Complex Dynamics of Wetland Ecosystem with Nonlinear Harvesting: Application to Chilika Lake in Odisha, India

NASA Astrophysics Data System (ADS)

Upadhyay, Ranjit Kumar; Tiwari, S. K.; Roy, Parimita

2015-06-01

In this paper, an attempt has been made to study the spatial and temporal dynamical interactions among the species of wetland ecosystem through a mathematical model. The model represents the population dynamics of phytoplankton, zooplankton and fish species found in Chilika lake, Odisha, India. Nonlinear stability analysis of both the temporal and spatial models has been carried out. Maximum sustainable yield and optimal harvesting policy have been studied for a nonspatial model system. Numerical simulation has been performed to figure out the parameters responsible for the complex dynamics of the wetland system. Significant outcomes of our numerical findings and their interpretations from an ecological point of view are provided in this paper. Numerical simulation of spatial model exhibits some interesting and beautiful patterns. We have also pointed out the parameters that are responsible for the good health of wetland ecosystem.

Spatial and temporal variability of microgeographic genetic structure in white-tailed deer

USGS Publications Warehouse

Scribner, Kim T.; Smith, Michael H.; Chesser, Ronald K.

1997-01-01

Techniques are described that define contiguous genetic subpopulations of white-tailed deer (Odocoileus virginianus) based on the spatial dispersion of 4,749 individuals that possessed discrete character values (alleles or genotypes) during each of 6 years (1974-1979). White-tailed deer were not uniformly distributed in space, but exhibited considerable spatial genetic structuring. Significant non-random clusters of individuals were documented during each year based on specific alleles and genotypes at the Sdh locus. Considerable temporal variation was observed in the position and genetic composition of specific clusters, which reflected changes in allele frequency in small geographic areas. The position of clusters did not consistently correspond with traditional management boundaries based on major discontinuities in habitat (swamp versus upland) and hunt compartments that were defined by roads and streams. Spatio-temporal stability of observed genetic contiguous clusters was interpreted relative to method and intensity of harvest, movements, and breeding ecology.

Linking the soil moisture distribution pattern to dynamic processes along slope transects in the Loess Plateau, China.

PubMed

Wang, Shuai; Fu, Bojie; Gao, Guangyao; Zhou, Ji; Jiao, Lei; Liu, Jianbo

2015-12-01

Soil moisture pulses are a prerequisite for other land surface pulses at various spatiotemporal scales in arid and semi-arid areas. The temporal dynamics and profile variability of soil moisture in relation to land cover combinations were studied along five slopes transect on the Loess Plateau during the rainy season of 2011. Within the 3 months of the growing season coupled with the rainy season, all of the soil moisture was replenished in the area, proving that a type stability exists between different land cover soil moisture levels. Land cover combinations disturbed the trend determined by topography and increased soil moisture variability in space and time. The stability of soil moisture resulting from the dynamic processes could produce stable patterns on the slopes. The relationships between the mean soil moisture and vertical standard deviation (SD) and coefficient of variation (CV) were more complex, largely due to the fact that different land cover types had distinctive vertical patterns of soil moisture. The spatial SD of each layer had a positive correlation and the spatial CV exhibited a negative correlation with the increase in mean soil moisture. The soil moisture stability implies that sampling comparisons in this area can be conducted at different times to accurately compare different land use types.

Modified symplectic schemes with nearly-analytic discrete operators for acoustic wave simulations

NASA Astrophysics Data System (ADS)

Liu, Shaolin; Yang, Dinghui; Lang, Chao; Wang, Wenshuai; Pan, Zhide

2017-04-01

Using a structure-preserving algorithm significantly increases the computational efficiency of solving wave equations. However, only a few explicit symplectic schemes are available in the literature, and the capabilities of these symplectic schemes have not been sufficiently exploited. Here, we propose a modified strategy to construct explicit symplectic schemes for time advance. The acoustic wave equation is transformed into a Hamiltonian system. The classical symplectic partitioned Runge-Kutta (PRK) method is used for the temporal discretization. Additional spatial differential terms are added to the PRK schemes to form the modified symplectic methods and then two modified time-advancing symplectic methods with all of positive symplectic coefficients are then constructed. The spatial differential operators are approximated by nearly-analytic discrete (NAD) operators, and we call the fully discretized scheme modified symplectic nearly analytic discrete (MSNAD) method. Theoretical analyses show that the MSNAD methods exhibit less numerical dispersion and higher stability limits than conventional methods. Three numerical experiments are conducted to verify the advantages of the MSNAD methods, such as their numerical accuracy, computational cost, stability, and long-term calculation capability.

Combi-metal organic framework (Combi-MOF) of α-amylase and glucoamylase for one pot starch hydrolysis.

PubMed

Salgaonkar, Manish; Nadar, Shamraja S; Rathod, Virendra K

2018-07-01

The multi-enzyme biocatalyst allows to run in vitro multi-step cascade reactions in single pot. An efficient combi-metal organic frameworks (combi-MOF) of α-amylase and glucoamylase for one pot starch hydrolysis was constructed by mixing zinc acetate and 2‑methylimmidazole with enzyme mixture in one pot under biocompatible conditions. The prepared combi-MOF was characterized and analyzed by powder X-ray diffraction (PXRD), Fourier transform infrared (FT-IR), thermogravimetric analysis (TGA) and scanning electron microscopy (SEM). Thermo-stability was evaluated for combi-MOF in the range of 55 to 75°C which showed three folds improved stability in terms of half-life. In kinetic parameter studies, rate of starch hydrolysis (V max ) of combi-MOF was found to be enhanced after co-immobilization. Further, combi-MOF was recycled in batch mode which retained up to 52% residual activity after five successive cycles of reuse. In addition to that, combi-MOF exhibited extraordinary storage stability till 24days. At the end, starch hydrolytic activity of combi-MOF was tested for different sources of starch (corn, rice, wheat and potato) which exhibited higher rate of hydrolysis than mixture of free enzymes due to spatially co-localized multi-enzymatic systems. Copyright © 2018 Elsevier B.V. All rights reserved.

Localized states in an unbounded neural field equation with smooth firing rate function: a multi-parameter analysis.

PubMed

Faye, Grégory; Rankin, James; Chossat, Pascal

2013-05-01

The existence of spatially localized solutions in neural networks is an important topic in neuroscience as these solutions are considered to characterize working (short-term) memory. We work with an unbounded neural network represented by the neural field equation with smooth firing rate function and a wizard hat spatial connectivity. Noting that stationary solutions of our neural field equation are equivalent to homoclinic orbits in a related fourth order ordinary differential equation, we apply normal form theory for a reversible Hopf bifurcation to prove the existence of localized solutions; further, we present results concerning their stability. Numerical continuation is used to compute branches of localized solution that exhibit snaking-type behaviour. We describe in terms of three parameters the exact regions for which localized solutions persist.

The relationship between the spatial scaling of biodiversity and ecosystem stability

PubMed Central

Delsol, Robin; Loreau, Michel; Haegeman, Bart

2018-01-01

Aim Ecosystem stability and its link with biodiversity have mainly been studied at the local scale. Here we present a simple theoretical model to address the joint dependence of diversity and stability on spatial scale, from local to continental. Methods The notion of stability we use is based on the temporal variability of an ecosystem-level property, such as primary productivity. In this way, our model integrates the well-known species–area relationship (SAR) with a recent proposal to quantify the spatial scaling of stability, called the invariability–area relationship (IAR). Results We show that the link between the two relationships strongly depends on whether the temporal fluctuations of the ecosystem property of interest are more correlated within than between species. If fluctuations are correlated within species but not between them, then the IAR is strongly constrained by the SAR. If instead individual fluctuations are only correlated by spatial proximity, then the IAR is unrelated to the SAR. We apply these two correlation assumptions to explore the effects of species loss and habitat destruction on stability, and find a rich variety of multi-scale spatial dependencies, with marked differences between the two assumptions. Main conclusions The dependence of ecosystem stability on biodiversity across spatial scales is governed by the spatial decay of correlations within and between species. Our work provides a point of reference for mechanistic models and data analyses. More generally, it illustrates the relevance of macroecology for ecosystem functioning and stability. PMID:29651225

Stability Enhancement of Silver Nanowire Networks with Conformal ZnO Coatings Deposited by Atmospheric Pressure Spatial Atomic Layer Deposition.

PubMed

Khan, Afzal; Nguyen, Viet Huong; Muñoz-Rojas, David; Aghazadehchors, Sara; Jiménez, Carmen; Nguyen, Ngoc Duy; Bellet, Daniel

2018-06-06

Silver nanowire (AgNW) networks offer excellent electrical and optical properties and have emerged as one of the most attractive alternatives to transparent conductive oxides to be used in flexible optoelectronic applications. However, AgNW networks still suffer from chemical, thermal, and electrical instabilities, which in some cases can hinder their efficient integration as transparent electrodes in devices such as solar cells, transparent heaters, touch screens, and organic light emitting diodes. We have used atmospheric pressure spatial atomic layer deposition (AP-SALD) to fabricate hybrid transparent electrode materials in which the AgNW network is protected by a conformal thin layer of zinc oxide. The choice of AP-SALD allows us to maintain the low-cost and scalable processing of AgNW-based transparent electrodes. The effects of the ZnO coating thickness on the physical properties of AgNW networks are presented. The composite electrodes show a drastic enhancement of both thermal and electrical stabilities. We found that bare AgNWs were stable only up to 300 °C when subjected to thermal ramps, whereas the ZnO coating improved the stability up to 500 °C. Similarly, ZnO-coated AgNWs exhibited an increase of 100% in electrical stability with respect to bare networks, withstanding up to 18 V. A simple physical model shows that the origin of the stability improvement is the result of hindered silver atomic diffusion thanks to the presence of the thin oxide layer and the quality of the interfaces of hybrid electrodes. The effects of ZnO coating on both the network adhesion and optical transparency are also discussed. Finally, we show that the AP-SALD ZnO-coated AgNW networks can be effectively used as very stable transparent heaters.

Discriminating the effects of spatial extent and population size in cyclic competition among species

NASA Astrophysics Data System (ADS)

Lamouroux, David; Eule, Stephan; Geisel, Theo; Nagler, Jan

2012-02-01

Quantifying and understanding the stability and biodiversity of ecosystems is a major task in biological physics as well as in theoretical ecology. From the perspective of game theory, this is highly relevant for questions pertaining to the emergence of cooperation or the coexistence of cyclically competing species. The latter has been recently proposed as a paradigm for biodiversity and it has been shown that the mobility of individuals can support the stability of biodiversity by the formation of spirals. In this contribution, we present a population model for species under cyclic competition that extends earlier lattice models to allow the single cells to accommodate more than one individual by introducing a per cell carrying capacity. We confirm that the emergence of spirals induce a transition from an unstable to a stable regime. This transition however does not appear to be sharp and we find a broad intermediate regime that exhibits an ambiguous behavior. The separation of the two regimes by the usual scaling analysis is thus hampered. The newly introduced carrying capacity offers an alternative way of characterizing the transition. We thus overcome the original limitations by separately analyzing the effect of spatial extent and population size.

Fundamental properties of cooperative contagion processes

NASA Astrophysics Data System (ADS)

Chen, Li; Ghanbarnejad, Fakhteh; Brockmann, Dirk

2017-10-01

We investigate the effects of cooperativity between contagion processes that spread and persist in a host population. We propose and analyze a dynamical model in which individuals that are affected by one transmissible agent A exhibit a higher than baseline propensity of being affected by a second agent B and vice versa. The model is a natural extension of the traditional susceptible-infected-susceptible model used for modeling single contagion processes. We show that cooperativity changes the dynamics of the system considerably when cooperativity is strong. The system exhibits discontinuous phase transitions not observed in single agent contagion, multi-stability, a separation of the traditional epidemic threshold into different thresholds for inception and extinction as well as hysteresis. These properties are robust and are corroborated by stochastic simulations on lattices and generic network topologies. Finally, we investigate wave propagation and transients in a spatially extended version of the model and show that especially for intermediate values of baseline reproduction ratios the system is characterized by various types of wave-front speeds. The system can exhibit spatially heterogeneous stationary states for some parameters and negative front speeds (receding wave fronts). The two agent model can be employed as a starting point for more complex contagion processes, involving several interacting agents, a model framework particularly suitable for modeling the spread and dynamics of microbiological ecosystems in host populations.

Synthesis of Multifunctional Nanoparticles for Cancer Diagnostics and Therapeutics

NASA Astrophysics Data System (ADS)

Fang, Chen

2011-12-01

Magnetic nanoparticles (MNPs) have attracted enormous research attention due to their unique magnetic properties that enable the detection by the non-invasive medical imaging modality---magnetic resonance imaging (MRI). By incorporating advanced features, such as specific targeting, multimodality, therapeutic delivery, the detectability and applicability of MNPs have been dramatically expanded. Smart and rational design on structure, composition and surface chemistry is essential to achieving desired properties in MNP systems, such as high sensitivity and colloidal stability, target specificity and/or multimodality. The goal of this research is to develop MNP-based platforms for the detection, diagnosis and treatment of cancer. MNPs with high contrast enhancement were coated with poly(ethylene glycol) (PEG)-based polymers to render aqueous stability and confer therapeutic-loading capability. Tumor-specific MNPs were developed by functionalization of nanoparticles with chlorotoxin (CTX) or arginine-glycine-aspartic acid (RGD) that targets, respectively, MMP-2 receptor or alphavbeta3 integrin overexpressed on a variety of cancer cells. The effects of ligands' molecular targets on the temporal and spatial distribution of MNPs within tumors were also investigated both in vitro and in vivo. All MNPs exhibited excellent long-term stability in cell culture media. CTX-labeled MNP exhibited sustained accumulation, penetration and distribution in the tumor mass. These findings revealed the influence of the targeting ligands on the intratumoral distribution of the ligand-enabled nanoprobes. To demonstrate the ability of nanoparticles as drug carrier, anthracyline chemotherapeutic drugs doxorubicin and mitoxantrone were attached to iron oxide nanoparticles. The theragnostic nanoparticles showed sufficient contrast enhancement and comparable anti-neoplastic efficacy in vitro. With flexible surface chemistry, our nanoparticle platform can be used in a modular fashion to conjugate biomolecules for intended applications, and the functionalized nanoparticle systems retain a prolonged stability and exhibit high tumor specificity. The study would establish the foundation for future development of integrated theragnostic systems for the treatment of cancer and other complex diseases.

Cortical activity is more stable when sensory stimuli are consciously perceived

PubMed Central

Schurger, Aaron; Sarigiannidis, Ioannis; Naccache, Lionel; Sitt, Jacobo D.; Dehaene, Stanislas

2015-01-01

According to recent evidence, stimulus-tuned neurons in the cerebral cortex exhibit reduced variability in firing rate across trials, after the onset of a stimulus. However, in order for a reduction in variability to be directly relevant to perception and behavior, it must be realized within trial—the pattern of activity must be relatively stable. Stability is characteristic of decision states in recurrent attractor networks, and its possible relevance to conscious perception has been suggested by theorists. However, it is difficult to measure on the within-trial time scales and broadly distributed spatial scales relevant to perception. We recorded simultaneous magneto- and electroencephalography (MEG and EEG) data while subjects observed threshold-level visual stimuli. Pattern-similarity analyses applied to the data from MEG gradiometers uncovered a pronounced decrease in variability across trials after stimulus onset, consistent with previous single-unit data. This was followed by a significant divergence in variability depending upon subjective report (seen/unseen), with seen trials exhibiting less variability. Applying the same analysis across time, within trial, we found that the latter effect coincided in time with a difference in the stability of the pattern of activity. Stability alone could be used to classify data from individual trials as “seen” or “unseen.” The same metric applied to EEG data from patients with disorders of consciousness exposed to auditory stimuli diverged parametrically according to clinically diagnosed level of consciousness. Differences in signal strength could not account for these results. Conscious perception may involve the transient stabilization of distributed cortical networks, corresponding to a global brain-scale decision. PMID:25847997

Spatially dependent responses of a large-river fish assemblage to bank stabilization and side channels

USGS Publications Warehouse

Reinhold, Ann Marie; Bramblett, Robert G.; Zale, Alexander V.; Poole, Geoffrey C.; Roberts, David W.

2017-01-01

The alteration of rivers by anthropogenic bank stabilization to prevent the erosion of economically valuable lands and structures has become commonplace. However, such alteration has ambiguous consequences for fish assemblages, especially in large rivers. Because most large, temperate rivers have impoundments, it can be difficult to separate the influences of bank stabilization structures from those of main-stem impoundments, especially because both stabilization structures and impoundments can cause side-channel loss. Few large rivers are free flowing and retain extensive side channels, but the Yellowstone River (our study area) is one such river. We hypothesized that in this river (1) bank stabilization has changed fish assemblage structure by altering habitats, (2) side-channel availability has influenced fish assemblage structure by providing habitat heterogeneity, and (3) the influences of bank stabilization and side channels on fish assemblages were spatially scale dependent. We developed a spatially explicit framework to test these hypotheses. Fish assemblage structure varied with the extent of bank stabilization and the availability of side channels; however, not all assemblage subsets were influenced. Nevertheless, bank stabilization and side channels had different and sometimes opposite influences on the fish assemblage. The effects of side channels on fish were more consistent and widespread than those of bank stabilization; the catches of more fishes were positively correlated with side-channel availability than with the extent of bank stabilization. The influences of bank stabilization and side channels on the relative abundances of fish also varied, depending on species and river bend geomorphology. The variation in river morphology probably contributed to the assemblage differences between stabilized and reference river bends; stabilized alluvial pools were deeper than reference alluvial pools, but the depths of stabilized and reference bluff pools did not differ. The strengths of the relationships among fish assemblages, bank stabilization, and side channels were spatially scale dependent; optimum spatial scales ranged from less than 200 m to 3,200 m up- and downstream, suggesting that bank stabilization and side channels influenced fish assemblages across multiple spatial scales.

Bubble and skyrmion crystals in frustrated magnets with easy-axis anisotropy

DOE PAGES

Hayami, Satoru; Lin, Shi-Zeng; Batista, Cristian D.

2016-05-12

We clarify the conditions for the emergence of multiple-Q structures out of lattice and easy-axis spin anisotropy in frustrated magnets. By considering magnets whose exchange interaction has multiple global minima in momentum space, we find that both types of anisotropy stabilize triple-Q orderings. Moderate anisotropy leads to a magnetic field-induced skyrmion crystal, which evolves into a bubble crystal for increasing spatial and spin anisotropy. Finally, the bubble crystal exhibits a quasi-continuous (devil’s staircase) temperature dependent ordering wave-vector, characteristic of the competition between frustrated exchange and strong easy-axis anisotropy.

Spatial-temporal variability of soil water content in a cropland-shelterbelt-desert site in an arid inland river basin of Northwest China

NASA Astrophysics Data System (ADS)

Shen, Qin; Gao, Guangyao; Hu, Wei; Fu, Bojie

2016-09-01

Knowledge of the spatial-temporal variability of soil water content (SWC) is critical for understanding a range of hydrological processes. In this study, the spatial variance and temporal stability of SWC were investigated in a cropland-shelterbelt-desert site at the oasis-desert ecotone in the middle of the Heihe River Basin, China. The SWC was measured on 65 occasions to a depth of 2.8 m at 45 locations during two growing seasons from 2012 to 2013. The standard deviation of the SWC versus the mean SWC exhibited a convex upward relationship in the shelterbelt with the greatest spatial variation at the SWC of around 22.0%, whereas a linearly increasing relationship was observed for the cropland, desert, and land use pattern. The standard deviation of the relative difference was positively linearly correlated with the SWC (p < 0.05) for the land use pattern, whereas such a relationship was not found in the three land use types. The spatial pattern of the SWC was more time stable for the land use pattern, followed by desert, shelterbelt, and cropland. The spatial pattern of SWC changed dramatically among different soil layers. The locations representing the mean SWC varied with the depth, and no location could represent the whole soil profile due to different soil texture, root distribution and irrigation management. The representative locations of each soil layer could be used to estimate the mean SWC well. The statistics of temporal stability of the SWC could be presented equally well with a low frequency of observation (30-day interval) as with a high frequency (5-day interval). Sampling frequency had little effect on the selection of the representative locations of the field mean SWC. This study provides useful information for designing the optimal strategy for sampling SWC at the oasis-desert ecotone in the arid inland river basin.

Scale dependence of the diversity-stability relationship in a temperate grassland.

PubMed

Zhang, Yunhai; He, Nianpeng; Loreau, Michel; Pan, Qingmin; Han, Xingguo

2018-05-01

A positive relationship between biodiversity and ecosystem stability has been reported in many ecosystems; however, it has yet to be determined whether and how spatial scale affects this relationship. Here, for the first time, we assessed the effects of alpha, beta and gamma diversity on ecosystem stability and the scale dependence of the slope of the diversity-stability relationship.By employing a long-term (33 years) dataset from a temperate grassland, northern China, we calculated the all possible spatial scales with the complete combination from the basic 1-m 2 plots.Species richness was positively associated with ecosystem stability through species asynchrony and overyielding at all spatial scales (1, 2, 3, 4 and 5 m 2 ). Both alpha and beta diversity were positively associated with gamma stability.Moreover, the slope of the diversity-area relationship was significantly higher than that of the stability-area relationship, resulting in a decline of the slope of the diversity-stability relationship with increasing area. Synthesis. With the positive species diversity effect on ecosystem stability from small to large spatial scales, our findings demonstrate the need to maintain a high biodiversity and biotic heterogeneity as insurance against the risks incurred by ecosystems in the face of global environmental changes.

Spatial stabilization and intensification of moistening and drying rate patterns under future climate change

NASA Astrophysics Data System (ADS)

Chavaillaz, Y.; Joussaume, S.; Bony, S.; Braconnot, P.

2015-12-01

Most climate studies characterize the future climate change by considering the evolution between a fixed current baseline and the future. It emphasizes an increase of future precipitation changes with global warming. Here we use an alternative approach that considers rate of change indicators related to precipitation using projections of an ensemble of General Circulation Models. The rate is defined by the difference between two subsequent 20-year periods. This approach can be relevant to impacts affecting upcoming generations, and to their continuous adaptation towards a changing target. Under the strongest emission pathway (RCP8.5), moistening and drying rates strongly increase at the global scale. As we move further over the twenty-first century, more and more regions exhibit substantial rates. These regions are modified over time due to spatial variability of precipitation. However, we show that they tend to become more geographically stationary through the century, leading to persisting trends at several places over the globe. Whilst global warming is accelerating, this spatial stabilization is due to the decreasing relative influence of global circulation in precipitation changes compared to thermodynamic processes. In specific regions, the combination of intensification and persistence of such substantial rates should be considered in the framework of future impact studies (i.e. the Mediterranean Sea, Central America, South Asia and the Arctic). These trends are already visible in the current period, but could almost disappear if strong mitigation policies (RCP2.6) were quickly implemented.

Asynchrony among local communities stabilises ecosystem function of metacommunities.

PubMed

Wilcox, Kevin R; Tredennick, Andrew T; Koerner, Sally E; Grman, Emily; Hallett, Lauren M; Avolio, Meghan L; La Pierre, Kimberly J; Houseman, Gregory R; Isbell, Forest; Johnson, David Samuel; Alatalo, Juha M; Baldwin, Andrew H; Bork, Edward W; Boughton, Elizabeth H; Bowman, William D; Britton, Andrea J; Cahill, James F; Collins, Scott L; Du, Guozhen; Eskelinen, Anu; Gough, Laura; Jentsch, Anke; Kern, Christel; Klanderud, Kari; Knapp, Alan K; Kreyling, Juergen; Luo, Yiqi; McLaren, Jennie R; Megonigal, Patrick; Onipchenko, Vladimir; Prevéy, Janet; Price, Jodi N; Robinson, Clare H; Sala, Osvaldo E; Smith, Melinda D; Soudzilovskaia, Nadejda A; Souza, Lara; Tilman, David; White, Shannon R; Xu, Zhuwen; Yahdjian, Laura; Yu, Qiang; Zhang, Pengfei; Zhang, Yunhai

2017-12-01

Temporal stability of ecosystem functioning increases the predictability and reliability of ecosystem services, and understanding the drivers of stability across spatial scales is important for land management and policy decisions. We used species-level abundance data from 62 plant communities across five continents to assess mechanisms of temporal stability across spatial scales. We assessed how asynchrony (i.e. different units responding dissimilarly through time) of species and local communities stabilised metacommunity ecosystem function. Asynchrony of species increased stability of local communities, and asynchrony among local communities enhanced metacommunity stability by a wide range of magnitudes (1-315%); this range was positively correlated with the size of the metacommunity. Additionally, asynchronous responses among local communities were linked with species' populations fluctuating asynchronously across space, perhaps stemming from physical and/or competitive differences among local communities. Accordingly, we suggest spatial heterogeneity should be a major focus for maintaining the stability of ecosystem services at larger spatial scales. © 2017 The Authors. Ecology Letters published by CNRS and John Wiley & Sons Ltd.

A Euclidean Perspective on the Unfolding of Azurin: Spatial Correlations

PubMed Central

Warren, Jeffrey J.; Gray, Harry B.; Winkler, Jay R.; Kozak, John J.

2013-01-01

We investigate the stability to structural perturbation of Pseudomonas aeruginosa azurin using a previously developed geometric model. Our analysis considers Ru(2,2′,6′,2″-terpyridine)(1,10-phenanthroline)(His83)-labeled wild-type azurin and five variants with mutations to Cu-ligating residues. We find that in the early stages of unfolding, the β-strands exhibit the most structural stability. The conserved residues comprising the hydrophobic core are dislocated only after nearly complete unfolding of the β-barrel. Attachment of the Ru-complex at His83 does not destabilize the protein fold, despite causing some degree of structural rearrangement. Notably, replacing the Cys112 and/or Met121 Cu ligands does not affect the conformational integrity of the protein. Notably, these results are in accord with experimental evidence, as well as molecular dynamics simulations of the denaturation of azurin. PMID:23853392

Response dynamics of bluff-body stabilized conical premixed turbulent flames with spatial mixture gradients

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chaudhuri, Swetaprovo; Cetegen, Baki M.

2009-03-15

Response of bluff-body stabilized conical turbulent premixed flames was experimentally studied for a range of excitation frequencies (10-400 Hz), mean flow velocities (5, 10 and 15 m/s) and three different spatial mixture distributions (uniform, inner and outer enrichment). Upstream excitation was provided by a loudspeaker producing velocity oscillation amplitudes of about 8% of the mean flow velocity. Flame response was detected by a photomultiplier observing the CH{sup *} emission from the flame. The studied turbulent flames exhibited transfer function characteristics of a low-pass filter with a cutoff Strouhal number between 0.08 and 0.12. The amplification factors at low frequencies rangedmore » from 2 to 20 and generally increased for mean flow velocities from 5 to 15 m/s. The highest levels of amplification were found for the outer mixture enrichment followed in decreasing order by uniform and inner mixture gradient cases. The high levels of flame response for the outer enrichment case were attributed to the enhanced flame-vortex interaction in outer jet shear layer. At high excitation levels (u{sup '}/U{sub m}{approx}0.3) for U{sub m}=5 m/ s where non-linear flame response is expected, the flame exhibited a reduced amplitude response in the frequency range between 40 and 100 Hz for the uniform and outer equivalence ratio gradient cases and no discernible effect for the inner equivalence ratio gradient. In all cases, transfer function phase was found to vary linearly with excitation frequency. Finally, a relationship between the amplitude characteristics of the bluff-body wake transfer function and flame blowoff equivalence ratio was presented. (author)« less

Stability of parallel electroosmotic flow subject to an axial modulated electric field

NASA Astrophysics Data System (ADS)

Suresh, Vinod; Homsy, George

2001-11-01

The stability of parallel electroosmotic flow in a micro-channel subjected to an AC electric field is studied. A spatially uniform time harmonic electric field is applied along the length of a two-dimensional micro-channel containing a dilute electrolytic solution, resulting in a time periodic parallel flow. The top and bottom walls of the channel are maintained at constant potential. The base state ion concentrations and double layer potential are determined using the Poisson-Boltzmann equation in the Debye-Hückel approximation. Experiments by other workers (Santiago et. al., unpublished) have shown that such a system can exhibit instabilities that take the form of mixing motion occurring in the bulk flow outside the double layer. It is shown that such instabilities can potentially result from the coupling of disturbances in the ion concentrations or electric potential to the base state velocity or ion concentrations, respectively. The stability boundary of the system is determined using Floquet theory and its dependence on the modulation frequency and amplitude of the axial electric field is studied.

The Effect of Symmetry on the Hydrodynamic Stability of and Bifurcation from Planar Shear Flows

DTIC Science & Technology

1990-12-01

Effect of Symmetry on the Hydrodynamic Stability of ant Bifurcation from Planar Shear Flows AFOSR-88-0196 6. AUTHOR(S) 61102F 2304/A4 Thomas J. Bridges 7...December 1990 The Effect of Symmetry on the Hydrodynamic Stability of and Bifurcation from Planar Shear Flows TIIhOMAS J. BIUDGES MATl EM ATIc(AL...spatial stabili’.y into the nonlinear regime and a theory for spa- tial Hopf bifurcation , spatial Floquet theory, wavelength doubling and spatially quasi

Perspectives on the geographic stability and mobility of people in cities

PubMed Central

Hanson, Susan

2005-01-01

A class of questions in the human environment sciences focuses on the relationship between individual or household behavior and local geographic context. Central to these questions is the nature of people's geographic mobility as well as the duration of their locational stability at varying spatial and temporal scales. The problem for researchers is that the processes of mobility/stability are temporally and spatially dynamic and therefore difficult to measure. Whereas time and space are continuous, analysts must select levels of aggregation for both length of time in place and spatial scale of place that fit with the problem in question. Previous work has emphasized mobility and suppressed stability as an analytic category. I focus here on stability and show how analyzing individuals' stability requires also analyzing their mobility. Through an empirical example centered on the relationship between entrepreneurship and place, I demonstrate how a spotlight on stability illuminates a resolution to the measurement problem by highlighting the interdependence between the time and space dimensions of stability/mobility. PMID:16230616

Using the Electromagnetic Induction Method to Connect Spatial Vegetation Distributions with Soil Water and Salinity Dynamics on Steppe Grassland

NASA Astrophysics Data System (ADS)

Jiang, Z.; Li, X.; Wu, H.

2014-12-01

In arid and semi-arid areas, plant growth and productivity are obviously affected by soil water and salinity. But it is not easy to acquire the spatial and temporal dynamics of soil water and salinity by traditional field methods because of the heterogeneity in their patterns. Electromagnetic induction (EMI), for its rapid character, can provide a useful way to solve this problem. Grassland dominated by Achnatherum splendens is an important ecosystem near the Qinghai-Lake watershed on the Qinghai-Tibet Plateau in northwestern China. EMI surveys were conducted for electrical conductivity (ECa) at an intermediate habitat scale (a 60×60 m experimental area) of A. splendens steppe for 18 times (one day only for one time) during the 2013 growing season. And twenty sampling points were established for the collection of soil samples for soil water and salinity, which were used for calibration of ECa. In addition, plant species, biomass and spatial patterns of vegetation were also sampled. The results showed that ECa maps exhibited distinctly spatial differences because of variations in soil moisture. And soil water was the main factor to drive salinity patterns, which in turn affected ECa values. Moreover, soil water and salinity could explain 82.8% of ECa changes due to there was a significant correlation (P<0.01) between ECa, soil water and salinity. Furthermore, with higher ECa values closer to A. splendens patches at the experimental site, patterns of ECa images showed clearly temporal stability, which were extremely corresponding with the spatial pattern of vegetation. A. splendens patches that accumulated infiltrating water and salinity and thus changed long-term soil properties, which were considered as "reservoirs" and were deemed responsible for the temporal stability of ECa images. Hence, EMI could be an indicator to locate areas of decreasing or increasing of water and to reveal soil water and salinity dynamics through repeated ECa surveys.

Scale dependence of the diversity–stability relationship in a temperate grassland

PubMed Central

Zhang, Yunhai; He, Nianpeng; Loreau, Michel; Pan, Qingmin; Han, Xingguo

2018-01-01

A positive relationship between biodiversity and ecosystem stability has been reported in many ecosystems; however, it has yet to be determined whether and how spatial scale affects this relationship. Here, for the first time, we assessed the effects of alpha, beta and gamma diversity on ecosystem stability and the scale dependence of the slope of the diversity–stability relationship.By employing a long-term (33 years) dataset from a temperate grassland, northern China, we calculated the all possible spatial scales with the complete combination from the basic 1-m2 plots.Species richness was positively associated with ecosystem stability through species asynchrony and overyielding at all spatial scales (1, 2, 3, 4 and 5 m2). Both alpha and beta diversity were positively associated with gamma stability.Moreover, the slope of the diversity–area relationship was significantly higher than that of the stability–area relationship, resulting in a decline of the slope of the diversity–stability relationship with increasing area.Synthesis. With the positive species diversity effect on ecosystem stability from small to large spatial scales, our findings demonstrate the need to maintain a high biodiversity and biotic heterogeneity as insurance against the risks incurred by ecosystems in the face of global environmental changes. PMID:29725139

Phase Distribution and Selection of Partially Correlated Persistent Scatterers

NASA Astrophysics Data System (ADS)

Lien, J.; Zebker, H. A.

2012-12-01

Interferometric synthetic aperture radar (InSAR) time-series methods can effectively estimate temporal surface changes induced by geophysical phenomena. However, such methods are susceptible to decorrelation due to spatial and temporal baselines (radar pass separation), changes in orbital geometries, atmosphere, and noise. These effects limit the number of interferograms that can be used for differential analysis and obscure the deformation signal. InSAR decorrelation effects may be ameliorated by exploiting pixels that exhibit phase stability across the stack of interferograms. These so-called persistent scatterer (PS) pixels are dominated by a single point-like scatterer that remains phase-stable over the spatial and temporal baseline. By identifying a network of PS pixels for use in phase unwrapping, reliable deformation measurements may be obtained even in areas of low correlation, where traditional InSAR techniques fail to produce useful observations. Many additional pixels can be added to the PS list if we are able to identify those in which a dominant scatterer exhibits partial, rather than complete, correlation across all radar scenes. In this work, we quantify and exploit the phase stability of partially correlated PS pixels. We present a new system model for producing interferometric pixel values from a complex surface backscatter function characterized by signal-to-clutter ratio (SCR). From this model, we derive the joint probabilistic distribution for PS pixel phases in a stack of interferograms as a function of SCR and spatial baselines. This PS phase distribution generalizes previous results that assume the clutter phase contribution is uncorrelated between radar passes. We verify the analytic distribution through a series of radar scattering simulations. We use the derived joint PS phase distribution with maximum-likelihood SCR estimation to analyze an area of the Hayward Fault Zone in the San Francisco Bay Area. We obtain a series of 38 interferometric images of the area from C-band ERS radar satellite passes between May 1995 and December 2000. We compare the estimated SCRs to those calculated with previously derived PS phase distributions. Finally, we examine the PS network density resulting from varying selection thresholds of SCR and compare to other PS identification techniques.

Multi-Timescale Analysis of the Spatial Representativeness of In Situ Soil Moisture Data within Satellite Footprints

NASA Astrophysics Data System (ADS)

Molero, B.; Leroux, D. J.; Richaume, P.; Kerr, Y. H.; Merlin, O.; Cosh, M. H.; Bindlish, R.

2018-01-01

We conduct a novel comprehensive investigation that seeks to prove the connection between spatial scales and timescales in surface soil moisture (SM) within the satellite footprint ( 50 km). Modeled and measured point series at Yanco and Little Washita in situ networks are first decomposed into anomalies at timescales ranging from 0.5 to 128 days, using wavelet transforms. Then, their degree of spatial representativeness is evaluated on a per-timescale basis by comparison to large spatial scale data sets (the in situ spatial average, SMOS, AMSR2, and ECMWF). Four methods are used for this: temporal stability analysis (TStab), triple collocation (TC), percentage of correlated areas (CArea), and a new proposed approach that uses wavelet-based correlations (WCor). We found that the mean of the spatial representativeness values tends to increase with the timescale but so does their dispersion. Locations exhibit poor spatial representativeness at scales below 4 days, while either very good or poor representativeness at seasonal scales. Regarding the methods, TStab cannot be applied to the anomaly series due to their multiple zero-crossings, and TC is suitable for week and month scales but not for other scales where data set cross-correlations are found low. In contrast, WCor and CArea give consistent results at all timescales. WCor is less sensitive to the spatial sampling density, so it is a robust method that can be applied to sparse networks (one station per footprint). These results are promising to improve the validation and downscaling of satellite SM series and the optimization of SM networks.

Potential and flux field landscape theory. I. Global stability and dynamics of spatially dependent non-equilibrium systems.

PubMed

Wu, Wei; Wang, Jin

2013-09-28

We established a potential and flux field landscape theory to quantify the global stability and dynamics of general spatially dependent non-equilibrium deterministic and stochastic systems. We extended our potential and flux landscape theory for spatially independent non-equilibrium stochastic systems described by Fokker-Planck equations to spatially dependent stochastic systems governed by general functional Fokker-Planck equations as well as functional Kramers-Moyal equations derived from master equations. Our general theory is applied to reaction-diffusion systems. For equilibrium spatially dependent systems with detailed balance, the potential field landscape alone, defined in terms of the steady state probability distribution functional, determines the global stability and dynamics of the system. The global stability of the system is closely related to the topography of the potential field landscape in terms of the basins of attraction and barrier heights in the field configuration state space. The effective driving force of the system is generated by the functional gradient of the potential field alone. For non-equilibrium spatially dependent systems, the curl probability flux field is indispensable in breaking detailed balance and creating non-equilibrium condition for the system. A complete characterization of the non-equilibrium dynamics of the spatially dependent system requires both the potential field and the curl probability flux field. While the non-equilibrium potential field landscape attracts the system down along the functional gradient similar to an electron moving in an electric field, the non-equilibrium flux field drives the system in a curly way similar to an electron moving in a magnetic field. In the small fluctuation limit, the intrinsic potential field as the small fluctuation limit of the potential field for spatially dependent non-equilibrium systems, which is closely related to the steady state probability distribution functional, is found to be a Lyapunov functional of the deterministic spatially dependent system. Therefore, the intrinsic potential landscape can characterize the global stability of the deterministic system. The relative entropy functional of the stochastic spatially dependent non-equilibrium system is found to be the Lyapunov functional of the stochastic dynamics of the system. Therefore, the relative entropy functional quantifies the global stability of the stochastic system with finite fluctuations. Our theory offers an alternative general approach to other field-theoretic techniques, to study the global stability and dynamics of spatially dependent non-equilibrium field systems. It can be applied to many physical, chemical, and biological spatially dependent non-equilibrium systems.

Spatial impacts of inorganic ligand availability and localized microbial community structure on mitigation of zinc laden mine water in sulfate-reducing bioreactors.

PubMed

Drennan, Dina M; Almstrand, Robert; Ladderud, Jeffrey; Lee, Ilsu; Landkamer, Lee; Figueroa, Linda; Sharp, Jonathan O

2017-05-15

Sulfate-reducing bioreactors (SRBRs) represent a passive, sustainable, and long-term option for mitigating mining influenced water (MIW) during release. Here we investigate spatial zinc precipitation profiles as influenced by substrate differentiation, inorganic ligand availability (inorganic carbon and sulfide), and microbial community structure in pilot-scale SRBR columns fed with sulfate and zinc-rich MIW. Through a combination of aqueous sampling, geochemical digests, electron microscopy and energy-dispersive x-ray spectroscopy, we were able to delineate zones of enhanced zinc removal, identify precipitates of varying stability, and discern the temporal and spatial evolution of zinc, sulfur, and calcium associations. These geochemical insights revealed spatially variable immobilization regimes between SRBR columns that could be further contrasted as a function of labile (alfalfa-dominated) versus recalcitrant (woodchip-dominated) solid-phase substrate content. Both column subsets exhibited initial zinc removal as carbonates; however precipitation in association with labile substrates was more pronounced and dominated by metal-sulfide formation in the upper portions of the down flow columns with micrographs visually suggestive of sphalerite (ZnS). In contrast, a more diffuse and lower mass of zinc precipitation in the presence of gypsum-like precipitates occurred within the more recalcitrant column systems. While removal and sulfide-associated precipitation were spatially variable, whole bacterial community structure (ANOSIM) and diversity estimates were comparatively homogeneous. However, two phyla exhibited a potentially selective relationship with a significant positive correlation between the ratio of Firmicutes to Bacteroidetes and sulfide-bound zinc. Collectively these biogeochemical insights indicate that depths of maximal zinc sulfide precipitation are temporally dynamic, influenced by substrate composition and broaden our understanding of bio-immobilized zinc species, microbial interactions and potential operational and monitoring tools in these types of passive bioreactors. Copyright © 2017 Elsevier Ltd. All rights reserved.

Biodiversity and ecosystem stability across scales in metacommunities

PubMed Central

Wang, Shaopeng; Loreau, Michel

2016-01-01

Although diversity-stability relationships have been extensively studied in local ecosystems, the global biodiversity crisis calls for an improved understanding of these relationships in a spatial context. Here we use a dynamical model of competitive metacommunities to study the relationships between species diversity and ecosystem variability across scales. We derive analytic relationships under a limiting case; these results are extended to more general cases with numerical simulations. Our model shows that, while alpha diversity decreases local ecosystem variability, beta diversity generally contributes to increasing spatial asynchrony among local ecosystems. Consequently, both alpha and beta diversity provide stabilizing effects for regional ecosystems, through local and spatial insurance effects, respectively. We further show that at the regional scale, the stabilizing effect of biodiversity increases as spatial environmental correlation increases. Our findings have important implications for understanding the interactive effects of global environmental changes (e.g. environmental homogenization) and biodiversity loss on ecosystem sustainability at large scales. PMID:26918536

Weight Multispectral Reconstruction Strategy for Enhanced Reconstruction Accuracy and Stability With Cerenkov Luminescence Tomography.

PubMed

Hongbo Guo; Xiaowei He; Muhan Liu; Zeyu Zhang; Zhenhua Hu; Jie Tian

2017-06-01

Cerenkov luminescence tomography (CLT) provides a novel technique for 3-D noninvasive detection of radiopharmaceuticals in living subjects. However, because of the severe scattering of Cerenkov light, the reconstruction accuracy and stability of CLT is still unsatisfied. In this paper, a modified weight multispectral CLT (wmCLT) reconstruction strategy was developed which split the Cerenkov radiation spectrum into several sub-spectral bands and weighted the sub-spectral results to obtain the final result. To better evaluate the property of the wmCLT reconstruction strategy in terms of accuracy, stability and practicability, several numerical simulation experiments and in vivo experiments were conducted and the results obtained were compared with the traditional multispectral CLT (mCLT) and hybrid-spectral CLT (hCLT) reconstruction strategies. The numerical simulation results indicated that wmCLT strategy significantly improved the accuracy of Cerenkov source localization and intensity quantitation and exhibited good stability in suppressing noise in numerical simulation experiments. And the comparison of the results achieved from different in vivo experiments further indicated significant improvement of the wmCLT strategy in terms of the shape recovery of the bladder and the spatial resolution of imaging xenograft tumors. Overall the strategy reported here will facilitate the development of nuclear and optical molecular tomography in theoretical study.

Effects of a cognitive dual task on variability and local dynamic stability in sustained repetitive arm movements using principal component analysis: a pilot study.

PubMed

Longo, Alessia; Federolf, Peter; Haid, Thomas; Meulenbroek, Ruud

2018-06-01

In many daily jobs, repetitive arm movements are performed for extended periods of time under continuous cognitive demands. Even highly monotonous tasks exhibit an inherent motor variability and subtle fluctuations in movement stability. Variability and stability are different aspects of system dynamics, whose magnitude may be further affected by a cognitive load. Thus, the aim of the study was to explore and compare the effects of a cognitive dual task on the variability and local dynamic stability in a repetitive bimanual task. Thirteen healthy volunteers performed the repetitive motor task with and without a concurrent cognitive task of counting aloud backwards in multiples of three. Upper-body 3D kinematics were collected and postural reconfigurations-the variability related to the volunteer's postural change-were determined through a principal component analysis-based procedure. Subsequently, the most salient component was selected for the analysis of (1) cycle-to-cycle spatial and temporal variability, and (2) local dynamic stability as reflected by the largest Lyapunov exponent. Finally, end-point variability was evaluated as a control measure. The dual cognitive task proved to increase the temporal variability and reduce the local dynamic stability, marginally decrease endpoint variability, and substantially lower the incidence of postural reconfigurations. Particularly, the latter effect is considered to be relevant for the prevention of work-related musculoskeletal disorders since reduced variability in sustained repetitive tasks might increase the risk of overuse injuries.

Ionic wave propagation and collision in an excitable circuit model of microtubules

NASA Astrophysics Data System (ADS)

Guemkam Ghomsi, P.; Tameh Berinyoh, J. T.; Moukam Kakmeni, F. M.

2018-02-01

In this paper, we report the propensity to excitability of the internal structure of cellular microtubules, modelled as a relatively large one-dimensional spatial array of electrical units with nonlinear resistive features. We propose a model mimicking the dynamics of a large set of such intracellular dynamical entities as an excitable medium. We show that the behavior of such lattices can be described by a complex Ginzburg-Landau equation, which admits several wave solutions, including the plane waves paradigm. A stability analysis of the plane waves solutions of our dynamical system is conducted both analytically and numerically. It is observed that perturbed plane waves will always evolve toward promoting the generation of localized periodic waves trains. These modes include both stationary and travelling spatial excitations. They encompass, on one hand, localized structures such as solitary waves embracing bright solitons, dark solitons, and bisolitonic impulses with head-on collisions phenomena, and on the other hand, the appearance of both spatially homogeneous and spatially inhomogeneous stationary patterns. This ability exhibited by our array of proteinic elements to display several states of excitability exposes their stunning biological and physical complexity and is of high relevance in the description of the developmental and informative processes occurring on the subcellular scale.

Ionic wave propagation and collision in an excitable circuit model of microtubules.

PubMed

Guemkam Ghomsi, P; Tameh Berinyoh, J T; Moukam Kakmeni, F M

2018-02-01

In this paper, we report the propensity to excitability of the internal structure of cellular microtubules, modelled as a relatively large one-dimensional spatial array of electrical units with nonlinear resistive features. We propose a model mimicking the dynamics of a large set of such intracellular dynamical entities as an excitable medium. We show that the behavior of such lattices can be described by a complex Ginzburg-Landau equation, which admits several wave solutions, including the plane waves paradigm. A stability analysis of the plane waves solutions of our dynamical system is conducted both analytically and numerically. It is observed that perturbed plane waves will always evolve toward promoting the generation of localized periodic waves trains. These modes include both stationary and travelling spatial excitations. They encompass, on one hand, localized structures such as solitary waves embracing bright solitons, dark solitons, and bisolitonic impulses with head-on collisions phenomena, and on the other hand, the appearance of both spatially homogeneous and spatially inhomogeneous stationary patterns. This ability exhibited by our array of proteinic elements to display several states of excitability exposes their stunning biological and physical complexity and is of high relevance in the description of the developmental and informative processes occurring on the subcellular scale.

Stabilization and control of distributed systems with time-dependent spatial domains

NASA Technical Reports Server (NTRS)

Wang, P. K. C.

1990-01-01

This paper considers the problem of the stabilization and control of distributed systems with time-dependent spatial domains. The evolution of the spatial domains with time is described by a finite-dimensional system of ordinary differential equations, while the distributed systems are described by first-order or second-order linear evolution equations defined on appropriate Hilbert spaces. First, results pertaining to the existence and uniqueness of solutions of the system equations are presented. Then, various optimal control and stabilization problems are considered. The paper concludes with some examples which illustrate the application of the main results.

Anomalous diffusion of single metal atoms on a graphene oxide support

DOE PAGES

Furnival, Tom; Leary, Rowan K.; Tyo, Eric C.; ...

2017-04-21

Recent studies of single-atom catalysts open up the prospect of designing exceptionally active and environmentally efficient chemical processes. The stability and durability of such catalysts is governed by the strength with which the atoms are bound to their support and their diffusive behaviour. Here we use aberration-corrected STEM to image the diffusion of single copper adatoms on graphene oxide. As a result, we discover that individual atoms exhibit anomalous diffusion as a result of spatial and energetic disorder inherent in the support, and interpret the origins of this behaviour to develop a physical picture for the surface diffusion of singlemore » metal atoms.« less

New Disulfide-Stabilized Fold Provides Sea Anemone Peptide to Exhibit Both Antimicrobial and TRPA1 Potentiating Properties.

PubMed

Logashina, Yulia A; Solstad, Runar Gjerp; Mineev, Konstantin S; Korolkova, Yuliya V; Mosharova, Irina V; Dyachenko, Igor A; Palikov, Victor A; Palikova, Yulia A; Murashev, Arkadii N; Arseniev, Alexander S; Kozlov, Sergey A; Stensvåg, Klara; Haug, Tor; Andreev, Yaroslav A

2017-04-29

A novel bioactive peptide named τ-AnmTx Ueq 12-1 (short name Ueq 12-1) was isolated and characterized from the sea anemone Urticina eques. Ueq 12-1 is unique among the variety of known sea anemone peptides in terms of its primary and spatial structure. It consists of 45 amino acids including 10 cysteine residues with an unusual distribution and represents a new group of sea anemone peptides. The 3D structure of Ueq 12-1, determined by NMR spectroscopy, represents a new disulfide-stabilized fold partly similar to the defensin-like fold. Ueq 12-1 showed the dual activity of both a moderate antibacterial activity against Gram-positive bacteria and a potentiating activity on the transient receptor potential ankyrin 1 (TRPA1). Ueq 12-1 is a unique peptide potentiator of the TRPA1 receptor that produces analgesic and anti-inflammatory effects in vivo . The antinociceptive properties allow us to consider Ueq 12-1 as a potential analgesic drug lead with antibacterial properties.

Drebrin-like protein DBN-1 is a sarcomere component that stabilizes actin filaments during muscle contraction.

PubMed

Butkevich, Eugenia; Bodensiek, Kai; Fakhri, Nikta; von Roden, Kerstin; Schaap, Iwan A T; Majoul, Irina; Schmidt, Christoph F; Klopfenstein, Dieter R

2015-07-06

Actin filament organization and stability in the sarcomeres of muscle cells are critical for force generation. Here we identify and functionally characterize a Caenorhabditis elegans drebrin-like protein DBN-1 as a novel constituent of the muscle contraction machinery. In vitro, DBN-1 exhibits actin filament binding and bundling activity. In vivo, DBN-1 is expressed in body wall muscles of C. elegans. During the muscle contraction cycle, DBN-1 alternates location between myosin- and actin-rich regions of the sarcomere. In contracted muscle, DBN-1 is accumulated at I-bands where it likely regulates proper spacing of α-actinin and tropomyosin and protects actin filaments from the interaction with ADF/cofilin. DBN-1 loss of function results in the partial depolymerization of F-actin during muscle contraction. Taken together, our data show that DBN-1 organizes the muscle contractile apparatus maintaining the spatial relationship between actin-binding proteins such as α-actinin, tropomyosin and ADF/cofilin and possibly strengthening actin filaments by bundling.

Chapter 15: Potential Surprises: Compound Extremes and Tipping Elements

NASA Technical Reports Server (NTRS)

Kopp, R. E.; Hayhoe, K.; Easterling, D. R.; Hall, T.; Horton, R.; Kunkel, K. E.; LeGrande, A. N.

2017-01-01

The Earth system is made up of many components that interact in complex ways across a broad range of temporal and spatial scales. As a result of these interactions the behavior of the system cannot be predicted by looking at individual components in isolation. Negative feedbacks, or self-stabilizing cycles, within and between components of the Earth system can dampen changes (Ch. 2: Physical Drivers of Climate Change). However, their stabilizing effects render such feedbacks of less concern from a risk perspective than positive feedbacks, or self-reinforcing cycles. Positive feedbacks magnify both natural and anthropogenic changes. Some Earth system components, such as arctic sea ice and the polar ice sheets, may exhibit thresholds beyond which these self-reinforcing cycles can drive the component, or the entire system, into a radically different state. Although the probabilities of these state shifts may be difficult to assess, their consequences could be high, potentially exceeding anything anticipated by climate model projections for the coming century.

Intracellular determinants of hippocampal CA1 place and silent cell activity in a novel environment

PubMed Central

Epsztein, Jérôme; Brecht, Michael; Lee, Albert K.

2011-01-01

Summary For each environment a rodent has explored, its hippocampus contains a map consisting of a unique subset of neurons, called place cells, that have spatially-tuned spiking there, with the remaining neurons being essentially silent. Using whole-cell recording in freely moving rats exploring a novel maze, we observed differences in intrinsic cellular properties and input-based subthreshold membrane potential levels underlying this division into place and silent cells. Compared to silent cells, place cells had lower spike thresholds and peaked versus flat subthreshold membrane potentials as a function of animal location. Both differences were evident from the beginning of exploration. Additionally, future place cells exhibited higher burst propensity before exploration. Thus, internal settings appear to predetermine which cells will represent the next novel environment encountered. Furthermore, place cells fired spatially-tuned bursts with large, putatively calcium-mediated depolarizations that could trigger plasticity and stabilize the new map for long-term storage. Our results provide new insight into hippocampal memory formation. PMID:21482360

Quantitative assessment of neural outgrowth using spatial light interference microscopy

NASA Astrophysics Data System (ADS)

Lee, Young Jae; Cintora, Pati; Arikkath, Jyothi; Akinsola, Olaoluwa; Kandel, Mikhail; Popescu, Gabriel; Best-Popescu, Catherine

2017-06-01

Optimal growth as well as branching of axons and dendrites is critical for the nervous system function. Neuritic length, arborization, and growth rate determine the innervation properties of neurons and define each cell's computational capability. Thus, to investigate the nervous system function, we need to develop methods and instrumentation techniques capable of quantifying various aspects of neural network formation: neuron process extension, retraction, stability, and branching. During the last three decades, fluorescence microscopy has yielded enormous advances in our understanding of neurobiology. While fluorescent markers provide valuable specificity to imaging, photobleaching, and photoxicity often limit the duration of the investigation. Here, we used spatial light interference microscopy (SLIM) to measure quantitatively neurite outgrowth as a function of cell confluence. Because it is label-free and nondestructive, SLIM allows for long-term investigation over many hours. We found that neurons exhibit a higher growth rate of neurite length in low-confluence versus medium- and high-confluence conditions. We believe this methodology will aid investigators in performing unbiased, nondestructive analysis of morphometric neuronal parameters.

The Relationship Between Postural and Movement Stability.

PubMed

Feldman, Anatol G

2016-01-01

Postural stabilization is provided by stretch reflexes, intermuscular reflexes, and intrinsic muscle properties. Taken together, these posture-stabilizing mechanisms resist deflections from the posture at which balance of muscle and external forces is maintained. Empirical findings suggest that for each muscle, these mechanisms become functional at a specific, spatial threshold-the muscle length or respective joint angle at which motor units begin to be recruited. Empirical data suggest that spinal and supraspinal centers can shift the spatial thresholds for a group of muscles that stabilized the initial posture. As a consequence, the same stabilizing mechanisms, instead of resisting motion from the initial posture, drive the body to another stable posture. In other words by shifting spatial thresholds, the nervous system converts movement resisting to movement-producing mechanisms. It is illustrated that, contrary to conventional view, this control strategy allows the system to transfer body balance to produce locomotion and other actions without loosing stability at any point of them. It also helps orient posture and movement with the direction of gravity. It is concluded that postural and movement stability is provided by a common mechanism.

Revisiting the Stability of Spatially Heterogeneous Predator-Prey Systems Under Eutrophication.

PubMed

Farkas, J Z; Morozov, A Yu; Arashkevich, E G; Nikishina, A

2015-10-01

We employ partial integro-differential equations to model trophic interaction in a spatially extended heterogeneous environment. Compared to classical reaction-diffusion models, this framework allows us to more realistically describe the situation where movement of individuals occurs on a faster time scale than on the demographic (population) time scale, and we cannot determine population growth based on local density. However, most of the results reported so far for such systems have only been verified numerically and for a particular choice of model functions, which obviously casts doubts about these findings. In this paper, we analyse a class of integro-differential predator-prey models with a highly mobile predator in a heterogeneous environment, and we reveal the main factors stabilizing such systems. In particular, we explore an ecologically relevant case of interactions in a highly eutrophic environment, where the prey carrying capacity can be formally set to 'infinity'. We investigate two main scenarios: (1) the spatial gradient of the growth rate is due to abiotic factors only, and (2) the local growth rate depends on the global density distribution across the environment (e.g. due to non-local self-shading). For an arbitrary spatial gradient of the prey growth rate, we analytically investigate the possibility of the predator-prey equilibrium in such systems and we explore the conditions of stability of this equilibrium. In particular, we demonstrate that for a Holling type I (linear) functional response, the predator can stabilize the system at low prey density even for an 'unlimited' carrying capacity. We conclude that the interplay between spatial heterogeneity in the prey growth and fast displacement of the predator across the habitat works as an efficient stabilizing mechanism. These results highlight the generality of the stabilization mechanisms we find in spatially structured predator-prey ecological systems in a heterogeneous environment.

Stable functional networks exhibit consistent timing in the human brain.

PubMed

Chapeton, Julio I; Inati, Sara K; Zaghloul, Kareem A

2017-03-01

Despite many advances in the study of large-scale human functional networks, the question of timing, stability, and direction of communication between cortical regions has not been fully addressed. At the cellular level, neuronal communication occurs through axons and dendrites, and the time required for such communication is well defined and preserved. At larger spatial scales, however, the relationship between timing, direction, and communication between brain regions is less clear. Here, we use a measure of effective connectivity to identify connections between brain regions that exhibit communication with consistent timing. We hypothesized that if two brain regions are communicating, then knowledge of the activity in one region should allow an external observer to better predict activity in the other region, and that such communication involves a consistent time delay. We examine this question using intracranial electroencephalography captured from nine human participants with medically refractory epilepsy. We use a coupling measure based on time-lagged mutual information to identify effective connections between brain regions that exhibit a statistically significant increase in average mutual information at a consistent time delay. These identified connections result in sparse, directed functional networks that are stable over minutes, hours, and days. Notably, the time delays associated with these connections are also highly preserved over multiple time scales. We characterize the anatomic locations of these connections, and find that the propagation of activity exhibits a preferred posterior to anterior temporal lobe direction, consistent across participants. Moreover, networks constructed from connections that reliably exhibit consistent timing between anatomic regions demonstrate features of a small-world architecture, with many reliable connections between anatomically neighbouring regions and few long range connections. Together, our results demonstrate that cortical regions exhibit functional relationships with well-defined and consistent timing, and the stability of these relationships over multiple time scales suggests that these stable pathways may be reliably and repeatedly used for large-scale cortical communication. Published by Oxford University Press on behalf of the Guarantors of Brain 2017. This work is written by US Government employees and is in the public domain in the United States.

Strain-Mediated Modification of Phagraphene Dirac Cones

DOE PAGES

Lopez-Bezanilla, Alejandro

2016-07-07

We present a first-principles study on the electronic and dynamical properties of phagraphene [Nano Lett., 2015, 15 (9), pp 6182]. This carbon allotrope exhibits a square unit cell, Dirac cones, and robustness against uniaxial deformation. By analyzing the contribution of each carbon atom orbital in the formation of the electronic states, we conclude that only the pz orbitals of eight out of the twenty atoms in the square unit cell are responsible of the formation of the nano-structure Dirac cones. Spatial symmetry breaking of the underlying honeycomb-like network upon shear stress application leads to a band gap opening. The analysismore » of the phonon spectra demonstrates that the dynamical stability of phagraphene is guaranteed for small distortion angles. Phagraphene is identified here as the first all-C graphitic monolayer with Dirac cones modifiable by a small and realistic physical deformation. The analysis and conclusions of this study can be applied to other monolayered materials exhibiting Dirac cones in square lattices.« less

Stability and spatial arrangement of the 2,4-dichlorophenoxyacetic acid and β-cyclodextrin inclusion compound: A theoretical study

NASA Astrophysics Data System (ADS)

Pereira, Robson A.; Anconi, Cleber P. A.; Nascimento, Clebio S.; De Almeida, Wagner B.; Dos Santos, Hélio F.

2015-07-01

The present letter reports results from a comprehensive theoretical analysis of the inclusion process involving 2,4-dichlorophenoxyacetic acid (2,4-D) and β-cyclodextrin (β-CD) for which the experimental data of formation is available. Spatial arrangement and stabilization energies were evaluated in gas phase and aqueous solution through density functional theory (DFT) and through the use of SMD implicit solvation approach. The discussed methodology was applied to predict the stability and identify the most favorable form (deprotonated or neutral) as well as the most probable spatial arrangement of the studied inclusion compound.

Posture, head stability, and orientation recovery during vestibular regeneration in pigeons.

PubMed

Dickman, J David; Lim, Insook

2004-09-01

Compensatory behavior such as oculomotor, gaze, and postural responses that occur during movement largely depend upon a functioning vestibular system. In the present study, the initial loss and subsequent recovery of postural and head stability in pigeons undergoing vestibular regeneration were examined. Adult pigeons were trained to manipulate a straight run chamber to peck an illuminated key for fluid reward. Six behavioral measures assessing performance, posture, and head stability were quantified. These included run latency, steps (walking), path negotiation (lane changes), gaze saccades, head bobs, and head shakes. Once normative values were obtained for four birds, complete lesion of all receptor cells and denervation of the epithelia in the vestibular endorgans were produced using a single intralabyrinthine application of streptomycin sulfate. Each bird was then tested at specific times during regeneration and the same behavioral measures examined. At 7 days post-streptomycin treatment (PST), all birds exhibited severe postural and head instability, with tremors, head shakes, staggering, and circling predominating. No normal trial runs, walking, gaze saccades, or head bobs were present. Many of these dysfunctions persisted through 3-4 weeks PST. Gradually, tremor and head shakes diminished and were replaced with an increasing number of normal head bobs during steps and gaze saccades. Beginning at 4 weeks PST, but largely inaccurate, was the observed initiation of directed steps, less staggering, and some successful path negotiation. As regeneration progressed, spatial orientation and navigation ability increased and, by 49 days PST, most trials were successful. By 70 days PST, all birds had recovered to pretreatment levels. Thus, it was observed that ataxia must subside, coincident with normalized head and postural stability prior to the recovery of spatial orientation and path navigation recovery. Parallels in recovery were drawn to hair cell regeneration and afferent responsiveness, as inferred from present results and those in other investigations.

Spatial Cues Provided by Sound Improve Postural Stabilization: Evidence of a Spatial Auditory Map?

PubMed Central

Gandemer, Lennie; Parseihian, Gaetan; Kronland-Martinet, Richard; Bourdin, Christophe

2017-01-01

It has long been suggested that sound plays a role in the postural control process. Few studies however have explored sound and posture interactions. The present paper focuses on the specific impact of audition on posture, seeking to determine the attributes of sound that may be useful for postural purposes. We investigated the postural sway of young, healthy blindfolded subjects in two experiments involving different static auditory environments. In the first experiment, we compared effect on sway in a simple environment built from three static sound sources in two different rooms: a normal vs. an anechoic room. In the second experiment, the same auditory environment was enriched in various ways, including the ambisonics synthesis of a immersive environment, and subjects stood on two different surfaces: a foam vs. a normal surface. The results of both experiments suggest that the spatial cues provided by sound can be used to improve postural stability. The richer the auditory environment, the better this stabilization. We interpret these results by invoking the “spatial hearing map” theory: listeners build their own mental representation of their surrounding environment, which provides them with spatial landmarks that help them to better stabilize. PMID:28694770

Controlling the stability of nonlinear optical modes via electromagnetically induced transparency

NASA Astrophysics Data System (ADS)

Zhang, Kun; Liang, Yi-zeng; Lin, Ji; Li, Hui-jun

2018-02-01

We propose a scheme to generate and stabilize the high-dimensional spatial solitons via electromagnetically induced transparency (EIT). The system we consider is a resonant atomic ensemble having Λ configuration. We illustrate that under EIT conditions the equation satisfied by the probe field envelope is reduced to a saturable nonlinear Schrödinger equation with the trapping potential, provided by a far-detuned laser field and a random magnetic field. We present high-dimensional soliton solutions exhibiting many interesting characteristics, including diversity (i.e., many different types of soliton solutions can be found, including bright, ring multipole bright, ring multipole defect mode, multiring bright, multiring defect mode, and vortices solitons), the phase transition between bright soliton and higher-order defect modes (i.e., the phase transition can be realized by controlling the nonlinear coefficient or the intensity of the trapping potential), and stability (i.e., various solitons can be stabilized by the Gaussian potential provided by the far detuned laser field, or the random potential provided by the magnetic field). We also find that some solitons are the extension of the linear eigenmode, whereas others entirely derive from the role of nonlinearity. Compared with previous studies, we not only show the diverse soliton solutions in the same system but also find the boundary of the phase transition for the type of solitons. In addition, we present the possibility of using the random potential to stabilize various solitons and vortices.

A DNS study on the stabilization mechanism of a turbulent lifted ethylene jet flame in highly-heated coflow

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yoo, Chun S

2011-01-01

Direct numerical simulation (DNS) of the near-field of a three-dimensional spatially-developing turbulent ethylene jet flame in highly-heated coflow is performed with a reduced mechanism to determine the stabilization mechanism. The DNS was performed at a jet Reynolds number of 10,000 with over 1.29 billion grid points. The results show that auto-ignition in a fuel-lean mixture at the flame base is the main source of stabilization of the lifted jet flame. The Damkoehler number and chemical explosive mode (CEM) analysis also verify that auto-ignition occurs at the flame base. In addition to auto-ignition, Lagrangian tracking of the flame base reveals themore » passage of large-scale flow structures and their correlation with the fluctuations of the flame base similar to a previous study (Yoo et al., J. Fluid Mech. 640 (2009) 453-481) with hydrogen/air jet flames. It is also observed that the present lifted flame base exhibits a cyclic 'saw-tooth' shaped movement marked by rapid movement upstream and slower movement downstream. This is a consequence of the lifted flame being stabilized by a balance between consecutive auto-ignition events in hot fuel-lean mixtures and convection induced by the high-speed jet and coflow velocities. This is confirmed by Lagrangian tracking of key variables including the flame-normal velocity, displacement speed, scalar dissipation rate, and mixture fraction at the stabilization point.« less

A DNS study on the stabilization mechanism of a turbulent lifted ethylene jet flame in highly-heated coflow

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yoo, C. S.; Richardson, E.; Sankaran, R.

2011-01-01

Direct numerical simulation (DNS) of the near-field of a three-dimensional spatially-developing turbulent ethylene jet flame in highly-heated coflow is performed with a reduced mechanism to determine the stabilization mechanism. The DNS was performed at a jet Reynolds number of 10,000 with over 1.29 billion grid points. The results show that auto-ignition in a fuel-lean mixture at the flame base is the main source of stabilization of the lifted jet flame. The Damköhler number and chemical explosive mode (CEM) analysis also verify that auto-ignition occurs at the flame base. In addition to auto-ignition, Lagrangian tracking of the flame base reveals themore » passage of large-scale flow structures and their correlation with the fluctuations of the flame base similar to a previous study (Yoo et al., J. Fluid Mech. 640 (2009) 453–481) with hydrogen/air jet flames. It is also observed that the present lifted flame base exhibits a cyclic ‘saw-tooth’ shaped movement marked by rapid movement upstream and slower movement downstream. This is a consequence of the lifted flame being stabilized by a balance between consecutive auto-ignition events in hot fuel-lean mixtures and convection induced by the high-speed jet and coflow velocities. This is confirmed by Lagrangian tracking of key variables including the flame-normal velocity, displacement speed, scalar dissipation rate, and mixture fraction at the stabilization point.« less

Species dispersal rates alter diversity and ecosystem stability in pond metacommunities.

PubMed

Howeth, Jennifer G; Leibold, Mathew A

2010-09-01

Metacommunity theory suggests that relationships between diversity and ecosystem stability can be determined by the rate of species dispersal among local communities. The predicted relationships, however, may depend upon the relative strength of local environmental processes and disturbance. Here we evaluate the role of dispersal frequency and local predation perturbations in affecting patterns of diversity and stability in pond plankton metacommunities. Pond metacommunities were composed of three mesocosm communities: one of the three communities maintained constant "press" predation from a selective predator, bluegill sunfish (Lepomis macrochirus); the second community maintained "press" conditions without predation; and the third community experienced recurrent "pulsed" predation from bluegill sunfish. The triads of pond communities were connected at either no, low (0.7%/d), or high (20%/d) planktonic dispersal. Richness and composition of zooplankton and stability of plankton biomass and ecosystem productivity were measured at local and regional spatial scales. Dispersal significantly affected diversity such that local and regional biotas at the low dispersal rate maintained the greatest number of species. The unimodal local dispersal-diversity relationship was predator-dependent, however, as selective press predation excluded species regardless of dispersal. Further, there was no effect of dispersal on beta diversity because predation generated local conditions that selected for distinct community assemblages. Spatial and temporal ecosystem stability responded to dispersal frequency but not predation. Low dispersal destabilized the spatial stability of producer biomass but stabilized temporal ecosystem productivity. The results indicate that selective predation can prevent species augmentation from mass effects but has no apparent influence on stability. Dispersal rates, in contrast, can have significant effects on both species diversity and ecosystem stability at multiple spatial scales in metacommunities.

Dynamic stability and bifurcation analysis in fractional thermodynamics

NASA Astrophysics Data System (ADS)

Béda, Péter B.

2018-02-01

In mechanics, viscoelasticity was the first field of applications in studying geomaterials. Further possibilities arise in spatial non-locality. Non-local materials were already studied in the 1960s by several authors as a part of continuum mechanics and are still in focus of interest because of the rising importance of materials with internal micro- and nano-structure. When material instability gained more interest, non-local behavior appeared in a different aspect. The problem was concerned to numerical analysis, because then instability zones exhibited singular properties for local constitutive equations. In dynamic stability analysis, mathematical aspects of non-locality were studied by using the theory of dynamic systems. There the basic set of equations describing the behavior of continua was transformed to an abstract dynamic system consisting of differential operators acting on the perturbation field variables. Such functions should satisfy homogeneous boundary conditions and act as indicators of stability of a selected state of the body under consideration. Dynamic systems approach results in conditions for cases, when the differential operators have critical eigenvalues of zero real parts (dynamic stability or instability conditions). When the critical eigenvalues have non-trivial eigenspace, the way of loss of stability is classified as a typical (or generic) bifurcation. Our experiences show that material non-locality and the generic nature of bifurcation at instability are connected, and the basic functions of the non-trivial eigenspace can be used to determine internal length quantities of non-local mechanics. Fractional calculus is already successfully used in thermo-elasticity. In the paper, non-locality is introduced via fractional strain into the constitutive relations of various conventional types. Then, by defining dynamic systems, stability and bifurcation are studied for states of thermo-mechanical solids. Stability conditions and genericity conditions are presented for constitutive relations under consideration.

Kinetic measures of restabilisation during volitional stepping reveal age-related alterations in the control of mediolateral dynamic stability.

PubMed

Singer, Jonathan C; McIlroy, William E; Prentice, Stephen D

2014-11-07

Research examining age-related changes in dynamic stability during stepping has recognised the importance of the restabilisation phase, subsequent to foot-contact. While regulation of the net ground reaction force (GRFnet) line of action is believed to influence dynamic stability during steady-state locomotion, such control during restabilisation remains unknown. This work explored the origins of age-related decline in mediolateral dynamic stability by examining the line of action of GRFnet relative to the centre of mass (COM) during restabilisation following voluntary stepping. Healthy younger and older adults (n=20 per group) performed three single-step tasks (varying speed and step placement), altering the challenge to stability control. Age-related differences in magnitude and intertrial variability of the angle of divergence of GRFnet line of action relative to the COM were quantified, along with the peak mediolateral and vertical GRFnet components. The angle of divergence was further examined at discrete points during restabilisation, to uncover events of potential importance to stability control. Older adults exhibited a reduced angle of divergence throughout restabilisation. Temporal and spatial constraints on stepping increased the magnitude and intertrial variability of the angle of divergence, although not differentially among the older adults. Analysis of the time-varying angle of divergence revealed age-related reductions in magnitude, with increases in timing and intertrial timing variability during the later phase of restabilisation. This work further supports the idea that age-related challenges in lateral stability control emerge during restabilisation. Age-related alterations during the later phase of restabilisation may signify challenges with reactive control. Copyright © 2014 Elsevier Ltd. All rights reserved.

The stability and slow dynamics of spot patterns in the 2D Brusselator model: The effect of open systems and heterogeneities

NASA Astrophysics Data System (ADS)

Tzou, J. C.; Ward, M. J.

2018-06-01

Spot patterns, whereby the activator field becomes spatially localized near certain dynamically-evolving discrete spatial locations in a bounded multi-dimensional domain, is a common occurrence for two-component reaction-diffusion (RD) systems in the singular limit of a large diffusivity ratio. In previous studies of 2-D localized spot patterns for various specific well-known RD systems, the domain boundary was assumed to be impermeable to both the activator and inhibitor, and the reaction-kinetics were assumed to be spatially uniform. As an extension of this previous theory, we use formal asymptotic methods to study the existence, stability, and slow dynamics of localized spot patterns for the singularly perturbed 2-D Brusselator RD model when the domain boundary is only partially impermeable, as modeled by an inhomogeneous Robin boundary condition, or when there is an influx of inhibitor across the domain boundary. In our analysis, we will also allow for the effect of a spatially variable bulk feed term in the reaction kinetics. By applying our extended theory to the special case of one-spot patterns and ring patterns of spots inside the unit disk, we provide a detailed analysis of the effect on spot patterns of these three different sources of heterogeneity. In particular, when there is an influx of inhibitor across the boundary of the unit disk, a ring pattern of spots can become pinned to a ring-radius closer to the domain boundary. Under a Robin condition, a quasi-equilibrium ring pattern of spots is shown to exhibit a novel saddle-node bifurcation behavior in terms of either the inhibitor diffusivity, the Robin constant, or the ambient background concentration. A spatially variable bulk feed term, with a concentrated source of "fuel" inside the domain, is shown to yield a saddle-node bifurcation structure of spot equilibria, which leads to qualitatively new spot-pinning behavior. Results from our asymptotic theory are validated from full numerical simulations of the Brusselator model.

