing. To investigate the role of the major histocompatibilty complex (MHC) in conferring pathogen resistance, we challenged Xenopus laevis tadpoles bearing different combinations of four MHC haplotypes (f, g, j, and r) with the bacterial pathogen Aeromonas hydrophila in two experiments. In the first, we exposed ff, fg, gg, gj, and jj tadpoles, obtained from breeding MHC homozygous parents, to one of three doses of A. hydrophila or heat-killed bacteria as a control. In the second, we exposed ff, fg, fr, gg, rg, and rr tadpoles, obtained from breeding MHC heterozygous parents and subsequently genotyped by PCR, to A. hydrophila, heat-killed bacteria or media alone as controls. We thereby determined whether the same patterns of MHC resistance emerged within as among families, independent of non-MHC heritable differences. Tadpoles with r or g MHC haplotypes were more likely to die than were those with f or j haplotypes. Growth rates varied among MHC types, independent of exposure dose. Heterozygous individuals with both susceptible and resistant haplotypes were intermediate to either homozygous genotype in both size and survival. The effect of the MHC on growth and survival was consistent between experiments and across families. MHC alleles differentially confer resistance to, or tolerance of, the bacterial pathogen, which affects tadpoles' growth and survival. PMID:18629002

  11. The 52 symptoms of major depression: Lack of content overlap among seven common depression scales.

    PubMed

    Fried, Eiko I

    2017-01-15

    Depression severity is assessed in numerous research disciplines, ranging from the social sciences to genetics, and used as a dependent variable, predictor, covariate, or to enroll participants. The routine practice is to assess depression severity with one particular depression scale, and draw conclusions about depression in general, relying on the assumption that scales are interchangeable measures of depression. The present paper investigates to which degree 7 common depression scales differ in their item content and generalizability. A content analysis is carried out to determine symptom overlap among the 7 scales via the Jaccard index (0=no overlap, 1=full overlap). Per scale, rates of idiosyncratic symptoms, and rates of specific vs. compound symptoms, are computed. The 7 instruments encompass 52 disparate symptoms. Mean overlap among all scales is low (0.36), mean overlap of each scale with all others ranges from 0.27 to 0.40, overlap among individual scales from 0.26 to 0.61. Symptoms feature across a mean of 3 scales, 40% of the symptoms appear in only a single scale, 12% across all instruments. Scales differ regarding their rates of idiosyncratic symptoms (0-33%) and compound symptoms (22-90%). Future studies analyzing more and different scales will be required to obtain a better estimate of the number of depression symptoms; the present content analysis was carried out conservatively and likely underestimates heterogeneity across the 7 scales. The substantial heterogeneity of the depressive syndrome and low overlap among scales may lead to research results idiosyncratic to particular scales used, posing a threat to the replicability and generalizability of depression research. Implications and future research opportunities are discussed. Copyright © 2016 Elsevier B.V. All rights reserved.

  12. Major histocompatibility complex variation in red wolves: evidence for common ancestry with coyotes and balancing selection.

    PubMed

    Hedrick, P W; Lee, R N; Garrigan, D

    2002-10-01

    We examined variation at a class II major histocompatibility complex (MHC) gene (DRB1) in the captive red wolf population and samples of coyotes from Texas and North Carolina. We found 4 alleles in the 48 red wolves, 8 alleles in the 10 coyotes from Texas and 15 alleles in the 29 coyotes from North Carolina. Two of the four alleles found in red wolves, Caru-2 and Caru-4, were found in both the Texas and North Carolina coyote samples. Allele Caru-1, previously found in gray wolves, was also found in the North Carolina sample. The most frequent red wolf allele, Caru-3, was not found in any of the coyote samples. However, an allele found in both the Texas and North Carolina coyote samples is only one nucleotide (one amino acid) different from this red wolf allele. Overall, it appears from examination of this MHC gene that red wolves are more closely related to coyotes than to gray wolves. There were a number of different types of evidence supporting the action of balancing selection in red wolves. Namely, there was: (i) an excess of heterozygotes compared with expectations; (ii) a higher rate of nonsynonymous than synonymous substitution for the functionally important antigen-binding site positions; (iii) an eight times higher average heterozygosity of individual amino acids at the positions identified as part of the antigen-binding site than those not associated with it; (iv) the amino acid divergence of four red wolf alleles was greater than that expected from a simulation of genetic drift; and (v) the distribution of alleles, and the distributions of amino acids at many positions were more even than expected from neutrality. Examination of the level and pattern of linkage disequilibria between pairs of sites suggest that the heterozygosity, substitution and frequencies at individual amino acids are not highly dependent upon each other.

  13. Exceptional Stars

    NASA Astrophysics Data System (ADS)

    Kulkarni, S. R.; Hansen, B.; van Kerkwijk, M.; Phinney, E. S.

    2005-12-01

    As part of our Interdisciplinary Scientist effort (PI, Kulkarni) for the Space Interferometry Mission (SIM) we proposed an investigation with SIM of a number of exceptional stars. With SIM we plan to observe dozens of nearby white dwarfs and search for planets surviving the evolution away from the main sequence as well as (newly formed) planets formed in the circumbinary disks of post-AGB binaries or as a result of white dwarf mergers. We propose to measure the proper motion of a sample of X-ray binaries and Be star binaries with the view of understanding the originof high latitude objects and inferring natal kicks and pre-supernova orbits. We plan to observe several compact object binaries to determine the mass of the compact star. Of particular importance is the proposed observation of SS 433 (for which we propose to use the spectrometer on SIM to measure the proper motion of the emission line clumps embedded in the relativistic jets). Separately we are investigating the issue of frame tie between SIM and the ecliptic frame (by observing binary millisecond pulsars with SIM; the position of these objects is very well determined by pulsar timing) and the degree to which highly precise visibility amplitude measurements can be inverted to infer binary parameters.

  14. Structure of genetic diversity in the two major gene pools of common bean (Phaseolus vulgaris L., Fabaceae).

    PubMed

    Kwak, Myounghai; Gepts, Paul

    2009-03-01

    Domesticated materials with well-known wild relatives provide an experimental system to reveal how human selection during cultivation affects genetic composition and adaptation to novel environments. In this paper, our goal was to elucidate how two geographically distinct domestication events modified the structure and level of genetic diversity in common bean. Specifically, we analyzed the genome-wide genetic composition at 26, mostly unlinked microsatellite loci in 349 accessions of wild and domesticated common bean from the Andean and Mesoamerican gene pools. Using a model-based approach, implemented in the software STRUCTURE, we identified nine wild or domesticated populations in common bean, including four of Andean and four of Mesoamerican origins. The ninth population was the putative wild ancestor of the species, which was classified as a Mesoamerican population. A neighbor-joining analysis and a principal coordinate analysis confirmed genetic relationships among accessions and populations observed with the STRUCTURE analysis. Geographic and genetic distances in wild populations were congruent with the exception of a few putative hybrids identified in this study, suggesting a predominant effect of isolation by distance. Domesticated common bean populations possessed lower genetic diversity, higher F(ST), and generally higher linkage disequilibrium (LD) than wild populations in both gene pools; their geographic distributions were less correlated with genetic distance, probably reflecting seed-based gene flow after domestication. The LD was reduced when analyzed in separate Andean and Mesoamerican germplasm samples. The Andean domesticated race Nueva Granada had the highest F(ST) value and widest geographic distribution compared to other domesticated races, suggesting a very recent origin or a selection event, presumably associated with a determinate growth habit, which predominates in this race.

  15. Exceptional Parent, 1993.

    ERIC Educational Resources Information Center

    Klein, Stanley D., Ed.

    1993-01-01

    This document consists of the nine issues of the journal "Exceptional Parent" published during 1993. This journal contains articles particularly aimed at parents of children with disabilities. Major articles published during this period are the following: "Annual Guide to Products and Services"; "Coping with Incontinence" (Katherine F. Jeter);…

  16. Exceptional production of both prodigiosin and cycloprodigiosin as major metabolic constituents by a novel marine bacterium, Zooshikella rubidus S1-1.

    PubMed

    Lee, Jong Suk; Kim, Yong-Sook; Park, Sooyeon; Kim, Jihoon; Kang, So-Jung; Lee, Mi-Hwa; Ryu, Sangryeol; Choi, Jong Myoung; Oh, Tae-Kwang; Yoon, Jung-Hoon

    2011-07-01

    A Gram-negative, red-pigment-producing marine bacterial strain, designated S1-1, was isolated from the tidal flat sediment of the Yellow Sea, Korea. On the basis of phenotypic, phylogenetic, and genetic data, strain S1-1 (KCTC 11448BP) represented a new species of the genus Zooshikella. Thus, we propose the name Zooshikella rubidus sp. nov. Liquid chromatography and mass spectrometry of the red pigments produced by strain S1-1 revealed that the major metabolic compounds were prodigiosin and cycloprodigiosin. In addition, this organism produced six minor prodigiosin analogues, including two new structures that were previously unknown. To our knowledge, this is the first description of a microorganism that simultaneously produces prodigiosin and cycloprodigiosin as two major metabolites. Both prodigiosin and cycloprodigiosin showed antimicrobial activity against several microbial species. These bacteria were approximately 1.5-fold more sensitive to cycloprodigiosin than to prodigiosin. The metabolites also showed anticancer activity against human melanoma cells, which showed significantly more sensitivity to prodigiosin than to cycloprodigiosin. The secondary metabolite profiles of strain S1-1 and two reference bacterial strains were compared by liquid chromatography-mass spectrometry. Multivariate statistical analyses based on secondary metabolite profiles by liquid chromatography-mass spectrometry indicated that the metabolite profile of strain S1-1 could clearly be distinguished from those of two phylogenetically related, prodigiosin-producing bacterial strains.

  17. Exceptional Production of both Prodigiosin and Cycloprodigiosin as Major Metabolic Constituents by a Novel Marine Bacterium, Zooshikella rubidus S1-1 ▿ †

    PubMed Central

    Lee, Jong Suk; Kim, Yong-Sook; Park, Sooyeon; Kim, Jihoon; Kang, So-Jung; Lee, Mi-Hwa; Ryu, Sangryeol; Choi, Jong Myoung; Oh, Tae-Kwang; Yoon, Jung-Hoon

    2011-01-01

    A Gram-negative, red-pigment-producing marine bacterial strain, designated S1-1, was isolated from the tidal flat sediment of the Yellow Sea, Korea. On the basis of phenotypic, phylogenetic, and genetic data, strain S1-1 (KCTC 11448BP) represented a new species of the genus Zooshikella. Thus, we propose the name Zooshikella rubidus sp. nov. Liquid chromatography and mass spectrometry of the red pigments produced by strain S1-1 revealed that the major metabolic compounds were prodigiosin and cycloprodigiosin. In addition, this organism produced six minor prodigiosin analogues, including two new structures that were previously unknown. To our knowledge, this is the first description of a microorganism that simultaneously produces prodigiosin and cycloprodigiosin as two major metabolites. Both prodigiosin and cycloprodigiosin showed antimicrobial activity against several microbial species. These bacteria were approximately 1.5-fold more sensitive to cycloprodigiosin than to prodigiosin. The metabolites also showed anticancer activity against human melanoma cells, which showed significantly more sensitivity to prodigiosin than to cycloprodigiosin. The secondary metabolite profiles of strain S1-1 and two reference bacterial strains were compared by liquid chromatography-mass spectrometry. Multivariate statistical analyses based on secondary metabolite profiles by liquid chromatography-mass spectrometry indicated that the metabolite profile of strain S1-1 could clearly be distinguished from those of two phylogenetically related, prodigiosin-producing bacterial strains. PMID:21642414

  18. Identification, quantification, spatiotemporal distribution and genetic variation of major latex secondary metabolites in the common dandelion (Taraxacum officinale agg.).

    PubMed

    Huber, Meret; Triebwasser-Freese, Daniella; Reichelt, Michael; Heiling, Sven; Paetz, Christian; Chandran, Jima N; Bartram, Stefan; Schneider, Bernd; Gershenzon, Jonathan; Erb, Matthias

    2015-07-01

    The secondary metabolites in the roots, leaves and flowers of the common dandelion (Taraxacum officinale agg.) have been studied in detail. However, little is known about the specific constituents of the plant's highly specialized laticifer cells. Using a combination of liquid and gas chromatography, mass spectrometry and nuclear magnetic resonance spectrometry, we identified and quantified the major secondary metabolites in the latex of different organs across different growth stages in three genotypes, and tested the activity of the metabolites against the generalist root herbivore Diabrotica balteata. We found that common dandelion latex is dominated by three classes of secondary metabolites: phenolic inositol esters (PIEs), triterpene acetates (TritAc) and the sesquiterpene lactone taraxinic acid β-D-glucopyranosyl ester (TA-G). Purification and absolute quantification revealed concentrations in the upper mgg(-1) range for all compound classes with up to 6% PIEs, 5% TritAc and 7% TA-G per gram latex fresh weight. Contrary to typical secondary metabolite patterns, concentrations of all three classes increased with plant age. The highest concentrations were measured in the main root. PIE profiles differed both quantitatively and qualitatively between plant genotypes, whereas TritAc and TA-G differed only quantitatively. Metabolite concentrations were positively correlated within and between the different compound classes, indicating tight biosynthetic co-regulation. Latex metabolite extracts strongly repelled D. balteata larvae, suggesting that the latex constituents are biologically active. Copyright © 2015 Elsevier Ltd. All rights reserved.

  19. Expanding upon the 'extreme male brain' theory of autism as a common link between other major risk factors: a hypothesis.

    PubMed

    Wen, Wendy; Wen, Shi Wu

    2014-05-01

    On average, males have a stronger preference for physical systems and machines over interpersonal interactions; they have lower average levels of cognitive empathy or social cognition than females; and they have higher rates of 'extreme' intelligence when it comes to abstract concepts such as those found in mathematics and sciences. All three traits are also commonly associated with individuals with an autism spectrum disorder or ASD; clearly, it is not coincidental that incidence rates of autism are reportedly four times higher in males than in females. The common link between the majority of risk factors assessed in this review (including technological advancements, advanced parental age, socioeconomic status, and genetic predispositions towards ASDs in families of scientists and engineers) can be traced to a specific hormone, testosterone. It was established that traits which are typically associated with males are also typically associated with ASDs as well as individuals with antisocial personality disorder, or APD. The key distinction between individuals who are considered to be 'autistic' as opposed to those who are considered 'sociopathic' lies in the difference between their empathy deficits: whereas those who are 'autistic' are said to lack cognitive empathy (the ability to identify and understand the thoughts and feelings of others and to respond to these with appropriate emotions), those who are 'sociopathic' are said to lack emotional empathy (which is responsible for inhibiting acts of physical aggression or violence). This would explain why autistic individuals can have elevated testosterone levels without becoming physically aggressive.

  20. The majority of enteroaggregative Escherichia coli strains produce the E. coli common pilus when adhering to cultured epithelial cells.

    PubMed

    Avelino, Fabiola; Saldaña, Zeus; Islam, Sohidul; Monteiro-Neto, Valerio; Dall'Agnol, Monique; Eslava, Carlos A; Girón, Jorge A

    2010-11-01

    Enteroaggregative Escherichia coli (EAEC) have emerged as a significant worldwide cause of chronic diarrhea in the pediatric population and in HIV patients. The vast majority of EAEC strains do not produce the aggregative adherence fimbriae I-III (AAFs) so far reported and thus, what adherence factors are present in these strains remains unknown. Here, we investigated the prevalence of the chromosomal E. coli common pilus (ECP) genes and ECP production amongst 130 EAEC strains of diverse origin as well as the role of ECP in EAEC adherence. Through multiplex PCR analysis we found that 96% of EAEC strains contained the ecpA structural pilin gene whereas only 3.1% and 5.4% were positive for AAF fimbrial genes aggA or aafA, respectively. Among the ecpA(+) strains, 63% produced ECP when adhering to cultured epithelial cells. An ecpA mutant derived from prototypic strain 042 (AAF/II(+)) was not altered in adherence suggesting that the AAF/II, and not ECP, plays a major role in this strain. In contrast, strain 278-1 (AAF(-)) deleted of the ecpA gene was significantly reduced in adherence to cultured epithelial cells. In all, these data indicate a potential role of ECP in adherence for EAEC strains lacking the known AAFs and that in association with other adhesive determinants, ECP may contribute to their survival and persistence within the host and in the environment.

  1. A Comparative Analyses of Granulometry, Mineral Composition and Major and Trace Element Concentrations in Soils Commonly Ingested by Humans

    PubMed Central

    Ngole-Jeme, Veronica M.; Ekosse, Georges-Ivo E.

    2015-01-01

    This study compared the granulometric properties, mineralogical composition and concentrations of major and trace element oxides of commonly ingested soils (geophagic soil) collected from different countries with a view of understanding how varied they may be in these properties and to understand the possible health implications of ingesting them. Soil samples were collected from three different countries (South Africa, Swaziland and Democratic Republic of Congo (DRC)) and their granulometric properties, concentrations of major and trace element oxides as well as mineralogical composition determined. Differences were observed in the granulometric properties of geophagic soil from the three different countries with most of them having <20% clay content. The soils also showed varied degrees of weathering with values of Chemical Index of Alteration (CIA) and Chemical Index of Weathering (CIW) being between 60% and 99.9% respectively. The mineral assemblages of the soils from South Africa and Swaziland were dominated by the primary minerals quartz and feldspar whereas soils from DRC had more of kaolinite, a secondary mineral than primary minerals. Soils from DRC were associated with silt, clay, Al2O3, and CIA unlike most samples from South Africa which were associated with SiO2, sand, K2O, CaO, and MgO. The soils from Swaziland were closely associated with silt, H2O and Fe2O3(t). These associations reflect the mineralogy of the samples. These soils are not likely to serve as nutrient supplements because of the low concentrations of the nutrient elements contained. The coarse texture of the samples may also result in dental destruction during mastication. Sieving of the soils before ingestion to remove coarse particles is recommended to reduce the potential health threat associated with the ingestion of coarse-textured soils. PMID:26264010

  2. A Comparative Analyses of Granulometry, Mineral Composition and Major and Trace Element Concentrations in Soils Commonly Ingested by Humans.

    PubMed

    Ngole-Jeme, Veronica M; Ekosse, Georges-Ivo E

    2015-07-31

    This study compared the granulometric properties, mineralogical composition and concentrations of major and trace element oxides of commonly ingested soils (geophagic soil) collected from different countries with a view of understanding how varied they may be in these properties and to understand the possible health implications of ingesting them. Soil samples were collected from three different countries (South Africa, Swaziland and Democratic Republic of Congo (DRC)) and their granulometric properties, concentrations of major and trace element oxides as well as mineralogical composition determined. Differences were observed in the granulometric properties of geophagic soil from the three different countries with most of them having <20% clay content. The soils also showed varied degrees of weathering with values of Chemical Index of Alteration (CIA) and Chemical Index of Weathering (CIW) being between 60% and 99.9% respectively. The mineral assemblages of the soils from South Africa and Swaziland were dominated by the primary minerals quartz and feldspar whereas soils from DRC had more of kaolinite, a secondary mineral than primary minerals. Soils from DRC were associated with silt, clay, Al2O3, and CIA unlike most samples from South Africa which were associated with SiO2, sand, K2O, CaO, and MgO. The soils from Swaziland were closely associated with silt, H2O and Fe2O3(t). These associations reflect the mineralogy of the samples. These soils are not likely to serve as nutrient supplements because of the low concentrations of the nutrient elements contained. The coarse texture of the samples may also result in dental destruction during mastication. Sieving of the soils before ingestion to remove coarse particles is recommended to reduce the potential health threat associated with the ingestion of coarse-textured soils.

  3. Amino Acid Variation in HLA Class II Proteins Is a Major Determinant of Humoral Response to Common Viruses

    PubMed Central

    Hammer, Christian; Begemann, Martin; McLaren, Paul J.; Bartha, István; Michel, Angelika; Klose, Beate; Schmitt, Corinna; Waterboer, Tim; Pawlita, Michael; Schulz, Thomas F.; Ehrenreich, Hannelore; Fellay, Jacques

    2015-01-01

    The magnitude of the human antibody response to viral antigens is highly variable. To explore the human genetic contribution to this variability, we performed genome-wide association studies of the immunoglobulin G response to 14 pathogenic viruses in 2,363 immunocompetent adults. Significant associations were observed in the major histocompatibility complex region on chromosome 6 for influenza A virus, Epstein-Barr virus, JC polyomavirus, and Merkel cell polyomavirus. Using local imputation and fine mapping, we identified specific amino acid residues in human leucocyte antigen (HLA) class II proteins as the most probable causal variants underlying these association signals. Common HLA-DRβ1 haplotypes showed virus-specific patterns of humoral-response regulation. We observed an overlap between variants affecting the humoral response to influenza A and EBV and variants previously associated with autoimmune diseases related to these viruses. The results of this study emphasize the central and pathogen-specific role of HLA class II variation in the modulation of humoral immune response to viral antigens in humans. PMID:26456283

  4. Simultaneous determination of major phytocannabinoids, their main metabolites, and common synthetic cannabinoids in urine samples by LC-MS/MS.

    PubMed

    Dong, Xiaoru; Li, Liliang; Ye, Yonghong; Zheng, Lixing; Jiang, Yan

    2016-10-15

    Simultaneous determination of major phytocannabinoids (THC, CBD, CBN), their main metabolites (11-OH-THC, THC-COOH, THC-COOH-glucuronide) and common synthetic cannabinoids (HU-210, JWH-018, JWH-073, JWH-250) remains an issue in forensic toxicology. The present study has developed a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method to simultaneously detect the above 10 analytes in human urine samples. The chromatographic separation was performed on an ACQUITY UPLC(®)BEH Phenyl 1.7μm (2.1×100mm) column, using a mobile phase consisting of 0.1% formic acid in water and acetonitrile at a flow rate of 0.3mL/min in gradient elution mode. The limit of detection (LOD) and limit of quantification (LOQ) of all analytes were 0.01-0.5ng/mL and 0.05-1ng/mL, respectively. The assay was linear from LOQ to 100ng/mL for phytocannabinoids, their main metabolites and HU-210, and from 0.05 to 50ng/mL for JWH-250, JWH-018 and JWH-073. The extraction recoveries were over 50% and the matrix effects were between 59.4% and 100.1%. The accuracy and precision were <10.4% of bias and <10.5% of relative standard deviation (RSD), respectively. The developed method was applied to 5 urine samples from real caseworks, and the results that THC metabolites together with synthetic cannabinoids were detected demonstrated the effectiveness of our method.

  5. Autophagy competes for a common phosphatidylethanolamine pool with major cellular PE-consuming pathways in Saccharomyces cerevisiae.

    PubMed

    Wilson-Zbinden, Caroline; dos Santos, Aline Xavier da Silveira; Stoffel-Studer, Ingrid; van der Vaart, Aniek; Hofmann, Kay; Reggiori, Fulvio; Riezman, Howard; Kraft, Claudine; Peter, Matthias

    2015-02-01

    Autophagy is a highly regulated pathway that selectively degrades cellular constituents such as protein aggregates and excessive or damaged organelles. This transport route is characterized by engulfment of the targeted cargo by autophagosomes. The formation of these double-membrane vesicles requires the covalent conjugation of the ubiquitin-like protein Atg8 to phosphatidylethanolamine (PE). However, the origin of PE and the regulation of lipid flux required for autophagy remain poorly understood. Using a genetic screen, we found that the temperature-sensitive growth and intracellular membrane organization defects of mcd4-174 and mcd4-P301L mutants are suppressed by deletion of essential autophagy genes such as ATG1 or ATG7. MCD4 encodes an ethanolamine phosphate transferase that uses PE as a precursor for an essential step in the synthesis of the glycosylphosphatidylinositol (GPI) anchor used to link a subset of plasma membrane proteins to lipid bilayers. Similar to the deletion of CHO2, a gene encoding the enzyme converting PE to phosphatidylcholine (PC), deletion of ATG7 was able to restore lipidation and plasma membrane localization of the GPI-anchored protein Gas1 and normal organization of intracellular membranes. Conversely, overexpression of Cho2 was lethal in mcd4-174 cells grown at restrictive temperature. Quantitative lipid analysis revealed that PE levels are substantially reduced in the mcd4-174 mutant but can be restored by deletion of ATG7 or CHO2. Taken together, these data suggest that autophagy competes for a common PE pool with major cellular PE-consuming pathways such as the GPI anchor and PC synthesis, highlighting the possible interplay between these pathways and the existence of signals that may coordinate PE flux.

  6. Sensitization to common allergens among patients with allergies in major Iranian cities: a systematic review and meta-analysis.

    PubMed

    Moghtaderi, Mozhgan; Hosseini Teshnizi, Saeed; Farjadian, Shirin

    2017-01-01

    Various allergens are implicated in the pathogenesis of allergic diseases in different regions. This study attempted to identify the most common allergens among patients with allergies based on the results of skin prick tests in different parts of Iran. Relevant studies conducted from 2000 to 2016 were identified from the MEDLINE database. Six common groups of allergen types, including animal, cockroach, food, fungus, house dust mite, and pollen were considered. Subgroup analysis was performed to determine the prevalence of each type of allergen. The Egger test was used to assess publication bias. We included 44 studies in this meta-analysis. The overall prevalence of positive skin test results for at least one allergen was estimated to be 59% in patients with allergies in various parts of Iran. The number of patients was 11,646 (56% male and 44% female), with a mean age of 17.46±11.12 years. The most common allergen sources were pollen (47.0%), mites (35.2%), and food (15.3%). The prevalence of sensitization to food and cockroach allergens among children was greater than among adults. Pollen is the most common allergen sensitization in cities of Iran with a warm and dry climate; however, sensitization to house dust mites is predominant in northern and southern coastal areas of Iran.

  7. Bacterial components are the major contributors to the macrophage stimulating activity exhibited by extracts of common edible mushrooms

    USDA-ARS?s Scientific Manuscript database

    Background: Recent studies have indicated that a major contributor to the innate immune enhancing properties of some medicinal plants derive from the cell wall components of bacteria colonizing these plants. Purpose: The purpose of the current study was to assess if the bacteria present within edib...

  8. Bacterial components are the major contributors to the macrophage stimulating activity exhibited by extracts of common edible mushrooms

    USDA-ARS?s Scientific Manuscript database

    Background: Recent studies have indicated that a major contributor to the innate immune enhancing properties of some medicinal plants is derived from the cell wall components of bacteria colonizing these plants. Purpose: The purpose of the current study was to assess if the bacteria present withi...

  9. Exceptionality in vowel harmony

    NASA Astrophysics Data System (ADS)

    Szeredi, Daniel

    Vowel harmony has been of great interest in phonological research. It has been widely accepted that vowel harmony is a phonetically natural phenomenon, which means that it is a common pattern because it provides advantages to the speaker in articulation and to the listener in perception. Exceptional patterns proved to be a challenge to the phonetically grounded analysis as they, by their nature, introduce phonetically disadvantageous sequences to the surface form, that consist of harmonically different vowels. Such forms are found, for example in the Finnish stem tuoli 'chair' or in the Hungarian suffixed form hi:d-hoz 'to the bridge', both word forms containing a mix of front and back vowels. There has recently been evidence shown that there might be a phonetic level explanation for some exceptional patterns, as the possibility that some vowels participating in irregular stems (like the vowel [i] in the Hungarian stem hi:d 'bridge' above) differ in some small phonetic detail from vowels in regular stems. The main question has not been raised, though: does this phonetic detail matter for speakers? Would they use these minor differences when they have to categorize a new word as regular or irregular? A different recent trend in explaining morphophonological exceptionality by looking at the phonotactic regularities characteristic of classes of stems based on their morphological behavior. Studies have shown that speakers are aware of these regularities, and use them as cues when they have to decide what class a novel stem belongs to. These sublexical phonotactic regularities have already been shown to be present in some exceptional patterns vowel harmony, but many questions remain open: how is learning the static generalization linked to learning the allomorph selection facet of vowel harmony? How much does the effect of consonants on vowel harmony matter, when compared to the effect of vowel-to-vowel correspondences? This dissertation aims to test these two ideas

  10. Major correlates of mercury in small fish and common loons (Gavia immer) across four large study areas in Canada.

    PubMed

    Scheuhammer, A M; Lord, S I; Wayland, M; Burgess, N M; Champoux, L; Elliott, J E

    2016-03-01

    We investigated mercury (Hg) concentrations in small fish (mainly yellow perch, Perca flavescens; ∼60% of fish collected) and in blood of common loons (Gavia immer) that prey upon them during the breeding season on lakes in 4 large, widely separated study areas in Canada (>13 lakes per study area; total number of lakes = 93). Although surface sediments from lakes near a base metal smelter in Flin Flon, Manitoba had the highest Hg concentrations, perch and other small fish and blood of common loon chicks sampled from these same lakes had low Hg concentrations similar to those from uncontaminated reference lakes. Multiple regression modeling with AIC analysis indicated that lake pH was by far the most important single factor influencing perch Hg concentrations in lakes across the four study areas (R(2) = 0.29). The best model was a three-variable model (pH + alkalinity + sediment Se; Wi = 0.61, R(2) = 0.85). A single-variable model (fish Hg) best explained among-lake variability in loon chick blood Hg (Wi = 0.17; R(2) = 0.53). From a toxicological risk perspective, all lakes posing a potential Hg health risk for perch and possibly other small pelagic fish species (where mean fish muscle Hg concentrations exceeded 2.4 μg/g dry wt.), and for breeding common loons (where mean fish muscle Hg concentrations exceeded 0.8 μg/g dry wt., and loon chick blood Hg exceeded 1.4 μg/g dry wt.) had pH < 6.7 and were located in eastern Canada.

  11. Mosaic segmental uniparental isodisomy and progressive clonal selection: a common mechanism of late onset β-thalassemia major

    PubMed Central

    Harteveld, Cornelis L.; Refaldi, Chiara; Giambona, Antonino; Ruivenkamp, Claudia A. L.; Hoffer, Mariëtte J. V.; Pijpe, Jeroen; De Knijff, Peter; Borgna-Pignatti, Caterina; Maggio, Aurelio; Cappellini, Maria D.; Giordano, Piero C.

    2013-01-01

    Genomic DNA of 3 patients, born as healthy carriers and developing a late-onset severe transfusion-dependent beta-thalassemia major was studied by high-density genome wide SNP array analysis. A mosaic loss of heterozygosity for almost the entire 11p was found, not attributable to deletions but involving mosaicism for segmental paternal isodisomy of 11p. Mitotic recombination leading to mosaic segmental uniparental isodisomy on chromosome 11p in multiple tissues has been described as a molecular disease mechanism for a subset of sporadic Beckwith-Wiedemann syndrome cases. A similar mechanism also seems to be involved in causing late-onset disease in carriers of recessive mutations in other genes located in 11p, such as late-onset beta-thalassemia major and sickle cell disease. We suggest that the loss of maternally imprinted IGF-2 and H19 genes may account for the selective advantage of hematopoietic cells containing this segmental paternal isodisomy of 11p carrying the β-thalassemia mutation. PMID:22983591

  12. Common variants in FKBP5 gene and major depressive disorder (MDD) susceptibility: a comprehensive meta-analysis

    PubMed Central

    Rao, Shuquan; Yao, Yao; Ryan, Joanne; Li, Tao; Wang, Duan; Zheng, Chuan; Xu, Yong; Xu, Qi

    2016-01-01

    Previous studies have investigated the association between common variants in FKBP5 and MDD; however, the results remain inconsistent. In order to conduct a comprehensive meta-analysis of the association between FKBP5 variants and MDD risk, seven studies involving 26582 subjects, including 12491 cases with MDD and 14091 controls, were enrolled totally. Four common SNPs (rs1360780, rs4713916, rs3800373 and rs755658) with complete data from two or more studies were analyzed. In the total sample, there was no evidence of a significant association between MDD and any of the four SNPs using a random-effects model. However, after removing one heterogeneous German study, as indicated by sensitivity analysis, both the rs1360780 T-allele (Z = 2.95, P = 0.003, OR = 1.06, 95% CI = 1.02–1.11) and the rs3800373 C-allele (Z = 3.05, P = 0.002, OR = 1.07, 95% CI 1.02–1.12) were significantly associated with MDD in a fixed-effect model. Our study thus provides support for an association between specific FKBP5 genetic variants and MDD risk. Rs4713916 was not significantly associated with MDD; However, this analysis had limited statistical power and larger sample sizes are required to further validate this result. Future research should also investigate possible gender- and ethnicity-specific differences in the association between FKBP5 and MDD. PMID:27601205

  13. Exceptional Responders Initial Feasibility Results

    Cancer.gov

    A pilot study evaluating identification of cancer patients who respond to treatment that is ineffective in at least 90 percent of patients found that it was indeed able to confirm a majority of proposed patients as exceptional responders based on clinical

  14. Use of a pig model to demonstrate vulnerability of major neck vessels to inflicted trauma from common household items.

