Statistical modeling of the long-range-dependent structure of barrier island framework geology and surface geomorphology

NASA Astrophysics Data System (ADS)

Weymer, Bradley A.; Wernette, Phillipe; Everett, Mark E.; Houser, Chris

2018-06-01

Shorelines exhibit long-range dependence (LRD) and have been shown in some environments to be described in the wave number domain by a power-law characteristic of scale independence. Recent evidence suggests that the geomorphology of barrier islands can, however, exhibit scale dependence as a result of systematic variations in the underlying framework geology. The LRD of framework geology, which influences island geomorphology and its response to storms and sea level rise, has not been previously examined. Electromagnetic induction (EMI) surveys conducted along Padre Island National Seashore (PAIS), Texas, United States, reveal that the EMI apparent conductivity (σa) signal and, by inference, the framework geology exhibits LRD at scales of up to 101 to 102 km. Our study demonstrates the utility of describing EMI σa and lidar spatial series by a fractional autoregressive integrated moving average (ARIMA) process that specifically models LRD. This method offers a robust and compact way of quantifying the geological variations along a barrier island shoreline using three statistical parameters (p, d, q). We discuss how ARIMA models that use a single parameter d provide a quantitative measure for determining free and forced barrier island evolutionary behavior across different scales. Statistical analyses at regional, intermediate, and local scales suggest that the geologic framework within an area of paleo-channels exhibits a first-order control on dune height. The exchange of sediment amongst nearshore, beach, and dune in areas outside this region are scale independent, implying that barrier islands like PAIS exhibit a combination of free and forced behaviors that affect the response of the island to sea level rise.

Variation across mitochondrial gene trees provides evidence for systematic error: How much gene tree variation is biological?

PubMed

Richards, Emilie J; Brown, Jeremy M; Barley, Anthony J; Chong, Rebecca A; Thomson, Robert C

2018-02-19

The use of large genomic datasets in phylogenetics has highlighted extensive topological variation across genes. Much of this discordance is assumed to result from biological processes. However, variation among gene trees can also be a consequence of systematic error driven by poor model fit, and the relative importance of biological versus methodological factors in explaining gene tree variation is a major unresolved question. Using mitochondrial genomes to control for biological causes of gene tree variation, we estimate the extent of gene tree discordance driven by systematic error and employ posterior prediction to highlight the role of model fit in producing this discordance. We find that the amount of discordance among mitochondrial gene trees is similar to the amount of discordance found in other studies that assume only biological causes of variation. This similarity suggests that the role of systematic error in generating gene tree variation is underappreciated and critical evaluation of fit between assumed models and the data used for inference is important for the resolution of unresolved phylogenetic questions.

Shape Variation in Aterian Tanged Tools and the Origins of Projectile Technology: A Morphometric Perspective on Stone Tool Function

PubMed Central

Iovita, Radu

2011-01-01

Background Recent findings suggest that the North African Middle Stone Age technocomplex known as the Aterian is both much older than previously assumed, and certainly associated with fossils exhibiting anatomically modern human morphology and behavior. The Aterian is defined by the presence of ‘tanged’ or ‘stemmed’ tools, which have been widely assumed to be among the earliest projectile weapon tips. The present study systematically investigates morphological variation in a large sample of Aterian tools to test the hypothesis that these tools were hafted and/or used as projectile weapons. Methodology/Principal Findings Both classical morphometrics and Elliptical Fourier Analysis of tool outlines are used to show that the shape variation in the sample exhibits size-dependent patterns consistent with a reduction of the tools from the tip down, with the tang remaining intact. Additionally, the process of reduction led to increasing side-to-side asymmetries as the tools got smaller. Finally, a comparison of shape-change trajectories between Aterian tools and Late Paleolithic arrowheads from the North German site of Stellmoor reveal significant differences in terms of the amount and location of the variation. Conclusions/Significance The patterns of size-dependent shape variation strongly support the functional hypothesis of Aterian tools as hafted knives or scrapers with alternating active edges, rather than as weapon tips. Nevertheless, the same morphological patterns are interpreted as one of the earliest evidences for a hafting modification, and for the successful combination of different raw materials (haft and stone tip) into one implement, in itself an important achievement in the evolution of hominin technologies. PMID:22216161

Death of a back-arc magmatic system: Temporal variations of melt-stagnation in peridotites from the Godzilla Megamullion

NASA Astrophysics Data System (ADS)

Loocke, M.; Snow, J. E.; Ohara, Y.

2011-12-01

Sampling of the Godzilla Megamullion (GM) Oceanic Core Complex located on the extinct Parece Vela Rift within the Philippine Sea has returned a dominantly ultramafic lithology comprised of distinct petrographically depleted, fertile, and melt-percolated groups of samples (1). Petrographic observations of the ultramafic rocks from GM coupled with major element geochemistry of spinels have exhibited systematic, temporal trends in the degree of melt-stagnation along the length of the OCC (2,3,4,5). Notable trends in the percentage of peridotite samples containing evidence of plagioclase impregnation as well as trends in spinel Cr# (Cr / Cr + Al), Mg# (Mg / Mg + Fe), and TiO2 are exhibited along the length of the structure. The distal portion of the mullion (the region closest to the breakaway) exhibits characteristics attributed to normal mid-ocean ridge spreading. The percentage of plagioclase impregnation is ˜25% (7 out of 28 samples), which compares to the roughly 20% average for abyssal peridotites (6). The average Cr# is 0.35 with variation from 0.3 to 0.6 in melt-reacted samples and the TiO2 follows suit with values lower than 0.12 wt. % with the exception of 1.6 wt. % for a single reacted sample. The Medial region exhibits a decrease in plagioclase percentage to 12% (2 out of 17 samples) and fertile Cr#s as low as 0.12 with low TiO2 (values <0.1 wt. %). The proximal region (the region closest to the termination of spreading) exhibits a large increase in the degree of plagioclase impregnation to 53% (62 out of 116 samples). Cr#s in the proximal region range from very fertile (0.12) to depleted (0.65) with an overall increase in the variation and maximum TiO2 content (0 to 0.8 wt. %). These length scale variations are interpreted to indicate a change in overall character for the magmatic system of the GM ridge segment with time. The distal region may represent a robust mantle section related to normal mid-oceanic ridge spreading that rapidly gives way to the fertile medial region. The medial region may then represent a portion of mantle rock which was present in the zone of melting beneath the ridge during the formation of the breakaway. The proximal region exhibits a large increase in melt-stagnation which can be attributed to the runaway process of entrapment of transient melt within the thickening lithosphere beneath the ridge. (1) Ohara, et al., (2003) G3. 4 (7), 8611, 10.1029/2002GC000469. (2) Ohara, et al., (2009), Eos Trans. AGU, 90(52), Fall Meet. Suppl. Abst.Num. T33D-06 (3) Loocke, et al., (2009), Eos Trans. AGU, 90(52), Fall Meet. Suppl. Abst.Num. T21A-1776 (4) Snow, et al., (2009), Eos Trans. AGU, 90(52), Fall Meet. Suppl. Abst.Num. T33D-07 (5)Loocke, M., Snow, J.E., and Ohara, Y. (2010), Systematics of melt stagnation in peridotites from the Godzilla Megamullion, Abstract T23A-2227 presented at 2010 Fall Meeting, AGU, San Francisco, Calif., 13-17 Dec. (6) Dick (1989) Geol Soc. Lond. Spec. Pub. 42:71-105.

Cellular Interrogation: Exploiting Cell-to-Cell Variability to Discriminate Regulatory Mechanisms in Oscillatory Signalling.

PubMed

Estrada, Javier; Andrew, Natalie; Gibson, Daniel; Chang, Frederick; Gnad, Florian; Gunawardena, Jeremy

2016-07-01

The molecular complexity within a cell may be seen as an evolutionary response to the external complexity of the cell's environment. This suggests that the external environment may be harnessed to interrogate the cell's internal molecular architecture. Cells, however, are not only nonlinear and non-stationary, but also exhibit heterogeneous responses within a clonal, isogenic population. In effect, each cell undertakes its own experiment. Here, we develop a method of cellular interrogation using programmable microfluidic devices which exploits the additional information present in cell-to-cell variation, without requiring model parameters to be fitted to data. We focussed on Ca2+ signalling in response to hormone stimulation, which exhibits oscillatory spiking in many cell types and chose eight models of Ca2+ signalling networks which exhibit similar behaviour in simulation. We developed a nonlinear frequency analysis for non-stationary responses, which could classify models into groups under parameter variation, but found that this question alone was unable to distinguish critical feedback loops. We further developed a nonlinear amplitude analysis and found that the combination of both questions ruled out six of the models as inconsistent with the experimentally-observed dynamics and heterogeneity. The two models that survived the double interrogation were mathematically different but schematically identical and yielded the same unexpected predictions that we confirmed experimentally. Further analysis showed that subtle mathematical details can markedly influence non-stationary responses under parameter variation, emphasising the difficulty of finding a "correct" model. By developing questions for the pathway being studied, and designing more versatile microfluidics, cellular interrogation holds promise as a systematic strategy that can complement direct intervention by genetics or pharmacology.

Solar Cycle Effects on Equatorial Electrojet Strength and Low Latitude Ionospheric Variability (P10)

NASA Astrophysics Data System (ADS)

Veenadhari, B.; Alex, S.

2006-11-01

veena_iig@yahoo.co.in The most obvious indicators of the activity of a solar cycle are sunspots, flares, plages, and soon. These are intimately linked to the solar magnetic fields, heliospheric processes which exhibit complex but systematic variations. The changes in geomagnetic activity, as observed in the ground magnetic records follow systematic correspondence with the solar activity conditions. Thus the transient variations in the magnetic field get modified by differing solar conditions. Also the solar cycle influences the Earth causing changes in geomagnetic activity, the magnetosphere and the ionosphere. Daily variations in the ground magnetic field are produced by different current systems in the earth’s space environment flowing in the ionosphere and magnetosphere which has a strong dependence on latitude and longitude of the location. The north-south (Horizontal) configuration of the earth’s magnetic field over the equator is responsible for the narrow band of current system over the equatorial latitudes and is called the Equatorial electrojet (EEJ) and is a primary driver for Equatorial Ionization anomaly (EIA). Equatorial electric fields and plasma drifts play the fundamental roles on the morphology of the low latitude ionosphere and strongly vary during geomagnetically quiet and disturbed periods. Quantitative study is done to illustrate the development process of EEJ and its influence on ionospheric parameters. An attempt is also made to examine and discuss the response of the equatorial electrojet parameters to the fast varying conditions of solar wind and interplanetary parameters.

Modeling Systematicity and Individuality in Nonlinear Second Language Development: The Case of English Grammatical Morphemes

ERIC Educational Resources Information Center

Murakami, Akira

2016-01-01

This article introduces two sophisticated statistical modeling techniques that allow researchers to analyze systematicity, individual variation, and nonlinearity in second language (L2) development. Generalized linear mixed-effects models can be used to quantify individual variation and examine systematic effects simultaneously, and generalized…

Inelastic X-ray Scattering Studies of Plasmons in Carbon Nanotubes

NASA Astrophysics Data System (ADS)

Upton, M. H.; Casa, D.; Gog, T.; Misewich, J.; Hill, J. P.; Lowndes, D.; Eres, G.

2006-03-01

We report preliminary inelastic x-ray scattering measurements of the plasmon dispersions in oriented multi- and single- walled carbon nanotubes (M- and S- WCNT) and compare them to the plasmon dispersion in graphite. Two plasmon bands are observed dispersing along the nanotubes' axes: the π and π+σ plasmon bands. The π+σ plasmon band exhibits an apparent systematic variation in energy. Specifically, it has a lower energy in MWCNT than in graphite, and a still lower energy in SWCNT. The energy of the π+σ plasmon band is determined by the plasma frequency of the material, which is proportional to the square root of the electron density. We postulate that the energy shift is a result of a surface effect -- the electron wave function extends past the surface, lowering the average electron density in the bulk. The higher surface-to-volume ratio of the mostly SW sample would then lower the plasmon frequency with respect to the MWCNT sample and graphite. Thus, the systematic variation in plasmon frequency may be explained by a lowering of the net electron density by the surfaces in S- and M-WCNT. Work performed at BNL and the Advanced Photon Source was supported by the US DOE under contracts No. DE-AC02-98CH10886 and No. W-31-109-Eng-38 respectively.

Decision-case mix model for analyzing variation in cesarean rates.

PubMed

Eldenburg, L; Waller, W S

2001-01-01

This article contributes a decision-case mix model for analyzing variation in c-section rates. Like recent contributions to the literature, the model systematically takes into account the effect of case mix. Going beyond past research, the model highlights differences in physician decision making in response to obstetric factors. Distinguishing the effects of physician decision making and case mix is important in understanding why c-section rates vary and in developing programs to effect change in physician behavior. The model was applied to a sample of deliveries at a hospital where physicians exhibited considerable variation in their c-section rates. Comparing groups with a low versus high rate, the authors' general conclusion is that the difference in physician decision tendencies (to perform a c-section), in response to specific obstetric factors, is at least as important as case mix in explaining variation in c-section rates. The exact effects of decision making versus case mix depend on how the model application defines the obstetric condition of interest and on the weighting of deliveries by their estimated "risk of Cesarean." The general conclusion is supported by an additional analysis that uses the model's elements to predict individual physicians' annual c-section rates.

BET surface area distributions in polar stream sediments: Implications for silicate weathering in a cold-arid environment

USGS Publications Warehouse

Marra, Kristen R.; Elwood Madden, Megan E; Soreghan, Gerilyn S.; Hall, Brenda L

2014-01-01

BET surface area values are critical for quantifying the amount of potentially reactive sediments available for chemical weathering and ultimately, prediction of silicate weathering fluxes. BET surface area values of fine-grained (<62.5 μm) sediment from the hyporheic zone of polar glacial streams in the McMurdo Dry Valleys, Antarctica (Wright and Taylor Valleys) exhibit a wide range (2.5–70.6 m2/g) of surface area values. Samples from one (Delta Stream, Taylor Valley) of the four sampled stream transects exhibit high values (up to 70.6 m2/g), which greatly exceed surface area values from three temperate proglacial streams (0.3–12.1 m2/g). Only Clark stream in Wright Valley exhibits a robust trend with distance, wherein surface area systematically decreases (and particle size increases) in the mud fraction downstream, interpreted to reflect rapid dissolution processes in the weathering environment. The remaining transects exhibit a range in variability in surface area distributions along the length of the channel, likely related to variations in eolian input to exposed channel beds, adjacent snow drifts, and to glacier surfaces, where dust is trapped and subsequently liberated during summer melting. Additionally, variations in stream discharge rate, which mobilizes sediment in pulses and influences water:rock ratios, the origin and nature of the underlying drift material, and the contribution of organic acids may play significant roles in the production and mobilization of high-surface area sediment. This study highlights the presence of sediments with high surface area in cold-based glacier systems, which influences models of chemical denudation rates and the impact of glacial systems on the global carbon cycle.

Sources of variation and genetic profile of spontaneous, out-of-season ovulatory activity in the Chios sheep

PubMed Central

Avdi, Melpomeni; Banos, Georgios; Kouttos, Athanasios; Bodin, Loys; Chemineau, Philippe

2003-01-01

Organising the breeding plan of a seasonally breeding species, such as sheep, presents a challenge to farmers and the industry as a whole, since both economical and biological considerations need to be carefully balanced. Understanding the breeding activity of individual animals becomes a prerequisite for a successful breeding program. This study set out to investigate the sources of variation and the genetic profile of the spontaneous, out-of-season ovulatory activity of ewes of the Chios dairy sheep breed in Greece. The definition of the trait was based on blood progesterone levels, measured before exposing the ewes to rams, which marks the onset of the usual breeding season. Data were 707 records, taken over two consecutive years, of 435 ewes kept at the Agricultural Research Station of Chalkidiki in northern Greece. When all available pedigree was included, the total number of animals involved was 1068. On average, 29% of all ewes exhibited spontaneous, out-of-season ovulatory activity, with no substantial variation between the years. Significant sources of systematic variation were the ewe age and live weight, and the month of previous lambing. Older, heavier ewes, that had lambed early the previous autumn, exhibited more frequent activity. Heritability estimates were 0.216 (± 0.084) with a linear and 0.291 with a threshold model. The latter better accounts for the categorical nature of the trait. The linear model repeatability was 0.230 (± 0.095). The results obtained in this study support the notion that spontaneous out-of-season ovulatory activity can be considered in the development of a breeding plan for the Chios sheep breed. PMID:12605851

Effects of climate on chemical weathering in watersheds

USGS Publications Warehouse

White, A.F.; Blum, A.E.

1995-01-01

Climatic effects on chemical weathering are evaluated by correlating variations in solute concentrations and fluxes with temperature, precipitation, runoff, and evapotranspiration (ET) for a worldwide distribution of sixty-eight watersheds underlain by granitoid rock types. Stream solute concentrations are strongly correlated with proportional ET loss, and evaporative concentration makes stream solute concentrations an inapprorpiate surrogate for chemical weathering. Chemical fluxes are unaffected by ET, and SiO2 and Na weathering fluxes exhibit systematic increases with precipitation, runoff, and temperature. However, warm and wet watersheds produce anomalously rapid weathering rates. A proposed model that provides an improved prediction of weathering rates over climatic extremes is the product of linear precipitation and Arrhenius temperature functions. The resulting apparent activation energies based on SiO2 and Na fluxes are 59.4 and 62.5 kJ.mol-1, respectively. The coupling between temperature and precipitation emphasizes the importance of tropical regions in global silicate weathering fluxes, and suggests it is not representative to use continental averages for temperature and precipitation in the weathering rate functions of global carbon cycling and climatic change models. Fluxes of K, Ca, and Mg exhibit no climatic correlation, implying that other processes, such as ion exchange, nutrient cycling, and variations in lithology, obscure any climatic signal. -from Authors

Remote compositional analysis of lunar olivine-rich lithologies with Moon Mineralogy Mapper (M3) spectra

USGS Publications Warehouse

Isaacson, P.J.; Pieters, C.M.; Besse, S.; Clark, R.N.; Head, J.W.; Klima, R.L.; Mustard, J.F.; Petro, N.E.; Staid, M.I.; Sunshine, J.M.; Taylor, L.A.; Thaisen, K.G.; Tompkins, S.

2011-01-01

A systematic approach for deconvolving remotely sensed lunar olivine-rich visible to near-infrared (VNIR) reflectance spectra with the Modified Gaussian Model (MGM) is evaluated with Chandrayaan-1 Moon Mineralogy Mapper (M 3) spectra. Whereas earlier studies of laboratory reflectance spectra focused only on complications due to chromite inclusions in lunar olivines, we develop a systematic approach for addressing (through continuum removal) the prominent continuum slopes common to remotely sensed reflectance spectra of planetary surfaces. We have validated our continuum removal on a suite of laboratory reflectance spectra. Suites of olivine-dominated reflectance spectra from a small crater near Mare Moscoviense, the Copernicus central peak, Aristarchus, and the crater Marius in the Marius Hills were analyzed. Spectral diversity was detected in visual evaluation of the spectra and was quantified using the MGM. The MGM-derived band positions are used to estimate the olivine's composition in a relative sense. Spectra of olivines from Moscoviense exhibit diversity in their absorption features, and this diversity suggests some variation in olivine Fe/Mg content. Olivines from Copernicus are observed to be spectrally homogeneous and thus are predicted to be more compositionally homogeneous than those at Moscoviense but are of broadly similar composition to the Moscoviense olivines. Olivines from Aristarchus and Marius exhibit clear spectral differences from those at Moscoviense and Copernicus but also exhibit features that suggest contributions from other phases. If the various precautions discussed here are weighed carefully, the methods presented here can be used to make general predictions of absolute olivine composition (Fe/Mg content). Copyright ?? 2011 by the American Geophysical Union.

Monsoon climate response in Indian teak (Tectona grandis L.f.) along a transect from coast to inland

NASA Astrophysics Data System (ADS)

Sengupta, Saikat; Borgaonkar, Hemant; Joy, Reji Mariya; Ram, Somaru

2017-11-01

Indian monsoon (June-September) and post monsoon (October-November) rainfall show a distinct trend from coast to inland primarily due to moisture availability. However, the response of this synoptic-scale variation of rainfall amount to annual ring growth of Indian teak has not been studied systematically yet. The study is important as (1) ring width of Indian teak is considered as a reliable proxy for studying monsoon climate variability in multi-centennial time scale and (2) observed meteorological data show systematic changes in rainfall variation from coast to inland since last three decades. Towards this, we present here tree-ring width data from two locations—Thatibanda (1747-1979) and Nagzira (1728-2000) and use similar published data from two other locations—Allapalli (1866-1897) and Edugurapalli (1827-2000). The locations fall along a southeast northwest transect from south east Indian coast to inland. Monthly mean data from nearest observatories show an increasing trend in monsoon rainfall and a pronounced decreasing trend in post monsoon rainfall towards inland. Ring width data show moderately positive response to monsoon rainfall and negative response to summer (March-May) temperature for all stations suggesting moisture deficit in hot summer and intense precipitation in monsoon affect ring growth pattern in different ways. Ring width indices also exhibit significantly positive response with post monsoon rainfall at coastal location. The response gradually reduces towards inland. This preliminary study, thus, suggests that Indian teak has a potential to capture signals of the synoptic variation of post monsoon rainfall from coast to inland.

Jovian dust streams: A monitor of Io's volcanic plume activity

USGS Publications Warehouse

Kruger, H.; Geissler, P.; Horanyi, M.; Graps, A.L.; Kempf, S.; Srama, R.; Moragas-Klostermeyer, G.; Moissl, R.; Johnson, T.V.; Grun, E.

2003-01-01

Streams of high speed dust particles originate from Jupiter's moon Io. After release from Io, the particles collect electric charges in the Io plasma torus, gain energy from the co-rotating electric field of Jupiter's magnetosphere, and leave the Jovian system into interplanetary space with escape speeds over 200 km s-1. The Galileo spacecraft has continuously monitored the dust streams during 34 revolutions about Jupiter between 1996 and 2002. The observed dust fluxes exhibit large orbit-to-orbit variability due to systematic and stochastic changes. After removal of the systematic variations, the total dust emission rate of Io has been calculated. It varies between 10-3 and 10 kg s-1, and is typically in the range of 0.1 to 1 kg s-1. We compare the dust emission rate with other markers of volcanic activity on Io like large-area surface changes caused by volcanic deposits and sightings of volcanic plumes. Copyright 2003 by the American Geophysical Union.

Synthesis and ferroelectric properties of La-substituted PZFNT

NASA Astrophysics Data System (ADS)

Singh, Pratibha; Singh, Sangeeta; Juneja, J. K.; Prakash, Chandra; Raina, K. K.; Kumar, Vinod; Pant, R. P.

2010-01-01

In this paper we are reporting a systematic study on ferroelectric properties of lanthanum (La) substituted modified lead zirconate titanate (PLZFNT) ceramics which were fabricated by mixed oxide process. La contents were varied in between 0 and 0.01 in steps of 0.0025. The X-ray diffraction study shows single phase for all samples. Silver electrode was deposited on flat surfaces of sintered discs for P-E (polarization vs. electric field) measurements. All compositions exhibited well-defined ferroelectric behavior at room temperature. Hysteresis loops were also recorded at different temperatures for all the compositions which showed typical variation of ferroelectric nature. The PLZFNT composition with 1 mol% of La showed the best retention behavior. The results are discussed.

Oxygen isotopic composition and U-Pb discordance in zircon

USGS Publications Warehouse

Booth, A.L.; Kolodny, Y.; Chamberlain, C.P.; McWilliams, M.; Schmitt, A.K.; Wooden, J.

2005-01-01

We have investigated U-Pb discordance and oxygen isotopic composition of zircon using high-spatial resolution ??18O measurement by ion microprobe. ??18O in both concordant and discordant zircon grains provides an indication of the relationship between fluid interaction and discordance. Our results suggest that three characteristics of zircon are interrelated: (1) U-Pb systematics and concomitant age discordance, (2) ??18O and the water-rock interactions implied therein, and (3) zircon texture, as revealed by cathodoluminescence and BSE imaging. A key observation is that U-Pb-disturbed zircons are often also variably depleted in 18O, but the relationship between discordance and ??18O is not systematic. ??18O values of discordant zircons are generally lighter but irregular in their distribution. Textural differences between zircon grains can be correlated with both U-Pb discordance and ??18O. Discordant grains exhibit either a recrystallized, fractured, or strongly zoned CL texture, and are characteristic of 18O depletion. We interpret this to be a result of metamictization, leading to destruction of the zircon lattice and an increased susceptibility to lead loss. Conversely, grains that are concordant have less-expressed zoning and a smoother CL texture and are enriched in 18O. From this it is apparent that various stages of water-rock interaction, as evidenced by systematic variations in ??18O, leave their imprint on both the texture and U-Pb systematics of zircon. Copyright ?? 2005 Elsevier Ltd.

Iron Isotope Systematics of the Bushveld Complex, South Africa: Initial Results

NASA Astrophysics Data System (ADS)

Stausberg, N.; Lesher, C. E.; Hoffmann-Barfod, G.; Glessner, J. J.; Tegner, C.

2014-12-01

Iron isotopes show systematic changes in igneous rocks that have been ascribed to fractional crystallization, partial melting, as well as, diffusion effects. Layered mafic intrusions, such as the Paleoproterozoic Bushveld Igneous Complex, are ideally suited to investigate stable isotope fractionation arising principally by fractional crystallization. The upper 2.1km of the Bushveld Complex (Upper and Upper Main Zone, UUMZ) crystallized from a basaltic magma produced by a major recharge event, building up a sequence of tholeiitic, Fe-rich, gabbroic cumulate rocks that display systematic variations in mineralogy and mineral compositions consistent with fractional crystallization. Within this sequence, magnetite joins the liquidus assemblage at ˜260m, followed by olivine at 460m and apatite at 1000m. Here, we present iron isotope measurements of bulk cumulate rocks from the Bierkraal drill core of UUMZ of the western limb. Iron was chemically separated from its matrix and analyzed for δ56Fe (relative to IRMM- 014) with a Nu plasma MC-ICPMS at the University of California, Davis, using (pseudo-) high resolution and sample-standard bracketing. The δ56Fe values for Bushveld cumulates span a range from 0.04‰ to 0.36‰, and systematically correlate with the relative abundance of pyroxene + olivine, magnetite and plagioclase. Notably, the highest δ56Fe values are found in plagioclase-rich cumulates that formed prior to magnetite crystallization. δ56Fe is also high in magnetite-rich cumulates at the onset of magnetite crystallization, while subsequent cumulates exhibit lower and variable δ56Fe principally reflecting fractionation of and modal variations in magnetite, pyroxene and fayalitic olivine. The overall relationships for δ56Fe are consistent with positive mineral - liquid Fe isotope fractionation factors for magnetite and plagioclase, and negative to near zero values for pyroxene and olivine. These initial results are being integrated into a forward model of the Bushveld liquid line of descent and will be compared to complementary work on the Skaergaard intrusion.

Geographical variations in seasonal mortality across the United States: A bioclimatological approach

NASA Astrophysics Data System (ADS)

Kalkstein, Adam

2008-10-01

Human mortality exhibits a strong seasonal pattern with deaths in winter far exceeding those in the summer. Surprisingly, this seasonal trend is evident in all major cities across the United States, seemingly independent of climate. While the pattern itself is clear, its magnitude varies considerably across space, and it is not known if there is regional homogeneity among cities. Additionally, the causal mechanisms relating to pattern variability are not clearly understood. The goal of this study is to conduct a comprehensive geographic analysis of seasonal mortality across the United States, to uncover systematic regional differences in such mortality, and to determine what role weather plays in impacting seasonal mortality rates. Unique seasonal mortality curves were created for 28 Metropolitan Statistical Areas across the United States, and the amplitude and timing of mortality peaks were determined. In addition, seasonality was calculated for different demographic groups and causes of death. Meteorological factors were also evaluated as possible causal mechanisms. The findings here indicate that the seasonality of mortality exhibits strong spatial variation with the largest seasonal mortality amplitudes found in the southwestern United States and the smallest in the North, along with South Florida. In addition, there have been changes in the timing of seasonal mortality; the date of maximum mortality is occurring increasingly early in the year. Demographics also play an important role with women, Whites, and the elderly exhibiting the strongest seasonality in mortality. There is a strong connection between respiratory disease and other causes of death, implying a cause-effect relationship. Meteorology also plays an important role in seasonal mortality; variations in the frequency of certain air masses were associated with changes in the timing and amplitude of seasonal mortality. Finally, there were strong intra-regional similarities that exist among the examined cities, implying that environmental factors are more important than social factors in determining seasonal mortality response. This work begins to fill a large gap within the scientific literature concerning the causes, geographic variation, and meteorological influences on seasonal mortality. Additionally, these results will increase the forecasting capabilities of determining when and where winter mortality will reach unusually high levels.

Allelic Imbalance Is a Prevalent and Tissue-Specific Feature of the Mouse Transcriptome

PubMed Central

Pinter, Stefan F.; Colognori, David; Beliveau, Brian J.; Sadreyev, Ruslan I.; Payer, Bernhard; Yildirim, Eda; Wu, Chao-ting; Lee, Jeannie T.

2015-01-01

In mammals, several classes of monoallelic genes have been identified, including those subject to X-chromosome inactivation (XCI), genomic imprinting, and random monoallelic expression (RMAE). However, the extent to which these epigenetic phenomena are influenced by underlying genetic variation is unknown. Here we perform a systematic classification of allelic imbalance in mouse hybrids derived from reciprocal crosses of divergent strains. We observe that deviation from balanced biallelic expression is common, occurring in ∼20% of the mouse transcriptome in a given tissue. Allelic imbalance attributed to genotypic variation is by far the most prevalent class and typically is tissue-specific. However, some genotype-based imbalance is maintained across tissues and is associated with greater genetic variation, especially in 5′ and 3′ termini of transcripts. We further identify novel random monoallelic and imprinted genes and find that genotype can modify penetrance of parental origin even in the setting of large imprinted regions. Examination of nascent transcripts in single cells from inbred parental strains reveals that genes showing genotype-based imbalance in hybrids can also exhibit monoallelic expression in isogenic backgrounds. This surprising observation may suggest a competition between alleles and/or reflect the combined impact of cis- and trans-acting variation on expression of a given gene. Our findings provide novel insights into gene regulation and may be relevant to human genetic variation and disease. PMID:25858912

The Longterm Centimeter-band Total Flux and Linear Polarization Properties of the Pearson-Readhead Survey Sources

NASA Astrophysics Data System (ADS)

Aller, M. F.; Aller, H. D.; Hughes, P. A.

2001-12-01

Using centimeter-band total flux and linear polarization observations of the Pearson-Readhead sample sources systematically obtained with the UMRAO 26-m radio telescope during the past 16 years, we identify the range of variability properties and their temporal changes as functions of both optical and radio morphological classification. We find that our earlier statistical analysis, based on a time window of 6.4 years, did not delineate the full amplitude range of the total flux variability; further, several galaxies exhibit longterm, systematic changes or rather infrequent outbursts requiring long term observations for detection. Using radio classification as a delineator, we confirm, and find additional evidence, that significant changes in flux density can occur in steep spectrum and lobe-dominated objects as well as in compact, flat-spectrum objects. We find that statistically the time-averaged total flux density spectra steepen when longer time windows are included, which we attribute to a selection effect in the source sample. We have identified preferred orientations of the electric vector of the polarized emission (EVPA) in an unbiased manner in several sources, including several QSOs which have exhibited large variations in total flux while maintaining stable EVPAs, and compared these with orientations of the flow direction indicated by VLB morphology. We have looked for systematic, monotonic changes in EVPA which might be expected in the emission from a precessing jet, but none were identified. A Scargle periodogram analysis found no strong evidence for periodicity in any of the sample sources. We thank the NSF for grants AST-8815678, AST-9120224, AST-9421979, and AST-9900723 which provided partial support for this research. The operation of the 26-meter telescope is supported by the University of Michigan Department of Astronomy.

Poverty and common mental disorders in low and middle income countries: A systematic review✩

PubMed Central

Lund, Crick; Breen, Alison; Flisher, Alan J; Kakuma, Ritsuko; Corrigall, Joanne; Joska, John A; Swartz, Leslie; Patel, Vikram

2016-01-01

In spite of high levels of poverty in low and middle income countries (LMIC), and the high burden posed by common mental disorders (CMD), it is only in the last two decades that research has emerged that empirically addresses the relationship between poverty and CMD in these countries. We conducted a systematic review of the epidemiological literature in LMIC, with the aim of examining this relationship. Of 115 studies that were reviewed, most reported positive associations between a range of poverty indicators and CMD. In community-based studies, 73% and 79% of studies reported positive associations between a variety of poverty measures and CMD, 19% and 15% reported null associations and 8% and 6% reported negative associations, using bivariate and multivariate analyses respectively. However, closer examination of specific poverty dimensions revealed a complex picture, in which there was substantial variation between these dimensions. While variables such as education, food insecurity, housing, social class, socio-economic status and financial stress exhibit a relatively consistent and strong association with CMD, others such as income, employment and particularly consumption are more equivocal. There are several measurement and population factors that may explain variation in the strength of the relationship between poverty and CMD. By presenting a systematic review of the literature, this paper attempts to shift the debate from questions about whether poverty is associated with CMD in LMIC, to questions about which particular dimensions of poverty carry the strongest (or weakest) association. The relatively consistent association between CMD and a variety of poverty dimensions in LMIC serves to strengthen the case for the inclusion of mental health on the agenda of development agencies and in international targets such as the millenium development goals. PMID:20621748

Outburst of GX304-1 Monitored with INTEGRAL: Positive Correlation Between the Cyclotron Line Energy and Flux

NASA Technical Reports Server (NTRS)

Klochkov, D.; Doroshenko, V.; Santangelo, A.; Staubert, R.; Ferrigno, C.; Kretschmar, P.; Caballero, I.; Wilms, J.; Kreykenbohm, I.; Pottschmidt, I.;

Biogeographic patterns in life history traits of the Pan-American sandy beach isopod Excirolana braziliensis

NASA Astrophysics Data System (ADS)

Cardoso, Ricardo S.; Defeo, Omar

2004-11-01

Biogeographic patterns in life history traits of the Pan-American sandy beach isopod Excirolana braziliensis were analyzed to determine latitudinal variations along its distribution, from tropical (9°N) to temperate (39°S) sandy beaches in Atlantic and Pacific oceans. Population features exhibited systematic geographical patterns of variation: (1) an increase in individual sizes and growth rates towards temperate beaches, following an inverse relationship with mean water temperature of the surf zone; (2) a shift from almost continuous to seasonal growth from subtropical to temperate Atlantic beaches and a positive relationship between amplitude of intra-annual growth oscillations and temperature range; (3) a linear decrease in life span and an increase in natural mortality from temperate to subtropical beaches; and (4) an increase in the individual mass-at-size (length-mass relationship) from subtropical to temperate beaches. Analyses discriminated by sex were consistent with the patterns illustrated above. Local effects of temperature and beach morphodynamics are discussed. Our results demonstrate that the population dynamics of E. braziliensis is highly plastic over latitudinal gradients, with large-scale variations in temperature and concurrent environmental variables leading to an adjustment of the phenotype-environment relationship.