Spatial Patterns of Plant Litter and Sedimentation in a Tidal Freshwater Marsh and Implications for Marsh Persistence

NASA Astrophysics Data System (ADS)

Elmore, A. J.; Cadol, D. D.; Palinkas, C. M.; Engelhardt, K. A.

2014-12-01

The maintenance of marsh platform elevation under sea level rise is dependent on sedimentation and biomass conversion to soil organic material. These physical and biological processes interact within the tidal zone, resulting in elevation-dependent processes contributing to marsh accretion. Here we explore spatial pattern in plant litter, a variable related to productivity, to understand its role in physical and biological interactions in a freshwater marsh. Plant litter that persists through the dormant season has an extended period of influence on ecosystem processes. We conducted a field and remote sensing analysis of plant litter height, biomass, vertical cover, and stem density (collectively termed plant litter structure) at a tidal freshwater marsh located along the Potomac River estuary. We completed two years of repeat RTK GPS surveys with corresponding measurements of litter height (over 2000 observations) to train a non-parametric random forest decision tree to predict litter height. LiDAR and field observations show that plant litter height increases with increasing elevation, although important deviations from this relationship are apparent. These spatial patterns exhibit stability from year to year and lead to corresponding patterns in soil organic matter content, revealed by loss on ignition of surface sediments. The amount of mineral material embedded within plant litter decreases with increasing elevation, representing an important trade-off with litter structure. Therefore, at low elevations where litter structure is short and sparse, the role of plant litter is to capture sediment; at high elevations where litter structure is tall and dense, litter contributes organic matter to soil development. Despite these tradeoffs, changes in elevation over time are consistent across elevation, with only small positive differences in elevation gain over time at elevations where the most sediment is deposited or where litter exhibits the most biomass.

Spin Structures and Phase Diagrams of Extended Spatially Completely Anisotropic Triangular Lattice Antiferromagnets

NASA Astrophysics Data System (ADS)

Sakakida, Keishiro; Shimahara, Hiroshi

2017-12-01

Motivated by recently discovered organic antiferromagnets, we examine an extended triangular lattice that consists of two types of triangles of bonds with exchange coupling constants Jℓ and J'ℓ (ℓ= 1, 2, and 3), respectively. The simplified system with Jℓ = J'ℓ > 0 is the spatially completely anisotropic triangular lattice (SCATL) antiferromagnet examined previously. The extended system, which we call an extended SCATL (ESCATL), has two different spatial anisotropy parameters J3/J2 and J'3/J'2 when J1 = J'1 is assumed. We derive classical phase diagrams and spin structures. It is found that the ESCATL antiferromagnet exhibits two up-up-down-down (uudd) phases when the imbalance of the anisotropy parameters is significant, in addition to the three Néel phases that occur in the SCATL. When the model parameters vary, these collinear phases are continuously connected by the spiral-spin phase. Using the available model parameters for the organic compounds λ-(BETS)2XCl4 (X = Fe and Ga), we examine the stabilities of the spin structures of the independent π-electron system, which is considered to primarily sustain the magnetic order, where BETS represents bis(ethylenedithio)tetraselenafulvalene. It is found that one of the uudd phases has an energy close to the ground-state energy for λ-(BETS)2FeCl4. We discuss the relevance of the magnetic anion FeCl4 and the quantum fluctuation to the magnetism of these compounds. When J'3 = 0, the system is reduced to a trellis lattice antiferromagnet. The system exhibits a stripe spiral-spin phase, which comprises one-dimensional spiral-spin states stacked alternately.

Spatially varying geometric phase in classically entangled vector beams of light

NASA Astrophysics Data System (ADS)

King-Smith, Andrew; Leary, Cody

We present theoretical results describing a spatially varying geometric (Pancharatnam) phase present in vector modes of light, in which the polarization and transverse spatial mode degrees of freedom exhibit classical entanglement. We propose an experimental setup capable of characterizing this effect, in which a vector mode propagates through a Mach-Zehnder interferometer with a birefringent phase retarder present in one arm. Since the polarization state of a classically entangled light beam exhibits spatial variation across the transverse mode profile, the phase retarder gives rise to a spatially varying geometric phase in the beam propagating through it. When recombined with the reference beam from the other interferometer arm, the presence of the geometric phase is exhibited in the resulting interference pattern. We acknowledge funding from the Research Corporation for Science Advancement by means of a Cottrell College Science Award.

Mitotic accumulation of dimethylated lysine 79 of histone H3 is important for maintaining genome integrity during mitosis in human cells.

PubMed

Guppy, Brent J; McManus, Kirk J

2015-02-01

The loss of genome stability is an early event that drives the development and progression of virtually all tumor types. Recent studies have revealed that certain histone post-translational modifications exhibit dynamic and global increases in abundance that coincide with mitosis and exhibit essential roles in maintaining genomic stability. Histone H2B ubiquitination at lysine 120 (H2Bub1) is regulated by RNF20, an E3 ubiquitin ligase that is altered in many tumor types. Through an evolutionarily conserved trans-histone pathway, H2Bub1 is an essential prerequisite for subsequent downstream dimethylation events at lysines 4 (H3K4me2) and 79 (H3K79me2) of histone H3. Although the role that RNF20 plays in tumorigenesis has garnered much attention, the downstream components of the trans-histone pathway, H3K4me2 and H3K79me2, and their potential contributions to genome stability remain largely overlooked. In this study, we employ single-cell imaging and biochemical approaches to investigate the spatial and temporal patterning of RNF20, H2Bub1, H3K4me2, and H3K79me2 throughout the cell cycle, with a particular focus on mitosis. We show that H2Bub1, H3K4me2, and H3K79me2 exhibit distinct temporal progression patterns throughout the cell cycle. Most notably, we demonstrate that H3K79me2 is a highly dynamic histone post-translational modification that reaches maximal abundance during mitosis in an H2Bub1-independent manner. Using RNAi and chemical genetic approaches, we identify DOT1L as a histone methyltransferase required for the mitotic-associated increases in H3K79me2. We also demonstrate that the loss of mitotic H3K79me2 levels correlates with increases in chromosome numbers and increases in mitotic defects. Collectively, these data suggest that H3K79me2 dynamics during mitosis are normally required to maintain genome stability and further implicate the loss of H3K79me2 during mitosis as a pathogenic event that contributes to the development and progression of tumors. Copyright © 2015 by the Genetics Society of America.

Directional reflectance factors for monitoring spatial changes in soil surface structure and soil organic matter erosion in agricultural systems

NASA Astrophysics Data System (ADS)

Croft, H.; Anderson, K.

2012-04-01

Soils can experience rapid structural degradation in response to land cover changes, resulting in reduced soil productivity, increased erodibility and a loss of soil organic matter (SOM). The breakdown of soil aggregates through slaking and raindrop impact is linked to organic matter turnover, with subsequently eroded material often displaying proportionally more SOM. A reduction in aggregate stability is reflected in a decline in soil surface roughness (SSR), indicating that a soil structural change can be used to highlight soil vulnerability to SOM loss through mineralisation or erosion. Accurate, spatially-continuous measurements of SSR are therefore needed at a variety of spatial and temporal scales to understand the spatial nature of SOM erosion and deposition. Remotely-sensed data can provide a cost-effective means of monitoring changes in soil surface condition over broad spatial extents. Previous work has demonstrated the ability of directional reflectance factors to monitor soil crusting within a controlled laboratory experiment, due to changes in the levels of self-shadowing effects by soil aggregates. However, further research is needed to test this approach in situ, where other soil variables may affect measured reflectance factors and to investigate the use of directional reflectance factors for monitoring soil erosion processes. This experiment assesses the potential of using directional reflectance factors to monitor changes in SSR, aggregate stability and soil organic carbon (SOC) content for two agricultural conditions. Five soil plots representing tilled and seedbed soils were subjected to different durations of natural rainfall, producing a range of different levels of SSR. Directional reflectance factors were measured concomitantly with sampling for soil structural and biochemical tests at each soil plot. Soil samples were taken to measure aggregate stability (wet sieving), SOC (loss on ignition) and soil moisture (gravimetric method). SSM values varied from 8.70 to 20.05% and SOC from 1.33 to 1.05%, across all soil plots. Each plot was characterised using a close-range laser scanning device with a 2 mm sampling interval. The point laser data were geostatistically analysed to provide a spatially-distributed measure of SSR, giving sill variance values from 3.15 to 22.99. Reflectance factors from the soil states were measured using a ground-based hyperspectral spectroradiometer (400-2500 nm) attached to an A-frame device. This method allowed measurement at a range of viewing zenith angles from extreme forwardscatter (-60°) to extreme backscatter (+60°) at a 10° sampling resolution in the solar principal plane. Reflectance measurements were compared to geostatistically-derived indicators of SSR from the laser profile data. Forward-scattered reflectance factors exhibited a very strong relationship to SSR (R2 = 0.84 at -60°; p< 0.05), demonstrating the operational potential of directional reflectance for providing SSR measurements, despite conflicting variation in SSM. SSM also presented an interesting directional signal (R2 = 0.99 at +20°; p< 0.01). Furthermore, the results showed an important link between SRR decline as measured using directional reflectance, with a decline in aggregate stability and SOC content. These findings provide an empirical and theoretical basis for the future retrieval of spatially-continuous assessments of soil surface structure and carbon turnover within a landscape context.

Non Lyapunov stability of a constant spatially developing 2-D gas flow

NASA Astrophysics Data System (ADS)

Balint, Agneta M.; Balint, Stefan; Tanasie, Loredana

2017-01-01

Different types of stabilities (global, local) and instabilities (global absolute, local convective) of the constant spatially developing 2-D gas flow are analyzed in a particular phase space of continuously differentiable functions, endowed with the usual algebraic operations and the topology generated by the uniform convergence on the plane. For this purpose the Euler equations linearized at the constant flow are used. The Lyapunov stability analysis was presented in [1] and this paper is a continuation of [1].

Existence and Stability of Spatial Plane Waves for the Incompressible Navier-Stokes in R^3

NASA Astrophysics Data System (ADS)

Correia, Simão; Figueira, Mário

2018-03-01

We consider the three-dimensional incompressible Navier-Stokes equation on the whole space. We observe that this system admits a L^∞ family of global spatial plane wave solutions, which are connected with the two-dimensional equation. We then proceed to prove local well-posedness over a space which includes L^3(R^3) and these solutions. Finally, we prove L^3-stability of spatial plane waves, with no condition on their size.

Biomonitoring approach with mussel Mytilus galloprovincialis (Lmk) and clam Ruditapes philippinarum (Adams and Reeve, 1850) in the Lagoon of Venice.

PubMed

Moschino, Vanessa; Delaney, Eugenia; Meneghetti, Francesca; Ros, Luisa Da

2011-06-01

Transplanted Mytilus galloprovincialis and native Ruditapes philippinarum were deployed in 10 sampling stations with different pollution impact within the Lagoon of Venice to evaluate the temporal variations and the suitability of the following cytochemical and histochemical biomarkers just as indicators of environmental stress: lysosomal membrane stability, lipofuscins, neutral lipids and lysosome to cytoplasm volume ratio. The physiological status of the organisms was also investigated by determining the survival in air capability and the reburrowing rate (clams). The biological parameters were assessed in June and October. Furthermore, for a better definition of the environmental aspects of the study sites, heavy metal, PAH and PCB concentrations were also evaluated in the sediments. As a whole, the biological responses examined in both species from all the sampling sites showed significant differences between the two seasonal campaigns, only lysosomal membrane stability exhibited less variability. Pollutants in sediments generally showed low-intermediate contamination levels, few hotspots persisting mostly in the inner areas of the lagoon, the most influenced by the industrial zone. Transplanted mussels were more responsive than native clams and the biological responses of both species varied temporally. The range of the spatial variability was always narrow and reflected only partially the broader variability shown by the chemical content in the sediments. In this sense, biological responses seemed to be particularly influenced by the high temporal and spatial heterogeneity that characterise the Lagoon of Venice, as well as most of the transitional environments.

The role of oxygen in the photostimulation luminescence process of europium doped potassium chloride

PubMed Central

Xiao, Zhiyan; Mazur, Thomas R.; Driewer, Joseph P.; Li, H. Harold

2015-01-01

A recent suggestion that europium doped potassium chloride (KCl:Eu2+) has the potential to significantly advance the state-of-the-art in radiation therapy dosimetry has generated a renewed interest in a classic storage phosphor material. The purposes of this work are to investigate the role of oxygen in the photostimulation luminescence (PSL) process and to determine if both increased PSL yield and improved temporal stability could be realized in KCl:Eu2+ by incorporating oxygen in the material fabrication process. Regardless of synthesis atmosphere, air or pure nitrogen, PSL amplitude shows a maximum at 1.0 mol % Eu. Depending on europium concentration, dosimeters fabricated in air exhibit stronger PSL by a factor of 2 to 4 compared to those made in N2. There is no change in PSL stimulation spectrum while noticeable shifts in both photoluminescence and PSL emission spectra are observed for air versus nitrogen. Almost all charge-storage centers are spatially correlated, suggesting oxygen’s stabilization role in the PSL process. However, oxygen alone does not improve material’s temporal stability in the first few hours post irradiation at room temperature, probably because a significant portion of radiation-induced holes are stored in the Vk centers which are mobile. PMID:25897274

Synchronisation and stability in river metapopulation networks.

PubMed

Yeakel, J D; Moore, J W; Guimarães, P R; de Aguiar, M A M

2014-03-01

Spatial structure in landscapes impacts population stability. Two linked components of stability have large consequences for persistence: first, statistical stability as the lack of temporal fluctuations; second, synchronisation as an aspect of dynamic stability, which erodes metapopulation rescue effects. Here, we determine the influence of river network structure on the stability of riverine metapopulations. We introduce an approach that converts river networks to metapopulation networks, and analytically show how fluctuation magnitude is influenced by interaction structure. We show that river metapopulation complexity (in terms of branching prevalence) has nonlinear dampening effects on population fluctuations, and can also buffer against synchronisation. We conclude by showing that river transects generally increase synchronisation, while the spatial scale of interaction has nonlinear effects on synchronised dynamics. Our results indicate that this dual stability - conferred by fluctuation and synchronisation dampening - emerges from interaction structure in rivers, and this may strongly influence the persistence of river metapopulations. © 2013 John Wiley & Sons Ltd/CNRS.

Spatial and temporal dynamics of the colonization of Pinus radiata by Fusarium circinatum, of conidiophora development in the pith and of traumatic resin duct formation.

PubMed

Martín-Rodrigues, Noemí; Espinel, Santiago; Sanchez-Zabala, Joseba; Ortíz, Amaia; González-Murua, Carmen; Duñabeitia, Miren K

2013-06-01

· Fusarium circinatum causes pitch canker disease in a wide range of pine trees, including Pinus radiata, with devastating economic consequences. · To assess the spatial and temporal dynamics of growth of this pathogen in radiata pine, we examined the process of infection using both real-time PCR to quantify fungal biomass inside the plant host, and confocal microscopy using a green fluorescent protein (GFP)-tagged strain of F. circinatum. · Pathogen growth exhibited three distinct phases: an initial exponential increase in fungal biomass, concomitant with pathogen colonization of the cortex and phloem; a slowdown in fungal growth coincident with sporulating hyphae deep within the host; and stabilization of the fungal biomass when the first wilting symptoms appeared. The number of resin ducts in the xylem was found to increase in response to infection and the fungus grew inside both constitutive and traumatic resin ducts. · These results indicate that conidiation may contribute to the spatial or temporal dissemination of the pathogen. Moreover, the present findings raise the intriguing possibility that the generation of traumatic resin ducts may be of more benefit to the fungus than to the plant. © 2013 The Authors New Phytologist © 2013 New Phytologist Trust.

Selfishness, fraternity, and other-regarding preference in spatial evolutionary games.

PubMed

Szabó, György; Szolnoki, Attila

2012-04-21

Spatial evolutionary games are studied with myopic players whose payoff interest, as a personal character, is tuned from selfishness to other-regarding preference via fraternity. The players are located on a square lattice and collect income from symmetric two-person two-strategy (called cooperation and defection) games with their nearest neighbors. During the elementary steps of evolution a randomly chosen player modifies her strategy in order to maximize stochastically her utility function composed from her own and the co-players' income with weight factors 1-Q and Q. These models are studied within a wide range of payoff parameters using Monte Carlo simulations for noisy strategy updates and by spatial stability analysis in the low noise limit. For fraternal players (Q=1/2) the system evolves into ordered arrangements of strategies in the low noise limit in a way providing optimum payoff for the whole society. Dominance of defectors, representing the "tragedy of the commons", is found within the regions of prisoner's dilemma and stag hunt game for selfish players (Q=0). Due to the symmetry in the effective utility function the system exhibits similar behavior even for Q=1 that can be interpreted as the "lovers' dilemma". Copyright © 2011 Elsevier Ltd. All rights reserved.

Spatial patterns and broad-scale weather cues of beech mast seeding in Europe.

PubMed

Vacchiano, Giorgio; Hacket-Pain, Andrew; Turco, Marco; Motta, Renzo; Maringer, Janet; Conedera, Marco; Drobyshev, Igor; Ascoli, Davide

2017-07-01

Mast seeding is a crucial population process in many tree species, but its spatio-temporal patterns and drivers at the continental scale remain unknown . Using a large dataset (8000 masting observations across Europe for years 1950-2014) we analysed the spatial pattern of masting across the entire geographical range of European beech, how it is influenced by precipitation, temperature and drought, and the temporal and spatial stability of masting-weather correlations. Beech masting exhibited a general distance-dependent synchronicity and a pattern structured in three broad geographical groups consistent with continental climate regimes. Spearman's correlations and logistic regression revealed a general pattern of beech masting correlating negatively with temperature in the summer 2 yr before masting, and positively with summer temperature 1 yr before masting (i.e. 2T model). The temperature difference between the two previous summers (DeltaT model) was also a good predictor. Moving correlation analysis applied to the longest eight chronologies (74-114 yr) revealed stable correlations between temperature and masting, confirming consistency in weather cues across space and time. These results confirm widespread dependency of masting on temperature and lend robustness to the attempts to reconstruct and predict mast years using temperature data. © 2017 The Authors. New Phytologist © 2017 New Phytologist Trust.

Comparison of the colloidal stability, bioaccessibility and antioxidant activity of corn protein hydrolysate and sodium caseinate stabilized curcumin nanoparticles.

PubMed

Wang, Yong-Hui; Yuan, Yang; Yang, Xiao-Quan; Wang, Jin-Mei; Guo, Jian; Lin, Yuan

2016-07-01

The aims of this work were to construct corn protein hydrolysate (CPH)-based curcumin nanoparticles (Cur NPs) and to compare the colloidal stability, bioaccessibility and antioxidant activity of the Cur NPs stabilized CPH and sodium caseinate (NaCas) respectively. The results indicated that Cur solubility could be considerably improved after the Cur NPs fabrication. The spectroscopy results demonstrated that the solubilization of Cur should be attributed to its complexation with CPH or NaCas. The Cur NPs exhibited good colloidal stability after 1 week's storage but showed smaller (40 nm) size in CPH than in NaCas (100 nm). After lyophilization, the Cur NPs powders showed good rehydration properties and chemical stability, and compared with NaCas, the size of Cur NPs stabilized by CPH was still smaller. Additionally, the Cur NPs exhibited higher chemical stability against the temperature compared with free Cur, and the CPH could protect Cur from degradation more efficiently. Comparing with NaCas, the Cur NPs stabilized by CPH exhibited better bioaccessibility and antioxidant activity. This study demonstrated that CPH may be better than NaCas in Cur NPs fabrication and it opens up the possibility of using hydrophobic protein hydrolysate to construct the NPs delivery system.

Creating Hierarchical Pores by Controlled Linker Thermolysis in Multivariate Metal-Organic Frameworks.

PubMed

Feng, Liang; Yuan, Shuai; Zhang, Liang-Liang; Tan, Kui; Li, Jia-Luo; Kirchon, Angelo; Liu, Ling-Mei; Zhang, Peng; Han, Yu; Chabal, Yves J; Zhou, Hong-Cai

2018-02-14

Sufficient pore size, appropriate stability, and hierarchical porosity are three prerequisites for open frameworks designed for drug delivery, enzyme immobilization, and catalysis involving large molecules. Herein, we report a powerful and general strategy, linker thermolysis, to construct ultrastable hierarchically porous metal-organic frameworks (HP-MOFs) with tunable pore size distribution. Linker instability, usually an undesirable trait of MOFs, was exploited to create mesopores by generating crystal defects throughout a microporous MOF crystal via thermolysis. The crystallinity and stability of HP-MOFs remain after thermolabile linkers are selectively removed from multivariate metal-organic frameworks (MTV-MOFs) through a decarboxylation process. A domain-based linker spatial distribution was found to be critical for creating hierarchical pores inside MTV-MOFs. Furthermore, linker thermolysis promotes the formation of ultrasmall metal oxide nanoparticles immobilized in an open framework that exhibits high catalytic activity for Lewis acid-catalyzed reactions. Most importantly, this work provides fresh insights into the connection between linker apportionment and vacancy distribution, which may shed light on probing the disordered linker apportionment in multivariate systems, a long-standing challenge in the study of MTV-MOFs.

Interfacial effects in ZnO nanotubes/needle-structured graphitic diamond nanohybrid for detecting dissolved acetone at room temperature

NASA Astrophysics Data System (ADS)

Kathiravan, Deepa; Huang, Bohr-Ran; Saravanan, Adhimoorthy; Yeh, Chien-Jui; Leou, Keh-Chyang; Lin, I.-Nan

2017-12-01

A high-performance ZnO nanotubes (ZNTs)/needle-structured graphitic diamond (NGD) nanohybrid material was prepared and observed the electrochemical sensing properties of liquid acetone in water. Initially, we synthesized NGD film using bias-enhanced growth (BEG) process. Afterwards, a well-etched ZNTs were spatially grown on the NGD film using simple hydrothermal method, and utilized as sensing material for assemble an electrochemical sensor (via EGFET configuration) operating at room temperature. The systematic investigations depict the ultra-high sensing properties attained from ZNTs grown on NGD film. The NGD film mostly have needle or wire shaped diamond grains, which contributes extremely high electrical conductivity. Furthermore, needle shaped diamond grains cover with multi-layer graphitic material generates conduction channels for ZNTs and leads to enhance the oxygen residuals and species. The material stability and conductivity of NGD as well the defects exist with oxygen vacancies in ZNTs offers superior sensing properties. Thus, the interesting combination of these wide band gap semiconductor materials exhibit high sensor response (89 mV/mL), high stability and long-term reliability (tested after 60 days).

Robust indirect band gap and anisotropy of optical absorption in B-doped phosphorene.

PubMed

Wu, Zhi-Feng; Gao, Peng-Fei; Guo, Lei; Kang, Jun; Fang, Dang-Qi; Zhang, Yang; Xia, Ming-Gang; Zhang, Sheng-Li; Wen, Yu-Hua

2017-12-06

A traditional doping technique plays an important role in the band structure engineering of two-dimensional nanostructures. Since electron interaction is changed by doping, the optical and electrochemical properties could also be significantly tuned. In this study, density functional theory calculations have been employed to explore the structural stability, and electronic and optical properties of B-doped phosphorene. The results show that all B-doped phosphorenes are stable with a relatively low binding energy. Of particular interest is that these B-doped systems exhibit an indirect band gap, which is distinct from the direct one of pure phosphorene. Despite the different concentrations and configurations of B dopants, such indirect band gaps are robust. The screened hybrid density functional HSE06 predicts that the band gap of B-doped phosphorene is slightly smaller than that of pure phosphorene. Spatial charge distributions at the valence band maximum (VBM) and the conduction band minimum (CBM) are analyzed to understand the features of an indirect band gap. By comparison with pure phosphorene, B-doped phosphorenes exhibit strong anisotropy and intensity of optical absorption. Moreover, B dopants could enhance the stability of Li adsorption on phosphorene with less sacrifice of the Li diffusion rate. Our results suggest that B-doping is an effective way of tuning the band gap, enhancing the intensity of optical absorption and improving the performances of Li adsorption, which could promote potential applications in novel optical devices and lithium-ion batteries.

Encouraging Spatial Talk: Using Children's Museums to Bolster Spatial Reasoning

ERIC Educational Resources Information Center

Polinsky, Naomi; Perez, Jasmin; Grehl, Mora; McCrink, Koleen

2017-01-01

Longitudinal spatial language intervention studies have shown that greater exposure to spatial language improves children's performance on spatial tasks. Can short naturalistic, spatial language interactions also evoke improved spatial performance? In this study, parents were asked to interact with their child at a block wall exhibit in a…

In situ probing of doping- and stress-mediated phase transitions in a single-crystalline VO2 nanobeam by spatially resolved Raman spectroscopy

NASA Astrophysics Data System (ADS)

Chang, Sung-Jin; Park, Jong Bae; Lee, Gaehang; Kim, Hae Jin; Lee, Jin-Bae; Bae, Tae-Sung; Han, Young-Kyu; Park, Tae Jung; Huh, Yun Suk; Hong, Woong-Ki

2014-06-01

We demonstrate an experimental in situ observation of the temperature-dependent evolution of doping- and stress-mediated structural phase transitions in an individual single-crystalline VO2 nanobeam on a Au-coated substrate under exposure to hydrogen gas using spatially resolved Raman spectroscopy. The nucleation temperature of the rutile R structural phase in the VO2 nanobeam upon heating under hydrogen gas was lower than that under air. The spatial structural phase evolution behavior along the length of the VO2 nanobeam under hydrogen gas upon heating was much more inhomogeneous than that along the length of the same nanobeam under air. The triclinic T phase of the VO2 nanobeam upon heating under hydrogen gas transformed to the R phase and this R phase was stabilized even at room temperature in air after sample cooling. In particular, after the VO2 nanobeam with the R phase was annealed at approximately 250 °C in air, it exhibited the monoclinic M1 phase (not the T phase) at room temperature during heating and cooling cycles. These results were attributed to the interplay between hydrogen doping and stress associated with nanobeam-substrate interactions. Our study has important implications for engineering metal-insulator transition properties and developing functional devices based on VO2 nanostructures through doping and stress.We demonstrate an experimental in situ observation of the temperature-dependent evolution of doping- and stress-mediated structural phase transitions in an individual single-crystalline VO2 nanobeam on a Au-coated substrate under exposure to hydrogen gas using spatially resolved Raman spectroscopy. The nucleation temperature of the rutile R structural phase in the VO2 nanobeam upon heating under hydrogen gas was lower than that under air. The spatial structural phase evolution behavior along the length of the VO2 nanobeam under hydrogen gas upon heating was much more inhomogeneous than that along the length of the same nanobeam under air. The triclinic T phase of the VO2 nanobeam upon heating under hydrogen gas transformed to the R phase and this R phase was stabilized even at room temperature in air after sample cooling. In particular, after the VO2 nanobeam with the R phase was annealed at approximately 250 °C in air, it exhibited the monoclinic M1 phase (not the T phase) at room temperature during heating and cooling cycles. These results were attributed to the interplay between hydrogen doping and stress associated with nanobeam-substrate interactions. Our study has important implications for engineering metal-insulator transition properties and developing functional devices based on VO2 nanostructures through doping and stress. Electronic supplementary information (ESI) available: Illustration, photograph, Raman data, and EDX spectra. See DOI: 10.1039/c4nr01118j

Non Lyapunov stability of the constant spatially developing 1-D gas flow in presence of solutions having strictly positive exponential growth rate

NASA Astrophysics Data System (ADS)

Balint, Stefan; Balint, Agneta M.

2017-01-01

Different types of stabilities (global, local) and instabilities (global absolute, local convective) of the constant spatially developing 1-D gas flow are analyzed in the phase space of continuously differentiable functions, endowed with the usual algebraic operations and the topology generated by the uniform convergence on the real axis. For this purpose the Euler equations linearized at the constant flow are used. The Lyapunov stability analysis was presented in [1] and this paper is a continuation of [1].

Multiscale responses of soil stability and invasive plants to removal of non-native grazers from an arid conservation reserve

USGS Publications Warehouse

Beever, E.A.; Huso, M.; Pyke, D.A.

2006-01-01

Disturbances and ecosystem recovery from disturbance both involve numerous processes that operate on multiple spatial and temporal scales. Few studies have investigated how gradients of disturbance intensity and ecosystem responses are distributed across multiple spatial resolutions and also how this relationship changes through time during recovery. We investigated how cover of non-native species and soil-aggregate stability (a measure of vulnerability to erosion by water) in surface and subsurface soils varied spatially during grazing by burros and cattle and whether patterns in these variables changed after grazer removal from Mojave National Preserve, California, USA. We compared distance from water and number of ungulate defecations - metrics of longer-term and recent grazing intensity, respectively, - as predictors of our response variables. We used information-theoretic analyses to compare hierarchical linear models that accounted for important covariates and allowed for interannual variation in the disturbance-response relationship at local and landscape scales. Soil stability was greater under perennial vegetation than in bare interspaces, and surface soil stability decreased with increasing numbers of ungulate defecations. Stability of surface samples was more affected by time since removal of grazers than was stability of subsurface samples, and subsurface soil stability in bare spaces was not related to grazing intensity, time since removal, or any of our other predictors. In the high rainfall year (2003) after cattle had been removed for 1-2 years, cover of all non-native plants averaged nine times higher than in the low-rainfall year (2002). Given the heterogeneity in distribution of large-herbivore impacts that we observed at several resolutions, hierarchical analyses provided a more complete understanding of the spatial and temporal complexities of disturbance and recovery processes in arid ecosystems. ?? 2006 Blackwell Publishing Ltd.

Multi-scale responses of soil stability and invasive plants to removal of non-native grazers from an arid conservation reserve

USGS Publications Warehouse

Beever, Erik A.; Huso, Manuela M. P.; Pyke, David A.

2006-01-01

Disturbances and ecosystem recovery from disturbance both involve numerous processes that operate on multiple spatial and temporal scales. Few studies have investigated how gradients of disturbance intensity and ecosystem responses are distributed across multiple spatial resolutions and also how this relationship changes through time during recovery. We investigated how cover of non-native species and soil-aggregate stability (a measure of vulnerability to erosion by water) in surface and subsurface soils varied spatially during grazing by burros and cattle and whether patterns in these variables changed after grazer removal from Mojave National Preserve, California, USA. We compared distance from water and number of ungulate defecations — metrics of longer-term and recent grazing intensity, respectively, — as predictors of our response variables. We used information-theoretic analyses to compare hierarchical linear models that accounted for important covariates and allowed for interannual variation in the disturbance–response relationship at local and landscape scales. Soil stability was greater under perennial vegetation than in bare interspaces, and surface soil stability decreased with increasing numbers of ungulate defecations. Stability of surface samples was more affected by time since removal of grazers than was stability of subsurface samples, and subsurface soil stability in bare spaces was not related to grazing intensity, time since removal, or any of our other predictors. In the high rainfall year (2003) after cattle had been removed for 1–2 years, cover of all non-native plants averaged nine times higher than in the low-rainfall year (2002). Given the heterogeneity in distribution of large-herbivore impacts that we observed at several resolutions, hierarchical analyses provided a more complete understanding of the spatial and temporal complexities of disturbance and recovery processes in arid ecosystems.

Sulphur Atoms from Methionines Interacting with Aromatic Residues Are Less Prone to Oxidation

PubMed Central

Aledo, Juan C.; Cantón, Francisco R.; Veredas, Francisco J.

2015-01-01

Methionine residues exhibit different degrees of susceptibility to oxidation. Although solvent accessibility is a relevant factor, oxidation at particular sites cannot be unequivocally explained by accessibility alone. To explore other possible structural determinants, we assembled different sets of oxidation-sensitive and oxidation-resistant methionines contained in human proteins. Comparisons of the proteins containing oxidized methionines with all proteins in the human proteome led to the conclusion that the former exhibit a significantly higher mean value of methionine content than the latter. Within a given protein, an examination of the sequence surrounding the non-oxidized methionine revealed a preference for neighbouring tyrosine and tryptophan residues, but not for phenylalanine residues. However, because the interaction between sulphur atoms and aromatic residues has been reported to be important for the stabilization of protein structure, we carried out an analysis of the spatial interatomic distances between methionines and aromatic residues, including phenylalanine. The results of these analyses uncovered a new determinant for methionine oxidation: the S-aromatic motif, which decreases the reactivity of the involved sulphur towards oxidants. PMID:26597773

The Hall-induced stability of gravitating fluids

NASA Astrophysics Data System (ADS)

Karmakar, P. K.; Goutam, H. P.

2018-05-01

We analyze the stability behavior of low-density partially ionized self-gravitating magnetized unbounded dusty plasma fluid in the presence of the Hall diffusion effects (HDEs) in the non-ideal magnetohydrodynamic (MHD) equilibrium framework. The effects of inhomogeneous self-gravity are methodically included in the basic model tapestry. Application of the Fourier plane-wave perturbative treatment decouples the structuration representative parameters into a linear generalized dispersion relation (sextic) in a judicious mean-fluid approximation. The dispersion analysis shows that the normal mode, termed as the gravito-magneto-acoustic (GMA) mode, is drastically modified due to the HDEs. This mode is highly dispersive, and driven unstable by the Hall current resulting from the symmetry-breaking of electrons and ions relative to the magnetic field. The mode feature, which is derived from a modified induction with the positive Hall, is against the ideal MHD. It is further demonstrated that the HDEs play stabilizing roles by supporting the cloud against gravitational collapse. Provided that the HDEs are concurrently switched off, the collapse occurs on the global spatial scale due to enhanced inward accretion of the gravitating dust constituents. It is seen explicitly that the enhanced dust-charge leads to stabilizing effects. Besides, the Hall-induced fluctuations, as propagatory wave modes, exhibit both normal and anomalous dispersions. The reliability checkup of the entailed results as diverse corollaries and special cases are illustratively discussed in the panoptic light of the earlier paradigmatic predictions available in the literature.

Reference memory, anxiety and estrous cyclicity in C57BL/6NIA mice are affected by age and sex.

PubMed

Frick, K M; Burlingame, L A; Arters, J A; Berger-Sweeney, J

2000-01-01

Age-related changes in learning and memory are common in rodents. However, direct comparisons of the effects of aging on learning and memory in both males and females are lacking. The present study examined whether memory deteriorates with increasing age in C57BL/6NIA mice, and whether age-related changes in learning and memory are similar in both sexes. Male and female mice (five, 17 and 25 months of age) were tested in a battery of behavioral tasks including the Morris water maze (spatial and non-spatial reference memory), simple odor discrimination (olfactory reference memory), plus maze (anxiety/exploration), locomotor activity, and basic reflexes. Five-month-old mice learned the water maze and odor discrimination tasks rapidly. Relative to five-month-old mice, 25-month-old mice exhibited impaired spatial and olfactory reference memory, but intact non-spatial reference memory. The spatial reference memory of 17-month-old mice was also impaired, but less so than 25-month mice. Seventeen-month-old mice exhibited intact non-spatial (visual and olfactory) reference memory. Five and 25-month-old mice had similar levels of plus maze exploration and locomotor activity, whereas 17-month-old mice were more active than both groups and were slightly less exploratory than five-month-old mice. Although sex differences were not observed in the five- and 25-month groups, 17-month-old females exhibited more impaired spatial reference memory and increased anxiety relative to 17-month-old males. Estrous cycling in females deteriorated significantly with increased age; all 25-month-old females had ceased cycling and 80% of 17-month-old females displayed either irregular or absent estrous cycling. This study is the first to directly compare age-related mnemonic decline in male and female mice. The results suggest that: (i) aged mice exhibit significant deficits in spatial and olfactory reference memory relative to young mice, whereas middle-aged mice exhibit only a moderate spatial memory deficit and; (ii) spatial reference memory decline begins at an earlier age in females than in males, a finding that may be related to the cessation of estrous cycling.

Spatial and temporal relationships among watershed mining, water quality, and freshwater mussel status in an eastern USA river.

PubMed

Zipper, Carl E; Donovan, Patricia F; Jones, Jess W; Li, Jing; Price, Jennifer E; Stewart, Roger E

2016-01-15

The Powell River of southwestern Virginia and northeastern Tennessee, USA, drains a watershed with extensive coal surface mining, and it hosts exceptional biological richness, including at-risk species of freshwater mussels, downstream of mining-disturbed watershed areas. We investigated spatial and temporal patterns of watershed mining disturbance; their relationship to water quality change in the section of the river that connects mining areas to mussel habitat; and relationships of mining-related water constituents to measures of recent and past mussel status. Freshwater mussels in the Powell River have experienced significant declines over the past 3.5 decades. Over that same period, surface coal mining has influenced the watershed. Water-monitoring data collected by state and federal agencies demonstrate that dissolved solids and associated constituents that are commonly influenced by Appalachian mining (specific conductance, pH, hardness and sulfates) have experienced increasing temporal trends from the 1960s through ~2008; but, of those constituents, only dissolved solids concentrations are available widely within the Powell River since ~2008. Dissolved solids concentrations have stabilized in recent years. Dissolved solids, specific conductance, pH, and sulfates also exhibited spatial patterns that are consistent with dilution of mining influence with increasing distance from mined areas. Freshwater mussel status indicators are correlated negatively with dissolved solids concentrations, spatially and temporally, but the direct causal mechanisms responsible for mussel declines remain unknown. Copyright © 2015 Elsevier B.V. All rights reserved.

Stability and complexity in model meta-ecosystems

PubMed Central

Gravel, Dominique; Massol, François; Leibold, Mathew A.

2016-01-01

The diversity of life and its organization in networks of interacting species has been a long-standing theoretical puzzle for ecologists. Ever since May's provocative paper challenging whether ‘large complex systems [are] stable' various hypotheses have been proposed to explain when stability should be the rule, not the exception. Spatial dynamics may be stabilizing and thus explain high community diversity, yet existing theory on spatial stabilization is limited, preventing comparisons of the role of dispersal relative to species interactions. Here we incorporate dispersal of organisms and material into stability–complexity theory. We find that stability criteria from classic theory are relaxed in direct proportion to the number of ecologically distinct patches in the meta-ecosystem. Further, we find the stabilizing effect of dispersal is maximal at intermediate intensity. Our results highlight how biodiversity can be vulnerable to factors, such as landscape fragmentation and habitat loss, that isolate local communities. PMID:27555100

Walk, Look, Remember: The Influence of the Gallery's Spatial Layout on Human Memory for an Art Exhibition.

PubMed

Krukar, Jakub

2014-09-01

The spatial organisation of museums and its influence on the visitor experience has been the subject of numerous studies. Previous research, despite reporting some actual behavioural correlates, rarely had the possibility to investigate the cognitive processes of the art viewers. In the museum context, where spatial layout is one of the most powerful curatorial tools available, attention and memory can be measured as a means of establishing whether or not the gallery fulfils its function as a space for contemplating art. In this exploratory experiment, 32 participants split into two groups explored an experimental, non-public exhibition and completed two unanticipated memory tests afterwards. The results show that some spatial characteristics of an exhibition can inhibit the recall of pictures and shift the focus to perceptual salience of the artworks.

Walk, Look, Remember: The Influence of the Gallery’s Spatial Layout on Human Memory for an Art Exhibition

PubMed Central

Krukar, Jakub

2014-01-01

The spatial organisation of museums and its influence on the visitor experience has been the subject of numerous studies. Previous research, despite reporting some actual behavioural correlates, rarely had the possibility to investigate the cognitive processes of the art viewers. In the museum context, where spatial layout is one of the most powerful curatorial tools available, attention and memory can be measured as a means of establishing whether or not the gallery fulfils its function as a space for contemplating art. In this exploratory experiment, 32 participants split into two groups explored an experimental, non-public exhibition and completed two unanticipated memory tests afterwards. The results show that some spatial characteristics of an exhibition can inhibit the recall of pictures and shift the focus to perceptual salience of the artworks. PMID:25379276

The balance between keystone clustering and bed roughness in experimental step-pool stabilization

NASA Astrophysics Data System (ADS)

Johnson, J. P.

2016-12-01

Predicting how mountain channels will respond to environmental perturbations such as floods requires an improved quantitative understanding of morphodynamic feedbacks among bed topography, surface grain size and sediment sorting. In boulder-rich gravel streams, transport and sorting often lead to the development of step pool morphologies, which are expressed both in bed topography and coarse grain clustering. Bed stability is difficult to measure, and is sometimes inferred from the presence of step pools. I use scaled flume experiments to explore feedbacks among surface grain sizes, coarse grain clustering, bed roughness and hydraulic roughness during progressive bed stabilization and over a range of sediment transport rates. While grain clusters are sometimes identified by subjective interpretation, I quantify the degree of coarse surface grain clustering using spatial statistics, including a novel normalization of Ripley's K function. This approach is objective and provides information on the strength of clustering over a range of length scales. Flume experiments start with an initial bed surface with a broad grain size distribution and spatially random positions. Flow causes the bed surface to progressively stabilize in response to erosion, surface coarsening, roughening and grain reorganization. At 95% confidence, many but not all beds stabilized with coarse grains becoming more clustered than complete spatial randomness (CSR). I observe a tradeoff between topographic roughness and clustering. Beds that stabilized with higher degrees of coarse-grain clustering were topographically smoother, and vice-versa. Initial conditions influenced the degree of clustering at stability: Beds that happened to have fewer initial coarse grains had more coarse grain reorganization during stabilization, leading to more clustering. Finally, regressions demonstrate that clustering statistics actually predict hydraulic roughness significantly better than does D84 (the size at which 84% of grains are smaller). In the experimental data, the spatial organization of surface grains is a stronger control on flow characteristics than the size of surface grains.

Grid scale drives the scale and long-term stability of place maps

PubMed Central

Mallory, Caitlin S; Hardcastle, Kiah; Bant, Jason S; Giocomo, Lisa M

2018-01-01

Medial entorhinal cortex (MEC) grid cells fire at regular spatial intervals and project to the hippocampus, where place cells are active in spatially restricted locations. One feature of the grid population is the increase in grid spatial scale along the dorsal-ventral MEC axis. However, the difficulty in perturbing grid scale without impacting the properties of other functionally-defined MEC cell types has obscured how grid scale influences hippocampal coding and spatial memory. Here, we use a targeted viral approach to knock out HCN1 channels selectively in MEC, causing grid scale to expand while leaving other MEC spatial and velocity signals intact. Grid scale expansion resulted in place scale expansion in fields located far from environmental boundaries, reduced long-term place field stability and impaired spatial learning. These observations, combined with simulations of a grid-to-place cell model and position decoding of place cells, illuminate how grid scale impacts place coding and spatial memory. PMID:29335607

Stability of spatially developing boundary layers

NASA Astrophysics Data System (ADS)

Govindarajan, Rama

1993-07-01

A new formulation of the stability of boundary-layer flows in pressure gradients is presented, taking into account the spatial development of the flow. The formulation assumes that disturbance wavelength and eigenfunction vary downstream no more rapidly than the boundary-layer thickness, and includes all terms of O(1) and O(R(exp -1)) in the boundary-layer Reynolds number R. Although containing the Orr-Sommerfeld operator, the present approach does not yield the Orr-Sommerfeld equation in any rational limit. In Blasius flow, the present stability equation is consistent with that of Bertolotti et al. (1992) to terms of O(R(exp -1)). For the Falkner-Skan similarity solutions neutral boundaries are computed without the necessity of having to march in space. Results show that the effects of spatial growth are striking in flows subjected to adverse pressure gradients.

Assessing the accuracy and stability of variable selection methods for random forest modeling in ecology.

PubMed

Fox, Eric W; Hill, Ryan A; Leibowitz, Scott G; Olsen, Anthony R; Thornbrugh, Darren J; Weber, Marc H

2017-07-01

Random forest (RF) modeling has emerged as an important statistical learning method in ecology due to its exceptional predictive performance. However, for large and complex ecological data sets, there is limited guidance on variable selection methods for RF modeling. Typically, either a preselected set of predictor variables are used or stepwise procedures are employed which iteratively remove variables according to their importance measures. This paper investigates the application of variable selection methods to RF models for predicting probable biological stream condition. Our motivating data set consists of the good/poor condition of n = 1365 stream survey sites from the 2008/2009 National Rivers and Stream Assessment, and a large set (p = 212) of landscape features from the StreamCat data set as potential predictors. We compare two types of RF models: a full variable set model with all 212 predictors and a reduced variable set model selected using a backward elimination approach. We assess model accuracy using RF's internal out-of-bag estimate, and a cross-validation procedure with validation folds external to the variable selection process. We also assess the stability of the spatial predictions generated by the RF models to changes in the number of predictors and argue that model selection needs to consider both accuracy and stability. The results suggest that RF modeling is robust to the inclusion of many variables of moderate to low importance. We found no substantial improvement in cross-validated accuracy as a result of variable reduction. Moreover, the backward elimination procedure tended to select too few variables and exhibited numerous issues such as upwardly biased out-of-bag accuracy estimates and instabilities in the spatial predictions. We use simulations to further support and generalize results from the analysis of real data. A main purpose of this work is to elucidate issues of model selection bias and instability to ecologists interested in using RF to develop predictive models with large environmental data sets.

Your brain on speed: cognitive performance of a spatial working memory task is not affected by walking speed

PubMed Central

Kline, Julia E.; Poggensee, Katherine; Ferris, Daniel P.

2014-01-01

When humans walk in everyday life, they typically perform a range of cognitive tasks while they are on the move. Past studies examining performance changes in dual cognitive-motor tasks during walking have produced a variety of results. These discrepancies may be related to the type of cognitive task chosen, differences in the walking speeds studied, or lack of controlling for walking speed. The goal of this study was to determine how young, healthy subjects performed a spatial working memory task over a range of walking speeds. We used high-density electroencephalography to determine if electrocortical activity mirrored changes in cognitive performance across speeds. Subjects stood (0.0 m/s) and walked (0.4, 0.8, 1.2, and 1.6 m/s) with and without performing a Brooks spatial working memory task. We hypothesized that performance of the spatial working memory task and the associated electrocortical activity would decrease significantly with walking speed. Across speeds, the spatial working memory task caused subjects to step more widely compared with walking without the task. This is typically a sign that humans are adapting their gait dynamics to increase gait stability. Several cortical areas exhibited power fluctuations time-locked to memory encoding during the cognitive task. In the somatosensory association cortex, alpha power increased prior to stimulus presentation and decreased during memory encoding. There were small significant reductions in theta power in the right superior parietal lobule and the posterior cingulate cortex around memory encoding. However, the subjects did not show a significant change in cognitive task performance or electrocortical activity with walking speed. These findings indicate that in young, healthy subjects walking speed does not affect performance of a spatial working memory task. These subjects can devote adequate cortical resources to spatial cognition when needed, regardless of walking speed. PMID:24847239

Endogenous spatial attention: evidence for intact functioning in adults with autism

PubMed Central

Grubb, Michael A.; Behrmann, Marlene; Egan, Ryan; Minshew, Nancy J.; Carrasco, Marisa; Heeger, David J.

2012-01-01

Lay Abstract Attention allows us to selectively process the vast amount of information with which we are confronted. Focusing on a certain location of the visual scene (visual spatial attention) enables the prioritization of some aspects of information while ignoring others. Rapid manipulation of the attention field (i.e., the location and spread of visual spatial attention) is a critical aspect of human cognition, and previous research on spatial attention in individuals with autism spectrum disorders (ASD) has produced inconsistent results. In a series of three experiments, we evaluated claims in the literature that individuals with ASD exhibit a deficit in voluntarily controlling the deployment and size of the spatial attention field. We measured how well participants perform a visual discrimination task (accuracy) and how quickly they do so (reaction time), with and without spatial uncertainty (i.e., the lack of predictability concerning the spatial position of the upcoming stimulus). We found that high–functioning adults with autism exhibited slower reactions times overall with spatial uncertainty, but the effects of attention on performance accuracies and reaction times were indistinguishable between individuals with autism and typically developing individuals, in all three experiments. These results provide evidence of intact endogenous spatial attention function in high–functioning adults with ASD, suggesting that atypical endogenous spatial attention cannot be a latent characteristic of autism in general. Scientific Abstract Rapid manipulation of the attention field (i.e., the location and spread of visual spatial attention) is a critical aspect of human cognition, and previous research on spatial attention in individuals with autism spectrum disorders (ASD) has produced inconsistent results. In a series of three psychophysical experiments, we evaluated claims in the literature that individuals with ASD exhibit a deficit in voluntarily controlling the deployment and size of the spatial attention field. We measured the spatial distribution of performance accuracies and reaction times to quantify the sizes and locations of the attention field, with and without spatial uncertainty (i.e., the lack of predictability concerning the spatial position of the upcoming stimulus). We found that high–functioning adults with autism exhibited slower reactions times overall with spatial uncertainty, but the effects of attention on performance accuracies and reaction times were indistinguishable between individuals with autism and typically developing individuals, in all three experiments. These results provide evidence of intact endogenous spatial attention function in high–functioning adults with ASD, suggesting that atypical endogenous attention cannot be a latent characteristic of autism in general. PMID:23427075

Finite time step and spatial grid effects in δf simulation of warm plasmas

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sturdevant, Benjamin J., E-mail: benjamin.j.sturdevant@gmail.com; Department of Applied Mathematics, University of Colorado at Boulder, Boulder, CO 80309; Parker, Scott E.

2016-01-15

This paper introduces a technique for analyzing time integration methods used with the particle weight equations in δf method particle-in-cell (PIC) schemes. The analysis applies to the simulation of warm, uniform, periodic or infinite plasmas in the linear regime and considers the collective behavior similar to the analysis performed by Langdon for full-f PIC schemes [1,2]. We perform both a time integration analysis and spatial grid analysis for a kinetic ion, adiabatic electron model of ion acoustic waves. An implicit time integration scheme is studied in detail for δf simulations using our weight equation analysis and for full-f simulations usingmore » the method of Langdon. It is found that the δf method exhibits a CFL-like stability condition for low temperature ions, which is independent of the parameter characterizing the implicitness of the scheme. The accuracy of the real frequency and damping rate due to the discrete time and spatial schemes is also derived using a perturbative method. The theoretical analysis of numerical error presented here may be useful for the verification of simulations and for providing intuition for the design of new implicit time integration schemes for the δf method, as well as understanding differences between δf and full-f approaches to plasma simulation.« less

Spatio-temporal patterns of key exploited marine species in the Northwestern Mediterranean Sea.

PubMed

Morfin, Marie; Fromentin, Jean-Marc; Jadaud, Angélique; Bez, Nicolas

2012-01-01

This study analyzes the temporal variability/stability of the spatial distributions of key exploited species in the Gulf of Lions (Northwestern Mediterranean Sea). To do so, we analyzed data from the MEDITS bottom-trawl scientific surveys from 1994 to 2010 at 66 fixed stations and selected 12 key exploited species. We proposed a geostatistical approach to handle zero-inflated and non-stationary distributions and to test for the temporal stability of the spatial structures. Empirical Orthogonal Functions and other descriptors were then applied to investigate the temporal persistence and the characteristics of the spatial patterns. The spatial structure of the distribution (i.e. the pattern of spatial autocorrelation) of the 12 key species studied remained highly stable over the time period sampled. The spatial distributions of all species obtained through kriging also appeared to be stable over time, while each species displayed a specific spatial distribution. Furthermore, adults were generally more densely concentrated than juveniles and occupied areas included in the distribution of juveniles. Despite the strong persistence of spatial distributions, we also observed that the area occupied by each species was correlated to its abundance: the more abundant the species, the larger the occupation area. Such a result tends to support MacCall's basin theory, according to which density-dependence responses would drive the expansion of those 12 key species in the Gulf of Lions. Further analyses showed that these species never saturated their habitats, suggesting that they are below their carrying capacity; an assumption in agreement with the overexploitation of several of these species. Finally, the stability of their spatial distributions over time and their potential ability to diffuse outside their main habitats give support to Marine Protected Areas as a potential pertinent management tool.

Evaluation of Simulated Clinical Breast Exam Motion Patterns Using Marker-Less Video Tracking

PubMed Central

Azari, David P.; Pugh, Carla M.; Laufer, Shlomi; Kwan, Calvin; Chen, Chia-Hsiung; Yen, Thomas Y.; Hu, Yu Hen; Radwin, Robert G.

2016-01-01

Objective This study investigates using marker-less video tracking to evaluate hands-on clinical skills during simulated clinical breast examinations (CBEs). Background There are currently no standardized and widely accepted CBE screening techniques. Methods Experienced physicians attending a national conference conducted simulated CBEs presenting different pathologies with distinct tumorous lesions. Single hand exam motion was recorded and analyzed using marker-less video tracking. Four kinematic measures were developed to describe temporal (time pressing and time searching) and spatial (area covered and distance explored) patterns. Results Mean differences between time pressing, area covered, and distance explored varied across the simulated lesions. Exams were objectively categorized as either sporadic, localized, thorough, or efficient for both temporal and spatial categories based on spatiotemporal characteristics. The majority of trials were temporally or spatially thorough (78% and 91%), exhibiting proportionally greater time pressing and time searching (temporally thorough) and greater area probed with greater distance explored (spatially thorough). More efficient exams exhibited proportionally more time pressing with less time searching (temporally efficient) and greater area probed with less distance explored (spatially efficient). Just two (5.9 %) of the trials exhibited both high temporal and spatial efficiency. Conclusions Marker-less video tracking was used to discriminate different examination techniques and measure when an exam changes from general searching to specific probing. The majority of participants exhibited more thorough than efficient patterns. Application Marker-less video kinematic tracking may be useful for quantifying clinical skills for training and assessment. PMID:26546381

An ALMA view of star formation efficiency suppression in early-type galaxies after gas-rich minor mergers

NASA Astrophysics Data System (ADS)

van de Voort, Freeke; Davis, Timothy A.; Matsushita, Satoki; Rowlands, Kate; Shabala, Stanislav S.; Allison, James R.; Ting, Yuan-Sen; Sansom, Anne E.; van der Werf, Paul P.

2018-05-01

Gas-rich minor mergers contribute significantly to the gas reservoir of early-type galaxies (ETGs) at low redshift, yet the star formation efficiency (SFE; the star formation rate divided by the molecular gas mass) appears to be strongly suppressed following some of these events, in contrast to the more well-known merger-driven starbursts. We present observations with the Atacama Large Millimeter/submillimeter Array (ALMA) of six ETGs, which have each recently undergone a gas-rich minor merger, as evidenced by their disturbed stellar morphologies. These galaxies were selected because they exhibit extremely low SFEs. We use the resolving power of ALMA to study the morphology and kinematics of the molecular gas. The majority of our galaxies exhibit spatial and kinematical irregularities, such as detached gas clouds, warps, and other asymmetries. These asymmetries support the interpretation that the suppression of the SFE is caused by dynamical effects stabilizing the gas against gravitational collapse. Through kinematic modelling we derive high velocity dispersions and Toomre Q stability parameters for the gas, but caution that such measurements in edge-on galaxies suffer from degeneracies. We estimate merger ages to be about 100 Myr based on the observed disturbances in the gas distribution. Furthermore, we determine that these galaxies lie, on average, two orders of magnitude below the Kennicutt-Schmidt relation for star-forming galaxies as well as below the relation for relaxed ETGs. We discuss potential dynamical processes responsible for this strong suppression of star formation surface density at fixed molecular gas surface density.

The isolation of spatial patterning modes in a mathematical model of juxtacrine cell signalling.

PubMed

O'Dea, R D; King, J R

2013-06-01

Juxtacrine signalling mechanisms are known to be crucial in tissue and organ development, leading to spatial patterns in gene expression. We investigate the patterning behaviour of a discrete model of juxtacrine cell signalling due to Owen & Sherratt (1998, Mathematical modelling of juxtacrine cell signalling. Math. Biosci., 153, 125-150) in which ligand molecules, unoccupied receptors and bound ligand-receptor complexes are modelled. Feedback between the ligand and receptor production and the level of bound receptors is incorporated. By isolating two parameters associated with the feedback strength and employing numerical simulation, linear stability and bifurcation analysis, the pattern-forming behaviour of the model is analysed under regimes corresponding to lateral inhibition and induction. Linear analysis of this model fails to capture the patterning behaviour exhibited in numerical simulations. Via bifurcation analysis, we show that since the majority of periodic patterns fold subcritically from the homogeneous steady state, a wide variety of stable patterns exists at a given parameter set, providing an explanation for this failure. The dominant pattern is isolated via numerical simulation. Additionally, by sampling patterns of non-integer wavelength on a discrete mesh, we highlight a disparity between the continuous and discrete representations of signalling mechanisms: in the continuous case, patterns of arbitrary wavelength are possible, while sampling such patterns on a discrete mesh leads to longer wavelength harmonics being selected where the wavelength is rational; in the irrational case, the resulting aperiodic patterns exhibit 'local periodicity', being constructed from distorted stable shorter wavelength patterns. This feature is consistent with experimentally observed patterns, which typically display approximate short-range periodicity with defects.

Acoustical stability of a sonoluminescing bubble

NASA Astrophysics Data System (ADS)

Holzfuss, Joachim; Rüggeberg, Matthias; Holt, R. Glynn

2002-10-01

In the parameter region for sonoluminescence of a single levitated bubble in a water-filled resonator it is observed that the bubble may have an enormous spatial stability leaving it ``pinned'' in the fluid and allowing it to emit light pulses of picosecond accuracy. We report here observations of a complex harmonic structure in the acoustic field surrounding a sonoluminescing bubble. We show that this complex sound field determines the position of the bubble and may either increase or decrease its spatial stability. The acoustic environment of the bubble is the result of the excitation of high-order normal modes of the resonator by the outgoing shock wave generated by the bubble collapse.

Stabilization of active matter by flow-vortex lattices and defect ordering

PubMed Central

Doostmohammadi, Amin; Adamer, Michael F.; Thampi, Sumesh P.; Yeomans, Julia M.

2016-01-01

Active systems, from bacterial suspensions to cellular monolayers, are continuously driven out of equilibrium by local injection of energy from their constituent elements and exhibit turbulent-like and chaotic patterns. Here we demonstrate both theoretically and through numerical simulations, that the crossover between wet active systems, whose behaviour is dominated by hydrodynamics, and dry active matter where any flow is screened, can be achieved by using friction as a control parameter. Moreover, we discover unexpected vortex ordering at this wet–dry crossover. We show that the self organization of vortices into lattices is accompanied by the spatial ordering of topological defects leading to active crystal-like structures. The emergence of vortex lattices, which leads to the positional ordering of topological defects, suggests potential applications in the design and control of active materials. PMID:26837846

Functional properties of protein isolates extracted from stabilized rice bran by microwave, dry heat, and parboiling.

PubMed

Khan, Saima Hafeez; Butt, Masood Sadiq; Sharif, Mian Kamran; Sameen, Ayesha; Mumtaz, Semee; Sultan, Muhammad Tauseef

2011-03-23

Protein isolates extracted from differently stabilized rice bran were analyzed to work out the food use potential. Bulk density remained higher for isolates obtained from heat stabilized bran, the treatments were found to have positive impact on the oil absorption properties, while the water absorption was slightly impaired owing to some possible configurational changes. Surface hydrophobicity and emulsion properties were improved with bran stabilization. Isolates exhibited better foaming properties owing to the flexible nature of protein molecules, with less intensive disulfide bonding, that were slightly affected by the stabilization treatment. Nitrogen solubility index followed a curved pattern with the least value near isoelectric point that showed an increasing trend toward basic pH, and parboiled protein isolates exhibited better gelling properties among the isolates.

Soil-Structural Stability as Affected by Clay Mineralogy, Soil Texture and Polyacrylamide Application

USDA-ARS?s Scientific Manuscript database

Soil-structural stability (expressed in terms of aggregate stability and pore size distribution) depends on (i) soil inherent properties, (ii) extrinsic condition prevailing in the soil that may vary temporally and spatially, and (iii) addition of soil amendments. Different soil management practices...

Errors on interrupter tasks presented during spatial and verbal working memory performance are linearly linked to large-scale functional network connectivity in high temporal resolution resting state fMRI.

PubMed

Magnuson, Matthew Evan; Thompson, Garth John; Schwarb, Hillary; Pan, Wen-Ju; McKinley, Andy; Schumacher, Eric H; Keilholz, Shella Dawn

2015-12-01

The brain is organized into networks composed of spatially separated anatomical regions exhibiting coherent functional activity over time. Two of these networks (the default mode network, DMN, and the task positive network, TPN) have been implicated in the performance of a number of cognitive tasks. To directly examine the stable relationship between network connectivity and behavioral performance, high temporal resolution functional magnetic resonance imaging (fMRI) data were collected during the resting state, and behavioral data were collected from 15 subjects on different days, exploring verbal working memory, spatial working memory, and fluid intelligence. Sustained attention performance was also evaluated in a task interleaved between resting state scans. Functional connectivity within and between the DMN and TPN was related to performance on these tasks. Decreased TPN resting state connectivity was found to significantly correlate with fewer errors on an interrupter task presented during a spatial working memory paradigm and decreased DMN/TPN anti-correlation was significantly correlated with fewer errors on an interrupter task presented during a verbal working memory paradigm. A trend for increased DMN resting state connectivity to correlate to measures of fluid intelligence was also observed. These results provide additional evidence of the relationship between resting state networks and behavioral performance, and show that such results can be observed with high temporal resolution fMRI. Because cognitive scores and functional connectivity were collected on nonconsecutive days, these results highlight the stability of functional connectivity/cognitive performance coupling.

Noisy transcription factor NF-κB oscillations stabilize and sensitize cytokine signaling in space

NASA Astrophysics Data System (ADS)

Gangstad, Sirin W.; Feldager, Cilie W.; Juul, Jeppe; Trusina, Ala

2013-02-01

NF-κB is a major transcription factor mediating inflammatory response. In response to a pro-inflammatory stimulus, it exhibits a characteristic response—a pulse followed by noisy oscillations in concentrations of considerably smaller amplitude. NF-κB is an important mediator of cellular communication, as it is both activated by and upregulates production of cytokines, signals used by white blood cells to find the source of inflammation. While the oscillatory dynamics of NF-κB has been extensively investigated both experimentally and theoretically, the role of the noise and the lower secondary amplitude has not been addressed. We use a cellular automaton model to address these issues in the context of spatially distributed communicating cells. We find that noisy secondary oscillations stabilize concentric wave patterns, thus improving signal quality. Furthermore, both lower secondary amplitude as well as noise in the oscillation period might be working against chronic inflammation, the state of self-sustained and stimulus-independent excitations. Our findings suggest that the characteristic irregular secondary oscillations of lower amplitude are not accidental. On the contrary, they might have evolved to increase robustness of the inflammatory response and the system's ability to return to a pre-stimulated state.

SMAP L-Band Microwave Radiometer: Instrument Design and First Year on Orbit

NASA Technical Reports Server (NTRS)

Piepmeier, Jeffrey R.; Focardi, Paolo; Horgan, Kevin; Knuble, Joseph; Ehsan, Negar; Lucey, Jared; Brambora, Clifford; Brown, Paula R.; Hoffman, Pamela J.; French, Richard T.;

Spatial complexity reduces interaction strengths in the meta-food web of a river floodplain mosaic

USGS Publications Warehouse

Bellmore, James Ryan; Baxter, Colden Vance; Connolly, Patrick J.

2015-01-01

Theory states that both the spatial complexity of landscapes and the strength of interactions between consumers and their resources are important for maintaining biodiversity and the 'balance of nature.' Spatial complexity is hypothesized to promote biodiversity by reducing potential for competitive exclusion; whereas, models show weak trophic interactions can enhance stability and maintain biodiversity by dampening destabilizing oscillations associated with strong interactions. Here we show that spatial complexity can reduce the strength of consumer-resource interactions in natural food webs. By sequentially aggregating food webs of individual aquatic habitat patches across a floodplain mosaic, we found that increasing spatial complexity resulted in decreases in the strength of interactions between predators and prey, owing to a greater proportion of weak interactions and a reduced proportion of strong interactions in the meta-food web. The main mechanism behind this pattern was that some patches provided predation refugia for species which were often strongly preyed upon in other patches. If weak trophic interactions do indeed promote stability, then our findings may signal an additional mechanism by which complexity and stability are linked in nature. In turn, this may have implications for how the values of landscape complexity, and the costs of biophysical homogenization, are assessed.

Recovery Discontinuous Galerkin Jacobian-Free Newton-Krylov Method for All-Speed Flows

DOE Office of Scientific and Technical Information (OSTI.GOV)

HyeongKae Park; Robert Nourgaliev; Vincent Mousseau

2008-07-01

A novel numerical algorithm (rDG-JFNK) for all-speed fluid flows with heat conduction and viscosity is introduced. The rDG-JFNK combines the Discontinuous Galerkin spatial discretization with the implicit Runge-Kutta time integration under the Jacobian-free Newton-Krylov framework. We solve fully-compressible Navier-Stokes equations without operator-splitting of hyperbolic, diffusion and reaction terms, which enables fully-coupled high-order temporal discretization. The stability constraint is removed due to the L-stable Explicit, Singly Diagonal Implicit Runge-Kutta (ESDIRK) scheme. The governing equations are solved in the conservative form, which allows one to accurately compute shock dynamics, as well as low-speed flows. For spatial discretization, we develop a “recovery” familymore » of DG, exhibiting nearly-spectral accuracy. To precondition the Krylov-based linear solver (GMRES), we developed an “Operator-Split”-(OS) Physics Based Preconditioner (PBP), in which we transform/simplify the fully-coupled system to a sequence of segregated scalar problems, each can be solved efficiently with Multigrid method. Each scalar problem is designed to target/cluster eigenvalues of the Jacobian matrix associated with a specific physics.« less

Intrinsic anharmonic effects on the phonon frequencies and effective spin-spin interactions in a quantum simulator made from trapped ions in a linear Paul trap

NASA Astrophysics Data System (ADS)

McAneny, M.; Freericks, J. K.

2014-11-01

The Coulomb repulsion between ions in a linear Paul trap gives rise to anharmonic terms in the potential energy when expanded about the equilibrium positions. We examine the effect of these anharmonic terms on the accuracy of a quantum simulator made from trapped ions. To be concrete, we consider a linear chain of Yb171+ ions stabilized close to the zigzag transition. We find that for typical experimental temperatures, frequencies change by no more than a factor of 0.01 % due to the anharmonic couplings. Furthermore, shifts in the effective spin-spin interactions (driven by a spin-dependent optical dipole force) are also, in general, less than 0.01 % for detunings to the blue of the transverse center-of-mass frequency. However, detuning the spin interactions near other frequencies can lead to non-negligible anharmonic contributions to the effective spin-spin interactions. We also examine an odd behavior exhibited by the harmonic spin-spin interactions for a range of intermediate detunings, where nearest-neighbor spins with a larger spatial separation on the ion chain interact more strongly than nearest neighbors with a smaller spatial separation.

Influence of spatial configurations on electromagnetic interference shielding of ordered mesoporous carbon/ordered mesoporous silica/silica composites

PubMed Central

Wang, Jiacheng; Zhou, Hu; Zhuang, Jiandong; Liu, Qian

2013-01-01

Ordered mesoporous carbons (OMCs), obtained by nanocasting using ordered mesoporous silicas (OMSs) as hard templates, exhibit unique arrangements of ordered regular nanopore/nanowire mesostructures. Here, we used nanocasting combined with hot-pressing to prepare 10 wt% OMC/OMS/SiO2 ternary composites possessing various carbon mesostructure configurations of different dimensionalities (1D isolated CS41 carbon nanowires, 2D hexagonal CMK-3 carbon, and 3D cubic CMK-1 carbon). The electric/dielectric properties and electromagnetic interference (EMI) shielding efficiency (SE) of the composites were influenced by spatial configurations of carbon networks. The complex permittivity and the EMI SE of the composites in the X-band frequency range decreased for the carbon mesostructures in the following order: CMK-3-filled > CMK-1-filled > CS41-filled. Our study provides technical directions for designing and preparing high-performance EMI shielding materials. Our OMC-based silica composites can be used for EMI shielding, especially in high-temperature or corrosive environments, owing to the high stability of the OMC/OMS fillers and the SiO2 matrix. Related shielding mechanisms are also discussed. PMID:24248277

Three-dimensional doubly diffusive convectons: instability and transition to complex dynamics

NASA Astrophysics Data System (ADS)

Knobloch, Edgar; Beaume, Cedric; Bergeon, Alain

2017-11-01

Doubly diffusive convection in a closed vertically extended 3D container driven by competing horizontal temperature and concentration gradients is studied. No-slip boundary conditions are imposed. The buoyancy number N = - 1 to ensure the presence of a conduction state. The primary instability is subcritical and generates two families of spatially localised steady states known as convectons. The convectons bifurcate directly from the conduction state and are organized in a pair of primary branches that snake within a well-defined range of Rayleigh numbers as the convectons grow in length. Secondary instabilities generating twist result in secondary snaking branches of twisted convectons. These destabilize the primary convectons and are responsible for the absence of stable steady states, localized or otherwise, in the subcritical regime. As a result, once the Rayleigh number for the primary instability of the conduction state is exceeded, the system exhibits an abrupt transition to large amplitude spatio-temporal chaos that arises whenever the twist instability leading to collapse is faster than the nucleation time for new rolls. These numerical results are confirmed by determining the stability properties of all convecton states as well as spatially extended convection. Supported in part by the National Science Foundation under Grant DMS-1613132.

Nanoscale Chemical Imaging of Zeolites Using Atom Probe Tomography.

PubMed

Weckhuysen, Bert Marc; Schmidt, Joel; Peng, Linqing; Poplawsky, Jonathan

2018-05-02

Understanding structure-composition-property relationships in zeolite-based materials is critical to engineering improved solid catalysts. However, this can be difficult to realize as even single zeolite crystals can exhibit heterogeneities spanning several orders of magnitude, with consequences for e.g. reactivity, diffusion as well as stability. Great progress has been made in characterizing these porous solids using tomographic techniques, though each method has an ultimate spatial resolution limitation. Atom Probe Tomography (APT) is the only technique so far capable of producing 3-D compositional reconstructions with sub-nm-scale resolution, and has only recently been applied to zeolite-based catalysts. Herein, we discuss the use of APT to study zeolites, including the critical aspects of sample preparation, data collection, assignment of mass spectral peaks including the predominant CO peak, the limitations of spatial resolution for the recovery of crystallographic information, and proper data analysis. All sections are illustrated with examples from recent literature, as well as previously unpublished data and analyses to demonstrate practical strategies to overcome potential pitfalls in applying APT to zeolites, thereby highlighting new insights gained from the APT method. © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Negative stiffness and modulated states in active nematics.

PubMed

Srivastava, Pragya; Mishra, Prashant; Marchetti, M Cristina

2016-10-04

We examine the dynamics of an active nematic liquid crystal on a frictional substrate. When frictional damping dominates over viscous dissipation, we eliminate flow in favor of active stresses to obtain a minimal dynamical model for the nematic order parameter, with elastic constants renormalized by activity. The renormalized elastic constants can become negative at large activity, leading to the selection of spatially inhomogeneous patterns via a mechanism analogous to that responsible for modulated phases arising at an equilibrium Lifshitz point. Tuning activity and the degree of nematic order in the passive system, we obtain a linear stability phase diagram that exhibits a nonequilibrium tricritical point where ordered, modulated and disordered phases meet. Numerical solution of the nonlinear equations yields a succession of spatial structures of increasing complexity with increasing activity, including kink walls and active turbulence, as observed in experiments on microtubule bundles confined at an oil-water interface. Our work provides a minimal model for an overdamped active nematic that reproduces all the nonequilibrium structures seen in simulations of the full active nematic hydrodynamics and provides a framework for understanding some of the mechanisms for selection of the nonequilibrium patterns in the language of equilibrium critical phenomena.

Organic photochromics for spatial light modulation

NASA Astrophysics Data System (ADS)

Kirkby, C. J. G.; Bennion, I.

1986-02-01

The feasibility of using fulgide derivatives (FD), a class of thermally stable, fatigue-free photochromic materials (PM), as optically addressed spatial light modulators (SLIM) is analyzed. Photochromism is the property of a material that changes from one physicochemical state to another due to the impingement of light. The PMs are low-resolution but exhibit no granularity as photographic films do, therefore permitting the use of PMs as data or image recording media with direct-read-after-write capability. It is known that the properties of the FDs (of dimethyl succinic anhydride), i.e., the fatigue, thermal stability and absorption band location, can be tailored by control of the location of two of the oxygen links at two locations on the molecule. Manipulating the absorption spectra also allows manipulation of the refractive index, ergo the SLIM capability of the FDs. Molecular substitutions have proven effective for adjustments of the wavelength sensitivities of the FDs. Film thicknesses of 3-10 microns have been shown capable of supporting a practical resolution limit of 100-200 line pairs/mm, a 30 dB dynamic range, a Fourier plane SNR of 50, and an image recycle time of 40 msec.

Numerical Bifurcation Analysis of Delayed Recycle Stream in a Continuously Stirred Tank Reactor

NASA Astrophysics Data System (ADS)

Gangadhar, Nalwala Rohitbabu; Balasubramanian, Periyasamy

2010-10-01

In this paper, we present the stability analysis of delay differential equations which arise as a result of transportation lag in the CSTR-mechanical separator recycle system. A first order irreversible elementary reaction is considered to model the system and is governed by the delay differential equations. The DDE-BIFTOOL software package is used to analyze the stability of the delay system. The present analysis reveals that the system exhibits delay independent stability for isothermal operation of the CSTR. In the absence of delay, the system is dynamically unstable for non-isothermal operation of the CSTR, and as a result of delay, the system exhibits delay dependent stability.