    PubMed

    Byard, Roger W; Cains, Glenda E; Gilbert, John D

    2007-03-01

    Commonly available items including a ball point pen, a plastic knife, a broken wine bottle, and a broken wine glass were used to inflict stab and incised wounds to the necks of 3 previously euthanized Large White pigs. With relative ease, these items could be inserted into the necks of the pigs next to the jugular veins and carotid arteries. Despite precautions against the carrying of metal objects such as knives and nail files on board domestic and international flights, objects are still available within aircraft cabins that could be used to inflict serious and potentially life-threatening injuries. If airport and aircraft security measures are to be consistently applied, then consideration should be given to removing items such as glass bottles and glass drinking vessels. However, given the results of a relatively uncomplicated modification of a plastic knife, it may not be possible to remove all dangerous objects from aircraft. Security systems may therefore need to focus on measures such as increased surveillance of passenger behavior, rather than on attempting to eliminate every object that may serve as a potential weapon.

  15. Proton-dependent coniferin transport, a common major transport event in differentiating xylem tissue of woody plants.

    PubMed

    Tsuyama, Taku; Kawai, Ryo; Shitan, Nobukazu; Matoh, Toru; Sugiyama, Junji; Yoshinaga, Arata; Takabe, Keiji; Fujita, Minoru; Yazaki, Kazufumi

    2013-06-01

    Lignin biosynthesis is an essential physiological activity of vascular plants if they are to survive under various environmental stresses on land. The biosynthesis of lignin proceeds in the cell wall by polymerization of precursors; the initial step of lignin polymerization is the transportation of lignin monomers from the cytosol to the cell wall, which is critical for lignin formation. There has been much debate on the transported form of the lignin precursor, either as free monolignols or their glucosides. In this study, we performed biochemical analyses to characterize the membrane transport mechanism of lignin precursors using angiosperms, hybrid poplar (Populus sieboldii × Populus grandidentata) and poplar (Populus sieboldii), as well gymnosperms, Japanese cypress (Chamaecyparis obtusa) and pine (Pinus densiflora). Membrane vesicles prepared from differentiating xylem tissues showed clear ATP-dependent transport activity of coniferin, whereas less than 4% of the coniferin transport activity was seen for coniferyl alcohol. Bafilomycin A1 and proton gradient erasers markedly inhibited coniferin transport in hybrid poplar membrane vesicles; in contrast, vanadate had no effect. Cis-inhibition experiments suggested that this transport activity was specific for coniferin. Membrane fractionation of hybrid poplar microsomes demonstrated that transport activity was localized to the tonoplast- and endomembrane-rich fraction. Differentiating xylem of Japanese cypress exhibited almost identical transport properties, suggesting the involvement of a common endomembrane-associated proton/coniferin antiport mechanism in the lignifying tissues of woody plants, both angiosperms and gymnosperms.

  16. Proton-Dependent Coniferin Transport, a Common Major Transport Event in Differentiating Xylem Tissue of Woody Plants1[W

    PubMed Central

    Tsuyama, Taku; Kawai, Ryo; Shitan, Nobukazu; Matoh, Toru; Sugiyama, Junji; Yoshinaga, Arata; Takabe, Keiji; Fujita, Minoru; Yazaki, Kazufumi

    2013-01-01

    Lignin biosynthesis is an essential physiological activity of vascular plants if they are to survive under various environmental stresses on land. The biosynthesis of lignin proceeds in the cell wall by polymerization of precursors; the initial step of lignin polymerization is the transportation of lignin monomers from the cytosol to the cell wall, which is critical for lignin formation. There has been much debate on the transported form of the lignin precursor, either as free monolignols or their glucosides. In this study, we performed biochemical analyses to characterize the membrane transport mechanism of lignin precursors using angiosperms, hybrid poplar (Populus sieboldii × Populus grandidentata) and poplar (Populus sieboldii), as well gymnosperms, Japanese cypress (Chamaecyparis obtusa) and pine (Pinus densiflora). Membrane vesicles prepared from differentiating xylem tissues showed clear ATP-dependent transport activity of coniferin, whereas less than 4% of the coniferin transport activity was seen for coniferyl alcohol. Bafilomycin A1 and proton gradient erasers markedly inhibited coniferin transport in hybrid poplar membrane vesicles; in contrast, vanadate had no effect. Cis-inhibition experiments suggested that this transport activity was specific for coniferin. Membrane fractionation of hybrid poplar microsomes demonstrated that transport activity was localized to the tonoplast- and endomembrane-rich fraction. Differentiating xylem of Japanese cypress exhibited almost identical transport properties, suggesting the involvement of a common endomembrane-associated proton/coniferin antiport mechanism in the lignifying tissues of woody plants, both angiosperms and gymnosperms. PMID:23585651

  17. SOS1 is the second most common Noonan gene but plays no major role in cardio‐facio‐cutaneous syndrome

    PubMed Central

    Zenker, Martin; Horn, Denise; Wieczorek, Dagmar; Allanson, Judith; Pauli, Silke; van der Burgt, Ineke; Doerr, Helmuth‐Guenther; Gaspar, Harald; Hofbeck, Michael; Gillessen‐Kaesbach, Gabriele; Koch, Andreas; Meinecke, Peter; Mundlos, Stefan; Nowka, Anja; Rauch, Anita; Reif, Silke; von Schnakenburg, Christian; Seidel, Heide; Wehner, Lars‐Erik; Zweier, Christiane; Bauhuber, Susanne; Matejas, Verena; Kratz, Christian P; Thomas, Christoph; Kutsche, Kerstin

    2007-01-01

    Background Heterozygous gain‐of‐function mutations in various genes encoding proteins of the Ras‐MAPK signalling cascade have been identified as the genetic basis of Noonan syndrome (NS) and cardio‐facio‐cutaneous syndrome (CFCS). Mutations of SOS1, the gene encoding a guanine nucleotide exchange factor for Ras, have been the most recent discoveries in patients with NS, but this gene has not been studied in patients with CFCS. Methods and results We investigated SOS1 in a large cohort of patients with disorders of the NS–CFCS spectrum, who had previously tested negative for mutations in PTPN11, KRAS, BRAF, MEK1 and MEK2. Missense mutations of SOS1 were discovered in 28% of patients with NS. In contrast, none of the patients classified as having CFCS was found to carry a pathogenic sequence change in this gene. Conclusion We have confirmed SOS1 as the second major gene for NS. Patients carrying mutations in this gene have a distinctive phenotype with frequent ectodermal anomalies such as keratosis pilaris and curly hair. However, the clinical picture associated with SOS1 mutations is different from that of CFCS. These findings corroborate that, despite being caused by gain‐of‐function mutations in molecules belonging to the same pathway, NS and CFCS scarcely overlap genotypically. PMID:17586837

  18. SYNE1 ataxia is a common recessive ataxia with major non-cerebellar features: a large multi-centre study.

    PubMed

    Synofzik, Matthis; Smets, Katrien; Mallaret, Martial; Di Bella, Daniela; Gallenmüller, Constanze; Baets, Jonathan; Schulze, Martin; Magri, Stefania; Sarto, Elisa; Mustafa, Mona; Deconinck, Tine; Haack, Tobias; Züchner, Stephan; Gonzalez, Michael; Timmann, Dagmar; Stendel, Claudia; Klopstock, Thomas; Durr, Alexandra; Tranchant, Christine; Sturm, Marc; Hamza, Wahiba; Nanetti, Lorenzo; Mariotti, Caterina; Koenig, Michel; Schöls, Ludger; Schüle, Rebecca; de Jonghe, Peter; Anheim, Mathieu; Taroni, Franco; Bauer, Peter

    2016-05-01

    , including premature death due to respiratory dysfunction. With a relative frequency of ∼5%, SYNE1 is one of the more common recessive ataxias worldwide.

  19. Common genetic variation in the indoleamine-2,3-dioxygenase genes and antidepressant treatment outcome in major depressive disorder.

    PubMed

    Cutler, Jessica A; Rush, A John; McMahon, Francis J; Laje, Gonzalo

    2012-03-01

    The essential amino acid tryptophan is the precursor to serotonin, but it can also be metabolized into kynurenine through indoleamine-2,3-dioxygenase (IDO). Increased immune activation has long been associated with symptoms of depression and has been shown to upregulate the expression of IDO. The presence of additional IDO directs more tryptophan down the kynurenine pathway, leaving less available for synthesis of serotonin and its metabolites. Kynurenine can be metabolized through a series of enzymes to quinolinic acid, a potent N-methyl-D-aspartate receptor agonist with demonstrated neurotoxic effects. We tested the hypothesis that IDO plays a role in outcome of treatment with the selective serotonin reuptake inhibitor, citalopram. Patients consisted of 1953 participants enrolled in the Sequenced Treatment Alternatives to Relieve Depression study (STAR*D). Genotypes corresponding to 94 single nucleotide polymorphisms (SNPs) in the genes IDO1 and IDO2, which encode IDO and IDO2, were extracted from a larger genome-wide set and analyzed using single marker tests to look for association with previously defined response, remission and QIDS-C score change phenotypes, with adequate correction for racial stratification and multiple testing. One SNP, rs2929115, showed evidence of association with citalopram response (OR = 0.64, p = 0.0005) after experiment-wide correction for multiple testing. Another closely associated marker, rs2929116 (OR = 0.64, p = 0.0006) had an experiment-wide significant result. Both implicated SNPs are located between 26 kb and 28 kb downstream of IDO2. We conclude that common genetic variation in IDO1 and IDO2 may play a role in antidepressant treatment outcome. These results are modest in a genome-wide context and need to be replicated in an independent sample.

  20. Bacterial components are the major contributors to the macrophage stimulating activity exhibited by extracts of common edible mushrooms.

    PubMed

    Tyler, Heather L; Haron, Mona H; Pugh, Nirmal D; Zhang, Jin; Jackson, Colin R; Pasco, David S

    2016-10-12

    Recent studies have indicated that a major contributor to the innate immune enhancing properties of some medicinal plants is derived from the cell wall components of bacteria colonizing these plants. The purpose of the current study was to assess if the bacteria present within edible and medicinal mushrooms substantially contribute to the innate immune stimulating potential of these mushrooms. Whole mushrooms from thirteen types of edible fungi and individual parts from Agaricus bisporus were analyzed for in vitro macrophage activation as well as bacterial lipopolysaccharides (LPS) content, cell load, and community composition. Substantial variation between samples was observed in macrophage activation (over 500-fold), total bacterial load (over 200-fold), and LPS content (over 10 million-fold). Both LPS content (ρ = 0.832, p < 0.0001) and total bacterial load (ρ = 0.701, p < 0.0001) correlated significantly with macrophage activation in the whole mushroom extracts. Extract activity was negated by treatment with NaOH, conditions that inactivate LPS and other bacterial components. Significant correlations between macrophage activation and total bacterial load (ρ = 0.723, p = 0.0001) and LPS content (ρ = 0.951, p < 0.0001) were also observed between different tissues of Agaricus bisporus. Pseudomonas and Flavobacterium were the most prevalent genera identified in the different tissue parts and these taxa were significantly correlated with in vitro macrophage activation (ρ = 0.697, p < 0.0001 and ρ = 0.659, p = 0.0001, respectively). These results indicate that components derived from mushroom associated bacteria contribute substantially to the innate immune enhancing activity exhibited by mushrooms and may result in similar therapeutic actions as reported for ingestion of bacterial preparations such as probiotics.

  1. An Exceptional Memory

    ERIC Educational Resources Information Center

    Hunter, Ian M. L.

    1977-01-01

    An account is given of the exceptional memory of the late Professor A. C. Aitken who was also a distinguished mathematician and mental calculator. Compared with Shereshevskii, another man with exceptional memory, he shows the scholar's reliance on conceptual mapping rather than the mnemonist's reliance on perceptual chaining. (Editor)

  2. Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies.

    PubMed

    2013-02-01

    Indirect evidence suggests that common genetic variation contributes to individual differences in antidepressant efficacy among individuals with major depressive disorder, but previous studies may have been underpowered to detect these effects. A meta-analysis was performed on data from three genome-wide pharmacogenetic studies (the Genome-Based Therapeutic Drugs for Depression [GENDEP] project, the Munich Antidepressant Response Signature [MARS] project, and the Sequenced Treatment Alternatives to Relieve Depression [STAR*D] study), which included 2,256 individuals of Northern European descent with major depressive disorder, and antidepressant treatment outcomes were prospectively collected. After imputation, 1.2 million single-nucleotide polymorphisms were tested, capturing common variation for association with symptomatic improvement and remission after up to 12 weeks of antidepressant treatment. No individual association met a genome-wide threshold for statistical significance in the primary analyses. A polygenic score derived from a meta-analysis of GENDEP and MARS participants accounted for up to approximately 1.2% of the variance in outcomes in STAR*D, suggesting a weakly concordant signal distributed over many polymorphisms. An analysis restricted to 1,354 individuals treated with citalopram (STAR*D) or escitalopram (GENDEP) identified an intergenic region on chromosome 5 associated with early improvement after 2 weeks of treatment. Despite increased statistical power accorded by meta-analysis, the authors identified no reliable predictors of antidepressant treatment outcome, although they did identify modest, direct evidence that common genetic variation contributes to individual differences in antidepressant response.

  3. Evidence of common and specific genetic effects: association of the muscarinic acetylcholine receptor M2 (CHRM2) gene with alcohol dependence and major depressive syndrome.

    PubMed

    Wang, Jen C; Hinrichs, Anthony L; Stock, Heather; Budde, John; Allen, Rebecca; Bertelsen, Sarah; Kwon, Jennifer M; Wu, William; Dick, Danielle M; Rice, John; Jones, Kevin; Nurnberger, John I; Tischfield, Jay; Porjesz, Bernice; Edenberg, Howard J; Hesselbrock, Victor; Crowe, Ray; Schuckit, Mark; Begleiter, Henri; Reich, Theodore; Goate, Alison M; Bierut, Laura J

    2004-09-01

    Several correlated phenotypes, alcohol dependence, major depressive syndrome, and an endophenotype of electrophysiological measurements, event-related oscillations (EROs), have demonstrated linkage on the long arm of chromosome 7. Recently, we reported both linkage and association between polymorphisms in the gene encoding the muscarinic acetylcholine receptor M2 (CHRM2) and EROs. In this study, we evaluated whether genetic variation in the CHRM2 gene is also a risk factor for the correlated clinical characteristics of alcoholism and depression. The CHRM2 gene contains a single coding exon and a large 5' untranslated region encoded by multiple exons that can be alternatively spliced. Families were recruited through an alcohol dependent proband, and multiplex pedigrees were selected for genetic analyses. We examined 11 single nucleotide polymorphisms (SNPs) spanning the CHRM2 gene in these families. Using the UNPHASED pedigree disequilibrium test (PDTPHASE), three SNPs (one in intron 4 and two in intron 5) showed highly significant association with alcoholism (P=0.004-0.007). Two SNPs (both in intron 4) were significantly associated with major depressive syndrome (P=0.004 and 0.017). Haplotype analyses revealed that the most common haplotype (>40% frequency), T-T-T (rs1824024-rs2061174-rs324650), was under-transmitted to affected individuals with alcohol dependence and major depressive syndrome. Different complementary haplotypes were over-transmitted in alcohol dependent and depressed individuals. These findings provide strong evidence that variants within or close to the CHRM2 locus influence risk for two common psychiatric disorders.

  4. An Underlying Common Factor, Influenced by Genetics and Unique Environment, Explains the Covariation Between Major Depressive Disorder, Generalized Anxiety Disorder, and Burnout: A Swedish Twin Study.

    PubMed

    Mather, Lisa; Blom, Victoria; Bergström, Gunnar; Svedberg, Pia

    2016-12-01

    Depression and anxiety are highly comorbid due to shared genetic risk factors, but less is known about whether burnout shares these risk factors. We aimed to examine whether the covariation between major depressive disorder (MDD), generalized anxiety disorder (GAD), and burnout is explained by common genetic and/or environmental factors. This cross-sectional study included 25,378 Swedish twins responding to a survey in 2005-2006. Structural equation models were used to analyze whether the trait variances and covariances were due to additive genetics, non-additive genetics, shared environment, and unique environment. Univariate analyses tested sex limitation models and multivariate analysis tested Cholesky, independent pathway, and common pathway models. The phenotypic correlations were 0.71 (0.69-0.74) between MDD and GAD, 0.58 (0.56-0.60) between MDD and burnout, and 0.53 (0.50-0.56) between GAD and burnout. Heritabilities were 45% for MDD, 49% for GAD, and 38% for burnout; no statistically significant sex differences were found. A common pathway model was chosen as the final model. The common factor was influenced by genetics (58%) and unique environment (42%), and explained 77% of the variation in MDD, 69% in GAD, and 44% in burnout. GAD and burnout had additive genetic factors unique to the phenotypes (11% each), while MDD did not. Unique environment explained 23% of the variability in MDD, 20% in GAD, and 45% in burnout. In conclusion, the covariation was explained by an underlying common factor, largely influenced by genetics. Burnout was to a large degree influenced by unique environmental factors not shared with MDD and GAD.

  5. Analysis of Major Histocompatibility Complex-Bound HIV Peptides Identified from Various Cell Types Reveals Common Nested Peptides and Novel T Cell Responses.

    PubMed

    Rucevic, Marijana; Kourjian, Georgio; Boucau, Julie; Blatnik, Renata; Garcia Bertran, Wilfredo; Berberich, Matthew J; Walker, Bruce D; Riemer, Angelika B; Le Gall, Sylvie

    2016-10-01

    Despite the critical role of epitope presentation for immune recognition, we still lack a comprehensive definition of HIV peptides presented by HIV-infected cells. Here we identified 107 major histocompatibility complex (MHC)-bound HIV peptides directly from the surface of live HIV-transfected 293T cells, HIV-infected B cells, and primary CD4 T cells expressing a variety of HLAs. The majority of peptides were 8 to 12 amino acids (aa) long and mostly derived from Gag and Pol. The analysis of the total MHC-peptidome and of HLA-A02-bound peptides identified new noncanonical HIV peptides of up to 16 aa that could not be predicted by HLA anchor scanning and revealed an heterogeneous surface peptidome. Nested sets of surface HIV peptides included optimal and extended HIV epitopes and peptides partly overlapping or distinct from known epitopes, revealing new immune responses in HIV-infected persons. Surprisingly, in all three cell types, a majority of Gag peptides derived from p15 rather than from the most immunogenic p24. The cytosolic degradation of peptide precursors in corresponding cells confirmed the generation of identified surface-nested peptides. Cytosolic degradation revealed peptides commonly produced in all cell types and displayed by various HLAs, peptides commonly produced in all cell types and selectively displayed by specific HLAs, and peptides produced in only one cell type. Importantly, we identified areas of proteins leading to common presentations of noncanonical peptides by several cell types with distinct HLAs. These peptides may benefit the design of immunogens, focusing T cell responses on relevant markers of HIV infection in the context of HLA diversity. The recognition of HIV-infected cells by immune T cells relies on the presentation of HIV-derived peptides by diverse HLA molecules at the surface of cells. The landscape of HIV peptides displayed by HIV-infected cells is not well defined. Considering the diversity of HLA molecules in the human

  6. Analysis of Major Histocompatibility Complex-Bound HIV Peptides Identified from Various Cell Types Reveals Common Nested Peptides and Novel T Cell Responses

    PubMed Central

    Rucevic, Marijana; Kourjian, Georgio; Boucau, Julie; Blatnik, Renata; Garcia Bertran, Wilfredo; Berberich, Matthew J.; Walker, Bruce D.; Riemer, Angelika B.

    2016-01-01

    ABSTRACT Despite the critical role of epitope presentation for immune recognition, we still lack a comprehensive definition of HIV peptides presented by HIV-infected cells. Here we identified 107 major histocompatibility complex (MHC)-bound HIV peptides directly from the surface of live HIV-transfected 293T cells, HIV-infected B cells, and primary CD4 T cells expressing a variety of HLAs. The majority of peptides were 8 to 12 amino acids (aa) long and mostly derived from Gag and Pol. The analysis of the total MHC-peptidome and of HLA-A02-bound peptides identified new noncanonical HIV peptides of up to 16 aa that could not be predicted by HLA anchor scanning and revealed an heterogeneous surface peptidome. Nested sets of surface HIV peptides included optimal and extended HIV epitopes and peptides partly overlapping or distinct from known epitopes, revealing new immune responses in HIV-infected persons. Surprisingly, in all three cell types, a majority of Gag peptides derived from p15 rather than from the most immunogenic p24. The cytosolic degradation of peptide precursors in corresponding cells confirmed the generation of identified surface-nested peptides. Cytosolic degradation revealed peptides commonly produced in all cell types and displayed by various HLAs, peptides commonly produced in all cell types and selectively displayed by specific HLAs, and peptides produced in only one cell type. Importantly, we identified areas of proteins leading to common presentations of noncanonical peptides by several cell types with distinct HLAs. These peptides may benefit the design of immunogens, focusing T cell responses on relevant markers of HIV infection in the context of HLA diversity. IMPORTANCE The recognition of HIV-infected cells by immune T cells relies on the presentation of HIV-derived peptides by diverse HLA molecules at the surface of cells. The landscape of HIV peptides displayed by HIV-infected cells is not well defined. Considering the diversity of HLA

  7. Common and distinct patterns of grey-matter volume alteration in major depression and bipolar disorder: evidence from voxel-based meta-analysis.

    PubMed

    Wise, T; Radua, J; Via, E; Cardoner, N; Abe, O; Adams, T M; Amico, F; Cheng, Y; Cole, J H; de Azevedo Marques Périco, C; Dickstein, D P; Farrow, T F D; Frodl, T; Wagner, G; Gotlib, I H; Gruber, O; Ham, B J; Job, D E; Kempton, M J; Kim, M J; Koolschijn, P C M P; Malhi, G S; Mataix-Cols, D; McIntosh, A M; Nugent, A C; O'Brien, J T; Pezzoli, S; Phillips, M L; Sachdev, P S; Salvadore, G; Selvaraj, S; Stanfield, A C; Thomas, A J; van Tol, M J; van der Wee, N J A; Veltman, D J; Young, A H; Fu, C H; Cleare, A J; Arnone, D

    2016-05-24

    Finding robust brain substrates of mood disorders is an important target for research. The degree to which major depression (MDD) and bipolar disorder (BD) are associated with common and/or distinct patterns of volumetric changes is nevertheless unclear. Furthermore, the extant literature is heterogeneous with respect to the nature of these changes. We report a meta-analysis of voxel-based morphometry (VBM) studies in MDD and BD. We identified studies published up to January 2015 that compared grey matter in MDD (50 data sets including 4101 individuals) and BD (36 data sets including 2407 individuals) using whole-brain VBM. We used statistical maps from the studies included where available and reported peak coordinates otherwise. Group comparisons and conjunction analyses identified regions in which the disorders showed common and distinct patterns of volumetric alteration. Both disorders were associated with lower grey-matter volume relative to healthy individuals in a number of areas. Conjunction analysis showed smaller volumes in both disorders in clusters in the dorsomedial and ventromedial prefrontal cortex, including the anterior cingulate cortex and bilateral insula. Group comparisons indicated that findings of smaller grey-matter volumes relative to controls in the right dorsolateral prefrontal cortex and left hippocampus, along with cerebellar, temporal and parietal regions were more substantial in major depression. These results suggest that MDD and BD are characterised by both common and distinct patterns of grey-matter volume changes. This combination of differences and similarities has the potential to inform the development of diagnostic biomarkers for these conditions.Molecular Psychiatry advance online publication, 24 May 2016; doi:10.1038/mp.2016.72.

  8. Mining the genomes of exceptional responders.

    PubMed

    Chang, David K; Grimmond, Sean M; Evans, T R Jeffry; Biankin, Andrew V

    2014-05-01

    The National Cancer Institute of the United States recently announced a major new initiative in understanding the genomes or, more broadly, the molecular phenotypes of exceptional responders. What can we expect to learn from exceptional responders? What are the potential benefits, and how do we approach studying them?

  9. Exceptional Parent, 2001.

    ERIC Educational Resources Information Center

    Rader, Rick, Ed.

    2001-01-01

    This document collects the 12 monthly issues of Volume 31 of "Exceptional Parent," a magazine focused on practical advice for parents of children with disabilities. Most of the issues include a focus topic as well as articles on other issues, columns, reviews, and letters. These 12 issues concentrate on the following areas: (1)…

  10. Exceptional Children Research Review.

    ERIC Educational Resources Information Center

    Johnson, G. Orville, Ed.; Blank, Harriett D., Ed.

    Research reviews are presented for eight areas of exceptionality and for administration. Included are the following reports: 16 on the gifted compiled by Edward C. Frierson; 46 on the mentally retarded reviewed by Howard H. Spicker and Nettie R. Bartel; 20 on the visually impaired presented by William J. Tisdall; 44 on the hearing impaired…

  11. Exceptional Parent, 2001.

    ERIC Educational Resources Information Center

    Rader, Rick, Ed.

    2001-01-01

    This document collects the 12 monthly issues of Volume 31 of "Exceptional Parent," a magazine focused on practical advice for parents of children with disabilities. Most of the issues include a focus topic as well as articles on other issues, columns, reviews, and letters. These 12 issues concentrate on the following areas: (1)…

  12. Exceptional Parent, 2000.

    ERIC Educational Resources Information Center

    Rader, Rick, Ed.

    2000-01-01

    This document collects the 12 monthly issues of Volume 30 of "Exceptional Parent," a magazine focused on practical advice for parents of children with disabilities. Most issues include a focus topic as well as articles on other issues, columns, reviews, and letters. The issues focus on the following areas: (1) an extensive resource guide; (2)…

  13. Exceptional Parent, 1995.

    ERIC Educational Resources Information Center

    Klein, Stanley, Ed.

    1995-01-01

    Twelve issues of "Exceptional Parent" magazine provide a variety of articles and resources on parenting the child or young adult with a disability. The January issue is a resource guide with directories of national organizations, associations, products, and services. The February issue focuses on early childhood, including assessment, day care,…

  14. Exceptional Parent, 1996.

    ERIC Educational Resources Information Center

    Klein, Stanley, Ed.

    1996-01-01

    Twelve 1996 issues of "Exceptional Parent" magazine provide a variety of articles and resources on parenting the child or young adult with a disability. The January issue is a resource guide, with directories of national organizations, associations, products, and services. The February issue focuses on early childhood, including articles…

  15. On Exceptional Superconformal Algebras

    SciTech Connect

    Poletaeva, Elena

    2010-06-17

    We obtain realizations of superconformal algebras K(2), K'(4) and the exceptional N = 6 superconformal algebra in matrices over a Weyl algebra of size 2x2, 4x4 and 8x8, respectively. A general construction of these realizations is based on the spin representations of the orthogonal Lie algebras. We give explicit descriptions of these matrix realizations.

  16. Exceptional Parent, 1996.

    ERIC Educational Resources Information Center

    Klein, Stanley, Ed.

    1996-01-01

    Twelve 1996 issues of "Exceptional Parent" magazine provide a variety of articles and resources on parenting the child or young adult with a disability. The January issue is a resource guide, with directories of national organizations, associations, products, and services. The February issue focuses on early childhood, including articles…

  17. Nothing Exceptional: Against Agamben

    ERIC Educational Resources Information Center

    Colatrella, Steven

    2011-01-01

    Giorgio Agamben's work has become widely influential as a guide to explaining the extra-constitutional powers assumed by governments under the rubric of the War on Terror. His formulations, such as Homo Sacer and State of Exception, have been extended to apply to a wide variety of experiences of repression of liberties or social control, including…

  18. Nothing Exceptional: Against Agamben

    ERIC Educational Resources Information Center

    Colatrella, Steven

    2011-01-01

    Giorgio Agamben's work has become widely influential as a guide to explaining the extra-constitutional powers assumed by governments under the rubric of the War on Terror. His formulations, such as Homo Sacer and State of Exception, have been extended to apply to a wide variety of experiences of repression of liberties or social control, including…

  19. Evidence for Directional Selection at a Novel Major Histocompatibility Class I Marker in Wild Common Frogs (Rana temporaria) Exposed to a Viral Pathogen (Ranavirus)

    PubMed Central

    Teacher, Amber G. F.; Garner, Trenton W. J.; Nichols, Richard A.

    2009-01-01

    Whilst the Major Histocompatibility Complex (MHC) is well characterized in the anuran Xenopus, this region has not previously been studied in another popular model species, the common frog (Rana temporaria). Nor, to date, have there been any studies of MHC in wild amphibian host-pathogen systems. We characterise an MHC class I locus in the common frog, and present primers to amplify both the whole region, and specifically the antigen binding region. As no more than two expressed haplotypes were found in over 400 clones from 66 individuals, it is likely that there is a single class I locus in this species. This finding is consistent with the single class I locus in Xenopus, but contrasts with the multiple loci identified in axolotls, providing evidence that the diversification of MHC class I into multiple loci likely occurred after the Caudata/Anura divergence (approximately 350 million years ago) but before the Ranidae/Pipidae divergence (approximately 230 mya). We use this locus to compare wild populations of common frogs that have been infected with a viral pathogen (Ranavirus) with those that have no history of infection. We demonstrate that certain MHC supertypes are associated with infection status (even after accounting for shared ancestry), and that the diseased populations have more similar supertype frequencies (lower FST) than the uninfected. These patterns were not seen in a suite of putatively neutral microsatellite loci. We interpret this pattern at the MHC locus to indicate that the disease has imposed selection for particular haplotypes, and hence that common frogs may be adapting to the presence of Ranavirus, which currently kills tens of thousands of amphibians in the UK each year. PMID:19240796

  20. Dibaryons from Exceptional Collections

    NASA Astrophysics Data System (ADS)

    Herzog, Christopher P.; Walcher, Johannes

    2003-09-01

    We discuss aspects of the dictionary between brane configurations in del Pezzo geometries and dibaryons in the dual superconformal quiver gauge theories. The basis of fractional branes defining the quiver theory at the singularity has a K-theoretic dual exceptional collection of bundles which can be used to read off the spectrum of dibaryons in the weakly curved dual geometry. Our prescription identifies the R-charge R and all baryonic U(1) charges QI with divisors in the del Pezzo surface without any Weyl group ambiguity. As one application of the correspondence, we identify the cubic anomaly trRQIQJ as an intersection product for dibaryon charges in large-N superconformal gauge theories. Examples can be given for all del Pezzo surfaces using three- and four-block exceptional collections. Markov-type equations enforce consistency among anomaly equations for three-block collections.

  1. Common Genetic Risk of Major Depression and Nicotine Dependence: The Contribution of Antisocial Traits in a United States Veteran Male Twin Cohort

    PubMed Central

    Fu, Qiang; Heath, Andrew C.; Bucholz, Kathleen K.; Lyons, Michael J.; Tsuang, Ming T.; True, William R.; Eisen, Seth A.

    2012-01-01

    Many studies that found associations between depression and nicotine dependence have ignored possible shared genetic influences associated with antisocial traits. The present study examined the contribution of genetic and environmental effects associated with conduct disorder (CD) and antisocial personality disorder (ASPD) to the comorbidity of major depression (MD) and nicotine dependence (ND). A telephone diagnostic interview, the Diagnostic Interview Schedule-III-R, was administered to eligible twins from the Vietnam Era Twin (VET) Registry in 1992. Multivariate genetic models were fitted to 3360 middle-aged and predominantly white twin pairs (1868 monozygotic, 1492 dizygotic pairs) of which both members completed the pertinent diagnostic interview sections. Genetic influences on CD accounted for 100%, 68%, and 50% of the total genetic variance in risk for ASPD, MD and ND, respectively. After controlling for genetic influences on CD, the partial genetic correlation between MD and ND was no longer statistically significant. Nonshared environmental contributions to the comorbidity among these disorders were not significant. This study not only demonstrates that the comorbidity between ND and MD is influenced by common genetic risk factors, but also further suggests that the common genetic risk factors overlapped with those for antisocial traits such as CD and ASPD in men. PMID:17564505

  2. Evaluation of the genetic parameters for 10 common and five new ESS core autosomal STR loci in seven major geographic regions and the largest metropolitan province of Turkey.

