Comparison of injection drug users accessing syringes from pharmacies, syringe exchange programs, and other syringe sources to inform targeted HIV prevention and intervention strategies

PubMed Central

Rudolph, Abby E.; Crawford, Natalie D.; Ompad, Danielle C.; Benjamin, Ebele O.; Stern, Rachel J.; Fuller, Crystal M.

2011-01-01

Objective In New York, syringe exchange programs (SEPs) and pharmacies provide syringe access for IDUs but may be unable to meet the needs of all IDUs. This analysis aims to describe IDUs who access syringes through different outlets to help inform the prevention needs of IDUs who under-utilize safe syringe sources in a city where syringe availability is high relative to other U.S. cities. Design Cross-sectional study Setting New York City (2005–2007) Participants 285 IDUs recruited using street-intercept sampling Intervention(s) Not Applicable Main outcome measure(s) IDUs using SEPs, pharmacies, or other outlets as a primary syringe source were compared by sociodemographic characteristics, injection practices and medical service utilization. Results Chi-square tests and polytomous logistic regression were used to compare IDUs with different self-reported primary syringe sources used 6 months prior to study entry. Compared with IDUs using other syringe sources, those using primarily SEPs were less likely to be Black (AOR:0.26 95%CI:0.11–0.57), more likely to inject daily (AOR:3.32; 95%CI:1.58–6.98), and more likely to inject with a new syringe (AOR:2.68; 95%CI:1.30–5.54). Compared with IDUs using other syringe sources, those using primarily pharmacies were less likely to be Black (AOR:0.39; 95%CI0.17–0.90). Conclusion These data suggest that pharmacies and SEPs may be reaching different populations of IDUs and highlight a sub-population of highly marginalized IDUs (Black and infrequent injectors) who are under-utilizing safe syringe sources in New York City. Targeted interventions are needed to reduce racial disparities and increase utilization of safe syringe outlets. PMID:20199954

Racial differences in acquisition of syringes from pharmacies under conditions of legal but restricted sales.

PubMed

Costenbader, Elizabeth C; Zule, William A; Coomes, Curtis C

2010-09-01

Injecting drug users (IDUs) are at increased risk of acquiring and transmitting HIV and other bloodborne pathogens through the multi-person use of syringes. Although research has shown that increased access to syringes through syringe exchange programs (SEPs) is an effective strategy to reduce risky injection practices many areas of the United States still do not have SEPs. In the absence of SEPs, legislation allowing pharmacies over-the-counter sales of syringes has also been shown to reduce syringe sharing. The success of pharmacy sales however is limited by other legal stipulations, such as drug paraphernalia laws, which in turn may contribute to fear among IDUs about being caught purchasing and carrying syringes. Between 2003 and 2006, 851 out-of-treatment IDUs were recruited using street outreach in the Raleigh-Durham (North Carolina) area. Data were collected using audio-computer assisted interview (ACASI) technology. Multiple logistic regression analyses were performed to assess factors associated with purchasing syringes from pharmacies. In our study sample, African-American IDUs were one-fifth as likely as white IDUs to report pharmacies as their primary source of syringes. Given the absence of syringe exchange programs and the relatively high prevalence of HCV and HIV among IDUs in the Raleigh-Durham area, the limited use of pharmacies as a source of syringes among African-American IDUs in this study sample is problematic. The study findings support the need for effective multilevel interventions to increase access to clean needles in this population, as well as for policy interventions, such as legalization of SEPs and elimination of penalties for carrying syringes, to reduce harm and eliminate the health threats posed by receptive syringe sharing. Copyright 2010 Elsevier B.V. All rights reserved.

Overexpression of SepJ alters septal morphology and heterocyst pattern regulated by diffusible signals in Anabaena.

PubMed

Mariscal, Vicente; Nürnberg, Dennis J; Herrero, Antonia; Mullineaux, Conrad W; Flores, Enrique

2016-09-01

Filamentous, N2 -fixing, heterocyst-forming cyanobacteria grow as chains of cells that are connected by septal junctions. In the model organism Anabaena sp. strain PCC 7120, the septal protein SepJ is required for filament integrity, normal intercellular molecular exchange, heterocyst differentiation, and diazotrophic growth. An Anabaena strain overexpressing SepJ made wider septa between vegetative cells than the wild type, which correlated with a more spread location of SepJ in the septa as observed with a SepJ-GFP fusion, and contained an increased number of nanopores, the septal peptidoglycan perforations that likely accommodate septal junctions. The septa between heterocysts and vegetative cells, which are narrow in wild-type Anabaena, were notably enlarged in the SepJ-overexpressing mutant. Intercellular molecular exchange tested with fluorescent tracers was increased for the SepJ-overexpressing strain specifically in the case of calcein transfer between vegetative cells and heterocysts. These results support an association between calcein transfer, SepJ-related septal junctions, and septal peptidoglycan nanopores. Under nitrogen deprivation, the SepJ-overexpressing strain produced an increased number of contiguous heterocysts but a decreased percentage of total heterocysts. These effects were lost or altered in patS and hetN mutant backgrounds, supporting a role of SepJ in the intercellular transfer of regulatory signals for heterocyst differentiation. © 2016 John Wiley & Sons Ltd.

Translations on Telecommunications Policy, Research and Development, Number 26.

DTIC Science & Technology

1978-01-06

Revolution, residents of Yerevan and the Ararat Valley received the oppor- tunity to watch Central Television’s fourth program being retransmitted on...EXCHANGE IN THE PROTEO SYSTEM Milan TELECOMUNICAZIONI in Italian Nos 60-61 Sep-Dec 76 PP 21-34 [Article by Guido Arrigoni, Sergio Dal Monte and...Programs of a Spe- cial Processor," 12th Design Automation Conference, Boston, June 1975. 8. Arrigoni, G., Di Stefano, G.B., Dal Monte , S., Magnolfi

The Sep1 Mutant of Saccharomyces Cerevisiae Arrests in Pachytene and Is Deficient in Meiotic Recombination

PubMed Central

Tishkoff, D. X.; Rockmill, B.; Roeder, G. S.; Kolodner, R. D.

1995-01-01

Strand exchange protein 1 (Sep1) from Saccharomyces cerevisiae promotes homologous pairing of DNA in vitro and sep1 mutants display pleiotropic phenotypes in both vegetative and meiotic cells. In this study, we examined in detail the ability of the sep1 mutant to progress through meiosis I prophase and to undergo meiotic recombination. In meiotic return-to-growth experiments, commitment to meiotic recombination began at the same time in wild type and mutant; however, recombinants accumulated at decreased rates in the mutant. Gene conversion eventually reached nearly wild-type levels, whereas crossing over reached 15-50% of wild type. In an assay of intrachromosomal pop-out recombination, the sep1, dmc1 and rad51 single mutations had only small effects; however, pop-out recombination was virtually eliminated in the sep1 dmc1 and sep1 rad51 double mutants, providing evidence for multiple recombination pathways. Analysis of meiotic recombination intermediates indicates that the sep1 mutant is deficient in meiotic double-strand break repair. In a physical assay, the formation of mature reciprocal recombinants in the sep1 mutant was delayed relative to wild type and ultimately reached only 50% of the wild-type level. Electron microscopic analysis of meiotic nuclear spreads indicates that the sep1δ mutant arrests in pachytene, with apparently normal synaptonemal complex. This arrest is RAD9-independent. We hypothesize that the Sep1 protein participates directly in meiotic recombination and that other strand exchange enzymes, acting in parallel recombination pathways, are able to substitute partially for the absence of the Sep1 protein. PMID:7713413

An observation of lower rates of drug use over time in community syringe exchangers.

PubMed

Kidorf, Michael; King, Van L; Peirce, Jessica; Kolodner, Ken; Brooner, Robert K

2013-01-01

The present study evaluated changes in rates of self-reported heroin and cocaine use in opioid-dependent individuals newly registered to a syringe exchange program (SEP), and examined the effects of recovery-oriented longitudinal variables (i.e., substance abuse treatment, self-help group participation, employment) on changes in drug use. Study participants (n = 240) were opioid-dependent and drawn from a larger study evaluating strategies to improve treatment-seeking. Mixed model analyses were used to evaluate changes in rates of heroin and cocaine use, and longitudinal correlates of change in these substances, over a one-year period. Results showed reductions in days of heroin and cocaine use over time, and that participation in recovery-oriented activities was strongly associated with greater changes in drug use. These results suggest SEPs can play a vital role in facilitating reductions in drug use through motivating participation in treatment and other recovery-oriented activities. Copyright © American Academy of Addiction Psychiatry.

Awareness of pre-exposure prophylaxis (PrEP) among women who inject drugs in NYC: the importance of networks and syringe exchange programs for HIV prevention.

PubMed

Walters, Suzan M; Reilly, Kathleen H; Neaigus, Alan; Braunstein, Sarah

2017-06-29

Women who inject drugs (WWID) are at heightened risk for HIV due to biological, behavioral, and structural factors. Pre-exposure prophylaxis (PrEP) could aid in HIV prevention for WWID. However, little is known about WWID awareness of PrEP, which is a necessary step that must occur before PrEP uptake. We report factors associated with greater awareness among WWID to identify efficient means of awareness dissemination. Data from the 2015 National HIV Behavioral Surveillance (NHBS) system cycle on injection drug use collected in New York City (NYC) were used. Bivariable analyses, using chi-squared statistics, were conducted to examine correlates of awareness of PrEP with socio-demographic, behavioral, and health care variables. Multivariable logistic regression was used to estimate adjusted associations and determine differences in awareness of PrEP. The analysis consisted of 118 WWID. Awareness of PrEP was relatively low (31%), and risk factors were high. In the last 12 months, almost two thirds (65%) reported condomless sex, approximately one third (31%) reported transactional sex, and one third (32%) reported sharing injection equipment. In multivariable logistic regression, increased PrEP awareness was associated with reported transactional sex (AOR 3.32, 95% CI 1.22-9.00) and having a conversation about HIV prevention at a syringe exchange program (SEP) (AOR 7.61, 95% CI 2.65-21.84). We did not find race, education, household income, age, binge drinking, or sexual identity to be significantly associated with PrEP awareness. Large proportions of WWID were unaware of PrEP. These findings suggest that social networks (specifically sex work and SEP networks) are an efficient means for disseminating messaging about prevention materials such as PrEP. We recommend that SEP access increase, SEP processes be adopted in other health care settings, and WWID networks be utilized to increase PrEP awareness.

Development of an Enhanced Payback Function for the Superior Energy Performance Program

DOE Office of Scientific and Technical Information (OSTI.GOV)

Therkelsen, Peter; Rao, Prakash; McKane, Aimee

2015-08-03

The U.S. DOE Superior Energy Performance (SEP) program provides recognition to industrial and commercial facilities that achieve certification to the ISO 50001 energy management system standard and third party verification of energy performance improvements. Over 50 industrial facilities are participating and 28 facilities have been certified in the SEP program. These facilities find value in the robust, data driven energy performance improvement result that the SEP program delivers. Previous analysis of SEP certified facility data demonstrated the cost effectiveness of SEP and identified internal staff time to be the largest cost component related to SEP implementation and certification. This papermore » analyzes previously reported and newly collected data of costs and benefits associated with the implementation of an ISO 50001 and SEP certification. By disaggregating “sunk energy management system (EnMS) labor costs”, this analysis results in a more accurate and detailed understanding of the costs and benefits of SEP participation. SEP is shown to significantly improve and sustain energy performance and energy cost savings, resulting in a highly attractive return on investment. To illustrate these results, a payback function has been developed and is presented. On average facilities with annual energy spend greater than $2M can expect to implement SEP with a payback of less than 1.5 years. Finally, this paper also observes and details decreasing facility costs associated with implementing ISO 50001 and certifying to the SEP program, as the program has improved from pilot, to demonstration, to full launch.« less

Functional Dependence between Septal Protein SepJ from Anabaena sp. Strain PCC 7120 and an Amino Acid ABC-Type Uptake Transporter.

PubMed

Escudero, Leticia; Mariscal, Vicente; Flores, Enrique

2015-08-01

In the diazotrophic filaments of heterocyst-forming cyanobacteria, two different cell types, the CO2-fixing vegetative cells and the N2-fixing heterocysts, exchange nutrients, including some amino acids. In the model organism Anabaena sp. strain PCC 7120, the SepJ protein, composed of periplasmic and integral membrane (permease) sections, is located at the intercellular septa joining adjacent cells in the filament. The unicellular cyanobacterium Synechococcus elongatus strain PCC 7942 bears a gene, Synpcc7942_1024 (here designated dmeA), encoding a permease homologous to the SepJ permease domain. Synechococcus strains lacking dmeA or lacking dmeA and expressing Anabaena sepJ were constructed. The Synechococcus dmeA mutant showed a significant 22 to 32% decrease in the uptake of aspartate, glutamate, and glutamine, a phenotype that could be partially complemented by Anabaena sepJ. Synechococcus mutants of an ATP-binding-cassette (ABC)-type transporter for polar amino acids showed >98% decreased uptake of glutamate irrespective of the presence of dmeA or Anabaena sepJ in the same strain. Thus, Synechococcus DmeA or Anabaena SepJ is needed to observe full (or close to full) activity of the ABC transporter. An Anabaena sepJ deletion mutant was significantly impaired in glutamate and aspartate uptake, which also in this cyanobacterium requires the activity of an ABC-type transporter for polar amino acids. SepJ appears therefore to generally stimulate the activity of cyanobacterial ABC-type transporters for polar amino acids. Conversely, an Anabaena mutant of three ABC-type transporters for amino acids was impaired in the intercellular transfer of 5-carboxyfluorescein, a SepJ-related property. Our results unravel possible functional interactions in transport elements important for diazotrophic growth. Membrane transporters are essential for many aspects of cellular life, from uptake and export of substances in unicellular organisms to intercellular molecular exchange in multicellular organisms. Heterocyst-forming cyanobacteria such as Anabaena represent a unique case of multicellularity, in which two cell types exchange nutrients and regulators. The SepJ protein located at the intercellular septa in the filaments of Anabaena contains a permease domain of the drug/metabolite transporter (DMT) superfamily that somehow contributes to intercellular molecular transfer. In this work, we have found that SepJ stimulates the activity of a polar amino acid uptake transporter of the ATP-binding-cassette (ABC) superfamily, which could itself affect an intercellular transfer activity related to SepJ, thus unraveling possible functional interactions between these different transporters. Copyright © 2015, American Society for Microbiology. All Rights Reserved.

Program manual for the Shuttle Electric Power System analysis computer program (SEPS), volume 1 of program documentation

NASA Technical Reports Server (NTRS)

Bains, R. W.; Herwig, H. A.; Luedeman, J. K.; Torina, E. M.

1974-01-01

The Shuttle Electric Power System (SEPS) computer program is considered in terms of the program manual, programmer guide, and program utilization. The main objective is to provide the information necessary to interpret and use the routines comprising the SEPS program. Subroutine descriptions including the name, purpose, method, variable definitions, and logic flow are presented.

Additional application of the NASCAP code. Volume 2: SEPS, ion thruster neutralization and electrostatic antenna model

NASA Technical Reports Server (NTRS)

Katz, I.; Cassidy, J. J.; Mandell, M. J.; Parks, D. E.; Schnuelle, G. W.; Stannard, P. R.; Steen, P. G.

1981-01-01

The interactions of spacecraft systems with the surrounding plasma environment were studied analytically for three cases of current interest: calculating the impact of spacecraft generated plasmas on the main power system of a baseline solar electric propulsion stage (SEPS), modeling the physics of the neutralization of an ion thruster beam by a plasma bridge, and examining the physical and electrical effects of orbital ambient plasmas on the operation of an electrostatically controlled membrane mirror. In order to perform these studies, the NASA charging analyzer program (NASCAP) was used as well as several other computer models and analytical estimates. The main result of the SEPS study was to show how charge exchange ion expansion can create a conducting channel between the thrusters and the solar arrays. A fluid-like model was able to predict plasma potentials and temperatures measured near the main beam of an ion thruster and in the vicinity of a hollow cathode neutralizer. Power losses due to plasma currents were shown to be substantial for several proposed electrostatic antenna designs.

Higher Education Support Services and Graduation Rates of Structured Education Program Students

ERIC Educational Resources Information Center

Hepner, Seth

2017-01-01

The 1st-year retention rate of the Structured Education Program (SEP) is 90%, yet the 6-year graduation rate of SEP students is 29%. The gap between SEP 1st-year retention and graduation rates is the problem that this study addressed. The low graduation rate of SEP students is an important issue because graduation rates are used to measure the…

Great SEP events and space weather: 2. Automatic determination of the solar energetic particle spectrum

NASA Astrophysics Data System (ADS)

Applbaum, David; Dorman, Lev; Pustil'Nik, Lev; Sternlieb, Abraham; Zagnetko, Alexander; Zukerman, Igor

In Applbaum et al. (2010) it was described how the "SEP-Search" program works automat-ically, determining on the basis of on-line one-minute NM data the beginning of a great SEP event. The "SEP-Search" next uses one-minute data in order to check whether or not the observed increase reflects the beginning of a real great SEP event. If yes, the program "SEP-Research/Spectrum" automatically starts to work on line. We consider two variants: 1) quiet period (no change in cut-off rigidity), 2) disturbed period (characterized with possible changing of cut-off rigidity). We describe the method of determining the spectrum of SEP in the 1st vari-ant (for this we need data for at least two components with different coupling functions). For the 2nd variant we need data for at least three components with different coupling functions. We show that for these purposes one can use data of the total intensity and some different mul-tiplicities, but that it is better to use data from two or three NM with different cut-off rigidities. We describe in detail the algorithms of the program "SEP-Research/Spectrum." We show how this program worked on examples of some historical great SEP events. The work of NM on Mt. Hermon is supported by Israel (Tel Aviv University and ISA) -Italian (UNIRoma-Tre and IFSI-CNR) collaboration.

Alternative Fuels Data Center

Science.gov Websites

State Energy Program (SEP) Funding The SEP provides grants to states to assist in designing receives SEP funding and manages all SEP-funded projects. States may also receive project funding from ) for SEP Special Projects. EERE distributes the funding through an annual competitive solicitation to

Chain exchange in triblock copolymer micelles

NASA Astrophysics Data System (ADS)

Lu, Jie; Lodge, Timothy; Bates, Frank

2015-03-01

Block polymer micelles offer a host of technological applications including drug delivery, viscosity modification, toughening of plastics, and colloidal stabilization. Molecular exchange between micelles directly influences the stability, structure and access to an equilibrium state in such systems and this property recently has been shown to be extraordinarily sensitive to the core block molecular weight in diblock copolymers. The dependence of micelle chain exchange dynamics on molecular architecture has not been reported. The present work conclusively addresses this issue using time-resolved small-angle neutron scattering (TR-SANS) applied to complimentary S-EP-S and EP-S-EP triblock copolymers dissolved in squalane, a selective solvent for the EP blocks, where S and EP refer to poly(styrene) and poly(ethylenepropylene), respectively. Following the overall SANS intensity as a function of time from judiciously deuterium labelled polymer and solvent mixtures directly probes the rate of molecular exchange. Remarkably, the two triblocks display exchange rates that differ by approximately ten orders of magnitude, even though the solvophobic S blocks are of comparable size. This discovery is considered in the context of a model that successfully explains S-EP diblock exchange dynamics.

Access to Sterile Syringes through San Francisco Pharmacies and the Association with HIV Risk Behavior among Injection Drug Users

PubMed Central

Kral, Alex H.; Stopka, Thomas J.; Garfein, Richard S.; Reuckhaus, Paul; Bluthenthal, Ricky N.

2010-01-01

Increased options for syringe acquisition and disposal have been associated with reductions in high-risk behaviors. This study determined the extent of pharmacy uptake in accessing syringes among injection drug users (IDUs) and estimated associations between pharmacy uptake and safer injection/disposal practices. Two years after the implementation of California’s Disease Prevention Demonstration Project, which removed restrictions to non-prescription syringe sales through pharmacies with local authorization, IDUs were recruited through street outreach in San Francisco and interviewed regarding recent syringe acquisition, use, and disposal. The sample of 105 persons included a high proportion of men (67%), people of color (49%), and homeless persons (71%). The most common syringe source was a syringe exchange program (SEP) (80%), with pharmacies being accessed by 39% of respondents. The most commonly cited source of disposal was a SEP (65%), with very few reports of pharmacy disposal (2%). Adjusted analysis showed that unsuccessful attempts to purchase syringes at a pharmacy increased the odds of both injecting with a used syringe and giving away a used syringe. Using a SEP decreased the odds of unsafe injection and disposal practices. Thus, 2 years after the initiation of the California Disease Prevention Demonstration Project, results from this small study suggest that SEPs still provide the majority of syringe distribution and disposal services to San Francisco IDUs; however, pharmacies now augment syringe access. In addition, unsafe injection behavior is reported more often among those who do not use these syringe sources. These results are consistent with prior studies in suggesting that increasing the availability of syringes through SEPs and pharmacies, and developing bridges between them, may further reduce syringe-related risk. PMID:20526690

The Business Value of Superior Energy Performance

DOE Office of Scientific and Technical Information (OSTI.GOV)

McKane, Aimee; Scheihing, Paul; Evans, Tracy

Industrial facilities participating in the U.S. Department of Energy’s (US DOE) Superior Energy Performance (SEP) program are finding that it provides them with significant business value. This value starts with the implementation of ISO 50001-Energy management system standard, which provides an internationally-relevant framework for integration of energy management into an organization’s business processes. The resulting structure emphasizes effective use of available data and supports continual improvement of energy performance. International relevance is particularly important for companies with a global presence or trading interests, providing them with access to supporting ISO standards and a growing body of certified companies representing themore » collective knowledge of communities of practice. This paper examines the business value of SEP, a voluntary program that builds on ISO 50001, inviting industry to demonstrate an even greater commitment through third-party verification of energy performance improvement to a specified level of achievement. Information from 28 facilities that have already achieved SEP certification will illustrate key findings concerning both the value and the challenges from SEP/ISO 50001 implementation. These include the facilities’ experience with implementation, internal and external value of third-party verification of energy performance improvement; attractive payback periods and the importance of SEP tools and guidance. US DOE is working to bring the program to scale, including the Enterprise-Wide Accelerator (SEP for multiple facilities in a company), the Ratepayer-Funded Program Accelerator (supporting tools for utilities and program administrators to include SEP in their program offerings), and expansion of the program to other sectors and industry supply chains.« less

Comparison of three sequential extraction procedures for arsenic fractionation in highly polluted sites.

PubMed

Wan, Xiang; Dong, Haochen; Feng, Liu; Lin, Zhijia; Luo, Qiuchen

2017-07-01

Three sequential extraction procedures (SEPs) including Tessier, Rauret, and Shiowatana SEPs, were compared for arsenic fractionation using highly polluted soils. In the definition context of exchangeable, reducible, oxidizable and residual fractions, with similar arsenic recovery and reproducibility, Tessier and Rauret SEPs were comparable to each other, whereas Shiowatana SEP showed higher extraction efficiency in all the first three arsenic fractions, although it might overestimate the reducible arsenic. Pot experiment indicated three SEPs all could provide an estimation of the most bioavailable arsenic fraction, and the application of Shiowatana SEP should be preferred. Accordingly, a case study with Shiowatana SEP for a site near a realgar mine area is conducted. The results show that although arsenic in this area presents predominantly in the stable fractions, the sum of most bioavailable fractions was accounted around 11% of total arsenic, and moreover, about another 10% of the total arsenic, the fourth fraction in Shiowatana SEP is likely to be transferred into bioavailable species under suitable conditions, such as strong acid impact, revealing a real major risk source being formed. The study indicated that Shiowatana should be more suitable for arsenic fractionation to provide valuable information in the framework of risk assessment. Copyright © 2017 Elsevier Ltd. All rights reserved.

User's manual for the Shuttle Electric Power System analysis computer program (SEPS), volume 2 of program documentation

NASA Technical Reports Server (NTRS)

Bains, R. W.; Herwig, H. A.; Luedeman, J. K.; Torina, E. M.

1974-01-01

The Shuttle Electric Power System Analysis SEPS computer program which performs detailed load analysis including predicting energy demands and consumables requirements of the shuttle electric power system along with parameteric and special case studies on the shuttle electric power system is described. The functional flow diagram of the SEPS program is presented along with data base requirements and formats, procedure and activity definitions, and mission timeline input formats. Distribution circuit input and fixed data requirements are included. Run procedures and deck setups are described.

Syringe Access, Syringe Sharing, and Police Encounters among People Who Inject Drugs in New York City: A Community-Level Perspective

PubMed Central

Beletsky, Leo; Heller, Daliah; Jenness, Samuel M.; Neaigus, Alan; Gelpi-Acosta, Camila; Hagan, Holly

2013-01-01

Background Injection drug user (IDU) experience and perceptions of police practices may alter syringe exchange program (SEP) use or influence risky behaviour. Previously, no community-level data had been collected to identify the prevalence or correlates of police encounters reported by IDUs in the United States. Methods New York City IDUs recruited through respondent-driven sampling were asked about past-year police encounters and risk behaviours, as part of the National HIV Behavioural Surveillance study. Data were analysed using multiple logistic regression. Results A majority (52%) of respondents (n=514) reported being stopped by police officers; 10% reported syringe confiscation. In multivariate modelling, IDUs reporting police stops were less likely to use SEPs consistently (adjusted odds ratio [AOR]=0.59; 95% confidence interval [CI]=0.40–0.89), and IDUs who had syringes confiscated may have been more likely to share syringes (AOR=1.76; 95% CI=0.90–3.44), though the finding did not reach statistical significance. Conclusions Findings suggest that police encounters may influence consistent SEP use. The frequency of IDU-police encounters highlights the importance of including contextual and structural measures in infectious disease risk surveillance, and the need to develop approaches harmonizing structural policing and public health. PMID:23916801

Correlates of syringe coverage for heroin injection in 35 large metropolitan areas in the US in which heroin is the dominant injected drug

PubMed Central

Tempalski, Barbara; Cooper, Hannah L.; Friedman, Samuel R.; Des Jarlais, Don C.; Brady, Joanne; Gostnell, Karla

2009-01-01

Background Scientific consensus holds that if, at the outset of the HIV/AIDS epidemic, injection drug users (IDUs) had had better access to sterile syringes, much of the epidemic among IDUs in the U.S. could have been prevented. In the context of preventing infectious diseases, 100% syringe coverage—that is, one sterile syringe per injector for each injection—is a public health goal. Notably, we know little about variations in syringe coverage within the U.S. and elsewhere, or about the social and political factors that might determine this coverage. Methods Using data from Holmberg (AJPH, 1996), the 1990 United States Census, the 2000 Beth Israel National Syringe Exchange Survey (n=72), and estimates of IDUs in metropolitan areas (MSAs); (Friedman et al., 2004), we explore the impact of (1) political factors (ACT UP, outreach, early syringe exchange programme (SEP) presence, men who have sex with men (MSM) per capita, drug arrests, and police per capita); (2) local resources for SEPs; and (3) indicators of socioeconomic inequality on SEP coverage. We define “syringe coverage” as the ratio of syringes distributed at SEPs to the number of syringes heroin injectors need in a year. We calculated the number of syringes heroin injectors need in a year by multiplying an estimate of the number of IDUs in each MSA by an estimate of the average number of times heroin injectors inject heroin per year (2.8 times per day times 365 days). In this analysis, the sample was limited to 35 MSAs in which the primary drug of choice among injectors was heroin. Results SEP coverage varies greatly across MSAs, with an average of 3 syringes distributed per 100 injection events (std dev = 0.045; range: 2 syringes per 10 injection events, to 3 syringes per 10,000 injection events). In bivariate regression analyses, a 1 unit difference in the proportion of the population that was MSM per 1,000 was associated with a difference of 0.002 in SEP coverage (p=0.052); early SEP presence was associated with a difference of 0.038 in coverage (p=0.012); and having government funding was associated with a 0.040 difference in SEP coverage (p=0.021). Conclusions This analysis suggests that longer duration of SEP presence may increase syringe distribution and enhance successful programme utilization. Furthermore, MSAs with greater proportions of MSM tend to have better SEP coverage, perhaps providing further evidence that grassroots activism plays an important role in programme implementation and successful SEP coverage. This research provides evidence that government funding for SEPs contributes to better syringe coverage. PMID:18295468

Randomized controlled trial of a comprehensive stroke education program for patients and caregivers.

PubMed

Rodgers, H; Atkinson, C; Bond, S; Suddes, M; Dobson, R; Curless, R

1999-12-01

We report the findings of a randomized controlled trial to determine the effectiveness of a multidisciplinary Stroke Education Program (SEP) for patients and their informal carers. Two hundred four patients admitted with acute stroke and their 176 informal carers were randomized to receive an invitation to the SEP or to receive conventional stroke unit care. The SEP consisted of one 1-hour small group educational session for inpatients followed by six 1-hour sessions after discharge. The primary outcome measure was patient- and carer-perceived health status (SF-36) at 6 months after stroke. Knowledge of stroke, satisfaction with services, emotional outcome, disability, and handicap and were secondary outcome measures. Only 51 of 108 (47%) surviving patients randomized to the SEP completed the program, as did 20 of 93 (22%) informal carers of surviving patients. Perceived health status (Short Form 36 [SF-36] health survey) scores were similar for SEP patients and controls. Informal carers in the control group scored better on the social functioning component of the SF-36 than the SEP group (P=0.04). Patients and informal carers in the SEP group scored higher on the stroke knowledge scale than controls (patients, P=0.02; carers, P=0. 01). Patients in the SEP group were more satisfied with the information that they had received about stroke (P=0.004). There were no differences in emotional or functional outcomes between groups. Although the SEP improved patient and informal carer knowledge about stroke and patient satisfaction with some components of stroke services, this was not associated with an improvement in their perceived health status. Indeed, the social functioning of informal carers randomized to the SEP was less than in the control group.

The Relationship Between Cognitive and Non-Cognitive Variables and Academic Performance of Students in the Science Enrichment Preparation (S.E.P.) Program

NASA Astrophysics Data System (ADS)

Borden, Paula D.

This dissertation study concerned the lack of underrepresented minority students matriculating through the health professions pipeline. The term pipeline is "the educational avenue by which one must travel to successfully enter a profession" (Sullivan Alliance, 2004). There are a significant number of health professional pipeline programs based across the United States and, for the purposes of this study, a focus was placed on the Science Enrichment Preparation (S.E.P.) Program which is based at The University of North Carolina at Chapel Hill. The S.E.P. Program, is an eight-week residential summer experience, designed to support underrepresented minority pre-health students develop the competitive edge for successful admission into health professional school programs. The bedrock of this dissertation study concerned itself with the relationships between cognitive variables and non-cognitive variables and academic performance of students in the S.E.P. Program from 2005-2013. The study was undertaken to provide a clearer understanding for the NC Health Careers Access Program's (NC-HCAP) leadership with regard to variables associated with the students' academic performance in the S.E.P. Program. The data outcomes were informative for NC-HCAP in identifying cognitive and non-cognitive variables associated with student academic performance. Additionally, these findings provided direction as to what infrastructures may be put into place to more effectively support the S.E.P. participants. It is the researcher's hope this study may serve as an educational model and resource to pipeline programs and others with similar educational missions. The consequences and implications of a non-diverse healthcare workforce are high and far reaching. Without parity representation in the healthcare workforce, health disparities between racial and economic groups will likely continue to grow.

The association between neighborhood socioeconomic disadvantage and high-risk injection behavior among people who inject drugs.

PubMed

DeCuir, Jennifer; Lovasi, Gina S; El-Sayed, Abdulrahman; Lewis, Crystal Fuller

2018-02-01

Although much research has been conducted on the determinants of HIV risk behavior among people who inject drugs (PWID), the influence of the neighborhood context on high-risk injection behavior remains understudied. To address this gap in the literature, we measured associations between neighborhood socioeconomic disadvantage and high-risk injection behavior, and determined whether these associations were modified by drug-related police activity and syringe exchange program (SEP) accessibility. Our sample was comprised of 484 pharmacy-recruited PWID in New York City. Measures of neighborhood socioeconomic disadvantage were created using data from the 2006-2010 American Community Survey. Associations with high-risk injection behavior were estimated using multivariable Poisson regression. Effect modification by drug-related police activity and SEP accessibility was assessed by entering cross-product terms into adjusted models of high-risk injection behavior. Neighborhood socioeconomic disadvantage was associated with decreased receptive syringe sharing and unsterile syringe use. In neighborhoods with high drug-related police activity, associations between neighborhood disadvantage and unsterile syringe use were attenuated to the null. In neighborhoods with high SEP accessibility, neighborhood disadvantage was associated with decreased acquisition of syringes from an unsafe source. PWID in disadvantaged neighborhoods reported safer injection behaviors than their counterparts in neighborhoods that were relatively better off. The contrasting patterns of effect modification by SEP accessibility and drug-related police activity support the use of harm reduction approaches over law enforcement-based strategies for the control of blood borne virus transmission among PWID in disadvantaged urban areas. Copyright © 2017 Elsevier B.V. All rights reserved.

Effects of a structured education program on glycemic control in type 1 diabetes.

PubMed

Pacheco, Ana Paula F; Sande-Lee, Simone van de; Sandoval, Rita de Cássia B; Batista, Sônia; Marques, Jefferson L B

2017-12-01

Diabetes mellitus is associated with significant morbidity and mortality, and education is known to play a key role in managing this disease. This study addresses the effects of a structured education program (SEP) on self-care in subjects with type 1 diabetes mellitus (T1DM). The aim was to evaluate the effect of a SEP on glycemic control, knowledge, and skills associated with diabetes care in subjects with T1DM. A total of 47 adults with T1DM were followed up for 20 months (32 participated in the SEP and 15 served as a control group). The SEP consisted of workshops, individualized care, 24-hour distant support, and a questionnaire assessing knowledge of diabetes care. Glycosylated hemoglobin (HbA1c) levels were measured before and after the SEP implementation. Compared with pre-SEP levels, the mean HbA1c levels decreased by approximately 20% (21 mmol/mol) at 1 year, with a further 11% reduction (10 mmol/mol) observed 8 months later (p < 0.001). Knowledge about diabetes care increased by 37% between the pre-SEP and post-SEP questionnaires (p < 0.005). Relevant improvements occurred after SEP activities. The sustained decrease in HbA1c levels and the overall increase in knowledge and confidence regarding diabetes care reinforce the importance, necessity, and positive outcomes of a SEP intervention in T1DM.

Solar Wind Earth Exchange Project (SWEEP)

DTIC Science & Technology

2016-10-28

AFRL-AFOSR-UK-TR-2016-0035 Solar Wind Earth Exchange Project 140200 Steven Sembay UNIVERSITY OF LEICESTER Final Report 10/28/2016 DISTRIBUTION A...To) 01 Sep 2014 to 31 Aug 2016 4. TITLE AND SUBTITLE Solar Wind Earth Exchange Project (SWEEP) 5a.  CONTRACT NUMBER 5b.  GRANT NUMBER FA9550-14-1...SUPPLEMENTARY NOTES 14. ABSTRACT The grant received from AFRL/AOFSR/EOARD funded the Solar Wind Earth Exchange Project (SWEEP) at Leicester University. The goal

Intercellular Diffusion of a Fluorescent Sucrose Analog via the Septal Junctions in a Filamentous Cyanobacterium

PubMed Central

Nürnberg, Dennis J.; Mariscal, Vicente; Bornikoel, Jan; Nieves-Morión, Mercedes; Krauß, Norbert; Herrero, Antonia

2015-01-01

ABSTRACT Many filamentous cyanobacteria produce specialized nitrogen-fixing cells called heterocysts, which are located at semiregular intervals along the filament with about 10 to 20 photosynthetic vegetative cells in between. Nitrogen fixation in these complex multicellular bacteria depends on metabolite exchange between the two cell types, with the heterocysts supplying combined-nitrogen compounds but dependent on the vegetative cells for photosynthetically produced carbon compounds. Here, we used a fluorescent tracer to probe intercellular metabolite exchange in the filamentous heterocyst-forming cyanobacterium Anabaena sp. strain PCC 7120. We show that esculin, a fluorescent sucrose analog, is incorporated by a sucrose import system into the cytoplasm of Anabaena cells. The cytoplasmic esculin is rapidly and reversibly exchanged across vegetative-vegetative and vegetative-heterocyst cell junctions. Our measurements reveal the kinetics of esculin exchange and also show that intercellular metabolic communication is lost in a significant fraction of older heterocysts. SepJ, FraC, and FraD are proteins located at the intercellular septa and are suggested to form structures analogous to gap junctions. We show that a ΔsepJ ΔfraC ΔfraD triple mutant shows an altered septum structure with thinner septa but a denser peptidoglycan layer. Intercellular diffusion of esculin and fluorescein derivatives is impaired in this mutant, which also shows a greatly reduced frequency of nanopores in the intercellular septal cross walls. These findings suggest that FraC, FraD, and SepJ are important for the formation of junctional structures that constitute the major pathway for feeding heterocysts with sucrose. PMID:25784700

AIM-120 Advanced Medium Range Air-to-Air Missile (AMRAAM)

DTIC Science & Technology

2013-12-01

lilA (DAB) DAE Program Review Start Production Deliveries Complete DAOT&E (Air Force) Complete IOT &E!Captive Ca ... Initial EQuipage Milestone... IOT &E OCT 1983 N/A N/A OCT 1983 Certification FEB 1986 FEB 1986 AUG 1986 FEB 1986 Milestone IIIA (DAB) JUN 1987 JUN 1987 DEC 1987 JUN 1987 DAE...Program Review MAY 1988 MAY 1988 NOV 1988 MAY 1988 Start Production Deliveries SEP 1988 SEP 1988 MAR 1989 SEP 1988 Complete D/ IOT &E (Air Force) JAN 1989 JAN

"We want a living solution": views of harm reduction programs in black US Communities.

PubMed

Eversman, Michael H

2015-01-01

Illicit drug use in the US remains concerning, with injection drug use linked to transmission of blood-borne diseases as HIV/AIDS; persons of color, including Black Americans, experience disproportionately higher transmission rates. Harm reduction programs such as methadone and needle- and syringe-exchange (NEP/SEP) are empirically demonstrated to reduce HIV transmission, yet are believed largely opposed by Black communities. Using interview data from 21 service providers of substance abuse and related service organizations located in and/or serving predominantly populations of color, this study explored perceptions of harm reduction programming for illicit drugs and race in the US. Criticizing each program for unique reasons, respondents deemed them largely inadequate and inappropriate responses to community drug problems. While some believed these programs worsen Black communities, others believed they are becoming more accepted there. Views were informed by racial dynamics surrounding drugs in society, burdens borne by program host communities, and racialized stereotypes of drug use.

HBCU Summer Undergraduate Training Program in Prostate Cancer: A Partnership Between USU-CPDR and UDC

DTIC Science & Technology

2015-10-02

conferences. 3 BODY Task 1: Selection Process: USU-CPDR summer internship program announcements for 2015 were made at the UDC through...AD_________________ Award Number: W81XWH-14-2-0142 TITLE: HBCU Summer Undergraduate Training Program in Prostate Cancer: A Partnership Between...DATES COVERED (From - To) 30 Sep 2014 - 29 Sep 2015 4. TITLE AND SUBTITLE: HBCU Summer Undergraduate Training Program in Prostate Cancer: A Partnership

Evaluation of the Scottsdale Loop 101 automated speed enforcement demonstration program.

PubMed

Shin, Kangwon; Washington, Simon P; van Schalkwyk, Ida

2009-05-01

Speeding is recognized as a major contributing factor in traffic crashes. In order to reduce speed-related crashes, the city of Scottsdale, Arizona implemented the first fixed-camera photo speed enforcement program (SEP) on a limited access freeway in the US. The 9-month demonstration program spanning from January 2006 to October 2006 was implemented on a 6.5 mile urban freeway segment of Arizona State Route 101 running through Scottsdale. This paper presents the results of a comprehensive analysis of the impact of the SEP on speeding behavior, crashes, and the economic impact of crashes. The impact on speeding behavior was estimated using generalized least square estimation, in which the observed speeds and the speeding frequencies during the program period were compared to those during other periods. The impact of the SEP on crashes was estimated using 3 evaluation methods: a before-and-after (BA) analysis using a comparison group, a BA analysis with traffic flow correction, and an empirical Bayes BA analysis with time-variant safety. The analysis results reveal that speeding detection frequencies (speeds> or =76 mph) increased by a factor of 10.5 after the SEP was (temporarily) terminated. Average speeds in the enforcement zone were reduced by about 9 mph when the SEP was implemented, after accounting for the influence of traffic flow. All crash types were reduced except rear-end crashes, although the estimated magnitude of impact varies across estimation methods (and their corresponding assumptions). When considering Arizona-specific crash related injury costs, the SEP is estimated to yield about $17 million in annual safety benefits.

Review of biased solar array - Plasma interaction studies

NASA Technical Reports Server (NTRS)

Stevens, N. J.

1981-01-01

Possible high voltage surface interactions on the Solar Electric Propulsion System (SEPS) are examined, with particular regard for potential effects on SEPS performance. The SEPS is intended for use for geosynchronous and planetary missions, and derives power from deployed solar cell arrays which are susceptible to collecting ions and electrons from the charged and thermal particle environment of space. The charge exchange plasma which provides the thrust force can also enhance the natural charged particle environment and increase interactions between the thrust system and the biased solar array surface. Tests of small arrays have shown that snapover, where current collection becomes proportional to the panel area, can be avoided by larger cell sizes. Arcing is predicted to diminish with larger array sizes, while the problems of efflux environments are noted to be as yet undefined and require further study.

Mission roles for the Solar Electric Propulsion Stage (SEPS) with the space transportation system. Volume 1: Executive summary

NASA Technical Reports Server (NTRS)

Hammock, D. M.

1975-01-01

A study was conducted to determine the characteristics of solar electric propulsion stage (SEPS) for the space transportation system. Emphasis is placed on the rationale leading to the concepts for the development and operations program which enhances the cost effectiveness of the SEPS operating with the space transportation system. The approach in describing design concepts and configurations is concerned with the decision controlling factors and selection criteria. The mission roles for the SEPS in accomplishing proposed space activities are defined.

Joint Air-to-Surface Standoff Missile (JASSM)

DTIC Science & Technology

2013-12-01

LRIP Decision/Contract Award JAN 2001 JAN 2001 JAN 2002 DEC 2001 Lot II Contract Award JAN 2002 JAN 2002 JAN 2003 NOV 2002 RAA /B-52 SEP 2002 SEP 2002...SEP 2003 SEP 2003 Milestone III OCT 2003 OCT 2003 JUL 2004 APR 2004 RAA /F-16 DEC 2003 DEC 2003 DEC 2004 DEC 2004 IOC/F/A-18 E/F JUN 2009 N/A N/A N/A...Engineering and Manufacturing Development PDRR - Program Definition and Risk Reduction RAA - Required Assets Available JASSM-ER Milestones SAR Baseline Prod

Air Force Inspection System: An Application for System-of-Systems (SOS) Engineering

DTIC Science & Technology

2014-06-19

Program, 15 Dec 11 5. AFI 10-210, Prime Base Engineer Emergency Force ( BEEF ) Program, 6 Sep 12 6. AFI 10-245, Antiterrorism (AT), 21 Sep 12 AFI 10...Aircraft Carrying Hazardous Materials, 11 Nov 94 79. AFMAN 11-226 (I), US Standard for Terminal Instrument Procedures (TERPS) 92 80. AFMAN 10

Jasmonic acid accumulation and systemic photosynthetic and electrical changes in locally burned wild type tomato, ABA-deficient sitiens mutants and sitiens pre-treated by ABA.

PubMed

Hlavinka, Jan; Nožková-Hlaváčková, Vladimíra; Floková, Kristýna; Novák, Ondřej; Nauš, Jan

2012-05-01

Burning the terminal leaflet of younger tomato (Lycopersicon esculentum Mill.) leaf caused local and systemic changes in the surface electrical potential (SEP) and gas exchange (GE) parameters. The local and systemic accumulation of endogenous abscisic acid (ABA) and jasmonic acid (JA) was measured 85 min after burning. The experiments were conducted with wild type (WT) plants, ABA-deficient mutant sitiens (SIT) and ABA pre-treated SIT plants (SITA). First changes in SEP were detected within 1.5 min after burning and were followed by a decrease in GE parameters within 3-6 min in WT, SIT and SITA plants. GE and SEP time courses of SIT were different and wave amplitudes of SEP of SIT were lower compared to WT and SITA. ABA content in WT and SITA control plants was similar and substantially higher compared to SIT, JA content was similar among WT, SIT and SITA. While changes in the ABA content in systemic leaves have not been recorded after burning, the systemic JA content was substantially increased in WT and more in SIT and SITA. The results suggest that ABA content governs the systemic reaction of GE and the SEP shape upon local burning. ABA, JA and SEP participate in triggering the GE reaction. The ABA shortage in the SIT in the reaction to burning is partly compensated by an enhanced JA accumulation. This JA compensation is maintained even in SIT endogenously supplied with ABA. A correlation between the systemic JA content and changes in GE parameters or SEP was not found. Copyright © 2012 Elsevier Masson SAS. All rights reserved.

Standard Evaluation Procedures (SEPs) and Data Entry Spreadsheet Templates (DESTs) for Endocrine Disruptor Screening Program (EDSP) Tier 1 Assays

EPA Pesticide Factsheets

This page provides information and access to Standard Evaluation Procedures (SEPs) and Data Entry Spreadsheet Templates (DESTs) developed by EPA's Office of Chemical Safety and Pollution Prevention (OCSPP).

Welding technologies as applied to nuclear manufacturing

NASA Astrophysics Data System (ADS)

Roper, J. R.

1992-10-01

This is the trip report of John R. Roper, who traveled to England 25 Sep. through 8 Oct. 1992. Dr. Roper attended the US/UK JOWOG 22-D Joining Technical Exchange meeting and gave a presentation on Welding Finite Element Analysis and the Precision Joining Center at the Atomic Weapons Establishment in Aldermaston, United Kingdom. Dr. Roper also toured the Welding Institute in Abington, UK and discussed technology exchange of weld thermal and mechanical material responses.

Intercellular diffusion of a fluorescent sucrose analog via the septal junctions in a filamentous cyanobacterium.

PubMed

Nürnberg, Dennis J; Mariscal, Vicente; Bornikoel, Jan; Nieves-Morión, Mercedes; Krauß, Norbert; Herrero, Antonia; Maldener, Iris; Flores, Enrique; Mullineaux, Conrad W

2015-03-17

Many filamentous cyanobacteria produce specialized nitrogen-fixing cells called heterocysts, which are located at semiregular intervals along the filament with about 10 to 20 photosynthetic vegetative cells in between. Nitrogen fixation in these complex multicellular bacteria depends on metabolite exchange between the two cell types, with the heterocysts supplying combined-nitrogen compounds but dependent on the vegetative cells for photosynthetically produced carbon compounds. Here, we used a fluorescent tracer to probe intercellular metabolite exchange in the filamentous heterocyst-forming cyanobacterium Anabaena sp. strain PCC 7120. We show that esculin, a fluorescent sucrose analog, is incorporated by a sucrose import system into the cytoplasm of Anabaena cells. The cytoplasmic esculin is rapidly and reversibly exchanged across vegetative-vegetative and vegetative-heterocyst cell junctions. Our measurements reveal the kinetics of esculin exchange and also show that intercellular metabolic communication is lost in a significant fraction of older heterocysts. SepJ, FraC, and FraD are proteins located at the intercellular septa and are suggested to form structures analogous to gap junctions. We show that a ΔsepJ ΔfraC ΔfraD triple mutant shows an altered septum structure with thinner septa but a denser peptidoglycan layer. Intercellular diffusion of esculin and fluorescein derivatives is impaired in this mutant, which also shows a greatly reduced frequency of nanopores in the intercellular septal cross walls. These findings suggest that FraC, FraD, and SepJ are important for the formation of junctional structures that constitute the major pathway for feeding heterocysts with sucrose. Anabaena and its relatives are filamentous cyanobacteria that exhibit a sophisticated form of prokaryotic multicellularity, with the formation of differentiated cell types, including normal photosynthetic cells and specialized nitrogen-fixing cells called heterocysts. The question of how heterocysts communicate and exchange metabolites with other cells in the filament is key to understanding this form of bacterial multicellularity. Here we provide the first information on the intercellular exchange of a physiologically important molecule, sucrose. We show that a fluorescent sucrose analog can be imported into the Anabaena cytoplasm by a sucrose import system. Once in the cytoplasm, it is rapidly and reversibly exchanged among all of the cells in the filament by diffusion across the septal junctions. Photosynthetically produced sucrose likely follows the same route from cytoplasm to cytoplasm. We identify some of the septal proteins involved in sucrose exchange, and our results indicate that these proteins form structures functionally analogous to metazoan gap junctions. Copyright © 2015 Nürnberg et al.

Impact of monetary incentives on adherence to referral for screening chest x-rays after syringe exchange-based tuberculin skin testing.

PubMed

Perlman, David C; Friedmann, Patricia; Horn, Leslie; Nugent, Anne; Schoeb, Veronika; Carey, Jeanne; Salomon, Nadim; Des Jarlais, Don C

2003-09-01

Syringe-exchange programs (SEPs) have proven to be valuable sites to conduct tuberculin skin testing among active injection drug users. Chest x-rays (CXRs) are needed to exclude active tuberculosis prior to initiating treatment for latent tuberculosis infection. Adherence of drug users to referral for off-site chest x-rays has been incomplete. Previous cost modeling demonstrated that a monetary incentive to promote adherence could be justified on the cost basis if it had even a modest effect on adherence. We compared adherence to referral for chest x-rays among injection drug users undergoing syringe exchange-based tuberculosis screening in New York City before and after the implementation of monetary incentives. From 1995 to 1998, there were 119 IDUs referred for CXRs based on tuberculin skin testing at the SEP. From 1999 to 2001, there were 58 IDUs referred for CXRs with a $25 incentive based on adherence. Adherence to CXR referral within 7 days was 46/58 (79%) among individuals who received the monetary incentive versus 17/119 (14%) prior to the implementation of the monetary incentive (P<.0001; odds ratio [OR]=23; 95% confidence interval [CI]=9.5-57). The median time to obtaining a CXR was significantly shorter among those given the incentive than among those referred without the incentive (2 vs. 11 days, P<.0001). In multivariate logistic regression analysis, use of the incentive was highly independently associated with increased adherence (OR=22.9; 95% CI=10-52). Monetary incentives are highly effective in increasing adherence to referral for screening CXRs to exclude active tuberculosis after syringe exchange-based tuberculin skin testing. Prior cost modeling demonstrated that monetary incentives could be justified on the cost basis if they had even a modest effect on adherence. The current data demonstrated that monetary incentives are highly effective at increasing adherence in this setting and therefore are justifiable on a cost basis. When health care interventions for drug users require referral off site, monetary incentives may be particularly valuable in promoting adherence.

The U.S. Navy’s Consultant Development and Qualification Program: Origin and Issues.

DTIC Science & Technology

1984-03-01

Areasoe Senior Master I Capability Intern Consultant Consultant Consultant I MARKETING Strategy 1--------------- 21 Ijplementation 1 --------- I...SENIOR MASTER INTERN CONSULTANT CONSULTANT CONSULTANT A. MARKETING A.1 Develop Marketing Strategy Program 1 11 A.2 Implement Marketing Program 1 1 1 2 A.3...Qualification Criteria for: Degree of PROFICIENCY LT 0. D. EFFORT SEP 1980 SEP 1983 Date Reported PRD 1 2 3 4 A. MARKETING A.1 Develop Marketing Strategy (1, 1

A New Enhanced Engineering Programme for Manufacturing Industries.

ERIC Educational Resources Information Center

Clark, C.; And Others

1985-01-01

Special Engineering Programmes (SEPs) were established in Great Britain to attract highly able students into engineering and to provide education/training to meet the needs of manufacturing industries. SEP philosophy and objectives, program structure, student selection, course assessment, and other areas are discussed. (JN)

Aquatic Plant Control Research Program. A Survey of the Continental United States for Pathogens of Eurasian Watermilfoil

DTIC Science & Technology

1988-04-01

Res. Old boat basin Chelan 13 Sep 1984 Rock Island Res. Mouth of Wenatchee River Chelan 13 Sep 1984 Rock Island Res. Hannah Mining Co. Douglas 13 Sep...States, including ponds, lakes, reser- voirs, rivers , and canals. At the conclusion of the survey, 792 isolates had been collected from tissue samples...acre (9-ha) pond located in Anne Arundel County, Maryland, and an area near the Northeast River in Cecil County, Maryland--and suggested the declines

Sepsis National Hospital Inpatient Quality Measure (SEP-1): Multistakeholder Work Group Recommendations for Appropriate Antibiotics for the Treatment of Sepsis.

PubMed

Septimus, Edward J; Coopersmith, Craig M; Whittle, Jessica; Hale, Caleb P; Fishman, Neil O; Kim, Thomas J

2017-10-16

The Center for Medicare and Medicaid Services adopted the Early Management Bundle, Severe Sepsis/Septic Shock (SEP-1) performance measure to the Hospital Inpatient Quality Reporting Program in July 2015 to help address the high mortality and high cost associated with sepsis. The SEP-1 performance measure requires, among other critical interventions, timely administration of antibiotics to patients with sepsis or septic shock. The multistakeholder workgroup recognizes the need for SEP-1 but strongly believes that multiple antibiotics listed in the antibiotic tables for SEP-1 are not appropriate and the use of these antibiotics, as called for in the SEP-1 measure, is not in alignment with prudent antimicrobial stewardship. To promote the appropriate use of antimicrobials and combat antimicrobial resistance, the workgroup provides recommendations for appropriate antibiotics for the treatment of sepsis. © The Author 2017. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.

The Peptidoglycan-Binding Protein SjcF1 Influences Septal Junction Function and Channel Formation in the Filamentous Cyanobacterium Anabaena.

PubMed

Rudolf, Mareike; Tetik, Nalan; Ramos-León, Félix; Flinner, Nadine; Ngo, Giang; Stevanovic, Mara; Burnat, Mireia; Pernil, Rafael; Flores, Enrique; Schleiff, Enrico

2015-06-30

Filamentous, heterocyst-forming cyanobacteria exchange nutrients and regulators between cells for diazotrophic growth. Two alternative modes of exchange have been discussed involving transport either through the periplasm or through septal junctions linking adjacent cells. Septal junctions and channels in the septal peptidoglycan are likely filled with septal junction complexes. While possible proteinaceous factors involved in septal junction formation, SepJ (FraG), FraC, and FraD, have been identified, little is known about peptidoglycan channel formation and septal junction complex anchoring to the peptidoglycan. We describe a factor, SjcF1, involved in regulation of septal junction channel formation in the heterocyst-forming cyanobacterium Anabaena sp. strain PCC 7120. SjcF1 interacts with the peptidoglycan layer through two peptidoglycan-binding domains and is localized throughout the cell periphery but at higher levels in the intercellular septa. A strain with an insertion in sjcF1 was not affected in peptidoglycan synthesis but showed an altered morphology of the septal peptidoglycan channels, which were significantly wider in the mutant than in the wild type. The mutant was impaired in intercellular exchange of a fluorescent probe to a similar extent as a sepJ deletion mutant. SjcF1 additionally bears an SH3 domain for protein-protein interactions. SH3 binding domains were identified in SepJ and FraC, and evidence for interaction of SjcF1 with both SepJ and FraC was obtained. SjcF1 represents a novel protein involved in structuring the peptidoglycan layer, which links peptidoglycan channel formation to septal junction complex function in multicellular cyanobacteria. Nonetheless, based on its subcellular distribution, this might not be the only function of SjcF1. Cell-cell communication is central not only for eukaryotic but also for multicellular prokaryotic systems. Principles of intercellular communication are well established for eukaryotes, but the mechanisms and components involved in bacteria are just emerging. Filamentous heterocyst-forming cyanobacteria behave as multicellular organisms and represent an excellent model to study prokaryotic cell-cell communication. A path for intercellular metabolite exchange appears to involve transfer through molecular structures termed septal junctions. They are reminiscent of metazoan gap junctions that directly link adjacent cells. In cyanobacteria, such structures need to traverse the peptidoglycan layers in the intercellular septa of the filament. Here we describe a factor involved in the formation of channels across the septal peptidoglycan layers, thus contributing to the multicellular behavior of these organisms. Copyright © 2015 Rudolf et al.

Mission roles for the solar electric propulsion stage with the space transportation system

NASA Technical Reports Server (NTRS)

1974-01-01

A briefing outline is presented of the mission roles for the solar electric propulsion stage (SEPS). Topics outlined include operational considerations and mission characteristics, trade studies and technology assessments influencing SEPS configuration definition, program support requirements, and development and operations cost estimates.

75 FR 6675 - Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Human...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-02-10

..., Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Human Immunodeficiency Virus (HIV... evaluation of applications received in response to ``HIV Prevention Projects for Community Based..., Extramural Programs, National Center for HIV, Hepatitis and Sexually Transmitted Diseases Prevention, 1600...

76 FR 19995 - Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Funding...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-11

..., Extramural Research Program Office, National Center for Chronic Disease Prevention and Health Promotion, CDC... DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Disease Control and Prevention Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Funding Opportunity Announcement...

76 FR 62475 - Global X Funds, et al.

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-07

...] Global X Funds, et al.; Notice of Application September 30, 2011. AGENCY: Securities and Exchange....\\1\\ \\1\\ Global X Funds and Global X Management Company LLC, Investment Company Act Release Nos. 28378 (Sep. 10, 2008) (notice) and 28433 (Oct. 3, 2008) (order). Applicants: Global X Funds (the ``Trust...

75 FR 7281 - Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Translating...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-02-18

... DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Disease Control and Prevention Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Translating Research Into Action... of the Director, Extramural Research Program Office, 4770 Buford Highway, NE., Mailstop K-92, Atlanta...

Early experience of a novel-environment in isolation primes a fearful phenotype characterized by persistent amygdala activation.

PubMed

Daskalakis, Nikolaos P; Diamantopoulou, Anastasia; Claessens, Sanne E F; Remmers, Elisa; Tjälve, Marika; Oitzl, Melly S; Champagne, Danielle L; de Kloet, E Ronald

2014-01-01

Prolonged maternal separation (MS) activates the neonate's hypothalamus-pituitary-adrenal axis causing elevated basal and stress-induced corticosterone levels that may initiate amygdala-dependent fear learning. Here we test the hypothesis that the adult fearful phenotype is programmed by the pup's stressful experience during prolonged MS rather than by prolonged maternal absence per se. For this purpose, Wistar rat pups were exposed, on postnatal-day (pnd) 3, to: (i) repeated-MS in home-environment (HOME-SEP), 8h-MS daily for three days with the pups remaining together in the home-cage; (ii) repeated-MS in a novel-environment (NOVEL-SEP), with the same separation procedure, but now the pups were individually housed in a novel-environment during the 8h dam's absence; (iii) repeated handling, which consisted of daily brief (15 min instead of 8h) MS in the home-altogether or in a novel-environment individually (HOME-HAN and NOVEL-HAN, respectively); (iv) no-separation/no-handling (NON-SEP/NON-HAN) control condition, in which pups were left undisturbed in their home-cage. Compared to HOME-SEP rats, the NOVEL-SEP rats showed one day after the last MS enhanced stress-induced amygdala c-Fos expression and ACTH-release, despite of reduced adrenal corticosterone secretion. The higher amygdala c-Fos expression, ACTH-release and reduced corticosterone output observed postnatally, persisted into adulthood of the NOVEL-SEP animals. Behaviorally, NOVEL-SEP juvenile rats displayed deficits in social play, had intact spatial memory in the peri-pubertal period and showed more contextual fear memory compared to HOME-SEP in adulthood. Finally, NOVEL-HAN, compared to HOME-HAN, displayed increased stress-induced corticosterone output, no deficits in social play and reduced contextual fear. In conclusion, programming of an adult fearful phenotype linked to amygdala priming develops if pups are repeatedly isolated from peers in a novel-environment, while away from the dam for a prolonged period of time. Copyright © 2013 Elsevier Ltd. All rights reserved.

32 CFR 191.1 - Purpose.

Code of Federal Regulations, 2014 CFR

2014-07-01

... EEO Program, the establishment of Special Emphasis Programs (SEPs) entitled the Federal Women's...), the Asian/Pacific Islander Employment Program (AEP), the American Indian/Alaskan Native Employment...

32 CFR 191.1 - Purpose.

Code of Federal Regulations, 2012 CFR

2012-07-01

... EEO Program, the establishment of Special Emphasis Programs (SEPs) entitled the Federal Women's...), the Asian/Pacific Islander Employment Program (AEP), the American Indian/Alaskan Native Employment...

32 CFR 191.1 - Purpose.

Code of Federal Regulations, 2013 CFR

2013-07-01

... EEO Program, the establishment of Special Emphasis Programs (SEPs) entitled the Federal Women's...), the Asian/Pacific Islander Employment Program (AEP), the American Indian/Alaskan Native Employment...

A Compendium of Air Force Institute of Technology Thesis Abstracts Related to Acquisition Management

DTIC Science & Technology

1990-09-01

SHOULD PROGRAM DIRECTORS BE GRANTED CONTRACTING AUTHORITY? Champlain, George F. Sep 89 AD-A216 357 ABSTRACT: In Air Force Systems Command (AFSC...COMPETITIVE PRICES IN THE ACQUISITION OF WEAPON SYSTEM REPLENISHMENT SPARE PARTS. Brost , Edward J, Sep 82 AD-A122 962 ABSTRACT: Competition is the

Role of Two Cell Wall Amidases in Septal Junction and Nanopore Formation in the Multicellular Cyanobacterium Anabaena sp. PCC 7120

PubMed Central

Bornikoel, Jan; Carrión, Alejandro; Fan, Qing; Flores, Enrique; Forchhammer, Karl; Mariscal, Vicente; Mullineaux, Conrad W.; Perez, Rebeca; Silber, Nadine; Wolk, C. Peter; Maldener, Iris

2017-01-01

Filamentous cyanobacteria have developed a strategy to perform incompatible processes in one filament by differentiating specialized cell types, N2-fixing heterocysts and CO2-fixing, photosynthetic, vegetative cells. These bacteria can be considered true multicellular organisms with cells exchanging metabolites and signaling molecules via septal junctions, involving the SepJ and FraCD proteins. Previously, it was shown that the cell wall lytic N-acetylmuramyl-L-alanine amidase, AmiC2, is essential for cell–cell communication in Nostoc punctiforme. This enzyme perforates the septal peptidoglycan creating an array of nanopores, which may be the framework for septal junction complexes. In Anabaena sp. PCC 7120, two homologs of AmiC2, encoded by amiC1 and amiC2, were identified and investigated in two different studies. Here, we compare the function of both AmiC proteins by characterizing different Anabaena amiC mutants, which was not possible in N. punctiforme, because there the amiC1 gene could not be inactivated. This study shows the different impact of each protein on nanopore array formation, the process of cell–cell communication, septal protein localization, and heterocyst differentiation. Inactivation of either amidase resulted in significant reduction in nanopore count and in the rate of fluorescent tracer exchange between neighboring cells measured by FRAP analysis. In an amiC1 amiC2 double mutant, filament morphology was affected and heterocyst differentiation was abolished. Furthermore, the inactivation of amiC1 influenced SepJ localization and prevented the filament-fragmentation phenotype that is characteristic of sepJ or fraC fraD mutants. Our findings suggest that both amidases are to some extent redundant in their function, and describe a functional relationship of AmiC1 and septal proteins SepJ and FraCD. PMID:28929086

Role of Two Cell Wall Amidases in Septal Junction and Nanopore Formation in the Multicellular Cyanobacterium Anabaena sp. PCC 7120.

PubMed

Bornikoel, Jan; Carrión, Alejandro; Fan, Qing; Flores, Enrique; Forchhammer, Karl; Mariscal, Vicente; Mullineaux, Conrad W; Perez, Rebeca; Silber, Nadine; Wolk, C Peter; Maldener, Iris

2017-01-01

Filamentous cyanobacteria have developed a strategy to perform incompatible processes in one filament by differentiating specialized cell types, N 2 -fixing heterocysts and CO 2 -fixing, photosynthetic, vegetative cells. These bacteria can be considered true multicellular organisms with cells exchanging metabolites and signaling molecules via septal junctions, involving the SepJ and FraCD proteins. Previously, it was shown that the cell wall lytic N -acetylmuramyl-L-alanine amidase, AmiC2, is essential for cell-cell communication in Nostoc punctiforme . This enzyme perforates the septal peptidoglycan creating an array of nanopores, which may be the framework for septal junction complexes. In Anabaena sp. PCC 7120, two homologs of AmiC2, encoded by amiC1 and amiC2 , were identified and investigated in two different studies. Here, we compare the function of both AmiC proteins by characterizing different Anabaena amiC mutants, which was not possible in N. punctiforme , because there the amiC1 gene could not be inactivated. This study shows the different impact of each protein on nanopore array formation, the process of cell-cell communication, septal protein localization, and heterocyst differentiation. Inactivation of either amidase resulted in significant reduction in nanopore count and in the rate of fluorescent tracer exchange between neighboring cells measured by FRAP analysis. In an amiC1 amiC2 double mutant, filament morphology was affected and heterocyst differentiation was abolished. Furthermore, the inactivation of amiC1 influenced SepJ localization and prevented the filament-fragmentation phenotype that is characteristic of sepJ or fraC fraD mutants. Our findings suggest that both amidases are to some extent redundant in their function, and describe a functional relationship of AmiC1 and septal proteins SepJ and FraCD.

Steroids in porcine follicular fluid: analysis by HPLC, capillary CG and capillary CG/MS after purification on SEP-PAK C18 and ion exchange chromatography.

PubMed

Khalil, M W; Lawson, V

1983-04-01

Steroids in porcine follicular fluid have been concentrated by reverse phase chromatography in SEP-PAK C18 and purified further on the cation exchanger SP-Sephadex C-25. Fractionation into unconjugated neutral and phenolic steroids, glucuronides and sulfates was carried out on triethylaminohydroxypropyl Sephadex LH-20 (TEAP-LH-20). The unconjugated neutral fraction was analysed by high pressure liquid chromatography (HPLC) on a C18 radial cartridge 5 mm I.D.; 10 mu, or on a C18 5 mu RESOLVE column, and by capillary gas chromatography (GC) on a 12 M OV-1 cross linked fused silica column. Testosterone, progesterone and androstenedione were the major steroids detected by HPLC monitored at 254 nm, although 17- hydroxy-, 20 alpha-dihydro- and 20 beta-dihydroprogesterone were also present. Pregnenolone, pregnanediol, dehydroepiandrosterone, 17-hydroxypregnenolone and androsterone were detected by capillary CG as their 0-methyloxime trimethylsilyether derivatives. Further confirmation of structure was provided by complete mass spectral data or by selective ion monitoring (SIM).

Summer enrichment partnership (SEP) - society of hispanic professional engineers (SHPE)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Vela, C.E.

1994-12-31

SEP recruits talented Hispanic high school students in the Washington metropolitan area and seeks to increase the number of Hispanics who enter graduate programs in engineering and science. New students are exposed to engineering, experimental science and business, and visit R&D centers and corporations. Returning students take college level courses, such as Vector-Based Analytic Geometry and Probability and Statistics. Advanced students work on special projects. Hispanic engineers, scientists, and managers offer career guidance. Parental participation is actively encouraged. Students are selected based on: (a) commitment to succeed, (b) academic record, and (c) willingness to attend the program through graduation. Coursesmore » are taught by university faculty, with one teacher assistant per five students. Program evaluation encompasses: (1) student participation and performance, (2) school achievement, and (3) continuation to college. SEP is a partnership between the Society of Hispanic Professional Engineers, The Catholic University of America, NASA, school districts, parents and students, and Hispanic professionals.« less

Breakthrough Capability for the NASA Astrophysics Explorer Program: Reaching the Darkest Sky

NASA Technical Reports Server (NTRS)

Greenhouse, Matthew A.; Benson, Scott W.; Falck, Robert D.; Fixsen, Dale J.; Gardner, Joseph P.; Garvin, James B.; Kruk, Jeffrey W.; Oleson, Stephen R.; Thronson, Harley A.