Variation of stream temperature among mesoscale habitats within stream reaches: southern Appalachians

Treesearch

S. Lynsey Long; C. Rhett. Jackson

2014-01-01

Stream mesoscale habitats have systematic topographic relationships to hyporheic flow patterns, which may create predictable temperature variation between mesoscale habitat types. We investigated whether systematic differences in temperature metrics occurred between mesoscale habitats within reaches of small streams tributary to the upper Little Tennessee River,...

Errors in measurements by ultrasonic thickness gauges caused by the variation in ultrasonic velocity in constructional steels and metal alloys

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kalinin, V.A.; Tarasenko, V.L.; Tselser, L.B.

1988-09-01

Numerical values of the variation in ultrasonic velocity in constructional metal alloys and the measurement errors related to them are systematized. The systematization is based on the measurement results of the group ultrasonic velocity made in the All-Union Scientific-Research Institute for Nondestructive Testing in 1983-1984 and also on the measurement results of the group velocity made by various authors. The variations in ultrasonic velocity were systematized for carbon, low-alloy, and medium-alloy constructional steels; high-alloy iron base alloys; nickel-base heat-resistant alloys; wrought aluminum constructional alloys; titanium alloys; and cast irons and copper alloys.

The varieties of speech to young children.

PubMed

Huttenlocher, Janellen; Vasilyeva, Marina; Waterfall, Heidi R; Vevea, Jack L; Hedges, Larry V

2007-09-01

This article examines caregiver speech to young children. The authors obtained several measures of the speech used to children during early language development (14-30 months). For all measures, they found substantial variation across individuals and subgroups. Speech patterns vary with caregiver education, and the differences are maintained over time. While there are distinct levels of complexity for different caregivers, there is a common pattern of increase across age within the range that characterizes each educational group. Thus, caregiver speech exhibits both long-standing patterns of linguistic behavior and adjustment for the interlocutor. This information about the variability of speech by individual caregivers provides a framework for systematic study of the role of input in language acquisition. PsycINFO Database Record (c) 2007 APA, all rights reserved

Investigations of the Hydrologic Cycle in the Arctic Climate System Using Water Isotopes

NASA Astrophysics Data System (ADS)

Kopec, Ben Gordon

Warming has caused widespread changes to the Arctic hydrologic cycle, indicated by sea ice reductions, the Greenland Ice Sheet (GIS) mass loss, and permafrost degradation. Understanding Arctic hydrologic processes is essential for quantifying hydrological responses to climate change. A valuable tool to study these responses is the hydrogen and oxygen isotope ratios of water. Studies presented here aim to both innovatively apply water isotopes with existing understanding, and gain new knowledge in isotope systematics. I present several studies here. First, I show that Arctic precipitation increases with enhanced evaporation due to sea ice reduction; each 100,000 km2 loss in sea ice area increases the fraction of Arctic sourced moisture in total precipitation by 11 to 18%. Second, I argue that vapor sublimated from the GIS significantly contributes to summer precipitation at Summit, Greenland. This conclusion is first supported by isotopic variations in the daily precipitation collected at Summit for three years, and then further verified by 30 annual isotopic cycles in a shallow ice core. The result is not only important for quantifying the current ice sheet mass balance, but also for inferences of paleoclimate from ice cores. Third, I demonstrate that local scale atmospheric circulation in the glacier-free strip of West Greenland is dominated by convergence of dry glacial air masses from the east and moist marine air masses from the west. The dynamics of this convergence are affected by both regional radiation balance differences and broader circulation patterns such as the North Atlantic Oscillation. Humidity variations associated with these air masses control local precipitation and lake evaporation. Finally, along the east-west moisture gradient in West Greenland, lake evaporation also exhibits systematic changes in rate and isotopic enrichment, a result that is important for lake sediment core research. I have made advances in understanding water isotope systematics, mostly related to deuterium excess. In particular, variations in the deltaD-delta 18O slope, both for meteoric water and for lake water, are shown to contain interpretable environmental information. I also show that simple equilibrium Rayleigh distillation alters deuterium excess, an effect that was underappreciated in previous work.

A systematic review of animal predation creating pierced shells: implications for the archaeological record of the Old World

PubMed Central

Rosin, Zuzanna M.; Tryjanowski, Piotr

2017-01-01

Background The shells of molluscs survive well in many sedimentary contexts and yield information about the diet of prehistoric humans. They also yield evidence of symbolic behaviours through their use as beads for body adornments. Researchers often analyse the location of perforations in shells to make judgements about their use as symbolic objects (e.g., beads), the assumption being that holes attributable to deliberate human behaviour are more likely to exhibit low variability in their anatomical locations, while holes attributable to natural processes yield more random perforations. However, there are non-anthropogenic factors that can cause perforations in shells and these may not be random. The aim of the study is compare the variation in holes in shells from archaeological sites from the Old World with the variation of holes in shells pierced by mollusc predators. Methods Three hundred and sixteen scientific papers were retrieved from online databases by using keywords, (e.g., ‘shell beads’; ‘pierced shells’; ‘drilling predators’); 79 of these publications enabled us to conduct a systematic review to qualitatively assess the location of the holes in the shells described in the published articles. In turn, 54 publications were used to assess the location of the holes in the shells made by non-human predators. Results Almost all archaeological sites described shells with holes in a variety of anatomical locations. High variation of hole-placement was found within the same species from the same site, as well as among sites. These results contrast with research on predatory molluscs, which tend to be more specific in where they attacked their prey. Gastropod and bivalve predators choose similar hole locations to humans. Discussion Based on figures in the analysed articles, variation in hole-location on pierced shells from archaeological sites was similar to variation in the placement of holes created by non-human animals. Importantly, we found that some predators choose similar hole locations to humans. We discuss these findings and identify factors researchers might want to consider when interpreting shells recovered from archaeological contexts. PMID:28123913

INVESTIGATION OF SYSTEMATIC EFFECTS IN KEPLER DATA: SEASONAL VARIATIONS IN THE LIGHT CURVE OF HAT-P-7b

DOE Office of Scientific and Technical Information (OSTI.GOV)

Van Eylen, V.; Lindholm Nielsen, M.; Hinrup, B.

2013-09-10

With years of Kepler data currently available, the measurement of variations in planetary transit depths over time can now be attempted. To do so, it is of primary importance to understand which systematic effects may affect the measurement of transits. We aim to measure the stability of Kepler measurements over years of observations. We present a study of the depth of about 500 transit events of the Hot Jupiter HAT-P-7b, using 14 quarters (Q0-Q13) of data from the Kepler satellite. We find a systematic variation in the depth of the primary transit, related to quarters of data and recurring yearly.more » These seasonal variations are about 1%. Within seasons, we find no evidence for trends. We speculate that the cause of the seasonal variations could be unknown field crowding or instrumental artifacts. Our results show that care must be taken when combining transits throughout different quarters of Kepler data. Measuring the relative planetary radius of HAT-P-7b without taking these systematic effects into account leads to unrealistically low error estimates. This effect could be present in all Kepler targets. If so, relative radius measurements of all Hot Jupiters to a precision much better than 1% are unrealistic.« less

Influence of atypical retardation pattern on the peripapillary retinal nerve fibre distribution assessed by scanning laser polarimetry and optical coherence tomography.

PubMed

Schrems, W A; Laemmer, R; Hoesl, L M; Horn, F K; Mardin, C Y; Kruse, F E; Tornow, R P

2011-10-01

To investigate the influence of atypical retardation pattern (ARP) on the distribution of peripapillary retinal nerve fibre layer (RNFL) thickness measured with scanning laser polarimetry in healthy individuals and to compare these results with RNFL thickness from spectral domain optical coherence tomography (OCT) in the same subjects. 120 healthy subjects were investigated in this study. All volunteers received detailed ophthalmological examination, GDx variable corneal compensation (VCC) and Spectralis-OCT. The subjects were divided into four subgroups according to their typical scan score (TSS): very typical with TSS=100, typical with 99 ≥ TSS ≥ 91, less typical with 90 ≥ TSS ≥ 81 and atypical with TSS ≤ 80. Deviations from very typical normal values were calculated for 32 sectors for each group. There was a systematic variation of the RNFL thickness deviation around the optic nerve head in the atypical group for the GDxVCC results. The highest percentage deviation of about 96% appeared temporal with decreasing deviation towards the superior and inferior sectors, and nasal sectors exhibited a deviation of 30%. Percentage deviations from very typical RNFL values decreased with increasing TSS. No systematic variation could be found if the RNFL thickness deviation between different TSS-groups was compared with the OCT results. The ARP has a major impact on the peripapillary RNFL distribution assessed by GDx VCC; thus, the TSS should be included in the standard printout.

Temperature Dependent Electron Transport Properties of Gold Nanoparticles and Composites: Scanning Tunneling Spectroscopy Investigations.

PubMed

Patil, Sumati; Datar, Suwarna; Dharmadhikari, C V

2018-03-01

Scanning tunneling spectroscopy (STS) is used for investigating variations in electronic properties of gold nanoparticles (AuNPs) and its composite with urethane-methacrylate comb polymer (UMCP) as function of temperature. Films are prepared by drop casting AuNPs and UMCP in desired manner on silicon substrates. Samples are further analyzed for morphology under scanning electron microscopy (SEM) and atomic force microscopy (AFM). STS measurements performed in temperature range of 33 °C to 142 °C show systematic variation in current versus voltage (I-V) curves, exhibiting semiconducting to metallic transition/Schottky behavior for different samples, depending upon preparation method and as function of temperature. During current versus time (I-t) measurement for AuNPs, random telegraphic noise is observed at room temperature. Random switching of tunneling current between two discrete levels is observed for this sample. Power spectra derived from I-t show 1/f2 dependence. Statistical analysis of fluctuations shows exponential behavior with time width τ ≈ 7 ms. Local density of states (LDOS) plots derived from I-V curves of each sample show systematic shift in valance/conduction band edge towards/away from Fermi level, with respect to increase in temperature. Schottky emission is best fitted electron emission mechanism for all samples over certain range of bias voltage. Schottky plots are used to calculate barrier heights and temperature dependent measurements helped in measuring activation energies for electron transport in all samples.

Thorium and uranium variations in Apollo 17 basalts, and K-U systematics

NASA Technical Reports Server (NTRS)

Laul, J. C.; Fruchter, J. S.

1976-01-01

It is found that Apollo 11 low-K and in particular Apollo 17 mare basalts show a wide range of Th/U ratios unlike other rocks; such variations cannot be explained by near surface crystal fractionation. A two-stage fractional crystallization-partial melting model involving a clinopyroxene cumulate as the major phase can explain the variations in Th/U ratios. Due to the Sm-Nd systematics constraint, several source cumulates are invoked to explain the observed Th/U continuum.

Local versus Generalized Phenotypes in Two Sympatric Aurelia Species: Understanding Jellyfish Ecology Using Genetics and Morphometrics

PubMed Central

Chiaverano, Luciano M.; Bayha, Keith W.; Graham, William M.

2016-01-01

For individuals living in environmentally heterogeneous environments, a key component for adaptation and persistence is the extent of phenotypic differentiation in response to local environmental conditions. In order to determine the extent of environmentally induced morphological variation in a natural population distributed along environmental gradients, it is necessary to account for potential genetic differences contributing to morphological differentiation. In this study, we set out to quantify geographic morphological variation in the moon jellyfish Aurelia exposed at the extremes of a latitudinal environmental gradient in the Gulf of Mexico (GoM). We used morphological data based on 28 characters, and genetic data taken from mitochondrial cytochrome oxidase I (COI) and nuclear internal transcribed spacer 1 (ITS-1). Molecular analyses revealed the presence of two genetically distinct species of Aurelia co-occurring in the GoM: Aurelia sp. 9 and Aurelia c.f. sp. 2, named for its divergence from (for COI) and similarity to (for ITS-1) Aurelia sp. 2 (Brazil). Neither species exhibited significant population genetic structure between the Northern and the Southeastern Gulf of Mexico; however, they differed greatly in the degree of geographic morphological variation. The morphology of Aurelia sp. 9 exhibited ecophenotypic plasticity and varied significantly between locations, while morphology of Aurelia c.f. sp. 2 was geographically invariant (i.e., canalized). The plastic, generalist medusae of Aurelia sp. 9 are likely able to produce environmentally-induced, “optimal” phenotypes that confer high relative fitness in different environments. In contrast, the non-plastic generalist individuals of Aurelia c.f. sp. 2 likely produce environmentally-independent phenotypes that provide the highest fitness across environments. These findings suggest the two Aurelia lineages co-occurring in the GoM were likely exposed to different past environmental conditions (i.e., different selective pressures) and evolved different strategies to cope with environmental variation. This study highlights the importance of using genetics and morphometric data to understand jellyfish ecology, evolution and systematics. PMID:27332545

Local versus Generalized Phenotypes in Two Sympatric Aurelia Species: Understanding Jellyfish Ecology Using Genetics and Morphometrics.

PubMed

Chiaverano, Luciano M; Bayha, Keith W; Graham, William M

2016-01-01

For individuals living in environmentally heterogeneous environments, a key component for adaptation and persistence is the extent of phenotypic differentiation in response to local environmental conditions. In order to determine the extent of environmentally induced morphological variation in a natural population distributed along environmental gradients, it is necessary to account for potential genetic differences contributing to morphological differentiation. In this study, we set out to quantify geographic morphological variation in the moon jellyfish Aurelia exposed at the extremes of a latitudinal environmental gradient in the Gulf of Mexico (GoM). We used morphological data based on 28 characters, and genetic data taken from mitochondrial cytochrome oxidase I (COI) and nuclear internal transcribed spacer 1 (ITS-1). Molecular analyses revealed the presence of two genetically distinct species of Aurelia co-occurring in the GoM: Aurelia sp. 9 and Aurelia c.f. sp. 2, named for its divergence from (for COI) and similarity to (for ITS-1) Aurelia sp. 2 (Brazil). Neither species exhibited significant population genetic structure between the Northern and the Southeastern Gulf of Mexico; however, they differed greatly in the degree of geographic morphological variation. The morphology of Aurelia sp. 9 exhibited ecophenotypic plasticity and varied significantly between locations, while morphology of Aurelia c.f. sp. 2 was geographically invariant (i.e., canalized). The plastic, generalist medusae of Aurelia sp. 9 are likely able to produce environmentally-induced, "optimal" phenotypes that confer high relative fitness in different environments. In contrast, the non-plastic generalist individuals of Aurelia c.f. sp. 2 likely produce environmentally-independent phenotypes that provide the highest fitness across environments. These findings suggest the two Aurelia lineages co-occurring in the GoM were likely exposed to different past environmental conditions (i.e., different selective pressures) and evolved different strategies to cope with environmental variation. This study highlights the importance of using genetics and morphometric data to understand jellyfish ecology, evolution and systematics.

To what extent is altitudinal variation of functional traits driven by genetic adaptation in European oak and beech?

PubMed

Bresson, Caroline C; Vitasse, Yann; Kremer, Antoine; Delzon, Sylvain

2011-11-01

The phenotypic responses of functional traits in natural populations are driven by genetic diversity and phenotypic plasticity. These two mechanisms enable trees to cope with rapid climate change. We studied two European temperate tree species (sessile oak and European beech), focusing on (i) in situ variations of leaf functional traits (morphological and physiological) along two altitudinal gradients and (ii) the extent to which these variations were under environmental and/or genetic control using a common garden experiment. For all traits, altitudinal trends tended to be highly consistent between species and transects. For both species, leaf mass per area displayed a positive linear correlation with altitude, whereas leaf size was negatively correlated with altitude. We also observed a significant increase in leaf physiological performance with increasing altitude: populations at high altitudes had higher maximum rates of assimilation, stomatal conductance and leaf nitrogen content than those at low altitudes. In the common garden experiment, genetic differentiation between populations accounted for 0-28% of total phenotypic variation. However, only two traits (leaf mass per area and nitrogen content) exhibited a significant cline. The combination of in situ and common garden experiments used here made it possible to demonstrate, for both species, a weaker effect of genetic variation than of variations in natural conditions, suggesting a strong effect of the environment on leaf functional traits. Finally, we demonstrated that intrapopulation variability was systematically higher than interpopulation variability, whatever the functional trait considered, indicating a high potential capacity to adapt to climate change.

Leaf Photosynthetic Parameters Related to Biomass Accumulation in a Global Rice Diversity Survey1[OPEN

PubMed Central

Zheng, Guangyong; Hamdani, Saber; Essemine, Jemaa; Song, Qingfeng; Wang, Hongru

2017-01-01

Mining natural variations is a major approach to identify new options to improve crop light use efficiency. So far, successes in identifying photosynthetic parameters positively related to crop biomass accumulation through this approach are scarce, possibly due to the earlier emphasis on properties related to leaf instead of canopy photosynthetic efficiency. This study aims to uncover rice (Oryza sativa) natural variations to identify leaf physiological parameters that are highly correlated with biomass accumulation, a surrogate of canopy photosynthesis. To do this, we systematically investigated 14 photosynthetic parameters and four morphological traits in a rice population, which consists of 204 U.S. Department of Agriculture-curated minicore accessions collected globally and 11 elite Chinese rice cultivars in both Beijing and Shanghai. To identify key components responsible for the variance of biomass accumulation, we applied a stepwise feature-selection approach based on linear regression models. Although there are large variations in photosynthetic parameters measured in different environments, we observed that photosynthetic rate under low light (Alow) was highly related to biomass accumulation and also exhibited high genomic inheritability in both environments, suggesting its great potential to be used as a target for future rice breeding programs. Large variations in Alow among modern rice cultivars further suggest the great potential of using this parameter in contemporary rice breeding for the improvement of biomass and, hence, yield potential. PMID:28739819

Determinants of the efficiency of photon upconversion by triplet-triplet annihilation in the solid state: zinc porphyrin derivatives in PVA.

PubMed

Rautela, Ranjana; Joshi, Neeraj K; Novakovic, Sacha; Wong, Wallace W H; White, Jonathan M; Ghiggino, Kenneth P; Paige, Matthew F; Steer, Ronald P

2017-08-30

Spectroscopic, photophysical and computational studies designed to expose and explain the differences in the efficiencies of non-coherent photon upconversion (NCPU) by triplet-triplet annihilation (TTA) have been carried out for a new series of alkyl-substituted diphenyl and tetraphenyl zinc porphyrins, both in fluid solution and in solid films. Systematic variations in the alkyl-substitution of the phenyl groups in both the di- and tetraphenyl porphyrins introduces small, but well-understood changes in their spectroscopic and photophysical properties and in their TTA efficiencies. In degassed toluene solution TTA occurs for all derivatives and produces the fluorescent S 2 product states in all cases. In PVA matrices, however, none of the di-phenylporphyrins exhibit measurable NCPU whereas all the tetraphenyl-substituted compounds remain upconversion-active. In PVA the NCPU efficiencies of the zinc tetraphenylporphyrins vary significantly with their steric characteristics; the most sterically crowded tetraphenyl derivative exhibits the greatest efficiency. DFT-D computations have been undertaken and help reveal the sources of these differences.

Low-Temperature Photochemically Activated Amorphous Indium-Gallium-Zinc Oxide for Highly Stable Room-Temperature Gas Sensors.

PubMed

Jaisutti, Rawat; Kim, Jaeyoung; Park, Sung Kyu; Kim, Yong-Hoon

2016-08-10

We report on highly stable amorphous indium-gallium-zinc oxide (IGZO) gas sensors for ultraviolet (UV)-activated room-temperature detection of volatile organic compounds (VOCs). The IGZO sensors fabricated by a low-temperature photochemical activation process and exhibiting two orders higher photocurrent compared to conventional zinc oxide sensors, allowed high gas sensitivity against various VOCs even at room temperature. From a systematic analysis, it was found that by increasing the UV intensity, the gas sensitivity, response time, and recovery behavior of an IGZO sensor were strongly enhanced. In particular, under an UV intensity of 30 mW cm(-2), the IGZO sensor exhibited gas sensitivity, response time and recovery time of 37%, 37 and 53 s, respectively, against 750 ppm concentration of acetone gas. Moreover, the IGZO gas sensor had an excellent long-term stability showing around 6% variation in gas sensitivity over 70 days. These results strongly support a conclusion that a low-temperature solution-processed amorphous IGZO film can serve as a good candidate for room-temperature VOCs sensors for emerging wearable electronics.

PMN-PT based quaternary piezoceramics with enhanced piezoelectricity and temperature stability

NASA Astrophysics Data System (ADS)

Luo, Nengneng; Zhang, Shujun; Li, Qiang; Yan, Qingfeng; He, Wenhui; Zhang, Yiling; Shrout, Thomas R.

2014-05-01

The phase structure, piezoelectric, dielectric, and ferroelectric properties of (0.80 - x)PMN-0.10PFN-0.10PZ-xPT were investigated systematically. The morphotropic phase boundary (MPB) was confirmed to be 0.30 < x < 0.34. Both MPB compositions of x = 0.32 and x = 0.33 exhibit high piezoelectric coefficients d33 = 640 pC/N and 580 pC/N, electromechanical couplings kp of 0.53 and 0.52, respectively. Of particular importance is that the composition with x = 0.33 was found to process high field-induced piezoelectric strain coefficient d33* of 680 pm/V, exhibiting a minimal temperature-dependent behavior, being less than 8% in the temperature range of 25-165 °C, which can be further confirmed by d31, with a variation of less than 9%. The temperature-insensitive d33* values can be explained by the counterbalance of the ascending dielectric permittivity and descending polarization with increasing temperature. These features make the PMN-PT based quaternary MPB compositions promising for actuator applications demanding high temperature stability.

Black hole masses in active galactic nuclei

NASA Astrophysics Data System (ADS)

Denney, Kelly D.

2010-11-01

We present the complete results from two, high sampling-rate, multi-month, spectrophotometric reverberation mapping campaigns undertaken to obtain either new or improved Hbeta reverberation lag measurements for several relatively low-luminosity active galactic nuclei (AGNs). We have reliably measured the time delay between variations in the continuum and Hbeta emission line in seven local Seyfert 1 galaxies. These measurements are used to calculate the mass of the supermassive black hole at the center of each of these AGNs. We place our results in context to the most current calibration of the broad-line region (BLR) RBLR-L relationship, where our results remove many outliers and significantly reduce the scatter at the low-luminosity end of this relationship. A detailed analysis of the data from our high sampling rate, multi-month reverberation mapping campaign in 2007 reveals that the Hbeta emission region within the BLRs of several nearby AGNs exhibit a variety of kinematic behaviors. Through a velocity-resolved reverberation analysis of the broad Hbeta emission-line flux variations in our sample, we reconstruct velocity-resolved kinematic signals for our entire sample and clearly see evidence for outflowing, infalling, and virialized BLR gas motions in NGC 3227, NGC 3516, and NGC 5548, respectively. Finally, we explore the nature of systematic errors that can arise in measurements of black hole masses from single-epoch spectra of AGNs by utilizing the many epochs available for NGC 5548 and PG1229+204 from reverberation mapping databases. In particular, we examine systematics due to AGN variability, contamination due to constant spectral components (i.e., narrow lines and host galaxy flux), data quality (i.e., signal-to-noise ratio, S/N), and blending of spectral features. We investigate the effect that each of these systematics has on the precision and accuracy of single-epoch masses calculated from two commonly-used line-width measures by comparing these results to recent reverberation mapping studies. We then present an error budget which summarizes the minimum observable uncertainties as well as the amount of additional scatter and/or systematic offset that can be expected from the individual sources of error investigated.

On the Overdispersed Molecular Clock

PubMed Central

Takahata, Naoyuki

1987-01-01

Rates of molecular evolution at some loci are more irregular than described by simple Poisson processes. Three situations under which molecular evolution would not follow simple Poisson processes are reevaluated from the viewpoint of the neutrality hypothesis: (i) concomitant or multiple substitutions in a gene, (ii) fluctuating substitution rates in time caused by coupled effects of deleterious mutations and bottlenecks, and (iii) changes in the degree of selective constraints against a gene (neutral space) caused by successive substitutions. The common underlying assumption that these causes are lineage nonspecific excludes the case where mutation rates themselves change systematically among lineages or taxonomic groups, and severely limits the extent of variation in the number of substitutions among lineages. Even under this stringent condition, however, the third hypothesis, the fluctuating neutral space model, can generate fairly large variation. This is described by a time-dependent renewal process, which does not exhibit any episodic nature of molecular evolution. It is argued that the observed elevated variances in the number of nucleotide or amino acid substitutions do not immediately call for positive Darwinian selection in molecular evolution. PMID:3596230

Bacterial community variation in human body habitats across space and time.

PubMed

Costello, Elizabeth K; Lauber, Christian L; Hamady, Micah; Fierer, Noah; Gordon, Jeffrey I; Knight, Rob

2009-12-18

Elucidating the biogeography of bacterial communities on the human body is critical for establishing healthy baselines from which to detect differences associated with diseases. To obtain an integrated view of the spatial and temporal distribution of the human microbiota, we surveyed bacteria from up to 27 sites in seven to nine healthy adults on four occasions. We found that community composition was determined primarily by body habitat. Within habitats, interpersonal variability was high, whereas individuals exhibited minimal temporal variability. Several skin locations harbored more diverse communities than the gut and mouth, and skin locations differed in their community assembly patterns. These results indicate that our microbiota, although personalized, varies systematically across body habitats and time; such trends may ultimately reveal how microbiome changes cause or prevent disease.

Bacterial Community Variation in Human Body Habitats Across Space and Time

PubMed Central

Costello, Elizabeth K.; Lauber, Christian L.; Hamady, Micah; Fierer, Noah; Gordon, Jeffrey I.; Knight, Rob

2010-01-01

Elucidating the biogeography of bacterial communities on the human body is critical for establishing healthy baselines from which to detect differences associated with diseases. To obtain an integrated view of the spatial and temporal distribution of the human microbiota, we surveyed bacteria from up to 27 sites in 7–9 healthy adults on four occasions. We found that community composition was determined primarily by body habitat. Within habitats, interpersonal variability was high, while individuals exhibited minimal temporal variability. Several skin locations harbored more diverse communities than the gut and mouth, and skin locations differed in their community assembly patterns. These results indicate that our microbiota, although personalized, varies systematically across body habitats and time: such trends may ultimately reveal how microbiome changes cause or prevent disease. PMID:19892944

How well do satellite observations and models capture diurnal variation in aerosols over the Korean Peninsula?

NASA Astrophysics Data System (ADS)

Hyer, E. J.; Xian, P.; Campbell, J. R.

2016-12-01

Aerosol sources, sinks, and transport processes have important variations over the diurnal cycle. Advances in geostationary satellite observation have made it possible to retrieve aerosol properties over a larger fraction of the diurnal cycle in many areas. However, the conditions for retrieval of aerosol from space also have systematic diurnal variation, which must be considered when interpreting satellite data. We used surface PM2.5 observations from the Korean National Institute for Environmental Research, together with the dense network of AERONET sun photometers deployed in Korea for the KORUS-AQ mission in spring 2016, to examine diurnal variations in aerosol conditions and quantify the effect of systematic diurnal processes on daily integrated aerosol quantities of forcing and PM2.5 24-hour exposure. Time-resolved observations of aerosols from in situ data were compared to polar and geostationary satellite observations to evaluate these questions: 1) How well is diurnal variation observed in situ captured by satellite products? 2) Do the satellite products show evidence of systematic biases related to diurnally varying observing conditions? 3) What is the implication of diurnal variation for aerosol forcing estimates based on observations near solar noon? The diurnal variation diagnosed from observations was also compared to the output of the Navy Aerosol Analysis and Prediction System (NAAPS), to examine the ability of this model to capture aerosol diurnal variation. Finally, we discuss the implications of the observed diurnal variation for assimilation of aerosol observations into forecast models.

Analysis of copy number variations among cattle breeds

USDA-ARS?s Scientific Manuscript database

Genomic structural variation is an important and abundant source of genetic and phenotypic variation. Here we describe the first systematic and genome-wide analysis of copy number variations (CNVs) in the modern domesticated cattle using array comparative genomic hybridization (array CGH) and quanti...

An improved standardization procedure to remove systematic low frequency variability biases in GCM simulations

NASA Astrophysics Data System (ADS)

Mehrotra, Rajeshwar; Sharma, Ashish

2012-12-01

The quality of the absolute estimates of general circulation models (GCMs) calls into question the direct use of GCM outputs for climate change impact assessment studies, particularly at regional scales. Statistical correction of GCM output is often necessary when significant systematic biasesoccur between the modeled output and observations. A common procedure is to correct the GCM output by removing the systematic biases in low-order moments relative to observations or to reanalysis data at daily, monthly, or seasonal timescales. In this paper, we present an extension of a recently published nested bias correction (NBC) technique to correct for the low- as well as higher-order moments biases in the GCM-derived variables across selected multiple time-scales. The proposed recursive nested bias correction (RNBC) approach offers an improved basis for applying bias correction at multiple timescales over the original NBC procedure. The method ensures that the bias-corrected series exhibits improvements that are consistently spread over all of the timescales considered. Different variations of the approach starting from the standard NBC to the more complex recursive alternatives are tested to assess their impacts on a range of GCM-simulated atmospheric variables of interest in downscaling applications related to hydrology and water resources. Results of the study suggest that three to five iteration RNBCs are the most effective in removing distributional and persistence related biases across the timescales considered.

Extensive Natural Intraspecific Variation in Stoichiometric (C:N:P) Composition in Two Terrestrial Insect Species

PubMed Central

Bertram, S. M.; Bowen, M.; Kyle, M.; Schade, J. D.

2008-01-01

Heterotrophic organisms must obtain essential elements in sufficient quantities from their food. Because plants naturally exhibit extensive variation in their elemental content, it is important to quantify the within-species stoichiometric variation of consumers. If extensive stoichiometric variation exists, it may help explain consumer variation in life-history strategy and fitness. To date, however, research on stoichiometric variation has focused on interspecific differences and assumed minimal intraspecific differences. Here this assumption is tested. Natural variation is quantified in body stoichiometry of two terrestrial insects: the generalist field cricket, Gryllus texensis Cade and Otte (Orthoptera: Gryllidae) and a specialist curculionid weevil, Sabinia setosa (Le Conte) (Coleoptera: Curculionidae). Both species exhibited extensive intraspecific stoichiometric variation. Cricket body nitrogen content ranged from 8–12% and there was a four-fold difference in body phosphorus content, ranging from 0.32–1.27%. Body size explained half this stoichiometric variation, with larger individuals containing less nitrogen and phosphorus. Weevils exhibited an almost three-fold difference in body phosphorus content, ranging from 0.38–0.97%. Overall, the variation observed within each of these species is comparable to the variation previously observed across almost all terrestrial insect species. PMID:20298114

Analysis of copy number variations reveals differences among cattle breeds

USDA-ARS?s Scientific Manuscript database

Genomic structural variation is an important and abundant source of genetic and phenotypic variation. Here we describe the first systematic and genome-wide analysis of copy number variations (CNVs) in the modern domesticated cattle using array comparative genomic hybridization (array CGH) and quanti...

DOE Office of Scientific and Technical Information (OSTI.GOV)

McCulloch, M.T.; Gagan, M.K.; Mortimer, G.E.

A high-resolution (near weekly) Sr/Ca and oxygen isotopic record is presented for a coral from the Pandora Reef in the Great Barrier Reef (GBR) of Australia during the period of 1978 to 1984. The records are well correlated except for periods of high rainfall when river runoff has significantly modified the [delta][sup 18]O value of seawater. Using the Sr/Ca temperature calibration of De Villiers et al., the Sr/Ca records exhibit seasonally controlled cyclical SST (sea surface temperature) variations of from [approximately] 21 to [approximately] 28[degrees]C. During the very strong El Nino of 1982-1983, the Sr/CA systematics indicate a sharp dropmore » in the winter SST to [approximately] 18.5[degrees]C. This represents a temperature anomaly of -3[degrees]C which is approximately twice that given by the [delta][sup 18]O variations, suggesting an [approximately] x2 amplification of the anomaly by the Sr/Ca system, possibly due to the increasing dominance of inorganically controlled aragonite-seawater fractionation. The oxygen isotope systematics show the combined effects of both temperature and changing seawater [delta][sup 18]O values, the latter reflecting the influx of [sup 18]O-depleted runoff during periods of high rainfall. Due to the extremely low ([approximately] 10[sup [minus]3]) Sr and Ca contents of river runoff relative to seawater, it is possible to use the Sr/Ca thermometer to calculate temperatures independent of major floods and hence deconvolve the combined effects in the oxygen isotopic record of variable temperature and the [delta][sup 18]O value of seawater. Using this approach it is possible to quantitatively reproduce the volume of runoff from the Burdekin River during the periods of major flooding that occurred in early 1979 and 1981. The results of this study demonstrate that the combined use of high-resolution Sr/Ca and [delta][sup 18]O systematics in scleractinian corals is a powerful tool for providing quantitative constraints on past climate.« less

Protecting the fetus against HIV infection: a systematic review of placental transfer of antiretrovirals.