Children with Chromosome 22q11.2 Deletion Syndrome Exhibit Impaired Spatial Working Memory

ERIC Educational Resources Information Center

Wong, Ling M.; Riggins, Tracy; Harvey, Danielle; Cabaral, Margarita; Simon, Tony J.

2014-01-01

Individuals with chromosome 22q11.2 deletion syndrome (22q11.2DS) have been shown to have impairments in processing spatiotemporal information. The authors examined whether children with 22q11.2DS exhibit impairments in spatial working memory performance due to these weaknesses, even when controlling for maintenance of attention. Children with…

Improving specific activity and thermostability of Escherichia coli phytase by structure-based rational design.

PubMed

Wu, Tzu-Hui; Chen, Chun-Chi; Cheng, Ya-Shan; Ko, Tzu-Ping; Lin, Cheng-Yen; Lai, Hui-Lin; Huang, Ting-Yung; Liu, Je-Ruei; Guo, Rey-Ting

2014-04-10

Escherichia coli phytase (EcAppA) which hydrolyzes phytate has been widely applied in the feed industry, but the need to improve the enzyme activity and thermostability remains. Here, we conduct rational design with two strategies to enhance the EcAppA performance. First, residues near the substrate binding pocket of EcAppA were modified according to the consensus sequence of two highly active Citrobacter phytases. One out of the eleven mutants, V89T, exhibited 17.5% increase in catalytic activity, which might be a result of stabilized protein folding. Second, the EcAppA glycosylation pattern was modified in accordance with the Citrobacter phytases. An N-glycosylation motif near the substrate binding site was disrupted to remove spatial hindrance for phytate entry and product departure. The de-glycosylated mutants showed 9.6% increase in specific activity. On the other hand, the EcAppA mutants that adopt N-glycosylation motifs from CbAppA showed improved thermostability that three mutants carrying single N-glycosylation motif exhibited 5.6-9.5% residual activity after treatment at 80°C (1.8% for wild type). Furthermore, the mutant carrying all three glycosylation motifs exhibited 27% residual activity. In conclusion, a successful rational design was performed to obtain several useful EcAppA mutants with better properties for further applications. Copyright © 2014 Elsevier B.V. All rights reserved.

Food-web complexity, meta-community complexity and community stability.

PubMed

Mougi, A; Kondoh, M

2016-04-13

What allows interacting, diverse species to coexist in nature has been a central question in ecology, ever since the theoretical prediction that a complex community should be inherently unstable. Although the role of spatiality in species coexistence has been recognized, its application to more complex systems has been less explored. Here, using a meta-community model of food web, we show that meta-community complexity, measured by the number of local food webs and their connectedness, elicits a self-regulating, negative-feedback mechanism and thus stabilizes food-web dynamics. Moreover, the presence of meta-community complexity can give rise to a positive food-web complexity-stability effect. Spatiality may play a more important role in stabilizing dynamics of complex, real food webs than expected from ecological theory based on the models of simpler food webs.

Investigating the performance of LiDAR-derived biomass information in hydromechanic slope stability modelling

NASA Astrophysics Data System (ADS)

Schmaltz, Elmar; Steger, Stefan; Bogaard, Thom; Van Beek, Rens; Glade, Thomas

2017-04-01

Hydromechanic slope stability models are often used to assess the landslide susceptibility of hillslopes. Some of these models are able to account for vegetation related effects when assessing slope stability. However, spatial information of required vegetation parameters (especially of woodland) that are defined by land cover type, tree species and stand density are mostly underrepresented compared to hydropedological and geomechanical parameters. The aim of this study is to assess how LiDAR-derived biomass information can help to distinguish distinct tree stand-immanent properties (e.g. stand density and diversity) and further improve the performance of hydromechanic slope stability models. We used spatial vegetation data produced from sophisticated algorithms that are able to separate single trees within a stand based on LiDAR point clouds and thus allow an extraordinary detailed determination of the aboveground biomass. Further, this information is used to estimate the species- and stand-related distribution of the subsurface biomass using an innovative approach to approximate root system architecture and development. The hydrological tree-soil interactions and their impact on the geotechnical stability of the soil mantle are then reproduced in the dynamic and spatially distributed slope stability model STARWARS/PROBSTAB. This study highlights first advances in the approximation of biomechanical reinforcement potential of tree root systems in tree stands. Based on our findings, we address the advantages and limitations of highly detailed biomass information in hydromechanic modelling and physically based slope failure prediction.

Spatial localization in heterogeneous systems

NASA Astrophysics Data System (ADS)

Kao, Hsien-Ching; Beaume, Cédric; Knobloch, Edgar

2014-01-01

We study spatial localization in the generalized Swift-Hohenberg equation with either quadratic-cubic or cubic-quintic nonlinearity subject to spatially heterogeneous forcing. Different types of forcing (sinusoidal or Gaussian) with different spatial scales are considered and the corresponding localized snaking structures are computed. The results indicate that spatial heterogeneity exerts a significant influence on the location of spatially localized structures in both parameter space and physical space, and on their stability properties. The results are expected to assist in the interpretation of experiments on localized structures where departures from spatial homogeneity are generally unavoidable.

Calculating the wind energy input to a system using a spatially explicit method that considers atmospheric stability

EPA Science Inventory

Atmospheric stability has a major effect in determining the wind energy doing work in the atmospheric boundary layer (ABL); however, it is seldom considered in determining this value in emergy analyses. One reason that atmospheric stability is not usually considered is that a sui...

Visuotactile interaction even in far sagittal space in older adults with decreased gait and balance functions.

PubMed

Teramoto, Wataru; Honda, Keito; Furuta, Kento; Sekiyama, Kaoru

2017-08-01

Spatial proximity of signals from different sensory modalities is known to be a crucial factor in facilitating efficient multisensory processing in young adults. However, recent studies have demonstrated that older adults exhibit strong visuotactile interactions even when the visual stimuli were presented in a spatially disparate position from a tactile stimulus. This suggests that visuotactile peripersonal space differs between older and younger adults. In the present study, we investigated to what extent peripersonal space expands in the sagittal direction and whether this expansion was linked to the decline in sensorimotor functions in older adults. Vibrotactile stimuli were delivered either to the left or right index finger, while visual stimuli were presented at a distance of 5 cm (near), 37.5 cm (middle), or 70 cm (far) from each finger. The participants had to respond rapidly to a randomized sequence of unimodal (visual or tactile) and simultaneous visuotactile targets (i.e., a redundant target paradigm). Sensorimotor functions were independently assessed by the Timed Up and Go (TUG) and postural stability tests. Results showed that reaction times to the visuotactile bimodal stimuli were significantly faster than those to the unimodal stimuli, irrespective of age group [younger adults: 22.0 ± 0.6 years, older adults: 75.0 ± 3.3 years (mean ± SD)] and target distance. Of importance, a race model analysis revealed that the co-activation model (i.e., visuotactile multisensory integrative process) is supported in the far condition especially for older adults with relatively poor performance on the TUG or postural stability tests. These results suggest that aging can change visuotactile peripersonal space and that it may be closely linked to declines in sensorimotor functions related to gait and balance in older adults.

Decentralized Fuzzy MPC on Spatial Power Control of a Large PHWR

NASA Astrophysics Data System (ADS)

Liu, Xiangjie; Jiang, Di; Lee, Kwang Y.

2016-08-01

Reliable power control for stabilizing the spatial oscillations is quite important for ensuring the safe operation of a modern pressurized heavy water reactor (PHWR), since these spatial oscillations can cause “flux tilting” in the reactor core. In this paper, a decentralized fuzzy model predictive control (DFMPC) is proposed for spatial control of PHWR. Due to the load dependent dynamics of the nuclear power plant, fuzzy modeling is used to approximate the nonlinear process. A fuzzy Lyapunov function and “quasi-min-max” strategy is utilized in designing the DFMPC, to reduce the conservatism. The plant-wide stability is achieved by the asymptotically positive realness constraint (APRC) for this decentralized MPC. The solving optimization problem is based on a receding horizon scheme involving the linear matrix inequalities (LMIs) technique. Through dynamic simulations, it is demonstrated that the designed DFMPC can effectively suppress spatial oscillations developed in PHWR, and further, shows the advantages over the typical parallel distributed compensation (PDC) control scheme.

Sharp wave ripples during learning stabilize hippocampal spatial map

PubMed Central

Roux, Lisa; Hu, Bo; Eichler, Ronny; Stark, Eran; Buzsáki, György

2017-01-01

Cognitive representation of the environment requires a stable hippocampal map but the mechanisms maintaining map representation are unknown. Because sharp wave-ripples (SPW-R) orchestrate both retrospective and prospective spatial information, we hypothesized that disrupting neuronal activity during SPW-Rs affects spatial representation. Mice learned daily a new set of three goal locations on a multi-well maze. We used closed-loop SPW-R detection at goal locations to trigger optogenetic silencing of a subset of CA1 pyramidal neurons. Control place cells (non-silenced or silenced outside SPW-Rs) largely maintained the location of their place fields after learning and showed increased spatial information content. In contrast, the place fields of SPW-R-silenced place cells remapped, and their spatial information remained unaltered. SPW-R silencing did not impact the firing rates or the proportions of place cells. These results suggest that interference with SPW-R-associated activity during learning prevents the stabilization and refinement of the hippocampal map. PMID:28394323

Computational models of spatial updating in peri-saccadic perception

PubMed Central

Hamker, Fred H.; Zirnsak, Marc; Ziesche, Arnold; Lappe, Markus

2011-01-01

Perceptual phenomena that occur around the time of a saccade, such as peri-saccadic mislocalization or saccadic suppression of displacement, have often been linked to mechanisms of spatial stability. These phenomena are usually regarded as errors in processes of trans-saccadic spatial transformations and they provide important tools to study these processes. However, a true understanding of the underlying brain processes that participate in the preparation for a saccade and in the transfer of information across it requires a closer, more quantitative approach that links different perceptual phenomena with each other and with the functional requirements of ensuring spatial stability. We review a number of computational models of peri-saccadic spatial perception that provide steps in that direction. Although most models are concerned with only specific phenomena, some generalization and interconnection between them can be obtained from a comparison. Our analysis shows how different perceptual effects can coherently be brought together and linked back to neuronal mechanisms on the way to explaining vision across saccades. PMID:21242143

Strategy Diversity Stabilizes Mutualism through Investment Cycles, Phase Polymorphism, and Spatial Bubbles

PubMed Central

Boza, Gergely; Kun, Ádám; Scheuring, István; Dieckmann, Ulf

2012-01-01

There is continuing interest in understanding factors that facilitate the evolution and stability of cooperation within and between species. Such interactions will often involve plasticity in investment behavior, in response to the interacting partner's investments. Our aim here is to investigate the evolution and stability of reciprocal investment behavior in interspecific interactions, a key phenomenon strongly supported by experimental observations. In particular, we present a comprehensive analysis of a continuous reciprocal investment game between mutualists, both in well-mixed and spatially structured populations, and we demonstrate a series of novel mechanisms for maintaining interspecific mutualism. We demonstrate that mutualistic partners invariably follow investment cycles, during which mutualism first increases, before both partners eventually reduce their investments to zero, so that these cycles always conclude with full defection. We show that the key mechanism for stabilizing mutualism is phase polymorphism along the investment cycle. Although mutualistic partners perpetually change their strategies, the community-level distribution of investment levels becomes stationary. In spatially structured populations, the maintenance of polymorphism is further facilitated by dynamic mosaic structures, in which mutualistic partners form expanding and collapsing spatial bubbles or clusters. Additionally, we reveal strategy-diversity thresholds, both for well-mixed and spatially structured mutualistic communities, and discuss factors for meeting these thresholds, and thus maintaining mutualism. Our results demonstrate that interspecific mutualism, when considered as plastic investment behavior, can be unstable, and, in agreement with empirical observations, may involve a polymorphism of investment levels, varying both in space and in time. Identifying the mechanisms maintaining such polymorphism, and hence mutualism in natural communities, provides a significant step towards understanding the coevolution and population dynamics of mutualistic interactions. PMID:23166478

Strategy diversity stabilizes mutualism through investment cycles, phase polymorphism, and spatial bubbles.

PubMed

Boza, Gergely; Kun, Adám; Scheuring, István; Dieckmann, Ulf

2012-01-01

There is continuing interest in understanding factors that facilitate the evolution and stability of cooperation within and between species. Such interactions will often involve plasticity in investment behavior, in response to the interacting partner's investments. Our aim here is to investigate the evolution and stability of reciprocal investment behavior in interspecific interactions, a key phenomenon strongly supported by experimental observations. In particular, we present a comprehensive analysis of a continuous reciprocal investment game between mutualists, both in well-mixed and spatially structured populations, and we demonstrate a series of novel mechanisms for maintaining interspecific mutualism. We demonstrate that mutualistic partners invariably follow investment cycles, during which mutualism first increases, before both partners eventually reduce their investments to zero, so that these cycles always conclude with full defection. We show that the key mechanism for stabilizing mutualism is phase polymorphism along the investment cycle. Although mutualistic partners perpetually change their strategies, the community-level distribution of investment levels becomes stationary. In spatially structured populations, the maintenance of polymorphism is further facilitated by dynamic mosaic structures, in which mutualistic partners form expanding and collapsing spatial bubbles or clusters. Additionally, we reveal strategy-diversity thresholds, both for well-mixed and spatially structured mutualistic communities, and discuss factors for meeting these thresholds, and thus maintaining mutualism. Our results demonstrate that interspecific mutualism, when considered as plastic investment behavior, can be unstable, and, in agreement with empirical observations, may involve a polymorphism of investment levels, varying both in space and in time. Identifying the mechanisms maintaining such polymorphism, and hence mutualism in natural communities, provides a significant step towards understanding the coevolution and population dynamics of mutualistic interactions.

Figure–ground discrimination behavior in Drosophila. I. Spatial organization of wing-steering responses

PubMed Central

Fox, Jessica L.; Aptekar, Jacob W.; Zolotova, Nadezhda M.; Shoemaker, Patrick A.; Frye, Mark A.

2014-01-01

The behavioral algorithms and neural subsystems for visual figure–ground discrimination are not sufficiently described in any model system. The fly visual system shares structural and functional similarity with that of vertebrates and, like vertebrates, flies robustly track visual figures in the face of ground motion. This computation is crucial for animals that pursue salient objects under the high performance requirements imposed by flight behavior. Flies smoothly track small objects and use wide-field optic flow to maintain flight-stabilizing optomotor reflexes. The spatial and temporal properties of visual figure tracking and wide-field stabilization have been characterized in flies, but how the two systems interact spatially to allow flies to actively track figures against a moving ground has not. We took a systems identification approach in flying Drosophila and measured wing-steering responses to velocity impulses of figure and ground motion independently. We constructed a spatiotemporal action field (STAF) – the behavioral analog of a spatiotemporal receptive field – revealing how the behavioral impulse responses to figure tracking and concurrent ground stabilization vary for figure motion centered at each location across the visual azimuth. The figure tracking and ground stabilization STAFs show distinct spatial tuning and temporal dynamics, confirming the independence of the two systems. When the figure tracking system is activated by a narrow vertical bar moving within the frontal field of view, ground motion is essentially ignored despite comprising over 90% of the total visual input. PMID:24198267

In-situ confined formation of NiFe layered double hydroxide quantum dots in expanded graphite for active electrocatalytic oxygen evolution

NASA Astrophysics Data System (ADS)

Guo, Jinxue; Li, Xiaoyan; Sun, Yanfang; Liu, Qingyun; Quan, Zhenlan; Zhang, Xiao

2018-06-01

Development of noble-metal-free catalysts towards highly efficient electrochemical oxygen evolution reaction (OER) is critical but challenging in the renewable energy area. Herein, we firstly embed NiFe LDHs quantum dots (QDs) into expanded graphite (NiFe LDHs/EG) via in-situ confined formation process. The interlayer spacing of EG layers acts as nanoreactors for spatially confined formation of NiFe LDHs QDs. The QDs supply huge catalytic sites for OER. The in-situ decoration endows the strong affinity between QDs with EG, thus inducing fast charge transfer. Based on the aforementioned benefits, the designed catalyst exhibits outstanding OER properties, in terms of small overpotential (220 mV required to generate 10 mA cm-2), low Tafel slope, and good durable stability, making it a promising candidate for inexpensive OER catalyst.

Dynamics of cortical dendritic membrane potential and spikes in freely behaving rats.

PubMed

Moore, Jason J; Ravassard, Pascal M; Ho, David; Acharya, Lavanya; Kees, Ashley L; Vuong, Cliff; Mehta, Mayank R

2017-03-24

Neural activity in vivo is primarily measured using extracellular somatic spikes, which provide limited information about neural computation. Hence, it is necessary to record from neuronal dendrites, which can generate dendritic action potentials (DAPs) in vitro, which can profoundly influence neural computation and plasticity. We measured neocortical sub- and suprathreshold dendritic membrane potential (DMP) from putative distal-most dendrites using tetrodes in freely behaving rats over multiple days with a high degree of stability and submillisecond temporal resolution. DAP firing rates were several-fold larger than somatic rates. DAP rates were also modulated by subthreshold DMP fluctuations, which were far larger than DAP amplitude, indicating hybrid, analog-digital coding in the dendrites. Parietal DAP and DMP exhibited egocentric spatial maps comparable to pyramidal neurons. These results have important implications for neural coding and plasticity. Copyright © 2017, American Association for the Advancement of Science.

Self ordering threshold and superradiant backscattering to slow a fast gas beam in a ring cavity with counter propagating pump

NASA Astrophysics Data System (ADS)

Maes, C.; Asbóth, J. K.; Ritsch, H.

2007-05-01

We study the dynamics of a fast gaseous beam in a high Q ring cavity counter propagating a strong pump laser with large detuning from any particle optical resonance. As spontaneous emission is strongly suppressed the particles can be treated as polarizable point masses forming a dynamic moving mirror. Above a threshold intensity the particles exhibit spatial periodic ordering enhancing collective coherent backscattering which decelerates the beam. Based on a linear stability analysis in their accelerated rest frame we derive analytic bounds for the intensity threshold of this selforganization as a function of particle number, average velocity, kinetic temperature, pump detuning and resonator linewidth. The analytical results agree well with time dependent simulations of the N-particle motion including field damping and spontaneous emission noise. Our results give conditions which may be easily evaluated for stopping and cooling a fast molecular beam.

Pattern selection in solidification

NASA Technical Reports Server (NTRS)

Langer, J. S.

1984-01-01

Directional solidification of alloys produces a wide variety of cellular or lamellar structures which, depending upon growth conditions, may be reproducibly regular or may behave chaotically. It is not well understood how these patterns are selected and controlled or even whether there ever exist sharp selection mechanisms. A related phenomenon is the spatial propagation of a pattern into a system which has been caused to become unstable against pattern-forming deformations. This phenomenon has some features in common with the propagation of sidebranching modes in dendritic solidification. In a class of one-dimensional models, the nonlinear system can be shown to select the propagating mode in which the leading edge of the pattern is just marginally stable. This stability principle, when applicable, predicts both the speed of propagation and the geometrical characteristics of the pattern which forms behind the moving front. A boundary-layer model for fully two or three dimensional solidification problems appears to exhibit similar mathematical behavior.

Low-energy planar magnetic defects in BaFe 2 As 2 : Nanotwins, twins, antiphase, and domain boundaries

DOE Office of Scientific and Technical Information (OSTI.GOV)

Khan, S. N.; Alam, Aftab; Johnson, Duane D.

2013-11-27

In BaFe 2As 2, structural and magnetic planar defects begin to proliferate below the structural phase transition, affecting descriptions of magnetism and superconductivity. We study, using density-functional theory, the stability and magnetic properties of competing antiphase and domain boundaries, twins and isolated nanotwins (twin nuclei), and spin excitations proposed and/or observed. These nanoscale defects have a very low surface energy (22–210 m Jm -2), with twins favorable to the mesoscale. Defects exhibit smaller moments confined near their boundaries—making a uniform-moment picture inappropriate for long-range magnetic order in real samples. Nanotwins explain features in measured pair distribution functions so should bemore » considered when analyzing scattering data. All these defects can be weakly mobile and/or can have fluctuations that lower assessed “ordered” moments from longer spatial and/or time averaging and should be considered directly.« less

Self ordering threshold and superradiant backscattering to slow a fast gas beam in a ring cavity with counter propagating pump.

PubMed

Maes, C; Asbóth, J K; Ritsch, H

2007-05-14

We study the dynamics of a fast gaseous beam in a high Q ring cavity counter propagating a strong pump laser with large detuning from any particle optical resonance. As spontaneous emission is strongly suppressed the particles can be treated as polarizable point masses forming a dynamic moving mirror. Above a threshold intensity the particles exhibit spatial periodic ordering enhancing collective coherent backscattering which decelerates the beam. Based on a linear stability analysis in their accelerated rest frame we derive analytic bounds for the intensity threshold of this selforganization as a function of particle number, average velocity, kinetic temperature, pump detuning and resonator linewidth. The analytical results agree well with time dependent simulations of the N-particle motion including field damping and spontaneous emission noise. Our results give conditions which may be easily evaluated for stopping and cooling a fast molecular beam.

A trabecular metal implant 4 months after placement: clinical-histologic case report.

PubMed

Spinato, Sergio; Zaffe, Davide; Felice, Pietro; Checchi, Luigi; Wang, Hom-Lay

2014-02-01

The aim of this case report was to histologically evaluate the behavior of a trabecular metal (TM) implant composed of titanium and spatial 3-dimensional tantalum (Ta) trabeculae. This study is the first human histologic case report of this implant. A TM implant was placed in a 54-year-old woman exhibiting moderate chronic periodontitis. After periodontal treatment, the implant was inserted under favorable clinical conditions. Patient was not seen for 4 months because of unrelated breast reduction surgery. At the surgical reopening, periimplant inflammation affecting the coronal third of the implant was observed 4 months after implant placement. With patient's consent, the implant was removed for histologic analysis. Histology highlighted a greater amount of bone in close contact with Ta trabeculae than titanium surfaces. The finding of bone formation around the Ta trabeculae suggests that trabecular metal material promotes bone ingrowth for secondary implant stability. Additional evidence is needed to confirm this observation.

Clk post-transcriptional control denoises circadian transcription both temporally and spatially.

PubMed

Lerner, Immanuel; Bartok, Osnat; Wolfson, Victoria; Menet, Jerome S; Weissbein, Uri; Afik, Shaked; Haimovich, Daniel; Gafni, Chen; Friedman, Nir; Rosbash, Michael; Kadener, Sebastian

2015-05-08

The transcription factor CLOCK (CLK) is essential for the development and maintenance of circadian rhythms in Drosophila. However, little is known about how CLK levels are controlled. Here we show that Clk mRNA is strongly regulated post-transcriptionally through its 3' UTR. Flies expressing Clk transgenes without normal 3' UTR exhibit variable CLK-driven transcription and circadian behaviour as well as ectopic expression of CLK-target genes in the brain. In these flies, the number of the key circadian neurons differs stochastically between individuals and within the two hemispheres of the same brain. Moreover, flies carrying Clk transgenes with deletions in the binding sites for the miRNA bantam have stochastic number of pacemaker neurons, suggesting that this miRNA mediates the deterministic expression of CLK. Overall our results demonstrate a key role of Clk post-transcriptional control in stabilizing circadian transcription, which is essential for proper development and maintenance of circadian rhythms in Drosophila.

The Influence of Visual Experience on the Ability to Form Spatial Mental Models Based on Route and Survey Descriptions

ERIC Educational Resources Information Center

Noordzij, Matthijs L.; Zuidhoek, Sander; Postma, Albert

2006-01-01

The purpose of the present study is twofold: the first objective is to evaluate the importance of visual experience for the ability to form a spatial representation (spatial mental model) of fairly elaborate spatial descriptions. Secondly, we examine whether blind people exhibit the same preferences (i.e. level of performance on spatial tasks) as…

Trait-mediated assembly processes predict successional changes in community diversity of tropical forests.

PubMed

Lasky, Jesse R; Uriarte, María; Boukili, Vanessa K; Chazdon, Robin L

2014-04-15

Interspecific differences in relative fitness can cause local dominance by a single species. However, stabilizing interspecific niche differences can promote local diversity. Understanding these mechanisms requires that we simultaneously quantify their effects on demography and link these effects to community dynamics. Successional forests are ideal systems for testing assembly theory because they exhibit rapid community assembly. Here, we leverage functional trait and long-term demographic data to build spatially explicit models of successional community dynamics of lowland rainforests in Costa Rica. First, we ask what the effects and relative importance of four trait-mediated community assembly processes are on tree survival, a major component of fitness. We model trait correlations with relative fitness differences that are both density-independent and -dependent in addition to trait correlations with stabilizing niche differences. Second, we ask how the relative importance of these trait-mediated processes relates to successional changes in functional diversity. Tree dynamics were more strongly influenced by trait-related interspecific variation in average survival than trait-related responses to neighbors, with wood specific gravity (WSG) positively correlated with greater survival. Our findings also suggest that competition was mediated by stabilizing niche differences associated with specific leaf area (SLA) and leaf dry matter content (LDMC). These drivers of individual-level survival were reflected in successional shifts to higher SLA and LDMC diversity but lower WSG diversity. Our study makes significant advances to identifying the links between individual tree performance, species functional traits, and mechanisms of tropical forest succession.

The Structural and Rank-Order Stability of Temperament in Young Children Based on a Laboratory-Observational Measure

PubMed Central

Dyson, Margaret W.; Olino, Thomas M.; Durbin, C. Emily; Goldsmith, H. Hill; Bufferd, Sara J.; Miller, Anna R.; Klein, Daniel N.

2015-01-01

It is generally assumed that temperament traits exhibit structural and rank-order stability over time. Most of the research on structural and rank-order stability has relied on parent-report measures. The present study used an alternative approach, a laboratory-observational measure (Laboratory Temperament Assessment Battery [Lab-TAB]), to examine the structural and rank-order stability of temperament traits in a community sample of young children (N = 447). Using structural equation modeling (SEM), we found that a similar five-factor structure consisting of the dimensions of Positive Affect/Interest, Sociability, Dysphoria, Fear/Inhibition, and Impulsivity vs. Constraint provided an adequate fit to the data at both age 3 and 6 years, suggesting good structural stability. Moreover, all five latent factors exhibited significant, albeit modest, rank-order stability from age 3 to 6. In addition, there were significant heterotypic associations of age 3 Sociability with age 6 PA/Interest, and age 3 Impulsivity vs. Constraint with age 6 Fear/Inhibition. PMID:25894709

Role of high-order aberrations in senescent changes in spatial vision

DOE Office of Scientific and Technical Information (OSTI.GOV)

Elliot, S; Choi, S S; Doble, N

2009-01-06

The contributions of optical and neural factors to age-related losses in spatial vision are not fully understood. We used closed-loop adaptive optics to test the visual benefit of correcting monochromatic high-order aberrations (HOAs) on spatial vision for observers ranging in age from 18-81 years. Contrast sensitivity was measured monocularly using a two-alternative forced choice (2AFC) procedure for sinusoidal gratings over 6 mm and 3 mm pupil diameters. Visual acuity was measured using a spatial 4AFC procedure. Over a 6 mm pupil, young observers showed a large benefit of AO at high spatial frequencies, whereas older observers exhibited the greatest benefitmore » at middle spatial frequencies, plus a significantly larger increase in visual acuity. When age-related miosis is controlled, young and old observers exhibited a similar benefit of AO for spatial vision. An increase in HOAs cannot account for the complete senescent decline in spatial vision. These results may indicate a larger role of additional optical factors when the impact of HOAs is removed, but also lend support for the importance of neural factors in age-related changes in spatial vision.« less

Spatial optimal disturbances in swept-wing boundary layers

NASA Astrophysics Data System (ADS)

Chen, Cheng

2018-04-01

With the use of the adjoint-based optimization method proposed by Tempelmann et al. (J. Fluid Mech., vol. 704, 2012, pp. 251-279), in which the parabolized stability equation (PSE) and so-called adjoint parabolized stability equation (APSE) are solved iteratively, we obtain the spatial optimal disturbance shape and investigate its dependence on the parameters of disturbance wave and wall condition, such as radial frequency ω and wall temperature Twall, in a swept-wing boundary layer flow. Further, the non-modal growth mechanism of this optimal disturbance has been also discussed, regarding its spatial evolution way in the streamwise direction. The results imply that the spanwise wavenumber, disturbance frequency and wall cooling do not change the physical mechanism of perturbation growth, just with a substantial effect on the magnitude of perturbation growth. Further, wall cooling may have enhancing or suppressing effect on spatial optimal disturbance growth, depending on the streamwise location.

DNA methylation regulates neurophysiological spatial representation in memory formation

PubMed Central

Roth, Eric D.; Roth, Tania L.; Money, Kelli M.; SenGupta, Sonda; Eason, Dawn E.; Sweatt, J. David

2015-01-01

Epigenetic mechanisms including altered DNA methylation are critical for altered gene transcription subserving synaptic plasticity and the retention of learned behavior. Here we tested the idea that one role for activity-dependent altered DNA methylation is stabilization of cognition-associated hippocampal place cell firing in response to novel place learning. We observed that a behavioral protocol (spatial exploration of a novel environment) known to induce hippocampal place cell remapping resulted in alterations of hippocampal Bdnf DNA methylation. Further studies using neurophysiological in vivo single unit recordings revealed that pharmacological manipulations of DNA methylation decreased long-term but not short-term place field stability. Together our data highlight a role for DNA methylation in regulating neurophysiological spatial representation and memory formation. PMID:25960947

Does stability in local community composition depend on temporal variation in rates of dispersal and connectivity?

NASA Astrophysics Data System (ADS)

Valanko, Sebastian; Norkko, Joanna; Norkko, Alf

2015-04-01

In ecology understanding variation in connectivity is central for how biodiversity is maintained. Field studies on dispersal and temporal dynamics in community regulating processes are, however, rare. We test the short-term temporal stability in community composition in a soft-sediment benthic community by determining among-sampling interval similarity in community composition. We relate stability to in situ measures of connectivity (wind, wave, current energy) and rates of dispersal (quantified in different trap types). Waves were an important predictor of when local community taxa are most likely to disperse in different trap-types, suggesting that wave energy is important for connectivity in a region. Community composition at the site was variable and changed stochastically over time. We found changes in community composition (occurrence, abundance, dominance) to be greater at times when connectivity and rates of dispersal were low. In response to periods of lower connectedness dominant taxa in the local community only exhibited change in their relative abundance. In contrast, locally less abundant taxa varied in both their presence, as well as in relative abundance. Constancy in connectivity and rates of dispersal promotes community stability and persistence, suggesting that local community composition will be impacted by changes in the spatial extent over which immigration and emigration operates in the region. Few empirical studies have actually measured dispersal directly in a multi-species context to demonstrate the role it plays in maintaining local community structure. Even though our study does not evaluate coexistence over demographic time scales, it importantly demonstrates that dispersal is not only important in initial recruitment or following a disturbance, but also key in maintaining local community composition.

Hysteresis, phase transitions, and dangerous transients in electrical power distribution systems

NASA Astrophysics Data System (ADS)

Duclut, Charlie; Backhaus, Scott; Chertkov, Michael

2013-06-01

The majority of dynamical studies in power systems focus on the high-voltage transmission grids where models consider large generators interacting with crude aggregations of individual small loads. However, new phenomena have been observed indicating that the spatial distribution of collective, nonlinear contribution of these small loads in the low-voltage distribution grid is crucial to the outcome of these dynamical transients. To elucidate the phenomenon, we study the dynamics of voltage and power flows in a spatially extended distribution feeder (circuit) connecting many asynchronous induction motors and discover that this relatively simple 1+1 (space+time) dimensional system exhibits a plethora of nontrivial spatiotemporal effects, some of which may be dangerous for power system stability. Long-range motor-motor interactions mediated by circuit voltage and electrical power flows result in coexistence and segregation of spatially extended phases defined by individual motor states, a “normal” state where the motors’ mechanical (rotation) frequency is slightly smaller than the nominal frequency of the basic ac flows and a “stalled” state where the mechanical frequency is small. Transitions between the two states can be initiated by a perturbation of the voltage or base frequency at the head of the distribution feeder. Such behavior is typical of first-order phase transitions in physics, and this 1+1 dimensional model shows many other properties of a first-order phase transition with the spatial distribution of the motors’ mechanical frequency playing the role of the order parameter. In particular, we observe (a) propagation of the phase-transition front with the constant speed (in very long feeders) and (b) hysteresis in transitions between the normal and stalled (or partially stalled) phases.

Robust doubly charged nodal lines and nodal surfaces in centrosymmetric systems

NASA Astrophysics Data System (ADS)

Bzdušek, Tomáš; Sigrist, Manfred

2017-10-01

Weyl points in three spatial dimensions are characterized by a Z -valued charge—the Chern number—which makes them stable against a wide range of perturbations. A set of Weyl points can mutually annihilate only if their net charge vanishes, a property we refer to as robustness. While nodal loops are usually not robust in this sense, it has recently been shown using homotopy arguments that in the centrosymmetric extension of the AI symmetry class they nevertheless develop a Z2 charge analogous to the Chern number. Nodal loops carrying a nontrivial value of this Z2 charge are robust, i.e., they can be gapped out only by a pairwise annihilation and not on their own. As this is an additional charge independent of the Berry π -phase flowing along the band degeneracy, such nodal loops are, in fact, doubly charged. In this manuscript, we generalize the homotopy discussion to the centrosymmetric extensions of all Atland-Zirnbauer classes. We develop a tailored mathematical framework dubbed the AZ +I classification and show that in three spatial dimensions such robust and multiply charged nodes appear in four of such centrosymmetric extensions, namely, AZ +I classes CI and AI lead to doubly charged nodal lines, while D and BDI support doubly charged nodal surfaces. We remark that no further crystalline symmetries apart from the spatial inversion are necessary for their stability. We provide a description of the corresponding topological charges, and develop simple tight-binding models of various semimetallic and superconducting phases that exhibit these nodes. We also indicate how the concept of robust and multiply charged nodes generalizes to other spatial dimensions.

Hysteresis, phase transitions, and dangerous transients in electrical power distribution systems.

PubMed

Duclut, Charlie; Backhaus, Scott; Chertkov, Michael

2013-06-01

The majority of dynamical studies in power systems focus on the high-voltage transmission grids where models consider large generators interacting with crude aggregations of individual small loads. However, new phenomena have been observed indicating that the spatial distribution of collective, nonlinear contribution of these small loads in the low-voltage distribution grid is crucial to the outcome of these dynamical transients. To elucidate the phenomenon, we study the dynamics of voltage and power flows in a spatially extended distribution feeder (circuit) connecting many asynchronous induction motors and discover that this relatively simple 1+1 (space+time) dimensional system exhibits a plethora of nontrivial spatiotemporal effects, some of which may be dangerous for power system stability. Long-range motor-motor interactions mediated by circuit voltage and electrical power flows result in coexistence and segregation of spatially extended phases defined by individual motor states, a "normal" state where the motors' mechanical (rotation) frequency is slightly smaller than the nominal frequency of the basic ac flows and a "stalled" state where the mechanical frequency is small. Transitions between the two states can be initiated by a perturbation of the voltage or base frequency at the head of the distribution feeder. Such behavior is typical of first-order phase transitions in physics, and this 1+1 dimensional model shows many other properties of a first-order phase transition with the spatial distribution of the motors' mechanical frequency playing the role of the order parameter. In particular, we observe (a) propagation of the phase-transition front with the constant speed (in very long feeders) and (b) hysteresis in transitions between the normal and stalled (or partially stalled) phases.

The ring residue proline 8 is crucial for the thermal stability of the lasso peptide caulosegnin II.

PubMed

Hegemann, Julian D; Fage, Christopher D; Zhu, Shaozhou; Harms, Klaus; Di Leva, Francesco Saverio; Novellino, Ettore; Marinelli, Luciana; Marahiel, Mohamed A

2016-04-01

Lasso peptides are fascinating natural products with a unique structural fold that can exhibit tremendous thermal stability. Here, we investigate factors responsible for the thermal stability of caulosegnin II. By employing X-ray crystallography, mutational analysis and molecular dynamics simulations, the ring residue proline 8 was proven to be crucial for thermal stability.

One-year stability for a glucose/oxygen biofuel cell combined with pH reactivation of the laccase/carbon nanotube biocathode.

PubMed

Reuillard, Bertrand; Abreu, Caroline; Lalaoui, Noémie; Le Goff, Alan; Holzinger, Michael; Ondel, Olivier; Buret, Francois; Cosnier, Serge

2015-12-01

This study reports a mixed operational/storage stability of a MWCNT-based glucose biofuel cell (GBFC) over one year. The latter was examined by performing a one hour discharge every day during one month followed by several discharges over a period of 11 months. Under continuous discharge in physiological conditions (5 mM glucose, 37°, pH7), the GBFC exhibits a 25% power decrease after 1 h of operation. This decrease is mainly due to the deactivation of laccase biocathodes at neutral pH. Nevertheless, the biocathodes can be reversibly reactivated via storage in phosphate buffer (pH 5). Under these conditions, the GBFC finally exhibits 22% of its initial maximum power density after one year at intermittent reactivation/discharge cycles. Although both GBFC electrodes can exhibit one year stability, short-term experiments show that biocathodes are limited by hydroxide inhibition while long-term experiments indicate that bioanodes are likely limited by the stability of the GOx itself. While most of the GBFCs in the literature present stability in the range of several weeks, these results demonstrate the viability of a GBFC for industrial applications in a long period of time. Copyright © 2015 Elsevier B.V. All rights reserved.

Stability in the metamemory realism of eyewitness confidence judgments.

PubMed

Buratti, Sandra; Allwood, Carl Martin; Johansson, Marcus

2014-02-01

The stability of eyewitness confidence judgments over time in regard to their reported memory and accuracy of these judgments is of interest in forensic contexts because witnesses are often interviewed many times. The present study investigated the stability of the confidence judgments of memory reports of a witnessed event and of the accuracy of these judgments over three occasions, each separated by 1 week. Three age groups were studied: younger children (8-9 years), older children (10-11 years), and adults (19-31 years). A total of 93 participants viewed a short film clip and were asked to answer directed two-alternative forced-choice questions about the film clip and to confidence judge each answer. Different questions about details in the film clip were used on each of the three test occasions. Confidence as such did not exhibit stability over time on an individual basis. However, the difference between confidence and proportion correct did exhibit stability across time, in terms of both over/underconfidence and calibration. With respect to age, the adults and older children exhibited more stability than the younger children for calibration. Furthermore, some support for instability was found with respect to the difference between the average confidence level for correct and incorrect answers (slope). Unexpectedly, however, the younger children's slope was found to be more stable than the adults. Compared to the previous research, the present study's use of more advanced statistical methods provides a more nuanced understanding of the stability of confidence judgments in the eyewitness reports of children and adults.

Stability of semidiscrete approximations for hyperbolic initial-boundary-value problems: An eigenvalue analysis

NASA Technical Reports Server (NTRS)

Warming, Robert F.; Beam, Richard M.

1986-01-01

A hyperbolic initial-boundary-value problem can be approximated by a system of ordinary differential equations (ODEs) by replacing the spatial derivatives by finite-difference approximations. The resulting system of ODEs is called a semidiscrete approximation. A complication is the fact that more boundary conditions are required for the spatially discrete approximation than are specified for the partial differential equation. Consequently, additional numerical boundary conditions are required and improper treatment of these additional conditions can lead to instability. For a linear initial-boundary-value problem (IBVP) with homogeneous analytical boundary conditions, the semidiscrete approximation results in a system of ODEs of the form du/dt = Au whose solution can be written as u(t) = exp(At)u(O). Lax-Richtmyer stability requires that the matrix norm of exp(At) be uniformly bounded for O less than or = t less than or = T independent of the spatial mesh size. Although the classical Lax-Richtmyer stability definition involves a conventional vector norm, there is no known algebraic test for the uniform boundedness of the matrix norm of exp(At) for hyperbolic IBVPs. An alternative but more complicated stability definition is used in the theory developed by Gustafsson, Kreiss, and Sundstrom (GKS). The two methods are compared.

Temporal and spatial stability of red-tailed hawk territories in the Luquillo Experimental Forest, Puerto Rico

USGS Publications Warehouse

Boal, C.W.; Snyder, H.A.; Bibles, Brent D.; Estabrook, T.S.

2003-01-01

We mapped Red-tailed Hawk (Buteo jamaicensis) territories in the Luquillo Experimental Forest (LEF) of Puerto Rico in 1998. We combined our 1998 data with that collected during previous studies of Red-tailed Hawks in the LEF to examine population numbers and spatial stability of territorial boundaries over a 26-yr period. We also investigated potential relationships between Red-tailed Hawk territory sizes and topographic and climatic factors. Mean size of 16 defended territories during 1998 was 124.3 ?? 12.0 ha, which was not significantly different from our calculations of mean territory sizes derived from data collected in 1974 and 1984. Aspect and slope influenced territory size with the smallest territories having high slope and easterly aspects. Territory size was small compared to that reported for other parts of the species' range. In addition, there was remarkably little temporal change in the spatial distribution, area, and boundaries of Red-tailed Hawk territories among the study periods. Further, there was substantial boundary overlap (21-27%) between defended territories among the different study periods. The temporal stability of the spatial distribution of Red-tailed Hawk territories in the study area leads us to believe the area might be at or near saturation.

Wide-Band Spatially Tunable Photonic Bandgap in Visible Spectral Range and Laser based on a Polymer Stabilized Blue Phase

PubMed Central

Lin, Jia-De; Wang, Tsai-Yen; Mo, Ting-Shan; Huang, Shuan-Yu; Lee, Chia-Rong

2016-01-01

This work successfully develops a largely-gradient-pitched polymer-stabilized blue phase (PSBP) photonic bandgap (PBG) device with a wide-band spatial tunability in nearly entire visible region within a wide blue phase (BP) temperature range including room temperature. The device is fabricated based on the reverse diffusion of two injected BP-monomer mixtures with a low and a high chiral concentrations and afterwards through UV-curing. This gradient-pitched PSBP can show a rainbow-like reflection appearance in which the peak wavelength of the PBG can be spatially tuned from the blue to the red regions at room temperature. The total tuning spectral range for the cell is as broad as 165 nm and covers almost the entire visible region. Based on the gradient-pitched PSBP, a spatially tunable laser is also demonstrated in this work. The temperature sensitivity of the lasing wavelength for the laser is negatively linear and approximately −0.26 nm/°C. The two devices have a great potential for use in applications of photonic devices and displays because of their multiple advantages, such as wide-band tunability, wide operated temperature range, high stability and reliability, no issue of hysteresis, no need of external controlling sources, and not slow tuning speed (mechanically). PMID:27456475

Diversity, Stability, and Reproducibility in Stochastically Assembled Microbial Ecosystems

NASA Astrophysics Data System (ADS)

Goyal, Akshit; Maslov, Sergei

2018-04-01

Microbial ecosystems are remarkably diverse, stable, and usually consist of a mixture of core and peripheral species. Here we propose a conceptual model exhibiting all these emergent properties in quantitative agreement with real ecosystem data, specifically species abundance and prevalence distributions. Resource competition and metabolic commensalism drive the stochastic ecosystem assembly in our model. We demonstrate that even when supplied with just one resource, ecosystems can exhibit high diversity, increasing stability, and partial reproducibility between samples.

Tree species exhibit complex patterns of distribution in bottomland hardwood forests

Treesearch

Luben D Dimov; Jim L Chambers; Brian R. Lockhart

2013-01-01

& Context Understanding tree interactions requires an insight into their spatial distribution. & Aims We looked for presence and extent of tree intraspecific spatial point pattern (random, aggregated, or overdispersed) and interspecific spatial point pattern (independent, aggregated, or segregated). & Methods We established twelve 0.64-ha plots in natural...

Chimpanzees and Bonobos Exhibit Divergent Spatial Memory Development

ERIC Educational Resources Information Center

Rosati, Alexandra G.; Hare, Brian

2012-01-01

Spatial cognition and memory are critical cognitive skills underlying foraging behaviors for all primates. While the emergence of these skills has been the focus of much research on human children, little is known about ontogenetic patterns shaping spatial cognition in other species. Comparative developmental studies of nonhuman apes can…

Constructing Spatial Meaning: Spatial Affordances in Museum Design

ERIC Educational Resources Information Center

Wineman, Jean D.; Peponis, John

2010-01-01

Informal education in museums is structured through movement in space. This article summarizes a range of research that examines the role of spatial layout in shaping the ways in which visitors explore, engage, and understand museums and museum exhibitions. It is demonstrated that behavior patterns are systematically linked to spatial…

Life expectancy impacts due to heating energy utilization in China: Distribution, relations, and policy implications.

PubMed

Wang, Shaobin; Luo, Kunli

2018-01-01

The relation between life expectancy and energy utilization is of particular concern. Different viewpoints concerned the health impacts of heating policy in China. However, it is still obscure that what kind of heating energy or what pattern of heating methods is the most related with the difference of life expectancies in China. The aim of this paper is to comprehensively investigate the spatial relations between life expectancy at birth (LEB) and different heating energy utilization in China by using spatial autocorrelation models including global spatial autocorrelation, local spatial autocorrelation and hot spot analysis. The results showed that: (1) Most of heating energy exhibit a distinct north-south difference, such as central heating supply, stalks and domestic coal. Whereas spatial distribution of domestic natural gas and electricity exhibited west-east differences. (2) Consumption of central heating, stalks and domestic coal show obvious spatial dependence. Whereas firewood, natural gas and electricity did not show significant spatial autocorrelation. It exhibited an extinct south-north difference of heat supply, stalks and domestic coal which were identified to show significant positive spatial autocorrelation. (3) Central heating, residential boilers and natural gas did not show any significant correlations with LEB. While, the utilization of domestic coal and biomass showed significant negative correlations with LEB, and household electricity shows positive correlations. The utilization of domestic coal in China showed a negative effect on LEB, rather than central heating. To improve the solid fuel stoves and control consumption of domestic coal consumption and other low quality solid fuel is imperative to improve the public health level in China in the future. Copyright © 2017 Elsevier B.V. All rights reserved.

Intelligent agents: adaptation of autonomous bimodal microsystems

NASA Astrophysics Data System (ADS)

Smith, Patrice; Terry, Theodore B.

2014-03-01

Autonomous bimodal microsystems exhibiting survivability behaviors and characteristics are able to adapt dynamically in any given environment. Equipped with a background blending exoskeleton it will have the capability to stealthily detect and observe a self-chosen viewing area while exercising some measurable form of selfpreservation by either flying or crawling away from a potential adversary. The robotic agent in this capacity activates a walk-fly algorithm, which uses a built in multi-sensor processing and navigation subsystem or algorithm for visual guidance and best walk-fly path trajectory to evade capture or annihilation. The research detailed in this paper describes the theoretical walk-fly algorithm, which broadens the scope of spatial and temporal learning, locomotion, and navigational performances based on optical flow signals necessary for flight dynamics and walking stabilities. By observing a fly's travel and avoidance behaviors; and, understanding the reverse bioengineering research efforts of others, we were able to conceptualize an algorithm, which works in conjunction with decisionmaking functions, sensory processing, and sensorimotor integration. Our findings suggest that this highly complex decentralized algorithm promotes inflight or terrain travel mobile stability which is highly suitable for nonaggressive micro platforms supporting search and rescue (SAR), and chemical and explosive detection (CED) purposes; a necessity in turbulent, non-violent structured or unstructured environments.

Absolute and convective instabilities of a film flow down a vertical fiber subjected to a radial electric field

NASA Astrophysics Data System (ADS)

Liu, Rong; Chen, Xue; Ding, Zijing

2018-01-01

We consider the motion of a gravity-driven flow down a vertical fiber subjected to a radial electric field. This flow exhibits rich dynamics including the formation of droplets, or beads, driven by a Rayleigh-Plateau mechanism modified by the presence of gravity as well as the Maxwell stress at the interface. A spatiotemporal stability analysis is performed to investigate the effect of electric field on the absolute-convective instability (AI-CI) characteristics. We performed a numerical simulation on the nonlinear evolution of the film to examine the transition from CI to AI regime. The numerical results are in excellent agreement with the spatiotemporal stability analysis. The blowup behavior of nonlinear simulation predicts the formation of touchdown singularity of the interface due to the effect of electric field. We try to connect the blowup behavior with the AI-CI characteristics. It is found that the singularities mainly occur in the AI regime. The results indicate that the film may have a tendency to form very sharp tips due to the enhancement of the absolute instability induced by the electric field. We perform a theoretical analysis to study the behaviors of the singularities. The results show that there exists a self-similarity between the temporal and spatial distances from the singularities.

Stability of Inhomogeneous Equilibria of Hamiltonian Continuous Media Field Theories

NASA Astrophysics Data System (ADS)

Hagstrom, George

2013-10-01

There are a wide variety of 1 + 1 Hamiltonian continuous media field theories that exhibit phase space pattern formation. In plasma physics, the most famous of these is the Vlasov-Poisson equation, but other examples include the incompressible Euler equation in two-dimensions and the Hamiltonian Mean Field (or XY) model. One of the characteristic phenomenon that occurs in systems described by these equations is the formation of cat's eye patterns in phase space as a result of the nonlinear saturation of instabilities. Corresponding to each of these cat's eyes is a spatially inhomogeneous equilibrium solution of the underlying model, in plasma physics these are called BGK modes, but analogous solutions exist in all of the above systems. Here we analyze the stability of inhomogeneous equilibria in the Hamiltonian Mean Field model and in the Single Wave model, which is an equation that was derived to provide a model of the formation of electron holes in plasmas. We use action angle variables and the properties of elliptic functions to analyze the resulting dispersion relation construct linearly stable inhomogeneous equilibria for in the limit of small numbers of particles and study the behavior of solutions near these equilibria. Work supported by USDOE grant no. DE-FG02-ER53223.

Phase Coupling in Langmuir Wave Packets: Evidence for Four Wave Interactions in Solar Type III Radio Bursts

NASA Technical Reports Server (NTRS)

Thejappa, G.; MacDowall, R. J.; Bergamo, M.

2012-01-01

The four wave interaction process, known as the oscillating two stream instability (OTSI) is considered as one of the mechanisms responsible for stabilizing the electron beams associated with solar type III radio bursts. It has been reported that (1) an intense localized Langmuir wave packet associated with a type III burst contains the spectral characteristics of the OTSI: (a) a resonant peak at the local electron plasma frequency, f(sub pe), (b) a Stokes peak at a frequency slightly lower than f(sub pe), (c) anti-Stokes peak at a frequency slightly higher than f(sub pe), and (d) a low frequency enhancement below a few hundred Hz, (2) the frequencies and wave numbers of these spectral components satisfy the resonance conditions of the OTSI, and (3) the peak intensity of the wave packet is well above the thresholds for the OTSI as well as spatial collapse of envelope solitons. Here, for the first time, applying the trispectral analysis on this wave packet, we show that the tricoherence, which measures the degree of coherent four-wave coupling amongst the observed spectral components exhibits a peak. This provides an additional evidence for the OTSI and related spatial collapse of Langmuir envelope solitons in type III burst sources.

A tale of two seas: contrasting patterns of population structure in the small-spotted catshark across Europe

PubMed Central

Gubili, Chrysoula; Sims, David W.; Veríssimo, Ana; Domenici, Paolo; Ellis, Jim; Grigoriou, Panagiotis; Johnson, Andrew F.; McHugh, Matthew; Neat, Francis; Satta, Andrea; Scarcella, Giuseppe; Serra-Pereira, Bárbara; Soldo, Alen; Genner, Martin J.; Griffiths, Andrew M.

2014-01-01

Elasmobranchs represent important components of marine ecosystems, but they can be vulnerable to overexploitation. This has driven investigations into the population genetic structure of large-bodied pelagic sharks, but relatively little is known of population structure in smaller demersal taxa, which are perhaps more representative of the biodiversity of the group. This study explores spatial population genetic structure of the small-spotted catshark (Scyliorhinus canicula), across European seas. The results show significant genetic differences among most of the Mediterranean sample collections, but no significant structure among Atlantic shelf areas. The data suggest the Mediterranean populations are likely to have persisted in a stable and structured environment during Pleistocene sea-level changes. Conversely, the Northeast Atlantic populations would have experienced major changes in habitat availability during glacial cycles, driving patterns of population reduction and expansion. The data also provide evidence of male-biased dispersal and female philopatry over large spatial scales, implying complex sex-determined differences in the behaviour of elasmobranchs. On the basis of this evidence, we suggest that patterns of connectivity are determined by trends of past habitat stability that provides opportunity for local adaptation in species exhibiting philopatric behaviour, implying that resilience of populations to fisheries and other stressors may differ across the range of species. PMID:26064555

Slope stability radar for monitoring mine walls

NASA Astrophysics Data System (ADS)

Reeves, Bryan; Noon, David A.; Stickley, Glen F.; Longstaff, Dennis

2001-11-01

Determining slope stability in a mining operation is an important task. This is especially true when the mine workings are close to a potentially unstable slope. A common technique to determine slope stability is to monitor the small precursory movements, which occur prior to collapse. The slope stability radar has been developed to remotely scan a rock slope to continuously monitor the spatial deformation of the face. Using differential radar interferometry, the system can detect deformation movements of a rough wall with sub-millimeter accuracy, and with high spatial and temporal resolution. The effects of atmospheric variations and spurious signals can be reduced via signal processing means. The advantage of radar over other monitoring techniques is that it provides full area coverage without the need for mounted reflectors or equipment on the wall. In addition, the radar waves adequately penetrate through rain, dust and smoke to give reliable measurements, twenty-four hours a day. The system has been trialed at three open-cut coal mines in Australia, which demonstrated the potential for real-time monitoring of slope stability during active mining operations.

Temporal acceleration of spatially distributed kinetic Monte Carlo simulations

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chatterjee, Abhijit; Vlachos, Dionisios G.

The computational intensity of kinetic Monte Carlo (KMC) simulation is a major impediment in simulating large length and time scales. In recent work, an approximate method for KMC simulation of spatially uniform systems, termed the binomial {tau}-leap method, was introduced [A. Chatterjee, D.G. Vlachos, M.A. Katsoulakis, Binomial distribution based {tau}-leap accelerated stochastic simulation, J. Chem. Phys. 122 (2005) 024112], where molecular bundles instead of individual processes are executed over coarse-grained time increments. This temporal coarse-graining can lead to significant computational savings but its generalization to spatially lattice KMC simulation has not been realized yet. Here we extend the binomial {tau}-leapmore » method to lattice KMC simulations by combining it with spatially adaptive coarse-graining. Absolute stability and computational speed-up analyses for spatial systems along with simulations provide insights into the conditions where accuracy and substantial acceleration of the new spatio-temporal coarse-graining method are ensured. Model systems demonstrate that the r-time increment criterion of Chatterjee et al. obeys the absolute stability limit for values of r up to near 1.« less

Spatial coherence resonance and spatial pattern transition induced by the decrease of inhibitory effect in a neuronal network

NASA Astrophysics Data System (ADS)

Tao, Ye; Gu, Huaguang; Ding, Xueli

2017-10-01

Spiral waves were observed in the biological experiment on rat brain cortex with the application of carbachol and bicuculline which can block inhibitory coupling from interneurons to pyramidal neurons. To simulate the experimental spiral waves, a two-dimensional neuronal network composed of pyramidal neurons and inhibitory interneurons was built. By decreasing the percentage of active inhibitory interneurons, the random-like spatial patterns change to spiral waves and to random-like spatial patterns or nearly synchronous behaviors. The spiral waves appear at a low percentage of inhibitory interneurons, which matches the experimental condition that inhibitory couplings of the interneurons were blocked. The spiral waves exhibit a higher order or signal-to-noise ratio (SNR) characterized by spatial structure function than both random-like spatial patterns and nearly synchronous behaviors, which shows that changes of the percentage of active inhibitory interneurons can induce spatial coherence resonance-like behaviors. In addition, the relationship between the coherence degree and the spatial structures of the spiral waves is identified. The results not only present a possible and reasonable interpretation to the spiral waves observed in the biological experiment on the brain cortex with disinhibition, but also reveal that the spiral waves exhibit more ordered degree in spatial patterns.

Comparison of spatially and temporally resolved diffuse transillumination measurement systems for extraction of optical properties of scattering media.

PubMed

Ortiz-Rascón, E; Bruce, N C; Garduño-Mejía, J; Carrillo-Torres, R; Hernández-Paredes, J; Álvarez-Ramos, M E

2017-11-20

This paper discusses the main differences between two different methods for determining the optical properties of tissue optical phantoms by fitting the spatial and temporal intensity distribution functions to the diffusion approximation theory. The consistency in the values of the optical properties is verified by changing the width of the recipient containing the turbid medium; as the optical properties are an intrinsic value of the scattering medium, independently of the recipient width, the stability in these values for different widths implies a better measurement system for the acquisition of the optical properties. It is shown that the temporal fitting method presents higher stability than the spatial fitting method; this is probably due to the addition of the time of flight parameter into the diffusion theory.

SPATIAL AGGREGATION IN A FOREST FLOOR INSECT DEPENDS ON SEASONAL CONGREGATION AND SCATTERING EFFECTS OF PREDATORS

EPA Science Inventory

Spatial aggregations arising from gregarious behavior are common in nature and have important implications for population dynamics, community stability, and conservation. However, the translation of aggregation behaviors into emergent properties of populations and communities de...

Development of novel zein-sodium caseinate nanoparticle (ZP)-stabilized emulsion films for improved water barrier properties via emulsion/solvent evaporation.

PubMed

Wang, Li-Juan; Yin, Ye-Chong; Yin, Shou-Wei; Yang, Xiao-Quan; Shi, Wei-Jian; Tang, Chuan-He; Wang, Jin-Mei

2013-11-20

This work attempted to develop novel high barrier zein/SC nanoparticle (ZP)-stabilized emulsion films through microfluidic emulsification (ZPE films) or in combination with solvent (ethyl acetate) evaporation techniques (ZPE-EA films). Some physical properties, including tensile and optical properties, water vapor permeability (WVP), and surface hydrophobicity, as well as the microstructure of ZP-stabilized emulsion films were evaluated and compared with SC emulsion (SCE) films. The emulsion/solvent evaporation approach reduced lipid droplets of ZP-stabilized emulsions, and lipid droplets of ZP-stabilized emulsions were similar to or slightly lower than that of SC emulsions. However, ZP- and SC-stabilized emulsion films exhibited a completely different microstructure, nanoscalar lipid droplets were homogeneously distributed in the ZPE film matrix and interpenetrating protein-oil complex networks occurred within ZPE-EA films, whereas SCE films presented a heterogeneous microstructure. The different stabilization mechanisms against creaming or coalescence during film formation accounted for the preceding discrepancy of the microstructures between ZP-and SC-stabilized emulsion films. Interestingly, ZP-stabilized emulsion films exhibited a better water barrier efficiency, and the WVP values were only 40-50% of SCE films. A schematic representation for the formation of ZP-stabilized emulsion films was proposed to relate the physical performance of the films with their microstructure and to elucidate the possible forming mechanism of the films.

Spatial and Temporal Dynamics of Pacific Oyster Hemolymph Microbiota across Multiple Scales

PubMed Central

Lokmer, Ana; Goedknegt, M. Anouk; Thieltges, David W.; Fiorentino, Dario; Kuenzel, Sven; Baines, John F.; Wegner, K. Mathias

2016-01-01

Unveiling the factors and processes that shape the dynamics of host associated microbial communities (microbiota) under natural conditions is an important part of understanding and predicting an organism's response to a changing environment. The microbiota is shaped by host (i.e., genetic) factors as well as by the biotic and abiotic environment. Studying natural variation of microbial community composition in multiple host genetic backgrounds across spatial as well as temporal scales represents a means to untangle this complex interplay. Here, we combined a spatially-stratified with a longitudinal sampling scheme within differentiated host genetic backgrounds by reciprocally transplanting Pacific oysters between two sites in the Wadden Sea (Sylt and Texel). To further differentiate contingent site from host genetic effects, we repeatedly sampled the same individuals over a summer season to examine structure, diversity and dynamics of individual hemolymph microbiota following experimental removal of resident microbiota by antibiotic treatment. While a large proportion of microbiome variation could be attributed to immediate environmental conditions, we observed persistent effects of antibiotic treatment and translocation suggesting that hemolymph microbial community dynamics is subject to within-microbiome interactions and host population specific factors. In addition, the analysis of spatial variation revealed that the within-site microenvironmental heterogeneity resulted in high small-scale variability, as opposed to large-scale (between-site) stability. Similarly, considerable within-individual temporal variability was in contrast with the overall temporal stability at the site level. Overall, our longitudinal, spatially-stratified sampling design revealed that variation in hemolymph microbiota is strongly influenced by site and immediate environmental conditions, whereas internal microbiome dynamics and oyster-related factors add to their long-term stability. The combination of small and large scale resolution of spatial and temporal observations therefore represents a crucial but underused tool to study host-associated microbiome dynamics. PMID:27630625

Automated selection of stabilizing mutations in designed and natural proteins.

PubMed

Borgo, Benjamin; Havranek, James J

2012-01-31

The ability to engineer novel protein folds, conformations, and enzymatic activities offers enormous potential for the development of new protein therapeutics and biocatalysts. However, many de novo and redesigned proteins exhibit poor hydrophobic packing in their predicted structures, leading to instability or insolubility. The general utility of rational, structure-based design would greatly benefit from an improved ability to generate well-packed conformations. Here we present an automated protocol within the RosettaDesign framework that can identify and improve poorly packed protein cores by selecting a series of stabilizing point mutations. We apply our method to previously characterized designed proteins that exhibited a decrease in stability after a full computational redesign. We further demonstrate the ability of our method to improve the thermostability of a well-behaved native protein. In each instance, biophysical characterization reveals that we were able to stabilize the original proteins against chemical and thermal denaturation. We believe our method will be a valuable tool for both improving upon designed proteins and conferring increased stability upon native proteins.

Automated selection of stabilizing mutations in designed and natural proteins

PubMed Central

Borgo, Benjamin; Havranek, James J.

2012-01-01

The ability to engineer novel protein folds, conformations, and enzymatic activities offers enormous potential for the development of new protein therapeutics and biocatalysts. However, many de novo and redesigned proteins exhibit poor hydrophobic packing in their predicted structures, leading to instability or insolubility. The general utility of rational, structure-based design would greatly benefit from an improved ability to generate well-packed conformations. Here we present an automated protocol within the RosettaDesign framework that can identify and improve poorly packed protein cores by selecting a series of stabilizing point mutations. We apply our method to previously characterized designed proteins that exhibited a decrease in stability after a full computational redesign. We further demonstrate the ability of our method to improve the thermostability of a well-behaved native protein. In each instance, biophysical characterization reveals that we were able to stabilize the original proteins against chemical and thermal denaturation. We believe our method will be a valuable tool for both improving upon designed proteins and conferring increased stability upon native proteins. PMID:22307603

Spatial and temporal variability of throughfall and soil moisture in a deciduous forest in the low mountain ranges (Hesse, Germany)

NASA Astrophysics Data System (ADS)

Chifflard, Peter; Weishaupt, Philipp; Reiss, Martin

2017-04-01

Spatial and temporal patterns of throughfall can affect the heterogeneity of ecological, biogeochemical and hydrological processes at a forest floor and further the underlying soil. Previous research suggests different factors controlling the spatial and temporal patterns of throughfall, but most studies focus on coniferous forest, where the vegetation coverage is more or less constant over time. In deciduous forests the leaf area index varies due to the leaf fall in autumn which implicates a specific spatial and temporal variability of throughfall and furthermore of the soil moisture. Therefore, in the present study, the measurements of throughfall and soil moisture in a deciduous forest in the low mountain ranges focused especially on the period of leaf fall. The aims of this study were: 1) to detect the spatial and temporal variability of both the throughfall and the soil moisture, 2) to examine the temporal stability of the spatial patterns of the throughfall and soil moisture and 3) relate the soil moisture patterns to the throughfall patterns and further to the canopy characteristics. The study was carried out in a small catchment on middle Hesse (Germany) which is covered by beech forest. Annual mean air temperature is 9.4°C (48.9˚F) and annual mean precipitation is 650 mm. Base materials for soil genesis is greywacke and clay shale from Devonian deposits. The soil type at the study plot is a shallow cambisol. The study plot covers an area of about 150 m2 where 77 throughfall samplers where installed. The throughfall and the soil moisture (FDR-method, 20 cm depth) was measured immediately after every rainfall event at the 77 measurement points. During the period of October to December 2015 altogether 7 events were investigated. The geostatistical method kriging was used to interpolate between the measurements points to visualize the spatial patterns of each investigated parameter. Time-stability-plots were applied to examine temporal scatters of each investigated parameter. The spearmen and pearson correlation coefficients were applied to detect the relationship between the different investigated parameters. First results show that the spatial variability of throughfall decreases if the total amount of the throughfall increases. The soil moisture shows a similar behavior. It`s spatial variability decreases if higher soil moisture values were measured. Concerning the temporal stability of throughfall it can be shown that it is very high during the leaf-free period, although the rainfall events have different total througfall amounts. The soil moisture patterns consists of a low temporal stability and additionally only during one event a significant correlations between throughfall and soil moisture patterns exists. This implies that other factors than the throughfall patterns control the spatial patterns of soil moisture.

Microstructure and Mechanical Properties of Ultrafine-Grained Al-6061 Prepared Using Intermittent Ultrasonic-Assisted Equal-Channel Angular Pressing

NASA Astrophysics Data System (ADS)

Lu, Jianxun; Wu, Xiaoyu; Wu, Zhaozhi; Liu, Zhiyuan; Guo, Dengji; Lou, Yan; Ruan, Shuangchen

2017-10-01

Equal-channel angular pressing (ECAP) is an efficient technique to achieve grain refinement in a wide range of materials. However, the extrusion process requires an excessive extrusion force, the microstructure of ECAPed specimens scatters heterogeneously because of considerable fragmentation of the structure and strain heterogeneity, and the resultant ultrafine grains exhibit poor thermal stability. The intermittent ultrasonic-assisted ECAP (IU-ECAP) approach was proposed to address these issues. In this work, ECAP and IU-ECAP were applied to produce ultrafine-grained Al-6061 alloys, and the differences in their mechanical properties, microstructural characteristics, and thermal stability were investigated. Mechanical testing demonstrated that the necessary extrusion force for IU-ECAP was significantly reduced; even more, the microhardness and ultimate tensile strength were strengthened. In addition, the IU-ECAPed Al alloy exhibited a smaller grain size with a more homogeneous microstructure. X-ray diffraction analysis indicated that the intensities of the textures were weakened using IU-ECAP, and a more homogeneous microstructure and larger dislocation densities were obtained. Investigation of the thermal stability revealed that the ultrafine-grained materials produced using IU-ECAP recrystallized at higher temperature or after longer time; the materials thus exhibited improved thermal stability.

Synthesis and Phase Stability of Scandia, Gadolinia, and Ytterbia Co-doped Zirconia for Thermal Barrier Coating Application

NASA Astrophysics Data System (ADS)

Li, Qi-Lian; Cui, Xiang-Zhong; Li, Shu-Qing; Yang, Wei-Hua; Wang, Chun; Cao, Qian

2015-01-01

Scandia, gadolinia, and ytterbia co-doped zirconia (SGYZ) ceramic powder was synthesized by chemical co-precipitation and calcination processes for application in thermal barrier coatings to promote the durability of gas turbines. The ceramic powder was agglomerated and sintered at 1150 °C for 2 h, and the powder exhibited good flowability and apparent density to be suitable for plasma spraying process. The microstructure, morphology and phase stability of the powder and plasma-sprayed SGYZ coatings were analyzed by means of scanning electron microscope and x-ray diffraction. Thermal conductivity of plasma-sprayed SGYZ coatings was measured. The results indicated that the SGYZ ceramic powder and the coating exhibit excellent stability to retain single non-transformable tetragonal zirconia even after high temperature (1400 °C) exposure for 500 h and do not undergo a tetragonal-to-monoclinic phase transition upon cooling. Furthermore, the plasma-sprayed SGYZ coating also exhibits lower thermal conductivity than yttria stabilized zirconia coating currently used in gas turbine engine industry. SGYZ can be explored as a candidate material of ultra-high temperature thermal barrier coating for advanced gas turbine engines.

Studies in nonlinear problems of energy. Progress report, October 1, 1993--September 30, 1994

DOE Office of Scientific and Technical Information (OSTI.GOV)

Matkowsky, B.J.

1994-09-01

The authors concentrate on modeling, analysis and large scale scientific computation of combustion and flame propagation phenomena, with emphasis on the transition from laminar to turbulent combustion. In the transition process a flame passed through a stages exhibiting increasingly complex spatial and temporal patterns which serve as signatures identifying each stage. Often the transitions arise via bifurcation. The authors investigate nonlinear dynamics, bifurcation and pattern formation in the successive stage of transition. They describe the stability of combustion waves, and transitions to combustion waves exhibiting progressively higher degrees of spatio-temporal complexity. One aspect of this research program is the systematicmore » derivation of appropriate, approximate models from the original models governing combustion. The approximate models are then analyzed. The authors are particularly interested in understanding the basic mechanisms affecting combustion, which is a prerequisite to effective control of the process. They are interested in determining the effects of varying various control parameters, such as Nusselt number, Lewis number, heat release, activation energy, Damkohler number, Reynolds number, Prandtl number, Peclet number, etc. The authors have also considered a number of problems in self-propagating high-temperature synthesis (SHS), in which combustion waves are employed to synthesize advanced materials. Efforts are directed toward understanding fundamental mechanisms. 167 refs.« less

Endosymbiotic flexibility associates with environmental sensitivity in scleractinian corals.

PubMed

Putnam, Hollie M; Stat, Michael; Pochon, Xavier; Gates, Ruth D

2012-11-07

Flexibility in biological systems is seen as an important driver of macro-ecosystem function and stability. Spatially constrained endosymbiotic settings, however, are less studied, although environmental thresholds of symbiotic corals are linked to the function of their endosymbiotic dinoflagellate communities. Symbiotic flexibility is a hypothesized mechanism that corals may exploit to adapt to climate change. This study explores the flexibility of the coral-Symbiodinium symbiosis through quantification of Symbiodinium ITS2 sequence assemblages in a range of coral species and genera. Sequence assemblages are expressed as an index of flexibility incorporating phylogenetic divergence and relative abundance of Symbiodinium sequences recovered from the host. This comparative analysis reveals profound differences in the flexibility of corals for Symbiodinium, thereby classifying corals as generalists or specifists. Generalists such as Acropora and Pocillopora exhibit high intra- and inter-species flexibility in their Symbiodinium assemblages and are some of the most environmentally sensitive corals. Conversely, specifists such as massive Porites colonies exhibit low flexibility, harbour taxonomically narrow Symbiodinium assemblages, and are environmentally resistant corals. Collectively, these findings challenge the paradigm that symbiotic flexibility enhances holobiont resilience. This underscores the need for a deeper examination of the extent and duration of the functional benefits associated with endosymbiotic diversity and flexibility under environmental stress.

Structure and Stability of One-Dimensional Detonations in Ethylene-Air Mixtures

NASA Technical Reports Server (NTRS)

Yungster, S.; Radhakrishnan, K.; Perkins, High D. (Technical Monitor)

2003-01-01

The propagation of one-dimensional detonations in ethylene-air mixtures is investigated numerically by solving the one-dimensional Euler equations with detailed finite-rate chemistry. The numerical method is based on a second-order spatially accurate total-variation-diminishing scheme and a point implicit, first-order-accurate, time marching algorithm. The ethylene-air combustion is modeled with a 20-species, 36-step reaction mechanism. A multi-level, dynamically adaptive grid is utilized, in order to resolve the structure of the detonation. Parametric studies over an equivalence ratio range of 0.5 less than phi less than 3 for different initial pressures and degrees of detonation overdrive demonstrate that the detonation is unstable for low degrees of overdrive, but the dynamics of wave propagation varies with fuel-air equivalence ratio. For equivalence ratios less than approximately 1.2 the detonation exhibits a short-period oscillatory mode, characterized by high-frequency, low-amplitude waves. Richer mixtures (phi greater than 1.2) exhibit a low-frequency mode that includes large fluctuations in the detonation wave speed; that is, a galloping propagation mode is established. At high degrees of overdrive, stable detonation wave propagation is obtained. A modified McVey-Toong short-period wave-interaction theory is in excellent agreement with the numerical simulations.

Engineering of functional, perfusable 3D microvascular networks on a chip.

PubMed

Kim, Sudong; Lee, Hyunjae; Chung, Minhwan; Jeon, Noo Li

2013-04-21

Generating perfusable 3D microvessels in vitro is an important goal for tissue engineering, as well as for reliable modelling of blood vessel function. To date, in vitro blood vessel models have not been able to accurately reproduce the dynamics and responses of endothelial cells to grow perfusable and functional 3D vascular networks. Here we describe a microfluidic-based platform whereby we model natural cellular programs found during normal development and angiogenesis to form perfusable networks of intact 3D microvessels as well as tumor vasculatures based on the spatially controlled co-culture of endothelial cells with stromal fibroblasts, pericytes or cancer cells. The microvessels possess the characteristic morphological and biochemical markers of in vivo blood vessels, and exhibit strong barrier function and long-term stability. An open, unobstructed microvasculature allows the delivery of nutrients, chemical compounds, biomolecules and cell suspensions, as well as flow-induced mechanical stimuli into the luminal space of the endothelium, and exhibits faithful responses to physiological shear stress as demonstrated by cytoskeleton rearrangement and increased nitric oxide synthesis. This simple and versatile platform provides a wide range of applications in vascular physiology studies as well as in developing vascularized organ-on-a-chip and human disease models for pharmaceutical screening.

Traffic flow theory and chaotic behavior

DOT National Transportation Integrated Search

1989-03-01

Many commonly occurring natural systems are modeled with mathematical experessions and exhibit a certain stability. The inherent stability of these equations allows them to serve as the basis for engineering predictions. More complex models, such as ...

Combustion stability with baffles, absorbers and velocity sensitive combustion. [liquid propellant rocket combustors

NASA Technical Reports Server (NTRS)

Mitchell, C. E.