2012-01-01

We describe a mission architecture designed to substantially increase the science capability of the NASA Science Mission Directorate (SMD) Astrophysics Explorer Program for all AO proposers working within the near-UV to far-infrared spectrum. We have demonstrated that augmentation of Falcon 9 Explorer launch services with a 13 kW Solar Electric Propulsion (SEP) stage can deliver a 700 kg science observatory payload to extra-Zodiacal orbit. This new capability enables up to 13X increased photometric sensitivity and 160X increased observing speed relative to a Sun- Earth L2, Earth-trailing, or Earth orbit with no increase in telescope aperture. All enabling SEP stage technologies for this launch service augmentation have reached sufficient readiness (TRL-6) for Explorer Program application in conjunction with the Falcon 9. We demonstrate that enabling Astrophysics Explorers to reach extra-zodiacal orbit will allow this small payload program to rival the science performance of much larger long development time systems; thus, providing a means to realize major science objectives while increasing the SMD Astrophysics portfolio diversity and resiliency to external budget pressure. The SEP technology employed in this study has strong applicability to SMD Planetary Science community-proposed missions. SEP is a stated flight demonstration priority for NASA's Office of the Chief Technologist (OCT). This new mission architecture for astrophysics Explorers enables an attractive realization of joint goals for OCT and SMD with wide applicability across SMD science disciplines.

Optimal low thrust geocentric transfer. [mission analysis computer program

NASA Technical Reports Server (NTRS)

Edelbaum, T. N.; Sackett, L. L.; Malchow, H. L.

1973-01-01

A computer code which will rapidly calculate time-optimal low thrust transfers is being developed as a mission analysis tool. The final program will apply to NEP or SEP missions and will include a variety of environmental effects. The current program assumes constant acceleration. The oblateness effect and shadowing may be included. Detailed state and costate equations are given for the thrust effect, oblateness effect, and shadowing. A simple but adequate model yields analytical formulas for power degradation due to the Van Allen radiation belts for SEP missions. The program avoids the classical singularities by the use of equinoctial orbital elements. Kryloff-Bogoliuboff averaging is used to facilitate rapid calculation. Results for selected cases using the current program are given.

Preventing Prostate Cancer Metastasis by Targeting Exosome Secretion

DTIC Science & Technology

2014-10-01

Exosome Secretion PRINCIPAL INVESTIGATOR: Christine Vogel CONTRACTING ORGANIZATION: New York University, New York, NY 10012...30 Sep 2013 - 29 Sep 2014 4. TITLE AND SUBTITLE Preventing Prostate Cancer Metastasis by Targeting Exosome Secretion 5a. CONTRACT...NUMBER Preventing Prostate Cancer Metastasis by Targeting Exosome Secretion 5b. GRANT NUMBER W81XWH-13-1-0467 5c. PROGRAM ELEMENT

Solar Energetic Particle Event Risks for Future Human Missions within the Inner Heliosphere

NASA Astrophysics Data System (ADS)

Over, S.; Ford, J.

2017-12-01

As astronauts travel beyond low-Earth orbit (LEO), space weather research will play a key role in determining risks from space radiation. Of interest are the rare, large solar energetic particle (SEP) events that can cause significant medical effects during flight. Historical SEP data were analyzed from the Geostationary Operational Environmental Satellites (GOES) program covering the time period of 1986 to 2016 for SEP events. The SEP event data were combined with a Monte Carlo approach to develop a risk model to determine maximum expected doses for missions within the inner heliosphere. Presented here are results from risk assessments for proposed Mars transits as compared to a geostationary Earth-bound mission. Overall, the greatest risk was for the return from Mars with a Venus swing-by, due to the additional transit length and decreased distance from the Sun as compared to traditional Hohmann transfers. The overall results do not indicate that the effects of SEP events alone would prohibit these missions based on current radiation limits alone, but the combination of doses from SEP events and galactic cosmic radiation may be significant, and should be considered in all phases of mission design.

Implications of the S-Web Model for Impulsive SEPs

NASA Astrophysics Data System (ADS)

Antiochos, Spiro K.; Higginson, Aleida K.; DeVore, C. Richard

2017-08-01

One of the most important discoveries of the STEREO mission is that impulsive Solar Energetic Particle (SEP) events frequently exhibit large longitudinal spread in the heliosphere, up to 100 degrees or more. This result is especially puzzling given the long-standing observations that impulsive SEPs originate in highly localized regions in the corona, angular extent less than one degree, and that the SEPs frequently show so-called drop-outs, effectively ruling out diffusion as a mechanism for the observed spread. We discuss the implications of the S-Web slow solar wind model for the propagation of SEPs and their distribution in the heliosphere. We present results from 3D MHD simulations demonstrating that for commonly-observed coronal magnetic topologies, the connectivity of the corona to heliosphere will be quasi-singular, with small regions near the Sun dynamically connecting to giant arcs in the heliosphere that span tens of degrees in both latitude and longitude. We show that the S-Web model can account for both SEP longitudinal spread and dropouts, and discuss implications for observations from the upcoming Solar Orbiter and Solar Probe Plus missions.This research was supported, in part, by the NASA LWS Program.

32 CFR 191.1 - Purpose.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Charter. (b) Consolidates in a single document provisions of Secretary of Defense Multiple Addressee... EEO Program, the establishment of Special Emphasis Programs (SEPs) entitled the Federal Women's...

Elastic scattering and vibrational excitation for electron impact on para-benzoquinone

NASA Astrophysics Data System (ADS)

Jones, D. B.; Blanco, F.; García, G.; da Costa, R. F.; Kossoski, F.; Varella, M. T. do N.; Bettega, M. H. F.; Lima, M. A. P.; White, R. D.; Brunger, M. J.

2017-12-01

We report on theoretical elastic and experimental vibrational-excitation differential cross sections (DCSs) for electron scattering from para-benzoquinone (C6H4O2), in the intermediate energy range 15-50 eV. The calculations were conducted with two different theoretical methodologies, the Schwinger multichannel method with pseudopotentials (SMCPP) and the independent atom method with screening corrected additivity rule (IAM-SCAR) that also now incorporates a further interference (I) term. The SMCPP with N energetically open electronic states (Nopen) at the static-exchange-plus-polarisation (Nopench-SEP) level was used to calculate the scattering amplitudes using a channel coupling scheme that ranges from 1ch-SE up to the 89ch-SEP level of approximation. We found that in going from the 38ch-SEP to the 89ch-SEP, at all energies considered here, the elastic DCSs did not change significantly in terms of both their shapes and magnitudes. This is a good indication that our SMCPP 89ch-SEP elastic DCSs are converged with respect to the multichannel coupling effect for the investigated intermediate energies. While agreement between our IAM-SCAR+I and SMCPP 89ch-SEP computations improves as the incident electron energy increases from 15 eV, overall the level of accord is only marginal. This is particularly true at middle scattering angles, suggesting that our SCAR and interference corrections are failing somewhat for this molecule below 50 eV. We also report experimental DCS results, using a crossed-beam apparatus, for excitation of some of the unresolved ("hybrid") vibrational quanta (bands I-III) of para-benzoquinone. Those data were derived from electron energy loss spectra that were measured over a scattered electron angular range of 10°-90° and put on an absolute scale using our elastic SMCPP 89ch-SEP DCS results. The energy resolution of our measurements was ˜80 meV, which is why, at least in part, the observed vibrational features were only partially resolved. To the best of our knowledge, there are no other experimental or theoretical vibrational excitation results against which we might compare the present measurements.

SEP thrust subsystem performance sensitivity analysis

NASA Technical Reports Server (NTRS)

Atkins, K. L.; Sauer, C. G., Jr.; Kerrisk, D. J.

1973-01-01

This is a two-part report on solar electric propulsion (SEP) performance sensitivity analysis. The first part describes the preliminary analysis of the SEP thrust system performance for an Encke rendezvous mission. A detailed description of thrust subsystem hardware tolerances on mission performance is included together with nominal spacecraft parameters based on these tolerances. The second part describes the method of analysis and graphical techniques used in generating the data for Part 1. Included is a description of both the trajectory program used and the additional software developed for this analysis. Part 2 also includes a comprehensive description of the use of the graphical techniques employed in this performance analysis.

Overview of European and other non-US/USSR/Japan launch vehicle and propulsion technology programs

NASA Technical Reports Server (NTRS)

Rice, Eric E.

1991-01-01

The following subject areas are covered: majority of propulsion technology development work is directly related to the ESA's Ariane 5 program and heavily involves SEP (Societe Europeenne de Propulsion) in all areas; Hermes; advanced work on magnetic bearings for turbomachinery; electric propulsion using Cs and Xe propellants done by SEP in France, MBB ERNO in West Germany, and by Culham Lab in UK; successfully tested fired H/O composite nozzle exit cone on 3rd stage of Ariane; turbine blades made of composites to allow increase in gas temperature and improvement in efficiency; combined cycle (turboramjet-rocket) engine analysis work done by Hyperspace; and ESA advanced program studies.

SEP ENCKE-87 and Halley rendezvous studies and improved S/C model implementation in HILTOP

NASA Technical Reports Server (NTRS)

Horsewood, J. L.; Mann, F. I.

1978-01-01

Studies were conducted to determine the performance requirements for projected state-of-the-art SEP spacecrafts boosted by the Shuttle/IUS to perform a rendezvous with the comet Halley and a rendezvous with the comet Encke during its 1977 apparition. The spacecraft model of the standard HILTOP computer program was assumed. Numerical and graphical results summarizing the studies are presented.

BOREAS TE-5 Leaf Gas Exchange Data

NASA Technical Reports Server (NTRS)

Hall, Forrest G. (Editor); Curd, Shelaine (Editor); Ehleriinger, Jim; Brooks, J. Renee; Flanagan, Larry

2000-01-01

The BOREAS TE-5 team collected measurements in the NSA and SSA on gas exchange, gas composition, and tree growth. The leaf photosynthetic gas exchange data were collected in the BOREAS NSA and the SSA from 06-Jun- 1994 to 13-Sep- 1994 using a LI-COR 6200 portable photosynthesis system. The data were collected to compare the photosynthetic capacity, stomata] conductance, and leaf intercellular CO, concentrations among the major tree species at the BOREAS sites. The data are average values from diurnal measurements on the upper canopy foliage (sun leaves). The data are available in tabular ASCII files. The data files are available on a CD-ROM (see document number 20010000884), or from the Oak Ridge National Laboratory (ORNL) Distributed Activity Archive Center (DAAC).

[The distribution of cardiovascular risk factors in employees from small- and medium-sized enterprises in Germany].

PubMed

Kaifie, Andrea; Kraus, Thomas

2018-02-01

The German Prevention Act, the main parts of which came into force on 25 July 2015, encourages health promotion and prevention programs for people in their living environment. Through this act, preventive measures could reach employees at work that hardly seek medical services. This is of importance since employees with a low occupational position often show risk factors that increase morbidity and mortality. In this study, clinical data from n = 2280 employees from small and medium sized enterprises (SME) were analyzed for economic sector, sex, socioeconomic position (SEP), economic sector cardiovascular risk factors, musculoskeletal and psychological diseases. The socioeconomic position was categorized using the European Socioeconomic Classification into an intermediate/high and a low SEP category. Male employees showed a significantly higher occurrence of risk factors, such as smoking, diabetes or hypertension in comparison to female employees. In the manufacturing industry, male employees with a low SEP showed a higher prevalence of diabetes (2.3 vs. 5.9%), smoking (27.4 vs. 46.5%), and physical inactivity (sports: 55.0 vs. 37.1%) in comparison to employees with an intermediate/high SEP. Male employees with a low SEP from health and social services reported psychiatric disorders more frequently in comparison to those with an intermediate/high SEP (0.7 vs. 5.9%). Male employees with a low SEP should be given special consideration in the implementation of preventive measures at work within the framework of the Prevention Act.

75 FR 55806 - Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Patient...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-14

... Care Act (PPACA), Emerging Infections Program (EIP), Enhancing Epidemiology and Laboratory Capacity... (PPACA), Emerging Infections Program (EIP), Enhancing Epidemiology and Laboratory Capacity, Funding...

Integrative relational machine-learning for understanding drug side-effect profiles

PubMed Central

2013-01-01

Background Drug side effects represent a common reason for stopping drug development during clinical trials. Improving our ability to understand drug side effects is necessary to reduce attrition rates during drug development as well as the risk of discovering novel side effects in available drugs. Today, most investigations deal with isolated side effects and overlook possible redundancy and their frequent co-occurrence. Results In this work, drug annotations are collected from SIDER and DrugBank databases. Terms describing individual side effects reported in SIDER are clustered with a semantic similarity measure into term clusters (TCs). Maximal frequent itemsets are extracted from the resulting drug x TC binary table, leading to the identification of what we call side-effect profiles (SEPs). A SEP is defined as the longest combination of TCs which are shared by a significant number of drugs. Frequent SEPs are explored on the basis of integrated drug and target descriptors using two machine learning methods: decision-trees and inductive-logic programming. Although both methods yield explicit models, inductive-logic programming method performs relational learning and is able to exploit not only drug properties but also background knowledge. Learning efficiency is evaluated by cross-validation and direct testing with new molecules. Comparison of the two machine-learning methods shows that the inductive-logic-programming method displays a greater sensitivity than decision trees and successfully exploit background knowledge such as functional annotations and pathways of drug targets, thereby producing rich and expressive rules. All models and theories are available on a dedicated web site. Conclusions Side effect profiles covering significant number of drugs have been extracted from a drug ×side-effect association table. Integration of background knowledge concerning both chemical and biological spaces has been combined with a relational learning method for discovering rules which explicitly characterize drug-SEP associations. These rules are successfully used for predicting SEPs associated with new drugs. PMID:23802887

Integrative relational machine-learning for understanding drug side-effect profiles.

PubMed

Bresso, Emmanuel; Grisoni, Renaud; Marchetti, Gino; Karaboga, Arnaud Sinan; Souchet, Michel; Devignes, Marie-Dominique; Smaïl-Tabbone, Malika

2013-06-26

Drug side effects represent a common reason for stopping drug development during clinical trials. Improving our ability to understand drug side effects is necessary to reduce attrition rates during drug development as well as the risk of discovering novel side effects in available drugs. Today, most investigations deal with isolated side effects and overlook possible redundancy and their frequent co-occurrence. In this work, drug annotations are collected from SIDER and DrugBank databases. Terms describing individual side effects reported in SIDER are clustered with a semantic similarity measure into term clusters (TCs). Maximal frequent itemsets are extracted from the resulting drug x TC binary table, leading to the identification of what we call side-effect profiles (SEPs). A SEP is defined as the longest combination of TCs which are shared by a significant number of drugs. Frequent SEPs are explored on the basis of integrated drug and target descriptors using two machine learning methods: decision-trees and inductive-logic programming. Although both methods yield explicit models, inductive-logic programming method performs relational learning and is able to exploit not only drug properties but also background knowledge. Learning efficiency is evaluated by cross-validation and direct testing with new molecules. Comparison of the two machine-learning methods shows that the inductive-logic-programming method displays a greater sensitivity than decision trees and successfully exploit background knowledge such as functional annotations and pathways of drug targets, thereby producing rich and expressive rules. All models and theories are available on a dedicated web site. Side effect profiles covering significant number of drugs have been extracted from a drug ×side-effect association table. Integration of background knowledge concerning both chemical and biological spaces has been combined with a relational learning method for discovering rules which explicitly characterize drug-SEP associations. These rules are successfully used for predicting SEPs associated with new drugs.

77 FR 14509 - State Energy Program and Energy Efficiency and Conservation Block Grant (EECBG) Program; Request...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-12

... DEPARTMENT OF ENERGY [Docket No. EESEP0216] State Energy Program and Energy Efficiency and Conservation Block Grant (EECBG) Program; Request for Information AGENCY: Office of Energy Efficiency and... (SEP) and Energy Efficiency and Conservation Block Grant (EECBG) program, in support of energy...

BOREAS TGB-4 NSA-BVP Tower Flux and Meteorological Data

NASA Technical Reports Server (NTRS)

Roulet, Nigel T.; Hall, Forrest G. (Editor); Huemmrich, Karl (Editor); Conrad, Sara K. (Editor)

2000-01-01

The BOReal Ecosystem-Atmosphere Study Trace Gas Biogeochemistry (BOREAS TGB-4) team measured the exchange of heat, water, and CO2 between a boreal forest beaver pond and the atmosphere in the Northern Study Area (NSA) for the ice-free period of BOREAS. The data cover the period of 28-May to 18-Sep-1994. The data are available in tabular ASCII files.

75 FR 39033 - Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Patient...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-07

... Care Act (PPACA), Emerging Infections Program (EIP), Enhancing Epidemiology and Laboratory Capacity... Program (EIP), Enhancing Epidemiology and Laboratory Capacity, Funding Opportunity Announcement FOA CI10...

Global Emerging Infection Surveillance and Response (GEIS)- Avian Influenza Pandemic Influenza (AI/PI) Program

DTIC Science & Technology

2008-10-01

the fact that acute respiratory infections are one of the leading causes of morbidity. This capability now exists in Kenya with the first site brought...AD_________________ Award Number: W81XWH-07-2-0082 TITLE: Global Emerging Infection Surveillance and Response (GEIS)- Avian...TYPE Annual 3. DATES COVERED 13 Sep 07 – 12 Sep 08 4. TITLE AND SUBTITLE Global Emerging Infection Surveillance and Response (GEIS)- Avian

High Fidelity Simulation of Atomization in Diesel Engine Sprays

DTIC Science & Technology

2015-09-01

ARL-RP-0555 ● SEP 2015 US Army Research Laboratory High Fidelity Simulation of Atomization in Diesel Engine Sprays by L Bravo...ARL-RP-0555 ● SEP 2015 US Army Research Laboratory High Fidelity Simulation of Atomization in Diesel Engine Sprays by L...Simulation of Atomization in Diesel Engine Sprays 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) L Bravo, CB Ivey, D

Department of Defense Facilities Sustainment, Restoration, & Modernization Program Plan

DTIC Science & Technology

2009-05-15

Insul System and Roof $509 E 44090005 N/ A N/ A Jun-09 Sep-09...CA Repair Substation and Switchgear, Fac 2143 $5,179 E BAEY060036 N/ A N/ A Jun-09 Oct-09 Dec-10 135 Edwards AFB CA Construct Concrete Pad for Civil...Helo Hangar Fire Suppression, Bldg. 609 $848 O QSEU090104 N/ A N/ A Jun-09 Jun-09 Sep-09 578 Moody AFB GA Repair Airfield Electrical System

Meteorological Error Budget Using Open Source Data

DTIC Science & Technology

2016-09-01

ARL-TR-7831 ● SEP 2016 US Army Research Laboratory Meteorological Error Budget Using Open- Source Data by J Cogan, J Smith, P...needed. Do not return it to the originator. ARL-TR-7831 ● SEP 2016 US Army Research Laboratory Meteorological Error Budget Using...Error Budget Using Open-Source Data 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) J Cogan, J Smith, P Haines

High Energy Particle Events in Solar Cycles 23 and 24

NASA Astrophysics Data System (ADS)

Thakur, N.; Gopalswamy, N.; Makela, P. A.; Yashiro, S.; Akiyama, S.; Xie, H.

2014-12-01

We present a study of high-energy solar energetic particle (SEP) events in solar cycles 23 and 24 using GOES data. We selected large SEP events, which showed intensity enhancements in the >500 MeV and >700 MeV GOES energy channels. A study of cycle 24 and the first half of cycle 23 ground level enhancements (GLEs) by Gopalswamy et al. 2014 showed that typically, SEP events with intensity enhancement at >700 MeV have been associated with GLEs. We have extended the survey to cover the whole cycle 23. Our preliminary survey confirms this to be true for all except for three cases. There were two GLEs (1998/05/06 and 2006/12/06) for which a clear increase in >700 MeV protons was not observed by GOES. There was one high energy SEP event (2000/11/08), for which GOES observed >700 MeV protons but no GLE was produced. Here we compare all the high-energy particle events from cycles 23 and 24 with GLEs. We also compare energy spectra of all high-energy SEP events with those that produced GLEs. Work supported by NASA's Living with a Star Program. Ref.: Gopalswamy et al. 2014, GRL, 41, 2673

Breakthrough Capability for UVOIR Space Astronomy: Reaching the Darkest Sky

NASA Technical Reports Server (NTRS)

Greenhouse, Matthew A.; Benson, Scott W.; Englander, Jacob; Falck, Robert D.; Fixsen, Dale J.; Gardner, Jonathan P.; Kruk, Jeffery W.; Oleson, Steven R.; Thronson, Harley A.

2015-01-01

We describe how availability of new solar electric propulsion (SEP) technology can substantially increase the science capability of space astronomy missions working within the near-UV to far-infrared (UVOIR) spectrum by making dark sky orbits accessible for the first time. We present two case studies in which SEP is used to enable a 700 kg Explorer-class and 7000 kg flagship-class observatory payload to reach an orbit beyond where the zodiacal dust limits observatory sensitivity. The resulting scientific performance advantage relative to a Sun-Earth L2 point (SEL2) orbit is presented and discussed. We find that making SEP available to astrophysics Explorers can enable this small payload program to rival the science performance of much larger long development-time systems. Similarly, we find that astrophysics utilization of high power SEP being developed for the Asteroid Redirect Robotics Mission (ARRM) can have a substantial impact on the sensitivity performance of heavier flagship-class astrophysics payloads such as the UVOIR successor to the James Webb Space Telescope.

Solar Electric Propulsion Vehicle Design Study for Cargo Transfer to Earth-moon L1

NASA Technical Reports Server (NTRS)

Sarver-Verhey, Timothy R.; Kerslake, Thomas W.; Rawlin, Vincent K.; Falck, Robert D.; Dudzinski, Leonard J.; Oleson, Steven R.

2002-01-01

A design study for a cargo transfer vehicle using solar electric propulsion was performed for NASA's Revolutionary Aerospace Systems Concepts program. Targeted for 2016, the solar electric propulsion (SEP) transfer vehicle is required to deliver a propellant supply module with a mass of approximately 36 metric tons from Low Earth Orbit to the first Earth-Moon libration point (LL1) within 270 days. Following an examination of propulsion and power technology options, a SEP transfer vehicle design was selected that incorporated large-area (approx. 2700 sq m) thin film solar arrays and a clustered engine configuration of eight 50 kW gridded ion thrusters mounted on an articulated boom. Refinement of the SEP vehicle design was performed iteratively to properly estimate the required xenon propellant load for the out-bound orbit transfer. The SEP vehicle performance, including the xenon propellant estimation, was verified via the SNAP trajectory code. Further efforts are underway to extend this system model to other orbit transfer missions.

75 FR 18848 - Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Prevention...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-13

... Comparative Effectiveness Research Program, DP 10-003, Initial Review In accordance with Section 10(a)(2) of... to ``Prevention Research Centers Comparative Effectiveness Research Program, DP 10-003.'' Contact...

76 FR 18555 - Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Initial Review

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-04

... announced below concerns Economic Studies of Vaccines and Immunization Policies, Programs, and Practices... to ``Economic Studies of Vaccines and Immunization Policies, Programs, and Practices, FOA IP11-007...

Director's discretionary fund

NASA Technical Reports Server (NTRS)

1993-01-01

This technical memorandum contains brief technical papers describing research and technology development programs sponsored by the ARC Director's Discretionary Fund during fiscal year 1992 (Oct. 1991 through Sep. 1992). An appendix provides administrative information for each of the 45 sponsored research programs.

A Compiler and Run-time System for Network Programming Languages

DTIC Science & Technology

2012-01-01

A Compiler and Run-time System for Network Programming Languages Christopher Monsanto Princeton University Nate Foster Cornell University Rob...Foster, R. Harrison, M. Freedman, C. Monsanto , J. Rexford, A. Story, and D. Walker. Frenetic: A network programming language. In ICFP, Sep 2011. [10] A

32 CFR 191.7 - Civilian EEO program staff.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 32 National Defense 2 2010-07-01 2010-07-01 false Civilian EEO program staff. 191.7 Section 191.7...) MISCELLANEOUS THE DOD CIVILIAN EQUAL EMPLOYMENT OPPORTUNITY (EEO) PROGRAM § 191.7 Civilian EEO program staff. (a) EEO Managers, including SEP Managers and other staff who are responsible for EEO and affirmative...

32 CFR 191.7 - Civilian EEO program staff.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 32 National Defense 2 2013-07-01 2013-07-01 false Civilian EEO program staff. 191.7 Section 191.7...) MISCELLANEOUS THE DOD CIVILIAN EQUAL EMPLOYMENT OPPORTUNITY (EEO) PROGRAM § 191.7 Civilian EEO program staff. (a) EEO Managers, including SEP Managers and other staff who are responsible for EEO and affirmative...

32 CFR 191.7 - Civilian EEO program staff.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 32 National Defense 2 2011-07-01 2011-07-01 false Civilian EEO program staff. 191.7 Section 191.7...) MISCELLANEOUS THE DOD CIVILIAN EQUAL EMPLOYMENT OPPORTUNITY (EEO) PROGRAM § 191.7 Civilian EEO program staff. (a) EEO Managers, including SEP Managers and other staff who are responsible for EEO and affirmative...

32 CFR 191.7 - Civilian EEO program staff.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 32 National Defense 2 2012-07-01 2012-07-01 false Civilian EEO program staff. 191.7 Section 191.7...) MISCELLANEOUS THE DOD CIVILIAN EQUAL EMPLOYMENT OPPORTUNITY (EEO) PROGRAM § 191.7 Civilian EEO program staff. (a) EEO Managers, including SEP Managers and other staff who are responsible for EEO and affirmative...

32 CFR 191.7 - Civilian EEO program staff.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 32 National Defense 2 2014-07-01 2014-07-01 false Civilian EEO program staff. 191.7 Section 191.7...) MISCELLANEOUS THE DOD CIVILIAN EQUAL EMPLOYMENT OPPORTUNITY (EEO) PROGRAM § 191.7 Civilian EEO program staff. (a) EEO Managers, including SEP Managers and other staff who are responsible for EEO and affirmative...

AMS-02 as a Space Weather Observatory

NASA Astrophysics Data System (ADS)

Whitman, K.; Bindi, V.; Chati, M.; Consolandi, C.; Corti, C.

2013-12-01

The Alpha Magnetic Spectrometer (AMS-02) is a state-of-the-art space detector that measures particles in the energy range of hundreds of MeV to a few TeV. AMS-02 has been installed onboard of the International Space Station (ISS) since May 2011 where it will operate for the duration of the station. To date, there is an abundance of space-based solar data collected in the low energy regimes, whereas there are very few direct measurements of higher energy particles available. AMS-02 is capable of measuring arrival time and composition of the highest energy SEPs in space. It is crucial to build a better knowledge base regarding the most energetic and potentially harmful events. We are currently developing a program to employ AMS-02 as a real-time space weather observatory. SEPs with higher energies are usually accelerated during a short period of time and they are the first particles to reach the Earth. AMS-02, measuring these highest energy SEPs, can alert the onset of an SEP event. During the past two years of operation, we have identified two main quantities in AMS-02 that are particularly sensitive to the arrival of SEPs: the detector livetime and the transition radiation detector (TRD) event size. By monitoring the detector livetime and the TRD event size, AMS-02 can pinpoint in real-time the arrival of SEPs inside the Earth's magnetosphere operating as a space weather detector.

State Energy Program Fact Sheet

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

2018-02-01

The U.S. Department of Energy’s State Energy Program (SEP) provides funding and technical assistance to states, territories, and the District of Columbia to enhance energy security, advance state-led energy initiatives, and maximize the benefits of decreasing energy waste.

76 FR 24031 - Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Initial Review

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-29

... Intervention to Promote a Targeted Vaccination program in the Obstetrician- Gynecologist Setting, FOA IP11-009... a Targeted Vaccination Program in the Obstetrician-Gynecologist Setting; FOA IP11-009, initial...

Rapid synthesis of maleimide functionalized fluorine-18 labeled prosthetic group using "radio-fluorination on the Sep-Pak" method.

PubMed

Basuli, Falguni; Zhang, Xiang; Jagoda, Elaine M; Choyke, Peter L; Swenson, Rolf E

2018-06-30

Following our recently published fluorine-18 labeling method, "Radio-fluorination on the Sep-Pak", we have successfully synthesized 6-[ 18 F]fluoronicotinaldehyde by passing a solution (1:4 acetonitrile: t-butanol) of its quaternary ammonium salt precursor, 6-(N,N,N-trimethylamino)nicotinaldehyde trifluoromethanesulfonate (2), through a fluorine-18 containing anion exchange cartridge (PS-HCO 3 ). Over 80% radiochemical conversion was observed using 10 mg of precursor within 1 minute. The [ 18 F]fluoronicotinaldehyde ([ 18 F]5) was then conjugated with 1-(6-(aminooxy)hexyl)-1H-pyrrole-2,5-dione to prepare the fluorine-18 labeled maleimide functionalized prosthetic group, 6-[ 18 F]fluoronicotinaldehyde O-(6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexyl) oxime, 6-[ 18 F]FPyMHO ([ 18 F]6). The current Sep-Pak method not only improves the overall radiochemical yield (50 ± 9%, decay-corrected, n = 9) but also significantly reduces the synthesis time (from 60-90 minutes to 30 minutes) when compared with literature methods for the synthesis of similar prosthetic groups. Published 2018. This article is a U.S. Government work and is in the public domain in the USA.

48 CFR 252.232-7005 - Reimbursement of subcontractor advance payments-DoD pilot mentor-protege program.

Code of Federal Regulations, 2010 CFR

2010-10-01

... subcontractor advance payments-DoD pilot mentor-protege program. 252.232-7005 Section 252.232-7005 Federal... subcontractor advance payments—DoD pilot mentor-protege program. As prescribed in 232.412-70(c), use the following clause: Reimbursement of Subcontractor Advance Payments—DoD Pilot Mentor-Protege Program (SEP 2001...

Breakthrough Capability for UVOIR Space Astronomy: Reaching the Darkest Sky

NASA Technical Reports Server (NTRS)

Greenhouse, Matthew A.; Benson, Scott W.; Englander, Jacob; Falck, Robert D.; Fixsen, Dale J.; Gardner, Jonathan P.; Kruk, Jeffrey W.; Oleson, Steven R.; Thronson, Harley A.

2014-01-01

We describe how availability of new solar electric propulsion (SEP) technology can substantially increase the science capability of space astronomy missions working within the near-UV to far-infrared (UVOIR) spectrum by making dark sky orbits accessible for the first time. We present a proof of concept case study in which SEP is used to enable a 700 kg Explorer-class observatory payload to reach an orbit beyond where the zodiacal dust limits observatory sensitivity. The resulting scientific performance advantage relative to a Sun-Earth L2 point orbit is presented and discussed. We find that making SEP available to astrophysics Explorers can enable this small payload program to rival the science performance of much larger long development-time systems. We also present flight dynamics analysis which illustrates that this concept can be extended beyond Explorers to substantially improve the sensitivity performance of heavier (7000 kg) flagship-class astrophysics payloads such as the UVOIR successor to the James Webb Space Telescope by using high power SEP that is being developed for the Asteroid Redirect Robotics Mission.

The impacts of different long-term fertilization regimes on the bioavailability of arsenic in soil: integrating chemical approach with Escherichia coli arsRp::luc-based biosensor.

PubMed

Hou, Qi-Hui; Ma, An-Zhou; Lv, Di; Bai, Zhi-Hui; Zhuang, Xu-Liang; Zhuang, Guo-Qiang

2014-07-01

An Escherichia coli arsRp::luc-based biosensor was constructed to measure the bioavailability of arsenic (As) in soil. In previous induction experiments, it produced a linear response (R (2) = 0.96, P < 0.01) to As from 0.05 to 5 μmol/L after a 2-h incubation. Then, both chemical sequential extraction, Community Bureau of Reference recommended sequential extraction procedures (BCR-SEPs) and E. coli biosensor, were employed to assess the impact of different long-term fertilization regimes containing N, NP, NPK, M (manure), and NPK + M treatments on the bioavailability of arsenic (As) in soil. Per the BCR-SEPs analysis, the application of M and M + NPK led to a significant (P < 0.01) increase of exchangeable As (2-7 times and 2-5 times, respectively) and reducible As (1.5-2.5 times and 1.5-2.3 times, respectively) compared with the no fertilization treated soil (CK). In addition, direct contact assay of E. coli biosensor with soil particles also supported that bioavailable As in manure-fertilized (M and M + NPK) soil was significantly higher (P < 0.01) than that in CK soil (7 and 9 times, respectively). Organic carbon may be the major factor governing the increase of bioavailable As. More significantly, E. coli biosensor-determined As was only 18.46-85.17 % of exchangeable As and 20.68-90.1 % of reducible As based on BCR-SEPs. In conclusion, NKP fertilization was recommended as a more suitable regime in As-polluted soil especially with high As concentration, and this E. coli arsRp::luc-based biosensor was a more realistic approach in assessing the bioavailability of As in soil since it would not overrate the risk of As to the environment.

Impact of the "faster better cheaper" requirements for satellites components/subsystems on SEP organisation and processes.

NASA Astrophysics Data System (ADS)

Pages, X.

2000-03-01

In the early 90's, SEP environment in the satellites business quickly evolved from agencies funded programs (ESA, CNES, government) to a situation in which SEP has numerous private customers and where agencies behave as private companies i.e. opening world-wide competition, requesting high involvement of SEP in non recurring funding. SEP quickly reacted to face this challenge by improving not only their products but also the way these products are developed and produced. A new organization of SEP/DPES unit (around 200 people) was set up end 1994, with project oriented guidelines such as streamlining the hierarchical levels in order to increase personals implication and motivation, favoring flexible project organizations to the previous somewhat rigid matrix organization, enforcing commercial/marketing structure to the new customers. Highly motivated slim teams were constituted around each project, picking up expert partners inside SEP/DPES departments. Project partners proved to plead in an efficient manner with their own management on the behalf of the projects they were implied in. Eventually, this organization helped, of course with other progress actions, to a global performance improvement of SEP/DPES. Improved development processes were put into practice in 1995 among which design to cost, carefully decided internal preliminary studies, long term agreements with preferred subcontractors. SEP/DPES ISO.9001 certification (mid-1998) which gives evidence of the satisfactory status of SEP/DPES PA system already helps to avoid to costly comply with numerous project tailored P.A. requirements. New products were developed/qualified since the mid-90's, on SEP funding (at least partial, sometimes total), following the here before described processes and organization. Among SEP/DPES newly developed products, three examples are more thoroughly discussed. In the field of electrical propulsion where SEP/DPES has gained expertise in since the 60's, new developments started in the early 90's in Hall propulsion through numerous partnership with Russian, American and Italian companies and/or universities. A mature knowledge of Hall thruster functioning and technologies helped SEP to recently complete a successful qualification of their first Hall thruster. "PPS 1350" which will be in flight aboard STENTOR French technological satellite in year 2000. A cost reduction research of this new product was held in parallel to the PPS 1350 qualification, taking into account all the lessons learnt during PPS 1350 development. Its major outputs are the numerous simplifications that were found leading to dramatic cost reductions without impairing thruster performances (reliability was even improved). This improved thruster is today very favorably considered by several primes for small low earth orbit satellites. Hydrazine propulsion is an other example. In this field, which SEP decided in 1996 to accompany their customers in their move from large traditional satellites (SPOT/ERS family) to smaller, cheaper ones. To do so, SEP proposed a monolithic propulsion subsystem (patented design) in which all usual propulsion subsystem assembly devices (piping, supports, brackets…) are avoided, components being directly mounted on the propellant tank. Significant costs reduction could be offered to customers thanks to this innovation. Along with the hydrazine propulsion, SEP also modernised their solar array drive mechanisms the SEPTA's® — SEPTA 31 was qualified end 1998 and will have its maiden flight aboard CNES/ALCATEL JASONI small earth observation satellite. In summary, SEP had to make important changes in order to adapt to the market evolution, which occurred in the early 90's. There efforts implied as well organization as processes as products. First outputs are significant cost reduction; in line will the objectives. First hardware of this new generation will fly in year 2000.

Activity spaces among injection drug users in San Francisco.

PubMed

Martinez, Alexis N; Lorvick, Jennifer; Kral, Alex H

2014-05-01

Representations of activity spaces, defined as the local areas within which people move or travel in the course of their daily activities, are unexplored among injection drug users (IDUs). The purpose of this paper is to use an activity space framework to study place and drug user health. Data for this analysis is from an epidemiological study of street-recruited IDUs in San Francisco (N=1084). Study participants reported geographic intersections of where they most often slept at night, hung out during the day, and used drugs during a 6 month time period. We used GIS software to construct and map activity space routes of street-based network paths between these intersections. We further identified if syringe exchange program (SEP) locations intersected with, participant activity space routes. We used logistic regression to estimate associations between activity space variables and HIV serostatus, syringe sharing, and non-fatal overdose, after adjusting for individual and Census tract covariates. Mean activity space distance for all participants was 1.5miles. 9.6% of participants had a SEP located along their activity space. An increase in activity space distance was associated with a decrease in odds of being HIV positive. An increase in residential transience, or the number of different locations slept in by participants in a 6 month time period, was associated with higher odds of syringe sharing. Activity space distance was not independently associated with overdose or syringe sharing. Research that locates individuals in places of perceived importance is needed to inform placement and accessibility of HIV and overdose prevention programs. More attention needs to be given to the logistics of collecting sensitive geospatial data from vulnerable populations as well as how to maximize the use of GIS software for visualizing and understanding how IDUs interact with their environment. Copyright © 2013. Published by Elsevier B.V.

I-S/A AMPE (Inter-Service/Agency Automated Message Processing Exchange) Database Update User’s Manual.

DTIC Science & Technology

1987-03-31

I E.EF-C.-J I So-SUSSCR I SEP -RJLITI 4 1 So"-.LESC F Il BEP -TEF-r, I I So4-SIJSCR I EEP- POLUT 1 001---- 5 ISk-SUESEC PI E: I Si -SUE:-CP I EP-TEPtl...wartime) E-𔃾 r 3 Table 1;-l (cont) U Code Agency - Department of Defense DQ Central Security Service 3 DR Defense Contract Audit Agency DS Defense

Validation of an updated fractionation and indirect speciation procedure for inorganic arsenic in oxic and suboxic soils and sediments.

PubMed

Lock, Alan; Wallschläger, Dirk; McMurdo, Colin; Tyler, Laura; Belzile, Nelson; Spiers, Graeme

2016-12-01

A sequential extraction procedure (SEP) for the speciation analysis of As(III) and As(V) in oxic and suboxic soils and sediments was validated using a natural lake sediment and three certified reference materials, as well as spike recoveries of As(III) and As(V). Many of the extraction steps have been previously validated making the procedure useful for comparisons to similar previous SEP studies. The novel aspect of this research is the validation for the SEP to maintain As(III) and As(V) species. The proposed five step extraction procedure includes the extraction agents (NH 4 ) 2 SO 4 , NH 4 H 2 PO 4 , H 3 PO 4  + NH 2 OH·HCl, oxalate + ascorbic acid (heated), and HNO 3  + HCl + HF, targeting operationally defined easily exchangeable, strongly sorbed, amorphous Fe oxide bound, crystalline Fe oxide bound, and residual As fractions, respectively. The third extraction step, H 3 PO 4  + NH 2 OH·HCl, has not been previously validated for fraction selectivity. We present evidence for this extraction step to target As complexed with amorphous Fe oxides when used in the SEP proposed here. All solutions were analyzed on ICP-MS. The greatest concentrations of As were extracted from the amorphous Fe oxide fraction and the dominant species was As(V). Lake sediment materials were found to have higher As(III) concentrations than the soil materials. Because different soils/sediments have different chemical characteristics, maintenance of As species during extractions must be validated for specific soil/sediment types using spiking experiments. Copyright © 2016 Elsevier Ltd. All rights reserved.

A Smoothed Eclipse Model for Solar Electric Propulsion Trajectory Optimization

NASA Technical Reports Server (NTRS)

Aziz, Jonathan D.; Scheeres, Daniel J.; Parker, Jeffrey S.; Englander, Jacob A.

2017-01-01

Solar electric propulsion (SEP) is the dominant design option for employing low-thrust propulsion on a space mission. Spacecraft solar arrays power the SEP system but are subject to blackout periods during solar eclipse conditions. Discontinuity in power available to the spacecraft must be accounted for in trajectory optimization, but gradient-based methods require a differentiable power model. This work presents a power model that smooths the eclipse transition from total eclipse to total sunlight with a logistic function. Example trajectories are computed with differential dynamic programming, a second-order gradient-based method.

BOREAS TGB-8 Photosynthetic Rate Data over the SSA-OBS and the SSA-OJP

NASA Technical Reports Server (NTRS)

Hall, Forrest G. (Editor); Conrad, Sara K. (Editor); Lerdau, Manuel

2000-01-01

The BOREAS TGB-8 team collected data to investigate the controls over NMHC fluxes from boreal forest tree species. This data set includes measurements of photosynthetic rates at mature jack pine and black spruce sites. The data were collected at the OJP and OBS tower flux locations in the BOREAS SSA. These areas contained mature stands of jack pine and black spruce and were the focal sites in the BOREAS program for studies of biosphere/atmosphere exchange from these two habitat types. The OBS site is situated in a black spruce/sphagnum bog with the largest trees 155 years old and 10-15 m tall. The OJP site is in a jack pine forest, 80 to 120 years old, which lies on a sandy bench of glacial outwash with the largest tree standing 15 m tall. Temporally, the data cover the period of 24-May-1994 to 19-Sep-1994. The data are stored in tabular ASCII files.

BOREAS TGB-8 Starch Concentration Data Over the SSA-OBS and the SSA-OJP

NASA Technical Reports Server (NTRS)

Lerdau, Manuel; Hall, Forrest G. (Editor); Conrad, Sara K. (Editor)

2000-01-01

The BOREAS TGB-8 team collected data to investigate the controls over NMHC fluxes from boreal forest tree species. This data set includes measurements of starch concentrations in foliar samples at mature jack pine and black spruce sites. The data were collected at the OJP and OBS tower flux locations in the BOREAS SSA. These areas contained mature stands of jack pine and black spruce and were the focal sites in the BOREAS program for studies of biosphere/atmosphere exchange from these two habitat types. The OBS site is situated in a black spruce/sphagnum bog with the largest trees 155 years old and 10-15 m tall. The OJP site is in a jack pine forest, 80 to 120 years old, which lies on a sandy bench of glacial outwash with the largest tree standing 15 m tall. Temporally, the data cover the period of 24-May-1994 to 19-Sep-1994. The data are stored in tabular ASCII files.

BOREAS TGB-8 Monoterpene Concentration Data over the SSA-OBS

NASA Technical Reports Server (NTRS)

Hall, Forrest G. (Editor); Conrad, Sara K. (Editor); Lerdau, Manuel

2000-01-01

The BOREAS TGB-8 team collected data to investigate the controls over NMHC fluxes from boreal forest tree species. This data set contains measurements of monoterpene concentrations in collected foliar gas emissions and foliar samples. The data were collected at the OJP and OBS tower flux sites in the SSA and were the locus for the monoterpene emission measurements. These areas contained mature stands of jack pine and black spruce and were the focal sites in the BOREAS program for studies of biosphere/atmosphere exchange from these two habitat types. The OBS site is situated in a black spruce/sphagnum bog with the largest trees 155 years old and 10-15 m tall. The OJP site is in a jack pine forest, 80 to 120 years old, which lies on a sandy bench of glacial outwash with the largest tree standing 15 m tall. Temporally, the data cover the period of 24-May-1994 to 19-Sep-1994. The data are stored in tabular ASCII files.

Access to Sterile Injecting Equipment is More Important Than Awareness of HCV Status for Injection Risk Behaviors Among Drug Users

PubMed Central

COX, JOSEPH; MORISSETTE, CAROLE; DE, PRITHWISH; TREMBLAY, CLAUDE; ALLARD, ROBERT; GRAVES, LISA; STEPHENSON, RANDOLPH; ROY, ÉLISE

2010-01-01

Awareness of hepatitis C virus (HCV) infection status is expected to influence risk behaviors. In 2004–2005, injection drug users (IDUs) recruited from syringe exchange programs (SEPs) and methadone clinics in Montreal, Canada, were interviewed on drug use behaviors (past 6 months) and HCV testing. Subjects (n = 230) were classified as low/intermediate risk (20.4% borrowed drug preparation equipment only) and high risk (19.6% borrowed syringes), and 54.5% reported being HCV positive. Logistic regression modeling showed that compared to no risk (60% borrowed nothing), low/intermediate risk was associated with fewer noninjecting social network members, poor physical health, and problems obtaining sterile injecting equipment. High risk was associated with all of these factors except social networks. HCV status was not associated with any level of risk. Improved access to sterile injecting equipment may be more important than knowledge of HCV status in reducing injection risks among this IDU population. The study limitations are noted and recommendations discussed. PMID:19242863

Spanish as a Second Language for Elementary Students: A Study of Participation on Literacy Benchmark Scores

ERIC Educational Resources Information Center

Blackford, Kelli; Olmstead, Gwen; Stegman, Charles

2012-01-01

Student achievement in literacy and mathematics for students involved in a Spanish language program at a large and diverse school district in Arkansas, were compared to peers' scores who did not participate in the program. The program was implemented to enroll native English speaking students in a Spanish enrichment program (SEP) with the intent…

Electro-Optic Identification (EOID) Research Program

DTIC Science & Technology

2001-09-30

1 Electro - Optic Identification (EOID) Research Program Gene M. Cumm Northrop Grumman Oceanic and Naval Systems P.O. Box 1488 Annapolis...control number. 1. REPORT DATE 30 SEP 2001 2. REPORT TYPE 3. DATES COVERED 00-00-2001 to 00-00-2001 4. TITLE AND SUBTITLE Electro - Optic Identification

75 FR 15767 - Livability Initiative under Special Experimental Project No. 14

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-30

...] Livability Initiative under Special Experimental Project No. 14 AGENCY: Federal Highway Administration (FHWA... initiative to harmonize and coordinate the Federal-aid Highway Program with grant-in- aid programs... (EPA). Under this initiative, the FHWA intends to utilize Special Experimental Project No. 14 (SEP-14...

ACHP | News

Science.gov Websites

Agreement (PA) for its Weatherization Assistance Program (WAP), State Energy Program (SEP), and Energy ability of signatories to amend or terminate the agreement. DOE formally requested the ACHP comment on its , and EECBG in each state in lieu of renegotiating and amending each executed agreement. The prototype

Goddard Visiting Scientist Program for the Space and Earth Sciences Directorate

NASA Technical Reports Server (NTRS)

Kerr, Frank

1992-01-01

Progress reports of the Visiting Scientist Program covering the period from 1 Jul. - 30 Sep. 1992 are included. Topics covered include space science and earth science. Other topics covered include cosmic rays, magnetic clouds, solar wind, satellite data, high resolution radiometer, and microwave scattering.

Parent Perceptions of the Effects of the Saturday Enrichment Program on Gifted Students' Talent Development

ERIC Educational Resources Information Center

Olszewski-Kubilius, Paula; Lee, Seon-Young

2004-01-01

Based on survey responses from 187 parents of students who attended the Saturday Enrichment Program (SEP) at the Center for Talent Development (CTD) of Northwestern University, this study showed that overall, parents perceived favorable effects of the program on their children's talent development, especially academic talent development. As a…

Multi-spacecraft solar energetic particle analysis of FERMI gamma-ray flare events within the HESPERIA H2020 project

NASA Astrophysics Data System (ADS)

Tziotziou, Kostas; Malandraki, Olga; Valtonen, Eino; Heber, Bernd; Zucca, Pietro; Klein, Karl-Ludwig; Vainio, Rami; Tsiropoula, Georgia; Share, Gerald

2017-04-01

Multi-spacecraft observations of solar energetic particle (SEP) events are important for understanding the acceleration processes and the interplanetary propagation of particles released during eruptive events. In this work, we have carefully studied 25 gamma-ray flare events observed by FERMI and investigated possible associations with SEP-related events observed with STEREO and L1 spacecraft in the heliosphere. A data-driven velocity dispersion analysis (VDA) and Time-Shifting Analysis (TSA) are used for deriving the release times of protons and electrons at the Sun and for comparing them with the respective times stemming from the gamma-ray event analysis and their X-ray signatures, in an attempt to interconnect the SEPs and Fermi events and better understand the physics involved. Acknowledgements: This project has received funding from the European Union's Horizon 2020 research and innovation program under grant agreement No 637324.

Minicars research safety vehicle program. Phase 3. Volume 2. Appendices. Final report Jan 1977-Sep 1981

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ausherman, V.K.; Khadikar, A.V.; Syson, S.R.

1981-09-01

The objective of the RSV Program was to provide research and test data applicable to the automobile safety performance requirements for the mid-1980s, and to evaluate the compatibility of these requirements with environmental policies, efficient energy utilization, and consumer economic considerations.

78 FR 19490 - Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Initial Review

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-01

... DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Disease Control and Prevention Disease... announced below concerns Development of an Evidenced-- Informed Mall Walking Program Resource Guide, Special... review, discussion, and evaluation of ``Development of an Evidenced--Informed Mall Walking Program...

AS12-AS101-3 Breakthrough Capability for the NASA Astrophysics Explorer Program: Reaching the Darkest Sky

NASA Technical Reports Server (NTRS)

Greenhouse, Matthew; Benson, S.; Falck, R.; Fixsen, D.; Gardner, J.; Garvin, J.; Kruk, J.; Oleson, S.; Thronson, H.

2011-01-01

We describe a mission architecture designed to substantially increase the science capability of the NASA Science Mission Directorate (SMD) Astrophysics Explorer Program for all AO proposers working within the near-UV to far-infrared spectrum. We have demonstrated that augmentation of Falcon 9 Explorer launch services with a 13 kW Solar Electric Propulsion (SEP) stage can deliver a 700 kg science observatory payload to extra-Zodiacal orbit. Over the above wavelength range, observatory performance is limited by zodiacal light. This new capability enables up to 10X increased photometric sensitivity and 160X increased observing speed relative to a Sun-Earth L2, Earth-trailing, or Earth orbit with no increase in telescope aperture. All enabling SEP stage technologies for this launch service augmentation have reached sufficient readiness (TRl-6) for Explorer Program application in conjunction with the Falcon 9. We demonstrate that enabling Astrophysics Explorers to reach extra-zodiacal orbit will allow this small payload program to rival the Science performance of much larger long development time systems; thuS, providing a means to realize major science objectives while increasing the SMD Astrophysics portfolio diversity and resiliency to external budget pressure. The SEP technology employed in this study has strong applicability to SMD Planetary Science community-proposed missions and is a stated flight demonstration priority for NASA's Office of the Chief Technologist (OCT). This new mission architecture for astrophysics Explorers enables an attractive realization of joint goals for OCT and SMD with wide applicability across SMD science disciplines.

Functional conservation and divergence of five SEPALLATA-like genes from a basal eudicot tree, Platanus acerifolia.

PubMed

Zhang, Sisi; Lu, Shunjiao; Yi, Shuangshuang; Han, Hongji; Liu, Lei; Zhang, Jiaqi; Bao, Manzhu; Liu, Guofeng

2017-02-01

Five SEP -like genes were cloned and identified from Platanus acerifolia through the analysis of expression profiles, protein-protein interaction patterns, and transgenic phenotypes, which suggested that they play conservative and diverse functions in floral initiation and development, fruit development, bud growth, and dormancy. SEPALLATA (SEP) genes have been well characterized in core eudicots and some monocots, and they play important and diverse roles in plant development, including flower meristem initiation, floral organ identity, and fruit development and ripening. However, the knowledge on the function and evolution of SEP-like genes in basal eudicot species is very limited. Here, we cloned and identified five SEP-like genes from London plane (Platanus acerifolia), a basal eudicot tree that is widely used for landscaping in cities. Sequence alignment and phylogenetic analysis indicated that three genes (PlacSEP1.1, PlacSEP1.2, and PlacSEP1.3) belong to the SEP1/2/4 clade, while the other two genes (PlacSEP3.1 and PlacSEP3.2) are grouped into the SEP3 clade. Quantitative real-time PCR (qRT-PCR) analysis showed that all PlacSEPs, except PlacSEP1.1 and PlacSEP1.2, were expressed during the male and female inflorescence initiation, and throughout the flower and fruit development process. PlacSEP1.2 gene expression was only detected clearly in female inflorescence at April. PlacSEP1.3 and PlacSEP3.1 were also expressed, although relatively weak, in vegetative buds of adult trees. No evident PlacSEPs transcripts were detected in various organs of juvenile trees. Overexpression of PlacSEPs in Arabidopsis and tobacco plants resulted in different phenotypic alterations. 35S:PlacSEP1.1, 35S:PlacSEP1.3, and 35S:PlacSEP3.2 transgenic Arabidopsis plants showed evident early flowering, with less rosette leaves but more cauline leaves, while 35S:PlacSEP1.2 and PlacSEP3.1 transgenic plants showed no visible phenotypic changes. 35S:PlacSEP1.1 and 35S:PlacSEP3.2 transgenic Arabidopsis plants also produced smaller and curled leaves. Overexpression of PlacSEP1.1 and PlacSEP3.1 in tobacco resulted in the early flowering and producing more lateral branches. Yeast two-hybrid analysis indicated that PlacSEPs proteins can form homo- or hetero-dimers with the Platanus APETALA1 (AP1)/FRUITFULL (FUL), B-, C-, and D-class MADS-box proteins in different interacting patterns and intensities. Our results suggest that the five PlacSEP genes may play important and divergent roles during floral initiation and development, as well as fruit development, by collaborating with FUL, B-, C-, and D-class MADS-box genes in London plane; PlacSEP1.3 and PlacSEP3.1 genes might also involve in vegetative bud growth and dormancy. The results provide valuable data for us to understand the functional evolution of SEP-like genes in basal eudicot species.

Probing the Martian Exosphere and Neutral Escape Using Pickup Ions Measured by MAVEN

NASA Astrophysics Data System (ADS)

Rahmati, A.; Larson, D. E.; Cravens, T.; Halekas, J. S.; Lillis, R. J.; McFadden, J. P.; Mitchell, D. L.; Thiemann, E.; Connerney, J. E. P.; Dunn, P.; DiBraccio, G. A.; Espley, J. R.; Eparvier, F. G.; Jakosky, B. M.

2016-12-01

Soon after the MAVEN (Mars Atmosphere and Volatile EvolutioN) spacecraft started orbiting Mars in September 2014, the SEP (Solar Energetic Particle), SWIA (Solar Wind Ion Analyzer), and STATIC (Supra-Thermal and Thermal Ion Composition) instruments onboard the spacecraft started detecting planetary pickup ions. SEP can measure energetic (>50 keV) oxygen pickup ions, the source of which is the extended hot oxygen exosphere of Mars. Model results show that these pickup ions originate from tens of Martian radii upstream of Mars and are energized by the solar wind motional electric field as they gyrate back towards Mars. SEP is blind to pickup hydrogen, as the low energy threshold for detection of hydrogen in SEP is 20 keV; well above the maximum pickup hydrogen energy, which is four times the solar wind proton energy. SWIA and STATIC, on the other hand, can detect both pickup oxygen and pickup hydrogen with energies below 30 keV and created closer to Mars. During the times when MAVEN is outside the Martian bow shock and in the upstream undisturbed solar wind, the solar wind velocity measured by SWIA and the solar wind (or interplanetary) magnetic field measured by the MAG (magnetometer) instrument can be used to model pickup oxygen and hydrogen fluxes near Mars. Solar wind flux measurements of the SWIA instrument are used in calculating charge-exchange frequencies, and data from the EUVM (Extreme Ultraviolet Monitor) and SWEA (Solar Wind Electron Analyzer) instruments are also used in calculating photo-ionization and electron impact frequencies of neutral species in the Martian exosphere. By comparing SEP, SWIA, and STATIC measured pickup ion fluxes with model results, the Martian thermal hydrogen and hot oxygen neutral densities can be probed outside the bow shock, which would place constraints on estimates of oxygen and hydrogen neutral escape rates. We will present model-data comparisons of pickup ions measured outside the Martian bow shock. Our analysis reveals an order of magnitude density change with Mars season in the hydrogen exosphere, whereas the hot oxygen exosphere densities vary less than a factor of 2.

48 CFR 552.219-75 - GSA Mentor-Protégé Program.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false GSA Mentor-ProtégÃ....219-75 GSA Mentor-Protégé Program. As prescribed in 519.7017(a), insert the following clause: GSA Mentor-ProtéGé Program (SEP 2009) (a) Prime contractors, including small businesses, are encouraged to...

The HSCaRS Summer Enrichment Program; Research Opportunities for Minority and Women Undergraduates in Global Change Science

NASA Technical Reports Server (NTRS)

Estes, Jr., Maurice G.; Perkey, Donald J.; Coleman, T. L.

1997-01-01

The primary objective of the HSCaRS Summer Enrichment Program (SEP) is to make significant contributions to the NASA Mission to Planet Earth (MTPE) and the Alabama A&M University (AAMU) Center for Hydrology, Soil Climatology and Remote Sensing (HSCaRS) research missions by providing undergraduate student research internships with an emphasis on minority and women students. Additional objectives are to encourage more minority and women students to pursue advanced degrees in Earth system and global change science and to increase the participation of minority institutions in the U.S. Global Change Research Program. Also, the SEP strives to make students in the traditional science disciplines more aware of the opportunities in Earth System Science. In designing the SEP, it was acknowledged that HSCaRS was a new research effort and Center. Consequently, students were not expected to immediately recognize the Center as one would older, more established research laboratories with national reputations, such as Los Alamos, Battelle, National Consortium for Atmospheric Research (NCAR), etc. Yet we still wanted to compete nationally for the best students. Therefore, we designed the program with a competitive financial package that includes a stipend of $400 per week, round-trip transportation from home to the summer research site, and free campus housing and meal plans provided by Alabama A&M University. Students also received a modest living allowance of approximately $25 per week. The internship program was 10 weeks in residence at Alabama A&M University or IGCRE, and gave students the opportunity to select from six general research areas: micro-meteorology, soil data analysis, soil moisture modeling, instrumentation, geographic information systems, and computer science. Student participants also enrolled in an introductory global change science course as part of the summer program (a copy of the course outline is in the appendix). The program included participation in a field program for approximately two weeks. All students were required to participate in the field program as a learning experience, regardless of the relationship of the field program to their majors or particular research project.

Partial Functional Diversification of Drosophila melanogaster Septin Genes Sep2 and Sep5.

PubMed

O'Neill, Ryan S; Clark, Denise V

2016-07-07

The septin family of hetero-oligomeric complex-forming proteins can be divided into subgroups, and subgroup members are interchangeable at specific positions in the septin complex. Drosophila melanogaster has five septin genes, including the two SEPT6 subgroup members Sep2 and Sep5 We previously found that Sep2 has a unique function in oogenesis, which is not performed by Sep5 Here, we find that Sep2 is uniquely required for follicle cell encapsulation of female germline cysts, and that Sep2 and Sep5 are redundant for follicle cell proliferation. The five D. melanogaster septins localize similarly in oogenesis, including as rings flanking the germline ring canals. Pnut fails to localize in Sep5; Sep2 double mutant follicle cells, indicating that septin complexes fail to form in the absence of both Sep2 and Sep5. We also find that mutations in septins enhance the mutant phenotype of bazooka, a key component in the establishment of cell polarity, suggesting a link between septin function and cell polarity. Overall, this work suggests that Sep5 has undergone partial loss of ancestral protein function, and demonstrates redundant and unique functions of septins. Copyright © 2016 O'Neill and Clark.

Changes in chromium distribution during the electrodialytic remediation of a Cr (VI)-contaminated soil.

PubMed

Nieto Castillo, Ana M; Soriano, Juan José; García-Delgado, Rafael A

2008-04-01

A laboratory study has been carried out to determine the feasibility of in situ remediation of chromium (VI)-contaminated soil using electrodialysis in relation to its speciation in soil. This technique is best suited for low-permeability soils or sediments, which may be difficult to remediate by other means and implies the application of a low-intensity direct current to the soil, which is separated from the electrode compartments by ion-exchange membranes. A clayey soil was prepared for use in the experiments and was characterized before being mixed with a solution of potassium dichromate for several days to produce a final Cr content of 4,056 mg/kg of soil dry wt. Remediation tests were carried out under constant-voltage conditions for periods of 7-14 days and the evolution of applied current to the cell, pH, and conductivity of the electrolytes were recorded periodically. Fractionation of chromium was determined for soil samples before and after remediation using a standardized four-step sequential extraction procedure (SEP) with acetic acid, hydroxylamine, hydrogen peroxide, and aqua regia solutions. Results show that chromium is mobilized from the most labile phases (soluble/exchangeable/carbonate). In a 15 V test, SEP results show that the amount of chromium extracted in the first step drops from 80% to 9%, but also that changes in the total chromium distribution occur during the treatment with some transferred to other soil phases that are more difficult to mobilize.

RNA-Dependent Cysteine Biosynthesis in Bacteria and Archaea

DOE PAGES

Mukai, Takahito; Crnković, Ana; Umehara, Takuya; ...

2017-05-09

ABSTRACT The diversity of the genetic code systems used by microbes on earth is yet to be elucidated. It is known that certain methanogenic archaea employ an alternative system for cysteine (Cys) biosynthesis and encoding; tRNA Cysis first acylated with phosphoserine (Sep) byO-phosphoseryl-tRNA synthetase (SepRS) and then converted to Cys-tRNA Cysby Sep-tRNA:Cys-tRNA synthase (SepCysS). In this study, we searched all genomic and metagenomic protein sequence data in the Integrated Microbial Genomes (IMG) system and at the NCBI to reveal new clades of SepRS and SepCysS proteins belonging to diverse archaea in the four major groups (DPANN,Euryarchaeota, TACK, and Asgard) andmore » two groups of bacteria (“CandidatusParcubacteria” andChloroflexi). Bacterial SepRS and SepCysS charged bacterial tRNA Cysspecies with cysteinein vitro. Homologs of SepCysE, a scaffold protein facilitating SepRS-SepCysS complex assembly in Euryarchaeota class I methanogens, are found in a few groups of TACK and Asgard archaea, whereas the C-terminally truncated homologs exist fused or genetically coupled with diverse SepCysS species. Investigation of the selenocysteine (Sec)- and pyrrolysine (Pyl)-utilizing traits in SepRS-utilizing archaea and bacteria revealed that the archaea carrying full-length SepCysE employ Sec and that SepRS is often found in Pyl-utilizing archaea andChloroflexibacteria. We further discuss possible contributions of the SepRS-SepCysS system for sulfur assimilation, methanogenesis, and other metabolic processes requiring large amounts of iron-sulfur enzymes or Pyl-containing enzymes.« less

RNA-Dependent Cysteine Biosynthesis in Bacteria and Archaea

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mukai, Takahito; Crnković, Ana; Umehara, Takuya

ABSTRACT The diversity of the genetic code systems used by microbes on earth is yet to be elucidated. It is known that certain methanogenic archaea employ an alternative system for cysteine (Cys) biosynthesis and encoding; tRNA Cysis first acylated with phosphoserine (Sep) byO-phosphoseryl-tRNA synthetase (SepRS) and then converted to Cys-tRNA Cysby Sep-tRNA:Cys-tRNA synthase (SepCysS). In this study, we searched all genomic and metagenomic protein sequence data in the Integrated Microbial Genomes (IMG) system and at the NCBI to reveal new clades of SepRS and SepCysS proteins belonging to diverse archaea in the four major groups (DPANN,Euryarchaeota, TACK, and Asgard) andmore » two groups of bacteria (“CandidatusParcubacteria” andChloroflexi). Bacterial SepRS and SepCysS charged bacterial tRNA Cysspecies with cysteinein vitro. Homologs of SepCysE, a scaffold protein facilitating SepRS-SepCysS complex assembly in Euryarchaeota class I methanogens, are found in a few groups of TACK and Asgard archaea, whereas the C-terminally truncated homologs exist fused or genetically coupled with diverse SepCysS species. Investigation of the selenocysteine (Sec)- and pyrrolysine (Pyl)-utilizing traits in SepRS-utilizing archaea and bacteria revealed that the archaea carrying full-length SepCysE employ Sec and that SepRS is often found in Pyl-utilizing archaea andChloroflexibacteria. We further discuss possible contributions of the SepRS-SepCysS system for sulfur assimilation, methanogenesis, and other metabolic processes requiring large amounts of iron-sulfur enzymes or Pyl-containing enzymes.« less

The origin, and application of somatosensory evoked potentials as a neurophysiological technique to investigate neuroplasticity.

PubMed

Passmore, Steven R; Murphy, Bernadette; Lee, Timothy D

2014-06-01

Somatosensory evoked potentionals (SEPs) can be used to elucidate differences in cortical activity associated with a spinal manipulation (SM) intervention. The purpose of this narrative review is to overview the origin and application of SEPs, a neurophysiological technique to investigate neuroplasticity. Summaries of: 1) parameters for SEP generation and waveform recording; 2) SEP peak nomenclature, interpretation and generators; 3) peaks pertaining to tactile information processing (relevant to both chiropractic and other manual therapies); 4) utilization and application of SEPs; 5) SEPs concurrent with an experimental task and at baseline/control/pretest; 6) SEPs pain studies; and 7) SEPs design (pre/post) and neural reorganization/neuroplasticity; and 8) SEPs and future chiropractic research are all reviewed. Understanding what SEPs are, and their application allows chiropractors, educators, and other manual therapists interested in SM to understand the context, and importance of research findings from SM studies that involve SEPs.

Producibility in Ship Design

DTIC Science & Technology

1989-09-01

INNOVATION MARINE INDUSTRY STANDARDS WELDING INDUSTRIAL ENGINEERING EDUCATION AND TRAINING THE NATIONAL SHIPBUILDING RESEARCH PROGRAM September 1989 NSRP 0310...SEP 1989 2. REPORT TYPE N/A 3. DATES COVERED - 4. TITLE AND SUBTITLE The National Shipbuilding Research Program 1989 Ship Production Symposium...Paper No. 3: Producibility in Ship Design 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d. PROJECT NUMBER 5e

SEP-class genes in Prunus mume and their likely role in floral organ development.

PubMed

Zhou, Yuzhen; Xu, Zongda; Yong, Xue; Ahmad, Sagheer; Yang, Weiru; Cheng, Tangren; Wang, Jia; Zhang, Qixiang

2017-01-13

Flower phylogenetics and genetically controlled development have been revolutionised during the last two decades. However, some of these evolutionary aspects are still debatable. MADS-box genes are known to play essential role in specifying the floral organogenesis and differentiation in numerous model plants like Petunia hybrida, Arabidopsis thaliana and Antirrhinum majus. SEPALLATA (SEP) genes, belonging to the MADS-box gene family, are members of the ABCDE and quartet models of floral organ development and play a vital role in flower development. However, few studies of the genes in Prunus mume have yet been conducted. In this study, we cloned four PmSEPs and investigated their phylogenetic relationship with other species. Expression pattern analyses and yeast two-hybrid assays of these four genes indicated their involvement in the floral organogenesis with PmSEP4 specifically related to specification of the prolificated flowers in P. mume. It was observed that the flower meristem was specified by PmSEP1 and PmSEP4, the sepal by PmSEP1 and PmSEP4, petals by PmSEP2 and PmSEP3, stamens by PmSEP2 and PmSEP3 and pistils by PmSEP2 and PmSEP3. With the above in mind, flower development in P. mume might be due to an expression of SEP genes. Our findings can provide a foundation for further investigations of the transcriptional factors governing flower development, their molecular mechanisms and genetic basis.

Structured-Exercise-Program (SEP): An Effective Training Approach to Key Healthcare Professionals

ERIC Educational Resources Information Center

Miazi, Mosharaf H.; Hossain, Taleb; Tiroyakgosi, C.

2014-01-01

Structured exercise program is an effective approach to technology dependent resource limited healthcare area for professional training. The result of a recently conducted data analysis revealed this. The aim of the study is to know the effectiveness of the applied approach that was designed to observe the level of adherence to newly adopted…

BOREAS TE-5 Soil Respiration Data

NASA Technical Reports Server (NTRS)

Hall, Forrest G. (Editor); Curd, Shelaine (Editor); Ehleriinger, Jim; Brooks, J. Renee; Flanagan, Larry

2000-01-01

The BOREAS TE-5 team collected measurements in the NSA and SSA on gas exchange, gas composition, and tree growth. Soil respiration data were collected from 26-May-94 to 07-Sep-94 in the BOREAS NSA and SSA to compare the soil respiration rates in different forest sites using a LI-COR 6200 soil respiration chamber (model 6299). The data are stored in tabular ASCII files. The data files are available on a CD-ROM (see document number 20010000884), or from the Oak Ridge National Laboratory (ORNL) Distrobuted Activity Archive Center (DAAC).

Postnatal treatment with metyrapone attenuates the effects of diet-induced obesity in female rats exposed to early-life stress.