PubMed

McCormack, Shelley A; Best, Brookie M

2014-11-01

Maternal-to-fetal transfer of antiretroviral drugs contributes to prevention of vertical transmission of HIV. This systematic review discusses published studies containing data pertaining to the pharmacokinetics of placental transfer of antiretrovirals in humans, including paired cord and maternal plasma samples collected at the time of delivery as well as ex vivo placental perfusion models. Articles pertaining to placental transfer of antiretrovirals were identified from PubMed, from references of included articles, and from US Department of Health and Human Services Panel on Treatment of HIV-infected Pregnant Women and Prevention of Perinatal Transmission guidelines. Articles from non-human animal models or that had no original maternal-to-fetal transfer data were excluded. PRISMA guidelines were followed. A total of 103 published studies were identified. Data across studies appeared relatively consistent for the nucleoside reverse transcriptase inhibitors (NRTIs) and the non-nucleotide reverse transcriptase inhibitors (NNRTIs), with cord to maternal ratios approaching 1 for many of these agents. The protease inhibitors atazanavir and lopinavir exhibited consistent maternal-to-fetal transfer across studies, although the transfer may be influenced by variations in drug-binding proteins. The protease inhibitors indinavir, nelfinavir, and saquinavir exhibited unreliable placental transport, with cord blood concentrations that were frequently undetectable. Limited data, primarily from case reports, indicate that darunavir and raltegravir provide detectable placental transfer. These findings appear consistent with current guidelines of using two NRTIs plus an NNRTI, atazanavir/ritonavir, or lopinavir/ritonavir to maximize placental transfer as well as to optimally suppress maternal viral load. Darunavir/ritonavir and raltegravir may reasonably serve as second-line agents.

Barium isotopes reveal role of ocean circulation on barium cycling in the Atlantic

NASA Astrophysics Data System (ADS)

Bates, Stephanie L.; Hendry, Katharine R.; Pryer, Helena V.; Kinsley, Christopher W.; Pyle, Kimberley M.; Woodward, E. Malcolm S.; Horner, Tristan J.

2017-05-01

We diagnose the relative influences of local-scale biogeochemical cycling and regional-scale ocean circulation on Atlantic barium cycling by analysing four new depth profiles of dissolved Ba concentrations and isotope compositions from the South and tropical North Atlantic. These new profiles exhibit systematic vertical, zonal and meridional variations that reflect the influence of both local-scale barite cycling and large-scale ocean circulation. Epipelagic decoupling of dissolved Ba and Si reported previously in the tropics is also found to be associated with significant Ba isotope heterogeneity. As such, we contend that this decoupling originates from the depth segregation of opal and barite formation but is exacerbated by weak vertical mixing. Zonal influence from isotopically-'heavy' water masses in the western North Atlantic evidence the advective inflow of Ba-depleted Upper Labrador Sea Water, which is not seen in the eastern basin or the South Atlantic. Meridional variations in Atlantic Ba isotope systematics below 2000 m appear entirely controlled by conservative mixing. Using an inverse isotopic mixing model, we calculate the Ba isotope composition of the Ba-poor northern end-member as +0.45 ‰ and the Ba-rich southern end-member +0.26 ‰, relative to NIST SRM 3104a. The near-conservative behaviour of Ba below 2000 m indicates that Ba isotopes can serve as an independent tracer of the provenance of northern- versus southern-sourced water masses in the deep Atlantic Ocean. This finding may prove useful in palaeoceanographic studies, should appropriate sedimentary archives be identified, and offers new insights into the processes that cycle Ba in seawater.

Variation of axial and oblique astigmatism with accommodation across the visual field

PubMed Central

Liu, Tao; Thibos, Larry N.

2017-01-01

In this study we investigated the impact of accommodation on axial and oblique astigmatism along 12 meridians of the central 30° of visual field and explored the compensation of corneal first-surface astigmatism by the remainder of the eye's optical system. Our experimental evidence revealed no systematic effect of accommodation on either axial or oblique astigmatism for two adult populations (myopic and emmetropic eyes). Although a few subjects exhibited systematic changes in axial astigmatism during accommodation, the dioptric value of these changes was much smaller than the amount of accommodation. For most subjects, axial and oblique astigmatism of the whole eye are both less than for the cornea alone, which indicates a compensatory role for internal optics at all accommodative states in both central and peripheral vision. A new method for determining the eye's optical axis based on visual field maps of oblique astigmatism revealed that, on average, the optical axis is 4.8° temporal and 0.39° superior to the foveal line-of-sight in object space, which agrees with previous results obtained by different methodologies and implies that foveal astigmatism includes a small amount of oblique astigmatism (0.06 D on average). Customized optical models of each eye revealed that oblique astigmatism of the corneal first surface is negligible along the pupillary axis for emmetropic and myopic eyes. Individual variation in the eye's optical axis is due in part to misalignment of the corneal and internal components that is consistent with tilting of the crystalline lens relative to the pupillary axis. PMID:28362902

Effect of Indium nano-sandwiching on the structural and optical performance of ZnSe films

NASA Astrophysics Data System (ADS)

Al Garni, S. E.; Qasrawi, A. F.

In the current study, we attempted to explore the effects of the Indium nanosandwiching on the mechanical and optical properties of the physically evaporated ZnSe thin films by means of X-ray diffractions and ultraviolet spectrophotometry techniques. While the thickness of each layer of ZnSe was fixed at 1.0 μm, the thickness of the nanosandwiched Indium thin films was varied in the range of 25-100 nm. It was observed that the as grown ZnSe films exhibits cubic and hexagonal nature of crystallization as those of the ZnSe powders before the film deposition. The cubic phases weighs ∼70% of the structure. The analysis of this phases revealed that there is a systematic variation process presented by the decreasing of; the lattice constant, compressing strain, stress, stacking faults and dislocation intensity and increasing grain size resulted from increasing the Indium layer thickness in the range of 50-100 nm. In addition, the nanosandwiching of Indium between two layers of ZnSe is observed to enhance the absorbability of the ZnSe. Particularly, at incident photon energy of 2.38 eV the absorbability of the ZnSe films which are sandwiched with 100 nm Indium is increased by 13.8 times. Moreover, increasing the thickness of the Indium layer shrinks the optical energy band gap. These systematic variations in mechanical and optical properties are assigned to the better recrystallization process that is associated with Indium insertion which in turn allows total internal energy redistribution in the ZnSe films through the enlargement of grains.

Bias estimation for the Landsat 8 operational land imager

USGS Publications Warehouse

Morfitt, Ron; Vanderwerff, Kelly

2011-01-01

The Operational Land Imager (OLI) is a pushbroom sensor that will be a part of the Landsat Data Continuity Mission (LDCM). This instrument is the latest in the line of Landsat imagers, and will continue to expand the archive of calibrated earth imagery. An important step in producing a calibrated image from instrument data is accurately accounting for the bias of the imaging detectors. Bias variability is one factor that contributes to error in bias estimation for OLI. Typically, the bias is simply estimated by averaging dark data on a per-detector basis. However, data acquired during OLI pre-launch testing exhibited bias variation that correlated well with the variation in concurrently collected data from a special set of detectors on the focal plane. These detectors are sensitive to certain electronic effects but not directly to incoming electromagnetic radiation. A method of using data from these special detectors to estimate the bias of the imaging detectors was developed, but found not to be beneficial at typical radiance levels as the detectors respond slightly when the focal plane is illuminated. In addition to bias variability, a systematic bias error is introduced by the truncation performed by the spacecraft of the 14-bit instrument data to 12-bit integers. This systematic error can be estimated and removed on average, but the per pixel quantization error remains. This paper describes the variability of the bias, the effectiveness of a new approach to estimate and compensate for it, as well as the errors due to truncation and how they are reduced.

A Multi-Proxy Paradigm in the Pursuit of Ocean Paleoredox

NASA Astrophysics Data System (ADS)

Anbar, A. D.; Duan, Y.; Kendall, B.; Reinhard, C.; Severmann, S.; Lyons, T. W.

2011-12-01

The geologic record provides abundant evidence for variations in ocean oxygenation throughout Earth history. Expansion of ocean anoxic zones is expected in the future as a consequence of global climate change, with attendant effects on global nutrient inventories, carbon cycling and fluxes of trace greenhouse gases to the atmosphere. Therefore, studying ancient ocean redox variations not only teaches us about the history of the Earth system, but also provides insights into how the system may respond to analogous human perturbations. However, the extent, duration, causes, and consequences of most past variations are poorly understood. This problem motivates the development of paleoredox proxies, including novel stable isotope systems such as Mo, Fe, U and Tl. Experience with these emerging isotope systems demonstrates great promise but also many challenges. The Mo isotope system is illustrative. To first order, the geochemical cycling and isotope systematics of this element are straightforward, making it a useful proxy. However, critical unresolved issues include: (a) uncertainties in the ocean inputs through time; (b) ambiguities about fractionation mechanisms; (c) inadequate understanding of how modern analogs map to ancient systems. Similar challenges confront all the novel isotope systems. The way forward requires integration of multiple isotopic proxies, as well as information gleaned from careful analyses of element concentrations. For example, an episode of Mo enrichment in the 2.5 Ga Mt. McRae Shale is generally interpreted as resulting from buildup of Mo in seawater due to oxidative weathering. This enrichment is therefore thought to indicate a "whiff" of O2 in the environment prior to the Great Oxidation Event that began at 2.4 Ga. Molybdenum isotopes are consistent with this interpretation. However, Mo enrichment due to enhanced input from low-T hydrothermal sources in an anoxic regime cannot be completely excluded given the current state of knowledge of Mo isotope systematics from such sources. By considering sedimentary Fe enrichments together with Fe isotopes, we find that the Mo enrichment correlates with the telltale signature of a shelf-to-basin Fe redox "shuttle". Uranium isotopes also exhibit variations indicative of redox transformations. This multi-proxy dataset therefore paints a robust picture of trace metal redox cycling consistent with the "whiff" interpretation.

Tide-related seismic velocity changes across the English Channel

NASA Astrophysics Data System (ADS)

de Ridder, S.; Valova, V.; Curtis, A.

2016-12-01

Temporal changes in the seismic velocities in the Earth's subsurface are known to occur due to a range of phenomena including seasonal variations, magmatic activity, nonlinear healing after strong ground motion, and glacial loading and unloading. Our goal is to extend observations of small velocity changes towards shorter timescales. Earth tides caused by the gravitational attraction between the Earth and the Moon might affect seismic properties. If tidal velocity variations can be recovered from long range cross-correlations, and can also be coupled to stress-strain induced variations in the elastic properties, that would pave the way for systematic imaging of rheological properties of the upper crust. With this long-term goal, we studied data recorded between January 2010 and December 2015 by four broad-band instruments from the British Geological Survey network. One station is located in Cornwall, two in Devon, and one across the English Channel on the island of Jersey. Continuous seismic recordings of the vertical components of particle velocity were divided into one hour intervals, bandpass filtered between 0.02 and 0.11 Hz, spectrally whitened, and cross-correlated between station pairs. The resulting cross-correlations were stacked into bins corresponding to the average water levels observed at nearby ports resulting in cross-correlation traces as a function of water level, for each station pair. To detect temporal changes, a multi-window time-shift analysis is applied to these inter-station traces. We find a stretch factor that best translates one trace into another: this stretch is indicative of changes in average seismic velocities between the pair of tidal phases. We detected systematic seismic velocity variations as a function of water level. We find that increasing water level coincided with decreasing seismic velocities. Separating the data according to up- and down-going tidal tracts reveals that the observed velocity changes exhibit a time-lag, assuming that tide-induced strain is the dominant controlling factor. We discuss potential mechanisms for the observed seismic velocity dependency on water level including the effect of a thicker water layer on the dispersion characteristics of seismic velocities, and tidal loading related changes in the elastic properties of the subsurface.

Characterisation of signal enhancements achieved when utilizing a photon diode in deep Raman spectroscopy of tissue

PubMed Central

Vardaki, Martha Z.; Matousek, Pavel; Stone, Nicholas

2016-01-01

We characterise the performance of a beam enhancing element (‘photon diode’) for use in deep Raman spectroscopy (DRS) of biological tissues. The optical component enhances the number of laser photons coupled into a tissue sample by returning escaping photons back into it at the illumination zone. The method is compatible with transmission Raman spectroscopy, a deep Raman spectroscopy concept, and its implementation leads to considerable enhancement of detected Raman photon rates. In the past, the enhancement concept was demonstrated with a variety of samples (pharmaceutical tablets, tissue, etc) but it was not systematically characterized with biological tissues. In this study, we investigate the enhancing properties of the photon diode in the transmission Raman geometry as a function of: a) the depth and b) the optical properties of tissue samples. Liquid tissue phantoms were employed to facilitate systematic variation of optical properties. These were chosen to mimic optical properties of human tissues, including breast and prostate. The obtained results evidence that a photon diode can enhance Raman signals of tissues by a maximum of × 2.4, although it can also decrease the signals created towards the back of samples that exhibit high scattering or absorption properties. PMID:27375932

Is ozonation environmentally benign for reverse osmosis concentrate treatment? Four-level analysis on toxicity reduction based on organic matter fractionation.

PubMed

Weng, Jingxia; Jia, Huichao; Wu, Bing; Pan, Bingcai

2018-01-01

Ozonation is a promising option to treat reverse osmosis concentrate (ROC). However, a systematic understanding and assessment of ozonation on toxicity reduction is insufficient. In this study, ROC sampled from a typical industrial park wastewater treatment plant of China was fractionated into hydrophobic acid (HOA), hydrophobic base (HOB), hydrophobic neutral (HON), and hydrophilic fraction (HI). Systematic bioassays covering bacteria, algae, fish, and human cell lines were conducted to reveal the role of ozonation in toxicity variation of the four ROC fractions. HOA in the raw ROC exhibited the highest toxicity, followed by HON and HI. Ozonation significantly reduced total organic carbon (TOC) and UV 254 values in HOA, HON, and HI and their toxicity except in HOB. Correlation analysis indicated that chemical data (TOC and UV 254 ) of HOA and HON correlated well with their toxicities; however, poor correlations were observed for HOB and HI, suggesting that a battery of toxicity assays is necessary. This study indicates that TOC reduction during ozonation could not fully reflect the toxicity issue, and toxicity assessment is required in conjunction with the chemical data to evaluate the effectiveness of ozonation. Copyright © 2017 Elsevier Ltd. All rights reserved.

Intraindividual variation in levels of serum testosterone and other reproductive and adrenal hormones in men.

PubMed

Brambilla, Donald J; O'Donnell, Amy B; Matsumoto, Alvin M; McKinlay, John B

2007-12-01

Estimates of intraindividual variation in hormone levels provide the basis for interpreting hormone measurements clinically and for developing eligibility criteria for trials of hormone replacement therapy. However, reliable systematic estimates of such variation are lacking. To estimate intraindividual variation of serum total, free and bioavailable testosterone (T), dihydrotestosterone (DHT), SHBG, LH, dehydroepiandrosterone (DHEA), dehydroepiandrosterone sulphate (DHEAS), oestrone, oestradiol and cortisol, and the contributions of biological and assay variation to the total. Paired blood samples were obtained 1-3 days apart at entry and again 3 months and 6 months later (maximum six samples per subject). Each sample consisted of a pool of equal aliquots of two blood draws 20 min apart. Men aged 30-79 years were randomly selected from the respondents to the Boston Area Community Health Survey, a study of the health of the general population of Boston, MA, USA. Analysis was based on 132 men, including 121 who completed all six visits, 8 who completed the first two visits and 3 who completed the first four visits. Day-to-day and 3-month (long-term) intraindividual standard deviations, after transforming measurements to logarithms to eliminate the contribution of hormone level to intraindividual variation. Biological variation generally accounted for more of total intraindividual variation than did assay variation. Day-to-day biological variation accounted for more of the total than did long-term biological variation. Short-term variability was greater in hormones with pulsatile secretion (e.g. LH) than those that exhibit less ultradian variation. Depending on the hormone, the intraindividual standard deviations imply that a clinician can expect to see a difference exceeding 18-28% about half the time when two measurements are made on a subject. The difference will exceed 27-54% about a quarter of the time. Given the level of intraindividual variability in hormone levels found in this study, one sample is generally not sufficient to characterize an individual's hormone levels but collecting more than three is probably not warranted. This is true for clinical measurements and for hormone measurements used to determine eligibility for a clinical trial of hormone replacement therapy.

Altitude and intensity characteristics of parametric instability excited by an HF pump wave near the fifth electron harmonic

NASA Astrophysics Data System (ADS)

Jun, WU; Jian, WU; M, T. RIETVELD; I, HAGGSTROM; Haisheng, ZHAO; Zhengwen, XU

2017-12-01

An ionospheric heating experiment involving an O mode pump wave was carried out at European Incoherent Scatter Scientific Association site in Tromsø. The observation of the ultra high frequency radar illustrates the systematic variations of the enhanced ion line and plasma line in altitude and intensity as a function of the pump frequency. The analysis shows that those altitude variations are due to the thermal effect, and the intensity variations of the enhanced ion line are dependent on whether or not the enhanced ion acoustic wave satisfy the Bragg condition of radar. Moreover, a prediction that if the enhancement in electron temperature is suppressed, those systematic variations will be absent, is given.

Synthesis and antimalarial activity of new 4-amino-7-chloroquinolyl amides, sulfonamides, ureas and thioureas.

PubMed

Ekoue-Kovi, Kekeli; Yearick, Kimberly; Iwaniuk, Daniel P; Natarajan, Jayakumar K; Alumasa, John; de Dios, Angel C; Roepe, Paul D; Wolf, Christian

2009-01-01

We report the synthesis and in vitro antimalarial activities of more than 50 7-chloro-4-aminoquinolyl-derived sulfonamides 3-8 and 11-26, ureas 19-22, thioureas 23-26, and amides 27-54. Many of the CQ analogues prepared for this study showed submicromolar antimalarial activity versus HB3 (chloroquine sensitive) and Dd2 (chloroquine resistant strains of Plasmodium falciparum) and low resistance indices were obtained in most cases. Systematic variation of the side chain length and introduction of fluorinated aliphatic and aromatic termini revealed promising leads that overcome CQ resistance. In particular, sulfonamide 3 exhibiting a short side chain with a terminal dansyl moiety combined high antiplasmodial potency with a low resistance index and showed IC(50)s of 17.5 and 22.7 nM against HB3 and Dd2 parasites.

Synthesis, characterization, and ion-exchange properties of colloidal zeolite nanocrystals

NASA Astrophysics Data System (ADS)

Jawor, Anna; Jeong, Byeong-Heon; Hoek, Eric M. V.

2009-10-01

Here, we present physical-chemical properties of Linde type A (LTA) zeolite crystals synthesized via conventional hydrothermal and microwave heating methods. Both heating methods produced LTA crystals that were sub-micron in size, highly negatively charged, super-hydrophilic, and stable when dispersed in water. However, microwave heating produced relatively narrow crystal size distributions, required much shorter heating times, and did not significantly change composition, crystallinity, or surface chemistry. Moreover, microwave heating allowed systematic variation of crystal size by varying heating temperature and time during the crystallization reaction, thus producing a continuous gradient of crystal sizes ranging from about 90 to 300 nm. In ion-exchange studies, colloidal zeolites exhibited excellent sorption kinetics and capacity for divalent metal ions, suggesting their potential for use in water softening, scale inhibition, and scavenging of toxic metal ions from water.

Gene networks underlying convergent and pleiotropic phenotypes in a large and systematically-phenotyped cohort with heterogeneous developmental disorders.

PubMed

Andrews, Tallulah; Meader, Stephen; Vulto-van Silfhout, Anneke; Taylor, Avigail; Steinberg, Julia; Hehir-Kwa, Jayne; Pfundt, Rolph; de Leeuw, Nicole; de Vries, Bert B A; Webber, Caleb

2015-03-01

Readily-accessible and standardised capture of genotypic variation has revolutionised our understanding of the genetic contribution to disease. Unfortunately, the corresponding systematic capture of patient phenotypic variation needed to fully interpret the impact of genetic variation has lagged far behind. Exploiting deep and systematic phenotyping of a cohort of 197 patients presenting with heterogeneous developmental disorders and whose genomes harbour de novo CNVs, we systematically applied a range of commonly-used functional genomics approaches to identify the underlying molecular perturbations and their phenotypic impact. Grouping patients into 408 non-exclusive patient-phenotype groups, we identified a functional association amongst the genes disrupted in 209 (51%) groups. We find evidence for a significant number of molecular interactions amongst the association-contributing genes, including a single highly-interconnected network disrupted in 20% of patients with intellectual disability, and show using microcephaly how these molecular networks can be used as baits to identify additional members whose genes are variant in other patients with the same phenotype. Exploiting the systematic phenotyping of this cohort, we observe phenotypic concordance amongst patients whose variant genes contribute to the same functional association but note that (i) this relationship shows significant variation across the different approaches used to infer a commonly perturbed molecular pathway, and (ii) that the phenotypic similarities detected amongst patients who share the same inferred pathway perturbation result from these patients sharing many distinct phenotypes, rather than sharing a more specific phenotype, inferring that these pathways are best characterized by their pleiotropic effects.

Relative impact of key sources of systematic noise in Affymetrix and Illumina gene-expression microarray experiments.

PubMed

Kitchen, Robert R; Sabine, Vicky S; Simen, Arthur A; Dixon, J Michael; Bartlett, John M S; Sims, Andrew H

2011-12-01

Systematic processing noise, which includes batch effects, is very common in microarray experiments but is often ignored despite its potential to confound or compromise experimental results. Compromised results are most likely when re-analysing or integrating datasets from public repositories due to the different conditions under which each dataset is generated. To better understand the relative noise-contributions of various factors in experimental-design, we assessed several Illumina and Affymetrix datasets for technical variation between replicate hybridisations of Universal Human Reference (UHRR) and individual or pooled breast-tumour RNA. A varying degree of systematic noise was observed in each of the datasets, however in all cases the relative amount of variation between standard control RNA replicates was found to be greatest at earlier points in the sample-preparation workflow. For example, 40.6% of the total variation in reported expressions were attributed to replicate extractions, compared to 13.9% due to amplification/labelling and 10.8% between replicate hybridisations. Deliberate probe-wise batch-correction methods were effective in reducing the magnitude of this variation, although the level of improvement was dependent on the sources of noise included in the model. Systematic noise introduced at the chip, run, and experiment levels of a combined Illumina dataset were found to be highly dependent upon the experimental design. Both UHRR and pools of RNA, which were derived from the samples of interest, modelled technical variation well although the pools were significantly better correlated (4% average improvement) and better emulated the effects of systematic noise, over all probes, than the UHRRs. The effect of this noise was not uniform over all probes, with low GC-content probes found to be more vulnerable to batch variation than probes with a higher GC-content. The magnitude of systematic processing noise in a microarray experiment is variable across probes and experiments, however it is generally the case that procedures earlier in the sample-preparation workflow are liable to introduce the most noise. Careful experimental design is important to protect against noise, detailed meta-data should always be provided, and diagnostic procedures should be routinely performed prior to downstream analyses for the detection of bias in microarray studies.

Relative impact of key sources of systematic noise in Affymetrix and Illumina gene-expression microarray experiments

PubMed Central

2011-01-01

Background Systematic processing noise, which includes batch effects, is very common in microarray experiments but is often ignored despite its potential to confound or compromise experimental results. Compromised results are most likely when re-analysing or integrating datasets from public repositories due to the different conditions under which each dataset is generated. To better understand the relative noise-contributions of various factors in experimental-design, we assessed several Illumina and Affymetrix datasets for technical variation between replicate hybridisations of Universal Human Reference (UHRR) and individual or pooled breast-tumour RNA. Results A varying degree of systematic noise was observed in each of the datasets, however in all cases the relative amount of variation between standard control RNA replicates was found to be greatest at earlier points in the sample-preparation workflow. For example, 40.6% of the total variation in reported expressions were attributed to replicate extractions, compared to 13.9% due to amplification/labelling and 10.8% between replicate hybridisations. Deliberate probe-wise batch-correction methods were effective in reducing the magnitude of this variation, although the level of improvement was dependent on the sources of noise included in the model. Systematic noise introduced at the chip, run, and experiment levels of a combined Illumina dataset were found to be highly dependant upon the experimental design. Both UHRR and pools of RNA, which were derived from the samples of interest, modelled technical variation well although the pools were significantly better correlated (4% average improvement) and better emulated the effects of systematic noise, over all probes, than the UHRRs. The effect of this noise was not uniform over all probes, with low GC-content probes found to be more vulnerable to batch variation than probes with a higher GC-content. Conclusions The magnitude of systematic processing noise in a microarray experiment is variable across probes and experiments, however it is generally the case that procedures earlier in the sample-preparation workflow are liable to introduce the most noise. Careful experimental design is important to protect against noise, detailed meta-data should always be provided, and diagnostic procedures should be routinely performed prior to downstream analyses for the detection of bias in microarray studies. PMID:22133085

Diurnal Variations of the Flux Imbalance Over Homogeneous and Heterogeneous Landscapes

NASA Astrophysics Data System (ADS)

Zhou, Yanzhao; Li, Dan; Liu, Heping; Li, Xin

2018-05-01

It is well known that the sum of the turbulent sensible and latent heat fluxes as measured by the eddy-covariance method is systematically lower than the available energy (i.e., the net radiation minus the ground heat flux). We examine the separate and joint effects of diurnal and spatial variations of surface temperature on this flux imbalance in a dry convective boundary layer using the Weather Research and Forecasting model. Results show that, over homogeneous surfaces, the flux due to turbulent-organized structures is responsible for the imbalance, whereas over heterogeneous surfaces, the flux due to mesoscale or secondary circulations is the main contributor to the imbalance. Over homogeneous surfaces, the flux imbalance in free convective conditions exhibits a clear diurnal cycle, showing that the flux-imbalance magnitude slowly decreases during the morning period and rapidly increases during the afternoon period. However, in shear convective conditions, the flux-imbalance magnitude is much smaller, but slightly increases with time. The flux imbalance over heterogeneous surfaces exhibits a diurnal cycle under both free and shear convective conditions, which is similar to that over homogeneous surfaces in free convective conditions, and is also consistent with the general trend in the global observations. The rapid increase in the flux-imbalance magnitude during the afternoon period is mainly caused by the afternoon decay of the turbulent kinetic energy (TKE). Interestingly, over heterogeneous surfaces, the flux imbalance is linearly related to the TKE and the difference between the potential temperature and surface temperature, ΔT; the larger the TKE and ΔT values, the smaller the flux-imbalance magnitude.

Detection of contaminated pixels based on the short-term continuity of NDVI and correction using spatio-temporal continuity

NASA Astrophysics Data System (ADS)

Cho, A.-Ra; Suh, Myoung-Seok

2013-08-01

The present study developed and assessed a correction technique (CSaTC: Correction based on Spatial and Temporal Continuity) for the detection and correction of contaminated Normalized Difference Vegetation Index (NDVI) time series data. Global Inventory Modeling and Mapping Studies (GIMMS) NDVI data from 1982 to 2006 with a 15-day period and an 8-km spatial resolution was used. CSaTC utilizes short-term continuity of vegetation to detect contaminated pixels, and then, corrects the detected pixels using the spatio-temporal continuity of vegetation. CSaTC was applied to the NDVI data over the East Asian region, which exhibits diverse seasonal and interannual variations in vegetation activities. The correction skill of CSaTC was compared to two previously applied methods, IDR (iterative Interpolation for Data Reconstruction) and Park et al. (2011) using GIMMS NDVI data. CSaTC reasonably resolved the overcorrection and spreading phenomenon caused by excessive correction of Park et al. (2011). The validation using the simulated NDVI time series data showed that CSaTC shows a systematically better correction skill in bias and RMSE irrespective of phenology types of vegetation and noise levels. In general, CSaTC showed a good recovery of the contaminated data appearing over the short-term period on a level similar to that obtained using the IDR technique. In addition, it captured the multi-peak of NDVI, and the germination and defoliating patterns more accurately than that by IDR, which overly compensates for seasons with a high temporal variation and where NDVI data exhibit multi-peaks.

Systematic documentation and analysis of human genetic variation in hemoglobinopathies using the microattribution approach.

PubMed

Giardine, Belinda; Borg, Joseph; Higgs, Douglas R; Peterson, Kenneth R; Philipsen, Sjaak; Maglott, Donna; Singleton, Belinda K; Anstee, David J; Basak, A Nazli; Clark, Barnaby; Costa, Flavia C; Faustino, Paula; Fedosyuk, Halyna; Felice, Alex E; Francina, Alain; Galanello, Renzo; Gallivan, Monica V E; Georgitsi, Marianthi; Gibbons, Richard J; Giordano, Piero C; Harteveld, Cornelis L; Hoyer, James D; Jarvis, Martin; Joly, Philippe; Kanavakis, Emmanuel; Kollia, Panagoula; Menzel, Stephan; Miller, Webb; Moradkhani, Kamran; Old, John; Papachatzopoulou, Adamantia; Papadakis, Manoussos N; Papadopoulos, Petros; Pavlovic, Sonja; Perseu, Lucia; Radmilovic, Milena; Riemer, Cathy; Satta, Stefania; Schrijver, Iris; Stojiljkovic, Maja; Thein, Swee Lay; Traeger-Synodinos, Jan; Tully, Ray; Wada, Takahito; Waye, John S; Wiemann, Claudia; Zukic, Branka; Chui, David H K; Wajcman, Henri; Hardison, Ross C; Patrinos, George P

2011-03-20

We developed a series of interrelated locus-specific databases to store all published and unpublished genetic variation related to hemoglobinopathies and thalassemia and implemented microattribution to encourage submission of unpublished observations of genetic variation to these public repositories. A total of 1,941 unique genetic variants in 37 genes, encoding globins and other erythroid proteins, are currently documented in these databases, with reciprocal attribution of microcitations to data contributors. Our project provides the first example of implementing microattribution to incentivise submission of all known genetic variation in a defined system. It has demonstrably increased the reporting of human variants, leading to a comprehensive online resource for systematically describing human genetic variation in the globin genes and other genes contributing to hemoglobinopathies and thalassemias. The principles established here will serve as a model for other systems and for the analysis of other common and/or complex human genetic diseases.

Experimental evidence for convergent evolution of maternal care heuristics in industrialized and small-scale populations.

PubMed

Kushnick, Geoff; Hanowell, Ben; Kim, Jun-Hong; Langstieh, Banrida; Magnano, Vittorio; Oláh, Katalin

2015-06-01

Maternal care decision rules should evolve responsiveness to factors impinging on the fitness pay-offs of care. Because the caretaking environments common in industrialized and small-scale societies vary in predictable ways, we hypothesize that heuristics guiding maternal behaviour will also differ between these two types of populations. We used a factorial vignette experiment to elicit third-party judgements about likely caretaking decisions of a hypothetical mother and her child when various fitness-relevant factors (maternal age and access to resources, and offspring age, sex and quality) were varied systematically in seven populations-three industrialized and four small-scale. Despite considerable variation in responses, we found that three of five main effects, and the two severity effects, exhibited statistically significant industrialized/ small-scale population differences. All differences could be explained as adaptive solutions to industrialized versus small-scale caretaking environments. Further, we found gradients in the relationship between the population-specific estimates and national-level socio-economic indicators, further implicating important aspects of the variation in industrialized and small-scale caretaking environments in shaping heuristics. Although there is mounting evidence for a genetic component to human maternal behaviour, there is no current evidence for interpopulation variation in candidate genes. We nonetheless suggest that heuristics guiding maternal behaviour in diverse societies emerge via convergent evolution in response to similar selective pressures.

Using MODIS Cloud Regimes to Sort Diagnostic Signals of Aerosol-Cloud-Precipitation Interactions

PubMed Central

Oreopoulos, Lazaros; Cho, Nayeong; Lee, Dongmin

2018-01-01

Coincident multi-year measurements of aerosol, cloud, precipitation and radiation at near-global scales are analyzed to diagnose their apparent relationships as suggestive of interactions previously proposed based on theoretical, observational, and model constructs. Specifically, we examine whether differences in aerosol loading in separate observations go along with consistently different precipitation, cloud properties, and cloud radiative effects. Our analysis uses a cloud regime (CR) framework to dissect and sort the results. The CRs come from the Moderate Resolution Imaging Spectroradiometer (MODIS) sensor and are defined as distinct groups of cloud systems with similar co-variations of cloud top pressure and cloud optical thickness. Aerosol optical depth used as proxy for aerosol loading comes from two sources, MODIS observations, and the MERRA-2 re-analysis, and its variability is defined with respect to local seasonal climatologies. The choice of aerosol dataset impacts our results substantially. We also find that the responses of the marine and continental component of a CR are frequently quite disparate. Overall, CRs dominated by warm clouds tend to exhibit less ambiguous signals, but also have more uncertainty with regard to precipitation changes. Finally, we find weak, but occasionally systematic co-variations of select meteorological indicators and aerosol, which serves as a sober reminder that ascribing changes in cloud and cloud-affected variables solely to aerosol variations is precarious. PMID:29651373

Using MODIS Cloud Regimes to Sort Diagnostic Signals of Aerosol-Cloud-Precipitation Interactions.

PubMed

Oreopoulos, Lazaros; Cho, Nayeong; Lee, Dongmin

2017-05-27

Coincident multi-year measurements of aerosol, cloud, precipitation and radiation at near-global scales are analyzed to diagnose their apparent relationships as suggestive of interactions previously proposed based on theoretical, observational, and model constructs. Specifically, we examine whether differences in aerosol loading in separate observations go along with consistently different precipitation, cloud properties, and cloud radiative effects. Our analysis uses a cloud regime (CR) framework to dissect and sort the results. The CRs come from the Moderate Resolution Imaging Spectroradiometer (MODIS) sensor and are defined as distinct groups of cloud systems with similar co-variations of cloud top pressure and cloud optical thickness. Aerosol optical depth used as proxy for aerosol loading comes from two sources, MODIS observations, and the MERRA-2 re-analysis, and its variability is defined with respect to local seasonal climatologies. The choice of aerosol dataset impacts our results substantially. We also find that the responses of the marine and continental component of a CR are frequently quite disparate. Overall, CRs dominated by warm clouds tend to exhibit less ambiguous signals, but also have more uncertainty with regard to precipitation changes. Finally, we find weak, but occasionally systematic co-variations of select meteorological indicators and aerosol, which serves as a sober reminder that ascribing changes in cloud and cloud-affected variables solely to aerosol variations is precarious.