    PubMed

    Canturk, Kemal Murat; Gurkan, Cemal; Sevay, Huseyin; Emre, Ramazan

    2017-03-01

    Situated at the crossroads of Asia, Middle East and Europe, Turkey has an ethnically diverse population of over 78 milllion people. To investigate the population genetics and potential differences in the autosomal short tandem repeat (STR) polymorphisms across all the major geographic regions and largest metropolitan province of Turkey within the context of the Near Eastern/European genetic landscape. Samples from a total of 5299 unrelated individuals were analysed at 10 common [D2S1338, D3S1358, D8S1179, D16S539, D18S51, D19S433, D21S11, FGA, TH01, vWA] and five new European Standard Set (ESS) core autosomal STR loci [D1S1656, D2S441, D10S1248, D12S391, D22S1045]. Allele frequencies, statistical parameters of forensic interest and population differentiation tests were calculated for nine population datasets corresponding to the seven major geographic regions, the largest metropolitan province, and a combined dataset for the entire country. Cumulative results confirmed the presence of significant differences among these nine autosomal datasets themselves and with those from the nearby populations, therefore justifying the differential use of these separate datasets on a case-by-case basis in forensic investigations. This collection of autosomal STR population datasets comprises the largest and most comprehensive of its kind from Turkey so far.

  3. fw 2.2:a major QTL controlling fruit weight is common to both red- and green-fruited tomato species.

    PubMed

    Alpert, K B; Grandillo, S; Tanksley, S D

    1995-11-01

    We have shown that a major QTL for fruit weight (fw2.2) maps to the same position on chromosome 2 in the green-fruited wild tomato species, Lycopersicon pennellii and in the red-fruited wild tomato species, L. pimpinellifolium. An introgression line F2 derived from L. esculentum (tomato) x L. pennellii and a backcross 1 (BC1) population derived from L. esculentum x L. pimpinellifolium both place fw2.2 near TG91 and TG167 on chromosome 2 of the tomato highdensity linkage map. fw2.2 accounts for 30% and 47% of the total phenotypic variance in the L. pimpinellifolium and L. pennellii populations, respectively, indicating that this is a major QTL controlling fruit weight in both species. Partial dominance (d/a of 0.44) was observed for the L. pennellii allele of fw 2.2 as compared with the L. esculentum allele. A QTL with very similar phenotypic affects and gene action has also been identified and mapped to the same chromosomal region in other wild tomato accessions: L. cheesmanii and L. pimpinellifolium. Together, these data suggest that fw2.2 represents an orthologous QTL (i.e., derived by speciation as opposed to duplication) common to most, if not all, wild tomato species. High-resolution mapping may ultimately lead to the cloning of this key locus controlling fruit development in tomato.

  4. ADIFOR exception handling

    SciTech Connect

    Bischof, C.; Corliss, G.; Griewank, A.

    1992-01-01

    Automatic differentiation uses recurrence relations based on the rules of calculus. Consequently, the results are guaranteed to be correct only in the relevant mathematical assumptions are satisfied at least in a neighborhood of the current argument. Computer programs may violate these conditions by branching or by calling intrinsic functions such as abs, max, sqrt, and asin at point where their derivative is undefined or infinite. The resulting dependence between the program's input and output variables may still be differentiable, because branch vales fit together smoothly or nondifferentiabilities cancel each other out. We have two objectives. First, we would like to assure the user that the function being evaluated is indeed locally differentiable because all intrinsics are evaluated at smooth arguments and none of the branching tests are critical. Second, the derivative program should run even when the assumptions of the chain rule are not strictly satisfied. In this case, the numerical results represent at least generalized derivations under reasonable (but usually unverifiable) regularity assumptions. To achieve these two goals, we must take into account the effects of finite-precision arithmetic. This paper addresses the detection and handling of exceptions. It is an exception in the ADIFOR-generated code to evaluate a function at a point at which the function may not be mathematically differentiable. When an exception is detected by tests written into the ADIFOR-generated code, an error handler is called. The error handler prints an error message (optionally), halts execution (optionally), and returns a value that allows the user's client program to detect that a requested derivative is not available. Code is included for all of the necessary Fortran intrinsic functions and for the error handler.

  5. Infection of Common Marmosets with GB Virus B Chimeric Virus Encoding the Major Nonstructural Proteins NS2 to NS4A of Hepatitis C Virus.

    PubMed

    Zhu, Shaomei; Li, Tingting; Liu, Bochao; Xu, Yuxia; Sun, Yachun; Wang, Yilin; Wang, Yuanzhan; Shuai, Lifang; Chen, Zixuan; Allain, Jean-Pierre; Li, Chengyao

    2016-09-15

    A lack of immunocompetent-small-primate models has been an obstacle for developing hepatitis C virus (HCV) vaccines and affordable antiviral drugs. In this study, HCV/GB virus B (GBV-B) chimeric virus carrying the major nonstructural proteins NS2 to NS4A (HCV NS2 to -4A chimera) was produced and used to infect common marmosets, since HCV NS2 to NS4A proteins are critical proteases and major antigens. Seven marmosets were inoculated intrahepatically with HCV NS2 to -4A chimera RNA for primary infection or intravenously injected with chimera-containing serum for passage infection. Three animals used as controls were injected with phosphate-buffered saline (PBS) or GBV-B, respectively. Six of seven HCV NS2 to -4A chimera-infected marmosets exhibited consistent viremia and one showed transient viremia during the course of follow-up detection. All six infected animals with persistent circulating viremia presented characteristics typical of viral hepatitis, including viral RNA and proteins in hepatocytes and histopathological changes in liver tissue. Viremia was consistently detected for 5 to 54 weeks of follow-up. FK506 immunosuppression facilitated the establishment of persistent chimera infection in marmosets. An animal with chimera infection spontaneously cleared the virus in blood 7 weeks following the first inoculation, but viral-RNA persistence, low-level viral protein, and mild necroinflammation remained in liver tissue. The specific antibody and T-cell response to HCV NS3 in this viremia-resolved marmoset was boosted by rechallenging, but no viremia was detected during 57 weeks of follow-up. The chimera-infected marmosets described can be used as a suitable small-primate animal model for studying novel antiviral drugs and T-cell-based vaccines against HCV infection. HCV infection causes approximately 70% of chronic hepatitis and is frequently associated with primary liver cancer globally. Chimpanzees have been used as a reliable primate model for HCV infection

  6. Three major haplotypes of the β2 adrenergic receptor define psychological profile, blood pressure, and the risk for development of a common musculoskeletal pain disorder

    PubMed Central

    Diatchenko, Luda; Anderson, Amy D.; Slade, Gary D.; Fillingim, Roger B.; Shabalina, Svetlana A.; Higgins, Tomas; Sama, Swetha; Belfer, Inna; Goldman, David; Max, Mitchell B.; Weir, Bruce S.; Maixner, William

    2008-01-01

    Adrenergic receptor β2 (ADRB2) is a primary target for epinephrine. It plays a critical role in mediating physiological and psychological responses to environmental stressors. Thus, functional genetic variants of ADRB2 will be associated with a complex array of psychological and physiological phenotypes. These genetic variants should also interact with environmental factors such as physical or emotional stress to produce a phenotype vulnerable to pathological states. In this study, we determined whether common genetic variants of ADRB2 contribute to the development of a common chronic pain condition that is associated with increased levels of psychological distress and low blood pressure, factors which are strongly influenced by the adrenergic system. We genotyped 202 female subjects and examined the relationships between three major ADRB2 haplotypes and psychological factors, resting blood pressure, and the risk of developing a chronic musculoskeletal pain condition - Temporomandibular Joint Disorder (TMD). We propose that the first haplotype codes for lower levels of ADRB2 expression, the second haplotype codes for higher ADRB2 expression, and the third haplotype codes for higher receptor expression and rapid agonist-induced internalization. Individuals who carried one haplotype coding for high and one coding for low ADRB2 expression displayed the highest positive psychological traits, had higher levels of resting arterial pressure, and were about 10 times less likely to develop TMD. Thus, our data suggest that either positive or negative imbalances in ADRB2 function increase the vulnerability to chronic pain conditions such as TMD through different etiological pathways that imply the need for tailored treatment options. PMID:16741943

  7. From genome-wide to candidate gene: an investigation of variation at the major histocompatibility complex in common bottlenose dolphins exposed to harmful algal blooms.

    PubMed

    Cammen, Kristina M; Wilcox, Lynsey A; Rosel, Patricia E; Wells, Randall S; Read, Andrew J

    2015-02-01

    The role the major histocompatibility complex (MHC) plays in response to exposure to environmental toxins is relatively poorly understood, particularly in comparison to its well-described role in pathogen immunity. We investigated associations between MHC diversity and resistance to brevetoxins in common bottlenose dolphins (Tursiops truncatus). A previous genome-wide association study investigating an apparent difference in harmful algal bloom (HAB) resistance among dolphin populations in the Gulf of Mexico identified genetic variation associated with survival in close genomic proximity to multiple MHC class II loci. Here, we characterized genetic variation at DQA, DQB, DRA, and DRB loci in dolphins from central-west Florida and the Florida Panhandle, including dolphins that died during HABs and dolphins presumed to have survived HAB exposure. We found that DRB and DQB exhibited patterns of genetic differentiation among geographic regions that differed from neutral microsatellite loci. In addition, genetic differentiation at DRB across multiple pairwise comparisons of live and dead dolphins was greater than differentiation observed at neutral loci. Our findings at these MHC loci did not approach the strength of association with survival previously described for a nearby genetic variant. However, the results provide evidence that selective pressures at the MHC vary among dolphin populations that differ in the frequency of HAB exposure and that the overall composition of DRB variants differs between dolphin survivors and non-survivors of HABs. These results may suggest a potential role of MHC diversity in variable survival of bottlenose dolphins exposed to HABs.

  8. Giftedness: an exceptionality examined.

    PubMed

    Robinson, A; Clinkenbeard, P R

    1998-01-01

    The study of giftedness has practical origins. High-level performance intrigues people. Theoretically, the study of giftedness is related to the psychology of individual differences and has focused on the constructs of intelligence, creativity, and motivation. At a practical level, the research is largely related to school and family contexts, which develop gifts and talents in children and youth. Although broadened definitions of giftedness have emerged, the most extensive body of research available for review concentrates on intellectual giftedness. The varying definitions of giftedness and the impact of social context and diversity on the development of talent pose significant challenges for the field. Finally, the study of exceptionally advanced performance provides insight into basic psychological processes and the school contexts that develop talents in children and youth.

  9. Counseling Exceptional People.

    ERIC Educational Resources Information Center

    Benjamin, Libby; Walz, Garry R.

    This guide offers counselors and special education and classroom teachers assistance in counseling handicapped children. Major articles focus on counseling children who are mentally retarded, emotionally, visually and hearing impaired, learning disabled, and gifted. Additional information is provided on: (1) sexual fulfillment for the handicapped;…

  10. Acute kidney injury is common, parallels organ dysfunction or failure, and carries appreciable mortality in patients with major burns: a prospective exploratory cohort study.

    PubMed

    Steinvall, I; Bak, Z; Sjoberg, F

    2008-01-01

    The purpose of this study was to determine the incidence, time course, and outcome of acute kidney injury after major burns and to evaluate the impact of possible predisposing factors (age, gender, and depth and extent of injury) and the relation to other dysfunctioning organs and sepsis. We performed an explorative cohort study on patients with a TBSA% (percentage burned of total body surface area) of 20% or more who were admitted to a national burn centre. Acute kidney injury was classified according to the international consensus classification of RIFLE (Risk, Injury, Failure, Loss of kidney function, and End-stage kidney disease). Prospectively collected clinical and laboratory data were used for assessing organ dysfunction, systemic inflammatory response, and sepsis. The incidence of acute kidney injury among major burns was 0.11 per 100,000 people per year. Of 127 patients, 31 (24%) developed acute kidney injury (12% Risk, 8% Injury, and 5% Failure). Mean age was 40.6 years (95% confidence interval [CI] 36.7 to 44.5), TBSA% was 38.6% (95% CI 35.5% to 41.6%), and 25% were women. Mortality was 14% and increased with increasing RIFLE class (7% normal, 13% Risk, 40% Injury, and 83% Failure). Renal dysfunction occurred within 7 days in 55% of the patients and recovered among all survivors. Age, TBSA%, and extent of full thickness burns were higher among the patients who developed acute kidney injury. Pulmonary dysfunction and systemic inflammatory response syndrome were present in all of the patients with acute kidney injury and developed before the acute kidney injury. Sepsis was a possible aggravating factor in acute kidney injury in 48%. Extensive deep burns (25% or more full thickness burn) increased the risk for developing acute kidney injury early (risk ratio 2.25). Acute kidney injury is common, develops soon after the burn, and parallels other dysfunctioning organs. Although acute kidney injury recovered in all survivors, in higher acute kidney injury

  11. Acute kidney injury is common, parallels organ dysfunction or failure, and carries appreciable mortality in patients with major burns: a prospective exploratory cohort study

    PubMed Central

    Steinvall, I; Bak, Z; Sjoberg, F

    2008-01-01

    Introduction The purpose of this study was to determine the incidence, time course, and outcome of acute kidney injury after major burns and to evaluate the impact of possible predisposing factors (age, gender, and depth and extent of injury) and the relation to other dysfunctioning organs and sepsis. Method We performed an explorative cohort study on patients with a TBSA% (percentage burned of total body surface area) of 20% or more who were admitted to a national burn centre. Acute kidney injury was classified according to the international consensus classification of RIFLE (Risk, Injury, Failure, Loss of kidney function, and End-stage kidney disease). Prospectively collected clinical and laboratory data were used for assessing organ dysfunction, systemic inflammatory response, and sepsis. Results The incidence of acute kidney injury among major burns was 0.11 per 100,000 people per year. Of 127 patients, 31 (24%) developed acute kidney injury (12% Risk, 8% Injury, and 5% Failure). Mean age was 40.6 years (95% confidence interval [CI] 36.7 to 44.5), TBSA% was 38.6% (95% CI 35.5% to 41.6%), and 25% were women. Mortality was 14% and increased with increasing RIFLE class (7% normal, 13% Risk, 40% Injury, and 83% Failure). Renal dysfunction occurred within 7 days in 55% of the patients and recovered among all survivors. Age, TBSA%, and extent of full thickness burns were higher among the patients who developed acute kidney injury. Pulmonary dysfunction and systemic inflammatory response syndrome were present in all of the patients with acute kidney injury and developed before the acute kidney injury. Sepsis was a possible aggravating factor in acute kidney injury in 48%. Extensive deep burns (25% or more full thickness burn) increased the risk for developing acute kidney injury early (risk ratio 2.25). Conclusions Acute kidney injury is common, develops soon after the burn, and parallels other dysfunctioning organs. Although acute kidney injury recovered in all

  12. Exceptional composite dark matter

    NASA Astrophysics Data System (ADS)

    Ballesteros, Guillermo; Carmona, Adrián; Chala, Mikael

    2017-07-01

    We study the dark matter phenomenology of non-minimal composite Higgs models with SO(7) broken to the exceptional group G_2. In addition to the Higgs, three pseudo-Nambu-Goldstone bosons arise, one of which is electrically neutral. A parity symmetry is enough to ensure this resonance is stable. In fact, if the breaking of the Goldstone symmetry is driven by the fermion sector, this Z_2 symmetry is automatically unbroken in the electroweak phase. In this case, the relic density, as well as the expected indirect, direct and collider signals are then uniquely determined by the value of the compositeness scale, f. Current experimental bounds allow one to account for a large fraction of the dark matter of the Universe if the dark matter particle is part of an electroweak triplet. The totality of the relic abundance can be accommodated if instead this particle is a composite singlet. In both cases, the scale f and the dark matter mass are of the order of a few TeV.

  13. Are There Common Familial Influences for Major Depressive Disorder and an Overeating-Binge Eating Dimension in both European-American and African-American Female Twins?

    PubMed Central

    Munn-Chernoff, Melissa A.; Grant, Julia D.; Agrawal, Arpana; Koren, Rachel; Glowinski, Anne L.; Bucholz, Kathleen K.; Madden, Pamela A. F.; Heath, Andrew C.; Duncan, Alexis E.

    2014-01-01

    Objective Although prior studies have demonstrated that depression is associated with an overeating-binge eating dimension (OE-BE), phenotypically, little research has investigated whether familial factors contribute to the co-occurrence of these phenotypes, especially in community samples with multiple racial/ethnic groups. We examined the extent to which familial (i.e., genetic and shared environmental) influences overlapped between Major Depressive Disorder (MDD) and OE-BE in a population-based sample and whether these influences were similar across racial/ethnic groups Method Participants included 3226 European-American (EA) and 550 African-American (AA) young adult women from the Missouri Adolescent Female Twin Study. An adaptation of the Semi-Structured Assessment for the Genetics of Alcoholism (SSAGA) was administered to assess lifetime DSM-IV MDD and OE-BE. Quantitative genetic modeling was used to estimate familial influences between both phenotypes; all models controlled for age. Results The best-fitting model, which combined racial/ethnic groups, found that additive genetic influences accounted for 44% (95% CI: 34%, 53%) of the MDD variance and 40% (25%, 54%) for OE-BE, with the remaining variances due to non-shared environmental influences. Genetic overlap was substantial (rg = .61 [.39, .85]); non-shared environmental influences on MDD and OE-BE overlapped weakly (re = .26 [.09, .42]) Discussion Results suggest that common familial influences underlie MDD and OE-BE, and the magnitude of familial influences contributing to the comorbidity between MDD and OE-BE is similar between EA and AA women. If racial/ethnic differences truly exist, then larger sample sizes may be needed to fully elucidate familial risk for comorbid MDD and OE-BE across these groups. PMID:24659561

  14. Comparative genome analysis of the major histocompatibility complex (MHC) class I B/C segments in primates elucidated by genomic sequencing in common marmoset (Callithrix jacchus).

    PubMed

    Shiina, Takashi; Kono, Azumi; Westphal, Nico; Suzuki, Shingo; Hosomichi, Kazuyoshi; Kita, Yuki F; Roos, Christian; Inoko, Hidetoshi; Walter, Lutz

    2011-08-01

    Common marmoset monkeys (Callithrix jacchus) have emerged as important animal models for biomedical research, necessitating a more extensive characterization of their major histocompatibility complex (MHC) region. However, the genomic information of the marmoset MHC (Caja) is still lacking. The MHC-B/C segment represents the most diverse MHC region among primates. Therefore, in this paper, to elucidate the detailed gene organization and evolutionary processes of the Caja class I B (Caja-B) segment, we determined two parts of the Caja-B sequences with 1,079 kb in total, ranging from H6orf15 to BAT1 and compared the structure and phylogeny with that of other primates. This segment contains 54 genes in total, nine Caja-B genes (Caja-B1 to Caja-B9), two MIC genes (MIC1 and MIC2), eight non-MHC genes, two non-coding genes, and 33 non-MHC pseudogenes that have not been observed in other primate MHC-B/C segments. Caja-B3, Caja-B4, and Caja-B7 encode proper MHC class I proteins according to amino acid structural characteristics. Phylogenetic relationships based on 48 MHC-I nucleotide sequences in primates suggested (1) species-specific divergence for Caja, Mamu, and HLA/Patr/Gogo lineages, (2) independent generation of the "seven coding exon" type MHC-B genes in Mamu and HLA/Patr/Gogo lineages from an ancestral "eight coding exon" type MHC-I gene, (3) parallel correlation with the long and short segmental duplication unit length in Caja and Mamu lineages. These findings indicate that the MHC-B/C segment has been under permanent selective pressure in the evolution of primates.

  15. Students' Strategies for Exception Handling

    ERIC Educational Resources Information Center

    Rashkovits, Rami; Lavy, Ilana

    2011-01-01

    This study discusses and presents various strategies employed by novice programmers concerning exception handling. The main contributions of this paper are as follows: we provide an analysis tool to measure the level of assimilation of exception handling mechanism; we present and analyse strategies to handle exceptions; we present and analyse…

  16. Students' Strategies for Exception Handling

    ERIC Educational Resources Information Center

    Rashkovits, Rami; Lavy, Ilana

    2011-01-01

    This study discusses and presents various strategies employed by novice programmers concerning exception handling. The main contributions of this paper are as follows: we provide an analysis tool to measure the level of assimilation of exception handling mechanism; we present and analyse strategies to handle exceptions; we present and analyse…

  17. The major nucleoside triphosphatase in pea (Pisum sativum L.) nuclei and in rat liver nuclei share common epitopes also present in nuclear lamins

    NASA Technical Reports Server (NTRS)

    Tong, C. G.; Dauwalder, M.; Clawson, G. A.; Hatem, C. L.; Roux, S. J.

    1993-01-01

    The major nucleoside triphosphatase (NTPase) activities in mammalian and pea (Pisum sativum L.) nuclei are associated with enzymes that are very similar both biochemically and immunochemically. The major NTPase from rat liver nuclei appears to be a 46-kD enzyme that represents the N-terminal portion of lamins A and C, two lamina proteins that apparently arise from the same gene by alternate splicing. Monoclonal antibody (MAb) G2, raised to human lamin C, both immunoprecipitates the major (47 kD) NTPase in pea nuclei and recognizes it in western blot analyses. A polyclonal antibody preparation raised to the 47-kD pea NTPase (pc480) reacts with the same lamin bands that are recognized by MAb G2 in mammalian nuclei. The pc480 antibodies also bind to the same lamin-like bands in pea nuclear envelope-matrix preparations that are recognized by G2 and three other MAbs known to bind to mammalian lamins. In immunofluorescence assays, pc480 and anti-lamin antibodies stain both cytoplasmic and nuclear antigens in plant cells, with slightly enhanced staining along the periphery of the nuclei. These results indicate that the pea and rat liver NTPases are structurally similar and that, in pea nuclei as in rat liver nuclei, the major NTPase is probably derived from a lamin precursor by proteolysis.

  18. The major nucleoside triphosphatase in pea (Pisum sativum L.) nuclei and in rat liver nuclei share common epitopes also present in nuclear lamins

    NASA Technical Reports Server (NTRS)

    Tong, C. G.; Dauwalder, M.; Clawson, G. A.; Hatem, C. L.; Roux, S. J.

    1993-01-01

    The major nucleoside triphosphatase (NTPase) activities in mammalian and pea (Pisum sativum L.) nuclei are associated with enzymes that are very similar both biochemically and immunochemically. The major NTPase from rat liver nuclei appears to be a 46-kD enzyme that represents the N-terminal portion of lamins A and C, two lamina proteins that apparently arise from the same gene by alternate splicing. Monoclonal antibody (MAb) G2, raised to human lamin C, both immunoprecipitates the major (47 kD) NTPase in pea nuclei and recognizes it in western blot analyses. A polyclonal antibody preparation raised to the 47-kD pea NTPase (pc480) reacts with the same lamin bands that are recognized by MAb G2 in mammalian nuclei. The pc480 antibodies also bind to the same lamin-like bands in pea nuclear envelope-matrix preparations that are recognized by G2 and three other MAbs known to bind to mammalian lamins. In immunofluorescence assays, pc480 and anti-lamin antibodies stain both cytoplasmic and nuclear antigens in plant cells, with slightly enhanced staining along the periphery of the nuclei. These results indicate that the pea and rat liver NTPases are structurally similar and that, in pea nuclei as in rat liver nuclei, the major NTPase is probably derived from a lamin precursor by proteolysis.

  19. From Ethical Exceptionalism to Ethical Exceptions: The Rule and exception Model and the Changing Meaning of Ethics In German Bioregulation.

    PubMed

    Braun, Kathrin

    2016-02-12

    Germany is an interesting case with respect to the governance of reprogenetics. It has a strong profile in the technosciences and high aims regarding the global bioeconomy, yet her regulation of human genetics, reproductive medicine and embryo research has for a long time been rather restrictive. German biopolitical exceptionalism has often been explained by reference to Catholicism and the legacy of the Nazi past. The Germans, so goes the common story, have learnt the lessons of history and translated them into unconditional respect for human dignity, which in turn translates into unconditional protection of human life, including the human embryo, and the firm repudiation of any eugenic distinction between 'life worth to live' and 'life not worth to live'. This, however, is not the whole story. Alongside deontological strictness we find another strand of governing body politics and reprogenetics in Germany, the rule-and-exception model, running from the mid-1970s abortion law via the 2002 Stem Cell Act to the 2011 regulation of pre-implantation genetic diagnosis. In contrast to the former, that strongly draws on Kant and his concept of human dignity, the latter bears resemblances to Carl Schmitt's concept of state of exception. The article will show that the rule-and-exception model builds the exception into the rule and transforms the meaning and mandate of ethics, namely from safeguarding ethical standards to deciding about the exception. Given that the exception has now tended to become the rule, the question is whether the lessons of history will govern German reprogenetics for much longer.

  20. BEHAVIORAL RESEARCH ON EXCEPTIONAL CHILDREN.

    ERIC Educational Resources Information Center

    KIRK, SAMUEL A.; WEINER, BLUMA B.

    THIS MONOGRAPH PROVIDES REVIEWS OF BEHAVIORAL RESEARCH STUDIES WHICH INCLUDE AUTHOR, TITLE, PURPOSE, SUBJECTS, METHODS OR PROCEDURES, AND RESULTS. REVIEWS ARE GROUPED BY 11 EXCEPTIONALITY AREAS AND ADMINISTRATION OF SPECIAL EDUCATION. THE AREAS OF EXCEPTIONALITY ARE (1) GIFTED, (2) EDUCABLE MENTALLY RETARDED, (3) TRAINABLE MENTALLY RETARDED, (4)…

  1. A World of Exceptional Children.

    ERIC Educational Resources Information Center

    Conroy, Elizabeth H.; And Others

    This fifth chapter in "Elementary School Counseling in a Changing World" contains four journal articles which focus on exceptional children and helping elementary school counselors build a supportive learning environment for exceptional children. "Primary Prevention for Gifted Students: A Parent Education Group" by Elizabeth Conroy describes a…

  2. The Muslim festival of Eid ul-Fitr at L'Arche Daybreak: a pattern and principles for common worship services in solidarity with those not of the majority faith.

    PubMed

    Porter, B

    2001-01-01

    Describes a common worship pattern designed to include a Muslim woman but a pattern that could be readily adapted in many situations of community or institutional chaplaincy settings where one or more of the members or residents is not of the majority religion.

  3. Discovery of A New Retrograde Trans-Neptunian Object: Hint of A Common Orbital Plane for Low Semi-Major Axis, High Inclination TNOs and Centaurs

    NASA Astrophysics Data System (ADS)

    Chen, Ying-Tung; Lin, Hsing-Wen; Holman, Matthew J.; Payne, Matthew John; Fraser, Wesley Cristopher; Lacerda, Pedro; Ip, Wing-Huen; Pan-STARRS 1 Builders

    2016-10-01

    The origin of high inclination objects beyond Jupiter, including trans-Neptunian objects (TNOs) and Centaurs, remains uncertain. We report the discovery of a retrograde TNO, which we nickname "Niku", detected by the Pan-STARRS 1 Outer Solar System Survey. The numerical integrations show that the orbital dynamics of Niku are very similar to those of 2008 KV42 (Drac), with a half-life of ~ 500 Myr and analogous orbital evolution. Comparing similar high inclination members announced by the Minor-Planet Center (q > 10 AU, a < 100 AU and i > 60), we find these objects exhibit a surprising clustering of ascending node, populating a common orbital plane. The statistical significance of 3.8-sigma suggests it is unlikely to be coincidental. An unknown mechanism is required to explain the observed clustering. This discovery may provide a pathway to investigating a possible reservoir of high-inclination objects.

  4. Transcripts of sulphur metabolic genes are co-ordinately regulated in developing seeds of common bean lacking phaseolin and major lectins

    PubMed Central

    Marsolais, Frédéric

    2012-01-01

    The lack of phaseolin and phytohaemagglutinin in common bean (dry bean, Phaseolus vulgaris) is associated with an increase in total cysteine and methionine concentrations by 70% and 10%, respectively, mainly at the expense of an abundant non-protein amino acid, S-methyl-cysteine. Transcripts were profiled between two genetically related lines differing for this trait at four stages of seed development using a high density microarray designed for common bean. Transcripts of multiple sulphur-rich proteins were elevated, several previously identified by proteomics, including legumin, basic 7S globulin, albumin-2, defensin, albumin-1, the Bowman–Birk type proteinase inhibitor, the double-headed trypsin inhibitor, and the Kunitz trypsin inhibitor. A co-ordinated regulation of transcripts coding for sulphate transporters, sulphate assimilatory enzymes, serine acetyltransferases, cystathionine β-lyase, homocysteine S-methyltransferase and methionine gamma-lyase was associated with changes in cysteine and methionine concentrations. Differential gene expression of sulphur-rich proteins preceded that of sulphur metabolic enzymes, suggesting a regulation by demand from the protein sink. Up-regulation of SERAT1;1 and -1;2 expression revealed an activation of cytosolic O-acetylserine biosynthesis. Down-regulation of SERAT2;1 suggested that cysteine and S-methyl-cysteine biosynthesis may be spatially separated in different subcellular compartments. Analysis of free amino acid profiles indicated that enhanced cysteine biosynthesis was correlated with a depletion of O-acetylserine. These results contribute to our understanding of the regulation of sulphur metabolism in developing seed in response to a change in the composition of endogenous proteins. PMID:23066144

  5. An USH2A founder mutation is the major cause of Usher syndrome type 2 in Canadians of French origin and confirms common roots of Quebecois and Acadians

    PubMed Central

    Ebermann, Inga; Koenekoop, Robert K; Lopez, Irma; Bou-Khzam, Lara; Pigeon, Renée; Bolz, Hanno J

    2009-01-01

    Congenital hearing loss affects approximately one child in 1000. About 10% of the deaf population have Usher syndrome (USH). In USH, hearing loss is complicated by retinal degeneration with onset in the first (USH1) or second (USH2) decade. In most populations, diagnostic testing is hampered by a multitude of mutations in nine genes. We have recently shown that in French Canadians from Quebec, USH1 largely results from a single USH1C founder mutation, c.216G>A (‘Acadian allele'). The genetic basis of USH2 in Canadians of French descent, however, has remained elusive. Here, we have investigated nine USH2 families from Quebec and New Brunswick (the former Acadia) by haplotype analyses of the USH2A locus and sequencing of the three known USH2 genes. Seven USH2A mutations were identified in eight patients. One of them, c.4338_4339delCT, accounts for 10 out of 18 disease alleles (55.6%). This mutation has previously been reported in an Acadian USH2 family, and it was found in homozygous state in the three Acadians of our sample. As in the case of c.216G>A (USH1C), a common haplotype is associated with c.4338_4339delCT. With a limited number of molecular tests, it will now be possible in these populations to estimate whether children with congenital hearing impairment of different degrees will develop retinal disease – with important clinical and therapeutic implications. USH2 is the second example that reveals a significant genetic overlap between Quebecois and Acadians: in contrast to current understanding, other genetic disorders present in both populations are likely based on common founder mutations as well. PMID:18665195

  6. Transcripts of sulphur metabolic genes are co-ordinately regulated in developing seeds of common bean lacking phaseolin and major lectins.

    PubMed

    Liao, Dengqun; Pajak, Agnieszka; Karcz, Steven R; Chapman, B Patrick; Sharpe, Andrew G; Austin, Ryan S; Datla, Raju; Dhaubhadel, Sangeeta; Marsolais, Frédéric

    2012-10-01

    The lack of phaseolin and phytohaemagglutinin in common bean (dry bean, Phaseolus vulgaris) is associated with an increase in total cysteine and methionine concentrations by 70% and 10%, respectively, mainly at the expense of an abundant non-protein amino acid, S-methyl-cysteine. Transcripts were profiled between two genetically related lines differing for this trait at four stages of seed development using a high density microarray designed for common bean. Transcripts of multiple sulphur-rich proteins were elevated, several previously identified by proteomics, including legumin, basic 7S globulin, albumin-2, defensin, albumin-1, the Bowman-Birk type proteinase inhibitor, the double-headed trypsin inhibitor, and the Kunitz trypsin inhibitor. A co-ordinated regulation of transcripts coding for sulphate transporters, sulphate assimilatory enzymes, serine acetyltransferases, cystathionine β-lyase, homocysteine S-methyltransferase and methionine gamma-lyase was associated with changes in cysteine and methionine concentrations. Differential gene expression of sulphur-rich proteins preceded that of sulphur metabolic enzymes, suggesting a regulation by demand from the protein sink. Up-regulation of SERAT1;1 and -1;2 expression revealed an activation of cytosolic O-acetylserine biosynthesis. Down-regulation of SERAT2;1 suggested that cysteine and S-methyl-cysteine biosynthesis may be spatially separated in different subcellular compartments. Analysis of free amino acid profiles indicated that enhanced cysteine biosynthesis was correlated with a depletion of O-acetylserine. These results contribute to our understanding of the regulation of sulphur metabolism in developing seed in response to a change in the composition of endogenous proteins.

  7. 76 FR 78316 - Excepted Service

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-16

    ... From the Federal Register Online via the Government Publishing Office OFFICE OF PERSONNEL MANAGEMENT Excepted Service AGENCY: U.S. Office of Personnel Management (OPM). ACTION: Notice. SUMMARY: This... Personnel Management. John Berry, Director. BILLING CODE 6325-39-P...

  8. Mapping of major diseases and devising prevention and control regimen to common diseases in cattle and shoats in Dassenech district of South Omo Zone, South-Western Ethiopia.