PubMed

Murphy, Margaret O; Herald, Joseph B; Wills, Caleb T; Unfried, Stanley G; Cohn, Dianne M; Loria, Analia S

2017-02-01

Experimental studies in rodents have shown that females are more susceptible to exhibiting fat expansion and metabolic disease compared with males in several models of fetal programming. This study tested the hypothesis that female rat pups exposed to maternal separation (MatSep), a model of early-life stress, display an exacerbated response to diet-induced obesity compared with male rats. Also, we tested whether the postnatal treatment with metyrapone (MTP), a corticosterone synthase inhibitor, would attenuate this phenotype. MatSep was performed in WKY offspring by separation from the dam (3 h/day, postnatal days 2-14). Upon weaning, male and female rats were placed on a normal (ND; 18% kcal fat) or high-fat diet (HFD; 60% kcal fat). Nondisturbed littermates served as controls. In male rats, no diet-induced differences in body weight (BW), glucose tolerance, and fat tissue weight and morphology were found between MatSep and control male rats. However, female MatSep rats displayed increased BW gain, fat pad weights, and glucose intolerance compared with control rats (P < 0.05). Also, HFD increased plasma corticosterone (196 ± 51 vs. 79 ± 18 pg/ml, P < 0.05) and leptin levels (1.8 ± 0.4 vs. 1.3 ± 0.1 ng/ml, P < 0.05) in female MatSep compared with control rats, whereas insulin and adiponectin levels were similar between groups. Female control and MatSep offspring were treated with MTP (50 µg/g ip) 30 min before the daily separation. MTP treatment significantly attenuated diet-induced obesity risk factors, including elevated adiposity, hyperleptinemia, and glucose intolerance. These findings show that exposure to stress hormones during early life could be a key event to enhance diet-induced obesity and metabolic disease in female rats. Thus, pharmacological and/or behavioral inflection of the stress levels is a potential therapeutic approach for prevention of early life stress-enhanced obesity and metabolic disease. Copyright © 2017 the American Physiological Society.

Flower development of Phalaenopsis orchid involves functionally divergent SEPALLATA-like genes

PubMed Central

Pan, Zhao-Jun; Chen, You-Yi; Du, Jian-Syun; Chen, Yun-Yu; Chung, Mei-Chu; Tsai, Wen-Chieh; Wang, Chun-Neng; Chen, Hong-Hwa

2014-01-01

The Phalaenopsis orchid produces complex flowers that are commercially valuable, which has promoted the study of its flower development. E-class MADS-box genes, SEPALLATA (SEP), combined with B-, C- and D-class MADS-box genes, are involved in various aspects of plant development, such as floral meristem determination, organ identity, fruit maturation, seed formation and plant architecture. Four SEP-like genes were cloned from Phalaenopsis orchid, and the duplicated PeSEPs were grouped into PeSEP1/3 and PeSEP2/4. All PeSEPs were expressed in all floral organs. PeSEP2 expression was detectable in vegetative tissues. The study of protein–protein interactions suggested that PeSEPs may form higher order complexes with the B-, C-, D-class and AGAMOUS LIKE6-related MADS-box proteins to determine floral organ identity. The tepal became a leaf-like organ when PeSEP3 was silenced by virus-induced silencing, with alterations in epidermis identity and contents of anthocyanin and chlorophyll. Silencing of PeSEP2 had minor effects on the floral phenotype. Silencing of the E-class genes PeSEP2 and PeSEP3 resulted in the downregulation of B-class PeMADS2-6 genes, which indicates an association of PeSEP functions and B-class gene expression. These findings reveal the important roles of PeSEP in Phalaenopsis floral organ formation throughout the developmental process by the formation of various multiple protein complexes. PMID:24571782

SEPS mission and system integration/interface requirements for the space transportation system. [Solar Electric Propulsion System

NASA Technical Reports Server (NTRS)

Cork, M. J.; Barnett, P. M.; Shaffer, J., Jr.; Doran, B. J.

1979-01-01

Earth escape mission requirements on Solar Electric Propulsion System (SEPS), and the interface definition and planned integration between SEPS, user spacecraft, and other elements of the STS. Emphasis is placed on the Comet rendezvous mission, scheduled to be the first SEPS user. Interactive SEPS interface characteristics with spacecraft and mission, as well as the multiple organizations and inter-related development schedules required to integrate the SEPS with spacecraft and STS, require early attention to definition of interfaces in order to assure a successful path to the first SEPS launch in July 1985

Does the threshold for reporting musculoskeletal pain or the probability of attributing work-relatedness vary by socioeconomic position or sex?

PubMed

Mehlum, Ingrid Sivesind; Kristensen, Petter; Veiersted, Kaj Bo; Wærsted, Morten; Punnett, Laura

2013-08-01

To examine the effect of sex and socioeconomic position (SEP) on individuals' perceptions of pain and its work-relatedness. We compared self-reported pain in neck-shoulder or arm with clinical diagnoses and workers' judgments of work-relatedness with physicians' assessments based on specific criteria, between sexes and high- and low-SEP participants in the Oslo Health Study (n = 217). Clinical diagnoses were more frequent in low-SEP subjects than high-SEP subjects with pain and generally higher in women than in men. Pain attributed to work was more frequently assessed as work-related by the physicians in low-SEP subjects than high-SEP subjects and in men than in women of low SEP. The threshold for reporting pain seemed higher in low-SEP subjects and among women. Physicians were more likely to agree with low-SEP workers about work-relatedness.

NPS TINYSCOPE Program Management

DTIC Science & Technology

2010-09-01

SMDC - Space and Missile Defense Command SOW - Statement of Work STEM - Science, Technology, Engineering and Mathematics STP - Space Test Program...the project. A statement of work ( SOW ) is typically used to document broad responsibilities, deliverables, and the work activities required in a...given project. The SOW acts as a guideline Summary of TINYSCOPE and Argus Requirements Requirement Threshold Objective Mission IOC Sep 2011 ASAP

Supporting Secure, AD HOC Joins for Tactical Networks

DTIC Science & Technology

2002-05-07

ftp.isi.edu/in-notes/ rfc2501.txt (20SEP01). [4] Deitel , Harvery M. and Paul J. Deitel . Java: How to Program 3rd Edition. (Prentice Hall: New...produce a complete product, to include the construction of TTNT hardware. The TTNT program is concerned with frequency hopping schemes, error correcting...Configuration To create the digital certificates needed for the client authentication, we modified a hybrid file encryption program that used a Rivest-Shamir

Navy Occupational Health Information Management System (NOHIMS). System-Wide Module. Program Maintenance Manual

DTIC Science & Technology

1987-06-01

NAVY OCCUPATIONAL HEALTH INFORMATION MANAGEMENT SYSTEM NOHIMS SYSTEM-WIDE MODULE PROGRAM MAINTENANCE MANUAL JUNE 1987 DTIC 00 SEP I 21988DJ 0) 4... INFORMATION MANAGEMENT SYSTEM (NOHIMS) N 1.98 SYSTEM-WIDE MODULE PROGRAM MAINTENANCE MANUAL 7. Author(s) a. Performing Organization Rapt. No. MITRE... Management System (NOHIMS). NORIMS, whose initial version was ,eveloped at the Naval Health Research Center (NHRC), is a composite of 4 -’o subsystems: an

GENERAL ENVIRONMENTAL CORPORATION; CURE ELECTROCOAGULATION TECHNOLOGY: INNOVATIVE TECHNOLOGY EVALUATION REPORT

EPA Science Inventory

The CURE electrocoagulation technology was demonstrated under the Superfund Innovative Technology Evaluation (SITE) program at the U.S. Department of Energy (DOE) Rocky Flats Environmental Technology Site (RFETS), where water from the solar evaporation ponds (SEPs) was contaminat...

Systematic Evaluation Program (SEP) at Rocky Flats Plant: An overview of practical management issues for evaluation of natural phenomena hazards

DOE Office of Scientific and Technical Information (OSTI.GOV)

Badwan, F.M.; Herring, K.S.

1993-08-01

Many of the buildings at the Rocky Flats Plant were designed and built before modern standards were developed, including standards for protection against extreme natural phenomenon such as tornadoes, earthquakes, and floods. The purpose of the SEP is to establish an integrated approach to assessing the design adequacy of specific high and moderate hazard Rocky Flats facilities from a safety perspective and to establish a basis for defining any needed facility improvements. The SEP is to be carried out in three Phases. In Phase 1, topics to be evaluated and an evaluation plan for each topic were developed. Any differencesmore » between Current Design Requirements (CDR) or acceptance criteria and the design of existing facilities, will be identified during Phase 2 and assessed using an integrated systematic approach during Phase 3. The integrated assessment performed during Phase 3 provides a process for evaluating the differences between existing facility design and CDRs so that decisions on corrective actions can be made on the basis of relative risk reduction and cost effectiveness. These efforts will ensure that a balanced and integrated level of safety is achieved for long-term operation of these buildings. Through appropriate selection of topics and identification of the structures, systems, and components to be evaluated, the SEP will address outstanding design issues related to the prevention and mitigation of design basis accidents, including those arising from natural phenomena. The objective of the SEP is not to bring these buildings into strict compliance with current requirements, but rather to ensure that an adequate level of safety is achieved in an economical fashion.« less

Pornography, Sexual Enhancement Products, and Sexual Risk of Female Sex Workers and their Clients in Southern India.

PubMed

Bradley, Janet; Rajaram, Subramanian Potty; Isac, Shajy; Gurav, Kaveri; Ramesh, B M; Gowda, Chandrashekhar; Moses, Stephen; Alary, Michel

2016-05-01

Despite their large numbers, and important role in the HIV epidemic in India, male clients of female sex workers (FSWs) are a difficult to reach population and little is known about their sexual behaviors. Using data from an integrated behavioral and biological assessment of 684 clients in Bangalore in 2012, we examined factors associated with their reports of having sex with three or more different female sex workers in the last month, and anal sex with sex workers. We included sociodemographic and sexual behavior factors and, for the first time in client studies in India, included data on the use of pornography and sexual enhancement products (SEPs) such as pills, oils, and sprays, in our multivariable analyses of client risk. Seventy-eight percent of clients had seen pornographic material and 8% reported ever having used SEPs. The profiles of men practicing the two risk behaviors examined were quite different. Travel in the past year, drunkenness in the past month, young age at first commercial sex, non-use of condoms at last sex, and finding sex workers in public places (but not use of pornography and SEPs) were independently associated with multiple partnering. Sex with a man or transsexual, being a white collar worker, seeking out FSWs at home, pornography and SEP use, and condom use at last FSW sex, were all independently associated with anal sex with an FSW. More research is needed to better understand the links between pornography and SEPs, and HIV risk behaviors, and HIV prevention programs need to be cognizant of the importance of ensuring that condom use is adequately promoted and supported in the context of anal sex in female sex worker-client interactions.

Differentiation of direct and indirect socioeconomic effects on suicide attempts in South Korea

PubMed Central

Ki, Myung; Seong Sohn, Eui; An, Byungduck; Lim, Jiseun

2017-01-01

Abstract Despite the wide recognition of the inverse association between socioeconomic position (SEP) and suicidal behaviors, its underlying process and potential mediators are little known. This study investigated the pathway from SEP to suicide attempts with attention to potential mediators. From the Korean Health and Nutrition Examination Survey 2007–2013, which is a nationwide cross-sectional survey of the health and nutritional status, a total of 34,565 participants (≥30 years) were included in the analysis. To unfold the pathways linking SEP to suicide attempts, the direct and indirect effects of 3 SEP measures (educational attainment, household income, and occupational group) and 3 mediators (physical illness, mental health problems, and problematic drinking) were differentiated using structured equation model (SEM). Most of direct and indirect effects of educational attainment, household income, and occupational group on suicide attempts were significant; Nonemployment status had the largest total (β = 0.291, P < .01) and direct effects (β = 0.212, P < .01), while educational attainment had the largest indirect effect (β = −0.124, P < .01). Educational attainment was mainly mediated by physical illness and problem drinking, whereas household income and occupational group were mainly mediated by anxious or depressed mood and problem drinking. Physical illness played a major role in explaining suicide attempts, compared to mental health problem and problem drinking. Overall, experience of socioeconomic disadvantage increased suicide attempts independently of mental and physical problems. An extension of suicide prevention program is required for comprehensively targeting people with general problems such as physical illness and low SEP, complemented to narrowly targeting high risk group with, such as mental health problem. PMID:29390510

Great SEP events and space weather: 1. Experience of automatically searching for event beginnings; probabilities of false and missed events

NASA Astrophysics Data System (ADS)

Applbaum, David; Dorman, Lev; Pustil'Nik, Lev; Sternlieb, Abraham; Zagnetko, Alexander; Zukerman, Igor

It is well known that during great SEP events, fluxes of energetic particles can be so big that the memory of computers and other electronics in space may be destroyed, and satellites and spacecraft may cease to function. According to the NOAA Space Weather Prediction Cen-ter, the following scales constitute dangerous solar radiation storms: S5-extreme (flux level of particles with energy ∼ 10 MeV more than 105 ); S4 - severe(f luxmorethan104 ); andS3 - strong(f luxmorethan103 ). In these persiods, it is necessary to switch off some of the electronics for a few hours energy particles (meaning those with a few GeV/nucleon and higher), whose transportation to Earthfrom the S20 minutes after they accelerate and escape into the solar wind) than the main bulk of the smaller energy particle 60 minutes later). Here we describe the principles and experience of the automatic function of the "SEP - Search" program. The positive result, showing the exact beginning of an SEP event on the Emilio Segre Observ 10.8GV ), is determined now automatically by simultaneously increasing by 2.5 St.Dev. in two sections of the ne search "programnext uses 1-mindata for checking whether or not the observed increase reflects the beginning Research "automatically starts to work online. We determine also the probabilities of false and missed alerts.

BOREAS TE-9 In Situ Diurnal Gas Exchange of NAS Boreal Forest Stands

NASA Technical Reports Server (NTRS)

Hall, Forrest G. (Editor); Curd, Shelaine (Editor); Margolis, Hank; Coyea, Marie; Dang, Qinglai

2000-01-01

The BOREAS TE-9 team collected several data sets related to chemical and photosynthetic properties of leaves in boreal forest tree species. The purpose of the BOREAS TE-09 study was threefold: 1) to provide in situ gas exchange data that will be used to validate models of photosynthetic responses to light, temperature, and carbon dioxide (CO2); 2) to compare the photosynthetic responses of different tree crown levels (upper and lower); and 3) to characterize the diurnal water potential curves for these sites to get an indication of the extent to which soil moisture supply to leaves might be limiting photosynthesis. The gas exchange data of the BOREAS NSA were collected to characterize diurnal gas exchange and water potential of two canopy levels of five boreal canopy cover types: young jack pine, old jack pine, old aspen, lowland old black spruce, and upland black spruce. These data were collected between 27-May-1994 and 17-Sep-1994. The data are provided in tabular ASCII files. The data files are available on a CD-ROM (see document number 20010000884), or from the Oak Ridge National Laboratory (ORNL) Distributed Active Archive Center (DAAC).

The National Shipbuilding Research Program. 1989 Ship Production Symposium. Paper No. 3: Producibility in Ship Design

DTIC Science & Technology

1989-09-01

INNOVATION MARINE INDUSTRY STANDARDS WELDING INDUSTRIAL ENGINEERING EDUCATION AND TRAINING THE NATIONAL SHIPBUILDING RESEARCH PROGRAM September 1989 NSRP 0310...SEP 1989 2. REPORT TYPE 3. DATES COVERED 00-00-1989 to 00-00-1989 4. TITLE AND SUBTITLE The National Shipbuilding Research Program . 1989 Ship...Production Symposium, Paper No. 3: Producibility in Ship Design 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d

Can somatosensory and visual evoked potentials predict neurological outcome during targeted temperature management in post cardiac arrest patients?

PubMed

Choi, Seung Pill; Park, Kyu Nam; Wee, Jung Hee; Park, Jeong Ho; Youn, Chun Song; Kim, Han Joon; Oh, Sang Hoon; Oh, Yoon Sang; Kim, Soo Hyun; Oh, Joo Suk

2017-10-01

In cardiac arrest patients treated with targeted temperature management (TTM), it is not certain if somatosensory evoked potentials (SEPs) and visual evoked potentials (VEPs) can predict neurological outcomes during TTM. The aim of this study was to investigate the prognostic value of SEPs and VEPs during TTM and after rewarming. This retrospective cohort study included comatose patients resuscitated from cardiac arrest and treated with TTM between March 2007 and July 2015. SEPs and VEPs were recorded during TTM and after rewarming in these patients. Neurological outcome was assessed at discharge by the Cerebral Performance Category (CPC) Scale. In total, 115 patients were included. A total of 175 SEPs and 150 VEPs were performed. Five SEPs during treated with TTM and nine SEPs after rewarming were excluded from outcome prediction by SEPs due to an indeterminable N20 response because of technical error. Using 80 SEPs and 85 VEPs during treated with TTM, absent SEPs yielded a sensitivity of 58% and a specificity of 100% for poor outcome (CPC 3-5), and absent VEPs predicted poor neurological outcome with a sensitivity of 44% and a specificity of 96%. The AUC of combination of SEPs and VEPs was superior to either test alone (0.788 for absent SEPs and 0.713 for absent VEPs compared with 0.838 for the combination). After rewarming, absent SEPs and absent VEPs predicted poor neurological outcome with a specificity of 100%. When SEPs and VEPs were combined, VEPs slightly increased the prognostic accuracy of SEPs alone. Although one patient with absent VEP during treated with TTM had a good neurological outcome, none of the patients with good neurological outcome had an absent VEP after rewarming. Absent SEPs could predict poor neurological outcome during TTM as well as after rewarming. Absent VEPs may predict poor neurological outcome in both periods and VEPs may provide additional prognostic value in outcome prediction. Copyright © 2017 Elsevier B.V. All rights reserved.

Annual Tropical Cyclone Report, 1982.

DTIC Science & Technology

1982-01-01

intensity forecast are made once each day by processed at AFGWC is recorded on-board applying the Dvorak technique (NOAA Technical the spacecraft as it...tropical cyclone. Season totals and the 700 mb pressure surface within the percentages are also indicated. vortex recorded in meters. 7 Z ;l__...16 TY GORDON 27 AUG - 5 SEP 10 39 100 944 2014 17 TS HOPE 4 SEP - 6 SEP 3 10 #0 979 630 18 TY IRVING 5 SEP - 16 SEP 12 44 90 952 1770 19 TY JUDY 5 SEP

Functional Analysis of BcBem1 and Its Interaction Partners in Botrytis cinerea: Impact on Differentiation and Virulence

PubMed Central

Schumacher, Julia; Kokkelink, Leonie; Tudzynski, Paul

2014-01-01

In phytopathogenic fungi the establishment and maintenance of polarity is not only essential for vegetative growth and differentiation, but also for penetration and colonization of host tissues. We investigated orthologs of members of the yeast polarity complex in the grey mould fungus Botrytis cinerea: the scaffold proteins Bem1 and Far1, the GEF (guanine nucleotide exchange factor) Cdc24, and the formin Bni1 (named Sep1 in B. cinerea). BcBem1 does not play an important role in regular hyphal growth, but has significant impact on spore formation and germination, on the establishment of conidial anastomosis tubes (CATs) and on virulence. As in other fungi, BcBem1 interacts with the GEF BcCdc24 and the formin BcSep1, indicating that in B. cinerea the apical complex has a similar structure as in yeast. A functional analysis of BcCdc24 suggests that it is essential for growth, since it was not possible to obtain homokaryotic deletion mutants. Heterokaryons of Δcdc24 (supposed to exhibit reduced bccdc24 transcript levels) already show a strong phenotype: an inability to penetrate the host tissue, a significantly reduced growth rate and malformation of conidia, which tend to burst as observed for Δbcbem1. Also the formin BcSep1 has significant impact on hyphal growth and development, whereas the role of the putative ortholog of the yeast scaffold protein Far1 remains open: Δbcfar1 mutants have no obvious phenotypes. PMID:24797931

Life-course socioeconomic position and hypertension in African American men: the Pitt County Study.

PubMed

James, Sherman A; Van Hoewyk, John; Belli, Robert F; Strogatz, David S; Williams, David R; Raghunathan, Trevillore E

2006-05-01

We investigated the odds of hypertension for Black men in relationship to their socioeconomic position (SEP) in both childhood and adulthood. On the basis of their parents' occupation, we classified 379 men in the Pitt County (North Carolina) Study into low and high childhood SEP. The men's own education, occupation, employment status, and home ownership status were used to classify them into low and high adulthood SEP. Four life-course SEP categories resulted: low childhood/low adulthood, low childhood/high adulthood, high childhood/low adulthood, and high childhood/high adulthood. Low childhood SEP was associated with a 60% greater odds of hypertension, and low adulthood SEP was associated with a 2-fold greater odds of hypertension. Compared with men of high SEP in both childhood and adulthood, the odds of hypertension were 7 times greater for low/low SEP men, 4 times greater for low/high SEP men, and 6 times greater for high/low SEP men. Greater access to material resources in both childhood and adulthood was protective against premature hypertension in this cohort of Black men. Though some parameter estimates were imprecise, study findings are consistent with both pathway and cumulative burden models of hypertension.

Relationship between SEP Peak intensity and CME Acceleration, Speed and Width

NASA Astrophysics Data System (ADS)

Xie, H.; St Cyr, O. C.; Makela, P. A.; Gopalswamy, N.

2017-12-01

We study the large solar energetic particle (SEP) events that were detected by GOES in the >10 MeV energy channel during December 2006 to January 2016. Data used in this study includes the Solar Electron Proton Telescope (SEPT) and High Energy Telescopes (HET) on STEREO A and B, the Electron, Proton, and Alpha Monitor (EPAM) on ACE, and the Energetic and Relativistic Nuclei and Electron instrument (ERNE) on SOHO. By choosing the smallest connection angles between SEP solar locations and magnetic foot-points of each spacecraft, we divide SEP events as SOHO SEPs or STEREO SEPs. We then compute the SEP peak intensity I0 at the center of the Gausssian using the Gausssian expression from Richardson et al. (2014) and study the relationship between SEP electron and proton peak intensity and CME acceleration, speed and width. By using I0 derived from multi-spacecraft observations we found that the correlations between SEP peak intensity and CME acceleration and speed improved. We also found that this correlation can be further improved by taking into account the effects of CME width and its solar source latitude. The implication for the SEP forecast of our obtained results will be discussed.

Life course socioeconomic conditions, adulthood risk factors and cardiovascular mortality among men and women: a 17-year follow up of the GLOBE study.

PubMed

Kamphuis, Carlijn B M; Turrell, Gavin; Giskes, Katrina; Mackenbach, Johan P; van Lenthe, Frank J

2013-10-03

Our goal was to study associations between childhood socioeconomic position (SEP), adulthood SEP, adulthood risk factors and cardiovascular disease (CVD) mortality, by investigating the critical period and pathway models. The prospective GLOBE study in the Netherlands, with baseline data from 1991, was linked with cause of death register data from Statistics Netherlands in 2007. At baseline, respondents reported information on childhood SEP (i.e. occupational level of respondent's father), adulthood SEP (educational level), and adulthood risk factors (health behaviours, material circumstances, and psychosocial factors). Analyses included 4894 men and 5572 women. Data were analysed by Cox proportional hazard ratios (HR) with CVD mortality as the outcome. Childhood SEP was associated with CVD mortality among men with the lowest childhood SEP only (HR 1.32, 95% CI 1.00-1.74), and not among women. The majority of childhood SEP inequalities in CVD mortality among men (88%) were explained by material, behavioural and psychosocial risk factors in adulthood, and adulthood SEP. This was mostly due to the association of childhood SEP with adulthood SEP, and the interrelations of adulthood SEP with risk factors, and partly via the direct association of childhood SEP with adulthood risk factors, independent of adulthood SEP. This study supports the pathway model for men, but found no evidence that socioeconomic conditions in childhood are critical for CVD mortality in later life independent of adulthood conditions. Developing effective methods to reduce material and behavioural risk factors among lower socioeconomic groups should be a top priority in cardiovascular disease prevention. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

Social influences on health-related behaviour clustering during adulthood in two British birth cohort studies.

PubMed

Mawditt, Claire; Sacker, Amanda; Britton, Annie; Kelly, Yvonne; Cable, Noriko

2018-05-01

Building upon evidence linking socio-economic position (SEP) in childhood and adulthood with health-related behaviours (HRB) in adulthood, we examined how pre-adolescent SEP predicted membership of three HRB clusters: "Risky", "Moderate Smokers" and "Mainstream" (the latter pattern consisting of more beneficial HRBs), that were detected in our previous work. Data were taken from two British cohorts (born in 1958 and 1970) in pre-adolescence (age 11 and 10, respectively) and adulthood (age 33 and 34). SEP constructs in pre-adolescence and adulthood were derived through Confirmatory Factor Analysis. Conceptualised paths from pre-adolescent SEP to HRB cluster membership via adult SEP in our path models were tested for statistical significance separately by gender and cohort. Adult SEP mediated the path between pre-adolescent SEP and adult HRB clusters. More disadvantaged SEP in pre-adolescence predicted more disadvantaged SEP in adulthood which was associated with membership of the "Risky" and "Moderate Smokers" clusters compared to the "Mainstream" cluster. For example, large positive indirect effects between pre-adolescent SEP and adult HRB via adult SEP were present (coefficient 1958 Women = 0.39; 1970 Women = 0.36, 1958 Men = 0.51; 1970 Men = 0.39; p < 0.01) when comparing "Risky" and "Mainstream" cluster membership. Amongst men we found a small significant direct association (p < 0.001) between pre-adolescent SEP and HRB cluster membership. Our findings suggest that associations between adult SEP and HRBs are not likely to be pre-determined by earlier social circumstances, providing optimism for interventions relevant to reducing social gradients in HRBs. Observing consistent findings across the cohorts implies the social patterning of adult lifestyles may persist across time. Copyright © 2018 The Authors. Published by Elsevier Inc. All rights reserved.

Highlights in the History of the Army Nurse Corps

DTIC Science & Technology

1981-01-01

group members in Army Nurse Corps recruitment programs. Sep 1972 A Nurse- Midwifery Service, the first such separate service, was started at Ireland...director of a second Nurse- Midwifery Service.) 1Mar 1973 Lt. Col. Geraldene Felton, Ed. D., ANC, Lt. Col. Phyllis Verhonick, Ed. D., USA (Ret.), and Lt...Kentucky Nurse- Midwifery Program, a graduate program which combined the university’s academic instruction and the Army’s clinical facilities. In May 1975

A Reduction in Selenoprotein S Amplifies the Inflammatory Profile of Fast-Twitch Skeletal Muscle in the mdx Dystrophic Mouse.

PubMed

Wright, Craig Robert; Allsopp, Giselle Larissa; Addinsall, Alex Bernard; McRae, Natasha Lee; Andrikopoulos, Sofianos; Stupka, Nicole

2017-01-01

Excessive inflammation is a hallmark of muscle myopathies, including Duchenne muscular dystrophy (DMD). There is interest in characterising novel genes that regulate inflammation due to their potential to modify disease progression. Gene polymorphisms in Selenoprotein S ( Seps1 ) are associated with elevated proinflammatory cytokines, and in vitro SEPS1 is protective against inflammatory stress. Given that SEPS1 is highly expressed in skeletal muscle, we investigated whether the genetic reduction of Seps1 exacerbated inflammation in the mdx mouse. F1 male mdx mice with a heterozygous Seps1 deletion ( mdx : Seps1 -/+ ) were generated. The mdx:Seps1 -/+ mice had a 50% reduction in SEPS1 protein expression in hindlimb muscles. In the extensor digitorum longus (EDL) muscles, mRNA expression of monocyte chemoattractant protein 1 ( Mcp-1 ) ( P = 0.034), macrophage marker F4/80 ( P = 0.030), and transforming growth factor-β1 ( Tgf-β1 ) ( P = 0.056) were increased in mdx:Seps1 -/+ mice. This was associated with a reduction in muscle fibre size; however, ex vivo EDL muscle strength and endurance were unaltered. In dystrophic slow twitch soleus muscles, SEPS1 reduction had no effect on the inflammatory profile nor function. In conclusion, the genetic reduction of Seps1 appears to specifically exacerbate the inflammatory profile of fast-twitch muscle fibres, which are typically more vulnerable to degeneration in dystrophy.

Roles of the 15-kDa Selenoprotein (Sep15) in Redox Homeostasis and Cataract Development Revealed by the Analysis of Sep 15 Knockout Mice*

PubMed Central

Kasaikina, Marina V.; Fomenko, Dmitri E.; Labunskyy, Vyacheslav M.; Lachke, Salil A.; Qiu, Wenya; Moncaster, Juliet A.; Zhang, Jie; Wojnarowicz, Mark W.; Natarajan, Sathish Kumar; Malinouski, Mikalai; Schweizer, Ulrich; Tsuji, Petra A.; Carlson, Bradley A.; Maas, Richard L.; Lou, Marjorie F.; Goldstein, Lee E.; Hatfield, Dolph L.; Gladyshev, Vadim N.

2011-01-01

The 15-kDa selenoprotein (Sep15) is a thioredoxin-like, endoplasmic reticulum-resident protein involved in the quality control of glycoprotein folding through its interaction with UDP-glucose:glycoprotein glucosyltransferase. Expression of Sep15 is regulated by dietary selenium and the unfolded protein response, but its specific function is not known. In this study, we developed and characterized Sep15 KO mice by targeted removal of exon 2 of the Sep15 gene coding for the cysteine-rich UDP-glucose:glycoprotein glucosyltransferase-binding domain. These KO mice synthesized a mutant mRNA, but the shortened protein product could be detected neither in tissues nor in Sep15 KO embryonic fibroblasts. Sep15 KO mice were viable and fertile, showed normal brain morphology, and did not activate endoplasmic reticulum stress pathways. However, parameters of oxidative stress were elevated in the livers of these mice. We found that Sep15 mRNA was enriched during lens development. Further phenotypic characterization of Sep15 KO mice revealed a prominent nuclear cataract that developed at an early age. These cataracts did not appear to be associated with severe oxidative stress or glucose dysregulation. We suggest that the cataracts resulted from an improper folding status of lens proteins caused by Sep15 deficiency. PMID:21768092

LCRE and SNAP 50-DR-1 programs. Engineering progress report, October 1, 1962--December 31, 1962

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

Declassified 5 Sep 1973. Information is presented concerning LCRE specifications, reactor kinetics, fuel elements, primary coolant circuit, secondary coolant circuit, materials development, and fabrication; and SNAP50-DR- 1 specifications, primary pump, and materials development. (DCC)

LCRE and SNAP 50-DR-1 programs. Engineering progress report, January 1, 1963--March 31, 1963

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

Declassified 5 Sep 1973. Information is presented concerning LCRE specifications, primary coolant circuit, aaxiliary systems, fuel elements, instrumentation, materials development, and fabrication; and SNAP-50DR-1 specifications, fuel elements, pumps, steam generator, and materials development. (DCC)

75 FR 30040 - Disease, Disability, and Injury Prevention and Control

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-28

... DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Disease Control and Prevention Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Member Conflict Review, Program... Act (Pub. L. 92-463), the Centers for Disease Control and Prevention (CDC) announces the...

75 FR 34750 - Disease, Disability, and Injury Prevention and Control

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-18

... DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Disease Control and Prevention Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Cooperative Agreement Program for... Committee Act (Pub. L. 92-463), the Centers for Disease Control and Prevention (CDC) announces the...

Space Weather at Mars: MAVEN and MSL/RAD Observations of CME and SEP Events

NASA Astrophysics Data System (ADS)

Lee, C. O.; Ehresmann, B.; Lillis, R. J.; Dunn, P.; Rahmati, A.; Larson, D. E.; Guo, J.; Zeitlin, C.; Luhmann, J. G.; Halekas, J. S.; Espley, J. R.; Thiemann, E.; Hassler, D.

2017-12-01

While MAVEN have been observing the space weather conditions driven by ICMEs and SEPs in orbit around Mars, MSL/RAD have been measuring the surface radiation environment due to E > 150 MeV/nuc SEPs and the higher-energy galactic cosmic rays. The suite of MAVEN instruments measuring the particles (SEP), plasma (SWIA) and fields (MAG) information provides detailed local space weather information regarding the solar activity-related fluctuations in the measured surface dose rates. At the same time, the related enhancements in the RAD surface dose rates indicate the degree to which the SEPs affect the lower atmosphere and surface. We will present an overview of the MAVEN observations together with the MSL/RAD measurements and focus our discussion on a number of space weather events driven by CMEs and SEPs. During the March 2015 solar storm period, a succession of CMEs produced intense SEP proton fluxes that were detected by MAVEN/SEP in the 20 keV to 6 MeV detected energy channels. At higher energies, MAVEN/SEP record `FTO' SEP events that were triggered by > 13 MeV energetic protons passing through all three silicon detector layers (Front, Thick, and Open). Using the detector response matrix for an FTO event (incident energy vs detected energy), the minimum incident energy of the SEP protons observed in March 2015 was inferred to be > 40 MeV. The lack of any notable enhancements in the surface dose rate by MSL/RAD suggests that the highest incident energies of the SEP protons were < 150 MeV. Note that Forbush-like decreases were observed due to the local passages of the ICMEs. In contrast, MSL/RAD detected dose rate enhancements above the background level in October 2015 even though the MAVEN SWIA and MAG instruments did not detect any local passage of an ICME nor did the SEP instrument observe any SEP proton fluxes in the 20 keV to 6 MeV energy channels. However, MAVEN/SEP did record an FTO event that coincided with the RAD dose rate enhancement, all of which suggest that > 150 MeV SEP protons impacted the Martian atmosphere and surface. The source of the October 2015 SEP event was probably the CME that erupted near the solar west limb with respect to the Sun-Mars line. As part of the discussion, we will also show solar-heliospheric observations from near-Earth assets together with WSA-Enlil-cone results for some global heliospheric context.

Using a centralised database system and server in the European Union Framework Programme 7 project SEPServer

NASA Astrophysics Data System (ADS)

Heynderickx, Daniel

2012-07-01

The main objective of the SEPServer project (EU FP7 project 262773) is to produce a new tool, which greatly facilitates the investigation of solar energetic particles (SEPs) and their origin: a server providing SEP data, related electromagnetic (EM) observations and analysis methods, a comprehensive catalogue of the observed SEP events, and educational/outreach material on solar eruptions. The project is coordinated by the University of Helsinki. The project will combine data and knowledge from 11 European partners and several collaborating parties from Europe and US. The datasets provided by the consortium partners are collected in a MySQL database (using the ESA Open Data Interface under licence) on a server operated by DH Consultancy, which also hosts a web interface providing browsing, plotting and post-processing and analysis tools developed by the consortium, as well as a Solar Energetic Particle event catalogue. At this stage of the project, a prototype server has been established, which is presently undergoing testing by users inside the consortium. Using a centralized database has numerous advantages, including: homogeneous storage of the data, which eliminates the need for dataset specific file access routines once the data are ingested in the database; a homogeneous set of metadata describing the datasets on both a global and detailed level, allowing for automated access to and presentation of the various data products; standardised access to the data in different programming environments (e.g. php, IDL); elimination of the need to download data for individual data requests. SEPServer will, thus, add value to several space missions and Earth-based observations by facilitating the coordinated exploitation of and open access to SEP data and related EM observations, and promoting correct use of these data for the entire space research community. This will lead to new knowledge on the production and transport of SEPs during solar eruptions and facilitate the development of models for predicting solar radiation storms and calculation of expected fluxes/fluences of SEPs encountered by spacecraft in the interplanetary medium.

JPRS Report. Near East & South Asia.

DTIC Science & Technology

1990-11-02

Discussed [YEDI’OT AHARONOT17 Sep] 7 Economic Forecasts for New Year Given [MA’ARJV(Business Supplement) 18 Sep] 9 SOUTH ASIA INDIA Report...November Polls [THE TIMES OF INDIA 20 Sep] 18 Reservation Policy Seen Creating Discord, Divisions [ANANDA BAZAR PATRIKA 18 Aug] 18 Congress-BJP...8217Unrealistic’ [THE HINDU 20 Sep] 28 Officials Predict Record Foodgrain Production [THE TIMES OF INDIA 14 Sep] 29 Commentary Questions State

JPRS Report, Environmental Issues

DTIC Science & Technology

1990-10-12

IZVESTIYA 18 Sep] 33 UN Mission To Study Chernobyl Effects [TASS 19 Sep] 33 Rumors of’Crack’in Chernobyl Sarcophagus Rebutted [PRAVDA 18...Sep] 33 Russian Parliament Sets Up Chernobyl Committee [TASS 19 Sep] 34 Uranium Wastes Said Contaminating Kirovograd [Moscow TV 18 Sep] 35...following the Chernobyl disaster. The find- ings make it possible to reach conclusions about Cher- nobyl’s impact on the environment in those regions. The

Solar Electric Propulsion (SEP) Tug Power System Considerations

NASA Technical Reports Server (NTRS)

Kerslake, Thomas W.; Bury, Kristen M.; Hojinicki, Jeffrey S.; Sajdak, Adam M.; Scheiddegger, Robert J.

2011-01-01

Solar electric propulsion (SEP) technology is truly at the "intersection of commercial and military space" as well as the intersection of NASA robotic and human space missions. Building on the use of SEP for geosynchronous spacecraft station keeping, there are numerous potential commercial and military mission applications for SEP stages operating in Earth orbit. At NASA, there is a resurgence of interest in robotic SEP missions for Earth orbit raising applications, 1-AU class heliocentric missions to near Earth objects (NEOs) and SEP spacecraft technology demonstrations. Beyond these nearer term robotic missions, potential future human space flight missions to NEOs with high-power SEP stages are being considered. To enhance or enable this broad class of commercial, military and NASA missions, advancements in the power level and performance of SEP technologies are needed. This presentation will focus on design considerations for the solar photovoltaic array (PVA) and electric power system (EPS) vital to the design and operation of an SEP stage. The engineering and programmatic pros and cons of various PVA and EPS technologies and architectures will be discussed in the context of operating voltage and power levels. The impacts of PVA and EPS design options on the remaining SEP stage subsystem designs, as well as spacecraft operations, will also be discussed.

Life-Course Socioeconomic Position and Hypertension in African American Men: The Pitt County Study

PubMed Central

James, Sherman A.; Van Hoewyk, John; Belli, Robert F.; Strogatz, David S.; Williams, David R.; Raghunathan, Trevillore E.

2006-01-01

Objectives. We investigated the odds of hypertension for Black men in relationship to their socioeconomic position (SEP) in both childhood and adulthood. Methods. On the basis of their parents’ occupation, we classified 379 men in the Pitt County (North Carolina) Study into low and high childhood SEP. The men’s own education, occupation, employment status, and home ownership status were used to classify them into low and high adulthood SEP. Four life-course SEP categories resulted: low childhood/low adulthood, low childhood/high adulthood, high childhood/low adulthood, and high childhood/high adulthood. Results. Low childhood SEP was associated with a 60% greater odds of hypertension, and low adulthood SEP was associated with a 2-fold greater odds of hypertension. Compared with men of high SEP in both childhood and adulthood, the odds of hypertension were 7 times greater for low/low SEP men, 4 times greater for low/high SEP men, and 6 times greater for high/low SEP men. Conclusions. Greater access to material resources in both childhood and adulthood was protective against premature hypertension in this cohort of Black men. Though some parameter estimates were imprecise, study findings are consistent with both pathway and cumulative burden models of hypertension. PMID:16571689

Describing socioeconomic gradients in children’s diets – does the socioeconomic indicator used matter?

PubMed Central

2014-01-01

Background Children of low socioeconomic position (SEP) generally have poorer diets than children of high SEP. However there is no consensus on which SEP variable is most indicative of SEP differences in children’s diets. This study investigated associations between diet and various SEP indicators among children aged 9–13 years. Method Families (n = 625) were recruited from 27 Adelaide primary schools in 2010. Children completed semi-quantitative food frequency questionnaires providing intake scores for fruit, vegetables, non-core foods, sweetened drinks, and healthy and unhealthy eating behaviours. Parents reported demographic information by telephone interview. Differences in dietary intake scores were compared across parental education, income, occupation, employment status and home postcode. Results Across most SEP indicators, lower SEP was associated with poorer dietary outcomes, including higher intake of non-core foods and sweetened drinks, and more unhealthy behaviours; and lower intake of fruit and vegetables, and fewer healthy behaviours. The number and type of significant SEP-diet associations differed across SEP indicators and dietary outcomes. Mother’s education appeared most frequently as a predictor of children’s dietary intake, and postcode was the least frequent predictor of children’s dietary intake. Conclusion Socioeconomic gradients in children’s dietary intake varied according to the SEP indicator used, suggesting indicator-specific pathways of influence on children’s dietary intake. Researchers should consider multiple indicators when defining SEP in relation to children’s eating. PMID:24674231

Application of Solar-Electric Propulsion to Robotic Missions in Near-Earth Space

NASA Technical Reports Server (NTRS)

Woodcock, Gordon R.; Dankanich, John

2007-01-01

Interest in applications of solar electric propulsion (SEP) is increasing. Application of SEP technology is favored when: (1) the mission is compatible with low-thrust propulsion, (2) the mission needs high total delta V such that chemical propulsion is disadvantaged; and (3) performance enhancement is needed. If all such opportunities for future missions are considered, many uses of SEP are likely. Representative missions are surveyed and several SEP applications selected for analysis, including orbit raising, lunar science and robotic exploration, and planetary science. These missions span SEP power range from 10 kWe to about 100 kWe. A SEP design compatible with small inexpensive launch vehicles, and capable of lunar science missions, is presented. Modes of use and benefits are described, and potential SEP evolution is discussed.

Electrodiagnostic applications of somatosensory evoked high-frequency EEG oscillations: Technical considerations.

PubMed

Simpson, A J; Cunningham, M O; Baker, M R

2018-03-01

High frequency oscillations (HFOs) embedded within the somatosensory evoked potential (SEP) are not routinely recorded/measured as part of standard clinical SEPs. However, HFOs could provide important additional diagnostic/prognostic information in various patient groups in whom SEPs are tested routinely. One area is the management of patients with hypoxic ischaemic encephalopathy (HIE) in the intensive care unit (ICU). However, the sensitivity of standard clinical SEP recording techniques for detecting HFOs is unknown. SEPs were recorded using routine clinical methods in 17 healthy subjects (median nerve stimulation; 0.5 ms pulse width; 5 Hz; maximum 4000 stimuli) in an unshielded laboratory. Bipolar EEG recordings were acquired (gain 50 k; bandpass 3Hz-2 kHz; sampling rate 5 kHz; non-inverting electrode 2 cm anterior to C3/C4; inverting electrode 2 cm posterior to C3/C4). Data analysis was performed in MATLAB. SEP-HFOs were detected in 65% of controls using standard clinical recording techniques. In 3 controls without significant HFOs, experiments were repeated using a linear electrode array with higher spatial sampling frequency. SEP-HFOs were observed in all 3 subjects. Currently standard clinical methods of recording SEPs are not sufficiently sensitive to permit the inclusion of SEP-HFOs in routine clinical diagnostic/prognostic assessments. Whilst an increase in the number/density of EEG electrodes should improve the sensitivity for detecting SEP-HFOs, this requires confirmation. By improving and standardising clinical SEP recording protocols to permit the acquisition/analysis of SEP-HFOs, it should be possible to gain important insights into the pathophysiology of neurological disorders and refine the management of conditions such as HIE. Copyright © 2018. Published by Elsevier Inc.

Salsalate and Adiponectin Improve Palmitate-Induced Insulin Resistance via Inhibition of Selenoprotein P through the AMPK-FOXO1α Pathway.

PubMed

Jung, Tae Woo; Choi, Hae Yoon; Lee, So Young; Hong, Ho Cheol; Yang, Sae Jeong; Yoo, Hye Jin; Youn, Byung-Soo; Baik, Sei Hyun; Choi, Kyung Mook

2013-01-01

Selenoprotein P (SeP) was recently identified as a hepatokine that induces insulin resistance (IR) in rodents and humans. Recent clinical trials have shown that salsalate, a prodrug of salicylate, significantly lowers blood glucose levels and increases adiponectin concentrations. We examined the effects of salsalate and full length-adiponectin (fAd) on the expression of SeP under hyperlipidemic conditions and explored their regulatory mechanism on SeP. In palmitate-treated HepG2 cells as well as high fat diet (HFD)-fed male Spraque Dawley (SD) rats and male db/db mice, SeP expression and its regulatory pathway, including AMPK-FOXO1α, were evaluated after administration of salsalate and salicylate. Palmitate treatment significantly increased SeP expression and aggravated IR, while knock-down of SeP by siRNA restored these changes in HepG2 cells. Palmitate-induced SeP expression was inhibited by both salsalate and salicylate, which was mediated by AMPK activation, and was blocked by AMPK siRNA or an inhibitor of AMPK. Chromatin immunoprecipitation (ChIP) and electrophoretic mobility shift (EMSA) assay showed that salsalate suppressed SeP expression by AMPK-mediated phosphorylation of FOXO1α. Moreover, fAd also reduced palmitate-induced SeP expression through the activation of AMPK, which results in improved IR. Both salsalate and salicylate treatment significantly improved glucose intolerance and insulin sensitivity, accompanied by reduced SeP mRNA and protein expression in HFD-fed rats and db/db mice, respectively. Taken together, we found that salsalate and adiponectin ameliorated palmitate-induced IR in hepatocytes via SeP inhibition through the AMPK-FOXO1α pathway. The regulation of SeP might be a novel mechanism mediating the anti-diabetic effects of salsalate and adiponectin.

Framework for Managing Metadata Security Tags as the Basis for Making Security Decisions.

DTIC Science & Technology

2002-12-01

and Performance,” D.H. Associates, Inc., Sep 2001. [3] Deitel , H. M., and Deitel , P. J., Java How to Program , 3rd Edition, Prentice Hall Inc...1999. [4] Deitel , H. M., Deitel , P. J., and Nieto, T. R., Internet and The World Wide Web: How to Program , 2nd Edition, 2002. [5] Grohn, M. J., A...words) This thesis presents an analysis of a capability to employ CAPCO (Controlled Access Program Coordination Office) compliant Metadata security

The Role of Leadership in Navy Program Offices. Executive Summary

DTIC Science & Technology

1973-05-01

PROGRAM MANAGEMENT COURSE- SSTUDENT STUDY PROGRAM Fort Beivoir, Virginia, 22060 THE ROLE OF LEADERSHIP IN NAVY PROGRAM OFFICES STUDY REPORT PMC 73-1...jLa I1 • 1. Men at the Top. Osborne kLliott 1 2. "Understanding Leadership ". W. 0. H. Prentice, HBR Sep- Oct 1966 j 3. "A Theory of Human Motivation...Drucker, IMI reprint 9. Technical Management Institute Thifnkpiece, " Leadership " 1 • 0. "The Effective Manager ". Peter Drucker, LMI r~print 11. Sur-ival In

Early life socioeconomic position and immune response to persistent infections among elderly Latinos.

PubMed

Meier, Helen C S; Haan, Mary N; Mendes de Leon, Carlos F; Simanek, Amanda M; Dowd, Jennifer B; Aiello, Allison E

2016-10-01

Persistent infections, such as cytomegalovirus (CMV), herpes simplex virus-1 (HSV-1), Helicobacter pylori (H. pylori), and Toxoplasma gondii (T. gondii), are common in the U.S. but their prevalence varies by socioeconomic status. It is unclear if early or later life socioeconomic position (SEP) is a more salient driver of disparities in immune control of these infections. Using data from the Sacramento Area Latino Study on Aging, we examined whether early or later life SEP was the strongest predictor of immune control later in life by contrasting two life course models, the critical period model and the chain of risk model. Early life SEP was measured as a latent variable, derived from parental education and occupation, and food availability. Indicators for SEP in later life included education level and occupation. Individuals were categorized by immune response to each pathogen (seronegative, low, medium and high) with increasing immune response representing poorer immune control. Cumulative immune response was estimated using a latent profile analysis with higher total immune response representing poorer immune control. Structural equation models were used to examine direct, indirect and total effects of early life SEP on each infection and cumulative immune response, controlling for age and gender. The direct effect of early life SEP on immune response was not statistically significant for the infections or cumulative immune response. Higher early life SEP was associated with lower immune response for T. gondii, H. pylori and cumulative immune response through pathways mediated by later life SEP. For CMV, higher early life SEP was both directly associated and partially mediated by later life SEP. No association was found between SEP and HSV-1. Findings from this study support a chain of risk model, whereby early life SEP acts through later life SEP to affect immune response to persistent infections in older age. Copyright © 2016 Elsevier Ltd. All rights reserved.

Treatment of chronic subdural hematomas with subdural evacuating port system placement in the intensive care unit: evolution of practice and comparison with bur hole evacuation in the operating room.

PubMed

Flint, Alexander C; Chan, Sheila L; Rao, Vivek A; Efron, Allen D; Kalani, Maziyar A; Sheridan, William F

2017-12-01

OBJECTIVE The aims of this study were to evaluate a multiyear experience with subdural evacuating port system (SEPS) placement for chronic subdural hematoma (cSDH) in the intensive care unit at a tertiary neurosurgical center and to compare SEPS placement with bur hole evacuation in the operating room. METHODS All cases of cSDH evacuation were captured over a 7-year period at a tertiary neurosurgical center within an integrated health care delivery system. The authors compared the performance characteristics of SEPS and bur hole placement with respect to recurrence rates, change in recurrence rates over time, complications, length of stay, discharge disposition, and mortality rates. RESULTS A total of 371 SEPS cases and 659 bur hole cases were performed (n = 1030). The use of bedside SEPS placement for cSDH treatment increased over the 7-year period, from 14% to 80% of cases. Reoperation within 6 months was higher for the SEPS (15.6%) than for bur hole drainage (9.1%) across the full 7-year period (p = 0.002). This observed overall difference was due to a higher rate of reoperation during the same hospitalization (7.0% for SEPS vs 3.2% for bur hole; p = 0.008). Over time, as the SEPS procedure became more common and modifications of the SEPS technique were introduced, the rate of in-hospital reoperation after SEPS decreased to 3.3% (p = 0.02 for trend), and the difference between SEPS and bur hole recurrence was no longer significant (p = 0.70). Complications were uncommon and were similar between the groups. CONCLUSIONS Overall performance characteristics of bedside SEPS and bur hole drainage in the operating room were similar. Modifications to the SEPS technique over time were associated with a reduced reoperation rate.

Transport of Solar Energetic Particles across the Parker field direction due to field line meandering

NASA Astrophysics Data System (ADS)

Laitinen, T. L.; Kopp, A.; Effenberger, F.; Dalla, S.; Marsh, M. S.

2014-12-01

Multi-spacecraft observations of Solar Energetic Particles (SEPs) show that the SEPs can spread large distances across the mean Parker spiral field. The SEPs accelerated during a solar eruption can be observed 360° around the Sun, and the dependence of SEP peak intensity on heliographic longitude at 1 AU has been fitted with Gaussian profiles with σ=30-50° for several events (e.g., Dresing et al 2014; Richardson et al 2014). SEP anisotropy measurements suggest that interplanetary transport is an important factor to the SEP cross-field extent (Dresing et al 2014). However, the currently used diffusive Fokker Planck (FP) description of SEP transport, with realistic diffusion coefficients, has been found insufficient to explain the SEP event cross-field extents. Recently Laitinen et al (2013) emphasised the importance of particle propagation along meandering field lines, which cannot be described as diffusion. They showed that early in an event field line meandering dominates particle cross-field transport and produces events wider than the FP description. They also introduced a new FP model that incorporates both field line meandering and SEP cross-field diffusion using stochastic differential equations and a constant background magnetic field. In this work, we implement the new FP model into Parker field geometry, to study the evolution of an SEP event in the interplanetary space. We compare the new model to the traditional FP approach by using particle and field line diffusion coefficients that are calculated consistently for both models using an assumed radial and spectral description of the turbulence evolution. We find that while the traditional SEP propagation modelling gives typically longitudinal extent with σ=10-20°, the new model results in values σ=30-50°, which is consistent with SEP observations. We conclude that field line meandering must be taken into account when modelling SEP propagation in the interplanetary space.

Department of the Navy Acquisition and Capabilities Guidebook

DTIC Science & Technology

2012-05-01

Cost Estimates/Service Cost Position..................................... 5-1 5.1.2 Cost Analysis Requirements Description ( CARD ) 5-2 5.1.3...Description ( CARD ). 7. Satisfactory review of program health. 8. Concurrence with draft TDS, TES, and SEP. 9. Approval of full funding...Description ( CARD ) SECNAV M-5000.2 May 2012 5-3 Enclosure (1) A sound cost estimate is based on a well-defined program. The CARD is used

Elemental composition of solar energetic particles

NASA Technical Reports Server (NTRS)

Cook, W. R.; Stone, E. C.; Vogt, R. E.

1984-01-01

The Low Energy Telescopes on the Voyager spacecraft have been used to measure the elemental composition (Z = 2-28) and energy spectra (5-15 MeV per nucleon) of solar energetic particles (SEPs) in seven large flare events. Four flare events were selected which have SEP abundance ratios approximately independent of energy per nucleon. For these selected flare events, SEP composition results may be described by an average composition plus a systematic flare-to-flare deviation about the average. The four-flare average SEP composition is systematically different from the solar composition determined by photospheric spectroscopy. These systematic composition differences are apparently not due to SEP propagation or acceleration effects. In contrast, the four-flare average SEP composition is in agreement with measured solar wind abundances and with a number of recent spectroscopic coronal abundance measurements. These findings suggest that SEPs originate in the corona, and that both SEPs and the solar wind sample a coronal composition which is significantly and persistently different from that measured for the photosphere.

Application of Solar-Electric Propulsion to Robotic and Human Missions in Near-Earth Space

NASA Technical Reports Server (NTRS)

Woodcock, Gordon

2006-01-01

Solar-electric propulsion (SEP) is becoming of interest for application to a wide range of missions. The benefits of SEP are strongly influenced by system element performance, especially that for the power system. Solar array performance is increasing rapidly and promises to continue to do so for another 10 to 20 years (Fig. 1). At the same time, cost per watt is decreasing. Radiation hardness is increasing. New concepts for how to design a SEP are emerging. These improvements lead to changes in the best ways to apply SEP technology to missions, and broadening of the practical uses of SEP technology compared to competing technologies. This paper addresses the evolving characteristics of SEP technology from the point of view of mission design, and how mission profile characteristics can be designed to best take advantage of evolving SEP characteristics. Mission concepts include robotic lunar landers and orbiters; scientific planetary spacecraft; delivery of spacecraft to geosynchronous orbit from inclined and low-inclination launch orbits; and lunar cargo delivery from Earth orbit to lunar orbit. Expendable and re-usable SEP profiles are considered. Flight control considerations are abstracted from recent papers by the author to describe how these influence SEP design and operations.

The electron-furfural scattering dynamics for 63 energetically open electronic states

NASA Astrophysics Data System (ADS)

da Costa, Romarly F.; do N. Varella, Márcio T.; Bettega, Márcio H. F.; Neves, Rafael F. C.; Lopes, Maria Cristina A.; Blanco, Francisco; García, Gustavo; Jones, Darryl B.; Brunger, Michael J.; Lima, Marco A. P.

2016-03-01

We report on integral-, momentum transfer- and differential cross sections for elastic and electronically inelastic electron collisions with furfural (C5H4O2). The calculations were performed with two different theoretical methodologies, the Schwinger multichannel method with pseudopotentials (SMCPP) and the independent atom method with screening corrected additivity rule (IAM-SCAR) that now incorporates a further interference (I) term. The SMCPP with N energetically open electronic states (Nopen) at either the static-exchange (Nopen ch-SE) or the static-exchange-plus-polarisation (Nopen ch-SEP) approximation was employed to calculate the scattering amplitudes at impact energies lying between 5 eV and 50 eV, using a channel coupling scheme that ranges from the 1ch-SEP up to the 63ch-SE level of approximation depending on the energy considered. For elastic scattering, we found very good overall agreement at higher energies among our SMCPP cross sections, our IAM-SCAR+I cross sections and the experimental data for furan (a molecule that differs from furfural only by the substitution of a hydrogen atom in furan with an aldehyde functional group). This is a good indication that our elastic cross sections are converged with respect to the multichannel coupling effect for most of the investigated intermediate energies. However, although the present application represents the most sophisticated calculation performed with the SMCPP method thus far, the inelastic cross sections, even for the low lying energy states, are still not completely converged for intermediate and higher energies. We discuss possible reasons leading to this discrepancy and point out what further steps need to be undertaken in order to improve the agreement between the calculated and measured cross sections.

Oxygen Pickup Ions Measured by MAVEN Outside the Martian Bow Shock

NASA Astrophysics Data System (ADS)

Rahmati, A.; Cravens, T.; Larson, D. E.; Lillis, R. J.; Dunn, P.; Halekas, J. S.; Connerney, J. E. P.; Eparvier, F. G.; Thiemann, E.; Mitchell, D. L.; Jakosky, B. M.

2015-12-01

The MAVEN (Mars Atmosphere and Volatile EvolutioN) spacecraft entered orbit around Mars on September 21, 2014 and has since been detecting energetic oxygen pickup ions by its SEP (Solar Energetic Particles) and SWIA (Solar Wind Ion Analyzer) instruments. The oxygen pickup ions detected outside the Martian bowshock and in the upstream solar wind are associated with the extended hot oxygen exosphere of Mars, which is created mainly by the dissociative recombination of molecular oxygen ions with electrons in the ionosphere. We use analytic solutions to the equations of motion of pickup ions moving in the undisturbed upstream solar wind magnetic and motional electric fields and calculate the flux of oxygen pickup ions at the location of MAVEN. Our model calculates the ionization rate of oxygen atoms in the exosphere based on the hot oxygen densities predicted by Rahmati et al. (2014), and the sources of ionization include photo-ionization, charge exchange, and electron impact ionization. The photo-ionization frequency is calculated using the FISM (Flare Irradiance Spectral Model) solar flux model, based on MAVEN EUVM (Extreme Ultra-Violet Monitor) measurements. The frequency of charge exchange between a solar wind proton and an oxygen atom is calculated using MAVEN SWIA solar wind proton flux measurements, and the electron impact ionization frequency is calculated based on MAVEN SWEA (Solar Wind Electron Analyzer) solar wind electron flux measurements. The solar wind magnetic field used in the model is from the measurements taken by MAVEN MAG (magnetometer) in the upstream solar wind. The good agreement between our predicted pickup oxygen fluxes and the MAVEN SEP and SWIA measured ones confirms detection of oxygen pickup ions and these model-data comparisons can be used to constrain models of hot oxygen densities and photochemical escape flux.

The electron-furfural scattering dynamics for 63 energetically open electronic states

DOE Office of Scientific and Technical Information (OSTI.GOV)

Costa, Romarly F. da; Centro de Ciências Naturais e Humanas, Universidade Federal do ABC, Santo André, São Paulo 09210-580; Varella, Márcio T. do N

We report on integral-, momentum transfer- and differential cross sections for elastic and electronically inelastic electron collisions with furfural (C{sub 5}H{sub 4}O{sub 2}). The calculations were performed with two different theoretical methodologies, the Schwinger multichannel method with pseudopotentials (SMCPP) and the independent atom method with screening corrected additivity rule (IAM-SCAR) that now incorporates a further interference (I) term. The SMCPP with N energetically open electronic states (N{sub open}) at either the static-exchange (N{sub open} ch-SE) or the static-exchange-plus-polarisation (N{sub open} ch-SEP) approximation was employed to calculate the scattering amplitudes at impact energies lying between 5 eV and 50 eV, using a channelmore » coupling scheme that ranges from the 1ch-SEP up to the 63ch-SE level of approximation depending on the energy considered. For elastic scattering, we found very good overall agreement at higher energies among our SMCPP cross sections, our IAM-SCAR+I cross sections and the experimental data for furan (a molecule that differs from furfural only by the substitution of a hydrogen atom in furan with an aldehyde functional group). This is a good indication that our elastic cross sections are converged with respect to the multichannel coupling effect for most of the investigated intermediate energies. However, although the present application represents the most sophisticated calculation performed with the SMCPP method thus far, the inelastic cross sections, even for the low lying energy states, are still not completely converged for intermediate and higher energies. We discuss possible reasons leading to this discrepancy and point out what further steps need to be undertaken in order to improve the agreement between the calculated and measured cross sections.« less

Arabidopsis SEPALLATA proteins differ in cooperative DNA-binding during the formation of floral quartet-like complexes

PubMed Central

Jetha, Khushboo; Theißen, Günter; Melzer, Rainer

2014-01-01

The SEPALLATA (SEP) genes of Arabidopsis thaliana encode MADS-domain transcription factors that specify the identity of all floral organs. The four Arabidopsis SEP genes function in a largely yet not completely redundant manner. Here, we analysed interactions of the SEP proteins with DNA. All of the proteins were capable of forming tetrameric quartet-like complexes on DNA fragments carrying two sequence elements termed CArG-boxes. Distances between the CArG-boxes for strong cooperative DNA-binding were in the range of 4–6 helical turns. However, SEP1 also bound strongly to CArG-box pairs separated by smaller or larger distances, whereas SEP2 preferred large and SEP4 preferred small inter-site distances for binding. Cooperative binding of SEP3 was comparatively weak for most of the inter-site distances tested. All SEP proteins constituted floral quartet-like complexes together with the floral homeotic proteins APETALA3 (AP3) and PISTILLATA (PI) on the target genes AP3 and SEP3. Our results suggest an important part of an explanation for why the different SEP proteins have largely, but not completely redundant functions in determining floral organ identity: they may bind to largely overlapping, but not identical sets of target genes that differ in the arrangement and spacing of the CArG-boxes in their cis-regulatory regions. PMID:25183521

Filament overwrapped motor case technology

NASA Astrophysics Data System (ADS)

Compton, Joel P.

1993-11-01

Atlantic Research Corporation (ARC) joined with the French Societe Europeenne de Propulsion (SEP) to develop and deliver to the U.S. Navy a small quantity of composite filament wound rocket motors to demonstrate a manufacturing technique that was being applied at the two companies. It was perceived that the manufacturing technique could produce motors that would be light in weight, inexpensive to produce, and that had a good chance of meeting insensitive munitions (IM) requirements that were being formulated by the Navy in the early 1980s. Under subcontract to ARC, SEP designed, tested, and delivered 2.75-inch rocket motors to the U.S. Navy for IM tests that were conducted in 1989 at China Lake, California. The program was one of the first to be founded by Nunn Amendment money. The Government-to-Government program was sponsored by the Naval Air Systems Command and was monitored by the Naval Surface Warfare Center, Indian Head (NSWC-IH), Maryland. The motor propellant that was employed was a new, extruded composite formulation that was under development at the Naval Surface Warfare Center. The following paper describes the highlights of the program and gives the results of structural and ballistic static tests and insensitive munitions tests that were conducted on demonstration motors.

Injecting risk behavior among traveling young injection drug users: travel partner and city characteristics.

PubMed

Montgomery, Martha E; Fatch, Robin S; Evans, Jennifer L; Yu, Michelle; Davidson, Peter J; Page, Kimberly; Hahn, Judith A

2013-06-01

Young injection drug users (IDUs), a highly mobile population, engage in high levels of injecting risk behavior, yet little is understood about how such risk behavior may vary by the characteristics of the cities to which they travel, including the existence of a syringe exchange program (SEP), as well as travel partner characteristics. In 2004-2005, we conducted a 6-month prospective study to investigate the risk behavior of 89 young IDUs as they traveled, with detailed information gathered about 350 city visits. In multivariable analyses, travel to larger urban cities with a population of 500,000-1,000,000 was significantly associated with injecting drugs (adjusted odds ratio (AOR) = 3.71; 95 % confidence interval (CI), 1.56-8.82), ancillary equipment sharing (AES; AOR = 7.05; 95 % CI, 2.25-22.06) and receptive needle sharing (RNS; AOR = 5.73; 95 % CI, 1.11-27.95), as compared with visits to smaller cities with populations below 50,000. Region of the country, and the existence of a SEP within the city visited, were not independently associated with injecting drugs, AES, or RNS during city visits. Traveling with more than one injecting partner was associated with injecting drugs during city visits (AOR = 2.77; 95 % CI, 1.46-5.27), when compared with traveling alone. Additionally, both non-daily and daily/almost daily alcohol use during city visits were associated with AES (AOR = 3.37; 95 % CI, 1.42-7.68; AOR = 3.03; 95 % CI, 1.32-6.97, respectively) as compared with no alcohol consumption. Traveling young IDUs are more likely to inject when traveling with other IDUs and to engage in higher risk injection behavior when they are in large cities. Risk behavior occurring in city visits, including equipment sharing and alcohol consumption, suggests further need for focused interventions to reduce risk for viral infection among this population.

Strategic Goals Implementation Plan V2.0

DTIC Science & Technology

2008-01-01

newest ATARS ground station. (Sep 08) (DDR&E) 3.1.6 Take proactive steps to transition technology programs. DUSD(AS&C) • Proactive steps taken to...increases emphasis on math as gateway to physical science and engineering. • Expanded footprint of S&E education in Middle School. 3.3.4 Support

76 FR 32213 - Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP); Initial Review

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-03

... announced below concerns Human Immunodeficiency Virus (HIV) Prevention Projects for Young Men of Color..., Extramural Programs, National Center for HIV, Hepatitis and Sexually Transmitted Diseases Prevention, CDC, 1600 Clifton Road, NE., Mailstop E-60, Atlanta, Georgia 30333, Telephone: (404) 498-2726, e- mail...

LCRE and SNAP 50-DR-1 programs. Engineering and progress report, April 1, 1963--June 30, 1963

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

BS>Declassified 6 Sep 1973. Information is presented concerning the LCRE kinetics, auxiliary systems, fuel, primary cooling system components, instrumentation, secondary cooling system, materials development, and fabrication; and SNAP-50/SPUR kinetics, fuel, primary system pump, steam generator, and materials development. (DCC)

10 CFR 420.31 - Notice of availability.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 10 Energy 3 2014-01-01 2014-01-01 false Notice of availability. 420.31 Section 420.31 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION STATE ENERGY PROGRAM Implementation of Special Projects Financial... projects, DOE shall publish in the Federal Register one or more notice(s) of availability of SEP special...

10 CFR 420.31 - Notice of availability.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 3 2010-01-01 2010-01-01 false Notice of availability. 420.31 Section 420.31 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION STATE ENERGY PROGRAM Implementation of Special Projects Financial... projects, DOE shall publish in the Federal Register one or more notice(s) of availability of SEP special...

10 CFR 420.31 - Notice of availability.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 10 Energy 3 2013-01-01 2013-01-01 false Notice of availability. 420.31 Section 420.31 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION STATE ENERGY PROGRAM Implementation of Special Projects Financial... projects, DOE shall publish in the Federal Register one or more notice(s) of availability of SEP special...

10 CFR 420.31 - Notice of availability.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 10 Energy 3 2011-01-01 2011-01-01 false Notice of availability. 420.31 Section 420.31 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION STATE ENERGY PROGRAM Implementation of Special Projects Financial... projects, DOE shall publish in the Federal Register one or more notice(s) of availability of SEP special...

10 CFR 420.31 - Notice of availability.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 10 Energy 3 2012-01-01 2012-01-01 false Notice of availability. 420.31 Section 420.31 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION STATE ENERGY PROGRAM Implementation of Special Projects Financial... projects, DOE shall publish in the Federal Register one or more notice(s) of availability of SEP special...

JPRS Report Environmental Issues.

DTIC Science & Technology

1990-11-02

Program Views Environmental Effects [0 GLOBO 30 Sep] ............................. 31 Environmental Affairs Institute Fines Illegal Amazon Lumber...ERICA 12 Oct] .................................................................................................. 33 PERU Court Nullifies Soviet Fishing...34. He said loss of forests in Burma remains at only 0.3 He disputed reports that logs are being cut down ran- percent of forest cover per year, or

76 FR 56461 - Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Initial Review

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-13

... DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Disease Control and Prevention Disease... announced below concerns Emerging Infections Programs, Funding Opportunity Announcement (FOA), CK12-1202...), the Centers for Disease Control and Prevention (CDC) announces the aforementioned meeting: Time and...

76 FR 4702 - Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Member...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-26

... Occupational Safety and Health (NIOSH), CDC, 1095 Willowdale Road, Morgantown, West Virginia 26506, telephone... Programs, National Institute for Occupational Safety and Health, CDC, 1600 Clifton Road, NE., Mailstop E74..., has been delegated the authority to sign Federal Register notices pertaining to announcements of...