Interaction of Theory and Practice to Assess External Validity.

PubMed

Leviton, Laura C; Trujillo, Mathew D

2016-01-18

Variations in local context bedevil the assessment of external validity: the ability to generalize about effects of treatments. For evaluation, the challenges of assessing external validity are intimately tied to the translation and spread of evidence-based interventions. This makes external validity a question for decision makers, who need to determine whether to endorse, fund, or adopt interventions that were found to be effective and how to ensure high quality once they spread. To present the rationale for using theory to assess external validity and the value of more systematic interaction of theory and practice. We review advances in external validity, program theory, practitioner expertise, and local adaptation. Examples are provided for program theory, its adaptation to diverse contexts, and generalizing to contexts that have not yet been studied. The often critical role of practitioner experience is illustrated in these examples. Work is described that the Robert Wood Johnson Foundation is supporting to study treatment variation and context more systematically. Researchers and developers generally see a limited range of contexts in which the intervention is implemented. Individual practitioners see a different and often a wider range of contexts, albeit not a systematic sample. Organized and taken together, however, practitioner experiences can inform external validity by challenging the developers and researchers to consider a wider range of contexts. Researchers have developed a variety of ways to adapt interventions in light of such challenges. In systematic programs of inquiry, as opposed to individual studies, the problems of context can be better addressed. Evaluators have advocated an interaction of theory and practice for many years, but the process can be made more systematic and useful. Systematic interaction can set priorities for assessment of external validity by examining the prevalence and importance of context features and treatment variations. Practitioner interaction with researchers and developers can assist in sharpening program theory, reducing uncertainty about treatment variations that are consistent or inconsistent with the theory, inductively ruling out the ones that are harmful or irrelevant, and helping set priorities for more rigorous study of context and treatment variation. © The Author(s) 2016.

Systematic, Cross-Cortex Variation in Neuron Numbers in Rodents and Primates

PubMed Central

Charvet, Christine J.; Cahalane, Diarmuid J.; Finlay, Barbara L.

2015-01-01

Uniformity, local variability, and systematic variation in neuron numbers per unit of cortical surface area across species and cortical areas have been claimed to characterize the isocortex. Resolving these claims has been difficult, because species, techniques, and cortical areas vary across studies. We present a stereological assessment of neuron numbers in layers II–IV and V–VI per unit of cortical surface area across the isocortex in rodents (hamster, Mesocricetus auratus; agouti, Dasyprocta azarae; paca, Cuniculus paca) and primates (owl monkey, Aotus trivigratus; tamarin, Saguinus midas; capuchin, Cebus apella); these chosen to vary systematically in cortical size. The contributions of species, cortical areas, and techniques (stereology, “isotropic fractionator”) to neuron estimates were assessed. Neurons per unit of cortical surface area increase across the rostro-caudal (RC) axis in primates (varying by a factor of 1.64–2.13 across the rostral and caudal poles) but less in rodents (varying by a factor of 1.15–1.54). Layer II–IV neurons account for most of this variation. When integrated into the context of species variation, and this RC gradient in neuron numbers, conflicts between studies can be accounted for. The RC variation in isocortical neurons in adulthood mirrors the gradients in neurogenesis duration in development. PMID:23960207

Helical tomotherapy setup variations in canine nasal tumor patients immobilized with a bite block.

PubMed

Kubicek, Lyndsay N; Seo, Songwon; Chappell, Richard J; Jeraj, Robert; Forrest, Lisa J

2012-01-01

The purpose of our study was to compare setup variation in four degrees of freedom (vertical, longitudinal, lateral, and roll) between canine nasal tumor patients immobilized with a mattress and bite block, versus a mattress alone. Our secondary aim was to define a clinical target volume (CTV) to planning target volume (PTV) expansion margin based on our mean systematic error values associated with nasal tumor patients immobilized by a mattress and bite block. We evaluated six parameters for setup corrections: systematic error, random error, patient-patient variation in systematic errors, the magnitude of patient-specific random errors (root mean square [RMS]), distance error, and the variation of setup corrections from zero shift. The variations in all parameters were statistically smaller in the group immobilized by a mattress and bite block. The mean setup corrections in the mattress and bite block group ranged from 0.91 mm to 1.59 mm for the translational errors and 0.5°. Although most veterinary radiation facilities do not have access to Image-guided radiotherapy (IGRT), we identified a need for more rigid fixation, established the value of adding IGRT to veterinary radiation therapy, and define the CTV-PTV setup error margin for canine nasal tumor patients immobilized in a mattress and bite block. © 2012 Veterinary Radiology & Ultrasound.

Ferroelectric properties of PbxSr1-xTiO3 and its compositionally graded thin films grown on the highly oriented LaNiO3 buffered Pt /Ti/SiO2/Si substrates

NASA Astrophysics Data System (ADS)

Zhai, Jiwei; Yao, Xi; Xu, Zhengkui; Chen, Haydn

2006-08-01

Thin films of ferroelectric PbxSr1-xTiO3 (PST) with x =0.3-0.7 and graded composition were fabricated on LaNiO3 buffered Pt /Ti/SiO2/Si substrates by a sol-gel deposition method. The thin films crystallized into a single perovskite structure and exhibited highly (100) preferred orientation after postdeposition annealing at 650°C. The grain size of PST thin films systematically decreased with the increase of Sr content. Dielectric and ferroelectric properties were investigated as a function of temperature, frequency, and dc applied field. Pb0.6Sr0.4TiO3 films showed a dominant voltage dependence of dielectric constant with a high tunability in a temperature range of 25-230°C. The compositionally graded PST thin films with x =0.3-0.6 also showed the high tunability. The graded thin films exhibited a diffused phase transition accompanied by a diffused peak in the temperature variations of dielectric constants. This kind of thin films has a potential in a fabrication of a temperature stable tunable device.

Low temperature synthesis of silicon quantum dots with plasma chemistry control in dual frequency non-thermal plasmas.

PubMed

Sahu, Bibhuti Bhusan; Yin, Yongyi; Han, Jeon Geon; Shiratani, Masaharu

2016-06-21

The advanced materials process by non-thermal plasmas with a high plasma density allows the synthesis of small-to-big sized Si quantum dots by combining low-temperature deposition with superior crystalline quality in the background of an amorphous hydrogenated silicon nitride matrix. Here, we make quantum dot thin films in a reactive mixture of ammonia/silane/hydrogen utilizing dual-frequency capacitively coupled plasmas with high atomic hydrogen and nitrogen radical densities. Systematic data analysis using different film and plasma characterization tools reveals that the quantum dots with different sizes exhibit size dependent film properties, which are sensitively dependent on plasma characteristics. These films exhibit intense photoluminescence in the visible range with violet to orange colors and with narrow to broad widths (∼0.3-0.9 eV). The observed luminescence behavior can come from the quantum confinement effect, quasi-direct band-to-band recombination, and variation of atomic hydrogen and nitrogen radicals in the film growth network. The high luminescence yields in the visible range of the spectrum and size-tunable low-temperature synthesis with plasma and radical control make these quantum dot films good candidates for light emitting applications.

Spatio-Temporal Regression Based Clustering of Precipitation Extremes in a Presence of Systematically Missing Covariates

NASA Astrophysics Data System (ADS)

Kaiser, Olga; Martius, Olivia; Horenko, Illia

2017-04-01

Regression based Generalized Pareto Distribution (GPD) models are often used to describe the dynamics of hydrological threshold excesses relying on the explicit availability of all of the relevant covariates. But, in real application the complete set of relevant covariates might be not available. In this context, it was shown that under weak assumptions the influence coming from systematically missing covariates can be reflected by a nonstationary and nonhomogenous dynamics. We present a data-driven, semiparametric and an adaptive approach for spatio-temporal regression based clustering of threshold excesses in a presence of systematically missing covariates. The nonstationary and nonhomogenous behavior of threshold excesses is describes by a set of local stationary GPD models, where the parameters are expressed as regression models, and a non-parametric spatio-temporal hidden switching process. Exploiting nonparametric Finite Element time-series analysis Methodology (FEM) with Bounded Variation of the model parameters (BV) for resolving the spatio-temporal switching process, the approach goes beyond strong a priori assumptions made is standard latent class models like Mixture Models and Hidden Markov Models. Additionally, the presented FEM-BV-GPD provides a pragmatic description of the corresponding spatial dependence structure by grouping together all locations that exhibit similar behavior of the switching process. The performance of the framework is demonstrated on daily accumulated precipitation series over 17 different locations in Switzerland from 1981 till 2013 - showing that the introduced approach allows for a better description of the historical data.

Experimental validation of systematically designed acoustic hyperbolic meta material slab exhibiting negative refraction

NASA Astrophysics Data System (ADS)

Christiansen, Rasmus E.; Sigmund, Ole

2016-09-01

This Letter reports on the experimental validation of a two-dimensional acoustic hyperbolic metamaterial slab optimized to exhibit negative refractive behavior. The slab was designed using a topology optimization based systematic design method allowing for tailoring the refractive behavior. The experimental results confirm the predicted refractive capability as well as the predicted transmission at an interface. The study simultaneously provides an estimate of the attenuation inside the slab stemming from the boundary layer effects—insight which can be utilized in the further design of the metamaterial slabs. The capability of tailoring the refractive behavior opens possibilities for different applications. For instance, a slab exhibiting zero refraction across a wide angular range is capable of funneling acoustic energy through it, while a material exhibiting the negative refractive behavior across a wide angular range provides lensing and collimating capabilities.

Evolutionary rates for multivariate traits: the role of selection and genetic variation

PubMed Central

Pitchers, William; Wolf, Jason B.; Tregenza, Tom; Hunt, John; Dworkin, Ian

2014-01-01

A fundamental question in evolutionary biology is the relative importance of selection and genetic architecture in determining evolutionary rates. Adaptive evolution can be described by the multivariate breeders' equation (), which predicts evolutionary change for a suite of phenotypic traits () as a product of directional selection acting on them (β) and the genetic variance–covariance matrix for those traits (G). Despite being empirically challenging to estimate, there are enough published estimates of G and β to allow for synthesis of general patterns across species. We use published estimates to test the hypotheses that there are systematic differences in the rate of evolution among trait types, and that these differences are, in part, due to genetic architecture. We find some evidence that sexually selected traits exhibit faster rates of evolution compared with life-history or morphological traits. This difference does not appear to be related to stronger selection on sexually selected traits. Using numerous proposed approaches to quantifying the shape, size and structure of G, we examine how these parameters relate to one another, and how they vary among taxonomic and trait groupings. Despite considerable variation, they do not explain the observed differences in evolutionary rates. PMID:25002697

Quantitative historical analysis uncovers a single dimension of complexity that structures global variation in human social organization

PubMed Central

Turchin, Peter; Currie, Thomas E.; Whitehouse, Harvey; François, Pieter; Feeney, Kevin; Mullins, Daniel; Hoyer, Daniel; Collins, Christina; Grohmann, Stephanie; Mendel-Gleason, Gavin; Turner, Edward; Dupeyron, Agathe; Cioni, Enrico; Reddish, Jenny; Levine, Jill; Jordan, Greine; Brandl, Eva; Williams, Alice; Cesaretti, Rudolf; Krueger, Marta; Ceccarelli, Alessandro; Figliulo-Rosswurm, Joe; Tuan, Po-Ju; Peregrine, Peter; Marciniak, Arkadiusz; Preiser-Kapeller, Johannes; Kradin, Nikolay; Korotayev, Andrey; Palmisano, Alessio; Baker, David; Bidmead, Julye; Bol, Peter; Christian, David; Cook, Connie; Covey, Alan; Feinman, Gary; Júlíusson, Árni Daníel; Kristinsson, Axel; Miksic, John; Mostern, Ruth; Petrie, Cameron; Rudiak-Gould, Peter; ter Haar, Barend; Wallace, Vesna; Mair, Victor; Xie, Liye; Baines, John; Bridges, Elizabeth; Manning, Joseph; Lockhart, Bruce; Bogaard, Amy; Spencer, Charles

2018-01-01

Do human societies from around the world exhibit similarities in the way that they are structured, and show commonalities in the ways that they have evolved? These are long-standing questions that have proven difficult to answer. To test between competing hypotheses, we constructed a massive repository of historical and archaeological information known as “Seshat: Global History Databank.” We systematically coded data on 414 societies from 30 regions around the world spanning the last 10,000 years. We were able to capture information on 51 variables reflecting nine characteristics of human societies, such as social scale, economy, features of governance, and information systems. Our analyses revealed that these different characteristics show strong relationships with each other and that a single principal component captures around three-quarters of the observed variation. Furthermore, we found that different characteristics of social complexity are highly predictable across different world regions. These results suggest that key aspects of social organization are functionally related and do indeed coevolve in predictable ways. Our findings highlight the power of the sciences and humanities working together to rigorously test hypotheses about general rules that may have shaped human history. PMID:29269395

Titanium stable isotopic variations in chondrites, achondrites and lunar rocks

NASA Astrophysics Data System (ADS)

Greber, Nicolas D.; Dauphas, Nicolas; Puchtel, Igor S.; Hofmann, Beda A.; Arndt, Nicholas T.

2017-09-01

Titanium isotopes are potential tracers of processes of evaporation/condensation in the solar nebula and magmatic differentiation in planetary bodies. To gain new insights into the processes that control Ti isotopic variations in planetary materials, 25 komatiites, 15 chondrites, 11 HED-clan meteorites, 5 angrites, 6 aubrites, a martian shergottite, and a KREEP-rich impact melt breccia have been analyzed for their mass-dependent Ti isotopic compositions, presented using the δ49Ti notation (deviation in permil of the 49Ti/47Ti ratio relative to the OL-Ti standard). No significant variation in δ49Ti is found among ordinary, enstatite, and carbonaceous chondrites, and the average chondritic δ49Ti value of +0.004 ± 0.010‰ is in excellent agreement with the published estimate for the bulk silicate Earth, the Moon, Mars, and the HED and angrite parent-bodies. The average δ49Ti value of komatiites of -0.001 ± 0.019‰ is also identical to that of the bulk silicate Earth and chondrites. OL-Ti has a Ti isotopic composition that is indistinguishable from chondrites and is therefore a suitable material for reporting δ49Ti values. Previously published isotope data on another highly refractory element, Ca, show measurable variations among chondrites. The decoupling between Ca and Ti isotope systematics most likely occurred during condensation in the solar nebula. Aubrites exhibit significant variations in δ49Ti, from -0.07 to +0.24‰. This is likely due to the uniquely reducing conditions under which the aubrite parent-body differentiated, allowing chalcophile Ti3+ and lithophile Ti4+ to co-exist. Consequently, the observed negative correlation between δ49Ti values and MgO concentrations among aubrites is interpreted to be the result of isotope fractionation driven by the different oxidation states of Ti in this environment, such that isotopically heavy Ti4+ was concentrated in the residual liquid during magmatic differentiation. Finally, KREEPy impact melt breccia SaU 169 exhibits a heavy δ49Ti value of +0.330 ± 0.034‰ which is interpreted to result from Ti isotopic fractionation during ilmenite precipitation in the late stages of lunar magma ocean crystallization. A Rayleigh distillation calculation predicts that a δ49Ti value of +0.330‰ is achieved after removal of 94% of Ti in ilmenite.

Growth, inter- and intraspecific variation, palaeobiogeography, taphonomy and systematics of the Cenozoic ghost shrimp Glypturus

PubMed Central

Klompmaker, Adiël A.; Hyžný, Matúš; Portell, Roger W.; Kowalewski, Michał

2015-01-01

Studies in systematic palaeontology are greatly aided when numerous, well-preserved specimens are available so that quantitative methods can be used to substantiate qualitative observations. This is often not the case for fossil decapod crustaceans due to their relatively low preservation potential. Here, we examined primarily two large collections of the well-preserved ghost shrimp Glypturus from the Holo-Pleistocene of Panama and the late Miocene of Florida. Using descriptive, bivariate, multivariate and geometric morphometric methods, two new species are described based on appendage material: Glypturus panamacanalensis sp. nov. and G. sikesi sp. nov. New characters are identified, and size-related and intraspecific variation are assessed for these taxa and modern G. acanthochirus. Taxonomic placement of single specimens from other localities was confirmed by multivariate methods. Furthermore, Glypturus is revised, especially with regard to Western Atlantic species that inhabited both carbonate and siliciclastic environments. Callianassa anguillensis, C. latidigata, and Neocallichirus? quisquellanus are referred to as Glypturus sp. until more material is available to determine the validity of these species. Diversity within Glypturus may thus be underestimated, thereby also impacting the assessment of phylogenetic relationships. Minor propodi appear under-represented relative to major propodi, suggesting a taphonomic bias. Single specimens of interest include a specimen of G. panamacanalensis sp. nov. exhibiting a peculiar swelling in the fixed finger and another showing damage on the propodal upper margin, suggesting failed predation or antagonistic behaviour. Glypturus is first found in the Oligocene in the Western Atlantic and may have expanded its palaeobiogeographical range since the Miocene. The genus was still present on the Pacific side of the Isthmus of Panama in the Holo-Pleistocene, but is only known from the Western Atlantic today, suggesting a relatively recent extinction on the Pacific side. PMID:26819570

Landscape position influences soil respiration variability and sensitivity to physiological drivers in mixed-use lands of Southern California, USA

NASA Astrophysics Data System (ADS)

Crum, Steven M.; Liang, Liyin L.; Jenerette, G. Darrel

2016-10-01

Linking variation in ecosystem functioning to physiological and landscape drivers has become an important research need for understanding ecosystem responses to global changes. We investigate how these contrasting scale-dependent ecosystem drivers influence soil respiration (Rs), a key ecosystem process, using in situ landscape surveys and experimental subsidies of water and labile carbon. Surveys and experiments were conducted in summer and winter seasons and were distributed along a coastal to desert climate gradient and among the dominant land use classes in Southern California, USA. We found that Rs decreased from lawn to agricultural and wildland land uses for both seasons and along the climate gradient in the summer while increasing along the climate gradient in the winter. Rs variation was positively correlated with soil temperature and negatively to soil moisture and substrate. Water additions increased Rs in wildland land uses, while urban land uses responded little or negatively. However, most land uses exhibited carbon limitation, with wildlands experiencing largest responses to labile carbon additions. These findings show that intensively managed land uses have increased rates, decreased spatial variation, and decreased sensitivity to environmental conditions in Rs compared to wildlands, while increasing aridity has the opposite effect. In linking scales, physiological drivers were correlated with Rs but landscape position influenced Rs by altering both the physiological drivers and the sensitivity to the drivers. Systematic evaluation of physiological and landscape variation provides a framework for understanding the effects of interactive global change drivers to ecosystem metabolism across multiple scales.

A systematic review of medical practice variation in OECD countries.

PubMed

Corallo, Ashley N; Croxford, Ruth; Goodman, David C; Bryan, Elisabeth L; Srivastava, Divya; Stukel, Therese A

2014-01-01

Major variations in medical practice have been documented internationally. Variations raise questions about the quality, equity, and efficiency of resource allocation and use, and have important implications for health care and health policy. To perform a systematic review of the peer-reviewed literature on medical practice variations in OECD countries. We searched MEDLINE to find publications on medical practice variations in OECD countries published between 2000 and 2011. We present an overview of the characteristics of published studies as well as the magnitude of variations for select high impact conditions. A total of 836 studies were included. Consistent with the gray literature, there were large variations across regions, hospitals and physician practices for almost every condition and procedure studied. Many studies focused on high-impact conditions, but very few looked at the causes or outcomes of medical practice variations. While there were an overwhelming number of publications on medical practice variations the coverage was broad and not often based on a theoretical construct. Future studies should focus on conditions and procedures that are clinically important, policy relevant, resource intensive, and have high levels of public awareness. Further study of the causes and consequences of variations is important. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

Comparable Wages, Inflation, and School Finance Equity

ERIC Educational Resources Information Center

Taylor, Lori L.

2006-01-01

A Comparable Wage Index (CWI) is an attractive mechanism for measuring geographic variations in the cost of education. A CWI measures uncontrollable variations in educator pay by observing systematic variations in the earnings of comparable workers who are not educators. Together, the 2000 census and the Occupational Employment Statistics survey…

Estimating Cross-Site Impact Variation in the Presence of Heteroscedasticity

ERIC Educational Resources Information Center

Bloom, Howard S.; Porter, Kristin E.; Weiss, Michael J.; Raudenbush, Stephen

2013-01-01

To date, evaluation research and policy analysis have focused mainly on average program impacts and paid little systematic attention to their variation. Recently, the growing number of multi-site randomized trials that are being planned and conducted make it increasingly feasible to study "cross-site" variation in impacts. Important…

Variation, certainty, evidence, and change in dental education: employing evidence-based dentistry in dental education.

PubMed

Marinho, V C; Richards, D; Niederman, R

2001-05-01

Variation in health care, and more particularly in dental care, was recently chronicled in a Readers Digest investigative report. The conclusions of this report are consistent with sound scientific studies conducted in various areas of health care, including dental care, which demonstrate substantial variation in the care provided to patients. This variation in care parallels the certainty with which clinicians and faculty members often articulate strongly held, but very different opinions. Using a case-based dental scenario, we present systematic evidence-based methods for accessing dental health care information, evaluating this information for validity and importance, and using this information to make informed curricular and clinical decisions. We also discuss barriers inhibiting these systematic approaches to evidence-based clinical decision making and methods for effectively promoting behavior change in health care professionals.

Meeting critical gate linewidth control needs at the 65 nm node

NASA Astrophysics Data System (ADS)

Mahorowala, Arpan; Halle, Scott; Gabor, Allen; Chu, William; Barberet, Alexandra; Samuels, Donald; Abdo, Amr; Tsou, Len; Yan, Wendy; Iseda, Seiji; Patel, Kaushal; Dirahoui, Bachir; Nomura, Asuka; Ahsan, Ishtiaq; Azam, Faisal; Berg, Gary; Brendler, Andrew; Zimmerman, Jeffrey; Faure, Tom

2006-03-01

With the nominal gate length at the 65 nm node being only 35 nm, controlling the critical dimension (CD) in polysilicon to within a few nanometers is essential to achieve a competitive power-to-performance ratio. Gate linewidths must be controlled, not only at the chip level so that the chip performs as the circuit designers and device engineers had intended, but also at the wafer level so that more chips with the optimum power-to-performance ratio are manufactured. Achieving tight across-chip linewidth variation (ACLV) and chip mean variation (CMV) is possible only if the mask-making, lithography, and etching processes are all controlled to very tight specifications. This paper identifies the various ACLV and CMV components, describes their root causes, and discusses a methodology to quantify them. For example, the site-to-site ACLV component is divided into systematic and random sub-components. The systematic component of the variation is attributed in part to pattern density variation across the field, and variation in exposure dose across the slit. The paper demonstrates our team's success in achieving the tight gate CD tolerances required for 65 nm technology. Certain key challenges faced, and methods employed to overcome them are described. For instance, the use of dose-compensation strategies to correct the small but systematic CD variations measured across the wafer, is described. Finally, the impact of immersion lithography on both ACLV and CMV is briefly discussed.

Calibration of Herschel SPIRE FTS observations at different spectral resolutions

NASA Astrophysics Data System (ADS)

Marchili, N.; Hopwood, R.; Fulton, T.; Polehampton, E. T.; Valtchanov, I.; Zaretski, J.; Naylor, D. A.; Griffin, M. J.; Imhof, P.; Lim, T.; Lu, N.; Makiwa, G.; Pearson, C.; Spencer, L.

2017-01-01

The SPIRE Fourier Transform Spectrometer on-board the Herschel Space Observatory had two standard spectral resolution modes for science observations: high resolution (HR) and low resolution (LR), which could also be performed in sequence (H+LR). A comparison of the HR and LR resolution spectra taken in this sequential mode revealed a systematic discrepancy in the continuum level. Analysing the data at different stages during standard pipeline processing demonstrates that the telescope and instrument emission affect HR and H+LR observations in a systematically different way. The origin of this difference is found to lie in the variation of both the telescope and instrument response functions, while it is triggered by fast variation of the instrument temperatures. As it is not possible to trace the evolution of the response functions using housekeeping data from the instrument subsystems, the calibration cannot be corrected analytically. Therefore, an empirical correction for LR spectra has been developed, which removes the systematic noise introduced by the variation of the response functions.

Atomic and electronic structure of Mo6S9-xIx nanowires

NASA Astrophysics Data System (ADS)

Meden, A.; Kodre, A.; Padeznik Gomilsek, J.; Arcon, I.; Vilfan, I.; Vrbanic, D.; Mrzel, A.; Mihailovic, D.

2005-09-01

Moybdenum-based subnanometre diameter nanowires are easy to synthesize and disperse, and they exhibit a variety of functional properties in which they are superior to other one-dimensional materials. However, further progress in the understanding of physical properties and the development of new and specific applications have so far been impeded by the fact that their structure was not accurately known. Here we report on a combination of systematic x-ray diffraction and extended x-ray absorption fine structure experiments, and first-principles theoretical structure calculations, which are used to determine the atomic skeletal structure of individual Mo6S9-xIx (MoSIx) nanowires, their packing arrangement within bundles and their electronic band structure. From this work we conclude that the variations in functional properties appear to arise from different stoichiometry, not skeletal structure. A supplementary data file is available from http://stacks.iop.org/0957-4484/16/1578

Effects of Uncertainty in TRMM Precipitation Radar Path Integrated Attenuation on Interannual Variations of Tropical Oceanic Rainfall

NASA Technical Reports Server (NTRS)

Robertson, Franklin R.; Fitzjarrald, Dan E.; Kummerow, Christian D.; Arnold, James E. (Technical Monitor)

2002-01-01

Considerable uncertainty surrounds the issue of whether precipitation over the tropical oceans (30 deg N/S) systematically changes with interannual sea-surface temperature (SST) anomalies that accompany El Nino (warm) and La Nina (cold) events. Time series of rainfall estimates from the Tropical Rainfall Measuring Mission (TRMM Precipitation Radar (PR) over the tropical oceans show marked differences with estimates from two TRMM Microwave Imager (TMI) passive microwave algorithms. We show that path-integrated attenuation derived from the effects of precipitation on the radar return from the ocean surface exhibits interannual variability that agrees closely with the TMI time series. Further analysis of the frequency distribution of PR (2A25 product) rain rates suggests that the algorithm incorporates the attenuation measurement in a very conservative fashion so as to optimize the instantaneous rain rates. Such an optimization appears to come at the expense of monitoring interannual climate variability.

Systematic study of the spin stiffness dependence on phosphorus alloying in the ferromagnetic semiconductor (Ga,Mn)As

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shihab, S.; Thevenard, L.; Bardeleben, H. J. von

2015-04-06

We study the dependence of the spin stiffness constant on the phosphorus concentration in the ferromagnetic semiconductor (Ga,Mn)(As,P) with the aim of determining whether alloying with phosphorus is detrimental, neutral, or advantageous to the spin stiffness. Time-resolved magneto-optical experiments are carried out in thin epilayers. Laser pulses excite two perpendicular standing spin wave modes, which are exchange related. We show that the first mode is spatially uniform across the layer corresponding to a k≈0 wavevector. From the two frequencies and k-vector spacings we obtain the spin stiffness constant for different phosphorus concentrations using weak surface pinning conditions. The mode assessmentmore » is checked by comparison to the spin stiffness obtained from domain pattern analysis for samples with out-of-plane magnetization. The spin stiffness is found to exhibit little variation with phosphorus concentration in contradiction with ab-initio predictions.« less

Systematic pharmacogenomics analysis of a Malay whole genome: proof of concept for personalized medicine.

PubMed

Salleh, Mohd Zaki; Teh, Lay Kek; Lee, Lian Shien; Ismet, Rose Iszati; Patowary, Ashok; Joshi, Kandarp; Pasha, Ayesha; Ahmed, Azni Zain; Janor, Roziah Mohd; Hamzah, Ahmad Sazali; Adam, Aishah; Yusoff, Khalid; Hoh, Boon Peng; Hatta, Fazleen Haslinda Mohd; Ismail, Mohamad Izwan; Scaria, Vinod; Sivasubbu, Sridhar

2013-01-01

With a higher throughput and lower cost in sequencing, second generation sequencing technology has immense potential for translation into clinical practice and in the realization of pharmacogenomics based patient care. The systematic analysis of whole genome sequences to assess patient to patient variability in pharmacokinetics and pharmacodynamics responses towards drugs would be the next step in future medicine in line with the vision of personalizing medicine. Genomic DNA obtained from a 55 years old, self-declared healthy, anonymous male of Malay descent was sequenced. The subject's mother died of lung cancer and the father had a history of schizophrenia and deceased at the age of 65 years old. A systematic, intuitive computational workflow/pipeline integrating custom algorithm in tandem with large datasets of variant annotations and gene functions for genetic variations with pharmacogenomics impact was developed. A comprehensive pathway map of drug transport, metabolism and action was used as a template to map non-synonymous variations with potential functional consequences. Over 3 million known variations and 100,898 novel variations in the Malay genome were identified. Further in-depth pharmacogenetics analysis revealed a total of 607 unique variants in 563 proteins, with the eventual identification of 4 drug transport genes, 2 drug metabolizing enzyme genes and 33 target genes harboring deleterious SNVs involved in pharmacological pathways, which could have a potential role in clinical settings. The current study successfully unravels the potential of personal genome sequencing in understanding the functionally relevant variations with potential influence on drug transport, metabolism and differential therapeutic outcomes. These will be essential for realizing personalized medicine through the use of comprehensive computational pipeline for systematic data mining and analysis.

Effect of Population Heterogenization on the Reproducibility of Mouse Behavior: A Multi-Laboratory Study

PubMed Central

Richter, S. Helene; Garner, Joseph P.; Zipser, Benjamin; Lewejohann, Lars; Sachser, Norbert; Touma, Chadi; Schindler, Britta; Chourbaji, Sabine; Brandwein, Christiane; Gass, Peter; van Stipdonk, Niek; van der Harst, Johanneke; Spruijt, Berry; Võikar, Vootele; Wolfer, David P.; Würbel, Hanno

2011-01-01

In animal experiments, animals, husbandry and test procedures are traditionally standardized to maximize test sensitivity and minimize animal use, assuming that this will also guarantee reproducibility. However, by reducing within-experiment variation, standardization may limit inference to the specific experimental conditions. Indeed, we have recently shown in mice that standardization may generate spurious results in behavioral tests, accounting for poor reproducibility, and that this can be avoided by population heterogenization through systematic variation of experimental conditions. Here, we examined whether a simple form of heterogenization effectively improves reproducibility of test results in a multi-laboratory situation. Each of six laboratories independently ordered 64 female mice of two inbred strains (C57BL/6NCrl, DBA/2NCrl) and examined them for strain differences in five commonly used behavioral tests under two different experimental designs. In the standardized design, experimental conditions were standardized as much as possible in each laboratory, while they were systematically varied with respect to the animals' test age and cage enrichment in the heterogenized design. Although heterogenization tended to improve reproducibility by increasing within-experiment variation relative to between-experiment variation, the effect was too weak to account for the large variation between laboratories. However, our findings confirm the potential of systematic heterogenization for improving reproducibility of animal experiments and highlight the need for effective and practicable heterogenization strategies. PMID:21305027

Systematic, cross-cortex variation in neuron numbers in rodents and primates.

PubMed

Charvet, Christine J; Cahalane, Diarmuid J; Finlay, Barbara L

2015-01-01

Uniformity, local variability, and systematic variation in neuron numbers per unit of cortical surface area across species and cortical areas have been claimed to characterize the isocortex. Resolving these claims has been difficult, because species, techniques, and cortical areas vary across studies. We present a stereological assessment of neuron numbers in layers II-IV and V-VI per unit of cortical surface area across the isocortex in rodents (hamster, Mesocricetus auratus; agouti, Dasyprocta azarae; paca, Cuniculus paca) and primates (owl monkey, Aotus trivigratus; tamarin, Saguinus midas; capuchin, Cebus apella); these chosen to vary systematically in cortical size. The contributions of species, cortical areas, and techniques (stereology, "isotropic fractionator") to neuron estimates were assessed. Neurons per unit of cortical surface area increase across the rostro-caudal (RC) axis in primates (varying by a factor of 1.64-2.13 across the rostral and caudal poles) but less in rodents (varying by a factor of 1.15-1.54). Layer II-IV neurons account for most of this variation. When integrated into the context of species variation, and this RC gradient in neuron numbers, conflicts between studies can be accounted for. The RC variation in isocortical neurons in adulthood mirrors the gradients in neurogenesis duration in development. © The Author 2013. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

Artifacts reduction in VIR/Dawn data.

PubMed

Carrozzo, F G; Raponi, A; De Sanctis, M C; Ammannito, E; Giardino, M; D'Aversa, E; Fonte, S; Tosi, F

2016-12-01

Remote sensing images are generally affected by different types of noise that degrade the quality of the spectral data (i.e., stripes and spikes). Hyperspectral images returned by a Visible and InfraRed (VIR) spectrometer onboard the NASA Dawn mission exhibit residual systematic artifacts. VIR is an imaging spectrometer coupling high spectral and spatial resolutions in the visible and infrared spectral domain (0.25-5.0 μm). VIR data present one type of noise that may mask or distort real features (i.e., spikes and stripes), which may lead to misinterpretation of the surface composition. This paper presents a technique for the minimization of artifacts in VIR data that include a new instrument response function combining ground and in-flight radiometric measurements, correction of spectral spikes, odd-even band effects, systematic vertical stripes, high-frequency noise, and comparison with ground telescopic spectra of Vesta and Ceres. We developed a correction of artifacts in a two steps process: creation of the artifacts matrix and application of the same matrix to the VIR dataset. In the approach presented here, a polynomial function is used to fit the high frequency variations. After applying these corrections, the resulting spectra show improvements of the quality of the data. The new calibrated data enhance the significance of results from the spectral analysis of Vesta and Ceres.

Surface water monitoring in the mercury mining district of Asturias (Spain).