    PubMed

    Molla, Bereket; Delil, Faris

    2015-01-01

    Livestock production system, particularly in pastoral areas, is mainly constrained by rampant livestock diseases and seasonal feed and water shortages. In areas like Dassenech, bordering Kenya and South Sudan, this risks are pronounced due to the unavailability of appropriate prevention and control. The research was conducted with the objectives of identifying major rampant diseases and designing appropriate prevention and control strategies. A cross-sectional study was employed, conducted using both participatory epidemiology and conventional veterinary investigation. Spatial and temporal occurrence of diseases was assessed. The major five diseases in bovine were contagious bovine pleuro pneumonia (CBPP), septicemic pasteurellosis, anthrax, foot and mouth disease (FMD), and black leg, in that order of importance. Similarly, in ovine, "unknown recent disease," pneumonic pasteurellosis, brucellosis, peste des petits ruminants (PPR), and septicemic pasteurellosis were ranked, starting from the most important whereas in caprine PPR, contagious caprine pleuro pneumonia (CCPP), goat pox, brucellosis, and pneumonic pasteurellosis were ranked in that order of importance. The seroprevalence in bovine were found to be 97, 10, 18, and 15% for septicemic pasteurelosis, CBPP, FMD, and brucellosis, respectively. The seroprevalence of septicemic pasteurelosis, PPR, and brucellosis was 86, 49, and 3%, respectively, in ovine. The seroprevalence of caprine sera for CCPP, PPR, and brucellosis were 87, 42, and 0%, respectively. The prevention and control regimen, vaccination against CBPP, should be at the beginning of wet season, whereas, for FMD, it should be at the end of wet season in bovine. Brucellosis for bovine, if has to be applied, should be at the beginning of dry season. PPR vaccination for ovine should be at the beginning of wet season whereas, for caprine, it should be just before start of dry season. Furthermore, the efficacy of aforementioned vaccines and its protocol

  9. The X-Factor: an evaluation of common methods used to analyse major inter-segment kinematics during the golf swing.

    PubMed

    Brown, Susan J; Selbie, W Scott; Wallace, Eric S

    2013-01-01

    A common biomechanical feature of a golf swing, described in various ways in the literature, is the interaction between the thorax and pelvis, often termed the X-Factor. There is no consistent method used within golf biomechanics literature however to calculate these segment interactions. The purpose of this study was to examine X-factor data calculated using three reported methods in order to determine the similarity or otherwise of the data calculated using each method. A twelve-camera three-dimensional motion capture system was used to capture the driver swings of 19 participants and a subject specific three-dimensional biomechanical model was created with the position and orientation of each model estimated using a global optimisation algorithm. Comparison of the X-Factor methods showed significant differences for events during the swing (P < 0.05). Data for each kinematic measure were derived as a times series for all three methods and regression analysis of these data showed that whilst one method could be successfully mapped to another, the mappings between methods are subject dependent (P <0.05). Findings suggest that a consistent methodology considering the X-Factor from a joint angle approach is most insightful in describing a golf swing.

  10. Inhibition of Major Drug Metabolizing CYPs by Common Herbal Medicines used by HIV/AIDS Patients in Africa– Implications for Herb-Drug Interactions

    PubMed Central

    Awortwe, Charles; Bouic, Patrick J.; Masimirembwa, Collen M.; Rosenkranz, Bernd

    2015-01-01

    The purpose of this study was to evaluate the potential risk of common herbal medicines used by HIV-infected patients in Africa for herb-drug interactions (HDI). High throughput screening assays consisting of recombinant Cytochrome P450 enzymes (CYPs) and fluorescent probes, and parallel artificial membrane permeability assays (PAMPA) were used. The potential of herbal medicines to cause HDI was ranked according to FDA guidelines for reversible inhibition and categorization of time dependent inhibition was based on the normalized ratio. CYPs 1A2 and 3A4 were most inhibited by the herbal extracts. H. hemerocallidea (IC50 = 0.63 μg/mL and 58 μg/mL) and E. purpurea (IC50 = 20 μg/mL and 12 μg/mL) were the potent inhibitors of CYPs 1A2 and 3A4 respectively. L. frutescens and H. hemerocallidea showed clear time dependent inhibition on CYP3A4. Furthermore, the inhibitory effect of both H. hemerocallidea and L. frutescens before and after PAMPA were identical. The results indicate potential HDI of H. hemerocallidea, L. frutescens and E. purpurea with substrates of the affected enzymes if maximum in vivo concentration is achieved. PMID:24475926

  11. Tryptophan kynurenine metabolism as a common mediator of genetic and environmental impacts in major depressive disorder: the serotonin hypothesis revisited 40 years later.

    PubMed

    Oxenkrug, Gregory F

    2010-01-01

    The original 1969 Lancet paper proposed in depression the activity of liver tryptophan-pyrrolase is stimulated by raised blood corticosteroids levels, and metabolism of tryptophan is shunted away from serotonin production, and towards kynurenine production. Discovery of neurotropic activity of kynurenines suggested that up-regulation of the tryptophan-kynurenine pathway not only augmented serotonin deficiency but also underlined depression-associated anxiety, psychosis and cognitive decline. The present review of genetic and hormonal factors regulating kynurenine pathway of tryptophan metabolism suggests that this pathway mediates both genetic and environmental mechanisms of depression. Rate-limiting enzymes of kynurenine formation, tryptophan 2,3-dioxygenase (TDO) and indoleamine 2,3-dioxygenase (IDO) are activated by stress hormones (TDO) and/or by pro-inflammatory cytokines (IDO). Simultaneous presence of high producers alleles of proinflammatory cytokines genes (e.g., interferon-gamma and tumor necrosis factor-alpha) determines the genetic predisposition to depression via up-regulation of IDO while impact of environmental stresses is mediated via hormonal activation of TDO. Tryptophan-kynurenine pathway represents a major meeting point of gene-environment interaction in depression and a new target for pharmacological intervention.

  12. Major Contribution of Flowering Time and Vegetative Growth to Plant Production in Common Bean As Deduced from a Comparative Genetic Mapping.

    PubMed

    González, Ana M; Yuste-Lisbona, Fernando J; Saburido, Soledad; Bretones, Sandra; De Ron, Antonio M; Lozano, Rafael; Santalla, Marta

    2016-01-01

    Determinacy growth habit and accelerated flowering traits were selected during or after domestication in common bean. Both processes affect several presumed adaptive traits such as the rate of plant production. There is a close association between flowering initiation and vegetative growth; however, interactions among these two crucial developmental processes and their genetic bases remain unexplored. In this study, with the aim to establish the genetic relationships between these complex processes, a multi-environment quantitative trait locus (QTL) mapping approach was performed in two recombinant inbred line populations derived from inter-gene pool crosses between determinate and indeterminate genotypes. Additive and epistatic QTLs were found to regulate flowering time, vegetative growth, and rate of plant production. Moreover, the pleiotropic patterns of the identified QTLs evidenced that regions controlling time to flowering traits, directly or indirectly, are also involved in the regulation of plant production traits. Further QTL analysis highlighted one QTL, on the lower arm of the linkage group Pv01, harboring the Phvul.001G189200 gene, homologous to the Arabidopsis thaliana TERMINAL FLOWER1 (TFL1) gene, which explained up to 32% of phenotypic variation for time to flowering, 66% for vegetative growth, and 19% for rate of plant production. This finding was consistent with previous results, which have also suggested Phvul.001G189200 (PvTFL1y) as a candidate gene for determinacy locus. The information here reported can also be applied in breeding programs seeking to optimize key agronomic traits, such as time to flowering, plant height and an improved reproductive biomass, pods, and seed size, as well as yield.

  13. Major Contribution of Flowering Time and Vegetative Growth to Plant Production in Common Bean As Deduced from a Comparative Genetic Mapping

    PubMed Central

    González, Ana M.; Yuste-Lisbona, Fernando J.; Saburido, Soledad; Bretones, Sandra; De Ron, Antonio M.; Lozano, Rafael; Santalla, Marta

    2016-01-01

    Determinacy growth habit and accelerated flowering traits were selected during or after domestication in common bean. Both processes affect several presumed adaptive traits such as the rate of plant production. There is a close association between flowering initiation and vegetative growth; however, interactions among these two crucial developmental processes and their genetic bases remain unexplored. In this study, with the aim to establish the genetic relationships between these complex processes, a multi-environment quantitative trait locus (QTL) mapping approach was performed in two recombinant inbred line populations derived from inter-gene pool crosses between determinate and indeterminate genotypes. Additive and epistatic QTLs were found to regulate flowering time, vegetative growth, and rate of plant production. Moreover, the pleiotropic patterns of the identified QTLs evidenced that regions controlling time to flowering traits, directly or indirectly, are also involved in the regulation of plant production traits. Further QTL analysis highlighted one QTL, on the lower arm of the linkage group Pv01, harboring the Phvul.001G189200 gene, homologous to the Arabidopsis thaliana TERMINAL FLOWER1 (TFL1) gene, which explained up to 32% of phenotypic variation for time to flowering, 66% for vegetative growth, and 19% for rate of plant production. This finding was consistent with previous results, which have also suggested Phvul.001G189200 (PvTFL1y) as a candidate gene for determinacy locus. The information here reported can also be applied in breeding programs seeking to optimize key agronomic traits, such as time to flowering, plant height and an improved reproductive biomass, pods, and seed size, as well as yield. PMID:28082996

  14. Hsp70 and small Hsps are the major heat shock protein members involved in midgut metamorphosis in the common cutworm, Spodoptera litura.

    PubMed

    Gu, J; Huang, L-X; Shen, Y; Huang, L-H; Feng, Q-L

    2012-10-01

    Heat shock proteins (Hsps) are important chaperones, which are involved in various signal pathways and regulate lots of physiological processes. Early research suggested that some Hsps are involved in insect development. However, few studies have been carried out to explore the roles of Hsps, especially in larval-pupal metamorphosis. In the present study, 49 Hsp unigenes were identified in the Spodoptera litura transcriptome and their mRNA expression profiles during midgut metamorphosis were examined using a tag-based digital gene expression system. The genes with the most different levels of expression were then cloned and their expression patterns in midguts from sixth instar larvae to pupae were analysed using real time quantitative PCR. The responses of these genes to juvenile hormone (JH) and 20-hydroxyecdysone (20E) were also studied. The results showed that the mRNA levels of 22 Hsp unigenes changed significantly during midgut metamorphosis. Amongst these 22 unigenes, hsp70, hsp20.4 and hsp20.8 were the most up-regulated members, and hsp15.9, hsp19.3 and hsp22.0 were the most down-regulated ones. Further studies showed that hsp70, hsp20.4 and hsp20.8 were remarkably up-regulated by JH. In addition, 20E slightly increased the mRNA levels of both hsp20.4 and hsp20.8. However, hsp15.9, hsp19.3 and hsp22.0 did not respond to either JH or 20E. These results indicate that Hsp70 and small Hsps (sHsps) are probably the major players in midgut metamorphosis in S. litura. The current findings provide valuable insights into the roles of the Hsp superfamily in insect metamorphosis.

  15. Hypotonicity-activated efflux of taurine and myo-inositol in rat inner medullary collecting duct cells: evidence for a major common pathway.

    PubMed

    Ruhfus, B; Kinne, R K

    1996-01-01

    To further characterize the hypotonicity-activated efflux pathways for the organic osmolytes taurine and myo-inositol in inner medullary collecting duct (IMCD) cells tracer fluxes of taurine and myo-inositol were investigated. The time course of activation of both fluxes after exposure of cells isolated at 600 mosm to a hypotonic medium (300 mosm by omission of sucrose) was identical with a major increase of release within the first 10 min. All 'anion channel blockers' employed proved to be strong inhibitors of both fluxes. Inhibition of myo-inositol efflux by 0.5 mM NPPB and 0.1 mM dideoxyforskolin was not significantly different from that of taurine efflux (87.7 +/- 11.4 compared to 94.6 +/- 4.6% and 98.8 +/- 2.0 compared to 95.9 +/- 3.7%). However, SITS (0.5 and 0.01 mM), DIDS (0.5 and 0.01 mM), and niflumic acid (0.5 mM) inhibited myo-inositol efflux more strongly than taurine efflux. The respective values were 65.4 +/- 4 vs. 42.9 +/- 3.6% for 0.01 mM SITS, 65.7 +/- 4.2 vs. 45.8 +/- 2.0% for 0.01 mM DIDS, and 79.5 +/- 3.5 vs. 54.2 +/- 2.5% for 0.5 mM niflumic acid. Taurine as well as myo-inositol efflux were decreased to a similar extent by 10 mM extracellular ATP (26.9 +/- 6.3 vs. 29.8 +/- 17.7% inhibition), by 10 mM extracellular cAMP (52.8 +/- 9.8 vs. 60.1 +/- 17.2% inhibition) and by reduction of the intracellular ATP content employing 2-deoxy-D-glucose (31.9 +/- 5.9 vs. 40.4 +/- 13.6% inhibition). In polarized primary cell cultures taurine and myo-inositol were released during a hypotonic shock primarily across the basal-lateral membrane, the ratio of basolateral versus apical efflux was 4.1 for taurine and 3.9 for myo-inositol. Apical fluxes were more sensitive to 0.01 mM SITS or DIDS; this was particularly evident for apical myo-inositol efflux which was inhibited by 0.01 mM SITS by 84.1 +/- 5.9% compared to 43.5 +/- 13.1% inhibition of the basolateral efflux. Thus, taurine and myo-inositol efflux show to a great extent a similar cellular distribution

  16. Gifted Students with Disabilities: "Twice Exceptionality" in the Music Classroom

    ERIC Educational Resources Information Center

    Abramo, Joseph Michael

    2015-01-01

    Many music educators teach students who are both gifted and possess a learning disability--what is commonly referred to as "twice exceptionality." This article describes some characteristics of twice-exceptional students, the challenges these students often face in school, and some strategies music educators can use to properly…

  17. Gifted Students with Disabilities: "Twice Exceptionality" in the Music Classroom

    ERIC Educational Resources Information Center

    Abramo, Joseph Michael

    2015-01-01

    Many music educators teach students who are both gifted and possess a learning disability--what is commonly referred to as "twice exceptionality." This article describes some characteristics of twice-exceptional students, the challenges these students often face in school, and some strategies music educators can use to properly…

  18. Major depression.

    PubMed

    Bentley, Susan M; Pagalilauan, Genevieve L; Simpson, Scott A

    2014-09-01

    Major depression is a common, disabling condition seen frequently in primary care practices. Non-psychiatrist ambulatory providers are increasingly responsible for diagnosing, and primarily managing patients suffering from major depressive disorder (MDD). The goal of this review is to help primary care providers to understand the natural history of MDD, identify practical tools for screening, and a thoughtful approach to management. Clinically challenging topics like co-morbid conditions, treatment resistant depression and pharmacotherapy selection with consideration to side effects and medication interactions, are also covered.

  19. Collaborative care documentation by exception system.

    PubMed Central

    Ashworth, G. B.; Aubrey, C.

    1992-01-01

    Development of a workstation-based documentation system supporting collaborative care and nurse charting by exception has been underway for the last two and one-half years at Vanderbilt University Medical Center in Nashville, Tennessee. The Pathways system has undergone two major revisions and is currently implemented on three nursing units. The system supports collaborative care by providing a mechanism for entry and printing of collaborative care pathways and collection of exception data. Paper flowsheets for manual charting are generated based on the patient's collaborative pathway and individual needs. The Pathways system has significantly decreased nursing time and effort for documentation. This paper describes the development, implementation, and impact of the workstation-based documentation system. PMID:1482850

  20. Autism: Exceptional Child Bibliography Series.

    ERIC Educational Resources Information Center

    Council for Exceptional Children, Reston, VA. Information Center on Exceptional Children.

    One in a series of over 50 similar selected listings, the bibliography contains 47 items of research reports, conference papers, journal articles, texts, and program guides selected from "Exceptional Child Education Abstracts". Each entry on autism provides bibliographical data, availability information, indexing and retrieval descriptors, and…

  1. An exception to court rule

    SciTech Connect

    Black, B.; Strott, L.

    1995-01-01

    In August, 1994, the U.S. Court of Appeals for the 3rd Circuit handed down a decision that could make it much easier to challenge Superfund remedies in court. The Superfund law explicitly limits judicial review of removal or remedial actions. There are five exceptions to the above which are described in this paper.

  2. Exceptional cognitive ability: the phenotype.

    PubMed

    Lubinski, David

    2009-07-01

    Characterizing the outcomes related to the phenotype of exceptional cognitive abilities has been feasible in recent years due to the availability of large samples of intellectually precocious adolescents identified by modern talent searches that have been followed-up longitudinally over multiple decades. The level and pattern of cognitive abilities, even among participants within the top 1% of general intellectual ability, are related to differential developmental trajectories and important life accomplishments: The likelihood of earning a doctorate, earning exceptional compensation, publishing novels, securing patents, and earning tenure at a top university (and the academic disciplines within which tenure is most likely to occur) all vary as a function of individual differences in cognitive abilities assessed decades earlier. Individual differences that distinguish the able (top 1 in 100) from the exceptionally able (top 1 in 10,000) during early adolescence matter in life, and, given the heritability of general intelligence, they suggest that understanding the genetic and environmental origins of exceptional abilities should be a high priority for behavior genetic research, especially because the results for extreme groups could differ from the rest of the population. In addition to enhancing our understanding of the etiology of general intelligence at the extreme, such inquiry may also reveal fundamental determinants of specific abilities, like mathematical versus verbal reasoning, and the distinctive phenotypes that contrasting ability patterns are most likely to eventuate in at extraordinary levels.

  3. 75 FR 52376 - Excepted Service

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-25

    ... [Federal Register Volume 75, Number 164 (Wednesday, August 25, 2010)] [Notices] [Pages 52376-52377] [FR Doc No: 2010-21069] OFFICE OF PERSONNEL MANAGEMENT Excepted Service AGENCY: U.S. Office of.... 218. John Berry, Director, U.S. Office of Personnel Management. [FR Doc. 2010-21069 Filed 8-24-10;...

  4. Calendrical Savants: Exceptionality and Practice

    ERIC Educational Resources Information Center

    Cowan, Richard; Carney, Daniel P. J.

    2006-01-01

    The exceptionality of the skills of calendrical savants and the role of practice were investigated. Experiment 1 compared four autistic calendrical savants to Professor Conway, a distinguished mathematician with calendrical skills. Professor Conway answered questions over a greater range of years but some savants knew more calendrical…

  5. Grading Exceptional and Struggling Learners

    ERIC Educational Resources Information Center

    Jung, Lee Ann; Guskey, Thomas R.

    2011-01-01

    How can you ensure that you are grading your exceptional students fairly? Teachers receive very little guidance for grading students with disabilities, English learners, and those receiving services through a response-to-intervention (RTI) process. This practitioner-friendly book provides teachers and administrators with an effective framework for…

  6. 77 FR 41458 - Excepted Service

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-13

    ... MANAGEMENT Excepted Service AGENCY: U.S. Office of Personnel Management (OPM). ACTION: Notice. SUMMARY: This... BO120021 03/30/2012 Assistant. Office of Personnel Management.... Planning and Policy Deputy Performance... Personnel Management. John Berry, Director. BILLING CODE 6325-39-P...

  7. 76 FR 13241 - Excepted Service

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-10

    ... From the Federal Register Online via the Government Publishing Office OFFICE OF PERSONNEL MANAGEMENT Excepted Service AGENCY: U.S. Office of Personnel Management (OPM). ACTION: Notice. SUMMARY: This... Management. Director, Office of DE110016 1/5/2011 Scheduling and Advance. ] Office of the Special...

  8. 76 FR 21411 - Excepted Service

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-15

    ... From the Federal Register Online via the Government Publishing Office OFFICE OF PERSONNEL MANAGEMENT Excepted Service AGENCY: U.S. Office of Personnel Management (OPM). ACTION: Notice. SUMMARY: This...; E.O. 10577, 3 CFR 1954-1958 Comp., p. 218. John Berry, Director, U.S. Office of Personnel...

  9. 78 FR 28652 - Excepted Service

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-15

    ... MANAGEMENT Excepted Service AGENCY: U.S. Office of Personnel Management (OPM). ACTION: Notice. SUMMARY: This... the Office of Personnel Management (OPM) publishes a notice of agency-specific authorities established... 3302; E.O. 10577, 3 CFR, 1954-1958 Comp., p. 218. U.S. Office of Personnel Management. Elaine...

  10. An Investigation of Exceptional Twins.

    ERIC Educational Resources Information Center

    Crismore, Avon

    The author, herself a mother of twins, reviews research on exceptional twins. She considers reasons for fascination with twins and comments upon important advances in technology. Current research in Indianapolis to measure cognitive, perceptual, personality, and chromosome patterns of twins is described. Differences in the makeup of identical and…

  11. No Common Opinion on the Common Core

    ERIC Educational Resources Information Center

    Henderson, Michael B.; Peterson, Paul E.; West, Martin R.

    2015-01-01

    According to the three authors of this article, the 2014 "EdNext" poll yields four especially important new findings: (1) Opinion with respect to the Common Core has yet to coalesce. The idea of a common set of standards across the country has wide appeal, and the Common Core itself still commands the support of a majority of the public.…

  12. Exceptional fossil preservation and the cambrian explosion.

    PubMed

    Butterfield, Nicholas J

    2003-02-01

    Exceptionally preserved, non-biomineralizing fossils contribute importantly to resolving details of the Cambrian explosion, but little to its overall patterns. Six distinct "types" of exceptional preservation are identified for the terminal Proterozoic-Cambrian interval, each of which is dependent on particular taphonomic circumstances, typically restricted both in space and time. Taphonomic pathways yielding exceptional preservation were particularly variable through the Proterozoic-Cambrian transition, at least in part a consequence of contemporaneous evolutionary innovations. Combined with the reasonably continuous record of "Doushantuo-type preservation," and the fundamentally more robust records of shelly fossils, phytoplankton cysts and trace fossils, these taphonomic perturbations contribute to the documentation of major evolutionary and biogeochemical shifts through the terminal Proterozoic and early Cambrian.Appreciation of the relationship between taphonomic pathway and fossil expression serves as a useful tool for interpreting exceptionally preserved, often problematic, early Cambrian fossils. In shale facies, for example, flattened non-biomineralizing structures typically represent the remains of degradation-resistant acellular and extracellular "tissues" such as chaetae and cuticles, whereas three-dimensional preservation represents labile cellular tissues with a propensity for attracting and precipitating early diagenetic minerals. Such distinction helps to identify the acuticular integument of hyolithids, the chaetae-like nature of Wiwaxia sclerites, the chaetognath-like integument of Amiskwia, the midgut glands of various Burgess Shale arthropods, and the misidentification of deposit-feeding arthropods in the Chengjiang biota. By the same reasoning, putative lobopods in the Sirius Passet biota and putative deuterostomes in the Chengiang biota are better interpreted as arthropods.

  13. Major cytoplasmic membrane protein of Legionella pneumophila, a genus common antigen and member of the hsp 60 family of heat shock proteins, induces protective immunity in a guinea pig model of Legionnaires' disease.

    PubMed Central

    Blander, S J; Horwitz, M A

    1993-01-01

    We have examined the capacity of the major cytoplasmic membrane protein (MCMP) of Legionella pneumophila, a genus common antigen and member of the hsp 60 family of heat shock proteins, to induce protective immunity in a guinea pig model of Legionnaires' disease. We purified MCMP to homogeneity from L. pneumophila by buffer extraction, ion-exchange chromatography, and molecular sieve chromatography. Guinea pigs immunized with MCMP developed a strong cell-mediated immune response to the immunogen manifest by marked cutaneous delayed-type hypersensitivity. Guinea pigs immunized with MCMP and then challenged with a lethal aerosol dose of L. pneumophila exhibited a high level of protective immunity. Altogether, in four independent experiments, 55 of 64 (86%) animals immunized three times with 0.6-40 micrograms MCMP including 11 of 11 (100%) animals immunized three times with 40 micrograms MCMP survived aerosol challenge with L. pneumophila compared with 1 of 29 (3%) sham-immunized control animals (P < 0.0001, Cochran-Mantel-Haenszel X2 statistic for pooled data). To our knowledge, MCMP is the first member of the hsp 60 family of proteins shown to induce protective immunity to a microbial pathogen. MCMP has potential as a vaccine against Legionnaires' disease. Since MCMP is a genus common antigen, vaccination with a combination of MCMPs derived from different Legionella species has the potential of inducing protective immunity against all the major Legionella species causing human disease. Images PMID:8432872

  14. Insecticidal activity of an essential oil of Tagetes patula L. (Asteraceae) on common bed bug Cimex lectularius L. and molecular docking of major compounds at the catalytic site of ClAChE1.

    PubMed

    Politi, Flávio Augusto Sanches; Nascimento, Juliana Damieli; da Silva, Alexander Alves; Moro, Isabela Jacob; Garcia, Mariana Lopes; Guido, Rafael Victório Carvalho; Pietro, Rosemeire Cristina Linhari Rodrigues; Godinho, Antônio Francisco; Furlan, Maysa

    2017-01-01

    Emerging resistance to insecticides has influenced pharmaceutical research and the search for alternatives to control the common bed bug Cimex lectularius. In this sense, natural products can play a major role. Tagetes patula, popularly known as dwarf marigold, is a plant native to North America with biocide potential. The aim of this work was to evaluate the biological activity of T. patula essential oil (EO) against adult common bed bugs via exposure to dry residues by the Impregnated Paper Disk Test (IPDT) using cypermethrin as a positive control. We selected the enzyme acetylcholinesterase as a target for modeling studies, with the intent of investigating the molecular basis of any biological activity of the EO. Chemical analysis of the EO was performed using gas chromatography coupled to mass spectrometry (GC-MS). Additionally, oral and dermal acute toxicity tests were performed according to Organization for Economic Cooperation and Development (OECD) guidelines. The sulforhodamine B assay (SRB) was performed to verify the cytotoxicity of EO to HaCaT cells. The EO eliminated 100 % of the bed bugs at 100 mg mL(-1) with an LC50 value of 15.85 mg mL(-1). GC-MS analysis identified α-terpinolene, limonene, piperitenone, and piperitone as major components of the mixture. Molecular modeling studies of these major compounds suggested that they are acetylcholinesterase inhibitors with good steric and electronic complementarity. The in vitro cytotoxicity evaluation revealed a LC50 = 37.06 μg mL(-1) and in vivo acute toxicity showed an LC50 >4000 mg kg(-1), indicating that the EO presents low risk of toxic side effects in humans. The T. patula essential oil components provide a promising strategy for controlling bed bug populations with low mammalian toxicity. These findings pave the way for further in vivo studies aimed at developing a safe and effective insecticide.

  15. Familial Risk for Exceptional Longevity

    PubMed Central

    Sebastiani, Paola; Andersen, Stacy L.; McIntosh, Avery I.; Nussbaum, Lisa; Stevenson, Meredith D.; Pierce, Leslie; Xia, Samantha; Salance, Kelly; Perls, Thomas T.

    2015-01-01

    One of the most glaring deficiencies in the current assessment of mortality risk is the lack of information concerning the impact of familial longevity. In this work, we update estimates of sibling relative risk of living to extreme ages using data from more than 1,700 sibships, and we begin to examine the trend for heritability for different birth-year cohorts. We also build a network model that can be used to compute the increased chance for exceptional longevity of a subject, conditional on his family history of longevity. The network includes familial longevity from three generations and can be used to understand the effects of paternal and maternal longevity on an individual's chance to live to an extreme age. PMID:27041978

  16. Chiral exceptional points in metasurfaces

    NASA Astrophysics Data System (ADS)

    Kang, Ming; Chen, Jing; Chong, Y. D.

    2016-09-01

    An exceptional point (EP) is a degeneracy occurring in a non-energy-conserving system, in which two eigenvectors of a non-Hermitian Hamiltonian coalesce. We explore how EPs can be realized in a metamaterial surface, or metasurface, consisting of a pair of lossy coupled linear antennas in each unit cell. EPs appear in the eigenvectors of the transmission matrix by tuning the frequency and the coupling and loss rates of the metasurface. Each EP is associated with the appearance of a circularly polarized transmission eigenstate; hence, within the parameter space of the system, the EPs lie along pairs of curves with distinct chirality. Our results are obtained using finite-difference time-domain simulations, as well as a fitted coupled-mode theory. The coupled-mode theory agrees well with the numerical results and is capable of accurately predicting the EP f curves.

  17. Familial Risk for Exceptional Longevity.

    PubMed

    Sebastiani, Paola; Andersen, Stacy L; McIntosh, Avery I; Nussbaum, Lisa; Stevenson, Meredith D; Pierce, Leslie; Xia, Samantha; Salance, Kelly; Perls, Thomas T

    2016-01-01

    One of the most glaring deficiencies in the current assessment of mortality risk is the lack of information concerning the impact of familial longevity. In this work, we update estimates of sibling relative risk of living to extreme ages using data from more than 1,700 sibships, and we begin to examine the trend for heritability for different birth-year cohorts. We also build a network model that can be used to compute the increased chance for exceptional longevity of a subject, conditional on his family history of longevity. The network includes familial longevity from three generations and can be used to understand the effects of paternal and maternal longevity on an individual's chance to live to an extreme age.

  18. A comparative study of the role of the major proteinases of germinated common bean (Phaseolus vulgaris L.) and soybean (Glycine max (L.) Merrill) seeds in the degradation of their storage proteins.

    PubMed

    Zakharov, A; Carchilan, M; Stepurina, T; Rotari, V; Wilson, K; Vaintraub, I

    2004-10-01

    Two types of cysteine proteases, low-specificity enzymes from the papain family and Asn-specific from the legumain family are generally considered to be the major endopeptidases responsible for the degradation of seed storage proteins during early seedling growth. The action of the corresponding enzymes (CPPh1 and LLP, respectively) from common bean (Phaseolus vulgaris L.) on phaseolin (the common bean storage protein), and on the homologous soybean (Glycine max (L.) Merrill) storage protein, beta-conglycinin, was studied. Under the action of LLP, proteolysis of phaseolin was limited to cleavage of its interdomain linker. No cleavage of the interdomain linker occurred in beta-conglycinin with LLP. LLP action was restricted to splitting off the disordered N-terminal extensions of alpha and alpha' subunits. No extensive hydrolysis (degradation to short TCA-soluble peptides) of either protein occurred under the action of LLP. CPPh1 cleaved the phaseolin subunits into roughly half-sized fragments at the onset of proteolysis. The cleavage was accompanied by a small (8-10%) decrease of protein. No decrease of protein occurred with further incubation. Thus the two most active proteinases detected in common bean seedlings individually were incapable of the extensive degradation of phaseolin. Extensive hydrolysis of phaseolin was only achieved by the consecutive action of LLP and CPPh1. Similar cleavages occurred during the action of CPPh1 on beta-conglycinin. However, by contrast with phaseolin, CPPh1 by itself accomplished the extensive hydrolysis of beta-conglycinin. The differences in the course of proteolysis of the proteins studied were determined by their structural peculiarities.

  19. Social determinants of common metabolic risk factors (high blood pressure, high blood sugar, high body mass index and high waist-hip ratio) of major non-communicable diseases in South Asia region: a systematic review protocol.

    PubMed

    Sharma, Sudesh Raj; Mishra, Shiva Raj; Wagle, Kusum; Page, Rachel; Matheson, Anna; Lambrick, Danielle; Faulkner, James; Lounsbury, David; Vaidya, Abhinav

    2017-09-07

    Prevalence of non-communicable diseases has been increasing at a greater pace in developing countries and, in particular, the South Asia region. Various behavioral, social and environmental factors present in this region perpetuate common metabolic risk factors of non-communicable diseases. This study will identify social determinants of common metabolic risk factors of major non-communicable diseases in the context of the South Asian region and map their causal pathway. A systematic review of selected articles will be carried out following Cochrane guidelines. Review will be guided by Social Determinants of Health Framework developed by the World Health Organization to extract social determinants of metabolic risk factors of non-communicable diseases from studies. A distinct search strategy will be applied using key words to screen relevant studies from online databases. Primary and grey literature published from the year 2000 to 2016 and studies with discussion on proximal and distal determinants of non-communicable risk factors among adults of the South Asia region will be selected. They will be further checked for quality, and a matrix illustrating contents of selected articles will be developed. Thematic content analysis will be done to trace social determinants and their interaction with metabolic risk factors. Findings will be illustrated in causal loop diagrams with social determinants of risk factors along with their interaction (feedback mechanism). The review will describe the interplay of social determinants of common NCD metabolic risk factors in the form of causal loop diagram. Findings will be structured in two parts: the first part will explain the linkage between proximal determinants with the metabolic risk factors and the second part will describe the linkage among the risk factors, proximal determinants and distal determinants. Evidences across different regions will be discussed to compare and validate and/or contrast the findings. Possible

  20. Common Cold

    MedlinePlus

    ... nose, coughing - everyone knows the symptoms of the common cold. It is probably the most common illness. In ... avoid colds. There is no cure for the common cold. For relief, try Getting plenty of rest Drinking ...