75 FR 10490 - Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Member...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-08

... Institute for Occupational Safety and Health (NIOSH), CDC, 1095 Willowdale Road, Morgantown, West Virginia... of Extramural Programs, National Institute for Occupational Safety and Health, CDC, 1600 Clifton Road... Analysis and Services Office, has been delegated the authority to sign Federal Register notices pertaining...

1972 Annual Typhoon Report

DTIC Science & Technology

1995-01-01

TRAVELED— .— 01 T KIT 05 JAN-09 J&? 4 120 02 933 15 5 TD TD 02 840 31 MAR-01 APR 2 30 1001 s 03 ‘T -- LOLA 185 30 MAY-05 JUN 7 04 105 TS 956 26 13...T 974 16 12 580 FLOSSIE 10 SEP-16 SEP 7 75 975 25 19 7 TS GRACE 795 *12 SEP-18 SEP 5 989 12 20 T HELEN 495 13 SEP-16 SEP 4 1:8 957 1s ‘- TD .13 TD 21...of Hong Kong for such a long dura- tion as Susan. FIGURE 4-13. Low ~c3v12~ c.toud.inebbbpihdb iVLOU) td ~kt cen.tefi06 Suban [04 m.inima.t.tgphoon

[Reflections on drug policies in Brazil].

PubMed

de Andrade, Tarcísio Matos

2011-12-01

This article contains some reflections on drug policies in Brazil. In the first two chapters, taking the needle exchange programs (SEPs) as the starting point, the author discusses the trajectory of the Harm Reduction Policy in Brazil and the role played in it by the Department of STD, AIDS and Viral Hepatitis. The third chapter examines the actions developed by the National Coordination of Mental Health, Alcohol and Other Drugs and the Office of Drug Policies - SENAD, after the retraction of the Department of STD and AIDS from drug policies, as well as the introduction of PEAD and the "Crack Plan" in the country. In the fourth and fifth chapters the provisions of the current Brazilian policy on drugs and its limitations related mainly to the fragility of the Family Health Strategy are discussed, and some of the actions foreseen in the PEAD and the "Crack Plan" are critically analyzed. In the sixth chapter the author examines the effects of repression in the name of combating trafficking in the Brazilian policy on drugs having as background of the marginalization and social exclusion of users. Finally, some proposals are presented for the Alcohol and Drugs Policy in Brazil.

Improvement of the SEP protocol based on community structure of node degree

NASA Astrophysics Data System (ADS)

Li, Donglin; Wei, Suyuan

2017-05-01

Analyzing the Stable election protocol (SEP) in wireless sensor networks and aiming at the problem of inhomogeneous cluster-heads distribution and unreasonable cluster-heads selectivity and single hop transmission in the SEP, a SEP Protocol based on community structure of node degree (SEP-CSND) is proposed. In this algorithm, network node deployed by using grid deployment model, and the connection between nodes established by setting up the communication threshold. The community structure constructed by node degree, then cluster head is elected in the community structure. On the basis of SEP, the node's residual energy and node degree is added in cluster-heads election. The information is transmitted with mode of multiple hops between network nodes. The simulation experiments showed that compared to the classical LEACH and SEP, this algorithm balances the energy consumption of the entire network and significantly prolongs network lifetime.

Automatic Parametrization of Somatosensory Evoked Potentials With Chirp Modeling.

PubMed

Vayrynen, Eero; Noponen, Kai; Vipin, Ashwati; Thow, X Y; Al-Nashash, Hasan; Kortelainen, Jukka; All, Angelo

2016-09-01

In this paper, an approach using polynomial phase chirp signals to model somatosensory evoked potentials (SEPs) is proposed. SEP waveforms are assumed as impulses undergoing group velocity dispersion while propagating along a multipath neural connection. Mathematical analysis of pulse dispersion resulting in chirp signals is performed. An automatic parameterization of SEPs is proposed using chirp models. A Particle Swarm Optimization algorithm is used to optimize the model parameters. Features describing the latencies and amplitudes of SEPs are automatically derived. A rat model is then used to evaluate the automatic parameterization of SEPs in two experimental cases, i.e., anesthesia level and spinal cord injury (SCI). Experimental results show that chirp-based model parameters and the derived SEP features are significant in describing both anesthesia level and SCI changes. The proposed automatic optimization based approach for extracting chirp parameters offers potential for detailed SEP analysis in future studies. The method implementation in Matlab technical computing language is provided online.

Perceived extrinsic mortality risk and reported effort in looking after health: testing a behavioral ecological prediction.

PubMed

Pepper, Gillian V; Nettle, Daniel

2014-09-01

Socioeconomic gradients in health behavior are pervasive and well documented. Yet, there is little consensus on their causes. Behavioral ecological theory predicts that, if people of lower socioeconomic position (SEP) perceive greater personal extrinsic mortality risk than those of higher SEP, they should disinvest in their future health. We surveyed North American adults for reported effort in looking after health, perceived extrinsic and intrinsic mortality risks, and measures of SEP. We examined the relationships between these variables and found that lower subjective SEP predicted lower reported health effort. Lower subjective SEP was also associated with higher perceived extrinsic mortality risk, which in turn predicted lower reported health effort. The effect of subjective SEP on reported health effort was completely mediated by perceived extrinsic mortality risk. Our findings indicate that perceived extrinsic mortality risk may be a key factor underlying SEP gradients in motivation to invest in future health.

Effect of solar energetic particle (SEP) events on the radiation exposure levels to aircraft passengers and crew: Case study of 14 July 2000 SEP event

NASA Astrophysics Data System (ADS)

Iles, R. H. A.; Jones, J. B. L.; Taylor, G. C.; Blake, J. B.; Bentley, R. D.; Hunter, R.; Harra, L. K.; Coates, A. J.

2004-11-01

We investigate the circumstances required for aircrew and passengers to experience an increased radiation exposure rate from a solar energetic particle (SEP) event occurring during a flight. The effects of the 14 July 2000 National Oceanic and Atmospheric Administration S3 class SEP event are examined using ground-based and satellite measurements together with coincident measurements made using a tissue equivalent proportional counter (TEPC) on board a Virgin Atlantic Airways flight from London Heathrow to Hong Kong. In this paper we present the first measurements made during a SEP event using a TEPC at flight altitudes. Our results indicate that there were no increased radiation levels detected during the flight due to the SEPs, but the measurements agreed well with the CARI-6 model calculations made using a heliocentric potential value derived immediately prior to the SEP event. In addition, a prolonged increase in the >85 MeV particle flux is observed for up to 2 days after the SEP onset by the SAMPEX spacecraft at latitudes >55°.

Size Distributions of Solar Flares and Solar Energetic Particle Events

NASA Technical Reports Server (NTRS)

Cliver, E. W.; Ling, A. G.; Belov, A.; Yashiro, S.

2012-01-01

We suggest that the flatter size distribution of solar energetic proton (SEP) events relative to that of flare soft X-ray (SXR) events is primarily due to the fact that SEP flares are an energetic subset of all flares. Flares associated with gradual SEP events are characteristically accompanied by fast (much > 1000 km/s) coronal mass ejections (CMEs) that drive coronal/interplanetary shock waves. For the 1996-2005 interval, the slopes (alpha values) of power-law size distributions of the peak 1-8 Angs fluxes of SXR flares associated with (a) >10 MeV SEP events (with peak fluxes much > 1 pr/sq cm/s/sr) and (b) fast CMEs were approx 1.3-1.4 compared to approx 1.2 for the peak proton fluxes of >10 MeV SEP events and approx 2 for the peak 1-8 Angs fluxes of all SXR flares. The difference of approx 0.15 between the slopes of the distributions of SEP events and SEP SXR flares is consistent with the observed variation of SEP event peak flux with SXR peak flux.

Energetic Particles in the Inner Heliosphere

NASA Astrophysics Data System (ADS)

Malandraki, Olga

2016-07-01

Solar Energetic Particle (SEP) events are a key ingredient of Solar-Terrestrial Physics both for fundamental research and space weather applications. SEP events are the defining component of solar radiation storms, contribute to radio blackouts in polar regions and are related to many of the fastest Coronal Mass Ejections (CMEs) driving major geomagnetic storms. In addition to CMEs, SEPs are also related to flares. In this work, the current state of knowledge on the SEP field will be reviewed. Key issues to be covered and discussed include: the current understanding of the origin, acceleration and transport processes of SEPs at the Sun and in the inner heliosphere, lessons learned from multi-spacecraft SEP observations, statistical quantification of the comparison of solar events and SEP events of the current solar cycle 24 with previous solar cycles, causes of the solar-cycle variations in SEP fluencies and composition, theoretical work and current SEP acceleration models. Furthermore, the outstanding issues that constitute a knowledge gap in the field will be presented and discussed, as well as future directions and expected advances from the observational and modeling perspective, also in view of the unique observations provided by the upcoming Solar Orbiter and Solar Probe Plus missions. Acknowledgement: This project has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement No 637324.

Relationship between Socioeconomic Position and Suicide Attempts among the Korean Adolescents

PubMed Central

2014-01-01

This study explored the relationship of the subjective socioeconomic position (SEP) as well as the objective SEP with the rate of suicide attempts in 74,186 adolescents from the 2012 Korea Youth Risk Behavior Web-based Survey (KYRBS). The SEP was measured by the Family Affluence Scale (FAS) and the self-rated household economic status. The low perceived SEP for either the high or low FAS score was related to the elevated likelihood of suicide attempts in both genders. As compared with the adolescents in both the high level of perceived SEP and FAS score after adjusting for other confounding factors, the middle school students were more likely to attempt suicide in both low level of perceived SEP and FAS score (OR, 1.81; 95% CI, 1.18-2.78 for boys, OR, 1.46; 95% CI, 1.13-1.90 for girls). The high school students were more likely to attempt suicide in the low perceived SEP and high FAS score (OR, 1.44; 95% CI, 1.14-1.81 for boys, OR, 1.29; 95% CI, 1.07-1.56 for girls). In conclusion, the relationship of subjective SEP is important in suicide attempts as much as objective SEP and far more important in the high school students. PMID:25246749

Space Earthquake Perturbation Simulation (SEPS) an application based on Geant4 tools to model and simulate the interaction between the Earthquake and the particle trapped on the Van Allen belt

NASA Astrophysics Data System (ADS)

Ambroglini, Filippo; Jerome Burger, William; Battiston, Roberto; Vitale, Vincenzo; Zhang, Yu

2014-05-01

During last decades, few space experiments revealed anomalous bursts of charged particles, mainly electrons with energy larger than few MeV. A possible source of these bursts are the low-frequency seismo-electromagnetic emissions, which can cause the precipitation of the electrons from the lower boundary of their inner belt. Studies of these bursts reported also a short-term pre-seismic excess. Starting from simulation tools traditionally used on high energy physics we developed a dedicated application SEPS (Space Perturbation Earthquake Simulation), based on the Geant4 tool and PLANETOCOSMICS program, able to model and simulate the electromagnetic interaction between the earthquake and the particles trapped in the inner Van Allen belt. With SEPS one can study the transport of particles trapped in the Van Allen belts through the Earth's magnetic field also taking into account possible interactions with the Earth's atmosphere. SEPS provides the possibility of: testing different models of interaction between electromagnetic waves and trapped particles, defining the mechanism of interaction as also shaping the area in which this takes place,assessing the effects of perturbations in the magnetic field on the particles path, performing back-tracking analysis and also modelling the interaction with electric fields. SEPS is in advanced development stage, so that it could be already exploited to test in details the results of correlation analysis between particle bursts and earthquakes based on NOAA and SAMPEX data. The test was performed both with a full simulation analysis, (tracing from the position of the earthquake and going to see if there were paths compatible with the burst revealed) and with a back-tracking analysis (tracing from the burst detection point and checking the compatibility with the position of associated earthquake).

Correlation Analyses Between the Characteristic Times of Gradual Solar Energetic Particle Events and the Properties of Associated Coronal Mass Ejections

NASA Astrophysics Data System (ADS)

Pan, Z. H.; Wang, C. B.; Wang, Yuming; Xue, X. H.

2011-06-01

It is generally believed that gradual solar energetic particles (SEPs) are accelerated by shocks associated with coronal mass ejections (CMEs). Using an ice-cream cone model, the radial speed and angular width of 95 CMEs associated with SEP events during 1998 - 2002 are calculated from SOHO/LASCO observations. Then, we investigate the relationships between the kinematic properties of these CMEs and the characteristic times of the intensity-time profile of their accompanied SEP events observed at 1 AU. These characteristic times of SEP are i) the onset time from the accompanying CME eruption at the Sun to the SEP arrival at 1 AU, ii) the rise time from the SEP onset to the time when the SEP intensity is one-half of peak intensity, and iii) the duration over which the SEP intensity is within a factor of two of the peak intensity. It is found that the onset time has neither significant correlation with the radial speed nor with the angular width of the accompanying CME. For events that are poorly connected to the Earth, the SEP rise time and duration have no significant correlation with the radial speed and angular width of the associated CMEs. However, for events that are magnetically well connected to the Earth, the SEP rise time and duration have significantly positive correlations with the radial speed and angular width of the associated CMEs. This indicates that a CME event with wider angular width and higher speed may more easily drive a strong and wide shock near to the Earth-connected interplanetary magnetic field lines, may trap and accelerate particles for a longer time, and may lead to longer rise time and duration of the ensuing SEP event.

The Dependence of Characteristic Times of Gradual SEP Events on Their Associated CME Properties

NASA Astrophysics Data System (ADS)

Pan, Z. H.; Wang, C. B.; Xue, X. H.; Wang, Y. M.

It is generally believed that coronal mass ejections CMEs are the drivers of shocks that accelerate gradual solar energetic particles SEPs One might expect that the characteristics of the SEP intensity time profiles observed at 1 AU are determined by properties of the associated CMEs such as the radial speed and the angular width Recently Kahler statistically investigated the characteristic times of gradual SEP events observed from 1998-2002 and their associated coronal mass ejection properties Astrophys J 628 1014--1022 2005 Three characteristic times of gradual SEP events are determined as functions of solar source longitude 1 T 0 the time from associated CME launch to SEP onset at 1 AU 2 T R the rise time from SEP onset to the time when the SEP intensity is a factor of 2 below peak intensity and 3 T D the duration over which the SEP intensity is within a factor of 2 of the peak intensity However in his study the CME speeds and angular widths are directly taken from the LASCO CME catalog In this study we analyze the radial speeds and the angular widths of CMEs by an ice-cream cone model and re-investigate their correlationships with the characteristic times of the corresponding SEP events We find T R and T D are significantly correlated with radial speed for SEP events in the best-connected longitude range and there is no correlation between T 0 and CME radial speed and angular width which is consistent with Kahler s results On the other hand it s found that T R and T D are also have

Life-course origins of social inequalities in adult immune cell markers of inflammation in a developing southern Chinese population: the Guangzhou Biobank Cohort Study.

PubMed

West, Douglas A; Leung, Gabriel M; Jiang, Chao Q; Elwell-Sutton, Timothy M; Zhang, Wei S; Lam, Tai H; Cheng, Kar K; Schooling, C Mary

2012-04-03

Socioeconomic position (SEP) throughout life is associated with cardiovascular disease, though the mechanisms linking these two are unclear. It is also unclear whether there are critical periods in the life course when exposure to better socioeconomic conditions confers advantages or whether SEP exposures accumulate across the whole life course. Inflammation may be a mechanism linking socioeconomic position (SEP) with cardiovascular disease. In a large sample of older residents of Guangzhou, in southern China, we examined the association of life course SEP with inflammation. In baseline data on 9,981 adults (≥ 50 years old) from the Guangzhou Biobank Cohort Study (2006-08), we used multivariable linear regression and model fit to assess the associations of life course SEP at four stages (childhood, early adult, late adult and current) with white blood, granulocyte and lymphocyte cell counts. A model including SEP at all four life stages best explained the association of life course SEP with white blood and granulocyte cell count for men and women, with early adult SEP (education) making the largest contribution. A critical period model best explained the association of life course SEP with lymphocyte count, with sex-specific associations. Early adult SEP was negatively associated with lymphocytes for women. Low SEP throughout life may negatively impact late adult immune-inflammatory status. However, some aspects of immune-inflammatory status may be sensitive to earlier exposures, with sex-specific associations. The findings were compatible with the hypothesis that in a developing population, upregulation of the gonadotropic axis with economic development may obscure the normally protective effects of social advantage for men.

Association of Inflammatory and Non-Inflammatory Breast Cancer with Socioeconomic Characteristics in the Surveillance, Epidemiology, and End Results Database, 2000–2007

PubMed Central

Schlichting, Jennifer A.; Soliman, Amr S.; Schairer, Catherine; Banerjee, Mousumi; Rozek, Laura S.; Schottenfeld, David; Harford, Joe B.; Merajver, Sofia D.

2011-01-01

Background Inflammatory breast cancer (IBC) is a rare and highly aggressive form of primary breast cancer. Little is known regarding risk factors for IBC, specifically the association with socioeconomic position (SEP). Methods The association between breast cancer type (IBC vs. non-IBC) with county-level SEP in the Surveillance, Epidemiology, and End Results database for cases diagnosed from 2000–2007 was examined. County-level SEP characteristics included metropolitan vs. non- metropolitan residence, percent below the poverty level, percent less than high school graduate,and an index combining the poverty and high school variables. IBC and non-IBC age-adjusted incidence rates (IRs) were calculated, stratified on SEP and race/ethnicity. The odds of IBC vs. non-IBC given a particular SEP characteristic, adjusting for age and race/ethnicity, was examined through fitting of hierarchical logistic regression models (HLMs). Results IRs for IBC generally increased as SEP decreased, while the opposite was found for non-IBC. HLM results showed low SEP is associated with higher odds of IBC: Highest (≥ 20%) vs. lowest (<10%) persons below the poverty level Odds Ratio (95% Confidence Interval) = 1.25 (1.09–1.43); Highest (>28.76%) vs. lowest (≤15.99%) persons less than high school graduate = 1.25 (1.10–1.42); Low SEP as measured by poverty-high school index vs. high SEP = 1.26 (1.11–1.44). Conclusion Overall breast cancer has been found to be positively associated with SEP, whereas in this analysis IBC was associated with decreasing SEP. Impact Studies focused on understanding the disparity in IBC incidence, as well as interventions to eliminate these differences are needed. PMID:22028401

Socioeconomic Position Is Associated With Carotid Intima-Media Thickness in Mid-Childhood: The Longitudinal Study of Australian Children.

PubMed

Liu, Richard S; Mensah, Fiona K; Carlin, John; Edwards, Ben; Ranganathan, Sarath; Cheung, Michael; Dwyer, Terence; Saffery, Richard; Magnussen, Costan G; Juonala, Markus; Wake, Melissa; Burgner, David P

2017-08-09

Lower socioeconomic position (SEP) predicts higher cardiovascular risk in adults. Few studies differentiate between neighborhood and family SEP or have repeated measures through childhood, which would inform understanding of potential mechanisms and the timing of interventions. We investigated whether neighborhood and family SEP, measured biennially from ages 0 to 1 year onward, was associated with carotid intima-media thickness (IMT) at ages 11 to 12 years. Data were obtained from 1477 families participating in the Child Health CheckPoint study, nested within the Longitudinal Study of Australian Children. Disadvantaged family and neighborhood SEP was cross-sectionally associated with thicker maximum carotid IMT in separate univariable linear regression models. Associations with family SEP were not attenuated in multivariable analyses, and associations with neighborhood SEP were attenuated only in models adjusted for family SEP. The difference in maximum carotid IMT between the highest and lowest family SEP quartile measured at ages 10 to 11 years was 10.7 μm (95% CI, 3.4-18.0; P =0.004), adjusted for age, sex, pubertal status, passive smoking exposure, body mass index, blood pressure, and arterial lumen diameter. In longitudinal analyses, family SEP measured as early as age 2 to 3 years was associated with maximum carotid IMT at ages 11 to 12 years (difference between highest and lowest quartile: 8.5 μm; 95% CI, 1.3-15.8; P =0.02). No associations were observed between SEP and mean carotid IMT. We report a robust association between lower SEP in early childhood and carotid IMT in mid-childhood. Further investigation of mechanisms may inform pediatric cardiovascular risk assessment and prevention strategies. © 2017 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley.

Race, life course socioeconomic position, racial discrimination, depressive symptoms and self-rated health.

PubMed

Hudson, Darrell L; Puterman, Eli; Bibbins-Domingo, Kirsten; Matthews, Karen A; Adler, Nancy E

2013-11-01

Greater levels of socioeconomic position (SEP) are generally associated with better health. However results from previous studies vary across race/ethnicity and health outcomes. Further, the majority of previous studies do not account for the effects of life course SEP on health nor the effects of racial discrimination, which could moderate the effects of SEP on health. Using data from the Coronary Artery Risk Development in Young Adults (CARDIA) study, we examined the relationship between a life course SEP measure on depressive symptoms and self-rated health. A life course SEP was constructed for each participant, using a framework that included parental education and occupation along with respondents' highest level of education and occupation. Interaction terms were created between life course SEP and racial discrimination to determine whether the association between SEP and health was moderated by experiences of racial discrimination. Analyses revealed that higher levels of life course SEP were inversely related to depressive symptoms. Greater life course SEP was positively associated with favorable self-rated health. Racial discrimination was associated with more depressive symptoms and poorer self-rated health. Analyses indicated a significant interaction between life course SEP and racial discrimination on depressive symptoms in the full sample. This suggested that for respondents with greater levels of SEP, racial discrimination was associated with reports of more depressive symptoms. Future research efforts should be made to examine whether individuals' perceptions and experiences of racial discrimination at the interpersonal and structural levels limits their ability to acquire human capital as well as their advancement in education and occupational status. Copyright © 2013 Elsevier Ltd. All rights reserved.

The effect of turbulence strength on meandering field lines and Solar Energetic Particle event extents

NASA Astrophysics Data System (ADS)

Laitinen, Timo; Effenberger, Frederic; Kopp, Andreas; Dalla, Silvia

2018-02-01

Insights into the processes of Solar Energetic Particle (SEP) propagation are essential for understanding how solar eruptions affect the radiation environment of near-Earth space. SEP propagation is influenced by turbulent magnetic fields in the solar wind, resulting in stochastic transport of the particles from their acceleration site to Earth. While the conventional approach for SEP modelling focuses mainly on the transport of particles along the mean Parker spiral magnetic field, multi-spacecraft observations suggest that the cross-field propagation shapes the SEP fluxes at Earth strongly. However, adding cross-field transport of SEPs as spatial diffusion has been shown to be insufficient in modelling the SEP events without use of unrealistically large cross-field diffusion coefficients. Recently, Laitinen et al. [ApJL 773 (2013b); A&A 591 (2016)] demonstrated that the early-time propagation of energetic particles across the mean field direction in turbulent fields is not diffusive, with the particles propagating along meandering field lines. This early-time transport mode results in fast access of the particles across the mean field direction, in agreement with the SEP observations. In this work, we study the propagation of SEPs within the new transport paradigm, and demonstrate the significance of turbulence strength on the evolution of the SEP radiation environment near Earth. We calculate the transport parameters consistently using a turbulence transport model, parametrised by the SEP parallel scattering mean free path at 1 AU, λ∥*, and show that the parallel and cross-field transport are connected, with conditions resulting in slow parallel transport corresponding to wider events. We find a scaling σφ,max∝(1/λ∥*)1/4 for the Gaussian fitting of the longitudinal distribution of maximum intensities. The longitudes with highest intensities are shifted towards the west for strong scattering conditions. Our results emphasise the importance of understanding both the SEP transport and the interplanetary turbulence conditions for modelling and predicting the SEP radiation environment at Earth.

Associations of life course socioeconomic position and job stress with carotid intima-media thickness. The Brazilian Longitudinal Study of Adult Health (ELSA-Brasil).

PubMed

Camelo, Lidyane V; Giatti, Luana; Chor, Dóra; Griep, Rosane Härter; Benseñor, Isabela M; Santos, Itamar S; Kawachi, Ichiro; Barreto, Sandhi Maria

2015-09-01

The association between life course socioeconomic position (SEP) and subclinical atherosclerosis is not consistent across studies. Socioeconomic adversities early in life are related to an increased probability of a low occupational grade and more stressful jobs in adulthood. However, the role of job stress in explaining the life course social gradient in subclinical atherosclerosis is unknown. To examine whether life course SEP is associated with carotid intima-media thickness (IMT) and to investigate whether this association is partially mediated by job stress. This study used baseline data (2008-2010) for 8806 current workers from ELSA-Brasil. Maternal education, social class of first occupation and social class of current occupation were used to evaluate childhood, youth and adulthood SEP, respectively. Accumulation of risk across the life course was also evaluated. Job stress was assessed by the Swedish Demand-Control-Support Questionnaire. Directed acyclic graph and linear regression models were used. Low childhood SEP was associated with increased IMT only in women, but low youth and adulthood SEP were associated with higher IMT in both genders. The simultaneous adjustment for all SEP indicators showed that only adulthood SEP continued to be associated with IMT. However, higher IMT values were observed among men and women sequentially exposed to low SEP in more than one period of life. High-strain jobs and low job control were not associated with IMT independent of SEP. Our results support a model of the cumulative effects of exposures to SEP across the life span because the highest IMT values were observed in individuals sequentially exposed to low SEP in more than one period of life. We did not find that job stress explained the association between life course SEP and IMT, suggesting that strategies to address socioeconomic inequalities in CVD should target additional steps beyond reducing job stress. Copyright © 2015 Elsevier Ltd. All rights reserved.

Advanced Visualization and Interactive Display Rapid Innovation and Discovery Evaluation Research (VISRIDER) Program Task 6: Point Cloud Visualization Techniques for Desktop and Web Platforms

DTIC Science & Technology

2017-04-01

ADVANCED VISUALIZATION AND INTERACTIVE DISPLAY RAPID INNOVATION AND DISCOVERY EVALUATION RESEARCH (VISRIDER) PROGRAM TASK 6: POINT CLOUD...To) OCT 2013 – SEP 2014 4. TITLE AND SUBTITLE ADVANCED VISUALIZATION AND INTERACTIVE DISPLAY RAPID INNOVATION AND DISCOVERY EVALUATION RESEARCH...various point cloud visualization techniques for viewing large scale LiDAR datasets. Evaluate their potential use for thick client desktop platforms

Space Propulsion Technology Program Overview

NASA Technical Reports Server (NTRS)

Escher, William J. D.

1991-01-01

The topics presented are covered in viewgraph form. Focused program elements are: (1) transportation systems, which include earth-to-orbit propulsion, commercial vehicle propulsion, auxiliary propulsion, advanced cryogenic engines, cryogenic fluid systems, nuclear thermal propulsion, and nuclear electric propulsion; (2) space platforms, which include spacecraft on-board propulsion, and station keeping propulsion; and (3) technology flight experiments, which include cryogenic orbital N2 experiment (CONE), SEPS flight experiment, and cryogenic orbital H2 experiment (COHE).

Extra-Zodiacal-Cloud Astronomy via Solar Electric Propulsion

NASA Technical Reports Server (NTRS)

Benson, Scott W.; Falck, Robert D.; Oleson, Steven R.; Greenhouse, Matthew A.; Kruk, Jeffrey W.; Gardner, Jonathan P.; Thronson, Harley A.; Vaughn, Frank J.; Fixsen, Dale J.

2011-01-01

Solar electric propulsion (SEP) is often considered as primary propulsion for robotic planetary missions, providing the opportunity to deliver more payload mass to difficult, high-delta-velocity destinations. However, SEP application to astrophysics has not been well studied. This research identifies and assesses a new application of SEP as primary propulsion for low-cost high-performance robotic astrophysics missions. The performance of an optical/infrared space observatory in Earth orbit or at the Sun-Earth L2 point (SEL2) is limited by background emission from the Zodiacal dust cloud that has a disk morphology along the ecliptic plane. By delivering an observatory to a inclined heliocentric orbit, most of this background emission can be avoided, resulting in a very substantial increase in science performance. This advantage enabled by SEP allows a small-aperture telescope to rival the performance of much larger telescopes located at SEL2. In this paper, we describe a novel mission architecture in which SEP technology is used to enable unprecedented telescope sensitivity performance per unit collecting area. This extra-zodiacal mission architecture will enable a new class of high-performance, short-development time, Explorer missions whose sensitivity and survey speed can rival flagship-class SEL2 facilities, thus providing new programmatic flexibility for NASA's astronomy mission portfolio. A mission concept study was conducted to evaluate this application of SEP. Trajectory analyses determined that a 700 kg-class science payload could be delivered in just over 2 years to a 2 AU mission orbit inclined 15 to the ecliptic using a 13 kW-class NASA's Evolutionary Xenon Thruster (NEXT) SEP system. A mission architecture trade resulted in a SEP stage architecture, in which the science spacecraft separates from the stage after delivery to the mission orbit. The SEP stage and science spacecraft concepts were defined in collaborative engineering environment studies. The SEP stage architecture approach offers benefits beyond a single astrophysics mission. A variety of low-cost astrophysics missions could employ a standard SEP stage to achieve substantial science benefit. This paper describes the results of this study in detail, including trajectory analysis, spacecraft concept definition, description of telescope/instrument benefits, and application of the resulting SEP stage to other missions. In addition, the benefits of cooperative development and use of the SEP stage, in conjunction with a SEP flight demonstration mission currently in definition at NASA, are considered.

Association of Lower Socioeconomic Position in Pregnancy with Lower Diurnal Cortisol Production and Lower Birthweight in Male Infants.

PubMed

Bublitz, Margaret H; Vergara-Lopez, Chrystal; O'Reilly Treter, Maggie; Stroud, Laura R

2016-02-01

Low maternal socioeconomic position (SEP) has been associated with adverse neonatal outcomes, including preterm birth, low birthweight, intrauterine growth restriction, and infant mortality. A key biological mechanism that has been proposed to explain this association is hypothalamic-pituitary-adrenal (HPA) activity, yet the association between SEP and HPA activity in pregnancy has received little attention. In this study we aimed to examine the associations between SEP and 2 forms of maternal cortisol regulation-diurnal slope and wakening response-across pregnancy. Furthermore, we aimed to assess whether these associations differed by the sex of the fetus. A total of 217 pregnant women aged 18 to 40 years with singleton pregnancies participated. Women were excluded from participating if they were aged <18 or >40 years and if they were at risk for maternal or obstetric complications. Women provided information on socioeconomic characteristics of adults contributing to the participants' household to compute a Hollingshead Four Factor Index of Social Status score of SEP. Women provided salivary cortisol samples on awakening, 30 minutes after wakeup, and at bedtime, at 3 times over pregnancy and once 30 days postpartum to calculate the diurnal slope and cortisol awakening response (CAR). Using linear regression analyses, we examined the relationships between maternal SEP and maternal diurnal slope and CAR. We explored the relationships between maternal SEP and cortisol by fetal sex using linear regression analyses. We also explored links between maternal SEP, maternal cortisol, and infant birth outcomes. Women of lower SEP displayed smaller awakening responses and less change over the day compared with women of higher SEP. SEP was significantly associated with attenuated diurnal slope only among women carrying female fetuses, whereas for CAR, the association between SEP and attenuated CAR was significant only for women carrying male fetuses. Lower SEP was associated with decreased birthweight, and this association was partially explained by maternal HPA activity in pregnancy. Women of low SEP displayed attenuated HPA activity across the perinatal period, and patterns varied by fetal sex and cortisol metric. Findings are in need of replication. More research is needed to understand the links between SEP, HPA activity, and neonatal health. Copyright © 2016 Elsevier HS Journals, Inc. All rights reserved.

Echo-Planar Imaging-Based, J-Resolved Spectroscopic Imaging for Improved Metabolite Detection in Prostate Cancer

DTIC Science & Technology

2016-12-01

Final 3. DATES COVERED 30Sep2011 - 29Sep2016 4 . TITLE AND SUBTITLE 5a. CONTRACT NUMBER W81XWH-11-1-0248 5b. GRANT NUMBER 5c. PROGRAM ELEMENT...Spectroscopic Imaging for Improved Metabolite Detection in Prostate Cancer Table of Contents Page Introduction…………………………………………………………….………..….. 4 Body... 4 Key Research Accomplishments………………………………………….…….. 10 Reportable Outcomes………………………………………………………………10 Conclusion

Gulf War Illness as a Brain Autoimmune Disorder

DTIC Science & Technology

2016-10-01

FORM TO THE ABOVE ADDRESS. 1. REPORT DATE October 2016 2. REPORT TYPE Annual 3 . DATES COVERED 4 Sep 2015 - 3 Sep 2016 4. TITLE AND SUBTITLE 5a...0520 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d. PROJECT NUMBER Apostolos Georgopoulos, MD, PhD 5e. TASK NUMBER E-Mail: omega @umn.edu 5f. WORK UNIT...Keywords……………………………………………………………. 1 3 . Accomplishments………..…………………………………………... 1 4. Impact…………………………...…………………………………… 2 5. Changes

Application of Solar-Electric Propulsion to Robotic and Human Missions in Near-Earth Space

NASA Technical Reports Server (NTRS)

Woodcock, Gordon R.; Dankanich, John

2011-01-01

Interest in applications of solar electric propulsion (SEP) is increasing. Application of SEP technology is favored when: (1) the mission is compatible with low-thrust propulsion, (2) the mission needs high total delta V such that chemical propulsion is disadvantaged; and (3) performance enhancement is needed. If all such opportunities for future missions are considered, many uses of SEP are likely. Representative missions are surveyed and several SEP applications selected for analysis, including orbit raising, lunar science, lunar exploration, lunar exploitation, planetary science, and planetary exploration. These missions span SEP power range from 10s of kWe to several MWe. Modes of use and benefits are described, and potential SEP evolution is discussed.

Application of Solar-Electric Propulsion to Robotic and Human Missions in Near-Earth Space

NASA Technical Reports Server (NTRS)

Woodcock, Gordon R.; Dankanich, John

2006-01-01

Interest in applications of solar electric propulsion (SEP) is increasing. Application of SEP technology is favored when: (1) the mission is compatible with low-thrust propulsion, (2) the mission needs high total delta V such that chemical propulsion is disadvantaged; and (3) performance enhancement is needed. If all such opportunities for future missions are considered, many uses of SEP are likely. Representative missions are surveyed and several SEP applications selected for analysis, including orbit raising, lunar science, lunar exploration, lunar exploitation, planetary science, and planetary exploration. These missions span SEP power range from 10s of kWe to several MWe. Modes of use and benefits are described, and potential SEP evolution is discussed.

Development of FT-NIR Models for the Simultaneous Estimation of Chlorophyll and Nitrogen Content in Fresh Apple (Malus Domestica) Leaves

PubMed Central

Tamburini, Elena; Ferrari, Giuseppe; Marchetti, Maria Gabriella; Pedrini, Paola; Ferro, Sergio

2015-01-01

Agricultural practices determine the level of food production and, to great extent, the state of the global environment. During the last decades, the indiscriminate recourse to fertilizers as well as the nitrogen losses from land application have been recognized as serious issues of modern agriculture, globally contributing to nitrate pollution. The development of a reliable Near-Infra-Red Spectroscopy (NIRS)-based method, for the simultaneous monitoring of nitrogen and chlorophyll in fresh apple (Malus domestica) leaves, was investigated on a set of 133 samples, with the aim of estimating the nutritional and physiological status of trees, in real time, cheaply and non-destructively. By means of a FT (Fourier Transform)-NIR instrument, Partial Least Squares (PLS) regression models were developed, spanning a concentration range of 0.577%–0.817% for the total Kjeldahl nitrogen (TKN) content (R2 = 0.983; SEC = 0.012; SEP = 0.028), and of 1.534–2.372 mg/g for the total chlorophyll content (R2 = 0.941; SEC = 0.132; SEP = 0.162). Chlorophyll-a and chlorophyll-b contents were also evaluated (R2 = 0.913; SEC = 0.076; SEP = 0.101 and R2 = 0.899; SEC = 0.059; SEP = 0.101, respectively). All calibration models were validated by means of 47 independent samples. The NIR approach allows a rapid evaluation of the nitrogen and chlorophyll contents, and may represent a useful tool for determining nutritional and physiological status of plants, in order to allow a correction of nutrition programs during the season. PMID:25629703

The impact of nutritional policy on socioeconomic disparity in the unhealthy food intake among Korean adolescents.

PubMed

Kim, Kirang; Park, Sun Min; Oh, Kyung Won

2013-12-01

The objectives of this study were to examine the trend in unhealthy food intake by socioeconomic position (SEP) and to determine whether the government's nutritional policies affect socioeconomic disparity in the food intake among adolescents. Data were from the six independent cross-sectional survey data (2006-2011) of Korea Youth Risk Behavior Web-based Survey and included 445,287 subjects aged 12-18 years. The unhealthy food intake was assessed by food frequency intake and SEP was evaluated with the family affluence scale. We observed that unhealthy food intakes decreased through the years, showing the apparent decline when nutritional policies focusing on the restriction of unhealthy foods were implemented, and the trend was all same in the different SEP groups. The pattern of unhealthy food intakes by SEP has changed before and after implementation of the policies. The intakes of carbonated beverages, fast food, and confectioneries were higher in the higher SEP group before implementation of the policies but the difference was not shown after implementation of the policies. The intake of instant noodles was consistently higher in the lower SEP group. The risk of frequent consumption of unhealthy foods was generally more decreased through the years in the higher SEP group than the lower SEP group. In conclusion, this study found the positive effect of nutritional policy on unhealthy food intake among adolescents and the high SEP group appeared to undergo greater desirable changes in dietary behaviors after implementation of nutritional policies than the low SEP group. Copyright © 2013 Elsevier Ltd. All rights reserved.

Preparation of red blood cell concentrates and plasma units from whole blood held overnight using a hollow-fibre separation system.

PubMed

Johnson, L; Kwok, M; Marks, D C

2015-02-01

The ErySep system represents an alternative to centrifuge-based whole blood (WB) separation, using gravity and filtration through hollow-fibres (0·2 µm pore size) to produce red blood cell (RBC) and plasma components. The aim of this study was to characterise the quality of ErySep RBC and plasma units compared with standard products from WB held overnight. Two ABO-compatible WB units (n = 24) were pooled and split to produce matched products. One of the WB units was separated into components using the ErySep system (ErySep; n = 12), whereas the other units were separated by centrifugation (control; n = 12). RBC units were stored at 2-6 °C and assessed for in vitro quality over 42 days of storage. Plasma was frozen at -30 °C and tested upon thawing. Processing WB with the ErySep system took longer than controls. The ErySep RBC units were of an appropriate volume (307 ± 17 mL) and contained sufficient Hb (50 ± 2 g unit(-1) ). ErySep RBC components contained more microparticles relative to controls at expiry. The plasma volume, total protein, coagulation factor activity (fibrinogen, FV, FVIII) and number of microparticles was lower in the ErySep units compared with controls. Following overnight hold of WB, the ErySep system was capable of producing RBC components that met specifications. However, the ErySep plasma components did not meet quality specifications. © 2015 British Blood Transfusion Society.

Properties of Coronal Shocks at the Origin of SEP events Observed by Only One Single Spacecraft

NASA Astrophysics Data System (ADS)

Lario, D.; Kwon, R.

2017-12-01

The simultaneous observation of solar energetic particle (SEP) events by multiple spacecraft distributed in the interplanetary medium depends not only on the spatial separation among the different spacecraft, but also on the properties of the particle sources and the characteristics of the SEP transport in interplanetary space. Among the SEP events observed by STEREO-A, STEREO-B and/or near-Earth spacecraft during solar cycle 24, we select SEP events observed by a single spacecraft (specifically, the SEP events observed only by near-Earth spacecraft on 2012 April 5, 2011 September 4, and 2013 August 17). We analyze whether the properties of the coronal shock associated with the origin of the events (as seen in extreme-ultraviolet and white-light coronal images) differ from those associated with SEP events observed by two or three spacecraft. For the selected events we find that the associated CMEs are, in general, narrower than those associated with SEP events observed by two or three spacecraft. The confined extension of the parent coronal shock and the absence of magnetic connection between distant spacecraft and the regions of the expanding coronal shock able to efficiently accelerate SEPs seem to be the conditions leading to intense SEP events observed only over narrow regions of interplanetary space by spacecraft magnetically connected to regions close to the parent eruption site. Weak and gradual intensity increases observed in extended regions of space might involve transport processes and/or later connections established with interplanetary shocks. Systematic analyses of a larger number of events are required before drawing firm conclusions.

JPRS Report East Europe.

DTIC Science & Technology

1990-11-26

Class Creation Necessary for Success of Reforms [LIDOVE NOVINY18 Sep] 21 Problem of Increasing Food Inventories Viewed [ZEMEDELSKE NOVINY 29 Sep...KULGAZDASAG Sep] 27 Industry: Difficulties Predicted; Trends, Problems Analyzed [FIGYELO 11 Oct] 37 Semiannual Investment Report [FIGYELO 13 Sep...MLADA FRONTA] And is not the problem of Czech politics connected with the nonexistence of Czech con- sciousness and self-confidence? [Battek] It

Characterization of co-products from producing ethanol by sequential extraction processing of corn

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hojilla-Evangelista, M.P.; Johnson, L.A.; Pometto, A.L. III

1996-12-31

Sequential Extraction Processing (SEP) is a new process for ethanol production that has potential to produce more valuable co-products than alternative processes. Previous work determined the yields of oil and protein and evaluated their chemical and functional properties. The properties of the crude fiber and spent solids, however, have yet to be studied. This research was conducted to evaluate the potential of SEP corn fiber to increase ethanol conversion and as replacement for gum arabic, and evaluate the potential of SEP starch and fiber to be fermented to ethanol. SEP hemicellulose from crude fiber was readily dispersible in water andmore » its solution (5%) gave low viscosity despite having high solids content. These properties indicated potential utilization as stabilizers, thickeners, and adhesive for coatings and batters in food and industrial products. Enzyme hydrolysis studies and batch fermentation of SEP starch/fiber indicated that SEP crude fiber was more readily accessible to the action of cellulases. More ethanol (about 10%) was produced from the fermentation of SEP starch/fiber than from undegermed or degermed soft dent corn, particularly when the hemicellulose fraction was absent from the SEP fiber.« less

Temporal trends in BMI in Argentina by socio-economic position and province-level economic development, 2005-2009.

PubMed

Christine, Paul J; Diez Roux, Ana V; Wing, Jeffrey J; Alazraqui, Marcio; Spinelli, Hugo

2015-04-01

We investigated temporal trends in BMI, and assessed hypothesized predictors of trends including socio-economic position (SEP) and province-level economic development, in Argentina. Using multivariable linear regression, we evaluated cross-sectional patterning and temporal trends in BMI and examined heterogeneity in these associations by SEP and province-level economic development with nationally representative samples from Argentina in 2005 and 2009. We calculated mean annual changes in BMI for men and women to assess secular trends. Women, but not men, exhibited a strong cross-sectional inverse association between SEP and BMI, with the lowest-SEP women having an average BMI 2.55 kg/m(2) greater than the highest-SEP women. Analysis of trends revealed a mean annual increase in BMI of 0.19 kg/m(2) and 0.15 kg/m(2) for women and men, respectively, with slightly greater increases occurring in provinces with greater economic growth. No significant heterogeneity in trends existed by individual SEP. BMI is increasing rapidly over time in Argentina irrespective of various sociodemographic characteristics. Higher BMI remains more common in women of lower SEP compared with those of higher SEP.

Time Variations in Forecasts and Occurrences of Large Solar Energetic Particle Events

NASA Astrophysics Data System (ADS)

Kahler, S. W.

2015-12-01

The onsets and development of large solar energetic (E > 10 MeV) particle (SEP) events have been characterized in many studies. The statistics of SEP event onset delay times from associated solar flares and coronal mass ejections (CMEs), which depend on solar source longitudes, can be used to provide better predictions of whether a SEP event will occur following a large flare or fast CME. In addition, size distributions of peak SEP event intensities provide a means for a probabilistic forecast of peak intensities attained in observed SEP increases. SEP event peak intensities have been compared with their rise and decay times for insight into the acceleration and transport processes. These two time scales are generally treated as independent parameters describing the development of a SEP event, but we can invoke an alternative two-parameter description based on the assumption that decay times exceed rise times for all events. These two parameters, from the well known Weibull distribution, provide an event description in terms of its basic shape and duration. We apply this distribution to several large SEP events and ask what the characteristic parameters and their dependence on source longitudes can tell us about the origins of these important events.

Elemental composition of solar energetic particles. Ph.D. Thesis

NASA Technical Reports Server (NTRS)

Cook, W. R., III

1981-01-01

The Low Energy Telescopes on the Voyager spacecraft are used to measure the elemental composition (2 or = Z or = 28) and energy spectra (5 to 15 MeV/nucleon) of solar energetic particles (SEPs) in seven large flare events. Four flare events are selected which have SEP abundance ratios approximately independent of energy/nucleon. The abundances for these events are compared from flare to flare and are compared to solar abundances from other sources: spectroscopy of the photosphere and corona, and solar wind measurements. The four flare average SEP composition is significantly different from the solar composition determined by photospheric spectroscopy. The average SEP composition is in agreement with solar wind abundance results and with a number of recent coronal abundance measurements. The evidence for a common depletion of oxygen in SEPs, the corona and the solar wind relative to the photosphere suggest that the SEPs originate in the corona and that both the SEPs and solar wind sample a coronal composition which is significantly and persistently different from that of the photosphere.

A Systems Analysis View of the Vietnam War: 1965-1972. Volume 11. Economics: War Costs and Inflation

DTIC Science & Technology

1975-02-01

Conflict On Great Society Programs Sep 67 4 The Cost Of Bombing North Vietnam Dec 67 8 The Bombing - Its Economic Costs Avnd Benefits To North Vietnam...current DOD program and the one for the peacetime force structure after the war. A third cost concept is reflected in the figures the Defense Department...papers will cover FY 70-71, as soon as those program budgets are ready, and will include AID, GVN, and third country costs . Total Cost . The total cost

Factors Affecting the Occurrence of Large Solar Energetic Particle Events

NASA Astrophysics Data System (ADS)

Gopalswamy, N.; Yashiro, S.; Akiyama, S.; Xie, H.; Makela, P. A.; Thakur, N.

2014-12-01

In order to understand the paucity of high-energy solar energetic particle (SEP) events in solar cycle 24, we examined all major eruptions (soft X-ray flare size ≥M5.0) on the front side of the Sun during the period from December 1, 2008 to January 31, 2014. There were 59 such eruptions that were associated with CMEs. When a flux rope was fitted to the white-light CMEs observed by SOHO and STEREO it was found that the CME sources were on the disk only for 55 eruptions. There were 16 large SEP events (proton intensity ≥10 pfu in the >10 MeV channel) detected by GOES and 4 by STEREO-B in association with these eruptions. When the CMEs were grouped according to their speeds (<1500 km/s and ≥ 1500 km/s) it was found that only three of the <1500 km/s CMEs (or 11%) were associated with large SEP events compared to 17 or (61%) of the ≥ 1500 km/s CMEs. This result confirms the importance of CME speed for SEP association. In fact there were ten other large SEP events with flare size

48 CFR 552.219-76 - Mentor Requirements and Evaluation.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Mentor Requirements and....219-76 Mentor Requirements and Evaluation. As prescribed in 519.7017(b), insert the following clause: Mentor Requirements and Evaluation (SEP 2009) (a) The purpose of the GSA Mentor-Protégé Program is for a...

Taming the Tigers: Recapturing the Acquisition Excellence of Our Planning, Programming, and Acquisition Three-Ring Circus

DTIC Science & Technology

2013-04-01

Richard de Neufville, Prof. Gautam Mukunda, Col Glenn Downing, Col Chris Garrett, Col Jim Lovell, Col Troy Thomas, Bill Castle, Mike Kalna, Carl Rehberg... Watts , Op-Ed, “Confronting Threats of Military Modernization,” Politico, 26 Sep- tember 2012. 2. Air Force Instruction 16-501, Control and

Re-Engineering the United States Marine Corps Special Education Program (SEP).

DTIC Science & Technology

1998-03-01

McDonald’s or Burger King based on personal preference. This simple decision has only two alternatives and relatively low consequences (the decision...In the example of restaurants seen above, a person would not be able to examine 2000 different franchises and select the best one in which to invest

76 FR 4911 - Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Centers of...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-27

...: Embassy Suites, 1900 Diagonal Road, Alexandria, Virginia 22314, Telephone: (703) 684-5900. Status: The... Programs, National Institute for Occupational Safety and Health, CDC, 1600 Clifton Road, NE., Mailstop P05..., has been delegated the authority to sign Federal Register notices pertaining to announcements of...

77 FR 48986 - Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Initial Review

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-15

... announced below concerns Member Conflict Review, Program Announcement (PA) 07-318, initial review. In...., and the Determination of the Director, Management Analysis and Services Office, CDC, pursuant to... evaluation of applications received in response to ``Member Conflict Review, PA 07-318.'' Contact Person for...

76 FR 52330 - Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Initial Review

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-22

... announced below concerns Member Conflict Review, Program Announcement (PA) 07-318, initial review. In...., and the Determination of the Director, Management Analysis and Services Office, CDC, pursuant to... evaluation of applications received in response to ``Member Conflict Review, PA 07-318.'' Contact Person for...

77 FR 7164 - Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Initial Review

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-10

... announced below concerns Member Conflict Review, Program Announcement (PA) 07-318, initial review. In....C., and the Determination of the Director, Management Analysis and Services Office, CDC, pursuant to... evaluation of applications received in response to ``Member Conflict Review, PA 07-318.'' Contact Person for...

78 FR 25743 - Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Initial Review

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-02

... announced below concerns Member Conflict Review, Program Announcement (PA) 07-318, initial review. In... Determination of the Director, Management Analysis and Services Office, CDC, pursuant to Public Law 92-463... applications received in response to ``Member Conflict Review, PA 07-318.'' Contact Person for More Information...

77 FR 31018 - Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Initial Review

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-24

... announced below concerns Member Conflict Review, Program Announcement (PA) 07-318, and Centers of Excellence...) and (6), Title 5 U.S.C., and the Determination of the Director, Management Analysis and Services... review, discussion, and evaluation of applications received in response to ``Member Conflict Review, PA...

Turbulence Evolution and Shock Acceleration of Solar Energetic Particles

NASA Technical Reports Server (NTRS)

Chee, Ng K.

2007-01-01

We model the effects of self-excitation/damping and shock transmission of Alfven waves on solar-energetic-particle (SEP) acceleration at a coronal-mass-ejection (CME) driven parallel shock. SEP-excited outward upstream waves speedily bootstrap acceleration. Shock transmission further raises the SEP-excited wave intensities at high wavenumbers but lowers them at low wavenumbers through wavenumber shift. Downstream, SEP excitation of inward waves and damping of outward waves tend to slow acceleration. Nevertheless, > 2000 km/s parallel shocks at approx. 3.5 solar radii can accelerate SEPs to 100 MeV in < 5 minutes.

Computer Aided Method for System Safety and Reliability Assessments

DTIC Science & Technology

2008-09-01

program between 1998 and 2003. This tool was not marketed in the public domain after the CRV program ended. The other tool is called eXpress, and it...support Government reviewed and approved analyses methodologies which can 5 then be shared with other government agencies and industry partners...Documented for B&R, UP&L, EPRI 30 DEC 80 GO IBM Version Enhanced at UCC , Dallas, Descriptors, Facility to Alter Array Sizes, Explanation of Use 1 SEP 82

Combat Support Forces (1C6C) Naval Surface Forces Requirements-based Budget Determination for Assault Craft Unit ONE

DTIC Science & Technology

2009-06-01

228,027 AUG 31,098 107,135 AUG - AUG 38,869 136,669 SEP 81,005 166,854 SEP 215,648 551,379 SEP - SEP 16,505 83,549 USS WHIPPLE (FF...Naval Supply System Command: Afloat Supply Procedures : Volume II. Retrived May 18, 2009, from Navy Storekeeper website: http://www.navystorekeeper.com

29 CFR 2520.104-48 - Alternative method of compliance for model simplified employee pensions-IRS Form 5305-SEP.

Code of Federal Regulations, 2010 CFR

2010-07-01

... employee pensions-IRS Form 5305-SEP. 2520.104-48 Section 2520.104-48 Labor Regulations Relating to Labor... compliance for model simplified employee pensions—IRS Form 5305-SEP. Under the authority of section 110 of... Security Act of 1974 in the case of a simplified employee pension (SEP) described in section 408(k) of the...

The Impact of Lifecourse Socioeconomic Position on Cardiovascular Disease Events in African Americans: The Jackson Heart Study

PubMed Central

Gebreab, Samson Y; Diez Roux, Ana V; Brenner, Allison B; Hickson, DeMarc A; Sims, Mario; Subramanyam, Malavika; Griswold, Michael E; Wyatt, Sharon B; James, Sherman A

2015-01-01

Background Few studies have examined the impact of lifecourse socioeconomic position (SEP) on cardiovascular disease (CVD) risk among African Americans. Methods and Results We used data from the Jackson Heart Study (JHS) to examine the associations of multiple measures of lifecourse SEP with CVD events in a large cohort of African Americans. During a median of 7.2-year follow-up, 362 new or recurrent CVD events occurred in a sample of 5301 participants aged 21 to 94. Childhood SEP was assessed by using mother’s education, parental home ownership, and childhood amenities. Adult SEP was assessed by using education, income, wealth, and public assistance. Adult SEP was more consistently associated with CVD risk in women than in men: age-adjusted hazard ratios for low versus high income (95% CIs), 2.46 (1.19 to 5.09) in women and 1.50 (0.87 to 2.58) in men, P for interaction=0.1244, and hazard ratio for low versus high wealth, 2.14 (1.39 to 3.29) in women and 1.06 (0.62 to 1.81) in men, P for interaction=0.0224. After simultaneous adjustment for all adult SEP measures, wealth remained a significant predictor of CVD events in women (HR=1.73 [1.04, 2.85] for low versus high). Education and public assistance were less consistently associated with CVD. Adult SEP was a stronger predictor of CVD events in younger than in older participants (HR for high versus low summary adult SEP score 3.28 [1.43, 7.53] for participants ≤50 years, and 1.90 (1.36 to 2.66) for participants >50 years, P for interaction 0.0846). Childhood SEP was not associated with CVD risk in women or men. Conclusions Adult SEP is an important predictor of CVD events in African American women and in younger African Americans. Childhood SEP was not associated with CVD events in this population. PMID:26019130

Prognostic value of somatosensory-evoked potentials in the surgical management of cervical spondylotic myelopathy.

PubMed

Hu, Yong; Ding, Yu; Ruan, Dike; Wong, Y W; Cheung, Kenneth M C; Luk, Keith D K

2008-05-01

Preoperative somatosensory-evoked potentials (SEPs) were retrospectively analyzed and classified, and compared with surgical outcome. To evaluate the value of the preoperative SEP waveform in predicting the clinical outcome after surgical management of cervical spondylotic myelopathy (CSM). SEPs have played an important role in spinal surgery. However, the value of SEPs in predicting the outcome of surgery for CSM remains controversial. This study enrolled 76 CSM patients who underwent surgical intervention. Median nerve SEPs were recorded before surgery. The Japanese Orthopedic Association (JOA) scoring system was used to evaluate the neurologic function before surgery and at postoperative follow-up at 1, 3, 6, 12, and 24 months. Patients were divided into 5 groups according to the classification of their preoperative SEP waveforms. Group I patients had normal SEPs, group IIa had normal latency and abnormal amplitude, group IIb had abnormal latency and normal amplitude, group III had abnormal latency and amplitude, and group IV had immeasurable waveforms. The myelopathic disability scores and surgical outcomes in different groups were compared by the Kruskal-Wallis test. The SEP classification was found to be significantly associated with the JOA score (Pearson's chi test, chi = 53.9, P < 0.05). There were no significant differences in JOA score recovery at different follow-up times within any SEP group. At 24 months after surgery, there was no significant difference in the recovery ratio between groups I and IIa, or between groups IIb and III (Kruskal-Wallis test, P > 0.05). However, the recovery ratio was significantly higher in groups I and IIa than in all the other groups (Kruskal-Wallis test, P < 0.05), and in groups IIb and III than in group IV (Kruskal-Wallis test, P < 0.05). SEP classification correlates well with CSM disability and postoperative recovery ratio. Median nerve SEP recordings would be a valuable and practical tool for the diagnosis and prognosis of myelopathy.

Effects of a Training Program Involving Body Cooling on Physical and Cognitive Capacities and Quality of Life in Multiple Sclerosis Patients: A Pilot Study.

PubMed

Gonzales, Benoit; Chopard, Gilles; Charry, Benjamin; Berger, Eric; Tripard, Julien; Magnin, Eloi; Groslambert, Alain

2017-01-01

Two methods using exercise and body cooling could influence the well-being of patients with multiple sclerosis (PwMS). The aim of this study was to determine whether wearing a cooling vest during a physical training program could increase the cognitive and physical capacities and quality of life in PwMS. Eighteen PwMS (49.6 ± 8 years; Expanded Disability Status Score 5.0 ± 1.0) were randomly assigned to a cooling or control group. PwMS underwent a 7-week physical training program. In the cooling group, PwMS wore a cooling vest during each training session, whereas in the control group, PwMS wore a cotton T-shirt. Before and after the training program, both groups completed the Isaacs Set Test (IST), Trail Making Test A-B (TMT A-B), SEP-59, Multidimensional Fatigue Inventory and performed a 6-minute walk test (6MWT). The cooling group showed significantly (p < 0.05) improved performance for IST, TMT A and 6MWT. Their emotional well-being and cognitive functions investigated in SEP-59 were significantly (p < 0.05) improved, and general and physical fatigue significantly (p < 0.05) decreased. This physical training program combined with a cooling strategy could have a significant positive influence on both cognitive and physical performances, perceived fatigue and emotional well-being in heat-sensitive PwMS. © 2017 S. Karger AG, Basel.

Subjective measures of socio-economic position and the wealth index: a comparative analysis.

PubMed

Howe, Laura D; Hargreaves, James R; Ploubidis, George B; De Stavola, Bianca L; Huttly, Sharon R A

2011-05-01

The wealth index is a commonly-used measure of socio-economic position (SEP) in low- and middle-income settings, but there is concern that it is strongly influenced by community-level as well as household-level factors. Subjective SEP indicators are infrequently used in health research. We use data from 11 280 households included in the Malawi Integrated Household Survey 2004/5. We compare the wealth index with four subjective measures of SEP: perceived food consumption adequacy, perceived overall consumption adequacy, an economic ladder question, and perceived income sufficiency. The wealth index is compared with each subjective SEP measure in terms of: (i) agreement of classification of households, (ii) targeting accuracy with respect to US$1-a-day poverty based on consumption expenditure, and (iii) the socio-economic processes (household- and community-level) giving rise to the SEP scores. Each subjective SEP indicator resulted in considerable differential classification of households compared with the wealth index. Three measures of subjective SEP (perceived food consumption adequacy, economic ladder question, and perceived income sufficiency) identified a higher proportion of dollar-a-day poor households as poor than the wealth index. The wealth index was strongly influenced by community infrastructure, but all subjective SEP indicators were free from strong community-level influence. The strengths and limitations of any measure of SEP depend on the context and purpose for which it is being used. In these data, the wealth index was strongly influenced by community infrastructure, whereas the subjective SEP measures were not, perhaps allowing analyses using them to disentangle household and community influences. Several subjective measures also corresponded to dollar-a-day poverty more strongly than the wealth index. Subjective measures may therefore be preferable to the wealth index in some circumstances, although they have their own set of potential biases.

Suprathermal and Solar Energetic Particles - Key questions for the Interstellar Mapping and Acceleration Probe (IMAP)

NASA Astrophysics Data System (ADS)

Desai, M. I.; McComas, D. J.; Christian, E. R.; Mewaldt, R. A.; Schwadron, N.

2014-12-01

Solar energetic particles or SEPs from suprathermal (few keV) up to relativistic (~few GeV) speeds are accelerated near the Sun in at least two ways, namely, (1) by magnetic reconnection-driven processes during solar flares resulting in impulsive SEPs and (2) at fast coronal-mass-ejection-driven shock waves that produce large gradual SEP events. Large gradual SEP events are of particular interest because the accompanying high-energy (>10s MeV) protons pose serious radiation threats to human explorers living and working outside low-Earth orbit and to technological assets such as communications and scientific satellites in space. However, a complete understanding of SEP events has eluded us primarily because their properties, as observed near Earth orbit, are smeared due to mixing and contributions from many important physical effects. Thus, despite being studied for decades, several key questions regarding SEP events remain unanswered. These include (1) What are the contributions of co-temporal flares, jets, and CME shocks to impulsive and gradual SEP events?; (2) Do flares contribute to large SEP events directly by providing high-energy particles and/or by providing the suprathermal seed population?; (3) What are the roles of ambient turbulence/waves and self-generated waves?; (4) What are the origins of the source populations and how do their temporal and spatial variations affect SEP properties?; and (5) How do diffusion and scattering during acceleration and propagation through the interplanetary medium affect SEP properties observed out in the heliosphere? This talk describes how during the next decade, inner heliospheric measurements from the Solar Probe Plus and Solar Orbiter in conjunction with high sensitivity measurements from the Interstellar Mapping and Acceleration Probe will provide the ground-truth for various models of particle acceleration and transport and address these questions.

Identification and Characterization of the Novel LysM Domain-Containing Surface Protein Sep from Lactobacillus fermentum BR11 and Its Use as a Peptide Fusion Partner in Lactobacillus and Lactococcus

PubMed Central

Turner, Mark S.; Hafner, Louise M.; Walsh, Terry; Giffard, Philip M.

2004-01-01

Examination of supernatant fractions from broth cultures of Lactobacillus fermentum BR11 revealed the presence of a number of proteins, including a 27-kDa protein termed Sep. The amino-terminal sequence of Sep was determined, and the gene encoding it was cloned and sequenced. Sep is a 205-amino-acid protein and contains a 30-amino-acid secretion signal and has overall homology (between 39 and 92% identity) with similarly sized proteins of Lactobacillus reuteri, Enterococcus faecium, Streptococcus pneumoniae, Streptococcus agalactiae, and Lactobacillus plantarum. The carboxy-terminal 81 amino acids of Sep also have strong homology (86% identity) to the carboxy termini of the aggregation-promoting factor (APF) surface proteins of Lactobacillus gasseri and Lactobacillus johnsonii. The mature amino terminus of Sep contains a putative peptidoglycan-binding LysM domain, thereby making it distinct from APF proteins. We have identified a common motif within LysM domains that is shared with carbohydrate binding YG motifs which are found in streptococcal glucan-binding proteins and glucosyltransferases. Sep was investigated as a heterologous peptide expression vector in L. fermentum, Lactobacillus rhamnosus GG and Lactococcus lactis MG1363. Modified Sep containing an amino-terminal six-histidine epitope was found associated with the cells but was largely present in the supernatant in the L. fermentum, L. rhamnosus, and L. lactis hosts. Sep as well as the previously described surface protein BspA were used to express and secrete in L. fermentum or L. rhamnosus a fragment of human E-cadherin, which contains the receptor region for Listeria monocytogenes. This study demonstrates that Sep has potential for heterologous protein expression and export in lactic acid bacteria. PMID:15184172

Interactive effect of acute pain and motor learning acquisition on sensorimotor integration and motor learning outcomes

PubMed Central

Dancey, Erin; Andrew, Danielle; Yielder, Paul

2016-01-01

Previous work has demonstrated differential changes in early somatosensory evoked potentials (SEPs) when motor learning acquisition occurred in the presence of acute pain; however, the learning task was insufficiently complex to determine how these underlying neurophysiological differences impacted learning acquisition and retention. To address this limitation, we have utilized a complex motor task in conjunction with SEPs. Two groups of 12 participants (n = 24) were randomly assigned to either a capsaicin (capsaicin cream) or a control (inert lotion) group. SEP amplitudes were collected at baseline, after application, and after motor learning acquisition. Participants performed a motor acquisition task followed by a pain-free retention task within 24–48 h. After motor learning acquisition, the amplitude of the N20 SEP peak significantly increased (P < 0.05) and the N24 SEP peak significantly decreased (P < 0.001) for the control group while the N18 SEP peak significantly decreased (P < 0.01) for the capsaicin group. The N30 SEP peak was significantly increased (P < 0.001) after motor learning acquisition for both groups. The P25 SEP peak decreased significantly (P < 0.05) after the application of capsaicin cream. Both groups improved in accuracy after motor learning acquisition (P < 0.001). The capsaicin group outperformed the control group before motor learning acquisition (P < 0.05) and after motor learning acquisition (P < 0.05) and approached significance at retention (P = 0.06). Improved motor learning in the presence of capsaicin provides support for the enhancement of motor learning while in acute pain. In addition, the changes in SEP peak amplitudes suggest that early SEP changes reflect neurophysiological alterations accompanying both motor learning and mild acute pain. PMID:27535371

Kidney Disease in Women is Associated with Disadvantaged Childhood Socioeconomic Position.

PubMed

Canney, Mark; Leahy, Siobhan; Scarlett, Siobhan; Kenny, Rose Anne; Little, Mark A; O'Seaghdha, Conall M; McCrory, Cathal

2018-01-01

Socioeconomic position (SEP) is an important determinant of health and it is dynamic across the entire lifespan. We sought to investigate the relationship between life-course SEP and chronic kidney disease (CKD) using 3 conceptual models: critical period, pathway and accumulation. Cross-sectional analysis of 4,996 participants from The Irish Longitudinal Study on Ageing, a nationally representative cohort of community-dwelling adults aged ≥50 years. We defined childhood and adulthood SEP according to father's and respondent's occupation respectively. SEP was categorised as high (reference), intermediate, low and never worked. CKD was defined as a glomerular filtration rate < 60 mL/min/1.73 m2 estimated from the combination of creatinine and cystatin C. We used logistic regression to estimate the age-adjusted association between SEP and CKD separately in men and women. Low childhood SEP was strongly associated with CKD in women, after adjusting for adulthood SEP (OR 1.90 [95% CI 1.24-2.92]), supporting the critical period hypothesis. This association was not explained by traditional CKD risk factors. Women who experienced low childhood SEP and whose circumstances improved in adulthood also had increased odds of CKD, further supporting a critical period effect in childhood. There was comparatively less evidence in support of the pathway or accumulation models. We did not observe a statistically significant association between SEP and CKD in men. Our findings suggest that women exposed to disadvantaged SEP in childhood represent an at-risk group in whom there may be opportunities for identification of CKD and facilitation of health-promoting behaviours from an early age. © 2018 S. Karger AG, Basel.

Deficiency of selenoprotein S, an endoplasmic reticulum resident oxidoreductase, impairs the contractile function of fast twitch hindlimb muscles.

PubMed

Addinsall, Alex Bernard; Wright, Craig Robert; Shaw, Christopher S; McRae, Natasha L; Forgan, Leonard George; Weng, Chia-Heng; Conlan, Xavier A; Francis, Paul S; Smith, Zoe M; Andrikopoulos, Sofianos; Stupka, Nicole

2018-04-18

Selenoprotein S (Seps1) is an endoplasmic reticulum (ER) resident antioxidant implicated in ER stress and inflammation. In human vastus lateralis and mouse hindlimb muscles, Seps1 localization and expression was fiber type specific. In male Seps1 +/- heterozygous mice, spontaneous physical activity was reduced compared to wild type littermates ( d=1.10, P=0.029). A similar trend also observed in Seps1 -/- knockout mice ( d=1.12, P=0.051). Whole body metabolism, body composition, extensor digitorum longus (EDL) and soleus mass, and myofibre diameter were unaffected by genotype. However, in isolated fast EDL muscles from Seps1 -/- knockout mice, the force frequency curve (1-120 Hz; FFC) was shifted downward versus EDL muscles from wild type littermates ( d=0.55, P=0.002), suggestive of reduced strength. During 4 min of intermittent, submaximal (60 Hz) stimulation, the genetic deletion or reduction of Seps1 decreased EDL force production ( d=0.52, P<0.001). Furthermore, at the start of the intermittent stimulation protocol, when compared to the 60 Hz stimulation of the FFC, EDL muscles from Seps1 -/- knockout or Seps1 +/- heterozygous mice produced 10% less force than those from wild type littermates ( d=0.31, P<0.001 and d=0.39, P=0.015). This functional impairment was associated with reduced mRNA transcript abundance of thioredoxin-1 ( Trx1), thioredoxin interacting protein ( Txnip), and the ER stress markers Chop and Grp94. Whereas, in slow soleus muscles, Seps1 deletion did not compromise contractile function and Trx1 ( d=1.38, P=0.012) and Txnip ( d=1.27, P=0.025) gene expression was increased. Seps1 is a novel regulator of contractile function and cellular stress responses in fast twitch muscles.