PubMed

Loredo, Jorge; Petit-Domínguez, María Dolores; Ordóñez, Almudena; Galán, María Pilar; Fernández-Martínez, Rodolfo; Alvarez, Rodrigo; Rucandio, María Isabel

2010-04-15

Systematic monitoring of surface waters in the area of abandoned mine sites constitutes an essential step in the characterisation of pollution from historic mine sites. The analytical data collected throughout a hydrologic period can be used for hydrological modelling and also to select appropriate preventive and/or corrective measures in order to avoid pollution of watercourses. Caudal River drains the main abandoned Hg mine sites (located in Mieres and Pola de Lena districts) in Central Asturias (NW Spain). This paper describes a systematic monitoring of physical and chemical parameters in eighteen selected sampling points within the Caudal River catchment. At each sampling station, water flow, pH, specific conductance, dissolved oxygen, salinity, temperature, redox potential and turbidity were controlled "in situ" and major and trace elements were analysed in the laboratory. In the Hg-mineralised areas, As is present in the form of As-rich pyrite, realgar and occasionally arsenopyrite. Mine drainage and leachates from spoil heaps exhibit in some cases acidic conditions and high As contents, and they are incorporated to Caudal River tributaries. Multivariate statistical analysis aids to the interpretation of the spatial and temporary variations found in the sampled areas, as part of a methodology applicable to different environmental and geological studies. 2009 Elsevier B.V. All rights reserved.

Multicompetence and Native Speaker Variation in Clausal Packaging in Japanese

ERIC Educational Resources Information Center

Brown, Amanda; Gullberg, Marianne

2012-01-01

Native speakers show systematic variation in a range of linguistic domains as a function of a variety of sociolinguistic variables. This article addresses native language variation in the context of multicompetence, i.e. knowledge of two languages in one mind (Cook, 1991). Descriptions of motion were elicited from functionally monolingual and…

A comparative analysis of temporomandibular joint morphology in the African apes.

PubMed

Taylor, Andrea B

2005-06-01

A number of researchers have suggested a functional relationship between dietary variation and temporomandibular joint (TMJ) morphology, yet few studies have evaluated TMJ form in the African apes. In this study, I compare TMJ morphology in adults and during ontogeny in Gorilla (G.g. beringei, G.g. graueri, and G.g. gorilla) and Pan (P. paniscus, P. troglodytes troglodytes, P.t. schweinfurthii, and P.t. verus). I test two hypotheses: first, compared to all other African apes, G.g. beringei exhibits TMJ morphologies that would be predicted for a primate that consumes a diet comprised primarily of moderately to very tough, leafy vegetation; and second, all gorillas exhibit the same predicted morphologies compared to Pan. Compared to all adult African apes, G.g. beringei has higher rami and condyles positioned further above the occlusal plane of the mandible, relative to jaw length. Thus, mountain gorillas have the potential to generate relatively more muscle force, more evenly distribute occlusal forces along the postcanine teeth, and generate relatively greater jaw adductor moment. G.g. beringei also exhibits relatively wider mandibular condyles, suggesting these folivorous apes are able to resist relatively greater compressive loads along the lateral and/or medial aspect of the condyle. All gorillas likewise exhibit these same shape differences compared to Pan. These morphological responses are the predicted consequences of intensification of folivory and, as such, provide support for functional hypotheses linking these TMJ morphologies to degree of folivory. The African apes to not, however, demonstrate a systematic pattern of divergence in relative condylar area as a function of intensification of folivory. The ontogenetic trajectories for gorillas are significantly elevated above those of Pan, and to a lesser but still significant degree, mountain gorillas similarly deviate from lowland gorillas (G.g. gorilla and G.g. graueri). Thus, adult shape differences in ramal and condylar heights do not result from the simple extrapolation of common growth allometries relative to jaw length. As such, they are suggestive of an adaptive shift towards a tougher, more folivorous diet. However, the allometric patterning for condylar area and condylar width does not systematically conform to predictions based on dietary specialization. Thus, while differences in condylar shapes may confer functional advantages both during growth and as adults, there is no evidence to suggest selection for altered condylar proportions, independent of the effects of changes in jaw size.

Systematic Desensitization in Group Counseling Settings: An Overview

ERIC Educational Resources Information Center

Mayton, Daniel M., II; Atkinson, Donald R.

1974-01-01

This article summarizes research on systematic desensitization applied in group settings. Guidelines for use of group desensitization by college counselors are developed, and relevant sources regarding procedural variations cited. The need for research on group desensitization parameters is discussed. (Author)

A systematic review of body temperature variations in older people.

PubMed

Lu, Shu-Hua; Leasure, Angela-Renee; Dai, Yu-Tzu

2010-01-01

The purpose of this systematic review was to determine the extent to which the research literature indicates body temperature norms in the geriatric population. The specific questions addressed were to examine normal body temperature values in persons 60 years of age and older; determine differences in temperature values depending on non-invasive measurement site and measurement device used; and, examine the degree and extent of temperature variability according to time of day and time of year. The traditional 'normal' temperature of 98.6 degrees F/37 degrees C may in fact be lower in older people due to the ageing process. Age-associated changes in vasomotor sweating function, skeletal muscle response, temperature perception and physical behaviours may influence the ability to maintain optimum temperature. A systematic literature review. A search of multiple databases yielded 22 papers which met inclusion criteria. Studies were included which focused on temperature measurement, sampled persons 60 years of age and older, collected data from non-invasive temperature measurement sites and which used a prospective study design. Studies were independently appraised using a structured appraisal format. Temperature normal values by site were rectal 98.8 degrees F/37.1 degrees C, ear-based 98.3 degrees F/36.8 degrees C, urine 97.6 degrees F/36.5 degrees C, oral 97.4 degrees F/36.3 degrees C and axillary 97.1 degrees F/36.2 degrees C. Temperature exhibited a 0.7 degrees F/0.4 degrees C diurnal and 0.2 degrees F/0.1 degrees C circannual variation. Synthesis of data indicated that normal body temperature values in older people by sites were rectal 0.7 degrees F/0.4 degrees C, ear-based 0.3 degrees F/0.2 degrees C, oral 1.2 degrees F/0.7 degrees C, axillary 0.6 degrees F/0.3 degrees C lower than adults' acceptable value from those traditionally found in nursing textbooks. Given the fact that normal body temperature values were consistently lower than values reported in the literature, clinicians may need to re-evaluate the point at which interventions for abnormal temperatures are initiated.

Prevalence of menopausal symptoms in Asian midlife women: a systematic review.

PubMed

Islam, M Rakibul; Gartoulla, P; Bell, R J; Fradkin, P; Davis, S R

2015-04-01

To systematically review published articles for the prevalence of menopausal symptoms in Asian women. A comprehensive and systematic literature search was performed using MEDLINE, EMBASE, PsycINFO, CINAHL, SCOPUS and Google scholar in June 2013 to retrieve all English-language studies that included information on the prevalence of menopausal symptoms in women living in Asian countries. Risk of bias of included studies was assessed using a risk-of-bias tool explicitly designed for the systematic review of prevalence studies. Twenty-three independent studies met our inclusion criteria. Physical symptoms were the most prevalent symptoms compared to psychological, vasomotor and sexual symptoms. There was a wide variation in the prevalence of all symptoms across the menopausal stages due to the differences in modes of recruitment, study design, sampling procedures, the time frame over which symptoms were assessed and use of different diagnostic or screening tools. A high level of bias was observed for both external and internal validity for most studies. Although there is a wide variation in the reported prevalence of menopausal symptoms, physical symptoms predominate, followed by psychological symptoms, vasomotor symptoms and sexual symptoms. Further studies of representative samples are necessary to understand whether the variations in prevalence reporting are a function of methodological issues or due to ethnic, cultural or other socioeconomic differences.

Aeolian sand transport over complex intertidal bar-trough beach topography

NASA Astrophysics Data System (ADS)

Anthony, Edward J.; Ruz, Marie-Hélène; Vanhée, Stéphane

2009-04-01

Aeolian sand transport on macrotidal beaches with complex intertidal bar-trough topography (ridge-and-runnel beaches) was assessed from experiments in northern France that involved measurements of wind speed, saltation, surface moisture contents, and rates of sand trapping across surveyed portions of the upper beach profile. Beaches exhibiting intertidal bars and troughs are much more complex, topographically, than simple reflective or dissipative beaches. Furthermore, the intertidal bar-trough morphology commonly exhibits strong cross-shore variations in the moisture contents of the beach surface and in patterns of bedform development. The results of four 30-minute experiments, conducted along topographically surveyed portions of the upper beach-dune toe profile, show that troughs act as extremely efficient sand interceptors, because of their permanently saturated state, which also inhibits sand mobilisation. Troughs, thus, limit or segment the dry fetch during conditions of intermittent saltation. Flow lines, inferred from the wind profiles, suggest that complex interactions at the boundary layer are generated by the bar-trough topography. Troughs systematically appear to be characterised by air expansion, while bar faces generate ramp wind acceleration for onshore winds, and sometimes immediate downwind deceleration for offshore winds. These effects may also contribute to cross-shore variations in the rates of sand trapping. Finally, a simple conceptual model of effective fetch development, integrating the effects of the spring-neap tidal range and of gross bar-trough morphological variability over time, is proposed for bar-trough beaches. The model highlights the key theme of fetch segmentation induced by cross-shore differentiation in the moisture contents of the beach surface hinged on the complex topography of multiple bars and troughs.

The Effect of Geographic Units of Analysis on Measuring Geographic Variation in Medical Services Utilization.

PubMed

Kim, Agnus M; Park, Jong Heon; Kang, Sungchan; Hwang, Kyosang; Lee, Taesik; Kim, Yoon

2016-07-01

We aimed to evaluate the effect of geographic units of analysis on measuring geographic variation in medical services utilization. For this purpose, we compared geographic variations in the rates of eight major procedures in administrative units (districts) and new areal units organized based on the actual health care use of the population in Korea. To compare geographic variation in geographic units of analysis, we calculated the age-sex standardized rates of eight major procedures (coronary artery bypass graft surgery, percutaneous transluminal coronary angioplasty, surgery after hip fracture, knee-replacement surgery, caesarean section, hysterectomy, computed tomography scan, and magnetic resonance imaging scan) from the National Health Insurance database in Korea for the 2013 period. Using the coefficient of variation, the extremal quotient, and the systematic component of variation, we measured geographic variation for these eight procedures in districts and new areal units. Compared with districts, new areal units showed a reduction in geographic variation. Extremal quotients and inter-decile ratios for the eight procedures were lower in new areal units. While the coefficient of variation was lower for most procedures in new areal units, the pattern of change of the systematic component of variation between districts and new areal units differed among procedures. Geographic variation in medical service utilization could vary according to the geographic unit of analysis. To determine how geographic characteristics such as population size and number of geographic units affect geographic variation, further studies are needed.

Interobserver delineation variation in lung tumour stereotactic body radiotherapy

PubMed Central

Persson, G F; Nygaard, D E; Hollensen, C; Munck af Rosenschöld, P; Mouritsen, L S; Due, A K; Berthelsen, A K; Nyman, J; Markova, E; Roed, A P; Roed, H; Korreman, S; Specht, L

2012-01-01

Objectives In radiotherapy, delineation uncertainties are important as they contribute to systematic errors and can lead to geographical miss of the target. For margin computation, standard deviations (SDs) of all uncertainties must be included as SDs. The aim of this study was to quantify the interobserver delineation variation for stereotactic body radiotherapy (SBRT) of peripheral lung tumours using a cross-sectional study design. Methods 22 consecutive patients with 26 tumours were included. Positron emission tomography/CT scans were acquired for planning of SBRT. Three oncologists and three radiologists independently delineated the gross tumour volume. The interobserver variation was calculated as a mean of multiple SDs of distances to a reference contour, and calculated for the transversal plane (SDtrans) and craniocaudal (CC) direction (SDcc) separately. Concordance indexes and volume deviations were also calculated. Results Median tumour volume was 13.0 cm3, ranging from 0.3 to 60.4 cm3. The mean SDtrans was 0.15 cm (SD 0.08 cm) and the overall mean SDcc was 0.26 cm (SD 0.15 cm). Tumours with pleural contact had a significantly larger SDtrans than tumours surrounded by lung tissue. Conclusions The interobserver delineation variation was very small in this systematic cross-sectional analysis, although significantly larger in the CC direction than in the transversal plane, stressing that anisotropic margins should be applied. This study is the first to make a systematic cross-sectional analysis of delineation variation for peripheral lung tumours referred for SBRT, establishing the evidence that interobserver variation is very small for these tumours. PMID:22919015

Endogenous sources of variation in language acquisition.

PubMed

Han, Chung-Hye; Musolino, Julien; Lidz, Jeffrey

2016-01-26

A fundamental question in the study of human language acquisition centers around apportioning explanatory force between the experience of the learner and the core knowledge that allows learners to represent that experience. We provide a previously unidentified kind of data identifying children's contribution to language acquisition. We identify one aspect of grammar that varies unpredictably across a population of speakers of what is ostensibly a single language. We further demonstrate that the grammatical knowledge of parents and their children is independent. The combination of unpredictable variation and parent-child independence suggests that the relevant structural feature is supplied by each learner independent of experience with the language. This structural feature is abstract because it controls variation in more than one construction. The particular case we examine is the position of the verb in the clause structure of Korean. Because Korean is a head-final language, evidence for the syntactic position of the verb is both rare and indirect. We show that (i) Korean speakers exhibit substantial variability regarding this aspect of the grammar, (ii) this variability is attested between speakers but not within a speaker, (iii) this variability controls interpretation in two surface constructions, and (iv) it is independent in parents and children. According to our findings, when the exposure language is compatible with multiple grammars, learners acquire a single systematic grammar. Our observation that children and their parents vary independently suggests that the choice of grammar is driven in part by a process operating internal to individual learners.

Study of morphological variation of northern Neotropical Ariidae reveals conservatism despite macrohabitat transitions.

PubMed

Stange, Madlen; Aguirre-Fernández, Gabriel; Salzburger, Walter; Sánchez-Villagra, Marcelo R

2018-03-27

Morphological convergence triggered by trophic adaptations is a common pattern in adaptive radiations. The study of shape variation in an evolutionary context is usually restricted to well-studied fish models. We take advantage of the recently revised systematics of New World Ariidae and investigate skull shape evolution in six genera of northern Neotropical Ariidae. They constitute a lineage that diversified in the marine habitat but repeatedly adapted to freshwater habitats. 3D geometric morphometrics was applied for the first time in catfish skulls and phylogenetically informed statistical analyses were performed to test for the impact of habitat on skull diversification after habitat transition in this lineage. We found that skull shape is conserved throughout phylogeny. A morphospace analysis revealed that freshwater and marine species occupy extreme ends of the first principal component axis and that they exhibit similar Procrustes variances. Yet freshwater species occupy the smallest shape space compared to marine and brackish species (based on partial disparity), and marine and freshwater species have the largest Procrustes distance to each other. We observed a single case of shape convergence as derived from 'C-metrics', which cannot be explained by the occupation of the same habitat. Although Ariidae occupy such a broad spectrum of different habitats from sea to freshwater, the morphospace analysis and analyses of shape and co-variation with habitat in a phylogenetic context shows that conservatism dominates skull shape evolution among ariid genera.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Singh, Rajesh K.; Galvin, Janine E.; Sun, Xin

We have numerically investigated the breakup of a rivulet falling over a smooth inclined plate using the volume of fluid method. The breakup the rivulet is a complex phenomenon that is dictated by many factors, such as solvent properties, contact angle, inertia, plate inclination, etc. An extensive simulation campaign was conducted wherein these factors were systematically investigated. Regimes for a stable rivulet and an unstable rivulet that leads to the breakup and formation of a droplet are examined in terms of a critical value of the Weber number (Wecr) that delineates these regimes. The effect of plate inclination on themore » breakup of the rivulet shows that the critical Weber number decreases with increased inclination angle () owing to higher liquid velocity. However, the effect is negligible beyond >60. The impact of solvent properties is characterized using the Kapitza number (Ka). Variation of Wecr with Ka shows two trends depending on the Ka value of the solvent. Solvents with lower Ka values, corresponding to high viscosities and/or low surface tensions, show smaller values of the critical Weber number and the variation is linear. While solvents with higher Ka values exhibit higher values of the Wecr and the variation in Wecr is steep. This behavior is more pronounced with increasing contact angle. Higher contact angles promote rivulet breakup so that inertia must be higher to the breakup. A phenomenological scaling for a critical Weber number with the Kapitza number and contact angle is presented that can offer insight into rivulet breakup.« less

Genetic differentiation among populations of marine algae

NASA Astrophysics Data System (ADS)

Innes, D. J.

1984-09-01

Most of the information for genetic differentiation among populations of marine algae is from studies on ecotypic variation. Physiological ecotypes have been described for individuals showing different responses to temperature and salinity conditions. Morphological ecotypes have also been found associated with areas differing in wave exposure or different intertidal positions. Little is known on how genetic variation is organized within and between populations of marine algae. The occurrence of ecotypic variation in some species is evidence for genetic differentiation among populations resulting from selection by the local environment. The rate of dispersal and subsequent gene flow will also affect the level of differentiation among populations. In species with low dispersal, differentiation can arise through chance founder events or random genetic drift. The few studies available have shown that species of algae exhibit a range of dispersal capabilities. This information can be useful for predicting the potential level of genetic differentiation among populations of these species. Crossing experiments with several species of algae have shown that populations separated by a considerable distance can be interfertile. In some cases individuals from these populations have been found to be morphologically distinct. Crosses have been used to study the genetic basis of this variation and are evidence for genetic differentiation among the populations sampled. Genetic variation of enzyme proteins detected by electrophoresis provides an additional method for measuring genetic variation within and between populations of marine algae. Electrophoretic methods have previously been used to study systematic problems in algae. However, there have been few attempts to use electrophoretic variation to study the genetic structure of populations of marine algae. This approach is outlined and includes some of the potential problems associated with interpreting electrophoretic data. Studies of electrophoretic variation in natural populations of Enteromorpha linza from Long island Sound are used as an example. This species was found to reproduce only asexually. Despite a dispersing spore stage, genetic differentiation was found on a microgeographic scale and was correlated with differences in the local environment of some of the populations. Similar studies on other species, and especially sexually reproducing species, will add to a growing understanding of the evolutionary genetics of marine algae.

Acquiring variation in an artificial language: Children and adults are sensitive to socially conditioned linguistic variation.

PubMed

Samara, Anna; Smith, Kenny; Brown, Helen; Wonnacott, Elizabeth

2017-05-01

Languages exhibit sociolinguistic variation, such that adult native speakers condition the usage of linguistic variants on social context, gender, and ethnicity, among other cues. While the existence of this kind of socially conditioned variation is well-established, less is known about how it is acquired. Studies of naturalistic language use by children provide various examples where children's production of sociolinguistic variants appears to be conditioned on similar factors to adults' production, but it is difficult to determine whether this reflects knowledge of sociolinguistic conditioning or systematic differences in the input to children from different social groups. Furthermore, artificial language learning experiments have shown that children have a tendency to eliminate variation, a process which could potentially work against their acquisition of sociolinguistic variation. The current study used a semi-artificial language learning paradigm to investigate learning of the sociolinguistic cue of speaker identity in 6-year-olds and adults. Participants were trained and tested on an artificial language where nouns were obligatorily followed by one of two meaningless particles and were produced by one of two speakers (one male, one female). Particle usage was conditioned deterministically on speaker identity (Experiment 1), probabilistically (Experiment 2), or not at all (Experiment 3). Participants were given tests of production and comprehension. In Experiments 1 and 2, both children and adults successfully acquired the speaker identity cue, although the effect was stronger for adults and in Experiment 1. In addition, in all three experiments, there was evidence of regularization in participants' productions, although the type of regularization differed with age: children showed regularization by boosting the frequency of one particle at the expense of the other, while adults regularized by conditioning particle usage on lexical items. Overall, results demonstrate that children and adults are sensitive to speaker identity cues, an ability which is fundamental to tracking sociolinguistic variation, and that children's well-established tendency to regularize does not prevent them from learning sociolinguistically conditioned variation. Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.

Infants Are Sensitive to Within-Category Variation in Speech Perception

ERIC Educational Resources Information Center

McMurray, Bob; Aslin, Richard N.

2005-01-01

Previous research on speech perception in both adults and infants has supported the view that consonants are perceived categorically; that is, listeners are relatively insensitive to variation below the level of the phoneme. More recent work, on the other hand, has shown adults to be systematically sensitive to within category variation [McMurray,…

Development of clinical process measures for pediatric burn care: Understanding variation in practice patterns.

PubMed

Kazis, Lewis E; Sheridan, Robert L; Shapiro, Gabriel D; Lee, Austin F; Liang, Matthew H; Ryan, Colleen M; Schneider, Jeffrey C; Lydon, Martha; Soley-Bori, Marina; Sonis, Lily A; Dore, Emily C; Palmieri, Tina; Herndon, David; Meyer, Walter; Warner, Petra; Kagan, Richard; Stoddard, Frederick J; Murphy, Michael; Tompkins, Ronald G

2018-04-01

There has been little systematic examination of variation in pediatric burn care clinical practices and its effect on outcomes. As a first step, current clinical care processes need to be operationally defined. The highly specialized burn care units of the Shriners Hospitals for Children system present an opportunity to describe the processes of care. The aim of this study was to develop a set of process-based measures for pediatric burn care and examine adherence to them by providers in a cohort of pediatric burn patients. We conducted a systematic literature review to compile a set of process-based indicators. These measures were refined by an expert panel of burn care providers, yielding 36 process-based indicators in four clinical areas: initial evaluation and resuscitation, acute excisional surgery and critical care, psychosocial and pain control, and reconstruction and aftercare. We assessed variability in adherence to the indicators in a cohort of 1,076 children with burns at four regional pediatric burn programs in the Shriners Hospital system. The percentages of the cohort at each of the four sites were as follows: Boston, 20.8%; Cincinnati, 21.1%; Galveston, 36.0%; and Sacramento, 22.1%. The cohort included children who received care between 2006 and 2010. Adherence to the process indicators varied both across sites and by clinical area. Adherence was lowest for the clinical areas of acute excisional surgery and critical care, with a range of 35% to 48% across sites, followed by initial evaluation and resuscitation (range, 34%-60%). In contrast, the clinical areas of psychosocial and pain control and reconstruction and aftercare had relatively high adherence across sites, with ranges of 62% to 93% and 71% to 87%, respectively. Of the 36 process indicators, 89% differed significantly in adherence between clinical sites (p < 0.05). Acute excisional surgery and critical care exhibited the most variability. The development of this set of process-based measures represents an important step in the assessment of clinical practice in pediatric burn care. Substantial variation was observed in practices of pediatric burn care. However, further research is needed to link these process-based measures to clinical outcomes. Therapeutic/care management, level IV.

Worldwide Impact of Warmer Seasons on the Incidence of Renal Colic and Kidney Stone Disease: Evidence from a Systematic Review of Literature.

PubMed

Geraghty, Robert M; Proietti, Silvia; Traxer, Olivier; Archer, Matthew; Somani, Bhaskar K

2017-08-01

Several studies have examined the link between temperature or monthly seasonal variations and urolithiasis. The majority of these studies have demonstrated a link between higher ambient monthly temperatures and the incidence of renal colic and kidney stone disease (KSD). However, a worldwide trend on this association has not been explored and we perform a systematic review to examine the effect of seasonal variations on renal colic and KSD. A systematic review of the literature for a 26-year period (1990-2017) was conducted on all studies reporting on the effect of seasonal variations and its link to KSD. Two reviewers independently extracted the data from each study, which were analyzed using SPSS version 24. A total of 59 studies were identified, and after screening, 13 were included in this review. The studies ranged in duration from 1 to 9 years (mean: 5.5 years) and included seasonal/monthly variations for proven stones or lithotripsy treatments or emergency department presentations with renal colic. Except for one study, there was a statistically significant association between higher monthly mean temperatures and the incidence of KSD-related events reported from the United Kingdom, South Korea, the United States, Saudi Arabia, Italy, Spain, Taiwan, Japan, and New Zealand. Worldwide trends on the incidence of renal colic and KSD seem be affected by seasonal variation favoring warmer months, with data suggesting that higher ambient temperature has an association with KSD.

Student Service Members/Veterans in Higher Education: A Systematic Review

ERIC Educational Resources Information Center

Barry, Adam E.; Whiteman, Shawn D.; MacDermid Wadsworth, Shelley

2014-01-01

We systematically reviewed the data-based peer-reviewed research examining student service members/veterans (SSM/V) in higher education. Compared to civilian peers, SSM/V exhibit disproportionately higher rates of health risk behaviors and psychological symptoms, and personal and educational adjustment difficulties (i.e., inability to connect with…

Magnetic properties of Co2Fe(Ga1-xSix) alloys

NASA Astrophysics Data System (ADS)

Deka, Bhargab; Chakraborty, Dibyashree; Srinivasan, Ananthakrishnan

2014-09-01

Magnetic and crystallographic properties of bulk Co2Fe(Ga1-xSix) alloys with 0≤x≤1 are reported in this work. The alloys with x=0.75 and 1.00 exhibit L21 structure whereas the alloys with x=0, 0.25 and 0.50 crystallized in the disordered A2 phase. Unit cell volume of this series of alloys decreased from 189.1 to 178.5 Å3 as x was increased from 0 to 1.00. All alloy compositions exhibit ferromagnetic behavior with a high Curie temperature (TC) which showed a systematic variation with x (1089 K, 1075 K, 1059 K, 1019 K and 1015 K for x=0, 0.25, 0.5, 0.75 and 1.00, respectively). The saturation magnetization moment Ms for the alloys with x=0, 0.25 and 0.50 are 5.05μB, 5.23μB, 5.49μB, respectively, in accordance with the Slater-Pauling rule, but alloys with x=0.75 and 1.00 deviated from this rule. The effective moment per magnetic atom (pc) of the alloys was estimated from the inverse DC magnetic susceptibility data above TC. A comparison of Ms with pc reveals the half-metallic character of the alloys.

Genome-Wide Fine-Scale Recombination Rate Variation in Drosophila melanogaster

PubMed Central

Song, Yun S.

2012-01-01

Estimating fine-scale recombination maps of Drosophila from population genomic data is a challenging problem, in particular because of the high background recombination rate. In this paper, a new computational method is developed to address this challenge. Through an extensive simulation study, it is demonstrated that the method allows more accurate inference, and exhibits greater robustness to the effects of natural selection and noise, compared to a well-used previous method developed for studying fine-scale recombination rate variation in the human genome. As an application, a genome-wide analysis of genetic variation data is performed for two Drosophila melanogaster populations, one from North America (Raleigh, USA) and the other from Africa (Gikongoro, Rwanda). It is shown that fine-scale recombination rate variation is widespread throughout the D. melanogaster genome, across all chromosomes and in both populations. At the fine-scale, a conservative, systematic search for evidence of recombination hotspots suggests the existence of a handful of putative hotspots each with at least a tenfold increase in intensity over the background rate. A wavelet analysis is carried out to compare the estimated recombination maps in the two populations and to quantify the extent to which recombination rates are conserved. In general, similarity is observed at very broad scales, but substantial differences are seen at fine scales. The average recombination rate of the X chromosome appears to be higher than that of the autosomes in both populations, and this pattern is much more pronounced in the African population than the North American population. The correlation between various genomic features—including recombination rates, diversity, divergence, GC content, gene content, and sequence quality—is examined using the wavelet analysis, and it is shown that the most notable difference between D. melanogaster and humans is in the correlation between recombination and diversity. PMID:23284288

Chemical evidence for differentiation, evaporation and recondensation from silicate clasts in Gujba

NASA Astrophysics Data System (ADS)

Oulton, Jonathan; Humayun, Munir; Fedkin, Alexei; Grossman, Lawrence

2016-03-01

The silicate and metal clasts in CB chondrites have been inferred to form as condensates from an impact-generated vapor plume between a metal-rich body and a silicate body. A detailed study of the condensation of impact-generated vapor plumes showed that the range of CB silicate clast compositions could not be successfully explained without invoking a chemically differentiated target. Here, we report the most comprehensive elemental study yet performed on CB silicates with 32 silicate clasts from nine slices of Gujba analyzed by laser ablation inductively coupled plasma mass spectrometry for 53 elements. Like in other studies of CBs, the silicate clasts are either barred olivine (BO) or cryptocrystalline (CC) in texture. In major elements, the Gujba silicate clasts ranged from chondritic to refractory enriched. Refractory element abundances ranged from 2 to 10 × CI, with notable anomalies in Ba, Ce, Eu, and U abundances. The two most refractory-enriched BO clasts exhibited negative Ce anomalies and were depleted in U relative to Th, characteristic of volatilization residues, while other BO clasts and the CC clasts exhibited positive Ce anomalies with excess U (1-3 × CI), and Ba (1-6 × CI) anomalies indicating re-condensation of ultra-refractory element depleted vapor. The Rare Earth Elements (REE) also exhibit light REE (LREE) enrichment or depletion in several clasts with a range of (La/Sm)CI of 0.9-1.8. This variation in the LREE is essentially impossible to accomplish by processes involving vapor-liquid or vapor-solid exchange of REE, and appears to have been inherited from a differentiated target. The most distinctive evidence for inherited chemical differentiation is observed in highly refractory element (Sc, Zr, Nb, Hf, Ta, Th) systematics. The Gujba clasts exhibit fractionations in Nb/Ta that correlate positively with Zr/Hf and span the range known from lunar and Martian basalts, and exceed the range in Zr/Hf variation known from eucrites. Variations of highly incompatible refractory elements (e.g., Th) against less incompatible elements (e.g., Zr, Sr, Sc) are not chondritic, but exhibit distinctly higher Th abundances requiring a differentiated crust to be admixed with depleted mantle in ratios that are biased to higher crust/mantle ratios than in a chondritic body. The possibility that these variations are due to admixture of refractory inclusion-debris into normal chondritic matter is raised but cannot be definitively tested because existing ;bulk; analyses of CAIs carry artifacts of unrepresentative sampling. The inferences drawn from the compositions of Gujba silicate clasts, here, complement what has been inferred from the compositions of metallic clasts, but provide surprisingly detailed insight into the structure of the target. Evidence that metal and silicate in CB chondrites both formed from impact-generated vapor plumes, taken together with recent work on metallic nodules in E chondrites, and on ordinary chondrites, indicates that chondrule formation occurs by this mechanism quite widely. However, the nature of the impact on the CB body is quite different than the popular conceptions of impact of partially or wholly molten chondritic bodies and the younger (5 Ma) age of CB chondrules is consistent with origin in a disk with more evolved targets and impactors gravitationally perturbed by nascent planets.

Self-compensating design for reduction of timing and leakage sensitivity to systematic pattern dependent variation

NASA Astrophysics Data System (ADS)

Gupta, Puneet; Kahng, Andrew B.; Kim, Youngmin; Sylvester, Dennis

2006-03-01

Focus is one of the major sources of linewidth variation. CD variation caused by defocus is largely systematic after the layout is finished. In particular, dense lines "smile" through focus while isolated lines "frown" in typical Bossung plots. This well-defined systematic behavior of focus-dependent CD variation allows us to develop a self-compensating design methodology. In this work, we propose a novel design methodology that allows explicit compensation of focus-dependent CD variation, either within a cell (self-compensated cells) or across cells in a critical path (self-compensated design). By creating iso and dense variants for each library cell, we can achieve designs that are more robust to focus variation. Optimization with a mixture of iso and dense cell variants is possible both for area and leakage power, with the latter providing an interesting complement to existing leakage reduction techniques such as dual-Vth. We implement both heuristic and Mixed-Integer Linear Programming (MILP) solution methods to address this optimization, and experimentally compare their results. Our results indicate that designing with a self-compensated cell library incurs ~12% area penalty and ~6% leakage increase over original layouts while compensating for focus-dependent CD variation (i.e., the design meets timing constraints across a large range of focus variation). We observe ~27% area penalty and ~7% leakage increase at the worst-case defocus condition using only single-pitch cells. The area penalty of circuits after using either the heuristic or MILP optimization approach is reduced to ~3% while maintaining timing. We also apply our optimizations to leakage, which traditionally shows very large variability due to its exponential relationship with gate CD. We conclude that a mixed iso/dense library combined with a sensitivity-based optimization approach yields much better area/timing/leakage tradeoffs than using a self-compensated cell library alone. Self-compensated design shows an average of 25% leakage reduction at the worst defocus condition for the benchmark designs that we have studied.

Variation in the myosoricine hand skeleton and its implications for locomotory behavior (Eulipotyphla: Soricidae)

USGS Publications Warehouse

Woodman, Neal; Stabile, Frank A.

2015-01-01

Substrate use and locomotory behavior of mammals are typically reflected in external characteristics of the forefeet, such as the relative proportions of the digits and claws. Although skeletal anatomy of the forefeet can be more informative than external characters, skeletons remain rare in systematic collections. This is particularly true for the Myosoricinae (Eulipotyphla: Soricidae), a small clade of African shrews that includes both ambulatory forest shrews (Myosorex) and semifossorial mole shrews (Surdisorex). Most species in this subfamily have restricted distributions, and their behavior and ecology are mostly unstudied. To better understand the potential range of locomotory behavior among myosoricines, we used digital x-rays to image and facilitate measuring the forefoot skeletons of 9 species. As a gauge of potential variation, we compared them with the ambulatory talpid Uropsilus (Talpidae) and the semifossorial talpid Neurotrichus. The hand morphologies of myosoricines show a graded range of potential substrate use between ambulatory and semifossorial. Some of these shrews exhibit adaptations for increased burrowing efficiency that are similar to those seen in talpids and other mammals, such as longer, broader distal phalanges and claws and shorter, wider metacarpals and proximal and middle phalanges. They also, however, have characteristics that are distinct from talpids, such as maintenance of forefoot asymmetry and an increased emphasis of ray III.