1980-01-01

Analytical and computational techniques were developed to predict the stability behavior of liquid propellant rocket combustors using damping devices such as acoustic liners, slot absorbers, and injector face baffles. Models were developed to determine the frequency and decay rate of combustor oscillations, the spatial and temporal pressure waveforms, and the stability limits in terms of combustion response model parameters.

Stabilization of the wheel running phenotype in mice.

PubMed

Bowen, Robert S; Cates, Brittany E; Combs, Eric B; Dillard, Bryce M; Epting, Jessica T; Foster, Brittany R; Patterson, Shawnee V; Spivey, Thomas P

2016-03-01

Increased physical activity is well known to improve health and wellness by modifying the risks for many chronic diseases. Rodent wheel running behavior is a beneficial surrogate model to evaluate the biology of daily physical activity in humans. Upon initial exposure to a running wheel, individual mice differentially respond to the experience, which confounds the normal activity patterns exhibited in this otherwise repeatable phenotype. To promote phenotypic stability, a minimum seven-day (or greater) acclimation period is utilized. Although phenotypic stabilization is achieved during this 7-day period, data to support acclimation periods of this length are not currently available in the literature. The purpose of this project is to evaluate the wheel running response in C57BL/6j mice immediately following exposure to a running wheel. Twenty-eight male and thirty female C57BL/6j mice (Jackson Laboratory, Bar Harbor, ME) were acquired at eight weeks of age and were housed individually with free access to running wheels. Wheel running distance (km), duration (min), and speed (m∙min(-1)) were measured daily for fourteen days following initial housing. One-way ANOVAs were used to evaluate day-to-day differences in each wheel running character. Limits of agreement and mean difference statistics were calculated between days 1-13 (acclimating) and day 14 (acclimated) to assess day-to-day agreement between each parameter. Wheel running distance (males: F=5.653, p=2.14 × 10(-9); females: F=8.217, p=1.20 × 10(-14)), duration (males: F=2.613, p=0.001; females: F=4.529, p=3.28 × 10(-7)), and speed (males: F=7.803, p=1.22 × 10(-13); females: F=13.140, p=2.00 × 10(-16)) exhibited day-to-day differences. Tukey's HSD post-hoc testing indicated differences between early (males: days 1-3; females: days 1-6) and later (males: days >3; females: days >6) wheel running periods in distance and speed. Duration only exhibited an anomalous difference between wheel running on day 13 and wheel running on days 1 through 4 in males. In females, duration exhibited anomalous differences due to abnormally depressed wheel running on day 6 and abnormally elevated wheel running on day 14. Limits of agreement and mean difference statistics indicated stable phenotypic variability with an up-trending daily mean for distance and speed that stabilized within the first three days in males and within eight days in females. Duration exhibited stable variability after nine days in males and after seven days in females. Although it is common practice to allow a prolonged (≥ seven day) acclimation period prior to recording wheel running data, the current study suggests that phenotypic stabilization of all three indices is achieved at different times with distance and speed exhibiting stability by day three in males and day eight in females. Duration exhibits stability by day nine in males and day seven in females. Copyright © 2015 Elsevier Inc. All rights reserved.

Finding a Place To Stand: Negotiating the Spatial Configuration of the Networked Computer Classroom.

ERIC Educational Resources Information Center

Kent-Drury, Roxanne

1998-01-01

Theorizes the spatial dynamics of both traditional and Internet-networked classrooms to reveal that both exhibit indeterminate spatial characteristics, but that network connectivity renders this indeterminacy visible. Argues that networked classrooms need not be disorienting, if students recreate a center by designing a class Web site, creating…

Tailoring Magnetic Skyrmions by Geometric Confinement of Magnetic Structures

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhang, Steven S.-L.; Phatak, C.; Petford-Long, A K

Nanoscale magnetic skyrmions have interesting static and transport properties that make them candidates for future spintronic devices. Control and manipulation of the size and behavior of skyrmions is thus of crucial importance. Here, using a Ginzburg-Landau approach, we show theoretically that skyrmions and skyrmion lattices can be stabilized by a spatial modulation of the uniaxial magnetic anisotropy in a thin film of a centro-symmetric ferromagnet. Remarkably, the skyrmion size is determined by the ratio of the exchange length and the period of the spatial modulation of the anisotropy, at variance with conventional skyrmions stabilized by dipolar and Dzyaloshinskii–Moriya interactions.

Tailoring Magnetic Skyrmions by Geometric Confinement of Magnetic Structures

DOE PAGES

Zhang, Steven S.-L.; Phatak, C.; Petford-Long, A K; ...

2017-12-12

Nanoscale magnetic skyrmions have interesting static and transport properties that make them candidates for future spintronic devices. Control and manipulation of the size and behavior of skyrmions is thus of crucial importance. Here, using a Ginzburg-Landau approach, we show theoretically that skyrmions and skyrmion lattices can be stabilized by a spatial modulation of the uniaxial magnetic anisotropy in a thin film of a centro-symmetric ferromagnet. Remarkably, the skyrmion size is determined by the ratio of the exchange length and the period of the spatial modulation of the anisotropy, at variance with conventional skyrmions stabilized by dipolar and Dzyaloshinskii–Moriya interactions.

Stability and Hopf Bifurcation in a Reaction-Diffusion Model with Chemotaxis and Nonlocal Delay Effect

NASA Astrophysics Data System (ADS)

Li, Dong; Guo, Shangjiang

Chemotaxis is an observed phenomenon in which a biological individual moves preferentially toward a relatively high concentration, which is contrary to the process of natural diffusion. In this paper, we study a reaction-diffusion model with chemotaxis and nonlocal delay effect under Dirichlet boundary condition by using Lyapunov-Schmidt reduction and the implicit function theorem. The existence, multiplicity, stability and Hopf bifurcation of spatially nonhomogeneous steady state solutions are investigated. Moreover, our results are illustrated by an application to the model with a logistic source, homogeneous kernel and one-dimensional spatial domain.

Postural stability changes in the elderly with cataract simulation and refractive blur.

PubMed

Anand, Vijay; Buckley, John G; Scally, Andy; Elliott, David B

2003-11-01

To determine the influence of cataractous and refractive blur on postural stability and limb-load asymmetry (LLA) and to establish how postural stability changes with the spatial frequency and contrast of the visual stimulus. Thirteen elderly subjects (mean age, 70.76 +/- 4.14 [SD] years) with no history of falls and normal vision were recruited. Postural stability was determined as the root mean square [RMS] of the center of pressure (COP) signal in the anterior-posterior (A-P) and medial-lateral directions and LLA was determined as the ratio of the average body weight placed on the more-loaded limb to the less-loaded limb, recorded during a 30-second period. Data were collected under normal standing conditions and with somatosensory system input disrupted. Measurements were repeated with four visual targets with high (8 cyc/deg) or low (2 cyc/deg) spatial frequency and high (Weber contrast, approximately 95%) or low (Weber contrast, approximately 25%) contrast. Postural stability was measured under conditions of binocular refractive blur of 0, 1, 2, 4, and 8 D and with cataract simulation. The data were analyzed in a population-averaged linear model. The cataract simulation caused significant increases in postural instability equivalent to that caused by 8-D blur conditions, and its effect was greater when the input from the somatosensory system was disrupted. High spatial frequency targets increased postural instability. Refractive blur, cataract simulation, or eye closure had no effect on LLA. Findings indicate that cataractous and refractive blur increase postural instability, and show why the elderly, many of whom have poor vision along with musculoskeletal and central nervous system degeneration, are at greater risk of falling. Findings also highlight that changes in contrast sensitivity rather than resolution changes are responsible for increasing postural instability. Providing low spatial frequency information in certain environments may be useful in maintaining postural stability. Correcting visual impairment caused by uncorrected refractive error and cataracts could be a useful intervention strategy to help prevent falls and fall-related injuries in the elderly.

Spatial and temporal stability of temperature in the first-level basins of China during 1951-2013

NASA Astrophysics Data System (ADS)

Cheng, Yuting; Li, Peng; Xu, Guoce; Li, Zhanbin; Cheng, Shengdong; Wang, Bin; Zhao, Binhua

2018-05-01

In recent years, global warming has attracted great attention around the world. Temperature change is not only involved in global climate change but also closely linked to economic development, the ecological environment, and agricultural production. In this study, based on temperature data recorded by 756 meteorological stations in China during 1951-2013, the spatial and temporal stability characteristics of annual temperature in China and its first-level basins were investigated using the rank correlation coefficient method, the relative difference method, rescaled range (R/S) analysis, and wavelet transforms. The results showed that during 1951-2013, the spatial variation of annual temperature belonged to moderate variability in the national level. Among the first-level basins, the largest variation coefficient was 114% in the Songhuajiang basin and the smallest variation coefficient was 10% in the Huaihe basin. During 1951-2013, the spatial distribution pattern of annual temperature presented extremely strong spatial and temporal stability characteristics in the national level. The variation range of Spearman's rank correlation coefficient was 0.97-0.99, and the spatial distribution pattern of annual temperature showed an increasing trend. In the national level, the Liaohe basin, the rivers in the southwestern region, the Haihe basin, the Yellow River basin, the Yangtze River basin, the Huaihe basin, the rivers in the southeastern region, and the Pearl River basin all had representative meteorological stations for annual temperature. In the Songhuajiang basin and the rivers in the northwestern region, there was no representative meteorological station. R/S analysis, the Mann-Kendall test, and the Morlet wavelet analysis of annual temperature showed that the best representative meteorological station could reflect the variation trend and the main periodic changes of annual temperature in the region. Therefore, strong temporal stability characteristics exist for annual temperature in China and its first-level basins. It was therefore feasible to estimate the annual average temperature by the annual temperature recorded by the representative meteorological station in the region. Moreover, it was of great significance to assess average temperature changes quickly and forecast future change tendencies in the region.

On the axisymmetric stability of heated supersonic round jets

PubMed Central

2016-01-01

We perform an inviscid, spatial stability analysis of supersonic, heated round jets with the mean properties assumed uniform on either side of the jet shear layer, modelled here via a cylindrical vortex sheet. Apart from the hydrodynamic Kelvin–Helmholtz (K–H) wave, the spatial growth rates of the acoustically coupled supersonic and subsonic instability waves are computed for axisymmetric conditions (m=0) to analyse their role on the jet stability, under increased heating and compressibility. With the ambient stationary, supersonic instability waves may exist for any jet Mach number Mj≥2, whereas the subsonic instability waves, in addition, require the core-to-ambient flow temperature ratio Tj/To>1. We show, for moderately heated jets at Tj/To>2, the acoustically coupled instability modes, once cut on, to govern the overall jet stability with the K–H wave having disappeared into the cluster of acoustic modes. Sufficiently high heating makes the subsonic modes dominate the jet near-field dynamics, whereas the supersonic instability modes form the primary Mach radiation at far field. PMID:27274691

Beyond the plot: technology extrapolation domains for scaling out agronomic science

NASA Astrophysics Data System (ADS)

Rattalino Edreira, Juan I.; Cassman, Kenneth G.; Hochman, Zvi; van Ittersum, Martin K.; van Bussel, Lenny; Claessens, Lieven; Grassini, Patricio

2018-05-01

Ensuring an adequate food supply in systems that protect environmental quality and conserve natural resources requires productive and resource-efficient cropping systems on existing farmland. Meeting this challenge will be difficult without a robust spatial framework that facilitates rapid evaluation and scaling-out of currently available and emerging technologies. Here we develop a global spatial framework to delineate ‘technology extrapolation domains’ based on key climate and soil factors that govern crop yields and yield stability in rainfed crop production. The proposed framework adequately represents the spatial pattern of crop yields and stability when evaluated over the data-rich US Corn Belt. It also facilitates evaluation of cropping system performance across continents, which can improve efficiency of agricultural research that seeks to intensify production on existing farmland. Populating this biophysical spatial framework with appropriate socio-economic attributes provides the potential to amplify the return on investments in agricultural research and development by improving the effectiveness of research prioritization and impact assessment.

Modeling the Spatial Dynamics of Regional Land Use: The CLUE-S Model

NASA Astrophysics Data System (ADS)

Verburg, Peter H.; Soepboer, Welmoed; Veldkamp, A.; Limpiada, Ramil; Espaldon, Victoria; Mastura, Sharifah S. A.

2002-09-01

Land-use change models are important tools for integrated environmental management. Through scenario analysis they can help to identify near-future critical locations in the face of environmental change. A dynamic, spatially explicit, land-use change model is presented for the regional scale: CLUE-S. The model is specifically developed for the analysis of land use in small regions (e.g., a watershed or province) at a fine spatial resolution. The model structure is based on systems theory to allow the integrated analysis of land-use change in relation to socio-economic and biophysical driving factors. The model explicitly addresses the hierarchical organization of land use systems, spatial connectivity between locations and stability. Stability is incorporated by a set of variables that define the relative elasticity of the actual land-use type to conversion. The user can specify these settings based on expert knowledge or survey data. Two applications of the model in the Philippines and Malaysia are used to illustrate the functioning of the model and its validation.

Biodiversity and ecosystem stability across scales in metacommunities.

PubMed

Wang, Shaopeng; Loreau, Michel

2016-05-01

Although diversity-stability relationships have been extensively studied in local ecosystems, the global biodiversity crisis calls for an improved understanding of these relationships in a spatial context. Here, we use a dynamical model of competitive metacommunities to study the relationships between species diversity and ecosystem variability across scales. We derive analytic relationships under a limiting case; these results are extended to more general cases with numerical simulations. Our model shows that, while alpha diversity decreases local ecosystem variability, beta diversity generally contributes to increasing spatial asynchrony among local ecosystems. Consequently, both alpha and beta diversity provide stabilising effects for regional ecosystems, through local and spatial insurance effects respectively. We further show that at the regional scale, the stabilising effect of biodiversity increases as spatial environmental correlation increases. Our findings have important implications for understanding the interactive effects of global environmental changes (e.g. environmental homogenisation) and biodiversity loss on ecosystem sustainability at large scales. © 2016 John Wiley & Sons Ltd/CNRS.

Spatial filter with volume gratings for high-peak-power multistage laser amplifiers

NASA Astrophysics Data System (ADS)

Tan, Yi-zhou; Yang, Yi-sheng; Zheng, Guang-wei; Shen, Ben-jian; Pan, Heng-yue; Liu, Li

2010-08-01

The regular spatial filters comprised of lens and pinhole are essential component in high power laser systems, such as lasers for inertial confinement fusion, nonlinear optical technology and directed-energy weapon. On the other hand the pinhole is treated as a bottleneck of high power laser due to harmful plasma created by the focusing beam. In this paper we present a spatial filter based on angular selectivity of Bragg diffraction grating to avoid the harmful focusing effect in the traditional pinhole filter. A spatial filter consisted of volume phase gratings in two-pass amplifier cavity were reported. Two-dimensional filter was proposed by using single Pi-phase-shifted Bragg grating, numerical simulation results shown that its angular spectrum bandwidth can be less than 160urad. The angular selectivity of photo-thermorefractive glass and RUGATE film filters, construction stability, thermal stability and the effects of misalignments of gratings on the diffraction efficiencies under high-pulse-energy laser operating condition are discussed.

Modeling the spatial dynamics of regional land use: the CLUE-S model.

PubMed

Verburg, Peter H; Soepboer, Welmoed; Veldkamp, A; Limpiada, Ramil; Espaldon, Victoria; Mastura, Sharifah S A

2002-09-01

Land-use change models are important tools for integrated environmental management. Through scenario analysis they can help to identify near-future critical locations in the face of environmental change. A dynamic, spatially explicit, land-use change model is presented for the regional scale: CLUE-S. The model is specifically developed for the analysis of land use in small regions (e.g., a watershed or province) at a fine spatial resolution. The model structure is based on systems theory to allow the integrated analysis of land-use change in relation to socio-economic and biophysical driving factors. The model explicitly addresses the hierarchical organization of land use systems, spatial connectivity between locations and stability. Stability is incorporated by a set of variables that define the relative elasticity of the actual land-use type to conversion. The user can specify these settings based on expert knowledge or survey data. Two applications of the model in the Philippines and Malaysia are used to illustrate the functioning of the model and its validation.

Imaging magnetisation dynamics in nano-contact spin-torque vortex oscillators exhibiting gyrotropic mode splitting

NASA Astrophysics Data System (ADS)

Keatley, Paul Steven; Redjai Sani, Sohrab; Hrkac, Gino; Majid Mohseni, Seyed; Dürrenfeld, Philipp; Åkerman, Johan; Hicken, Robert James

2017-04-01

Nano-contact spin-torque vortex oscillators (STVOs) are anticipated to find application as nanoscale sources of microwave emission in future technological applications. Presently the output power and phase stability of individual STVOs are not competitive with existing oscillator technologies. Synchronisation of multiple nano-contact STVOs via magnetisation dynamics has been proposed to enhance the microwave emission. The control of device-to-device variations, such as mode splitting of the microwave emission, is essential if multiple STVOs are to be successfully synchronised. In this work a combination of electrical measurements and time-resolved scanning Kerr microscopy (TRSKM) was used to demonstrate how mode splitting in the microwave emission of STVOs was related to the magnetisation dynamics that are generated. The free-running STVO response to a DC current only was used to identify devices and bias magnetic field configurations for which single and multiple modes of microwave emission were observed. Stroboscopic Kerr images were acquired by injecting a small amplitude RF current to phase lock the free-running STVO response. The images showed that the magnetisation dynamics of a multimode device with moderate splitting could be controlled by the injected RF current so that they exhibit similar spatial character to that of a single mode. Significant splitting was found to result from a complicated equilibrium magnetic state that was observed in Kerr images as irregular spatial characteristics of the magnetisation dynamics. Such dynamics were observed far from the nano-contact and so their presence cannot be detected in electrical measurements. This work demonstrates that TRSKM is a powerful tool for the direct observation of the magnetisation dynamics generated by STVOs that exhibit complicated microwave emission. Characterisation of such dynamics outside the nano-contact perimeter permits a deeper insight into the requirements for optimal phase-locking of multiple STVOs that share common magnetic layers. , which features invited work from the best early-career researchers working within the scope of J. Phys. D. This project is part of the Journal of Physics series' 50th anniversary celebrations in 2017. Paul Keatley was selected by the Editorial Board of J. Phys. D as an Emerging Leader.

Flight evaluation of the transonic stability and control characteristics of an airplane incorporating a supercritical wing

NASA Technical Reports Server (NTRS)

Matheny, N. W.; Gatlin, D. H.

1978-01-01

A TF-8A airplane was equipped with a transport type supercritical wing and fuselage fairings to evaluate predicted performance improvements for cruise at transonic speeds. A comparison of aerodynamic derivatives extracted from flight and wind tunnel data showed that static longitudinal stability, effective dihedral, and aileron effectiveness, were higher than predicted. The static directional stability derivative was slower than predicted. The airplane's handling qualities were acceptable with the stability augmentation system on. The unaugmented airplane exhibited some adverse lateral directional characteristics that involved low Dutch roll damping and low roll control power at high angles of attack and roll control power that was greater than satisfactory for transport aircraft at cruise conditions. Longitudinally, the aircraft exhibited a mild pitchup tendency. Leading edge vortex generators delayed the onset of flow separation, moving the pitchup point to a higher lift coefficient and reducing its severity.

Three-dimensional modelling of slope stability using the Local Factor of Safety concept

NASA Astrophysics Data System (ADS)

Moradi, Shirin; Huisman, Sander; Beck, Martin; Vereecken, Harry; Class, Holger

2017-04-01

Slope stability is governed by coupled hydrological and mechanical processes. The slope stability depends on the effective stress, which in turn depends on the weight of the soil and the matrix potential. Therefore, changes in water content and matrix potential associated with infiltration will affect slope stability. Most available models describing these coupled hydro-mechanical processes either rely on a one- or two-dimensional representation of hydrological and mechanical properties and processes, which obviously is a strong simplification in many applications. Therefore, the aim of this work is to develop a three-dimensional hydro-mechanical model that is able to capture the effect of spatial and temporal variability of both mechanical and hydrological parameters on slope stability. For this, we rely on DuMux, which is a free and open-source simulator for flow and transport processes in porous media that facilitates coupling of different model approaches and offers flexibility for model development. We use the Richards equation to model unsaturated water flow. The simulated water content and matrix potential distribution is used to calculate the effective stress. We only consider linear elasticity and solve for statically admissible fields of stress and displacement without invoking failure or the redistribution of post-failure stress or displacement. The Local Factor of Safety concept is used to evaluate slope stability in order to overcome some of the main limitations of commonly used methods based on limit equilibrium considerations. In a first step, we compared our model implementation with a 2D benchmark model that was implemented in COMSOL Multiphysics. In a second step, we present in-silico experiments with the newly developed 3D model to show the effect of slope morphology, spatial variability in hydraulic and mechanical material properties, and spatially variable soil depth on simulated slope stability. It is expected that this improved physically-based three-dimensional hydro-mechanical model is able to provide more reliable slope instability predictions in more complex situations.

Optimal exploitation of spatially distributed trophic resources and population stability

USGS Publications Warehouse

Basset, A.; Fedele, M.; DeAngelis, D.L.

2002-01-01

The relationships between optimal foraging of individuals and population stability are addressed by testing, with a spatially explicit model, the effect of patch departure behaviour on individual energetics and population stability. A factorial experimental design was used to analyse the relevance of the behavioural factor in relation to three factors that are known to affect individual energetics; i.e. resource growth rate (RGR), assimilation efficiency (AE), and body size of individuals. The factorial combination of these factors produced 432 cases, and 1000 replicate simulations were run for each case. Net energy intake rates of the modelled consumers increased with increasing RGR, consumer AE, and consumer body size, as expected. Moreover, through their patch departure behaviour, by selecting the resource level at which they departed from the patch, individuals managed to substantially increase their net energy intake rates. Population stability was also affected by the behavioural factors and by the other factors, but with highly non-linear responses. Whenever resources were limiting for the consumers because of low RGR, large individual body size or low AE, population density at the equilibrium was directly related to the patch departure behaviour; on the other hand, optimal patch departure behaviour, which maximised the net energy intake at the individual level, had a negative influence on population stability whenever resource availability was high for the consumers. The consumer growth rate (r) and numerical dynamics, as well as the spatial and temporal fluctuations of resource density, which were the proximate causes of population stability or instability, were affected by the behavioural factor as strongly or even more strongly than by the others factors considered here. Therefore, patch departure behaviour can act as a feedback control of individual energetics, allowing consumers to optimise a potential trade-off between short-term individual fitness and long-term population stability. ?? 2002 Elsevier Science B.V. All rights reserved.

Bimetal–Organic Framework Self-Adjusted Synthesis of Support-Free Nonprecious Electrocatalysts for Efficient Oxygen Reduction

DOE PAGES

You, Bo; Jiang, Nan; Sheng, Meili; ...

2015-10-22

The development of low-cost catalysts with oxygen reduction reaction (ORR) activity superior to that of Pt for fuel cells is highly desirable but remains challenging. Herein, we report a bimetal-organic framework (bi-MOF) self-adjusted synthesis of support-free porous Co-N-C nanopolyhedron electrocatalysts by pyrolysis of a Zn/Co bi-MOF without any post-treatments. The presence of initial Zn forms a spatial isolation of Co that suppresses its sintering during pyrolysis, and Zn evaporation also promotes the surface area of the resultant catalysts. The composition, morphology, and hence ORR activity of Co-N-C could be tuned by the Zn/Co ratio. The optimal Co-N-C exhibited remarkable ORRmore » activity with a half-wave potential of 0.871 V versus the reversible hydrogen electrode (RHE) (30 mV more positive than that of commercial 20 wt % Pt/C) and a kinetic current density of 39.3 mA cm -2 at 0.80 V versus RHE (3.1 times that of Pt/C) in 0.1 M KOH, and excellent stability and methanol tolerance. It also demonstrated ORR activity comparable to and stability much higher than those of Pt/C in acidic and neutral electrolytes. Various characterization techniques, including X-ray absorption spectroscopy, revealed that the superior activity and strong stability of Co-N-C originated from the intense interaction between Co and N, the high content of ORR active pyridinic and pyrrolic N, and the large specific surface area.« less

Calculation of the Relative Chemical Stabilities of Proteins as a Function of Temperature and Redox Chemistry in a Hot Spring

PubMed Central

Dick, Jeffrey M.; Shock, Everett L.

2011-01-01

Uncovering the chemical and physical links between natural environments and microbial communities is becoming increasingly amenable owing to geochemical observations and metagenomic sequencing. At the hot spring known as Bison Pool in Yellowstone National Park, the cooling of the water in the outflow channel is associated with an increase in oxidation potential estimated from multiple field-based measurements. Representative groups of proteins whose sequences were derived from metagenomic data also exhibit an increase in average oxidation state of carbon in the protein molecules with distance from the hot-spring source. The energetic requirements of reactions to form selected proteins used in the model were computed using amino-acid group additivity for the standard molal thermodynamic properties of the proteins, and the relative chemical stabilities of the proteins were investigated by varying temperature, pH and oxidation state, expressed as activity of dissolved hydrogen. The relative stabilities of the proteins were found to track the locations of the sampling sites when the calculations included a function for hydrogen activity that increases with temperature and is higher, or more reducing, than values consistent with measurements of dissolved oxygen, sulfide and oxidation-reduction potential in the field. These findings imply that spatial patterns in the amino acid compositions of proteins can be linked, through energetics of overall chemical reactions representing the formation of the proteins, to the environmental conditions at this hot spring, even if microbial cells maintain considerably different internal conditions. Further applications of the thermodynamic calculations are possible for other natural microbial ecosystems. PMID:21853048

Concurrent temporal stability of the apparent electrical conductivity and soil water content

USDA-ARS?s Scientific Manuscript database

Knowledge of spatio-temporal soil water content (SWC) variability within agricultural fields is useful to improve crop management. Spatial patterns of soil water contents can be characterized using the temporal stability analysis, however high density sampling is required. Soil apparent electrical c...

Induced matter brane gravity and Einstein static universe

DOE Office of Scientific and Technical Information (OSTI.GOV)

Heydarzade, Y.; Darabi, F., E-mail: heydarzade@azaruniv.edu, E-mail: f.darabi@azaruniv.edu

We investigate stability of the Einstein static universe against the scalar, vector and tensor perturbations in the context of induced matter brane gravity. It is shown that in the framework of this model, the Einstein static universe has a positive spatial curvature. In contrast to the classical general relativity, it is found that a stable Einstein static universe against the scalar perturbations does exist provided that the variation of time dependent geometrical equation of state parameter is proportional to the minus of the variation of the scale factor, δ ω{sub g}(t) = −Cδ a(t). We obtain neutral stability against the vector perturbations, and themore » stability against the tensor perturbations is guaranteed due to the positivity of the spatial curvature of the Einstein static universe in induced matter brane gravity.« less

Stability of spatial distributions of stink bugs, boll injury, and NDVI in cotton

USDA-ARS?s Scientific Manuscript database

A two-year study was conducted to determine the degree of aggregation of thrips, stink bugs, and aphids in cotton, Gossypium hirsutum L., and their spatial association with soil apparent electrical conductivity (ECa), a multispectral vegetation index (Normalized Difference Vegetation Index [NDVI]), ...

Postural stabilization from fingertip contact II. Relationships between age, tactile sensibility and magnitude of contact forces.

PubMed

Tremblay, François; Mireault, Annie-Claude; Dessureault, Liam; Manning, Hélène; Sveistrup, Heidi

2005-07-01

In the present report, we extend our previous observations on the effect of age on postural stabilization from fingertip contact (Exp Brain Res 157 (2004) 275) to examine the possible influence of sensory thresholds measured at the fingertip on the magnitude of contact forces. Participants (young, n=25, 19-32 years; old, n=35, 60-86 years) underwent psychophysical testing of the right index finger to determine thresholds for spatial acuity, pressure sensitivity and kinesthetic acuity. Spatial acuity was determined from the ability to detect gaps of different widths, while Semmes-Weinstein monofilaments were used for pressure sensitivity. Kinesthetic acuity was determined by asking participants to discriminate plates of different thicknesses using a thumb-index precision grip. These tests were selected on the basis that each reflected different sensory coding mechanisms (resolution of spatial stimuli, detection of mechanical forces and integration of multi-sensory inputs for hand conformation) and thus provided specific information about the integrity and function of mechanoreceptive afferents innervating the hand. After log transformation, thresholds were first examined to determine the influence of age (young and old) and gender (male, female) on tactile acuity. Sensory thresholds were then entered into multiple linear regression models to examine their ability to predict fingertip contact forces (normal and tangential) applied to a smooth surface when subjects stood with eyes closed on either a firm or a compliant support surface. As expected, age exerted a significant effect (p<0.01) on all three thresholds, but its impact was greater on spatial acuity than on pressure sensitivity or kinesthetic acuity. Gender had a marginal impact on pressure sensitivity thresholds only. The regression analyses revealed that tactile thresholds determined at the index fingertip accounted for a substantial proportion of the variance (up to 30%) seen in the contact forces deployed on the touch-plate, especially those exerted in the normal direction. The same analyses further revealed that much of the variance explained by the models arose from inter-individual differences in tactile spatial acuity and not from differences in pressure sensitivity or in kinesthetic acuity. Thus, of all three tests, the spatial acuity task was the most sensitive at detecting differences in hand sensibility both within and between age groups and, accordingly, was also better at predicting the magnitude of fingertip forces deployed for postural stabilization. Since spatial acuity is critically dependent upon innervation density, we conclude that the degree of functional innervation at the fingertip was likely an important factor in determining the capacity of older participants to use contact cues for stability purposes, forcing the most affected individuals to exert unusually high pressures in order to achieve stabilization in the presence of reduced tactile inputs arising from contact with the touched surface.

Spatial encoding in spinal sensorimotor circuits differs in different wild type mice strains

PubMed Central

Thelin, Jonas; Schouenborg, Jens

2008-01-01

Background Previous studies in the rat have shown that the spatial organisation of the receptive fields of nociceptive withdrawal reflex (NWR) system are functionally adapted through experience dependent mechanisms, termed somatosensory imprinting, during postnatal development. Here we wanted to clarify 1) if mice exhibit a similar spatial encoding of sensory input to NWR as previously found in the rat and 2) if mice strains with a poor learning capacity in various behavioural tests, associated with deficient long term potention, also exhibit poor adaptation of NWR. The organisation of the NWR system in two adult wild type mouse strains with normal long term potentiation (LTP) in hippocampus and two adult wild type mouse strains exhibiting deficiencies in corresponding LTP were used and compared to previous results in the rat. Receptive fields of reflexes in single hindlimb muscles were mapped with CO2 laser heat pulses. Results While the spatial organisation of the nociceptive receptive fields in mice with normal LTP were very similar to those in rats, the LTP impaired strains exhibited receptive fields of NWRs with aberrant sensitivity distributions. However, no difference was found in NWR thresholds or onset C-fibre latencies suggesting that the mechanisms determining general reflex sensitivity and somatosensory imprinting are different. Conclusion Our results thus confirm that sensory encoding in mice and rat NWR is similar, provided that mice strains with a good learning capability are studied and raise the possibility that LTP like mechanisms are involved in somatosensory imprinting. PMID:18495020

Spatial Distribution of a Large Herbivore Community at Waterholes: An Assessment of Its Stability over Years in Hwange National Park, Zimbabwe.

PubMed

Chamaillé-Jammes, Simon; Charbonnel, Anaïs; Dray, Stéphane; Madzikanda, Hillary; Fritz, Hervé

2016-01-01

The spatial structuring of populations or communities is an important driver of their functioning and their influence on ecosystems. Identifying the (in)stability of the spatial structure of populations is a first step towards understanding the underlying causes of these structures. Here we studied the relative importance of spatial vs. interannual variability in explaining the patterns of abundance of a large herbivore community (8 species) at waterholes in Hwange National Park (Zimbabwe). We analyzed census data collected over 13 years using multivariate methods. Our results showed that variability in the census data was mostly explained by the spatial structure of the community, as some waterholes had consistently greater herbivore abundance than others. Some temporal variability probably linked to Park-scale migration dependent on annual rainfall was noticeable, however. Once this was accounted for, little temporal variability remained to be explained, suggesting that other factors affecting herbivore abundance over time had a negligible effect at the scale of the study. The extent of spatial and temporal variability in census data was also measured for each species. This study could help in projecting the consequences of surface water management, and more generally presents a methodological framework to simultaneously address the relative importance of spatial vs. temporal effects in driving the distribution of organisms across landscapes.

Spatial Distribution of a Large Herbivore Community at Waterholes: An Assessment of Its Stability over Years in Hwange National Park, Zimbabwe

PubMed Central

Chamaillé-Jammes, Simon; Charbonnel, Anaïs; Dray, Stéphane; Madzikanda, Hillary; Fritz, Hervé

2016-01-01

The spatial structuring of populations or communities is an important driver of their functioning and their influence on ecosystems. Identifying the (in)stability of the spatial structure of populations is a first step towards understanding the underlying causes of these structures. Here we studied the relative importance of spatial vs. interannual variability in explaining the patterns of abundance of a large herbivore community (8 species) at waterholes in Hwange National Park (Zimbabwe). We analyzed census data collected over 13 years using multivariate methods. Our results showed that variability in the census data was mostly explained by the spatial structure of the community, as some waterholes had consistently greater herbivore abundance than others. Some temporal variability probably linked to Park-scale migration dependent on annual rainfall was noticeable, however. Once this was accounted for, little temporal variability remained to be explained, suggesting that other factors affecting herbivore abundance over time had a negligible effect at the scale of the study. The extent of spatial and temporal variability in census data was also measured for each species. This study could help in projecting the consequences of surface water management, and more generally presents a methodological framework to simultaneously address the relative importance of spatial vs. temporal effects in driving the distribution of organisms across landscapes. PMID:27074044

Quantifying Landscape Spatial Pattern: What Is the State of the Art?

Treesearch

Eric J. Gustafson

1998-01-01

Landscape ecology is based on the premise that there are strong links between ecological pattern and ecological function and process. Ecological systems are spatially heterogeneous, exhibiting consid-erable complexity and variability in time and space. This variability is typically represented by categorical maps or by a collection of samples taken at specific spatial...

Spatial scale of similarity as an indicator of metacommunity stability in exploited marine systems.

PubMed

Shackell, Nancy L; Fisher, Jonathan A D; Frank, Kenneth T; Lawton, Peter

2012-01-01

The spatial scale of similarity among fish communities is characteristically large in temperate marine systems: connectivity is enhanced by high rates of dispersal during the larval/juvenile stages and the increased mobility of large-bodied fish. A larger spatial scale of similarity (low beta diversity) is advantageous in heavily exploited systems because locally depleted populations are more likely to be "rescued" by neighboring areas. We explored whether the spatial scale of similarity changed from 1970 to 2006 due to overfishing of dominant, large-bodied groundfish across a 300 000-km2 region of the Northwest Atlantic. Annually, similarities among communities decayed slowly with increasing geographic distance in this open system, but through time the decorrelation distance declined by 33%, concomitant with widespread reductions in biomass, body size, and community evenness. The decline in connectivity stemmed from an erosion of community similarity among local subregions separated by distances as small as 100 km. Larger fish, of the same species, contribute proportionally more viable offspring, so observed body size reductions will have affected maternal output. The cumulative effect of nonlinear maternal influences on egg/larval quality may have compromised the spatial scale of effective larval dispersal, which may account for the delayed recovery of certain member species. Our study adds strong support for using the spatial scale of similarity as an indicator of metacommunity stability both to understand the spatial impacts of exploitation and to refine how spatial structure is used in management plans.

Amorphization strategy affects the stability and supersaturation profile of amorphous drug nanoparticles.

PubMed

Cheow, Wean Sin; Kiew, Tie Yi; Yang, Yue; Hadinoto, Kunn

2014-05-05

Amorphous drug nanoparticles have recently emerged as a promising bioavailability enhancement strategy of poorly soluble drugs attributed to the high supersaturation solubility generated by the amorphous state and fast dissolution afforded by the nanoparticles. Herein we examine the effects of two amorphization strategies in the nanoscale, i.e., (1) molecular mobility restrictions and (2) high energy surface occupation, both by polymer excipient stabilizers, on the (i) morphology, (ii) colloidal stability, (iii) drug loading, (iv) amorphous state stability after three-month storage, and (v) in vitro supersaturation profiles, using itraconazole (ITZ) as the model drug. Drug-polyelectrolyte complexation is employed in the first strategy to prepare amorphous ITZ nanoparticles using dextran sulfate as the polyelectrolyte (ITZ nanoplex), while the second strategy employs pH-shift precipitation using hydroxypropylmethylcellulose as the surface stabilizer (nano-ITZ), with both strategies resulting in >90% ITZ utilization. Both amorphous ITZ nanoparticles share similar morphology (∼300 nm spheres) with the ITZ nanoplex exhibiting better colloidal stability, albeit at lower ITZ loading (65% versus 94%), due to the larger stabilizer amount used. The ITZ nanoplex also exhibits superior amorphous state stability, attributed to the ITZ molecular mobility restriction by electrostatic complexation with dextran sulfate. The higher stability, however, is obtained at the expense of slower supersaturation generation, which is maintained over a prolonged period, compared to the nano-ITZ. The present results signify the importance of selecting the optimal amorphization strategy, in addition to formulating the excipient stabilizers, to produce amorphous drug nanoparticles having the desired characteristics.

Stability of Two Piagetian Scales with Severely and Profoundly Retarded Children.

ERIC Educational Resources Information Center

Silverstein, A. B.; And Others

1981-01-01

Corman and Escalona's scales for Object Permanence and Spatial Relationships were administered to 98 severely and profoundly retarded children on three occasions, with intervals of six months between successive administrations. The findings demonstrated the high stability of the scales when environmental conditions are themselves highly stable.…

Cellular Factors Shape 3D Genome Landscape

Cancer.gov

Researchers, using novel large-scale imaging technology, have mapped the spatial location of individual genes in the nucleus of human cells and identified 50 cellular factors required for the proper 3D positioning of genes. These spatial locations play important roles in gene expression, DNA repair, genome stability, and other cellular activities.

Multi-scale geospatial agroecosystem modeling: A case study on the influence of soil data resolution on carbon budget estimates

EPA Science Inventory

The development of effective measures to stabilize atmospheric 22 CO2 concentration and mitigate negative impacts of climate change requires accurate quantification of the spatial variation and magnitude of the terrestrial carbon (C) flux. However, the spatial pattern and strengt...

Atomic force microscopy investigation of chemically stabilized pericardium tissue.

PubMed

Jastrzebska, M; Barwinski, B; Mróz, I; Turek, A; Zalewska-Rejdak, J; Cwalina, B

2005-04-01

Native and chemically stabilized porcine pericardium tissue was imaged by the contact mode atomic force microscopy (AFM), in air. Chemically stabilized pericardium is used as a tissue-derived biomaterial in various fields of the reconstructive and replacement surgery. Collagen type I is the main component of the fibrous layer of the pericardium tissue. In this study, the surface topography of collagen fibrils in their native state in tissue and after chemical stabilization with different cross-linking reagents: glutaraldehyde (GA), dimethyl suberimidate (DMS) and tannic acid (TA) was investigated. It has been found that chemical stabilization causes considerable changes in the surface topography of collagen fibrils as well as in the spatial organization of the fibrils within the tissue. The observed changes in the D-spacing pattern of the collagen fibril correspond to the formation of intrafibrilar cross-links, whereas formation of interfibrilar cross-links is mainly responsible for the observed tangled spatial arrangement of fibrils and crimp structure of the tissue surface. The crimp structure was distinctly seen for the GA cross-linked tissue. Surface heterogeneity of the cross-linking process was observed for the DMS-stabilized tissue. SDS-PAGE electrophoresis was performed in order to evaluate the stabilization effect of the tissues treated with the cross-linking reagents. It has been found that stabilization with DMS, GA or TA enhances significantly the tissue resistance to SDS/NaCl extraction. The relation between the tissue stability and changes in the topography of the tissue surface was interpreted in terms of different nature of cross-links formed by DMS, GA and TA with collagen.

Noun and Verb Production in Maternal and Child Language: Continuity, Stability, and Prediction across the Second Year of Life

ERIC Educational Resources Information Center

Longobardi, Emiddia; Spataro, Pietro; Putnick, Diane L.; Bornstein, Marc H.

2016-01-01

The present study examined continuity/discontinuity and stability/instability of noun and verb production measures in 30 child-mother dyads observed at 16 and 20 months, and predictive relations with the acquisition of nouns and verbs at 24 months. Children exhibited significant discontinuity and robust stability in the frequency of nouns and…

Effect of aging on dynamic postural stability and variability during a multi-directional lean and reach object transportation task.

PubMed

Huntley, Andrew H; Zettel, John L; Vallis, Lori Ann

2016-01-01

A "reach and transport object" task that represents common activities of daily living may provide improved insight into dynamic postural stability and movement variability deficits in older adults compared to previous lean to reach and functional reach tests. Healthy young and older, community dwelling adults performed three same elevation object transport tasks and two multiple elevation object transport tasks under two self-selected speeds, self-paced and fast-paced. Dynamic postural stability and movement variability was quantified by whole-body center of mass motion. Older adults demonstrated significant decrements in frontal plane stability during the multiple elevation tasks while exhibiting the same movement variability as their younger counterparts, regardless of task speed. Interestingly, older adults did not exhibit a tradeoff in maneuverability in favour of maintaining stability throughout the tasks, as has previously been reported. In conclusion, the multi-planar, ecologically relevant tasks employed in the current study were specific enough to elucidate decrements in dynamic stability, and thus may be useful for assessing fall risk in older adults with suspected postural instability. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

[Thermostabilization of glutamin(asparagin)ase from Pseudomonas aurantica BKMB-548].

PubMed

Kabanova, E A; Lebedeva, Z I; Berezov, T T

1985-01-01

In studies on kinetics of thermoinactivation of glutaminase (asparaginase) from Ps. arantiaca BKMB-548 at 50 degrees and pH 7.0 in presence or in absence of L-glutamate the enzyme inactivation was found to obey the first order equation. Both the glutaminase and asparaginase activities decreased at a similar rate. L-Glutamate stabilized the enzyme due to direct interaction with its molecule. Stability of the complex formed was evaluated quantitatively. L-Glutamate reacted apparently with a specific site on the surface of the enzyme molecule; Kdiss was 0.42 +/- 0.03 mM at pH 7.0 and 50 degrees. No cooperative effect was found. L-Aspartate protected the enzyme completely; stabilizing effects of L-cysteine, L-serine and glycine were similar to the effect of L-glutamate (94%, 84%, 83% and 82%, respectively). At the same time, glutarate, succinate, alpha-ketobutyrate, alpha-ketoglutarate, gamma-aminobutyrate and N-benzoyl glutamate did not exhibit the stabilization effect. The data obtained suggest that the high stabilizing effect might exhibit only the substances containing simultaneously free alpha-NH2 and alpha-COOH groups in a molecule, whereas presence of COOH groups at beta--or gamma-carbon atoms was not essential for the stabilizing effect.

Flexibility and Stability Trade-Off in Active Site of Cold-Adapted Pseudomonas mandelii Esterase EstK.

PubMed

Truongvan, Ngoc; Jang, Sei-Heon; Lee, ChangWoo

2016-06-28

Cold-adapted enzymes exhibit enhanced conformational flexibility, especially in their active sites, as compared with their warmer-temperature counterparts. However, the mechanism by which cold-adapted enzymes maintain their active site stability is largely unknown. In this study, we investigated the role of conserved D308-Y309 residues located in the same loop as the catalytic H307 residue in the cold-adapted esterase EstK from Pseudomonas mandelii. Mutation of D308 and/or Y309 to Ala or deletion resulted in increased conformational flexibility. Particularly, the D308A or Y309A mutant showed enhanced substrate affinity and catalytic rate, as compared with wild-type EstK, via enlargement of the active site. However, all mutant EstK enzymes exhibited reduced thermal stability. The effect of mutation was greater for D308 than Y309. These results indicate that D308 is not preferable for substrate selection and catalytic activity, whereas hydrogen bond formation involving D308 is critical for active site stabilization. Taken together, conformation of the EstK active site is constrained via flexibility-stability trade-off for enzyme catalysis and thermal stability. Our study provides further insights into active site stabilization of cold-adapted enzymes.

Stability of lipid encapsulated ferulic acid particles

USDA-ARS?s Scientific Manuscript database

Encapsulation of bioactive compounds by a solid lipid matrix provides stability and a mechanism for controlled release in formulated products. Phenolic compounds exhibit antioxidant and antimicrobial activities and have applications as functional food and feed additives. Ferulic acid, a common pheno...

a Simple Spatially Weighted Measure of Temporal Stability for Data with Limited Temporal Observations

NASA Astrophysics Data System (ADS)

Piburn, J.; Stewart, R.; Morton, A.

2017-10-01

Identifying erratic or unstable time-series is an area of interest to many fields. Recently, there have been successful developments towards this goal. These new developed methodologies however come from domains where it is typical to have several thousand or more temporal observations. This creates a challenge when attempting to apply these methodologies to time-series with much fewer temporal observations such as for socio-cultural understanding, a domain where a typical time series of interest might only consist of 20-30 annual observations. Most existing methodologies simply cannot say anything interesting with so few data points, yet researchers are still tasked to work within in the confines of the data. Recently a method for characterizing instability in a time series with limitedtemporal observations was published. This method, Attribute Stability Index (ASI), uses an approximate entropy based method tocharacterize a time series' instability. In this paper we propose an explicitly spatially weighted extension of the Attribute StabilityIndex. By including a mechanism to account for spatial autocorrelation, this work represents a novel approach for the characterizationof space-time instability. As a case study we explore national youth male unemployment across the world from 1991-2014.

Cerebral specialization for spatial processing in adults with Down syndrome.

PubMed

Elliott, D; Pollock, B J; Chua, R; Weeks, D J

1995-05-01

Cerebral specialization for spatial processing in adults with Down syndrome was examined. In the first experiment, both control and right-handed subjects with Down syndrome exhibited no lateral advantage in a dihaptic shape-matching task, whereas left-handed subjects with Down syndrome displayed an expected left-hand advantage. In a visual field dot enumeration task in the second experiment, all groups exhibited left-field superiority. Thus, atypical cerebral organization of function in adults with Down syndrome appears to be confined to speech perception (Elliott & Weeks, 1993).

Rational design of Pleurotus eryngii versatile ligninolytic peroxidase for enhanced pH and thermal stability through structure-based protein engineering.

PubMed

Gao, Yu; Li, Jian-Jun; Zheng, Lanyan; Du, Yuguang

2017-11-01

Versatile peroxidase (VP) from Pleurotus eryngii is a high redox potential peroxidase. It has aroused great biotechnological interest due to its ability to oxidize a wide range of substrates, but its application is still limited due to low pH and thermal stability. Since CiP (Coprinopsis cinerea peroxidase) and PNP (peanut peroxidase) exhibited higher pH and thermal stability than VP, several motifs, which might contribute to their pH and thermal stability, were identified through structure and sequence alignment. Six VP variants incorporating the beneficial motifs were designed and constructed. Most variants were nearly completely inactivated except V1 (Variant 1) and V4. V1 showed comparable activity to WT VP against ABTS, while V4 exhibited reduced activity. V1 displayed improved pH stability than WT VP, at pH 3.0 in particular, whereas the pH stability of V4 did not change a lot. The thermal stabilities of V1 and V4 were enhanced with T50 raised by 3°C. The results demonstrated that variants containing the beneficial motifs of CiP and PNP conferred VP with improved pH and thermal stability. © The Author 2017. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

The Stability of DSM Personality Disorders over Twelve to Eighteen Years

PubMed Central

Nestadt, Gerald; Di, Chongzhi; Samuels, J F; Bienvenu, O J; Reti, I M; Costa, P; Eaton, William W; Bandeen-Roche, Karen

2009-01-01

Background Stability of personality disorders is assumed in most nomenclatures; however, the evidence for this is limited and inconsistent. The aim of this study is to investigate the stability of DSM-III personality disorders in a community sample of eastern Baltimore residents unselected for treatment. Methods Two hundred ninety four participants were examined on two occasions by psychiatrists using the same standardized examination twelve to eighteen years apart. All the DSM-III criteria for personality disorders were assessed. Item-response analysis was adapted into two approaches to assess the agreement between the personality measures on the two occasions. The first approach estimated stability in the underlying disorder, correcting for error in trait measurement, and the second approach estimated stability in the measured disorder, without correcting for item unreliability. Results Five of the ten personality disorders exhibited moderate stability in individuals: antisocial, avoidant, borderline, histrionic, and schizotypal. Associated estimated ICCs for stability of underlying disorder over time ranged between approximately 0.4 and 0.7–0.8. A sixth disorder, OCPD, exhibited appreciable stability with estimated ICC of approximately 0.2–0.3. Dependent, narcissistic, paranoid, and schizoid disorders were not demonstrably stable. Conclusions The findings suggest that six of the DSM personality disorder constructs themselves are stable, but that specific traits within the DSM categories are both of lesser importance than the constructs themselves and require additional specification. PMID:19656527

Image Understanding and Information Extraction\\

DTIC Science & Technology

1977-11-01

mentation and generalization of DeCarlo’s Nyquist-like stability test [15,161. The last step of the procedure is to check whether this zero ...Several general sta- bility theorems which relate stability to the zero set of B(w,z) have been presented. These theorems led to the conclusion that...Spatial Stochastic Model for Contextual Pattern Recognition . ° . .............. 88 T. S. Yu and K. S. Fu V. PREPROCESSING 1. Stability of General Two

Design and physicochemical stability studies of paediatric oral formulations of sildenafil.

PubMed

Provenza, N; Calpena, A C; Mallandrich, M; Halbaut, L; Clares, B

2014-01-02

Personalized medicine is a challenging research area in paediatric treatments. Elaborating new paediatric formulations when no commercial forms are available is a common practice in pharmacy laboratories; among these, oral liquid formulations are the most common. But due to the lack of specialized equipment, frequently studies to assure the efficiency and safety of the final medicine cannot be carried out. Thus the purpose of this work was the development, characterization and stability evaluation of two oral formulations of sildenafil for the treatment of neonatal persistent pulmonary hypertension. After the establishment of a standard operating procedure (SOP) and elaboration, the physicochemical stability parameters appearance, pH, particle size, rheological behaviour and drug content of formulations were evaluated at three different temperatures for 90 days. Equally, prediction of long term stability, as well as, microbiological stability was performed. Formulations resulted in a suspension and a solution slightly coloured exhibiting fruity odour. Formulation I (suspension) exhibited the best physicochemical properties including Newtonian behaviour and uniformity of API content above 90% to assure an exact dosification process. Copyright © 2013 Elsevier B.V. All rights reserved.

Boosting antibody developability through rational sequence optimization.

PubMed

Seeliger, Daniel; Schulz, Patrick; Litzenburger, Tobias; Spitz, Julia; Hoerer, Stefan; Blech, Michaela; Enenkel, Barbara; Studts, Joey M; Garidel, Patrick; Karow, Anne R

2015-01-01

The application of monoclonal antibodies as commercial therapeutics poses substantial demands on stability and properties of an antibody. Therapeutic molecules that exhibit favorable properties increase the success rate in development. However, it is not yet fully understood how the protein sequences of an antibody translates into favorable in vitro molecule properties. In this work, computational design strategies based on heuristic sequence analysis were used to systematically modify an antibody that exhibited a tendency to precipitation in vitro. The resulting series of closely related antibodies showed improved stability as assessed by biophysical methods and long-term stability experiments. As a notable observation, expression levels also improved in comparison with the wild-type candidate. The methods employed to optimize the protein sequences, as well as the biophysical data used to determine the effect on stability under conditions commonly used in the formulation of therapeutic proteins, are described. Together, the experimental and computational data led to consistent conclusions regarding the effect of the introduced mutations. Our approach exemplifies how computational methods can be used to guide antibody optimization for increased stability.

Exotic singularities and spatially curved loop quantum cosmology

DOE Office of Scientific and Technical Information (OSTI.GOV)

Singh, Parampreet; Perimeter Institute for Theoretical Physics, 31 Caroline Street North, Waterloo, Ontario N2L 2Y5; Vidotto, Francesca

2011-03-15

We investigate the occurrence of various exotic spacelike singularities in the past and the future evolution of k={+-}1 Friedmann-Robertson-Walker model and loop quantum cosmology using a sufficiently general phenomenological model for the equation of state. We highlight the nontrivial role played by the intrinsic curvature for these singularities and the new physics which emerges at the Planck scale. We show that quantum gravity effects generically resolve all strong curvature singularities including big rip and big freeze singularities. The weak singularities, which include sudden and big brake singularities, are ignored by quantum gravity when spatial curvature is negative, as was previouslymore » found for the spatially flat model. Interestingly, for the spatially closed model there exist cases where weak singularities may be resolved when they occur in the past evolution. The spatially closed model exhibits another novel feature. For a particular class of equation of state, this model also exhibits an additional physical branch in loop quantum cosmology, a baby universe separated from the parent branch. Our analysis generalizes previous results obtained on the resolution of strong curvature singularities in flat models to isotropic spacetimes with nonzero spatial curvature.« less

Submarine slope failures due to pipe structure formation.

PubMed

Elger, Judith; Berndt, Christian; Rüpke, Lars; Krastel, Sebastian; Gross, Felix; Geissler, Wolfram H

2018-02-19

There is a strong spatial correlation between submarine slope failures and the occurrence of gas hydrates. This has been attributed to the dynamic nature of gas hydrate systems and the potential reduction of slope stability due to bottom water warming or sea level drop. However, 30 years of research into this process found no solid supporting evidence. Here we present new reflection seismic data from the Arctic Ocean and numerical modelling results supporting a different link between hydrates and slope stability. Hydrates reduce sediment permeability and cause build-up of overpressure at the base of the gas hydrate stability zone. Resulting hydro-fracturing forms pipe structures as pathways for overpressured fluids to migrate upward. Where these pipe structures reach shallow permeable beds, this overpressure transfers laterally and destabilises the slope. This process reconciles the spatial correlation of submarine landslides and gas hydrate, and it is independent of environmental change and water depth.

Waves on radial film flows

NASA Astrophysics Data System (ADS)

Cholemari, Murali R.; Arakeri, Jaywant H.

2005-08-01

We study the stability of surface waves on the radial film flow created by a vertical cylindrical water jet striking a horizontal plate. In such flows, surface waves have been found to be unstable and can cause transition to turbulence. This surface-wave-induced transition is different from the well-known Tollmien-Schlichting wave-induced transition. The present study aims at understanding the instability and the transition process. We do a temporal stability analysis by assuming the flow to be locally two-dimensional but including spatial variations to first order in the basic flow. The waves are found to be dispersive, mostly unstable, and faster than the mean flow. Spatial variation is the major destabilizing factor. Experiments are done to test the results of the linear stability analysis and to document the wave breakup and transition. Comparison between theory and experiments is fairly good and indicates the adequacy of the model.

Free-carrier-induced soliton fission unveiled by in situ measurements in nanophotonic waveguides

DOE Office of Scientific and Technical Information (OSTI.GOV)

Husko, Chad; Wulf, Matthias; Lefrancois, Simon

Solitons are localized waves formed by a balance of focusing and defocusing effects. These nonlinear waves exist in diverse forms of matter yet exhibit similar properties including stability, periodic recurrence and particle-like trajectories. One important property is soliton fission, a process by which an energetic higher-order soliton breaks apart due to dispersive or nonlinear perturbations. Here we demonstrate through both experiment and theory that nonlinear photocarrier generation can induce soliton fission. Using near-field measurements, we directly observe the nonlinear spatial and temporal evolution of optical pulses in situ in a nanophotonic semiconductor waveguide. We develop an analytic formalism describing themore » free-carrier dispersion (FCD) perturbation and show the experiment exceeds the minimum threshold by an order of magnitude. We confirm these observations with a numerical nonlinear Schrodinger equation model. Finally, these results provide a fundamental explanation and physical scaling of optical pulse evolution in free-carrier media and could enable improved supercontinuum sources in gas based and integrated semiconductor waveguides.« less

Likelihood testing of seismicity-based rate forecasts of induced earthquakes in Oklahoma and Kansas

USGS Publications Warehouse

Moschetti, Morgan P.; Hoover, Susan M.; Mueller, Charles

2016-01-01

Likelihood testing of induced earthquakes in Oklahoma and Kansas has identified the parameters that optimize the forecasting ability of smoothed seismicity models and quantified the recent temporal stability of the spatial seismicity patterns. Use of the most recent 1-year period of earthquake data and use of 10–20-km smoothing distances produced the greatest likelihood. The likelihood that the locations of January–June 2015 earthquakes were consistent with optimized forecasts decayed with increasing elapsed time between the catalogs used for model development and testing. Likelihood tests with two additional sets of earthquakes from 2014 exhibit a strong sensitivity of the rate of decay to the smoothing distance. Marked reductions in likelihood are caused by the nonstationarity of the induced earthquake locations. Our results indicate a multiple-fold benefit from smoothed seismicity models in developing short-term earthquake rate forecasts for induced earthquakes in Oklahoma and Kansas, relative to the use of seismic source zones.

Long-term dynamics of winter and summer annual communities in the Chihuahuan Desert

USGS Publications Warehouse

Guo, Q.; Brown, J.H.; Valone, T.J.

2002-01-01

Using 15 years of census data from permanent quadrats, this paper compared the characteristics and temporal dynamics of these two distinct, spatially coexistent but temporally segregated communities. Although the total number of summer annual species recorded during our 15 years observation was higher than winter annuals, the average number of species observed each year was higher in the winter community. The winter community exhibited lower temporal variation in total plant abundance and populations of individual species, lower species turnover rate and higher evenness than the summer community. The higher seasonal species diversity (i.e., number of species observed in each season) in winters rather than the overall special pool (over 15 yrs) may be responsible for the greater community stability of winter annuals. The difference in long-term community dynamics between the two communities of annuals plants are likely due to the differences in total species pool, life history traits (e.g., seed size), and seasonal climatic regimes.

An Apicomplexan Actin-Binding Protein Serves as a Connector and Lipid Sensor to Coordinate Motility and Invasion.

PubMed

Jacot, Damien; Tosetti, Nicolò; Pires, Isa; Stock, Jessica; Graindorge, Arnault; Hung, Yu-Fu; Han, Huijong; Tewari, Rita; Kursula, Inari; Soldati-Favre, Dominique

2016-12-14

Apicomplexa exhibit a unique form of substrate-dependent gliding motility central for host cell invasion and parasite dissemination. Gliding is powered by rearward translocation of apically secreted transmembrane adhesins via their interaction with the parasite actomyosin system. We report a conserved armadillo and pleckstrin homology (PH) domain-containing protein, termed glideosome-associated connector (GAC), that mediates apicomplexan gliding motility, invasion, and egress by connecting the micronemal adhesins with the actomyosin system. TgGAC binds to and stabilizes filamentous actin and specifically associates with the transmembrane adhesin TgMIC2. GAC localizes to the apical pole in invasive stages of Toxoplasma gondii and Plasmodium berghei, and apical positioning of TgGAC depends on an apical lysine methyltransferase, TgAKMT. GAC PH domain also binds to phosphatidic acid, a lipid mediator associated with microneme exocytosis. Collectively, these findings indicate a central role for GAC in spatially and temporally coordinating gliding motility and invasion. Copyright © 2016 Elsevier Inc. All rights reserved.

Long-lived monolithic micro-optics for multispectral GRIN applications.

PubMed

Lepicard, Antoine; Bondu, Flavie; Kang, Myungkoo; Sisken, Laura; Yadav, Anupama; Adamietz, Frederic; Rodriguez, Vincent; Richardson, Kathleen; Dussauze, Marc

2018-05-09

The potential for realizing robust, monolithic, near-surface refractive micro-optic elements with long-lived stability is demonstrated in visible and infrared transmitting glasses capable of use in dual band applications. Employing an enhanced understanding of glass chemistry and geometric control of mobile ion migration made possible with electrode patterning, flat, permanent, thermally-poled micro-optic structures have been produced and characterized. Sub-surface (t~5-10 µm) compositional and structural modification during the poling process results in formation of spatially-varying refractive index profiles, exhibiting induced Δn changes up to 5 × 10 -2 which remain stable for >15 months. The universality of this approach applied to monolithic vis-near infrared [NIR] oxide and NIR-midwave infrared [MIR] chalcogenide glass materials is demonstrated for the first time. Element size, shape and gradient profile variation possible through pattern design and fabrication is shown to enable a variety of design options not possible using other GRIN process methodologies.

Free-carrier-induced soliton fission unveiled by in situ measurements in nanophotonic waveguides

DOE PAGES

Husko, Chad; Wulf, Matthias; Lefrancois, Simon; ...

2016-04-15

Solitons are localized waves formed by a balance of focusing and defocusing effects. These nonlinear waves exist in diverse forms of matter yet exhibit similar properties including stability, periodic recurrence and particle-like trajectories. One important property is soliton fission, a process by which an energetic higher-order soliton breaks apart due to dispersive or nonlinear perturbations. Here we demonstrate through both experiment and theory that nonlinear photocarrier generation can induce soliton fission. Using near-field measurements, we directly observe the nonlinear spatial and temporal evolution of optical pulses in situ in a nanophotonic semiconductor waveguide. We develop an analytic formalism describing themore » free-carrier dispersion (FCD) perturbation and show the experiment exceeds the minimum threshold by an order of magnitude. We confirm these observations with a numerical nonlinear Schrodinger equation model. Finally, these results provide a fundamental explanation and physical scaling of optical pulse evolution in free-carrier media and could enable improved supercontinuum sources in gas based and integrated semiconductor waveguides.« less

An effective immunization strategy for airborne epidemics in modular and hierarchical social contact network

NASA Astrophysics Data System (ADS)

Song, Zhichao; Ge, Yuanzheng; Luo, Lei; Duan, Hong; Qiu, Xiaogang

2015-12-01

Social contact between individuals is the chief factor for airborne epidemic transmission among the crowd. Social contact networks, which describe the contact relationships among individuals, always exhibit overlapping qualities of communities, hierarchical structure and spatial-correlated. We find that traditional global targeted immunization strategy would lose its superiority in controlling the epidemic propagation in the social contact networks with modular and hierarchical structure. Therefore, we propose a hierarchical targeted immunization strategy to settle this problem. In this novel strategy, importance of the hierarchical structure is considered. Transmission control experiments of influenza H1N1 are carried out based on a modular and hierarchical network model. Results obtained indicate that hierarchical structure of the network is more critical than the degrees of the immunized targets and the modular network layer is the most important for the epidemic propagation control. Finally, the efficacy and stability of this novel immunization strategy have been validated as well.

Wave of chaos in a spatial eco-epidemiological system: Generating realistic patterns of patchiness in rabbit-lynx dynamics.

PubMed

Upadhyay, Ranjit Kumar; Roy, Parimita; Venkataraman, C; Madzvamuse, A

2016-11-01

In the present paper, we propose and analyze an eco-epidemiological model with diffusion to study the dynamics of rabbit populations which are consumed by lynx populations. Existence, boundedness, stability and bifurcation analyses of solutions for the proposed rabbit-lynx model are performed. Results show that in the presence of diffusion the model has the potential of exhibiting Turing instability. Numerical results (finite difference and finite element methods) reveal the existence of the wave of chaos and this appears to be a dominant mode of disease dispersal. We also show the mechanism of spatiotemporal pattern formation resulting from the Hopf bifurcation analysis, which can be a potential candidate for understanding the complex spatiotemporal dynamics of eco-epidemiological systems. Implications of the asymptotic transmission rate on disease eradication among rabbit population which in turn enhances the survival of Iberian lynx are discussed. Crown Copyright © 2016. Published by Elsevier Inc. All rights reserved.

Electronically conducting hybrid material as high performance catalyst support for electrocatalytic application

NASA Astrophysics Data System (ADS)

Rajesh, B.; Ravindranathan Thampi, K.; Bonard, J.-M.; Mathieu, H. J.; Xanthopoulos, N.; Viswanathan, B.

The electronically conducting hybrid material based on transition metal oxide and conducting polymer has been used as the catalyst support for Pt nanoparticles. The Pt nanoparticles loaded hybrid organic (polyaniline)-inorganic (vanadium pentoxide) composite has been used as the electrode material for methanol oxidation, a reaction of importance for the development of direct methanol fuel cells (DMFC). The hybrid material exhibited excellent electrochemical and thermal stability in comparison to the physical mixture of conducting polymer and transition metal oxide. The Pt nanoparticles loaded hybrid material exhibited high electrocatalytic activity and stability for methanol oxidation in comparison to the Pt supported on the Vulcan XC 72R carbon support. The higher activity and stability is attributed to the better CO tolerance of the composite material.

Spectral and Polarization Sensitivity of the Dipteran Visual System

PubMed Central

McCann, Gilbert D.; Arnett, David W.

1972-01-01

Spectral and polarization sensitivity measurements were made at several levels (retina, first and third optic ganglion, cervical connective, behavior) of the dipteran visual nervous system. At all levels, it was possible to reveal contributions from the retinular cell subsystem cells 1 to 6 or the retinular cell subsystem cells 7 and 8 or both. Only retinular cells 1 to 6 were directly studied, and all possessed the same spectral sensitivity characterized by two approximately equal sensitivity peaks at 350 and 480 nm. All units of both the sustaining and on-off variety in the first optic ganglion exhibited the same spectral sensitivity as that of retinular cells 1 to 6. It was possible to demonstrate for motion detection and optomotor responses two different spectral sensitivities depending upon the spatial wavelength of the stimulus. For long spatial wavelengths, the spectral sensitivity agreed with retinular cells 1 to 6; however, the spectral sensitivity at short spatial wavelengths was characterized by a single peak at 465 nm reflecting contributions from the (7, 8) subsystem. Although the two subsystems exhibited different spectral sensitivities, the difference was small and no indication of color discrimination mechanisms was observed. Although all retinular cells 1 to 6 exhibited a preferred polarization plane, sustaining and on-off units did not. Likewise, motion detection and optomotor responses were insensitive to the polarization plane for long spatial wavelength stimuli; however, sensitivity to select polarization planes was observed for short spatial wavelengths. PMID:5027759

Local sensitivity to stimulus orientation and spatial frequency within the receptive fields of neurons in visual area 2 of macaque monkeys

PubMed Central

Tao, X.; Zhang, B.; Smith, E. L.; Nishimoto, S.; Ohzawa, I.

2012-01-01

We used dynamic dense noise stimuli and local spectral reverse correlation methods to reveal the local sensitivities of neurons in visual area 2 (V2) of macaque monkeys to orientation and spatial frequency within their receptive fields. This minimized the potentially confounding assumptions that are inherent in stimulus selections. The majority of neurons exhibited a relatively high degree of homogeneity for the preferred orientations and spatial frequencies in the spatial matrix of facilitatory subfields. However, about 20% of all neurons showed maximum orientation differences between neighboring subfields that were greater than 25 deg. The neurons preferring horizontal or vertical orientations showed less inhomogeneity in space than the neurons preferring oblique orientations. Over 50% of all units also exhibited suppressive profiles, and those were more heterogeneous than facilitatory profiles. The preferred orientation and spatial frequency of suppressive profiles differed substantially from those of facilitatory profiles, and the neurons with suppressive subfields had greater orientation selectivity than those without suppressive subfields. The peak suppression occurred with longer delays than the peak facilitation. These results suggest that the receptive field profiles of the majority of V2 neurons reflect the orderly convergence of V1 inputs over space, but that a subset of V2 neurons exhibit more complex response profiles having both suppressive and facilitatory subfields. These V2 neurons with heterogeneous subfield profiles could play an important role in the initial processing of complex stimulus features. PMID:22114163

Aqueous synthesis of highly luminescent AgInS2-ZnS quantum dots and their biological applications

NASA Astrophysics Data System (ADS)

Regulacio, Michelle D.; Win, Khin Yin; Lo, Seong Loong; Zhang, Shuang-Yuan; Zhang, Xinhai; Wang, Shu; Han, Ming-Yong; Zheng, Yuangang

2013-02-01

Highly emissive and air-stable AgInS2-ZnS quantum dots (ZAIS QDs) with quantum yields of up to 20% have been successfully synthesized directly in aqueous media in the presence of polyacrylic acid (PAA) and mercaptoacetic acid (MAA) as stabilizing and reactivity-controlling agents. The as-prepared water-dispersible ZAIS QDs are around 3 nm in size, possess the tetragonal chalcopyrite crystal structure, and exhibit long fluorescence lifetimes (>100 ns). In addition, these ZAIS QDs are found to exhibit excellent optical and colloidal stability in physiologically relevant pH values as well as very low cytotoxicity, which render them particularly suitable for biological applications. Their potential use in biological labelling of baculoviral vectors is demonstrated.Highly emissive and air-stable AgInS2-ZnS quantum dots (ZAIS QDs) with quantum yields of up to 20% have been successfully synthesized directly in aqueous media in the presence of polyacrylic acid (PAA) and mercaptoacetic acid (MAA) as stabilizing and reactivity-controlling agents. The as-prepared water-dispersible ZAIS QDs are around 3 nm in size, possess the tetragonal chalcopyrite crystal structure, and exhibit long fluorescence lifetimes (>100 ns). In addition, these ZAIS QDs are found to exhibit excellent optical and colloidal stability in physiologically relevant pH values as well as very low cytotoxicity, which render them particularly suitable for biological applications. Their potential use in biological labelling of baculoviral vectors is demonstrated. Electronic supplementary information (ESI) available: Quantum yields, EDX spectrum and photoluminescence decay curves. See DOI: 10.1039/c3nr34159c

Nonlinear stability in reaction-diffusion systems via optimal Lyapunov functions

NASA Astrophysics Data System (ADS)

Lombardo, S.; Mulone, G.; Trovato, M.

2008-06-01

We define optimal Lyapunov functions to study nonlinear stability of constant solutions to reaction-diffusion systems. A computable and finite radius of attraction for the initial data is obtained. Applications are given to the well-known Brusselator model and a three-species model for the spatial spread of rabies among foxes.

Spatio-temporal dynamics of a tree-killing beetle and its predator

Treesearch

Aaron S. Weed; Matthew P. Ayres; Andrew M. Liebhold; Ronald F. Billings

2016-01-01

Resolving linkages between local-scale processes and regional-scale patterns in abundance of interacting species is important for understanding long-term population stability across spatial scales. Landscape patterning in consumer population dynamics may be largely the result of interactions between consumers and their predators, or driven by spatial variation in basal...

Tyrosine Phosphorylation of the Human Serotonin Transporter: A Role in the Transporter Stability and Function

PubMed Central

Annamalai, Balasubramaniam; Mannangatti, Padmanabhan; Arapulisamy, Obulakshmi; Shippenberg, Toni S.; Jayanthi, Lankupalle D.

2012-01-01

The serotonin (5-HT) transporter (SERT) regulates serotoninergic neurotransmission by clearing 5-HT released into the synaptic space. Phosphorylation of SERT on serine and threonine mediates SERT regulation. Whether tyrosine phosphorylation regulates SERT is unknown. Here, we tested the hypothesis that tyrosine-phosphorylation of SERT regulates 5-HT transport. In support of this, alkali-resistant 32P-labeled SERT was found in rat platelets, and Src-tyrosine kinase inhibitor 4-amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo [3,4,d]pyrimidine (PP2) decreased platelet SERT function and expression. In human placental trophoblast cells expressing SERT, PP2 reduced transporter function, expression, and stability. Although siRNA silencing of Src expression decreased SERT function and expression, coexpression of Src resulted in PP2-sensitive increases in SERT function and expression. PP2 treatment markedly decreased SERT protein stability. Compared with WT-SERT, SERT tyrosine mutants Y47F and Y142F exhibited reduced 5-HT transport despite their higher total and cell surface expression levels. Moreover, Src-coexpression increased total and cell surface expression of Y47F and Y142F SERT mutants without affecting their 5-HT transport capacity. It is noteworthy that Y47F and Y142F mutants exhibited higher protein stability compared with WT-SERT. However, similar to WT-SERT, PP2 treatment decreased the stability of Y47F and Y142F mutants. Furthermore, compared with WT-SERT, Y47F and Y142F mutants exhibited lower basal tyrosine phosphorylation and no further enhancement of tyrosine phosphorylation in response to Src coexpression. These results provide the first evidence that SERT tyrosine phosphorylation supports transporter protein stability and 5HT transport. PMID:21992875

Niobium Doped Lanthanum Strontium Ferrite as A Redox-Stable and Sulfur-Tolerant Anode for Solid Oxide Fuel Cells.

PubMed

Li, Jingwei; Wei, Bo; Cao, Zhiqun; Yue, Xing; Zhang, Yaxin; Lü, Zhe

2018-01-10

The Nb-doped lanthanum strontium ferrite perovskite oxide La 0.8 Sr 0.2 Fe 0.9 Nb 0.1 O 3-δ (LSFNb) is evaluated as an anode material in a solid oxide fuel cell (SOFC). The effects of Nb partial substitution in the crystal structure, the electrical conductivity, and the valence of Fe ions are studied. LSFNb exhibits good structural stability in a severe reducing atmosphere at 800 °C, suggesting that high-valent Nb can effectively promote the stability of the lattice structure. The concentration of Fe 2+ increases after Nb doping, as confirmed by X-ray photoelectron spectroscopy. The maximum power density of a thick Sc-stabilized zirconia (ScSZ) electrolyte-supported single cell reached 241.6 mW cm -2 at 800 °C with H 2 as fuel. The cell exhibited excellent stability for 100 h continuous operation without detectable degeneration. Scanning electron microscopy clearly revealed exsolution on the LSFNb surface after operation. Meanwhile, LSFNb particles agglomerated significantly during long-term stability testing. Impedance spectra suggested that both the LSFNb anode and the (La 0.75 Sr 0.25 ) 0.95 MnO 3-δ /ScSZ cathode underwent an activation process during long-term testing, through which the charge transfer ability increased significantly. Meanwhile, low-frequency resistance (R L ) mainly attributed to the anode (80 %) significantly increased, probably due to the agglomeration of LSFNb particles. The LSFNb anode exhibits excellent anti-sulfuring poisoning ability and redox stability. These results demonstrate that LSFNb is a promising anode material for SOFCs. © 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Time to stability differences between male and female dancers after landing from a jump on flat and inclined floors.