Prediction and warning system of SEP events and solar flares for risk estimation in space launch operations

NASA Astrophysics Data System (ADS)

García-Rigo, Alberto; Núñez, Marlon; Qahwaji, Rami; Ashamari, Omar; Jiggens, Piers; Pérez, Gustau; Hernández-Pajares, Manuel; Hilgers, Alain

2016-07-01

A web-based prototype system for predicting solar energetic particle (SEP) events and solar flares for use by space launch operators is presented. The system has been developed as a result of the European Space Agency (ESA) project SEPsFLAREs (Solar Events Prediction system For space LAunch Risk Estimation). The system consists of several modules covering the prediction of solar flares and early SEP Warnings (labeled Warning tool), the prediction of SEP event occurrence and onset, and the prediction of SEP event peak and duration. In addition, the system acquires data for solar flare nowcasting from Global Navigation Satellite Systems (GNSS)-based techniques (GNSS Solar Flare Detector, GSFLAD and the Sunlit Ionosphere Sudden Total Electron Content Enhancement Detector, SISTED) as additional independent products that may also prove useful for space launch operators.

Objective and Subjective Socioeconomic Gradients Exist for Sleep Quality, Sleep Latency, Sleep Duration, Weekend Oversleep, and Daytime Sleepiness in Adults

PubMed Central

Jarrin, Denise Christina; McGrath, Jennifer J.; Silverstein, Janice E.; Drake, Christopher

2017-01-01

Socioeconomic gradients exist for multiple health outcomes. Lower objective socioeconomic position (SEP), whether measured by income, education, or occupation, is associated with inadequate sleep. Less is known about whether one’s perceived ranking of their social status, or subjective SEP, affects sleep. This study examined whether a subjective socioeconomic gradient exists for sleep while controlling for objective SEP. Participants (N = 177; age, M = 45.3 years, SD = 6.3 years) completed the Pittsburgh Sleep Quality Index, Epworth Sleepiness Scale, MacArthur Ladder, and other self-report measures to assess sleep and objective SEP. Subjective SEP trumped objective SEP as a better predictor of sleep duration, daytime sleepiness, and weekend oversleep. These findings highlight the need to expand our framework to better understand the mechanisms underlying socioeconomic gradients and sleep. PMID:23136841

Deflections of Fast Coronal Mass Ejections and the Properties of Associated Solar Energetic Particle Events

NASA Technical Reports Server (NTRS)

Kahler, S. W.; Akiyama, S.; Gopalswamy, N.

2012-01-01

The onset times and peak intensities of solar energetic particle (SEP) events at Earth have long been thought to be influenced by the open magnetic fields of coronal holes (CHs). The original idea was that a CH lying between the solar SEP source region and the magnetic footpoint of the 1 AU observer would result in a delay in onset and/or a decrease in the peak intensity of that SEP event. Recently, Gopalswamy et al. showed that CHs near coronal mass ejection (CME) source regions can deflect fast CMEs from their expected trajectories in space, explaining the appearance of driverless shocks at 1 AU from CMEs ejected near solar central meridian (CM). This suggests that SEP events originating in CME-driven shocks may show variations attributable to CH deflections of the CME trajectories. Here, we use a CH magnetic force parameter to examine possible effects of CHs on the timing and intensities of 41 observed gradual E approx 20 MeV SEP events with CME source regions within 20 deg. of CM. We find no systematic CH effects on SEP event intensity profiles. Furthermore, we find no correlation between the CME leading-edge measured position angles and SEP event properties, suggesting that the widths of CME-driven shock sources of the SEPs are much larger than the CMEs. Independently of the SEP event properties, we do find evidence for significant CME deflections by CH fields in these events

Magnitude of income-related disparities in adverse perinatal outcomes.

PubMed

Shankardass, Ketan; O'Campo, Patricia; Dodds, Linda; Fahey, John; Joseph, Ks; Morinis, Julia; Allen, Victoria M

2014-03-04

To assess and compare multiple measurements of socioeconomic position (SEP) in order to determine the relationship with adverse perinatal outcomes across various contexts. A birth registry, the Nova Scotia Atlee Perinatal Database, was confidentially linked to income tax and related information for the year in which delivery occurred. Multiple logistic regression was used to examine odds ratios between multiple indicators of SEP and multiple adverse perinatal outcomes in 117734 singleton births between 1988 and 2003. Models for after tax family income were also adjusted for neighborhood deprivation to gauge the relative magnitude of effects related to SEP at both levels. Effects of SEP were stratified by single- versus multiple-parent family composition, and by urban versus rural location of residence. The risk of small for gestational age and spontaneous preterm birth was higher across all the indicators of lower SEP, while risk for large for gestational age was lower across indicators of lower SEP. Higher risk of postneonatal death was demonstrated for several measures of lower SEP. Higher material deprivation in the neighborhood of residence was associated with increased risk for perinatal death, small for gestational age birth, and iatrogenic and spontaneous preterm birth. Family composition and urbanicity were shown to modify the association between income and some perinatal outcomes. This study highlights the importance of understanding the definitions of SEP and the mechanisms that lead to the association between income and poor perinatal outcomes, and broadening the types of SEP measures used in some cases.

Magnitude of income-related disparities in adverse perinatal outcomes

PubMed Central

2014-01-01

Background To assess and compare multiple measurements of socioeconomic position (SEP) in order to determine the relationship with adverse perinatal outcomes across various contexts. Methods A birth registry, the Nova Scotia Atlee Perinatal Database, was confidentially linked to income tax and related information for the year in which delivery occurred. Multiple logistic regression was used to examine odds ratios between multiple indicators of SEP and multiple adverse perinatal outcomes in 117734 singleton births between 1988 and 2003. Models for after tax family income were also adjusted for neighborhood deprivation to gauge the relative magnitude of effects related to SEP at both levels. Effects of SEP were stratified by single- versus multiple-parent family composition, and by urban versus rural location of residence. Results The risk of small for gestational age and spontaneous preterm birth was higher across all the indicators of lower SEP, while risk for large for gestational age was lower across indicators of lower SEP. Higher risk of postneonatal death was demonstrated for several measures of lower SEP. Higher material deprivation in the neighborhood of residence was associated with increased risk for perinatal death, small for gestational age birth, and iatrogenic and spontaneous preterm birth. Family composition and urbanicity were shown to modify the association between income and some perinatal outcomes. Conclusions This study highlights the importance of understanding the definitions of SEP and the mechanisms that lead to the association between income and poor perinatal outcomes, and broadening the types of SEP measures used in some cases. PMID:24589212

Absolute rather than relative income is a better socioeconomic predictor of chronic obstructive pulmonary disease in Swedish adults.

PubMed

Axelsson Fisk, Sten; Merlo, Juan

2017-05-04

While psychosocial theory claims that socioeconomic status (SES), acting through social comparisons, has an important influence on susceptibility to disease, materialistic theory says that socioeconomic position (SEP) and related access to material resources matter more. However, the relative role of SEP versus SES in chronic obstructive pulmonary disease (COPD) risk has still not been examined. We investigated the association between SES/SEP and COPD risk among 667 094 older adults, aged 55 to 60, residing in Sweden between 2006 and 2011. Absolute income in five groups by population quintiles depicted SEP and relative income expressed as quintile groups within each absolute income group represented SES. We performed sex-stratified logistic regression models to estimate odds ratios and the area under the receiver operator curve (AUC) to compare the discriminatory accuracy of SES and SEP in relation to COPD. Even though both absolute (SEP) and relative income (SES) were associated with COPD risk, only absolute income (SEP) presented a clear gradient, so the poorest had a three-fold higher COPD risk than the richest individuals. While the AUC for a model including only age was 0.54 and 0.55 when including relative income (SES), it increased to 0.65 when accounting for absolute income (SEP). SEP rather than SES demonstrated a consistent association with COPD. Our study supports the materialistic theory. Access to material resources seems more relevant to COPD risk than the consequences of low relative income.

JPRS Report, Soviet Union, Political Affairs.

DTIC Science & Technology

1990-12-04

PRAVITELSTVENNYY VESTNIKNo 38, Sep 90] 49 Deputy Minister Assesses Pollution Impact on Public Health [A. Kondrusev; PRAVDA, 14 Nov 90] 50 Vorontsov Calls...Salykov on Aral Sea Situation [K. Salykov; SOVETSKAYA KULTURA No 37, 15 Sep 90] 69 Turkmen Government Examines Aral Sea Impact on Tashauz Oblast...PRAVDA UKRAINY, 28 Sep 90] 75 Current Chernobyl Impact on Kiev Urban Area Detailed at Roundtable fV.G. Baryakhtar; PRAVDA UKRAINY, 23 Sep 90] 77

Socio-economic position as an intervention against overweight and obesity in children: a systematic review and meta-analysis

NASA Astrophysics Data System (ADS)

Wu, Shunquan; Ding, Yingying; Wu, Fuquan; Li, Ruisheng; Hu, Yan; Hou, Jun; Mao, Panyong

2015-06-01

Studies that investigated the association between socio-economic position (SEP) and obesity in children suggest inconsistent results. The aim of this study is to summarize and quantify the current evidence on SEP and risks of overweight and obesity in children aged 0-15 years. Relevant studies published between 1990 to Sep 4, 2014 were searched in Medline, Web of Science, Embase, and the Cochrane Database of Systematic Reviews. Risk estimates from individual studies were pooled using random-effects models, according to lowest vs the highest SEP category. A total of 62 articles were included in the meta-analysis. The odds of both overweight risk and obesity risk were higher in the children with lowest SEP than in those with highest SEP (OR, 1.10, 95% CI: 1.03-1.17, and OR, 1.41, 95% CI: 1.29-1.55, respectively). Sub-group analyses showed that the inverse relationships between SEP and childhood overweight and obesity were only found in high-income countries and in more economic developed areas. In conclusion, our study suggests that children with lower SEP had higher risks of overweight and obesity, and the increased risks were independent of the income levels of countries.

Effects of socioeconomic position and social mobility on linear growth from early childhood until adolescence.

PubMed

Muraro, Ana Paula; Souza, Rita Adriana Gomes de; Rodrigues, Paulo Rogério Melo; Ferreira, Márcia Gonçalves; Sichieri, Rosely

2017-01-01

To assess the effect of socioeconomic position (SEP) in childhood and social mobility on linear growth through adolescence in a population-based cohort. Children born in Cuiabá-MT, central-western Brazil, were evaluated during 1994 - 1999. They were first assessed during 1999 - 2000 (0 - 5 years) and again during 2009 - 2011 (10 - 17 years), and their height-for-age was evaluated during these two periods.Awealth index was used to classify the SEP of each child's family as low, medium, or high. Social mobility was categorized as upward mobility or no upward mobility. Linear mixed models were used. We evaluated 1,716 children (71.4% of baseline) after 10 years, and 60.6% of the families showed upward mobility, with a higher percentage among the lowest economic classes. A higher height-for-age was also observed among those from families with a high SEP both in childhood (low SEP= -0.35 z-score; high SEP= 0.15 z-score, p < 0.01) and adolescence (low SEP= -0.01 z-score; high SEP= 0.45 z-score, p < 0.01), whereas upward mobility did not affect their linear growth. Expressive social mobility was observed, but SEP in childhood and social mobility did not greatly influence linear growth through childhood in this central-western Brazilian cohort.

Investigating the Impact of Current Sheet Crossings on the Propagation of Solar Energetic Particles in the Inner Heliosphere

NASA Astrophysics Data System (ADS)

Schooley, A. K.; Kahler, S.; Lepri, S. T.; Liemohn, M. W.

2017-12-01

Gradual solar energetic particle events (SEPs) are produced in the solar corona and as these particle events propagate through the inner heliosphere and interplanetary space they might encounter intervening magnetic obstacles such as the heliospheric current sheet. These encounters may impact SEP acceleration or production. We investigate the extent to which propagation through these intervening structures might be affecting later in-situ SEP measurements at 1 AU. By analyzing large gradual SEP rise phases in a multi-year survey, we investigate the impact crossing a current sheet or other interplanetary magnetic structure has on in-situ SEP time-intensity profiles. Simultaneous Advanced Composition Explorer (ACE) magnetometer observations and measurements of suprathermal electron pitch angle distributions from ACE's Solar Wind Electron, Proton & Alpha Monitor (SWEPAM) are considered to indicate changes in magnetic polarity and magnetic topology. Potential field source surface models of the heliospheric current sheet are used to validate potential current sheet crossing times. We discuss those magnetic obstacles identified that SEPs likely encountered. We discuss the frequency of such encounters, their possible structure and their impact on the SEP time-intensity profiles. Preliminary results indicate that possible intervening interplanetary magnetic structures should be considered when analyzing in-situ SEP observations.

Component analysis of somatosensory evoked potentials for identifying spinal cord injury location.

PubMed

Wang, Yazhou; Li, Guangsheng; Luk, Keith D K; Hu, Yong

2017-05-24

This study aims to determine whether the time-frequency components (TFCs) of somatosensory evoked potentials (SEPs) can be used to identify the specific location of a compressive spinal cord injury using a classification technique. Waveforms of SEPs after compressive injuries at various locations (C4, C5 and C6) in rat spinal cords were decomposed into a series of TFCs using a high-resolution time-frequency analysis method. A classification method based on support vector machine (SVM) was applied to the distributions of these TFCs among different pathological locations. The difference among injury locations manifests itself in different categories of SEP TFCs. High-energy TFCs of normal-state SEPs have significantly higher power and frequency than those of injury-state SEPs. The location of C5 is characterized by a unique distribution pattern of middle-energy TFCs. The difference between C4 and C6 is evidenced by the distribution pattern of low-energy TFCs. The proposed classification method based on SEP TFCs offers a discrimination accuracy of 80.2%. In this study, meaningful information contained in various SEP components was investigated and used to propose a new application of SEPs for identification of the location of pathological changes in the cervical spinal cord.

Socio-economic position as an intervention against overweight and obesity in children: a systematic review and meta-analysis

PubMed Central

Wu, Shunquan; Ding, Yingying; Wu, Fuquan; Li, Ruisheng; Hu, Yan; Hou, Jun; Mao, Panyong

2015-01-01

Studies that investigated the association between socio-economic position (SEP) and obesity in children suggest inconsistent results. The aim of this study is to summarize and quantify the current evidence on SEP and risks of overweight and obesity in children aged 0–15 years. Relevant studies published between 1990 to Sep 4, 2014 were searched in Medline, Web of Science, Embase, and the Cochrane Database of Systematic Reviews. Risk estimates from individual studies were pooled using random-effects models, according to lowest vs the highest SEP category. A total of 62 articles were included in the meta-analysis. The odds of both overweight risk and obesity risk were higher in the children with lowest SEP than in those with highest SEP (OR, 1.10, 95% CI: 1.03–1.17, and OR, 1.41, 95% CI: 1.29–1.55, respectively). Sub-group analyses showed that the inverse relationships between SEP and childhood overweight and obesity were only found in high-income countries and in more economic developed areas. In conclusion, our study suggests that children with lower SEP had higher risks of overweight and obesity, and the increased risks were independent of the income levels of countries. PMID:26112253

DOES A SCALING LAW EXIST BETWEEN SOLAR ENERGETIC PARTICLE EVENTS AND SOLAR FLARES?

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kahler, S. W., E-mail: AFRL.RVB.PA@kirtland.af.mil

2013-05-20

Among many other natural processes, the size distributions of solar X-ray flares and solar energetic particle (SEP) events are scale-invariant power laws. The measured distributions of SEP events prove to be distinctly flatter, i.e., have smaller power-law slopes, than those of the flares. This has led to speculation that the two distributions are related through a scaling law, first suggested by Hudson, which implies a direct nonlinear physical connection between the processes producing the flares and those producing the SEP events. We present four arguments against this interpretation. First, a true scaling must relate SEP events to all flare X-raymore » events, and not to a small subset of the X-ray event population. We also show that the assumed scaling law is not mathematically valid and that although the flare X-ray and SEP event data are correlated, they are highly scattered and not necessarily related through an assumed scaling of the two phenomena. An interpretation of SEP events within the context of a recent model of fractal-diffusive self-organized criticality by Aschwanden provides a physical basis for why the SEP distributions should be flatter than those of solar flares. These arguments provide evidence against a close physical connection of flares with SEP production.« less

Recent Progress on Understanding SEP Acceleration and Transport

NASA Astrophysics Data System (ADS)

Cohen, C.

2017-12-01

Joint observations between near-Earth spacecraft and the twin STEREO spacecraft have allowed new examinations of the longitudinal extent of solar energetic particles (SEPs). Although the radial dependence will not be measured in detail until Parker Solar Probe and Solar Orbiter have launched, recent developments in modeling SEP acceleration and transport have revealed interesting dependences on magnetic field configurations and the characteristics of seed particle populations. This talk will review recent SEP in-situ observations along with theoretical studies and their implications for our understanding of SEP acceleration and transport in the inner heliosphere and our expectations for upcoming Solar Orbiter and Parker Solar Probe observations.

Solar abundances as derived from solar energetic particles

NASA Technical Reports Server (NTRS)

Stone, E. C.

1989-01-01

Recent studies have shown that there are well defined average abundances of heavy (Z above 2) solar energetic particles (SEPs), with variations in the acceleration and propagation producing a systematic flare-to-flare fractionation that depends on the charge per unit mass of the ion. Correcting the average SEP abundances for this fractionation yields SEP-derived coronal abundances for 20 elements. High-resolution SEP studies have also provided isotopic abundances for five elements. SEP-derived abundances indicate that elements with high first ionization potentials (greater than 10 eV) are depleted in the corona relative to the photosphere and provide new information on the solar abundance of C and Ne-22.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Harner, E.J.; Gilfillan, E.S.

Two large shoreline assessment studies conducted in 1990 in Prince William Sound, Alaska, after the Exxon Valdez oil spill used different design strategies to determine the impact of oiling on shoreline biota. One of the studies, the Coastal Habitat Injury Assessment (CHIA) conducted for the Exxon Valdez Oil Spill Council, used matched pairs of sites, normal population distributions for biota, and meta-analysis. The power of the CHIA study to detect oiling impacts depends on being able to identify and select appropriate pairs of sites for comparison. The CHIA study also increased the oiling signal by focusing on moderate to heavilymore » oiled sites. The Shoreline Ecology Program (SEP), conducted for Exxon, used a stratified-random-sampling study design, normal and non-normal population distributions and covariates. The SEP study was able to detect oiling impacts by using a sufficient number of sites and widely spaced transects.« less

A simple and rapid in situ preconcentration method for the determination of phosphate in environmental waters by use of solid-phase extraction, and its applications to brackish lake waters.

PubMed

Okumura, M; Tong, L; Fujinaga, K; Seike, Y

2001-05-01

A simple and rapid in situ preconcentration method for the determination of phosphate in environmental waters has been developed for field analysis. This method is based on solid-phase extraction on a zirconium-loaded Sep-Pack Accell CM cartridge (Zr-SP) and is applicable to studies in which sampling is performed by use of a graduated syringe to prevent contamination and to ensure easy operation at sampling sites. The Zr-SP cartridge was prepared by passing 0.1 mol L(-1) zirconium solution through a Sep-Pak Accell CM cartridge, packed with cation exchange sorbent based on a silica matrix. The adsorption of phosphate and its desorption depend only on the pH of the solution. A water sample containing phosphate was adjusted to pH 2 and passed through the Zr-SP cartridge to collect it. The retained phosphate was quantitatively eluted with 0.5 mol L(-1) sodium hydroxide solution. The phosphate retained in the Zr-SP cartridge was stable for at least one month. The established preconcentration method was successfully applied to brackish lake waters to investigate seasonal changes in the distribution and behavior of phosphate in a brackish lake.

Widely distributed SEP events and pseudostreamers

NASA Astrophysics Data System (ADS)

Panasenco, O.; Panasenco, A.; Velli, M.

2017-12-01

Our analysis of the pseudostreamer magnetic topology reveals new interesting implications for understanding SEP acceleration in CMEs. The possible reasons for the wide distribution of some SEP events can be the presence of pseudostreamers in the vicinity of the SEP source region which creates conditions for the existence of strong longitudinal spread of energetic particles as well as an anomalous longitudinal solar wind magnetic field component. We reconstructed the 3D magnetic configurations of pseudostreamers with a potential field source surface (PFSS) model, which uses as a lower boundary condition the magnetic field derived from an evolving surface-flux transport model. In order to estimate the possible magnetic connections between the spacecraft and the SEP source region, we used the Parker spiral, ENLIL and PFSS models. We found that in cases of the wide SEP distributions a specific configuration of magnetic field appears to exist at low solar latitudes all the way around the sun, we named this phenomenon a pseudostreamers belt. It appears that the presence of the well developed pseudostreamer or, rather multiple pseudostreamers, organized into the pseudostreamer belt can be considered as a very favorable condition for wide SEP events.

Plasma Oscillation Characterization of NASA's HERMeS Hall Thruster via High Speed Imaging

NASA Technical Reports Server (NTRS)

Huang, Wensheng; Kamhawi, Hani; Haag, Thomas W.

2016-01-01

For missions beyond low Earth orbit, spacecraft size and mass can be dominated by onboard chemical propulsion systems and propellants that may constitute more than 50 percent of the spacecraft mass. This impact can be substantially reduced through the utilization of Solar Electric Propulsion (SEP) due to its substantially higher specific impulse. Studies performed for NASA's Human Exploration and Operations Mission Directorate and Science Mission Directorate have demonstrated that a 50kW-class SEP capability can be enabling for both near term and future architectures and science missions. A high-power SEP element is integral to the Evolvable Mars Campaign, which presents an approach to establish an affordable evolutionary human exploration architecture. To enable SEP missions at the power levels required for these applications, an in-space demonstration of an operational 50kW-class SEP spacecraft has been proposed as a SEP Technology Demonstration Mission (TDM). In 2010 NASA's Space Technology Mission Directorate (STMD) began developing high-power electric propulsion technologies. The maturation of these critical technologies has made mission concepts utilizing high-power SEP viable.

Test research of Surface Electromagnetic Prospecting (SEP) System in Yang-jia-zhang-zi of Liao Ning province

NASA Astrophysics Data System (ADS)

Di, Q.

2013-12-01

In recent years, deep prospecting method such as magnetotelluric and controlled source audio-frequency magnetotelluric develop rapidly, but the instruments almost monopolized by several big geophysical companies from the United States, Canada and Germany. From prospecting practice, foreign equipment adaptation on complicated geological conditions in China is unsatisfactory. As increasing of national strength, electromagnetic exploration system development independently is on the agenda. In the year of 2010, the institute of geology and geophysics, Chinese academy of sciences, took on one subject of the SinoProbe project, the research of surface Electromagnetic Prospecting (SEP) System, and has achieved some achievements. SEP is an independent research instrumentation system, which is available for MT, AMT and CSAMT soundings. After laboratory testing, in order to test SEP's performance in field, the yang-jia-zhang-zi molybdenum deposit area is selected for SEP experiment. All modules and components of SEP system have been tested, and the field ability of the whole system also has been tested. The experimental results show that SEP performance has reached the level of commercial instruments.

Patriot Advanced Capability-3 (PAC-3)

DTIC Science & Technology

2013-12-01

attack than is possible with actuator -driven aerodynamic control surfaces alone. The Patriot system is deployed world-wide in defense of U.S. and...Start Complete Low Rate Initial Production .. Low Rate Initial Production .. Low Rate Production First D ... First Unit EQuipped IOT &E Start...MAR 2002 SEP 2001 IOT &E Start JAN 2002 JAN 2002 JUL 2002 JAN 2002 Complete SEP 2002 SEP 2002 MAR 2003 SEP 2002 Block 2002 Production Decision OCT

EPA/ECLSS consumables analyses for the Spacelab 1 flight

NASA Technical Reports Server (NTRS)

Steines, G. J.; Pipher, M. D.

1976-01-01

The results of electrical power system (EPS) and environmental control/life support system (ECLSS) consumables analyses of the Spacelab 1 mission are presented. The analyses were performed to assess the capability of the orbiter systems to support the proposed mission and to establish the various non propulsive consumables requirements. The EPS analysis was performed using the shuttle electrical power system (SEPS) analysis computer program. The ECLSS analysis was performed using the shuttle environmental consumables requirements evaluation tool (SECRET) program.

The Automated Programming of Electronic Displays.

DTIC Science & Technology

1986-09-01

A182 931 THE AUTOMATED PROGRAMMING OF ELECTRONIC DISPLAYSCU) 11 SOFTWARE CONSULTING SPECIALIST INC FORT MAYNE IN R W HASKER ET AL SEP 86 AFURL-TR-86...M. R. Fritsch Software Consulting Specialists , Inc. ( P. 0. Box 15367 O Fort Wayne, IN 46885 00 V September 1986 S Final Report for Period July 1985...N 05 111 0 PRO~l S AGRAM CL(CWfT.P^OJ(CV. TASK Software Consulting Specialists , Inc. ;Ms CA 01 Wol WUNSCAS P. 0. Box 15367 62201F Fort Wayne, IN

Novel Method of Noninvasive Detection and Assessment of Gas Emboli and DCS

DTIC Science & Technology

2010-12-01

Young Investigator Program, Undersea Medicine Research Program (Code: 34; PO: CDR Matthew Swiergosz). Report Documentation Page Form...esponse at 665 tte with respe glass thicknes ces of glass cu 00 µm thick g to 1,2,3,4 i -D profile sho µm peak. ct to the beam s, B- optical vette...arterial CO2 embolism occuring after laparoscopic surgery: A case report," Undersea & Hyperbaric Medicine, vol. 33, pp. 317-320, Sep-Oct 2006. [29] T

Experiences of CNES and SEP on space mechanisms rotating at low speed

NASA Technical Reports Server (NTRS)

Atlas, G.; Thomin, G.

1987-01-01

Some aspects of knowledge acquired in the field of space mechanisms by Societe Europeenne de Propulsion and Centre National d'Etudes Spatiales in International and French National space programs are described. The experience described centers on the development of these programs: The MEGS (Mechanisme d'Etrainement du Generateur Solaire), and the MOGS (Mechanisme d'Orientation de Generateur Solaire), both solar array drive mechanisms. Key design areas and the mechanism performance obtained are highlighted. Some test problems with the MEGS sliprings are discussed.

Engineering support activities for the Apollo 17 Surface Electrical Properties Experiment.

NASA Technical Reports Server (NTRS)

Cubley, H. D.

1972-01-01

Description of the engineering support activities which were required to ensure fulfillment of objectives specified for the Apollo 17 SEP (Surface Electrical Properties) Experiment. Attention is given to procedural steps involving verification of hardware acceptability to the astronauts, computer simulation of the experiment hardware, field trials, receiver antenna pattern measurements, and the qualification test program.

77 FR 44618 - Disease, Disability, and Injury Prevention and Control Special Emphasis Panel (SEP): Initial Review

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-30

... Officer, National Institute for Occupational Safety and Health, CDC, 1095 Willowdale Road, Mailstop G800... announced below concerns the World Trade Center Health Program Outreach and Education Plan RFA-OH12-1201... Diagonal Road, Alexandria, Virginia 22314, Telephone: (703) 684-5900. Status: The meeting will be closed to...

76 FR 50757 - Notice of Lodging of a Consent Decree Under the Clean Water Act

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-16

... March 2023 by completing sewer separation projects and upgrades at an approximate cost of $4.2 million... and (3) establish and operate a yard waste pick-up and recycling program for Elkins' residents as a Supplemental Environmental Project (``SEP''). The Department of Justice will receive for a period of thirty (30...

In-Space Propulsion Technology Program Solar Electric Propulsion Technologies

NASA Technical Reports Server (NTRS)

Dankanich, John W.

2006-01-01

NASA's In-space Propulsion (ISP) Technology Project is developing new propulsion technologies that can enable or enhance near and mid-term NASA science missions. The Solar Electric Propulsion (SEP) technology area has been investing in NASA s Evolutionary Xenon Thruster (NEXT), the High Voltage Hall Accelerator (HiVHAC), lightweight reliable feed systems, wear testing, and thruster modeling. These investments are specifically targeted to increase planetary science payload capability, expand the envelope of planetary science destinations, and significantly reduce the travel times, risk, and cost of NASA planetary science missions. Status and expected capabilities of the SEP technologies are reviewed in this presentation. The SEP technology area supports numerous mission studies and architecture analyses to determine which investments will give the greatest benefit to science missions. Both the NEXT and HiVHAC thrusters have modified their nominal throttle tables to better utilize diminished solar array power on outbound missions. A new life extension mechanism has been implemented on HiVHAC to increase the throughput capability on low-power systems to meet the needs of cost-capped missions. Lower complexity, more reliable feed system components common to all electric propulsion (EP) systems are being developed. ISP has also leveraged commercial investments to further validate new ion and hall thruster technologies and to potentially lower EP mission costs.

Associations between race, lifecourse socioeconomic position and prevalence of diabetes among US women and men: results from a population-based panel study.

PubMed

Insaf, T Z; Strogatz, D S; Yucel, R M; Chasan-Taber, L; Shaw, B A

2014-04-01

Few studies have examined the degree to which racial disparities in the development of diabetes are accounted by differences in lifecourse socioeconomic position (SEP). We assessed the association between race, lifecourse SEP measures and prevalence of diabetes in a representative US sample of black and white adults. A generalised estimating equations approach was used with a sample of 3497 adults from the Americans' Changing Lives study. Sex-specific models were calculated to compute prevalence ratios (PR) for associations of race and SEP with self-reported diagnoses of diabetes. For men, childhood and adult SEP were unrelated to diabetes, and adjustment for lifecourse SEP had little effect on the excess diabetes in blacks (PR=1.56, 95% CI 1.11 to 2.21). Adjustment for measures of lifecourse SEP reduced the PR for the association between race and diabetes in women from 1.96 (95% CI 1.52 to 2.54) to 1.40 (95% CI 1.04 to 1.87) with the respondent's education responsible for most of the reduction in the association. However, diabetes was also inversely associated with father's education, and low SEP throughout the lifecourse was associated with a nearly threefold increase in diabetes (PR=2.89, 95% CI 2.10 to 3.99). Racial disparities in diabetes existed among both men and women, but lifecourse SEP was related to diabetes only among women. The pathway and cumulative hypotheses for lifecourse SEP effects on diabetes may be especially salient for women.

A Sub-Element in PRE enhances nuclear export of intronless mRNAs by recruiting the TREX complex via ZC3H18

PubMed Central

Chi, Binkai; Wang, Ke; Du, Yanhua; Gui, Bin; Chang, Xingya; Wang, Lantian; Fan, Jing; Chen, She; Wu, Xudong; Li, Guohui; Cheng, Hong

2014-01-01

Viral RNA elements that facilitate mRNA export are useful tools for identifying cellular RNA export factors. Here we show that hepatitis B virus post-transcriptional element (PRE) is one such element, and using PRE several new cellular mRNA export factors were identified. We found that PRE drastically enhances the cytoplasmic accumulation of cDNA transcripts independent of any viral protein. Systematic deletion analysis revealed the existence of a 116 nt functional Sub-Element of PRE (SEP1). The RNP that forms on the SEP1 RNA was affinity purified, in which TREX components as well as several other proteins were identified. TREX components and the SEP1-associating protein ZC3H18 are required for SEP1-mediated mRNA export. Significantly, ZC3H18 directly binds to the SEP1 RNA, interacts with TREX and is required for stable association of TREX with the SEP1-containing mRNA. Requirements for SEP1-mediated mRNA export are similar to those for splicing-dependent mRNA export. Consistent with these similarities, several SEP1-interacting proteins, including ZC3H18, ARS2, Acinus and Brr2, are required for efficient nuclear export of polyA RNAs. Together, our data indicate that SEP1 enhances mRNA export by recruiting TREX via ZC3H18. The new mRNA export factors that we identified might be involved in cap- and splicing-dependent TREX recruitment to cellular mRNAs. PMID:24782531

Socio-economic disparities in the diet of French children and adolescents: a multidimensional issue.

PubMed

Drouillet-Pinard, Peggy; Dubuisson, Carine; Bordes, Isabelle; Margaritis, Irène; Lioret, Sandrine; Volatier, Jean-Luc

2017-04-01

The present research aimed to study the multidimensionality of the link between dietary intake and socio-economic position (SEP) in a representative sample of French children and adolescents, using a variety of SEP indicators. Data from the second French national food consumption survey (INCA2) were used. Information on food consumption was collected using a 7d food record and SEP data (occupation, education, income, household wealth indices) using questionnaires. Multivariable linear regression analyses were performed separately in children and adolescents to assess the relationships between dietary components (food groups and macronutrients) and each dimension of SEP. The INCA2 survey, France. A representative sample of French children (3-10 years of age; n 574) and adolescents (11-17 years of age; n 881). Compared with children from a higher SEP, those from a lower SEP had lower intakes of fruit and vegetables, yoghurts and confectionery and higher intakes of starchy foods, meat, milk, sugar-sweetened beverages and pizzas/sandwiches. Similar results were observed in adolescents for fruit and vegetables, yoghurts and sugar-sweetened beverages. Adolescents also had lower intakes of cakes/pastries and higher intakes of processed meat and dairy desserts. Neither energy nor protein intake was associated with SEP. Adolescents from a lower SEP had higher carbohydrate and lower lipid intakes. Overall, these findings were consistent across the various dimensions of SEP, but the gradient was steeper depending on the caregiver's educational level. This research highlights the need for specific messages to help poorly educated families adopt good eating habits.

Prediction of Summer Extreme Precipitation over the Middle and Lower Reaches of the Yangtze River Basin

NASA Astrophysics Data System (ADS)

Liu, L.; Ning, L.; Liu, J.; Yan, M.; Sun, W.

2017-12-01

Abstract: Summer extreme precipitation (SEP) often causes severe landslide, debris flow and floods over the middle and lower reaches of the Yangtze River Basin(MLYRB), so skillful prediction of the SEP is critical to the future climate adaptions and mitigations. In this work, the characteristic region over the MLYRB (27°N-32°N,108°1-118°E) is defined by the spatial mode of the rotated empirical orthogonal functions (REOF) of SEP over the China from 1961 to 2014. A physics-based empirical model (PEM) of SEP predictions is built with two preceding predictors with significant physical influences on the SEP over the MLYRB. The first predictor is the spring sea surface temperature (SST) over the Northern Indian Ocean (20°S-20°N,50°E-95°E), and the second predictor is the spring sea surface pressure (SLP) over the Aleutian Island (50°N-70°N,160°E-160°W). Analyses of physical mechanism show that when the spring SST over the Northern Indian Ocean is higher, the South Asian High (SAH) extends to the east and the western Pacific sub-tropical high (WPSH) extends to the west, therefore, the generated secondary circulation induces anomalous upward motions and more water vapor transportation to the MLYRB, resulting more SEP. Meanwhile, when the spring SLP over the Aleutian Island is lower, the also WPSH extends to the west, which leads to a negative omega anomaly centered the MLYRB and more water vapor transportation to the MLYRB, resulting in more SEP. The regression model is built using the data from a training period from 1961 to 1999 with correlation coefficient skill of 0.57 (p<0.01) for prediction of SEP in 1961-1999. The independent forecast of the PEM shows that it is skillful in SEP prediction with the correlation coefficient between observed SEP and model-simulated SEP over the validation period 2000-2014 is 0.51 (p<0.05). This finding shows that the preceding spring SST and SLP can provide useful information for prediction of SEP, and the methodology proposed here can be applied to a wide range of climate prediction studies. The future improvements are also discussed.

Wearable Sensor Technology Efficacy in Peripheral Vascular Disease (wSTEP): A Randomized Controlled Trial.

PubMed

Normahani, Pasha; Kwasnicki, Richard; Bicknell, Colin; Allen, Louise; Jenkins, Mike P; Gibbs, Richard; Cheshire, Nicholas; Darzi, Ara; Riga, Celia

2017-05-11

To evaluate the effect of using wearable activity monitors (WAMs) in patients with intermittent claudication (IC) within a single-center randomized controlled trial. WAMs allow users to set daily activity targets and monitor their progress. They may offer an alternative treatment to supervised exercise programs (SEPs) for patients with IC. Thirty-seven patients with IC were recruited and randomized into intervention or control group. The intervention consisted of a feedback-enabled, wrist-worn activity monitor (WAM) in addition to access to SEP. The control group was given access to SEP only. The outcome measures were maximum walking distance (MWD), claudication distance (CD), and quality of life as measured by the VascuQol questionnaire. Participants were assessed upon recruitment, and at 3, 6, and 12 months. Patients in the WAM group showed significant improvement in MWD at 3 and 6 months (80-112 m, to 178 m; P < 0.001), which was sustained at 12 months. The WAM group also increased CD (40 vs 110 m; P < 0.001) and VascuQol score (4.7 vs 5.8; P = 0.004). The control group saw a temporary increase in VascuQol score at 6 months (4.5 vs 4.7; P = 0.028), but no other improvements in MWD or CD were observed. Significantly higher improvements in MWD were seen in the WAM group compared with that in the control group at 6 months (82 vs -5 m; P = 0.009, r = 0.47) and 12 months (69 vs 7.5 m; P = 0.011, r = 0.52). The study demonstrates the significant, sustained benefit of WAM-led technologies for patients with IC. This potentially resource-sparing intervention is likely to provide a valuable adjunct or alternative to SEP.

Semiannual Technical Summary, 1 April-30 September 1993

DTIC Science & Technology

1993-12-01

Hardware failure 11 Jul 2200 - Hardware failure 12 Jul - 0531 Hardware failure 12 Jul 0744 - 1307 Hardware service 1OAug 0821 - 1514 Line failure 29 Aug...1000 - Line failure 30 Aug - 1211 Line failure 08 Sep 1518 - Line failure 09 Sep - 0428 Line failure 10 Sep 0821 - 1030 Hardware failure 18 Sep 0817...reair. Between 8 September 1306 hrs and 9 September 0428 hre all communications systems wene affected (13.5 hrs). Reduced 01B performance started 10

Divisome-dependent subcellular localization of cell-cell joining protein SepJ in the filamentous cyanobacterium Anabaena.

PubMed

Ramos-León, Félix; Mariscal, Vicente; Frías, José E; Flores, Enrique; Herrero, Antonia

2015-05-01

Heterocyst-forming cyanobacteria are multicellular organisms that grow as filaments that can be hundreds of cells long. Septal junction complexes, of which SepJ is a possible component, appear to join the cells in the filament. SepJ is a cytoplasmic membrane protein that contains a long predicted periplasmic section and localizes not only to the cell poles in the intercellular septa but also to a position similar to a Z ring when cell division starts suggesting a relation with the divisome. Here, we created a mutant of Anabaena sp. strain PCC 7120 in which the essential divisome gene ftsZ is expressed from a synthetic NtcA-dependent promoter, whose activity depends on the nitrogen source. In the presence of ammonium, low levels of FtsZ were produced, and the subcellular localization of SepJ, which was investigated by immunofluorescence, was impaired. Possible interactions of SepJ with itself and with divisome proteins FtsZ, FtsQ and FtsW were investigated using the bacterial two-hybrid system. We found SepJ self-interaction and a specific interaction with FtsQ, confirmed by co-purification and involving parts of the SepJ and FtsQ periplasmic sections. Therefore, SepJ can form multimers, and in Anabaena, the divisome has a role beyond cell division, localizing a septal protein essential for multicellularity. © 2015 John Wiley & Sons Ltd.

Dependence of the Peak Fluxes of Solar Energetic Particles on CME 3D Parameters from STEREO and SOHO

DOE Office of Scientific and Technical Information (OSTI.GOV)

Park, Jinhye; Moon, Y.-J.; Lee, Harim, E-mail: jinhye@khu.ac.kr

We investigate the relationships between the peak fluxes of 18 solar energetic particle (SEP) events and associated coronal mass ejection (CME) 3D parameters (speed, angular width, and separation angle) obtained from SOHO , and STEREO-A / B for the period from 2010 August to 2013 June. We apply the STEREO CME Analysis Tool (StereoCAT) to the SEP-associated CMEs to obtain 3D speeds and 3D angular widths. The separation angles are determined as the longitudinal angles between flaring regions and magnetic footpoints of the spacecraft, which are calculated by the assumption of a Parker spiral field. The main results are asmore » follows. (1) We find that the dependence of the SEP peak fluxes on CME 3D speed from multiple spacecraft is similar to that on CME 2D speed. (2) There is a positive correlation between SEP peak flux and 3D angular width from multiple spacecraft, which is much more evident than the relationship between SEP peak flux and 2D angular width. (3) There is a noticeable anti-correlation ( r = −0.62) between SEP peak flux and separation angle. (4) The multiple-regression method between SEP peak fluxes and CME 3D parameters shows that the longitudinal separation angle is the most important parameter, and the CME 3D speed is secondary on SEP peak flux.« less

Particulate Air Pollution and Socioeconomic Position in Rural and Urban Areas of the Northeastern United States

PubMed Central

Brochu, Paul J.; Yanosky, Jeff D.; Paciorek, Christopher J.; Schwartz, Joel; Chen, Jarvis T.; Herrick, Robert F.

2011-01-01

Objectives. Although differential exposure by socioeconomic position (SEP) to hazardous waste and lead is well demonstrated, there is less evidence for particulate air pollution (PM), which is associated with risk of death and illness. This study determined the relationship of ambient PM and SEP across several spatial scales. Methods. Geographic information system-based, spatio-temporal models were used to predict PM in the Northeastern United States. Predicted concentrations were related to census tract SEP and racial composition using generalized additive models. Results. Lower SEP was associated with small, significant increases in PM. Annual PM10 decreased between 0.09 and 0.93 micrograms per cubic meter and PM2.5 between 0.02 and 0.94 micrograms per cubic meter for interquartile range increases in income. Decrements in PM with SEP increased with spatial scale, indicating that between-city spatial gradients were greater than within-city differences. The PM–SEP relation in urban tracts was not substantially modified by racial composition. Conclusions. Lower compared with higher SEP populations were exposed to higher ambient PM in the Northeastern United States. Given the small percentage change in annual PM2.5 and PM10, SEP was not likely a major source of confounding in epidemiological studies of PM, especially those conducted within a single urban/metropolitan area. PMID:21836114

Incorporating science and engineering practices into preservice secondary science teachers' planning practices: Testing the efficacy of an intervention

NASA Astrophysics Data System (ADS)

Wargo, Brian M.

The New Standards Framework (NRC, 2012) explicitly calls for teachers to engage students in science and engineering practices (SEPs) as they develop knowledge of scientific phenomena and canonical disciplinary ideas. This study analyzed six pre-service secondary science teachers' (PSSSTs') incorporation of SEPs into their planning practices before, during, and after an instructional intervention. The intervention, which was nested into an instructional methods course, supported the PSSSTs by representing the practices they were to engage their own students with. The PSSSTs were then able to decompose and approximate those scientific practices in their lesson planning, thereby developing pedagogical design capacity (PDC). The PSSSTs were interviewed to determine what affordances and constraints they felt when planning for incorporating SEPs into their lesson planning. Analysis of the lesson plans showed that 50% of the PSSSTs incorporated SEPs into their lesson plans when only provided a written description of the SEPs and prompted to do so. During the instructional intervention, 83% of the PSSSTs incorporated SEPs into their lesson plans. After the instructional intervention, the PSSSTs were no longer required to incorporate SEPs into their lesson planning nor were they required to hand in lesson plans for a grade. Instead, they wrote lesson plans for their cooperating teachers and for their own use. Surprisingly, the PSSSTs not only continued to incorporate SEPs into their lessons, but did so more completely by incorporating a diversity of sub-SEPs and more of them in their lessons. This is significant because this may indicate that the instructional intervention has longevity. Interview data suggests that PSSSTs experience both internal and external affordances and constrains when attempting to incorporate SEPs into their lesson planning. Three categories of issues (epistemic, logistical, and curricular) emerged in the results and influence how teachers interact with the SEPs as they plan lessons. This study reiterates the need for teacher educators to engage in instruction that represents aspects of scientific practice, allows for its decomposition, and engages pre-service teachers in approximating those practices.

Maintenance and Variations of Atmospheric Subsidence in the Southeast Pacific

NASA Astrophysics Data System (ADS)

Wang, C.; Lee, S.; Mechoso, C. R.; Enfield, D. B.

2010-12-01

The southeastern tropical Pacific (SEP) is characterized by large-scale subsidence, extensive and persistent stratocumulus cloud, and cold SST. The subtropical high in the South Pacific and subsidence over the SEP during the austral summer are related to the monsoonal heating over South America. Previous studies demonstrate that during the austral summer, Rossby wave response to heating associated with the South American monsoon system interacting with the midlatitude westerlies produces descending motion to the west of the South American heating, i.e., over the SEP. The Sverdrup balance demands the existence of equatorward flow beneath the region of descent, closing off the South Pacific subtropical anticyclone on its eastern flank. During seasons other than the austral summer, when convective activity over South America is weaker, other processes must be responsible for maintaining and varying the subsidence over the SEP. This paper shows that the Atlantic warm pool (AWP) is responsible for the subsidence in the SEP during the austral winter and spring. The AWP is a large body of warm water comprising the Gulf of Mexico, the Caribbean Sea, and the western tropical North Atlantic. AWP variability occurs on seasonal, interannual, and multidecadal timescales. The AWP reaches its maximum size in the boreal late summer and early fall, with large AWPs being almost three times larger than small ones. The warm pool alternates with South America as the seasonal heating source for the Hadley circulation in the Western Hemisphere. During the boreal summer and fall, a strong Hadley circulation emanates from the AWP and forks into the subsidence region of the SEP. The anomalous warm pool index is positively correlated with rainfall anomalies over the SEP where the drizzle under the stratus cloud deck appears. Large (small) warm pools strengthen (weaken) the summer Hadley circulation that emanates from the region of the warm pool into the SEP. This will change the subsidence over the SEP and thus the stratus cloud and drizzle. Atmospheric GCM and simple models are further used to demonstrate the remote and inter-hemispheric response of the AWP to the SEP; that is, the AWP contributes to sinking over the SEP and hence the stratus cloud in the region.

Critical evaluation of the ability of sequential extraction procedures to quantify discrete forms of selenium in sediments and soils.

PubMed

Wright, Michael T; Parker, David R; Amrhein, Christopher

2003-10-15

Sequential extraction procedures (SEPs) have been widely used to characterize the mobility, bioavailibility, and potential toxicity of trace elements in soils and sediments. Although oft-criticized, these methods may perform best with redox-labile elements (As, Hg, Se) for which more discrete biogeochemical phases may arise from variations in oxidation number. We critically evaluated two published SEPs for Se for their specificity and precision by applying them to four discrete components in an inert silica matrix: soluble Se(VI) (selenate), Se(IV) (selenite) adsorbed onto goethite, elemental Se, and a metal selenide (FeSe; achavalite). These were extracted both individually and in a mixed model sediment. The more selective of the two procedures was modified to further improve its selectivity (SEP 2M). Both SEP 1 and SEP 2M quantitatively recovered soluble selenate but yielded incomplete recoveries of adsorbed selenite (64% and 81%, respectively). SEP 1 utilizes 0.1 M K2S2O8 to target "organically associated" Se, but this extractant also solubilized most of the elemental (64%) and iron selenide (91%) components of the model sediment. In SEP 2M, the Na2SO3 used in step III is effective in extracting elemental Se but also extracted 17% of the Se from the iron selenide, such that the elemental fraction would be overestimated should both forms coexist. Application of SEP 2M to eight wetland sediments further suggested that the Na2SO3 in step III extracts some organically associated Se, so a NaOH extraction was inserted beforehand to yield a further modification, SEP 2OH. Results using this five-step procedure suggested that the four-step SEP 2M could overestimate elemental Se by as much as 43% due to solubilization of organic Se. Although still imperfect in its selectivity, SEP 20H may be the most suitable procedure for routine, accurate fractionation of Se in soils and sediments. However, the strong oxidant (NaOCl) used in the final step cannot distinguish between refractory organic forms of Se and pyritic Se that might form under sulfur-reducing conditions.

The impact of lifecourse socioeconomic position on cardiovascular disease events in African Americans: the Jackson Heart Study.

PubMed

Gebreab, Samson Y; Diez Roux, Ana V; Brenner, Allison B; Hickson, DeMarc A; Sims, Mario; Subramanyam, Malavika; Griswold, Michael E; Wyatt, Sharon B; James, Sherman A

2015-05-27

Few studies have examined the impact of lifecourse socioeconomic position (SEP) on cardiovascular disease (CVD) risk among African Americans. We used data from the Jackson Heart Study (JHS) to examine the associations of multiple measures of lifecourse SEP with CVD events in a large cohort of African Americans. During a median of 7.2-year follow-up, 362 new or recurrent CVD events occurred in a sample of 5301 participants aged 21 to 94. Childhood SEP was assessed by using mother's education, parental home ownership, and childhood amenities. Adult SEP was assessed by using education, income, wealth, and public assistance. Adult SEP was more consistently associated with CVD risk in women than in men: age-adjusted hazard ratios for low versus high income (95% CIs), 2.46 (1.19 to 5.09) in women and 1.50 (0.87 to 2.58) in men, P for interaction=0.1244, and hazard ratio for low versus high wealth, 2.14 (1.39 to 3.29) in women and 1.06 (0.62 to 1.81) in men, P for interaction=0.0224. After simultaneous adjustment for all adult SEP measures, wealth remained a significant predictor of CVD events in women (HR=1.73 [1.04, 2.85] for low versus high). Education and public assistance were less consistently associated with CVD. Adult SEP was a stronger predictor of CVD events in younger than in older participants (HR for high versus low summary adult SEP score 3.28 [1.43, 7.53] for participants ≤50 years, and 1.90 (1.36 to 2.66) for participants >50 years, P for interaction 0.0846). Childhood SEP was not associated with CVD risk in women or men. Adult SEP is an important predictor of CVD events in African American women and in younger African Americans. Childhood SEP was not associated with CVD events in this population. © 2015 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley Blackwell.

Associations of socioeconomic position in childhood and young adulthood with cardiometabolic risk factors: the Jerusalem Perinatal Family Follow-Up Study.

PubMed

Savitsky, B; Manor, O; Friedlander, Y; Burger, A; Lawrence, G; Calderon-Margalit, R; Siscovick, D S; Enquobahrie, D A; Williams, M A; Hochner, H

2017-01-01

Several stages in the life course have been identified as important to the development of cardiovascular disease. This study aimed to assess the associations of childhood and adulthood socioeconomic position (SEP) and social mobility with cardiometabolic risk factors (CMRs) later in life. We conducted follow-up examinations of 1132 offspring, aged 32, within a population-based cohort of all births in Jerusalem from 1974 to 1976. SEP was indicated by parents' occupation and education, and adulthood SEP was based on offspring's occupation and education recorded at age 32. Linear regression models were used to investigate the associations of SEP and social mobility with CMRs. Childhood-occupational SEP was negatively associated with body mass index (BMI; β=-0.29, p=0.031), fat percentage (fat%; β=-0.58, p=0.005), insulin (β=-0.01, p=0.031), triglycerides (β=-0.02, p=0.024) and low-density lipoprotein cholesterol (LDL-C; β=-1.91, p=0.015), independent of adulthood SEP. Adulthood-occupational SEP was negatively associated with waist-to-hip ratio (WHR; β=-0.01, p=0.002), and positively with high-density lipoprotein cholesterol (HDL-C; β=0.87, p=0.030). Results remained similar after adjustment for smoking and inactivity. Childhood-educational SEP was associated with decreased WHR and LDL-C level (p=0.0002), and adulthood-educational SEP was inversely associated with BMI (p=0.001), waist circumference (p=0.008), WHR (p=0.001) and fat% (p=0.0002) and positively associated with HDL-C (p=0.030). Additionally, social mobility (mainly upward) was shown to have adverse cardiometabolic outcomes. Both childhood and adulthood SEP contribute independently to CMR. The match-mismatch hypothesis may explain the elevated CMRs among participants experiencing social mobility. Identification of life-course SEP-related aspects that translate into social inequality in cardiovascular risk may facilitate efforts for improving health and for reducing disparities in cardiovascular disease. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

Social Network Analysis of the Farabi Exchange Program: Student Mobility

ERIC Educational Resources Information Center

Ugurlu, Zeynep

2016-01-01

Problem Statement: Exchange programs offer communication channels created through student and instructor exchanges; a flow of information takes place through these channels. The Farabi Exchange Program (FEP) is a student and instructor exchange program between institutions of higher education. Through the use of social network analysis and…

Internal Rate of Return in Defense Analysis. Presented at the Annual Cost Analysis Symposium (27th), held at Leesburg, VA, on 8-11 Sep 1993

DTIC Science & Technology

1993-09-11

it has traditionally been presented. The following cash flows also trigger "IRR incalculable-NPV diverging from zero" in the DCF program : Projecta r 0... program disapproval or cancellation is inherent in defense analyses, thus the emphasis on "affordability,’ e.g., lower cost. A final difficulty with using...percent. (With the DCF program , it makes no difference which one you use.) See Table 7 and Figure 2. Project Year 0 Year I Year 2 NPV @ 10% 1IRRs’ DCF

A Goal Programming R&D (Research and Development) Project Funding Model of the U.S. Army Strategic Defense Command Using the Analytic Hierarchy Process.

DTIC Science & Technology

1987-09-01

A187 899 A GOAL PROGRANNIN R&D (RESEARCH AND DEVELOPMENT) 1/2 PROJECT FUNDING MODEL 0 (U) NAVAL POSTGRADUATE SCHOOL MONTEREY CA S M ANDERSON SEP 87...PROGRAMMING R&D PROJECT FUNDING MODEL OF THE U.S. ARMY STRATEGIC DEFENSE COMMAND USING THE ANALYTIC HIERARCHY PROCESS by Steven M. Anderson September 1987...jACCESSION NO TITI E (Influde Securt ClauAIcatsrn) A Goal Programming R&D Project Funding Model of the U.S. Army Strategic Defense Command Using the

The real-time SEP forecasting tools of the 'HESPERIA' HORIZON 2020 project

NASA Astrophysics Data System (ADS)

Malandraki, Olga E.; Nunez, Marlon; Heber, Bernd; Labrenz, Johannes; Posner, Arik; Milas, Nick; Tsiropoula, Georgia; Pavlos, Evgenios; Sarlanis, Christos

2017-04-01

In this study, we describe the two real-time prediction tools, that have been developed in the framework of the HESPERIA project based upon the proven concepts UMASEP and REleASE. A major impact on human and robotic space exploration activities is the sudden and prompt occurrence of solar energetic ion events. The fact that near-relativistic electrons (1 MeV electrons have 95% of the speed of light) travel faster than ions (30 MeV protons have 25% of the speed of light) and are always present in Solar Energetic Particle (SEP) events can be used to forecast the arrival of protons from SEP events with real-time measurements of near relativistic electrons. The faster electrons arrive at L1 30 to 90 minutes before the slower protons. The Relativistic Electron Alert System for Exploration (REleASE) forecasting scheme (Posner, 2007) uses this effect to predict the proton flux by utilizing the actual electron flux and the increase of the electron flux in the last 60 minutes. In the framework of the HESPERIA project, a clone of the REleASE system was built in the open source programming language PYTHON. The same forecasting principle with use of the same forecasting matrices were in addition adapted to real-time electron flux measurements from the Electron, Proton & Alpha Monitor (EPAM) onboard the Advanced Composition Explorer (ACE). It is shown, that the REleASE forecasting scheme can be adapted to work with any near relativistic electron flux measurements. Solar energetic particles (SEPs) are sometimes energetic enough and the flux is high enough to cause air showers in the stratosphere and in the troposphere, which are an important ionization source in the atmosphere. >500 MeV solar protons are so energetic that they usually have effects on the ground, producing what is called a Ground Level Enhancement (GLE) event. Within the HESPERIA project a predictor of >500 SEP proton events at the near-earth (e.g. at geostationary orbit) has been developed. In order to predict these events, the UMASEP scheme (Núñez, 2011, 2015) has been used. UMASEP makes a lag-correlation of solar electromagnetic (EM) flux with the particle flux at near-earth. If the correlation is high, the model infers that there is a magnetic connection through which particles are arriving. If, additionally, the intensity of the flux of the associated solar event is also high, then the UMASEP scheme issues a SEP prediction. In the case of the prediction of >500 MeV SEP events, the implemented system, called UMASEP-500, correlates X-ray flux with each of the differential proton fluxes measured by the GOES satellites, and with each of the neutron density fluxes collected by neutron monitor stations around the world. When the correlation estimation surpasses a threshold, and the associated flare is greater than a specific X-ray peak flux, a >500 MeV SEP forecast is issued. Both forecasting tools are operational under the HESPERIA server maintained at the National Observatory of Athens. Acknowledgement: This project has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement No 637324 (HESPERIA project).

Testicular cancer: A narrative review of the role of socioeconomic position from risk to survivorship

PubMed Central

Richardson, Lisa C.; Neri, Antonio J.; Tai, Eric; Glenn, Jeffrey D.

2015-01-01

Background Testicular cancer (TC) is one of the most curable cancers. Given survival rates of close to 100% with appropriate therapy, ensuring proper treatment is essential. We reviewed and summarized the literature on the association of socioeconomic position (SEP) along the cancer control spectrum from risk factors to survivorship. Methods We searched PubMed from 1966 to 2011 using the following terms: testicular cancer, testicular neoplasm, poverty, and socioeconomic factors, retrieving 119 papers. After excluding papers for the non-English (10) language and non-relevance (46), we reviewed 63 papers. We abstracted information on socioeconomic position (SEP), including occupation, education, income, and combinations of the 3. Five areas were examined: risk factors, diagnosis, treatment, survival, and survivorship. Results Most studies examined area-based measures, not individual measures of SEP. The majority of studies found an increased risk of developing TC with high SEP though recent papers have indicated increased risk in low-income populations. Regarding diagnosis, recent papers have indicated that lower levels of education and SEP are risk factors for later-stage TC diagnosis and hence higher TC mortality. For treatment, 1 study that examined the use of radiation therapy (RT) in stage I seminoma reported that living in a county with lower educational attainment led to lower use of RT. For survival (mortality), several studies found that men living in lower SEP geographic areas experience lower survival and higher mortality. Conclusion The strongest evidence for SEP impact on testicular germ cell tumor (TGCT) was found for the risk of developing cancer as well as survival. The association of SEP with TGCT risk appears to have changed over the last decade. Given the highly curable nature of TGCT, more research is needed to understand how SEP impacts diagnosis and treatment for TGCT and to design interventions to address disparities in TGCT outcomes and SEP. Published by Elsevier Inc. PMID:22127018

Type III Radio Burst Duration and SEP Events

NASA Technical Reports Server (NTRS)

Gopalswamy, N.; Makela, P.; Xie, H.

2010-01-01

Long-duration (>15 min), low-frequency (<14 MHz) type III radio bursts have been reported to be indicative of solar energetic particle events. We measured the durations of type III bursts associated with large SEP events of solar cycle 23. The Type III durations are distributed symmetrically at 1 MHz yielding a mean value of approximately 33 min (median = 32 min) for the large SEP events. When the SEP events with ground level enhancement (GLE,) are considered, the distribution is essentially unchanged (mean = 32 min, median = 30 min). To test the importance of type III bursts in indicating SEP events, we considered a set of six type III bursts from the same active region (AR 10588) whose durations fit the "long duration" criterion. We analyzed the coronal mass ejections (CMEs), flares, and type II radio bursts associated with the type III bursts. The CMEs were of similar speeds and the flares are also of similar size and duration. All but one of the type III bursts was not associated with a type II burst in the metric or longer wavelength domains. The burst without type II burst also lacked a solar energetic particle (SEP) event at energies >25 MeV. The 1-MHz duration of the type III burst (28 rein) is near the median value of type III durations found for gradual SEP events and ground level enhancement (GLE) events. Yet, there was no sign of SEP events. On the other hand, two other type III bursts from the same active region had similar duration but accompanied by WAVES type 11 bursts; these bursts were also accompanied by SEP events detected by SOHO/ERNE. This study suggests that the type III burst duration may not be a good indicator of an SEP event, consistent with the statistical study of Cliver and Ling (2009, ApJ ).

A High Power Solar Electric Propulsion - Chemical Mission for Human Exploration of Mars

NASA Technical Reports Server (NTRS)

Burke, Laura M.; Martini, Michael C.; Oleson, Steven R.

2014-01-01

Recently Solar Electric Propulsion (SEP) as a main propulsion system has been investigated as an option to support manned space missions to near-Earth destinations for the NASA Gateway spacecraft. High efficiency SEP systems are able to reduce the amount of propellant long duration chemical missions require, ultimately reducing the required mass delivered to Low Earth Orbit (LEO) by a launch vehicle. However, for long duration interplanetary Mars missions, using SEP as the sole propulsion source alone may not be feasible due to the long trip times to reach and insert into the destination orbit. By combining an SEP propulsion system with a chemical propulsion system the mission is able to utilize the high-efficiency SEP for sustained vehicle acceleration and deceleration in heliocentric space and the chemical system for orbit insertion maneuvers and trans-earth injection, eliminating the need for long duration spirals. By capturing chemically instead of with low-thrust SEP, Mars stay time increases by nearly 200 days. Additionally, the size the of chemical propulsion system can be significantly reduced from that of a standard Mars mission because the SEP system greatly decreases the Mars arrival and departure hyperbolic excess velocities (V(sub infinity)).

Effect of heteroscedasticity treatment in residual error models on model calibration and prediction uncertainty estimation

NASA Astrophysics Data System (ADS)

Sun, Ruochen; Yuan, Huiling; Liu, Xiaoli

2017-11-01

The heteroscedasticity treatment in residual error models directly impacts the model calibration and prediction uncertainty estimation. This study compares three methods to deal with the heteroscedasticity, including the explicit linear modeling (LM) method and nonlinear modeling (NL) method using hyperbolic tangent function, as well as the implicit Box-Cox transformation (BC). Then a combined approach (CA) combining the advantages of both LM and BC methods has been proposed. In conjunction with the first order autoregressive model and the skew exponential power (SEP) distribution, four residual error models are generated, namely LM-SEP, NL-SEP, BC-SEP and CA-SEP, and their corresponding likelihood functions are applied to the Variable Infiltration Capacity (VIC) hydrologic model over the Huaihe River basin, China. Results show that the LM-SEP yields the poorest streamflow predictions with the widest uncertainty band and unrealistic negative flows. The NL and BC methods can better deal with the heteroscedasticity and hence their corresponding predictive performances are improved, yet the negative flows cannot be avoided. The CA-SEP produces the most accurate predictions with the highest reliability and effectively avoids the negative flows, because the CA approach is capable of addressing the complicated heteroscedasticity over the study basin.

Near East/North Africa Report, Number 2626

DTIC Science & Technology

1982-09-24

INTERNATIONAL, 29 Aug 82) EGYPT Mubarak’s Remarks at NDP Meeting ( Ibrahim Sa’dah; MAY, 6 Sep 82) ’Ali Interviewed by ’AL-MAJALLAH’ (Kamal Hasan ’Ali...Interview; AL-MAJALLAH, 4-10 Sep 82) . ’AL-AHRAM’ Comment on Reagan Initiative ( Ibrahim Nafi*; AL-AHRAM, 6 Sep 82) Talks Held With Romanian Deputy...Muslimedia, London 1982 CSO: 4600/753 EGYPT MUBARAK’S REMARKS AT NDP MEETING PM091223 Cairo MAY in Arabic 6 Sep 82 p 1 [Report by Ibrahim

F-22 Increment 3.2B Modernization (F-22 Inc 3.2B Mod)

DTIC Science & Technology

2013-12-01

MAR 2016 SEP 2016 SEP 2016 (Ch-1) Full Rate Production JAN 2018 JAN 2018 JUL 2018 JUL 2018 (Ch-1) Required Assets Available ( RAA ) MAR 2019 MAR 2019 SEP...2019 SEP 2019 (Ch-1) Change Explanations (Ch-1) The Milestone C, Full Rate Production, and Required Assets Available ( RAA ) current estimates changed...successful. Memo RAA is defined as six aircraft and associated support equipment. F-22 Inc 3.2B Mod December 2013 SAR April 16, 2014 17:04:43

Comparison of the coronal mass ejection shock acceleration of three widespread SEP events during solar cycle 24

NASA Astrophysics Data System (ADS)

Xie, H.; Mäkelä, P.; St. Cyr, O. C.; Gopalswamy, N.

2017-07-01

We studied three solar energetic particle (SEP) events observed on 14 August 2010, 3 November 2011, and 5 March 2013 by Solar Terrestrial Relations Observatory (STEREO) A, B, and near-Earth (L1) spacecraft with a longitudinal distribution of particles >90°. Using a forward modeling method combined with extreme ultraviolet and white-light images, we determined the angular extent of the shock, the time and location (cobpoint) of the shock intersection with the magnetic field line connecting to each spacecraft, and compute the shock speed at the cobpoint of each spacecraft. We then examine whether the observations of SEPs at each spacecraft were accelerated and injected by the spatially extended shocks or whether another mechanism such as cross-field transport is required for an alternative explanation. Our analyses results indicate that the SEPs observed at the three spacecraft on 3 November, STEREO B (STB) and L1 on 14 August, and the 5 March SEP event at STEREO A (STA) can be explained by the direct shock acceleration. This is consistent with the observed significant anisotropies, short time delays between particle release times and magnetic connection times, and sharp rises in the SEP time profiles. Cross-field diffusion is the likely cause for the 14 August SEP event observed by STA and the 5 March SEPs observed by STB and L1 spacecraft, as particle observations featured weak electron aniotropies and slow rising intensity profiles. Otherwise, the wide longitudinal spread of these SEP increases would require an existence of a circumsolar shock, which may not be a correct assumption in the corona and heliosphere.

SHOCK CONNECTIVITY IN THE 2010 AUGUST AND 2012 JULY SOLAR ENERGETIC PARTICLE EVENTS INFERRED FROM OBSERVATIONS AND ENLIL MODELING

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bain, H. M.; Luhmann, J. G.; Li, Y.

During periods of increased solar activity, coronal mass ejections (CMEs) can occur in close succession and proximity to one another. This can lead to the interaction and merger of CME ejecta as they propagate in the heliosphere. The particles accelerated in these shocks can result in complex solar energetic particle (SEP) events, as observing spacecraft form both remote and local shock connections. It can be challenging to understand these complex SEP events from in situ profiles alone. Multipoint observations of CMEs in the near-Sun environment, from the Solar Terrestrial Relations Observatory –Sun Earth Connection Coronal and Heliospheric Investigation and themore » Solar and Heliospheric Observatory Large Angle and Spectrometric Coronagraph, greatly improve our chances of identifying the origin of these accelerated particles. However, contextual information on conditions in the heliosphere, including the background solar wind conditions and shock structures, is essential for understanding SEP properties well enough to forecast their characteristics. Wang–Sheeley–Arge WSA-ENLIL + Cone modeling provides a tool to interpret major SEP event periods in the context of a realistic heliospheric model and to determine how much of what is observed in large SEP events depends on nonlocal magnetic connections to shock sources. We discuss observations of the SEP-rich periods of 2010 August and 2012 July in conjunction with ENLIL modeling. We find that much SEP activity can only be understood in the light of such models, and in particular from knowing about both remote and local shock source connections. These results must be folded into the investigations of the physics underlying the longitudinal extent of SEP events, and the source connection versus diffusion pictures of interpretations of SEP events.« less

Paternal Lifelong Socioeconomic Position and Low Birth Weight Rates: Relevance to the African-American Women's Birth Outcome Disadvantage.

PubMed

Collins, James W; Rankin, Kristin M; David, Richard J

2016-08-01

Objectives To determine the relation of paternal lifelong socioeconomic position (SEP) to the racial disparity in low birth weight (<2500 g, LBW) rates. Methods Stratified and multilevel logistic regression analyses were performed on an Illinois transgenerational dataset of infants (1989-1991) and their parents (1956-1976) with appended U.S. census income data. The neighborhood incomes of father's place of residence at the time of his birth and at the time of his infant's birth were used to measure of lifelong SEP. Population attributable risk (PAR) percentages were calculated to estimate the percentage of LBW infants attributable to paternal low SEP. Results In Cook County, infants (n = 10,168) born to fathers with a lifelong high SEP had a LBW rate of 3.7 %. LBW rates rose among infants born to fathers with early-life (n = 7224), adulthood (n = 2913), or lifelong (n = 7288) low SEP: 5.2, 6.9, and 9.3 %, respectively. The adjusted (controlling for maternal demographic characteristics) OR of LBW for fathers with an early-life, adulthood, or lifelong low (compared to lifelong high) SEP equaled 1.4 (1.2, 1.6), 1.5 (1.3, 1.9), and 2.0 (1.7, 2.3), respectively. The PAR percentages of LBW for paternal low SEP were 40 and 9 % among African-American and White mothers, respectively. Among fathers with a lifelong high SEP, the adjusted OR of LBW for African-American (compared to White) mothers was 1.1 (0.7, 1.7). Conclusions Low paternal SEP is a novel risk factor for infant LBW independent of maternal demographic characteristics. This phenomenon is particularly relevant to the African-American women's birth outcome disadvantage.