Kepler eclipsing binary stars. IV. Precise eclipse times for close binaries and identification of candidate three-body systems

DOE Office of Scientific and Technical Information (OSTI.GOV)

Conroy, Kyle E.; Stassun, Keivan G.; Prša, Andrej

2014-02-01

We present a catalog of precise eclipse times and analysis of third-body signals among 1279 close binaries in the latest Kepler Eclipsing Binary Catalog. For these short-period binaries, Kepler's 30 minute exposure time causes significant smearing of light curves. In addition, common astrophysical phenomena such as chromospheric activity, as well as imperfections in the light curve detrending process, can create systematic artifacts that may produce fictitious signals in the eclipse timings. We present a method to measure precise eclipse times in the presence of distorted light curves, such as in contact and near-contact binaries which exhibit continuously changing light levelsmore » in and out of eclipse. We identify 236 systems for which we find a timing variation signal compatible with the presence of a third body. These are modeled for the light travel time effect and the basic properties of the third body are derived. This study complements J. A. Orosz et al. (in preparation), which focuses on eclipse timing variations of longer period binaries with flat out-of-eclipse regions. Together, these two papers provide comprehensive eclipse timings for all binaries in the Kepler Eclipsing Binary Catalog, as an ongoing resource freely accessible online to the community.« less

Evolutionary rates for multivariate traits: the role of selection and genetic variation.

PubMed

Pitchers, William; Wolf, Jason B; Tregenza, Tom; Hunt, John; Dworkin, Ian

2014-08-19

A fundamental question in evolutionary biology is the relative importance of selection and genetic architecture in determining evolutionary rates. Adaptive evolution can be described by the multivariate breeders' equation (Δz(-)=Gβ), which predicts evolutionary change for a suite of phenotypic traits (Δz(-)) as a product of directional selection acting on them (β) and the genetic variance-covariance matrix for those traits (G ). Despite being empirically challenging to estimate, there are enough published estimates of G and β to allow for synthesis of general patterns across species. We use published estimates to test the hypotheses that there are systematic differences in the rate of evolution among trait types, and that these differences are, in part, due to genetic architecture. We find some evidence that sexually selected traits exhibit faster rates of evolution compared with life-history or morphological traits. This difference does not appear to be related to stronger selection on sexually selected traits. Using numerous proposed approaches to quantifying the shape, size and structure of G, we examine how these parameters relate to one another, and how they vary among taxonomic and trait groupings. Despite considerable variation, they do not explain the observed differences in evolutionary rates. © 2014 The Author(s) Published by the Royal Society. All rights reserved.

The substorm loading-unloading cycle as reproduced by community-available global MHD magnetospheric models

NASA Astrophysics Data System (ADS)

Gordeev, Evgeny; Sergeev, Victor; Tsyganenko, Nikolay; Kuznetsova, Maria; Rastaetter, Lutz; Raeder, Joachim; Toth, Gabor; Lyon, John; Merkin, Vyacheslav; Wiltberger, Michael

2017-04-01

In this study we investigate how well the three community-available global MHD models, supported by the Community Coordinated Modeling Center (CCMC NASA), reproduce the global magnetospheric dynamics, including the loading-unloading substorm cycle. We found that in terms of global magnetic flux transport CCMC models display systematically different response to idealized 2-hour north then 2-hour south IMF Bz variation. The LFM model shows a depressed return convection in the tail plasma sheet and high rate of magnetic flux loading into the lobes during the growth phase, as well as enhanced return convection and high unloading rate during the expansion phase, with the amount of loaded/unloaded magnetotail flux and the growth phase duration being the closest to their observed empirical values during isolated substorms. BATSRUS and Open GGCM models exhibit drastically different behavior. In the BATS-R-US model the plasma sheet convection shows a smooth transition to the steady convection regime after the IMF southward turning. In the Open GGCM a weak plasma sheet convection has comparable intensities during both the growth phase and the following slow unloading phase. Our study shows that different CCMC models under the same solar wind conditions (north to south IMF variation) produce essentially different solutions in terms of global magnetospheric convection.

Quantitative historical analysis uncovers a single dimension of complexity that structures global variation in human social organization.

PubMed

Turchin, Peter; Currie, Thomas E; Whitehouse, Harvey; François, Pieter; Feeney, Kevin; Mullins, Daniel; Hoyer, Daniel; Collins, Christina; Grohmann, Stephanie; Savage, Patrick; Mendel-Gleason, Gavin; Turner, Edward; Dupeyron, Agathe; Cioni, Enrico; Reddish, Jenny; Levine, Jill; Jordan, Greine; Brandl, Eva; Williams, Alice; Cesaretti, Rudolf; Krueger, Marta; Ceccarelli, Alessandro; Figliulo-Rosswurm, Joe; Tuan, Po-Ju; Peregrine, Peter; Marciniak, Arkadiusz; Preiser-Kapeller, Johannes; Kradin, Nikolay; Korotayev, Andrey; Palmisano, Alessio; Baker, David; Bidmead, Julye; Bol, Peter; Christian, David; Cook, Connie; Covey, Alan; Feinman, Gary; Júlíusson, Árni Daníel; Kristinsson, Axel; Miksic, John; Mostern, Ruth; Petrie, Cameron; Rudiak-Gould, Peter; Ter Haar, Barend; Wallace, Vesna; Mair, Victor; Xie, Liye; Baines, John; Bridges, Elizabeth; Manning, Joseph; Lockhart, Bruce; Bogaard, Amy; Spencer, Charles

2018-01-09

Do human societies from around the world exhibit similarities in the way that they are structured, and show commonalities in the ways that they have evolved? These are long-standing questions that have proven difficult to answer. To test between competing hypotheses, we constructed a massive repository of historical and archaeological information known as "Seshat: Global History Databank." We systematically coded data on 414 societies from 30 regions around the world spanning the last 10,000 years. We were able to capture information on 51 variables reflecting nine characteristics of human societies, such as social scale, economy, features of governance, and information systems. Our analyses revealed that these different characteristics show strong relationships with each other and that a single principal component captures around three-quarters of the observed variation. Furthermore, we found that different characteristics of social complexity are highly predictable across different world regions. These results suggest that key aspects of social organization are functionally related and do indeed coevolve in predictable ways. Our findings highlight the power of the sciences and humanities working together to rigorously test hypotheses about general rules that may have shaped human history. Copyright © 2018 the Author(s). Published by PNAS.

Comparison of BiLinearly Interpolated Subpixel Sensitivity Mapping and Pixel-Level Decorrelation

NASA Astrophysics Data System (ADS)

Challener, Ryan C.; Harrington, Joseph; Cubillos, Patricio; Foster, Andrew S.; Deming, Drake; WASP Consortium

2016-10-01

Exoplanet eclipse signals are weaker than the systematics present in the Spitzer Space Telescope's Infrared Array Camera (IRAC), and thus the correction method can significantly impact a measurement. BiLinearly Interpolated Subpixel Sensitivity (BLISS) mapping calculates the sensitivity of the detector on a subpixel grid and corrects the photometry for any sensitivity variations. Pixel-Level Decorrelation (PLD) removes the sensitivity variations by considering the relative intensities of the pixels around the source. We applied both methods to WASP-29b, a Saturn-sized planet with a mass of 0.24 ± 0.02 Jupiter masses and a radius of 0.84 ± 0.06 Jupiter radii, which we observed during eclipse twice with the 3.6 µm and once with the 4.5 µm channels of IRAC aboard Spitzer in 2010 and 2011 (programs 60003 and 70084, respectively). We compared the results of BLISS and PLD, and comment on each method's ability to remove time-correlated noise. WASP-29b exhibits a strong detection at 3.6 µm and no detection at 4.5 µm. Spitzer is operated by the Jet Propulsion Laboratory, California Institute of Technology, under a contract with NASA. This work was supported by NASA Planetary Atmospheres grant NNX12AI69G and NASA Astrophysics Data Analysis Program grant NNX13AF38G.

Photonic states mixing beyond the plasmon hybridization model

DOE Office of Scientific and Technical Information (OSTI.GOV)

Suryadharma, Radius N. S.; Iskandar, Alexander A., E-mail: iskandar@fi.itb.ac.id; Tjia, May-On

2016-07-28

A study is performed on a photonic-state mixing-pattern in an insulator-metal-insulator cylindrical silver nanoshell and its rich variations induced by changes in the geometry and dielectric media of the system, representing the combined influences of plasmon coupling strength and cavity effects. This study is performed in terms of the photonic local density of states (LDOS) calculated using the Green tensor method, in order to elucidate those combined effects. The energy profiles of LDOS inside the dielectric core are shown to exhibit consistently growing number of redshifted photonic states due to an enhanced plasmon coupling induced state mixing arising from decreasedmore » shell thickness, increased cavity size effect, and larger symmetry breaking effect induced by increased permittivity difference between the core and the background media. Further, an increase in cavity size leads to increased additional peaks that spread out toward the lower energy regime. A systematic analysis of those variations for a silver nanoshell with a fixed inner radius in vacuum background reveals a certain pattern of those growing number of redshifted states with an analytic expression for the corresponding energy downshifts, signifying a photonic state mixing scheme beyond the commonly adopted plasmon hybridization scheme. Finally, a remarkable correlation is demonstrated between the LDOS energy profiles outside the shell and the corresponding scattering efficiencies.« less

A Review of Dendroctonus frontalis Zimmermann Systematics

Treesearch

Anthony I. Cognato

2011-01-01

The systematic history of the southern pine beetle, Dendroctonus frontalis Zimmermann, is reviewed. Morphological, biological, karyological, and molecular data clearly define and diagnose the species limits of D. frontalis. More complete phylogenetic analysis and characterization of population genetic variation will further clarify the evolutionary history of the D....

WE-AB-207B-03: A Computational Methodology for Determination of CTV-To-PTV Margins with Inter Fractional Shape Variations Based On a Statistical Point Distribution Model for Prostate Cancer Radiation Therapy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shibayama, Y; Umezu, Y; Nakamura, Y

2016-06-15

Purpose: Our assumption was that interfractional shape variations of target volumes could not be negligible for determination of clinical target volume (CTV)-to-planning target volume (PTV) margins. The aim of this study was to investigate this assumption as a simulation study by developing a computational framework of CTV-to-PTV margins with taking the interfractional shape variations into account based on point distribution model (PDM) Methods: The systematic and random errors for interfractional shape variations and translations of target volumes were evaluated for four types of CTV regions (only a prostate, a prostate plus proximal 1-cm seminal vesicles, a prostate plus proximal 2-cmmore » seminal vesicles, and a prostate plus whole seminal vesicles). The CTV regions were delineated depending on prostate cancer risk groups on planning computed tomography (CT) and cone beam CT (CBCT) images of 73 fractions of 10 patients. The random and systematic errors for shape variations of CTV regions were derived from PDMs of CTV surfaces for all fractions of each patient. Systematic errors of shape variations of CTV regions were derived by comparing PDMs between planning CTV surfaces and average CTV surfaces. Finally, anisotropic CTV-to-PTV margins with shape variations in 6 directions (anterior, posterior, superior, inferior, right, and left) were computed by using a van Herk margin formula. Results: Differences between CTV-to-PTV margins with and without shape variations ranged from 0.7 to 1.7 mm in anterior direction, 1.0 to 2.8 mm in posterior direction, 0.8 to 2.8 mm in superior direction, 0.6 to 1.6 mm in inferior direction, 1.4 to 4.4 mm in right direction, and 1.3 to 5.2 mm in left direction. Conclusion: More than 1.0 mm additional margins were needed at least in 3 directions to guarantee CTV coverage due to shape variations. Therefore, shape variations should be taken into account for the determination of CTV-to-PTV margins.« less

Land surface phenology as a coarse-filter indicator of disturbance and climatic effects across the coast redwood range

Treesearch

Steven P. Norman; William W. Hargrove

2012-01-01

Satellite-based measurements provide a systematic measure of the seasonal fluctuations and general condition of forest vegetation, including that of the coast redwood region. Year-toyear variation in greenness may be caused by gradual disturbances, successional recovery or climatic variation, while within-year variation reflects disturbance events and the response of...

The prevalence of stillbirths: a systematic review

PubMed Central

Say, Lale; Donner, Allan; Gülmezoglu, A Metin; Taljaard, Monica; Piaggio, Gilda

2006-01-01

Background Stillbirth rate is an important indicator of access to and quality of antenatal and delivery care. Obtaining overall estimates across various regions of the world is not straightforward due to variation in definitions, data collection methods and reporting. Methods We conducted a systematic review of a range of pregnancy-related conditions including stillbirths and performed meta-analysis of the subset of studies reporting stillbirth rates. We examined variation across rates and used meta-regression techniques to explain observed variation. Results We identified 389 articles on stillbirth prevalence among the 2580 included in the systematic review. We included 70 providing 80 data sets from 50 countries in the meta-analysis. Pooled prevalence rates show variation across various subgroup categories. Rates per 100 births are higher in studies conducted in less developed country settings as compared to more developed (1.17 versus 0.50), of inadequate quality as compared to adequate (1.12 versus 0.66), using sub-national sample as compared to national (1.38 versus 0.68), reporting all stillbirths as compared to late stillbirths (0.95 versus 0.63), published in non-English as compared to English (0.91 versus 0.59) and as journal articles as compared to non-journal (1.37 versus 0.67). The results of the meta-regression show the significance of two predictor variables – development status of the setting and study quality – on stillbirth prevalence. Conclusion Stillbirth prevalence at the community level is typically less than 1% in more developed parts of the world and could exceed 3% in less developed regions. Regular reviews of stillbirth rates in appropriately designed and reported studies are useful in monitoring the adequacy of care. Systematic reviews of prevalence studies are helpful in explaining sources of variation across rates. Exploring these methodological issues will lead to improved standards for assessing the burden of reproductive ill-health. PMID:16401351

Variations in outcomes by residential location for women with breast cancer: a systematic review

PubMed Central

Dasgupta, Paramita; Youlden, Danny R; Garvey, Gail; Aitken, Joanne F; Wallington, Isabella; Chynoweth, Jennifer; Zorbas, Helen; Youl, Philippa H

2018-01-01

Objectives To systematically assess the evidence for variations in outcomes at each step along the breast cancer continuum of care for Australian women by residential location. Design Systematic review. Methods Systematic searches of peer-reviewed articles in English published from 1 January 1990 to 24 November 2017 using PubMed, EMBASE, CINAHL and Informit databases. Inclusion criteria were: population was adult female patients with breast cancer; Australian setting; outcome measure was survival, patient or tumour characteristics, screening rates or frequencies, clinical management, patterns of initial care or post-treatment follow-up with analysis by residential location or studies involving non-metropolitan women only. Included studies were critically appraised using a modified Newcastle–Ottawa Scale. Results Seventy-four quantitative studies met the inclusion criteria. Around 59% were considered high quality, 34% moderate and 7% low. No eligible studies examining treatment choices or post-treatment follow-up were identified. Non-metropolitan women consistently had poorer survival, with most of this differential being attributed to more advanced disease at diagnosis, treatment-related factors and socioeconomic disadvantage. Compared with metropolitan women, non-metropolitan women were more likely to live in disadvantaged areas and had differing clinical management and patterns of care. However, findings regarding geographical variations in tumour characteristics or diagnostic outcomes were inconsistent. Conclusions A general pattern of poorer survival and variations in clinical management for Australian female patients with breast cancer from non-metropolitan areas was evident. However, the wide variability in data sources, measures, study quality, time periods and geographical classification made direct comparisons across studies challenging. The review highlighted the need to promote standardisation of geographical classifications and increased comparability of data systems. It also identified key gaps in the existing literature including a lack of studies on advanced breast cancer, geographical variations in treatment choices from the perspective of patients and post-treatment follow-up. PMID:29706597

Genomic characteristics of cattle copy number variations

USDA-ARS?s Scientific Manuscript database

We performed a systematic analysis of cattle copy number variations (CNVs) using the Bovine HapMap SNP genotyping data, including 539 animals of 21 modern cattle breeds and 6 outgroups. After correcting genomic waves and considering the trio information, we identified 682 candidate CNV regions (CNVR...

Continuity and Variation in Chinese Patterns of Socialization.

ERIC Educational Resources Information Center

Ho, David Y. F.

1989-01-01

Reviews literature on Chinese patterns of socialization. Discusses methodological issues with respect to continuity versus change through time, and variation across geographical locations, systematically considering variables of gender, age, and social class. Concludes that departures from traditional pattern in different locations are evident,…

Statistical process control and verifying positional accuracy of a cobra motion couch using step-wedge quality assurance tool.

PubMed

Binny, Diana; Lancaster, Craig M; Trapp, Jamie V; Crowe, Scott B

2017-09-01

This study utilizes process control techniques to identify action limits for TomoTherapy couch positioning quality assurance tests. A test was introduced to monitor accuracy of the applied couch offset detection in the TomoTherapy Hi-Art treatment system using the TQA "Step-Wedge Helical" module and MVCT detector. Individual X-charts, process capability (cp), probability (P), and acceptability (cpk) indices were used to monitor a 4-year couch IEC offset data to detect systematic and random errors in the couch positional accuracy for different action levels. Process capability tests were also performed on the retrospective data to define tolerances based on user-specified levels. A second study was carried out whereby physical couch offsets were applied using the TQA module and the MVCT detector was used to detect the observed variations. Random and systematic variations were observed for the SPC-based upper and lower control limits, and investigations were carried out to maintain the ongoing stability of the process for a 4-year and a three-monthly period. Local trend analysis showed mean variations up to ±0.5 mm in the three-monthly analysis period for all IEC offset measurements. Variations were also observed in the detected versus applied offsets using the MVCT detector in the second study largely in the vertical direction, and actions were taken to remediate this error. Based on the results, it was recommended that imaging shifts in each coordinate direction be only applied after assessing the machine for applied versus detected test results using the step helical module. User-specified tolerance levels of at least ±2 mm were recommended for a test frequency of once every 3 months to improve couch positional accuracy. SPC enables detection of systematic variations prior to reaching machine tolerance levels. Couch encoding system recalibrations reduced variations to user-specified levels and a monitoring period of 3 months using SPC facilitated in detecting systematic and random variations. SPC analysis for couch positional accuracy enabled greater control in the identification of errors, thereby increasing confidence levels in daily treatment setups. © 2017 Royal Brisbane and Women's Hospital, Metro North Hospital and Health Service. Journal of Applied Clinical Medical Physics published by Wiley Periodicals, Inc. on behalf of American Association of Physicists in Medicine.

The systematics and population genetics of Opisthorchis viverrini sensu lato: implications in parasite epidemiology and bile duct cancer.

PubMed

Sithithaworn, Paiboon; Andrews, Ross H; Petney, Trevor N; Saijuntha, Weerachai; Laoprom, Nonglak

2012-03-01

Together with host and environmental factors, the systematics and population genetic variation of Opisthorchis viverrini may contribute to recorded local and regional differences in epidemiology and host morbidity in opisthorchiasis and cholangiocarcinoma (CCA). In this review, we address recent findings that O. viverrini comprises a species complex with varying degrees of population genetic variation which are associated with specific river wetland systems within Thailand as well as the Lao PDR. Having an accurate understanding of systematics is a prerequisite for a meaningful assessment of the population structure of each species within the O. viverrini complex in nature, as well as a better understanding of the magnitude of genetic variation that occurs within different species of hosts in its life cycle. Whether specific genotypes are related to habitat type(s) and/or specific intermediate host species are discussed based on current available data. Most importantly, we focus on whether there is a correlation between incidence of CCA and genotype(s) of O. viverrini. This will provide a solid basis for further comprehensive investigations of the role of genetic variation within each species of O. viverrini sensu lato in human epidemiology and genotype related morbidity as well as co-evolution of parasites with primary and secondary intermediate species of host. Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

Effects of variation in coagulation and photochemistry parameters on the particle size distributions in the Venus clouds

NASA Astrophysics Data System (ADS)

McGouldrick, Kevin

2017-12-01

This paper explores the effects that variation in the coalescence efficiency of the Venus cloud particles can have on the structure of the Venus cloud. It is motivated by the acknowledgment of uncertainties in the measured parameters—and the assumptions made to account for them—that define our present knowledge of the particle characteristics. Specifically, we explore the consequence of allowing the coalescence efficiency of supercooled sulfuric acid in the upper clouds to tend to zero. This produces a cloud that occasionally exhibits an enhancement of small particles at altitude (similar to the upper hazes observed by Pioneer Venus and subsequently shown to be somewhat transient). This simulated cloud occasionally exhibits a rapid growth of particle size near cloud base, exhibiting characteristics similar to those seen in the controversial Mode 3 particles. These results demonstrate that a subset of the variations observed as near-infrared opacity variations in the lower and middle clouds of Venus can be explained by microphysical, in addition to dynamical, variations. Furthermore, the existence of a population of particles exhibiting less efficient coalescence efficiencies would support the likelihood of conditions suitable for charge exchange, hence lightning, in the Venus clouds. We recommend future laboratory studies on the coalescence properties of sulfuric acid under the range of conditions experienced in the Venus clouds. We also recommend future in situ measurements to better characterize the properties of the cloud particles themselves, especially composition and particle habits (shapes).[Figure not available: see fulltext.

Genomic and evolutionary characteristics of cattle copy number variations

USDA-ARS?s Scientific Manuscript database

We performed a systematic analysis of cattle copy number variations (CNVs) using the Bovine HapMap SNP genotyping data, including 539 animals of 21 modern cattle breeds and 6 outgroups. After correcting genomic waves and considering the trio information, we identified 682 candidate CNV regions (CNVR...

Intermittent tremor migrations beneath Guerrero, Mexico, and implications for fault healing within the slow slip zone

NASA Astrophysics Data System (ADS)

Peng, Yajun; Rubin, Allan M.

2017-01-01

Slow slip events exhibit significant complexity in slip evolution and variations in recurrence intervals. Behavior that varies systematically with recurrence interval is likely to reflect different extents of fault healing between these events. Here we use high-resolution tremor catalogs beneath Guerrero, Mexico, to investigate the mechanics of slow slip. We observe complex tremor propagation styles, including rapid tremor migrations propagating either along the main tremor front or backward, reminiscent of those in northern Cascadia. We also find many migrations that originate well behind the front and repeatedly occupy the same source region during a tremor episode, similar to those previously reported from Shikoku, Japan. These migrations could be driven by slow slip in the surrounding regions, with recurrence intervals possibly modulated by tides. The propagation speed of these migrations decreases systematically with time since the previous migration over the same source area. Tremor amplitudes seem consistent with changes in the propagation speeds being controlled primarily by changes in the slip speeds. One interpretation is that the high propagation speeds and inferred high slip speeds during the migrations with short recurrence intervals are caused by incomplete healing within the host rock adjacent to the shear zone, which could lead to high permeability and reduced dilatant strengthening of the fault gouge. Similar processes may operate in other slow slip source regions such as Cascadia.

A general method for the layout of ailerons and elevators of gliders and motorplanes

NASA Technical Reports Server (NTRS)

Hiller, M. H.

1979-01-01

A method is described which allows the layout of the spatial driving mechanism of the aileron for a glider or a motorplane to be performed in a systematic manner. In particular, a prescribed input-output behavior of the mechanism can be realized by variation of individual parameters of the spatial four-bar mechanisms which constitute the entire driving mechanism. By means of a sensitivity analysis, a systematic choice of parameters is possible. At the same time the forces acting in the mechanism can be limited by imposing maximum values of the forces as secondary conditions during the variation process.

The permafrost carbon inventory on the Tibetan Plateau: a new evaluation using deep sediment cores

NASA Astrophysics Data System (ADS)

Yang, Y.; Ding, J.; Li, F.; Yang, G.; Chen, L.

2016-12-01

The permafrost organic carbon (OC) stock is of global significance because of its large pool size and potential positive feedback to climate warming. However, due to the lack of systematic field observations and appropriate upscaling methodologies, substantial uncertainties exist in the permafrost OC budget, which limits our understanding on the fate of frozen carbon in a warming world. In particular, the lack of comprehensive estimation of OC stock across alpine permafrost means that the current knowledge on this issue remains incomplete. Here we evaluated the pool size and spatial variations of permafrost OC stock to 3 meters depth on the Tibetan Plateau by combining systematic measurements from a substantial number of pedons (i.e., 342 three-meter-deep cores and 177 50-cm-deep pits) with a machine learning technique (i.e., support vector machine, SVM). We also quantified uncertainties in permafrost carbon budget by conducting Monte Carlo simulation. Our results revealed that the combination of systematic measurements with the SVM model allowed spatially explicit estimates. The OC density (OC amount per unit area, OCD) exhibited a decreasing trend from the southeastern to the northwestern plateau, with the exception that OCD in the swamp meadow was substantially higher than that in surrounding regions. Our results also demonstrated that Tibetan permafrost stored a large amount of OC in the top 3 meters, with the median OC pool size being 15.31 Pg C (interquartile range: 13.03-17.77 Pg C). Of them, 44% occurred in deep layers (i.e., 100-300 cm), close to the proportion observed across the northern circumpolar permafrost region. The large carbon pool size, together with significant permafrost thawing implies a risk of carbon emissions and positive climate feedback across the Tibetan alpine permafrost region.

An international marine-atmospheric {sup 222}Rn measurement intercomparison in Bermuda. Part 2: Results for the participating laboratories

DOE Office of Scientific and Technical Information (OSTI.GOV)

Colle, R.; Unterweger, M.P.; Hutchinson, J.M.R.

1996-01-01

As part of an international measurement intercomparison of instruments used to measure atmospheric {sup 222}Rn, four participating laboratories made nearly simultaneous measurements of {sup 222}Rn activity concentration in commonly sampled, ambient air over approximately a 2 week period, and three of these four laboratories participated in the measurement comparison of 14 introduced samples with known, but undisclosed (blind) {sup 222}Rn activity concentration. The exercise was conducted in Bermuda in October 1991. The {sup 222}Rn activity concentrations in ambient Bermudian air over the course of the intercomparison ranged from a few hundredths of a Bq {center_dot} m{sup {minus}3} to about 2more » Bq {center_dot} m{sup {minus}3}, while the standardized sample additions covered a range from approximately 2.5 Bq {center_dot} m{sup {minus}3} to 35 Bq {center_dot} m{sup {minus}3}. The overall uncertainty in the latter concentrations was in the general range of 10%, approximating a 3 standard deviation uncertainty interval. The results of the intercomparison indicated that two of the laboratories were within very good agreement with the standard additions, and almost within expected statistical variations. These same two laboratories, however, at lower ambient concentrations, exhibited a systematic difference with an averaged offset of roughly 0.3 Bq {center_dot} m{sup {minus}3}. The third laboratory participating in the measurement of standardized sample additions was systematically low by about 65% to 70%, with respect to the standard addition which was also confirmed in their ambient air concentration measurements. The fourth laboratory, participating in only the ambient measurement part of the intercomparison, was also systematically low by at least 40% with respect to the first two laboratories.« less

The effect of copper, chromium, and zirconium on the microstructure and mechanical properties of Al-Zn-Mg-Cu alloys

NASA Technical Reports Server (NTRS)

Wagner, John A.; Shenoy, R. N.

1991-01-01

The present study evaluates the effect of the systematic variation of copper, chromium, and zirconium contents on the microstructure and mechanical properties of a 7000-type aluminum alloy. Fracture toughness and tensile properties are evaluated for each alloy in both the peak aging, T8, and the overaging, T73, conditions. Results show that dimpled rupture essentially characterize the fracture process in these alloys. In the T8 condition, a significant loss of toughness is observed for alloys containing 2.5 pct Cu due to the increase in the quantity of Al-Cu-Mg-rich S-phase particles. An examination of T8 alloys at constant Cu levels shows that Zr-bearing alloys exhibit higher strength and toughness than the Cr-bearing alloys. In the T73 condition, Cr-bearing alloys are inherently tougher than Zr-bearing alloys. A void nucleation and growth mechanism accounts for the loss of toughness in these alloys with increasing copper content.

Process and technoeconomic analysis of leading pretreatment technologies for lignocellulosic ethanol production using switchgrass.

PubMed

Tao, Ling; Aden, Andy; Elander, Richard T; Pallapolu, Venkata Ramesh; Lee, Y Y; Garlock, Rebecca J; Balan, Venkatesh; Dale, Bruce E; Kim, Youngmi; Mosier, Nathan S; Ladisch, Michael R; Falls, Matthew; Holtzapple, Mark T; Sierra, Rocio; Shi, Jian; Ebrik, Mirvat A; Redmond, Tim; Yang, Bin; Wyman, Charles E; Hames, Bonnie; Thomas, Steve; Warner, Ryan E

2011-12-01

Six biomass pretreatment processes to convert switchgrass to fermentable sugars and ultimately to cellulosic ethanol are compared on a consistent basis in this technoeconomic analysis. The six pretreatment processes are ammonia fiber expansion (AFEX), dilute acid (DA), lime, liquid hot water (LHW), soaking in aqueous ammonia (SAA), and sulfur dioxide-impregnated steam explosion (SO(2)). Each pretreatment process is modeled in the framework of an existing biochemical design model so that systematic variations of process-related changes are consistently captured. The pretreatment area process design and simulation are based on the research data generated within the Biomass Refining Consortium for Applied Fundamentals and Innovation (CAFI) 3 project. Overall ethanol production, total capital investment, and minimum ethanol selling price (MESP) are reported along with selected sensitivity analysis. The results show limited differentiation between the projected economic performances of the pretreatment options, except for processes that exhibit significantly lower monomer sugar and resulting ethanol yields. Copyright © 2011 Elsevier Ltd. All rights reserved.

USING LEAKED POWER TO MEASURE INTRINSIC AGN POWER SPECTRA OF RED-NOISE TIME SERIES

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhu, S. F.; Xue, Y. Q., E-mail: zshifu@mail.ustc.edu.cn, E-mail: xuey@ustc.edu.cn

Fluxes emitted at different wavebands from active galactic nuclei (AGNs) fluctuate at both long and short timescales. The variation can typically be characterized by a broadband power spectrum, which exhibits a red-noise process at high frequencies. The standard method of estimating the power spectral density (PSD) of AGN variability is easily affected by systematic biases such as red-noise leakage and aliasing, in particular when the observation spans a relatively short period and is gapped. Focusing on the high-frequency PSD that is strongly distorted due to red-noise leakage and usually not significantly affected by aliasing, we develop a novel and observablemore » normalized leakage spectrum (NLS), which sensitively describes the effects of leaked red-noise power on the PSD at different temporal frequencies. Using Monte Carlo simulations, we demonstrate how an AGN underlying PSD sensitively determines the NLS when there is severe red-noise leakage, and thereby how the NLS can be used to effectively constrain the underlying PSD.« less

A study on dependence of the structural, optical and electrical properties of cadmium lead sulphide thin films on Cd/Pb ratio

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nair, Sinitha B., E-mail: sinithanair@gmail.com, E-mail: anithakklm@gmail.com; Abraham, Anitha, E-mail: sinithanair@gmail.com, E-mail: anithakklm@gmail.com; Philip, Rachel Reena, E-mail: reenatara@rediffmail.com

2014-10-15

Cadmium Lead Sulphide thin films with systematic variation in Cd/Pb ratio are prepared at 333K by CBD, adjusting the reagent-molarity, deposition time and pH. XRD exhibits crystalline-amorphous transition as Cd% exceeds Pb%. AFM shows agglomeration of crystallites of size ∼50±5 nm. EDAX assess the composition whereas XPS ascertains the ternary formation, with binding energies of Pb4f{sub 7/2} and 4f{sub 5/2}, Cd3d{sub 5/2} and 3d{sub 3/2} and S2p at 137.03, 141.606, 404.667, 412.133 and 160.218 eV respectively. The optical absorption spectra reveal the variance in the direct allowed band gaps, from 1.57eV to 2.42 eV as Cd/Pb ratio increases from 0.2more » to 2.7, suggesting possibility of band gap engineering in the n-type films.« less

Modulation of Folding Internal Friction by Local and Global Barrier Heights.

PubMed

Zheng, Wenwei; de Sancho, David; Best, Robert B

2016-03-17

Recent experiments have revealed an unexpected deviation from a first power dependence of protein relaxation times on solvent viscosity, an effect that has been attributed to "internal friction". One clear source of internal friction in protein dynamics is the isomerization of dihedral angles. A key outstanding question is whether the global folding barrier height influences the measured internal friction, based on the observation that the folding rates of fast-folding proteins, with smaller folding free energy barriers, tend to exhibit larger internal friction. Here, by studying two alanine-based peptides, we find that systematic variation of global folding barrier heights has little effect on the internal friction for folding rates. On the other hand, increasing local torsion angle barriers leads to increased internal friction, which is consistent with solvent memory effects being the origin of the viscosity dependence. Thus, it appears that local torsion transitions determine the viscosity dependence of the diffusion coefficient on the global coordinate and, in turn, internal friction effects on the folding rate.

Slow-Injection Growth of Seeded CdSe/CdS Nanorods with Unity Fluorescence Quantum Yield and Complete Shell to Core Energy Transfer.

PubMed

Coropceanu, Igor; Rossinelli, Aurelio; Caram, Justin R; Freyria, Francesca S; Bawendi, Moungi G

2016-03-22

A two-step process has been developed for growing the shell of CdSe/CdS core/shell nanorods. The method combines an established fast-injection-based step to create the initial elongated shell with a second slow-injection growth that allows for a systematic variation of the shell thickness while maintaining a high degree of monodispersity at the batch level and enhancing the uniformity at the single-nanorod level. The second growth step resulted in nanorods exhibiting a fluorescence quantum yield up to 100% as well as effectively complete energy transfer from the shell to the core. This improvement suggests that the second step is associated with a strong suppression of the nonradiative channels operating both before and after the thermalization of the exciton. This hypothesis is supported by the suppression of a defect band, ubiquitous to CdSe-based nanocrystals after the second growth.

Small Molecule Activation by Intermolecular Zr(IV)-Phosphine Frustrated Lewis Pairs.

PubMed

Metters, Owen J; Forrest, Sebastian J K; Sparkes, Hazel A; Manners, Ian; Wass, Duncan F

2016-02-17

We report intermolecular transition metal frustrated Lewis pairs (FLPs) based on zirconocene aryloxide and phosphine moieties that exhibit a broad range of small molecule activation chemistry that has previously been the preserve of only intramolecular pairs. Reactions with D2, CO2, THF, and PhCCH are reported. By contrast with previous intramolecular examples, these systems allow facile access to a variety of steric and electronic characteristics at the Lewis acidic and Lewis basic components, with the three-step syntheses of 10 new intermolecular transition metal FLPs being reported. Systematic variation to the phosphine Lewis base is used to unravel steric considerations, with the surprising conclusion that phosphines with relatively small Tolman steric parameters not only give highly reactive FLPs but are often seen to have the highest selectivity for the desired product. DOSY NMR spectroscopic studies on these systems reveal for the first time the nature of the Lewis acid/Lewis base interactions in transition metal FLPs of this type.