PubMed

Pappas, Evangelos; Kremenic, Ian; Liederbach, Marijeanne; Orishimo, Karl F; Hagins, Marshall

2011-07-01

To determine the effect of gender and inclined floor on time to stability (TTS) after landing from a vertical jump. This study used a repeated measures design with male and female professional dancers landing on a flat and 4 inclined floors. A repeated measures univariate analysis of variance (gender × floor) was performed on TTS in the anterior-posterior and medial-lateral directions. Biomechanics laboratory. Twenty-three female and 13 male professional dancers. Gender and floor inclination (flat, posterior, anterior, lateral, and medial). Time to stability in the anterior-posterior and medial-lateral directions after landing from a vertical jump. Female dancers exhibited longer TTS in both directions (P ≤ 0.05). Floor inclination or the interaction of gender × floor did not have an effect on TTS (P > 0.3). Female dancers exhibited longer TTS after landing from a vertical jump compared with their male counterparts. This balance difference may be a factor related to the higher rate of ankle sprain among female dancers. Additionally, professional dancers exhibited similar TTS when landing on flat and inclined floors.

Enhanced aging properties of HKUST-1 in hydrophobic mixed-matrix membranes for ammonia adsorption.

PubMed

DeCoste, Jared B; Denny, Michael S; Peterson, Gregory W; Mahle, John J; Cohen, Seth M

2016-04-21

Metal-organic frameworks (MOFs) in their free powder form have exhibited superior capacities for many gases when compared to other materials, due to their tailorable functionality and high surface areas. Specifically, the MOF HKUST-1 binds small Lewis bases, such as ammonia, with its coordinatively unsaturated copper sites. We describe here the use of HKUST-1 in mixed-matrix membranes (MMMs) prepared from polyvinylidene difluoride (PVDF) for the removal of ammonia gas. These MMMs exhibit ammonia capacities similar to their hypothetical capacities based on the weight percent of HKUST-1 in each MMM. HKUST-1 in its powder form is unstable toward humid conditions; however, upon exposure to humid environments for prolonged periods of time, the HKUST-1 MMMs exhibit outstanding structural stability, and maintain their ammonia capacity. Overall, this study has achieved all of the critical and combined elements for real-world applications of MOFs: high MOF loadings, fully accessible MOF surfaces, enhanced MOF stabilization, recyclability, mechanical stability, and processability. This study is a critical step in advancing MOFs to a stable, usable, and enabling technology.

Post-Disturbance Stability of Fish Assemblages Measured at Coarse Taxonomic Resolution Masks Change at Finer Scales.

PubMed

Ceccarelli, Daniela M; Emslie, Michael J; Richards, Zoe T

2016-01-01

Quantifying changes to coral reef fish assemblages in the wake of cyclonic disturbances is challenging due to spatial variability of damage inherent in such events. Often, fish abundance appears stable at one spatial scale (e.g. reef-wide), but exhibits substantial change at finer scales (e.g. site-specific decline or increase). Taxonomic resolution also plays a role; overall stability at coarse taxonomic levels (e.g. family) may mask species-level turnover. Here we document changes to reef fish communities after severe Tropical Cyclone Ita crossed Lizard Island, Great Barrier Reef. Coral and reef fish surveys were conducted concurrently before and after the cyclone at four levels of exposure to the prevailing weather. Coral cover declined across all exposures except sheltered sites, with the largest decline at exposed sites. There was no significant overall reduction in the total density, biomass and species richness of reef fishes between 2011 and 2015, but individual fish taxa (families and species) changed in complex and unpredictable ways. For example, more families increased in density and biomass than decreased following Cyclone Ita, particularly at exposed sites whilst more fish families declined at lagoon sites even though coral cover did not decline. All sites lost biomass of several damselfish species, and at most sites there was an increase in macroinvertivores and grazers. Overall, these results suggest that the degree of change measured at coarse taxonomic levels masked high species-level turnover, although other potential explanations include that there was no impact of the storm, fish assemblages were impacted but underwent rapid recovery or that there is a time lag before the full impacts become apparent. This study confirms that in high-complexity, high diversity ecosystems such as coral reefs, species level analyses are essential to adequately capture the consequences of disturbance events.

Post-Disturbance Stability of Fish Assemblages Measured at Coarse Taxonomic Resolution Masks Change at Finer Scales

PubMed Central

Ceccarelli, Daniela M.

2016-01-01

Quantifying changes to coral reef fish assemblages in the wake of cyclonic disturbances is challenging due to spatial variability of damage inherent in such events. Often, fish abundance appears stable at one spatial scale (e.g. reef-wide), but exhibits substantial change at finer scales (e.g. site-specific decline or increase). Taxonomic resolution also plays a role; overall stability at coarse taxonomic levels (e.g. family) may mask species-level turnover. Here we document changes to reef fish communities after severe Tropical Cyclone Ita crossed Lizard Island, Great Barrier Reef. Coral and reef fish surveys were conducted concurrently before and after the cyclone at four levels of exposure to the prevailing weather. Coral cover declined across all exposures except sheltered sites, with the largest decline at exposed sites. There was no significant overall reduction in the total density, biomass and species richness of reef fishes between 2011 and 2015, but individual fish taxa (families and species) changed in complex and unpredictable ways. For example, more families increased in density and biomass than decreased following Cyclone Ita, particularly at exposed sites whilst more fish families declined at lagoon sites even though coral cover did not decline. All sites lost biomass of several damselfish species, and at most sites there was an increase in macroinvertivores and grazers. Overall, these results suggest that the degree of change measured at coarse taxonomic levels masked high species-level turnover, although other potential explanations include that there was no impact of the storm, fish assemblages were impacted but underwent rapid recovery or that there is a time lag before the full impacts become apparent. This study confirms that in high-complexity, high diversity ecosystems such as coral reefs, species level analyses are essential to adequately capture the consequences of disturbance events. PMID:27285160

New quantitative approaches reveal the spatial preference of nuclear compartments in mammalian fibroblasts.

PubMed

Weston, David J; Russell, Richard A; Batty, Elizabeth; Jensen, Kirsten; Stephens, David A; Adams, Niall M; Freemont, Paul S

2015-03-06

The nuclei of higher eukaryotic cells display compartmentalization and certain nuclear compartments have been shown to follow a degree of spatial organization. To date, the study of nuclear organization has often involved simple quantitative procedures that struggle with both the irregularity of the nuclear boundary and the problem of handling replicate images. Such studies typically focus on inter-object distance, rather than spatial location within the nucleus. The concern of this paper is the spatial preference of nuclear compartments, for which we have developed statistical tools to quantitatively study and explore nuclear organization. These tools combine replicate images to generate 'aggregate maps' which represent the spatial preferences of nuclear compartments. We present two examples of different compartments in mammalian fibroblasts (WI-38 and MRC-5) that demonstrate new knowledge of spatial preference within the cell nucleus. Specifically, the spatial preference of RNA polymerase II is preserved across normal and immortalized cells, whereas PML nuclear bodies exhibit a change in spatial preference from avoiding the centre in normal cells to exhibiting a preference for the centre in immortalized cells. In addition, we show that SC35 splicing speckles are excluded from the nuclear boundary and localize throughout the nucleoplasm and in the interchromatin space in non-transformed WI-38 cells. This new methodology is thus able to reveal the effect of large-scale perturbation on spatial architecture and preferences that would not be obvious from single cell imaging.

An unsupervised two-stage clustering approach for forest structure classification based on X-band InSAR data - A case study in complex temperate forest stands

NASA Astrophysics Data System (ADS)

Abdullahi, Sahra; Schardt, Mathias; Pretzsch, Hans

2017-05-01

Forest structure at stand level plays a key role for sustainable forest management, since the biodiversity, productivity, growth and stability of the forest can be positively influenced by managing its structural diversity. In contrast to field-based measurements, remote sensing techniques offer a cost-efficient opportunity to collect area-wide information about forest stand structure with high spatial and temporal resolution. Especially Interferometric Synthetic Aperture Radar (InSAR), which facilitates worldwide acquisition of 3d information independent from weather conditions and illumination, is convenient to capture forest stand structure. This study purposes an unsupervised two-stage clustering approach for forest structure classification based on height information derived from interferometric X-band SAR data which was performed in complex temperate forest stands of Traunstein forest (South Germany). In particular, a four dimensional input data set composed of first-order height statistics was non-linearly projected on a two-dimensional Self-Organizing Map, spatially ordered according to similarity (based on the Euclidean distance) in the first stage and classified using the k-means algorithm in the second stage. The study demonstrated that X-band InSAR data exhibits considerable capabilities for forest structure classification. Moreover, the unsupervised classification approach achieved meaningful and reasonable results by means of comparison to aerial imagery and LiDAR data.

CMAQ MODELING FOR AIR TOXICS AT FINE SCALES: A PROTOTYPE STUDY

EPA Science Inventory

Toxic air pollutants (TAPs) or hazardous air pollutants (HAPs) exhibit considerable spatial and temporal variability across urban areas. Therefore, the ability of chemical transport models (CTMs), e.g. Community Multi-scale Air Quality (CMAQ), to reproduce the spatial and tempor...

Protection Enhances Community and Habitat Stability: Evidence from a Mediterranean Marine Protected Area

PubMed Central

Fraschetti, Simonetta; Guarnieri, Giuseppe; Bevilacqua, Stanislao; Terlizzi, Antonio; Boero, Ferdinando

2013-01-01

Rare evidences support that Marine Protected Areas (MPAs) enhance the stability of marine habitats and assemblages. Based on nine years of observation (2001–2009) inside and outside a well managed MPA, we assessed the potential of conservation and management actions to modify patterns of spatial and/or temporal variability of Posidonia oceanica meadows, the lower midlittoral and the shallow infralittoral rock assemblages. Significant differences in both temporal variations and spatial patterns were observed between protected and unprotected locations. A lower temporal variability in the protected vs. unprotected assemblages was found in the shallow infralittoral, demonstrating that, at least at local scale, protection can enhance community stability. Macrobenthos with long-lived and relatively slow-growing invertebrates and structurally complex algal forms were homogeneously distributed in space and went through little fluctuations in time. In contrast, a mosaic of disturbed patches featured unprotected locations, with small-scale shifts from macroalgal stands to barrens, and harsh temporal variations between the two states. Opposite patterns of spatial and temporal variability were found for the midlittoral assemblages. Despite an overall clear pattern of seagrass regression through time, protected meadows showed a significantly higher shoot density than unprotected ones, suggesting a higher resistance to local human activities. Our results support the assumption that the exclusion/management of human activities within MPAs enhance the stability of the structural components of protected marine systems, reverting or arresting threat-induced trajectories of change. PMID:24349135

Effect of heat release on the spatial stability of a supersonic reacting mixing layer

NASA Technical Reports Server (NTRS)

Jackson, T. L.; Grosch, C. E.

1988-01-01

A numerical study of the stability of compressible mixing layers in which a diffusion flame is embedded is described. The mean velocity profile has been approximated by a hyperbolic tangent profile and the limit of infinite activation energy taken, which reduces the diffusion flame to a flame sheet. The addition of combustion in the form of a flame sheet was found to have important, and complex, effects on the flow stability.

Cytokinin stabilizes WUSCHEL by acting on the protein domains required for nuclear enrichment and transcription.

PubMed

Snipes, Stephen A; Rodriguez, Kevin; DeVries, Aaron E; Miyawaki, Kaori N; Perales, Mariano; Xie, Mingtang; Reddy, G Venugopala

2018-04-01

Concentration-dependent transcriptional regulation and the spatial regulation of transcription factor levels are poorly studied in plant development. WUSCHEL, a stem cell-promoting homeodomain transcription factor, accumulates at a higher level in the rib meristem than in the overlying central zone, which harbors stem cells in the shoot apical meristems of Arabidopsis thaliana. The differential accumulation of WUSCHEL in adjacent cells is critical for the spatial regulation and levels of CLAVATA3, a negative regulator of WUSCHEL transcription. Earlier studies have revealed that DNA-dependent dimerization, subcellular partitioning and protein destabilization control WUSCHEL protein levels and spatial accumulation. Moreover, the destabilization of WUSCHEL may also depend on the protein concentration. However, the roles of extrinsic spatial cues in maintaining differential accumulation of WUS are not understood. Through transient manipulation of hormone levels, hormone response patterns and analysis of the receptor mutants, we show that cytokinin signaling in the rib meristem acts through the transcriptional regulatory domains, the acidic domain and the WUSCHEL-box, to stabilize the WUS protein. Furthermore, we show that the same WUSCHEL-box functions as a degron sequence in cytokinin deficient regions in the central zone, leading to the destabilization of WUSCHEL. The coupled functions of the WUSCHEL-box in nuclear retention as described earlier, together with cytokinin sensing, reinforce higher nuclear accumulation of WUSCHEL in the rib meristem. In contrast a sub-threshold level may expose the WUSCHEL-box to destabilizing signals in the central zone. Thus, the cytokinin signaling acts as an asymmetric spatial cue in stabilizing the WUSCHEL protein to lead to its differential accumulation in neighboring cells, which is critical for concentration-dependent spatial regulation of CLAVATA3 transcription and meristem maintenance. Furthermore, our work shows that cytokinin response is regulated independently of the WUSCHEL function which may provide robustness to the regulation of WUSCHEL concentration.

Role of anisotropy in determining stability of electrodeposition at solid-solid interfaces

NASA Astrophysics Data System (ADS)

Ahmad, Zeeshan; Viswanathan, Venkatasubramanian

2017-10-01

We investigate the stability of electrodeposition at solid-solid interfaces for materials exhibiting an anisotropic mechanical response. The stability of electrodeposition or resistance to the formation of dendrites is studied within a linear stability analysis. The deformation and stress equations are solved using the Stroh formalism and faithfully recover the boundary conditions at the interface. The stability parameter is used to quantify the stability of different solid-solid interfaces incorporating the full anisotropy of the elastic tensor of the two materials. Results show a high degree of variability in the stability parameter depending on the crystallographic orientation of the solids in contact, and point to opportunities for exploiting this effect in developing Li metal anodes.

Accuration of Time Series and Spatial Interpolation Method for Prediction of Precipitation Distribution on the Geographical Information System

NASA Astrophysics Data System (ADS)

Prasetyo, S. Y. J.; Hartomo, K. D.

2018-01-01

The Spatial Plan of the Province of Central Java 2009-2029 identifies that most regencies or cities in Central Java Province are very vulnerable to landslide disaster. The data are also supported by other data from Indonesian Disaster Risk Index (In Indonesia called Indeks Risiko Bencana Indonesia) 2013 that suggest that some areas in Central Java Province exhibit a high risk of natural disasters. This research aims to develop an application architecture and analysis methodology in GIS to predict and to map rainfall distribution. We propose our GIS architectural application of “Multiplatform Architectural Spatiotemporal” and data analysis methods of “Triple Exponential Smoothing” and “Spatial Interpolation” as our significant scientific contribution. This research consists of 2 (two) parts, namely attribute data prediction using TES method and spatial data prediction using Inverse Distance Weight (IDW) method. We conduct our research in 19 subdistricts in the Boyolali Regency, Central Java Province, Indonesia. Our main research data is the biweekly rainfall data in 2000-2016 Climatology, Meteorology, and Geophysics Agency (In Indonesia called Badan Meteorologi, Klimatologi, dan Geofisika) of Central Java Province and Laboratory of Plant Disease Observations Region V Surakarta, Central Java. The application architecture and analytical methodology of “Multiplatform Architectural Spatiotemporal” and spatial data analysis methodology of “Triple Exponential Smoothing” and “Spatial Interpolation” can be developed as a GIS application framework of rainfall distribution for various applied fields. The comparison between the TES and IDW methods show that relative to time series prediction, spatial interpolation exhibit values that are approaching actual. Spatial interpolation is closer to actual data because computed values are the rainfall data of the nearest location or the neighbour of sample values. However, the IDW’s main weakness is that some area might exhibit the rainfall value of 0. The representation of 0 in the spatial interpolation is mainly caused by the absence of rainfall data in the nearest sample point or too far distance that produces smaller weight.

Support vector machine in crash prediction at the level of traffic analysis zones: Assessing the spatial proximity effects.

PubMed

Dong, Ni; Huang, Helai; Zheng, Liang

2015-09-01

In zone-level crash prediction, accounting for spatial dependence has become an extensively studied topic. This study proposes Support Vector Machine (SVM) model to address complex, large and multi-dimensional spatial data in crash prediction. Correlation-based Feature Selector (CFS) was applied to evaluate candidate factors possibly related to zonal crash frequency in handling high-dimension spatial data. To demonstrate the proposed approaches and to compare them with the Bayesian spatial model with conditional autoregressive prior (i.e., CAR), a dataset in Hillsborough county of Florida was employed. The results showed that SVM models accounting for spatial proximity outperform the non-spatial model in terms of model fitting and predictive performance, which indicates the reasonableness of considering cross-zonal spatial correlations. The best model predictive capability, relatively, is associated with the model considering proximity of the centroid distance by choosing the RBF kernel and setting the 10% of the whole dataset as the testing data, which further exhibits SVM models' capacity for addressing comparatively complex spatial data in regional crash prediction modeling. Moreover, SVM models exhibit the better goodness-of-fit compared with CAR models when utilizing the whole dataset as the samples. A sensitivity analysis of the centroid-distance-based spatial SVM models was conducted to capture the impacts of explanatory variables on the mean predicted probabilities for crash occurrence. While the results conform to the coefficient estimation in the CAR models, which supports the employment of the SVM model as an alternative in regional safety modeling. Copyright © 2015 Elsevier Ltd. All rights reserved.

Stabilization of posture by precision touch of the index finger with rigid and flexible filaments

NASA Technical Reports Server (NTRS)

Lackner, J. R.; Rabin, E.; DiZio, P.

2001-01-01

Light touch of the index finger with a stationary surface at non-mechanically supportive force levels (<100 g) greatly attenuates the body sway of standing subjects. In three experiments, we evaluated the properties of finger contact and of the contacted object necessary to produce postural stabilization in subjects standing heel-to-toe with eyes closed, as well as how accurately hand position can be controlled. Experiment 1 involved finger contact with flexible filaments of different bending strengths, a flat surface, and an imagined spatial position. Contact with the flat surface was most effective in attenuating sway; the flexible filaments were much less effective but still significantly better than imagined contact. Experiment 2 compared the effectiveness of finger contact with a flexible filament, a rigid filament of the same diameter, a flat surface, and an imagined spatial position. The rigid filament and flat surface conditions were equally effective in attenuating body sway and were greatly superior to contact with the flexible filament, which was superior to imagined contact. Experiment 3 included five conditions: arms by sides; finger "contact" with an imagined spatial position; finger contact with a flat surface; finger contact with a flexible filament attempting to maintain it bent; and contact with the flexible filament attempting not to bend it. The arms by sides and finger "contact" with an imagined position conditions did not differ significantly; all three conditions involving actual finger contact showed significantly less center of pressure and hand sway, but contact with the flat surface was most effective in attenuating both postural and hand displacement. In all three experiments, the level of force applied in fingertip contact conditions was far below that necessary to provide mechanical stabilization. Our findings indicate that: (1) stimulation of a small number of receptors in the fingertip is adequate to allow stabilization of sway, (2) fingertip force levels as low as 5-10 g provide some stabilization, (3) contact with a stationary spatial referent is most effective, and (4) independent control of arm and torso occurs when finger contact is allowed.

Effects of site-directed mutagenesis of Asn116 in the β-hairpin of the N-terminal domain of thermolysin on its activity and stability.

PubMed

Menach, Evans; Yasukawa, Kiyoshi; Inouye, Kuniyo

2012-09-01

In the N-terminal domain of thermolysin, two anti-parallel β-strands, Asn112-Ala113-Phe114-Trp115 and Ser118-Gln119-Met120-Val121-Tyr122 are connected by an Asn116-Gly117 turn to form a β-hairpin structure. In this study, we examined the role of Asn116 in the activity and stability of thermolysin by site-directed mutagenesis. Of the 19 Asn116 variants, four (N116A, N116D, N116T and N116Q) were produced in Escherichia coli, by co-expressing the mature and pro domains separately, while the other 15 were not. In the hydrolysis of N-[3-(2-furyl)acryloyl]-glycyl-L-leucine amide (FAGLA) at 25°C, the intrinsic k(cat)/K(m) value of N116D was 320% of that of the wild-type thermolysin (WT), and in the hydrolysis of N-carbobenzoxy-L-aspartyl-L-phenylalanine methyl ester (ZDFM) at pH 7.5 at 25°C, the k(cat)/K(m) value of N116D was 140% of that of WT, indicating that N116D exhibited higher activity than WT. N116Q exhibited similar activity as WT, and N116A and N116T exhibited reduced activities. The first-order rate constants, k(obs), of the thermal inactivation at 80°C were in the order N116A, N116D, N116T > N116Q > WT at all CaCl(2) concentrations examined (1-100 mM), indicating that all variants exhibited reduced stabilities. These results suggest that Asn116 plays an important role in the activity and stability of thermolysin presumably by stabilizing this β-hairpin structure.

Regional Population Dynamics

Treesearch

Andrew Birt

2011-01-01

The population dynamics of the southern pine beetle (SPB) exhibit characteristic fluctuations between relatively long endemic and shorter outbreak periods. Populations exhibit complex and hierarchical spatial structure with beetles and larvae aggregating within individual trees, infestations with multiple infested trees, and regional outbreaks that comprise a large...

Understanding the Spatio-Temporal Response of Coral Reef Fish Communities to Natural Disturbances: Insights from Beta-Diversity Decomposition

PubMed Central

Lamy, Thomas; Legendre, Pierre; Chancerelle, Yannick; Siu, Gilles; Claudet, Joachim

2015-01-01

Understanding how communities respond to natural disturbances is fundamental to assess the mechanisms of ecosystem resistance and resilience. However, ecosystem responses to natural disturbances are rarely monitored both through space and time, while the factors promoting ecosystem stability act at various temporal and spatial scales. Hence, assessing both the spatial and temporal variations in species composition is important to comprehensively explore the effects of natural disturbances. Here, we suggest a framework to better scrutinize the mechanisms underlying community responses to disturbances through both time and space. Our analytical approach is based on beta diversity decomposition into two components, replacement and biomass difference. We illustrate this approach using a 9-year monitoring of coral reef fish communities off Moorea Island (French Polynesia), which encompassed two severe natural disturbances: a crown-of-thorns starfish outbreak and a hurricane. These disturbances triggered a fast logistic decline in coral cover, which suffered a 90% decrease on all reefs. However, we found that the coral reef fish composition remained largely stable through time and space whereas compensatory changes in biomass among species were responsible for most of the temporal fluctuations, as outlined by the overall high contribution of the replacement component to total beta diversity. This suggests that, despite the severity of the two disturbances, fish communities exhibited high resistance and the ability to reorganize their compositions to maintain the same level of total community biomass as before the disturbances. We further investigated the spatial congruence of this pattern and showed that temporal dynamics involved different species across sites; yet, herbivores controlling the proliferation of algae that compete with coral communities were consistently favored. These results suggest that compensatory changes in biomass among species and spatial heterogeneity in species responses can provide further insurance against natural disturbances in coral reef ecosystems by promoting high levels of key species (herbivores). They can also allow the ecosystem to recover more quickly. PMID:26393511

Understanding the Spatio-Temporal Response of Coral Reef Fish Communities to Natural Disturbances: Insights from Beta-Diversity Decomposition.

PubMed

Lamy, Thomas; Legendre, Pierre; Chancerelle, Yannick; Siu, Gilles; Claudet, Joachim

2015-01-01

Understanding how communities respond to natural disturbances is fundamental to assess the mechanisms of ecosystem resistance and resilience. However, ecosystem responses to natural disturbances are rarely monitored both through space and time, while the factors promoting ecosystem stability act at various temporal and spatial scales. Hence, assessing both the spatial and temporal variations in species composition is important to comprehensively explore the effects of natural disturbances. Here, we suggest a framework to better scrutinize the mechanisms underlying community responses to disturbances through both time and space. Our analytical approach is based on beta diversity decomposition into two components, replacement and biomass difference. We illustrate this approach using a 9-year monitoring of coral reef fish communities off Moorea Island (French Polynesia), which encompassed two severe natural disturbances: a crown-of-thorns starfish outbreak and a hurricane. These disturbances triggered a fast logistic decline in coral cover, which suffered a 90% decrease on all reefs. However, we found that the coral reef fish composition remained largely stable through time and space whereas compensatory changes in biomass among species were responsible for most of the temporal fluctuations, as outlined by the overall high contribution of the replacement component to total beta diversity. This suggests that, despite the severity of the two disturbances, fish communities exhibited high resistance and the ability to reorganize their compositions to maintain the same level of total community biomass as before the disturbances. We further investigated the spatial congruence of this pattern and showed that temporal dynamics involved different species across sites; yet, herbivores controlling the proliferation of algae that compete with coral communities were consistently favored. These results suggest that compensatory changes in biomass among species and spatial heterogeneity in species responses can provide further insurance against natural disturbances in coral reef ecosystems by promoting high levels of key species (herbivores). They can also allow the ecosystem to recover more quickly.

Plasticity and stability of visual field maps in adult primary visual cortex

PubMed Central

Wandell, Brian A.; Smirnakis, Stelios M.

2010-01-01

Preface It is important to understand the balance between cortical plasticity and stability in various systems and spatial scales in the adult brain. We review measurements of adult plasticity in primary visual cortex (V1), a structure that has a key role in distributing visual information. There are claims of plasticity at multiple spatial scales in adult V1, but many inconsistencies in the data raise questions about the extent and nature of such plasticity. Understanding is further limited by a lack of quantitative models to guide the interpretation of the data. These problems limit efforts to translate research findings about adult cortical plasticity into significant clinical, educational and policy applications. PMID:19904279

Inter-subject FDG PET Brain Networks Exhibit Multi-scale Community Structure with Different Normalization Techniques.

PubMed

Sperry, Megan M; Kartha, Sonia; Granquist, Eric J; Winkelstein, Beth A

2018-07-01

Inter-subject networks are used to model correlations between brain regions and are particularly useful for metabolic imaging techniques, like 18F-2-deoxy-2-(18F)fluoro-D-glucose (FDG) positron emission tomography (PET). Since FDG PET typically produces a single image, correlations cannot be calculated over time. Little focus has been placed on the basic properties of inter-subject networks and if they are affected by group size and image normalization. FDG PET images were acquired from rats (n = 18), normalized by whole brain, visual cortex, or cerebellar FDG uptake, and used to construct correlation matrices. Group size effects on network stability were investigated by systematically adding rats and evaluating local network connectivity (node strength and clustering coefficient). Modularity and community structure were also evaluated in the differently normalized networks to assess meso-scale network relationships. Local network properties are stable regardless of normalization region for groups of at least 10. Whole brain-normalized networks are more modular than visual cortex- or cerebellum-normalized network (p < 0.00001); however, community structure is similar at network resolutions where modularity differs most between brain and randomized networks. Hierarchical analysis reveals consistent modules at different scales and clustering of spatially-proximate brain regions. Findings suggest inter-subject FDG PET networks are stable for reasonable group sizes and exhibit multi-scale modularity.

Investigating local controls on temporal stability of soil water content using sensor network data and an inverse modeling approach

NASA Astrophysics Data System (ADS)

Qu, W.; Bogena, H. R.; Huisman, J. A.; Martinez, G.; Pachepsky, Y. A.; Vereecken, H.

2013-12-01

Soil water content is a key variable in the soil, vegetation and atmosphere continuum with high spatial and temporal variability. Temporal stability of soil water content (SWC) has been observed in multiple monitoring studies and the quantification of controls on soil moisture variability and temporal stability presents substantial interest. The objective of this work was to assess the effect of soil hydraulic parameters on the temporal stability. The inverse modeling based on large observed time series SWC with in-situ sensor network was used to estimate the van Genuchten-Mualem (VGM) soil hydraulic parameters in a small grassland catchment located in western Germany. For the inverse modeling, the shuffled complex evaluation (SCE) optimization algorithm was coupled with the HYDRUS 1D code. We considered two cases: without and with prior information about the correlation between VGM parameters. The temporal stability of observed SWC was well pronounced at all observation depths. Both the spatial variability of SWC and the robustness of temporal stability increased with depth. Calibrated models both with and without prior information provided reasonable correspondence between simulated and measured time series of SWC. Furthermore, we found a linear relationship between the mean relative difference (MRD) of SWC and the saturated SWC (θs). Also, the logarithm of saturated hydraulic conductivity (Ks), the VGM parameter n and logarithm of α were strongly correlated with the MRD of saturation degree for the prior information case, but no correlation was found for the non-prior information case except at the 50cm depth. Based on these results we propose that establishing relationships between temporal stability and spatial variability of soil properties presents a promising research avenue for a better understanding of the controls on soil moisture variability. Correlation between Mean Relative Difference of soil water content (or saturation degree) and inversely estimated soil hydraulic parameters (log10(Ks), log10(α), n, and θs) at 5-cm, 20-cm and 50-cm depths. Solid circles represent parameters estimated by using prior information; open circles represent parameters estimated without using prior information.

Freeze-dried snake antivenoms formulated with sorbitol, sucrose or mannitol: comparison of their stability in an accelerated test.

PubMed

Herrera, María; Tattini, Virgilio; Pitombo, Ronaldo N M; Gutiérrez, José María; Borgognoni, Camila; Vega-Baudrit, José; Solera, Federico; Cerdas, Maykel; Segura, Alvaro; Villalta, Mauren; Vargas, Mariángela; León, Guillermo

2014-11-01

Freeze-drying is used to improve the long term stability of pharmaceutical proteins. Sugars and polyols have been successfully used in the stabilization of proteins. However, their use in the development of freeze-dried antivenoms has not been documented. In this work, whole IgG snake antivenom, purified from equine plasma, was formulated with different concentrations of sorbitol, sucrose or mannitol. The glass transition temperatures of frozen formulations, determined by Differential Scanning Calorimetry (DSC), ranged between -13.5 °C and -41 °C. In order to evaluate the effectiveness of the different stabilizers, the freeze-dried samples were subjected to an accelerated stability test at 40 ± 2 °C and 75 ± 5% relative humidity. After six months of storage at 40 °C, all the formulations presented the same residual humidity, but significant differences were observed in turbidity, reconstitution time and electrophoretic pattern. Moreover, all formulations, except antivenoms freeze-dried with mannitol, exhibited the same potency for the neutralization of lethal effect of Bothrops asper venom. The 5% (w:v) sucrose formulation exhibited the best stability among the samples tested, while mannitol and sorbitol formulations turned brown. These results suggest that sucrose is a better stabilizer than mannitol and sorbitol in the formulation of freeze-dried antivenoms under the studied conditions. Copyright © 2014 Elsevier Ltd. All rights reserved.

Structural and Functional Analysis of an mRNP Complex That Mediates the High Stability of Human β-Globin mRNA

PubMed Central

Yu, Jia; Russell, J. Eric

2001-01-01

Human globins are encoded by mRNAs exhibiting high stabilities in transcriptionally silenced erythrocyte progenitors. Unlike α-globin mRNA, whose stability is enhanced by assembly of a specific messenger RNP (mRNP) α complex on its 3′ untranslated region (UTR), neither the structure(s) nor the mechanism(s) that effects the high-level stability of human β-globin mRNA has been identified. The present work describes an mRNP complex assembling on the 3′ UTR of the β-globin mRNA that exhibits many of the properties of the stability-enhancing α complex. The β-globin mRNP complex is shown to contain one or more factors homologous to αCP, a 39-kDa RNA-binding protein that is integral to α-complex assembly. Sequence analysis implicates a specific 14-nucleotide pyrimidine-rich track within its 3′ UTR as the site of β-globin mRNP assembly. The importance of this track to mRNA stability is subsequently verified in vivo using mice expressing human β-globin transgenes that contain informative mutations in this region. In combination, the in vitro and in vivo analyses indicate that the high stabilities of the α- and β-globin mRNAs are maintained through related mRNP complexes that may share a common regulatory pathway. PMID:11486027

A field-validated model for in situ transport of polymer-stabilized nZVI and implications for subsurface injection.

PubMed

Krol, Magdalena M; Oleniuk, Andrew J; Kocur, Chris M; Sleep, Brent E; Bennett, Peter; Xiong, Zhong; O'Carroll, Denis M

2013-07-02

Nanoscale zerovalent iron (nZVI) particles have significant potential to remediate contaminated source zones. However, the transport of these particles through porous media is not well understood, especially at the field scale. This paper describes the simulation of a field injection of carboxylmethyl cellulose (CMC) stabilized nZVI using a 3D compositional simulator, modified to include colloidal filtration theory (CFT). The model includes composition dependent viscosity and spatially and temporally variable velocity, appropriate for the simulation of push-pull tests (PPTs) with CMC stabilized nZVI. Using only attachment efficiency as a fitting parameter, model results were in good agreement with field observations when spatially variable viscosity effects on collision efficiency were included in the transport modeling. This implies that CFT-modified transport equations can be used to simulate stabilized nZVI field transport. Model results show that an increase in solution viscosity, resulting from injection of CMC stabilized nZVI suspension, affects nZVI mobility by decreasing attachment as well as changing the hydraulics of the system. This effect is especially noticeable with intermittent pumping during PPTs. Results from this study suggest that careful consideration of nZVI suspension formulation is important for optimal delivery of nZVI which can be facilitated with the use of a compositional simulator.

Global stability behaviour for the BEK family of rotating boundary layers

NASA Astrophysics Data System (ADS)

Davies, Christopher; Thomas, Christian

2017-12-01

Numerical simulations were conducted to investigate the linear global stability behaviour of the Bödewadt, Ekman, von Kármán (BEK) family of flows, for cases where a disc rotates beneath an incompressible fluid that is also rotating. This extends the work reported in recent studies that only considered the rotating-disc boundary layer with a von Kármán configuration, where the fluid that lies above the boundary layer remains stationary. When a homogeneous flow approximation is made, neglecting the radial variation of the basic state, it can be shown that linearised disturbances are susceptible to absolute instability. We shall demonstrate that, despite this prediction of absolute instability, the disturbance development exhibits globally stable behaviour in the BEK boundary layers with a genuine radial inhomogeneity. For configurations where the disc rotation rate is greater than that of the overlying fluid, disturbances propagate radially outwards and there is only a convective form of instability. This replicates the behaviour that had previously been documented when the fluid did not rotate beyond the boundary layer. However, if the fluid rotation rate is taken to exceed that of the disc, then the propagation direction reverses and disturbances grow while convecting radially inwards. Eventually, as they approach regions of smaller radii, where stability is predicted according to the homogeneous flow approximation, the growth rates reduce until decay takes over. Given sufficient time, such disturbances can begin to diminish at every radial location, even those which are positioned outwards from the radius associated with the onset of absolute instability. This leads to the confinement of the disturbance development within a finitely bounded region of the spatial-temporal plane.

Supramolecular structure of the casein micelle.

PubMed

McMahon, D J; Oommen, B S

2008-05-01

The supramolecular structure of colloidal casein micelles in milk was investigated by using a sample preparation protocol based on adsorption of proteins onto a poly-l-lysine and parlodion-coated copper grid, staining of proteins and calcium phosphate by uranyl oxalate, instantaneous freezing, and drying under a high vacuum. High-resolution transmission electron microscopy stereo-images were obtained showing the interior structure of casein micelles. On the basis of our interpretation of these images, an interlocked lattice model was developed in which both casein-calcium phosphate aggregates and casein polymer chains act together to maintain casein micelle integrity. The caseins form linear and branched chains (2 to 5 proteins long) interlocked by the casein-stabilized calcium phosphate nanoclusters. This model suggests that stabilization of calcium phosphate nanoclusters by phosphoserine domains of alpha(s1)-, alpha(s2)-, or beta-casein, or their combination, would orient their hydrophobic domains outward, allowing interaction and binding to other casein molecules. Other interactions between the caseins, such as calcium bridging, could also occur and further stabilize the supramolecule. The combination of having an interlocked lattice structure and multiple interactions results in an open, sponge-like colloidal supramolecule that is resistant to spatial changes and disintegration. Hydrophobic interactions between caseins surrounding a calcium phosphate nanocluster would prevent complete dissociation of casein micelles when the calcium phosphate nanoclusters are solubilized. Likewise, calcium bridging and other electrostatic interactions between caseins would prevent dissociation of the casein micelles into casein-calcium phosphate nanocluster aggregates when milk is cooled or urea is added to milk, and hydrophobic interactions are reduced. The appearance of both polymer chains and small aggregate particles during milk synthesis would also be expected based on this interlocked lattice model of casein micelles, and its supramolecule structure thus exhibits the principles of self-aggregation, interdependence, and diversity observed in nature.

Differential effects of absent visual feedback control on gait variability during different locomotion speeds.

PubMed

Wuehr, M; Schniepp, R; Pradhan, C; Ilmberger, J; Strupp, M; Brandt, T; Jahn, K

2013-01-01

Healthy persons exhibit relatively small temporal and spatial gait variability when walking unimpeded. In contrast, patients with a sensory deficit (e.g., polyneuropathy) show an increased gait variability that depends on speed and is associated with an increased fall risk. The purpose of this study was to investigate the role of vision in gait stabilization by determining the effects of withdrawing visual information (eyes closed) on gait variability at different locomotion speeds. Ten healthy subjects (32.2 ± 7.9 years, 5 women) walked on a treadmill for 5-min periods at their preferred walking speed and at 20, 40, 70, and 80 % of maximal walking speed during the conditions of walking with eyes open (EO) and with eyes closed (EC). The coefficient of variation (CV) and fractal dimension (α) of the fluctuations in stride time, stride length, and base width were computed and analyzed. Withdrawing visual information increased the base width CV for all walking velocities (p < 0.001). The effects of absent visual information on CV and α of stride time and stride length were most pronounced during slow locomotion (p < 0.001) and declined during fast walking speeds. The results indicate that visual feedback control is used to stabilize the medio-lateral (i.e., base width) gait parameters at all speed sections. In contrast, sensory feedback control in the fore-aft direction (i.e., stride time and stride length) depends on speed. Sensory feedback contributes most to fore-aft gait stabilization during slow locomotion, whereas passive biomechanical mechanisms and an automated central pattern generation appear to control fast locomotion.

Biodiversity, productivity, and the spatial insurance hypothesis revisited

PubMed Central

Shanafelt, David W.; Dieckmann, Ulf; Jonas, Matthias; Franklin, Oskar; Loreau, Michel; Perrings, Charles

2015-01-01

Accelerating rates of biodiversity loss have led ecologists to explore the effects of species richness on ecosystem functioning and the flow of ecosystem services. One explanation of the relationship between biodiversity and ecosystem functioning lies in the spatial insurance hypothesis, which centers on the idea that productivity and stability increase with biodiversity in a temporally varying, spatially heterogeneous environment. However, there has been little work on the impact of dispersal where environmental risks are more or less spatially correlated, or where dispersal rates are variable. In this paper, we extend the original Loreau model to consider stochastic temporal variation in resource availability, which we refer to as “environmental risk,” and heterogeneity in species dispersal rates. We find that asynchronies across communities and species provide community-level stabilizing effects on productivity, despite varying levels of species richness. Although intermediate dispersal rates play a role in mitigating risk, they are less effective in insuring productivity against global (metacommunity-level) than local (individual community-level) risks. These results are particularly interesting given the emergence of global sources of risk such as climate change or the closer integration of world markets. Our results offer deeper insights into the Loreau model and new perspectives on the effectiveness of spatial insurance in the face of environmental risks. PMID:26100182

Biodiversity, productivity, and the spatial insurance hypothesis revisited.

PubMed

Shanafelt, David W; Dieckmann, Ulf; Jonas, Matthias; Franklin, Oskar; Loreau, Michel; Perrings, Charles

2015-09-07

Accelerating rates of biodiversity loss have led ecologists to explore the effects of species richness on ecosystem functioning and the flow of ecosystem services. One explanation of the relationship between biodiversity and ecosystem functioning lies in the spatial insurance hypothesis, which centers on the idea that productivity and stability increase with biodiversity in a temporally varying, spatially heterogeneous environment. However, there has been little work on the impact of dispersal where environmental risks are more or less spatially correlated, or where dispersal rates are variable. In this paper, we extend the original Loreau model to consider stochastic temporal variation in resource availability, which we refer to as "environmental risk", and heterogeneity in species dispersal rates. We find that asynchronies across communities and species provide community-level stabilizing effects on productivity, despite varying levels of species richness. Although intermediate dispersal rates play a role in mitigating risk, they are less effective in insuring productivity against global (metacommunity-level) than local (individual community-level) risks. These results are particularly interesting given the emergence of global sources of risk such as climate change or the closer integration of world markets. Our results offer deeper insights into the Loreau model and new perspectives on the effectiveness of spatial insurance in the face of environmental risks. Copyright © 2015 Elsevier Ltd. All rights reserved.

Portable Oxygen Generation for Medical Applications.

DTIC Science & Technology

1997-07-01

stabilized zirconia; these include scandia- stabilized zirconia, lanthanum gallate , ceria, and bismuth oxide. Scandia-stabilized zirconia [1] exhibits...uncertainty of using doped ceria is its high thermal expansion coefficient (ceria -13-14 ppm/°C, YSZ -10.5 ppm/°C). Lanthanum gallate (LaGa03) [2-4...the conductivity of lanthanum gallate approximately 2-3 times that of YSZ in the 600- 1000°C temperature range. The enhanced conductivity in lanthanum

Semiconducting compounds and devices incorporating same

DOEpatents

Marks, Tobin J; Facchetti, Antonio; Boudreault, Pierre-Luc; Miyauchi, Hiroyuki

2014-06-17

Disclosed are molecular and polymeric compounds having desirable properties as semiconducting materials. Such compounds can exhibit desirable electronic properties and possess processing advantages including solution-processability and/or good stability. Organic transistor and photovoltaic devices incorporating the present compounds as the active layer exhibit good device performance.

Semiconducting compounds and devices incorporating same

DOEpatents

Marks, Tobin J.; Facchetti, Antonio; Boudreault, Pierre-Luc; Miyauchi, Hiroyuki

2016-01-19

Disclosed are molecular and polymeric compounds having desirable properties as semiconducting materials. Such compounds can exhibit desirable electronic properties and possess processing advantages including solution-processability and/or good stability. Organic transistor and photovoltaic devices incorporating the present compounds as the active layer exhibit good device performance.

Improved control of multiple-antibiotic-resistance-related microbial risk in swine manure wastes by autothermal thermophilic aerobic digestion.

PubMed

Han, Il; Congeevaram, Shankar; Park, Joonhong

2009-01-01

In this study, we microbiologically evaluated antibiotic resistance and pathogenicity in livestock (swine) manure as well as its biologically stabilized products. One of new livestock manure stabilization techniques is ATAD (Autothermal Thermophilic Aerobic Digestion). Because of its high operation temperature (60-65 degrees C), it has been speculated to have effective microbial risk control in livestock manure. This hypothesis was tested by evaluating microbial risk in ATAD-treated swine manure. Antibiotic resistance, multiple antibiotic resistance (MAR), and pathogenicity were microbiologically examined for swine manure as well as its conventionally stabilized (anaerobically fermented) and ATAD-stabilized products. In the swine manure and its conventionally stabilized product, antibiotic resistant (tetracycline-, kanamycine-, ampicillin-, and rifampicin-resistant) bacteria and the pathogen indicator bacteria were detected. Furthermore, approximately 2-5% of the Staphylococcus and Salmonella colonies from their selective culture media were found to exhibit a MAR-phenotypes, suggesting a serious level of microbe induced health risk. In contrast, after the swine manure was stabilized with a pilot-scale ATAD treatment for 3 days at 60-65 degrees C, antibiotic resistant bacteria, pathogen indicator bacteria, and MAR-exhibiting pathogens were all undetected. These findings support the improved control of microbial risk in livestock wastes by ATAD treatment.

Satellites and Human Health: Potential for Tracking Cholera Outbreaks

NASA Astrophysics Data System (ADS)

Jutla, A. S.; Akanda, A. S.; Islam, S.

2009-12-01

Cholera continues to be a significant health threat across the globe. The pattern and magnitude of the seven global pandemics suggest that cholera outbreaks primarily originate in coastal regions and spread inland through secondary means. Cholera bacteria show strong association with zooplankton and phytoplankton abundance in coastal ecosystems. Characterization of space-time variability of chlorophyll, a surrogate for phytoplankton abundance, in Northern Bay of Bengal (BoB) is an essential step to develop any methodology for tracking cholera in the Bengal Delta from space. Using ten years of satellite data, this study (a) quantifies the space-time distribution of chlorophyll in BoB region and (b) presents a hypothesis as to how coastal plankton may be related with cholera outbreaks. Preliminary results suggest that variability of chlorophyll at daily scale, irrespective of spatial averaging, resembles white noise. At a monthly scale, chlorophyll shows distinct annual seasonality and chlorophyll values are significantly higher close to the coast than those in the offshore regions. At pixel level (9 km) on monthly scale, on the other hand, chlorophyll does not exhibit much persistence in time. With increased spatial averaging, temporal persistence of monthly chlorophyll increases and lag one autocorrelation stabilizes around 0.60 for 1200 km2 or larger areal averages. Spatial analyses of chlorophyll suggest that coastal region in BoB have a stable sill at 100 km range. Using satellite chlorophyll data, we observe that phytoplankton blooms occur every year in BoB, yet severe cholera outbreaks happen in certain years. This study provides a working hypothesis on how BoB coastal plankton blooms aided by regional hydroclimatic processes may lead to possible cholera outbreaks in Bengal Delta.

Evaluating a process-based model for use in streambank stabilization and stream restoration: insights on the bank stability and toe erosion model (BSTEM)

USDA-ARS?s Scientific Manuscript database

Streambank retreat is a complex cyclical process involving subaerial processes, fluvial erosion, seepage erosion, and geotechnical failures and is driven by several soil properties that themselves are temporally and spatially variable. Therefore, it can be extremely challenging to predict and model ...

In silico selection of expression reference genes with demonstrated stability in barley among a diverse set of tissues and cultivars

USDA-ARS?s Scientific Manuscript database

Premise of the study: Reference genes are selected based on the assumption of temporal and spatial expression stability and on their widespread use in model species. They are often used in new target species without validation, presumed as stable. For barley, reference gene validation is lacking, bu...

Spatial Patterns of Inshore Marine Soundscapes.

PubMed

McWilliam, Jamie

2016-01-01

Passive acoustic monitoring was employed to investigate spatial patterns of soundscapes within a marine reserve. High energy level broadband snaps dominated nearly all habitat soundscapes. Snaps, the principal acoustic feature of soundscapes, were primarily responsible for the observed spatial patterns, and soundscapes appeared to retain a level of compositional and configurational stability. In the presence of high-level broadband snaps, soundscape composition was more influenced by geographic location than habitat type. Future research should focus on investigating the spatial patterns of soundscapes across a wider range of coastal and offshore seascapes containing a variety of distinct ecosystems and habitats.

Abstention in dynamical models of spatial voting

NASA Astrophysics Data System (ADS)

Stadler, B. M. R.

2000-12-01

We consider a model of platform adaptation in spatial voting focussing on the effect of abstention on the stability of the mean voter equilibrium. Two distinct approaches for modeling abstention are explored: (1) voters abstain if party platforms are very much similar to each other and (2) voters abstain if both party platforms are far away from their ideal points.

Spatial Working Memory Capacity Predicts Bias in Estimates of Location

ERIC Educational Resources Information Center

Crawford, L. Elizabeth; Landy, David; Salthouse, Timothy A.

2016-01-01

Spatial memory research has attributed systematic bias in location estimates to a combination of a noisy memory trace with a prior structure that people impose on the space. Little is known about intraindividual stability and interindividual variation in these patterns of bias. In the current work, we align recent empirical and theoretical work on…

Spatial complementarity of forests and farms: accounting for ecosystem services

Treesearch

Subhrendu K. Pattanayak; David T. Butry

2006-01-01

Our article considers the economic contributions of forest ecosystem services, using a case study from Flores, Indonesia, in which forest protection in upstream watersheds stabilize soil and hydrological flows in downstream farms. We focus on the demand for a weak complement to the ecosystem services--farm labor-- and account for spatial dependence due to economic...

Enhanced planar perovskite solar cell efficiency and stability using a perovskite/PCBM heterojunction formed in one step.

PubMed

Zhou, Long; Chang, Jingjing; Liu, Ziye; Sun, Xu; Lin, Zhenhua; Chen, Dazheng; Zhang, Chunfu; Zhang, Jincheng; Hao, Yue

2018-02-08

Perovskite/PCBM heterojunctions are efficient for fabricating perovskite solar cells with high performance and long-term stability. In this study, an efficient perovskite/PCBM heterojunction was formed via conventional sequential deposition and one-step formation processes. Compared with conventional deposition, the one-step process was more facile, and produced a perovskite thin film of substantially improved quality due to fullerene passivation. Moreover, the resulting perovskite/PCBM heterojunction exhibited more efficient carrier transfer and extraction, and reduced carrier recombination. The perovskite solar cell device based on one-step perovskite/PCBM heterojunction formation exhibited a higher maximum PCE of 17.8% compared with that from the conventional method (13.7%). The device also showed exceptional stability, retaining 83% of initial PCE after 60 days of storage under ambient conditions.

Effect of preparation methods on dispersion stability and electrochemical performance of graphene sheets

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chen, Li, E-mail: chenli1981@lut.cn; Li, Na; Zhang, Mingxia

Chemical exfoliation is one of the most important strategies for preparing graphene. The aggregation of graphene sheets severely prevents graphene from exhibiting excellent properties. However, there are no attempts to investigate the effect of preparation methods on the dispersity of graphene sheets. In this study, three chemical exfoliation methods, including Hummers method, modified Hummers method, and improved method, were used to prepare graphene sheets. The influence of preparation methods on the structure, dispersion stability in organic solvents, and electrochemical properties of graphene sheets were investigated. Fourier transform infrared microscopy, Raman spectra, transmission electron microscopy, and UV–vis spectrophotometry were employed tomore » analyze the structure of the as-prepared graphene sheets. The results showed that graphene prepared by improved method exhibits excellent dispersity and stability in organic solvents without any additional stabilizer or modifier, which is attributed to the completely exfoliation and regular structure. Moreover, cyclic voltammetric and electrochemical impedance spectroscopy measurements showed that graphene prepared by improved method exhibits superior electrochemical properties than that prepared by the other two methods. - Graphical abstract: Graphene oxides with different oxidation degree were obtained via three methods, and then graphene with different crystal structures were created by chemical reduction of exfoliated graphene oxides. - Highlights: • Graphene oxides with different oxidation degree were obtained via three oxidation methods. • The influence of oxidation methods on microstructure of graphene was investigated. • The effect of oxidation methods on dispersion stability of graphene was investigated. • The effect of oxidation methods on electrochemical properties of graphene was discussed.« less

Margins of stability in young adults with traumatic transtibial amputation walking in destabilizing environments✫

PubMed Central

Beltran, Eduardo J.; Dingwell, Jonathan B.; Wilken, Jason M.

2014-01-01

Understanding how lower-limb amputation affects walking stability, specifically in destabilizing environments, is essential for developing effective interventions to prevent falls. This study quantified mediolateral margins of stability (MOS) and MOS sub-components in young individuals with traumatic unilateral transtibial amputation (TTA) and young able-bodied individuals (AB). Thirteen AB and nine TTA completed five 3-minute walking trials in a Computer Assisted Rehabilitation ENvironment (CAREN) system under three each of three test conditions: no perturbations, pseudo-random mediolateral translations of the platform, and pseudo-random mediolateral translations of the visual field. Compared to the unperturbed trials, TTA exhibited increased mean MOS and MOS variability during platform and visual field perturbations (p < 0.010). Also, AB exhibited increased mean MOS during visual field perturbations and increased MOS variability during both platform and visual field perturbations (p < 0.050). During platform perturbations, TTA exhibited significantly greater values than AB for mean MOS (p < 0.050) and MOS variability (p < 0.050); variability of the lateral distance between the center of mass (COM) and base of support at initial contact (p < 0.005); mean and variability of the range of COM motion (p < 0.010); and variability of COM peak velocity (p < 0.050). As determined by mean MOS and MOS variability, young and otherwise healthy individuals with transtibial amputation achieved stability similar to that of their able-bodied counterparts during unperturbed and visually-perturbed walking. However, based on mean and variability of MOS, unilateral transtibial amputation was shown to have affected walking stability during platform perturbations. PMID:24444777

Nonparallel stability of three-dimensional compressible boundary layers. Part 1: Stability analysis

NASA Technical Reports Server (NTRS)

El-Hady, N. M.

1980-01-01

A compressible linear stability theory is presented for nonparallel three-dimensional boundary-layer flows, taking into account the normal velocity component as well as the streamwise and spanwise variations of the basic flow. The method of multiple scales is used to account for the nonparallelism of the basic flow, and equations are derived for the spatial evolution of the disturbance amplitude and wavenumber. The numerical procedure for obtaining the solution of the nonparallel problem is outlined.

Influence of Temperature and Grain Size on Austenite Stability in Medium Manganese Steels

NASA Astrophysics Data System (ADS)

Zhang, Yulong; Wang, Li; Findley, Kip O.; Speer, John G.

2017-05-01

With an aim to elucidate the influence of temperature and grain size on austenite stability, a commercial cold-rolled 7Mn steel was annealed at 893 K (620 °C) for times varying between 3 minutes and 96 hours to develop different grain sizes. The austenite fraction after 3 minutes was 34.7 vol pct, and at longer times was around 40 pct. An elongated microstructure was retained after shorter annealing times while other conditions exhibited equiaxed ferrite and austenite grains. All conditions exhibit similar temperature dependence of mechanical properties. With increasing test temperature, the yield and tensile strength decrease gradually, while the uniform and total elongation increase, followed by an abrupt drop in strength and ductility at 393 K (120 °C). The Olson-Cohen model was applied to fit the transformed austenite fractions for strained tensile samples, measured by means of XRD. The fit results indicate that the parameters α and β decrease with increasing test temperature, consistent with increased austenite stability. The 7Mn steels exhibit a distinct temperature dependence of the work hardening rate. Optimized austenite stability provides continuous work hardening in the temperature range of 298 K to 353 K (25 °C to 80 °C). The yield and tensile strengths have a strong dependence on grain size, although grain size variations have less effect on uniform and total elongation.

Trends in Thermostability Provide Information on the Nature of Substrate, Inhibitor, and Lipid Interactions with Mitochondrial Carriers*

PubMed Central

Crichton, Paul G.; Lee, Yang; Ruprecht, Jonathan J.; Cerson, Elizabeth; Thangaratnarajah, Chancievan; King, Martin S.; Kunji, Edmund R. S.

2015-01-01

Mitochondrial carriers, including uncoupling proteins, are unstable in detergents, which hampers structural and mechanistic studies. To investigate carrier stability, we have purified ligand-free carriers and assessed their stability with a fluorescence-based thermostability assay that monitors protein unfolding with a thiol-reactive dye. We find that mitochondrial carriers from both mesophilic and thermophilic organisms exhibit poor stability in mild detergents, indicating that instability is inherent to the protein family. Trends in the thermostability of yeast ADP/ATP carrier AAC2 and ovine uncoupling protein UCP1 allow optimal conditions for stability in detergents to be established but also provide mechanistic insights into the interactions of lipids, substrates, and inhibitors with these proteins. Both proteins exhibit similar stability profiles across various detergents, where stability increases with the size of the associated detergent micelle. Detailed analysis shows that lipids stabilize carriers indirectly by increasing the associated detergent micelle size, but cardiolipin stabilizes by direct interactions as well. Cardiolipin reverses destabilizing effects of ADP and bongkrekic acid on AAC2 and enhances large stabilizing effects of carboxyatractyloside, revealing that this lipid interacts in the m-state and possibly other states of the transport cycle, despite being in a dynamic interface. Fatty acid activators destabilize UCP1 in a similar way, which can also be prevented by cardiolipin, indicating that they interact like transport substrates. Our controls show that carriers can be soluble but unfolded in some commonly used detergents, such as the zwitterionic Fos-choline-12, which emphasizes the need for simple validation assays like the one used here. PMID:25653283

The effects of spatial autoregressive dependencies on inference in ordinary least squares: a geometric approach

NASA Astrophysics Data System (ADS)

Smith, Tony E.; Lee, Ka Lok

2012-01-01

There is a common belief that the presence of residual spatial autocorrelation in ordinary least squares (OLS) regression leads to inflated significance levels in beta coefficients and, in particular, inflated levels relative to the more efficient spatial error model (SEM). However, our simulations show that this is not always the case. Hence, the purpose of this paper is to examine this question from a geometric viewpoint. The key idea is to characterize the OLS test statistic in terms of angle cosines and examine the geometric implications of this characterization. Our first result is to show that if the explanatory variables in the regression exhibit no spatial autocorrelation, then the distribution of test statistics for individual beta coefficients in OLS is independent of any spatial autocorrelation in the error term. Hence, inferences about betas exhibit all the optimality properties of the classic uncorrelated error case. However, a second more important series of results show that if spatial autocorrelation is present in both the dependent and explanatory variables, then the conventional wisdom is correct. In particular, even when an explanatory variable is statistically independent of the dependent variable, such joint spatial dependencies tend to produce "spurious correlation" that results in over-rejection of the null hypothesis. The underlying geometric nature of this problem is clarified by illustrative examples. The paper concludes with a brief discussion of some possible remedies for this problem.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Larsen, E.W.

A class of Projected Discrete-Ordinates (PDO) methods is described for obtaining iterative solutions of discrete-ordinates problems with convergence rates comparable to those observed using Diffusion Synthetic Acceleration (DSA). The spatially discretized PDO solutions are generally not equal to the DSA solutions, but unlike DSA, which requires great care in the use of spatial discretizations to preserve stability, the PDO solutions remain stable and rapidly convergent with essentially arbitrary spatial discretizations. Numerical results are presented which illustrate the rapid convergence and the accuracy of solutions obtained using PDO methods with commonplace differencing methods.

Temporal and spatial variability of wind resources in the United States as derived from the Climate Forecast System Reanalysis

Treesearch

Lejiang Yu; Shiyuan Zhong; Xindi Bian; Warren E. Heilman

2015-01-01

This study examines the spatial and temporal variability of wind speed at 80m above ground (the average hub height of most modern wind turbines) in the contiguous United States using Climate Forecast System Reanalysis (CFSR) data from 1979 to 2011. The mean 80-m wind exhibits strong seasonality and large spatial variability, with higher (lower) wind speeds in the...

Spatial Variance in Resting fMRI Networks of Schizophrenia Patients: An Independent Vector Analysis

PubMed Central

Gopal, Shruti; Miller, Robyn L.; Michael, Andrew; Adali, Tulay; Cetin, Mustafa; Rachakonda, Srinivas; Bustillo, Juan R.; Cahill, Nathan; Baum, Stefi A.; Calhoun, Vince D.

2016-01-01

Spatial variability in resting functional MRI (fMRI) brain networks has not been well studied in schizophrenia, a disease known for both neurodevelopmental and widespread anatomic changes. Motivated by abundant evidence of neuroanatomical variability from previous studies of schizophrenia, we draw upon a relatively new approach called independent vector analysis (IVA) to assess this variability in resting fMRI networks. IVA is a blind-source separation algorithm, which segregates fMRI data into temporally coherent but spatially independent networks and has been shown to be especially good at capturing spatial variability among subjects in the extracted networks. We introduce several new ways to quantify differences in variability of IVA-derived networks between schizophrenia patients (SZs = 82) and healthy controls (HCs = 89). Voxelwise amplitude analyses showed significant group differences in the spatial maps of auditory cortex, the basal ganglia, the sensorimotor network, and visual cortex. Tests for differences (HC-SZ) in the spatial variability maps suggest, that at rest, SZs exhibit more activity within externally focused sensory and integrative network and less activity in the default mode network thought to be related to internal reflection. Additionally, tests for difference of variance between groups further emphasize that SZs exhibit greater network variability. These results, consistent with our prediction of increased spatial variability within SZs, enhance our understanding of the disease and suggest that it is not just the amplitude of connectivity that is different in schizophrenia, but also the consistency in spatial connectivity patterns across subjects. PMID:26106217

Persistent spatial information in the frontal eye field during object-based short-term memory.

PubMed

Clark, Kelsey L; Noudoost, Behrad; Moore, Tirin

2012-08-08

Spatial attention is known to gate entry into visual short-term memory, and some evidence suggests that spatial signals may also play a role in binding features or protecting object representations during memory maintenance. To examine the persistence of spatial signals during object short-term memory, the activity of neurons in the frontal eye field (FEF) of macaque monkeys was recorded during an object-based delayed match-to-sample task. In this task, monkeys were trained to remember an object image over a brief delay, regardless of the locations of the sample or target presentation. FEF neurons exhibited visual, delay, and target period activity, including selectivity for sample location and target location. Delay period activity represented the sample location throughout the delay, despite the irrelevance of spatial information for successful task completion. Furthermore, neurons continued to encode sample position in a variant of the task in which the matching stimulus never appeared in their response field, confirming that FEF maintains sample location independent of subsequent behavioral relevance. FEF neurons also exhibited target-position-dependent anticipatory activity immediately before target onset, suggesting that monkeys predicted target position within blocks. These results show that FEF neurons maintain spatial information during short-term memory, even when that information is irrelevant for task performance.

Disease Spread and Its Effect on Population Dynamics in Heterogeneous Environment

NASA Astrophysics Data System (ADS)

Upadhyay, Ranjit Kumar; Roy, Parimita

In this paper, an eco-epidemiological model in which both species diffuse along a spatial gradient has been shown to exhibit temporal chaos at a fixed point in space. The proposed model is a modification of the model recently presented by Upadhyay and Roy [2014]. The spatial interactions among the species have been represented in the form of reaction-diffusion equations. The model incorporates the intrinsic growth rate of fish population which varies linearly with the depth of water. Numerical results show that diffusion can drive otherwise stable system into aperiodic behavior with sensitivity to initial conditions. We show that spatially induced chaos plays an important role in spatial pattern formation in heterogeneous environment. Spatiotemporal distributions of species have been simulated using the diffusivity assumptions realistic for natural eco-epidemic systems. We found that in heterogeneous environment, the temporal dynamics of both the species are drastically different and show chaotic behavior. It was also found that the instability observed in the model is due to spatial heterogeneity and diffusion-driven. Cumulative death rate of predator has an appreciable effect on model dynamics as the spatial distribution of all constituent populations exhibit significant changes when this model parameter is changed and it acts as a regularizing factor.

A Microsaccadic Account of Attentional Capture and Inhibition of Return in Posner Cueing

PubMed Central

Tian, Xiaoguang; Yoshida, Masatoshi; Hafed, Ziad M.

2016-01-01

Microsaccades exhibit systematic oscillations in direction after spatial cueing, and these oscillations correlate with facilitatory and inhibitory changes in behavioral performance in the same tasks. However, independent of cueing, facilitatory and inhibitory changes in visual sensitivity also arise pre-microsaccadically. Given such pre-microsaccadic modulation, an imperative question to ask becomes: how much of task performance in spatial cueing may be attributable to these peri-movement changes in visual sensitivity? To investigate this question, we adopted a theoretical approach. We developed a minimalist model in which: (1) microsaccades are repetitively generated using a rise-to-threshold mechanism, and (2) pre-microsaccadic target onset is associated with direction-dependent modulation of visual sensitivity, as found experimentally. We asked whether such a model alone is sufficient to account for performance dynamics in spatial cueing. Our model not only explained fine-scale microsaccade frequency and direction modulations after spatial cueing, but it also generated classic facilitatory (i.e., attentional capture) and inhibitory [i.e., inhibition of return (IOR)] effects of the cue on behavioral performance. According to the model, cues reflexively reset the oculomotor system, which unmasks oscillatory processes underlying microsaccade generation; once these oscillatory processes are unmasked, “attentional capture” and “IOR” become direct outcomes of pre-microsaccadic enhancement or suppression, respectively. Interestingly, our model predicted that facilitatory and inhibitory effects on behavior should appear as a function of target onset relative to microsaccades even without prior cues. We experimentally validated this prediction for both saccadic and manual responses. We also established a potential causal mechanism for the microsaccadic oscillatory processes hypothesized by our model. We used retinal-image stabilization to experimentally control instantaneous foveal motor error during the presentation of peripheral cues, and we found that post-cue microsaccadic oscillations were severely disrupted. This suggests that microsaccades in spatial cueing tasks reflect active oculomotor correction of foveal motor error, rather than presumed oscillatory covert attentional processes. Taken together, our results demonstrate that peri-microsaccadic changes in vision can go a long way in accounting for some classic behavioral phenomena. PMID:27013991

Stability of a laminar premixed supersonic free shear layer with chemical reactions

NASA Technical Reports Server (NTRS)

Menon, S.; Anderson, J. D., Jr.; Pai, S. I.

1984-01-01

The stability of a two-dimensional compressible supersonic flow in the wake of a flat plate is discussed. The fluid is a multi-species mixture which is undergoing finite rate chemical reactions. The spatial stability of an infinitesimal disturbance in the fluid is considered. Numerical solutions of the eigenvalue stability equations for both reactive and nonreactive supersonic flows are presented and discussed. The chemical reactions have significant influence on the stability behavior. For instance, a neutral eigenvalue is observed near the freestream Mach number of 2.375 for the nonreactive case, but disappears when the reaction is turned on. For reactive flows, the eigenvalues are not very dependent on the free stream Mach number.

Spatial Variability of Snowpack Properties On Small Slopes

NASA Astrophysics Data System (ADS)

Pielmeier, C.; Kronholm, K.; Schneebeli, M.; Schweizer, J.

The spatial variability of alpine snowpacks is created by a variety of parameters like deposition, wind erosion, sublimation, melting, temperature, radiation and metamor- phism of the snow. Spatial variability is thought to strongly control the avalanche initi- ation and failure propagation processes. Local snowpack measurements are currently the basis for avalanche warning services and there exist contradicting hypotheses about the spatial continuity of avalanche active snow layers and interfaces. Very little about the spatial variability of the snowpack is known so far, therefore we have devel- oped a systematic and objective method to measure the spatial variability of snowpack properties, layering and its relation to stability. For a complete coverage, the analysis of the spatial variability has to entail all scales from mm to km. In this study the small to medium scale spatial variability is investigated, i.e. the range from centimeters to tenths of meters. During the winter 2000/2001 we took systematic measurements in lines and grids on a flat snow test field with grid distances from 5 cm to 0.5 m. Fur- thermore, we measured systematic grids with grid distances between 0.5 m and 2 m in undisturbed flat fields and on small slopes above the tree line at the Choerbschhorn, in the region of Davos, Switzerland. On 13 days we measured the spatial pattern of the snowpack stratigraphy with more than 110 snow micro penetrometer measure- ments at slopes and flat fields. Within this measuring grid we placed 1 rutschblock and 12 stuffblock tests to measure the stability of the snowpack. With the large num- ber of measurements we are able to use geostatistical methods to analyse the spatial variability of the snowpack. Typical correlation lengths are calculated from semivari- ograms. Discerning the systematic trends from random spatial variability is analysed using statistical models. Scale dependencies are shown and recurring scaling patterns are outlined. The importance of the small and medium scale spatial variability for the larger (kilometer) scale spatial variability as well as for the avalanche formation are discussed. Finally, an outlook on spatial models for the snowpack variability is given.

Navigation Patterns and Scent Marking: Underappreciated Contributors to Hippocampal and Entorhinal Spatial Representations?

PubMed

Lebedev, Mikhail A; Pimashkin, Alexey; Ossadtchi, Alexei

2018-01-01

According to the currently prevailing theory, hippocampal formation constructs and maintains cognitive spatial maps. Most of the experimental evidence for this theory comes from the studies on navigation in laboratory rats and mice, typically male animals. While these animals exhibit a rich repertoire of behaviors associated with navigation, including locomotion, head movements, whisking, sniffing, raring and scent marking, the contribution of these behavioral patterns to the hippocampal spatially-selective activity has not been sufficiently studied. Instead, many publications have considered animal position in space as the major variable that affects the firing of hippocampal place cells and entorhinal grid cells. Here we argue that future work should focus on a more detailed examination of different behaviors exhibited during navigation to better understand the mechanism of spatial tuning in hippocampal neurons. As an inquiry in this direction, we have analyzed data from two datasets, shared online, containing recordings from rats navigating in square and round arenas. Our analyses revealed patchy navigation patterns, evident from the spatial maps of animal position, velocity and acceleration. Moreover, grid cells available in the datasets exhibited similar periodicity as the navigation parameters. These findings indicate that activity of grid cells could affect navigation parameters and/or vice versa. Additionally, we speculate that scent marks left by navigating animals could contribute to neuronal responses while rats and mice sniff their environment; the act of sniffing could modulate neuronal discharges even in virtual visual environments. Accordingly, we propose that future experiments should contain additional controls for navigation patterns, whisking, sniffing and maps composed of scent marks.

Antiferroelectric Thin-Film Capacitors with High Energy-Storage Densities, Low Energy Losses, and Fast Discharge Times.

PubMed

Ahn, Chang Won; Amarsanaa, Gantsooj; Won, Sung Sik; Chae, Song A; Lee, Dae Su; Kim, Ill Won

2015-12-09

We demonstrate a capacitor with high energy densities, low energy losses, fast discharge times, and high temperature stabilities, based on Pb(0.97)Y(0.02)[(Zr(0.6)Sn(0.4))(0.925)Ti(0.075)]O3 (PYZST) antiferroelectric thin-films. PYZST thin-films exhibited a high recoverable energy density of U(reco) = 21.0 J/cm(3) with a high energy-storage efficiency of η = 91.9% under an electric field of 1300 kV/cm, providing faster microsecond discharge times than those of commercial polypropylene capacitors. Moreover, PYZST thin-films exhibited high temperature stabilities with regard to their energy-storage properties over temperatures ranging from room temperature to 100 °C and also exhibited strong charge-discharge fatigue endurance up to 1 × 10(7) cycles.

Subsonic and transonic dynamic stability characteristics of the space shuttle launch vehicle

NASA Technical Reports Server (NTRS)

Freeman, D. C., Jr.; Boyden, R. P.; Davenport, E. E.

1976-01-01

An investigation has been conducted to determine the subsonic and transonic dynamic stability characteristics of a 0.015 scale model of the space shuttle launch vehicle. These tests were conducted in the Langley 8-foot transonic pressure tunnel over a Mach number range from 0.3 to 1.2. Forced oscillation equipment was used to determine the damping characteristics of several configurations about all three axes. The test results show that the model exhibited positive damping in pitch except at the highest Mach number (1.2) where there was a region of negative damping at 2 deg angle of attack. The yawing oscillation tests show that the model exhibited nonlinearities and negative damping at Mach numbers of 0.3 and 0.6. The model exhibited positive roll damping throughout the test angle of attack and Mach range.

Intermolecular ionic cross-linked sulfonated poly(ether ether ketone) membranes containing diazafluorene for direct methanol fuel cell applications

NASA Astrophysics Data System (ADS)

Liang, Yu; Gong, Chenliang; Qi, Zhigang; Li, Hui; Wu, Zhongying; Zhang, Yakui; Zhang, Shujiang; Li, Yanfeng

2015-06-01

A series of novel ionic cross-linking sulfonated poly(ether ether ketone) (SPEEK) membranes containing the diazafluorene functional group are synthesized to reduce the swelling ratio and methanol permeability for direct methanol fuel cell (DMFC) applications. The ionic cross-linking is realized by the interaction between sulfonic acid groups and pyridyl in diazafluorene. The prepared membranes exhibit good mechanical properties, adequate thermal stability, good oxidative stability, appropriate water uptake and low swelling ratio. Moreover, the ionic cross-linked membranes exhibit lower methanol permeability in the range between 0.56 × 10-7 cm2 s-1 and 1.8 × 10-7 cm2 s-1, which is lower than Nafion 117, and they exhibit higher selectivity than Nafion 117 at 30 °C on the basis of applicable proton conductivity.

Spatial and Temporal Patterns of Throughfall Amounts and Solutes in a Tropical Montane Forest - Comparisons with Findings From Lowland Rain Forests

NASA Astrophysics Data System (ADS)

Zimmermann, A.

2007-05-01

The diverse tree species composition, irregular shaped tree crowns and a multi-layered forest structure affect the redistribution of rainfall in lower montane rain forests. In addition, abundant epiphyte biomass and associated canopy humus influence spatial patterns of throughfall. The spatial variability of throughfall amounts controls spatial patterns of solute concentrations and deposition. Moreover, the living and dead biomass interacts with the rainwater during the passage through the canopy and creates a chemical variability of its own. Since spatial and temporal patterns are intimately linked, the analysis of temporal solute concentration dynamics is an important step to understand the emerging spatial patterns. I hypothesized that: (1) the spatial variability of volumes and chemical composition of throughfall is particularly high compared with other forests because of the high biodiversity and epiphytism, (2) the temporal stability of the spatial pattern is high because of stable structures in the canopy (e.g. large epiphytes) that show only minor changes during the short term observation period, and (3) the element concentrations decrease with increasing rainfall because of exhausting element pools in the canopy. The study area at 1950 m above sea level is located in the south Ecuadorian Andes far away from anthropogenic emission sources and marine influences. Rain and throughfall were collected from August to October 2005 on an event and within-event basis for five precipitation periods and analyzed for pH, K, Na, Ca, Mg, NH4+, Cl-, NO3-, PO43-, TN, TP and TOC. Throughfall amounts and most of the solutes showed a high spatial variability, thereby the variability of H+, K, Ca, Mg, Cl- and NO3- exceeded those from a Brazilian tropical rain forest. The temporal persistence of the spatial patterns was high for throughfall amounts and varied depending on the solute. Highly persistent time stability patterns were detected for K, Mg and TOC concentrations. Time stability patterns of solute deposition were somewhat weaker than for concentrations for most of the solutes. Epiphytes strongly affected time stability patterns in that collectors situated below thick moss mats or arboreal bromeliads were in large part responsible for the extreme persistence with low throughfall amounts and high ion concentrations (H+ showed low concentrations). Rainfall solute concentrations were low compared with a variety of other tropical lowland and montane forest sites and showed a small temporal variability during the study period for both between and within-event dynamics, respectively. Throughfall solute concentrations were more within the range when compared with other sites and showed highly variable within-event dynamics. For most of the solutes, within-event concentrations did not reach low, constant concentrations in later event stages, rather concentrations fluctuated (e.g. Cl-) or increased (e.g. K and TOC). The within-event throughfall solute concentration dynamics in this lower montane rain forest contrast to recent observations from lowland tropical rain forests in Panama and Brazil. The observed within-event patterns are attributed (1) to the influence of epiphytes and associated canopy humus, and (2) to low rainfall intensities.