The Effects of Life Events and Socioeconomic Position in Childhood and Adulthood on Successful Aging.

PubMed

Kok, Almar A L; Aartsen, Marja J; Deeg, Dorly J H; Huisman, Martijn

2017-03-01

Building on social stress theory, this study has 2 aims. First, we aim to estimate the effects of stressful life events in childhood and adulthood on Successful Aging (SA). Second, we examine how unequal exposure to such life events between individuals with different socioeconomic position (SEP) contributes to socioeconomic inequalities in SA. We used 16-year longitudinal data from 2,185 respondents aged 55-85 years in 1992 in the Dutch nationally representative Longitudinal Aging Study Amsterdam. Measurement of SA was based on earlier work, in which we integrated trajectories in 9 indicators of functioning into an index of SA. Using path analysis, we investigated direct and indirect effects of parental and adulthood SEP as well as of self-reported childhood and adulthood life events on SA. Almost all included life events had negative direct effects on SA. Parental SEP had no direct effect on SA, whereas adulthood SEP had. Higher Parental SEP increased the likelihood of parental problems and parental death in childhood, resulting in negative indirect effects on SA. Higher adulthood SEP had both positive and negative indirect effects on SA, through increasing the likelihood of divorce and unemployment, but decreasing the likelihood of occupational disability. SEP and particular stressful life events are largely, but not entirely independent predictors of SA. We found that high and low SEP may increase exposure to particular events that negatively affect SA. Findings suggest that low (childhood) SEP and stressful life events are interrelated factors that may limit individual opportunities to age successfully. © The Author 2016. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Maternal life course socio-economic position and offspring body composition at birth in a multi-ethnic population.

PubMed

Sletner, Line; Jenum, Anne Karen; Mørkrid, Kjersti; Vangen, Siri; Holme, Ingar M; Birkeland, Kåre I; Nakstad, Britt

2014-09-01

Size and body composition at birth may affect long-term health. Mean birthweight and body composition differ between ethnic groups living in Europe. We wanted to explore if this relates to differences in socio-economic conditions in country of origin and over the maternal life course. This is a population-based cohort study of healthy pregnant women living in Oslo, Norway. Data on maternal early life and present socio-economic position (SEP) were collected in early gestation, and SEP scores were extracted through two separate principal components analyses. The associations between maternal present SEP and four different offspring anthropometric measures at birth were assessed separately, stratified by maternal early life SEP (dichotomised score) and Human Development Index (HDI, a country-level socio-economic indicator) in the country of origin [high HDI (Reference), n = 287 and low HDI, n = 250]. A strong positive association between maternal present SEP and offspring birthweight was observed if maternal early life SEP was high, but not if maternal early life SEP was low (P < 0.001 for the interaction term). This interactional effect was observed in both HDI groups. Maternal life course SEP affected offspring birthweight mainly through an effect on length and sum of skin folds. Offspring of mothers with origin from low HDI countries had smaller abdominal circumference, possibly indicating less fat-free mass, regardless of maternal life course SEP. Our results suggest that there are transgenerational effects of maternal past socio-economic conditions on offspring size and body composition at birth that modify the associations with present socio-economic factors. © 2014 John Wiley & Sons Ltd.

The impact of menu energy labelling across socioeconomic groups: A systematic review.

PubMed

Sarink, Danja; Peeters, Anna; Freak-Poli, Rosanne; Beauchamp, Alison; Woods, Julie; Ball, Kylie; Backholer, Kathryn

2016-04-01

Menu energy labelling at point of purchase is gaining traction worldwide, yet the potential impact for different socioeconomic groups is unclear. We aimed to summarise evidence on the effectiveness of menu energy labelling by socioeconomic position (SEP). A systematic search for papers published to September 2015 was conducted using terms for labelling, food outlets, and SEP. Quality of studies was assessed. Results were summarised across stages of an intervention logic pathway. Eighteen papers were identified. Of twelve studies reporting the effect of menu energy labelling in low SEP populations, six reported on purchase outcomes. All but one of these reported no positive effect of the policy for this population. Two of the five studies that compared purchase outcomes of menu labelling across SEP groups reported that the policy was effective overall. These two studies reported either a significant decline in fast food calories purchased from consumers in high (but not low) SEP neighbourhoods or a significantly greater decline in calories purchased among consumers visiting stores in higher SEP neighbourhoods post policy implementation. None of the included papers reached the highest quality score. The current evidence describing the impact of menu energy labelling within or across SEP is limited in quantity and quality. Of the two studies that reported a positive benefit of menu energy labelling overall, both identified a greater effect on fast food purchases among consumers visiting stores in high compared to low SEP neighbourhoods. It is difficult to know whether the absence of effectiveness reported in low SEP populations represents a true lack of effectiveness or is a result of a more general lack of policy effectiveness or the limited quality of the reviewed studies. Copyright © 2016 Elsevier Ltd. All rights reserved.

Implications of improved measurements of the highest energy SEPs by AMS and PAMELA

NASA Astrophysics Data System (ADS)

Whitman, K.; Bindi, V.; Consolandi, C.; Corti, C.; Yamashiro, B.

2017-08-01

Solar energetic particles (SEP) are a key target of heliophysics research, not only as exemplars of particle acceleration and transport processes that are ubiquitous in astrophysical plasmas, but also as the most intense transient radiation hazard for human and robotic space explorers. SEPs are very well-observed by spacecraft covering particle energies below several hundred MeV/nucleon. Multiple missions, stretching back over decades, have yielded a fairly complete description of SEP intensity, energy spectra, and composition up to a few hundred MeV/nucleon. SEP characteristics at higher energies are, by comparison, only poorly understood due to the relative dearth of high-energy measurements. This lack of high energy measurements has contributed to a disagreement within the heliophysics community regarding the source regions and mechanisms that accelerate particles up to GeV energies. In solar cycle 24, the Payload for Antimatter Matter Exploration and Light-nuclei Astrophysics (PAMELA) and the Alpha Magnetic Spectrometer (AMS) have been taking measurements of the highest energy SEPs from ∼ 100 MeV to the GeV. Since the literature has discussed SEP acceleration to GeV energies in terms of Ground Level Enhancements (GLE), we will review the findings for GLEs in solar cycle 23. We will discuss the models and theories that address acceleration up to the GeV and how AMS and PAMELA measurements have the potential to advance the current understanding of SEP acceleration physics. Lastly, only 1-2 GLEs have occurred during solar cycle 24, so we will explore a set of SEP events that were observed in the ⩾100 MeV GOES channels, most of which were also observed by PAMELA and AMS.

Comparison of the Coronal Mass Ejection Shock Acceleration of Three Widespread SEP Events During Solar Cycle 24

NASA Technical Reports Server (NTRS)

Xie, H.; Makela, P.; St. Cyr, O. C.; Gopalswamy, N.

2017-01-01

We studied three solar energetic particle (SEP) events observed on 14 August 2010, 3 November 2011, and 5 March 2013 by Solar Terrestrial Relations Observatory (STEREO) A, B, and near-Earth (L1) spacecraft with a longitudinal distribution of particles greater than 90 degrees. Using a forward modeling method combined with extreme ultraviolet and white-light images, we determined the angular extent of the shock, the time and location (cobpoint) of the shock intersection with the magnetic field line connecting to each spacecraft, and compute the shock speed at the cobpoint of each spacecraft. We then examine whether the observations of SEPs at each spacecraft were accelerated and injected by the spatially extended shocks or whether another mechanism such as cross-field transport is required for an alternative explanation. Our analyses results indicate that the SEPs observed at the three spacecraft on 3 November, STEREO B (STB) and L1 on 14 August, and the 5 March SEP event at STEREO A (STA) can be explained by the direct shock acceleration. This is consistent with the observed significant anisotropies, short time delays between particle release times and magnetic connection times, and sharp rises in the SEP time profiles. Cross-field diffusion is the likely cause for the 14 August SEP event observed by STA and the 5 March SEPs observed by STB and L1 spacecraft, as particle observations featured weak electron anisotropies and slow rising intensity profiles. Otherwise, the wide longitudinal spread of these SEP increases would require an existence of a circumsolar shock, which may not be a correct assumption in the corona and heliosphere.

Discovery of Possible Nova in M31 : P60-M31-080915

NASA Astrophysics Data System (ADS)

Kasliwal, M. M.; Cenko, S. B.; Rau, A.; Ofek, E. O.; Quimby, R.; Kulkarni, S. R.

2008-09-01

On UT 2008 Sep 15.36, P60-FasTING (Palomar 60-inch Fast Transients In Nearby Galaxies) discovered a possible nova in M31 at RA(J2000) = 00:42:51.42, DEC(J2000) = 41:01:54.0, offset from the nucleus by 1.34'E, 14.24'S. P60-M31-080915 has a brightness of g=19.1 +/- 0.2 at discovery (photometric calibration wrt NOMAD catalog). It is further confirmed to rise to g=17.6 on Sep 16.16. It is not detected, with 3-sigma upper limits of g > 20.5, g > 21.0, g > 21.7 on Sep 14.16, Sep 13.39 and Sep 11.39 respectively.

Moderate Intensity Cycling Exercise after Upper Extremity Resistance Training Interferes Response to Muscle Hypertrophy but Not Strength Gains

PubMed Central

Tomiya, Shigeto; Kikuchi, Naoki; Nakazato, Koichi

2017-01-01

The purpose of the present study was to examine the effect of 30-min moderate intensity cycling exercise immediately after upper-body resistance training on the muscle hypertrophy and strength gain. Fourteen subjects were randomly divided between two groups. One group performed moderate intensity (55% of maximum oxygen consumption [VO2max], 30 min) cycle training immediately after arm resistance training as concurrent training (CT; n = 7, age: 21.8 ± 0.7 years, height: 1.68 ± 0.06 m, weight: 60.3 ± 7.4 kg); the second group performed the same endurance and arm RT on separate days as control group (SEP; n=7, age: 22.1 ± 0.7 years, height: 1.76 ± 0.05 m, weight: 63.8 ± 3.6 kg). The supervised progressive RT program was designed to induce muscular hypertrophy (3-5 sets of 10 repetitions) with bilateral arm-curl exercise using 75% of the one repetition maximum (1RM) with 2-min rest intervals. The RT program was performed for 8 weeks, twice per week. Muscle cross-sectional area (CSA), 1RM, and VO2max were measured pre- and post-training. Significant increases in muscle CSA from pre- to post-training were observed in both the SEP (p = 0.001, effect size [ES] = 0.84) and the CT groups (p = 0.004, ES = 0.45). A significant increase in 1RM from pre- to post-training was observed in the SEP (p = 0.025, ES = 0.91) and CT groups (p = 0.001, ES = 2.38). There were no interaction effects (time × group) for CSA, 1RM, or VO2max. A significantly higher percentage change of CSA was observed in the SEP group (12.1 ± 4.9%) compared to the CT group (5.0 ± 2.7%, p = 0.029), but no significant difference was observed in the 1RM (SEP: 19.8 ± 16.8%, CT: 24.3 ± 11.1%). The data suggest that significant improvement of CSA and strength can be expected with progressive resistance training with subsequent endurance exercise performed immediately or on a different day. Changes in CSA might be affected by subsequent cycling exercise after 8 weeks of training. Key points Moderate intensity cycling exercise immediately after upper-body resistance training influences the magnitude of muscle hypertrophy and relative value of CSA changes. There was no statistically significant difference in the % change in 1RM between groups after concurrent strength training and moderate intensity endurance training. Timing of endurance training could alter the degree of muscular growth induced by resistance training. PMID:28912657

Characteristics and enzymatic hydrolysis of cellulose-rich fractions from steam exploded and sequentially alkali delignified bamboo (Phyllostachys pubescens).

PubMed

Sun, Shao-Ni; Cao, Xue-Fei; Zhang, Xue-Ming; Xu, Feng; Sun, Run-Cang; Jones, Gwynn Lloyd

2014-07-01

In this study, cellulose-rich fractions from bamboo were prepared with steam explosion pretreatment (SEP) followed by a successive alkaline delignification to improve the enzymatic digestibility for an efficient bioethanol production. The cellulose-rich fractions obtained were characterized by FT-IR, XRD, CP/MAS (13)C NMR, SEM, and BET surface area. It was found that the SEP alone significantly removed partial hemicelluloses, while the synergistic treatment by SEP and alkaline delignification removed most hemicelluloses and lignin. Results from enzymatic hydrolysis showed that SEP alone improved the enzymatic hydrolysis rate by 7.9-33.1%, while the synergistic treatment by SEP and alkaline delignification enhanced the rate by 45.7-63.9%. The synergistic treatment by SEP at 2.0 MPa for 5 min with water impregnation followed by a successive alkaline delignification with 0.5% NaOH and 70% ethanol containing 1.5% NaOH resulted in a maximum enzymatic hydrolysis rate of 70.6%. Copyright © 2014 Elsevier Ltd. All rights reserved.

Analysis on H Spectral Shape During the Early 2012 SEPs with the PAMELA Experiment

NASA Technical Reports Server (NTRS)

Martucci, Matteo; Boezio, M.; Bravar, U.; Carbone, R.; Christian, E. R.; De Nolfo, G. A.; Merge, M.; Mocchiutti, E.; Munini, R.; Ricci, M.;

Surface electrical properties experiment, part 1. [for measuring lunar surface electrical properties

NASA Technical Reports Server (NTRS)

Kupfer, W. S. (Compiler)

1973-01-01

The design evolution, hardware development, and production history of the surface electrical properties (SEP) experiment are discussed. The SEP transmitter and receiver were designed to be used on the lunar surface during the Apollo 17 mission. The equipment was used to measure lunar surface electrical properties over traverses totalling more than 8 kilometers, for a duration of more than 100 minutes. A comprehensive outline of the techniques, is given along with a simplified detailed breakdown of equipment description and function to outline the principles of operation. A history of the design evolution with trade-off criteria and emphasis on changes caused by decisions reached in solving problems inherent in a fast-paced development program are presented from the viewpoint of overall design concept and in detail for each item of deliverable hardware. There is a brief account of lunar operations.

Reviews Book: The Babylonian Theorem Video Game: BrainBox360 (Physics Edition) Book: Teaching and Learning Science: Towards a Personalized Approach Book: Good Practice in Science Teaching: What Research Has to Say Equipment: PAPERSHOW Equipment: SEP Steady State Bottle Kit Equipment: Sciencescope Datalogging Balance Equipment: USB Robot Arm Equipment: Sciencescope Spectrophotometer Web Watch

NASA Astrophysics Data System (ADS)

2010-07-01

WE RECOMMEND Good Practice in Science Teaching: What Research Has to Say Book explores and summarizes the research Steady State Bottle Kit Another gem from SEP Sciencescope Datalogging Balance Balance suits everyday use Sciencescope Spectrophotometer Device displays clear spectrum WORTH A LOOK The Babylonian Theorem Text explains ancient Egyptian mathematics BrainBox360 (Physics Edition) Video game tests your knowledge Teaching and Learning Science: Towards a Personalized Approach Book reveals how useful physics teachers really are PAPERSHOW Gadget kit is useful but has limitations Robotic Arm Kit with USB PC Interface Robot arm teaches programming WEB WATCH Simple applets teach complex topics

Launch vehicle and power level impacts on electric GEO insertion

NASA Technical Reports Server (NTRS)

Oleson, Steven R.; Myers, Roger M.

1996-01-01

Solar Electric Propulsion (SEP) has been shown to increase net geosynchronous spacecraft mass when used for station keeping and final orbit insertion. The impact of launch vehicle selection and power level on the benefits of this approach were examined for 20 and 25 kW systems launched using the Ariane 5, Atlas IIAR, Long March, Proton, and Sea Launch vehicles. Two advanced on-board propulsion technologies, 5 kW ion and Hall thruster systems, were used to establish the relative merits of the technologies and launch vehicles. GaAs solar arrays were assumed. The analysis identifies the optimal starting orbits for the SEP orbit raising/plane changing while considering the impacts of radiation degradation in the Van Allen belts, shading, power degradation, and oblateness. This use of SEP to provide part of the orbit insertion results in net mass increases of 15 - 38% and 18 - 46% for one to two month trip times, respectively, over just using SEP for 15 years of north/south station keeping. SEP technology was shown to have a greater impact on net masses of launch vehicles with higher launch latitudes when avoidance of solar array and payload degradation is desired. This greater impact of SEP could help reduce the plane changing disadvantage of high latitude launch sites. Comparison with results for 10 and 15 kW systems show clear benefits of incremental increases in SEP power level, suggesting that an evolutionary approach to high power SEP for geosynchronous spacecraft is possible.

The composition of heavy ions in solar energetic particle events

NASA Technical Reports Server (NTRS)

Fan, C. Y.; Gloeckler, G.; Hovestadt, D.

1983-01-01

Recent advances in determining the elemental, charge state, and isotopic composition of or approximate to 1 to or approximate to 20 MeV per nucleon ions in solar energetic particle (SEP) events and outline our current understanding of the nature of solar and interplanetary processes which may explain the observations. Average values of relative abundances measured in a large number of SEP events were found to be roughly energy independent in the approx. 1 to approx. 20 MeV per nucleon range, and showed a systematic deviation from photospheric abundances which seems to be organized in terms of the first ionization potential of the ion. Direct measurements of the charge states of SEPs revealed the surprisingly common presence of energetic He(+) along with heavy ion with typically coronal ionization states. High resolution measurements of isotopic abundance ratios in a small number of SEP events showed these to be consistent with the universal composition except for the puzzling overabundance of the SEP(22)Ne/(20)Ne relative to this isotopes ratio in the solar wind. The broad spectrum of observed elemental abundance variations, which in their extreme result in composition anomalies characteristic of (3)He rich, heavy ion rich and carbon poor SEP events, along with direct measurements of the ionization states of SEPs provided essential information on the physical characteristics of, and conditions in the source regions, as well as important constraints to possible models for SEP production.

Solar Electric and Chemical Propulsion Technology Applications to a Titan Orbiter/Lander Mission

NASA Technical Reports Server (NTRS)

Cupples, Michael

2007-01-01

Several advanced propulsion technology options were assessed for a conceptual Titan Orbiter/Lander mission. For convenience of presentation, the mission was broken into two phases: interplanetary and Titan capture. The interplanetary phase of the mission was evaluated for an advanced Solar Electric Propulsion System (SEPS), while the Titan capture phase was evaluated for state-of-art chemical propulsion (NTO/Hydrazine), three advanced chemical propulsion options (LOX/Hydrazine, Fluorine/Hydrazine, high Isp mono-propellant), and advanced tank technologies. Hence, this study was referred to as a SEPS/Chemical based option. The SEPS/Chemical study results were briefly compared to a 2002 NASA study that included two general propulsion options for the same conceptual mission: an all propulsive based mission and a SEPS/Aerocapture based mission. The SEP/Chemical study assumed identical science payload as the 2002 NASA study science payload. The SEPS/Chemical study results indicated that the Titan mission was feasible for a medium launch vehicle, an interplanetary transfer time of approximately 8 years, an advanced SEPS (30 kW), and current chemical engine technology (yet with advanced tanks) for the Titan capture. The 2002 NASA study showed the feasibility of the mission based on a somewhat smaller medium launch vehicle, an interplanetary transfer time of approximately 5.9 years, an advanced SEPS (24 kW), and advanced Aerocapture based propulsion technology for the Titan capture. Further comparisons and study results were presented for the advanced chemical and advanced tank technologies.

Training Extract, AFSC 113X0B, Flight Engineer, Helicopter Qualified.

DTIC Science & Technology

1982-12-01

TRAINING .................................................................. 1I0 SE. GENERAL rLIGHT RULES A 9 C t | 7. PeRFORM INSPECIIOIS 12 7A... TRAINING .................................................................. lIC 6E. GENERAL FLIGHT RULES A a C...ME"BERS PERFORMING I-A I PROGRAM GENERATED VECTOR IMEMBERS/ NO TYPE VECTOR MEAN - SC DESCRIPTION I TN. SEP J.6 2.J TRAINING EMPHASIS RATINSS I IIOS

Explorations of Psyche and Callisto Enabled by Ion Propulsion

NASA Technical Reports Server (NTRS)

Wenkert, Daniel D.; Landau, Damon F.; Bills, Bruce G.; Elkins-Tanton, Linda T.

2013-01-01

Recent developments in ion propulsion (specifically solar electric propulsion - SEP) have the potential for dramatically reducing the transportation cost of planetary missions. We examine two representative cases, where these new developments enable missions which, until recently, would have required resouces well beyond those allocated to the Discovery program. The two cases of interest address differentiation of asteroids and large icy satellites

Theoretical Technology Research for ISTP/SOLARMAX

NASA Technical Reports Server (NTRS)

Ashour-Abdalla, Maha; Acuna, Mario (Technical Monitor)

2000-01-01

During the last decade, we have been developing theoretical tools to support the scientific objectives of the International Solar Terrestrial Physics (ISTP) program. Results from our mission-oriented theory program have contributed significantly to the development of predictive capabilities by using real upstream solar wind conditions as input to our models and forecasting events observed downstream near Earth. We also developed the capability to unravel the complex information contained in ion velocity distribution functions measured near the Earth to determine their origin and energization process. During solar maximum, solar flares and coronal mass ejections (CMEs) dominate the sun's activity. It is now widely accepted that the impact of CMEs (or magnetic clouds) with the Earth's magnetosphere is the cause of most magnetic storms during solar maximum. One important aspect of a CME is the occurrence of solar energetic particle (SEP) events. During these events, protons, electrons, and heavy ions of solar origin are accelerated to very high energies by shock waves driven out from the sun. We carried out a series of large-scale kinetic (LSK) simulations to model the effect of SEPs on the near-Earth environment and the accessibility of these high-energy particles to the inner magnetosphere. We present the results of these studies.

Does personality influence job acquisition and tenure in people with severe mental illness enrolled in supported employment programs?

PubMed

Fortin, Guillaume; Lecomte, Tania; Corbière, Marc

2017-06-01

When employment difficulties in people with severe mental illness (SMI) occur, it could be partly linked to issues not specific to SMI, such as personality traits or problems. Despite the fact that personality has a marked influence on almost every aspect of work behavior, it has scarcely been investigated in the context of employment for people with SMI. We aimed to evaluate if personality was more predictive than clinical variables of different competitive work outcomes, namely acquisition of competitive employment, delay to acquisition and job tenure. A sample of 82 people with a SMI enrolled in supported employment programs (SEP) was recruited and asked to complete various questionnaires and interviews. Statistical analyses included logistic regressions and survival analyses (Cox regressions). Prior employment, personality problems and negative symptoms are significantly related to acquisition of a competitive employment and to delay to acquisition whereas the conscientiousness personality trait was predictive of job tenure. Our results point out the relevance of personality traits and problems as predictors of work outcomes in people with SMI registered in SEP. Future studies should recruit larger samples and also investigate these links with other factors related to work outcomes.

Head Start Staff Reactions to a Novel Tobacco Intervention: A Qualitative Analysis.

PubMed

Keske, Robyn R; Barker, Kathryn M; Geller, Alan C; Hamasaka, Laura; Sparks, Michael; Moody-Thomas, Sarah; Jolicoeur, Denise; Rees, Vaughan W

2016-11-01

As tobacco use becomes increasingly concentrated in communities of low socio-economic position (SEP), scalable cessation interventions are needed. Head Start programs offer one setting in which a family-focused intervention can be implemented in low SEP communities. We assessed the experiences of Head Start (HS) staff who received training in a pilot motivational interviewing (MI) tobacco intervention, to improve future feasibility. Focus group interviews were conducted with HS staff to assess their reactions to MI training and their use of MI in their work with families. Transcripts were analyzed using thematic analysis and a 4-step approach informed by grounded theory. HS staff reported advantages of MI beyond its use as a tobacco intervention, despite systematic barriers to broad implementation. Facilitators of MI use included enhanced engagement with families, and opportunities for professional development. Barriers to MI use included limited institutional support and low priority for a tobacco intervention among families with pressing social and financial concerns. HS Staff voiced support for broader training in MI interventions in HS programs. System-wide standards to ensure adequate training and support for an MI tobacco intervention were identified as priorities.

Broad Search Solar Electric Propulsion Trajectories to Saturn with Gravity Assists

NASA Technical Reports Server (NTRS)

Lam, Try; Landau, Damon; Strange, Nathan

2009-01-01

Solar electric propulsion (SEP) trajectories to Saturn using multiple gravity assists are explored for the joint NASA and ESA Titan Saturn System Mission study. Results show that these new trajectories enable greater performance compared to chemical propulsion with similar gravity assists or SEP without gravity assists. This paper describes the method used in finding these interplanetary trajectories and examines variations in the performance for different SEP systems, flight times, and flyby sequences. The benefits of the SEP trajectories for a mission to Saturn are also discussed.

Planetary mission requirements, technology and design considerations for a solar electric propulsion stage

NASA Technical Reports Server (NTRS)

Cork, M. J.; Hastrup, R. C.; Menard, W. A.; Olson, R. N.

1979-01-01

High energy planetary missions such as comet rendezvous, Saturn orbiter and asteroid rendezvous require development of a Solar Electric Propulsion Stage (SEPS) for augmentation of the Shuttle-IUS. Performance and functional requirements placed on the SEPS are presented. These requirements will be used in evolution of the SEPS design, which must be highly interactive with both the spacecraft and the mission design. Previous design studies have identified critical SEPS technology areas and some specific design solutions which are also presented in the paper.

Solar Energetic Particles -- A Radiation Hazard to Humans and Hardware in Space

NASA Astrophysics Data System (ADS)

Mewaldt, R. A.

2006-10-01

During large solar energetic particle (SEP) events the intensity of >30 MeV protons in nearby interplanetary space can increase by a million times over the steady intensity of galactic cosmic rays, creating a radiation hazard to both humans and hardware in space. With NASA now committed to sending astronauts to the Moon and possibly on to Mars, outside the protective cover of the Earth's magnetosphere, interest in understanding and forecasting large SEP events has taken on a new sense of urgency. The past solar maximum included four of the top ten SEP events of the space era. Fortunately, the array of spacecraft now in interplanetary space has provided greatly improved measurements of the composition and energy spectra of accelerated ions, leading to fresh insights into the nature of these events. The largest SEP events are accelerated by coronal and interplanetary shocks driven by coronal mass ejections (CMEs) traveling at >2000 km/sec. Although shock acceleration is ubiquitous in nature, its efficiency is highly variable, making it difficult to forecast the onset and evolution of large SEP events. This talk will describe the radiation hazards associated with the largest SEP events, discuss their frequency of occurrence, consider a worst-case SEP event, and describe how the radiation risks can be mitigated.

Cluster fusion-fission dynamics in the Singapore stock exchange

NASA Astrophysics Data System (ADS)

Teh, Boon Kin; Cheong, Siew Ann

2015-10-01

In this paper, we investigate how the cross-correlations between stocks in the Singapore stock exchange (SGX) evolve over 2008 and 2009 within overlapping one-month time windows. In particular, we examine how these cross-correlations change before, during, and after the Sep-Oct 2008 Lehman Brothers Crisis. To do this, we extend the complete-linkage hierarchical clustering algorithm, to obtain robust clusters of stocks with stronger intracluster correlations, and weaker intercluster correlations. After we identify the robust clusters in all time windows, we visualize how these change in the form of a fusion-fission diagram. Such a diagram depicts graphically how the cluster sizes evolve, the exchange of stocks between clusters, as well as how strongly the clusters mix. From the fusion-fission diagram, we see a giant cluster growing and disintegrating in the SGX, up till the Lehman Brothers Crisis in September 2008 and the market crashes of October 2008. After the Lehman Brothers Crisis, clusters in the SGX remain small for few months before giant clusters emerge once again. In the aftermath of the crisis, we also find strong mixing of component stocks between clusters. As a result, the correlation between initially strongly-correlated pairs of stocks decay exponentially with average life time of about a month. These observations impact strongly how portfolios and trading strategies should be formulated.

Overview of atmospheric ionizing radiation (AIR) research: SST-present

NASA Technical Reports Server (NTRS)

Wilson, J. W.; Goldhagen, P.; Rafnsson, V.; Clem, J. M.; De Angelis, G.; Friedberg, W.

2003-01-01

The Supersonic Transport (SST) program, proposed in 1961, first raised concern for the exposure of pregnant occupants by solar energetic particles (SEP), and neutrons were suspected to have a main role in particle propagation deep into the atmosphere. An eight-year flight program confirmed the role of SEP as a significant hazard and of the neutrons as contributing over half of the galactic cosmic ray exposures, with the largest contribution from neutrons above 10 MeV. The FAA Advisory Committee on the Radiobiological Aspects of the SST provided operational requirements. The more recent lowering of ICRP-recommended exposure limits (1990) with the classification of aircrew as "radiation workers" renewed interest in GCR background exposures at commercial flight altitudes and stimulated epidemiological studies in Europe, Japan, Canada and the USA. The proposed development of a High Speed Civil Transport (HSCT) required validation of the role of high-energy neutrons, and this resulted in ER-2 flights at solar minimum (June 1997) and studies on effects of aircraft materials on interior exposures. Recent evaluation of health outcomes of DOE nuclear workers resulted in legislation for health compensation in year 2000 and recent European aircrew epidemiological studies of health outcomes bring renewed interest in aircraft radiation exposures. As improved radiation models become available, it is imperative that a corresponding epidemiological program of US aircrew be implemented. Published by Elsevier Ltd on behalf of COSPAR.

Summary of Atmospheric Ionizing AIR Research: SST-Present

NASA Technical Reports Server (NTRS)

Wilson, J. W.; Goldhagen, P.; Rafnsson, V.; deAngelis, G.; Friedberg, W.; Clem, J. M.

2003-01-01

The Supersonic Transport (SST) program, proposed in 1961, first raised concern for the exposure of pregnant occupants by solar energetic particles (SEP), and neutrons were suspected to have a main role in particle propagation deep into the atmosphere. An eight-year flight program confirmed the role of SEP as a significant hazard and of the neutrons as contributing over half of the galactic cosmic ray (GCR) exposures, with the largest contribution from neutrons above 10 MeV. The FAA Advisory Committee on the Radiobiological Aspects of the SST provided operational requirements. The more recent lowering of the radiation exposure limits by the International Commission on Radiological Protection with the classification of aircrew as radiation workers renewed interest in GCR background exposures at commercial flight altitudes and stimulated epidemiological studies in Europe, Japan, Canada and the USA. The proposed development of a High Speed Civil Transport (HSCT) required validation of the role of high-energy neutrons, and this resulted in ER-2 flights at solar minimum (June 1997) and studies on effects of aircraft materials on interior exposures. Recent evaluation of health outcomes of DOE nuclear workers resulted in legislation for health compensation in year 2000 and recent European aircrew epidemiological studies of health outcomes bring renewed interest in aircraft radiation exposures. As improved radiation models become available, it is imperative that a corresponding epidemiological program of US aircrew be implemented.

Overview of Atmospheric Ionizing Radiation (AIR) Research: SST - Present

NASA Technical Reports Server (NTRS)

Wilson, J. W.; Goldhagen, P.; Rafnsson, V.; Clem, J. M.; DeAngelis, G.; Friedberg, W.

2002-01-01

The Supersonic Transport (SST) program, proposed in 1961, first raised concern for the exposure of pregnant occupants by solar energetic particles (SEP), and neutrons were suspected to have a main role in particle propagation deep into the atmosphere. An eight-year flight program confirmed the role of SEP as a significant hazard and of the neutrons as contributing over half of the galactic cosmic ray (GCR) exposures, with the largest contribution from neutrons above 10 MeV. The FAA Advisory Committee on the Radiobiological Aspects of the SST provided operational requirements. The more recent (1990) lowering of recommended exposure limits by the International Commission on Radiological Protection with the classification of aircrew as "radiation workers" renewed interest in GCR background exposures at commercial flight altitudes and stimulated epidemiological studies in Europe, Japan, Canada and the USA. The proposed development of a High Speed Civil Transport (HSCT) required validation of the role of high-energy neutrons, and this resulted in ER-2 flights at solar minimum (June 1997) and studies on effects of aircraft materials on interior exposures. Recent evaluation of health outcomes of DOE nuclear workers resulted in legislation for health compensation in year 2000 and recent European aircrew epidemiological studies of health outcomes bring renewed interest in aircraft radiation exposures. As improved radiation models become available, it is imperative that a corresponding epidemiological program of US aircrew be implemented.

Overview of atmospheric ionizing radiation (AIR) research: SST-present.

PubMed

Wilson, J W; Goldhagen, P; Rafnsson, V; Clem, J M; De Angelis, G; Friedberg, W

2003-01-01

The Supersonic Transport (SST) program, proposed in 1961, first raised concern for the exposure of pregnant occupants by solar energetic particles (SEP), and neutrons were suspected to have a main role in particle propagation deep into the atmosphere. An eight-year flight program confirmed the role of SEP as a significant hazard and of the neutrons as contributing over half of the galactic cosmic ray exposures, with the largest contribution from neutrons above 10 MeV. The FAA Advisory Committee on the Radiobiological Aspects of the SST provided operational requirements. The more recent lowering of ICRP-recommended exposure limits (1990) with the classification of aircrew as "radiation workers" renewed interest in GCR background exposures at commercial flight altitudes and stimulated epidemiological studies in Europe, Japan, Canada and the USA. The proposed development of a High Speed Civil Transport (HSCT) required validation of the role of high-energy neutrons, and this resulted in ER-2 flights at solar minimum (June 1997) and studies on effects of aircraft materials on interior exposures. Recent evaluation of health outcomes of DOE nuclear workers resulted in legislation for health compensation in year 2000 and recent European aircrew epidemiological studies of health outcomes bring renewed interest in aircraft radiation exposures. As improved radiation models become available, it is imperative that a corresponding epidemiological program of US aircrew be implemented. Published by Elsevier Ltd on behalf of COSPAR.

Transport, Acceleration and Spatial Access of Solar Energetic Particles

NASA Astrophysics Data System (ADS)

Borovikov, D.; Sokolov, I.; Effenberger, F.; Jin, M.; Gombosi, T. I.

2017-12-01

Solar Energetic Particles (SEPs) are a major branch of space weather. Often driven by Coronal Mass Ejections (CMEs), SEPs have a very high destructive potential, which includes but is not limited to disrupting communication systems on Earth, inflicting harmful and potentially fatal radiation doses to crew members onboard spacecraft and, in extreme cases, to people aboard high altitude flights. However, currently the research community lacks efficient tools to predict such hazardous SEP events. Such a tool would serve as the first step towards improving humanity's preparedness for SEP events and ultimately its ability to mitigate their effects. The main goal of the presented research is to develop a computational tool that provides the said capabilities and meets the community's demand. Our model has the forecasting capability and can be the basis for operational system that will provide live information on the current potential threats posed by SEPs based on observations of the Sun. The tool comprises several numerical models, which are designed to simulate different physical aspects of SEPs. The background conditions in the interplanetary medium, in particular, the Coronal Mass Ejection driving the particle acceleration, play a defining role and are simulated with the state-of-the-art MHD solver, Block-Adaptive-Tree Solar-wind Roe-type Upwind Scheme (BATS-R-US). The newly developed particle code, Multiple-Field-Line-Advection Model for Particle Acceleration (M-FLAMPA), simulates the actual transport and acceleration of SEPs and is coupled to the MHD code. The special property of SEPs, the tendency to follow magnetic lines of force, is fully taken advantage of in the computational model, which substitutes a complicated 3-D model with a multitude of 1-D models. This approach significantly simplifies computations and improves the time performance of the overall model. Also, it plays an important role of mapping the affected region by connecting it with the origin of SEPs at the solar surface. Our model incorporates the effects of the near-Sun field line meandering that affects the perpendicular transport of SEPs and can explain the occurrence of large longitudinal spread observed even in the early phases of such events.

77 FR 58198 - Self-Regulatory Organizations; BATS Exchange, Inc.; Notice of Filing and Immediate Effectiveness...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-09-19

... Change Related to Fees Applicable to the Exchange's Competitive Liquidity Provider Program. September 13... Competitive Liquidity Providers (``CLPs'') to enhance liquidity on the Exchange in Exchange- listed securities (``Competitive Liquidity Provider Program'' or ``CLP Program'').\\6\\ The Exchange subsequently adopted financial...

Socioeconomic inequalities in all-cause mortality in the Czech Republic, Russia, Poland and Lithuania in the 2000s: findings from the HAPIEE Study.

PubMed

Vandenheede, Hadewijch; Vikhireva, Olga; Pikhart, Hynek; Kubinova, Ruzena; Malyutina, Sofia; Pajak, Andrzej; Tamosiunas, Abdonas; Peasey, Anne; Simonova, Galina; Topor-Madry, Roman; Marmot, Michael; Bobak, Martin

2014-04-01

Relatively large socioeconomic inequalities in health and mortality have been observed in Central and Eastern Europe (CEE) and the former Soviet Union (FSU). Yet comparative data are sparse and virtually all studies include only education. The aim of this study is to quantify and compare socioeconomic inequalities in all-cause mortality during the 2000s in urban population samples from four CEE/FSU countries, by three different measures of socioeconomic position (SEP) (education, difficulty buying food and household amenities), reflecting different aspects of SEP. Data from the prospective population-based HAPIEE (Health, Alcohol, and Psychosocial factors in Eastern Europe) study were used. The baseline survey (2002-2005) included 16 812 men and 19 180 women aged 45-69 years in Novosibirsk (Russia), Krakow (Poland), Kaunas (Lithuania) and seven Czech towns. Deaths in the cohorts were identified through mortality registers. Data were analysed by direct standardisation and Cox regression, quantifying absolute and relative SEP differences. Mortality inequalities by the three SEP indicators were observed in all samples. The magnitude of inequalities varied according to gender, country and SEP measure. As expected, given the high mortality rates in Russian men, largest absolute inequalities were found among Russian men (educational slope index of inequality was 19.4 per 1000 person-years). Largest relative inequalities were observed in Czech men and Lithuanian subjects. Disadvantage by all three SEP measures remained strongly associated with increased mortality after adjusting for the other SEP indicators. The results emphasise the importance of all SEP measures for understanding mortality inequalities in CEE/FSU.

Relevance of near-Earth magnetic field modeling in deriving SEP properties using ground-based data

NASA Astrophysics Data System (ADS)

Kanellakopoulos, Anastasios; Plainaki, Christina; Mavromichalaki, Helen; Laurenza, Monica; Gerontidou, Maria; Storini, Marisa; Andriopoulou, Maria

2014-05-01

Ground Level Enhancements (GLEs) are short-term increases observed in cosmic ray intensity records of ground-based particle detectors such as neutron monitors (NMs) or muon detectors; they are related to the arrival of solar relativistic particles in the terrestrial environment. Hence, GLE events are related to the most energetic class of solar energetic particle (SEP) events. In this work we investigate how the use of different magnetospheric field models can influence the derivation of the relativistic SEP properties when modeling GLE events. As a case study, we examine the event of 2012 May 17 (also known as GLE71), registered by ground-based NMs. We apply the Tsyganenko 89 and the Tsyganenko 96 models in order to calculate the trajectories of the arriving SEPs in the near-Earth environment. We show that the intersection of the SEP trajectories with the atmospheric layer at ~20 km from the Earth's surface (i.e., where the flux of the generated secondary particles is maximum), forms for each ground-based neutron monitor a specified viewing region that is dependent on the magnetospheric field configuration. Then, we apply the Neutron Monitor Based Anisotropic GLE Pure Power Law (NMBANGLE PPOLA) model (Plainaki et al. 2010, Solar Phys, 264, 239), in order to derive the spectral properties of the related SEP event and the spatial distributions of the SEP fluxes impacting the Earth's atmosphere. We examine the dependence of the results on the used magnetic field models and evaluate their range of validity. Finally we discuss information derived by modeling the SEP spectrum in the frame of particle acceleration scenarios.

Television viewing and other screen-based entertainment in relation to multiple socioeconomic status indicators and area deprivation: the Scottish Health Survey 2003.

PubMed

Stamatakis, E; Hillsdon, M; Mishra, G; Hamer, M; Marmot, M

2009-09-01

Sedentary behaviour (sitting) is detrimental to health, independently of participation in physical activity. Socioeconomic position (SEP) is known to relate strongly to physical activity participation but we know very little about how SEP relates to sedentary behaviour. This study aimed to assess the relationships between SEP, neighbourhood deprivation and an index of sedentary time. Cross-sectional study of a representative sample of 7940 Scottish adults who participated in the 2003 Scottish Health Survey, which collected information on SEP (household income, social class and education), neighbourhood deprivation (Scottish Index of Multiple Deprivation), television and other screen-based entertainment time, and physical activity. The three indicators of SEP and deprivation index were independently of each other associated with daily times of television and other screen-based entertainment, even after adjustment for occupational and leisure-time physical activity, health status, smoking, alcohol drinking, car ownership and body mass index: income p = 0.002; social class p<0.001; education p<0.001, deprivation p<0.001. Also, there was a strong cumulative effect of SEP (a composite scale where 0 = lowest, 9 = highest SEP position) with those in the lowest SEP spending an additional 109 minutes each day on screen-based entertainment compared to those in the highest socioeconomic position (p<0.001 for linear trend). Adverse socioeconomic position is associated with a cumulative increase in the time spent on screen-based entertainment. Reducing inequalities would be expected to reduce exposure to sedentary behaviours, such as excessive screen-based entertainment times, and therefore reduce the risk of chronic disease.

Do Solar Coronal Holes Affect the Properties of Solar Energetic Particle Events?

NASA Technical Reports Server (NTRS)

Kahler, S. W.; Arge, C. N.; Akiyama, S.; Gopalswamy, N.

2013-01-01

The intensities and timescales of gradual solar energetic particle (SEP) events at 1 AU may depend not only on the characteristics of shocks driven by coronal mass ejections (CMEs), but also on large-scale coronal and interplanetary structures. It has long been suspected that the presence of coronal holes (CHs) near the CMEs or near the 1-AU magnetic footpoints may be an important factor in SEP events. We used a group of 41 E (is) approx. 20 MeV SEP events with origins near the solar central meridian to search for such effects. First we investigated whether the presence of a CH directly between the sources of the CME and of the magnetic connection at 1 AU is an important factor. Then we searched for variations of the SEP events among different solar wind (SW) stream types: slow, fast, and transient. Finally, we considered the separations between CME sources and CH footpoint connections from 1 AU determined from four-day forecast maps based on Mount Wilson Observatory and the National Solar Observatory synoptic magnetic-field maps and the Wang-Sheeley-Arge model of SW propagation. The observed in-situ magnetic-field polarities and SW speeds at SEP event onsets tested the forecast accuracies employed to select the best SEP/CH connection events for that analysis. Within our limited sample and the three analytical treatments, we found no statistical evidence for an effect of CHs on SEP event peak intensities, onset times, or rise times. The only exception is a possible enhancement of SEP peak intensities in magnetic clouds.

Adolescent alcohol use and parental and adolescent socioeconomic position in six European cities.

PubMed

Bosque-Prous, Marina; Kuipers, Mirte A G; Espelt, Albert; Richter, Matthias; Rimpelä, Arja; Perelman, Julian; Federico, Bruno; Brugal, M Teresa; Lorant, Vincent; Kunst, Anton E

2017-08-08

Many risk behaviours in adolescence are socially patterned. However, it is unclear to what extent socioeconomic position (SEP) influences adolescent drinking in various parts of Europe. We examined how alcohol consumption is associated with parental SEP and adolescents' own SEP among students aged 14-17 years. Cross-sectional data were collected in the 2013 SILNE study. Participants were 8705 students aged 14-17 years from 6 European cities. The dependent variable was weekly binge drinking. Main independent variables were parental SEP (parental education level and family affluence) and adolescents' own SEP (student weekly income and academic achievement). Multilevel Poisson regression models with robust variance and random intercept were fitted to estimate the association between adolescent drinking and SEP. Prevalence of weekly binge drinking was 4.2% (95%CI = 3.8-4.6). Weekly binge drinking was not associated with parental education or family affluence. However, weekly binge drinking was less prevalent in adolescents with high academic achievement than those with low achievement (PR = 0.34; 95%CI = 0.14-0.87), and more prevalent in adolescents with >€50 weekly income compared to those with ≤€5/week (PR = 3.14; 95%CI = 2.23-4.42). These associations were found to vary according to country, but not according to gender or age group. Across the six European cities, adolescent drinking was associated with adolescents' own SEP, but not with parental SEP. Socio-economic inequalities in adolescent drinking seem to stem from adolescents' own situation rather than that of their family.

The Charged Particle Environment on the Surface of Mars induced by Solar Energetic Particles - Five Years of Measurements with the MSL/RAD instrument

NASA Astrophysics Data System (ADS)

Ehresmann, B.; Hassler, D.; Zeitlin, C.; Guo, J.; Lee, C. O.; Wimmer-Schweingruber, R. F.; Appel, J. K.; Boehm, E.; Boettcher, S. I.; Brinza, D. E.; Burmeister, S.; Lohf, H.; Martin-Garcia, C.; Matthiae, D.; Rafkin, S. C.; Reitz, G.

2017-12-01

NASA's Mars Science Laboratory (MSL) mission has now been operating in Gale crater on the surface of Mars for five years. On board MSL, the Radiation Assessment Detector (MSL/RAD) is measuring the Martian surface radiation environment, providing insights on its intensity and composition. This radiation field is mainly composed of primary Galactic Cosmic Rays (GCRs) and secondary particles created by the GCRs' interactions with the Martian atmosphere and soil. However, on shorter time scales the radiation environment can be dominated by contributions from Solar Energetic Particle (SEP) events. Due to the modulating effect of the Martian atmosphere shape and intensity of these SEP spectra will differ significantly between interplanetary space and the Martian surface. Understanding how SEP events influence the surface radiation field is crucial to assess associated health risks for potential human missions to Mars. Here, we present updated MSL/RAD results for charged particle fluxes measured on the surface during SEP activity from the five years of MSL operations on Mars. The presented results incorporate updated analysis techniques for the MSL/RAD data and yield the most robust particle spectra to date. Furthermore, we compare the MSL/RAD SEP-induced fluxes to measurements from other spacecraft in the inner heliosphere and, in particular, in Martian orbit. Analyzing changes of SEP intensities from interplanetary space to the Martian surface gives insight into the modulating effect of the Martian atmosphere, while comparing timing profiles of SEP events between Mars and different points in interplanetary space can increase our understanding of SEP propagation in the heliosphere.

Impact of socioeconomic position and distance on mental health care utilization: a nationwide Danish follow-up study.

PubMed

Packness, Aake; Waldorff, Frans Boch; Christensen, René dePont; Hastrup, Lene Halling; Simonsen, Erik; Vestergaard, Mogens; Halling, Anders

2017-11-01

To determine the impact of socioeconomic position (SEP) and distance to provider on outpatient mental health care utilization among incident users of antidepressants. A nationwide register-based cohort study of 50,374 person-years. Persons in low SEP were more likely to have outpatient psychiatrist contacts [odds ratio (OR) 1.25; confidence interval (CI) 1.17-1.34], but less likely to consult a co-payed psychologist (OR 0.49; CI 0.46-0.53) and to get mental health service from a GP (MHS-GP) (OR 0.81; CI 0.77-0.86) compared to persons in high SEP after adjusting for socio-demographics, comorbidity and car ownership. Furthermore, persons in low SEP who had contact to any of these therapists tended to have lower rates of visits compared to those in high SEP. When distance to services increased by 5 km, the rate of visits to outpatient psychiatrist tended to decrease by 5% in the lowest income group (IRR 0.95; CI 0.94-0.95) and 1% in the highest (IRR 0.99; CI 0.99-1.00). Likewise, contact to psychologists decreased by 11% in the lowest income group (IRR 0.89; CI 0.85-0.94), whereas rate of visits did not interact. Patients in low SEP have relatively lower utilization of mental health services even when services are free at delivery; co-payment and distance to provider aggravate the disparities in utilization between patients in high SEP and patients in low SEP.

Worldwide Report, Telecommunications Policy, Research, and Development

DTIC Science & Technology

1985-10-21

STATESMAN, 11 Sep 85) 20 All-India Radio To Gear Up External Services (M. Shamim ; Bombay THE TIMES OF INDIA, 9 Sep 85) 22 More Details on Indigenous...INDIA in English 9 Sep 85 p 9 [Article by M Shamim ] [Text] NEW DELHI, September 8. ’. THE government is studying I proposals to restructure

SEPEM: A tool for statistical modeling the solar energetic particle environment

NASA Astrophysics Data System (ADS)

Crosby, Norma; Heynderickx, Daniel; Jiggens, Piers; Aran, Angels; Sanahuja, Blai; Truscott, Pete; Lei, Fan; Jacobs, Carla; Poedts, Stefaan; Gabriel, Stephen; Sandberg, Ingmar; Glover, Alexi; Hilgers, Alain

2015-07-01

Solar energetic particle (SEP) events are a serious radiation hazard for spacecraft as well as a severe health risk to humans traveling in space. Indeed, accurate modeling of the SEP environment constitutes a priority requirement for astrophysics and solar system missions and for human exploration in space. The European Space Agency's Solar Energetic Particle Environment Modelling (SEPEM) application server is a World Wide Web interface to a complete set of cross-calibrated data ranging from 1973 to 2013 as well as new SEP engineering models and tools. Both statistical and physical modeling techniques have been included, in order to cover the environment not only at 1 AU but also in the inner heliosphere ranging from 0.2 AU to 1.6 AU using a newly developed physics-based shock-and-particle model to simulate particle flux profiles of gradual SEP events. With SEPEM, SEP peak flux and integrated fluence statistics can be studied, as well as durations of high SEP flux periods. Furthermore, effects tools are also included to allow calculation of single event upset rate and radiation doses for a variety of engineering scenarios.

The Selenylation Modification of Epimedium Polysaccharide and Isatis Root Polysaccharide and the Immune-enhancing Activity Comparison of Their Modifiers.

PubMed

Li, Xiuping; Hou, Ranran; Yue, Chanjuan; Liu, Jie; Gao, Zhenzhen; Chen, Jin; Lu, Yu; Wang, Deyun; Liu, Cui; Hu, Yuanliang

2016-05-01

Epimedium polysaccharide (EPS) and isatis root polysaccharide (IRPS) were extracted, purified, and selenizingly modified by nitric acid-sodium selenite method to obtain nine selenizing EPSs (sEPSs), sEPS1-sEPS9 and nine selenizing IRPSs (sIRPSs), sIRPS1-sIRPS9, respectively. Their effects on chicken peripheral lymphocyte proliferation in vitro were compared by MTT assay. The results showed that selenium polysaccharides at appropriate concentration could promote lymphocyte proliferation more significantly than unmodified polysaccharides, sEPS5 and sIRPS5 with stronger actions were picked out and injected into the chickens vaccinated with Newcastle disease vaccine in vivo tests. The peripheral lymphocyte proliferation and serum antibody titer were determined. The results showed that sEPS5 and sIRPS5 could elevate serum antibody titer and promote lymphocyte proliferation more significantly than unmodified polysaccharides, sEPS5 possessed the strongest efficacy. These results indicate that selenylation modification can significantly enhance the immune-enhancing activity of EPS and IRPS, and sEPS5 can be as a new-type immunopotentiator of chickens.

Solar Energetic Particle Events Observed on Mars with MSL/RAD

NASA Astrophysics Data System (ADS)

Ehresmann, B.; Hassler, D.; Zeitlin, C.; Guo, J.; Wimmer-Schweingruber, R. F.; Appel, J. K.; Boehm, E.; Boettcher, S. I.; Brinza, D. E.; Burmeister, S.; Lohf, H.; Martin-Garcia, C.; Rafkin, S. C.; Posner, A.; Reitz, G.

2016-12-01

The Mars Science Laboratory's Radiation Assessment Detector (MSL/RAD) has been conducting measurements of the ionizing radiation field on the Martian surface since August 2012. While this field is mainly dominated by Galactic Cosmic Rays (GCRs) and their interactions with the atoms in the atmosphere and soil, Solar Energetic Particle (SEP) events can contribute significantly to the radiation environment on short time scales and enhance and dominate, in particular, the Martian surface proton flux. Monitoring and understanding the effects of these SEP events on the radiation environment is of great importance to assess the associated health risks for potential, future manned missions to Mars. Furthermore, measurements of the proton spectra during such events aids in the validation of particle transport codes that are used to model the propagation of SEPs through the Martian atmosphere. Comparing the temporal evolution of the SEP events signals detected by MSL/RAD with measurements from other spacecraft can further yield insight into SEP propagation throughout the heliosphere. Here, we present and overview of measurements of the SEP events that have been directly detected on the Martian surface by the MSL/RAD instrument.

LIFECOURSE SOCIOECONOMIC POSITION AND 16 YEAR BODY MASS INDEX TRAJECTORIES : DIFFERENCES BY RACE AND SEX

PubMed Central

Insaf, Tabassum Z; Shaw, Benjamin A; Yucel, Recai M; Chasan-Taber, Lisa; Strogatz, David S

2014-01-01

Objective To evaluate the association between lifecourse socioeconomic position (SEP) and changes in body mass index (BMI), and assess disparities in these associations across racial/ethnic groups. Methods With longitudinal data from 4 waves of the Americans Changing Lives Study (1986–2002), we employed mixed-effects modeling to estimate BMI trajectories for 1,174 Blacks and 2,323 White adults. We also estimated associations between these trajectories and lifecourse SEP variables, including father’s education, perceived childhood SEP, own education, income, wealth, and financial security. Results Blacks had higher baseline BMI’s, and steeper increases in BMI, compared to Whites. Childhood SEP, as measured by high father’s education, was associated with lower baseline BMI among Whites. High education was associated with a lower baseline BMI within both race and sex categories. Income had contrasting effects among men and women. Higher income, was associated with higher BMI only among males Associations between indicators of SEP and BMI trajectories were only found for Whites. Conclusions Our study demonstrates that lifecourse SEP may influence adult BMI differently within different racial and sex groups. PMID:24967954

NASA's 2004 In-Space Propulsion Refocus Studies for New Frontiers Class Missions

NASA Technical Reports Server (NTRS)

Witzberger, Kevin E.; Manzella, David; Oh, David; Cupples, Mike

2006-01-01

The New Frontiers (NF) program is designed to provide opportunities to fulfill the science objectives for top priority, medium class missions identified in the Decadal Solar System Exploration Survey. This paper assesses the applicability of the In-Space Propulsion s (ISP) Solar Electric Propulsion (SEP) technologies for representative NF class missions that include a Jupiter Polar Orbiter with Probes (JPOP), Comet Surface Sample Return (CSSR), and two different Titan missions. The SEP technologies evaluated include the 7-kW, 4,100-second NASA's Evolutionary Xenon Thruster (NEXT), the 3-kW, 2,700-second Hall thruster, and two different NASA Solar Electric Propulsion Technology Readiness (NSTAR) thrusters that are variants of the Deep Space 1 (DS1) thruster. One type of NSTAR, a 2.6-kW, 3,100-second thruster, will be the primary propulsion system for the DAWN mission that is scheduled to launch in 2006; the other is an "enhanced", higher power variant (3.8-kW, 4,100-second) and is so-called because it uses NEXT system components such as the NEXT power processing unit (PPU). The results show that SEP is applicable for the CSSR mission and a Titan Lander mission. In addition, NEXT has improved its applicability for these types of missions by modifying its thruster performance relative to its performance at the beginning of this study.

Application of sequential extraction analysis to Pb(II) recovery by zerovalent iron-based particles.

PubMed

Zhu, Neng-Min; Xu, Yan-Sheng; Dai, Lichun; Zhang, Yun-Fei; Hu, Guo-Quan

2018-06-05

Zerovalent iron (ZVI) is an environmental-friendly reactive reagent for recovering heavy metals. However, the detailed recovery mechanism remains unclear due to a lack of quantitative analysis of recovery products. Herein, microscale ZVI, nanoscale ZVI and Ni/Fe nanoparticles were used to recover Pb(II) in aqueous solution and a sequential extraction procedure (SEP) was applied to determine the formed lead species quantitatively. At high initial Pb(II) concentration (500 mg L -1 ), more than 99.5% of Pb(II) was immobilized by Ni/Fe and n-ZVI, whereas m-ZVI caused inferior recovery efficiency (<25%). XRD and XPS results revealed that Pb(II) was reduced to Pb 0 prior to the formation of metal hydroxides as the external shell of ZVI. SEP results showed that the fraction bound to carbonates (PbO), fraction bound to iron oxides and exchangeable fraction were the main lead species conducted by Ni/Fe, n-ZVI and m-ZVI, respectively. Consequently, (co-)precipitation and specific adsorption dominated Pb(II) recovery by Ni/Fe and n-ZVI, whereas m-ZVI conducted Pb(II) recovery mainly via weak adsorption. The reactivity of ZVI toward Pb(II) followed the increasing order of m-ZVI < n-ZVI ≤ Ni/Fe. The detailed mechanisms of Pb(II) recovery conducted by different ZVI were proposed. Copyright © 2018 Elsevier B.V. All rights reserved.

Racial and ethnic health disparities: evidence of discrimination's effects across the SEP spectrum.

PubMed

D'Anna, Laura Hoyt; Ponce, Ninez A; Siegel, Judith M

2010-04-01

Perceived discrimination is a psychosocial stressor that plays a role in explaining racial/ethnic disparities in self-reported physical and mental health. The purpose of this paper is: (1) to investigate the association between perceived discrimination in receiving healthcare and racial/ethnic disparities in self-rated health status, physical, and emotional functional limitations among a diverse sample of California adults; (2) to assess whether discrimination effects vary by racial/ethnic group and gender; and (3) to evaluate how the effects of discrimination on health are manifest across the socioeconomic position (SEP) spectrum. Data were drawn from the 2001 California Health Interview Survey adult file (n=55,428). The analytic approach employed multivariate linear and logistic regressions. Discrimination is qualitatively identified into two types: (1) discrimination due to race/ethnicity, language, or accent, and (2) other discrimination. Findings show that both types of discrimination negatively influenced self-rated health, and were associated with a two to three-fold odds of limitations in physical and emotional health. Further, these effects varied by racial/ethnic group and gender, and the effects were mixed. Most notably, for emotional health, racial/ethnic discrimination penalized Latinas more than non-Latina Whites, but for physical health, other discrimination was less detrimental to Latinas than it was to non-Latina Whites. At higher levels of SEP, the effects of racial/ethnic discrimination on self-rated health and other discriminations' effects on physical health were attenuated. Higher SEP may serve as an important mitigator, particularly when comparing the medium to the low SEP categories. It is also possible that SEP effects cannot be extracted from the relationships of interest in that SEP is an expression of social discrimination. In fact, negative health effects associated with discrimination are evident across the SEP spectrum. This study highlights the complexity of the relationships between discrimination and racial/ethnic identity, gender, and SEP.

BOREAS TE-5 Diurnal CO2 Canopy Profile Data

NASA Technical Reports Server (NTRS)

Hall, Forrest G. (Editor); Curd, Shelaine (Editor); Ehleriinger, Jim; Brooks, J. Renee; Flanagan, Larry

2000-01-01

The BOREAS TE-5 team collected several data sets to investigate the vegetation-atmosphere CO2 and H2O exchange processes. These data were collected to provide detailed information within the canopy during times when TE-05 sampled canopy CO2 for carbon and oxygen isotope analysis. These measurements were made in both the NSA and SSA at the OJP, OBS, UBS, and OA sites from 25-May1994 to 08-Sep1994. CO2 profile data were not collected at SSA-OA during the first IFC. The data are available in tabular ASCII files. The data files are available on a CD-ROM (see document number 20010000884), or from the Oak Ridge National Laboratory (ORNL) Distributed Activity Archive Center (DAAC).

Analysis of Fratricide in United States Naval Surface and Submarine Forces in the Second World War.

DTIC Science & Technology

1999-09-01

22 3. Poisson Process Applicability 29 4 . Submarines ....31 IV. THE NATURE OF NAVAL FRATRICIDE 35 A. CAUSES 35 1. Misidentification 35 2...expect to see a result similar to Figure 2b: the 7 For details of the following discussion, see Devore, Chapter 3, and Ross, Chapter 5. 29 variance of...43 YC BRANT ARS 32 28 Sep 43 Y PATTERSON DD392 29 Sep 43 YN MCCALLA DD488 29 Sep 43 YN PT126 30 Sep 43 Y O’BANNON DD450 06 Oct 43 YC DORADO SS

Software-Engineering Process Simulation (SEPS) model

NASA Technical Reports Server (NTRS)

Lin, C. Y.; Abdel-Hamid, T.; Sherif, J. S.

1992-01-01

The Software Engineering Process Simulation (SEPS) model is described which was developed at JPL. SEPS is a dynamic simulation model of the software project development process. It uses the feedback principles of system dynamics to simulate the dynamic interactions among various software life cycle development activities and management decision making processes. The model is designed to be a planning tool to examine tradeoffs of cost, schedule, and functionality, and to test the implications of different managerial policies on a project's outcome. Furthermore, SEPS will enable software managers to gain a better understanding of the dynamics of software project development and perform postmodern assessments.

78 FR 48520 - Self-Regulatory Organizations; New York Stock Exchange LLC; Notice of Filing and Immediate...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-08

... Proposed Rule Change Extending the Pilot Period for the Exchange's Retail Liquidity Program for an... The Exchange proposes to extend the pilot period for the Exchange's Retail Liquidity Program (the ``Retail Liquidity Program'' or the ``Program''), which is currently scheduled to expire on July 31, 2013...

Europe/Latin America Report, Science and Technology

DTIC Science & Technology

1997-01-16

Space Accord 3 AUTOMOBILE INDUSTRY Volvo Chief Attacks Japanese Car Manufacturers’ Tactics in Sweden (SVENSKA DAGBLADET, 21 Nov 86) 4...Great Britain (BIOTEC, Apr 86) 10 EEC’s 1982-86 Biotechnology Programs (BIOTEC, Apr 86) 11 - a Industry , Universities Meet in Italy on...Epitaxy Devices (S. Dumontet; ELECTRONIQUE ACTUALITES, 19 Sep 86) 23 Briefs French Indium Phosphide Production 25 SCIENTIFIC AND INDUSTRIAL POLICY

The Leadership Improvement Modules of the Precommissioning Leadership Assessment Program

DTIC Science & Technology

1986-02-01

Institute - Patricia Knight Davis Development Dimensions International DTIC ELECTE SEP 0 3W U5 D Leadership and Management Technical Area Manpower and... Management skills Development Management training Interpersonal skills Remedial training Leadership skills Role playing IL ASISRACT (Cl -ewi rebb emem II by...Burke Army Research Institute Patricia Knight Davis Development Dimensions International Leadership and Management Technical Area William W. Haythorn

INHALATIONAL EXPOSURE TO CARBONYL SULFIDE (COS) PRODUCES BRAIN LESIONS AND ALTERED BRAINSTEM AUDITORY (BAER) AND SOMATOSENSORY (SEP) EVOKED POTENTIALS IN FISHCER 344N RATS.

EPA Science Inventory

Because of the amount of carbonyl sulfide (COS) emissions and the lack of toxicological data, COS was listed in the Clean Air Act of 1990 as a Hazardous Air Pollutant. In 1999 COS was nominated by the US EPA to the National Toxicology Program for additional toxicological investig...

Workload Intensity, The Nursing Practice Environment, and Adverse Events

DTIC Science & Technology

2014-01-05

February). Are nursing outcome databases sensitive to outcome changes overtime ?, Southern Nursing Research Society 26th Annual Conference, New...FINAL 3. DATES COVERED (From - To) 1 SEP 2010- 31 AUG 2014 4. TITLE AND SUBTITLE Workload Intensity, the Nursing Practice Environment, and...10. SPONSOR/MONITOR’S ACRONYM(S) TriService Nursing Research TSNRP Program, 4301 Jones Bridge RD Bethesda, MD 20814 11. SPONSOR/MONITOR’S

Department of Defense Systems Engineering FY 2012 Annual Report

DTIC Science & Technology

2013-03-01

by the Utility Helicopter PMO, is utilizing the latest Defense Acquisition Guidelines and previously approved PEO AVN SEP examples to develop all...efforts. As a whole, all of PEO AVN Program Management Offices understand the importance of systems engineering. They stress the continued use of...established SE guidelines, practices and procedures throughout our acquisition processes. PEO AVN , working with the AMRDEC SE Division, has

Setup Instructions for the Applied Anomaly Detection Tool (AADT) Web Server

DTIC Science & Technology

2016-09-01

ARL-TR-7798 ● SEP 2016 US Army Research Laboratory Setup Instructions for the Applied Anomaly Detection Tool (AADT) Web Server...for the Applied Anomaly Detection Tool (AADT) Web Server by Christian D Schlesiger Computational and Information Sciences Directorate, ARL...SUBTITLE Setup Instructions for the Applied Anomaly Detection Tool (AADT) Web Server 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT

Plasma Physics of the Subauroral Space Weather

DTIC Science & Technology

2016-03-20

AFRL-RV-PS- AFRL-RV-PS- TR-2016-0068 TR-2016-0068 PLASMA PHYSICS OF THE SUBAURORAL SPACE WEATHER Evgeny V. Mishin, et al. 20 March 2016 Final...Oct 2013 to 30 Sep 2015 4. TITLE AND SUBTITLE Plasma Physics of the Subauroral Space Weather 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM...5 4.3. Physics -based hybrid model with finite Larmor radius effects

Field-Programmable Gate Array (FPGA) Emulation for Computer Architecture

DTIC Science & Technology

2009-08-01

Execution with Versatile, Microarchitecture-Independent Snapshots, PhD thesis, MIT, Sep 2006. [10] Bienia, Christian, Kumar , Sanjeev, Singh , Jaswinder Pal...2] Pixie: MIPS Computer Systems, Inc. Assembly Language Programmer’s Guide, 1986. [3] Agarwal, Anant , Bianchini, Ricardo, Chaiken, David, David...pp. 68–79. [49] Woo, Steven Cameron, Ohara, Moriyoshi, Torrie, Evan, Singh , Jaswinder Pal, and Gupta, Anoop, “The SPLASH-2 programs

Speech Intelligibility of Aircrew Mask Communication Configurations in High-Noise Environments

DTIC Science & Technology

2017-09-28

ARL-TR-8168 ● Sep 2017 US Army Research Laboratory Speech Intelligibility of Aircrew Mask Communication Configurations in High ...Laboratory Speech Intelligibility of Aircrew Mask Communication Configurations in High -Noise Environments by Kimberly A Pollard and Lamar Garrett...in High - Noise Environments 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) Kimberly A Pollard and Lamar

Is there a bone-nail specific entry point? Automated fit quantification of tibial nail designs during the insertion for six different nail entry points.

PubMed

Amarathunga, J P; Schuetz, M A; Yarlagadda, K V D; Schmutz, B

2015-04-01

Intramedullary nailing is the standard fixation method for displaced diaphyseal fractures of tibia. Selection of the correct nail insertion point is important for axial alignment of bone fragments and to avoid iatrogenic fractures. However, the standard entry point (SEP) may not always optimise the bone-nail fit due to geometric variations of bones. This study aimed to investigate the optimal entry for a given bone-nail pair using the fit quantification software tool previously developed by the authors. The misfit was quantified for 20 bones with two nail designs (ETN and ETN-Proximal Bend) related to the SEP and 5 entry points which were 5 mm and 10 mm away from the SEP. The SEP was the optimal entry point for 50% of the bones used. For the remaining bones, the optimal entry point was located 5 mm away from the SEP, which improved the overall fit by 40% on average. However, entry points 10 mm away from the SEP doubled the misfit. The optimised bone-nail fit can be achieved through the SEP and within the range of a 5 mm radius, except posteriorly. The study results suggest that the optimal entry point should be selected by considering the fit during insertion and not only at the final position. Copyright © 2015 IPEM. Published by Elsevier Ltd. All rights reserved.