  1. 48 CFR 1325.103 - Exceptions.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... FOREIGN ACQUISITION Buy American Act-Supplies 1325.103 Exceptions. (a) The designee authorized to make a... has an agreement with a foreign government providing a blanket exception to the Buy America Act is set...

  2. Exceptional Events Submissions Table (2016 Rule)

    EPA Pesticide Factsheets

    This table contains examples of air agency submitted exceptional events demonstrations and responsive EPA decision documents that have been prepared and/or acted upon under the 2016 Exceptional Events Rule

  3. 48 CFR 1325.103 - Exceptions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... FOREIGN ACQUISITION Buy American Act-Supplies 1325.103 Exceptions. (a) The designee authorized to make a... has an agreement with a foreign government providing a blanket exception to the Buy America Act is...

  4. 45 CFR 670.7 - Food exception.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 45 Public Welfare 3 2011-10-01 2011-10-01 false Food exception. 670.7 Section 670.7 Public Welfare... ANIMALS AND PLANTS Prohibited Acts, Exceptions § 670.7 Food exception. Paragraph (e) of § 670.4 shall not apply to the introduction of animals and plants into Antarctica for use as food as long as animals and...

  5. 45 CFR 670.7 - Food exception.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 3 2010-10-01 2010-10-01 false Food exception. 670.7 Section 670.7 Public Welfare... ANIMALS AND PLANTS Prohibited Acts, Exceptions § 670.7 Food exception. Paragraph (e) of § 670.4 shall not apply to the introduction of animals and plants into Antarctica for use as food as long as animals and...

  6. 45 CFR 670.7 - Food exception.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 45 Public Welfare 3 2012-10-01 2012-10-01 false Food exception. 670.7 Section 670.7 Public Welfare... ANIMALS AND PLANTS Prohibited Acts, Exceptions § 670.7 Food exception. Paragraph (e) of § 670.4 shall not apply to the introduction of animals and plants into Antarctica for use as food as long as animals...

  7. 45 CFR 670.7 - Food exception.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 45 Public Welfare 3 2013-10-01 2013-10-01 false Food exception. 670.7 Section 670.7 Public Welfare... ANIMALS AND PLANTS Prohibited Acts, Exceptions § 670.7 Food exception. Paragraph (e) of § 670.4 shall not apply to the introduction of animals and plants into Antarctica for use as food as long as animals...

  8. 45 CFR 670.7 - Food exception.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 45 Public Welfare 3 2014-10-01 2014-10-01 false Food exception. 670.7 Section 670.7 Public Welfare... ANIMALS AND PLANTS Prohibited Acts, Exceptions § 670.7 Food exception. Paragraph (e) of § 670.4 shall not apply to the introduction of animals and plants into Antarctica for use as food as long as animals...

  9. 22 CFR 506.7 - Exceptions.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 22 Foreign Relations 2 2011-04-01 2009-04-01 true Exceptions. 506.7 Section 506.7 Foreign Relations BROADCASTING BOARD OF GOVERNORS PART-TIME CAREER EMPLOYMENT PROGRAM § 506.7 Exceptions. The Director of the Board and the Associate Director for Management may except positions from inclusion in...

  10. 22 CFR 506.7 - Exceptions.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 2 2010-04-01 2010-04-01 true Exceptions. 506.7 Section 506.7 Foreign Relations BROADCASTING BOARD OF GOVERNORS PART-TIME CAREER EMPLOYMENT PROGRAM § 506.7 Exceptions. The Director of the Board and the Associate Director for Management may except positions from inclusion in...

  11. 22 CFR 506.7 - Exceptions.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 22 Foreign Relations 2 2012-04-01 2009-04-01 true Exceptions. 506.7 Section 506.7 Foreign Relations BROADCASTING BOARD OF GOVERNORS PART-TIME CAREER EMPLOYMENT PROGRAM § 506.7 Exceptions. The Director of the Board and the Associate Director for Management may except positions from inclusion in this...

  12. 22 CFR 506.7 - Exceptions.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 22 Foreign Relations 2 2013-04-01 2009-04-01 true Exceptions. 506.7 Section 506.7 Foreign Relations BROADCASTING BOARD OF GOVERNORS PART-TIME CAREER EMPLOYMENT PROGRAM § 506.7 Exceptions. The Director of the Board and the Associate Director for Management may except positions from inclusion in this...

  13. 22 CFR 506.7 - Exceptions.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 22 Foreign Relations 2 2014-04-01 2014-04-01 false Exceptions. 506.7 Section 506.7 Foreign Relations BROADCASTING BOARD OF GOVERNORS PART-TIME CAREER EMPLOYMENT PROGRAM § 506.7 Exceptions. The Director of the Board and the Associate Director for Management may except positions from inclusion in this...

  14. 22 CFR 126.3 - Exceptions.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 22 Foreign Relations 1 2011-04-01 2011-04-01 false Exceptions. 126.3 Section 126.3 Foreign Relations DEPARTMENT OF STATE INTERNATIONAL TRAFFIC IN ARMS REGULATIONS GENERAL POLICIES AND PROVISIONS § 126.3 Exceptions. In a case of exceptional or undue hardship, or when it is otherwise in the...

  15. 22 CFR 126.3 - Exceptions.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 22 Foreign Relations 1 2012-04-01 2012-04-01 false Exceptions. 126.3 Section 126.3 Foreign Relations DEPARTMENT OF STATE INTERNATIONAL TRAFFIC IN ARMS REGULATIONS GENERAL POLICIES AND PROVISIONS § 126.3 Exceptions. In a case of exceptional or undue hardship, or when it is otherwise in the...

  16. 22 CFR 126.3 - Exceptions.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Exceptions. 126.3 Section 126.3 Foreign Relations DEPARTMENT OF STATE INTERNATIONAL TRAFFIC IN ARMS REGULATIONS GENERAL POLICIES AND PROVISIONS § 126.3 Exceptions. In a case of exceptional or undue hardship, or when it is otherwise in the...

  17. 22 CFR 126.3 - Exceptions.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 22 Foreign Relations 1 2013-04-01 2013-04-01 false Exceptions. 126.3 Section 126.3 Foreign Relations DEPARTMENT OF STATE INTERNATIONAL TRAFFIC IN ARMS REGULATIONS GENERAL POLICIES AND PROVISIONS § 126.3 Exceptions. In a case of exceptional or undue hardship, or when it is otherwise in the...

  18. Technology Applications for the Exceptional Learner.

    ERIC Educational Resources Information Center

    Burke, Janet

    This paper is a series of lesson plans designed to assist teachers with the instruction of the exceptional learner. The focus is on identifying what the exceptional learner needs, and provides specific lesson plans that met those needs. Exceptional learners experience difficulty with spelling, organization, and metacognition. Detailed directions…

  19. 15 CFR 30.62 - Emergency exceptions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 15 Commerce and Foreign Trade 1 2012-01-01 2012-01-01 false Emergency exceptions. 30.62 Section 30.62 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade BUREAU OF THE CENSUS... exceptions. The Census Bureau and CBP may jointly authorize the postponement of or exception to...

  20. 15 CFR 30.62 - Emergency exceptions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 15 Commerce and Foreign Trade 1 2010-01-01 2010-01-01 false Emergency exceptions. 30.62 Section 30.62 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade BUREAU OF THE CENSUS... exceptions. The Census Bureau and CBP may jointly authorize the postponement of or exception to...

  1. 15 CFR 30.62 - Emergency exceptions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 15 Commerce and Foreign Trade 1 2011-01-01 2011-01-01 false Emergency exceptions. 30.62 Section 30.62 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade BUREAU OF THE CENSUS... exceptions. The Census Bureau and CBP may jointly authorize the postponement of or exception to...

  2. 15 CFR 30.62 - Emergency exceptions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 15 Commerce and Foreign Trade 1 2014-01-01 2014-01-01 false Emergency exceptions. 30.62 Section 30.62 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade BUREAU OF THE CENSUS... exceptions. The Census Bureau and CBP may jointly authorize the postponement of or exception to...

  3. 15 CFR 30.62 - Emergency exceptions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 15 Commerce and Foreign Trade 1 2013-01-01 2013-01-01 false Emergency exceptions. 30.62 Section 30.62 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade BUREAU OF THE CENSUS... exceptions. The Census Bureau and CBP may jointly authorize the postponement of or exception to...

  4. 48 CFR 8.706 - Purchase exceptions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Purchase exceptions. 8.706... Blind or Severely Disabled 8.706 Purchase exceptions. (a) Ordering offices may acquire supplies or... in a purchase exception granted by the designated central nonprofit agency. (b) The central nonprofit...

  5. 7 CFR 773.23 - Exception.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 7 2014-01-01 2014-01-01 false Exception. 773.23 Section 773.23 Agriculture Regulations of the Department of Agriculture (Continued) FARM SERVICE AGENCY, DEPARTMENT OF AGRICULTURE SPECIAL PROGRAMS SPECIAL APPLE LOAN PROGRAM § 773.23 Exception. The Agency may grant an exception to the...

  6. 7 CFR 773.23 - Exception.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 7 2012-01-01 2012-01-01 false Exception. 773.23 Section 773.23 Agriculture Regulations of the Department of Agriculture (Continued) FARM SERVICE AGENCY, DEPARTMENT OF AGRICULTURE SPECIAL PROGRAMS SPECIAL APPLE LOAN PROGRAM § 773.23 Exception. The Agency may grant an exception to the...

  7. 7 CFR 773.23 - Exception.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 7 2010-01-01 2010-01-01 false Exception. 773.23 Section 773.23 Agriculture Regulations of the Department of Agriculture (Continued) FARM SERVICE AGENCY, DEPARTMENT OF AGRICULTURE SPECIAL PROGRAMS SPECIAL APPLE LOAN PROGRAM § 773.23 Exception. The Agency may grant an exception to the...

  8. 7 CFR 773.23 - Exception.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 7 2011-01-01 2011-01-01 false Exception. 773.23 Section 773.23 Agriculture Regulations of the Department of Agriculture (Continued) FARM SERVICE AGENCY, DEPARTMENT OF AGRICULTURE SPECIAL PROGRAMS SPECIAL APPLE LOAN PROGRAM § 773.23 Exception. The Agency may grant an exception to the...

  9. 7 CFR 773.23 - Exception.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 7 2013-01-01 2013-01-01 false Exception. 773.23 Section 773.23 Agriculture Regulations of the Department of Agriculture (Continued) FARM SERVICE AGENCY, DEPARTMENT OF AGRICULTURE SPECIAL PROGRAMS SPECIAL APPLE LOAN PROGRAM § 773.23 Exception. The Agency may grant an exception to the...

  10. Identifying Twice Exceptional Children: A Toolkit for Success

    ERIC Educational Resources Information Center

    Rizza, Mary G.; Morrison, William F.

    2007-01-01

    Students identified as gifted who also display one or more areas of disability remain under-identified both in special and gifted education programs. All too often school personnel do not have the resources necessary to make decisions about this unique group of students commonly called the twice-exceptional. The purpose of this article is to…

  11. Three most common nonsynonymous UGT1A6*2 polymorphisms (Thr181Ala, Arg184Ser and Ser7Ala) and therapeutic response to deferiprone in β-thalassemia major patients.

    PubMed

    Dadheech, Sneha; Rao, A Venkateswara; Shaheen, Uzma; Hussien, Mohammed Dyia; Jain, Suman; Jyothy, A; Munshi, Anjana

    2013-12-01

    Deferiprone is used as a chelation agent in chronic iron overload in β-thalassemia patients. Patients on deferiprone therapy show variable response to this drug in terms of reduction in iron overload as well as adverse drug reactions (ADRs). The pharmacogenetic studies on deferiprone have not carried out in patients with blood disorders in India. Therefore, the present study was carried out to evaluate the three most common nonsynonymous UGT1A6 polymorphisms Thr181Ala (541 A/G), Arg184Ser (552 A/C) and Ser7Ala (19 T/G) and therapeutic response to deferiprone in β-thalassemia major patients. Two hundred and eighty six (286) β-thalassemia major patients were involved in the study. Serum ferritin levels were estimated periodically to assess the status of the iron overload and the patients were grouped into responders and non-responders depending on the ferritin levels. The UGT1A6 2 polymorphisms were detected by PCR-RFLP methods. The association between the genotypes and outcome as well as ADRs was evaluated by Open EPI software. A significant difference was observed in the genotypic distribution of UGT1A6 2 Thr181Ala polymorphism in responders and non-responders. However, there was no difference in the genotypic distribution between patients with and without ADRs. As far as the UGT1A6 2 Arg184Ser polymorphism is concerned, no significant difference was observed between responders and non-responders. Further, evaluating the association of UGT1A6 2 Ser7Ala polymorphism with drug response, there was no significant difference in the genotypic distribution between responders and non-responders. However, there was a significant difference between responders with and without ADRs and non-responders with and without ADRs. In addition to this haplotype analysis was also carried out. However, we did not find any specific haplotype to be significantly associated with the deferiprone response in β-thalassemia major patients. © 2013 Elsevier B.V. All rights reserved.

  12. The Exceptional Adolescent: A Bibliography for Psychology and Education.

    ERIC Educational Resources Information Center

    McMurray, J. G.

    Presented is a bibliography of Journal articles printed in English and published since 1970 on the psychology and education of the exceptional adolescent. Entries are divided into six major sections (subdivisions are in parentheses): general (background reading, technology, management, mental health, curriculum, counseling, etc.), intellectual…

  13. The Exceptional Adolescent: A Bibliography for Psychology and Education.

    ERIC Educational Resources Information Center

    McMurray, J. G.

    Presented is a bibliography of Journal articles printed in English and published since 1970 on the psychology and education of the exceptional adolescent. Entries are divided into six major sections (subdivisions are in parentheses): general (background reading, technology, management, mental health, curriculum, counseling, etc.), intellectual…

  14. The Exceptional Child and the Law: Annotated Bibliography.

    ERIC Educational Resources Information Center

    Smith, Frank Tupper, Jr.; Smith, Jill

    Intended to help those concerned with the rights and priviledges of the handicapped, the bibliography cites approximately 150 print and non-print sources of information on legislation and advocacy for the exceptional individual. Four major sections cover the following: (1) legal factors and problems within the family setting; (2) legal factors and…

  15. Common cold

    MedlinePlus

    ... this page: //medlineplus.gov/ency/article/000678.htm Common cold To use the sharing features on this page, please enable JavaScript. The common cold most often causes a runny nose, nasal congestion, ...

  16. A Year of Exceptional Achievements FY 2008

    SciTech Connect

    devore, L; Chrzanowski, P

    2008-11-06

    2008 highlights: (1) Stockpile Stewardship and Complex Transformation - LLNL achieved scientific breakthroughs that explain some of the key 'unknowns' in nuclear weapons performance and are critical to developing the predictive science needed to ensure the safety, reliability, and security of the U.S. nuclear deterrent without nuclear testing. In addition, the National Ignition Facility (NIF) passed 99 percent completion, an LLNL supercomputer simulation won the 2007 Gordon Bell Prize, and a significant fraction of our inventory of special nuclear material was shipped to other sites in support of complex transformation. (2) National and Global Security - Laboratory researchers delivered insights, technologies, and operational capabilities that are helping to ensure national security and global stability. Of particular note, they developed advanced detection instruments that provide increased speed, accuracy, specificity, and resolution for identifying and characterizing biological, chemical, nuclear, and high-explosive threats. (3) Exceptional Science and Technology - The Laboratory continued its tradition of scientific excellence and technical innovation. LLNL scientists made significant contributions to Nobel Prize-winning work on climate change. LLNL also received three R&D 100 awards and six Nanotech 50 awards, and dozens of Laboratory scientists and engineers were recognized with professional awards. These honors provide valuable confirmation that peers and outside experts recognize the quality of our staff and our work. (4) Enhanced Business and Operations - A major thrust under LLNS is to make the Laboratory more efficient and cost competitive. We achieved roughly $75 million in cost savings for support activities through organizational changes, consolidation of services, improved governance structures and work processes, technology upgrades, and systems shared with Los Alamos National Laboratory. We realized nonlabor cost savings of $23 million. Severe

  17. 7 CFR 1924.122 - Exception authority.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ...-COOPERATIVE SERVICE, RURAL UTILITIES SERVICE, AND FARM SERVICE AGENCY, DEPARTMENT OF AGRICULTURE PROGRAM REGULATIONS CONSTRUCTION AND REPAIR Planning and Performing Site Development Work § 1924.122 Exception...

  18. 48 CFR 1503.602 - Exceptions.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... BUSINESS PRACTICES AND PERSONAL CONFLICTS OF INTEREST Contracts with Government Employees or Organizations... shall consult with the Designated Agency Ethics Official before authorizing any exceptions. ...

  19. 48 CFR 1503.602 - Exceptions.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... BUSINESS PRACTICES AND PERSONAL CONFLICTS OF INTEREST Contracts with Government Employees or Organizations... shall consult with the Designated Agency Ethics Official before authorizing any exceptions. ...

  20. Clays, common

    USGS Publications Warehouse

    Virta, R.L.

    1998-01-01

    Part of a special section on the state of industrial minerals in 1997. The state of the common clay industry worldwide for 1997 is discussed. Sales of common clay in the U.S. increased from 26.2 Mt in 1996 to an estimated 26.5 Mt in 1997. The amount of common clay and shale used to produce structural clay products in 1997 was estimated at 13.8 Mt.

  1. Commons Sense.

    ERIC Educational Resources Information Center

    Payne, William E.; Tyler, Charles R.

    1999-01-01

    Explains how a commons area can serve both the school and community by becoming a cost-effective, space-saving asset to the school building. Examines the commons area as a place for interaction; discusses subdividing it into smaller functional units, locating it, and related lighting and heating issues. (GR)

  2. Student Commons

    ERIC Educational Resources Information Center

    Gordon, Douglas

    2010-01-01

    Student commons are no longer simply congregation spaces for students with time on their hands. They are integral to providing a welcoming environment and effective learning space for students. Many student commons have been transformed into spaces for socialization, an environment for alternative teaching methods, a forum for large group meetings…

  3. 7 CFR 501.15 - Exceptions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Regulations of the Department of Agriculture (Continued) AGRICULTURAL RESEARCH SERVICE, DEPARTMENT OF AGRICULTURE CONDUCT ON U.S. MEAT ANIMAL RESEARCH CENTER, CLAY CENTER, NEBRASKA § 501.15 Exceptions. The Administrator, Agricultural Research Service, may in individual cases make prior, written exceptions to the...

  4. 7 CFR 501.15 - Exceptions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Regulations of the Department of Agriculture (Continued) AGRICULTURAL RESEARCH SERVICE, DEPARTMENT OF AGRICULTURE CONDUCT ON U.S. MEAT ANIMAL RESEARCH CENTER, CLAY CENTER, NEBRASKA § 501.15 Exceptions. The Administrator, Agricultural Research Service, may in individual cases make prior, written exceptions to the...

  5. 7 CFR 501.15 - Exceptions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Regulations of the Department of Agriculture (Continued) AGRICULTURAL RESEARCH SERVICE, DEPARTMENT OF AGRICULTURE CONDUCT ON U.S. MEAT ANIMAL RESEARCH CENTER, CLAY CENTER, NEBRASKA § 501.15 Exceptions. The Administrator, Agricultural Research Service, may in individual cases make prior, written exceptions to the...

  6. 7 CFR 501.15 - Exceptions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Regulations of the Department of Agriculture (Continued) AGRICULTURAL RESEARCH SERVICE, DEPARTMENT OF AGRICULTURE CONDUCT ON U.S. MEAT ANIMAL RESEARCH CENTER, CLAY CENTER, NEBRASKA § 501.15 Exceptions. The Administrator, Agricultural Research Service, may in individual cases make prior, written exceptions to the...

  7. 7 CFR 501.15 - Exceptions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Regulations of the Department of Agriculture (Continued) AGRICULTURAL RESEARCH SERVICE, DEPARTMENT OF AGRICULTURE CONDUCT ON U.S. MEAT ANIMAL RESEARCH CENTER, CLAY CENTER, NEBRASKA § 501.15 Exceptions. The Administrator, Agricultural Research Service, may in individual cases make prior, written exceptions to the...

  8. Parent Counseling: Exceptional Child Bibliography Series.

    ERIC Educational Resources Information Center

    Council for Exceptional Children, Reston, VA. Information Center on Exceptional Children.

    One in a series of over 50 similar listings related to exceptional children, both handicapped and gifted, the annotated bibliography contains 76 references dealing with the counseling of parents of exceptional children. Ranging across all handicapping conditions, physical and mental, and giftedness, the references treat such aspects of parent…

  9. 24 CFR 300.15 - Exceptions.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 24 Housing and Urban Development 2 2011-04-01 2011-04-01 false Exceptions. 300.15 Section 300.15 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued) GOVERNMENT NATIONAL MORTGAGE ASSOCIATION, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT GENERAL § 300.15 Exceptions....

  10. 24 CFR 300.15 - Exceptions.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 24 Housing and Urban Development 2 2012-04-01 2012-04-01 false Exceptions. 300.15 Section 300.15 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued) GOVERNMENT NATIONAL MORTGAGE ASSOCIATION, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT GENERAL § 300.15 Exceptions....

  11. 48 CFR 8.605 - Exceptions.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Exceptions. 8.605 Section 8.605 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION ACQUISITION PLANNING REQUIRED SOURCES OF SUPPLIES AND SERVICES Acquisition From Federal Prison Industries, Inc. 8.605 Exceptions...

  12. 48 CFR 8.605 - Exceptions.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 1 2013-10-01 2013-10-01 false Exceptions. 8.605 Section 8.605 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION ACQUISITION PLANNING REQUIRED SOURCES OF SUPPLIES AND SERVICES Acquisition From Federal Prison Industries, Inc. 8.605 Exceptions...

  13. 48 CFR 8.706 - Purchase exceptions.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 1 2013-10-01 2013-10-01 false Purchase exceptions. 8.706 Section 8.706 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION ACQUISITION PLANNING... Blind or Severely Disabled 8.706 Purchase exceptions. (a) Ordering offices may acquire supplies or...

  14. 48 CFR 8.706 - Purchase exceptions.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 1 2014-10-01 2014-10-01 false Purchase exceptions. 8.706 Section 8.706 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION ACQUISITION PLANNING... Blind or Severely Disabled 8.706 Purchase exceptions. (a) Ordering offices may acquire supplies or...

  15. 48 CFR 8.605 - Exceptions.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 1 2014-10-01 2014-10-01 false Exceptions. 8.605 Section 8.605 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION ACQUISITION PLANNING REQUIRED SOURCES OF SUPPLIES AND SERVICES Acquisition From Federal Prison Industries, Inc. 8.605 Exceptions...

  16. 39 CFR 310.3 - Exceptions.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... fall under this exception. (d) Special messenger. (1) The use of a special messenger employed for the.... The permission granted under this exception is restricted to use of messenger service on an infrequent, irregular basis by the sender or addressee of the message. (2) A special messenger is a person who, at...

  17. 39 CFR 310.3 - Exceptions.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... fall under this exception. (d) Special messenger. (1) The use of a special messenger employed for the.... The permission granted under this exception is restricted to use of messenger service on an infrequent, irregular basis by the sender or addressee of the message. (2) A special messenger is a person who, at...

  18. 39 CFR 310.3 - Exceptions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... fall under this exception. (d) Special messenger. (1) The use of a special messenger employed for the.... The permission granted under this exception is restricted to use of messenger service on an infrequent, irregular basis by the sender or addressee of the message. (2) A special messenger is a person who, at...

  19. 39 CFR 310.3 - Exceptions.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... fall under this exception. (d) Special messenger. (1) The use of a special messenger employed for the.... The permission granted under this exception is restricted to use of messenger service on an infrequent, irregular basis by the sender or addressee of the message. (2) A special messenger is a person who, at...

  20. 39 CFR 310.3 - Exceptions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... fall under this exception. (d) Special messenger. (1) The use of a special messenger employed for the.... The permission granted under this exception is restricted to use of messenger service on an infrequent, irregular basis by the sender or addressee of the message. (2) A special messenger is a person who, at...

  1. 31 CFR 82.2 - Exceptions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 1 2010-07-01 2010-07-01 false Exceptions. 82.2 Section 82.2 Money and Finance: Treasury Regulations Relating to Money and Finance 5-CENT AND ONE-CENT COIN REGULATIONS § 82.2 Exceptions. (a) The prohibition contained in § 82.1 against the exportation of 5-cent coins and...

  2. 47 CFR 2.807 - Statutory exceptions.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 47 Telecommunication 1 2013-10-01 2013-10-01 false Statutory exceptions. 2.807 Section 2.807 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL FREQUENCY ALLOCATIONS AND RADIO TREATY MATTERS; GENERAL RULES AND REGULATIONS Marketing of Radio-frequency Devices § 2.807 Statutory exceptions. As provided...

  3. 47 CFR 2.807 - Statutory exceptions.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 1 2014-10-01 2014-10-01 false Statutory exceptions. 2.807 Section 2.807 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL FREQUENCY ALLOCATIONS AND RADIO TREATY MATTERS; GENERAL RULES AND REGULATIONS Marketing of Radio-frequency Devices § 2.807 Statutory exceptions. As provided...

  4. 47 CFR 2.807 - Statutory exceptions.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 1 2011-10-01 2011-10-01 false Statutory exceptions. 2.807 Section 2.807 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL FREQUENCY ALLOCATIONS AND RADIO TREATY MATTERS; GENERAL RULES AND REGULATIONS Marketing of Radio-frequency Devices § 2.807 Statutory exceptions. As provided...

  5. 47 CFR 2.807 - Statutory exceptions.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 47 Telecommunication 1 2012-10-01 2012-10-01 false Statutory exceptions. 2.807 Section 2.807 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL FREQUENCY ALLOCATIONS AND RADIO TREATY MATTERS; GENERAL RULES AND REGULATIONS Marketing of Radio-frequency Devices § 2.807 Statutory exceptions. As provided...

  6. 47 CFR 2.807 - Statutory exceptions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 1 2010-10-01 2010-10-01 false Statutory exceptions. 2.807 Section 2.807 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL FREQUENCY ALLOCATIONS AND RADIO TREATY MATTERS; GENERAL RULES AND REGULATIONS Marketing of Radio-frequency Devices § 2.807 Statutory exceptions. As provided...

  7. 14 CFR 34.9 - Exceptions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... EXHAUST EMISSION REQUIREMENTS FOR TURBINE ENGINE POWERED AIRPLANES General Provisions § 34.9 Exceptions... exception allows production of an engine for installation on an in-service aircraft. A spare engine may not... certificated to meet all applicable requirements. (3) A spare engine may be used only when the emissions of...

  8. 14 CFR 34.9 - Exceptions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... EXHAUST EMISSION REQUIREMENTS FOR TURBINE ENGINE POWERED AIRPLANES General Provisions § 34.9 Exceptions... exception allows production of an engine for installation on an in-service aircraft. A spare engine may not... certificated to meet all applicable requirements. (3) A spare engine may be used only when the emissions of...

  9. 7 CFR 503.15 - Exceptions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 6 2012-01-01 2012-01-01 false Exceptions. 503.15 Section 503.15 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL RESEARCH SERVICE, DEPARTMENT OF AGRICULTURE CONDUCT ON PLUM ISLAND ANIMAL DISEASE CENTER § 503.15 Exceptions. The Director, PIADC, may, in...

  10. 7 CFR 503.15 - Exceptions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 6 2011-01-01 2011-01-01 false Exceptions. 503.15 Section 503.15 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL RESEARCH SERVICE, DEPARTMENT OF AGRICULTURE CONDUCT ON PLUM ISLAND ANIMAL DISEASE CENTER § 503.15 Exceptions. The Director, PIADC, may, in...

  11. 7 CFR 503.15 - Exceptions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 6 2010-01-01 2010-01-01 false Exceptions. 503.15 Section 503.15 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL RESEARCH SERVICE, DEPARTMENT OF AGRICULTURE CONDUCT ON PLUM ISLAND ANIMAL DISEASE CENTER § 503.15 Exceptions. The Director, PIADC, may, in...

  12. 7 CFR 503.15 - Exceptions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 6 2013-01-01 2013-01-01 false Exceptions. 503.15 Section 503.15 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL RESEARCH SERVICE, DEPARTMENT OF AGRICULTURE CONDUCT ON PLUM ISLAND ANIMAL DISEASE CENTER § 503.15 Exceptions. The Director, PIADC, may, in...

  13. 7 CFR 503.15 - Exceptions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 6 2014-01-01 2014-01-01 false Exceptions. 503.15 Section 503.15 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL RESEARCH SERVICE, DEPARTMENT OF AGRICULTURE CONDUCT ON PLUM ISLAND ANIMAL DISEASE CENTER § 503.15 Exceptions. The Director, PIADC, may, in...

  14. 24 CFR 91.20 - Exceptions.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Exceptions. 91.20 Section 91.20 Housing and Urban Development Office of the Secretary, Department of Housing and Urban Development CONSOLIDATED SUBMISSIONS FOR COMMUNITY PLANNING AND DEVELOPMENT PROGRAMS General § 91.20 Exceptions. The...

  15. 38 CFR 1.897 - Exceptions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2011-07-01 2011-07-01 false Exceptions. 1.897 Section 1.897 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS GENERAL PROVISIONS Part-Time Career Employment Program § 1.897 Exceptions. The Secretary of Veterans Affairs, or designees,...

  16. 38 CFR 1.897 - Exceptions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2010-07-01 2010-07-01 false Exceptions. 1.897 Section 1.897 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS GENERAL PROVISIONS Part-Time Career Employment Program § 1.897 Exceptions. The Secretary of Veterans Affairs, or designees,...

  17. 48 CFR 425.103 - Exceptions.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 4 2014-10-01 2014-10-01 false Exceptions. 425.103 Section 425.103 Federal Acquisition Regulations System DEPARTMENT OF AGRICULTURE SOCIOECONOMIC PROGRAMS FOREIGN ACQUISITION Buy American Act-Supplies 425.103 Exceptions. (a) The Senior Procurement...

  18. 48 CFR 425.103 - Exceptions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Exceptions. 425.103 Section 425.103 Federal Acquisition Regulations System DEPARTMENT OF AGRICULTURE SOCIOECONOMIC PROGRAMS FOREIGN ACQUISITION Buy American Act-Supplies 425.103 Exceptions. (a) The Senior Procurement...

  19. 48 CFR 425.103 - Exceptions.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 4 2012-10-01 2012-10-01 false Exceptions. 425.103 Section 425.103 Federal Acquisition Regulations System DEPARTMENT OF AGRICULTURE SOCIOECONOMIC PROGRAMS FOREIGN ACQUISITION Buy American Act-Supplies 425.103 Exceptions. (a) The Senior Procurement...

  20. 48 CFR 425.103 - Exceptions.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 4 2013-10-01 2013-10-01 false Exceptions. 425.103 Section 425.103 Federal Acquisition Regulations System DEPARTMENT OF AGRICULTURE SOCIOECONOMIC PROGRAMS FOREIGN ACQUISITION Buy American Act-Supplies 425.103 Exceptions. (a) The Senior Procurement...

  1. 48 CFR 425.103 - Exceptions.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 4 2011-10-01 2011-10-01 false Exceptions. 425.103 Section 425.103 Federal Acquisition Regulations System DEPARTMENT OF AGRICULTURE SOCIOECONOMIC PROGRAMS FOREIGN ACQUISITION Buy American Act-Supplies 425.103 Exceptions. (a) The Senior Procurement...

  2. 42 CFR 1001.952 - Exceptions.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 5 2011-10-01 2011-10-01 false Exceptions. 1001.952 Section 1001.952 Public Health OFFICE OF INSPECTOR GENERAL-HEALTH CARE, DEPARTMENT OF HEALTH AND HUMAN SERVICES OIG AUTHORITIES PROGRAM INTEGRITY-MEDICARE AND STATE HEALTH CARE PROGRAMS Permissive Exclusions § 1001.952 Exceptions. The following payment practices shall not be...

  3. 45 CFR 1176.8 - Exceptions.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 45 Public Welfare 3 2012-10-01 2012-10-01 false Exceptions. 1176.8 Section 1176.8 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL FOUNDATION ON THE ARTS AND THE HUMANITIES NATIONAL ENDOWMENT FOR THE HUMANITIES PART-TIME CAREER EMPLOYMENT § 1176.8 Exceptions. (a) The Personnel Officer may...