How do bendy straws bend? A study of re-configurability of multi-stable corrugated shells

NASA Astrophysics Data System (ADS)

Bende, Nakul; Selden, Sarah; Evans, Arthur; Santangelo, Christian; Hayward, Ryan

Shape programmable systems have evolved to allow for reconfiguration of structures through a variety of mechanisms including swelling, stress-relaxation, and thermal expansion. Particularly, there has been a recent interest in systems that exhibit bi-stability or multi-stability to achieve transformation between two or more pre-programmed states. Here, we study the ubiquitous architecture of corrugated shells, such as drinking straws or bellows, which has been well known for centuries. Some of these structures exhibit almost continuous stability amongst a wide range of reconfigurable shapes, but the underlying mechanisms are not well understood. To understand multi-stability in `bendy-straw' structures, we study the unit bi-conical segment using experiments and finite element modeling to elucidate the key geometrical and mechanical factors responsible for its multi-stability. The simple transformations of a unit segment - a change in length or angle can impart complex re-configurability of a structure containing many of these units. The fundamental understanding provided of this simple multi-stable building block could yield improvements in shape re-configurability for a wide array of applications such as corrugated medical tubing, robotics, and deployable structures. NSF EFRI ODISSEI-1240441.

Enhanced Luminescent Stability through Particle Interactions in Silicon Nanocrystal Aggregates

DOE Office of Scientific and Technical Information (OSTI.GOV)

Miller, Joseph B.; Dandu, Naveen; Velizhanin, Kirill A.

2015-10-27

Close-packed assemblies of ligand-passivated colloidal nanocrystals can exhibit enhanced photoluminescent stability, but the origin of this effect is unclear. Here, we use experiment, simulation, and ab initio computation to examine the influence of interparticle interactions on the photoluminescent stability of silicon nanocrystal aggregates. The time-dependent photoluminescence emitted by structures ranging in size from a single quantum dot to agglomerates of more than a thousand is compared with Monte Carlo simulations of noninteracting ensembles using measured single-particle blinking data as input. In contrast to the behavior typically exhibited by the metal chalcogenides, the measured photoluminescent stability shows an enhancement with respectmore » to the noninteracting scenario with increasing aggregate size. We model this behavior using time-dependent density functional theory calculations of energy transfer between neighboring nanocrystals as a function of nanocrystal size, separation, and the presence of charge and/or surface-passivation defects. Our results suggest that rapid exciton transfer from “bright” nanocrystals to surface trap states in nearest-neighbors can efficiently fill such traps and enhance the stability of emission by promoting the radiative recombination of slowly diffusing excited electrons.« less

Spatial frequency maps of power flow in metamaterials and photonic crystals: Investigating backward-wave modes across the electromagnetic spectrum

NASA Astrophysics Data System (ADS)

Aghanejad, Iman; Markley, Loïc

2017-11-01

We present spatial frequency maps of power flow in metamaterials and photonic crystals in order to provide insights into their electromagnetic responses and further our understanding of backward power in periodic structures. Since 2001, many different structures across the electromagnetic spectrum have been presented in the literature as exhibiting an isotropic negative effective index. Although these structures all exhibit circular or spherical equifrequency contours that resemble those of left-handed media, here we show through k -space diagrams that the distribution of power in the spatial frequency domain can vary considerably across these structures. In particular, we show that backward power arises from high-order right-handed harmonics in photonic crystals, magnetodielectric crystals, and across the layers of coupled-plasmonic-waveguide metamaterials, while arising from left-handed harmonic pairs in split-ring resonator and wire composites, plasmonic crystals, and along the layers of coupled-plasmonic-waveguide metamaterials. We also show that the fishnet structure exhibits the same left-handed harmonic pairs as the latter group. These observations allow us to categorize different metamaterials according to their spatial spectral source of backward power and identify the mechanism behind negative refraction at a given interface. Finally, we discuss how k -space maps of power flow can be used to explain the high or low transmittance of power into different metamaterial or photonic crystal structures.

Modular and hierarchical structure of social contact networks

NASA Astrophysics Data System (ADS)

Ge, Yuanzheng; Song, Zhichao; Qiu, Xiaogang; Song, Hongbin; Wang, Yong

2013-10-01

Social contact networks exhibit overlapping qualities of communities, hierarchical structure and spatial-correlated nature. We propose a mixing pattern of modular and growing hierarchical structures to reconstruct social contact networks by using an individual’s geospatial distribution information in the real world. The hierarchical structure of social contact networks is defined based on the spatial distance between individuals, and edges among individuals are added in turn from the modular layer to the highest layer. It is a gradual process to construct the hierarchical structure: from the basic modular model up to the global network. The proposed model not only shows hierarchically increasing degree distribution and large clustering coefficients in communities, but also exhibits spatial clustering features of individual distributions. As an evaluation of the method, we reconstruct a hierarchical contact network based on the investigation data of a university. Transmission experiments of influenza H1N1 are carried out on the generated social contact networks, and results show that the constructed network is efficient to reproduce the dynamic process of an outbreak and evaluate interventions. The reproduced spread process exhibits that the spatial clustering of infection is accordant with the clustering of network topology. Moreover, the effect of individual topological character on the spread of influenza is analyzed, and the experiment results indicate that the spread is limited by individual daily contact patterns and local clustering topology rather than individual degree.

Microbial Activity and Depositional System Dynamics: Linking Scales With The Aid of New Technology

NASA Astrophysics Data System (ADS)

Defew, E. C.; Hagerthey, S. E.; Honeywill, C.; Perkins, R. G.; Black, K. S.; Paterson, D. M.

The dynamics of estuarine depositional systems are influenced by sediment-dwelling microphytobenthic assemblages. These assemblages produce extracellular polymeric substances (EPS), which are known to be important in the process of sediment biosta- bilisation. However, these communities are generally studied on very small spatial scales making the prediction of primary productivity and their importance in terms of sediment stability over large areas uncertain. Recent advances in our knowledge of the biostabilisation process have allowed the establishment of links between EPS produc- tion, spatial distribution of algal biomass and their primary productivity over much larger spatial scales. For example, during the multidisciplinary BIOPTIS project, re- mote sensing (RS) was combined with ground-truthing measurements of physical and biological parameters to produce synoptic maps leading to a better understanding of system dynamics and the potential effects of environmental perturbations such as cli- mate change. Recent work using low-temperature scanning electron microscopy (LT- SEM) and in-line laser holography has measured the influence of EPS on the erosional behaviour of sediment flocs and particles and has shown that an increase in the con- centration of EPS determines the nature of the eroded floc material and the critical threshold for sediment erosion. This provides the mechanistic link required between EPS concentration and sediment stability. Whilst it is not yet possible to discern EPS concentration directly by RS studies, we know that EPS concentrations in sediments co-vary with chlorophyll a content, and are closely related to algal productivity. There- fore, RS studies which provide large-scale spatial information of chlorophyll a distri- bution may be used to model the stability and productivity of intertidal depositional systems. This paper introduces the basis of these linkages from the cellular level (in situ chlorophyll fluorescence), the ground-truthing approach (sediment stability, struc- ture, pigment distribution, in situ chlorophyll fluorescence) and investigates the poten- tial of a RS approach in a case study of a Scottish Estuary.

Role of anisotropy in determining stability of electrodeposition at solid-solid interfaces

DOE PAGES

Ahmad, Zeeshan; Viswanathan, Venkatasubramanian

2017-10-24

Here, we investigate the stability of electrodeposition at solid-solid interfaces for materials exhibiting an anisotropic mechanical response. The stability of electrodeposition or resistance to the formation of dendrites is studied within a linear stability analysis. The deformation and stress equations are solved using the Stroh formalism and faithfully recover the boundary conditions at the interface. The stability parameter is used to quantify the stability of different solid-solid interfaces incorporating the full anisotropy of the elastic tensor of the two materials. Our results show a high degree of variability in the stability parameter depending on the crystallographic orientation of the solidsmore » in contact, and point to opportunities for exploiting this effect in developing Li metal anodes.« less

Gender difference of ankle stability in the sagittal and frontal planes.

PubMed

Hanzlick, Harrison; Hyunglae Lee

2017-07-01

This paper offers quantification of ankle stability in relation to simulated haptic environments of varying stiffness. This study analyzes the stability trends of male and female subjects independently over a wide range of simulated environments after subjects were exposed to vigorous position perturbation. Ankle stability was quantified for both degrees-of-freedom of the ankle in the sagittal and frontal planes. Subjects' stability consistently decreased when exposed to environments of negative simulated stiffness. In the frontal plane, male and female subjects exhibited nearly identical stability levels. In the sagittal plane, however, male subjects demonstrated marginally more stability than female subjects in environments with negative stiffness. Results of this study are beneficial to understanding situations in which the ankle is likely to lose stability, potentially resulting in injury.

Topography and Radiative Forcing Patterns on Glaciers in the Karakoram Himalaya

NASA Astrophysics Data System (ADS)

Dobreva, I. D.; Bishop, M. P.; Liu, J. C.; Liang, D.

2015-12-01

Glaciers in the western Himalaya exhibit significant spatial variations in morphology and dynamics. Climate, topography and debris cover variations are thought to significantly affect glacier fluctuations and glacier sensitivity to climate change, although the role of topography and radiative forcing have not been adequately characterized and related to glacier fluctuations and dynamics. Consequently, we examined the glaciers in the Karakoram Himalaya, as they exhibit high spatial variability in glacier fluctuation rates and ice dynamics including flow velocity and surging. Specifically, we wanted to examine the relationships between these glacier characteristics and temporal patterns of surface irradiance over the ablation season. To accomplish this, we developed and used a rigorous GIS-based solar radiative transfer model that accounts for the direct and diffuse-skylight irradiance components. The model accounts for multiple topographic effects on the magnitude of irradiance reaching glacier surfaces. We specifically used the ASTER GDEM digital elevation model for irradiance simulations. We then examined temporal patterns of irradiance at the grid-cell level to identify the dominant patterns that were used to train a 3-layer artificial neural network. Our results demonstrate that there are unique spatial and temporal patterns associated with downwasting and surging glaciers, and that these patterns partially account for the spatial distribution of advancing and retreating glaciers. Lower-altitude terminus regions of surging glaciers exhibited relatively low surface irradiance values that decreased in magnitude with time, demonstrating that high-velocity surging glaciers facilitate relief production and exhibit steeper surface irradiance gradients with altitude. Collectively, these results demonstrate the important role that local and regional topography play in governing climate-glacier dynamics in the Himalaya.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ahmad, Zeeshan; Viswanathan, Venkatasubramanian

Here, we investigate the stability of electrodeposition at solid-solid interfaces for materials exhibiting an anisotropic mechanical response. The stability of electrodeposition or resistance to the formation of dendrites is studied within a linear stability analysis. The deformation and stress equations are solved using the Stroh formalism and faithfully recover the boundary conditions at the interface. The stability parameter is used to quantify the stability of different solid-solid interfaces incorporating the full anisotropy of the elastic tensor of the two materials. Our results show a high degree of variability in the stability parameter depending on the crystallographic orientation of the solidsmore » in contact, and point to opportunities for exploiting this effect in developing Li metal anodes.« less

Effects of chloride additives on the mechanical stability and environmental durability of porous MgF2 thin films

NASA Astrophysics Data System (ADS)

Schütz, F.; Scheurell, K.; Scholz, G.; Kemnitz, E.

2016-09-01

Porous antireflective thin films, prepared of nanoscopic MgF2 sols, exhibit a low refraction index and are useful for various optical applications. Due to their porosity, film stability and durability suffer from mechanical abrasion and water solubility, respectively. Hence, we present approaches of improved mechanical stability of MgF2 layers induced by chloride addition. Antireflective (AR) films were produced by dip-coating followed by thermal treatment. Afterwards, film stability and environmental durability was strained by crockmeter and water stability tests, respectively. In comparison to films prepared from chloride-free MgF2 sols, chloride mingled sols form coatings with increased mechanical stability and a lower solubility.

Hiding in Plain Sight: A Case for Cryptic Metapopulations in Brook Trout (Salvelinus fontinalis)

PubMed Central

Kazyak, David C.; Hilderbrand, Robert H.; King, Tim L.; Keller, Stephen R.; Chhatre, Vikram E.

2016-01-01

A fundamental issue in the management and conservation of biodiversity is how to define a population. Spatially contiguous fish occupying a stream network have often been considered to represent a single, homogenous population. However, they may also represent multiple discrete populations, a single population with genetic isolation-by-distance, or a metapopulation. We used microsatellite DNA and a large-scale mark-recapture study to assess population structure in a spatially contiguous sample of Brook Trout (Salvelinus fontinalis), a species of conservation concern. We found evidence for limited genetic exchange across small spatial scales and in the absence of barriers to physical movement. Mark-recapture and stationary passive integrated transponder antenna records demonstrated that fish from two tributaries very seldom moved into the opposite tributary, but movements between the tributaries and mainstem were more common. Using Bayesian genetic clustering, we identified two genetic groups that exhibited significantly different growth rates over three years of study, yet survival rates were very similar. Our study highlights the importance of considering the possibility of multiple genetically distinct populations occurring within spatially contiguous habitats, and suggests the existence of a cryptic metapopulation: a spatially continuous distribution of organisms exhibiting metapopulation-like behaviors. PMID:26730588

Spatial probabilistic pulsatility model for enhancing photoplethysmographic imaging systems

NASA Astrophysics Data System (ADS)

Amelard, Robert; Clausi, David A.; Wong, Alexander

2016-11-01

Photoplethysmographic imaging (PPGI) is a widefield noncontact biophotonic technology able to remotely monitor cardiovascular function over anatomical areas. Although spatial context can provide insight into physiologically relevant sampling locations, existing PPGI systems rely on coarse spatial averaging with no anatomical priors for assessing arterial pulsatility. Here, we developed a continuous probabilistic pulsatility model for importance-weighted blood pulse waveform extraction. Using a data-driven approach, the model was constructed using a 23 participant sample with a large demographic variability (11/12 female/male, age 11 to 60 years, BMI 16.4 to 35.1 kg·m-2). Using time-synchronized ground-truth blood pulse waveforms, spatial correlation priors were computed and projected into a coaligned importance-weighted Cartesian space. A modified Parzen-Rosenblatt kernel density estimation method was used to compute the continuous resolution-agnostic probabilistic pulsatility model. The model identified locations that consistently exhibited pulsatility across the sample. Blood pulse waveform signals extracted with the model exhibited significantly stronger temporal correlation (W=35,p<0.01) and spectral SNR (W=31,p<0.01) compared to uniform spatial averaging. Heart rate estimation was in strong agreement with true heart rate [r2=0.9619, error (μ,σ)=(0.52,1.69) bpm].

Hiding in Plain Sight: A Case for Cryptic Metapopulations in Brook Trout (Salvelinus fontinalis).

PubMed

Kazyak, David C; Hilderbrand, Robert H; King, Tim L; Keller, Stephen R; Chhatre, Vikram E

2016-01-01

A fundamental issue in the management and conservation of biodiversity is how to define a population. Spatially contiguous fish occupying a stream network have often been considered to represent a single, homogenous population. However, they may also represent multiple discrete populations, a single population with genetic isolation-by-distance, or a metapopulation. We used microsatellite DNA and a large-scale mark-recapture study to assess population structure in a spatially contiguous sample of Brook Trout (Salvelinus fontinalis), a species of conservation concern. We found evidence for limited genetic exchange across small spatial scales and in the absence of barriers to physical movement. Mark-recapture and stationary passive integrated transponder antenna records demonstrated that fish from two tributaries very seldom moved into the opposite tributary, but movements between the tributaries and mainstem were more common. Using Bayesian genetic clustering, we identified two genetic groups that exhibited significantly different growth rates over three years of study, yet survival rates were very similar. Our study highlights the importance of considering the possibility of multiple genetically distinct populations occurring within spatially contiguous habitats, and suggests the existence of a cryptic metapopulation: a spatially continuous distribution of organisms exhibiting metapopulation-like behaviors.

Theory and Measurement of Partially Correlated Persistent Scatterers

NASA Astrophysics Data System (ADS)

Lien, J.; Zebker, H. A.

2011-12-01

Interferometric synthetic aperture radar (InSAR) time-series methods can effectively estimate temporal surface changes induced by geophysical phenomena. However, such methods are susceptible to decorrelation due to spatial and temporal baselines (radar pass separation), changes in orbital geometries, atmosphere, and noise. These effects limit the number of interferograms that can be used for differential analysis and obscure the deformation signal. InSAR decorrelation effects may be ameliorated by exploiting pixels that exhibit phase stability across the stack of interferograms. These so-called persistent scatterer (PS) pixels are dominated by a single point-like scatterer that remains phase-stable over the spatial and temporal baseline. By identifying a network of PS pixels for use in phase unwrapping, reliable deformation measurements may be obtained even in areas of low correlation, where traditional InSAR techniques fail to produce useful observations. PS identification is challenging in natural terrain, due to low reflectivity and few corner reflectors. Shanker and Zebker [1] proposed a PS pixel selection technique based on maximum-likelihood estimation of the associated signal-to-clutter ratio (SCR). In this study, we further develop the underlying theory for their technique, starting from statistical backscatter characteristics of PS pixels. We derive closed-form expressions for the spatial, rotational, and temporal decorrelation of PS pixels as a function of baseline and signal-to-clutter ratio. We show that previous decorrelation and critical baseline expressions [2] are limiting cases of our result. We then describe a series of radar scattering simulations and show that the simulated decorrelation matches well with our analytic results. Finally, we use our decorrelation expressions with maximum-likelihood SCR estimation to analyze an area of the Hayward Fault Zone in the San Francisco Bay Area. A series of 38 images of the area were obtained from C-band ERS radar satellite passes between May 1995 and December 2000. We show that the interferogram stack exhibits PS decorrelation trends in agreement with our analytic results. References 1. P. Shanker and H. Zebker, "Persistent scatterer selection using maximum likelihood estimation," Geophysical Research Letters, Vol. 34, L22301, 2007. 2. H. Zebker and J. Villasenor, "Decorrelation in Interferometric Radar Echos," IEEE Transactions on Geoscience and Remote Sensing, Vol. 30, No. 5, Sept. 1992.

Smoothing effect for spatially distributed renewable resources and its impact on power grid robustness.

PubMed

Nagata, Motoki; Hirata, Yoshito; Fujiwara, Naoya; Tanaka, Gouhei; Suzuki, Hideyuki; Aihara, Kazuyuki

2017-03-01

In this paper, we show that spatial correlation of renewable energy outputs greatly influences the robustness of the power grids against large fluctuations of the effective power. First, we evaluate the spatial correlation among renewable energy outputs. We find that the spatial correlation of renewable energy outputs depends on the locations, while the influence of the spatial correlation of renewable energy outputs on power grids is not well known. Thus, second, by employing the topology of the power grid in eastern Japan, we analyze the robustness of the power grid with spatial correlation of renewable energy outputs. The analysis is performed by using a realistic differential-algebraic equations model. The results show that the spatial correlation of the energy resources strongly degrades the robustness of the power grid. Our results suggest that we should consider the spatial correlation of the renewable energy outputs when estimating the stability of power grids.

Power law analysis of the human microbiome.

PubMed

Ma, Zhanshan Sam

2015-11-01

Taylor's (1961, Nature, 189:732) power law, a power function (V = am(b) ) describing the scaling relationship between the mean and variance of population abundances of organisms, has been found to govern the population abundance distributions of single species in both space and time in macroecology. It is regarded as one of few generalities in ecology, and its parameter b has been widely applied to characterize spatial aggregation (i.e. heterogeneity) and temporal stability of single-species populations. Here, we test its applicability to bacterial populations in the human microbiome using extensive data sets generated by the US-NIH Human Microbiome Project (HMP). We further propose extending Taylor's power law from the population to the community level, and accordingly introduce four types of power-law extensions (PLEs): type I PLE for community spatial aggregation (heterogeneity), type II PLE for community temporal aggregation (stability), type III PLE for mixed-species population spatial aggregation (heterogeneity) and type IV PLE for mixed-species population temporal aggregation (stability). Our results show that fittings to the four PLEs with HMP data were statistically extremely significant and their parameters are ecologically sound, hence confirming the validity of the power law at both the population and community levels. These findings not only provide a powerful tool to characterize the aggregations of population and community in both time and space, offering important insights into community heterogeneity in space and/or stability in time, but also underscore the three general properties of power laws (scale invariance, no average and universality) and their specific manifestations in our four PLEs. © 2015 John Wiley & Sons Ltd.

Spatial Atmospheric Pressure Atomic Layer Deposition of Tin Oxide as an Impermeable Electron Extraction Layer for Perovskite Solar Cells with Enhanced Thermal Stability.

PubMed

Hoffmann, Lukas; Brinkmann, Kai O; Malerczyk, Jessica; Rogalla, Detlef; Becker, Tim; Theirich, Detlef; Shutsko, Ivan; Görrn, Patrick; Riedl, Thomas

2018-02-14

Despite the notable success of hybrid halide perovskite-based solar cells, their long-term stability is still a key-issue. Aside from optimizing the photoactive perovskite, the cell design states a powerful lever to improve stability under various stress conditions. Dedicated electrically conductive diffusion barriers inside the cell stack, that counteract the ingress of moisture and prevent the migration of corrosive halogen species, can substantially improve ambient and thermal stability. Although atomic layer deposition (ALD) is excellently suited to prepare such functional layers, ALD suffers from the requirement of vacuum and only allows for a very limited throughput. Here, we demonstrate for the first time spatial ALD-grown SnO x at atmospheric pressure as impermeable electron extraction layers for perovskite solar cells. We achieve optical transmittance and electrical conductivity similar to those in SnO x grown by conventional vacuum-based ALD. A low deposition temperature of 80 °C and a high substrate speed of 2.4 m min -1 yield SnO x layers with a low water vapor transmission rate of ∼10 -4 gm -2 day -1 (at 60 °C/60% RH). Thereby, in perovskite solar cells, dense hybrid Al:ZnO/SnO x electron extraction layers are created that are the key for stable cell characteristics beyond 1000 h in ambient air and over 3000 h at 60 °C. Most notably, our work of introducing spatial ALD at atmospheric pressure paves the way to the future roll-to-roll manufacturing of stable perovskite solar cells.

A review and guidance for pattern selection in spatiotemporal system

NASA Astrophysics Data System (ADS)

Wang, Chunni; Ma, Jun

2018-03-01

Pattern estimation and selection in media can give important clues to understand the collective response to external stimulus by detecting the observable variables. Both reaction-diffusion systems (RDs) and neuronal networks can be treated as multi-agent systems from molecular level, intrinsic cooperation, competition. An external stimulus or attack can cause collapse of spatial order and distribution, while appropriate noise can enhance the consensus in the spatiotemporal systems. Pattern formation and synchronization stability can bridge isolated oscillators and the network by coupling these nodes with appropriate connection types. As a result, the dynamical behaviors can be detected and discussed by developing different spatial patterns and realizing network synchronization. Indeed, the collective response of network and multi-agent system depends on the local kinetics of nodes and cells. It is better to know the standard bifurcation analysis and stability control schemes before dealing with network problems. In this review, dynamics discussion and synchronization control on low-dimensional systems, pattern formation and synchronization stability on network, wave stability in RDs and neuronal network are summarized. Finally, possible guidance is presented when some physical effects such as polarization field and electromagnetic induction are considered.

Counteraction of antibiotic production and degradation stabilizes microbial communities

PubMed Central

Kelsic, Eric D.; Zhao, Jeffrey; Vetsigian, Kalin; Kishony, Roy

2015-01-01

Summary A major challenge in theoretical ecology is understanding how natural microbial communities support species diversity1-8, and in particular how antibiotic producing, sensitive and resistant species coexist9-15. While cyclic “rock-paper-scissors” interactions can stabilize communities in spatial environments9-11, coexistence in unstructured environments remains an enigma12,16. Here, using simulations and analytical models, we show that the opposing actions of antibiotic production and degradation enable coexistence even in well-mixed environments. Coexistence depends on 3-way interactions where an antibiotic degrading species attenuates the inhibitory interactions between two other species. These 3-way interactions enable coexistence that is robust to substantial differences in inherent species growth rates and to invasion by “cheating” species that cease producing or degrading antibiotics. At least two antibiotics are required for stability, with greater numbers of antibiotics enabling more complex communities and diverse dynamical behaviors ranging from stable fixed-points to limit cycles and chaos. Together, these results show how multi-species antibiotic interactions can generate ecological stability in both spatial and mixed microbial communities, suggesting strategies for engineering synthetic ecosystems and highlighting the importance of toxin production and degradation for microbial biodiversity. PMID:25992546

Polypyrrole-polyoxometalate/reduced graphene oxide ternary nanohybrids for flexible, all-solid-state supercapacitors.

PubMed

Chen, Yuyun; Han, Min; Tang, Yujia; Bao, Jianchun; Li, Shunli; Lan, Yaqian; Dai, Zhihui

2015-08-11

Novel polypyrrole-polyoxometalate/reduced graphene oxide ternary nanohybrids (TNHs) are synthesized via a one-pot redox relay strategy. The TNHs exhibit high areal specific capacitance (2.61 mF cm(-2)), and the fabricated solid device also exhibits good rate capability, excellent flexibility and mechanical stability.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mieno, H.; Kabe, R.; Allendorf, M. D.

Here, the first metal–organic framework exhibiting thermally activated delayed fluorescence (TADF) was developed. The zirconium-based framework (UiO-68-dpa) uses a newly designed linker composed of a terphenyl backbone, an electron-accepting carboxyl group, and an electron-donating diphenylamine and exhibits green TADF emission with a photoluminescence quantum yield of 30% and high thermal stability.

Fragility and hysteretic creep in frictional granular jamming.

PubMed

Bandi, M M; Rivera, M K; Krzakala, F; Ecke, R E

2013-04-01

The granular jamming transition is experimentally investigated in a two-dimensional system of frictional, bidispersed disks subject to quasistatic, uniaxial compression without vibrational disturbances (zero granular temperature). Three primary results are presented in this experimental study. First, using disks with different static friction coefficients (μ), we experimentally verify numerical results that predict jamming onset at progressively lower packing fractions with increasing friction. Second, we show that the first compression cycle measurably differs from subsequent cycles. The first cycle is fragile-a metastable configuration with simultaneous jammed and unjammed clusters-over a small packing fraction interval (φ(1)<φ<φ(2)) and exhibits simultaneous exponential rise in pressure and exponential decrease in disk displacements over the same packing fraction interval. This fragile behavior is explained through a percolation mechanism of stressed contacts where cluster growth exhibits spatial correlation with disk displacements and contributes to recent results emphasizing fragility in frictional jamming. Control experiments show that the fragile state results from the experimental incompatibility between the requirements for zero friction and zero granular temperature. Measurements with several disk materials of varying elastic moduli E and friction coefficients μ show that friction directly controls the start of the fragile state but indirectly controls the exponential pressure rise. Finally, under repetitive loading (compression) and unloading (decompression), we find the system exhibits pressure hysteresis, and the critical packing fraction φ(c) increases slowly with repetition number. This friction-induced hysteretic creep is interpreted as the granular pack's evolution from a metastable to an eventual structurally stable configuration. It is shown to depend on the quasistatic step size Δφ, which provides the only perturbative mechanism in the experimental protocol, and the friction coefficient μ, which acts to stabilize the pack.

Metastable dynamical patterns and their stabilization in arrays of bidirectionally coupled sigmoidal neurons

NASA Astrophysics Data System (ADS)

Horikawa, Yo

2013-12-01

Transient patterns in a bistable ring of bidirectionally coupled sigmoidal neurons were studied. When the system had a pair of spatially uniform steady solutions, the instability of unstable spatially nonuniform steady solutions decreased exponentially with the number of neurons because of the symmetry of the system. As a result, transient spatially nonuniform patterns showed dynamical metastability: Their duration increased exponentially with the number of neurons and the duration of randomly generated patterns obeyed a power-law distribution. However, these metastable dynamical patterns were easily stabilized in the presence of small variations in coupling strength. Metastable rotating waves and their pinning in the presence of asymmetry in the direction of coupling and the disappearance of metastable dynamical patterns due to asymmetry in the output function of a neuron were also examined. Further, in a two-dimensional array of neurons with nearest-neighbor coupling, intrinsically one-dimensional patterns were dominant in transients, and self-excitation in these neurons affected the metastable dynamical patterns.

Similarity-based cooperation and spatial segregation

NASA Astrophysics Data System (ADS)

Traulsen, Arne; Claussen, Jens Christian

2004-10-01

We analyze a cooperative game, where the cooperative act is not based on the previous behavior of the coplayer, but on the similarity between the players. This system has been studied in a mean-field description recently [A. Traulsen and H. G. Schuster, Phys. Rev. E 68, 046129 (2003)]. Here, the spatial extension to a two-dimensional lattice is studied, where each player interacts with eight players in a Moore neighborhood. The system shows a strong segregation independent of parameters. The introduction of a local conversion mechanism towards tolerance allows for four-state cycles and the emergence of spiral waves in the spatial game. In the case of asymmetric costs of cooperation a rich variety of complex behavior is observed depending on both cooperation costs. Finally, we study the stabilization of a cooperative fixed point of a forecast rule in the symmetric game, which corresponds to cooperation across segregation borders. This fixed point becomes unstable for high cooperation costs, but can be stabilized by a linear feedback mechanism.

Hopf Bifurcation Analysis of a Gene Regulatory Network Mediated by Small Noncoding RNA with Time Delays and Diffusion

NASA Astrophysics Data System (ADS)

Li, Chengxian; Liu, Haihong; Zhang, Tonghua; Yan, Fang

2017-12-01

In this paper, a gene regulatory network mediated by small noncoding RNA involving two time delays and diffusion under the Neumann boundary conditions is studied. Choosing the sum of delays as the bifurcation parameter, the stability of the positive equilibrium and the existence of spatially homogeneous and spatially inhomogeneous periodic solutions are investigated by analyzing the corresponding characteristic equation. It is shown that the sum of delays can induce Hopf bifurcation and the diffusion incorporated into the system can effect the amplitude of periodic solutions. Furthermore, the spatially homogeneous periodic solution always exists and the spatially inhomogeneous periodic solution will arise when the diffusion coefficients of protein and mRNA are suitably small. Particularly, the small RNA diffusion coefficient is more robust and its effect on model is much less than protein and mRNA. Finally, the explicit formulae for determining the direction of Hopf bifurcation and the stability of the bifurcating periodic solutions are derived by employing the normal form theory and center manifold theorem for partial functional differential equations. Finally, numerical simulations are carried out to illustrate our theoretical analysis.

Economic agglomerations and spatio-temporal cycles in a spatial growth model with capital transport cost

NASA Astrophysics Data System (ADS)

Juchem Neto, J. P.; Claeyssen, J. C. R.; Pôrto Júnior, S. S.

2018-03-01

In this paper we introduce capital transport cost in a unidimensional spatial Solow-Swan model of economic growth with capital-induced labor migration, considered in an unbounded domain. Proceeding with a stability analysis, we show that there is a critical value for the capital transport cost where the dynamic behavior of the economy changes, provided that the intensity of capital-induced labor migration is strong enough. On the one hand, if the capital transport cost is higher than this critical value, the spatially homogeneous equilibrium of coexistence of the model is stable, and the economy converges to this spatially homogeneous state in the long run; on the other hand, if transport cost is lower than this critical value, the equilibrium is unstable, and the economy may develop different spatio-temporal dynamics, including the formation of stable economic agglomerations and spatio-temporal economic cycles, depending on the other parameters in the model. Finally, numerical simulations support the results of the stability analysis, and illustrate the spatio-temporal dynamics generated by the model, suggesting that the economy as a whole benefits from the formation of economic agglomerations and cycles, with a higher capital transport cost reducing this gain.

Stability and Control Properties of an Aeroelastic Fixed Wing Micro Aerial Vehicle

NASA Technical Reports Server (NTRS)

Waszak, Martin R.; Jenkins, Luther N.; Ifju, Peter

2001-01-01

Micro aerial vehicles have been the subject of considerable interest and development over the last several years. The majority of current vehicle concepts rely on rigid fixed wings or rotors. An alternate design based on an aeroelastic membrane wing concept has also been developed that has exhibited desired characteristics in flight test demonstrations and competition. This paper presents results from a wind tunnel investigation that sought to quantify stability and control properties for a family of vehicles using the aeroelastic design. The results indicate that the membrane wing does exhibit potential benefits that could be exploited to enhance the design of future flight vehicles.

A C-Te-based binary OTS device exhibiting excellent performance and high thermal stability for selector application.

PubMed

Chekol, Solomon Amsalu; Yoo, Jongmyung; Park, Jaehyuk; Song, Jeonghwan; Sung, Changhyuck; Hwang, Hyunsang

2018-08-24

In this letter, we demonstrate a new binary ovonic threshold switching (OTS) selector device scalable down to ø30 nm based on C-Te. Our proposed selector device exhibits outstanding performance such as a high switching ratio (I on /I off  > 10 5 ), an extremely low off-current (∼1 nA), an extremely fast operating speed of <10 ns (transition time of <2 ns and delay time of <8 ns), high endurance (10 9 ), and high thermal stability (>450 °C). The observed high thermal stability is caused by the relatively small atomic size of C, compared to Te, which can effectively suppress the segregation and crystallization of Te in the OTS film. Furthermore, to confirm the functionality of the selector in a crossbar array, we evaluated a 1S-1R device by integrating our OTS device with a ReRAM (resistive random access memory) device. The 1S-1R integrated device exhibits a successful suppression of leakage current at the half-selected cell and shows an excellent read-out margin (>2 12 word lines) in a fast read operation.

PMR polyimide compositions for improved performance at 371 deg C

NASA Technical Reports Server (NTRS)

Vannucci, Raymond D.

1987-01-01

Studies were conducted to identify matrix resins which have potential for use at 371 C (700 F). Utilizing PMR methodology, neat resin moldings were prepared with various monomer reactants and screened for thermo-oxidative stability at 371 C (700 F) under both ambient and a four-atmosphere air pressure. The results of the resin screening studies indicate that high molecular weight (HMW) formulated resins of first (PMR-15) and second (PMR-II) generation PMR materials exhibit lower levels of weight loss at 371 C (700 F) than PMR-15 and PMR-II resins. The resin systems which exhibited the best overall balance of processability, Tg and thermo-oxidative stability at 371 C were used to prepare unidirectional Celion 6000 and T-40R graphite fiber laminates. Laminates were evaluated for thermo-oxidative stability and 371 C mechanical properties. Results of the laminate evaluation studies indicate that two of the resin compositions have potential for use in 371 C applications. The most promising resin composition provided laminates which exhibited no drop in 371 C mechanical properties and only 11 percent weight loss after 200 hr exposure to 4 atmospheres of air at 371 C.

Local dynamic stability of lower extremity joints in lower limb amputees during slope walking.

PubMed

Chen, Jin-Ling; Gu, Dong-Yun

2013-01-01

Lower limb amputees have a higher fall risk during slope walking compared with non-amputees. However, studies on amputees' slope walking were not well addressed. The aim of this study was to identify the difference of slope walking between amputees and non-amputees. Lyapunov exponents λS was used to estimate the local dynamic stability of 7 transtibial amputees' and 7 controls' lower extremity joint kinematics during uphill and downhill walking. Compared with the controls, amputees exhibited significantly lower λS in hip (P=0.04) and ankle (P=0.01) joints of the sound limb, and hip joints (P=0.01) of the prosthetic limb during uphill walking, while they exhibited significantly lower λS in knee (P=0.02) and ankle (P=0.03) joints of the sound limb, and hip joints (P=0.03) of the prosthetic limb during downhill walking. Compared with amputees level walking, they exhibited significantly lower λS in ankle joints of the sound limb during both uphill (P=0.01) and downhill walking (P=0.01). We hypothesized that the better local dynamic stability of amputees was caused by compensation strategy during slope walking.

Trapped Field Characteristics of Stacked YBCO Thin Plates for Compact NMR Magnets: Spatial Field Distribution and Temporal Stability

PubMed Central

Hahn, Seungyong; Kim, Seok Beom; Ahn, Min Cheol; Voccio, John; Bascuñán, Juan; Iwasa, Yukikazu

2010-01-01

This paper presents experimental and analytical results of trapped field characteristics of a stack of square YBCO thin film plates for compact NMR magnets. Each YBCO plate, 40 mm × 40 mm × 0.08 mm, has a 25-mm diameter hole at its center. A total of 500 stacked plates were used to build a 40-mm long magnet. Its trapped field, in a bath of liquid nitrogen, was measured for spatial field distribution and temporal stability. Comparison of measured and analytical results is presented: the effects on trapped field characteristics of the unsaturated nickel substrate and the non-uniform current distribution in the YBCO plate are discussed. PMID:20585463

Annulated Dialkoxybenzenes as Catholyte Materials for Non-aqueous Redox Flow Batteries: Achieving High Chemical Stability through Bicyclic Substitution

DOE PAGES

Zhang, Jingjing; Yang, Zheng; Shkrob, Ilya A.; ...

2017-07-21

1,4-Dimethoxybenzene derivatives are materials of choice for use as catholytes in nonaqueous redox flow batteries, as they exhibit high open-circuit potentials and excellent electrochemical reversibility. However, chemical stability of these materials in their oxidized form needs to be improved. Disubstitution in the arene ring is used to suppress parasitic reactions of their radical cations, but this does not fully prevent ring-addition reactions. By incorporating bicyclic substitutions and ether chains into the dialkoxybenzenes, a novel catholyte molecule, 9,10-bis(2-methoxyethoxy)-1,2,3,4,5,6,7,8-octahydro-1,4:5,8-dimethanenoanthracene (BODMA), is obtained and exhibits greater solubility and superior chemical stability in the charged state. As a result, a hybrid flow cell containingmore » BODMA is operated for 150 charge–discharge cycles with minimal loss of capacity.« less

Enhanced stabilization of collagen by furfural.

PubMed

Lakra, Rachita; Kiran, Manikantan Syamala; Usha, Ramamoorthy; Mohan, Ranganathan; Sundaresan, Raja; Korrapati, Purna Sai

2014-04-01

Furfural (2-furancarboxaldehyde), a product derived from plant pentosans, has been investigated for its interaction with collagen. Introduction of furfural during fibril formation enhanced the thermal and mechanical stability of collagen. Collagen films treated with furfural exhibited higher denaturation temperature (Td) (p<0.04) and showed a 3-fold increase in Young's modulus (p<0.04) at higher concentration. Furfural and furfural treated collagen films did not have any cytotoxic effect. Rheological characterization showed an increase in shear stress and shear viscosity with increasing shear rate for treated collagen. Circular dichroism (CD) studies indicated that the furfural did not have any impact on triple helical structure of collagen. Scanning electron microscopy (SEM) of furfural treated collagen exhibited small sized porous structure in comparison with untreated collagen. Thus this study provides an alternate ecologically safe crosslinking agent for improving the stability of collagen for biomedical and industrial applications. Copyright © 2014 Elsevier B.V. All rights reserved.

Mapping fields of 137Cs contamination in soils in the context of their stability and hierarchical spatial structure

NASA Astrophysics Data System (ADS)

Korobova, E.; Romanov, S.

2009-04-01

Technogenic radioisotopes now dispersed in the environment are involved in natural and technogenic processes forming specific geochemical fields and serving as tracers of modern mass migration and geofield transformation. Cs-137 radioisotopes having a comparatively long life time are known for a fast fixation by the top soil layer; radiocesium activity can be measured in the surface layer in field conditions. This makes 137Cs rather convenient for the study and modeling a behavior of toxic elements in soils [1-3, 5] and for the investigation of relative stability and hierarchical fractal structures of the soil contamination of the atmospheric origin [2]. The objective of the experimental study performed on the test site in Bryansk region was to find and prove polycentric regularities in the structure of 137Cs contamination field formed after the Chernobyl accident in natural conditions. Such a character of spatial variability can be seen on the maps showing different soil parameters and chemical element distribution measured in grids [3-5]. The research was undertaken to support our idea of the regular patterns in the contamination field structure that enables to apply a mathematical theory of the field to the geochemical fields modeling on the basis of a limited number of direct measurements sufficient to reproduce the configuration and main parameters of the geochemical field structure on the level of the elementary landscape geochemical system (top-slope-bottom). Cs-137 field measurements were verified by a direct soil sampling. Soil cores dissected into subsamples with increments of 2, 5 and 10 cm, were taken to the depth of 40 cm at points with various surface activity located at different elements of relief. According to laboratory measurements 137Cs inventory in soils varied from 344 to 3448 kBq/m2 (983 kBq/m2 on the average). From 95,1% to 98,0% to of the total inventory was retained in the top 20-cm soil layer. This confirmed that field gamma spectrometry could be used to investigate patterns of 137Cs spatial redistribution in the top soil layers. The portion of 137Cs conserved in top layers corresponded to the meso- and micro relief elements. The character and stability of 137Cs spatial structure was studied by measuring its activity within nested plots with different steps of 5, 2, 1 and 0,2 m (the latter was a minimum resolution step for the field NaI detector). Performed measurements showed that the contamination field of 137Cs had a regular structure of polycentric character and exhibited a decrease in spatial variability of contamination with the decrease of the measured area. Repeated measurements of soil contamination in successive years of 2005-2008 along and cross the slopes provided with topographic survey proved the stability of contamination field (r=0, 915, n=121, r=0,912, n=30) and its relation to the meso- and microrelief features. Variation 137Cs activity in lateral direction (along the slopes and thalweg of the hollow)showed a regular character also. In our opinion the regularity in 137Cs spatial structure in the soil cover may result from radionuclide redistribution with the surface and subsurface water flow highly sensitive to the changes in elevation of different scale, and to the slope length and inclination. Cs-137 lateral distribution pattern was likely to reflect alternation of lateral and vertical water mass migration along the slopes. The performed study showing regularity in 137Cs redistribution seems to open new possibilities to develop the deterministic strategy in the study of contamination fields and modeling toxic elements spatial distribution in the soil cover on different scales. The authors are much obliged to Dr. V. Samsonov and Dr. F. Moiseenko for participation in the field work and to S. Kirov for the performance of the laboratory measurement of the soil and plant samples. References 1. Khomutinin, Yu.V., Kashparov, V.A., Zhebrovskaya, E.I., 2001. Optimization of sampling and measurement of the specimen for radioecological monitoring. UkrNIISKHR, Kiev. 2. Korobova, E.M., Romanov, S.L., Samsonov, V.L., Kirov, S.S., 2006. Experimental study of spatial 137Cs redistribution in paragenetic elementary landscapes, in: Kasimov, N.S. et al (Eds.), Geochemistry of biosphere (devoted to 90-th anniversary of A.I. Perelman), MSU, IGEM, RFFI, Moscow-Smolensk, pp.157-159. 3. Linnik, V.G., Saveliev, A.A., Govorun, A.P., Ivanitsky, O.M., Sokolov, A.V., 2006. Analysis of the Cs-137 contamination field on micro-landscape scale within the virgin meadows in the western part of the Bryansk region, in: Kasimov, N.S. et al (Eds.), Geochemistry of biosphere (devoted to 90-th anniversary of A.I. Perelman), MSU, IGEM, RFFI, Moscow-Smolensk, pp. 201-204. 4. Samsonova V.P. Spatial variability of the soil parameters. On example of soddy-podozolic soils. Moscow, LKI, 2008, 156 p. 5.Shcheglov, A.I., Tsvetnova, O.B., Klyashtorin, A.I., 2001. Biogeochemical migration of technogenic radionuclides in forest ecosystems. Nauka, Moscow.

Developmental Stability in Gender-Typed Preferences between Infancy and Preschool Age

ERIC Educational Resources Information Center

Lauer, Jillian E.; Ilksoy, Sibel D.; Lourenco, Stella F.

2018-01-01

Infants exhibit visual preferences for gender-typed objects (e.g., dolls, toy vehicles) that parallel the gender-typed play preferences of preschool-aged children, but the developmental stability of individual differences in early emerging gender-typed preferences has not yet been characterized. In the present study, we examined the longitudinal…

Thermally stable, plastic-bonded explosives

DOEpatents

Benziger, Theodore M.

1979-01-01

By use of an appropriate thermoplastic rubber as the binder, the thermal stability and thermal stress characteristics of plastic-bonded explosives may be greatly improved. In particular, an HMX-based explosive composition using an oil-extended styrene-ethylenebutylene-styrene block copolymer as the binder exhibits high explosive energy and thermal stability and good handling safety and physical properties.

Bication lead iodide 2D perovskite component to stabilize inorganic α-CsPbI3 perovskite phase for high-efficiency solar cells

PubMed Central

Zhang, Taiyang; Dar, M. Ibrahim; Li, Ge; Xu, Feng; Guo, Nanjie; Grätzel, Michael; Zhao, Yixin

2017-01-01

Among various all-inorganic halide perovskites exhibiting better stability than organic-inorganic halide perovskites, α-CsPbI3 with the most suitable band gap for tandem solar cell application faces an issue of phase instability under ambient conditions. We discovered that a small amount of two-dimensional (2D) EDAPbI4 perovskite containing the ethylenediamine (EDA) cation stabilizes the α-CsPbI3 to avoid the undesirable formation of the nonperovskite δ phase. Moreover, not only the 2D perovskite of EDAPbI4 facilitate the formation of α-CsPbI3 perovskite films exhibiting high phase stability at room temperature for months and at 100°C for >150 hours but also the α-CsPbI3 perovskite solar cells (PSCs) display highly reproducible efficiency of 11.8%, a record for all-inorganic lead halide PSCs. Therefore, using the bication EDA presents a novel and promising strategy to design all-inorganic lead halide PSCs with high performance and reliability. PMID:28975149

A facile construction of Au nanoparticles stabilized by thermo-responsive polymer-tethered carbon dots for enhanced catalytic performance

NASA Astrophysics Data System (ADS)

Li, Li; Zhang, Tianyi; Lü, Jianhua; Lü, Changli

2018-10-01

Carbon dots (CDs), the youngest member in the carbon nanomaterial family, have drawn considerable attention due to their interesting optical, physicochemical and electronic properties as well as broad promising applications. Here, we developed a facile and effective strategy for the preparation of Au nanoparticles stabilized by thermo-responsive poly(N-isopropylacrylamide) (PNIPAM) functionalized carbon dots (Au@CD@P) under the gentle water media. The as-designed dopamine(DA)-terminated PNIPAM can be easily anchored to CDs via mussel-inspired chemistry route. Both CD@P and CDs could well stabilize the Au nanoparticles with interesting assembled structure. The as-prepared Au@CD and Au@CD@P nanohybrids with good dispersibility and stability exhibited the intriguing catalytic activity for reduction of p-nitrophenol (p-NP). Especially, Au@CD@P as catalyst also played a switching role in regulating the catalytic rate by temperature. In addition, Au@CD@P exhibited excellent recyclability which may have potential in green chemical industry for developing high-activity catalysts and easy production methods.

Reynolds Number Effects on the Stability and Control Characteristics of a Supersonic Transport

NASA Technical Reports Server (NTRS)

Owens, L. R.; Wahls, R. A.; Elzey, M. B.; Hamner, M. P.

2002-01-01

A High Speed Civil Transport (HSCT) configuration was tested in the National Transonic Facility at the NASA Langley Research Center as part of NASA's High Speed Research Program. A series of tests included longitudinal and lateral/directional studies at transonic and low speed, high-lift conditions across a range of Reynolds numbers from that available in conventional wind tunnels to near flight conditions. Results presented focus on Reynolds number sensitivities of the stability and control characteristics at Mach 0.30 and 0.95 for a complete HSCT aircraft configuration including empennage. The angle of attack where the pitching-moment departure occurred increased with higher Reynolds numbers for both the landing and transonic configurations. The stabilizer effectiveness increased with Reynolds number for both configurations. The directional stability also increased with Reynolds number for both configurations. The landing configuration without forebody chines exhibited a large yawing-moment departure at high angles of attack and zero sideslip that varied with increasing Reynolds numbers. This departure characteristic nearly disappeared when forebody chines were added. The landing configuration's rudder effectiveness also exhibited sensitivities to changes in Reynolds number.

P53 nuclear stabilization is associated with FHIT loss and younger age of onset in squamous cell carcinoma of oral tongue

PubMed Central

2014-01-01

Background Squamous cell carcinoma of tongue (SCCT) is expected to harbor unique clinico-pathological and molecular genetic features since a significant proportion of patients are young and exhibit no association with tobacco or alcohol. Methods We determined P53, epidermal growth factor receptor, microsatellite instability, human papilloma virus infection and loss of heterozygosity status at several tumor suppressor loci in one hundred and twenty one oral SCCT (SSCOT) samples and analyzed their association with clinico-pathological features and patient survival. Results Our results revealed a significantly higher incidence of p53 nuclear stabilization in early (as against late) onset SCCOT. FHIT loss was significantly associated with p53 nuclear stabilization and the association was stronger in patients with no history of tobacco use. Samples harboring mutation in p53 DNA binding domain or exhibiting p53 nuclear stabilization, were significantly associated with poor survival. Conclusion Our study has therefore identified distinct features in SCCOT tumorigenesis with respect to age and tobacco exposure and revealed possible prognostic utility of p53. PMID:25152695

Effect of whey protein isolate and β-cyclodextrin wall systems on stability of microencapsulated vanillin by spray-freeze drying method.

PubMed

Hundre, Swetank Y; Karthik, P; Anandharamakrishnan, C

2015-05-01

Vanillin flavour is highly volatile in nature and due to that application in food incorporation is limited; hence microencapsulation of vanillin is an ideal technique to increase its stability and functionality. In this study, vanillin was microencapsulated for the first time by non-thermal spray-freeze-drying (SFD) technique and its stability was compared with other conventional techniques such as spray drying (SD) and freeze-drying (FD). Different wall materials like β-cyclodextrin (β-cyd), whey protein isolate (WPI) and combinations of these wall materials (β-cyd + WPI) were used to encapsulate vanillin. SFD microencapsulated vanillin with WPI showed spherical shape with numerous fine pores on the surface, which in turn exhibited good rehydration ability. On the other hand, SD powder depicted spherical shape without pores and FD encapsulated powder yielded larger particle sizes with flaky structure. FTIR analysis confirmed that there was no interaction between vanillin and wall materials. Moreover, spray-freeze-dried vanillin + WPI sample exhibited better thermal stability than spray dried and freeze-dried microencapsulated samples. Copyright © 2014 Elsevier Ltd. All rights reserved.

Perovskite Solar Cells with Inorganic Electron- and Hole-Transport Layers Exhibiting Long-Term (≈500 h) Stability at 85 °C under Continuous 1 Sun Illumination in Ambient Air.

PubMed

Seo, Seongrok; Jeong, Seonghwa; Bae, Changdeuck; Park, Nam-Gyu; Shin, Hyunjung

2018-05-22

Despite the high power conversion efficiency (PCE) of perovskite solar cells (PSCs), poor long-term stability is one of the main obstacles preventing their commercialization. Several approaches to enhance the stability of PSCs have been proposed. However, an accelerating stability test of PSCs at high temperature under the operating conditions in ambient air remains still to be demonstrated. Herein, interface-engineered stable PSCs with inorganic charge-transport layers are shown. The highly conductive Al-doped ZnO films act as efficient electron-transporting layers as well as dense passivation layers. This layer prevents underneath perovskite from moisture contact, evaporation of components, and reaction with a metal electrode. Finally, inverted-type PSCs with inorganic charge-transport layers exhibit a PCE of 18.45% and retain 86.7% of the initial efficiency for 500 h under continuous 1 Sun illumination at 85 °C in ambient air with electrical biases (at maximum power point tracking). © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Enhanced thermal stability of RuO2/polyimide interface for flexible device applications

NASA Astrophysics Data System (ADS)

Music, Denis; Schmidt, Paul; Chang, Keke

2017-09-01

We have studied the thermal stability of RuO2/polyimide (Kapton) interface using experimental and theoretical methods. Based on calorimetric and spectroscopic analyses, this inorganic-organic system does not exhibit any enthalpic peaks as well as all bonds in RuO2 and Kapton are preserved up to 500 °C. In addition, large-scale density functional theory based molecular dynamics, carried out in the same temperature range, validates the electronic structure and points out that numerous Ru-C and a few Ru-O covalent/ionic bonds form across the RuO2/Kapton interface. This indicates strong adhesion, but there is no evidence of Kapton degradation upon thermal excitation. Furthermore, RuO2 does not exhibit any interfacial bonds with N and H in Kapton, providing additional evidence for the thermal stability notion. It is suggested that the RuO2/Kapton interface is stable due to aromatic architecture of Kapton. This enhanced thermal stability renders Kapton an appropriate polymeric substrate for RuO2 containing systems in various applications, especially for flexible microelectronic and energy devices.

Failure criterion for materials with spatially correlated mechanical properties

NASA Astrophysics Data System (ADS)

Faillettaz, J.; Or, D.

2015-03-01

The role of spatially correlated mechanical elements in the failure behavior of heterogeneous materials represented by fiber bundle models (FBMs) was evaluated systematically for different load redistribution rules. Increasing the range of spatial correlation for FBMs with local load sharing is marked by a transition from ductilelike failure characteristics into brittlelike failure. The study identified a global failure criterion based on macroscopic properties (external load and cumulative damage) that is independent of spatial correlation or load redistribution rules. This general metric could be applied to assess the mechanical stability of complex and heterogeneous systems and thus provide an important component for early warning of a class of geophysical ruptures.

Brief report: visual-spatial deficit in a 16-year-old girl with maternally derived duplication of proximal 15q.

PubMed

Cohen, David; Martel, Claire; Wilson, Anna; Déchambre, Nicole; Amy, Céline; Duverger, Ludovic; Guile, Jean-Marc; Pipiras, Eva; Benzacken, Brigitte; Cavé, Hélène; Cohen, Laurent; Héron, Delphine; Plaza, Monique

2007-09-01

Duplications of chromosome 15 may be one of the most common single genetic causes of autism spectrum disorders (ASD), aside from fragile X. Most of the cases are associated with maternally derived interstitial duplication involving 15q11-13. This case report describes a female proband with a maternally derived interstitial duplication of proximal 15q. She did not exhibit any symptoms of ASD apart from some developmental delay. By adolescence, she showed mild dysmorphism, a discrepant profile on the Wechsler Intelligence Scale for Children (Verbal IQ = 87; Performance IQ = 65) and a major deficit in visual-spatial abilities affecting fine motor skills, mathematical reasoning, visual memory and some global reading tasks. This is one of the first reports of a child with a maternal duplication who exhibits a visual-spatial deficit without ASD.

Time-varying correlations in global real estate markets: A multivariate GARCH with spatial effects approach

NASA Astrophysics Data System (ADS)

Gu, Huaying; Liu, Zhixue; Weng, Yingliang

2017-04-01

The present study applies the multivariate generalized autoregressive conditional heteroscedasticity (MGARCH) with spatial effects approach for the analysis of the time-varying conditional correlations and contagion effects among global real estate markets. A distinguishing feature of the proposed model is that it can simultaneously capture the spatial interactions and the dynamic conditional correlations compared with the traditional MGARCH models. Results reveal that the estimated dynamic conditional correlations have exhibited significant increases during the global financial crisis from 2007 to 2009, thereby suggesting contagion effects among global real estate markets. The analysis further indicates that the returns of the regional real estate markets that are in close geographic and economic proximities exhibit strong co-movement. In addition, evidence of significantly positive leverage effects in global real estate markets is also determined. The findings have significant implications on global portfolio diversification opportunities and risk management practices.

A Carbon-Cotton Cathode with Ultrahigh-Loading Capability for Statically and Dynamically Stable Lithium–Sulfur Batteries

DOE PAGES

Chung, Sheng-Heng; Chang, Chi-Hao; Manthiram, Arumugam

2016-10-26

Sulfur exhibits a high theoretical capacity of 1675 mA h g -1 via a distinct conversion reaction, which is different from the insertion reactions in commercial lithium-ion batteries. In consideration of its conversion reaction battery chemistry, a custom design for electrode materials could establish the way for attaining high-loading capability while simultaneously maintaining high electrochemical utilization and stability. In this study, this process is undertaken by introducing carbon cotton as an attractive electrode-containment material for enhancing the dynamic and static stabilities of lithium-sulfur (Li-S) batteries. The carbon cotton possessing a hierarchical macro-/microporous architecture exhibits a high surface area of 805more » m 2 g -1 and high microporosity with a micropore area of 557 m 2 g -1. The macroporous channels allow the carbon cotton to load and stabilize a high amount of active material. The abundant microporous reaction sites spread throughout the carbon cotton facilitate the redox chemistry of the high-loading/content Li-S system. As a result, the high-loading carbon-cotton cathode exhibits (i) enhanced cycle stability with a good dynamic capacity retention of 70% after 100 cycles and (ii) improved cellstorage stability with a high static capacity retention of above 93% and a low time-dependent self-discharge rate of 0.12% per day after storing for a long period of 60 days. In conclusion, these carbon-cotton cathodes with the remarkably highest values reported so far of both sulfur loading (61.4 mg cm -2) and sulfur content (80 wt %) demonstrate enhanced electrochemical utilization with the highest areal, volumetric, and gravimetric capacities simultaneously.« less

A Carbon-Cotton Cathode with Ultrahigh-Loading Capability for Statically and Dynamically Stable Lithium–Sulfur Batteries

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chung, Sheng-Heng; Chang, Chi-Hao; Manthiram, Arumugam

Sulfur exhibits a high theoretical capacity of 1675 mA h g -1 via a distinct conversion reaction, which is different from the insertion reactions in commercial lithium-ion batteries. In consideration of its conversion reaction battery chemistry, a custom design for electrode materials could establish the way for attaining high-loading capability while simultaneously maintaining high electrochemical utilization and stability. In this study, this process is undertaken by introducing carbon cotton as an attractive electrode-containment material for enhancing the dynamic and static stabilities of lithium-sulfur (Li-S) batteries. The carbon cotton possessing a hierarchical macro-/microporous architecture exhibits a high surface area of 805more » m 2 g -1 and high microporosity with a micropore area of 557 m 2 g -1. The macroporous channels allow the carbon cotton to load and stabilize a high amount of active material. The abundant microporous reaction sites spread throughout the carbon cotton facilitate the redox chemistry of the high-loading/content Li-S system. As a result, the high-loading carbon-cotton cathode exhibits (i) enhanced cycle stability with a good dynamic capacity retention of 70% after 100 cycles and (ii) improved cellstorage stability with a high static capacity retention of above 93% and a low time-dependent self-discharge rate of 0.12% per day after storing for a long period of 60 days. In conclusion, these carbon-cotton cathodes with the remarkably highest values reported so far of both sulfur loading (61.4 mg cm -2) and sulfur content (80 wt %) demonstrate enhanced electrochemical utilization with the highest areal, volumetric, and gravimetric capacities simultaneously.« less

Synthesis and Performance of Highly Stable Star-Shaped Polyaniline Electrochromic Materials with Triphenylamine Core

NASA Astrophysics Data System (ADS)

Xiong, Shanxin; Li, Shuaishuai; Zhang, Xiangkai; Wang, Ru; Zhang, Runlan; Wang, Xiaoqin; Wu, Bohua; Gong, Ming; Chu, Jia

2018-02-01

The molecular architecture of conducting polymers has a significant impact on their conjugated structure and electrochemical properties. We have investigated the influence of star-shaped structure on the electrochemical and electrochromic properties of polyaniline (PANI). Star-shaped PANI (SPANI) was prepared by copolymerization of aniline with triphenylamine (TPA) using an emulsion polymerization method. With addition of less than 4.0 mol.% TPA, the resulting SPANI exhibited good solubility in xylene with dodecylbenzenesulfonic acid (DBSA) as doping acid. The structure and thermal stability of the SPANI were characterized using Fourier-transform infrared spectroscopy, Raman spectroscopy, and thermogravimetric analysis, and the electrochemical behavior was analyzed by cyclic voltammetry (CV). The electrochromic properties of SPANI were tested using an electrochemical workstation combined with an ultraviolet-visible (UV-Vis) spectrometer. The results show that, with increasing TPA loading, the thermal stability of SPANI increased. With addition of 4.0 mol.% TPA, the weight loss of SPANI was 36.9% at 700°C, much lower than the value of 71.2% for PANI at the same temperature. The low oxidation potential and large enclosed area of the CV curves indicate that SPANI possesses higher electrochemical activity than PANI. Enhanced electrochromic properties including higher optical contrast and better electrochromic stability of SPANI were also obtained. SPANI with 1.6 mol.% TPA loading exhibited the highest optical contrast of 0.71, higher than the values of 0.58 for PANI, 0.66 for SPANI-0.4%, or 0.63 for SPANI-4.0%. Overdosing of TPA resulted in slow switching speed due to slow ion transport in short branched chains of star-shaped PANI electrochromic material. Long-term stability testing confirmed that all the SPANI-based devices exhibited better stability than the PANI-based device.

Long term stability of nanowire nanoelectronics in physiological environments.

PubMed

Zhou, Wei; Dai, Xiaochuan; Fu, Tian-Ming; Xie, Chong; Liu, Jia; Lieber, Charles M

2014-03-12

Nanowire nanoelectronic devices have been exploited as highly sensitive subcellular resolution detectors for recording extracellular and intracellular signals from cells, as well as from natural and engineered/cyborg tissues, and in this capacity open many opportunities for fundamental biological research and biomedical applications. Here we demonstrate the capability to take full advantage of the attractive capabilities of nanowire nanoelectronic devices for long term physiological studies by passivating the nanowire elements with ultrathin metal oxide shells. Studies of Si and Si/aluminum oxide (Al2O3) core/shell nanowires in physiological solutions at 37 °C demonstrate long-term stability extending for at least 100 days in samples coated with 10 nm thick Al2O3 shells. In addition, investigations of nanowires configured as field-effect transistors (FETs) demonstrate that the Si/Al2O3 core/shell nanowire FETs exhibit good device performance for at least 4 months in physiological model solutions at 37 °C. The generality of this approach was also tested with in studies of Ge/Si and InAs nanowires, where Ge/Si/Al2O3 and InAs/Al2O3 core/shell materials exhibited stability for at least 100 days in physiological model solutions at 37 °C. In addition, investigations of hafnium oxide-Al2O3 nanolaminated shells indicate the potential to extend nanowire stability well beyond 1 year time scale in vivo. These studies demonstrate that straightforward core/shell nanowire nanoelectronic devices can exhibit the long term stability needed for a range of chronic in vivo studies in animals as well as powerful biomedical implants that could improve monitoring and treatment of disease.

Long Term Stability of Nanowire Nanoelectronics in Physiological Environments

PubMed Central

2015-01-01

Nanowire nanoelectronic devices have been exploited as highly sensitive subcellular resolution detectors for recording extracellular and intracellular signals from cells, as well as from natural and engineered/cyborg tissues, and in this capacity open many opportunities for fundamental biological research and biomedical applications. Here we demonstrate the capability to take full advantage of the attractive capabilities of nanowire nanoelectronic devices for long term physiological studies by passivating the nanowire elements with ultrathin metal oxide shells. Studies of Si and Si/aluminum oxide (Al2O3) core/shell nanowires in physiological solutions at 37 °C demonstrate long-term stability extending for at least 100 days in samples coated with 10 nm thick Al2O3 shells. In addition, investigations of nanowires configured as field-effect transistors (FETs) demonstrate that the Si/Al2O3 core/shell nanowire FETs exhibit good device performance for at least 4 months in physiological model solutions at 37 °C. The generality of this approach was also tested with in studies of Ge/Si and InAs nanowires, where Ge/Si/Al2O3 and InAs/Al2O3 core/shell materials exhibited stability for at least 100 days in physiological model solutions at 37 °C. In addition, investigations of hafnium oxide-Al2O3 nanolaminated shells indicate the potential to extend nanowire stability well beyond 1 year time scale in vivo. These studies demonstrate that straightforward core/shell nanowire nanoelectronic devices can exhibit the long term stability needed for a range of chronic in vivo studies in animals as well as powerful biomedical implants that could improve monitoring and treatment of disease. PMID:24479700

Stabilization of Live Attenuated Influenza Vaccines by Freeze Drying, Spray Drying, and Foam Drying.

PubMed

Lovalenti, Phillip M; Anderl, Jeff; Yee, Luisa; Nguyen, Van; Ghavami, Behnaz; Ohtake, Satoshi; Saxena, Atul; Voss, Thomas; Truong-Le, Vu

2016-05-01

The goal of this research is to develop stable formulations for live attenuated influenza vaccines (LAIV) by employing the drying methods freeze drying, spray drying, and foam drying. Formulated live attenuated Type-A H1N1 and B-strain influenza vaccines with a variety of excipient combinations were dried using one of the three drying methods. Process and storage stability at 4, 25 and 37°C of the LAIV in these formulations was monitored using a TCID50 potency assay. Their immunogenicity was also evaluated in a ferret model. The thermal stability of H1N1 vaccine was significantly enhanced through application of unique formulation combinations and drying processes. Foam dried formulations were as much as an order of magnitude more stable than either spray dried or freeze dried formulations, while exhibiting low process loss and full retention of immunogenicity. Based on long-term stability data, foam dried formulations exhibited a shelf life at 4, 25 and 37°C of >2, 1.5 years and 4.5 months, respectively. Foam dried LAIV Type-B manufactured using the same formulation and process parameters as H1N1 were imparted with a similar level of stability. Foam drying processing methods with appropriate selection of formulation components can produce an order of magnitude improvement in LAIV stability over other drying methods.

One stone, two birds: silica nanospheres significantly increase photocatalytic activity and colloidal stability of photocatalysts

NASA Astrophysics Data System (ADS)

Rasamani, Kowsalya D.; Foley, Jonathan J., IV; Sun, Yugang

2018-03-01

Silver-doped silver chloride [AgCl(Ag)] nanoparticles represent a unique class of visible-light-driven photocatalysts, in which the silver dopants introduce electron-abundant mid-gap energy levels to lower the bandgap of AgCl. However, free-standing AgCl(Ag) nanoparticles, particularly those with small sizes and large surface areas, exhibit low colloidal stability and low compositional stability upon exposure to light irradiation, leading to easy aggregation and conversion to metallic silver and thus a loss of photocatalytic activity. These problems could be eliminated by attaching the small AgCl(Ag) nanoparticles to the surfaces of spherical dielectric silica particles with submicrometer sizes. The high optical transparency in the visible spectral region (400-800 nm), colloidal stability, and chemical/electronic inertness displayed by the silica spheres make them ideal for supporting photocatalysts and significantly improving their stability. The spherical morphology of the dielectric silica particles can support light scattering resonances to generate significantly enhanced electric fields near the silica particle surfaces, on which the optical absorption cross-section of the AgCl(Ag) nanoparticles is dramatically increased to promote their photocatalytic activity. The hybrid silica/AgCl(Ag) structures exhibit superior photocatalytic activity and stability, suitable for supporting photocatalysis sustainably; for instance, their efficiency in the photocatalytic decomposition of methylene blue decreases by only ˜9% even after ten cycles of operation.

Cortisol reactivity to stress among youth: Stability over time and genetic variants for stress sensitivity

PubMed Central

Hankin, Benjamin L.; Badanes, Lisa S.; Smolen, Andrew; Young, Jami F.

2015-01-01

Stress sensitivity may be one process that can explain why some genetically at-risk individuals are more susceptible to some types of stress-reactive psychopathologies. Dysregulation of the Limbic Hypothalamic Pituitary Adrenal (LHPA) axis, including cortisol reactivity to challenge, represents a key aspect of stress sensitivity. However, the degree of stability over time among youth, especially differential stability as a function of particular genetic variants, has not been investigated. A general community sample of children and adolescents (mean age = 11.4; 56% girls) provided a DNA sample and completed two separate laboratory stress challenges, across an 18-month follow-up (N =224 at Time 1; N = 194 at Time 2), with repeated measures of salivary cortisol. Results showed that test-retest stability for several indices of cortisol reactivity across the laboratory challenge visits were significant and of moderate magnitude for the whole sample. Moreover, gene variants of several biologically plausible systems relevant for stress sensitivity (especially 5-HTTLPR and CRHR1) demonstrated differential stability of cortisol reactivity over 18-months, such that carriers of genotypes conferring enhanced environmental susceptibility exhibited greater stability of cortisol levels over time for some LHPA axis indices. Findings suggest that LHPA axis dysregulation may exhibit some trait-like aspects underlying stress sensitivity in youth, especially for those who carry genes related to greater genetic susceptibility to environmental stress. PMID:25688432

Impact factors identification of spatial heterogeneity of herbaceous plant diversity on five southern islands of Miaodao Archipelago in North China

NASA Astrophysics Data System (ADS)

Chi, Yuan; Shi, Honghua; Wang, Xiaoli; Qin, Xuebo; Zheng, Wei; Peng, Shitao

2016-09-01

Herbaceous plants are widely distributed on islands and where they exhibit spatial heterogeneity. Accurately identifying the impact factors that drive spatial heterogeneity can reveal typical island biodiversity patterns. Five southern islands in the Miaodao Archipelago, North China were studied herein. The spatial distribution of herbaceous plant diversity on these islands was analyzed, and the impact factors and their degree of impact on spatial heterogeneity were identified using CCA ordination and ANOVA. The results reveal 114 herbaceous plant species, belonging to 94 genera from 34 families in the 50 plots sampled. The total species numbers on different islands were significantly positively correlated with island area, and the average α diversity was correlated with human activities, while the β diversity among islands was more affected by island area than mutual distances. Spatial heterogeneity within islands indicated that the diversities were generally high in areas with higher altitude, slope, total nitrogen, total carbon, and canopy density, and lower moisture content, pH, total phosphorus, total potassium, and aspect. Among the environmental factors, pH, canopy density, total K, total P, moisture content, altitude, and slope had significant gross effects, but only canopy density exhibited a significant net effect. Terrain affected diversity by restricting plantation, plantation in turn influenced soil properties and the two together affected diversity. Therefore, plantation was ultimately the fundamental driving factor for spatial heterogeneity in herbaceous plant diversity on the five islands.

Spatial Acuity and Prey Detection in Weakly Electric Fish

PubMed Central

Babineau, David; Lewis, John E; Longtin, André

2007-01-01

It is well-known that weakly electric fish can exhibit extreme temporal acuity at the behavioral level, discriminating time intervals in the submicrosecond range. However, relatively little is known about the spatial acuity of the electrosense. Here we use a recently developed model of the electric field generated by Apteronotus leptorhynchus to study spatial acuity and small signal extraction. We show that the quality of sensory information available on the lateral body surface is highest for objects close to the fish's midbody, suggesting that spatial acuity should be highest at this location. Overall, however, this information is relatively blurry and the electrosense exhibits relatively poor acuity. Despite this apparent limitation, weakly electric fish are able to extract the minute signals generated by small prey, even in the presence of large background signals. In fact, we show that the fish's poor spatial acuity may actually enhance prey detection under some conditions. This occurs because the electric image produced by a spatially dense background is relatively “blurred” or spatially uniform. Hence, the small spatially localized prey signal “pops out” when fish motion is simulated. This shows explicitly how the back-and-forth swimming, characteristic of these fish, can be used to generate motion cues that, as in other animals, assist in the extraction of sensory information when signal-to-noise ratios are low. Our study also reveals the importance of the structure of complex electrosensory backgrounds. Whereas large-object spacing is favorable for discriminating the individual elements of a scene, small spacing can increase the fish's ability to resolve a single target object against this background. PMID:17335346

Inter-specific territoriality in a Canis hybrid zone: spatial segregation between wolves, coyotes, and hybrids.

PubMed

Benson, John F; Patterson, Brent R

2013-12-01

Gray wolves (Canis lupus) and coyotes (Canis latrans) generally exhibit intraspecific territoriality manifesting in spatial segregation between adjacent packs. However, previous studies have found a high degree of interspecific spatial overlap between sympatric wolves and coyotes. Eastern wolves (Canis lycaon) are the most common wolf in and around Algonquin Provincial Park (APP), Ontario, Canada and hybridize with sympatric gray wolves and coyotes. We hypothesized that all Canis types (wolves, coyotes, and hybrids) exhibit a high degree of spatial segregation due to greater genetic, morphologic, and ecological similarities between wolves and coyotes in this hybrid system compared with western North American ecosystems. We used global positioning system telemetry and probabilistic measures of spatial overlap to investigate spatial segregation between adjacent Canis packs. Our hypothesis was supported as: (1) the probability of locating wolves, coyotes, and hybrids within home ranges ([Formula: see text] = 0.05) or core areas ([Formula: see text] < 0.01) of adjacent packs was low; and (2) the amount of shared space use was negligible. Spatial segregation did not vary substantially in relation to genotypes of adjacent packs or local environmental conditions (i.e., harvest regulations or road densities). We provide the first telemetry-based demonstration of spatial segregation between wolves and coyotes, highlighting the novel relationships between Canis types in the Ontario hybrid zone relative to areas where wolves and coyotes are reproductively isolated. Territoriality among Canis may increase the likelihood of eastern wolves joining coyote and hybrid packs, facilitate hybridization, and could play a role in limiting expansion of the genetically distinct APP eastern wolf population.