Proteome Analysis and Serological Characterization of Surface-Exposed Proteins of Rickettsia heilongjiangensis

PubMed Central

Qi, Yong; Xiong, Xiaolu; Wang, Xile; Duan, Changsong; Jia, Yinjun; Jiao, Jun; Gong, Wenping; Wen, Bohai

2013-01-01

Background Rickettsia heilongjiangensis, the agent of Far-Eastern spotted fever (FESF), is an obligate intracellular bacterium. The surface-exposed proteins (SEPs) of rickettsiae are involved in rickettsial adherence to and invasion of host cells, intracellular bacterial growth, and/or interaction with immune cells. They are also potential molecular candidates for the development of diagnostic reagents and vaccines against rickettsiosis. Methods R. heilongjiangensis SEPs were identified by biotin-streptavidin affinity purification and 2D electrophoreses coupled with ESI-MS/MS. Recombinant SEPs were probed with various sera to analyze their serological characteristics using a protein microarray and an enzyme-linked immune sorbent assay (ELISA). Results Twenty-five SEPs were identified, most of which were predicted to reside on the surface of R. heilongjiangensis cells. Bioinformatics analysis suggests that these proteins could be involved in bacterial pathogenesis. Eleven of the 25 SEPs were recognized as major seroreactive antigens by sera from R. heilongjiangensis-infected mice and FESF patients. Among the major seroreactive SEPs, microarray assays and/or ELISAs revealed that GroEL, OmpA-2, OmpB-3, PrsA, RplY, RpsB, SurA and YbgF had modest sensitivity and specificity for recognizing R. heilongjiangensis infection and/or spotted fever. Conclusions Many of the SEPs identified herein have potentially important roles in R. heilongjiangensis pathogenicity. Some of them have potential as serodiagnostic antigens or as subunit vaccine antigens against the disease. PMID:23894656

Can Social Cognitive Theory Constructs Explain Socio-Economic Variations in Adolescent Eating Behaviours? A Mediation Analysis

ERIC Educational Resources Information Center

Ball, K.; MacFarlane, A.; Crawford, D.; Savige, G.; Andrianopoulos, N.; Worsley, A.

2009-01-01

Adolescents of low socio-economic position (SEP) are less likely than those of higher SEP to consume diets in line with current dietary recommendations. The reasons for these SEP variations remain poorly understood. We investigated the mechanisms underlying socio-economic variations in adolescents' eating behaviours using a theoretically derived…

29 CFR 2520.104-49 - Alternative method of compliance for certain simplified employee pensions.

Code of Federal Regulations, 2011 CFR

2011-07-01

... establishes or maintains the SEP selects, recommends or influences its employees to choose the IRAs into which... establishes or maintains the SEP selects, recommends or substantially influences its employees to choose the... that participant's IRA(s). (6) In the case of a SEP that provides for integration with Social Security...

The importance of age, sex and place in understanding socioeconomic inequalities in allostatic load: Evidence from the Scottish Health Survey (2008-2011).

PubMed

Robertson, Tony; Watts, Eleanor

2016-02-09

Given the broad spectrum of health and wellbeing outcomes that are patterned by socioeconomic position (SEP), it has been suggested that there may be common biological pathways linking SEP and health. Allostatic load is one such pathway, which aims to measure cumulative burden/dysregulation across multiple physiological systems. This study aimed to determine the contextual and demographic factors (age, sex and place) that may be important in better understanding the links between lower SEP and higher allostatic load. Data were from a nationally representative sample of adults (18+): the Scottish Health Survey (2008-2011). Higher SEP ('1') was defined as having 'Higher'-level, secondary school qualifications versus having lower level or no qualifications ('0'). For allostatic load, a range of 10 biomarkers across the cardiovascular, metabolic and immune systems were used. Respondents were scored "1" for each biomarker that fell into the highest quartile of risk. Linear regressions were run in STATA, including SEP, age (continuous and as a 7-category variable), sex (male/female), urbanity (a 5-category variable ranging from primary cities to remote rural areas) and geographical location (based on 10 area-level healthboards). Interactions between SEP and each predictor, as well as stratified analyses, were tested. Lower SEP was associated with higher allostatic load even after adjusting for age, sex and place (b = -0.631, 95 % CI -0.795, -0.389, p < 0.001). There was no significant effect moderation between SEP and age, sex or place. Stratified analysis did show that the inequality identified in the baseline models widened with age, becoming significant at ages 35-44, before narrowing at older ages (75+). There was no difference by sex, but more mixed findings with regards place (urbanity or geographical location), with a mix of significant and non-significant results by SEP that did not appear to follow any pattern. Inequalities in allostatic load by educational attainment, as a measure of SEP, are consistent with age, sex and place. However, these stratified analyses showed that these inequalities did widen with age, before narrowing in later life, matching the patterns seen with other objective and subjective health measures. However, effect moderation analysis did not support evidence of a statistically significant interaction between age and SEP. Context remains an important feature in understanding and potentially addressing inequalities, although may be less of an issue in terms of physiological burden.

Identification of Novel Surface-Exposed Proteins of Rickettsia rickettsii by Affinity Purification and Proteomics

PubMed Central

Gong, Wenping; Xiong, Xiaolu; Qi, Yong; Jiao, Jun; Duan, Changsong; Wen, Bohai

2014-01-01

Rickettsia rickettsii, the causative agent of Rocky Mountain spotted fever, is the most pathogenic member among Rickettsia spp. Surface-exposed proteins (SEPs) of R. rickettsii may play important roles in its pathogenesis or immunity. In this study, R. rickettsii organisms were surface-labeled with sulfo-NHS-SS-biotin and the labeled proteins were affinity-purified with streptavidin. The isolated proteins were separated by two-dimensional electrophoresis, and 10 proteins were identified among 23 protein spots by electrospray ionization tandem mass spectrometry. Five (OmpA, OmpB, GroEL, GroES, and a DNA-binding protein) of the 10 proteins were previously characterized as surface proteins of R. rickettsii. Another 5 proteins (Adr1, Adr2, OmpW, Porin_4, and TolC) were first recognized as SEPs of R. rickettsii herein. The genes encoding the 5 novel SEPs were expressed in Escherichia coli cells, resulting in 5 recombinant SEPs (rSEPs), which were used to immunize mice. After challenge with viable R. rickettsii cells, the rickettsial load in the spleen, liver, or lung of mice immunized with rAdr2 and in the lungs of mice immunized with other rSEPs excluding rTolC was significantly lower than in mice that were mock-immunized with PBS. The in vitro neutralization test revealed that sera from mice immunized with rAdr1, rAdr2, or rOmpW reduced R. rickettsii adherence to and invasion of vascular endothelial cells. The immuno-electron microscopic assay clearly showed that the novel SEPs were located in the outer and/or inner membrane of R. rickettsii. Altogether, the 5 novel SEPs identified herein might be involved in the interaction of R. rickettsii with vascular endothelial cells, and all of them except TolC were protective antigens. PMID:24950252

Type III-L Solar Radio Bursts and Solar Energetic Particle Events

NASA Astrophysics Data System (ADS)

Duffin, R. T.; White, S. M.; Ray, P. S.; Kaiser, M. L.

2015-09-01

A radio-selected sample of fast drift radio bursts with complex structure occurring after the impulsive phase of the associated flare (“Type III-L bursts”) is identified by inspection of radio dynamic spectra from 1 to 180 MHz for over 300 large flares in 2001. An operational definition that takes into account previous work on these radio bursts starting from samples of solar energetic particle (SEP) events is applied to the data, and 66 Type III-L bursts are found in the sample. In order to determine whether the presence of these radio bursts can be used to predict the occurrence of SEP events, we also develop a catalog of all SEP proton events in 2001 using data from the ERNE detector on the SOHO satellite. 68 SEP events are found, for 48 of which we can identify a solar source and hence look for associated Type III-L emission. We confirm previous work that found that most (76% in our sample) of the solar sources of SEP events exhibit radio emission of this type. However, the correlation in the opposite direction is not as strong: starting from a radio-selected sample of Type III-L events, around 64% of the bursts that occur at longitudes magnetically well-connected to the Earth, and hence favorable for detection of SEPs, are associated with SEP events. The degree of association increases when the events have durations over 10 minutes at 1 MHz, but in general Type III-L bursts do not perform any better than Type II bursts in our sample as predictors of SEP events. A comparison of Type III-L timing with the arrival of near-relativistic electrons at the ACE spacecraft is not inconsistent with a common source for the accelerated electrons in both phenomena.

Inhibitory Mechanisms in Primary Somatosensory Cortex Mediate the Effects of Peripheral Electrical Stimulation on Tactile Spatial Discrimination.

PubMed

Saito, Kei; Otsuru, Naofumi; Inukai, Yasuto; Kojima, Sho; Miyaguchi, Shota; Tsuiki, Shota; Sasaki, Ryoki; Onishi, Hideaki

2018-06-01

Selective afferent activation can be used to improve somatosensory function, possibly by altering cortical inhibitory circuit activity. Peripheral electrical stimulation (PES) is widely used to induce selective afferent activation, and its effect may depend on PES intensity. Therefore, we investigated the effects of high- and low-intensity PES applied to the right index finger on tactile discrimination performance and cortical sensory-evoked potential paired-pulse depression (SEP-PPD) in 25 neurologically healthy subjects. In Experiment 1, a grating orientation task (GOT) was performed before and immediately after local high- and low-intensity PES (both delivered as 1-s, 20-Hz trains of 0.2-ms electrical pulses at 5-s intervals). In Experiment 2, PPD of SEP components N20/P25_SEP-PPD and N20_SEP-PPD, respectively, were assessed before and immediately after high- and low-intensity PES. Improved GOT discrimination performance after high-intensity PES (reduced discrimination threshold) was associated with lower baseline performance (higher baseline discrimination threshold). Subjects were classified into low and high (baseline) GOT performance groups. Improved GOT discrimination performance in the low GOT performance group was significantly associated with a greater N20_SEP-PPD decrease (weaker PPD). Subjects were also classified into GOT improvement and GOT decrement groups. High-intensity PES decreased N20_SEP-PPD in the GOT improvement group but increased N20_SEP-PPD in the GOT decrement group. Furthermore, a greater decrease in GOT discrimination threshold was significantly associated with a greater N20_SEP-PPD decrease in the GOT improvement group. These results suggest that high-intensity PES can improve sensory perception in subjects with low baseline function by modulating cortical inhibitory circuits in primary somatosensory cortex. Copyright © 2018 The Author(s). Published by Elsevier Ltd.. All rights reserved.

Social inequalities in young children's sports participation and outdoor play.

PubMed

Wijtzes, Anne I; Jansen, Wilma; Bouthoorn, Selma H; Pot, Niek; Hofman, Albert; Jaddoe, Vincent W V; Raat, Hein

2014-12-16

Research on social inequalities in sports participation and unstructured physical activity among young children is scarce. This study aimed to assess the associations of family socioeconomic position (SEP) and ethnic background with children's sports participation and outdoor play. We analyzed data from 4726 ethnically diverse 6-year-old children participating in the Generation R Study. Variables were assessed by parent-reported questionnaires when the child was 6 years old. Low level of outdoor play was defined as outdoor play <1 hour per day. Series of multiple logistic regression analyses were performed to assess associations of family SEP and ethnic background with children's sports participation and outdoor play. Socioeconomic inequalities in children's sports participation were found when using maternal educational level (p < 0.05), paternal educational level (p < 0.05), maternal employment status (p < 0.05), and household income (p < 0.05) as family SEP indicator (less sports participation among low SEP children). Socioeconomic inequalities in children's outdoor play were found when using household income only (p < 0.05) (more often outdoor play <1 hour per day among children from low income household). All ethnic minority children were significantly more likely to not to participate in sports and play outdoor <1 hour per day compared with native Dutch children. Adjustment for family SEP attenuated associations considerably, especially with respect to sports participation. Low SEP children and ethnic minority children are more likely not to participate in sports and more likely to display low levels of outdoor play compared with high SEP children and native Dutch children, respectively. In order to design effective interventions, further research, including qualitative studies, is needed to explore more in detail the pathways relating family SEP and ethnic background to children's sports participation and outdoor play.

Socioeconomic position across life and body composition in early old age: findings from a British birth cohort study

PubMed Central

Bann, David; Cooper, Rachel; Wills, Andrew K; Adams, Judith; Kuh, Diana

2014-01-01

Background Previous studies have reported associations between lower lifetime socioeconomic position (SEP) and higher body mass index in adulthood, but few have examined associations with direct measures of fat and lean mass which are likely to have independent roles in health and physical functioning. Methods We examined associations of SEP across life with dual-energy X-ray absorptiometry measures of fat and lean mass at 60–64 years using data from a total of 1558 men and women participating in the Medical Research Council (MRC) National Survey of Health and Development. We also examined whether associations of childhood SEP with fat and lean mass were explained by preadulthood weight gain (birth weight, 0–7 and 7–20 years) and adult SEP. Results Lower SEP across life was associated with higher fat mass and higher android to gynoid fat mass ratio. For example, the mean difference in fat mass index comparing the lowest with the highest paternal occupational class at 4 years (slope index of inequality) was 1.04 kg/m1.2 in men (95% CI 0.09 to 1.99) and 2.61 in women (1.34 to 3.89), equivalent to a 8.6% and 16.1% difference, respectively. After adjustment for fat mass, lower SEP across life was associated with lower lean mass in women, while only contemporaneous household income was associated in men. Associations between childhood SEP and outcomes were partly explained by preadulthood weight gain and adult SEP. Conclusions This study identified lifetime socioeconomic patterning of fat and lean mass in early old age. This is likely to have important implications and may partly explain socioeconomic inequalities in health and physical functioning. PMID:24567442

Neurophysiological prediction of neurological good and poor outcome in post-anoxic coma.

PubMed

Grippo, A; Carrai, R; Scarpino, M; Spalletti, M; Lanzo, G; Cossu, C; Peris, A; Valente, S; Amantini, A

2017-06-01

Investigation of the utility of association between electroencephalogram (EEG) and somatosensory-evoked potentials (SEPs) for the prediction of neurological outcome in comatose patients resuscitated after cardiac arrest (CA) treated with therapeutic hypothermia, according to different recording times after CA. Glasgow Coma Scale, EEG and SEPs performed at 12, 24 and 48-72 h after CA were assessed in 200 patients. Outcome was evaluated by Cerebral Performance Category 6 months after CA. Within 12 h after CA, grade 1 EEG predicted good outcome and bilaterally absent (BA) SEPs predicted poor outcome. Because grade 1 EEG and BA-SEPs were never found in the same patient, the recording of both EEG and SEPs allows us to correctly prognosticate a greater number of patients with respect to the use of a single test within 12 h after CA. At 48-72 h after CA, both grade 2 EEG and BA-SEPs predicted poor outcome with FPR=0.0%. When these neurophysiological patterns are both present in the same patient, they confirm and strengthen their prognostic value, but because they also occurred independently in eight patients, poor outcome is predictable in a greater number of patients. The combination of EEG/SEP findings allows prediction of good and poor outcome (within 12 h after CA) and of poor outcome (after 48-72 h). Recording of EEG and SEPs in the same patients allows always an increase in the number of cases correctly classified, and an increase of the reliability of prognostication in a single patient due to concordance of patterns. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Human Mars Mission: SEP Architecture Crew Taxi Propulsion Stage Study and Design and Technology for Reaction and Control System. Part 1

NASA Technical Reports Server (NTRS)

Young, Archie

1999-01-01

The Mars exploration is a candidate pathway to expand human presence and useful activities in the solar system. There are several propulsion system options being considered to place the Mars payload on its inter-planetary transfer trajectory. One propulsion option is the use of Solar Electric Propulsion (SEP) to spiral out with the Mars payload from an initial Low Earth Orbit (LEO) to an elliptical High Earth Orbit (HEO). This report, presented in annotated facing page format, describes the work completed on the design of a crew taxi propulsion stage used in conjunction with the SEP. Transportation system/mission analysis topics covered in this report include sub-system analysis, trajectory profile description, mass performance and crew taxi stage sizing, stage configuration, stage cost, and Trans-Mars Injection (TMI) launch window. The high efficiency of SEP is used to provide the major part of the TMI propulsion maneuver. Orbital energy is continuously added over a period of approximately twelve months. The SEP and Mars payload follow a spiral trajectory from an initial LEO to a final elliptical HEO. A small chemical stage is then used to provide the final part of the TMI. The now unloaded SEP returns to LEO to repeat another spiral trajectory with payload to HEO. The spiral phase of the SEP's trajectory takes several months to reach HEO, thus significantly increasing the exposure time of the crew to zero-gravity. In order to minimize the long zero-gravity effects, a high thrust chemical stage delivers the crew to the SEP's HEO. The crew rendezvous with the Mars payload in HEO. After a checkout period the Mars payload with the crew is injected onto a Trans-Mars Trajectory by a small chemical stage.

Human Mars Mission: SEP Architecture, Crew Taxi Propulsion Stage Study and Design and Technology for Reaction and Control System. Pt. 1

NASA Technical Reports Server (NTRS)

Young, Archie

1999-01-01

The Mars exploration is a candidate pathway to expand human presence and useful activities in the solar system. There are several propulsion system options being considered to place the Mars payload on its interplanetary transfer trajectory. One propulsion option is the use of Solar Electric Propulsion (SEP) to spiral out with the Mars payload from an initial Low Earth Orbit (LEO) to an elliptical High Earth Orbit (HEO). This report, presented in annotated facing page format, describes the work completed on the design of a crew taxi propulsion stage used in conjunction with the SEP. Transportation system/mission analysis topics covered in this report include sub-system analysis, trajectory profile description, mass performance and crew taxi stage sizing, stage configuration, stage cost, and Trans-Mars Injection (TMI) launch window. The high efficiency of SEP is used to provide the major part of the TMI propulsion maneuver. Orbital energy is continuously added over a period of approximately twelve months. The SEP and Mars payload follow a spiral trajectory from an initial LEO to a final elliptical HEO. A small chemical stage is then used to provide the final part of the TMI. The now unloaded SEP returns to LEO to repeat another spiral trajectory with payload to HEO. The spiral phase of the SEP's trajectory takes several months to reach HEO, thus significantly increasing the exposure time of the crew to zero-gravity. In order to minimize the long zero-gravity effects, a high thrust chemical stage delivers the crew to the SEP's HEO. The crew rendezvous with the Mars payload in HEO. After a checkout period the Mars payload with the crew is injected onto a Trans-Mars Trajectory by a small chemical stage.

Connecting Shock Parameters to the Radiation Hazard from Energetic Particles

NASA Technical Reports Server (NTRS)

Berdichevsky, Daniel B.; Reames, Donald V.; Lepping, Ronald P.; Schwenn, Rainer W.

2004-01-01

We use data from Helios, IMP-8, and other spacecraft (e.g. ISEE) to systematically investigate solar energetic particle (SEP) events from different longitudes and distances in the heliosphere. The purpose of the project is to assess empirically the connection between the morphology of the travelling shock and strength with observed enhancements in the flow of energized particles in shock accelerated particle (SEP) events (also often identified as "gradual" solar energetic particle events). Activities during this first year centered on the organization of the SEPs events and their correlation with solar wind observations at multiple spacecraft locations. From an identified list of more than 30 SEPs events at multiple spacecraft locations, currently four single cases for detailed study were selected and are in an advance phase of preparation for publication. Preliminary results of these four cases were presented at AGU Spring and Fall 2003 meetings, and other meetings on SEPs.

Effects of aeroconvective environments on 2D reinforced ceramic matrix composites

NASA Technical Reports Server (NTRS)

Riccitiello, Salvatore R.; Love, Wendell L.; Balter-Peterson, Aliza; Hood, Thomas; Chang, William

1991-01-01

The effect of aeroconvective heating environment similar to that observed a spacecraft ascent or reentry from orbit, on the performance of a commercial carbon-reinforced ceramic matrix material specimens of two configurations (orthotropic and quasi-isotropic), fabricated by the Societe Europenne Propulsion (SEP) process was investigated using the NASA Ames Research Center 20 Megawatt Panel Test facility. The performance of the commercial material was compared with the SEP prepared materials. It was found that, whereas the quasi-isotropic SEP specimens exhibited a much higher mass loss rate and a significant dimensional change upon exposure to the thermal environment than did the orthotropic ones, the commercial SEP-like materials did not exhibit these characteristics. There was no greater mass loss rate for the quasi-isotropic specimens, and no dimension changes were observed. The Nicalon reinforced materials in both configurations, as fabricated by SEP or by the commercial source, showed no mass changes and no dimensional changes.

22 CFR 62.45 - Reinstatement to valid program status.

Code of Federal Regulations, 2010 CFR

2010-04-01

... Section 62.45 Foreign Relations DEPARTMENT OF STATE PUBLIC DIPLOMACY AND EXCHANGES EXCHANGE VISITOR PROGRAM Status of Exchange Visitors § 62.45 Reinstatement to valid program status. (a) Definitions. For purpose of this section— You means the Responsible Officer or Alternate Responsible Officer; Exchange...

Effect of ischaemia on somatosensory evoked potentials in diabetic patients.

PubMed Central

López-Alburquerque, T; García Miguel, A; Ruiz Ezquerro, J J; de Portugal Alvarez, J

1987-01-01

The nerve action potential at the elbow and somatosensory evoked potentials (SEPs) at the scalp were recorded over 30 minutes of tourniquet-induced limb ischaemia in 10 diabetic patients and 10 controls. According to the SEP changes, an increased resistance to nerve ischaemia in diabetic patients was observed. The pathways involved in SEP conduction are discussed. PMID:3585354

East Europe Report

DTIC Science & Technology

1986-01-17

Sep 85) 82 Polish-USSR Chemical Industry Agreements (RZECZPOSPOLITA, 12 Sep 85) 84 Trade Deals at Mining, Metallurgy Fair (Marian Twarog...RZECZPOSPOLITA, 11 Sep 85) 89 Briefs Stargard-Gdansk Rail Electrification 90 Polish-Libyan Trade Talks 90 ROMANIA New Sources of Raw Material for...approximately 20,000 leaving students will start an apprenticeship in agriculture. Boys and girls have a choice of 18 trades . Effective 1 September

Technology, design, simulation, and evaluation for SEP-hardened circuits

NASA Technical Reports Server (NTRS)

Adams, J. R.; Allred, D.; Barry, M.; Rudeck, P.; Woodruff, R.; Hoekstra, J.; Gardner, H.

1991-01-01

This paper describes the technology, design, simulation, and evaluation for improvement of the Single Event Phenomena (SEP) hardness of gate-array and SRAM cells. Through the use of design and processing techniques, it is possible to achieve an SEP error rate less than 1.0 x 10(exp -10) errors/bit-day for a 9O percent worst-case geosynchronous orbit environment.

Round-Trip Solar Electric Propulsion Missions for Mars Sample Return

NASA Technical Reports Server (NTRS)

Bailey, Zachary J.; Sturm, Erick J.; Kowalkowski, Theresa D.; Lock, Robert E.; Woolley, Ryan C.; Nicholas, Austin K.

2014-01-01

Mars Sample Return (MSR) missions could benefit from the high specific impulse of Solar Electric Propulsion (SEP) to achieve lower launch masses than with chemical propulsion. SEP presents formulation challenges due to the coupled nature of launch vehicle performance, propulsion system, power system, and mission timeline. This paper describes a SEP orbiter-sizing tool, which models spacecraft mass & timeline in conjunction with low thrust round-trip Earth-Mars trajectories, and presents selected concept designs. A variety of system designs are possible for SEP MSR orbiters, with large dry mass allocations, similar round-trip durations to chemical orbiters, and reduced design variability between opportunities.

Workshop on Solar Electric Propulsion

NASA Technical Reports Server (NTRS)

Bents, David; Marvin, Dean

1993-01-01

A summary of the discussion at the workshop on solar electric propulsion (SEP) is presented. The purpose of ELITE SEP flight experiment is to demonstrate operation of solar array powered electric thrusters for raising spacecraft from parking orbit to higher altitudes, leading to definition of an operational SEP orbit transfer vehicles (OTV) for Air Force missions. Many of the problems or potential problems that may be associated with SEP are not well understood nor clearly identified, and system level phenomena such as interaction of thruster plume with the solar arrays cannot be simulated in a ground test. Therefore, an end-to-end system flight test is required to demonstrate solar electric propulsion.

Workshop on Solar Electric Propulsion

NASA Astrophysics Data System (ADS)

Bents, David; Marvin, Dean

1993-05-01

A summary of the discussion at the workshop on solar electric propulsion (SEP) is presented. The purpose of ELITE SEP flight experiment is to demonstrate operation of solar array powered electric thrusters for raising spacecraft from parking orbit to higher altitudes, leading to definition of an operational SEP orbit transfer vehicles (OTV) for Air Force missions. Many of the problems or potential problems that may be associated with SEP are not well understood nor clearly identified, and system level phenomena such as interaction of thruster plume with the solar arrays cannot be simulated in a ground test. Therefore, an end-to-end system flight test is required to demonstrate solar electric propulsion.

Advancement of a 30K W Solar Electric Propulsion System Capability for NASA Human and Robotic Exploration Missions

NASA Technical Reports Server (NTRS)

Smith, Bryan K.; Nazario, Margaret L.; Manzella, David H.

2012-01-01

Solar Electric Propulsion has evolved into a demonstrated operational capability performing station keeping for geosynchronous satellites, enabling challenging deep-space science missions, and assisting in the transfer of satellites from an elliptical orbit Geostationary Transfer Orbit (GTO) to a Geostationary Earth Orbit (GEO). Advancing higher power SEP systems will enable numerous future applications for human, robotic, and commercial missions. These missions are enabled by either the increased performance of the SEP system or by the cost reductions when compared to conventional chemical propulsion systems. Higher power SEP systems that provide very high payload for robotic missions also trade favorably for the advancement of human exploration beyond low Earth orbit. Demonstrated reliable systems are required for human space flight and due to their successful present day widespread use and inherent high reliability, SEP systems have progressively become a viable entrant into these future human exploration architectures. NASA studies have identified a 30 kW-class SEP capability as the next appropriate evolutionary step, applicable to wide range of both human and robotic missions. This paper describes the planning options, mission applications, and technology investments for representative 30kW-class SEP mission concepts under consideration by NASA

Lifecourse socioeconomic position and 16 year body mass index trajectories: differences by race and sex.

PubMed

Insaf, Tabassum Z; Shaw, Benjamin A; Yucel, Recai M; Chasan-Taber, Lisa; Strogatz, David S

2014-10-01

The aim of this study is to evaluate the association between lifecourse socioeconomic position (SEP) and changes in body mass index (BMI), and assess disparities in these associations across racial/ethnic groups. With longitudinal data from 4 waves of the Americans' Changing Lives Study (1986-2002), we employed mixed-effects modeling to estimate BMI trajectories for 1174 Blacks and 2323 White adults. We also estimated associations between these trajectories and lifecourse SEP variables, including father's education, perceived childhood SEP, own education, income, wealth, and financial security. Blacks had higher baseline BMIs, and steeper increases in BMI, compared to Whites. Childhood SEP, as measured by high father's education, was associated with lower baseline BMI among Whites. High education was associated with a lower baseline BMI within both race and sex categories. Income had contrasting effects among men and women. Higher income was associated with higher BMI only among males. Associations between indicators of SEP and BMI trajectories were only found for Whites. Our study demonstrates that lifecourse SEP may influence adult BMI differently within different racial and sex groups. Copyright © 2014 Elsevier Inc. All rights reserved.

Race/Ethnicity, Life-Course Socioeconomic Position, and Body Weight Trajectories Over 34 years: The Alameda County Study

PubMed Central

Baltrus, Peter T.; Lynch, John W.; Everson-Rose, Susan; Raghunathan, Trivellore E.; Kaplan, George A.

2005-01-01

Objectives. We investigated whether race differences in weight gain over 34 years were because of socioeconomic position (SEP) and psychosocial and behavioral factors (physical activity, cigarette smoking, alcohol consumption, depression, marital status, number of children). We used a life-course approach to SEP with 4 measures of SEP (childhood SEP, education, occupation, income) and a cumulative measure of SEP. Methods. We used mixed models and data collected from the Alameda County Study to examine the association between race and weight change slopes and baseline weight in men (n=1186) and women (n=1375) aged 17 to 40 years at baseline (in 1965). Results. All subjects gained weight over time. African American women weighed 4.96 kg (P < .001) more at baseline and gained 0.10 kg/year (P = .043) more weight than White women. Black men weighed 2.41 kg (P= .006) more at baseline but did not gain more weight than White men. The association of race with weight gain in women was largely because of cumulative SEP score. Conclusions. Interventions to prevent overweight and obesity should begin early in life and target the socioeconomically disadvantaged. PMID:16051936

Socioeconomic position and occupational social class and their association with risky alcohol consumption among adolescents.

PubMed

Obradors-Rial, Núria; Ariza, Carles; Rajmil, Luis; Muntaner, Carles

2018-05-01

To compare different measures of socioeconomic position (SEP) and occupational social class (OSC) and to evaluate their association with risky alcohol consumption among adolescents attending the last mandatory secondary school (ages 15-17 years). This was a cross-sectional study. 1268 adolescents in Catalonia (Spain) participated in the study. Family affluence scale (FAS), parents' OSC, parents' level of education and monthly familiar income were used to compare socioeconomic indicators. Logistic regression analyses were conducted to evaluate socioeconomic variables and missing associated factors, and to observe the relation between each SEP variable and OSC adjusting by sociodemographic variables. Familiar income had more than 30% of missing values. OSC had the fewest missing values associated factors. Being immigrant was associated with all SEP missing values. All SEP measures were positively associated with risky alcohol consumption, yet the strength of these associations diminished after adjustment for sociodemographic variables. Weekly available money was the variable with the strongest association with risky alcohol consumption. OSC seems to be as good as the other indicators to assess adolescents' SEP. Adolescents with high SEP and those belonging to upper social classes reported higher levels of risky alcohol consumption.

Socioeconomic conditions across life related to multiple measures of the endocrine system in older adults: Longitudinal findings from a British birth cohort study.

PubMed

Bann, David; Hardy, Rebecca; Cooper, Rachel; Lashen, Hany; Keevil, Brian; Wu, Frederick C W; Holly, Jeff M P; Ong, Ken K; Ben-Shlomo, Yoav; Kuh, Diana

2015-12-01

Little is known about how socioeconomic position (SEP) across life impacts on different axes of the endocrine system which are thought to underlie the ageing process and its adverse consequences. We examined how indicators of SEP across life related to multiple markers of the endocrine system in late midlife, and hypothesized that lower SEP across life would be associated with an adverse hormone profile across multiple axes. Data were from a British cohort study of 875 men and 905 women followed since their birth in March 1946 with circulating free testosterone and insulin-like growth factor-I (IGF-I) measured at both 53 and 60-64 years, and evening cortisol at 60-64 years. Indicators of SEP were ascertained prospectively across life-paternal occupational class at 4, highest educational attainment at 26, household occupational class at 53, and household income at 60-64 years. Associations between SEP and hormones were investigated using multiple regression and logistic regression models. Lower SEP was associated with lower free testosterone among men, higher free testosterone among women, and lower IGF-I and higher evening cortisol in both sexes. For example, the mean standardised difference in IGF-I comparing the lowest with the highest educational attainment at 26 years (slope index of inequality) was -0.4 in men (95% CI -0.7 to -0.2) and -0.4 in women (-0.6 to -0.2). Associations with each hormone differed by SEP indicator used and sex, and were particularly pronounced when using a composite adverse hormone score. For example, the odds of having 1 additional adverse hormone concentration in the lowest compared with highest education level were 3.7 (95% CI: 2.1, 6.3) among men, and 1.6 (1.0, 2.7) among women (P (sex interaction) = 0.02). We found no evidence that SEP was related to apparent age-related declines in free testosterone or IGF-I. Lower SEP was associated with an adverse hormone profile across multiple endocrine axes. SEP differences in endocrine function may partly underlie inequalities in health and function in later life, and may reflect variations in biological rates of ageing. Further studies are required to assess the likely functional relevance of these associations. Copyright © 2015 The Authors. Published by Elsevier Ltd.. All rights reserved.

[What compensatory motor strategies do patients with multiple sclerosis develop for balance control?].

PubMed

Rougier, P; Thoumie, P; Cantalloube, S; Lamotte, D

2007-11-01

One of the main features of multiple sclerosis (MS) is the deterioration of motor pathway axons, and in some cases, sensory system axons. Consequently, experimental sensori-motor testing with the undisturbed upright stance paradigm might be useful. It can be hypothesized that the postural strategies could be differently affected depending on the degree of dysfunction of both sensory and motor tracts. Twelve and fifteen patients, classified from sensory clinical tests as ataxo-spastic (SEP-AS) or only spastic (SEP-S), respectively were included in this study and compared to 12 healthy adults matched for age. The postural strategies were assessed from the centre of pressure trajectories (CP), measured from the force platform on which the subjects were instructed to stand upright eyes open for a trial lasting 51.2 s. biomechanical modelling was applied to these trajectories to compute the movements of the centre of gravity (CG) and consequently, the vertical difference between the CP and then the CP-CG, two elementary movements known to characterize postural performance movements for CGv and horizontal acceleration communicated to the CG for the CP-CG movements, and consequently overall neuro-muscular activity. To estimate the relative contribution of each of these elementary movements, an analysis based on frequency parameters (RMS and MF) was conducted. Both SEP-AS and SEP-S groups demonstrate larger CG and CP-CG movements than the age paired individuals. However, some statistically significant differences has to be emphasised between the two MS subgroups but only for the CP-CG component: the RMS of these movements are largely increased for the SEP-AS group, as compared to the SEP-S one. Biomechanically, this feature expresses the necessity for these very patients to produce exaggerated horizontal forces, and thus an increased energy expenditure, to handle the CG movements. The lack of effect observed for the CG movements underlines the capacity for the SEP-AS group to set appropriate control mechanisms for counteracting these less favourable initial conditions. By demonstrating specific trends in the postural organisation aimed at controlling undisturbed upright stance maintenance, this study can be of interest for the practitioner by legitimating this experimental paradigm as a simple and non invasive way to diagnose appropriately the sensori-motor deficiency.

Faculty-Exchange Programs Promoting Change: Motivations, Experiences, and Influence of Participants in the Carnegie Mellon University-Portugal Faculty Exchange Program

ERIC Educational Resources Information Center

Patrício, Maria Teresa; Santos, Patrícia; Loureiro, Paulo Maia; Horta, Hugo

2018-01-01

The international mobility of faculty is increasing worldwide. Although studies have considered the experiences of academics abroad, less is known about faculty-exchange programs with policy objectives. This study helps to fill this gap by analyzing a nationwide structured faculty exchange program established by Carnegie Mellon University and…

Solar Particle Radiation Storms Forecasting and Analysis within the Framework of the `HESPERIA' HORIZON 2020 Project

NASA Astrophysics Data System (ADS)

Posner, A.; Malandraki, O.; Nunez, M.; Heber, B.; Labrenz, J.; Kühl, P.; Milas, N.; Tsiropoula, G.; Pavlos, E.

2017-12-01

Two prediction tools that have been developed in the framework of HESPERIA based upon the proven concepts UMASEP and REleASE. Near-relativistic (NR) electrons traveling faster than ions (30 MeV protons have 0.25c) are used to forecast the arrival of protons of Solar Energetic Particle (SEP) events with real-time measurements of NR electrons. The faster electrons arrive at L1 30 to 90 minutes before the slower protons. REleASE (Relativistic Electron Alert System for Exploration, Posner, 2007) uses this effect to predict the proton flux by utilizing actual electron fluxes and their most recent increases. Through HESPERIA, a clone of REleASE was built in open source programming language. The same forecasting principle was adapted to real-time data from ACE/EPAM. It is shown that HESPERIA REleASE forecasting works with any NR electron flux measurements. >500 MeV solar protons are so energetic that they usually have effects on the ground, producing Ground Level Enhancement (GLE) events. Within HESPERIA, a predictor of >500 SEP proton events near earth (geostationary orbit) has been developed. In order to predict these events, UMASEP (Núñez, 2011, 2015) has been used. UMASEP makes a lag-correlation of solar electromagnetic (EM) flux with the particle flux near earth. If the correlation is high, the model infers that there is a magnetic connection through which particles are arriving. If, additionally, the intensity of the flux of the associated solar event is also high, then UMASEP issues a SEP prediction. In the case of the prediction of >500 MeV SEP events, the implemented system, called HESPERIA UMASEP-500, correlates X-ray flux with differential proton fluxes by GOES, and with fluxes collected by neutron monitor stations around the world. When the correlation estimation and flare surpasses thresholds, a >500 MeV SEP forecast is issued. These findings suggest that a synthesis of the various approaches may improve over the status quo. Both forecasting tools are operational on the HESPERIA server maintained at the National Observatory of Athens (https://www.hesperia.astro.noa.gr/). This project received funding from the EU's Horizon 2020 research and innovation programme under grant No 637324.

Adsorption, Ordering, and Local Environments of Surfactant-Encapsulated Polyoxometalate Ions Probed at the Air–Water Interface

DOE PAGES

Doughty, Benjamin; Yin, Panchao; Ma, Ying-Zhong

2016-07-23

The continued development and application of surfactant-encapsulated polyoxometalates (SEPs) relies on understanding the ordering and organization of species at their interface and how these are impacted by the various local environments to which they are exposed. In this paper, we report on the equilibrium properties of two common SEPs adsorbed to the air–water interface and probed with surface-specific vibrational sum-frequency generation (SFG) spectroscopy. These results reveal clear shifts in vibrational band positions, the magnitude of which scales with the charge of the SEP core, which is indicative of a static field effect on the surfactant coating and the associated localmore » chemical environment. This static field also induces ordering in surrounding water molecules that is mediated by charge screening via the surface-bound surfactants. From these SFG measurements, we are able to show that Mo 132-based SEPs are more polar than Mo 72V 30 SEPs. Disorder in the surfactant chain packing at the highly curved SEP surfaces is attributed to large conic volumes that can be sampled without interactions with neighboring chains. Measurements of adsorption isotherms yield free energies of adsorption to the air–water interface of -46.8 ± 0.4 and -44.8 ± 1.2 kJ/mol for the Mo 132 and Mo 72V 30 SEPs, respectively, indicating a strong propensity for the fluid surface. Finally, the influence of intermolecular interactions on the surface adsorption energies is discussed.« less

The Connection Between the Longitudinal Extent of SEP Events and the Properties of Coronal Shocks

NASA Astrophysics Data System (ADS)

Raouafi, N. E.; Lario, D.; Kwon, R. Y.; Riley, P.

2016-12-01

Under the paradigm that the acceleration of solar energetic particles (SEPs) is mainly due to shocks initially driven by coronal mass ejections (CMEs), the observation of a SEP event (generated by a single solar eruption) from distant heliospheric locations poses the question of whether shocks are at the origin of the wide-longitudinal spread of the SEP events. The combination of remote-sensing observations of the corona in extreme ultraviolet (EUV) and white-light (WL) images obtained from multiple vantage points allows us to reconstruct the 3D large-scale structure of the coronal shocks formed around CMEs, and hence estimate the speed of their fronts. On the other hand, coronal magnetohydrodynamic (MHD) simulations allow us to estimate the characteristics of the medium where the shocks propagate and expand. The extent of the shocks and their capability to accelerate SEPs depend on the properties of this medium. We analyze, for the well-studied SEP events of 11 Apr 2013 and 25 Feb 2014 observed by the two STEREO spacecraft and near-Earth observers [Lario et al., 2014, 2016], whether (1) the extent of the shocks as seen in EUV and WL images are determined by the pre-event medium background provided by the MHD simulations, and (2) the properties of the associated shocks at different longitudes are consistent with the thesis that the SEPs observed by the different spacecraft are accelerated and injected by the expanding shocks.

Binding of dicamba to soluble and bound extracellular polymeric substances (EPS) from aerobic activated sludge: a fluorescence quenching study.

PubMed

Pan, Xiangliang; Liu, Jing; Zhang, Daoyong; Chen, Xi; Song, Wenjuan; Wu, Fengchang

2010-05-15

Binding of dicamba to soluble EPS (SEPS) and bound EPS (BEPS) from aerobic activated sludge was investigated using fluorescence spectroscopy. Two protein-like fluorescence peaks (peak A with Ex/Em=225 nm/342-344 nm and peak B with Ex/Em=275/340-344 nm) were identified in SEPS and BEPS. Humic-like fluorescence peak C (Ex/Em=270-275 nm/450-460 nm) was only found in BEPS. Fluorescence of the peaks A and B for SEPS and peak A for BEPS were markedly quenched by dicamba at all temperatures whereas fluorescence of peaks B and C for BEPS was quenched only at 298 K. A dynamic process dominated the fluorescence quenching of peak A of both SEPS and BEPS. Fluorescence quenching of peak B and C was governed a static process. The effective quenching constants (logK(a)) were 4.725-5.293 for protein-like fluorophores of SEPS and 4.23-5.190 for protein-like fluorophores of BEPS, respectively. LogK(a) for humic-like substances was 3.85. Generally, SEPS had greater binding capacity for dicamba than BEPS, and protein-like substances bound dicamba more strongly than humic-like substances. Binding of dicamba to SEPS and BEPS was spontaneous and exothermic. Electrostatic force and hydrophobic interaction forces play a crucial role in binding of dicamba to EPS. Copyright © 2010 Elsevier Inc. All rights reserved.

Charge and pressure-tuned surface patterning of surfactant-encapsulated polyoxometalate complexes at the air-water interface.

PubMed

Xu, Miao; Li, Haolong; Zhang, Liying; Wang, Yizhan; Yuan, Yuan; Zhang, Jianming; Wu, Lixin

2012-10-16

In this paper, four organic-inorganic hybrid complexes were prepared using a cationic surfactant dimethyldioctadecylammonium (DODA) to replace the counter cations of four Keggin-type polyoxometalate (POM) clusters with gradually increased negative charges, PW(12)O(40)(3-), SiW(12)O(40)(4-), BW(12)O(40)(5-), and CoW(12)O(40)(6-). The formed surfactant-encapsulated POM (SEP) complexes showed typical amphiphilic properties and can be spread onto the air-water interface to form Langmuir monolayers. The interfacial behavior of the SEP monolayer films was systemically studied by multiple in situ and ex situ characterization methods including Brewster angle microscopy (BAM), atomic force microscopy (AFM), reflection-absorption infrared (RAIR), and X-ray photoelectron spectroscopy (XPS). We found that the increasing alkyl chain density of SEPs leads to an enhanced stability and a higher collapse pressure of SEP Langmuir monolayers. Moreover, a second layer evolved as patterns from the initial monolayers of all the SEPs, when the surface pressures approached the collapse values. The rational combination of alkyl chain density and surface pressure can precisely control the size and the morphology of SEP patterns transforming from disk-like to leaf-like structures on a micrometer scale. The pattern formation was demonstrated to be driven by the self-optimized surface energy of SEP monolayers. This finding can direct a new strategy for the fabrication of POM-hybrid films with controllable patterns, which should be instructive for designing POM-based thin film devices.

78 FR 76187 - 30-Day Notice of Proposed Information Collection: Exchange Programs Alumni Web Site Registration

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-16

...: Exchange Programs Alumni Web Site Registration ACTION: Notice of request for public comment and submission... Information Collection: Exchange Programs Alumni Web site Registration. OMB Control Number: 1405-0192. Type of... proposed collection: The International Exchange Alumni Web site requires information to process users...

Architecutres, Models, Algorithms, and Software Tools for Configurable Computing

DTIC Science & Technology

2000-03-06

and J.G. Nash. The gated interconnection network for dynamic programming. Plenum, 1988 . [18] Ju wook Jang, Heonchul Park, and Viktor K. Prasanna. A ...Sep. 1997. [2] C. Ebeling, D. C. Cronquist , P. Franklin and C. Fisher, "RaPiD - A configurable computing architecture for compute-intensive...ABSTRACT (Maximum 200 words) The Models, Algorithms, and Architectures for Reconfigurable Computing (MAARC) project developed a sound framework for

Maximum Grasping Reach of Operators Possessing Functional Impairments of the Upper Extremities.

DTIC Science & Technology

1978-12-01

ADDRESS 10. PROGRAM ELEMENT, PROJECT, TASK AFITStudent at: Texas A&M University AREA & WORK UNIT NUMBERS II. CONTROLLING OFFICENA E AND AD_. . 12...RELEASE AFR 190.172 Ja e I 10, t USAF 23 SEP 1980 , ’ 1"lic Aar* e IS. SUPPLEMENTARY NOTES Approved for public release; IAW AFR 190-17 Air Force...C .. .... ..... ..... .... 141 APPENDIX D .. ... ...... ..... .... 184 APPENDIX E .. ... ..... ...... .... 187 APPENDIX F .. .... ..... ..... .... 189

Rational Selection of Tailored Amendment Mixtures and Composites for In Situ Remediation of Contaminated Sediments

DTIC Science & Technology

2008-12-01

Certification Program GAC granular activated carbon HGR sulfur impregnated activated carbon MCA Menzie Cura and Associates MRM Minimum Required...determination of iodine number was followed. The materials tested were granular activated carbon (GAC), alumina powder, ATS, apatite, bentonite, barite...materials tested were granular activated carbon (GAC), alumina powder, ATS, apatite, bentonite, barite, ConSep 20 and 42%, and ATC. The Iodine Number

Muscle Contraction Arrests Tumor Growth

DTIC Science & Technology

2006-09-01

AD_________________ Award Number: W81XWH-05-1-0464 TITLE: Muscle Contraction Arrests Tumor Growth...DATE 01-09-2006 2. REPORT TYPE Annual 3. DATES COVERED 1 Sep 2005 – 31 Aug 2006 4. TITLE AND SUBTITLE 5a. CONTRACT NUMBER Muscle ... Contraction Arrests Tumor Growth 5b. GRANT NUMBER W81XWH-05-1-0464 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) Kim Westerlind, Ph.D. 5d. PROJECT NUMBER

Task Force Fury - 4/82 ABN. Operation Enduring Freedom X, Aug 09-Sep 10

DTIC Science & Technology

2012-06-01

UNIT NUMBER 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) Office Secretary of Defense,Joint Advanced Warfighting Program - Analytical Projects...Office,Washington,DC,20301 8. PERFORMING ORGANIZATION REPORT NUMBER 9. SPONSORING/MONITORING AGENCY NAME(S) AND ADDRESS(ES) 10. SPONSOR/MONITOR’S...assess our Operational Environments (OE), Afghan partners and ourselves - Remain an agile, adaptive and learning organization (get better every day) ANSF

Physical and chemical properties of aerosols at a coastal site Paposo (Chile) during VOCALS campaign

NASA Astrophysics Data System (ADS)

Cordova, A. M.; Chand, D.; Wood, R.; Wallace, D.; Hegg, D. A.; Shaw, G. E.; Krejci, R.; Fochesatto, G. J.; Gallardo, L.

2009-12-01

One of the primary goals of the VOCALS (VAMOS* Ocean-Cloud-Atmosphere-Land Study) Regional Experiment (REx) and associated modeling program is an improved understanding of aerosol indirect effects over the southeast Pacific (SEP). Details on the program are available online at www.eol.ucar.edu/projects/vocals/. To this end, detailed aerosol physical and chemical measurements were made during REx at a coastal land site at Paposo (25o 0.4' S, 70o 27.011' W, 690 masl) in northern Chile, a site ideally positioned for studying continental aerosol sources advecting over the SEP. We present initial analysis of data from Paposo. Detailed measurements of aerosol properties were made from mid October to mid November 2008. Observations from optical particle counters (OPC), nephelometers, aethalometer, scanning mobility particle sizer (SMPS) and the chemical analysis of the submicron aerosols samples collected on teflon filters are being used in this study. Large variations in aerosols parameters were observed which corresponded with changes in meteorology, as determined using trajectory analysis. Ion Chromatograph (IC) analysis of submicron aerosol samples shows that about 41% of submicron mass is sulfate. The light scattering coefficient shows a strong non-linear correlation with aerosol size observed using an OPC. Detailed results will be presented in the AGU meeting.

In-Space Transportation for NASA's Evolvable Mars Campaign

NASA Technical Reports Server (NTRS)

Percy, Thomas K.; McGuire, Melissa; Polsgrove, Tara

2015-01-01

As the nation embarks on a new and bold journey to Mars, significant work is being done to determine what that mission and those architectural elements will look like. The Evolvable Mars Campaign, or EMC, is being evaluated as a potential approach to getting humans to Mars. Built on the premise of leveraging current technology investments and maximizing element commonality to reduce cost and development schedule, the EMC transportation architecture is focused on developing the elements required to move crew and equipment to Mars as efficiently and effectively as possible both from a performance and a programmatic standpoint. Over the last 18 months the team has been evaluating potential options for those transportation elements. One of the key aspects of the EMC is leveraging investments being made today in missions like the Asteroid Redirect Mission (ARM) mission using derived versions of the Solar Electric Propulsion (SEP) propulsion systems and coupling them with other chemical propulsion elements that maximize commonality across the architecture between both transportation and Mars operations elements. This paper outlines the broad trade space being evaluated including the different technologies being assessed for transportation elements and how those elements are assembled into an architecture. Impacts to potential operational scenarios at Mars are also investigated. Trades are being made on the size and power level of the SEP vehicle for delivering cargo as well as the size of the chemical propulsion systems and various mission aspects including Inspace assembly and sequencing. Maximizing payload delivery to Mars with the SEP vehicle will better support the operational scenarios at Mars by enabling the delivery of landers and habitation elements that are appropriately sized for the mission. The purpose of this investigation is not to find the solution but rather a suite of solutions with potential application to the challenge of sending cargo and crew to Mars. The goal is that, by building an architecture intelligently with all aspects considered, the sustainable Mars program wisely invests limited resources enabling a long-term human Mars exploration program.

East Europe Report

DTIC Science & Technology

1986-10-15

POLITIKA, 1 Sep 86) ..... 45 Burden of Excessive State Administration Deplored (Slaven Letica Interview; EKONOMSKA POLITIKA, 1 Sep 86) ... 50 POLITICS...BURDEN OF EXCESSIVE STATE ADMINISTRATION DEPLORED Belgrade EKONOMSKA POLITIKA in Serbo-Croatian 1 Sep 86 pp 15-17 [Interview with Dr Slaven Letica ...our situation with Dr Slaven Letica , professor of health care economics at the Zagreb School of Medicine, UN consultant in this field, and one of the

Association of expression of selenoprotein P in mRNA and protein levels with metabolic syndrome in subjects with cardiovascular disease: Results of the Selenegene study.

PubMed

Gharipour, Mojgan; Sadeghi, Masoumeh; Salehi, Mansour; Behmanesh, Mehrdad; Khosravi, Elham; Dianatkhah, Minoo; Haghjoo Javanmard, Shaghayegh; Razavi, Rouzbeh; Gharipour, Amin

2017-03-01

Selenoprotein P (SeP) is involved in transporting selenium from the liver to target tissues. Because SeP confers protection against disease by reducing chronic oxidative stress, the present study aimed to assess the level of SeP in the serum of patients with metabolic syndrome (MetS) with a history of cardiovascular disease (CVD). A cross-sectional study was conducted in 63 and 71 subjects with and without MetS in the presence of documented CVD. All demographic, anthropometric and cardiometabolic variables (lipids, blood glucose, blood pressure) were assessed. Lifestyle-related factors and personal history and familial CVD risk factors were recorded. The expression of SELP in mRNA and protein levels in the serum was measured, and MetS was determined using ATPIII criteria. Binary logistic regression analysis demonstrated MetS and SeP to be dependent and independent variables, respectively. Mean of systolic and diastolic blood pressure, triglyceride, high-density lipoprotein-cholesterol, fasting blood sugar, body mass index and waist circumference were higher among subjects with MetS (p = 0.05). The mean of selenium was higher among subjects with MetS, whereas the mean of SeP was lower among subjects with MetS (p < 0.001). In the unadjusted model, the SeP had decreased odds for MetS [odds ratio (OR) = 0.995; 95% confidence interval (CI) = 0.989-1.00] (p < 0.04). Furthermore, the association between MetS and SeP levels remained marginally significant even after adjusting for potential confounders such as age, gender, family history, smoking status and nutrition. SeP and waist circumference show a significant relationship (OR =0.995; 95% CI = 0.990-1.00) (p < 0.033). We have demonstrated a significant decrease in circulating SeP levels according to MetS status in patients with documented cardiovascular disease. Copyright © 2017 John Wiley & Sons, Ltd.

Solar Sentinels: Report of the Science and Technology Definition Team

NASA Technical Reports Server (NTRS)

2006-01-01

The goal of NASA s Living With a Star (LWS) program is to develop the scientific understanding necessary to effectively address those aspects of the connected Sun Earth system that directly affect life and society. Along with the other elements of LWS, Solar Sentinels aims to discover, understand, and model the heliospheric initiation, propagation, and solar connection of those energetic phenomena that adversely affect space exploration and life and society here on Earth. The Solar Sentinels mission will address the following questions: (1) How, where, and under what circumstances are solar energetic particles (SEPs) accelerated to high energies and how do they propagate through the heliosphere? And (2) How are solar wind structures associated with these SEPs, like CMEs, shocks, and high-speed streams, initiated, propagate, evolve, and interact in the inner heliosphere? The Sentinels STDT recommends implementing this mission in two portions, one optimized for inner heliospheric in-situ measurements and the other for solar remote observations. Sentinels will greatly enhance the overall LWS science return.

Fostering internationalization: an American-Danish semester-long undergraduate nursing student exchange program.

PubMed

Baernholdt, M; Drake, E; Maron, F; Neymark, K

2013-06-01

This paper describes the development, implementation and evaluation of a semester-long exchange program between two Bachelor of Science in Nursing programs in the USA and Denmark. Nurses globally need to provide culturally sensitive care for an ethnically diverse population. Competencies on how to do so should start in basic nursing programs. A useful strategy is through immersion into another culture through an exchange program. Little is known about successful strategies for two-way or 360° exchange programs between schools from different countries. Guided by experiential learning theory, we developed an exchange program with the objective of enhancing nursing students' cultural competence through knowledge building, attitudes and behaviour development. Lessons learned and implications for educational institutions and policy are discussed. In internationalization of nursing education, an awareness of underlying cultural values regarding nursing competence and taking appropriate action are important for success. Other areas for a successful exchange program include matching of courses or content across schools, clear objectives and evaluation plans. Finally, flexibility and open communication are key components when setting up a 360° exchange program. © 2013 The Authors. International Nursing Review © 2013 International Council of Nurses.

Low-thrust trajectory analysis for the geosynchronous mission

NASA Technical Reports Server (NTRS)

Jasper, T. P.

1973-01-01

Methodology employed in development of a computer program designed to analyze optimal low-thrust trajectories is described, and application of the program to a Solar Electric Propulsion Stage (SEPS) geosynchronous mission is discussed. To avoid the zero inclination and eccentricity singularities which plague many small-force perturbation techniques, a special set of state variables (equinoctial) is used. Adjoint equations are derived for the minimum time problem and are also free from the singularities. Solutions to the state and adjoint equations are obtained by both orbit averaging and precision numerical integration; an evaluation of these approaches is made.

Global Temperature and Salinity Pilot Project

NASA Technical Reports Server (NTRS)

Searle, Ben

1992-01-01

Data exchange and data management programs have been evolving over many years. Within the international community there are two main programs to support the exchange, management and processing of real time and delayed mode data. The Intergovernmental Oceanographic Commission (IOC) operate the International Oceanographic Data and Information Exchange (IODE) program which coordinates the exchange of delayed mode data between national oceanographic data centers, World Data Centers and the user community. The Integrated Global Ocean Services System is a joint IOC/World Meteorological Organization (WMO) program for the exchange and management of real-time data. These two programs are complemented by mechanisms that have been established within scientific programs to exchange and manage project data sets. In particular TOGA and WOCE have identified a data management requirement and established the appropriate infrastructure to achieve this. Where GTSPP fits into this existing framework is discussed.

Three-Phase Coexistence in Colloidal Rod-Plate Mixtures.

PubMed

Woolston, Phillip; van Duijneveldt, Jeroen S

2015-09-01

Aqueous suspensions of clay particles, such as montmorillonite (MMT) platelets and sepiolite (Sep) rods, tend to form gels at concentrations around 1 vol %. For Sep rods, adsorbing sodium polyacrylate to the surface allows for an isotropic-nematic phase separation to be seen instead. Here, MMT is added to such Sep suspensions, resulting in a complex phase behavior. Across a range of clay concentrations, separation into three phases is observed: a lower, nematic phase dominated by Sep rods, a MMT-rich middle layer, which is weakly birefringent and probably a gel, and a dilute top phase. Analysis of phase volumes suggests that the middle layer may contain as much as 6 vol % MMT.

High-voltage Array Ground Test for Direct-drive Solar Electric Propulsion

NASA Technical Reports Server (NTRS)

Howell, Joe T.; Mankins, John C.; O'Neill, Mark J.

2005-01-01

Development is underway on a unique high-power solar concentrator array called Stretched Lens Array (SLA) for direct drive electric propulsion. These SLA performance attributes closely match the critical needs of solar electric propulsion (SEP) systems, which may be used for "space tugs" to fuel-efficiently transport cargo from low earth orbit (LEO) to low lunar orbit (LLO), in support of NASA s robotic and human exploration missions. Later SEP systems may similarly transport cargo from the earth-moon neighborhood to the Mars neighborhood. This paper will describe the SLA SEP technology, discuss ground tests already completed, and present plans for future ground tests and future flight tests of SLA SEP systems.

Educators Exchange: A Program Evaluation.

ERIC Educational Resources Information Center

Armstrong, William B.

The Educators Exchange Program (EEP) was established under a training and educational exchange agreement reached by California's San Diego Community College District (SDCCD) and the republic of Mexico. In the program, the District provided a 4-week technological training program to faculty at Centros de Capacitacion Tecnologica Industrial…

The subdural evacuation port system: outcomes from a single institution experience and predictors of success.

PubMed

Neal, Matthew T; Hsu, Wesley; Urban, Jillian E; Angelo, Nicole M; Sweasey, Thomas A; Branch, Charles L

2013-06-01

Numerous surgical options for treatment of chronic subdural hematomas (cSDH) exist. Several reports have examined the Subdural Evacuating Port System (SEPS), a variation of the twist drill craniotomy (TDC) technique. Although high success rates have been reported, a significant portion of patients treated with SEPS fail and require additional procedures. This report examines the largest single institution experience with the SEPS and explores patient and imaging characteristics associated with successful procedures. A retrospective chart review was performed to identify all patients who have undergone SEPS drainage of cSDH. Demographic and radiographic characteristics were evaluated. Demographic data included patient's age, sex, presenting symptoms, pre-procedural GCS score, and use of anticoagulation or antiplatelet agents. The volume of drainage per procedure and radiographic data including laterality, density, and maximal diameter of the collection, presence of septations, midline shift, resolution of the collection 3 weeks post procedure, and measurements to assess atrophy were collected. Total length of stay and time in the intensive care unit was also recorded. Results were classified as a success or failure based on the need for additional procedures including craniotomy or burr hole craniotomy in the operating room. Patients treated with two SEPS procedures during the same hospitalization and no other procedures were included in the success group for statistical analyses. 171 subdural collections were treated in 159 patients (147 unilateral and 12 bilateral). One hundred thirty three collections (77.8%) were successfully drained. In a comparison of the success and failure groups, there were no statistically significant differences (p<0.05) in the patients' mean age, sex, presenting Glasgow Coma Scale score, coagulation profile, presenting symptoms (except altered mental status and language disturbance), subdural diameter or laterality, midline shift, presence of atrophy, density of most acute portion, or time in hospital. In the success group, there was a shorter mean stay in the intensive care unit (S: 4.1±4.5 days vs F: 5.4±4.6 days; p=0.03) and a larger output drained (S: 131.1±71.2ml vs F: 99.0±84.2ml; p=0.04). Success was less likely with mixed density collections (S: 38.2% vs F: 64.3%; p=0.02) and with collections containing greater than 2 intrahematomal septations (S: 17.1% vs F: 40.7%; p=0.007). In successful cases, mean volumes for collections prior to SEPS, immediately after SEPS, and on delayed scans (≥30 days since SEPS placement) the respective volumes were 83.1±35.1ml, 41.5±23.2ml, and 37.9±26.5ml. Both post-SEPS volumes were less than the pre-SEPS volume (p<0.0001). 76.0% of patients with delayed scans had complete resolution of cSDH or minimal residual cSDH with no local mass effect on the most recent imaging. The mean period of follow-up imaging was 95.6±196.2 days. Only one patient in our series required an emergent craniotomy following immediate complications from SEPS placement. The SEPS is an effective, safe, and durable treatment for cSDH. Although we consider the SEPS a first-line treatment for the majority of patients with cSDH, management of cSDH must be tailored to each patient. In mixed density collections with large proportions of acute hemorrhage and in collections with numerous intrahematomal septations, alternative surgical techniques should be considered as first-line therapies. Copyright © 2012 Elsevier B.V. All rights reserved.

Mars Earth Return Vehicle (MERV) Propulsion Options

NASA Technical Reports Server (NTRS)

Oleson, Steven R.; McGuire, Melissa L.; Burke, Laura; Fincannon, James; Warner, Joe; Williams, Glenn; Parkey, Thomas; Colozza, Tony; Fittje, Jim; Martini, Mike;

Derivation of relativistic SEP properties through neutron monitor data modeling

NASA Astrophysics Data System (ADS)

Plainaki, C.; Laurenza, M.; Mavromichalaki, H.; Storini, M.; Gerontidou, M.; Kanellakopoulos, A.; Andriopoulou, M.; Belov, A.; Eroshenko, E.; Yanke, V.

2015-08-01

The Ground Level Enhancement (GLE) data recorded by the worldwide Neutron Monitor (NM) network are useful resources for space weather modeling during solar extreme events. The derivation of Solar Energetic Particles (SEPs) properties through NM-data modeling is essential for the study of solar-terrestrial physics, providing information that cannot be obtained through the exclusive use of space techniques; an example is the derivation of the higher-energy part of the SEP spectrum. We briefly review how the application of the Neutron Monitor Based Anisotropic GLE Pure Power Law (NMBANGLE PPOLA) model (Plainaki et al. 2010), can provide the characteristics of the relativistic SEP flux, at a selected altitude in the Earth's atmosphere, during a GLE. Technically, the model treats the NM network as an integrated omnidirectional spectrometer and solves the inverse problem of the SEP-GLE coupling. As test cases, we present the results obtained for two different GLEs, namely GLE 60 and GLE 71, occurring at a temporal distance of ∼ 11 years.

Air shower simulation for WASAVIES: warning system for aviation exposure to solar energetic particles.

PubMed

Sato, T; Kataoka, R; Yasuda, H; Yashiro, S; Kuwabara, T; Shiota, D; Kubo, Y

2014-10-01

WASAVIES, a warning system for aviation exposure to solar energetic particles (SEPs), is under development by collaboration between several institutes in Japan and the USA. It is designed to deterministically forecast the SEP fluxes incident on the atmosphere within 6 h after flare onset using the latest space weather research. To immediately estimate the aircrew doses from the obtained SEP fluxes, the response functions of the particle fluxes generated by the incidence of monoenergetic protons into the atmosphere were developed by performing air shower simulations using the Particle and Heavy Ion Transport code system. The accuracy of the simulation was well verified by calculating the increase count rates of a neutron monitor during a ground-level enhancement, combining the response function with the SEP fluxes measured by the PAMELA spectrometer. The response function will be implemented in WASAVIES and used to protect aircrews from additional SEP exposure. © The Author 2013. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

Simultaneous Modeling of Gradual SEP Events at the Earth and the Mars

NASA Astrophysics Data System (ADS)

Hu, J.; Li, G.

2017-12-01

Solar Energetic Particles (SEP) event is the number one space hazard for spacecraft instruments and astronauts' safety. Recent studies have shown that both longitudinal and radial extent of SEP events can be very significant. In this work, we use the improved Particle Acceleration and Transport in the Heliosphere (iPATH) model to simulate gradual SEP events that have impacts upon both the Earth and the Mars. We follow the propagation of a 2D CME-driven shock. Particles are accelerated at the shock via the diffusive shock acceleration (DSA) mechanism. Transport of the escaped particles to the Earth and the Mars is then followed using a backward stochastic differential equation method. Perpendicular diffusion is considered in both the DSA and the transport process. Model results such as time intensity profile and energetic particle spectrum at the two locations are compared to understand the spatial extent of an SEP event. Observational data at the Earth and the Mars are also studied to validate the model.

Sensory physiology assessed by evoked potentials in survivors of poliomyelitis.

PubMed

Prokhorenko, Olga A; Vasconcelos, Olavo M; Lupu, Vitalie D; Campbell, William W; Jabbari, Bahman

2008-10-01

Evidence suggests that sensory loss may occur in a proportion of patients affected by poliomyelitis. We hypothesize that sensory problems may be a lasting sequela in some polio survivors. Sensory pathways in polio survivors were evaluated clinically and electrophysiologically using sensory evoked potentials (SEPs). Patients with sensory deficits or abnormal SEPs were further evaluated by magnetic resonance imaging (MRI). Twenty-two patients were studied. The mean age was 64.7 years (age range: 56-81 years). Clinically, sensory impairments were found in 4 patients. Upper limb SEPs were normal. Lower limb SEPs were abnormal in 10 patients. In 1 patient, clinical and electrographic findings correlated with a patch of atrophy in the spinal cord, as shown by MRI. Sensory derangements may be found in a proportion of aging polio survivors. SEP studies may add sensitivity when evaluating sensory function in this cohort. It remains unclear whether these sensory abnormalities are related to remote poliomyelitis. Further studies are necessary.

Guidance, navigation, and control study for a solar electric propulsion spacecraft

NASA Technical Reports Server (NTRS)

Kluever, Craig A.

1995-01-01

A preliminary investigation of a lunar-comet rendezvous mission using a solar electric propulsion (SEP) spacecraft was performed in two phases.The first phase involved exploration of the moon and the second involved rendezvous with a comet. The initial phase began with a chemical propulsion translunar injection and chemical insertion into a lunar orbit, followed by a low thrust SEP transfer to a circular, polar, low-lunar orbit. After collecting scientific data at the moon, the SEP spacecraft performed a spiral lunar escape maneuver to begin the interplanetary leg of the mission. After escape from the Earth-moon system, the SEP spacecraft maneuvered in interplanetary space and performed a rendezvous with a comet.The immediate goal of this study was to demonstrate the feasibility of using a low-thrust SEP spacecraft for orbit transfer to both the moon and a comet. Another primary goal was to develop a computer optimization code which would be robust enough to obtain minimum-fuel rendezvous trajectories for a wide range of comets.

Power Systems Evaluated for Solar Electric Propulsion Vehicles

NASA Technical Reports Server (NTRS)

Kerslake, Thomas W.; Gefert, Leon P.

2000-01-01

Solar electric propulsion (SEP) mission architectures are applicable to a wide range NASA missions including the robotic exploration of the outer planets in the next decade and the human exploration of Mars within the next 2 decades. SEP enables architectures that are very mass efficient with reasonable power levels (1-MW class) aerobrake and cryogenic upper-stage transportation technologies are utilized. In this architecture, the efficient SEP stage transfers the payload from low Earth orbit (LEO) High Energy Elliptical Parking Orbit (HEEPO) within a period of 6 to 12 months. highthrust, cryogenic upper stage and payload then separate from the SEP vehicle for injection to the planetary target, allowing for fast heliocentric trip times. This mission architecture offers a potential reduction in mass to LEO in comparison to alternative all-chemical nuclear propulsion schemes. Mass reductions may allow launch vehicle downsizing enable missions that would have been grounded because of cost constraints. The preceding figure illustrates a conceptual SEP stage design for a human Mars mission. Researchers at the NASA Glenn Research Center at Lewis Field designed conceptual SEP vehicle, conceived the mission architecture to use this vehicle, and analyzed the vehicle s performance. This SEP stage has a dry mass of 35 metric tons (MT), 40 MT of xenon propellant, and a photovoltaic array that spans 110 m, providing power to a cluster of eight 100-kW Hall thrusters. The stage can transfer an 80-MT payload and upper stage to the desired HEEPO. Preliminary packaging studies show this space-station-class SEP vehicle meets the proposed "Magnum" launch vehicle and volume requirements with considerable margin. An SEP vehicle for outer planetary missions, such as the Europa Mapper Mission, would be dramatically smaller than human Mars mission SEP stage. In this mission architecture, the SEP power system with the payload to provide spacecraft power throughout the mission. Several photovoltaic array design concepts were considered for the SEP vehicle power system for the human mission to Mars. These include a space station derivative, a SCARLET (Solar Concentrator Arrays with Refractive Linear Element Technology) derivative, and a hybrid inflatable-deployable thin polymer membrane array with thin-film solar cells (as shown in the concept illustration). This concept is based on a design developed for the Next Generation Space Telescope Sun shield. The array is divided into 16 independent electrical sections with 500-V, negative-grounded solar cell strings. The power system employs a channelized, 500-Vdc power management and distribution (PMAD) architecture with lithium ion batteries for energy storage for vehicle and payload secondary loads (the high-power Hall thrusters do not operate in eclipse periods). The 500-V PMAD voltage permits "direct-drive" thruster operation, greatly reducing the power processing unit size, complexity, and power loss. Similar power system architecture, designs, and technology are assumed for the Europa Mapper Mission SEP vehicle. The primary exceptions are that the photovoltaic array is assumed to consist of two rectangular wings and that the power system rating is 15 kW in Earth orbit and 200 W at Europa. To size the SEP vehicle power system, a dedicated Fortran code was developed to predict detailed power system performance, mass, and thermal control requirements. This code also modeled all the relevant Earth orbit environments; that is, the particulate radiation, plasma, meteoroids and debris, ultraviolet radiation, contamination, and thermal conditions. Analysis results for the Human Mars Mission SEP vehicle show a power system mass of 9-MT and photovoltaic array area of 5800-square meters for the thin-membrane design concept with CuInS2 thin-film cells. Power processing unit input power for a thin-membrane array design with three-junction, amorphous SiGe solar cells is shown in the graph. Power falls off rapidly inhe first weeks of the mission because of light-induced (Staebler-Wronksi) solar cell losses. During the next 200 days, power decreases steadily as the SEP stage spirals through the proton belts and sustains the bulk of the mission radiation damage. Once the vehicle apogee is above approximately four Earth radii, little additional degradation is incurred. From 400 to 800 days, a 1100-km "parking" orbit is maintained to await the next payload transfer opportunity. This orbit is below the main proton belt, and thus, little radiation dose is accumulated during this time period. During the second LEO-to-HEEPO transfer, power degrades somewhat further, but power requirements are still met. In comparison, the Europa Mapper SEP vehicle power system had a mass of 150 kg and a thin membrane array area of 100 square meters.