  4. 45 CFR 1176.8 - Exceptions.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 45 Public Welfare 3 2013-10-01 2013-10-01 false Exceptions. 1176.8 Section 1176.8 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL FOUNDATION ON THE ARTS AND THE HUMANITIES NATIONAL ENDOWMENT FOR THE HUMANITIES PART-TIME CAREER EMPLOYMENT § 1176.8 Exceptions. (a) The Personnel Officer may...

  5. 45 CFR 1176.8 - Exceptions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 3 2010-10-01 2010-10-01 false Exceptions. 1176.8 Section 1176.8 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL FOUNDATION ON THE ARTS AND THE HUMANITIES NATIONAL ENDOWMENT FOR THE HUMANITIES PART-TIME CAREER EMPLOYMENT § 1176.8 Exceptions. (a) The Personnel Officer may...

  6. 45 CFR 1176.8 - Exceptions.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 45 Public Welfare 3 2014-10-01 2014-10-01 false Exceptions. 1176.8 Section 1176.8 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL FOUNDATION ON THE ARTS AND THE HUMANITIES NATIONAL ENDOWMENT FOR THE HUMANITIES PART-TIME CAREER EMPLOYMENT § 1176.8 Exceptions. (a) The Personnel Officer may...

  7. 45 CFR 1176.8 - Exceptions.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 45 Public Welfare 3 2011-10-01 2011-10-01 false Exceptions. 1176.8 Section 1176.8 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL FOUNDATION ON THE ARTS AND THE HUMANITIES NATIONAL ENDOWMENT FOR THE HUMANITIES PART-TIME CAREER EMPLOYMENT § 1176.8 Exceptions. (a) The Personnel Officer may...

  8. 48 CFR 925.202 - Exceptions.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 5 2014-10-01 2014-10-01 false Exceptions. 925.202 Section 925.202 Federal Acquisition Regulations System DEPARTMENT OF ENERGY SOCIOECONOMIC PROGRAMS FOREIGN ACQUISITION Buy American Act-Construction Materials 925.202 Exceptions. (a)(2) Contracting officers may make...

  9. 48 CFR 625.103 - Exceptions.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 4 2011-10-01 2011-10-01 false Exceptions. 625.103 Section 625.103 Federal Acquisition Regulations System DEPARTMENT OF STATE SOCIOECONOMIC PROGRAMS FOREIGN ACQUISITION Buy American Act-Supplies 625.103 Exceptions. (a) The authority to make the determination...

  10. 48 CFR 825.103 - Exceptions.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 5 2014-10-01 2014-10-01 false Exceptions. 825.103 Section 825.103 Federal Acquisition Regulations System DEPARTMENT OF VETERANS AFFAIRS SOCIOECONOMIC PROGRAMS FOREIGN ACQUISITION Buy American Act-Supplies 825.103 Exceptions. (a) Public interest. When a...

  11. 48 CFR 625.202 - Exceptions.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 4 2011-10-01 2011-10-01 false Exceptions. 625.202 Section 625.202 Federal Acquisition Regulations System DEPARTMENT OF STATE SOCIOECONOMIC PROGRAMS FOREIGN ACQUISITION Buy American Act-Construction Materials 625.202 Exceptions. (a)(1) The authority to make the...

  12. 48 CFR 925.103 - Exceptions.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 5 2014-10-01 2014-10-01 false Exceptions. 925.103 Section 925.103 Federal Acquisition Regulations System DEPARTMENT OF ENERGY SOCIOECONOMIC PROGRAMS FOREIGN ACQUISITION Buy American Act-Supplies 925.103 Exceptions. (a) Contracting officers may make the determination...

  13. 48 CFR 225.7017-3 - Exceptions.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... to utilize domestic photovoltaic devices in covered contracts, with the following exceptions: (a) Qualifying country. Qualifying country photovoltaic devices may be utilized in any covered contract, because... photovoltaic devices valued at less than $204,000, the exception for unreasonable cost may apply (see FAR...

  14. 48 CFR 225.7017-3 - Exceptions.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... to utilize domestic photovoltaic devices in covered contracts, with the following exceptions: (a) Qualifying country. Qualifying country photovoltaic devices may be utilized in any covered contract, because... photovoltaic devices valued at less than $202,000, the exception for unreasonable cost may apply (see FAR...

  15. 48 CFR 225.7017-3 - Exceptions.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... to utilize domestic photovoltaic devices in covered contracts, with the following exceptions: (a) Qualifying country. Qualifying country photovoltaic devices may be utilized in any covered contract, because... photovoltaic devices valued at less than $202,000, the exception for unreasonable cost may apply (see FAR...

  16. 45 CFR 148.220 - Excepted benefits.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... and automobile liability insurance. (4) Coverage issued as a supplement to liability insurance. (5) Workers' compensation or similar insurance. (6) Automobile medical payment insurance. (7) Credit-only... FOR THE INDIVIDUAL HEALTH INSURANCE MARKET Preemption; Excepted Benefits § 148.220 Excepted...

  17. 40 CFR 1517.4 - Exceptions.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 34 2013-07-01 2013-07-01 false Exceptions. 1517.4 Section 1517.4 Protection of Environment COUNCIL ON ENVIRONMENTAL QUALITY PUBLIC MEETING PROCEDURES OF THE COUNCIL ON ENVIRONMENTAL QUALITY § 1517.4 Exceptions. (a) A meeting or portion thereof may be closed to public observation...

  18. Physical Facilities: Exceptional Child Bibliography Series.

    ERIC Educational Resources Information Center

    Council for Exceptional Children, Reston, VA. Information Center on Exceptional Children.

    The annotated bibliography, one in a series of over 50 similar listings related to handicapped and gifted children, contains 91 references selected from Exceptional Child Education Abstracts dealing with physical facilities, educational or institutional, for exceptional children. The entries, which include texts, journal articles, research…

  19. 39 CFR 3055.3 - Reporting exceptions.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 39 Postal Service 1 2014-07-01 2014-07-01 false Reporting exceptions. 3055.3 Section 3055.3 Postal Service POSTAL REGULATORY COMMISSION PERSONNEL SERVICE PERFORMANCE AND CUSTOMER SATISFACTION REPORTING Annual Reporting of Service Performance Achievements § 3055.3 Reporting exceptions. (a) The...

  20. 39 CFR 3055.3 - Reporting exceptions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 39 Postal Service 1 2011-07-01 2011-07-01 false Reporting exceptions. 3055.3 Section 3055.3 Postal Service POSTAL REGULATORY COMMISSION PERSONNEL SERVICE PERFORMANCE AND CUSTOMER SATISFACTION REPORTING Annual Reporting of Service Performance Achievements § 3055.3 Reporting exceptions. (a) The...

  1. 39 CFR 3055.3 - Reporting exceptions.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 39 Postal Service 1 2013-07-01 2013-07-01 false Reporting exceptions. 3055.3 Section 3055.3 Postal Service POSTAL REGULATORY COMMISSION PERSONNEL SERVICE PERFORMANCE AND CUSTOMER SATISFACTION REPORTING Annual Reporting of Service Performance Achievements § 3055.3 Reporting exceptions. (a) The...

  2. 39 CFR 3055.3 - Reporting exceptions.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 39 Postal Service 1 2012-07-01 2012-07-01 false Reporting exceptions. 3055.3 Section 3055.3 Postal Service POSTAL REGULATORY COMMISSION PERSONNEL SERVICE PERFORMANCE AND CUSTOMER SATISFACTION REPORTING Annual Reporting of Service Performance Achievements § 3055.3 Reporting exceptions. (a) The...

  3. Twice-Exceptional Children: Paradoxes and Parenting

    ERIC Educational Resources Information Center

    Giovacco-Johnson, Tricia

    2007-01-01

    For seven years, the author has been the parent of a wonderfully uniquely gifted little boy, who has taught her all about "exceptional" parenting. Her child, Adrian, is a "twice-exceptional" child who is both intellectually gifted and has special needs that negatively impact his development and learning. Initially, the contradictions of parenting…

  4. 40 CFR 262.55 - Exception reports.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 26 2011-07-01 2011-07-01 false Exception reports. 262.55 Section 262.55 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS APPLICABLE TO GENERATORS OF HAZARDOUS WASTE Exports of Hazardous Waste § 262.55 Exception reports...

  5. 40 CFR 262.55 - Exception reports.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 26 2014-07-01 2014-07-01 false Exception reports. 262.55 Section 262.55 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS APPLICABLE TO GENERATORS OF HAZARDOUS WASTE Exports of Hazardous Waste § 262.55 Exception reports...

  6. 40 CFR 262.55 - Exception reports.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 27 2013-07-01 2013-07-01 false Exception reports. 262.55 Section 262.55 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS APPLICABLE TO GENERATORS OF HAZARDOUS WASTE Exports of Hazardous Waste § 262.55 Exception reports...

  7. 40 CFR 262.55 - Exception reports.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 27 2012-07-01 2012-07-01 false Exception reports. 262.55 Section 262.55 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS APPLICABLE TO GENERATORS OF HAZARDOUS WASTE Exports of Hazardous Waste § 262.55 Exception reports...

  8. 40 CFR 262.55 - Exception reports.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 25 2010-07-01 2010-07-01 false Exception reports. 262.55 Section 262.55 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS APPLICABLE TO GENERATORS OF HAZARDOUS WASTE Exports of Hazardous Waste § 262.55 Exception reports...

  9. Twice Exceptionality from a Practitioner's Perspective

    ERIC Educational Resources Information Center

    Omdal, Stuart

    2015-01-01

    The new definition of twice exceptionality by the National Twice-Exceptional Community of Practice (2e CoP) is a tool that will facilitate communication and collaboration for practitioners in the regular classroom, gifted education specialists, administrators, and professors. In this article, the author shares his experiences in several of these…

  10. 48 CFR 1.501-3 - Exceptions.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 1 2013-10-01 2013-10-01 false Exceptions. 1.501-3 Section 1.501-3 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION GENERAL FEDERAL ACQUISITION REGULATIONS SYSTEM Agency and Public Participation 1.501-3 Exceptions. (a) Comments need not be...

  11. 12 CFR 622.13 - Exceptions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... exception shall be supported by a concise argument and by citation of such statutes, decisions and other... Banking FARM CREDIT ADMINISTRATION FARM CREDIT SYSTEM RULES OF PRACTICE AND PROCEDURE Rules Applicable to Formal Hearings § 622.13 Exceptions. (a) Filing. Within 15 days after service of the recommended decision...

  12. 45 CFR 1226.9 - Exceptions.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... the State Director on a quarterly basis of all activity occurring pursuant to this exception. (2) The... ON ELECTORAL AND LOBBYING ACTIVITIES Volunteer Activities § 1226.9 Exceptions. (a) A volunteer may... addressed. (3) The volunteer or the program sponsor provides a copy of such request to the State...

  13. 45 CFR 1226.9 - Exceptions.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... the State Director on a quarterly basis of all activity occurring pursuant to this exception. (2) The... ON ELECTORAL AND LOBBYING ACTIVITIES Volunteer Activities § 1226.9 Exceptions. (a) A volunteer may... addressed. (3) The volunteer or the program sponsor provides a copy of such request to the State...

  14. 45 CFR 1226.9 - Exceptions.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... the State Director on a quarterly basis of all activity occurring pursuant to this exception. (2) The... ON ELECTORAL AND LOBBYING ACTIVITIES Volunteer Activities § 1226.9 Exceptions. (a) A volunteer may... addressed. (3) The volunteer or the program sponsor provides a copy of such request to the State...

  15. 7 CFR 1779.17 - Exception authority.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 12 2010-01-01 2010-01-01 false Exception authority. 1779.17 Section 1779.17 Agriculture Regulations of the Department of Agriculture (Continued) RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE (CONTINUED) WATER AND WASTE DISPOSAL PROGRAMS GUARANTEED LOANS § 1779.17 Exception authority....

  16. 7 CFR 1955.81 - Exception authority.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 14 2011-01-01 2011-01-01 false Exception authority. 1955.81 Section 1955.81 Agriculture Regulations of the Department of Agriculture (Continued) RURAL HOUSING SERVICE, RURAL BUSINESS...) PROGRAM REGULATIONS (CONTINUED) PROPERTY MANAGEMENT Management of Property § 1955.81 Exception authority...

  17. 46 CFR 565.5 - Exceptions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 9 2010-10-01 2010-10-01 false Exceptions. 565.5 Section 565.5 Shipping FEDERAL MARITIME COMMISSION REGULATIONS AND ACTIONS TO ADDRESS RESTRICTIVE FOREIGN MARITIME PRACTICES CONTROLLED CARRIERS § 565.5 Exceptions. All controlled carriers shall be subject to provisions of this part and...

  18. The Doubly Exceptional Child: A Principal's Dilemma.

    ERIC Educational Resources Information Center

    Kesner, Rebecca J., Ed.

    2002-01-01

    This document contains two articles concerned with doubly exceptional children and gifted education. In "The Doubly Exceptional Child: A Principal's Dilemma," (Carol J. Mills and Linda E. Brody), such children do not fit into the usual categories for sorting children because their gifts and disabilities often mask each other. Suggestions are…

  19. 14 CFR 1214.807 - Exceptional payloads.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 5 2011-01-01 2010-01-01 true Exceptional payloads. 1214.807 Section 1214.807 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION SPACE FLIGHT Reimbursement for Spacelab Services § 1214.807 Exceptional payloads. Customers whose payloads qualify under the...

  20. 14 CFR 1214.807 - Exceptional payloads.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 5 2012-01-01 2012-01-01 false Exceptional payloads. 1214.807 Section 1214.807 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION SPACE FLIGHT Reimbursement for Spacelab Services § 1214.807 Exceptional payloads. Customers whose payloads qualify under the...

  1. 14 CFR 1214.807 - Exceptional payloads.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 5 2013-01-01 2013-01-01 false Exceptional payloads. 1214.807 Section 1214.807 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION SPACE FLIGHT Reimbursement for Spacelab Services § 1214.807 Exceptional payloads. Customers whose payloads qualify under the...

  2. 14 CFR 1214.807 - Exceptional payloads.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Exceptional payloads. 1214.807 Section 1214.807 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION SPACE FLIGHT Reimbursement for Spacelab Services § 1214.807 Exceptional payloads. Customers whose payloads qualify under the...

  3. 7 CFR 1955.81 - Exception authority.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 14 2012-01-01 2012-01-01 false Exception authority. 1955.81 Section 1955.81 Agriculture Regulations of the Department of Agriculture (Continued) RURAL HOUSING SERVICE, RURAL BUSINESS...) PROGRAM REGULATIONS (CONTINUED) PROPERTY MANAGEMENT Management of Property § 1955.81 Exception authority...

  4. 31 CFR 82.2 - Exceptions.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 31 Money and Finance: Treasury 1 2012-07-01 2012-07-01 false Exceptions. 82.2 Section 82.2 Money and Finance: Treasury Regulations Relating to Money and Finance MONETARY OFFICES, DEPARTMENT OF THE TREASURY 5-CENT AND ONE-CENT COIN REGULATIONS § 82.2 Exceptions. (a) The prohibition contained in §...

  5. 7 CFR 1955.81 - Exception authority.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 14 2010-01-01 2009-01-01 true Exception authority. 1955.81 Section 1955.81 Agriculture Regulations of the Department of Agriculture (Continued) RURAL HOUSING SERVICE, RURAL BUSINESS...) PROGRAM REGULATIONS (CONTINUED) PROPERTY MANAGEMENT Management of Property § 1955.81 Exception...

  6. 2 CFR 176.80 - Exceptions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 2 Grants and Agreements 1 2010-01-01 2010-01-01 false Exceptions. 176.80 Section 176.80 Grants and... manufactured goods needed in the project. (2) Unreasonable cost. The head of the Federal department or agency... manufactured goods may be used— (1) The award official shall list the excepted materials in the award; and (2...

  7. 8 CFR 286.3 - Exceptions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 8 Aliens and Nationality 1 2013-01-01 2013-01-01 false Exceptions. 286.3 Section 286.3 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS IMMIGRATION USER FEE § 286.3 Exceptions. The fees set forth in §§ 286.2(a) and 286.2(b) shall not be charged or collected from passengers...

  8. 8 CFR 286.3 - Exceptions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 8 Aliens and Nationality 1 2014-01-01 2014-01-01 false Exceptions. 286.3 Section 286.3 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS IMMIGRATION USER FEE § 286.3 Exceptions. The fees set forth in §§ 286.2(a) and 286.2(b) shall not be charged or collected from passengers...

  9. 8 CFR 286.3 - Exceptions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 8 Aliens and Nationality 1 2010-01-01 2010-01-01 false Exceptions. 286.3 Section 286.3 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS IMMIGRATION USER FEE § 286.3 Exceptions. The fees set forth in §§ 286.2(a) and 286.2(b) shall not be charged or collected from passengers...

  10. 8 CFR 286.3 - Exceptions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 8 Aliens and Nationality 1 2012-01-01 2012-01-01 false Exceptions. 286.3 Section 286.3 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS IMMIGRATION USER FEE § 286.3 Exceptions. The fees set forth in §§ 286.2(a) and 286.2(b) shall not be charged or collected from passengers...

  11. 8 CFR 286.3 - Exceptions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 8 Aliens and Nationality 1 2011-01-01 2011-01-01 false Exceptions. 286.3 Section 286.3 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS IMMIGRATION USER FEE § 286.3 Exceptions. The fees set forth in §§ 286.2(a) and 286.2(b) shall not be charged or collected from passengers...

  12. 28 CFR 63.9 - Exception.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 28 Judicial Administration 2 2014-07-01 2014-07-01 false Exception. 63.9 Section 63.9 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) FLOODPLAIN MANAGEMENT AND WETLAND PROTECTION PROCEDURES § 63.9 Exception. Nothing in these guidelines shall apply to assistance provided for emergency work essential...

  13. 28 CFR 63.9 - Exception.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Exception. 63.9 Section 63.9 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) FLOODPLAIN MANAGEMENT AND WETLAND PROTECTION PROCEDURES § 63.9 Exception. Nothing in these guidelines shall apply to assistance provided for emergency work essential...

  14. 28 CFR 63.9 - Exception.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 28 Judicial Administration 2 2013-07-01 2013-07-01 false Exception. 63.9 Section 63.9 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) FLOODPLAIN MANAGEMENT AND WETLAND PROTECTION PROCEDURES § 63.9 Exception. Nothing in these guidelines shall apply to assistance provided for emergency work essential...

  15. 28 CFR 63.9 - Exception.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 28 Judicial Administration 2 2011-07-01 2011-07-01 false Exception. 63.9 Section 63.9 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) FLOODPLAIN MANAGEMENT AND WETLAND PROTECTION PROCEDURES § 63.9 Exception. Nothing in these guidelines shall apply to assistance provided for emergency work essential...

  16. 28 CFR 63.9 - Exception.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 28 Judicial Administration 2 2012-07-01 2012-07-01 false Exception. 63.9 Section 63.9 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) FLOODPLAIN MANAGEMENT AND WETLAND PROTECTION PROCEDURES § 63.9 Exception. Nothing in these guidelines shall apply to assistance provided for emergency work essential...

  17. The Summer Learning of Exceptional Students

    ERIC Educational Resources Information Center

    Gershenson, Seth; Hayes, Michael S.

    2017-01-01

    The summer activities and summer learning of exceptional students--students who have an individualized education plan or who are English-language learners--are potentially important yet understudied. We analyze nationally representative survey data to fill this gap. Exceptional students are significantly less likely than their mainstream…

  18. 24 CFR 300.15 - Exceptions.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Exceptions. 300.15 Section 300.15 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued) GOVERNMENT NATIONAL MORTGAGE ASSOCIATION, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT GENERAL § 300.15 Exceptions....

  19. 22 CFR 513.215 - Exception provision.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 22 Foreign Relations 2 2012-04-01 2009-04-01 true Exception provision. 513.215 Section 513.215 Foreign Relations BROADCASTING BOARD OF GOVERNORS GOVERNMENT DEBARMENT AND SUSPENSION (NONPROCUREMENT) AND GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (GRANTS) Effect of Action § 513.215 Exception provision....

  20. 22 CFR 513.215 - Exception provision.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 22 Foreign Relations 2 2011-04-01 2009-04-01 true Exception provision. 513.215 Section 513.215 Foreign Relations BROADCASTING BOARD OF GOVERNORS GOVERNMENT DEBARMENT AND SUSPENSION (NONPROCUREMENT) AND GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (GRANTS) Effect of Action § 513.215 Exception provision....

  1. 22 CFR 513.215 - Exception provision.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 22 Foreign Relations 2 2013-04-01 2009-04-01 true Exception provision. 513.215 Section 513.215 Foreign Relations BROADCASTING BOARD OF GOVERNORS GOVERNMENT DEBARMENT AND SUSPENSION (NONPROCUREMENT) AND GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (GRANTS) Effect of Action § 513.215 Exception provision....

  2. 22 CFR 513.215 - Exception provision.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 22 Foreign Relations 2 2014-04-01 2014-04-01 false Exception provision. 513.215 Section 513.215 Foreign Relations BROADCASTING BOARD OF GOVERNORS GOVERNMENT DEBARMENT AND SUSPENSION (NONPROCUREMENT) AND GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (GRANTS) Effect of Action § 513.215 Exception provision....

  3. 22 CFR 513.215 - Exception provision.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 2 2010-04-01 2010-04-01 true Exception provision. 513.215 Section 513.215 Foreign Relations BROADCASTING BOARD OF GOVERNORS GOVERNMENT DEBARMENT AND SUSPENSION (NONPROCUREMENT) AND GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (GRANTS) Effect of Action § 513.215 Exception provision....

  4. 38 CFR 1.897 - Exceptions.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2013-07-01 2013-07-01 false Exceptions. 1.897 Section 1.897 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS GENERAL PROVISIONS Part-Time Career Employment Program § 1.897 Exceptions. The Secretary of Veterans Affairs, or designees,...

  5. 21 CFR 1316.66 - Exceptions.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 9 2010-04-01 2010-04-01 false Exceptions. 1316.66 Section 1316.66 Food and Drugs DRUG ENFORCEMENT ADMINISTRATION, DEPARTMENT OF JUSTICE ADMINISTRATIVE FUNCTIONS, PRACTICES, AND PROCEDURES Administrative Hearings § 1316.66 Exceptions. (a) Within twenty days after the date upon which...

  6. Twice Exceptionality from a Practitioner's Perspective

    ERIC Educational Resources Information Center

    Omdal, Stuart

    2015-01-01

    The new definition of twice exceptionality by the National Twice-Exceptional Community of Practice (2e CoP) is a tool that will facilitate communication and collaboration for practitioners in the regular classroom, gifted education specialists, administrators, and professors. In this article, the author shares his experiences in several of these…

  7. 7 CFR 1980.496 - Exception authority.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 14 2012-01-01 2012-01-01 false Exception authority. 1980.496 Section 1980.496 Agriculture Regulations of the Department of Agriculture (Continued) RURAL HOUSING SERVICE, RURAL BUSINESS...) PROGRAM REGULATIONS (CONTINUED) GENERAL Business and Industrial Loan Program § 1980.496 Exception...

  8. 7 CFR 1980.496 - Exception authority.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 14 2014-01-01 2014-01-01 false Exception authority. 1980.496 Section 1980.496 Agriculture Regulations of the Department of Agriculture (Continued) RURAL HOUSING SERVICE, RURAL BUSINESS...) PROGRAM REGULATIONS (CONTINUED) GENERAL Business and Industrial Loan Program § 1980.496 Exception...

  9. 7 CFR 1980.496 - Exception authority.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 14 2011-01-01 2011-01-01 false Exception authority. 1980.496 Section 1980.496 Agriculture Regulations of the Department of Agriculture (Continued) RURAL HOUSING SERVICE, RURAL BUSINESS...) PROGRAM REGULATIONS (CONTINUED) GENERAL Business and Industrial Loan Program § 1980.496 Exception...

  10. 48 CFR 39.204 - Exceptions.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 1 2014-10-01 2014-10-01 false Exceptions. 39.204 Section 39.204 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION SPECIAL CATEGORIES OF CONTRACTING ACQUISITION OF INFORMATION TECHNOLOGY Electronic and Information Technology 39.204 Exceptions....

  11. 45 CFR 1226.9 - Exceptions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 4 2010-10-01 2010-10-01 false Exceptions. 1226.9 Section 1226.9 Public Welfare Regulations Relating to Public Welfare (Continued) CORPORATION FOR NATIONAL AND COMMUNITY SERVICE PROHIBITIONS ON ELECTORAL AND LOBBYING ACTIVITIES Volunteer Activities § 1226.9 Exceptions. (a) A volunteer...

  12. 2 CFR 176.80 - Exceptions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 2 Grants and Agreements 1 2014-01-01 2014-01-01 false Exceptions. 176.80 Section 176.80 Grants and... project. (2) Unreasonable cost. The head of the Federal department or agency may determine that the cost... manufactured goods may be used— (1) The award official shall list the excepted materials in the award; and (2...

  13. 2 CFR 176.80 - Exceptions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 2 Grants and Agreements 1 2012-01-01 2012-01-01 false Exceptions. 176.80 Section 176.80 Grants and... manufactured goods needed in the project. (2) Unreasonable cost. The head of the Federal department or agency... manufactured goods may be used— (1) The award official shall list the excepted materials in the award; and (2...

  14. 2 CFR 176.80 - Exceptions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 2 Grants and Agreements 1 2011-01-01 2011-01-01 false Exceptions. 176.80 Section 176.80 Grants and... project. (2) Unreasonable cost. The head of the Federal department or agency may determine that the cost... manufactured goods may be used— (1) The award official shall list the excepted materials in the award; and (2...

  15. 2 CFR 176.80 - Exceptions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 2 Grants and Agreements 1 2013-01-01 2013-01-01 false Exceptions. 176.80 Section 176.80 Grants and... manufactured goods needed in the project. (2) Unreasonable cost. The head of the Federal department or agency... manufactured goods may be used— (1) The award official shall list the excepted materials in the award; and (2...

  16. 48 CFR 1503.602 - Exceptions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Exceptions. 1503.602 Section 1503.602 Federal Acquisition Regulations System ENVIRONMENTAL PROTECTION AGENCY GENERAL IMPROPER... shall consult with the Designated Agency Ethics Official before authorizing any exceptions....

  17. 78 FR 77632 - Amendments to Excepted Benefits

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-24

    ... dental benefits, and benefits for long-term care, nursing home care, home health care, or community based... excepted benefits. A. Dental and Vision Benefits In 2004, the Departments of the Treasury, Labor, and HHS... otherwise.) Under the HIPAA regulations, vision and dental benefits are excepted if they are limited...

  18. 30 CFR 75.402-2 - Exceptions.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 30 Mineral Resources 1 2014-07-01 2014-07-01 false Exceptions. 75.402-2 Section 75.402-2 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR COAL MINE SAFETY AND HEALTH MANDATORY SAFETY STANDARDS-UNDERGROUND COAL MINES Combustible Materials and Rock Dusting § 75.402-2 Exceptions...

  19. 30 CFR 75.402-2 - Exceptions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 1 2011-07-01 2011-07-01 false Exceptions. 75.402-2 Section 75.402-2 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR COAL MINE SAFETY AND HEALTH MANDATORY SAFETY STANDARDS-UNDERGROUND COAL MINES Combustible Materials and Rock Dusting § 75.402-2 Exceptions...

  20. 30 CFR 75.402-2 - Exceptions.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 30 Mineral Resources 1 2013-07-01 2013-07-01 false Exceptions. 75.402-2 Section 75.402-2 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR COAL MINE SAFETY AND HEALTH MANDATORY SAFETY STANDARDS-UNDERGROUND COAL MINES Combustible Materials and Rock Dusting § 75.402-2 Exceptions...

  1. 30 CFR 75.402-2 - Exceptions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Exceptions. 75.402-2 Section 75.402-2 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR COAL MINE SAFETY AND HEALTH MANDATORY SAFETY STANDARDS-UNDERGROUND COAL MINES Combustible Materials and Rock Dusting § 75.402-2 Exceptions...

  2. 30 CFR 75.402-2 - Exceptions.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 30 Mineral Resources 1 2012-07-01 2012-07-01 false Exceptions. 75.402-2 Section 75.402-2 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR COAL MINE SAFETY AND HEALTH MANDATORY SAFETY STANDARDS-UNDERGROUND COAL MINES Combustible Materials and Rock Dusting § 75.402-2 Exceptions...

  3. 22 CFR 53.2 - Exceptions.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... DEPARTMENT OF STATE NATIONALITY AND PASSPORTS PASSPORT REQUIREMENT AND EXCEPTIONS § 53.2 Exceptions. (a) U.S. citizens, as defined in § 41.0 of this chapter, are not required to bear U.S. passports when traveling... required to bear a valid U.S. passport to enter or depart the United States: (1) When traveling as a member...

  4. 22 CFR 53.2 - Exceptions.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... DEPARTMENT OF STATE NATIONALITY AND PASSPORTS PASSPORT REQUIREMENT AND EXCEPTIONS § 53.2 Exceptions. (a) U.S. citizens, as defined in § 41.0 of this chapter, are not required to bear U.S. passports when traveling... required to bear a valid U.S. passport to enter or depart the United States: (1) When traveling as a member...

  5. 22 CFR 53.2 - Exceptions.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... DEPARTMENT OF STATE NATIONALITY AND PASSPORTS PASSPORT REQUIREMENT AND EXCEPTIONS § 53.2 Exceptions. (a) U.S. citizens, as defined in § 41.0 of this chapter, are not required to bear U.S. passports when traveling... required to bear a valid U.S. passport to enter or depart the United States: (1) When traveling as a member...

  6. 31 CFR 82.2 - Exceptions.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 31 Money and Finance: Treasury 1 2014-07-01 2014-07-01 false Exceptions. 82.2 Section 82.2 Money and Finance: Treasury Regulations Relating to Money and Finance MONETARY OFFICES, DEPARTMENT OF THE TREASURY 5-CENT AND ONE-CENT COIN REGULATIONS § 82.2 Exceptions. (a) The prohibition contained in §...

  7. 31 CFR 82.2 - Exceptions.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 31 Money and Finance: Treasury 1 2013-07-01 2013-07-01 false Exceptions. 82.2 Section 82.2 Money and Finance: Treasury Regulations Relating to Money and Finance MONETARY OFFICES, DEPARTMENT OF THE TREASURY 5-CENT AND ONE-CENT COIN REGULATIONS § 82.2 Exceptions. (a) The prohibition contained in §...

  8. 45 CFR 148.220 - Excepted benefits.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... FOR THE INDIVIDUAL HEALTH INSURANCE MARKET Preemption; Excepted Benefits § 148.220 Excepted benefits. The requirements of this part do not apply to individual health insurance coverage in relation to its... part do not apply to individual health insurance coverage described in paragraphs (b)(1) through...

  9. 45 CFR 148.220 - Excepted benefits.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... FOR THE INDIVIDUAL HEALTH INSURANCE MARKET Preemption; Excepted Benefits § 148.220 Excepted benefits. The requirements of this part do not apply to individual health insurance coverage in relation to its... part do not apply to individual health insurance coverage described in paragraphs (b)(1) through...

  10. 48 CFR 925.103 - Exceptions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Exceptions. 925.103 Section 925.103 Federal Acquisition Regulations System DEPARTMENT OF ENERGY SOCIOECONOMIC PROGRAMS FOREIGN ACQUISITION Buy American Act-Supplies 925.103 Exceptions. (a) Contracting officers may make the...

  11. 48 CFR 825.103 - Exceptions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Exceptions. 825.103 Section 825.103 Federal Acquisition Regulations System DEPARTMENT OF VETERANS AFFAIRS SOCIOECONOMIC PROGRAMS FOREIGN ACQUISITION Buy American Act-Supplies 825.103 Exceptions. (a) Public interest. When...

  12. 48 CFR 1425.103 - Exceptions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Exceptions. 1425.103 Section 1425.103 Federal Acquisition Regulations System DEPARTMENT OF THE INTERIOR SOCIOECONOMIC PROGRAMS FOREIGN ACQUISITION Buy American Act-Supplies 1425.103 Exceptions. (a) The AS/PMB is authorized to...

  13. 32 CFR 536.45 - Statutory exceptions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 3 2010-07-01 2010-07-01 true Statutory exceptions. 536.45 Section 536.45 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY CLAIMS AND ACCOUNTS CLAIMS AGAINST THE UNITED STATES Investigation and Processing of Claims § 536.45 Statutory exceptions. This topic is more fully discussed in DA Pam...

  14. 7 CFR 4280.104 - Exception authority.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 15 2010-01-01 2010-01-01 false Exception authority. 4280.104 Section 4280.104 Agriculture Regulations of the Department of Agriculture (Continued) RURAL BUSINESS-COOPERATIVE SERVICE AND... Efficiency Improvements Program § 4280.104 Exception authority. The Administrator may, on a...