Effect of Action Video Games on the Spatial Distribution of Visuospatial Attention

ERIC Educational Resources Information Center

Green, C. Shawn; Bavelier, Daphne

2006-01-01

The authors investigated the effect of action gaming on the spatial distribution of attention. The authors used the flanker compatibility effect to separately assess center and peripheral attentional resources in gamers versus nongamers. Gamers exhibited an enhancement in attentional resources compared with nongamers, not only in the periphery but…

Aqueous clay suspensions stabilized by alginate fluid gels for coal spontaneous combustion prevention and control.

PubMed

Qin, Botao; Ma, Dong; Li, Fanglei; Li, Yong

2017-11-01

We have developed aqueous clay suspensions stabilized by alginate fluid gels (AFG) for coal spontaneous combustion prevention and control. Specially, this study aimed to characterize the effect of AFG on the microstructure, static and dynamic stability, and coal fire inhibition performances of the prepared AFG-stabilized clay suspensions. Compared with aqueous clay suspensions, the AFG-stabilized clay suspensions manifest high static and dynamic stability, which can be ascribed to the formation of a robust three-dimensional gel network by AFG. The coal acceleration oxidation experimental results show that the prepared AFG-stabilized clay suspensions can improve the coal thermal stability and effectively inhibit the coal spontaneous oxidation process by increasing crossing point temperature (CPT) and reducing CO emission. The prepared low-cost and nontoxic AFG-stabilized clay suspensions, exhibiting excellent coal fire extinguishing performances, indicate great application potentials in coal spontaneous combustion prevention and control.

Energetics of the Brazil Current in the Rio Grande Cone region

NASA Astrophysics Data System (ADS)

Brum, André Lopes; Azevedo, José Luiz Lima de; Oliveira, Leopoldo Rota de; Calil, Paulo Henrique Rezende

2017-10-01

The energetics of the Brazil Current (BC) in the region of the Rio Grande Cone (RGC, 30-35.5°S), a topographic rise in the southwest portion of the Brazilian continental margin, are analyzed using 16 years of numerical data from the Ocean General Circulation Model (OGCM) for the Earth Simulator (OFES). The main focus of this study is the eddy-mean flow interactions of the BC and the local energy budgets in the study region. The kinetic and potential energy balance equations are derived for mean and eddy flows, and the resulting terms are presented and discussed. The eddy-mean flow interactions exhibit complex spatial distributions, and the intensities of the energy budgets decrease with increasing depth. However, only the mean potential energy (MPE) budget decreases southward. Eddy kinetic energy (EKE) and eddy potential energy (EPE) exhibit similar horizontal distribution patterns. Additionally, the baroclinic and barotropic conversion rates increase downstream of the bump, where the eddy energy field exhibits along-stream variability that increases southward. Barotropic conversion is more intense between 50 and 200 m, where mean kinetic energy (MKE) and EKE are concentrated, and it exhibits a horizontal cross-stream variation pattern, with mean-to-eddy energy conversion observed on the offshore side of the BC. This result indicates that the turbulence associated with the stream jet increases as the BC moves away from the coast, with the conversion term acting to stabilize the flow. Baroclinic conversion exhibits a high intensity below 300 m (where MPE and EPE display peaks), and it has a greater influence on the eddy-mean flow interaction than does the barotropic conversion. The RGC directly affects the local dynamics of the BC by increasing the eddy field as soon as the BC reaches the bump. The energy diagrams illustrate a stream characterized by evolving barotropic and baroclinic instability processes throughout the water column. This result indicates an intrinsically unstable jet in the study region. Moreover, baroclinic instability is the main source of EKE in the RGC region.

Toxoplasma gondii strain-dependent effects on mouse behaviour.

PubMed

Kannan, Geetha; Moldovan, Krisztina; Xiao, Jian-Chun; Yolken, Robert H; Jones-Brando, Lorraine; Pletnikov, Mikhail V

2010-06-01

Toxoplasma gondii reportedly manipulates rodent behaviour to increase transmission to its definitive feline host. We compared the effects of mouse infection by two Type II strains of T. gondii, Prugniaud (PRU) and ME49, on attraction to cat odour, locomotor activity, anxiety, sensorimotor gating, and spatial working and recognition memory 2 months post-infection (mpi). Attraction to cat odour was reassessed 7 mpi. At 2 mpi, mice infected with either strain exhibited significantly more attraction to cat odour than uninfected animals did, but only PRU-infected mice exhibited this behaviour 7 mpi. PRU-infected mice had significantly greater body weights and hyperactivity, while ME49-infected mice exhibited impaired spatial working memory. No differences in parasite antibody titres were seen between PRU- and ME49-infected mice. The present data suggest the effect of T. gondii infection on mouse behaviour is parasite strain-dependent.

Phase stabilization of multidimensional amplification architectures for ultrashort pulses

NASA Astrophysics Data System (ADS)

Müller, M.; Kienel, M.; Klenke, A.; Eidam, T.; Limpert, J.; Tünnermann, A.

2015-03-01

The active phase stabilization of spatially and temporally combined ultrashort pulses is investigated theoretically and experimentally. Particularly, considering a combining scheme applying 2 amplifier channels and 4 divided-pulse replicas a bistable behavior is observed. The reason is mutual influence of the optical error signals that is intrinsic to temporal polarization beam combining. A successful mitigation strategy is proposed and is analyzed theoretically and experimentally.

Stability of the thermodynamic equilibrium - A test of the validity of dynamic models as applied to gyroviscous perpendicular magnetohydrodynamics

NASA Astrophysics Data System (ADS)

Faghihi, Mustafa; Scheffel, Jan; Spies, Guenther O.

1988-05-01

Stability of the thermodynamic equilibrium is put forward as a simple test of the validity of dynamic equations, and is applied to perpendicular gyroviscous magnetohydrodynamics (i.e., perpendicular magnetohydrodynamics with gyroviscosity added). This model turns out to be invalid because it predicts exponentially growing Alfven waves in a spatially homogeneous static equilibrium with scalar pressure.

Coastal fog and low cloud spatial patterns: do they indicate potential biodiversity refugia?

NASA Astrophysics Data System (ADS)

Torregrosa, A.

2016-12-01

Marine fog and low clouds transfer water and nutrients to coastal ecosystems through advection from the ocean and reduce heat effects by reflecting incoming shortwave radiation. These effects are known to benefit many species, vegetation communities, and habitats such as coastal redwood trees and their understory, maritime chaparral, and coastal streams harboring endangered salmon species. The California floristic region is the highest ranked hotspot in the U.S. and ranked 7th of 35 biodiversity hotspots worldwide in terms of the percent of its plant species that are found nowhere else (endemic). Many environmental drivers have been identified as contributing to California's remarkably high endemism and biodiversity, however, coastal low clouds have not typically been included. This could be due to the lack of data such as high resolution maps of coastal low cloud occurrence or the lack of long term records. Using a recent analysis of hourly National Weather Service satellite data, a stability index (SI) for coastal fog and low cloud cover was derived using two measures of variation and average summertime cloud cover to quantify long term spatial stability trends. Several discrete spatial clumps were identified that had both high temporal stability and high coastal low cloud cover. These areas show a strong correlation with a specific topographic landscape configuration with respect to wind direction. Point occurrence distribution maps of endemic coastal species were overlain with the SI to explore spatial correlation. The federally endangered species that showed very high spatial correlation included Yadon's Rein-orchid (Piperia yadonii), Monterey Spineflower (Chorizanthe pungens var. pungens), and Seaside Bird's-beak (Cordylanthus rigidus ssp. littoralis). Current estimated range maps are not consistent with the SI results suggesting a need to update estimated ranges. Biodiversity measures are being investigated in these areas to explore the hypothesis that they can be considered paleorefugia for species that have persisted over millennia in spite of a general increase in the aridity and temperature of the California climate.

Effects of Laboratory Disinfecting Agents on Dimensional Stability of Three Commercially Available Heat-Cured Denture Acrylic Resins in India: An In-Vitro Study

PubMed Central

Jujare, Ravikanth Haridas; Varghese, Rana Kalappattil; Singh, Vishwa Deepak; Gaurav, Amit

2016-01-01

Introduction Dental professionals are exposed to a wide variety of microorganisms which calls for use of effective infection control procedures in the dental office and laboratories that can prevent cross-contamination that could extend to dentists, dental office staff, dental technicians as well as patients. This concern has led to a renewed interest in denture sterilization and disinfection. Heat polymerized dentures exhibit dimensional change during disinfection procedure. Aim The purpose of this study was to determine the influence of different types of widely used laboratory disinfecting agents on the dimensional stability of heat-cured denture acrylic resins and to compare the dimensional stability of three commercially available heat-cured denture acrylic resins in India. Materials and Methods Twelve specimens of uniform dimension each of three different brands namely Stellon, Trevalon and Acralyn-H were prepared using circular metal disc. Chemical disinfectants namely 2% alkaline glutaraldehyde, 1% povidone-iodine, 0.5% sodium hypochlorite and water as control group were used. Diameter of each specimen was measured before immersion and after immersion with time interval of 1 hour and 12 hours. The data was evaluated statistically using one way analysis of variance. Results All the specimens in three disinfectants and in water exhibited very small amount of linear expansion. Among three disinfectants, specimens in 2% alkaline glutaraldehyde exhibited least(0.005mm) and water showed highest (0.009mm) amount of dimensional change. Among resins, Trevalon showed least (0.067mm) and Acralyn-H exhibited highest (0.110mm) amount of dimensional change. Conclusion Although, all the specimens of three different brands of heat-cured denture acrylic resins exhibited increase in linear dimensional change in all the disinfectants and water, they were found to be statistically insignificant. PMID:27134996

Spatiotemporal dynamics of the spin transition in [Fe (HB(tz)3) 2] single crystals

NASA Astrophysics Data System (ADS)

Ridier, Karl; Rat, Sylvain; Shepherd, Helena J.; Salmon, Lionel; Nicolazzi, William; Molnár, Gábor; Bousseksou, Azzedine

2017-10-01

The spatiotemporal dynamics of the spin transition have been thoroughly investigated in single crystals of the mononuclear spin-crossover (SCO) complex [Fe (HB (tz )3)2] (tz = 1 ,2 ,4-triazol-1-yl) by optical microscopy. This compound exhibits an abrupt spin transition centered at 334 K with a narrow thermal hysteresis loop of ˜1 K (first-order transition). Most single crystals of this compound reveal exceptional resilience upon repeated switching (several hundred cycles), which allowed repeatable and quantitative measurements of the spatiotemporal dynamics of the nucleation and growth processes to be carried out. These experiments revealed remarkable properties of the thermally induced spin transition: high stability of the thermal hysteresis loop, unprecedented large velocities of the macroscopic low-spin/high-spin phase boundaries up to 500 µm/s, and no visible dependency on the temperature scan rate. We have also studied the dynamics of the low-spin → high-spin transition induced by a local photothermal excitation generated by a spatially localized (Ø = 2 μ m ) continuous laser beam. Interesting phenomena have been evidenced both in quasistatic and dynamic conditions (e.g., threshold effects and long incubation periods, thermal activation of the phase boundary propagation, stabilization of the crystal in a stationary biphasic state, and thermal cutoff frequency). These measurements demonstrated the importance of thermal effects in the transition dynamics, and they enabled an accurate determination of the thermal properties of the SCO compound in the framework of a simple theoretical model.

Yb-fiber-pumped mid-infrared picosecond optical parametric oscillator tunable across 6.2-6.7 µm

NASA Astrophysics Data System (ADS)

Kumar, S. Chaitanya; Casals, J. Canals; Parsa, S.; Zawilski, K. T.; Schunemann, P. G.; Ebrahim-Zadeh, M.

2018-06-01

We report a high-average-power picosecond optical parametric oscillator (OPO) tunable in the mid-infrared (mid-IR) based on CdSiP2 synchronously pumped by an Yb-fiber laser at 80 MHz repetition rate. Successful operation of this high-repetition-rate singly-resonant picosecond OPO has been enabled by the improved CSP crystal quality over a long interaction length. The OPO can be tuned across 1264-1284 nm in the near-IR signal and 6205-6724 nm in the mid-IR idler by temperature tuning the CSP crystal over 39-134 °C. By deploying a 5% output coupler for the resonant signal, we have extracted up to 44 mW of average power in the near-IR and up to 95 mW of non-resonant idler power at 6205 nm at 6.3% total conversion efficiency, with > 50 mW over > 55% of the mid-IR tuning range. We have investigated temperature-tuning characteristics of the OPO and compared the data with the theoretical calculations using the recent Sellmeier and thermo-optic coefficients for CdSiP2. The signal pulses from the OPO exhibit a Gaussian pulse duration of 19 ps centered at 1284 nm. We have also studied the output power stability of the OPO, resulting in a passive stability better than 1.9% rms for the near-IR signal and 2.4% rms for the mid-IR idler, measured over > 17 h, with both beams in high spatial quality.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Singh, Sadanand; Pablo, Juan J. de

Recently, novel organic glassy materials that exhibit remarkable stability have been prepared by vapor deposition. The thermophysical properties of these new ''stable'' glasses are equivalent to those that common glasses would exhibit after aging over periods lasting thousands of years. The origin of such enhanced stability has been elusive; in the absence of detailed models, past studies have discussed the formation of new polyamorphs or that of nanocrystals to explain the observed behavior. In this work, an atomistic molecular model of trehalose, a disaccharide of glucose, is used to examine the properties of vapor-deposited stable glasses. Consistent with experiment, themore » model predicts the formation of stable glasses having a higher density, a lower enthalpy, and higher onset temperatures than those of the corresponding ''ordinary'' glass formed by quenching the bulk liquid. Simulations reveal that newly formed layers of the growing vapor-deposited film exhibit greater mobility than the remainder of the material, thereby enabling a reorganization of the film as it is grown. They also reveal that ''stable'' glasses exhibit a distinct layered structure in the direction normal to the substrate that is responsible for their unusual properties.« less

Field Validation of the Stability Limit of a Multi MW Turbine

NASA Astrophysics Data System (ADS)

Kallesøe, Bjarne S.; Kragh, Knud A.

2016-09-01

Long slender blades of modern multi-megawatt turbines exhibit a flutter like instability at rotor speeds above a critical rotor speed. Knowing the critical rotor speed is crucial to a safe turbine design. The flutter like instability can only be estimated using geometrically non-linear aeroelastic codes. In this study, the estimated rotor speed stability limit of a 7 MW state of the art wind turbine is validated experimentally. The stability limit is estimated using Siemens Wind Powers in-house aeroelastic code, and the results show that the predicted stability limit is within 5% of the experimentally observed limit.

Spatial short-term memory in children with nonverbal learning disabilities: impairment in encoding spatial configuration.

PubMed

Narimoto, Tadamasa; Matsuura, Naomi; Takezawa, Tomohiro; Mitsuhashi, Yoshinori; Hiratani, Michio

2013-01-01

The authors investigated whether impaired spatial short-term memory exhibited by children with nonverbal learning disabilities is due to a problem in the encoding process. Children with or without nonverbal learning disabilities performed a simple spatial test that required them to remember 3, 5, or 7 spatial items presented simultaneously in random positions (i.e., spatial configuration) and to decide if a target item was changed or all items including the target were in the same position. The results showed that, even when the spatial positions in the encoding and probe phases were similar, the mean proportion correct of children with nonverbal learning disabilities was 0.58 while that of children without nonverbal learning disabilities was 0.84. The authors argue with the results that children with nonverbal learning disabilities have difficulty encoding relational information between spatial items, and that this difficulty is responsible for their impaired spatial short-term memory.

High-Throughput Ligand Discovery Reveals a Sitewise Gradient of Diversity in Broadly Evolved Hydrophilic Fibronectin Domains

PubMed Central

Woldring, Daniel R.; Holec, Patrick V.; Zhou, Hong; Hackel, Benjamin J.

2015-01-01

Discovering new binding function via a combinatorial library in small protein scaffolds requires balance between appropriate mutations to introduce favorable intermolecular interactions while maintaining intramolecular integrity. Sitewise constraints exist in a non-spatial gradient from diverse to conserved in evolved antibody repertoires; yet non-antibody scaffolds generally do not implement this strategy in combinatorial libraries. Despite the fact that biased amino acid distributions, typically elevated in tyrosine, serine, and glycine, have gained wider use in synthetic scaffolds, these distributions are still predominantly applied uniformly to diversified sites. While select sites in fibronectin domains and DARPins have shown benefit from sitewise designs, they have not been deeply evaluated. Inspired by this disparity between diversity distributions in natural libraries and synthetic scaffold libraries, we hypothesized that binders resulting from discovery and evolution would exhibit a non-spatial, sitewise gradient of amino acid diversity. To identify sitewise diversities consistent with efficient evolution in the context of a hydrophilic fibronectin domain, >105 binders to six targets were evolved and sequenced. Evolutionarily favorable amino acid distributions at 25 sites reveal Shannon entropies (range: 0.3–3.9; median: 2.1; standard deviation: 1.1) supporting the diversity gradient hypothesis. Sitewise constraints in evolved sequences are consistent with complementarity, stability, and consensus biases. Implementation of sitewise constrained diversity enables direct selection of nanomolar affinity binders validating an efficient strategy to balance inter- and intra-molecular interaction demands at each site. PMID:26383268

Patterns of neural activity predict picture-naming performance of a patient with chronic aphasia.

PubMed

Lee, Yune Sang; Zreik, Jihad T; Hamilton, Roy H

2017-01-08

Naming objects represents a substantial challenge for patients with chronic aphasia. This could be in part because the reorganized compensatory language networks of persons with aphasia may be less stable than the intact language systems of healthy individuals. Here, we hypothesized that the degree of stability would be instantiated by spatially differential neural patterns rather than either increased or diminished amplitudes of neural activity within a putative compensatory language system. We recruited a chronic aphasic patient (KL; 66 year-old male) who exhibited a semantic deficit (e.g., often said "milk" for "cow" and "pillow" for "blanket"). Over the course of four behavioral sessions involving a naming task performed in a mock scanner, we identified visual objects that yielded an approximately 50% success rate. We then conducted two fMRI sessions in which the patient performed a naming task for multiple exemplars of those objects. Multivoxel pattern analysis (MVPA) searchlight revealed differential activity patterns associated with correct and incorrect trials throughout intact brain regions. The most robust and largest cluster was found in the right occipito-temporal cortex encompassing fusiform cortex, lateral occipital cortex (LOC), and middle occipital cortex, which may account for the patient's propensity for semantic naming errors. None of these areas were found by a conventional univariate analysis. By using an alternative approach, we extend current evidence for compensatory naming processes that operate through spatially differential patterns within the reorganized language system. Copyright © 2016 Elsevier Ltd. All rights reserved.

Spatial Integration Analysis of Provincial Historical and Cultural Heritage Resources Based on Geographic Information System (gis) — a Case Study of Spatial Integration Analysis of Historical and Cultural Heritage Resources in Zhejiang Province

NASA Astrophysics Data System (ADS)

Luo, W.; Zhang, J.; Wu, Q.; Chen, J.; Huo, X.; Zhang, J.; Zhang, Y.; Wang, T.

2017-08-01

In China historical and cultural heritage resources include historically and culturally famous cities, towns, villages, blocks, immovable cultural relics and the scenic spots with cultural connotation. The spatial distribution laws of these resources are always directly connected to the regional physical geography, historical development and historical traffic geography and have high research values. Meanwhile, the exhibition and use of these resources are greatly influenced by traffic and tourism and other plans at the provincial level, and it is of great realistic significance to offer proposals on traffic and so on that are beneficial to the exhibition of heritage resources based on the research of province distribution laws. This paper takes the spatial analysis of Geographic Information System (GIS) as the basic technological means and all historical and cultural resources in China's Zhejiang Province as research objects, and finds out in the space the accumulation areas and accumulation belts of Zhejiang Province's historic cities and cultural resources through overlay analysis and density analysis, etc. It then discusses the reasons of the formation of these accumulation areas and accumulation belts by combining with the analysis of physical geography and historical geography and so on, and in the end, linking the tourism planning and traffic planning at the provincial level, it provides suggestions on the exhibition and use of accumulation areas and accumulation belts of historic cities and cultural resources.

Predator-prey-subsidy population dynamics on stepping-stone domains with dispersal delays.

PubMed

Eide, Ragna M; Krause, Andrew L; Fadai, Nabil T; Van Gorder, Robert A

2018-08-14

We examine the role of the travel time of a predator along a spatial network on predator-prey population interactions, where the predator is able to partially or fully sustain itself on a resource subsidy. The impact of access to food resources on the stability and behaviour of the predator-prey-subsidy system is investigated, with a primary focus on how incorporating travel time changes the dynamics. The population interactions are modelled by a system of delay differential equations, where travel time is incorporated as discrete delay in the network diffusion term in order to model time taken to migrate between spatial regions. The model is motivated by the Arctic ecosystem, where the Arctic fox consumes both hunted lemming and scavenged seal carcass. The fox travels out on sea ice, in addition to quadrennially migrating over substantial distances. We model the spatial predator-prey-subsidy dynamics through a "stepping-stone" approach. We find that a temporal delay alone does not push species into extinction, but rather may stabilize or destabilize coexistence equilibria. We are able to show that delay can stabilize quasi-periodic or chaotic dynamics, and conclude that the incorporation of dispersal delay has a regularizing effect on dynamics, suggesting that dispersal delay can be proposed as a solution to the paradox of enrichment. Copyright © 2018 Elsevier Ltd. All rights reserved.

Retrosplenial Cortex Indexes Stability beyond the Spatial Domain

PubMed Central

2018-01-01

Retrosplenial cortex (RSC) is highly responsive to landmarks in the environment that remain fixed in a permanent location, and this has been linked with its known involvement in scene and spatial processing. However, it is unclear whether RSC representations of permanence are a purely spatial phenomenon or whether they extend into behavioral and conceptual domains. To test this, during functional MRI scanning, we had people (males and females) read three different types of sentences that described either something permanent or transient. The first two sentence types were imageable, with a focus either on a spatial landmark or on an action. The third type of sentence involved non-imageable abstract concepts. We found that, in addition to being more active for sentences describing landmarks with a permanent location in space, RSC was also significantly engaged by sentences describing stable and consistent behaviors or actions, as long as they were rooted within a concrete imageable setting. RSC was not responsive to abstract concepts, even those that embodied the notion of stability. Similarly, it was not engaged by imageable sentences with transient contents. In contrast, parahippocampal cortex was more engaged by imageable sentences describing landmarks, whereas the hippocampus was active for all imageable sentences. In addition, for imageable sentences describing permanence, there was bidirectional functional coupling between RSC and these medial temporal lobe structures. It appears, therefore, that RSC-mediated permanence representations could be helpful for more than spatially mapping environments and may also provide information about the reliability of events occurring within them. SIGNIFICANCE STATEMENT The retrosplenial cortex (RSC) is known to process information about landmarks in the environment that have a fixed, permanent location. Here we tested whether this permanence response was apparent beyond the spatial domain, which could have implications for understanding the role of the RSC more widely across cognition. We found that the RSC was engaged not only by permanent landmarks but also by stable and consistent actions. It was not responsive to transient landmarks or actions or to abstract concepts, even those that embodied the notion of stability. We conclude that the RSC might do more than help to map spatial environments, by possibly also providing information about the reliability of events occurring within them. PMID:29311139

Temporal Variability and Stability in Infant-Directed Sung Speech: Evidence for Language-Specific Patterns

ERIC Educational Resources Information Center

Falk, Simone

2011-01-01

In this paper, sung speech is used as a methodological tool to explore temporal variability in the timing of word-internal consonants and vowels. It is hypothesized that temporal variability/stability becomes clearer under the varying rhythmical conditions induced by song. This is explored cross-linguistically in German--a language that exhibits a…

Flight-determined aerodynamic derivatives of the AD-1 oblique-wing research airplane

NASA Technical Reports Server (NTRS)

Sim, A. G.; Curry, R. E.

1984-01-01

The AD-1 is a variable-sweep oblique-wing research airplane that exhibits unconventional stability and control characteristics. In this report, flight-determined and predicted stability and control derivatives for the AD-1 airplane are compared. The predictions are based on both wind tunnel and computational results. A final best estimate of derivatives is presented.

Keratin capped silver nanoparticles - synthesis and characterization of a nanomaterial with desirable handling properties

USDA-ARS?s Scientific Manuscript database

Silver nanoparticles (NPs) were produced with keratin stabilizer and the NPs exhibited unimodal Gaussian distribution with average diameter of 3.5nm +/- 0.7 nm. The molecular mass of keratin stabilizer was 6-8 kDa. The mass of keratin capped NPs was >250 kDa to indicate the formation of crosslinked...

Entropy Stable Spectral Collocation Schemes for the Navier-Stokes Equations: Discontinuous Interfaces

NASA Technical Reports Server (NTRS)

Carpenter, Mark H.; Fisher, Travis C.; Nielsen, Eric J.; Frankel, Steven H.

2013-01-01

Nonlinear entropy stability and a summation-by-parts framework are used to derive provably stable, polynomial-based spectral collocation methods of arbitrary order. The new methods are closely related to discontinuous Galerkin spectral collocation methods commonly known as DGFEM, but exhibit a more general entropy stability property. Although the new schemes are applicable to a broad class of linear and nonlinear conservation laws, emphasis herein is placed on the entropy stability of the compressible Navier-Stokes equations.

Formalized description and construction of semantic dictionary of graphic-text spatial relationship

NASA Astrophysics Data System (ADS)

Sun, Yizhong; Xue, Xiaolei; Zhao, Xiaoqin

2008-10-01

Graphic and text are two major elements in exhibiting of the results of urban planning and land administration. In combination, they convey the complex relationship resulting from spatial analysis and decision-making. Accurately interpreting and representing these relationships are important steps towards an intelligent GIS for urban planning. This paper employs concept-hierarchy-tree to formalize graphic-text relationships through a framework of spatial object lexicon, spatial relationship lexicon, restriction lexicon, applied pattern base, and word segmentation rule base. The methodology is further verified and shown effective on several urban planning archives.

Development of model-based control for Bridgman crystal growth

NASA Astrophysics Data System (ADS)

Sonda, Paul; Yeckel, Andrew; Daoutidis, Prodromos; Derby, Jeffrey. J.

2004-05-01

We study the feasibility of using crucible rotation with feedback control to suppress oscillatory flows in two prototypical vertical Bridgman crystal growth systems—a stabilizing configuration driven by a time-oscillatory furnace disturbance and a thermally destabilized configuration, which exhibits inherent time-varying flows. Proportional controllers are applied to the two systems, with volume-averaged flow speed chosen as the single controlled output and crucible rotation chosen as the manipulated input. Proportional control is able to significantly suppress oscillations in the stabilizing configuration. For the destabilized case, control is effective for small-amplitude flows but is generally ineffective, due to the exacerbating effect of crucible rotation on the time-dependent flows exhibited by this system.

Preparation and Characterization of InP/Poly(methyl methacrylate) Nanocomposite Films.

PubMed

Kwon, Younghoon; Kim, Jongsung

2017-04-01

Quantum dots (QDs) are nanocrystalline semiconductors with many unusual optical properties. They exhibit very high fluorescence intensities and possess exceptional stability against photo-bleaching. In this study, we report the preparation of InP QDs-poly(methyl methacrylate) (PMMA) hybrids by fabricating QDs via a thermal decomposition reaction, followed by radical polymerization. The InP QDs were synthesized using indium(III) chloride and tris(dimethylamino)phosphine. Flexible composite films were obtained by radical polymerization using methyl methacrylate (MMA) as the monomer and 2,2′-azobis(2-methylpropionitrile) (AIBN) as a radical initiator. The PL intensity of the QDs was lowered upon composite formation with PMMA. However, the composites exhibited higher thermal stability than pure PMMA.

Hailstorm forecast from stability indexes in Southwestern France

NASA Astrophysics Data System (ADS)

Melcón, Pablo; Merino, Andrés; Sánchez, José Luis; Dessens, Jean; Gascón, Estíbaliz; Berthet, Claude; López, Laura; García-Ortega, Eduardo

2016-04-01

Forecasting hailstorms is a difficult task because of their small spatial and temporal scales. Over recent decades, stability indexes have been commonly used in operational forecasting to provide a simplified representation of different thermodynamic characteristics of the atmosphere, regarding the onset of convective events. However, they are estimated from vertical profiles obtained by radiosondes, which are usually available only twice a day and have limited spatial representativeness. Numerical models predictions can be used to overcome these drawbacks, providing vertical profiles with higher spatiotemporal resolution. The main objective of this study is to create a tool for hail prediction in the southwest of France, one of the European regions where hailstorms have a higher incidence. The Association Nationale d'Etude et de Lutte contre les Fleáux Atmosphériques (ANELFA) maintains there a dense hailpad network in continuous operation, which has created an extensive database of hail events, used in this study as ground truth. The new technique is aimed to classify the spatial distribution of different stability indexes on hail days. These indexes were calculated from vertical profiles at 1200 UTC provided by WRF numerical model, validated with radiosonde data from Bordeaux. Binary logistic regression is used to select those indexes that best represent thermodynamic conditions related to occurrence of hail in the zone. Then, they are combined in a single algorithm that surpassed the predictive power they have when used independently. Regression equation results in hail days are used in cluster analysis to identify different spatial patterns given by the probability algorithm. This new tool can be used in operational forecasting, in combination with synoptic and mesoscale techniques, to properly define hail probability and distribution. Acknowledgements The authors would like to thank the CEPA González Díez Foundation and the University of Leon for its financial support.

Throughfall and its spatial variability beneath xerophytic shrub canopies within water-limited arid desert ecosystems

NASA Astrophysics Data System (ADS)

Zhang, Ya-feng; Wang, Xin-ping; Hu, Rui; Pan, Yan-xia

2016-08-01

Throughfall is known to be a critical component of the hydrological and biogeochemical cycles of forested ecosystems with inherently temporal and spatial variability. Yet little is understood concerning the throughfall variability of shrubs and the associated controlling factors in arid desert ecosystems. Here we systematically investigated the variability of throughfall of two morphological distinct xerophytic shrubs (Caragana korshinskii and Artemisia ordosica) within a re-vegetated arid desert ecosystem, and evaluated the effects of shrub structure and rainfall characteristics on throughfall based on heavily gauged throughfall measurements at the event scale. We found that morphological differences were not sufficient to generate significant difference (P < 0.05) in throughfall between two studied shrub species under the same rainfall and meteorological conditions in our study area, with a throughfall percentage of 69.7% for C. korshinskii and 64.3% for A. ordosica. We also observed a highly variable patchy pattern of throughfall beneath individual shrub canopies, but the spatial patterns appeared to be stable among rainfall events based on time stability analysis. Throughfall linearly increased with the increasing distance from the shrub base for both shrubs, and radial direction beneath shrub canopies had a pronounced impact on throughfall. Throughfall variability, expressed as the coefficient of variation (CV) of throughfall, tended to decline with the increase in rainfall amount, intensity and duration, and stabilized passing a certain threshold. Our findings highlight the great variability of throughfall beneath the canopies of xerophytic shrubs and the time stability of throughfall pattern among rainfall events. The spatially heterogeneous and temporally stable throughfall is expected to generate a dynamic patchy distribution of soil moisture beneath shrub canopies within arid desert ecosystems.

Solitons and vortices in two-dimensional discrete nonlinear Schrödinger systems with spatially modulated nonlinearity

DOE PAGES

Kevrekidis, P. G.; Malomed, Boris A.; Saxena, Avadh; ...

2015-04-07

We consider a two-dimensional (2D) generalization of a recently proposed model [Phys. Rev. E 88, 032905 (2013)], which gives rise to bright discrete solitons supported by the defocusing nonlinearity whose local strength grows from the center to the periphery. We explore the 2D model starting from the anticontinuum (AC) limit of vanishing coupling. In this limit, we can construct a wide variety of solutions including not only single-site excitations, but also dipole and quadrupole ones. Additionally, two separate families of solutions are explored: the usual “extended” unstaggered bright solitons, in which all sites are excited in the AC limit, withmore » the same sign across the lattice (they represent the most robust states supported by the lattice, their 1D counterparts being those considered as 1D bright solitons in the above-mentioned work), and the vortex cross, which is specific to the 2D setting. For all the existing states, we explore their stability (also analytically, when possible). As a result, typical scenarios of instability development are exhibited through direct simulations.« less

An in situ USAXS-SAXS-WAXS study of precipitate size distribution evolution in a model Ni-based alloy.

PubMed

Andrews, Ross N; Serio, Joseph; Muralidharan, Govindarajan; Ilavsky, Jan

2017-06-01

Intermetallic γ' precipitates typically strengthen nickel-based superalloys. The shape, size and spatial distribution of strengthening precipitates critically influence alloy strength, while their temporal evolution characteristics determine the high-temperature alloy stability. Combined ultra-small-, small- and wide-angle X-ray scattering (USAXS-SAXS-WAXS) analysis can be used to evaluate the temporal evolution of an alloy's precipitate size distribution (PSD) and phase structure during in situ heat treatment. Analysis of PSDs from USAXS-SAXS data employs either least-squares fitting of a preordained PSD model or a maximum entropy (MaxEnt) approach, the latter avoiding a priori definition of a functional form of the PSD. However, strong low- q scattering from grain boundaries and/or structure factor effects inhibit MaxEnt analysis of typical alloys. This work describes the extension of Bayesian-MaxEnt analysis methods to data exhibiting structure factor effects and low- q power law slopes and demonstrates their use in an in situ study of precipitate size evolution during heat treatment of a model Ni-Al-Si alloy.

An in situ USAXS–SAXS–WAXS study of precipitate size distribution evolution in a model Ni-based alloy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Andrews, Ross N.; Serio, Joseph A.; Muralidharan, Govindarajan

Intermetallic γ' precipitates typically strengthen nickel-based superalloys. The shape, size and spatial distribution of strengthening precipitates critically influence alloy strength, while their temporal evolution characteristics determine the high-temperature alloy stability. Combined ultra-small-, small- and wide-angle X-ray scattering (USAXS–SAXS–WAXS) analysis can be used to evaluate the temporal evolution of an alloy's precipitate size distribution (PSD) and phase structure duringin situheat treatment. Analysis of PSDs from USAXS–SAXS data employs either least-squares fitting of a preordained PSD model or a maximum entropy (MaxEnt) approach, the latter avoidinga prioridefinition of a functional form of the PSD. However, strong low-qscattering from grain boundaries and/or structuremore » factor effects inhibit MaxEnt analysis of typical alloys. Lastly, this work describes the extension of Bayesian–MaxEnt analysis methods to data exhibiting structure factor effects and low-qpower law slopes and demonstrates their use in anin situstudy of precipitate size evolution during heat treatment of a model Ni–Al–Si alloy.« less

Potential use of fatty acid profiles of the adductor muscle of cockles (Cerastoderma edule) for traceability of collection site

PubMed Central

Ricardo, Fernando; Pimentel, Tânia; Moreira, Ana S. P.; Rey, Felisa; Coimbra, Manuel A.; Rosário Domingues, M.; Domingues, Pedro; Costa Leal, Miguel; Calado, Ricardo

2015-01-01

Geographic traceability of seafood is key for controlling its quality and safeguarding consumers’ interest. The present study assessed if the fatty acid (FA) profile of the adductor muscle (AM) of fresh cockles (Cerastoderma edule) can be used to discriminate the origin of specimens collected in different bivalve capture/production areas legally defined within a coastal lagoon. Results suggest that this biochemical approach holds the potential to trace sampling locations with a spatial resolution <10 Km, even for areas with identical classification for bivalve production. Cockles further away from the inlet, i.e. in areas exposed to a higher saline variation, exhibited lower levels of saturated fatty acids, which are key for stabilizing the bilayer structure of cell membranes, and a higher percentage of polyunsaturated fatty acids, which enhance bilayer fluidity. Results suggest that the structural nature of the lipids present in the AM provides a stable fatty acid signature and holds potential for tracing the origin of bivalves to their capture/production areas. PMID:26084395

Entropy Stable Staggered Grid Spectral Collocation for the Burgers' and Compressible Navier-Stokes Equations

NASA Technical Reports Server (NTRS)

Carpenter, Mark H.; Parsani, Matteo; Fisher, Travis C.; Nielsen, Eric J.

2015-01-01

Staggered grid, entropy stable discontinuous spectral collocation operators of any order are developed for Burgers' and the compressible Navier-Stokes equations on unstructured hexahedral elements. This generalization of previous entropy stable spectral collocation work [1, 2], extends the applicable set of points from tensor product, Legendre-Gauss-Lobatto (LGL) to a combination of tensor product Legendre-Gauss (LG) and LGL points. The new semi-discrete operators discretely conserve mass, momentum, energy and satisfy a mathematical entropy inequality for both Burgers' and the compressible Navier-Stokes equations in three spatial dimensions. They are valid for smooth as well as discontinuous flows. The staggered LG and conventional LGL point formulations are compared on several challenging test problems. The staggered LG operators are significantly more accurate, although more costly to implement. The LG and LGL operators exhibit similar robustness, as is demonstrated using test problems known to be problematic for operators that lack a nonlinearly stability proof for the compressible Navier-Stokes equations (e.g., discontinuous Galerkin, spectral difference, or flux reconstruction operators).

Analysis of Rotation and Transport Data in C-Mod ITB Plasmas

NASA Astrophysics Data System (ADS)

Fiore, C. L.; Rice, J. E.; Reinke, M. L.; Podpaly, Y.; Bespamyatnov, I. O.; Rowan, W. L.

2009-11-01

Internal transport barriers (ITBs) spontaneously form near the half radius of Alcator C-Mod plasmas when the EDA H-mode is sustained for several energy confinement times in either off-axis ICRF heated discharges or in purely ohmic heated plasmas. These plasmas exhibit strongly peaked density and pressure profiles, static or peaking temperature profiles, peaking impurity density profiles, and thermal transport coefficients that approach neoclassical values in the core. It has long been observed that the intrinsic central plasma rotation that is strongly co-current following the H-mode transition slows and often reverses as the density peaks as the ITB forms. Recent spatial measurements demonstrate that the rotation profile develops a well in the core region that decreases continuously as central density rises while the value outside of the core remains strongly co-current. This results in the formation of a steep potential gradient/strong electric field at the location of the foot of the ITB density profile. The resulting E X B shearing rate is also quite significant at the foot. These analyses and the implications for plasma transport and stability will be presented.

An in situ USAXS–SAXS–WAXS study of precipitate size distribution evolution in a model Ni-based alloy1

PubMed Central

Andrews, Ross N.; Serio, Joseph; Muralidharan, Govindarajan; Ilavsky, Jan

2017-01-01

Intermetallic γ′ precipitates typically strengthen nickel-based superalloys. The shape, size and spatial distribution of strengthening precipitates critically influence alloy strength, while their temporal evolution characteristics determine the high-temperature alloy stability. Combined ultra-small-, small- and wide-angle X-ray scattering (USAXS–SAXS–WAXS) analysis can be used to evaluate the temporal evolution of an alloy’s precipitate size distribution (PSD) and phase structure during in situ heat treatment. Analysis of PSDs from USAXS–SAXS data employs either least-squares fitting of a preordained PSD model or a maximum entropy (MaxEnt) approach, the latter avoiding a priori definition of a functional form of the PSD. However, strong low-q scattering from grain boundaries and/or structure factor effects inhibit MaxEnt analysis of typical alloys. This work describes the extension of Bayesian–MaxEnt analysis methods to data exhibiting structure factor effects and low-q power law slopes and demonstrates their use in an in situ study of precipitate size evolution during heat treatment of a model Ni–Al–Si alloy. PMID:28656039

Contrasting evolutionary patterns in two reef-corals and their possible relationship to life history traits

DOE Office of Scientific and Technical Information (OSTI.GOV)

Foster, A.B.

1985-01-01

Multivariate statistical analyses have been used to redefine species within two genera of reef-corals (Porites and Montastraea) and to trace their evolutionary patterns through a continuous sequence from late Miocene to early Pliocene time. The material studied consists of populations sampled at regular intervals through four stratigraphic sections in the northern Dominican Republic. The results show that species in the first genus (Porites) have relatively short durations, morphologic stability, and narrow spatial distributions. Their overall evolutionary history is characterized by short periods of radiation and widespread extinction, separated by longer periods of stasis. In contrast, species in the second genusmore » (Montastraea) exhibit various different durations and distributions and directional morphologic trends. These differences in patterns may be related to the dissimilar life histories of the two genera. Patterns in the first genus appear more common in organisms having high larval recruitment, high mortality, high genetic variation, and less morphologic distance between species. Patterns in the second genus occur more frequently in slower growing, phenotypically plastic organisms experiencing less recruitment and mortality and showing more morphologic distance between species.« less

Assessment of swirl spray interaction in lab scale combustor using time-resolved measurements

NASA Astrophysics Data System (ADS)

Rajamanickam, Kuppuraj; Jain, Manish; Basu, Saptarshi

2017-11-01

Liquid fuel injection in highly turbulent swirling flows becomes common practice in gas turbine combustors to improve the flame stabilization. It is well known that the vortex bubble breakdown (VBB) phenomenon in strong swirling jets exhibits complicated flow structures in the spatial domain. In this study, the interaction of hollow cone liquid sheet with such coaxial swirling flow field has been studied experimentally using time-resolved measurements. In particular, much attention is focused towards the near field breakup mechanism (i.e. primary atomization) of liquid sheet. The detailed swirling gas flow field characterization is carried out using time-resolved PIV ( 3.5 kHz). Furthermore, the complicated breakup mechanisms and interaction of the liquid sheet are imaged with the help of high-speed shadow imaging system. Subsequently, proper orthogonal decomposition (POD) and dynamic mode decomposition (DMD) is implemented over the instantaneous data sets to retrieve the modal information associated with the interaction dynamics. This helps to delineate more quantitative nature of interaction process between the liquid sheet and swirling gas phase flow field.

Ultraflexible, large-area, physiological temperature sensors for multipoint measurements

PubMed Central

Yokota, Tomoyuki; Inoue, Yusuke; Terakawa, Yuki; Reeder, Jonathan; Kaltenbrunner, Martin; Ware, Taylor; Yang, Kejia; Mabuchi, Kunihiko; Murakawa, Tomohiro; Sekino, Masaki; Voit, Walter; Sekitani, Tsuyoshi; Someya, Takao

2015-01-01

We report a fabrication method for flexible and printable thermal sensors based on composites of semicrystalline acrylate polymers and graphite with a high sensitivity of 20 mK and a high-speed response time of less than 100 ms. These devices exhibit large resistance changes near body temperature under physiological conditions with high repeatability (1,800 times). Device performance is largely unaffected by bending to radii below 700 µm, which allows for conformal application to the surface of living tissue. The sensing temperature can be tuned between 25 °C and 50 °C, which covers all relevant physiological temperatures. Furthermore, we demonstrate flexible active-matrix thermal sensors which can resolve spatial temperature gradients over a large area. With this flexible ultrasensitive temperature sensor we succeeded in the in vivo measurement of cyclic temperatures changes of 0.1 °C in a rat lung during breathing, without interference from constant tissue motion. This result conclusively shows that the lung of a warm-blooded animal maintains surprising temperature stability despite the large difference between core temperature and inhaled air temperature. PMID:26554008

Instability of turing patterns in reaction-diffusion-ODE systems.

PubMed

Marciniak-Czochra, Anna; Karch, Grzegorz; Suzuki, Kanako

2017-02-01

The aim of this paper is to contribute to the understanding of the pattern formation phenomenon in reaction-diffusion equations coupled with ordinary differential equations. Such systems of equations arise, for example, from modeling of interactions between cellular processes such as cell growth, differentiation or transformation and diffusing signaling factors. We focus on stability analysis of solutions of a prototype model consisting of a single reaction-diffusion equation coupled to an ordinary differential equation. We show that such systems are very different from classical reaction-diffusion models. They exhibit diffusion-driven instability (turing instability) under a condition of autocatalysis of non-diffusing component. However, the same mechanism which destabilizes constant solutions of such models, destabilizes also all continuous spatially heterogeneous stationary solutions, and consequently, there exist no stable Turing patterns in such reaction-diffusion-ODE systems. We provide a rigorous result on the nonlinear instability, which involves the analysis of a continuous spectrum of a linear operator induced by the lack of diffusion in the destabilizing equation. These results are extended to discontinuous patterns for a class of nonlinearities.

First-principles study of the solid solution of hydrogen in lanthanum

DOE Office of Scientific and Technical Information (OSTI.GOV)

Schoellhammer, Gunther; Herzig, Peter; Wolf, Walter

2011-09-01

Results from first-principles investigations of the energetical, structural, electronic, and vibrational properties of model structures probing the metal-rich region of the lanthanum-hydrogen system, i.e., the region of the solid solution of hydrogen in lanthanum, are presented. We have studied the site preference and the ordering tendency of hydrogen atoms interstitially bonded in close-packed lanthanum. Spatially separated hydrogen atoms have turned out to exhibit an energetical preference for the occupation of octahedral interstitial sites at low temperature. Indications for a reversal of the site preference in favor of the occupation of tetrahedral interstitial sites at elevated temperature have been found. Linearmore » arrangements consisting of pairs of octahedrally and/or tetrahedrally coordinated hydrogen atoms collinearly bonded to a central lanthanum atom have turned out to be energetically favorable structure elements. Further stabilization is achieved if such hydrogen pairs are in turn linked together so that extended chains of La-H bonds are formed. Pair formation and chain linking counteract the energetical preference for octahedral coordination observed for separated hydrogen atoms.« less

An in situ USAXS–SAXS–WAXS study of precipitate size distribution evolution in a model Ni-based alloy

DOE PAGES

Andrews, Ross N.; Serio, Joseph A.; Muralidharan, Govindarajan; ...

2017-05-30

Intermetallic γ' precipitates typically strengthen nickel-based superalloys. The shape, size and spatial distribution of strengthening precipitates critically influence alloy strength, while their temporal evolution characteristics determine the high-temperature alloy stability. Combined ultra-small-, small- and wide-angle X-ray scattering (USAXS–SAXS–WAXS) analysis can be used to evaluate the temporal evolution of an alloy's precipitate size distribution (PSD) and phase structure duringin situheat treatment. Analysis of PSDs from USAXS–SAXS data employs either least-squares fitting of a preordained PSD model or a maximum entropy (MaxEnt) approach, the latter avoidinga prioridefinition of a functional form of the PSD. However, strong low-qscattering from grain boundaries and/or structuremore » factor effects inhibit MaxEnt analysis of typical alloys. Lastly, this work describes the extension of Bayesian–MaxEnt analysis methods to data exhibiting structure factor effects and low-qpower law slopes and demonstrates their use in anin situstudy of precipitate size evolution during heat treatment of a model Ni–Al–Si alloy.« less

Capacitive Pressure Sensor with High Sensitivity and Fast Response to Dynamic Interaction Based on Graphene and Porous Nylon Networks.

PubMed

He, Zhongfu; Chen, Wenjun; Liang, Binghao; Liu, Changyong; Yang, Leilei; Lu, Dongwei; Mo, Zichao; Zhu, Hai; Tang, Zikang; Gui, Xuchun

2018-04-18

Flexible pressure sensors are of great importance to be applied in artificial intelligence and wearable electronics. However, assembling a simple structure, high-performance capacitive pressure sensor, especially for monitoring the flow of liquids, is still a big challenge. Here, on the basis of a sandwich-like structure, we propose a facile capacitive pressure sensor optimized by a flexible, low-cost nylon netting, showing many merits including a high response sensitivity (0.33 kPa -1 ) in a low-pressure regime (<1 kPa), an ultralow detection limit as 3.3 Pa, excellent working stability after more than 1000 cycles, and synchronous monitoring for human pulses and clicks. More important, this sensor exhibits an ultrafast response speed (<20 ms), which enables its detection for the fast variations of a small applied pressure from the morphological changing processes of a droplet falling onto the sensor. Furthermore, a capacitive pressure sensor array is fabricated for demonstrating the ability to spatial pressure distribution. Our developed pressure sensors show great prospects in practical applications such as health monitoring, flexible tactile devices, and motion detection.

Ultraflexible, large-area, physiological temperature sensors for multipoint measurements.

PubMed

Yokota, Tomoyuki; Inoue, Yusuke; Terakawa, Yuki; Reeder, Jonathan; Kaltenbrunner, Martin; Ware, Taylor; Yang, Kejia; Mabuchi, Kunihiko; Murakawa, Tomohiro; Sekino, Masaki; Voit, Walter; Sekitani, Tsuyoshi; Someya, Takao

2015-11-24

We report a fabrication method for flexible and printable thermal sensors based on composites of semicrystalline acrylate polymers and graphite with a high sensitivity of 20 mK and a high-speed response time of less than 100 ms. These devices exhibit large resistance changes near body temperature under physiological conditions with high repeatability (1,800 times). Device performance is largely unaffected by bending to radii below 700 µm, which allows for conformal application to the surface of living tissue. The sensing temperature can be tuned between 25 °C and 50 °C, which covers all relevant physiological temperatures. Furthermore, we demonstrate flexible active-matrix thermal sensors which can resolve spatial temperature gradients over a large area. With this flexible ultrasensitive temperature sensor we succeeded in the in vivo measurement of cyclic temperatures changes of 0.1 °C in a rat lung during breathing, without interference from constant tissue motion. This result conclusively shows that the lung of a warm-blooded animal maintains surprising temperature stability despite the large difference between core temperature and inhaled air temperature.

Phase synchrony reveals organization in human atrial fibrillation

PubMed Central

Vidmar, David; Narayan, Sanjiv M.

2015-01-01

It remains unclear if human atrial fibrillation (AF) is spatially nonhierarchical or exhibits a hierarchy of organization sustained by sources. We utilize activation times obtained at discrete locations during AF to compute the phase synchrony between tissue regions, to examine underlying spatial dynamics throughout both atria. We construct a binary synchronization network and show that this network can accurately define regions of coherence in coarse-grained in silico data. Specifically, domains controlled by spiral waves exhibit regions of high phase synchrony. We then apply this analysis to clinical data from patients experiencing cardiac arrhythmias using multielectrode catheters to simultaneously record from a majority of both atria. We show that pharmaceutical intervention with ibutilide organizes activation by increasing the size of the synchronized domain in AF and quantify the increase in temporal organization when arrhythmia changes from fibrillation to tachycardia. Finally, in recordings from 24 patients in AF we show that the level of synchrony is spatially broad with some patients showing large spatially contiguous regions of synchronization, while in others synchrony is localized to small pockets. Using computer simulations, we show that this distribution is inconsistent with distributions obtained from simulations that mimic multiwavelet reentry but is consistent with mechanisms in which one or more spatially conserved spiral waves is surrounded by tissue in which activation is disorganized. PMID:26475585

Analysis of temporal decay of diffuse broadband sound fields in enclosures by decomposition in powers of an absorption parameter

NASA Astrophysics Data System (ADS)

Bliss, Donald; Franzoni, Linda; Rouse, Jerry; Manning, Ben

2005-09-01

An analysis method for time-dependent broadband diffuse sound fields in enclosures is described. Beginning with a formulation utilizing time-dependent broadband intensity boundary sources, the strength of these wall sources is expanded in a series in powers of an absorption parameter, thereby giving a separate boundary integral problem for each power. The temporal behavior is characterized by a Taylor expansion in the delay time for a source to influence an evaluation point. The lowest-order problem has a uniform interior field proportional to the reciprocal of the absorption parameter, as expected, and exhibits relatively slow exponential decay. The next-order problem gives a mean-square pressure distribution that is independent of the absorption parameter and is primarily responsible for the spatial variation of the reverberant field. This problem, which is driven by input sources and the lowest-order reverberant field, depends on source location and the spatial distribution of absorption. Additional problems proceed at integer powers of the absorption parameter, but are essentially higher-order corrections to the spatial variation. Temporal behavior is expressed in terms of an eigenvalue problem, with boundary source strength distributions expressed as eigenmodes. Solutions exhibit rapid short-time spatial redistribution followed by long-time decay of a predominant spatial mode.

Spatial synchrony in cisco recruitment

USGS Publications Warehouse

Myers, Jared T.; Yule, Daniel L.; Jones, Michael L.; Ahrenstorff, Tyler D.; Hrabik, Thomas R.; Claramunt, Randall M.; Ebener, Mark P.; Berglund, Eric K.

2015-01-01

We examined the spatial scale of recruitment variability for disparate cisco (Coregonus artedi) populations in the Great Lakes (n = 8) and Minnesota inland lakes (n = 4). We found that the scale of synchrony was approximately 400 km when all available data were utilized; much greater than the 50-km scale suggested for freshwater fish populations in an earlier global analysis. The presence of recruitment synchrony between Great Lakes and inland lake cisco populations supports the hypothesis that synchronicity is driven by climate and not dispersal. We also found synchrony in larval densities among three Lake Superior populations separated by 25–275 km, which further supports the hypothesis that broad-scale climatic factors are the cause of spatial synchrony. Among several candidate climate variables measured during the period of larval cisco emergence, maximum wind speeds exhibited the most similar spatial scale of synchrony to that observed for cisco. Other factors, such as average water temperatures, exhibited synchrony on broader spatial scales, which suggests they could also be contributing to recruitment synchrony. Our results provide evidence that abiotic factors can induce synchronous patterns of recruitment for populations of cisco inhabiting waters across a broad geographic range, and show that broad-scale synchrony of recruitment can occur in freshwater fish populations as well as those from marine systems.

Coherence properties of the radiation from FLASH

NASA Astrophysics Data System (ADS)

Schneidmiller, E. A.; Yurkov, M. V.

2016-02-01

Free electron LASer in Hamburg is the first free electron laser user facility operating in the vacuum ultraviolet and soft X-ray wavelength range. Many user experiments require knowledge of the spatial and temporal coherence properties of the radiation. In this paper, we present a theoretical analysis of the coherence properties of the radiation for the fundamental and for the higher odd frequency harmonics. We show that temporal and spatial coherence reach their maxima close to the free electron laser (FEL) saturation but may degrade significantly in the post-saturation regime. We also find that the pointing stability of short FEL pulses is limited due to the fact that nonazimuthal FEL eigenmodes are not sufficiently suppressed. We discuss possible ways for improving the degree of transverse coherence and the pointing stability.

Spatial Distribution of Bed Particles in Natural Boulder-Bed Streams

NASA Astrophysics Data System (ADS)

Clancy, K. F.; Prestegaard, K. L.

2001-12-01

The Wolman pebble count is used to obtain the size distribution of bed particles in natural streams. Statistics such as median particle size (D50) are used in resistance calculations. Additional information such as bed particle heterogeneity may also be obtained from the particle distribution, which is used to predict sediment transport rates (Hey, 1979), (Ferguson, Prestegaard, Ashworth, 1989). Boulder-bed streams have an extreme range of particles in the particle size distribution ranging from sand size particles to particles larger than 0.5-m. A study of a natural boulder-bed reach demonstrated that the spatial distribution of the particles is a significant factor in predicting sediment transport and stream bed and bank stability. Further experiments were performed to test the limits of the spatial distribution's effect on sediment transport. Three stream reaches 40-m in length were selected with similar hydrologic characteristics and spatial distributions but varying average size particles. We used a grid 0.5 by 0.5-m and measured four particles within each grid cell. Digital photographs of the streambed were taken in each grid cell. The photographs were examined using image analysis software to obtain particle size and position of the largest particles (D84) within the reach's particle distribution. Cross section, topography and stream depth were surveyed. Velocity and velocity profiles were measured and recorded. With these data and additional surveys of bankfull floods, we tested the significance of the spatial distributions as average particle size decreases. The spatial distribution of streambed particles may provide information about stream valley formation, bank stability, sediment transport, and the growth rate of riparian vegetation.

Stabilized Acoustic Levitation of Dense Materials Using a High-Powered Siren

NASA Technical Reports Server (NTRS)

Gammell, P. M.; Croonquist, A.; Wang, T. G.

1982-01-01

Stabilized acoustic levitation and manipulation of dense (e.g., steel) objects of 1 cm diameter, using a high powered siren, was demonstrated in trials that investigated the harmonic content and spatial distribution of the acoustic field, as well as the effect of sample position and reflector geometries on the acoustic field. Although further optimization is possible, the most stable operation achieved is expected to be adequate for most containerless processing applications. Best stability was obtained with an open reflector system, using a flat lower reflector and a slightly concave upper one. Operation slightly below resonance enhances stability as this minimizes the second harmonic, which is suspected of being a particularly destabilizing influence.

Surface Nanobubbles Are Stabilized by Hydrophobic Attraction.

PubMed

Tan, Beng Hau; An, Hongjie; Ohl, Claus-Dieter

2018-04-20

The remarkably long lifetime of surface nanobubbles has perplexed researchers for two decades. The current understanding is that both contact line pinning and supersaturation of the ambient liquid are strictly required for the stability of nanobubbles, yet experiments show nanobubbles surviving in open systems and undersaturated environments. We find that this discrepancy can be addressed if the effects of an attractive hydrophobic potential at the solid substrate on the spatial distribution of the gas concentration is taken into account. We also show that, in our model, only substrate pinning is strictly required for stabilization; while hydrophobicity and supersaturation both aid stability, neither is mandatory-the absence of one can be compensated by an excess of the other.

Surface Nanobubbles Are Stabilized by Hydrophobic Attraction

NASA Astrophysics Data System (ADS)

Tan, Beng Hau; An, Hongjie; Ohl, Claus-Dieter

2018-04-01

The remarkably long lifetime of surface nanobubbles has perplexed researchers for two decades. The current understanding is that both contact line pinning and supersaturation of the ambient liquid are strictly required for the stability of nanobubbles, yet experiments show nanobubbles surviving in open systems and undersaturated environments. We find that this discrepancy can be addressed if the effects of an attractive hydrophobic potential at the solid substrate on the spatial distribution of the gas concentration is taken into account. We also show that, in our model, only substrate pinning is strictly required for stabilization; while hydrophobicity and supersaturation both aid stability, neither is mandatory—the absence of one can be compensated by an excess of the other.

Is the Recall of Verbal-Spatial Information from Working Memory Affected by Symptoms of ADHD?

ERIC Educational Resources Information Center

Caterino, Linda C.; Verdi, Michael P.

2012-01-01

Objective: The Kulhavy model for text learning using organized spatial displays proposes that learning will be increased when participants view visual images prior to related text. In contrast to previous studies, this study also included students who exhibited symptoms of ADHD. Method: Participants were presented with either a map-text or…

Factors influencing spatial variability in nitrogen processing in nitrogen-saturated soils

Treesearch

Frank S. Gilliam; Charles C. Somerville; Nikki L. Lyttle; Mary Beth Adams

2001-01-01

Nitrogen (N) saturation is an environmental concern for forests in the eastern U.S. Although several watersheds of the Fernow Experimental Forest (FEF), West Virginia exhibit symptoms of N saturation, many watersheds display a high degree of spatial variability in soil N processing. This study examined the effects of temperature on net N mineralization and...

[GLIATILIN CORRECTION OF WORKING AND REFERENCE SPATIAL MEMORY IMPAIRMENT IN AGED RATS].

PubMed

Tyurenkov, I N; Volotova, E V; Kurkin, D V

2015-01-01

This work was aimed at evaluating the influence of gliatilin administration on the spatial memory in aged rats. Cognitive function and spatial memory in animals was evaluated using radial (8-beam) maze test. Errors of working spatial memory and reference memory were used as indicators of impaired cognitive function. It was found that aged (24-month) rats compared with younger (6-months) age group exhibited cognitive impairment, as manifested by deterioration of short- and long-term memory processes. Course administration of gliatilin in rats of the older age group at a dose of 100 mg/kg resulted in significant improvement of the working and reference spatial memory in aged rats.

The effect of short-range spatial variability on soil sampling uncertainty.

PubMed

Van der Perk, Marcel; de Zorzi, Paolo; Barbizzi, Sabrina; Belli, Maria; Fajgelj, Ales; Sansone, Umberto; Jeran, Zvonka; Jaćimović, Radojko

2008-11-01

This paper aims to quantify the soil sampling uncertainty arising from the short-range spatial variability of elemental concentrations in the topsoils of agricultural, semi-natural, and contaminated environments. For the agricultural site, the relative standard sampling uncertainty ranges between 1% and 5.5%. For the semi-natural area, the sampling uncertainties are 2-4 times larger than in the agricultural area. The contaminated site exhibited significant short-range spatial variability in elemental composition, which resulted in sampling uncertainties of 20-30%.

Bimodal spatial distribution of macular pigment: evidence of a gender relationship

NASA Astrophysics Data System (ADS)

Delori, François C.; Goger, Douglas G.; Keilhauer, Claudia; Salvetti, Paola; Staurenghi, Giovanni

2006-03-01

The spatial distribution of the optical density of the human macular pigment measured by two-wavelength autofluorescence imaging exhibits in over half of the subjects an annulus of higher density superimposed on a central exponential-like distribution. This annulus is located at about 0.7° from the fovea. Women have broader distributions than men, and they are more likely to exhibit this bimodal distribution. Maxwell's spot reported by subjects matches the measured distribution of their pigment. Evidence that the shape of the foveal depression may be gender related leads us to hypothesize that differences in macular pigment distribution are related to anatomical differences in the shape of the foveal depression.

Concurrent Increases and Decreases in Local Stability and Conformational Heterogeneity in Cu, Zn Superoxide Dismutase Variants Revealed by Temperature-Dependence of Amide Chemical Shifts.

PubMed

Doyle, Colleen M; Rumfeldt, Jessica A; Broom, Helen R; Sekhar, Ashok; Kay, Lewis E; Meiering, Elizabeth M

2016-03-08

The chemical shifts of backbone amide protons in proteins are sensitive reporters of local structural stability and conformational heterogeneity, which can be determined from their readily measured linear and nonlinear temperature-dependences, respectively. Here we report analyses of amide proton temperature-dependences for native dimeric Cu, Zn superoxide dismutase (holo pWT SOD1) and structurally diverse mutant SOD1s associated with amyotrophic lateral sclerosis (ALS). Holo pWT SOD1 loses structure with temperature first at its periphery and, while having extremely high global stability, nevertheless exhibits extensive conformational heterogeneity, with ∼1 in 5 residues showing evidence for population of low energy alternative states. The holo G93A and E100G ALS mutants have moderately decreased global stability, whereas V148I is slightly stabilized. Comparison of the holo mutants as well as the marginally stable immature monomeric unmetalated and disulfide-reduced (apo(2SH)) pWT with holo pWT shows that changes in the local structural stability of individual amides vary greatly, with average changes corresponding to differences in global protein stability measured by differential scanning calorimetry. Mutants also exhibit altered conformational heterogeneity compared to pWT. Strikingly, substantial increases as well as decreases in local stability and conformational heterogeneity occur, in particular upon maturation and for G93A. Thus, the temperature-dependence of amide shifts for SOD1 variants is a rich source of information on the location and extent of perturbation of structure upon covalent changes and ligand binding. The implications for potential mechanisms of toxic misfolding of SOD1 in disease and for general aspects of protein energetics, including entropy-enthalpy compensation, are discussed.

Statistical evaluation of stability data: criteria for change-over-time and data variability.

PubMed

Bar, Raphael

2003-01-01

In a recently issued ICH Q1E guidance on evaluation of stability data of drug substances and products, the need to perform a statistical extrapolation of a shelf-life of a drug product or a retest period for a drug substance is based heavily on whether data exhibit a change-over-time and/or variability. However, this document suggests neither measures nor acceptance criteria of these two parameters. This paper demonstrates a useful application of simple statistical parameters for determining whether sets of stability data from either accelerated or long-term storage programs exhibit a change-over-time and/or variability. These parameters are all derived from a simple linear regression analysis first performed on the stability data. The p-value of the slope of the regression line is taken as a measure for change-over-time, and a value of 0.25 is suggested as a limit to insignificant change of the quantitative stability attributes monitored. The minimal process capability index, Cpk, calculated from the standard deviation of the regression line, is suggested as a measure for variability with a value of 2.5 as a limit for an insignificant variability. The usefulness of the above two parameters, p-value and Cpk, was demonstrated on stability data of a refrigerated drug product and on pooled data of three batches of a drug substance. In both cases, the determined parameters allowed characterization of the data in terms of change-over-time and variability. Consequently, complete evaluation of the stability data could be pursued according to the ICH guidance. It is believed that the application of the above two parameters with their acceptance criteria will allow a more unified evaluation of stability data.

Stability of streamwise vortices

NASA Technical Reports Server (NTRS)

Khorrami, M. K.; Grosch, C. E.; Ash, R. L.

1987-01-01

A brief overview of some theoretical and computational studies of the stability of streamwise vortices is given. The local induction model and classical hydrodynamic vortex stability theories are discussed in some detail. The importance of the three-dimensionality of the mean velocity profile to the results of stability calculations is discussed briefly. The mean velocity profile is provided by employing the similarity solution of Donaldson and Sullivan. The global method of Bridges and Morris was chosen for the spatial stability calculations for the nonlinear eigenvalue problem. In order to test the numerical method, a second order accurate central difference scheme was used to obtain the coefficient matrices. It was shown that a second order finite difference method lacks the required accuracy for global eigenvalue calculations. Finally the problem was formulated using spectral methods and a truncated Chebyshev series.

Establishment of a captive all-male group of proboscis monkey (Nasalis larvatus) at the Singapore Zoo.

PubMed

Sha, John Chih Mun; Alagappasamy, Sam; Chandran, Subash; Cho, Khin Maung; Guha, Biswajit

2013-01-01

Surplus male proboscis monkeys at the Singapore Zoo pose a considerable problem for maintenance and maximizing of exhibition potential. In 2008, a new exhibit was constructed to house and display a group of six proboscis monkey males born in Singapore Zoo. To document and monitor the all-male group establishment in the new exhibit, we conducted observations on intragroup interactions between the monkeys, spatial use of their new exhibit, and visitor effects on their behavior. We found contact aggressive interactions between the monkeys to be consistently lower than noncontact aggressive interactions and by week six of introduction to the new exhibit, contact aggression was almost nonevident. Affiliative interactions also developed between individuals in the group, with an interface of aggressive and socioreconcilatory behavior influenced by food competition and a dominance hierarchy. This was evident from significantly higher overall aggression and affiliation during feeding times compared to nonfeeding times, and this was reduced when food competition was mitigated by modifying the feeding regime. We measured the groups' spatial use of the exhibit and the relation to behavior, crowd size, and density. Our results showed that the proboscis monkeys utilized the available exhibit space, were largely unaffected by visitor crowd size and density, and were able to exhibit a variety of natural behaviors, including swimming. Our accomplishment in maintaining and displaying an all-male group of proboscis monkeys in captivity provides viable options for more comprehensive captive management and breeding programs for this endangered species. © 2012 Wiley Periodicals, Inc.

Structure and stability of the finite-area von Kármán street

NASA Astrophysics Data System (ADS)

Luzzatto-Fegiz, Paolo; Williamson, Charles H. K.

2012-06-01

By using a recently developed numerical method, we explore in detail the possible inviscid equilibrium flows for a Kármán street comprising uniform, large-area vortices. In order to determine stability, we make use of an energy-based stability argument (originally proposed by Lord Kelvin), whose previous implementation had been unsuccessful in determining stability for the Kármán street [P. G. Saffman and J. C. Schatzman, "Stability of a vortex street of finite vortices," J. Fluid Mech. 117, 171-186 (1982), 10.1017/S0022112082001578]. We discuss in detail the issues affecting this interpretation of Kelvin's ideas, and show that this energy-based argument cannot detect subharmonic instabilities. To find superharmonic instabilities, we employ a recently introduced approach, which constitutes a reliable implementation of Kelvin's stability ideas [P. Luzzatto-Fegiz and C. H. K. Williamson, "Stability of conservative flows and new steady fluid solutions from bifurcation diagrams exploiting a variational argument," Phys. Rev. Lett. 104, 044504 (2010), 10.1103/PhysRevLett.104.044504]. For periodic flows, this leads us to organize solutions into families with fixed impulse I, and to construct diagrams involving the flow energy E and horizontal spacing (i.e., wavelength) L. Families of large-I vortex streets exhibit a turning point in L, and terminate with "cat's eyes" vortices (as also suggested by previous investigators). However, for low-I streets, the solution families display a multitude of turning points (leading to multiple possible streets, for given L), and terminate with teardrop-shaped vortices. This is radically different from previous suggestions in the literature. These two qualitatively different limiting states are connected by a special street, whereby vortices from opposite rows touch, such that each vortex boundary exhibits three corners. Furthermore, by following the family of I = 0 streets to small L, we gain access to a large, hitherto unexplored flow regime, involving streets with L significantly smaller than previously believed possible. To elucidate in detail the possible solution regimes, we introduce a map of spacing L, versus impulse I, which we construct by numerically computing a large number of steady vortex configurations. For each constant-impulse family of steady vortices, our stability approach also reveals a single superharmonic bifurcation, leading to new families of vortex streets, which exhibit lower symmetry.

Studies of the conformational stability of invasion plasmid antigen B from Shigella

PubMed Central

Choudhari, Shyamal P; Kramer, Ryan; Barta, Michael L; Greenwood, Jamie C; Geisbrecht, Brian V; Joshi, Sangeeta B; Picking, William D; Middaugh, C Russell; Picking, Wendy L

2013-01-01

Shigella spp. are the causative agent of shigellosis, the second leading cause of diarrhea in children of ages 2–5. Despite many years of research, a protective vaccine has been elusive. We recently demonstrated that invasion plasmid antigens B and D (IpaB and IpaD) provide protection against S. flexneri and S. sonnei. These proteins, however, have very different properties which must be recognized and then managed during vaccine formulation. Herein, we employ spectroscopy to assess the stability of IpaB as well as IpgC (invasion protein gene), IpaB's cognate chaperone, and the IpaB/IpgC complex. The resulting data are mathematically summarized into a visual map illustrating the stability of the proteins and their complex as a function of pH and temperature. The IpaB/IpgC complex exhibits thermal stability at higher pH values but, though initially stable, quickly unfolds with increasing temperature when maintained at lower pH. In contrast, IpaB is a much more complex protein exhibiting increased stability at higher pH, but shows initial instability at lower pH values with pH 5 showing a distinct transition. IpgC precipitates at and below pH 5 and is stable above pH 7. Most strikingly, it is clear that complex formation results in stabilization of the two components. This work serves as a basis for the further development of IpaB as a vaccine candidate as well as extends our understanding of the structural stability of the Shigella type III secretion system. PMID:23494968

Stability of DIII-D high-performance, negative central shear discharges

DOE PAGES

Hanson, Jeremy M.; Berkery, John W.; Bialek, James M.; ...

2017-03-20

Tokamak plasma experiments on the DIII-D device demonstrate high-performance, negative central shear (NCS) equilibria with enhanced stability when the minimum safety factor q min exceeds 2, qualitatively confirming theoretical predictions of favorable stability in the NCS regime. The discharges exhibit good confinement with an L-mode enhancement factor H 89 = 2.5, and are ultimately limited by the ideal-wall external kink stability boundary as predicted by ideal MHD theory, as long as tearing mode (TM) locking events, resistive wall modes (RWMs), and internal kink modes are properly avoided or controlled. Although the discharges exhibit rotating TMs, locking events are avoided asmore » long as a threshold minimum safety factor value q min > 2 is maintained. Fast timescale magnetic feedback control ameliorates RWM activity, expanding the stable operating space and allowing access to β N values approaching the ideal-wall limit. Quickly growing and rotating instabilities consistent with internal kink mode dynamics are encountered when the ideal-wall limit is reached. The RWM events largely occur between the no- and ideal-wall pressure limits predicted by ideal MHD. However, evaluating kinetic contributions to the RWM dispersion relation results in a prediction of passive stability in this regime due to high plasma rotation. In addition, the ideal MHD stability analysis predicts that the ideal-wall limit can be further increased to β N > 4 by broadening the current profile. Furthermore, this path toward improved stability has the potential advantage of being compatible with the bootstrap-dominated equilibria envisioned for advanced tokamak (AT) fusion reactors.« less

Stability of DIII-D high-performance, negative central shear discharges

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hanson, Jeremy M.; Berkery, John W.; Bialek, James M.

Tokamak plasma experiments on the DIII-D device demonstrate high-performance, negative central shear (NCS) equilibria with enhanced stability when the minimum safety factor q min exceeds 2, qualitatively confirming theoretical predictions of favorable stability in the NCS regime. The discharges exhibit good confinement with an L-mode enhancement factor H 89 = 2.5, and are ultimately limited by the ideal-wall external kink stability boundary as predicted by ideal MHD theory, as long as tearing mode (TM) locking events, resistive wall modes (RWMs), and internal kink modes are properly avoided or controlled. Although the discharges exhibit rotating TMs, locking events are avoided asmore » long as a threshold minimum safety factor value q min > 2 is maintained. Fast timescale magnetic feedback control ameliorates RWM activity, expanding the stable operating space and allowing access to β N values approaching the ideal-wall limit. Quickly growing and rotating instabilities consistent with internal kink mode dynamics are encountered when the ideal-wall limit is reached. The RWM events largely occur between the no- and ideal-wall pressure limits predicted by ideal MHD. However, evaluating kinetic contributions to the RWM dispersion relation results in a prediction of passive stability in this regime due to high plasma rotation. In addition, the ideal MHD stability analysis predicts that the ideal-wall limit can be further increased to β N > 4 by broadening the current profile. Furthermore, this path toward improved stability has the potential advantage of being compatible with the bootstrap-dominated equilibria envisioned for advanced tokamak (AT) fusion reactors.« less

Enhanced aging properties of HKUST-1 in hydrophobic mixed-matrix membranes for ammonia adsorption† †Electronic supplementary information (ESI) available: Experimental procedures. See DOI: 10.1039/c5sc04368a Click here for additional data file.

PubMed Central

Denny, Jr., Michael S.; Peterson, Gregory W.; Mahle, John J.