SEP-Kr and SEP-Xe in Lunar Ilmenite and the Ar/Kr/Xe Ratio in the Solar Wind

NASA Astrophysics Data System (ADS)

Wieler, R.; Baur, H.; Signer, P.

1992-07-01

We analyzed all five noble gases in an ilmenite sample from lunar soil 71501 by closed system stepped etching (CSSE), thus extending our CSSE studies of solar noble gases (Wieler et al., 1986; Benkert et al., 1988) to Kr and Xe. He, Ne, Ar isotopes: We observe the familiar presence of two solar noble gas components: step 1 shows ^4He/^3He = 2250, ^20Ne/^22Ne = 13.8, and ^36Ar/^38Ar=5.46. The first two ratios are essentially identical to modern solar wind values (SWC; Geiss, 1973), indicating an isotopically unfractionated SW noble gas reservoir in lunar ilmenite. The Ne data-points of later steps fall on a straight line and reach the SEP-Ne point (^20Ne/^22Ne = 11.3). The slope of this line indicates mass dependent fractionation between SW-Ne and SEP-Ne. SEP-He (^4He/^3He = 4650 +-100) and SEP-Ar (^36Ar/^38Ar = 4.89+-0.05) are also observed (latter two numbers slightly revised compared to Wieler et al., 1992). Kr, Xe isotopes: Kr in those two steps that release pure SW-Ne is very slightly lighter than atmospheric Kr (^86Kr/^84Kr = 0.3041; see also Wieler et al., 1992). We interpret this to be SW-Kr in soil 71501. Steps containing (isotopically heavier) SEP-Ne likewise release heavier Kr, interpreted accordingly as SEP-Kr (^86Kr/^84Kr = 0.323). Similarly, a light Xe component is released first (SW-Xe, ^136Xe/^132Xe = 0.3003), followed by heavier SEP-Xe (^136Xe/^132Xe = 0.319). The data are consistent with both Kr and Xe in SW and SEP components to be related by mass fractionation. The relation first proposed by Benkert et al. (1988) between a ratio R(m(sub)2,m(sub)1) of two isotopes with masses m(sub)2>m(sub)1 in SW and SEP now holds for all five noble gases: (R(sub)SW-R(sub)SEP)/R(sub)SW = (2+-0.13)*(m(sub)2- m(sub)1)/m(sub)2. Since m(sub)2~m(sub)1, this relation may also be written as: R(sub)SEP/R(sub)SW ~ (m(sub)1/m(sub)2)^2 (Geiss and Bochsler, 1991). Element ratios: ^4He/^36Ar and ^20Ne/^36Ar rise from values several times below SWC to essentially SWC ratios in the steps releasing nearly pure SEP gases, indicating element fractionation between SW-He/Ne, but essentially unfractionated SEP-He/Ne/Ar in lunar ilmenite. In contrast, Kr/Xe stays virtually constant (^84Kr/^132Xe = 8.4+-0.5), except in the first few steps. If the light three noble gases indeed are not fractionated in the SEP dominated steps, we would also expect no fractionation for Kr/Xe. The measured ^84Kr/^132Xe ratio is, however, about 2.4 times lower than the most recent "solar system" ratio (Anders and Grevesse, 1989), albeit only ~30% lower than the "solar" value preferred by Marti and Suess (1988). Kr/Xe ratios similar to those in ilmenites have been found earlier, e.g. in Peysanoe (Marti, 1969). They are often taken to indicate fractionated loss of solar noble gases. Based on the new CSSE results, we propose, instead, that lunar ilmenites retain a faithful record of ^84Kr/^132Xe in SW and SEP (and also ^36Ar/^84Kr(sub)SW = 1750+- 300). If so, this may indicate noble gas fractionation in the solar corpuscular radiation, perhaps depending on first ionization potential or a related parameter. Work supported by the Swiss National Science Foundation. References: Anders, E. and Grevesse, N. (1989) Geochim. Cosmochim. Acta. 53, 197-214. Benkert, J.-P. et al. (1988) Lunar Planet. Sci. (abstract) 19, 59-60. Geiss, J. (1973) Proc. 13th Int. Cosmic Ray Conf. 3375-3398. Geiss, J. and Bochsler, P. (1991) In The Sun in Time (eds. C. P. Sonett, M. S. Giampapa and M.S. Matthews), pp. 98-117. Univ. Arizona Press, Tucson, Arizona. Marti, K. (1969) Science. 166. 1263-1265. Marti, K. and Suess, H. E. (1988) Astrophys. Space Sci. 144. 507-517. Wieler, R. et al. (1986) Geochim. Cosmochim. Acta. 50. 1997-2017. Wieler, R. et al. (1992) Lunar Planet. Sci. (abstract) 23.

JPRS Report, Arms Control

DTIC Science & Technology

1989-10-04

General Trading , Sharjah, which, in turn, apparently sold the chemical to M/s Rhcinscn chemical products GnbH, Düsseldorf, West Germany. He said Transpek...Situation 30 Sep-2 Oct [Prague Radio 29 Sep] 2 Tank Dismantling Begins in North Moravia [CTK 28 Sep] 2 Jackson Hole Meetings ’Very Productive ’ [J...13 Missile Project Consortium [THE TELEGRAPH 10 Jim] 14 Production of Missile Devices [S. Srinivasan; THE TELEGRAPH 14 Jim] 15

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Science.gov Websites

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Solitary extramedullary plasmacytoma of the bladder: a case report and literature.

PubMed

Khaliq, Waseem; Uzoaru, Ikechukwu; Konchanin, Ronald P; Sapiente, Ronald A; Egner, James R

2010-08-01

Plasmacytoma is a rare B-lymphocyte neoplastic disorder that usually presents as the generalized disease multiple myeloma. Less than 5% of the cases present as a solitary mass of monoclonal plasma cells in the bone or soft tissue. Although solitary extramedullary plasmacytoma (SEP) may arise in any organ, it rarely involves the urinary bladder. A 67-year-old male without a history of multiple myeloma presented with urinary frequency and nocturia; he was later diagnosed with SEP of the bladder. The patient was initially treated with a course of radiation therapy without symptomatic improvement; therefore a chemotherapy regimen consisting of lenalidomide and dexamethasone was subsequently given for six cycles. SEP usually carries a better prognosis and higher cure rate than solitary plasmacytoma of bone, as SEP is radiation sensitive. The role of adjuvant chemotherapy in the treatment of SEP that is resistant to radiation therapy is not clear, since most of the recommendations have been derived from the experience of head and neck SEP. The literature also lacks recommendations for choice of a chemotherapy regimen and surveillance of isolated bladder plasmacytoma. Here we present the first case of a radiation-resistant solitary plasmacytoma of the bladder that was successfully treated with lenalidomide and dexamethasone with successful clinical remission.

Insights into Metal Oxide and Zero-Valent Metal Nanocrystal Formation on Multiwalled Carbon Nanotube Surfaces during Sol-Gel Process.

PubMed

Das, Dipesh; Sabaraya, Indu V; Sabo-Attwood, Tara; Saleh, Navid B

2018-06-05

Carbon nanotubes are hybridized with metal crystals to impart multifunctionality into the nanohybrids (NHs). Simple but effective synthesis techniques are desired to form both zero-valent and oxides of different metal species on carbon nanotube surfaces. Sol-gel technique brings in significant advantages and is a viable technique for such synthesis. This study probes the efficacy of sol-gel process and aims to identify underlying mechanisms of crystal formation. Standard electron potential (SEP) is used as a guiding parameter to choose the metal species; i.e., highly negative SEP (e.g., Zn) with oxide crystal tendency, highly positive SEP (e.g., Ag) with zero-valent crystal-tendency, and intermediate range SEP (e.g., Cu) to probe the oxidation tendency in crystal formation are chosen. Transmission electron microscopy and X-ray diffraction are used to evaluate the synthesized NHs. Results indicate that SEP can be a reliable guide for the resulting crystalline phase of a certain metal species, particularly when the magnitude of this parameter is relatively high. However, for intermediate range SEP-metals, mix phase crystals can be expected. For example, Cu will form Cu₂O and zero-valent Cu crystals, unless the synthesis is performed in a reducing environment.

Preparation and characterization of selenite substituted hydroxyapatite.

PubMed

Ma, Jun; Wang, Yanhua; Zhou, Lei; Zhang, Shengmin

2013-01-01

Selenite-substituted hydroxyapatite (Se-HA) with different Se/P ratios was synthesized by a co-precipitation method, using sodium selenite (Na2SeO3) as a Se source. Selenium has been incorporated into the hydroxyapatite lattice by partially replacing phosphate (PO4(3-)) groups with selenite (SeO3(2-)) groups. X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR), and transmission electron microscopy (TEM) techniques reveal that substitutions of phosphate groups by selenite groups cause lower carbonate groups occupying at phosphate sites and change the lattice parameters of hydroxyapatite. The powders obtained are nano-crystalline hydroxyapatite when the Se/P ratios are not more than 0.1. The particle shape of Se-HA has not been altered compared with selenite-free hydroxyapatite but Se-incorporation reduces the crystallite size. The crystallinity was reduced as the Se/P ratios increased until amorphous phase (Se/P=0.3) appeared in the Se-HA powder obtained, and then another crystal phase presented as calcium selenite hydrate (Se/P=10). In addition, the sintering tests show that the Se-HA powders with the Se/P ratio of 0.1 have thermal stability at 900 °C for 2 h; hence they have great potential in the fabrication of bone repair scaffolds. Copyright © 2012 Elsevier B.V. All rights reserved.

Association of 3He-rich solar energetic particles with large-scale coronal waves

NASA Astrophysics Data System (ADS)

Bucik, Radoslav; Innes, Davina; Guo, Lijia; Mason, Glenn M.; Wiedenbeck, Mark

2016-07-01

Impulsive or 3He-rich solar energetic particle (SEP) events have been typically associated with jets or small EUV brightenings. We identify 30 impulsive SEP events from ACE at L1 during the solar minimum period 2007-2010 and examine their solar sources with high resolution STEREO-A EUV images. At beginning of 2007, STEREO-A was near the Earth while at the end of the investigated period, when there were more events, STEREO-A was leading the Earth by 90°. Thus STEREO-A provided a better (more direct) view on 3He-rich flares generally located on the western Sun's hemisphere. Surprisingly, we find that about half of the events are associated with large-scale EUV coronal waves. This finding provides new insights on acceleration and transport of 3He-rich SEPs in solar corona. It is believed that elemental and isotopic fractionation in impulsive SEP events is caused by more localized processes operating in the flare sites. The EUV waves have been reported in gradual SEP events in association with fast coronal mass ejections. To examine their role on 3He-rich SEPs production the energy spectra and relative abundances are discussed. R. Bucik is supported by the Deutsche Forschungsgemeinschaft under grant BU 3115/2-1.

Optimal refraction with monofocal intraocular lenses: no beneficial effect of astigmatism.

PubMed

Naeser, Kristian; Hjortdal, Jesper

2011-03-01

This study aimed to determine the optimal spherocylindrical refraction in the monofocal, pseudophakic eye using power vectors in dioptric space. For parallel incident light the defocus of a spherocylinder may be described in dioptric space as: Defocus equivalent for distance fixation = D((SEP,M,x=∞)) = √SEP(2)+(1/2M)(2), where SEP = spherical equivalent power in dioptres (D) and M = astigmatic magnitude in D. In the pseudophakic eye the defocus for any fixation distance x is: Defocus equivalent for the fixation distance x = D((SEP,M,x)) = √(SEP-1/x)(2)+ (1/2M)(2). The cumulative defocus over a fixation interval is the integral of D((SEP,M,x)) . A minimal value for cumulative defocus will indicate a maximal unaided visual acuity (VA) over the chosen fixation interval. We calculated the summated defocus for various spherocylinders for fixation distances ranging from 0.5 m to 6.0 m. Minimal cumulative defocus was present for pure spheres of -0.25 D to -0.5 D. No beneficial effect of the presence of astigmatism was detected. In monofocal pseudophakia the highest possible VAs over the most extended fixation ranges may be achieved with slight myopic refractions without astigmatic components. © 2009 The Authors. Journal compilation © 2009 Acta Ophthalmol.

Correlation of cancer incidence with diet, smoking and socio- economic position across 22 districts of Tehran in 2008.

PubMed

Rohani-Rasaf, Marzieh; Abdollahi, Morteza; Jazayeri, Shima; Kalantari, Naser; Asadi-Lari, Mohsen

2013-01-01

Variation in cancer incidence in geographical locations is due to different lifestyles and risk factors. Diet and socio-economic position (SEP) have been identified as important for the etiology of cancer but patterns are changing and inconsistent. The aim of this study was to investigate correlations of the incidence of common cancers with food groups, total energy, smoking, and SEP. In an ecological study, disaggregated cancer data through the National Cancer Registry in Iran (2008) and dietary intake, smoking habits and SEP obtained through a population based survey within the Urban Health Equity Assessment (Urban-HEART) project were correlated across 22 districts of Tehran. Consumption of fruit, meat and dairy products adjusted for energy were positively correlated with bladder, colorectal, prostate and breast and total cancers in men and women, while these cancers were adversely correlated with bread and fat intake. Also prostate, breast, colorectal, bladder and ovarian cancers had a positive correlation with SEP; there was no correlation between SEP and skin cancer in both genders and stomach cancer in men. The incidence of cancer was higher in some regions of Tehran which appeared to be mainly determined by SEP rather than dietary intake. Further individual data are required to investigate reasons of cancer clustering.

The Propitious Role of Solar Energetic Particles in the Origin of Life

NASA Astrophysics Data System (ADS)

Lingam, Manasvi; Dong, Chuanfei; Fang, Xiaohua; Jakosky, Bruce M.; Loeb, Abraham

2018-01-01

We carry out 3D numerical simulations to assess the penetration and bombardment effects of solar energetic particles (SEPs), i.e., high-energy particle bursts during large flares and superflares, on ancient and current Mars. We demonstrate that the deposition of SEPs is non-uniform at the planetary surface, and that the corresponding energy flux is lower than other sources postulated to have influenced the origin of life. Nevertheless, SEPs may have been capable of facilitating the synthesis of a wide range of vital organic molecules (e.g., nucleobases and amino acids). Owing to the relatively high efficiency of these pathways, the overall yields might be comparable to (or even exceed) the values predicted for some conventional sources such as electrical discharges and exogenous delivery by meteorites. We also suggest that SEPs could have played a role in enabling the initiation of lightning. A notable corollary of our work is that SEPs may constitute an important mechanism for prebiotic synthesis on exoplanets around M-dwarfs, thereby mitigating the deficiency of biologically active ultraviolet radiation on these planets. Although there are several uncertainties associated with (exo)planetary environments and prebiotic chemical pathways, our study illustrates that SEPs represent a potentially important factor in understanding the origin of life.

Trends in child and adolescent obesity prevalence in economically advanced countries according to socioeconomic position: a systematic review.

PubMed

Chung, A; Backholer, K; Wong, E; Palermo, C; Keating, C; Peeters, A

2016-03-01

Recent obesity trends in children and adolescents suggest a plateau. However, it is unclear whether such trends have been experienced across socioeconomic groups. We analysed whether recent trends in child and adolescent overweight and obesity differ by socioeconomic position (SEP) across economically advanced countries. Eligible studies reported overweight and obesity prevalence in children and/or adolescents (2-18 years), for at least two time points since 1990, stratified by SEP. Socioeconomic differences in trends in child and adolescent overweight and obesity over time were analysed. Differences in trends between SEP groups were observed across a majority of studies. Over half the studies indicated increasing prevalence among low SEP children and adolescents compared to a third of studies among children and adolescents with a high SEP. Around half the studies indicated widening socioeconomic inequalities in overweight and obesity. Since 2000 a majority of studies demonstrated no change or a decrease in prevalence among both high and low SEP groups. However around 40% of studies indicated widening of socioeconomic inequalities post-2000. While our study provides grounds for optimism, socioeconomic inequalities in overweight and obesity continue to widen. These findings highlight the need for greater consideration of different population groups when implementing obesity interventions. © 2015 World Obesity.

Childhood social class and adult adiposity and blood-pressure trajectories 36-53 years: gender-specific results from a British birth cohort.

PubMed

Strand, Bjørn Heine; Murray, Emily T; Guralnik, Jack; Hardy, Rebecca; Kuh, Diana

2012-06-01

In this study, the authors investigate gender-specific effects of childhood socio-economic position (SEP) on adiposity and blood pressure at three time points in adulthood. Mixed models were used to assess the association of childhood SEP with body mass index (BMI), waist circumference, systolic blood pressure (SBP) and diastolic blood pressure (DBP) at ages 36, 43 and 53 years in a British birth cohort. The adverse effect of lower childhood SEP on adiposity increased between ages 36 and 53 years in women (BMI: trend test: p=0.03) and remained stable in men, but the opposite was seen for SBP, where inequalities increased in men (p=0.01). Childhood SEP inequalities in DBP were stable with age in both men and women. Educational attainment mediated some but not all of the effects of childhood SEP on adiposity and SBP, and their rate of change; adult social class was a less important mediator. Childhood SEP is important for adult adiposity and blood pressure across midlife, especially for BMI in women and for blood pressure in men. Thus, pathways to adult health differ for men and women, and public health policies aimed at reducing social inequalities need to start early in life and take account of gender.

Socioeconomic position and cognitive function in the Seychelles: a life course analysis.

PubMed

Kobrosly, Roni W; van Wijngaarden, Edwin; Galea, Sandro; Cory-Slechta, Deborah A; Love, Tanzy; Hong, Caroline; Shamlaye, Conrad F; Davidson, Philip W

2011-01-01

Poorer socioeconomic conditions early in life have been linked with memory, attention and learning deficits in adulthood, as well as with specific areas of educational achievement. It remains unclear, however, whether these distal associations are mediated by more current socioeconomic factors. In this study, we sought to confirm the relation between early-life socioeconomic position (SEP) and adult cognitive function, and to examine potential mediation by contemporaneous SEP. Data from 463 young adults from the Main Cohort of the Seychelles Child Development Study were analyzed using subtests of the Cambridge Neurological Test Automated Battery and the Woodcock Johnson Test of Scholastic Achievement in relation to maternal Hollingshead Social Status Index scores at study enrollment (infancy), follow-up at 107 months, and follow-up at 17 years. Findings include evidence of a link between infant-period SEP and 17-year memory, which was not mediated by childhood and 17-year SEP. Verbal and mathematical achievement at 17 years was associated with SEP at all points in the life course. SEP at different points during the young-adult life course may affect different cognitive domains later in life, which may provide targets for societal investment in ensuring adequate family resources throughout childhood and adolescence. Copyright © 2011 S. Karger AG, Basel.

Socioeconomic Position and Cognitive Function in the Seychelles: A Life Course Analysis

PubMed Central

Kobrosly, Roni W.; van Wijngaarden, Edwin; Galea, Sandro; Cory-Slechta, Deborah A.; Love, Tanzy; Hong, Caroline; Shamlaye, Conrad F.; Davidson, Philip W.

2011-01-01

Objective Poorer socioeconomic conditions early in life have been linked with memory, attention and learning deficits in adulthood, as well as with specific areas of educational achievement. It remains unclear, however, whether these distal associations are mediated by more current socioeconomic factors. In this study, we sought to confirm the relation between early-life socioeconomic position (SEP) and adult cognitive function, and to examine potential mediation by contemporaneous SEP. Methods Data from 463 young adults from the Main Cohort of the Seychelles Child Development Study were analyzed using subtests of the Cambridge Neurological Test Automated Battery and the Woodcock Johnson Test of Scholastic Achievement in relation to maternal Hollingshead Social Status Index scores at study enrollment (infancy), follow-up at 107 months, and follow-up at 17 years. Results Findings include evidence of a link between infant-period SEP and 17-year memory, which was not mediated by childhood and 17-year SEP. Verbal and mathematical achievement at 17 years was associated with SEP at all points in the life course. Conclusions SEP at different points during the young-adult life course may affect different cognitive domains later in life, which may provide targets for societal investment in ensuring adequate family resources throughout childhood and adolescence. PMID:21508650

A novel serine protease, Sep1, from Bacillus firmus DS-1 has nematicidal activity and degrades multiple intestinal-associated nematode proteins.

PubMed

Geng, Ce; Nie, Xiangtao; Tang, Zhichao; Zhang, Yuyang; Lin, Jian; Sun, Ming; Peng, Donghai

2016-04-27

Plant-parasitic nematodes (PPNs) cause serious harm to agricultural production. Bacillus firmus shows excellent control of PPNs and has been produced as a commercial nematicide. However, its nematicidal factors and mechanisms are still unknown. In this study, we showed that B. firmus strain DS-1 has high toxicity against Meloidogyne incognita and soybean cyst nematode. We sequenced the whole genome of DS-1 and identified multiple potential virulence factors. We then focused on a peptidase S8 superfamily protein called Sep1 and demonstrated that it had toxicity against the nematodes Caenorhabditis elegans and M. incognita. The Sep1 protein exhibited serine protease activity and degraded the intestinal tissues of nematodes. Thus, the Sep1 protease of B. firmus is a novel biocontrol factor with activity against a root-knot nematode. We then used C. elegans as a model to elucidate the nematicidal mechanism of Sep1, and the results showed that Sep1 could degrade multiple intestinal and cuticle-associated proteins and destroyed host physical barriers. The knowledge gained in our study will lead to a better understanding of the mechanisms of B. firmus against PPNs and will aid in the development of novel bio-agents with increased efficacy for controlling PPNs.

Formulation optimization of aprepitant microemulsion-loaded silicated corn fiber gum particles for enhanced bioavailability.

PubMed

Kamboj, Sunil; Rana, Vikas

2016-08-01

The present investigation was aimed at development of silicate corn fiber gum (SCFG) particles as superior solid carrier for the preparation of Aprepitant (APT)-loaded self-emulsifying powder (SEP) system. 2(4) D-optimal mixture design with three level process variables was employed to develop SCFG particles, utilizing flow descriptors and hydrophobicity descriptors as response variables. The results indicated that blending of CFG (51.4% w/w) and magnesium silicate (MS) (48.6% w/w) using freeze-drying technique was found to have highest desirability (0.904). The developed SEP showed highest oil desorbing capacity, low self-emulsification time and highest drug content. It was observed that SCFG-SEP (F2 formulation) showed lowest PDI (0.2445 ± 0.03) as well as smallest particle size (127 ± 5.8 nm). The droplets were uniform and maintain their integrity after reconstitution (TEM analysis). Furthermore, APT-loaded SEP showed enhanced in vitro dissolution (4 folds) and ex vivo performance (7-fold enhanced Papp) as compared to pure APT. Furthermore, in vivo pharmacokinetic study showed that significant enhancement (p > 0.05) in Cmax was evident with APT-loaded F2 (SCFG-SEP) (1.93-fold) and F4 (Aerosil 200-SEP) (1.58-fold). The data also suggested increase in absorption rate when APT incorporated into SCFG-SEP. Thus, findings pointed toward enhanced bioavailability of APT when loaded into SCFG particles. Overall, the developed SCFG particles could be considered as a better alternative to already available solid carrier(s).

Solar Energetic Particle Variations

NASA Technical Reports Server (NTRS)

Reames, D. V.

2003-01-01

In the largest solar energetic-particle (SEP) events, acceleration occurs at shock waves driven out from the Sun by coronal mass ejections (CMEs). In fact, the highest proton intensities directly measured near Earth at energies up to approximately 1 GeV occur at the time of passage of shocks, which arrive about a day after the CMEs leave the Sun. CME-driven shocks expanding across magnetic fields can fill over half of the heliosphere with SEPs. Proton-generated Alfven waves trap particles near the shock for efficient acceleration but also throttle the intensities at Earth to the streaming limit early in the events. At high energies, particles begin to leak from the shock and the spectrum rolls downward to form an energy-spectral 'knee' that can vary in energy from approximately 1 MeV to approximately 1 GeV in different events. All of these factors affect the radiation dose as a function of depth and latitude in the Earth's atmosphere and the risk to astronauts and equipment in space. SEP ionization of the polar atmosphere produces nitrates that precipitate to become trapped in the polar ice. Observations of nitrate deposits in ice cores reveal individual large SEP events and extend back approximately 400 years. Unlike sunspots, SEP events follow the approximately 80-100-year Gleissberg cycle rather faithfully and are now at a minimum in that cycle. The largest SEP event in the last 400 years appears to be related to the flare observed by Carrington in 1859, but the probability of SEP events with such large fluences falls off sharply because of the streaming limit.

LEO to GEO (and Beyond) Transfers Using High Power Solar Electric Propulsion (HP-SEP)

NASA Technical Reports Server (NTRS)

Loghry, Christopher S.; Oleson, Steven R.; Woytach, Jeffrey M.; Martini, Michael C.; Smith, David A.; Fittje, James E.; Gyekenyesi, John Z.; Colozza, Anthony J.; Fincannon, James; Bogner, Aimee;

A Hierarchical Relationship Between the Fluence Spectra and CME Kinematics in Large Solar Energetic Particle Events: A Radio Perspective

NASA Technical Reports Server (NTRS)

Gopalswamy, N.; Makela, P.; Yashiro, S.; Thakur, N.; Akiyama, S.; Xie, H.

2017-01-01

We report on further evidence that solar energetic particles are organized by the kinematic properties of coronal mass ejections (CMEs). In particular, we focus on the starting frequency of type II bursts, which is related to the distance from the Sun where the radio emission starts. We find that the three groups of solar energetic particle (SEP) events known to have distinct values of CME initial acceleration, also have distinct average starting frequencies of the associated type II bursts. SEP events with ground level enhancement (GLE) have the highest starting frequency (107 MHz), while those associated with filament eruption (FE) in quiescent regions have the lowest starting frequency (22 MHz); regular SEP events have intermediate starting frequency (81 MHz). Taking the onset time of type II bursts as the time of shock formation, we determine the shock formation heights measured from the Sun center. We find that the shocks form on average closest to the Sun (1.51 Rs) in GLE events, farthest from the Sun in FE SEP events (5.38 Rs), and at intermediate distances in regular SEP events (1.72 Rs). Finally, we present the results of a case study of a CME with high initial acceleration (approx. 3 km s-2) and a type II radio burst with high starting frequency (200 MHz) but associated with a minor SEP event. We find that the relation between the fluence spectral index and CME initial acceleration continues to hold even for this minor SEP event.

A Hierarchical Relationship Between the Fluence Spectra and CME Kinematics in Large Solar Energetic Particle Events: A Radio Perspective

NASA Technical Reports Server (NTRS)

Gopalswamy, N.; Makela, P.; Yashiro, S.; Thakur, N.; Akiyama, S.; Xie, H.

2017-01-01

We report on further evidence that solar energetic particles are organized by the kinematic properties of coronal mass ejections (CMEs). In particular, we focus on the starting frequency of type II bursts, which is related to the distance from the Sun where the radio emission starts. We find that the three groups of solar energetic particle (SEP) events known to have distinct values of CME initial acceleration, also have distinct average starting frequencies of the associated type II bursts. SEP events with ground level enhancement (GLE) have the highest starting frequency (107 MHz), while those associated with filament eruption (FE) in quiescent regions have the lowest starting frequency (22 MHz); regular SEP events have intermediate starting frequency (81 MHz). Taking the onset time of type II bursts as the time of shock formation, we determine the shock formation heights measured from the Sun center. We find that the shocks form on average closest to the Sun (1.51 Rs) in GLE events, farthest from the Sun in FE SEP events (5.38 Rs), and at intermediate distances in regular SEP events (1.72 Rs). Finally, we present the results of a case study of a CME with high initial acceleration (approx.3 km s-2) and a type II radio burst with high starting frequency (approx. 200 MHz) but associated with a minor SEP event. We find that the relation between the fluence spectral index and CME initial acceleration continues to hold even for this minor SEP event.

On the use of information theory for the analysis of synchronous nociceptive withdrawal reflexes and somatosensory evoked potentials elicited by graded electrical stimulation.

PubMed

Arguissain, Federico G; Biurrun Manresa, José A; Mørch, Carsten D; Andersen, Ole K

2015-01-30

To date, few studies have combined the simultaneous acquisition of nociceptive withdrawal reflexes (NWR) and somatosensory evoked potentials (SEPs). In fact, it is unknown whether the combination of these two signals acquired simultaneously could provide additional information on somatosensory processing at spinal and supraspinal level compared to individual NWR and SEP signals. By using the concept of mutual information (MI), it is possible to quantify the relation between electrical stimuli and simultaneous elicited electrophysiological responses in humans based on the estimated stimulus-response signal probability distributions. All selected features from NWR and SEPs were informative in regard to the stimulus when considered individually. Specifically, the information carried by NWR features was significantly higher than the information contained in the SEP features (p<0.05). Moreover, the joint information carried by the combination of features showed an overall redundancy compared to the sum of the individual contributions. Comparison with existing methods MI can be used to quantify the information that single-trial NWR and SEP features convey, as well as the information carried jointly by NWR and SEPs. This is a model-free approach that considers linear and non-linear correlations at any order and is not constrained by parametric assumptions. The current study introduces a novel approach that allows the quantification of the individual and joint information content of single-trial NWR and SEP features. This methodology could be used to decode and interpret spinal and supraspinal interaction in studies modulating the responsiveness of the nociceptive system. Copyright © 2014 Elsevier B.V. All rights reserved.

Association of Impulsive Solar Energetic Particle Events With Large-Scale Coronal Waves

NASA Astrophysics Data System (ADS)

Bucik, R.; Innes, D.; Mason, G. M.; Wiedenbeck, M. E.

2016-12-01

Impulsive or 3He-rich solar energetic particle (SEP) events have been commonly associated with EUV jets and narrow CMEs which are believed to be the signatures of magnetic reconnection involving field lines open to interplanetary space. The elemental and isotopic fractionation in these events are thought to be caused by processes confined to the flare sites. In addition to their anomalous abundances, 3He-rich SEPs show puzzling energy spectral shapes varying from rounded forms to power laws where the later are characteristics of shock acceleration. In this study we identify 32 impulsive SEP events observed by the ACE near the Earth during the solar minimum period 2007-2010 and examine their solar sources with the high resolution STEREO EUV images. Leading the Earth, STEREO-A provided for the first time a direct view on impulsive SEP event sources, which are generally located on the Sun's western hemisphere. Surprisingly, we find that about half of the impulsive SEP events in this survey are associated with large-scale EUV coronal waves. An examination of the wave front propagation and the coronal magnetic field connections suggests that the EUV waves may affect the injection of 3He-rich SEPs into interplanetary space. We found the events with jets tend to be associated with rounded spectra and the events with coronal waves with power laws. This suggests that coronal waves may be related to the unknown second stage mechanism commonly used to interpret spectral forms of 3He-rich SEPs. R. Bucik is supported by the Deutsche Forschungsgemeinschaft under grant BU 3115/2-1.

Simultaneous determination of dextrose, sucrose, maltose, and lactose in sausage products by liquid chromatography.

PubMed

Ali, M S

1988-01-01

A liquid chromatographic (LC) method for the simultaneous determination of dextrose, sucrose, maltose, and lactose in sausage products has been developed. Dextrose, sucrose, maltose, and lactose are extracted from comminuted meat products with 52% ethanol. After filtration, the extracts are purified by passing them through a C18 Sep-Pak cartridge and 2 ion exchange resin Econo-columns in series. After concentration and filtration, extracts are analyzed by LC using a normal phase amino column and a differential refractometer detector. Homogeneously ground samples of cooked and fresh sausages are fortified with dextrose, sucrose, maltose, and lactose at 4 different concentrations. Average recovery for dextrose, sucrose, maltose, and lactose at all 4 levels of fortification was greater than 80% with a coefficient of variation less than 10%.

Early impairment of somatosensory evoked potentials in very young children with achondroplasia with foramen magnum stenosis.

PubMed

Fornarino, Stefania; Rossi, Daniela Paola; Severino, Mariasavina; Pistorio, Angela; Allegri, Anna Elsa Maria; Martelli, Simona; Doria Lamba, Laura; Lanteri, Paola

2017-02-01

To evaluate the contribution of somatosensory evoked potentials after median nerve (MN-SEPs) and posterior tibial nerve (PTN-SEPs) stimulation in functional assessment of cervical and lumbar spinal stenosis in children with achondroplasia. We reviewed MN-SEPs, PTN-SEPs, and spinal magnetic resonance imaging (MRI) examinations performed in 58 patients with achondroplasia (25 males, 33 females; age range 21d-16y 10mo; mean age 4y 3mo [SD 4y 1mo]). Patients were subdivided into four age categories: <2 years, between 2 to 4 years, between 4 to 8 years, and ≥8 years. The peak latency of P37 for PTN-SEPs, the peak latencies of N11, N13, P14, and N20, and the N13-N20 interpeak latency (IPL) for MN-SEPs were collected; the diagnostic accuracy measures of these parameters (analysis of receiver operating characteristic [ROC] curves) with respect to the presence of foramen magnum or lumbar spinal stenosis were analysed in each age category. The ROC curve analysis showed that the most sensitive parameter in detecting the presence of foramen magnum stenosis was P37 latency in the first two age categories (<2y and ≥2-4y; sensitivity 0.63, specificity 1.00, and sensitivity 1.00, specificity 0.75 respectively). In the third age category (≥4-8y), the most sensitive parameter in detecting the presence of foramen magnum stenosis was IPLs N13-N20 (sensitivity 0.73, specificity 0.87), whereas in the last age category (≥8y), the most important parameter was N20 latency (sensitivity 0.75, specificity 0.77). In children with achondroplasia, the cortical component of PTN-SEPs is more sensitive than the cortical component and central conduction time of MN-SEPs in detection of cervical spinal cord compression at early ages. © 2016 Mac Keith Press.

Socioeconomic disparities in lung cancer mortality in Belgian men and women (2001-2011): does it matter who you live with?

PubMed

Vanthomme, Katrien; Vandenheede, Hadewijch; Hagedoorn, Paulien; Gadeyne, Sylvie

2016-06-10

Ample studies have observed an adverse association between individual socioeconomic position (SEP) and lung cancer mortality. Moreover, the presence of a partner has shown to be a crucial determinant of health. Yet, few studies have assessed whether partner's SEP affects health in addition to individual SEP. This paper will study whether own SEP (education), partner's SEP (partner's education) and own and partner's SEP combined (housing conditions), are associated with lung cancer mortality in Belgium. Data consist of the Belgian 2001 census linked to register data on cause-specific mortality for 2001-2011. The study population includes all married or cohabiting Belgian inhabitants aged 40-84 years. Age-standardized lung cancer mortality rates (direct standardization) and mortality rate ratios (Poisson regression) were computed for the different SEP groups. In men, we observed a clear inverse association between all SEP indicators (own and partner's education, and housing conditions) and lung cancer mortality. Men benefit from having a higher educated partner in terms of lower lung cancer mortality rates. These observations hold for both middle-aged and older men. For women, the picture is less uniform. In middle-aged and older women, housing conditions is inversely associated with lung cancer mortality. As for partner's education, for middle-aged women, the association is rather weak whereas for older women, there is no such association. Whereas the educational level of middle-aged women is inversely associated with lung cancer mortality, in older women this association disappears in the fully adjusted model. Both men and women benefit from being in a relationship with a high-educated partner. It seems that for men, the educational level of their partner is of great importance while for women the housing conditions is more substantial. Both research and policy interventions should allow for the family level as well.

Young adults' medicine use for headache: the combined effect of socioeconomic position and perceived stress, and the contribution of sense of coherence.

PubMed

Koushede, Vibeke; Hansen, Ebba Holme; Andersen, Anette; Holstein, Bjørn E

2012-01-01

Over-the-counter analgesic (OTCA) use is increasingly common and may have potential harmful side effects. The primary reason for using analgesics is headache symptoms. Whether OTCA use for headache is sensitive to psychosocial and social circumstances is an understudied topic. The purpose of this study was to examine the combined effect of socioeconomic position (SEP) and perceived stress on OTCA use for headache. An additional objective was to determine whether sense of coherence (SOC) modifies the association. Data derived from the cross-sectional "Danish Lifestyle and Medicine Use Study," 2009. The study population consisted of men and women ages 25-44 years (n = 955). The dependent variable was OTCA use for headache within the past 14 days. The independent variables were SEP, perceived stress, and SOC. Gender, headache prevalence, and response method were included as covariates. Associations were examined by means of logistic regression analyses, and reported as odds ratios (ORs) with 95% confidence intervals. The OR for OTCA use was 1.42 (0.94-2.14) (statistically nonsignificant) among participants with low SEP but no perceived stress (reference high SEP, no perceived stress), 2.09 (1.53-2.85) for participants with perceived stress and high SEP, and 2.65 (1.66-4.25) among participants with perceived stress and low SEP. In analysis, stratified by SOC associations were stronger among participants with low SOC than among those with high SOC. Individuals exposed to both low SEP and high perceived stress have high odds for using OTCA for headache, apparently higher than participants only exposed to 1 of these factors. SOC may act as a buffer against the harmful effects of perceived stress and low SEP on OTCA use. Health care professionals and policymakers need to be aware of the sensitivity of OTCA use to psychosocial and social circumstances. Copyright © 2012 Elsevier Inc. All rights reserved.

The impact of a tax on sugar-sweetened beverages according to socio-economic position: a systematic review of the evidence.

PubMed

Backholer, Kathryn; Sarink, Danja; Beauchamp, Alison; Keating, Catherine; Loh, Venurs; Ball, Kylie; Martin, Jane; Peeters, Anna

2016-12-01

A tax on sugar-sweetened beverages (SSB) has been proposed to address population weight gain but the effect across socio-economic position (SEP) is unclear. The current study aimed to clarify the differential impact(s) of SSB taxes on beverage purchases and consumption, weight outcomes and the amount paid in SSB taxes according to SEP. Databases (OVID and EMBASE) and grey literature were systematically searched in June 2015 to identify studies that examined effects of an SSB price increase on beverage purchases or consumption, weight outcomes or the amount paid in tax across SEP, within high-income countries. Of the eleven included articles, three study types were identified: (i) those that examined the association between variation in SSB taxes and SSB consumption and/or body weight (n 3); (ii) price elasticity estimation of SSB demand (n 1); and (iii) modelling of hypothetical SSB taxes by combining price elasticity estimates with population SEP-specific beverage consumption, energy intake or body weight (n 7). Few studies statistically tested differences in outcomes between SEP groups. Nevertheless, of the seven studies that reported on changes in weight outcomes for the total population following an increase in SSB price, all reported either similar reductions in weight across SEP groups or greater reductions for lower compared with higher SEP groups. All studies that examined the average household amount paid in tax (n 5) reported that an SSB tax would be regressive, but with small differences between higher- and lower-income households (0·10-1·0 % and 0·03 %-0·60 % of annual household income paid in SSB tax for low- and high-income households, respectively). Based on the available evidence, a tax on SSB will deliver similar population weight benefits across socio-economic strata or greater benefits for lower SEP groups. An SSB tax is shown to be consistently financially regressive, but to a small degree.

Solar energetic particle transport in the heliosphere

NASA Astrophysics Data System (ADS)

Pei, Chunsheng

2007-08-01

The transport of solar energetic particles (SEPs) in the inner heliosphere is a very important issue which can affect our daily life. For example, large SEP events can lead to the failure of power grids, interrupt communications, and may participate in global climate change. The SEPS also can harm humans in space and destroy the instruments on board spacecraft. Studying the transport of SEPs also helps us understand remote regions of space which are not visible to us because there are not enough photons in those places. The interplanetary magnetic field is the medium in which solar energetic particles travel. The Parker Model of the solar wind and its successor, the Weber and Davis model, have been the dominant models of the solar wind and the interplanetary magnetic field since 1960s. In this thesis, I have reviewed these models and applied an important correction to the Weber and Davis model Various solar wind models and their limitations are presented. Different models can affect the calculation of magnetic field direction at 1 AU by as much as about 30%. Analysis of the onset of SEP events could be used to infer the release time of solar energetic particles and to differentiate between models of particle acceleration near the Sun. It is demonstrated that because of the nature of the stochastic heliospheric magnetic field, the path length measured along the line of force can be shorter than that of the nominal Parker spiral. These results help to explain recent observations. A two dimensional model and a fully three dimensional numerical model for the transport of SEPs has been developed based on Parker's transport equation for the first time. ''Reservoir'' phenomenon, which means the inner heliosphere works like a reservoir for SEPs during large SEP events, and multi-spacecraft observation of peak intensities are explained by this numerical model.

Shear bond strength and debonding characteristics of metal and ceramic brackets bonded with conventional acid-etch and self-etch primer systems: An in-vivo study.

PubMed

Mirzakouchaki, Behnam; Shirazi, Sajjad; Sharghi, Reza; Shirazi, Samaneh; Moghimi, Mahsan; Shahrbaf, Shirin

2016-02-01

Different in-vitro studies have reported various results regarding shear bond strength (SBS) of orthodontic brackets when SEP technique is compared to conventional system. This in-vivo study was designed to compare the effect of conventional acid-etching and self-etching primer adhesive (SEP) systems on SBS and debonding characteristics of metal and ceramic orthodontic brackets. 120 intact first maxillary and mandibular premolars of 30 orthodontic patients were selected and bonded with metal and ceramic brackets using conventional acid-etch or self-etch primer system. The bonded brackets were incorporated into the wire during the study period to simulate the real orthodontic treatment condition. The teeth were extracted and debonded after 30 days. The SBS, debonding characteristics and adhesive remnant indices (ARI) were determined in all groups. The mean SBS of metal brackets was 10.63±1.42 MPa in conventional and 9.38±1.53 MPa in SEP system, (P=0.004). No statistically significant difference was noted between conventional and SEP systems in ceramic brackets. The frequency of 1, 2 and 3 ARI scores and debonding within the adhesive were the most common among all groups. No statistically significant difference was observed regarding ARI or failure mode of debonded specimens in different brackets or bonding systems. The SBS of metal brackets bonded using conventional system was significantly higher than SEP system, although the SBS of SEP system was clinically acceptable. No significant difference was found between conventional and SEP systems used with ceramic brackets. Total SBS of metal brackets was significantly higher than ceramic brackets. Due to adequate SBS of SEP system in bonding the metal brackets, it can be used as an alternative for conventional system. Shear bond strength, Orthodontic brackets, Adhesive remnant index, self-etch.

Shear bond strength and debonding characteristics of metal and ceramic brackets bonded with conventional acid-etch and self-etch primer systems: An in-vivo study

PubMed Central

Mirzakouchaki, Behnam; Sharghi, Reza; Shirazi, Samaneh; Moghimi, Mahsan; Shahrbaf, Shirin

2016-01-01

Background Different in-vitro studies have reported various results regarding shear bond strength (SBS) of orthodontic brackets when SEP technique is compared to conventional system. This in-vivo study was designed to compare the effect of conventional acid-etching and self-etching primer adhesive (SEP) systems on SBS and debonding characteristics of metal and ceramic orthodontic brackets. Material and Methods 120 intact first maxillary and mandibular premolars of 30 orthodontic patients were selected and bonded with metal and ceramic brackets using conventional acid-etch or self-etch primer system. The bonded brackets were incorporated into the wire during the study period to simulate the real orthodontic treatment condition. The teeth were extracted and debonded after 30 days. The SBS, debonding characteristics and adhesive remnant indices (ARI) were determined in all groups. Results The mean SBS of metal brackets was 10.63±1.42 MPa in conventional and 9.38±1.53 MPa in SEP system, (P=0.004). No statistically significant difference was noted between conventional and SEP systems in ceramic brackets. The frequency of 1, 2 and 3 ARI scores and debonding within the adhesive were the most common among all groups. No statistically significant difference was observed regarding ARI or failure mode of debonded specimens in different brackets or bonding systems. Conclusions The SBS of metal brackets bonded using conventional system was significantly higher than SEP system, although the SBS of SEP system was clinically acceptable. No significant difference was found between conventional and SEP systems used with ceramic brackets. Total SBS of metal brackets was significantly higher than ceramic brackets. Due to adequate SBS of SEP system in bonding the metal brackets, it can be used as an alternative for conventional system. Key words:Shear bond strength, Orthodontic brackets, Adhesive remnant index, self-etch. PMID:26855704

Interactive and independent associations between the socioeconomic and objective built environment on the neighbourhood level and individual health: a systematic review of multilevel studies.

PubMed

Schüle, Steffen Andreas; Bolte, Gabriele

2015-01-01

The research question how contextual factors of neighbourhood environments influence individual health has gained increasing attention in public health research. Both socioeconomic neighbourhood characteristics and factors of the built environment play an important role for health and health-related behaviours. However, their reciprocal relationships have not been systematically reviewed so far. This systematic review aims to identify studies applying a multilevel modelling approach which consider both neighbourhood socioeconomic position (SEP) and factors of the objective built environment simultaneously in order to disentangle their independent and interactive effects on individual health. The three databases PubMed, PsycINFO, and Web of Science were systematically searched with terms for title and abstract screening. Grey literature was not included. Observational studies from USA, Canada, Australia, New Zealand, and Western European countries were considered which analysed simultaneously factors of neighbourhood SEP and the objective built environment with a multilevel modelling approach. Adjustment for individual SEP was a further inclusion criterion. Thirty-three studies were included in qualitative synthesis. Twenty-two studies showed an independent association between characteristics of neighbourhood SEP or the built environment and individual health outcomes or health-related behaviours. Twenty-one studies found cross-level or within-level interactions either between neighbourhood SEP and the built environment, or between neighbourhood SEP or the built environment and individual characteristics, such as sex, individual SEP or ethnicity. Due to the large variation of study design and heterogeneous reporting of results the identification of consistent findings was problematic and made quantitative analysis not possible. There is a need for studies considering multiple neighbourhood dimensions and applying multilevel modelling in order to clarify their causal relationship towards individual health. Especially, more studies using comparable characteristics of neighbourhood SEP and the objective built environment and analysing interactive effects are necessary to disentangle health impacts and identify vulnerable neighbourhoods and population groups.

Interactive and Independent Associations between the Socioeconomic and Objective Built Environment on the Neighbourhood Level and Individual Health: A Systematic Review of Multilevel Studies

PubMed Central

Schüle, Steffen Andreas; Bolte, Gabriele

2015-01-01

Background The research question how contextual factors of neighbourhood environments influence individual health has gained increasing attention in public health research. Both socioeconomic neighbourhood characteristics and factors of the built environment play an important role for health and health-related behaviours. However, their reciprocal relationships have not been systematically reviewed so far. This systematic review aims to identify studies applying a multilevel modelling approach which consider both neighbourhood socioeconomic position (SEP) and factors of the objective built environment simultaneously in order to disentangle their independent and interactive effects on individual health. Methods The three databases PubMed, PsycINFO, and Web of Science were systematically searched with terms for title and abstract screening. Grey literature was not included. Observational studies from USA, Canada, Australia, New Zealand, and Western European countries were considered which analysed simultaneously factors of neighbourhood SEP and the objective built environment with a multilevel modelling approach. Adjustment for individual SEP was a further inclusion criterion. Results Thirty-three studies were included in qualitative synthesis. Twenty-two studies showed an independent association between characteristics of neighbourhood SEP or the built environment and individual health outcomes or health-related behaviours. Twenty-one studies found cross-level or within-level interactions either between neighbourhood SEP and the built environment, or between neighbourhood SEP or the built environment and individual characteristics, such as sex, individual SEP or ethnicity. Due to the large variation of study design and heterogeneous reporting of results the identification of consistent findings was problematic and made quantitative analysis not possible. Conclusions There is a need for studies considering multiple neighbourhood dimensions and applying multilevel modelling in order to clarify their causal relationship towards individual health. Especially, more studies using comparable characteristics of neighbourhood SEP and the objective built environment and analysing interactive effects are necessary to disentangle health impacts and identify vulnerable neighbourhoods and population groups. PMID:25849569

ISO 50001 and SEP Faster and Cheaper - Exploring the Enterprise-Wide Approach

DOE Office of Scientific and Technical Information (OSTI.GOV)

Liu, Jingjing; Rao, Prakash; Therkelsen, Peter

ISO 50001 and other management systems (e.g., ISO 9001 and ISO 14001) allow for implementation and certification at the enterprise level. The "Central Office" concept, which allows a small group of employees to manage and facilitate the organization’s energy management system (EnMS) at the enterprise level, was introduced within the ISO 50003 standard to provide guidance to ISO 50001 certification bodies. Four industrial companies have partnered with the United States Department of Energy to pilot the enterprise-wide ISO 50001/SEP concept under the Better Buildings Superior Energy Performance (SEP) Enterprise-wide Accelerator. Each organization developed a Central Office to host their EnMSmore » while implementing ISO 50001/SEP at multiple physically separated sites. The four corporate partners tailored their Central Office implementation model to meet their own specific circumstances and needs. This paper reviews the commonalities, differences, and benefits of each of these enterprise-wide implementation models, including organizational structures, Central Office staff responsibilities, and key strategies. The cost savings and benefits of using the enterprise-wide approach were assessed, including the cost per site compared with that of a conventional, single-site ISO 50001/SEP implementation approach. This paper also discusses the drivers for the cost reductions realized through these enterprise-wide approaches. The four partner companies worked with 30 total sites. On average, these 30 sites improved energy performance by 5% annually over their SEP achievement periods, saved more than $600,000 annually in energy costs and reduced implementation cost for ISO 50001 and SEP by $19,000 and 0.8 Full Time Equivalent × years (FTE-yr) of staff time per site. The results can inform other organizations seeking to implement enterprise-wide ISO 50001/SEP, as well as energy efficiency organizations seeking to promote wider adoption of ISO 50001 implementation.« less

Socioeconomic conditions across life related to multiple measures of the endocrine system in older adults: Longitudinal findings from a British birth cohort study

PubMed Central

Bann, David; Hardy, Rebecca; Cooper, Rachel; Lashen, Hany; Keevil, Brian; Wu, Frederick C.W.; Holly, Jeff M.P.; Ong, Ken K.; Ben-Shlomo, Yoav; Kuh, Diana

2015-01-01

Background Little is known about how socioeconomic position (SEP) across life impacts on different axes of the endocrine system which are thought to underlie the ageing process and its adverse consequences. We examined how indicators of SEP across life related to multiple markers of the endocrine system in late midlife, and hypothesized that lower SEP across life would be associated with an adverse hormone profile across multiple axes. Methods Data were from a British cohort study of 875 men and 905 women followed since their birth in March 1946 with circulating free testosterone and insulin-like growth factor-I (IGF-I) measured at both 53 and 60–64 years, and evening cortisol at 60–64 years. Indicators of SEP were ascertained prospectively across life—paternal occupational class at 4, highest educational attainment at 26, household occupational class at 53, and household income at 60–64 years. Associations between SEP and hormones were investigated using multiple regression and logistic regression models. Results Lower SEP was associated with lower free testosterone among men, higher free testosterone among women, and lower IGF-I and higher evening cortisol in both sexes. For example, the mean standardised difference in IGF-I comparing the lowest with the highest educational attainment at 26 years (slope index of inequality) was −0.4 in men (95% CI -0.7 to −0.2) and −0.4 in women (−0.6 to −0.2). Associations with each hormone differed by SEP indicator used and sex, and were particularly pronounced when using a composite adverse hormone score. For example, the odds of having 1 additional adverse hormone concentration in the lowest compared with highest education level were 3.7 (95% CI: 2.1, 6.3) among men, and 1.6 (1.0, 2.7) among women (P (sex interaction) = 0.02). We found no evidence that SEP was related to apparent age-related declines in free testosterone or IGF-I. Conclusions Lower SEP was associated with an adverse hormone profile across multiple endocrine axes. SEP differences in endocrine function may partly underlie inequalities in health and function in later life, and may reflect variations in biological rates of ageing. Further studies are required to assess the likely functional relevance of these associations. PMID:26588434

22 CFR Appendix C to Part 62 - Update of Information on Exchange-Visitor Program Sponsor

Code of Federal Regulations, 2010 CFR

2010-04-01

... assigned to ________ as follows: (Name of institution/organization) 1. Change the name of the Program... Cultural Exchange. 9. ( ) Cancel the above named Exchange Visitor Program. (Signature of Responsible or...

Determinants of Participating in Australian University Student Exchange Programs

ERIC Educational Resources Information Center

Daly, Amanda

2011-01-01

Outbound mobility programs such as exchange programs are one of the many strategies implemented at universities to develop graduates' intercultural skills and international knowledge. Few Australian students participate in exchange programs. This article presents a literature review and proposes a model of the contextual and individual factors…

78 FR 13141 - 30-Day Notice of Proposed Information Collection: Exchange Visitor Program Participant Survey...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-26

...: Exchange Visitor Program Participant Survey--Summer Work Travel ACTION: Notice of request for public... of Information Collection: Exchange Visitor Program Participant Survey--Summer Work Travel Program... participants in the Summer Work Travel category. Estimated Number of Respondents: 109,000. Estimated Number of...

Corona from Ice, Thunderstorm Electrification and Lightning Suppression.

DTIC Science & Technology

1980-11-01

rates of droplets highly charged by interaction with corona streamers. Laboratory and theoretical studies have been performed in an effort to explore in...CORONA FROM ICE, THUNDERSTORM ELECTRIFICATION Final AND LIGHTNING SUPPRESSION 1 Sep 77 to 31 Aug 80 6. Performing Org. Report Number 7. Author(s) 8...Contract or Grant Number J. Latham AFOSR-77-3429 O"o 9. Performing Organization Name and Address 10. Program Element, Project, Task Physics Department

Life sciences and space research 25 (1). Gravitational biology; Interdisciplinary Scientific Commission F of the COSPAR Plenary Meeting, 29th, Washington, DC, Aug. 28-Sep. 5, 1992

NASA Technical Reports Server (NTRS)

Cogoli, A. (Editor); Cogoli-Greuter, M. (Editor); Gruener, R. (Editor); Sievers, A. (Editor); Ubbels, G. A. (Editor); Halstead, T. W. (Editor); Ross, M. D. (Editor); Roux, S. J. (Editor); Oser, H. (Editor); Lujan, B. F. (Editor)

1994-01-01

The conference includes papers describing theories and models of cell biology in microgravity and weightlessness; experimental research on cellular responses to altered gravity in plants and animals, natural and simulated; graviresponses in plants; gravitational effects in developmental biology; mechanisms of gravisensing; effects on animals and humans; and educational programs in Space Life Sciences.

Patent Abstract Digest. Volume I.

DTIC Science & Technology

1979-04-30

compact. self -contained transducer unit for 151) Field of Stucek............... 73/71 5 US, 67.5 R. electromagnetic generation and detection of...BSTRACT SPONSORED PROGRAMS FROM THE AIR FORCE SYSTEMS COMMAND United States Patent 1191 (111 4,115,616 Heitz et &1. (45 Sep. 19, 1978 154) SELF -SEALING...ioseph E. Rutz; Wiliam J.O’Brien (221 Filed: F . (57 ABSTRACT A self -sealing multi-laminated fuel line composite mate. rial composed of (a) a plastic

Translations on Telecommunications Policy, Research and Development No. 26

DTIC Science & Technology

1978-01-06

Revolution, residents of Yerevan and the Ararat Valley received the oppor- tunity to watch Central Television’s fourth program being retransmitted on...PROTEO SYSTEM Milan TELECOMUNICAZIONI in Italian Nos 60-61 Sep-Dec 76 PP 21-34 [Article by Guido Arrigoni, Sergio Dal Monte and Giorgio Magnolfi, of SIT...Boston, June 1975. 8. Arrigoni, G., Di Stefano, G.B., Dal Monte , S., Magnolfi, G. "PROTEO Sys- tem: Field Experience of PROTEO Peripheral

Physics of Coupled CME and Flare Systems

DTIC Science & Technology

2016-12-21

AFRL-RV-PS- AFRL-RV-PS- TR-2016-0162 TR-2016-0162 PHYSICS OF COUPLED CME AND FLARE SYSTEMS K. S. Balasubramaniam, et al. 21 December 2016 Final...30 Sep 2016 4. TITLE AND SUBTITLE Physics of Coupled CME and Flare Systems 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 61102F...objectives for this task were: (i) derive measureable physical properties and discernible structural circumstances in solar active regions that

Lightweight Zerodur Mirror Technology

DTIC Science & Technology

1982-10-01

17 September 1981 Contract Expiration Date: 15 May 1982 Short Title of Work: Lightweight Zerodur Mirror Technology Program Code Number: 1LIO Period of...iepRA LIGHTWEIGHT ZERODUR MIRROR TECHNOLOGY 21 Sep 81 - 21 May 82 1. PERFORMING 0,10. REPORT NUMWERn 15512 7: AUTHOR(*J S. CONTRACT OR GRANT NUMSER[JlII...1S. KIEV WORDS (Continue on reverse aide If necesery 1nd Identify b? block nwi nhm ) Zerodur Lightweight Mirrors Mirror Blank Fabrication Frit

Laser Assisted Microsurgical Anastomosis.

DTIC Science & Technology

1983-09-22

motion exercises of the patient post surgery and for the development of appropriate regimes for nursing and general rehabilitation of the patient...8217AD-Ai4S 48? LASER ASSISTED MICROSUROICAL ANASTOMOSIS(U) MIAMI UNIV i/i FL DEPT OF ORTHOPAEDICS AND REHABILITATION N E BURKHALTER 22 SEP 83 NBBI4-i-K...William E. Burkhalter, M.D. NOO014-81-K-0446 Professor of Orthopaedics and Rehabilitation 0. PERFORMING ORGANIZATION NAME AND ADDRESS 10. PROGRAM

Translations on Telecommunications Policy, Research and Development No. 57.

DTIC Science & Technology

1978-10-27

satellite communications station may be dedicated in December this year. [La Paz PRESENCIA in Spanish 17 Sep 78 p 12 PY] CSO: 5500 40 BRAZIL INPI...outside world has hamper- ed Zambia’s efforts in the promotion of cooperation for political, economic, social and cultural security and defence and...the thought that Finns would have ^ opportunity to follow "television programs produced in a different political and social environment". 75

C-130 Corrosion Prevention and Control Program

DTIC Science & Technology

2011-08-01

hexavalent chrome … Warner Robins Air Logistics Center People First…Mission Always SIBR Projects  Back Scatter X-Ray NDI  Detect concealed...Projects Listing Future Projects  Chrome -Free Coating Systems Flight Tests • AkzoNobel (Sep-Oct 2011) – PreKote – Aerodur 2100 magnesium rich...primer (MgRP) – Aerodur 5000 topcoat color #36173 • Deft (June 2012) – Rare earth conversion coating (RECC) 1015/3021 – 02-GN-093 chrome -free

JPRS Report China.

DTIC Science & Technology

1988-11-30

jang’s Political Performance, Prospects Evaluated [TZULI WANPAO 11 Sep] 54 Lifelong Maverick Role of Hu Ch’iu-yuan Portrayed [TZULI WANPAO 25 Sep...42050005a Selangor SIN CHEW JIT POH in Chinese 24 Sep 88 p 1 [Text] The visiting Tianjin trade delegation plans to buy Malaysian rubber, palm oil...Datuk Kok Wee Kiat. Mr Hu added that Tianjin has always bought Malaysian rubber and palm oil directly but imported timber from other countries

Low cost computer subsystem for the Solar Electric Propulsion Stage (SEPS)

NASA Technical Reports Server (NTRS)

1975-01-01

The Solar Electric Propulsion Stage (SEPS) subsystem which consists of the computer, custom input/output (I/O) unit, and tape recorder for mass storage of telemetry data was studied. Computer software and interface requirements were developed along with computer and I/O unit design parameters. Redundancy implementation was emphasized. Reliability analysis was performed for the complete command computer sybsystem. A SEPS fault tolerant memory breadboard was constructed and its operation demonstrated.

Neurophysiological Changes Measured Using Somatosensory Evoked Potentials.

PubMed

Macerollo, Antonella; Brown, Matt J N; Kilner, James M; Chen, Robert

2018-05-01

Measurements of somatosensory evoked potentials (SEPs), recorded using electroencephalography during different phases of movement, have been fundamental in understanding the neurophysiological changes related to motor control. SEP recordings have also been used to investigate adaptive plasticity changes in somatosensory processing related to active and observational motor learning tasks. Combining noninvasive brain stimulation with SEP recordings and intracranial SEP depth recordings, including recordings from deep brain stimulation electrodes, has been critical in identifying neural areas involved in specific temporal stages of somatosensory processing. Consequently, this fundamental information has furthered our understanding of the maladaptive plasticity changes related to pathophysiology of diseases characterized by abnormal movements, such as Parkinson's disease, dystonia, and functional movement disorders. Crown Copyright © 2018. Published by Elsevier Ltd. All rights reserved.

The Scenario-Based Engineering Process (SEP): a user-centered approach for the development of health care systems.

PubMed

Harbison, K; Kelly, J; Burnell, L; Silva, J

1995-01-01

The Scenario-based Engineering Process (SEP) is a user-focused methodology for large and complex system design. This process supports new application development from requirements analysis with domain models to component selection, design and modification, implementation, integration, and archival placement. It is built upon object-oriented methodologies, domain modeling strategies, and scenario-based techniques to provide an analysis process for mapping application requirements to available components. We are using SEP in the health care applications that we are developing. The process has already achieved success in the manufacturing and military domains and is being adopted by many organizations. SEP should prove viable in any domain containing scenarios that can be decomposed into tasks.

Correlating Type II and III Radio Bursts with Solar Energetic Particle Events

NASA Astrophysics Data System (ADS)

Ledbetter, K.; Winter, L. M.; Quinn, R. A.

2013-12-01

Solar energetic particles (SEPs) are high-energy particles, such as protons, which are accelerated at the Sun and speed outward into the solar system. If they reach Earth, they can be harmful to satellites, ionospheric communications, and humans in space or on polar airline routes. NOAA defines an SEP event as an occasion when the flux of protons with energies higher than 10 MeV exceeds 10 pfu (particle flux units) as measured by the GOES satellites in geosynchronous orbit. The most intense SEP events are associated with shocks, driven by coronal mass ejections (CMEs), which accelerate particles as they move through the corona. However, very few CMEs result in SEP events. To determine what factors are most important in distinguishing the shock waves that will result in SEP acceleration toward Earth, we take into account several variables and perform a principal component analysis (PCA) to examine their correlations. First, we examine Type II radio bursts, which are caused by electrons accelerating in the same CME-driven shocks that can accelerate SEPs. Using data from the WAVES instrument on the WIND satellite, these Type II radio bursts, as well as the Type III bursts that often accompany them, can be characterized by slope in 1/f space and by intensity. In addition, local Langmuir waves detected by WIND, which are caused by electrons speeding through the plasma surrounding the satellite, can be an indicator of the magnetic connectivity between the active region and Earth. Finally, X-ray flares directly preceding the Type II burst are also taken into consideration in the PCA analysis. The accompanying figure illustrates an example of the WAVES solar radio bursts along with the GOES solar proton flux >= 10 MeV during the SEP event on April 11, 2013. Using PCA to determine which of these factors are most relevant to the onset, intensity, and duration of SEP events will be valuable in future work to predict such events. In total, we present the analysis of all type II radio bursts observed by WIND between January 2010 and May 2013. Future work will include the STEREO/SWAVES data with a focus on creating an operating real-time SEP forecaster relying on radio, X-ray, and proton flux observations.

Dynamics of Solar Energetic Particles in the Presence of a Shock Wave

NASA Astrophysics Data System (ADS)

Timofeev, V. E.; Petukhov, Ivan; Petukhov, Stanislav; Starodubtsev, Sergei

2003-07-01

From the analysis of problem solutions on the solar energetic particle propagation in the presence of a plane shock wave described by the diffusion convective transport equation, the condition and manifestations for the influence of a shock wave on the SEP propagation in the solar wind have been determined. Solar energetic particles (SEP) in gradual events are generated by shock waves (see, for example, [1] and references there). The SEP generation region is limited, on the whole, by the solar corona. Proton fluxes of 470 MeV to 21 GeV energies, a maximum of which occur at a time when the shock in the atmosphere of the Sun reaches heights equal to 5 10 solar radii [2] indicate to it. It is also confirmed by the significant advancing of the occurrence time of maximum in the SEP intensity with kinetic energies more than 10 MeV relative to the shock front arrival moment to Earth's orbit. model calculations for the particles acceleration by the diffusive mechanism in conditions, typical for the solar corona, show that the time taken to pass the solar atmosphere by the shock is quite sufficient to form the particle spectrum corresponding to the SEP characteristics observed [3,4]. Lee and Ryan [5] investigated the problem of SEP gradual event generation, propagation and confirmed the close association between the diffusive acceleration mechanism and SEP events. The absence of depending of particle diffusion coefficients on the energy is a lack of this model. As an extension of preceding investigations, in this work the temporal dynamics of the particle spectrum in the presence of a plane shock for diffusion coefficients depending on the particle energy and also their change in time is studied. The SEP event from a moment of arising of a shock to a moment of it's arrival on the Earth's orbit can be divided on two stages: the first stage (duration is ˜ 1 hour) is a generation of SEP in the solar corona, the second stage (duration is ˜ 1 day) is a propagation in interplanetary space in the presence of a shock. Here we consider the second stage only which as believed to be began with the injection of the particle spectrum formed during the first stage.

The Abundance of Helium in the Source Plasma of Solar Energetic Particles

NASA Astrophysics Data System (ADS)

Reames, Donald V.

2017-11-01

Studies of patterns of abundance enhancements of elements, relative to solar coronal abundances, in large solar energetic-particle (SEP) events, and of their power-law dependence on the mass-to-charge ratio, A/Q, of the ions, have been used to determine the effective source-plasma temperature, T, that defines the Q-values of the ions. We find that a single assumed value for the coronal reference He/O ratio in all SEP events is often inconsistent with the transport-induced power-law trend of the other elements. In fact, the coronal He/O varies rather widely from one SEP event to another. In the large Fe-rich SEP events with T ≈ 3 MK, where shock waves, driven out by coronal mass ejections (CMEs), have reaccelerated residual ions from impulsive suprathermal events that occur earlier in solar active regions, He/O ≈ 90, a ratio similar to that in the slow solar wind, which may also originate from active regions. Ions in the large SEP events with T < 2 MK may be accelerated outside active regions, and have values of 40 ≤ He/O ≤ 60. Mechanisms that determine coronal abundances, including variations of He/O, are likely to occur near the base of the corona (at ≈ 1.1 RS) and thus to affect both SEPs (at 2 - 3 RS) and the solar wind. Other than He, reference coronal abundances for heavier elements show little temperature dependence or systematic difference between SEP events; He, the element with the highest first-ionization potential, is unique. The CME-driven shock waves probe the same regions of space, at ≈ 2 RS near active regions, which are also likely sources of the slow solar wind, providing complementary information on conditions in those regions.