  15. A 2014 nationwide survey of the distribution of Soybean mosaic virus (SMV), Soybean yellow mottle mosaic virus (SYMMV) and Soybean yellow common mosaic virus (SYCMV) major viruses in South Korean soybean fields, and changes

    USDA-ARS?s Scientific Manuscript database

    In 2014 symptomatic soybean samples were collected throughout Korea, and were tested for the most important soybean viruses found in Korea, namely Soybean mosaic virus (SMV), Soybean yellow common mosaic virus (SYCMV), and Soybean yellow mottle mosaic virus (SYMMV). SYMMV was most commonly detected,...

  16. QCI Common

    SciTech Connect

    McCaskey, Alexander J.

    2016-11-18

    There are many common software patterns and utilities for the ORNL Quantum Computing Institute that can and should be shared across projects. Otherwise we find duplication of code which adds unwanted complexity. This is a software product seeks to alleviate this by providing common utilities such as object factories, graph data structures, parameter input mechanisms, etc., for other software products within the ORNL Quantum Computing Institute. This work enables pure basic research, has no export controlled utilities, and has no real commercial value.

  17. Exceptional supergravity theories and the magic square

    NASA Astrophysics Data System (ADS)

    Günaydin, M.; Sierra, G.; Townsend, P. K.

    1983-12-01

    We derive the magic square of Freudenthal, Rozenfeld, and Tits from the geometry of a special class of N=2 Maxwell-Einstein supergravity theories. We also show that all of these theories are obtainable by truncation of N=8 supergravity theories in various spacetime dimensions d, except for an ``exceptional'' subclass, unique for a given d, which is associated with with the exceptional Jordan algebra of 3 × 3 hermitian octonionic matrices. Laboratoire Propre du Centre National de la Recherche Scientifique, associé à l'Ecole Normale Supérieure et à l'Université de Paris-Sud.

  18. The Exception Does Not Rule: Attention Constrains Form Preparation in Word Production

    PubMed Central

    O’Séaghdha, Pádraig G.; Frazer, Alexandra K.

    2014-01-01

    Form preparation in word production, the benefit of exploiting a useful common sound (such as the first phoneme) of iteratively spoken small groups of words, is notoriously fastidious, exhibiting a seemingly categorical, all-or-none character, and a corresponding susceptibility to ‘killers’ of preparation. In particular, the presence of a single exception item in a group of otherwise phonologically consistent words has been found to eliminate the benefit of knowing a majority characteristic. This has been interpreted to mean that form preparation amounts to partial production, and thus provides a window on fundamental processes of phonological word encoding (e.g., Levelt et al., 1999). However, preparation of only fully distributed properties appears to be non-optimal, and is difficult to reconcile with the sensitivity of cognitive responses to probabilities in other domains. We show here that the all-or-none characteristic of form preparation is specific to task format. Preparation for sets that included an exception item occurred in ecologically valid production tasks, picture naming (Experiment 1), and word naming (Experiment 2). Preparation failed only in the commonly used, but indirect and resource-intensive, associative cuing task (Experiment 3). We outline an account of form preparation in which anticipation of word-initial phonological fragments uses a limited capacity, sustained attentional capability that points to rather than enacts possibilities for imminent speech. PMID:24548328

  19. 14 CFR 255.6 - Exceptions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... and Space OFFICE OF THE SECRETARY, DEPARTMENT OF TRANSPORTATION (AVIATION PROCEEDINGS) ECONOMIC REGULATIONS AIRLINE COMPUTER RESERVATIONS SYSTEMS § 255.6 Exceptions. The obligations of a system under § 255... participating airline contract with that system. ...

  20. 7 CFR 1944.75 - Exception authority.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... exercise this authority only at the request of the State Director and recommendation of the Deputy Administrator, Single Family Housing. Requests for exceptions must be in writing by the State Director...

  1. 7 CFR 1944.75 - Exception authority.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... exercise this authority only at the request of the State Director and recommendation of the Deputy Administrator, Single Family Housing. Requests for exceptions must be in writing by the State Director...

  2. 7 CFR 1944.75 - Exception authority.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... exercise this authority only at the request of the State Director and recommendation of the Deputy Administrator, Single Family Housing. Requests for exceptions must be in writing by the State Director...

  3. 48 CFR 8.503 - Exception.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... REQUIRED SOURCES OF SUPPLIES AND SERVICES Acquisition of Helium 8.503 Exception. The requirements of this subpart do not apply to contracts or subcontracts in which the helium was acquired by the contractor prior...

  4. 48 CFR 8.503 - Exception.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... REQUIRED SOURCES OF SUPPLIES AND SERVICES Acquisition of Helium 8.503 Exception. The requirements of this subpart do not apply to contracts or subcontracts in which the helium was acquired by the contractor prior...

  5. 48 CFR 8.503 - Exception.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... REQUIRED SOURCES OF SUPPLIES AND SERVICES Acquisition of Helium 8.503 Exception. The requirements of this subpart do not apply to contracts or subcontracts in which the helium was acquired by the contractor prior...

  6. 48 CFR 8.503 - Exception.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... REQUIRED SOURCES OF SUPPLIES AND SERVICES Acquisition of Helium 8.503 Exception. The requirements of this subpart do not apply to contracts or subcontracts in which the helium was acquired by the contractor prior...

  7. 48 CFR 8.503 - Exception.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... REQUIRED SOURCES OF SUPPLIES AND SERVICES Acquisition of Helium 8.503 Exception. The requirements of this subpart do not apply to contracts or subcontracts in which the helium was acquired by the contractor prior...

  8. 33 CFR 183.715 - Exception.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... information must be displayed on the motor: “Warning—Ensure shift control is in neutral before starting motor... SAFETY BOATS AND ASSOCIATED EQUIPMENT Start-in-Gear Protection § 183.715 Exception. Outboard motors...

  9. 48 CFR 225.103 - Exceptions.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Logistics) has determined that it is inconsistent with the public interest to apply the Buy American statute... not to impair integration of the military and commercial industrial base. (B) Except as provided in...

  10. 48 CFR 9.304 - Exceptions.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... CONTRACTOR QUALIFICATIONS First Article Testing and Approval 9.304 Exceptions. Normally, testing and approval is not required in contracts for— (a) Research or development; (b) Products requiring qualification... would meet the requirements without testing and approval....

  11. 48 CFR 9.304 - Exceptions.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... CONTRACTOR QUALIFICATIONS First Article Testing and Approval 9.304 Exceptions. Normally, testing and approval is not required in contracts for— (a) Research or development; (b) Products requiring qualification... would meet the requirements without testing and approval....

  12. 48 CFR 9.304 - Exceptions.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... CONTRACTOR QUALIFICATIONS First Article Testing and Approval 9.304 Exceptions. Normally, testing and approval is not required in contracts for— (a) Research or development; (b) Products requiring qualification... would meet the requirements without testing and approval....

  13. 48 CFR 9.304 - Exceptions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... CONTRACTOR QUALIFICATIONS First Article Testing and Approval 9.304 Exceptions. Normally, testing and approval is not required in contracts for— (a) Research or development; (b) Products requiring qualification... would meet the requirements without testing and approval....

  14. 48 CFR 9.304 - Exceptions.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... CONTRACTOR QUALIFICATIONS First Article Testing and Approval 9.304 Exceptions. Normally, testing and approval is not required in contracts for— (a) Research or development; (b) Products requiring qualification... would meet the requirements without testing and approval....

  15. 48 CFR 1425.103 - Exceptions.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... FOREIGN ACQUISITION Buy American Act-Supplies 1425.103 Exceptions. (a) The AS/PMB is authorized to make... authorized to make the determination that an article, material or supply not included in the list under FAR...

  16. 14 CFR 255.6 - Exceptions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... and Space OFFICE OF THE SECRETARY, DEPARTMENT OF TRANSPORTATION (AVIATION PROCEEDINGS) ECONOMIC REGULATIONS AIRLINE COMPUTER RESERVATIONS SYSTEMS § 255.6 Exceptions. The obligations of a system under § 255... participating airline contract with that system. ...

  17. 7 CFR 1782.22 - Exception authority.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... AGRICULTURE (CONTINUED) SERVICING OF WATER AND WASTE PROGRAMS § 1782.22 Exception authority. The Administrator... inconsistent with the authorizing statute or other applicable law and is determined to be in the...

  18. 7 CFR 1780.25 - Exception authority.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... AGRICULTURE (CONTINUED) WATER AND WASTE LOANS AND GRANTS General Policies and Requirements § 1780.25 Exception... this part which is not inconsistent with the authorizing statute or other applicable law and...

  19. 7 CFR 1779.17 - Exception authority.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... AGRICULTURE (CONTINUED) WATER AND WASTE DISPOSAL PROGRAMS GUARANTEED LOANS § 1779.17 Exception authority. The... not inconsistent with the authorizing statute or other applicable law and is determined to be in...

  20. 7 CFR 1779.17 - Exception authority.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... AGRICULTURE (CONTINUED) WATER AND WASTE DISPOSAL PROGRAMS GUARANTEED LOANS § 1779.17 Exception authority. The... not inconsistent with the authorizing statute or other applicable law and is determined to be in...

  1. 32 CFR 811.1 - Exceptions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... SALE OF VISUAL INFORMATION MATERIALS § 811.1 Exceptions. The regulations in this part do not apply to: (a) Visual information (VI) materials made for the Air Force Office of Special Investigations for use...

  2. 48 CFR 217.7402 - Exceptions.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Actions 217.7402 Exceptions. (a) The following undefinitized contract actions (UCAs) are not subject to... maximum extent practicable (also see paragraph (b) of this section): (1) UCAs for foreign military sales...

  3. 48 CFR 217.7402 - Exceptions.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Actions 217.7402 Exceptions. (a) The following undefinitized contract actions (UCAs) are not subject to... maximum extent practicable (also see paragraph (b) of this section): (1) UCAs for foreign military sales...

  4. 48 CFR 217.7402 - Exceptions.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Actions 217.7402 Exceptions. (a) The following undefinitized contract actions (UCAs) are not subject to... maximum extent practicable (also see paragraph (b) of this section): (1) UCAs for foreign military sales...

  5. 48 CFR 217.7402 - Exceptions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Actions 217.7402 Exceptions. (a) The following undefinitized contract actions (UCAs) are not subject to... maximum extent practicable (also see paragraph (b) of this section): (1) UCAs for foreign military sales...

  6. 48 CFR 217.7402 - Exceptions.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Actions 217.7402 Exceptions. (a) The following undefinitized contract actions (UCAs) are not subject to... maximum extent practicable (also see paragraph (b) of this section): (1) UCAs for foreign military sales...

  7. The Exceptional Environment: Strategies for Design

    ERIC Educational Resources Information Center

    Spivack, Mayer

    1974-01-01

    Author addressed himself to the problem of designing effective environments for exceptional children. He developed essential "polar paradigms" for the observation of children's behavior in relation to their physical setting. (Editor/RK)

  8. 15 CFR 905.5 - Exceptions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... PROCEEDINGS OF INFORMATION COLLECTED BY VOLUNTARY FISHERY DATA COLLECTORS § 905.5 Exceptions. The provisions... person; or (b) Impairment or interference with the duties of a voluntary fishery data collector....

  9. 15 CFR 905.5 - Exceptions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... PROCEEDINGS OF INFORMATION COLLECTED BY VOLUNTARY FISHERY DATA COLLECTORS § 905.5 Exceptions. The provisions... person; or (b) Impairment or interference with the duties of a voluntary fishery data collector....

  10. 15 CFR 905.5 - Exceptions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... PROCEEDINGS OF INFORMATION COLLECTED BY VOLUNTARY FISHERY DATA COLLECTORS § 905.5 Exceptions. The provisions... person; or (b) Impairment or interference with the duties of a voluntary fishery data collector....

  11. 15 CFR 905.5 - Exceptions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... PROCEEDINGS OF INFORMATION COLLECTED BY VOLUNTARY FISHERY DATA COLLECTORS § 905.5 Exceptions. The provisions... person; or (b) Impairment or interference with the duties of a voluntary fishery data collector....

  12. 15 CFR 905.5 - Exceptions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... PROCEEDINGS OF INFORMATION COLLECTED BY VOLUNTARY FISHERY DATA COLLECTORS § 905.5 Exceptions. The provisions... person; or (b) Impairment or interference with the duties of a voluntary fishery data collector....

  13. 33 CFR 175.115 - Exceptions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... SAFETY EQUIPMENT REQUIREMENTS Visual Distress Signals § 175.115 Exceptions. The following persons need not comply with § 175.110; however, each must carry on board visual distress signals suitable...

  14. 44 CFR 17.625 - Exception provision.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... HOMELAND SECURITY GENERAL GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (GRANTS) § 17.625 Exception provision. The agency head may waive with respect to a particular grant, in writing, a suspension of...

  15. 22 CFR 513.625 - Exception provision.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (GRANTS) Drug-Free Workplace Requirements (Grants) § 513.625 Exception provision. The Board head may waive with respect to a particular grant, in writing, a suspension...

  16. 48 CFR 225.103 - Exceptions.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... interest exceptions for certain countries are in 225.872. (B) For procurements covered by the World Trade Organization Government Procurement Agreement, the Under Secretary of Defense (Acquisition, Technology,...

  17. 48 CFR 225.103 - Exceptions.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... interest exceptions for certain countries are in 225.872. (B) For procurements covered by the World Trade Organization Government Procurement Agreement, the Under Secretary of Defense (Acquisition, Technology,...

  18. 31 CFR 101.7 - Exceptions.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... TREASURY MITIGATION OF FORFEITURE OF COUNTERFEIT GOLD COINS § 101.7 Exceptions. The provisions of this part shall not apply where the cost of smelting the gold coins exceeds the value of the gold bullion to...

  19. 31 CFR 101.7 - Exceptions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... TREASURY MITIGATION OF FORFEITURE OF COUNTERFEIT GOLD COINS § 101.7 Exceptions. The provisions of this part shall not apply where the cost of smelting the gold coins exceeds the value of the gold bullion to...

  20. 31 CFR 101.7 - Exceptions.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... TREASURY MITIGATION OF FORFEITURE OF COUNTERFEIT GOLD COINS § 101.7 Exceptions. The provisions of this part shall not apply where the cost of smelting the gold coins exceeds the value of the gold bullion to...

  1. 31 CFR 101.7 - Exceptions.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... TREASURY MITIGATION OF FORFEITURE OF COUNTERFEIT GOLD COINS § 101.7 Exceptions. The provisions of this part shall not apply where the cost of smelting the gold coins exceeds the value of the gold bullion to...

  2. Major depression

    MedlinePlus

    ... death or illness of someone close to you, divorce, childhood abuse or neglect, loneliness (common in older ... your provider. Ask your provider about possible side effects, and what to do if you have any. ...

  3. THE CONCEPT OF EXCEPTIONALITY: A LEGAL FARCE?

    PubMed Central

    Ford, Amy

    2012-01-01

    How do we decide which treatments should be offered by the National Health Service (NHS) when we cannot afford to fund them all? In the absence of a positive appraisal by the National Institute for Health and Clinical Excellence (NICE), which mandates the provision of a treatment by the NHS, Primary Care Trusts (PCTs) are free to decide whether to provide a particular drug to some, or all, of their population. However, as public bodies, it is a well-established principle of Administrative Law that PCTs are not at liberty to fetter the exercise of their own discretion. They must recognise the possibility that some patients will have exceptional circumstances, and as a consequence, any general policy prohibiting the funding of a drug cannot be absolute. In the absence of statutory guidance on what might constitute exceptional, clinicians are left guessing as to whether their patients might be eligible for funding on the grounds of exceptionality. Using the context of expensive cancer drugs, I will examine the concept of exceptionality from clinical, moral, and legal perspectives, focussing particularly on the role of social factors in determining exceptionality. I will review the cases where PCTs' decisions not to fund cancer drugs were subject to legal action and argue that the courts have provided little guidance on interpreting the term exceptional, and that the concept has a limited role to play in the allocation of scarce health resources at a local level. PMID:22389444

  4. Major Links.

    ERIC Educational Resources Information Center

    Henderson, Tona

    1995-01-01

    Provides electronic mail addresses for resources and discussion groups related to the following academic majors: art, biology, business, chemistry, computer science, economics, health sciences, history, literature, math, music, philosophy, political science, psychology, sociology, and theater. (AEF)

  5. Major Links.

    ERIC Educational Resources Information Center

    Henderson, Tona

    1995-01-01

    Provides electronic mail addresses for resources and discussion groups related to the following academic majors: art, biology, business, chemistry, computer science, economics, health sciences, history, literature, math, music, philosophy, political science, psychology, sociology, and theater. (AEF)

  6. Major appliance management report

    SciTech Connect

    Robertson, M.; O`Donnell, K.F.

    1990-07-15

    Major appliances (also called `white goods`) have long been managed as part of the traditional municipal solid waste (MSW) stream, with the most common management method being landfill disposal. Over the past several years, it has become increasingly apparent that major appliances are not easily or best managed along with MSW. Indiscriminate disposal of major appliances can cause environmental problems and unnecessary use of scarce landfill space as well as wasting valuable recyclable materials. In recognition of these factors, the 1989 Minnesota Legislature took a number of steps to shift the management of major appliances towards separate handling and recycling.

  7. Occurrance in Korea of three major soybean viruses, Soybean mosaic virus (SMV), Soybean yellow mottle mosaic virus (SYCMV), and Soybean yellow common mosaic virus (SYCMV) revealed by a nationwide survey of soybean fields

    USDA-ARS?s Scientific Manuscript database

    Soybean yellow mottle mosaic virus (SYMMV) and soybean yellow common mosaic virus (SYCMV) were recently isolated in Korea, and it hasn’t been reported how these two viruses were dispersed in Korea. In 2012, we performed a nationwide survey of subsistence soybean farms in Korea. Leaves that appeared ...

  8. Common clay and shale

    USGS Publications Warehouse

    Virta, R.L.

    2006-01-01

    At present, 150 companies produce common clay and shale in 41 US states. According to the United States Geological Survey (USGS), domestic production in 2005 reached 24.8 Mt valued at $176 million. In decreasing order by tonnage, the leading producer states include North Carolina, Texas, Alabama, Georgia and Ohio. For the whole year, residential and commercial building construction remained the major market for common clay and shale products such as brick, drain tile, lightweight aggregate, quarry tile and structural tile.

  9. Making the Common Good Common

    ERIC Educational Resources Information Center

    Chase, Barbara

    2011-01-01

    How are independent schools to be useful to the wider world? Beyond their common commitment to educate their students for meaningful lives in service of the greater good, can they educate a broader constituency and, thus, share their resources and skills more broadly? Their answers to this question will be shaped by their independence. Any…

  10. Amendments to excepted benefits. Final rules.

    PubMed

    2014-10-01

    This document contains final regulations that amend the regulations regarding excepted benefits under the Employee Retirement Income Security Act of 1974, the Internal Revenue Code (the Code), and the Public Health Service Act. Excepted benefits are generally exempt from the health reform requirements that were added to those laws by the Health Insurance Portability and Accountability Act and the Patient Protection and Affordable Care Act. In addition, eligibility for excepted benefits does not preclude an individual from eligibility for a premium tax credit under section 36B of the Code if an individual chooses to enroll in coverage under a Qualified Health Plan through an Affordable Insurance Exchange. These regulations finalize some but not all of the proposed rules with minor modifications; additional guidance on limited wraparound coverage is forthcoming.

  11. Exceptional points in anisotropic planar microcavities

    NASA Astrophysics Data System (ADS)

    Richter, Steffen; Michalsky, Tom; Sturm, Chris; Rosenow, Bernd; Grundmann, Marius; Schmidt-Grund, Rüdiger

    2017-02-01

    Planar microcavities allow the control and manipulation of spin polarization, manifested in phenomena like the optical spin Hall effect due to the intrinsic polarization mode splitting. Here, we study a transparent microcavity with broken rotational symmetry, realized by aligning the optic axis of a uniaxial cavity material in the cavity plane, giving rise to exceptional points in the dispersion relation. These occur pairwise, are circularly polarized, and are cores of polarization vortices. The exceptional points are result of the non-Hermitian character of the system and are in close relationship to singular optic axes in absorptive biaxial systems.

  12. A geometric formulation of exceptional field theory

    NASA Astrophysics Data System (ADS)

    du Bosque, Pascal; Hassler, Falk; Lüst, Dieter; Malek, Emanuel

    2017-03-01

    We formulate the full bosonic SL(5) exceptional field theory in a coordinateinvariant manner. Thereby we interpret the 10-dimensional extended space as a manifold with SL(5) × ℝ +-structure. We show that the algebra of generalised diffeomorphisms closes subject to a set of closure constraints which are reminiscent of the quadratic and linear constraints of maximal seven-dimensional gauged supergravities, as well as the section condition. We construct an action for the full bosonic SL(5) exceptional field theory, even when the SL(5) × ℝ +-structure is not locally flat.

  13. Syrtis Major

    NASA Image and Video Library

    2002-05-23

    This image from NASA Mars Odyssey spacecraft is from the region of Syrtis Major, which is dominated by a low-relief shield volcano and believed to be an area of vigorous aeolian activity with strong winds in the east-west direction.

  14. Major Andre

    ERIC Educational Resources Information Center

    Henisch, B. A.; Henisch, H. K.

    1976-01-01

    If most Revolutionary era people seem two-dimensional their lives simpler to understand than ours, it may be only that history, with the benefit of hindsight, clarifies. Examines a profile of Major John Andre, the British liaison officer in Benedict Arnold's plan to surrender West Point, as both hero and villain to show the complexity of early…

  15. Circulating leptin and adiponectin concentrations in healthy exceptional longevity.

    PubMed

    Pareja-Galeano, Helios; Santos-Lozano, Alejandro; Sanchis-Gomar, Fabian; Fiuza-Luces, Carmen; Garatachea, Nuria; Gálvez, Beatriz G; Lucia, Alejandro; Emanuele, Enzo

    2017-03-01

    People reaching exceptional longevity free of major age-related diseases represent the paradigm of successful aging. Adipose tissue function declines as we age, potentially resulting in changes of circulating adipokines (e.g., leptin and adiponectin). Here, we measured circulating levels of leptin and adiponectin in healthy centenarians (n=81; 100-104 years) and younger elderly controls (n=46; 70-80 years). Centenarians had significant higher serum levels of leptin compared with controls (p<0.001), whereas no significant differences were observed for adiponectin. Further research including also other blood variables will be needed to elucidate whether high leptin levels could serve as a hallmark of healthy exceptional longevity. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  16. 24 CFR 51.105 - Exceptions.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... noise attenuation measures that would normally be required for new construction in the Ldn 65 to Ldn 70... ENVIRONMENTAL CRITERIA AND STANDARDS Noise Abatement and Control § 51.105 Exceptions. (a) Flexibility for non... Statement under provisions of § 51.104(b)(1) and noise is the only environmental issue. (2) The project has...

  17. 14 CFR 93.133 - Exceptions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 2 2012-01-01 2012-01-01 false Exceptions. 93.133 Section 93.133 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIR TRAFFIC AND GENERAL OPERATING RULES SPECIAL AIR TRAFFIC RULES High Density Traffic Airports § 93.133...

  18. 14 CFR 93.133 - Exceptions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 2 2011-01-01 2011-01-01 false Exceptions. 93.133 Section 93.133 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIR TRAFFIC AND GENERAL OPERATING RULES SPECIAL AIR TRAFFIC RULES High Density Traffic Airports § 93.133...

  19. 14 CFR 93.133 - Exceptions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 2 2014-01-01 2014-01-01 false Exceptions. 93.133 Section 93.133 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIR TRAFFIC AND GENERAL OPERATING RULES SPECIAL AIR TRAFFIC RULES High Density Traffic Airports § 93.133...

  20. 14 CFR 93.133 - Exceptions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 2 2013-01-01 2013-01-01 false Exceptions. 93.133 Section 93.133 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIR TRAFFIC AND GENERAL OPERATING RULES SPECIAL AIR TRAFFIC RULES High Density Traffic Airports § 93.133...

  1. 47 CFR 76.106 - Exceptions.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 47 Telecommunication 4 2013-10-01 2013-10-01 false Exceptions. 76.106 Section 76.106 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) BROADCAST RADIO SERVICES MULTICHANNEL VIDEO AND CABLE TELEVISION SERVICE Network Non-duplication Protection, Syndicated Exclusivity and Sports Blackout...

  2. 45 CFR 1226.9 - Exceptions.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... organization to which the volunteer is assigned or placed, and signed by a member or members of the legislative... program to which he or she is assigned: Provided: (1) The sponsor organization provides notification to... structure of the project or program. (c) Notwithstanding the foregoing exceptions, any activity by a...

  3. Curriculum Guides: Exceptional Child Bibliography Series.

    ERIC Educational Resources Information Center

    Council for Exceptional Children, Reston, VA. Information Center on Exceptional Children.

    The bibliography contains references to curriculum guides selected from Exceptional Child Education Abstracts. One in a series of over 50 similar selected listings, the bibliography cites curriculum guides primarily applicable to the education of the mentally handicapped, aurally handicapped, learning disabled, or gifted. Each entry contains…

  4. Diagnostic Teaching: Exceptional Child Bibliography Series.

    ERIC Educational Resources Information Center

    Council for Exceptional Children, Reston, VA. Information Center on Exceptional Children.

    Sixty-six references selected from Exceptional Child Education Abstracts are included in the annotated bibliography on diagnostic teaching, one in a series of over 50 similar listings dealing with handicapped and gifted children. For each entry, bibliographic data, availability information, indexing and retrieval descriptors, and an abstract are…

  5. 49 CFR 391.2 - General exceptions.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... commercial motor vehicle is used to— (1) Transport farm machinery, supplies, or both, to or from a farm for custom-harvesting operations on a farm; or (2) Transport custom-harvested crops to storage or market. (b... AND LONGER COMBINATION VEHICLE (LCV) DRIVER INSTRUCTORS General § 391.2 General exceptions. (a)...

  6. 26 CFR 1.307-2 - Exception.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... TAXES Effects on Recipients § 1.307-2 Exception. The basis of rights to buy stock which are excluded from gross income under section 305(a), shall be zero if the fair market value of such rights on the date of distribution is less than 15 percent of the fair market value of the old stock on that date...

  7. 26 CFR 1.307-2 - Exception.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... TAXES (CONTINUED) Effects on Recipients § 1.307-2 Exception. The basis of rights to buy stock which are excluded from gross income under section 305(a), shall be zero if the fair market value of such rights on the date of distribution is less than 15 percent of the fair market value of the old stock on that...

  8. 7 CFR 1775.68 - Exception authority.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 12 2012-01-01 2012-01-01 false Exception authority. 1775.68 Section 1775.68 Agriculture Regulations of the Department of Agriculture (Continued) RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE (CONTINUED) TECHNICAL ASSISTANCE GRANTS Solid Waste Management Grants § 1775.68...

  9. 7 CFR 1775.68 - Exception authority.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 12 2011-01-01 2011-01-01 false Exception authority. 1775.68 Section 1775.68 Agriculture Regulations of the Department of Agriculture (Continued) RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE (CONTINUED) TECHNICAL ASSISTANCE GRANTS Solid Waste Management Grants § 1775.68...

  10. 7 CFR 1775.68 - Exception authority.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 12 2010-01-01 2010-01-01 false Exception authority. 1775.68 Section 1775.68 Agriculture Regulations of the Department of Agriculture (Continued) RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE (CONTINUED) TECHNICAL ASSISTANCE GRANTS Solid Waste Management Grants § 1775.68...

  11. 7 CFR 1775.68 - Exception authority.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 12 2014-01-01 2013-01-01 true Exception authority. 1775.68 Section 1775.68 Agriculture Regulations of the Department of Agriculture (Continued) RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE (CONTINUED) TECHNICAL ASSISTANCE GRANTS Solid Waste Management Grants § 1775.68...

  12. 7 CFR 1775.68 - Exception authority.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 12 2013-01-01 2013-01-01 false Exception authority. 1775.68 Section 1775.68 Agriculture Regulations of the Department of Agriculture (Continued) RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE (CONTINUED) TECHNICAL ASSISTANCE GRANTS Solid Waste Management Grants § 1775.68...

  13. 47 CFR 76.106 - Exceptions.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 47 Telecommunication 4 2012-10-01 2012-10-01 false Exceptions. 76.106 Section 76.106 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) BROADCAST RADIO SERVICES MULTICHANNEL VIDEO AND CABLE TELEVISION SERVICE Network Non-duplication Protection, Syndicated Exclusivity and Sports...

  14. 47 CFR 76.106 - Exceptions.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 4 2014-10-01 2014-10-01 false Exceptions. 76.106 Section 76.106 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) BROADCAST RADIO SERVICES MULTICHANNEL VIDEO AND CABLE TELEVISION SERVICE Network Non-duplication Protection, Syndicated Exclusivity and Sports...

  15. Administrative Manual: Programs for Exceptional Children.

    ERIC Educational Resources Information Center

    Delaware State Dept. of Public Instruction, Dover. Exceptional Children/Special Programs Div.

    This manual incorporates the Delaware State Board of Education's rules and regulations governing the education of exceptional children and is intended to provide guidance and information to educators, administrators, parents, and the public. The section on handicapped children covers the following areas: access to special education and related…

  16. Counseling with Mothers of Exceptional Children

    ERIC Educational Resources Information Center

    Kaplan, Bert L.

    1971-01-01

    It is possible for elementary school guidance counselors to help mothers of exceptional children face the severe reality demands they experience as internal turmoil marked by anger guilt and self depreciation. Once their feelings have been elicited and legitimized exploration of how feelings influence behavior toward children becomes possible.…

  17. 12 CFR 261a.12 - Exceptions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Banking FEDERAL RESERVE SYSTEM (CONTINUED) BOARD OF GOVERNORS OF THE FEDERAL RESERVE SYSTEM RULES... Individual to Whom Record Pertains § 261a.12 Exceptions. The restrictions on disclosure in § 261a.11 of this... for the record in the performance of their duties; (b) That is required under the Freedom of...

  18. 48 CFR 1404.7003 - Exceptions.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... MATTERS Deposit of Contract Publications 1404.7003 Exceptions. The following types of publications are... operational purposes that have no public interest, educational, scientific, or research value; (b) Classified publications and material otherwise marked prohibiting unauthorized disclosure; (c) Tentative drafts such as...

  19. 48 CFR 1404.7003 - Exceptions.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... MATTERS Deposit of Contract Publications 1404.7003 Exceptions. The following types of publications are... operational purposes that have no public interest, educational, scientific, or research value; (b) Classified publications and material otherwise marked prohibiting unauthorized disclosure; (c) Tentative drafts such as...

  20. 48 CFR 1404.7003 - Exceptions.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... MATTERS Deposit of Contract Publications 1404.7003 Exceptions. The following types of publications are... operational purposes that have no public interest, educational, scientific, or research value; (b) Classified publications and material otherwise marked prohibiting unauthorized disclosure; (c) Tentative drafts such as...

  1. 24 CFR 51.105 - Exceptions.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... all the following conditions are satisfied: (1) The project does not require an Environmental Impact Statement under provisions of § 51.104(b)(1) and noise is the only environmental issue. (2) The project has... ENVIRONMENTAL CRITERIA AND STANDARDS Noise Abatement and Control § 51.105 Exceptions. (a) Flexibility for non...

  2. 24 CFR 51.105 - Exceptions.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... all the following conditions are satisfied: (1) The project does not require an Environmental Impact Statement under provisions of § 51.104(b)(1) and noise is the only environmental issue. (2) The project has... ENVIRONMENTAL CRITERIA AND STANDARDS Noise Abatement and Control § 51.105 Exceptions. (a) Flexibility for non...

  3. 24 CFR 51.105 - Exceptions.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... all the following conditions are satisfied: (1) The project does not require an Environmental Impact Statement under provisions of § 51.104(b)(1) and noise is the only environmental issue. (2) The project has... ENVIRONMENTAL CRITERIA AND STANDARDS Noise Abatement and Control § 51.105 Exceptions. (a) Flexibility for non...

  4. 40 CFR 60.593a - Exceptions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... following exceptions to the provisions of subpart VVa of this part. (b)(1) Compressors in hydrogen service... is in hydrogen service. (2) Each compressor is presumed not to be in hydrogen service unless an owner or operator demonstrates that the piece of equipment is in hydrogen service. For a piece of...

  5. 40 CFR 60.593a - Exceptions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... following exceptions to the provisions of subpart VVa of this part. (b)(1) Compressors in hydrogen service... is in hydrogen service. (2) Each compressor is presumed not to be in hydrogen service unless an owner or operator demonstrates that the piece of equipment is in hydrogen service. For a piece of...

  6. 40 CFR 60.593a - Exceptions.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... following exceptions to the provisions of subpart VVa of this part. (b)(1) Compressors in hydrogen service... is in hydrogen service. (2) Each compressor is presumed not to be in hydrogen service unless an owner or operator demonstrates that the piece of equipment is in hydrogen service. For a piece of...