2016-01-01

Metal–organic frameworks (MOFs) in their free powder form have exhibited superior capacities for many gases when compared to other materials, due to their tailorable functionality and high surface areas. Specifically, the MOF HKUST-1 binds small Lewis bases, such as ammonia, with its coordinatively unsaturated copper sites. We describe here the use of HKUST-1 in mixed-matrix membranes (MMMs) prepared from polyvinylidene difluoride (PVDF) for the removal of ammonia gas. These MMMs exhibit ammonia capacities similar to their hypothetical capacities based on the weight percent of HKUST-1 in each MMM. HKUST-1 in its powder form is unstable toward humid conditions; however, upon exposure to humid environments for prolonged periods of time, the HKUST-1 MMMs exhibit outstanding structural stability, and maintain their ammonia capacity. Overall, this study has achieved all of the critical and combined elements for real-world applications of MOFs: high MOF loadings, fully accessible MOF surfaces, enhanced MOF stabilization, recyclability, mechanical stability, and processability. This study is a critical step in advancing MOFs to a stable, usable, and enabling technology. PMID:28660045

Stability analysis and trend study of a balloon tethered in a wind, with experimental comparisons

NASA Technical Reports Server (NTRS)

Redd, L. T.; Bland, S. R.; Bennett, R. M.

1973-01-01

A stability analysis and trend study for a balloon tethered in a steady wind are presented. The linearized, stability-derivative type analysis includes balloon aerodynamics, buoyancy, mass (including apparent mass), and static forces resulting from the tether cable. The analysis has been applied to a balloon 7.64 m in length, and the results are compared with those from tow tests of this balloon. This comparison shows that the analysis gives reasonable predictions for the damping, frequencies, modes of motion, and stability boundaries exhibited by the balloon. A trend study for the 7.64-m balloon was made to illustrate how the stability boundaries are affected by changes in individual stability parameters. The trends indicated in this study may also be applicable to many other tethered-balloon systems.

Can the functional stability of forest ecosystems be evaluated from the spatial analysis of stands? A case study from the Bialowieza Primeval Forest (Poland)

Treesearch

Andrzej Bobiec

2000-01-01

Variability of external and internal factors entails specific spatial patterns and functional dynamics of communities. The study of the oak-lime-hornbeam (Quercus robur-Tilia cordata-Carpimus) forest in the Bialowieza Primeval Forest supports the concept of silvatic unit, determining the minimal structural area. To find out if the dynamics of a stand...

Determining Selection across Heterogeneous Landscapes: A Perturbation-Based Method and Its Application to Modeling Evolution in Space.

PubMed

Wickman, Jonas; Diehl, Sebastian; Blasius, Bernd; Klausmeier, Christopher A; Ryabov, Alexey B; Brännström, Åke

2017-04-01

Spatial structure can decisively influence the way evolutionary processes unfold. To date, several methods have been used to study evolution in spatial systems, including population genetics, quantitative genetics, moment-closure approximations, and individual-based models. Here we extend the study of spatial evolutionary dynamics to eco-evolutionary models based on reaction-diffusion equations and adaptive dynamics. Specifically, we derive expressions for the strength of directional and stabilizing/disruptive selection that apply both in continuous space and to metacommunities with symmetrical dispersal between patches. For directional selection on a quantitative trait, this yields a way to integrate local directional selection across space and determine whether the trait value will increase or decrease. The robustness of this prediction is validated against quantitative genetics. For stabilizing/disruptive selection, we show that spatial heterogeneity always contributes to disruptive selection and hence always promotes evolutionary branching. The expression for directional selection is numerically very efficient and hence lends itself to simulation studies of evolutionary community assembly. We illustrate the application and utility of the expressions for this purpose with two examples of the evolution of resource utilization. Finally, we outline the domain of applicability of reaction-diffusion equations as a modeling framework and discuss their limitations.

Image Stability Requirements For a Geostationary Imaging Fourier Transform Spectrometer (GIFTS)

NASA Technical Reports Server (NTRS)

Bingham, G. E.; Cantwell, G.; Robinson, R. C.; Revercomb, H. E.; Smith, W. L.

2001-01-01

A Geostationary Imaging Fourier Transform Spectrometer (GIFTS) has been selected for the NASA New Millennium Program (NMP) Earth Observing-3 (EO-3) mission. Our paper will discuss one of the key GIFTS measurement requirements, Field of View (FOV) stability, and its impact on required system performance. The GIFTS NMP mission is designed to demonstrate new and emerging sensor and data processing technologies with the goal of making revolutionary improvements in meteorological observational capability and forecasting accuracy. The GIFTS payload is a versatile imaging FTS with programmable spectral resolution and spatial scene selection that allows radiometric accuracy and atmospheric sounding precision to be traded in near real time for area coverage. The GIFTS sensor combines high sensitivity with a massively parallel spatial data collection scheme to allow high spatial resolution measurement of the Earth's atmosphere and rapid broad area coverage. An objective of the GIFTS mission is to demonstrate the advantages of high spatial resolution (4 km ground sample distance - gsd) on temperature and water vapor retrieval by allowing sampling in broken cloud regions. This small gsd, combined with the relatively long scan time required (approximately 10 s) to collect high resolution spectra from geostationary (GEO) orbit, may require extremely good pointing control. This paper discusses the analysis of this requirement.

Double-plasma enhanced carbon shield for spatial/interfacial controlled electrodes in lithium ion batteries via micro-sized silicon from wafer waste

NASA Astrophysics Data System (ADS)

Chen, Bing-Hong; Chuang, Shang-I.; Duh, Jenq-Gong

2016-11-01

Using spatial and interfacial control, the micro-sized silicon waste from wafer slurry could greatly increase its retention potential as a green resource for silicon-based anode in lithium ion batteries. Through step by step spatial and interfacial control for electrode, the cyclability of recycled waste gains potential performance from its original poor retention property. In the stages of spatial control, the electrode stabilizers of active, inactive and conductive additives were mixed into slurries for maintaining architecture and conductivity of electrode. In addition, a fusion electrode modification of interfacial control combines electrolyte additive, technique of double-plasma enhanced carbon shield (D-PECS) to convert the chemical bond states and to alter the formation of solid electrolyte interphases (SEIs) in the first cycle. The depth profiles of chemical composition from external into internal electrode illustrate that the fusion electrode modification not only forms a boundary to balance the interface between internal and external electrodes but also stabilizes the SEIs formation and soothe the expansion of micro-sized electrode. Through these effect approaches, the performance of micro-sized Si waste electrode can be boosted from its serious capacity degradation to potential retention (200 cycles, 1100 mAh/g) and better meet the requirements for facile and cost-effective in industrial production.

Novel probabilistic models of spatial genetic ancestry with applications to stratification correction in genome-wide association studies.

PubMed

Bhaskar, Anand; Javanmard, Adel; Courtade, Thomas A; Tse, David

2017-03-15

Genetic variation in human populations is influenced by geographic ancestry due to spatial locality in historical mating and migration patterns. Spatial population structure in genetic datasets has been traditionally analyzed using either model-free algorithms, such as principal components analysis (PCA) and multidimensional scaling, or using explicit spatial probabilistic models of allele frequency evolution. We develop a general probabilistic model and an associated inference algorithm that unify the model-based and data-driven approaches to visualizing and inferring population structure. Our spatial inference algorithm can also be effectively applied to the problem of population stratification in genome-wide association studies (GWAS), where hidden population structure can create fictitious associations when population ancestry is correlated with both the genotype and the trait. Our algorithm Geographic Ancestry Positioning (GAP) relates local genetic distances between samples to their spatial distances, and can be used for visually discerning population structure as well as accurately inferring the spatial origin of individuals on a two-dimensional continuum. On both simulated and several real datasets from diverse human populations, GAP exhibits substantially lower error in reconstructing spatial ancestry coordinates compared to PCA. We also develop an association test that uses the ancestry coordinates inferred by GAP to accurately account for ancestry-induced correlations in GWAS. Based on simulations and analysis of a dataset of 10 metabolic traits measured in a Northern Finland cohort, which is known to exhibit significant population structure, we find that our method has superior power to current approaches. Our software is available at https://github.com/anand-bhaskar/gap . abhaskar@stanford.edu or ajavanma@usc.edu. Supplementary data are available at Bioinformatics online. © The Author 2016. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com

Characterization of neurophysiologic and neurocognitive biomarkers for use in genomic and clinical outcome studies of schizophrenia.

PubMed

Light, Gregory A; Swerdlow, Neal R; Rissling, Anthony J; Radant, Allen; Sugar, Catherine A; Sprock, Joyce; Pela, Marlena; Geyer, Mark A; Braff, David L

2012-01-01

Endophenotypes are quantitative, laboratory-based measures representing intermediate links in the pathways between genetic variation and the clinical expression of a disorder. Ideal endophenotypes exhibit deficits in patients, are stable over time and across shifts in psychopathology, and are suitable for repeat testing. Unfortunately, many leading candidate endophenotypes in schizophrenia have not been fully characterized simultaneously in large cohorts of patients and controls across these properties. The objectives of this study were to characterize the extent to which widely-used neurophysiological and neurocognitive endophenotypes are: 1) associated with schizophrenia, 2) stable over time, independent of state-related changes, and 3) free of potential practice/maturation or differential attrition effects in schizophrenia patients (SZ) and nonpsychiatric comparison subjects (NCS). Stability of clinical and functional measures was also assessed. Participants (SZ n = 341; NCS n = 205) completed a battery of neurophysiological (MMN, P3a, P50 and N100 indices, PPI, startle habituation, antisaccade), neurocognitive (WRAT-3 Reading, LNS-forward, LNS-reorder, WCST-64, CVLT-II). In addition, patients were rated on clinical symptom severity as well as functional capacity and status measures (GAF, UPSA, SOF). 223 subjects (SZ n = 163; NCS n = 58) returned for retesting after 1 year. Most neurophysiological and neurocognitive measures exhibited medium-to-large deficits in schizophrenia, moderate-to-substantial stability across the retest interval, and were independent of fluctuations in clinical status. Clinical symptoms and functional measures also exhibited substantial stability. A Longitudinal Endophenotype Ranking System (LERS) was created to rank neurophysiological and neurocognitive biomarkers according to their effect sizes across endophenotype criteria. The majority of neurophysiological and neurocognitive measures exhibited deficits in patients, stability over a 1-year interval and did not demonstrate practice or time effects supporting their use as endophenotypes in neural substrate and genomic studies. These measures hold promise for informing the "gene-to-phene gap" in schizophrenia research.

Characterization of Neurophysiologic and Neurocognitive Biomarkers for Use in Genomic and Clinical Outcome Studies of Schizophrenia

PubMed Central

Light, Gregory A.; Swerdlow, Neal R.; Rissling, Anthony J.; Radant, Allen; Sugar, Catherine A.; Sprock, Joyce; Pela, Marlena; Geyer, Mark A.; Braff, David L.

2012-01-01

Background Endophenotypes are quantitative, laboratory-based measures representing intermediate links in the pathways between genetic variation and the clinical expression of a disorder. Ideal endophenotypes exhibit deficits in patients, are stable over time and across shifts in psychopathology, and are suitable for repeat testing. Unfortunately, many leading candidate endophenotypes in schizophrenia have not been fully characterized simultaneously in large cohorts of patients and controls across these properties. The objectives of this study were to characterize the extent to which widely-used neurophysiological and neurocognitive endophenotypes are: 1) associated with schizophrenia, 2) stable over time, independent of state-related changes, and 3) free of potential practice/maturation or differential attrition effects in schizophrenia patients (SZ) and nonpsychiatric comparison subjects (NCS). Stability of clinical and functional measures was also assessed. Methods Participants (SZ n = 341; NCS n = 205) completed a battery of neurophysiological (MMN, P3a, P50 and N100 indices, PPI, startle habituation, antisaccade), neurocognitive (WRAT-3 Reading, LNS-forward, LNS-reorder, WCST-64, CVLT-II). In addition, patients were rated on clinical symptom severity as well as functional capacity and status measures (GAF, UPSA, SOF). 223 subjects (SZ n = 163; NCS n = 58) returned for retesting after 1 year. Results Most neurophysiological and neurocognitive measures exhibited medium-to-large deficits in schizophrenia, moderate-to-substantial stability across the retest interval, and were independent of fluctuations in clinical status. Clinical symptoms and functional measures also exhibited substantial stability. A Longitudinal Endophenotype Ranking System (LERS) was created to rank neurophysiological and neurocognitive biomarkers according to their effect sizes across endophenotype criteria. Conclusions The majority of neurophysiological and neurocognitive measures exhibited deficits in patients, stability over a 1-year interval and did not demonstrate practice or time effects supporting their use as endophenotypes in neural substrate and genomic studies. These measures hold promise for informing the “gene-to-phene gap” in schizophrenia research. PMID:22802938

Colour stabilities of three types of orthodontic clear aligners exposed to staining agents

PubMed Central

Liu, Chen-Lu; Sun, Wen-Tian; Liao, Wen; Lu, Wen-Xin; Li, Qi-Wen; Jeong, Yunho; Liu, Jun; Zhao, Zhi-He

2016-01-01

The aim of this study was to evaluate and compare the colour stabilities of three types of orthodontic clear aligners exposed to staining agents in vitro. Sixty clear orthodontic aligners produced by three manufacturers (Invisalign, Angelalign, and Smartee) were immersed in three staining solutions (coffee, black tea, and red wine) and one control solution (distilled water). After 12-h and 7-day immersions, the aligners were washed in an ultrasonic cleaner and measured with a colourimeter. The colour changes (ΔE*) were calculated on the basis of the Commission Internationale de I'Eclairage L*a*b* colour system (CIE L*a*b*), and the results were then converted into National Bureau of Standards (NBS) units. Fourier transformation infrared (FT-IR) spectroscopy and scanning electron microscopy (SEM) were conducted to observe the molecular and morphologic alterations to the aligner surfaces, respectively. The three types of aligners exhibited slight colour changes after 12 h of staining, with the exception of the Invisalign aligners stained with coffee. The Invisalign aligners exhibited significantly higher ΔE* values (ranging from 0.30 to 27.81) than those of the Angelalign and Smartee aligners (ΔE* values ranging from 0.33 to 1.89 and 0.32 to 1.61, respectively, P<0.05). FT-IR analysis confirmed that the polymer-based structure of aligners did not exhibit significant chemical differences before and after the immersions. The SEM results revealed different surface alterations to the three types of aligner materials after the 7-day staining. The three types of aesthetic orthodontic appliances exhibited colour stability after the 12-h immersion, with the exception of the Invisalign aligners stained by coffee. The Invisalign aligners were more prone than the Angelalign and Smartee aligners to pigmentation. Aligner materials may be improved by considering aesthetic colour stability properties. PMID:27660048

Colour stabilities of three types of orthodontic clear aligners exposed to staining agents.

PubMed

Liu, Chen-Lu; Sun, Wen-Tian; Liao, Wen; Lu, Wen-Xin; Li, Qi-Wen; Jeong, Yunho; Liu, Jun; Zhao, Zhi-He

2016-12-16

The aim of this study was to evaluate and compare the colour stabilities of three types of orthodontic clear aligners exposed to staining agents in vitro. Sixty clear orthodontic aligners produced by three manufacturers (Invisalign, Angelalign, and Smartee) were immersed in three staining solutions (coffee, black tea, and red wine) and one control solution (distilled water). After 12-h and 7-day immersions, the aligners were washed in an ultrasonic cleaner and measured with a colourimeter. The colour changes (ΔE*) were calculated on the basis of the Commission Internationale de I'Eclairage L*a*b* colour system (CIE L*a*b*), and the results were then converted into National Bureau of Standards (NBS) units. Fourier transformation infrared (FT-IR) spectroscopy and scanning electron microscopy (SEM) were conducted to observe the molecular and morphologic alterations to the aligner surfaces, respectively. The three types of aligners exhibited slight colour changes after 12 h of staining, with the exception of the Invisalign aligners stained with coffee. The Invisalign aligners exhibited significantly higher ΔE* values (ranging from 0.30 to 27.81) than those of the Angelalign and Smartee aligners (ΔE* values ranging from 0.33 to 1.89 and 0.32 to 1.61, respectively, P<0.05). FT-IR analysis confirmed that the polymer-based structure of aligners did not exhibit significant chemical differences before and after the immersions. The SEM results revealed different surface alterations to the three types of aligner materials after the 7-day staining. The three types of aesthetic orthodontic appliances exhibited colour stability after the 12-h immersion, with the exception of the Invisalign aligners stained by coffee. The Invisalign aligners were more prone than the Angelalign and Smartee aligners to pigmentation. Aligner materials may be improved by considering aesthetic colour stability properties.

Characterization of Femoral Component Initial Stability and Cortical Strain in a Reduced Stem-Length Design.

PubMed

Small, Scott R; Hensley, Sarah E; Cook, Paige L; Stevens, Rebecca A; Rogge, Renee D; Meding, John B; Berend, Michael E

2017-02-01

Short-stemmed femoral components facilitate reduced exposure surgical techniques while preserving native bone. A clinically successful stem should ideally reduce risk for stress shielding while maintaining adequate primary stability for biological fixation. We asked (1) how stem-length changes cortical strain distribution in the proximal femur in a fit-and-fill geometry and (2) if short-stemmed components exhibit primary stability on par with clinically successful designs. Cortical strain was assessed via digital image correlation in composite femurs implanted with long, medium, and short metaphyseal fit-and-fill stem designs in a single-leg stance loading model. Strain was compared to a loaded, unimplanted femur. Bone-implant micromotion was then compared with reduced lateral shoulder short stem and short tapered-wedge designs in cyclic axial and torsional testing. Femurs implanted with short-stemmed components exhibited cortical strain response most closely matching that of the intact femur model, theoretically reducing the potential for proximal stress shielding. In micromotion testing, no difference in primary stability was observed as a function of reduced stem length within the same component design. Our findings demonstrate that within this fit-and-fill stem design, reduction in stem length improved proximal cortical strain distribution and maintained axial and torsional stability on par with other stem designs in a composite femur model. Short-stemmed implants may accommodate less invasive surgical techniques while facilitating more physiological femoral loading without sacrificing primary implant stability. Copyright © 2016 Elsevier Inc. All rights reserved.

Stability of equilibrium solutions of Hamiltonian systems with n-degrees of freedom and single resonance in the critical case

NASA Astrophysics Data System (ADS)

dos Santos, Fabio; Vidal, Claudio

2018-04-01

In this paper we give new results for the stability of one equilibrium solution of an autonomous analytic Hamiltonian system in a neighborhood of the equilibrium point with n-degrees of freedom. Our Main Theorem generalizes several results existing in the literature and mainly we give information in the critical cases (i.e., the condition of stability and instability is not fulfilled). In particular, our Main Theorem provides necessary and sufficient conditions for stability of the equilibrium solutions under the existence of a single resonance. Using analogous tools used in the Main Theorem for the critical case, we study the stability or instability of degenerate equilibrium points in Hamiltonian systems with one degree of freedom. We apply our results to the stability of Hamiltonians of the type of cosmological models as in planar as in the spatial case.

Photometric Repeatability of Scanned Imagery: UVIS

NASA Astrophysics Data System (ADS)

Shanahan, Clare E.; McCullough, Peter; Baggett, Sylvia

2017-08-01

We provide the preliminary results of a study on the photometric repeatability of spatial scans of bright, isolated white dwarf stars with the UVIS channel of the Wide Field Camera 3 (WFC3) on the Hubble Space Telescope (HST). We analyze straight-line scans from the first pair of identical orbits of HST program 14878 to assess if sub 0.1% repeatability can be attained with WFC3/UVIS. This study is motivated by the desire to achieve better signal-to-noise in the UVIS contamination and stability monitor, in which observations of standard stars in staring mode have been taken from the installation of WFC3 in 2009 to the present to assess temporal photometric stability. Higher signal to noise in this program would greatly benefit the sensitivity to detect contamination, and to better characterize the observed small throughput drifts over time. We find excellent repeatability between identical visits of program 14878, with sub 0.1% repeatability achieved in most filters. These! results support the initiative to transition the staring mode UVIS contamination and photometric stability monitor from staring mode images to spatial scans.

The CFL condition for spectral approximations to hyperbolic initial-boundary value problems

NASA Technical Reports Server (NTRS)

Gottlieb, David; Tadmor, Eitan

1991-01-01

The stability of spectral approximations to scalar hyperbolic initial-boundary value problems with variable coefficients are studied. Time is discretized by explicit multi-level or Runge-Kutta methods of order less than or equal to 3 (forward Euler time differencing is included), and spatial discretizations are studied by spectral and pseudospectral approximations associated with the general family of Jacobi polynomials. It is proved that these fully explicit spectral approximations are stable provided their time-step, delta t, is restricted by the CFL-like condition, delta t less than Const. N(exp-2), where N equals the spatial number of degrees of freedom. We give two independent proofs of this result, depending on two different choices of approximate L(exp 2)-weighted norms. In both approaches, the proofs hinge on a certain inverse inequality interesting for its own sake. The result confirms the commonly held belief that the above CFL stability restriction, which is extensively used in practical implementations, guarantees the stability (and hence the convergence) of fully-explicit spectral approximations in the nonperiodic case.

The CFL condition for spectral approximations to hyperbolic initial-boundary value problems

NASA Technical Reports Server (NTRS)

Gottlieb, David; Tadmor, Eitan

1990-01-01

The stability of spectral approximations to scalar hyperbolic initial-boundary value problems with variable coefficients are studied. Time is discretized by explicit multi-level or Runge-Kutta methods of order less than or equal to 3 (forward Euler time differencing is included), and spatial discretizations are studied by spectral and pseudospectral approximations associated with the general family of Jacobi polynomials. It is proved that these fully explicit spectral approximations are stable provided their time-step, delta t, is restricted by the CFL-like condition, delta t less than Const. N(exp-2), where N equals the spatial number of degrees of freedom. We give two independent proofs of this result, depending on two different choices of approximate L(exp 2)-weighted norms. In both approaches, the proofs hinge on a certain inverse inequality interesting for its own sake. The result confirms the commonly held belief that the above CFL stability restriction, which is extensively used in practical implementations, guarantees the stability (and hence the convergence) of fully-explicit spectral approximations in the nonperiodic case.

Position-sensitive proportional counter with low-resistance metal-wire anode

DOEpatents

Kopp, Manfred K.

1980-01-01

A position-sensitive proportional counter circuit is provided which allows the use of a conventional (low-resistance, metal-wire anode) proportional counter for spatial resolution of an ionizing event along the anode of the counter. A pair of specially designed active-capacitance preamplifiers are used to terminate the anode ends wherein the anode is treated as an RC line. The preamplifiers act as stabilized active capacitance loads and each is composed of a series-feedback, low-noise amplifier, a unity-gain, shunt-feedback amplifier whose output is connected through a feedback capacitor to the series-feedback amplifier input. The stabilized capacitance loading of the anode allows distributed RC-line position encoding and subsequent time difference decoding by sensing the difference in rise times of pulses at the anode ends where the difference is primarily in response to the distributed capacitance along the anode. This allows the use of lower resistance wire anodes for spatial radiation detection which simplifies the counter construction and handling of the anodes, and stabilizes the anode resistivity at high count rates (>10.sup.6 counts/sec).

Analysis of spatial-temporal patterns of water table change as a tool for conjunctive water management in the Upper Central Plain of the Chao Phraya River Basin, Thailand

NASA Astrophysics Data System (ADS)

Vasconcelos, Vitor Vieira; Koontanakulvong, Sucharit; Suthidhummajit, Chokchai; Junior, Paulo Pereira Martins; Hadad, Renato Moreira

2017-03-01

A sustainable strategy for conjunctive water management must include information on the temporal and spatial availability of this natural resource. Because of water shortages in the dry seasons, farmers on the Upper Plain of the Chao Phraya River basin, Thailand, are increasingly using groundwater to meet their irrigation needs. To evaluate the possibilities of conjunctive water management in the area, the spatial-temporal changes in the water table of the Younger Terrace Aquifer were investigated. First, a regional geomorphological map based on field surveys, remote sensing and previous environmental studies was developed. Then, the well data were analyzed in relation to rainfall, streamflow, yield and pumpage, and the data were interpolated using geostatistical techniques. The results were analyzed via integrated zoning based on color theory as applied to multivariate visualization. The analysis results indicate areas that would be more suitable for groundwater extraction in a conjunctive management framework with regard to the natural hydrogeological processes and the effects of human interaction. The kriging results were compared with the geomorphological map, and the geomorphological areas exhibit distinct hydrogeological patterns. The western fans exhibit the best potential for the expansion of conjunctive use, whereas the borders of the northern fans exhibit the lowest potential.

A Study of the Microbial Spatial Heterogeneity of Bahamian Thrombolites Using Molecular, Biochemical, and Stable Isotope Analyses

NASA Astrophysics Data System (ADS)

Louyakis, Artemis S.; Mobberley, Jennifer M.; Vitek, Brooke E.; Visscher, Pieter T.; Hagan, Paul D.; Reid, R. Pamela; Kozdon, Reinhard; Orland, Ian J.; Valley, John W.; Planavsky, Noah J.; Casaburi, Giorgio; Foster, Jamie S.

2017-05-01

Thrombolites are buildups of carbonate that exhibit a clotted internal structure formed through the interactions of microbial mats and their environment. Despite recent advances, we are only beginning to understand the microbial and molecular processes associated with their formation. In this study, a spatial profile of the microbial and metabolic diversity of thrombolite-forming mats of Highborne Cay, The Bahamas, was generated by using 16S rRNA gene sequencing and predictive metagenomic analyses. These molecular-based approaches were complemented with microelectrode profiling and in situ stable isotope analysis to examine the dominant taxa and metabolic activities within the thrombolite-forming communities. Analyses revealed three distinctive zones within the thrombolite-forming mats that exhibited stratified populations of bacteria and archaea. Predictive metagenomics also revealed vertical profiles of metabolic capabilities, such as photosynthesis and carboxylic and fatty acid synthesis within the mats that had not been previously observed. The carbonate precipitates within the thrombolite-forming mats exhibited isotopic geochemical signatures suggesting that the precipitation within the Bahamian thrombolites is photosynthetically induced. Together, this study provides the first look at the spatial organization of the microbial populations within Bahamian thrombolites and enables the distribution of microbes to be correlated with their activities within modern thrombolite systems.

Spatial aspects of prebiotic replicator coexistence and community stability in a surface-bound RNA world model

PubMed Central

2013-01-01

Background The coexistence of macromolecular replicators and thus the stability of presumed prebiotic replicator communities have been shown to critically depend on spatially constrained catalytic cooperation among RNA-like modular replicators. The necessary spatial constraints might have been supplied by mineral surfaces initially, preceding the more effective compartmentalization in membrane vesicles which must have been a later development of chemical evolution. Results Using our surface-bound RNA world model – the Metabolic Replicator Model (MRM) platform – we show that the mobilities on the mineral substrate surface of both the macromolecular replicators and the small molecules of metabolites they produce catalytically are the key factors determining the stable persistence of an evolvable metabolic replicator community. Conclusion The effects of replicator mobility and metabolite diffusion on different aspects of replicator coexistence in MRM are determined, including the maximum attainable size of the metabolic replicator system and its resistance to the invasion of parasitic replicators. We suggest a chemically plausible hypothetical scenario for the evolution of the first protocell starting from the surface-bound MRM system. PMID:24053177

A dynamical system approach to Bianchi III cosmology for Hu-Sawicki type f( R) gravity

NASA Astrophysics Data System (ADS)

Banik, Sebika Kangsha; Banik, Debika Kangsha; Bhuyan, Kalyan

2018-02-01

The cosmological dynamics of spatially homogeneous but anisotropic Bianchi type-III space-time is investigated in presence of a perfect fluid within the framework of Hu-Sawicki model. We use the dynamical system approach to perform a detailed analysis of the cosmological behaviour of this model for the model parameters n=1, c_1=1, determining all the fixed points, their stability and corresponding cosmological evolution. We have found stable fixed points with de Sitter solution along with unstable radiation like fixed points. We have identified a matter like point which act like an unstable spiral and when the initial conditions of a trajectory are very close to this point, it stabilizes at a stable accelerating point. Thus, in this model, the universe can naturally approach to a phase of accelerated expansion following a radiation or a matter dominated phase. It is also found that the isotropisation of this model is affected by the spatial curvature and that all the isotropic fixed points are found to be spatially flat.

A Dynamic Hydrology-Critical Zone Framework for Rainfall-triggered Landslide Hazard Prediction

NASA Astrophysics Data System (ADS)

Dialynas, Y. G.; Foufoula-Georgiou, E.; Dietrich, W. E.; Bras, R. L.

2017-12-01

Watershed-scale coupled hydrologic-stability models are still in their early stages, and are characterized by important limitations: (a) either they assume steady-state or quasi-dynamic watershed hydrology, or (b) they simulate landslide occurrence based on a simple one-dimensional stability criterion. Here we develop a three-dimensional landslide prediction framework, based on a coupled hydrologic-slope stability model and incorporation of the influence of deep critical zone processes (i.e., flow through weathered bedrock and exfiltration to the colluvium) for more accurate prediction of the timing, location, and extent of landslides. Specifically, a watershed-scale slope stability model that systematically accounts for the contribution of driving and resisting forces in three-dimensional hillslope segments was coupled with a spatially-explicit and physically-based hydrologic model. The landslide prediction framework considers critical zone processes and structure, and explicitly accounts for the spatial heterogeneity of surface and subsurface properties that control slope stability, including soil and weathered bedrock hydrological and mechanical characteristics, vegetation, and slope morphology. To test performance, the model was applied in landslide-prone sites in the US, the hydrology of which has been extensively studied. Results showed that both rainfall infiltration in the soil and groundwater exfiltration exert a strong control on the timing and magnitude of landslide occurrence. We demonstrate the extent to which three-dimensional slope destabilizing factors, which are modulated by dynamic hydrologic conditions in the soil-bedrock column, control landslide initiation at the watershed scale.

The stability of stratified spatially periodic shear flows at low Péclet number

DOE Office of Scientific and Technical Information (OSTI.GOV)

Garaud, Pascale, E-mail: pgaraud@ucsc.edu; Gallet, Basile; Bischoff, Tobias

2015-08-15

This work addresses the question of the stability of stratified, spatially periodic shear flows at low Péclet number but high Reynolds number. This little-studied limit is motivated by astrophysical systems, where the Prandtl number is often very small. Furthermore, it can be studied using a reduced set of “low-Péclet-number equations” proposed by Lignières [“The small-Péclet-number approximation in stellar radiative zones,” Astron. Astrophys. 348, 933–939 (1999)]. Through a linear stability analysis, we first determine the conditions for instability to infinitesimal perturbations. We formally extend Squire’s theorem to the low-Péclet-number equations, which shows that the first unstable mode is always two-dimensional. Wemore » then perform an energy stability analysis of the low-Péclet-number equations and prove that for a given value of the Reynolds number, above a critical strength of the stratification, any smooth periodic shear flow is stable to perturbations of arbitrary amplitude. In that parameter regime, the flow can only be laminar and turbulent mixing does not take place. Finding that the conditions for linear and energy stability are different, we thus identify a region in parameter space where finite-amplitude instabilities could exist. Using direct numerical simulations, we indeed find that the system is subject to such finite-amplitude instabilities. We determine numerically how far into the linearly stable region of parameter space turbulence can be sustained.« less

Hybrid Control for Multi-Agent Systems in Complex Sensing Environments

DTIC Science & Technology

2012-02-28

controllers , the overall closed-loop system is time -varying but can potentially exhibit better stability and performance... system is time -varying and yet, once 4 feedback-interconnected with a suitable controller , it can potentially yield better stability and performance...resolution Sensing, Control and Switched Systems 13 4 Metric-Based Receding Horizon Control 14 5 Decentralized Control and Finite Wordlength Channels 15

Synthesis of Perfluorinated Polymers

NASA Technical Reports Server (NTRS)

Rosser, R. W.; Psarras, T.

1982-01-01

Long-chain perfluoropolyethers containing functional pendent groups were investigated as possible candidates for new sealants and elastomers that function in extreme environments. Of specific interest was development of materials exhibiting high thermal and oxidative stability at temperatures around 400 degrees C, low-temperature flexibility with glass transition at about 50 degrees C, and hydrolytic stability as well as compatibility with metals and resistance to fuels.

Organic thin film devices with stabilized threshold voltage and mobility, and method for preparing the devices

DOEpatents

Nastasi, Michael Anthony; Wang, Yongqiang; Fraboni, Beatrice; Cosseddu, Piero; Bonfiglio, Annalisa

2013-06-11

Organic thin film devices that included an organic thin film subjected to a selected dose of a selected energy of ions exhibited a stabilized mobility (.mu.) and threshold voltage (VT), a decrease in contact resistance R.sub.C, and an extended operational lifetime that did not degrade after 2000 hours of operation in the air.

Fabrication and Characterization of Quinoa Protein Nanoparticle-Stabilized Food-Grade Pickering Emulsions with Ultrasound Treatment: Interfacial Adsorption/Arrangement Properties.

PubMed

Qin, Xin-Sheng; Luo, Zhi-Gang; Peng, Xi-Chun

2018-05-02

The natural quinoa protein isolate (QPI) was largely reflected in the nanoparticle form at pH 7.0 (∼401 nm), and the ultrasound at 20 min progressively improved the contact angle (wettability) and surface hydrophobicity of the nanoparticles. Ultrasound process also modified the type of intraparticle interaction, and the internal forces of sonicated particles were largely maintained by both disulfide bonds and hydrophobic interaction forces. In emulsion system, the ultrasound progressively increased the emulsification efficiency of the QPI nanoparticles, particularly at high protein concentration ( c > 1%, w/ v) and higher emulsion stability against coalescence. As compared with the natural QPI-stabilized emulsions, the 20 min sonicated emulsions exhibited higher packing and adsorption at the protein interface. The microstructure of emulsions that occurs is bridging flocculation of droplets at low c (≤1%, w/ v), while the amount of protein particles could be high enough to cover the droplet surface at high c ( >1%, w/ v) with hexagonal array model arrangement. Thus these results illustrated that both natural and sonicated QPI nanoparticles could be performed as effective food-grade stabilizer for Pickering emulsion; however, the sonicated QPI nanoparticles exhibited much better emulsifying and interfacial properties.

Dynamics of Orbits near 3:1 Resonance in the Earth-Moon System

NASA Technical Reports Server (NTRS)

Dichmann, Donald J.; Lebois, Ryan; Carrico, John P., Jr.

2013-01-01

The Interstellar Boundary Explorer (IBEX) spacecraft is currently in a highly elliptical orbit around Earth with a period near 3:1 resonance with the Moon. Its orbit is oriented so that apogee does not approach the Moon. Simulations show this orbit to be remarkably stable over the next twenty years. This article examines the dynamics of such orbits in the Circular Restricted 3-Body Problem (CR3BP). We look at three types of periodic orbits, each exhibiting a type of symmetry of the CR3BP. For each of the orbit types, we assess the local stability using Floquet analysis. Although not all of the periodic solutions are stable in the mathematical sense, any divergence is so slow as to produce practical stability over several decades. We use Poincare maps with twenty-year propagations to assess the nonlinear stability of the orbits, where the perturbation magnitudes are related to the orbit uncertainty for the IBEX mission. Finally we show that these orbits belong to a family of orbits connected in a bifurcation diagram that exhibits exchange of stability. The analysis of these families of period orbits provides a valuable starting point for a mission orbit trade study.

Ultrasonic-assisted synthesis of ZrO2 nanoparticles and their application to improve the chemical stability of Nafion membrane in proton exchange membrane (PEM) fuel cells.

PubMed

Taghizadeh, Mohammad Taghi; Vatanparast, Morteza

2016-12-01

Zirconium dioxide (ZrO2) nanoparticles were fabricated successfully via ultrasonic-assisted method using ZrO(NO3)2·H2O, ethylenediamine and hydrazine as precursors in aqueous solution. Morphology, structure and composition of the obtained products were characterized by means of X-ray diffraction (XRD), scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDX), dynamic light scattering (DLS), Fourier transform infrared spectroscopy (FT-IR) and diffuse reflectance spectroscopy (DRS). Then, the synthesized nanoparticles were used to prepare Nafion/ZrO2 nanocomposite membranes. The properties of the membranes were studied by ion exchange capacity (IEC) proton conductivity (σ), thermal stability and water uptake measurements. The ex-situ Fenton's test was used to investigate the chemical stability of the membranes. From our results, compared with Nafion membrane, the nanocomposite membrane exhibited lower fluoride release and weight loss. Therefore, it can concluded that Nafion/ZrO2 nanocomposite exhibit more chemical stability than the pure Nafion membrane. ATR-FTIR spectra and SEM surface images of membranes also confirm these results. Copyright © 2016 Elsevier Inc. All rights reserved.

Adaptability and phenotypic stability of soybean cultivars for grain yield and oil content.

PubMed

Silva, K B; Bruzi, A T; Zuffo, A M; Zambiazzi, E V; Soares, I O; de Rezende, P M; Fronza, V; Vilela, G D L; Botelho, F B S; Teixeira, C M; de O Coelho, M A

2016-04-25

The aim of this study was to verify the adaptability and stability of soybean cultivars with regards to yield and oil content. Data of soybean yield and oil content were used from experiments set up in six environments in the 2011/12 and 2012/13 crop seasons in the municipalities of Patos de Minas, Uberaba, Lavras, and São Gotardo, Minas Gerais, Brazil, testing 36 commercial soybean cultivars of both conventional and transgenic varieties. The Wricke method and GGE biplot analysis were used to evaluate adaptability and stability of these cultivars. Large variations were observed in grain yield in relation to the different environments studied, showing that these materials are adaptable. The cultivars exhibited significant differences in oil content. The cultivars BRSGO204 (Goiânia) and BRSMG (Garantia) exhibited the greatest average grain yield in the different environments studied, and the cultivar BRSMG 760 SRR had the greatest oil content among the cultivars evaluated. Ecovalence was adopted to identify the most stable cultivars, and the estimates were nearly uniform both for grain yield and oil content, showing a variation of 0.07 and 0.01%, respectively. The GGE biplot was efficient at identifying cultivars with high adaptability and phenotype stability.

Spatially Developing Secondary Instabilities and Attachment Line Instability in Supersonic Boundary Layers

NASA Technical Reports Server (NTRS)

Li, Fei; Choudhari, Meelan M.

2008-01-01

This paper reports on progress towards developing a spatial stability code for compressible shear flows with two inhomogeneous directions, such as crossflow dominated swept-wing boundary layers and attachment line flows. Certain unique aspects of formulating a spatial, two-dimensional eigenvalue problem for the secondary instability of finite amplitude crossflow vortices are discussed. A primary test case used for parameter study corresponds to the low-speed, NLF-0415(b) airfoil configuration as tested in the ASU Unsteady Wind Tunnel, wherein a spanwise periodic array of roughness elements was placed near the leading edge in order to excite stationary crossflow modes with a specified fundamental wavelength. The two classes of flow conditions selected for this analysis include those for which the roughness array spacing corresponds to either the naturally dominant crossflow wavelength, or a subcritical wavelength that serves to reduce the growth of the naturally excited dominant crossflow modes. Numerical predictions are compared with the measured database, both as indirect validation for the spatial instability analysis and to provide a basis for comparison with a higher Reynolds number, supersonic swept-wing configuration. Application of the eigenvalue analysis to the supersonic configuration reveals that a broad spectrum of stationary crossflow modes can sustain sufficiently strong secondary instabilities as to potentially cause transition over this configuration. Implications of this finding for transition control in swept wing boundary layers are examined. Finally, extension of the spatial stability analysis to supersonic attachment line flows is also considered.

Stability-driven nonnegative matrix factorization to interpret spatial gene expression and build local gene networks.

PubMed

Wu, Siqi; Joseph, Antony; Hammonds, Ann S; Celniker, Susan E; Yu, Bin; Frise, Erwin

2016-04-19

Spatial gene expression patterns enable the detection of local covariability and are extremely useful for identifying local gene interactions during normal development. The abundance of spatial expression data in recent years has led to the modeling and analysis of regulatory networks. The inherent complexity of such data makes it a challenge to extract biological information. We developed staNMF, a method that combines a scalable implementation of nonnegative matrix factorization (NMF) with a new stability-driven model selection criterion. When applied to a set ofDrosophilaearly embryonic spatial gene expression images, one of the largest datasets of its kind, staNMF identified 21 principal patterns (PP). Providing a compact yet biologically interpretable representation ofDrosophilaexpression patterns, PP are comparable to a fate map generated experimentally by laser ablation and show exceptional promise as a data-driven alternative to manual annotations. Our analysis mapped genes to cell-fate programs and assigned putative biological roles to uncharacterized genes. Finally, we used the PP to generate local transcription factor regulatory networks. Spatially local correlation networks were constructed for six PP that span along the embryonic anterior-posterior axis. Using a two-tail 5% cutoff on correlation, we reproduced 10 of the 11 links in the well-studied gap gene network. The performance of PP with theDrosophiladata suggests that staNMF provides informative decompositions and constitutes a useful computational lens through which to extract biological insight from complex and often noisy gene expression data.

Synchrony, waves and ripple in spatially coupled Kuramoto oscillators with Mexican hat connectivity.

PubMed

Heitmann, Stewart; Ermentrout, G Bard

2015-06-01

Spatiotemporal waves of synchronized activity are known to arise in oscillatory neural networks with lateral inhibitory coupling. How such patterns respond to dynamic changes in coupling strength is largely unexplored. The present study uses analysis and simulation to investigate the evolution of wave patterns when the strength of lateral inhibition is varied dynamically. Neural synchronization was modeled by a spatial ring of Kuramoto oscillators with Mexican hat lateral coupling. Broad bands of coexisting stable wave solutions were observed at all levels of inhibition. The stability of these waves was formally analyzed in both the infinite ring and the finite ring. The broad range of multi-stability predicted hysteresis in transitions between neighboring wave solutions when inhibition is slowly varied. Numerical simulation confirmed the predicted transitions when inhibition was ramped down from a high initial value. However, non-wave solutions emerged from the uniform solution when inhibition was ramped upward from zero. These solutions correspond to spatially periodic deviations of phase that we call ripple states. Numerical continuation showed that stable ripple states emerge from synchrony via a supercritical pitchfork bifurcation. The normal form of this bifurcation was derived analytically, and its predictions compared against the numerical results. Ripple states were also found to bifurcate from wave solutions, but these were locally unstable. Simulation also confirmed the existence of hysteresis and ripple states in two spatial dimensions. Our findings show that spatial synchronization patterns can remain structurally stable despite substantial changes in network connectivity.

Influence of Pre-Training Predator Stress on the Expression of c-fos mRNA in the Hippocampus, Amygdala, and Striatum Following Long-Term Spatial Memory Retrieval

PubMed Central

VanElzakker, Michael B.; Zoladz, Phillip R.; Thompson, Vanessa M.; Park, Collin R.; Halonen, Joshua D.; Spencer, Robert L.; Diamond, David M.

2011-01-01

We have studied the influence of pre-training psychological stress on the expression of c-fos mRNA following long-term spatial memory retrieval. Rats were trained to learn the location of a hidden escape platform in the radial-arm water maze, and then their memory for the platform location was assessed 24 h later. Rat brains were extracted 30 min after the 24-h memory test trial for analysis of c-fos mRNA. Four groups were tested: (1) Rats given standard training (Standard); (2) Rats given cat exposure (Predator Stress) 30 min prior to training (Pre-Training Stress); (3) Rats given water exposure only (Water Yoked); and (4) Rats given no water exposure (Home Cage). The Standard trained group exhibited excellent 24 h memory which was accompanied by increased c-fos mRNA in the dorsal hippocampus and basolateral amygdala (BLA). The Water Yoked group exhibited no increase in c-fos mRNA in any brain region. Rats in the Pre-Training Stress group were classified into two subgroups: good and bad memory performers. Neither of the two Pre-Training Stress subgroups exhibited a significant change in c-fos mRNA expression in the dorsal hippocampus or BLA. Instead, stressed rats with good memory exhibited significantly greater c-fos mRNA expression in the dorsolateral striatum (DLS) compared to stressed rats with bad memory. This finding suggests that stressed rats with good memory used their DLS to generate a non-spatial (cue-based) strategy to learn and subsequently retrieve the memory of the platform location. Collectively, these findings provide evidence at a molecular level for the involvement of the hippocampus and BLA in the retrieval of spatial memory and contribute novel observations on the influence of pre-training stress in activating the DLS in response to long-term memory retrieval. PMID:21738501

Sintering, thermal stability and mechanical properties of ZrO2-WC composites obtained by pulsed electric current sintering

NASA Astrophysics Data System (ADS)

Huang, Shuigen; Vanmeensel, Kim; van der Biest, Omer; Vleugels, Jozef

2011-03-01

ZrO2-WC composites exhibit comparable mechanical properties as traditional WC-Co materials, which provides an opportunity to partially replace WC-Co for some applications. In this study, 2 mol.% Y2O3 stabilized ZrO2 composites with 40 vol.% WC were consolidated in the 1150°C-1850°C range under a pressure of 60 MPa by pulsed electric current sintering (PECS). The densification behavior, microstructure and phase constitution of the composites were investigated to clarify the role of the sintering temperature on the grain growth, mechanical properties and thermal stability of ZrO2 and WC components. Analysis results indicated that the composites sintered at 1350°C and 1450°C exhibited the highest tetragonal ZrO2 phase transformability, maximum toughness, and hardness and an optimal flexural strength. Chemical reaction of ZrO2 and C, originating from the graphite die, was detected in the composite PECS for 20 min at 1850°C in vacuum.

A Stable Plasmonic Cu@Cu2 O/ZnO Heterojunction for Enhanced Photocatalytic Hydrogen Generation.

PubMed

Lou, Yongbing; Zhang, Yake; Cheng, Lin; Chen, Jinxi; Zhao, Yixin

2018-05-09

The localized surface plasmon resonance (LSPR) effect has been widely utilized in photocatalysis, but most reported LSPR materials are based on noble metals of gold or silver with high chemical stability. Plasmonic copper nanoparticles that exhibit an LSPR absorbance at 600 nm are promising for many applications, such as photocatalysis. Unfortunately, plasmonic copper nanoparticles are affected by serious surface oxidation in air. Herein, a novel lollipop-shaped Cu@Cu 2 O/ZnO heterojunction nanostructure was designed, for the first time, to stabilize the plasmonic Cu core by decorating Cu@Cu 2 O core-shell structures with ZnO nanorods. This Cu@Cu 2 O/ZnO nanostructure exhibited significantly enhanced stability than that of regular Cu@Cu 2 O, which accounted for the remarkably enhanced photocatalytic H 2 evolution rate through water splitting, relative to pristine ZnO nanorods, over an extended wavelength range due to the plasmonic Cu core. © 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Fabrication and electro-optic characteristics of polymer-stabilized V-mode FLCD and intrinsic H-V-mode FLCD: their application to AM LCDs

NASA Astrophysics Data System (ADS)

Kobayashi, Shunsuke; Furuta, Hirokazu; Murakami, Yuji; Xu, Jun; Mochizuki, Akihiro

2003-04-01

Defect free polymer-stabilized (PS-)V-mode FLCDs and intrinsic half (H-)V-mode FLCDs have been fabricated; they exhibit high contrast ratio over 700:1 and high reliability for a temperature cycling test by using specially developed polyimide alignment materials, RN-1411 series, from Nissan Chem. Ind., and also by adopting special alignment technique such as appropriate rubbing technique, photoalignment, and ion beam irradiation techniques and also particularly developed polymer-stabilization technique. These FLCDs are shown to be useful for implementing a field sequential type full color (FS-FC) LCDs due to their fast response with the response time of τ = 100μs ~ 500μs that is 10 to 100 times faster that those of LCDs using NLCs. We have developed several prototype models of FS-FC LCDs having VGA specifications that exhibit good performance for displaying fast moving video rate images with wide color gamut.

Silver Nanoparticles Synthesized Using Caesalpinia sappan Extract as Potential Novel Nanoantibiotics Against Methicillin-Resistant Staphylococcus aureus.

PubMed

Jun, Sang Hui; Cha, Song-Hyun; Kim, Jae-Hyun; Yoon, Minho; Cho, Seonho; Park, Youmie

2015-08-01

Silver nanoparticles (AgNPs) have been shown to be effective antibacterial agents against methicillin-resistant Staphylococcus aureus (MRSA). In this study, AgNPs were synthesized using Caesalpinia sappan extract as a reducing agent to convert Ag+ to AgNPs. Seven stabilizers (surfactants and polymers) were added during the reduction step to increase the colloidal stability and to enhance the antibacterial activity of the AgNPs. Spherical and amorphous particles were primarily observed, with estimated diameters ranging from 30.2 to 47.5 nm. X-ray diffraction confirmed the face centered cubic structures of the AgNPs. Among the employed stabilizers, the cationic surfactant cetyltrimethylammonium bromide (CTAB) exhibited the highest antibacterial activity against 19 strains of MRSA, followed by polyvinylpyrrolidone (PVP, average molecular weight of 10,000). In contrast, the anionic surfactants sodium dodecyl sulfate (SDS) and sodium dodecylbenzene sulfonate (NaDDBS) did not exhibit any significant antibacterial activity, suggesting that the cationic surfactant head group contributed to the higher antibacterial activity of the AgNPs against MRSA.

Perturbation solutions of combustion instability problems

NASA Technical Reports Server (NTRS)

Googerdy, A.; Peddieson, J., Jr.; Ventrice, M.

1979-01-01

A method involving approximate modal analysis using the Galerkin method followed by an approximate solution of the resulting modal-amplitude equations by the two-variable perturbation method (method of multiple scales) is applied to two problems of pressure-sensitive nonlinear combustion instability in liquid-fuel rocket motors. One problem exhibits self-coupled instability while the other exhibits mode-coupled instability. In both cases it is possible to carry out the entire linear stability analysis and significant portions of the nonlinear stability analysis in closed form. In the problem of self-coupled instability the nonlinear stability boundary and approximate forms of the limit-cycle amplitudes and growth and decay rates are determined in closed form while the exact limit-cycle amplitudes and growth and decay rates are found numerically. In the problem of mode-coupled instability the limit-cycle amplitudes are found in closed form while the growth and decay rates are found numerically. The behavior of the solutions found by the perturbation method are in agreement with solutions obtained using complex numerical methods.

Wind-tunnel investigation of the flight characteristics of a canard general-aviation airplane configuration

NASA Technical Reports Server (NTRS)

Satran, D. R.

1986-01-01

A 0.36-scale model of a canard general-aviation airplane with a single pusher propeller and winglets was tested in the Langley 30- by 60-Foot Wind Tunnel to determine the static and dynamic stability and control and free-flight behavior of the configuration. Model variables made testing of the model possible with the canard in high and low positions, with increased winglet area, with outboard wing leading-edge droop, with fuselage-mounted vertical fin and rudder, with enlarged rudders, with dual deflecting rudders, and with ailerons mounted closer to the wing tips. The basic model exhibited generally good longitudinal and lateral stability and control characteristics. The removal of an outboard leading-edge droop degraded roll damping and produced lightly damped roll (wing rock) oscillations. In general, the model exhibited very stable dihedral effect but weak directional stability. Rudder and aileron control power were sufficiently adequate for control of most flight conditions, but appeared to be relatively weak for maneuvering compared with those of more conventionally configured models.

Assessing spatial coupling in complex population dynamics using mutual prediction and continuity statistics

USGS Publications Warehouse

Nichols, J.M.; Moniz, L.; Nichols, J.D.; Pecora, L.M.; Cooch, E.

2005-01-01

A number of important questions in ecology involve the possibility of interactions or ?coupling? among potential components of ecological systems. The basic question of whether two components are coupled (exhibit dynamical interdependence) is relevant to investigations of movement of animals over space, population regulation, food webs and trophic interactions, and is also useful in the design of monitoring programs. For example, in spatially extended systems, coupling among populations in different locations implies the existence of redundant information in the system and the possibility of exploiting this redundancy in the development of spatial sampling designs. One approach to the identification of coupling involves study of the purported mechanisms linking system components. Another approach is based on time series of two potential components of the same system and, in previous ecological work, has relied on linear cross-correlation analysis. Here we present two different attractor-based approaches, continuity and mutual prediction, for determining the degree to which two population time series (e.g., at different spatial locations) are coupled. Both approaches are demonstrated on a one-dimensional predator?prey model system exhibiting complex dynamics. Of particular interest is the spatial asymmetry introduced into the model as linearly declining resource for the prey over the domain of the spatial coordinate. Results from these approaches are then compared to the more standard cross-correlation analysis. In contrast to cross-correlation, both continuity and mutual prediction are clearly able to discern the asymmetry in the flow of information through this system.

Chiral mutagenesis of insulin. Contribution of the B20-B23 beta-turn to activity and stability.

PubMed

Nakagawa, Satoe H; Hua, Qing-xin; Hu, Shi-Quan; Jia, Wenhua; Wang, Shuhua; Katsoyannis, Panayotis G; Weiss, Michael A

2006-08-04

Insulin contains a beta-turn (residues B20-B23) interposed between two receptor-binding elements, the central alpha-helix of the B chain (B9-B19) and its C-terminal beta-strand (B24-B28). The turn contains conserved glycines at B20 and B23. Although insulin exhibits marked conformational variability among crystal forms, these glycines consistently maintain positive phi dihedral angles within a classic type-I beta-turn. Because the Ramachandran conformations of GlyB20 and GlyB23 are ordinarily forbidden to L-amino acids, turn architecture may contribute to structure or function. Here, we employ "chiral mutagenesis," comparison of corresponding D- and L-Ala substitutions, to investigate this turn. Control substitutions are introduced at GluB21, a neighboring residue exhibiting a conventional (negative) phi angle. The D- and L-Ala substitutions at B23 are associated with a marked stereospecific difference in activity. Whereas the D-AlaB23 analog retains native activity, the L analog exhibits a 20-fold decrease in receptor binding. By contrast, D- and L-AlaB20 analogs each exhibit high activity. Stereospecific differences between the thermodynamic stabilities of the analogs are nonetheless more pronounced at B20 (delta deltaG(u) 2.0 kcal/mole) than at B23 (delta deltaG(u) 0.7 kcal/mole). Control substitutions at B21 are well tolerated without significant stereospecificity. Chiral mutagenesis thus defines the complementary contributions of these conserved glycines to protein stability (GlyB20) or receptor recognition (GlyB23).

Roles of dispersal, stochasticity, and nonlinear dynamics in the spatial structuring of seasonal natural enemy-victim populations

Treesearch

Patrick C. Tobin; Ottar N. Bjornstad

2005-01-01

Natural enemy-victim systems may exhibit a range of dynamic space-time patterns. We used a theoretical framework to study spatiotemporal structuring in a transient natural enemy-victim system subject to differential rates of dispersal, stochastic forcing, and nonlinear dynamics. Highly mobile natural enemies that attacked less mobile victims were locally spatially...

Influence of late-life exposure to environmental enrichmentor exercise on hippocampal function and CA1 senescent physiology

PubMed Central

Kumar, A.; Rani, A.; Tchigranova, Olga; Lee, Wei-Hua; Foster, T.C.

2011-01-01

Aged (20–22 months) male Fischer 344 rats were randomly assigned to sedentary (A-SED), environmentally enriched (A-ENR) or exercise (A-EX) conditions. After 10–12 weeks of differential experience, the three groups of aged rats and young sedentary controls were tested for physical and cognitive function. Spatial discrimination learning and memory consolidation, tested on the water maze, were enhanced in A-ENR compared to A-SED. A-EX exhibited improved and impaired performance on the cue and spatial task, respectively. Impaired spatial learning in A-EX was likely due to a bias in response selection associated with exercise training, as object recognition memory improved for A-EX rats. An examination of senescent hippocampal physiology revealed that enrichment and exercise reversed age-related changes in long-term depression (LTD) and long-term potentiation (LTP). Rats in the enrichment group exhibited an increase in cell excitability compared to the other two groups of aged animals. The results indicate that differential experience biased the selection of a spatial or a response strategy and factors common across the two conditions, such as increased hippocampal activity associated with locomotion, contribute to reversal of senescent synaptic plasticity. PMID:21820213

A DOM Odyssey: The Tale of Molecular Transformations in an Aquifer near Bemidji, MN

NASA Astrophysics Data System (ADS)

Podgorski, D. C.; Zito, P.; Smith, D. F.; Cao, X.; Schmidt-Rohr, K.; Wagner, S.; Stubbins, A.; Aiken, G.; Cozzarelli, I.; Bekins, B. A.; Spencer, R. G.

2017-12-01

Analytical methods including fluorescence spectroscopy, NMR spectroscopy, and ultrahigh resolution mass spectrometry have significantly advanced the understanding of compositional controls on dissolved organic matter (DOM) processing and fate. Yet, we still heavily rely on extrapolation of chemical changes identified at the edges of the compositional continuum (i.e., endmembers) to assess DOM reactivity and stability. While extrapolation of chemical transformations is useful for determining relative changes in DOM composition, a comprehensive understanding of the underlying core structures and composition is required to develop advanced biogeochemical models. Studying DOM from natural systems is complicated by many variables associated with an open system including input from multiple sources, simultaneous photo-alteration and microbial processing, and obtaining samples that cover high spatial and temporal resolution. A 38-year biodegradation study at the National Crude Oil Spill Research site near Bemidji, MN provides a unique opportunity to monitor DOM in a relatively closed system. An extensively characterized 1 m thick oil body is confined to a 25 x 75 m2 area at the water table in the aquifer. Oxidized metabolites partition from the oil into the underlying aquifer increase the DOC concentration to > 100 ppm from < 2 ppm up-gradient from the oil body. This newly produced DOM is comprised of aliphatic compounds with high H/C, low O/C and blue-shifted fluorescence, similar in composition to permafrost- and algal-derived DOM. The aliphatic DOM is transported laterally from the oil pool by groundwater, creating a plume that ultimately discharges into the Unnamed Lake 325 m downgradient. More than 10 years later and hundreds of meters downgradient from the oil body, the DOC concentration has decreased to 3-5 ppm and the DOM is compositionally non-distinct. Microbes have left behind degradation products and selectively preserved compounds that exhibit red-shifted fluorescence and molecular formulas with O/C and H/C similar to those associated with the `island of stability'. Samples collected spatially from the DOM plume between these two endmembers provide sufficient temporal resolution to model both DOC concentration and DOM composition as a result of biodegradation.

Strongly nonlinear theory of rapid solidification near absolute stability

NASA Astrophysics Data System (ADS)

Kowal, Katarzyna N.; Altieri, Anthony L.; Davis, Stephen H.

2017-10-01

We investigate the nonlinear evolution of the morphological deformation of a solid-liquid interface of a binary melt under rapid solidification conditions near two absolute stability limits. The first of these involves the complete stabilization of the system to cellular instabilities as a result of large enough surface energy. We derive nonlinear evolution equations in several limits in this scenario and investigate the effect of interfacial disequilibrium on the nonlinear deformations that arise. In contrast to the morphological stability problem in equilibrium, in which only cellular instabilities appear and only one absolute stability boundary exists, in disequilibrium the system is prone to oscillatory instabilities and a second absolute stability boundary involving attachment kinetics arises. Large enough attachment kinetics stabilize the oscillatory instabilities. We derive a nonlinear evolution equation to describe the nonlinear development of the solid-liquid interface near this oscillatory absolute stability limit. We find that strong asymmetries develop with time. For uniform oscillations, the evolution equation for the interface reduces to the simple form f''+(βf')2+f =0 , where β is the disequilibrium parameter. Lastly, we investigate a distinguished limit near both absolute stability limits in which the system is prone to both cellular and oscillatory instabilities and derive a nonlinear evolution equation that captures the nonlinear deformations in this limit. Common to all these scenarios is the emergence of larger asymmetries in the resulting shapes of the solid-liquid interface with greater departures from equilibrium and larger morphological numbers. The disturbances additionally sharpen near the oscillatory absolute stability boundary, where the interface becomes deep-rooted. The oscillations are time-periodic only for small-enough initial amplitudes and their frequency depends on a single combination of physical parameters, including the morphological number, as well as the amplitude. The critical amplitude, at which solutions loose periodicity, depends on a single combination of parameters independent of the morphological number that indicate that non-periodic growth is most commonly present for moderate disequilibrium parameters. The spatial distribution of the interface develops deepening roots at late times. Similar spatial distributions are also seen in the limit in which both the cellular and oscillatory modes are close to absolute stability, and the roots deepen with larger departures from the two absolute stability boundaries.

Spontaneous assembly of chemically encoded two-dimensional coacervate droplet arrays by acoustic wave patterning

PubMed Central

Tian, Liangfei; Martin, Nicolas; Bassindale, Philip G.; Patil, Avinash J.; Li, Mei; Barnes, Adrian; Drinkwater, Bruce W.; Mann, Stephen

2016-01-01

The spontaneous assembly of chemically encoded, molecularly crowded, water-rich micro-droplets into periodic defect-free two-dimensional arrays is achieved in aqueous media by a combination of an acoustic standing wave pressure field and in situ complex coacervation. Acoustically mediated coalescence of primary droplets generates single-droplet per node micro-arrays that exhibit variable surface-attachment properties, spontaneously uptake dyes, enzymes and particles, and display spatial and time-dependent fluorescence outputs when exposed to a reactant diffusion gradient. In addition, coacervate droplet arrays exhibiting dynamical behaviour and exchange of matter are prepared by inhibiting coalescence to produce acoustically trapped lattices of droplet clusters that display fast and reversible changes in shape and spatial configuration in direct response to modulations in the acoustic frequencies and fields. Our results offer a novel route to the design and construction of ‘water-in-water' micro-droplet arrays with controllable spatial organization, programmable signalling pathways and higher order collective behaviour. PMID:27708286

Covalent bonding of antibodies of polystyrene latex beads: A concept

NASA Technical Reports Server (NTRS)

Tenoso, H. J.; Smith, D. G.

1972-01-01

Technique facilitates purification of vaccines and production of immunoadsorption columns exhibiting relatively long stability. Information interests biochemists, medical researchers, and pharmaceutical manufacturers.

The structure of the yeast plasma membrane SNARE complex reveals destabilizing water-filled cavities.

PubMed

Strop, Pavel; Kaiser, Stephen E; Vrljic, Marija; Brunger, Axel T

2008-01-11

SNARE proteins form a complex that leads to membrane fusion between vesicles, organelles, and plasma membrane in all eukaryotic cells. We report the 1.7A resolution structure of the SNARE complex that mediates exocytosis at the plasma membrane in the yeast Saccharomyces cerevisiae. Similar to its neuronal and endosomal homologues, the S. cerevisiae SNARE complex forms a parallel four-helix bundle in the center of which is an ionic layer. The S. cerevisiae SNARE complex exhibits increased helix bending near the ionic layer, contains water-filled cavities in the complex core, and exhibits reduced thermal stability relative to mammalian SNARE complexes. Mutagenesis experiments suggest that the water-filled cavities contribute to the lower stability of the S. cerevisiae complex.

Stability of Self-Referent Encoding Task performance and associations with change in depressive symptoms from early to middle childhood

PubMed Central

Goldstein, Brandon L.; Hayden, Elizabeth P.; Klein, Daniel N.

2014-01-01

Depressed individuals exhibit memory biases on the self-referent encoding task (SRET), such that those with depression exhibit poorer recall of positive, and enhanced recall of negative, trait adjectives (referred to as positive and negative processing biases). However, it is unclear when SRET biases emerge, whether they are stable, and if biases predict, or are predicted by, depressive symptoms. To address this, a community sample of 434 children completed the SRET and a depressive symptoms measure at ages 6 and 9. Negative and positive processing exhibited low, but significant, stability. At ages 6 and 9, depressive symptoms correlated with higher negative, and lower positive, SRET processing. Importantly, lower positive processing at age 6 predicted increased symptoms at age 9. However, negative processing at age 6 did not predict depressive symptoms at age 9, and depressive symptoms at age 6 did not predict SRET processing scores at age 9. This suggests that less positive processing may reflect vulnerability for future depressive symptoms. PMID:25530070

Citrobacter amalonaticus Phytase on the Cell Surface of Pichia pastoris Exhibits High pH Stability as a Promising Potential Feed Supplement

PubMed Central

Li, Cheng; Lin, Ying; Huang, Yuanyuan; Liu, Xiaoxiao; Liang, Shuli

2014-01-01

Phytase expressed and anchored on the cell surface of Pichia pastoris avoids the expensive and time-consuming steps of protein purification and separation. Furthermore, yeast cells with anchored phytase can be used as a whole-cell biocatalyst. In this study, the phytase gene of Citrobacter amalonaticus was fused with the Pichia pastoris glycosylphosphatidylinositol (GPI)-anchored glycoprotein homologue GCW61. Phytase exposed on the cell surface exhibits a high activity of 6413.5 U/g, with an optimal temperature of 60°C. In contrast to secreted phytase, which has an optimal pH of 5.0, phytase presented on the cell surface is characterized by an optimal pH of 3.0. Moreover, our data demonstrate that phytase anchored on the cell surface exhibits higher pH stability than its secreted counterpart. Interestingly, our in vitro digestion experiments demonstrate that phytase attached to the cell surface is a more efficient enzyme than secreted phytase. PMID:25490768

Citrobacter amalonaticus phytase on the cell surface of Pichia pastoris exhibits high pH stability as a promising potential feed supplement.

PubMed

Li, Cheng; Lin, Ying; Huang, Yuanyuan; Liu, Xiaoxiao; Liang, Shuli

2014-01-01

Phytase expressed and anchored on the cell surface of Pichia pastoris avoids the expensive and time-consuming steps of protein purification and separation. Furthermore, yeast cells with anchored phytase can be used as a whole-cell biocatalyst. In this study, the phytase gene of Citrobacter amalonaticus was fused with the Pichia pastoris glycosylphosphatidylinositol (GPI)-anchored glycoprotein homologue GCW61. Phytase exposed on the cell surface exhibits a high activity of 6413.5 U/g, with an optimal temperature of 60°C. In contrast to secreted phytase, which has an optimal pH of 5.0, phytase presented on the cell surface is characterized by an optimal pH of 3.0. Moreover, our data demonstrate that phytase anchored on the cell surface exhibits higher pH stability than its secreted counterpart. Interestingly, our in vitro digestion experiments demonstrate that phytase attached to the cell surface is a more efficient enzyme than secreted phytase.

Lipschitz stability for an inverse hyperbolic problem of determining two coefficients by a finite number of observations

NASA Astrophysics Data System (ADS)

Beilina, L.; Cristofol, M.; Li, S.; Yamamoto, M.

2018-01-01

We consider an inverse problem of reconstructing two spatially varying coefficients in an acoustic equation of hyperbolic type using interior data of solutions with suitable choices of initial condition. Using a Carleman estimate, we prove Lipschitz stability estimates which ensure unique reconstruction of both coefficients. Our theoretical results are justified by numerical studies on the reconstruction of two unknown coefficients using noisy backscattered data.

Soil internal drainage: temporal stability and spatial variability in succession bean-black oat

NASA Astrophysics Data System (ADS)

Salvador, M. M. S.; Libardi, P. L.; Moreira, N. B.; Sousa, H. H. F.; Neiverth, C. A.

2012-04-01

There are a variety of studies considering the soil water content, but those who consider the flow of water, which are translated by deep drainage and capillary rise are scarce, especially those who assess their spatio-temporal variability, due to its laborious obtaining. Large areas have been considered homogeneous, but show considerable spatial variability inherent in the soil, causing the appearance of zones of distinct physical properties. In deep, sandy soils where the groundwater level is far below the root zone of interference, internal drainage is one of the factors limiting the supply of water to the soil surface, and possibly one of the biggest factors that determines what kinds satisfactory development of plants present in a given landscape. The forms of relief may also be indicators of changes in soil properties, because this variability is caused by small changes that affect the slope of the pedogenetic processes and the transport and storage of water in the soil profile, i.e., the different trajectories of water flow in different forms of the landscape, is the cause of variability. The objectives of this research were: i) evaluate the spatial and temporal stability of internal soil water drainage in a place near and another distant from the root system in a bean-black-oat succession and ii) verify their spatial variability in relation to relief. With the hydraulic conductivity obtained by the instantaneous profile method and the total potential gradient obtained from the difference in readings of tensiometers installed at depths of 0.35 and 0.45 and 0.75 and 0.85 m in 60 sampling points totaling 1680 and 1200 observations during the cultivation of beans and oats, respectively, was obtained so the internal drainage / capillary rise through the Darcy-Buckingham equation. To evaluate the temporal stability the method used was the relative difference and Spearman correlation test and the spatial variability was analyzed as geostatistical methodology. During the period when the water flow in soil is higher, there is strong temporal stability in the depth of 0.40 m, which is the opposite for the periods of drying. The lowest relative difference and standard deviation for the internal drainage obtained during the cultivation of beans and depth of 0.40 m confirm the hypothesis that the research carried out during periods of soil water recharge have less variability than those in the drying period. Temporal stability was due to the topographic position of selected points, since the points chosen for the depth of 0.40 m in both growing seasons, are located on the lower portion of the relief, and the nominees for the depth of 0,80 m, the highest portion. There were differences in the spatial pattern of water flow in the soil along the crop succession, i.e. the seasonal demand for water by plants and evaporation from the soil at the time of drying, changed their distribution model with internal drainage phases and stages capillary rise.

Meta-ecosystem dynamics and functioning on finite spatial networks

PubMed Central

Marleau, Justin N.; Guichard, Frédéric; Loreau, Michel

2014-01-01

The addition of spatial structure to ecological concepts and theories has spurred integration between sub-disciplines within ecology, including community and ecosystem ecology. However, the complexity of spatial models limits their implementation to idealized, regular landscapes. We present a model meta-ecosystem with finite and irregular spatial structure consisting of local nutrient–autotrophs–herbivores ecosystems connected through spatial flows of materials and organisms. We study the effect of spatial flows on stability and ecosystem functions, and provide simple metrics of connectivity that can predict these effects. Our results show that high rates of nutrient and herbivore movement can destabilize local ecosystem dynamics, leading to spatially heterogeneous equilibria or oscillations across the meta-ecosystem, with generally increased meta-ecosystem primary and secondary production. However, the onset and the spatial scale of these emergent dynamics depend heavily on the spatial structure of the meta-ecosystem and on the relative movement rate of the autotrophs. We show how this strong dependence on finite spatial structure eludes commonly used metrics of connectivity, but can be predicted by the eigenvalues and eigenvectors of the connectivity matrix that describe the spatial structure and scale. Our study indicates the need to consider finite-size ecosystems in meta-ecosystem theory. PMID:24403323

Effect of confinement potential on exciton diamagnetism in the perspective of constituent carriers in a Quantum Well

NASA Astrophysics Data System (ADS)

Vignesh, G.; Nithiananthi, P.

2018-03-01

Diamagnetic susceptibility of excitons is investigated in the perspective of the electron and hole separation along the lateral (ρ) and normal direction (z) of a GaAs/AlxGa1-xAs quantum well. Using a variational technique, the spatial extensions of these carriers has been observed. The coulomb interaction of the carriers is investigated by subjecting the carriers to three confinement potentials, Square (SQW), Parabolic (PQW) and Triangular Quantum Wells (TQW). The stability of the exciton has been estimated by observing the diamagnetic susceptibility. The hole is very sensitive to confinement potential and has tremendous variations in spatial extension. Among the three confinements, TQW offers more localization and high stability to excitons. The anisotropy of band parameters and the dielectric constants of the well and barrier materials are taken into consideration.

Inviscid spatial stability of a compressible mixing layer. II - The flame sheet model

NASA Technical Reports Server (NTRS)

Jackson, T. L.; Grosch, C. E.

1990-01-01

The results of an inviscid spatial calculation for a compressible reacting mixing layer are reported. The limit of infinitive activation energy is taken and the diffusion flame is approximated by a flame sheet. Results are reported for the phase speeds of the neutral waves and maximum growth rates of the unstable waves as a function of the parameters of the problem: the ratio of the temperature of the stationary stream to that of the moving stream, the Mach number of the moving streams, the heat release per unit mass fraction of the reactant, the equivalence ratio of the reaction, and the frequency of the disturbance. These results are compared to the phase speeds and growth rates of the corresponding nonreacting mixing layer. We show that the addition of combustion has important and complex effects on the flow stability.

How Many Grid Points are Required for Time Accurate Simulations Scheme Selection and Scale-Discriminant Stabilization

DTIC Science & Technology

2015-11-24

spatial concerns: ¤ how well are gradients captured? (resolution requirement) spatial/temporal concerns: ¤ dispersion and dissipation error...distribution is unlimited. Gradient Capture vs. Resolution: Single Mode FFT: Solution/Derivative: Convergence: f x( )= sin(x) with x∈[0,2π ] df dx...distribution is unlimited. Gradient Capture vs. Resolution: 
 Multiple Modes FFT: Solution/Derivative: Convergence: 6 __ CD02 __ CD04 __ CD06

Photonic Lantern Adaptive Spatial Mode Control in LMA Fiber Amplifiers using SPGD

DTIC Science & Technology

2015-12-15

ll.mit.edu Abstract: We demonstrate adaptive-spatial mode control (ASMC) in few- moded double- clad large mode area (LMA) fiber amplifiers by using an...combination resulting in a single fundamental mode at the output is achieved. 2015 Optical Society of America OCIS codes: (140.3510) Lasers ...fiber; (140.3425) Laser stabilization; (060.2340) Fiber optics components; (110.1080) Active or adaptive optics; References and links 1. C

Early development of spatial-numeric associations: evidence from spatial and quantitative performance of preschoolers.

PubMed

Opfer, John E; Thompson, Clarissa A; Furlong, Ellen E

2010-09-01

Numeric magnitudes often bias adults' spatial performance. Partly because the direction of this bias (left-to-right versus right-to-left) is culture-specific, it has been assumed that the orientation of spatial-numeric associations is a late development, tied to reading practice or schooling. Challenging this assumption, we found that preschoolers expected numbers to be ordered from left-to-right when they searched for objects in numbered containers, when they counted, and (to a lesser extent) when they added and subtracted. Further, preschoolers who lacked these biases demonstrated more immature, logarithmic representations of numeric value than preschoolers who exhibited the directional bias, suggesting that spatial-numeric associations aid magnitude representations for symbols denoting increasingly large numbers.