Cantharellus violaceovinosus, a new species from tropical Quercus forests in eastern Mexico

PubMed Central

Herrera, Mariana; Bandala, Victor M.; Montoya, Leticia

2018-01-01

Abstract During explorations of tropical oak forests in central Veracruz (eastern Mexico), the authors discovered a Cantharellus species that produces basidiomes with strikingly violet pileus and a hymenium with yellow, raised gill-like folds. It is harvested locally and valued as a prized edible wild mushroom. Systematic multiyear sampling of basidiomes allowed the recording of the morphological variation exhibited by fresh fruit bodies in different growth stages, which supports the recognition of this Cantharellus species from others in the genus. Two molecular phylogenetic analyses based on a set of sequences of species of all major clades in Cantharellus, one including sequences of the transcription elongation factor 1-alpha (tef-1α) and a combined tef-1α and nLSU region (the large subunit of the ribosome), confirm the isolated position of the new species in a clade close to C. lewisii from USA, in the subgenus Cantharellus. Detailed macroscopic and microscopic descriptions, accompanied by illustrations and a taxonomic discussion are presented. PMID:29681739

Cantharellus violaceovinosus, a new species from tropical Quercus forests in eastern Mexico.

PubMed

Herrera, Mariana; Bandala, Victor M; Montoya, Leticia

2018-01-01

During explorations of tropical oak forests in central Veracruz (eastern Mexico), the authors discovered a Cantharellus species that produces basidiomes with strikingly violet pileus and a hymenium with yellow, raised gill-like folds. It is harvested locally and valued as a prized edible wild mushroom. Systematic multiyear sampling of basidiomes allowed the recording of the morphological variation exhibited by fresh fruit bodies in different growth stages, which supports the recognition of this Cantharellus species from others in the genus. Two molecular phylogenetic analyses based on a set of sequences of species of all major clades in Cantharellus , one including sequences of the transcription elongation factor 1-alpha (tef-1α) and a combined tef-1α and nLSU region (the large subunit of the ribosome), confirm the isolated position of the new species in a clade close to C. lewisii from USA, in the subgenus Cantharellus. Detailed macroscopic and microscopic descriptions, accompanied by illustrations and a taxonomic discussion are presented.

Political complexity predicts the spread of ethnolinguistic groups

PubMed Central

Currie, Thomas E.; Mace, Ruth

2009-01-01

Human languages show a remarkable degree of variation in the area they cover. However, the factors governing the distribution of human cultural groups such as languages are not well understood. While previous studies have examined the role of a number of environmental variables the importance of cultural factors has not been systematically addressed. Here we use a geographical information system (GIS) to integrate information about languages with environmental, ecological, and ethnographic data to test a number of hypotheses that have been proposed to explain the global distribution of languages. We show that the degree of political complexity and type of subsistence strategy exhibited by societies are important predictors of the area covered by a language. Political complexity is also strongly associated with the latitudinal gradient in language area, whereas subsistence strategy is not. We argue that a process of cultural group selection favoring more complex societies may have been important in shaping the present-day global distribution of language diversity. PMID:19380740

Upper Mantle Texture Patterns In Eastern North America From Seismic Anisotropy And Global Mantle Flow Calculations

NASA Astrophysics Data System (ADS)

Levin, V. L.; Moucha, R.; Yuan, H.

2013-12-01

Global seismic models show gradual and systematic changes in upper mantle seismic properties beneath North America. Faster and thicker lithosphere of the interior thins eastward. Upper mantle rock fabric reflected in observations of seismic anisotropy also varies. Near the coast apparent fast directions of split shear waves are nearly east-west, with considerable scatter. Further inland they are more uniform and align SW-NE, close to the absolute plate motion direction of North America. Mantle convection simulations driven by density inferred from global joint seismic-geodynamic tomography models exhibit complex flow beneath the eastern edge of the North American continent due to the ongoing descent of the Farallon slab deep beneath it (figure 1). Flow predicted beneath the coast is nearly horizontal with a small, though dynamically important, vertical component, while west of the Appalachians it turns downward. Long records of teleseismic observations accumulated at permanent seismic stations HRV, PAL and SSPA (figure 2) are inverted for vertical distribution of anisotropic parameters. We find preference for more than one layer of anisotropy beneath all sites, with significantly different parameters that could reflect either lateral variations in the lithospheric thickness, variations in the asthenospheric flow field, or both. Since we find considerable consistency in directional patterns of P-to-S mode converted waves associated with the lower part of the lithosphere, variations of asthenospheric flow seem to be a more plausible explanation. We explore the links between predicted flow and inferences from seismic data with additional observations of anisotropy and calculations of flow-induced rock fabric.

Breakup of a liquid rivulet falling over an inclined plate: Identification of a critical Weber number

DOE Office of Scientific and Technical Information (OSTI.GOV)

Singh, Rajesh K.; Galvin, Janine E.; Whyatt, Greg A.

2017-05-01

We have numerically investigated the breakup of a rivulet falling over a smooth inclined plate using the volume of fluid method. The breakup the rivulet is a complex phenomenon that is dictated by many factors, such as solvent properties, contact angle, inertia, plate inclination, etc. An extensive simulation campaign was conducted wherein these factors were systematically investigated. Regimes for a stable rivulet and an unstable rivulet that leads to the breakup and formation of a droplet are examined in terms of a critical value of the Weber number (Wecr) that delineates these regimes. The effect of plate inclination on themore » breakup of the rivulet shows that the critical Weber number decreases with increased inclination angle () owing to higher liquid velocity. However, the effect is negligible beyond >60. The impact of solvent properties is characterized using the Kapitza number (Ka). Variation of Wecr with Ka shows two trends depending on the Ka value of the solvent. Solvents with lower Ka values, corresponding to high viscosities and/or low surface tensions, show smaller values of the critical Weber number and the variation is linear. While solvents with higher Ka values exhibit higher values of the Wecr and the variation in Wecr is steep. This behavior is more pronounced with increasing contact angle. Higher contact angles promote rivulet breakup so that inertia must be higher to the breakup. A phenomenological scaling for a critical Weber number with the Kapitza number and contact angle is presented that can offer insight into rivulet breakup.« less

Acquiring Constraints on Morphosyntactic Variation: Children's Spanish Subject Pronoun Expression

ERIC Educational Resources Information Center

Shin, Naomi Lapidus

2016-01-01

Constraints on linguistic variation are consistent across adult speakers, yielding probabilistic and systematic patterns. Yet, little is known about the development of such patterns during childhood. This study investigates Spanish subject pronoun expression in naturalistic data from 154 monolingual children in Mexico, divided into four age…

Investigating Black ASL: A Systematic Review

ERIC Educational Resources Information Center

Toliver-Smith, Andrea; Gentry, Betholyn

2017-01-01

The authors reviewed the literature regarding linguistic variations seen in American Sign Language. These variations are influenced by region and culture. Features of spoken languages have also influenced sign languages as they intersected, e.g., Black ASL has been influenced by African American English. A literature review was conducted to…

DOE Office of Scientific and Technical Information (OSTI.GOV)

Skordas, E. S., E-mail: eskordas@phys.uoa.gr

By applying Detrended Fluctuation Analysis (DFA) to the time series of the geomagnetic data recorded at three measuring stations in Japan, Rong et al. in 2012 recently reported that anomalous magnetic field variations were identified well before the occurrence of the disastrous Tohoku M{sub w}9.0 earthquake that occurred on 11 March 2011 in Japan exhibiting increased “non-uniform” scaling behavior. Here, we provide an explanation for the appearance of this increase of “non-uniform” scaling on the following grounds: These magnetic field variations are the ones that accompany the electric field variations termed Seismic Electric Signals (SES) activity which have been repeatedlymore » reported that precede major earthquakes. DFA as well as multifractal DFA reveal that the latter electric field variations exhibit scaling behavior as shown by analyzing SES activities observed before major earthquakes in Greece. Hence, when these variations are superimposed on a background of pseudosinusoidal trend, their long range correlation properties—quantified by DFA—are affected resulting in an increase of the “non-uniform” scaling behavior. The same is expected to hold for the former magnetic field variations. This explanation is strengthened by recent findings showing that the fluctuations of the order parameter of seismicity exhibited an unprecedented minimum almost two months before the Tohoku earthquake occurrence which is characteristic for an almost simultaneous emission of Seismic Electric Signals activity.« less

Community and Art: Creative Education Fostering Resilience through Art

ERIC Educational Resources Information Center

Kim, Hyungsook

2015-01-01

While creativity is discussed as a core competence for talented people around the world in the twenty-first century, its exhibition is determined by one's character. Creativity and character education, therefore, should not be considered as separate matters, but the systematically related matters, and exhibition of creativity, can be carried away…

Biomarker patterns in present-day vegetation: consistency and variation - A study on plaggen soils

NASA Astrophysics Data System (ADS)

Kirkels, Frédérique; Jansen, Boris; Kalbitz, Karsten

2013-04-01

Biomarker patterns in present-day vegetation are commonly used as proxies to reconstruct paleo-vegetation composition, land use history and to elucidate carbon cycling. Plaggen soils are formed by diverse vegetational inputs during century-long plaggen (i.e. sod) application associated with plaggen-agriculture on poor soils in north-western Europe. This resulted in remarkably stable organic matter. Plant source identification by biomarkers could provide insight in yet unknown stabilization mechanisms and the fate of organic matter upon ongoing land use change. The current rationale behind biomarker-based source identification is that patterns observed in present-day vegetation are generally representative with little random variation. However, our knowledge on variability and consistency of biomarker patterns is yet scarce. Therefore, to assess the applicability of biomarkers for source identification in plaggen soils, we analyzed published n-alkane and n-alcohol patterns of species and their various parts which contribute(d) input to plaggen soils. We considered shrubs, trees and grass species and evaluated rescaled patterns (i.e. relative abundances in chain-length range C17-36), odd-over-even predominance (OEP) and predominant n-alkanes. In addition, we explicitly looked into potential sources of systematic variation, e.g. spatial variation (climate, site conditions), temporal variation (seasonality, ontogeny) and laboratory methodology (extraction technique: washing/shaking, Soxhlet/ASE, saponification). We found meaningful clustering of n-alkanes C27, C29, C31 and C33, allowing for clear distinction of input by shrubs, trees and grasses to plaggen soils. Combination of these homologues with complete n-alkane patterns (C17-36) and OEP enabled further differentiation, while n-alcohols patterns were less distinct. Current limitation is the lack of extended and diverse quantitative records on biomarker patterns, especially for n-alcohols, non-leaf and belowground tissues, which hindered full statistical analysis. On species level we also recognized outliers and spreading. Systematic variation was indicated among tree species according to spatial conditions and by ontogeny. Yet, observed effects were ambiguous for other variation sources. This study highlights clear opportunities for application of biomarker patterns for source identification and elucidation of stabilization processes in (plaggen) soils. At the same time, application is challenged by systematic variation. Further research is key to quantify controls, magnitude and potential correction factors for such systematic variation. This would validate the use of n-alkane and n-alcohol patterns across broad spatial and temporal scales or identify boundaries wherein their consistency is ensured. Likely, these challenges apply to vegetation in a broad perspective, transcending plaggen vegetation, as assessment and application of present-day vegetation patterns is emerging.

Phenotypic variation in California populations of valley oak (Quercus lobata Née) sampled along elevational gradients

Treesearch

Ana L. Albarrán-Lara; Jessica W. Wright; Paul F. Gugger; Annette Delfino-Mix; Juan Manuel Peñaloza-Ramírez; Victoria L. Sork

2015-01-01

California oaks exhibit tremendous phenotypic variation throughout their range. This variation reflects phenotypic plasticity in tree response to local environmental conditions as well as genetic differences underlying those phenotypes. In this study, we analyze phenotypic variation in leaf traits for valley oak adults sampled along three elevational transects and in...

Selection and sex-biased dispersal in a coastal shark: the influence of philopatry on adaptive variation.

PubMed

Portnoy, D S; Puritz, J B; Hollenbeck, C M; Gelsleichter, J; Chapman, D; Gold, J R

2015-12-01

Sex-biased dispersal is expected to homogenize nuclear genetic variation relative to variation in genetic material inherited through the philopatric sex. When site fidelity occurs across a heterogeneous environment, local selective regimes may alter this pattern. We assessed spatial patterns of variation in nuclear-encoded, single nucleotide polymorphisms (SNPs) and sequences of the mitochondrial control region in bonnethead sharks (Sphyrna tiburo), a species thought to exhibit female philopatry, collected from summer habitats used for gestation. Geographic patterns of mtDNA haplotypes and putatively neutral SNPs confirmed female philopatry and male-mediated gene flow along the northeastern coast of the Gulf of Mexico. A total of 30 outlier SNP loci were identified; alleles at over half of these loci exhibited signatures of latitude-associated selection. Our results indicate that in species with sex-biased dispersal, philopatry can facilitate sorting of locally adaptive variation, with the dispersing sex facilitating movement of potentially adaptive variation among locations and environments. © 2015 John Wiley & Sons Ltd.

Variations of Scale Height at F-Region Peak Based on Ionosonde Measurements during Solar Maximum over the Crest of Equatorial Ionization Anomaly Region

PubMed Central

Chuo, Yu-Jung

2014-01-01

Scale height is an important parameter in characterizing the shape of the ionosphere and its physical processes. In this study, we attempt to examine and discuss the variation of scale height, H m, around the F-layer peak height during high solar activity at the northern crest of the equatorial ionization anomaly (EIA) region. H m exhibits day-to-day variation and seasonal variation, with a greater average daily variation during daytime in summer. Furthermore, the diurnal variation of H m exhibits an abnormal peak at presunrise during all the seasons, particularly in winter. This increase is also observed in the F2-layer peak height for the same duration with an upward movement associated with thermospheric wind toward the equator; this upward movement increases the N2/O ratio and H m, but it causes a decrease in the F2-layer maximum critical frequency during the presunrise period. PMID:25162048

Measurement of plasminogen activator inhibitor type 1 antigen: comparison of Tintelize and Imubind methods.

PubMed

Stroop, D M; Glueck, C J; Tracy, T M; Schumacher, H R

1994-12-01

Our specific aim was to compare three plasminogen activator-inhibitor type 1 (PAI-1) antigen ELISA kit assays (the Biopool AB, Ltd, TintElize PAI-1 Strip-Well Format; the American Diagnostica, Inc., Imubind 822/1; and the second generation Imubind 822/1S). Within-run coefficients of variation (n = 6) for the TintElize, Imubind 822/1 and Imubind 822/1S methods were 5.5%, 5.9% and 6.8%, respectively. Between-run coefficients of variation for six aliquots per run were 2.9% for TintElize, 3.8% for Imubind 822/1, and 3.5% for Imubind 822/1S. Comparison of the average of duplicate aliquots from hyperlipidaemic patients demonstrated intraclass correlations of 0.75, 0.79 and 0.95 for TintElize vs Imubind 822/1 (n = 39), TintElize vs Imubind 822/1S (n = 39), and Imubind 822/1 vs 822/1S (n = 84), respectively. Lower 95% confidence interval limits of the intraclass correlation were 0.55, 0.48 and 0.93, respectively. Mean PAI-1 antigen values (n = 39) were 12.1, 15.8, 15.8 and 16.0 ng/ml, respectively, for TintElize, TintElize without using the quenching well, Imubind 822/1, and Imubind 822/1S. All three methods were easily performed and exhibited high correlation and reproducibility. A significant systematic bias (P < 0.006) existed between TintElize and TintElize without using the quenching well, Imubind 822/1, and Imubind 822/1S. However, there was no significant bias when TintElize without using the quenching well is compared with Imubind 822/1 (P > 0.8) and to 822/1S (P > 0.8) nor is there significant systematic bias between Imubind 822/1 and 822/1S (P > 0.3). By convention, interchangeability between assay methods suggests that the lower limit of the 95% intraclass correlation confidence interval be greater than 0.75.(ABSTRACT TRUNCATED AT 250 WORDS)

GALA: group analysis leads to accuracy, a novel approach for solving the inverse problem in exploratory analysis of group MEG recordings

PubMed Central

Kozunov, Vladimir V.; Ossadtchi, Alexei

2015-01-01

Although MEG/EEG signals are highly variable between subjects, they allow characterizing systematic changes of cortical activity in both space and time. Traditionally a two-step procedure is used. The first step is a transition from sensor to source space by the means of solving an ill-posed inverse problem for each subject individually. The second is mapping of cortical regions consistently active across subjects. In practice the first step often leads to a set of active cortical regions whose location and timecourses display a great amount of interindividual variability hindering the subsequent group analysis. We propose Group Analysis Leads to Accuracy (GALA)—a solution that combines the two steps into one. GALA takes advantage of individual variations of cortical geometry and sensor locations. It exploits the ensuing variability in electromagnetic forward model as a source of additional information. We assume that for different subjects functionally identical cortical regions are located in close proximity and partially overlap and their timecourses are correlated. This relaxed similarity constraint on the inverse solution can be expressed within a probabilistic framework, allowing for an iterative algorithm solving the inverse problem jointly for all subjects. A systematic simulation study showed that GALA, as compared with the standard min-norm approach, improves accuracy of true activity recovery, when accuracy is assessed both in terms of spatial proximity of the estimated and true activations and correct specification of spatial extent of the activated regions. This improvement obtained without using any noise normalization techniques for both solutions, preserved for a wide range of between-subject variations in both spatial and temporal features of regional activation. The corresponding activation timecourses exhibit significantly higher similarity across subjects. Similar results were obtained for a real MEG dataset of face-specific evoked responses. PMID:25954141

Variable electron correlation in high-quality MBE- and PLD-grown SrRuO3 thin films.

NASA Astrophysics Data System (ADS)

Siemons, Wolter; Koster, Gertjan; Yamamoto, Hideki; Vailionis, Arturas; Geballe, Theodore; Blank, Dave; Beasley, Malcolm

2007-03-01

We show that systematic variations in the degree of correlation can occur within SrRuO3 as a function of disorder/off-stoichiometry. In particular, we find that one source of disorder can be controlled in SrRuO3 thin films by varying the deposition conditions or the deposition technique. Specifically, we clearly demonstrate that variation of vacancies on the ruthenium site gives rise to a variation in correlated behavior as seen in the photoemission spectra (XPS and UPS),. Moreover, the transport properties of our samples are clearly linked to their photoemission spectra, and independently the crystal unit cell parameters. SrRuO3 appears to be a system where these effects can be studied in a more systematic fashion, usually not easily accessible, but we suspect that the underlying physics is generic in complex oxidesWork supported by the DoE BES and EPRI.

Consensus and stratification in the affective meaning of human sociality

PubMed Central

Ambrasat, Jens; von Scheve, Christian; Conrad, Markus; Schauenburg, Gesche; Schröder, Tobias

2014-01-01

We investigate intrasocietal consensus and variation in affective meanings of concepts related to authority and community, two elementary forms of human sociality. Survey participants (n = 2,849) from different socioeconomic status (SES) groups in German society provided ratings of 909 social concepts along three basic dimensions of affective meaning. Results show widespread consensus on these meanings within society and demonstrate that a meaningful structure of socially shared knowledge emerges from organizing concepts according to their affective similarity. The consensus finding is further qualified by evidence for subtle systematic variation along SES differences. In relation to affectively neutral words, high-status individuals evaluate intimacy-related and socially desirable concepts as less positive and powerful than middle- or low-status individuals, while perceiving antisocial concepts as relatively more threatening. This systematic variation across SES groups suggests that the affective meaning of sociality is to some degree a function of social stratification. PMID:24843121

[Trend in potentially avoidable hospitalisations for chronic conditions in Spain].

PubMed

Angulo-Pueyo, Ester; Martínez-Lizaga, Natalia; Ridao-López, Manuel; García-Armesto, Sandra; Bernal-Delgado, Enrique

2016-01-01

To analyse the trend in potentially avoidable hospitalisations (PAH) in frail patients or those with chronic conditions in Spain during the period 2002-2013. An observational, ecological study was conducted to analyse the trend in age-sex standardised rates of PAH affecting six clinical conditions, and their variation, in the 203 health care areas composing the publicly-funded health system in Spain. During the period 2002-2013, overall PAH standardised rates decreased by 35%, but systematic variation remained moderately high, around 13% above that expected by chance. Angina admissions showed the largest reduction, followed by those for asthma and chronic obstructive pulmonary disease. In contrast, the prevalence of admissions for dehydration doubled. Despite the decrease in PAH rates, systematic variation among areas remains, indicating differences in chronic care management that lead to distinct healthcare outcomes. Copyright © 2015 SESPAS. Published by Elsevier Espana. All rights reserved.

Inter-doctor variations in the assessment of functional incapacities by insurance physicians

PubMed Central

2011-01-01

Background The aim of this study was to determine the - largely unexplored - extent of systematic variation in the work disability assessment by Dutch insurance physicians (IPs) of employees on long-term sick leave, and to ascertain whether this variation was associated with the individual characteristics and opinions of IPs. Methods In March 2008 we conducted a survey among IPs on the basis of the 'Attitude - Social norm - self-Efficacy' (ASE) model. We used the ensuing data to form latent variables for the ASE constructs. We then linked the background variables and the measured constructs for IPs (n = 199) working at regional offices (n = 27) to the work disability assessments of clients (n = 83,755) and their characteristics. These assessments were carried out between July 2003 and April 2008. We performed multilevel regression analysis on three important assessment outcomes: No Sustainable Capacity or Restrictions for Working Hours (binominal), Functional Incapacity Score (scale 0-6) and Maximum Work Disability Class (binominal). We calculated Intra Class Correlations (ICCs) at IP level and office level and explained variances (R2) for the three outcomes. A higher ICC reflects stronger systematic variation. Results The ICCs at IP level were approximately 6% for No Sustainable Capacity or Restrictions for Working Hours and Maximum Work Disability Class and 12% for Functional Incapacity Score. Background IP variables and the measured ASE constructs for physicians contributed very little to the variation - at most 1%. The ICCs at office level ranged from 0% to around 1%. The R2 was 11% for No Sustainable Capacity or Restrictions for Working Hours, 19% for Functional Incapacity Score and 37% for Maximum Work Disability Class. Conclusion Our study uncovered small to moderate systematic variations in the outcome of disability assessments in the Netherlands. However, the individual characteristics and opinions of insurance physicians have very little impact on these variations. Our findings provided no indications of other reasons for these variations. They may be related to different work routines or to different views on the workload of a 'normal' employee. If so, they could be reduced by well-developed and comprehensively implemented guidelines. Therefore, further research is needed. PMID:22077926

Intra-Specific Latitudinal Clines in Leaf Carbon, Nitrogen, and Phosphorus and their Underlying Abiotic Correlates in Ruellia Nudiflora.

PubMed

Abdala-Roberts, Luis; Covelo, Felisa; Parra-Tabla, Víctor; Terán, Jorge C Berny Mier Y; Mooney, Kailen A; Moreira, Xoaquín

2018-01-12

While plant intra-specific variation in the stoichiometry of nutrients and carbon is well documented, clines for such traits have been less studied, despite their potential to reveal the mechanisms underlying such variation. Here we analyze latitudinal variation in the concentration of leaf nitrogen (N), phosphorus (P), carbon (C) and their ratios across 30 populations of the perennial herb Ruellia nudiflora. In addition, we further determined whether climatic and soil variables underlie any such latitudinal clines in leaf traits. The sampled transect spanned 5° latitude (ca. 900 km) and exhibited a four-fold precipitation gradient and 2 °C variation in mean annual temperature. We found that leaf P concentration increased with precipitation towards lower latitudes, whereas N and C did not exhibit latitudinal clines. In addition, N:P and C:P decreased towards lower latitudes and latitudinal variation in the former was weakly associated with soil conditions (clay content and cation exchange capacity); C:N did not exhibit a latitudinal gradient. Overall, these results emphasize the importance of addressing and disentangling the simultaneous effects of abiotic factors associated with intra-specific clines in plant stoichiometric traits, and highlight the previously underappreciated influence of abiotic factors on plant nutrients operating under sharp abiotic gradients over smaller spatial scales.

Diurnal Variation in Gravity Wave Activity at Low and Middle Latitudes

NASA Technical Reports Server (NTRS)

Andrioli, V. F.; Fritts, D. C.; Batista, P. P.; Clemesha, B. R.; Janches, Diego

2013-01-01

We employ a modified composite day extension of the Hocking (2005) analysis method to study gravity wave (GW) activity in the mesosphere and lower thermosphere using 4 meteor radars spanning latitudes from 7deg S to 53.6deg S. Diurnal and semidiurnal modulations were observed in GW variances over all sites. Semidiurnal modulation with downward phase propagation was observed at lower latitudes mainly near the equinoxes. Diurnal modulations occur mainly near solstice and, except for the zonal component at Cariri (7deg S), do not exhibit downward phase propagation. At a higher latitude (SAAMER, 53.6deg S) these modulations are only observed in the meridional component where we can observe diurnal variation from March to May, and semidiurnal, during January, February, October (above 88 km) and November. Some of these modulations with downward phase progression correlate well with wind shear. When the wind shear is well correlated with the maximum of the variances the diurnal tide has its largest amplitudes, i.e., near equinox. Correlations exhibiting variations with tidal phases suggest significant GW-tidal interactions that have different characters depending on the tidal components and possible mean wind shears. Modulations that do not exhibit phase variations could be indicative of diurnal variations in GW sources.

Phylogeny of Fomitopsis pinicola: A species complex

Treesearch

John Haight; Gary A. Laursen; Jessie A. Glaeser; D. Lee Taylor

2016-01-01

Fungal species with a broad distribution may exhibit considerable genetic variation over their geographic ranges. Variation may develop among populations based on geographic isolation, lack of migration, and genetic drift, though this genetic variation may not always be evident when examining phenotypic characters. Fomitopsis pinicola is an...

A physical model study of converted wave amplitude variation in a reservoir of systematically aligned vertical fractures

NASA Astrophysics Data System (ADS)

Chang, C.; Sun, L.; Lin, C.; Chang, Y.; Tseng, P.

2013-12-01

The existence of fractures not only provides spaces for the residence of oils and gases reside, but it also creates pathways for migration. Characterizing a fractured reservoir thus becomes an important subject and has been widely studied by exploration geophysicists and drilling engineers. In seismic anisotropy, a reservoir of systematically aligned vertical fractures (SAVF) is often treated as a transversely isotropic medium (TIM) with a horizontal axis of symmetry (HTI). Subjecting to HTI, physical properties vary in azimuth. P-wave reflection amplitude, which is susceptible to vary in azimuth, is one of the most popular seismic attributes which is widely used to delineate the fracture strike of an SAVF reservoir. Instead of going further on analyzing P-wave signatures, in this study, we focused on evaluating the feasibility of orienting the fracture strike of an SAVF reservoir using converted (C-) wave amplitude. For a C-wave is initiated by a downward traveling P-wave that is converted on reflection to an upcoming S-wave; the behaviors of both P- and S-waves should be theoretically woven in a C-wave. In our laboratory work, finite offset reflection experiments were carried out on the azimuthal plane of a HTI model at two different offset intervals. To demonstrate the azimuthal variation of C-wave amplitude in a HTI model, reflections were acquired along the principal symmetry directions and the diagonal direction of the HTI model. Inheriting from phenomenon of S-wave splitting in a transversely isotropic medium (TIM), P-waves get converted into both the fast (S1) and slow (S2) shear modes at all azimuths outside the vertical symmetry planes, thus producing split PS-waves (PS1 and PS2). In our laboratory data, the converted PS1- (C1-) wave were observed and identified. As the azimuth varies from the strike direction to the strike normal, C1-wave amplitude exhibits itself in a way of weakening and can be view from the common-reflection-point (CRP) gathers. Therefore, in conjunction with the azimuthal velocity and the amplitude variations in the P-wave and the azimuthal polarization of the S-wave, the azimuthal variation of C-wave amplitude which is experimentally demonstrated could be considered as a valuable seismic attribute in orienting the fracture strike of a SAVF reservoir. (Key words: converted wave, transversely isotropic medium, physical modeling, amplitude, fracture)

Fluoropyrimidine and platinum toxicity pharmacogenetics: an umbrella review of systematic reviews and meta-analyses.

PubMed

Campbell, Jared M; Bateman, Emma; Peters, Micah Dj; Bowen, Joanne M; Keefe, Dorothy M; Stephenson, Matthew D

2016-03-01

Fluoropyrimidine (FU) and platinum-based chemotherapies are greatly complicated by their associated toxicities. This umbrella systematic review synthesized all systematic reviews that investigated associations between germline variations and toxicity, with the aim of informing personalized medicine. Systematic reviews are important in pharmacogenetics where false positives are common. Four systematic reviews were identified for FU-induced toxicity and three for platinum. Polymorphisms of DPYD and TYMS, but not MTHFR, were statistically significantly associated with FU-induced toxicity (although only DPYD had clinical significance). For platinum, GSTP1 was found to not be associated with toxicity. This umbrella systematic review has synthesized the best available evidence on the pharmacogenetics of FU and platinum toxicity. It provides a useful reference for clinicians and identifies important research gaps.

Within-individual variation in bullfrog vocalizations: implications for a vocally mediated social recognition system.

PubMed

Bee, Mark A

2004-12-01

Acoustic signals provide a basis for social recognition in a wide range of animals. Few studies, however, have attempted to relate the patterns of individual variation in signals to behavioral discrimination thresholds used by receivers to discriminate among individuals. North American bullfrogs (Rana catesbeiana) discriminate among familiar and unfamiliar individuals based on individual variation in advertisement calls. The sources, patterns, and magnitudes of variation in eight acoustic properties of multiple-note advertisement calls were examined to understand how patterns of within-individual variation might either constrain, or provide additional cues for, vocal recognition. Six of eight acoustic properties exhibited significant note-to-note variation within multiple-note calls. Despite this source of within-individual variation, all call properties varied significantly among individuals, and multivariate analyses indicated that call notes were individually distinct. Fine-temporal and spectral call properties exhibited less within-individual variation compared to gross-temporal properties and contributed most toward statistically distinguishing among individuals. Among-individual differences in the patterns of within-individual variation in some properties suggest that within-individual variation could also function as a recognition cue. The distributions of among-individual and within-individual differences were used to generate hypotheses about the expected behavioral discrimination thresholds of receivers.

Employment Interventions for Return to Work in Working Aged Adults Following Traumatic Brain Injury (TBI): A Systematic Review. Campbell Systematic Reviews 2016:6

ERIC Educational Resources Information Center

Graham, Carolyn W.; West, Michael D.; Bourdon, Jessica L.; Inge, Katherine J.; Seward, Hannah E.

2016-01-01

Individuals with traumatic brain injury (TBI) often struggle to obtain competitive employment after sustaining a TBI, commonly as a result of the post-injury difficulties they exhibit (Andelic, Stevens, Sigurdardottir, Arango-Lasprilla, & Roe, 2009; Mansfield et al., 2015). The currently reported unemployment rate for people with TBI is…

Structural diversity in multinuclear Pd(II) assemblies that show low-humidity proton conduction.

PubMed

Samanta, Dipak; Mukherjee, Partha Sarathi

2014-05-05

Systematic investigation on synergetic effects of geometry, length, denticity, and asymmetry of donors was performed through the formation of a series of uncommon Pd(II) aggregates by employing the donor in a multicomponent self-assembly of a cis-blocked 90° Pd(II) acceptor and a tetratopic donor. Some of these assemblies represent the first examples of these types of structures, and their formation is not anticipated by only taking the geometry of the donor and the acceptor building units into account. Analysis of the crystal packing of the X-ray structure revealed several H bonds between the counteranions (NO3 (-) ) and water molecules (OH⋅⋅⋅ON). Moreover, H-bonded 3D-networks of water are present in the molecular pockets, which show water-adsorption properties with some variation in water affinity. Interestingly, these complexes exhibit proton conductivity (1.87×10(-5) -6.52×10(-4)  Scm(-1) ) at 296 K and low relative humidity (ca. 46 %) with activation energies of 0.29-0.46 eV. Moreover, the conductivities further increase with the enhancement of humidity. The ability of these assemblies to exhibit proton-conducting properties under low-humidity conditions makes these materials highly appealing as electrolytes in batteries and in fuel-cell applications. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Synthesis and characterization of AlTiSiN/CrSiN multilayer coatings by cathodic arc ion-plating

NASA Astrophysics Data System (ADS)

Yang, B.; Tian, C. X.; Wan, Q.; Yan, S. J.; Liu, H. D.; Wang, R. Y.; Li, Z. G.; Chen, Y. M.; Fu, D. J.

2014-09-01

AlTiSiN/CrSiN multilayer coatings were deposited on Si (1 0 0) and cemented carbide substrates using Cr, AlTi cathodes and SiH4 gases by cathodic arc ion plating system. The influences of SiH4 gases flowrate on the structural and mechanical properties of the coatings were investigated, systematically. AlTiSiN/CrSiN coatings exhibit a B1 NaCl-type nano-multilayered structure in which the CrSiN nano-layers alternate with AlTiSiN nano-layers with multiple orientations of crystal planes indicated by XRD patterns and TEM. Si contents of the coatings increase with increasing SiH4 flowrate. The hardness of the coatings increases to the maximum value of 3500 Hv0.05 with increasing SiH4 flowrate from 20 to 40 sccm and then decreases with further addition of SiH4 gases. A higher adhesive force of 73 N is obtained at the flowrate of 48 sccm. The coatings exhibit different tribological performance when the mating materials were varied from Si3N4 to cemented carbide balls and the variation of friction coefficients of the coatings against Si3N4 influenced by SiH4 flowrate are not obvious as against cemented carbide balls.