  7. 40 CFR 60.593a - Exceptions.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... following exceptions to the provisions of subpart VVa of this part. (b)(1) Compressors in hydrogen service... is in hydrogen service. (2) Each compressor is presumed not to be in hydrogen service unless an owner or operator demonstrates that the piece of equipment is in hydrogen service. For a piece of...

  8. 40 CFR 60.593a - Exceptions.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... following exceptions to the provisions of subpart VVa of this part. (b)(1) Compressors in hydrogen service... is in hydrogen service. (2) Each compressor is presumed not to be in hydrogen service unless an owner or operator demonstrates that the piece of equipment is in hydrogen service. For a piece of...

  9. 24 CFR 51.105 - Exceptions.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... all the following conditions are satisfied: (1) The project does not require an Environmental Impact Statement under provisions of § 51.104(b)(1) and noise is the only environmental issue. (2) The project has... ENVIRONMENTAL CRITERIA AND STANDARDS Noise Abatement and Control § 51.105 Exceptions. (a) Flexibility for non...

  10. Voices from the Classroom: Exceptional Teachers Speak.

    ERIC Educational Resources Information Center

    Maeroff, Gene I., Ed.

    The opinions and experiences reflected in this report are those of exceptional teachers chosen in a national competition, "Thanks to Teachers," sponsored by Apple Computer, Inc., the National Foundation for the Improvement of Education, the National Alliance of Business, and Group W Television. The report is divided into four sections: (1) the…

  11. 49 CFR 173.63 - Packaging exceptions.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... SHIPMENTS AND PACKAGINGS Definitions, Classification and Packaging for Class 1 § 173.63 Packaging exceptions...-shore supply vessel; (3) Cargo compartment of a cargo vessel; or (4) Passenger-carrying aircraft used to...) criteria for reclassification as limited quantity material for transportation by highway, rail or...

  12. 49 CFR 173.63 - Packaging exceptions.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... waste, marine pollutant, or is offered for transportation and transported byaircraft or vessel... SHIPMENTS AND PACKAGINGS Definitions, Classification and Packaging for Class 1 § 173.63 Packaging exceptions...-shore supply vessel; (3) Cargo compartment of a cargo vessel; or (4) Passenger-carrying aircraft used...

  13. 49 CFR 173.63 - Packaging exceptions.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... SHIPMENTS AND PACKAGINGS Definitions, Classification and Packaging for Class 1 § 173.63 Packaging exceptions...-shore supply vessel; (3) Cargo compartment of a cargo vessel; or (4) Passenger-carrying aircraft used to... hazardous substance, hazardous waste, marine pollutant, or is offered for transportation and transported...

  14. 49 CFR 173.63 - Packaging exceptions.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Transportation Other Regulations Relating to Transportation PIPELINE AND HAZARDOUS MATERIALS SAFETY... SHIPMENTS AND PACKAGINGS Definitions, Classification and Packaging for Class 1 § 173.63 Packaging exceptions...-shore supply vessel; (3) Cargo compartment of a cargo vessel; or (4) Passenger-carrying aircraft used...

  15. 48 CFR 1825.103 - Exceptions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... restrictions of the Buy American Act to Canadian end products with estimated values of $25,000 or less as... products on a parity with offers for domestic end products, except that applicable duty (whether or not a... products. (ii) The Assistant Administrator for Procurement has determined that for procurements subject...

  16. 48 CFR 225.7003-3 - Exceptions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... available high performance magnets that contain specialty metal, unless such high performance magnets are... specialty metals restrictions to magnets); and (D) COTS fasteners, unless— (1) The fasteners are... exception does not apply to high performance magnets containing specialty metals. See PGI...

  17. 48 CFR 225.7003-3 - Exceptions.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... available high performance magnets that contain specialty metal, unless such high performance magnets are... specialty metals restrictions to magnets); and (D) COTS fasteners, unless— (1) The fasteners are... exception does not apply to high performance magnets containing specialty metals. See PGI...

  18. 48 CFR 225.7003-3 - Exceptions.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... available high performance magnets that contain specialty metal, unless such high performance magnets are... specialty metals restrictions to magnets); and (D) COTS fasteners, unless— (1) The fasteners are... exception does not apply to high performance magnets containing specialty metals. See PGI...

  19. 48 CFR 225.7003-3 - Exceptions.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... performance magnets that contain specialty metal, unless such high performance magnets are incorporated into... restrictions to magnets); and (D) COTS fasteners, unless— (1) The fasteners are incorporated into COTS end... exception does not apply to high performance magnets containing specialty metals. See PGI...

  20. 48 CFR 225.7003-3 - Exceptions.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... available high performance magnets that contain specialty metal, unless such high performance magnets are... specialty metals restrictions to magnets); and (D) COTS fasteners, unless— (1) The fasteners are... exception does not apply to high performance magnets containing specialty metals. See PGI...

  1. 40 CFR 262.42 - Exception reporting.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ...) STANDARDS APPLICABLE TO GENERATORS OF HAZARDOUS WASTE Recordkeeping and Reporting § 262.42 Exception reporting. (a)(1) A generator of 1,000 kilograms or greater of hazardous waste in a calendar month, or... hazardous waste. (2) A generator of 1,000 kilograms or greater of hazardous waste in a calendar month, or...

  2. 40 CFR 262.42 - Exception reporting.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ...) STANDARDS APPLICABLE TO GENERATORS OF HAZARDOUS WASTE Recordkeeping and Reporting § 262.42 Exception reporting. (a)(1) A generator of 1,000 kilograms or greater of hazardous waste in a calendar month, or... hazardous waste. (2) A generator of 1,000 kilograms or greater of hazardous waste in a calendar month, or...

  3. 40 CFR 262.42 - Exception reporting.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ...) STANDARDS APPLICABLE TO GENERATORS OF HAZARDOUS WASTE Recordkeeping and Reporting § 262.42 Exception reporting. (a)(1) A generator of 1,000 kilograms or greater of hazardous waste in a calendar month, or... hazardous waste. (2) A generator of 1,000 kilograms or greater of hazardous waste in a calendar month, or...

  4. 40 CFR 262.42 - Exception reporting.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...) STANDARDS APPLICABLE TO GENERATORS OF HAZARDOUS WASTE Recordkeeping and Reporting § 262.42 Exception reporting. (a)(1) A generator of 1,000 kilograms or greater of hazardous waste in a calendar month, or... hazardous waste. (2) A generator of 1,000 kilograms or greater of hazardous waste in a calendar month, or...

  5. 40 CFR 262.42 - Exception reporting.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ...) STANDARDS APPLICABLE TO GENERATORS OF HAZARDOUS WASTE Recordkeeping and Reporting § 262.42 Exception reporting. (a)(1) A generator of 1,000 kilograms or greater of hazardous waste in a calendar month, or... hazardous waste. (2) A generator of 1,000 kilograms or greater of hazardous waste in a calendar month, or...

  6. Resource Directory: Migrant and Indian Exceptional Children.

    ERIC Educational Resources Information Center

    Indian Education Training, Inc., Albuquerque, NM.

    Designed as a supplementary resource for special education directors and teachers, this directory covers a five state area which includes Arizona, California, New Mexico, Texas, and Washington, and concentrates on targeted resources for Indian and migrant children with exceptional needs. After general discussions of services available for migrant…

  7. 2 CFR 200.102 - Exceptions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... promote cost-effectiveness in and across Federal programs. Proposals may draw on the innovative program... AND BUDGET GUIDANCE Reserved UNIFORM ADMINISTRATIVE REQUIREMENTS, COST PRINCIPLES, AND AUDIT... agency for indirect costs except where otherwise required by law or where OMB or other approval is...

  8. 40 CFR 1517.4 - Exceptions.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Protection of Environment COUNCIL ON ENVIRONMENTAL QUALITY PUBLIC MEETING PROCEDURES OF THE COUNCIL ON ENVIRONMENTAL QUALITY § 1517.4 Exceptions. (a) A meeting or portion thereof may be closed to public observation...) Disclose investigative techniques and procedures, or, (vi) Endanger the life or physical safety of law...

  9. 40 CFR 1517.4 - Exceptions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Protection of Environment COUNCIL ON ENVIRONMENTAL QUALITY PUBLIC MEETING PROCEDURES OF THE COUNCIL ON ENVIRONMENTAL QUALITY § 1517.4 Exceptions. (a) A meeting or portion thereof may be closed to public observation...) Disclose investigative techniques and procedures, or, (vi) Endanger the life or physical safety of law...

  10. 45 CFR 671.5 - Exceptions

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 45 Public Welfare 3 2013-10-01 2013-10-01 false Exceptions 671.5 Section 671.5 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL SCIENCE FOUNDATION WASTE REGULATION Prohibited... pollutants or waste allowed under the Act to Prevent Marine Pollution from Ships (33 U.S.C. 1901 et seq.), as...

  11. 45 CFR 671.5 - Exceptions

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 45 Public Welfare 3 2012-10-01 2012-10-01 false Exceptions 671.5 Section 671.5 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL SCIENCE FOUNDATION WASTE REGULATION Prohibited... pollutants or waste allowed under the Act to Prevent Marine Pollution from Ships (33 U.S.C. 1901 et seq.), as...

  12. 45 CFR 671.5 - Exceptions

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 3 2010-10-01 2010-10-01 false Exceptions 671.5 Section 671.5 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL SCIENCE FOUNDATION WASTE REGULATION Prohibited... pollutants or waste allowed under the Act to Prevent Marine Pollution from Ships (33 U.S.C. 1901 et seq.), as...

  13. 45 CFR 671.5 - Exceptions

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 45 Public Welfare 3 2014-10-01 2014-10-01 false Exceptions 671.5 Section 671.5 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL SCIENCE FOUNDATION WASTE REGULATION Prohibited... pollutants or waste allowed under the Act to Prevent Marine Pollution from Ships (33 U.S.C. 1901 et seq.), as...

  14. 45 CFR 671.5 - Exceptions

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 45 Public Welfare 3 2011-10-01 2011-10-01 false Exceptions 671.5 Section 671.5 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL SCIENCE FOUNDATION WASTE REGULATION Prohibited... pollutants or waste allowed under the Act to Prevent Marine Pollution from Ships (33 U.S.C. 1901 et seq.), as...

  15. Fort Lewis Exceptional Family Member Program (EFMP)

    ERIC Educational Resources Information Center

    Hebdon, Heather

    2007-01-01

    Located in the shadow of Mt. Rainier, Fort Lewis is the home of the highest per capita exceptional family member population in the Army. Ideally located on the Northwest coast of Washington State, Fort Lewis is home to the Strykers and First Brigade. Combined with its close proximity to McChord Air Force Base, the installation is ideally suited to…

  16. 48 CFR 725.403 - Exceptions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Section 725.403 Federal Acquisition Regulations System AGENCY FOR INTERNATIONAL DEVELOPMENT SOCIOECONOMIC PROGRAMS FOREIGN ACQUISITION Trade Agreements 725.403 Exceptions. FAR 25.4 establishes procedures for purchases under the Trade Agreements Act of 1979 (including GATT's Agreement on Government Procurement) and...

  17. 49 CFR 107.606 - Exceptions.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 2 2012-10-01 2012-10-01 false Exceptions. 107.606 Section 107.606 Transportation Other Regulations Relating to Transportation PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION HAZARDOUS MATERIALS AND OIL TRANSPORTATION HAZARDOUS MATERIALS...

  18. 49 CFR 107.606 - Exceptions.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 2 2013-10-01 2013-10-01 false Exceptions. 107.606 Section 107.606 Transportation Other Regulations Relating to Transportation PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION HAZARDOUS MATERIALS AND OIL TRANSPORTATION HAZARDOUS MATERIALS...

  19. EXCEPTIONAL CHILDREN IN A MODERN SOCIETY.

    ERIC Educational Resources Information Center

    LOVE, HAROLD D.

    INTENDED FOR UNDERGRADUATES AND BEGINNING GRADUATE STUDENTS, THE TEXT INTRODUCES THE KINDS OF EXCEPTIONALITY, INCIDENCE FIGURES, AND IDENTIFICATION PROCEDURES. THE FOLLOWING TOPICS ARE ALSO CONSIDERED--(1) THE MENTALLY RETARDED, (2) THE GIFTED, (3) THE BLIND AND PARTIALLY SIGHTED, (4) SPEECH PROBLEMS, (5) THE DEAF AND HARD OF HEARING, (6)…

  20. 40 CFR 761.217 - Exception reporting.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... PROHIBITIONS PCB Waste Disposal Records and Reports § 761.217 Exception reporting. (a)(1) A generator of PCB waste, who does not receive a copy of the manifest with the handwritten signature of the owner or operator of the designated facility within 35 days of the date the waste was accepted by the...

  1. FAPE Model of Exceptional Student Education Leadership

    ERIC Educational Resources Information Center

    Dubberly, Russell G.

    2012-01-01

    The FAPE Model of Exceptional Education Leadership is defined as facilitative, affiliative, praising and rewarding, and experiential and empirical. The FAPE administrator uses a facilitative approach that guides and coaches to help employees find a pathway to success. This leader works to build emotional capacity between all members of the…

  2. Conferencing and Compassion for an Exceptional Student

    ERIC Educational Resources Information Center

    Shafer, Gregory

    2011-01-01

    This essay is about the process of discovering and trying to help an exceptional student who was grappling with issues of real-life violence and incarceration and the desire to articulate their meaning to his life through writing. It describes how this student empowered himself to reflect on and deconstruct the meaning of his incarceration and how…

  3. 29 CFR 1905.28 - Exceptions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 29 Labor 5 2011-07-01 2011-07-01 false Exceptions. 1905.28 Section 1905.28 Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR RULES OF PRACTICE FOR VARIANCES, LIMITATIONS, VARIATIONS, TOLERANCES, AND EXEMPTIONS UNDER THE WILLIAMS-STEIGER...

  4. 7 CFR 4284.904 - Exception authority.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 15 2014-01-01 2014-01-01 false Exception authority. 4284.904 Section 4284.904 Agriculture Regulations of the Department of Agriculture (Continued) RURAL BUSINESS-COOPERATIVE SERVICE AND RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE GRANTS Value-Added Producer Grant Program...

  5. 7 CFR 4284.904 - Exception authority.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 15 2013-01-01 2013-01-01 false Exception authority. 4284.904 Section 4284.904 Agriculture Regulations of the Department of Agriculture (Continued) RURAL BUSINESS-COOPERATIVE SERVICE AND RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE GRANTS Value-Added Producer Grant Program...

  6. 7 CFR 4284.904 - Exception authority.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 15 2012-01-01 2012-01-01 false Exception authority. 4284.904 Section 4284.904 Agriculture Regulations of the Department of Agriculture (Continued) RURAL BUSINESS-COOPERATIVE SERVICE AND RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE GRANTS Value-Added Producer Grant Program...

  7. 14 CFR 93.133 - Exceptions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 2 2010-01-01 2010-01-01 false Exceptions. 93.133 Section 93.133 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIR TRAFFIC AND GENERAL OPERATING RULES SPECIAL AIR TRAFFIC RULES High Density Traffic Airports §...

  8. 27 CFR 555.182 - Exceptions.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 3 2011-04-01 2010-04-01 true Exceptions. 555.182 Section 555.182 Alcohol, Tobacco Products, and Firearms BUREAU OF ALCOHOL, TOBACCO, FIREARMS, AND EXPLOSIVES... or modified explosive materials; (2) Training in explosives detection or development or testing...

  9. 29 CFR 1905.28 - Exceptions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 5 2010-07-01 2010-07-01 false Exceptions. 1905.28 Section 1905.28 Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR RULES OF PRACTICE FOR VARIANCES, LIMITATIONS, VARIATIONS, TOLERANCES, AND EXEMPTIONS UNDER THE...

  10. Transition and Students with Twice Exceptionality

    ERIC Educational Resources Information Center

    Prior, Susan

    2013-01-01

    "Twice exceptional" is one of the terms used to describe students who have giftedness and a disability. This is a small heterogeneous population of individual learners who are underserved in special, gifted, and mainstream education settings. Despite the availability of research on transition for students with disabilities, there is…

  11. 36 CFR 1194.3 - General exceptions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... components. (f) Products located in spaces frequented only by service personnel for maintenance, repair, or... BOARD ELECTRONIC AND INFORMATION TECHNOLOGY ACCESSIBILITY STANDARDS General § 1194.3 General exceptions. (a) This part does not apply to any electronic and information technology operated by agencies, the...

  12. 48 CFR 39.204 - Exceptions.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... CONTRACTING ACQUISITION OF INFORMATION TECHNOLOGY Electronic and Information Technology 39.204 Exceptions. The... contractor incidental to a contract; (d) Is located in spaces frequented only by service personnel for... expense of compliance; and (ii) Agency resources available to its program or component for which the...

  13. 48 CFR 25.401 - Exceptions.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... military services overseas. X X X X (2) (i) Automatic data processing (ADP) telecommunications and transmission services (D304), except enhanced (i.e., value-added) telecommunications services. X X (ii) ADP... services (D399) X X (iii) Basic telecommunications network services (i.e., voice telephone services, packet...

  14. 48 CFR 225.701-70 - Exception.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 3 2014-10-01 2014-10-01 false Exception. 225.701-70 Section 225.701-70 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM... in military contingency, humanitarian, or peacekeeping operations in a country or region subject to...

  15. Cerebral Palsy: Exceptional Child Bibliography Series.

    ERIC Educational Resources Information Center

    Council for Exceptional Children, Reston, VA. Information Center on Exceptional Children.

    Eighty-one references selected from Exceptional Child Education Abstracts are included in the annotated bibliography on cerebral palsy, one in a series of over 50 similar listings dealing with handicapped and gifted children. For each listing, bibliographic and availability information, indexing and retrieval descriptors, and an abstract are…

  16. Architectural Considerations for Classrooms for Exceptional Children.

    ERIC Educational Resources Information Center

    Texas Education Agency, Austin.

    Definitions are provided of the following exceptionalities: blind, partially sighted, physically handicapped, minimally brain injured, deaf, educable mentally retarded (primary, junior, and senior high levels), trainable mentally retarded, speech handicapped, and emotionally disturbed. Architectural guidelines specify classroom location, size,…

  17. 19 CFR 10.41 - Instruments; exceptions.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... Traffic § 10.41 Instruments; exceptions. (a) Locomotives and other railroad equipment, trucks, buses... §§ 10.31, 10.183, or paragraph (d) of this section. (d) Any foreign-owned locomotive or other railroad... international cables under the high seas, if requiring storage in special tanks for preservation, may be placed...

  18. 14 CFR 1203.409 - Exceptional cases.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Exceptional cases. 1203.409 Section 1203.409 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION INFORMATION SECURITY PROGRAM... authority is normally the Installation Security Classification Officer. Persons other than NASA...

  19. Leiomyosarcoma of the Penis, an Exceptional Entity

    PubMed Central

    Romero Gonzalez, Edwin Javier; Marenco Jiménez, José L.; Mayorga Pineda, Maria P.; Martínez Morán, Alfonso; Castiñeiras Fernández, Jesús

    2015-01-01

    In tumors of the penis, mesenchymal tumors are extremely rare and within them, sarcomas are exceptional. We report a patient with a sarcomatous lesion treated with conservative surgery with good surgical outcome and the review of the literature, to present the latest advances in the treatment of this unusual entity. PMID:26793502

  20. 48 CFR 223.7304 - Exceptions.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Hexavalent Chromium 223.7304 Exceptions. The prohibition in 223.7303 does not apply to— (a) Legacy systems and their related parts, subsystems, and components that already contain hexavalent chromium. However, alternatives to hexavalent chromium shall be considered by the appropriate official during system...

  1. 48 CFR 223.7304 - Exceptions.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Hexavalent Chromium 223.7304 Exceptions. The prohibition in 223.7303 does not apply to— (a) Legacy systems and their related parts, subsystems, and components that already contain hexavalent chromium. However, alternatives to hexavalent chromium shall be considered by the appropriate official during system...

  2. 48 CFR 223.7304 - Exceptions.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Hexavalent Chromium 223.7304 Exceptions. The prohibition in 223.7303 does not apply to— (a) Legacy systems and their related parts, subsystems, and components that already contain hexavalent chromium. However, alternatives to hexavalent chromium shall be considered by the appropriate official during system...

  3. 48 CFR 223.7304 - Exceptions.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Hexavalent Chromium 223.7304 Exceptions. The prohibition in 223.7303 does not apply to— (a) Legacy systems and their related parts, subsystems, and components that already contain hexavalent chromium. However, alternatives to hexavalent chromium shall be considered by the appropriate official during system...

  4. 7 CFR 4284.684 - Exception authority.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 15 2010-01-01 2010-01-01 false Exception authority. 4284.684 Section 4284.684 Agriculture Regulations of the Department of Agriculture (Continued) RURAL BUSINESS-COOPERATIVE SERVICE AND RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE GRANTS Rural Business Opportunity Grants § 4284.684...

  5. 31 CFR 211.3 - Exceptions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... OF THE TREASURY FINANCIAL MANAGEMENT SERVICE DELIVERY OF CHECKS AND WARRANTS TO ADDRESSES OUTSIDE THE UNITED STATES, ITS TERRITORIES AND POSSESSIONS § 211.3 Exceptions. The regulations of this part do not... wages, or for goods or services purchased by the Government of the United States in foreign countries...

  6. A Priceless Playground for Exceptional Children.

    ERIC Educational Resources Information Center

    Adkins, Patricia G.

    Described are 20 pieces of therapeutic playground equipment constructed by volunteers and fathers of children in the Early Learning Center for Exceptional Children (El Paso, Texas). It is noted that discarded and readily available materials (such as old tires) were used, and that no commercial playground equipment was purchased. Information on the…

  7. 48 CFR 1505.202 - Exceptions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Exceptions. 1505.202 Section 1505.202 Federal Acquisition Regulations System ENVIRONMENTAL PROTECTION AGENCY ACQUISITION... in writing that the contract is for the services of experts for use in preparing or prosecuting a...

  8. 7 CFR 1427.1085 - Exceptions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Cotton Linters § 1427.1085 Exceptions. Notwithstanding any other provisions of this report: (a) The... necessary. (b) A warehouseman who has a net worth of at least $25,000 but who fails, or whose warehouse fails, to meet one or more of the other standards of this subpart may be approved if: (1) CCC determines...

  9. 7 CFR 1427.1085 - Exceptions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Cotton Linters § 1427.1085 Exceptions. Notwithstanding any other provisions of this report: (a) The... necessary. (b) A warehouseman who has a net worth of at least $25,000 but who fails, or whose warehouse fails, to meet one or more of the other standards of this subpart may be approved if: (1) CCC determines...

  10. 7 CFR 1956.99 - Exception authority.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 14 2010-01-01 2009-01-01 true Exception authority. 1956.99 Section 1956.99 Agriculture Regulations of the Department of Agriculture (Continued) RURAL HOUSING SERVICE, RURAL BUSINESS...) PROGRAM REGULATIONS (CONTINUED) DEBT SETTLEMENT Debt Settlement-Farm Loan Programs and...

  11. 40 CFR 761.215 - Exception reporting.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 761.215 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL... PROHIBITIONS PCB Waste Disposal Records and Reports § 761.215 Exception reporting. (a) A generator of PCB waste... the designated PCB commercial storage or disposal facility within 35 days of the date the waste...

  12. 40 CFR 761.217 - Exception reporting.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 761.217 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL... PROHIBITIONS PCB Waste Disposal Records and Reports § 761.217 Exception reporting. (a)(1) A generator of PCB waste, who does not receive a copy of the manifest with the handwritten signature of the owner...

  13. 40 CFR 761.215 - Exception reporting.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 761.215 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL... PROHIBITIONS PCB Waste Disposal Records and Reports § 761.215 Exception reporting. (a) A generator of PCB waste... the designated PCB commercial storage or disposal facility within 35 days of the date the waste...

  14. 40 CFR 761.215 - Exception reporting.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 761.215 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL... PROHIBITIONS PCB Waste Disposal Records and Reports § 761.215 Exception reporting. (a) A generator of PCB waste... the designated PCB commercial storage or disposal facility within 35 days of the date the waste...

  15. 7 CFR 1955.149 - Exception authority.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Agriculture Regulations of the Department of Agriculture (Continued) RURAL HOUSING SERVICE, RURAL BUSINESS...) PROGRAM REGULATIONS (CONTINUED) PROPERTY MANAGEMENT Disposal of Inventory Property General § 1955.149... exception is granted. (b) The Administrator may authorize withholding sale of surplus farm inventory...

  16. 10 CFR 2.701 - Exceptions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 1 2011-01-01 2011-01-01 false Exceptions. 2.701 Section 2.701 Energy NUCLEAR REGULATORY COMMISSION RULES OF PRACTICE FOR DOMESTIC LICENSING PROCEEDINGS AND ISSUANCE OF ORDERS Rules for Formal... conduct of military or foreign affairs functions. ...

  17. 10 CFR 2.701 - Exceptions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Exceptions. 2.701 Section 2.701 Energy NUCLEAR REGULATORY COMMISSION RULES OF PRACTICE FOR DOMESTIC LICENSING PROCEEDINGS AND ISSUANCE OF ORDERS Rules for Formal... conduct of military or foreign affairs functions. ...

  18. How To Be an Exceptional Follower.

    ERIC Educational Resources Information Center

    Sevier, Robert A.

    1999-01-01

    Argues that college trustees and administrators must move beyond their image as docile and weak followers, and learn how to follow the leader they have chosen. Five follower types are identified, focusing on the characteristics and responsibilities of "exceptional" followers, who work closely with the leader and actively participate in decision…

  19. 48 CFR 8.706 - Purchase exceptions.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Purchase exceptions. 8.706 Section 8.706 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION ACQUISITION PLANNING REQUIRED SOURCES OF SUPPLIES AND SERVICES Acquisition From Nonprofit Agencies Employing People Who Are...

  20. Fort Lewis Exceptional Family Member Program (EFMP)

    ERIC Educational Resources Information Center

    Hebdon, Heather

    2007-01-01

    Located in the shadow of Mt. Rainier, Fort Lewis is the home of the highest per capita exceptional family member population in the Army. Ideally located on the Northwest coast of Washington State, Fort Lewis is home to the Strykers and First Brigade. Combined with its close proximity to McChord Air Force Base, the installation is ideally suited to…

  1. 48 CFR 23.104 - Exceptions.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Exceptions. 23.104 Section 23.104 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION SOCIOECONOMIC PROGRAMS ENVIRONMENT, ENERGY AND WATER EFFICIENCY, RENEWABLE ENERGY TECHNOLOGIES, OCCUPATIONAL SAFETY, AND...

  2. 48 CFR 23.104 - Exceptions.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 1 2012-10-01 2012-10-01 false Exceptions. 23.104 Section 23.104 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION SOCIOECONOMIC PROGRAMS ENVIRONMENT, ENERGY AND WATER EFFICIENCY, RENEWABLE ENERGY TECHNOLOGIES, OCCUPATIONAL SAFETY, AND...

  3. 48 CFR 23.104 - Exceptions.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 1 2014-10-01 2014-10-01 false Exceptions. 23.104 Section 23.104 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION SOCIOECONOMIC PROGRAMS ENVIRONMENT, ENERGY AND WATER EFFICIENCY, RENEWABLE ENERGY TECHNOLOGIES, OCCUPATIONAL SAFETY, AND...

  4. 48 CFR 23.104 - Exceptions.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 1 2013-10-01 2013-10-01 false Exceptions. 23.104 Section 23.104 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION SOCIOECONOMIC PROGRAMS ENVIRONMENT, ENERGY AND WATER EFFICIENCY, RENEWABLE ENERGY TECHNOLOGIES, OCCUPATIONAL SAFETY, AND...

  5. 7 CFR 4287.303 - Exception authority.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 15 2013-01-01 2013-01-01 false Exception authority. 4287.303 Section 4287.303 Agriculture Regulations of the Department of Agriculture (Continued) RURAL BUSINESS-COOPERATIVE SERVICE AND RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE SERVICING Servicing Biorefinery Assistance Guaranteed...

  6. 7 CFR 4287.303 - Exception authority.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 15 2014-01-01 2014-01-01 false Exception authority. 4287.303 Section 4287.303 Agriculture Regulations of the Department of Agriculture (Continued) RURAL BUSINESS-COOPERATIVE SERVICE AND RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE SERVICING Servicing Biorefinery Assistance Guaranteed...

  7. 7 CFR 4287.303 - Exception authority.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 15 2012-01-01 2012-01-01 false Exception authority. 4287.303 Section 4287.303 Agriculture Regulations of the Department of Agriculture (Continued) RURAL BUSINESS-COOPERATIVE SERVICE AND RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE SERVICING Servicing Biorefinery Assistance Guaranteed...

  8. 48 CFR 225.7603 - Exceptions.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 3 2014-10-01 2014-10-01 false Exceptions. 225.7603 Section 225.7603 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE SOCIOECONOMIC PROGRAMS FOREIGN ACQUISITION Secondary Arab Boycott of Israel...

  9. 48 CFR 225.7603 - Exceptions.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 3 2012-10-01 2012-10-01 false Exceptions. 225.7603 Section 225.7603 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE SOCIOECONOMIC PROGRAMS FOREIGN ACQUISITION Secondary Arab Boycott of Israel...

  10. 48 CFR 225.7603 - Exceptions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Exceptions. 225.7603 Section 225.7603 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE SOCIOECONOMIC PROGRAMS FOREIGN ACQUISITION Secondary Arab Boycott of Israel...

  11. 48 CFR 225.7603 - Exceptions.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 3 2011-10-01 2011-10-01 false Exceptions. 225.7603 Section 225.7603 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE SOCIOECONOMIC PROGRAMS FOREIGN ACQUISITION Secondary Arab Boycott of Israel...

  12. 48 CFR 225.7603 - Exceptions.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 3 2013-10-01 2013-10-01 false Exceptions. 225.7603 Section 225.7603 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE SOCIOECONOMIC PROGRAMS FOREIGN ACQUISITION Secondary Arab Boycott of Israel...

  13. 21 CFR 1316.66 - Exceptions.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... PROCEDURES Administrative Hearings § 1316.66 Exceptions. (a) Within twenty days after the date upon which a... Administrative Law Judge may, upon the request of any party to a proceeding, grant time beyond the twenty days... party if he determines that no party in the hearing will be unduly prejudiced and that the ends of...

  14. 42 CFR 423.578 - Exceptions process.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ...) MEDICARE PROGRAM (CONTINUED) VOLUNTARY MEDICARE PRESCRIPTION DRUG BENEFIT Grievances, Coverage... to a plan's tiered cost-sharing structure. Each Part D plan sponsor that provides prescription drug... category as the requested prescription drug that is the subject of the exceptions request. (3) An...

  15. 42 CFR 423.578 - Exceptions process.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ...) MEDICARE PROGRAM (CONTINUED) VOLUNTARY MEDICARE PRESCRIPTION DRUG BENEFIT Grievances, Coverage... to a plan's tiered cost-sharing structure. Each Part D plan sponsor that provides prescription drug... category as the requested prescription drug that is the subject of the exceptions request. (3) An...

  16. 48 CFR 5.202 - Exceptions.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... solicited. This exception does not apply to proposed contract actions covered by the World Trade Organization Government Procurement Agreement or a Free Trade Agreement (see Subpart 25.4); (13) The proposed... organizations, has the effect of requiring that the acquisition shall be from specified sources; (4)...

  17. 48 CFR 5.202 - Exceptions.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... solicited. This exception does not apply to proposed contract actions covered by the World Trade Organization Government Procurement Agreement or a Free Trade Agreement (see Subpart 25.4); (13) The proposed... organizations, has the effect of requiring that the acquisition shall be from specified sources; (4)...

  18. 48 CFR 5.202 - Exceptions.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... solicited. This exception does not apply to proposed contract actions covered by the World Trade Organization Government Procurement Agreement or a Free Trade Agreement (see Subpart 25.4); (13) The proposed... organizations, has the effect of requiring that the acquisition shall be from specified sources; (4)...

  19. 7 CFR 4288.107 - Exception authority.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 15 2012-01-01 2012-01-01 false Exception authority. 4288.107 Section 4288.107 Agriculture Regulations of the Department of Agriculture (Continued) RURAL BUSINESS-COOPERATIVE SERVICE AND RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE PAYMENT PROGRAMS Advanced Biofuel Payment Program...

  20. 7 CFR 4288.107 - Exception authority.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 15 2013-01-01 2013-01-01 false Exception authority. 4288.107 Section 4288.107 Agriculture Regulations of the Department of Agriculture (Continued) RURAL BUSINESS-COOPERATIVE SERVICE AND RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE PAYMENT PROGRAMS Advanced Biofuel Payment Program...