Electrical and thermal transport in doped barium plumbate

NASA Astrophysics Data System (ADS)

Eufrasio, Andreza; Pegg, Ian; Dutta, Biprodas

Thermoelectric (TE) power is generated by utilizing a temperature differential created across a material. Such energy conversion takes place without the incorporation of any moving part and can often lead to substantial recovery of waste heat into useful electrical energy. Ceramic oxides have gained attention as a new class of TE materials because of their high stability at elevated temperatures, where higher conversion efficiencies are expected. The present investigation uses Barium plumbate (BaPbO3) as the starting material, the TE properties of which have been altered by reasonable cation substitutions. As BaPbO3 has high electrical conductivity, σ 1.1x105Ω-1 m-1at room temperature, its thermopower, S, is relatively low 21 μV/K. With a thermal conductivity, k, of 3.00W/m.K, the figure of merit (ZT =S2 σ Tk-1) of BaPbO3\\ is 0.01 at T = 300 K. BaPbO3\\ is a prospective TE material because it exhibits high electrical conductivity like metals. However, it exhibits remarkably low thermal conductivity, which renders it attractive TE qualities. The open perovskite structure of BaPbO3\\ allows it to accommodate a large variety of dopants in relatively large concentrations. This work investigates the variation of TE properties of BaPbO3\\ as Ba ions are systematically substituted by other cations.

Investigating systematic individual differences in sleep-deprived performance on a high-fidelity flight simulator.

PubMed

Van Dongen, Hans P A; Caldwell, John A; Caldwell, J Lynn

2006-05-01

Laboratory research has revealed considerable systematic variability in the degree to which individuals' alertness and performance are affected by sleep deprivation. However, little is known about whether or not different populations exhibit similar levels of individual variability. In the present study, we examined individual variability in performance impairment due to sleep loss in a highly select population of militaryjet pilots. Ten active-duty F-117 pilots were deprived of sleep for 38 h and studied repeatedly in a high-fidelity flight simulator. Data were analyzed with a mixed-model ANOVA to quantify individual variability. Statistically significant, systematic individual differences in the effects of sleep deprivation were observed, even when baseline differences were accounted for. The findings suggest that highly select populations may exhibit individual differences in vulnerability to performance impairment from sleep loss just as the general population does. Thus, the scientific and operational communities' reliance on group data as opposed to individual data may entail substantial misestimation of the impact of job-related stressors on safety and performance.

Systematic Serendipity: A Method to Discover the Anomalous

NASA Astrophysics Data System (ADS)

Giles, Daniel; Walkowicz, Lucianne

2018-01-01

One of the challenges in the era of big data astronomical surveys is identifying anomalous data, data that exhibits as-of-yet unobserved behavior. These data may result from systematic errors, extreme (or rare) forms of known phenomena, or, most interestingly, truly novel phenomena that has historically required a trained eye and often fortuitous circumstance to identify. We describe a method that uses machine clustering techniques to discover anomalous data in Kepler lightcurves, as a step towards systematizing the detection of novel phenomena in the era of LSST. As a proof of concept, we apply our anomaly detection method to Kepler data including Boyajian's Star (KIC 8462852). We examine quarters 4, 8, 11, and 16 of the Kepler data which contain Boyajian’s Star acting normally (quarters 4 and 11) and anomalously (quarters 8 and 16). We demonstrate that our method is capable of identifying Boyajian’s Star’s anomalous behavior in quarters of interest, and we further identify other anomalous light curves that exhibit a range of interesting variability.

The nature of noise wavefield and its applications for site effects studies: A literature review

NASA Astrophysics Data System (ADS)

Bonnefoy-Claudet, Sylvette; Cotton, Fabrice; Bard, Pierre-Yves

2006-12-01

The aim of this paper is to discuss the existing scientific literature in order to gather all the available information dealing with the origin and the nature of the ambient seismic noise wavefield. This issue is essential as the use of seismic noise is more and more popular for seismic hazard purposes with a growing number of processing techniques based on the assumption that the noise wavefield is predominantly consisting of fundamental mode Rayleigh waves. This survey reveals an overall agreement about the origin of seismic noise and its frequency dependence. At frequencies higher than 1 Hz, seismic noise systematically exhibits daily and weekly variations linked to human activities, whereas at lower frequencies (between 0.005 and 0.3 Hz) the variation of seismic noise is correlated to natural activities (oceanic, meteorological…). Such a surface origin clearly supports the interpretation of seismic noise wavefield consisting primarily of surface waves. However, the further, very common (though hidden) assumption according which almost all the noise energy would be carried by fundamental mode Rayleigh waves is not supported by the few available data: no "average" number can though be given concerning the actual proportion between surface and body waves, Love and Rayleigh waves (horizontal components), fundamental and higher modes (vertical components), since the few available investigations report a significant variability, which might be related with site conditions and noise source properties.

Variation in Optoelectronic Properties of Azo Dye-Sensitized TiO 2 Semiconductor Interfaces with Different Adsorption Anchors: Carboxylate, Sulfonate, Hydroxyl and Pyridyl Groups

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhang, Lei; Cole, Jacqueline M.; Dai, Chencheng

2014-05-28

The optoelectronic properties of four azo dye-sensitized TiO2 interfaces are systematically studied as a function of a changing dye anchoring group: carboxylate, sulfonate, hydroxyl, and pyridyl. The variation in optoelectronic properties of the free dyes and those in dye/TiO 2 nanocomposites are studied both experimentally and computationally, in the context of prospective dye-sensitized solar cell (DSSC) applications. Experimental UV/vis absorption spectroscopy, cyclic voltammetry, and DSSC device performance testing reveal a strong dependence on the nature of the anchor of the optoelectronic properties of these dyes, both in solution and as dye/TiO2 nanocomposites. First-principles calculations on both an isolated dye/TiO2 clustermore » model (using localized basis sets) and each dye modeled onto the surface of a 2D periodic TiO2 nanostructure (using plane wave basis sets) are presented. Detailed examination of these experimental and computational results, in terms of light harvesting, electron conversion and photovoltaic device performance characteristics, indicates that carboxylate is the best anchoring group, and hydroxyl is the worst, whereas sulfonate and pyridyl groups exhibit competing potential. Different sensitization solvents are found to affect critically the extent of dye adsorption achieved in the dye-sensitization of the TiO2 semiconductor, especially where the anchor is a pyridyl group.« less

Structural and magnetic properties of hexagonal Cr1-δTe films grown on CdTe(001) by molecular beam epitaxy

NASA Astrophysics Data System (ADS)

Kanazawa, Ken; Yamawaki, Kazuma; Sekita, Naoya; Nishio, Yôtarô; Kuroda, Shinji; Mitome, Masanori; Bando, Yoshio

2015-04-01

We investigated the structural and magnetic properties of Cr1-δTe thin films grown on CdTe(001) layers by molecular beam epitaxy (MBE) with systematic variations of the ratio between Cr and Te fluxes and the substrate temperature Ts during the growth. Cr1-δTe of the hexagonal structure (hex-Cr1-δTe) was always formed irrespective of the growth conditions, but the growth orientation was different depending on the Cr/Te flux ratio and Ts. Hex-Cr1-δTe was grown in the [0001] axis in the range of small Cr/Te ratios and high Ts while it was also grown in the direction normal to the (1-102) plane at larger Cr/Te ratios or lower Ts. Hex-Cr1-δTe films grown in the both orientations show ferromagnetism, but they exhibit a clear contrast in the field dependence of perpendicular magnetization at 2 K; a square hysteretic loop in the film grown in the [0001] axis versus a round-shape loop in the film grown in the direction normal to the (1-102) plane. Moreover, the films grown in the [0001] axis at the smallest Cr/Te ratio show variations of ferromagnetic properties with Curie temperature (Tc) and the coercivity (Hc) varying according to the value of Ts.

Matched Comparison Group Design Standards in Systematic Reviews of Early Childhood Interventions.

PubMed

Thomas, Jaime; Avellar, Sarah A; Deke, John; Gleason, Philip

2017-06-01

Systematic reviews assess the quality of research on program effectiveness to help decision makers faced with many intervention options. Study quality standards specify criteria that studies must meet, including accounting for baseline differences between intervention and comparison groups. We explore two issues related to systematic review standards: covariate choice and choice of estimation method. To help systematic reviews develop/refine quality standards and support researchers in using nonexperimental designs to estimate program effects, we address two questions: (1) How well do variables that systematic reviews typically require studies to account for explain variation in key child and family outcomes? (2) What methods should studies use to account for preexisting differences between intervention and comparison groups? We examined correlations between baseline characteristics and key outcomes using Early Childhood Longitudinal Study-Birth Cohort data to address Question 1. For Question 2, we used simulations to compare two methods-matching and regression adjustment-to account for preexisting differences between intervention and comparison groups. A broad range of potential baseline variables explained relatively little of the variation in child and family outcomes. This suggests the potential for bias even after accounting for these variables, highlighting the need for systematic reviews to provide appropriate cautions about interpreting the results of moderately rated, nonexperimental studies. Our simulations showed that regression adjustment can yield unbiased estimates if all relevant covariates are used, even when the model is misspecified, and preexisting differences between the intervention and the comparison groups exist.

An Exploration of the Importance of Flood Heterogeneity for Regionalization in Arizona using the Expected Moments Algorithm

NASA Astrophysics Data System (ADS)

Zamora-Reyes, D.; Hirschboeck, K. K.; Paretti, N. V.

2012-12-01

Bulletin 17B (B17B) has prevailed for 30 years as the standard manual for determining flood frequency in the United States. Recently proposed updates to B17B include revising the issue of flood heterogeneity, and improving flood estimates by using the Expected Moments Algorithm (EMA) which can better address low outliers and accommodate information on historical peaks. Incorporating information on mixed populations, such as flood-causing mechanisms, into flood estimates for regions that have noticeable flood heterogeneity can be statistically challenging when systematic flood records are short. The problem magnifies when the population sample size is reduced by decomposing the record, especially if multiple flood mechanisms are involved. In B17B, the guidelines for dealing with mixed populations focus primarily on how to rule out any need to perform a mixed-population analysis. However, in some regions mixed flood populations are critically important determinants of regional flood frequency variations and should be explored from this perspective. Arizona is an area with a heterogeneous mixture of flood processes due to: warm season convective thunderstorms, cool season synoptic-scale storms, and tropical cyclone-enhanced convective activity occurring in the late summer or early fall. USGS station data throughout Arizona was compiled into a database and each flood peak (annual and partial duration series) was classified according to its meteorological cause. Using these data, we have explored the role of flood heterogeneity in Arizona flood estimates through composite flood frequency analysis based on mixed flood populations using EMA. First, for selected stations, the three flood-causing populations were separated out from the systematic annual flood series record and analyzed individually. Second, to create composite probability curves, the individual curves for each of the three populations were generated and combined using Crippen's (1978) composite probability equations for sites that have two or more independent flood populations. Finally, the individual probability curves generated for each of the three flood-causing populations were compared with both the site's composite probability curve and the standard B17B curve to explore the influence of heterogeneity using the 100-year and 200-year flood estimates as a basis of comparison. Results showed that sites located in southern Arizona and along the abrupt elevation transition zone of the Mogollon Rim exhibit a better fit to the systematic data using their composite probability curves than the curves derived from standard B17B analysis. Synoptic storm floods and tropical cyclone-enhanced floods had the greatest influence on 100-year and 200-year flood estimates. This was especially true in southern Arizona, even though summer convective floods are much more frequent and therefore dominate the composite curve. Using the EMA approach also influenced our results because all possible low outliers were censored by the built-in Multiple Grubbs-Beck Test, providing a better fit to the systematic data in the upper probabilities. In conclusion, flood heterogeneity can play an important role in regional flood frequency variations in Arizona and that understanding its influence is important when making projections about future flood variations.

On the variability of alligator sex ratios

USGS Publications Warehouse

Nichols, J.D.; Chabreck, R.H.

1980-01-01

Samples of alligators from wild and 'farm' populations exhibited disproportionate sex ratios. Males predominated among young alligators from wild populations, whereas females were much more abundant than males in the farm population, where resources were superabundant. These results and other considerations lead us to hypothesize that environmental factors influence sex determination in alligators. During favorable environmental conditions natural selection is expected to favor a preponderance of the sex whose individuals exhibit the greater environmentally associated variation in relative fitness. We hypothesize that environmentally associated variation in age at sexual maturity of females produces sufficient variation in relative fitness of females to result in selection for low sex ratios during periods of resource abundance.

Correlation of process parameters and properties of TiO2 films grown by ion beam sputter deposition from a ceramic target

NASA Astrophysics Data System (ADS)

Bundesmann, Carsten; Lautenschläge, Thomas; Spemann, Daniel; Finzel, Annemarie; Mensing, Michael; Frost, Frank

2017-10-01

The correlation between process parameters and properties of TiO2 films grown by ion beam sputter deposition from a ceramic target was investigated. TiO2 films were grown under systematic variation of ion beam parameters (ion species, ion energy) and geometrical parameters (ion incidence angle, polar emission angle) and characterized with respect to film thickness, growth rate, structural properties, surface topography, composition, optical properties, and mass density. Systematic variations of film properties with the scattering geometry, namely the scattering angle, have been revealed. There are also considerable differences in film properties when changing the process gas from Ar to Xe. Similar systematics were reported for TiO2 films grown by reactive ion beam sputter deposition from a metal target [C. Bundesmann et al., Appl. Surf. Sci. 421, 331 (2017)]. However, there are some deviations from the previously reported data, for instance, in growth rate, mass density and optical properties.

Re-Os Systematics and HSE Distribution in Metal from Ochansk (H4) Chondrite

NASA Technical Reports Server (NTRS)

Smoliar, M. I.; Horan, M. F.; Alexander, C. M. OD.; Walker, R. J.

2003-01-01

Previous studies of the Re-Os systematics of chondrites have documented considerable variation in the Re/Os ratios of whole rock samples. For some whole rock chondrites, Re-Os systematics display large deviations from the primitive isochron that are considerably larger than deviations in other isotope systems. Possible interpretation of these facts is that the Re-Os system in chondrites is particularly sensitive to post-formation alteration processes, thus providing a useful tool to examine such processes. Significant variations that have been detected in highly siderophile element (HSE) patterns for ordinary chondrites support this conclusion. We report Re-Os isotope data for metal separates from the Ochansk H4 chondrite coupled with abundance data for Ru, Pd, Ir, and Pt, determined in the same samples by isotope dilution. We chose this meteorite mainly because it is an observed fall with minimal signs of weathering, and its low metamorphic grade (H4) and shock stage (S3).

Single-Blinded Prospective Implementation of a Preoperative Imaging Checklist for Endoscopic Sinus Surgery.

PubMed

Error, Marc; Ashby, Shaelene; Orlandi, Richard R; Alt, Jeremiah A

2018-01-01

Objective To determine if the introduction of a systematic preoperative sinus computed tomography (CT) checklist improves identification of critical anatomic variations in sinus anatomy among patients undergoing endoscopic sinus surgery. Study Design Single-blinded prospective cohort study. Setting Tertiary care hospital. Subjects and Methods Otolaryngology residents were asked to identify critical surgical sinus anatomy on preoperative CT scans before and after introduction of a systematic approach to reviewing sinus CT scans. The percentage of correctly identified structures was documented and compared with a 2-sample t test. Results A total of 57 scans were reviewed: 28 preimplementation and 29 postimplementation. Implementation of the sinus CT checklist improved identification of critical sinus anatomy from 24% to 84% correct ( P < .001). All residents, junior and senior, demonstrated significant improvement in identification of sinus anatomic variants, including those not directly included in the systematic review implemented. Conclusion The implementation of a preoperative endoscopic sinus surgery radiographic checklist improves identification of critical anatomic sinus variations in a training population.

Quantifying Proportional Variability

PubMed Central

Heath, Joel P.; Borowski, Peter

2013-01-01

Real quantities can undergo such a wide variety of dynamics that the mean is often a meaningless reference point for measuring variability. Despite their widespread application, techniques like the Coefficient of Variation are not truly proportional and exhibit pathological properties. The non-parametric measure Proportional Variability (PV) [1] resolves these issues and provides a robust way to summarize and compare variation in quantities exhibiting diverse dynamical behaviour. Instead of being based on deviation from an average value, variation is simply quantified by comparing the numbers to each other, requiring no assumptions about central tendency or underlying statistical distributions. While PV has been introduced before and has already been applied in various contexts to population dynamics, here we present a deeper analysis of this new measure, derive analytical expressions for the PV of several general distributions and present new comparisons with the Coefficient of Variation, demonstrating cases in which PV is the more favorable measure. We show that PV provides an easily interpretable approach for measuring and comparing variation that can be generally applied throughout the sciences, from contexts ranging from stock market stability to climate variation. PMID:24386334

The Adoption of Variation Theory in the Classroom: Effect on Students' Algebraic Achievement and Motivation to Learn

ERIC Educational Resources Information Center

Ting, Jing Jing; Tarmizi, Rohani Tarmizi; Bakar, Kamariah Abu; Aralas, Dalia

2017-01-01

Introduction: Analysis of lessons held in East Asia regions that perform well in Trends in International Mathematics and Science Studies such as; South Korea, Hong Kong and Japan, demonstrated teachers in mathematics classroom enacted features of the content systematically with consideration of variation within students' capabilities. Recent…

Systematic Convergence in Applying Variational Method to Double-Well Potential

ERIC Educational Resources Information Center

Mei, Wai-Ning

2016-01-01

In this work, we demonstrate the application of the variational method by computing the ground- and first-excited state energies of a double-well potential. We start with the proper choice of the trial wave functions using optimized parameters, and notice that accurate expectation values in excellent agreement with the numerical results can be…

Conceptual Variation or Incoherence? Textbook Discourse on Genes in Six Countries

ERIC Educational Resources Information Center

Gericke, Niklas M.; Hagberg, Mariana; dos Santos, Vanessa Carvalho; Joaquim, Leyla Mariane; El-Hani, Charbel N.

2014-01-01

The aim of this paper is to investigate in a systematic and comparative way previous results of independent studies on the treatment of genes and gene function in high school textbooks from six different countries. We analyze how the conceptual variation within the scientific domain of Genetics regarding gene function models and gene concepts is…

Irradiation-assisted stress corrosion cracking of model austenitic stainless steel.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chung, H. M.; Ruther, W. E.; Strain, R. V.

1999-10-26

Slow-strain-rate tensile (SSRT) tests were conducted on model austenitic stainless steel (SS) alloys that were irradiated at 289 C in He. After irradiation to {approx}0.3 x 10{sup 21} n {center_dot} cm{sup 2} and {approx} 0.9 x 10{sup 21} n {center_dot} cm{sup -2} (E > 1 MeV), significant heat-to-heat variations in the degree of intergranular and transgranular stress corrosion cracking (IGSCC and TGSCC) were observed. At {approx}0.3 x 10{sup 21} n {center_dot} cm{sup -2}, a high-purity heat of Type 316L SS that contains a very low concentration of Si exhibited the highest susceptibility to IGSCC. In unirradiated state, Types 304 andmore » 304L SS did not exhibit a systematic effect of Si content on alloy strength. However, at {approx}0.3 x 10{sup 21} n {center_dot} cm{sup -2}, yield and maximum strengths decreased significantly as Si content was increased to >0.9 wt.%. Among alloys that contain low concentrations of C and N, ductility and resistance to TGSCC and IGSCC were significantly greater for alloys with >0.9 wt.% Si than for alloys with <0.47 wt.% Si. Initial data at {approx}0.9 x 10{sup 21} n {center_dot} cm{sup -2} were also consistent with the beneficial effect of high Si content. This indicates that to delay onset of and reduce susceptibility to irradiation-assisted stress corrosion cracking (IASCC), at least at low fluence levels, it is helpful to ensure a certain minimum concentration of Si. High concentrations of Cr were also beneficial; alloys that contain <15.5 wt.% Cr exhibited greater susceptibility to IASCC than alloys with {approx}18 wt.% Cr, whereas an alloy that contains >21 wt.% Cr exhibited less susceptibility than the lower-Cr alloys under similar conditions.« less

Ligand-controlled assembly of Cd(II) coordination polymers based on mixed ligands of naphthalene-dicarboxylate and dipyrido[3,2-d:2',3'-f]quinoxaline: From 0D+1D cocrystal, 2D rectangular network (4,4), to 3D PtS-type architecture

DOE Office of Scientific and Technical Information (OSTI.GOV)

Liu Guocheng; Chen Yongqiang; Wang Xiuli

Three novel Cd(II) coordination polymers, namely, [Cd(Dpq)(1,8-NDC)(H{sub 2}O){sub 2}][Cd(Dpq)(1,8-NDC)].2H{sub 2}O (1), [Cd(Dpq)(1,4-NDC)(H{sub 2}O)] (2), and [Cd(Dpq)(2,6-NDC)] (3) have been obtained from hydrothermal reactions of cadmium(II) nitrate with the mixed ligands dipyrido [3,2-d:2',3'-f]quinoxaline (Dpq) and three structurally related naphthalene-dicarboxylate ligands [1,8-naphthalene-dicarboxylic acid (1,8-H{sub 2}NDC), 1,4-naphthalene-dicarboxylic acid (1,4-H{sub 2}NDC), and 2,6-naphthalene-dicarboxylic acid (2,6-H{sub 2}NDC)]. Single-crystal X-ray diffraction analysis reveals that the three polymers exhibit novel structures due to different naphthalene-dicarboxylic acid. Compound 1 is a novel cocrystal of left- and right-handed helical chains and binuclear complexes and ultimately packed into a 3D supramolecular structure through hydrogen bonds and {pi}-{pi} stacking interactions. Compoundmore » 2 shows a 2D rectangular network (4,4) bridged by 1,4-NDC with two kinds of coordination modes and ultimately packed into a 3D supramolecular structure through inter-layer {pi}-{pi} stacking interactions. Compound 3 is a new 3D coordination polymer with distorted PtS-type network. In addition, the title compounds exhibit blue/green emission in solid state at room temperature. - Graphical abstract: Three novel Cd(II) compounds have been synthesized under hydrothermal conditions exhibiting a systematic variation of architecture by the employment of three structurally related naphthalene-dicarboxylate ligands.« less

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ravikumar, Patta; Kisan, Bhagaban; Perumal, A., E-mail: perumal@iitg.ernet.in

We report systematic investigations of structural, vibrational, resonance and magnetic properties of nanoscale NiO powders prepared by ball milling process under different milling speeds for 30 hours of milling. Structural properties revealed that both pure NiO and as-milled NiO powders exhibit face centered cubic structure, but average crystallite size decreases to around 11 nm along with significant increase in strain with increasing milling speed. Vibrational properties show the enhancement in the intensity of one-phonon longitudinal optical (LO) band and disappearance of two-magnon band due to size reduction. In addition, two-phonon LO band exhibits red shift due to size-induced phonon confinementmore » effect and surface relaxation. Pure NiO powder exhibit antiferromagnetic nature, which transforms into induced ferromagnetic after size reduction. The average magnetization at room temperature increases with decreasing the crystallite size and a maximum moment of 0.016 μ{sub B}/f.u. at 12 kOe applied field and coercivity of 170 Oe were obtained for 30 hours milled NiO powders at 600 rotation per minute milling speed. The change in the magnetic properties is also supported by the vibrational properties. Thermomagnetization measurements at high temperature reveal a well-defined magnetic phase transition at high temperature (T{sub C}) around 780 K due to induced ferromagnetic phase. Electron paramagnetic resonance (EPR) studies reveal a good agreement between the EPR results and magnetic properties. The observed results are described on the basis of crystallite size variation, defect density, large strain, oxidation/reduction of Ni and interaction between uncompensated surfaces and particle core with lattice expansion. The obtained results suggest that nanoscale NiO powders with high T{sub C} and moderate magnetic moment at room temperature with cubic structure would be useful to expedite for spintronic devices.« less

Aridity increases below-ground niche breadth in grass communities

USGS Publications Warehouse

Butterfield, Bradley J.; Bradford, John B.; Munson, Seth M.; Gremer, Jennifer R.

2017-01-01

Aridity is an important environmental filter in the assembly of plant communities worldwide. The extent to which root traits mediate responses to aridity, and how they are coordinated with leaf traits, remains unclear. Here, we measured variation in root tissue density (RTD), specific root length (SRL), specific leaf area (SLA), and seed size within and among thirty perennial grass communities distributed along an aridity gradient spanning 190–540 mm of climatic water deficit (potential minus actual evapotranspiration). We tested the hypotheses that traits exhibited coordinated variation (1) among species, as well as (2) among communities varying in aridity, and (3) functional diversity within communities declines with increasing aridity, consistent with the “stress-dominance” hypothesis. Across communities, SLA and RTD exhibited a coordinated response to aridity, shifting toward more conservative (lower SLA, higher RTD) functional strategies with increasing aridity. The response of SRL to aridity was more idiosyncratic and was independent of variation in SLA and RTD. Contrary to the stress-dominance hypothesis, the diversity of SRL values within communities increased with aridity, while none of the other traits exhibited significant diversity responses. These results are consistent with other studies that have found SRL to be independent of an SLA–RTD axis of functional variation and suggest that the dynamic nature of soil moisture in arid environments may facilitate a wider array of resource capture strategies associated with variation in SRL.

A systematic review of global cultural variations in knowledge, attitudes and health responses to tuberculosis stigma.

PubMed

Chang, S-H; Cataldo, J K

2014-02-01

Tuberculosis (TB) related stigma is associated with lack of treatment adherence. Individual perceptions of stigma differ by societal context. Limited data are available on variations of TB stigma worldwide. To describe the influence of TB stigma on knowledge, attitudes and responses to TB and to identify similarities and differences across countries. Systematic review of international descriptive studies. A total of 1268 studies were identified from PubMed/Medline, Web of Science, Cochrane, PsycINFO and Cumulative Index to Nursing and Allied Health Literature database searches. Eighty-three studies from 35 countries met the inclusion criteria for English, peer-reviewed, original and non-interventional studies. Variation and similarities in the influence of TB stigma on knowledge, attitudes and responses to TB across countries were identified. Stigma antecedents included negative attitudes and misperceptions regarding the causes of TB and the association with the human immunodeficiency virus. Decisions about illness disclosure and choices between traditional healers and public or private providers were influenced by TB stigma. Sex-influenced perceptions and management of TB and public health responses contributed to TB stigma. Our findings confirm cultural variations with respect to TB and the potential for stigma. Cultural variations should be considered in the development of interventions aimed at reducing stigma and improving treatment adherence.

Statistical metrology—measurement and modeling of variation for advanced process development and design rule generation

NASA Astrophysics Data System (ADS)

Boning, Duane S.; Chung, James E.

1998-11-01

Advanced process technology will require more detailed understanding and tighter control of variation in devices and interconnects. The purpose of statistical metrology is to provide methods to measure and characterize variation, to model systematic and random components of that variation, and to understand the impact of variation on both yield and performance of advanced circuits. Of particular concern are spatial or pattern-dependencies within individual chips; such systematic variation within the chip can have a much larger impact on performance than wafer-level random variation. Statistical metrology methods will play an important role in the creation of design rules for advanced technologies. For example, a key issue in multilayer interconnect is the uniformity of interlevel dielectric (ILD) thickness within the chip. For the case of ILD thickness, we describe phases of statistical metrology development and application to understanding and modeling thickness variation arising from chemical-mechanical polishing (CMP). These phases include screening experiments including design of test structures and test masks to gather electrical or optical data, techniques for statistical decomposition and analysis of the data, and approaches to calibrating empirical and physical variation models. These models can be integrated with circuit CAD tools to evaluate different process integration or design rule strategies. One focus for the generation of interconnect design rules are guidelines for the use of "dummy fill" or "metal fill" to improve the uniformity of underlying metal density and thus improve the uniformity of oxide thickness within the die. Trade-offs that can be evaluated via statistical metrology include the improvements to uniformity possible versus the effect of increased capacitance due to additional metal.

Sexual selection and the rodent baculum: an intraspecific study in the house mouse (Mus musculus domesticus).

PubMed

Ramm, Steven A; Khoo, Lin; Stockley, Paula

2010-01-01

The rapid divergence of genitalia is a pervasive trend in animal evolution, thought to be due to the action of sexual selection. To test predictions from the sexual selection hypothesis, we here report data on the allometry, variation, plasticity and condition dependence of baculum morphology in the house mouse (Mus musculus domesticus). We find that that baculum size: (a) exhibits no consistent pattern of allometric scaling (baculum size being in most cases unrelated to body size), (b) exhibits low to moderate levels of phenotypic variation, (c) does not exhibit phenotypic plasticity in response to differences in perceived levels of sexual competition and (d) exhibits limited evidence of condition dependence. These patterns provide only limited evidence in support of the sexual selection hypothesis, and no consistent support for any particular sexual selection mechanism; however, more direct measures of how genital morphology influences male fertilization success are required.

Amine-functionalized mesoporous polymer as potential sorbent for nickel preconcentration from electroplating wastewater.

PubMed

Islam, Aminul; Zaidi, Noushi; Ahmad, Hilal; Kumar, Suneel

2015-05-01

In this study, mesoporous glycidyl methacrylate-divinylbenzene-based chelating resin was synthesized and grafted with diethylenetriamine through epoxy ring-opening reaction. The synthesized resin was characterized by elemental analysis, infrared spectroscopy, surface area and pore size analysis, scanning electron microscopy, energy-dispersive spectroscopy, and thermogravimetry. The resin was used for the first time as an effective sorbent for the preconcentration of nickel in electroplating wastewater samples. The analytical variables like pH, flow rate for sorption/desorption, and eluate selection were systematically investigated and optimized. The uniform and monolayer sorption behavior of resin for nickel was proved by an evident fit of the equilibrium data to a Langmuir isotherm model. Under optimized conditions, the resin was observed to show a good sorption capacity of 20.25 mg g(-1) and >96% recovery of nickel even in the presence of a large number of competitive matrix ions. Its ability to extract trace amount of nickel was exhibited by low preconcentration limit (5.9 μg L(-1)). The calibration curve was found to be linear (R(2) = 0.998) in the concentration range of 6.0-400.0 μg L(-1). Coefficient of variation of less than 5 for all the analysis indicated good reproducibility. The reliability was evaluated by the analysis of standard reference material (SRM) and recovery experiments. The applicability of the resin for the systematic preconcentration of nickel is substantiated by the analysis of electroplating wastewater and river water samples. Graphical abstract ᅟ.

Relaxed selection on the CBF/DREB1 regulatory genes and reduced freezing tolerance in the southern range of Arabidopsis thaliana.

PubMed

Zhen, Ying; Ungerer, Mark C

2008-12-01

Elucidating the molecular basis of adaptive phenotypic variation represents a central aim in evolutionary biology. Traits exhibiting patterns of clinal variation represent excellent models for studies of molecular adaptation, especially when variation in phenotype can be linked to organismal fitness in different environments. Natural accessions of the model plant species Arabidopsis thaliana exhibit clinal variation in freezing tolerance that follows a gradient of temperature variability across the species' native range (Zhen Y, Ungerer MC. 2008. Clinal variation in freezing tolerance among natural accessions of A. thaliana. New Phytol. 177:419-427). Here, we report that this pattern of variation is attributable, at least in part, to relaxed purifying selection on members of a small family of transcriptional activators (the CBF/DREB1s) in the species' southern range. These regulatory genes play a critical role in the ability of A. thaliana plants to undergo cold acclimation and thereby achieve maximum freezing tolerance. Relative to accessions from northern regions, accessions of A. thaliana from the southern part of their geographic range exhibit levels of nonsynonymous nucleotide polymorphism that are approximately 2.8-fold higher across this small gene subfamily. Relaxed selection on the CBF/DREB1s in southern accessions also has resulted in multiple mutations in regulatory regions resulting in abrogated expression of particular subfamily members in particular accessions. These coding-region and regulatory mutations compromise the ability of these genes to act as efficient transcriptional activators during the cold acclimation process, as determined by reductions in rates of induction and maximum levels of expression in the downstream genes they regulate. This study highlights the potential role of regulatory genes in underlying adaptive phenotypic variation in nature.

The match-to-match variation of match-running in elite female soccer.

PubMed

Trewin, Joshua; Meylan, César; Varley, Matthew C; Cronin, John

2018-02-01

The purpose of this study was to examine the match-to-match variation of match-running in elite female soccer players utilising GPS, using full-match and rolling period analyses. Longitudinal study. Elite female soccer players (n=45) from the same national team were observed during 55 international fixtures across 5 years (2012-2016). Data was analysed using a custom built MS Excel spreadsheet as full-matches and using a rolling 5-min analysis period, for all players who played 90-min matches (files=172). Variation was examined using co-efficient of variation and 90% confidence limits, calculated following log transformation. Total distance per minute exhibited the smallest variation when both the full-match and peak 5-min running periods were examined (CV=6.8-7.2%). Sprint-efforts were the most variable during a full-match (CV=53%), whilst high-speed running per minute exhibited the greatest variation in the post-peak 5-min period (CV=143%). Peak running periods were observed as slightly more variable than full-match analyses, with the post-peak period very-highly variable. Variability of accelerations (CV=17%) and Player Load (CV=14%) was lower than that of high-speed actions. Positional differences were also present, with centre backs exhibiting the greatest variation in high-speed movements (CV=41-65%). Practitioners and researchers should account for within player variability when examining match performances. Identification of peak running periods should be used to assist worst case scenarios. Whilst micro-sensor technology should be further examined as to its viable use within match-analyses. Copyright © 2017 Sports Medicine Australia. Published by Elsevier Ltd. All rights reserved.

Environmental characteristics drive variation in Amazonian understorey bird assemblages

PubMed Central

Magnusson, William E.; Anderson, Marti J.; Schlegel, Martin; Pe’er, Guy; Henle, Klaus

2017-01-01

Tropical bird assemblages display patterns of high alpha and beta diversity and, as tropical birds exhibit strong habitat specificity, their spatial distributions are generally assumed to be driven primarily by environmental heterogeneity and interspecific interactions. However, spatial distributions of some Amazonian forest birds are also often restricted by large rivers and other large-scale topographic features, suggesting that dispersal limitation may also play a role in driving species’ turnover. In this study, we evaluated the effects of environmental characteristics, topographic and spatial variables on variation in local assemblage structure and diversity of birds in an old-growth forest in central Amazonia. Birds were mist-netted in 72 plots distributed systematically across a 10,000 ha reserve in each of three years. Alpha diversity remained stable through time, but species composition changed. Spatial variation in bird-assemblage structure was significantly related to environmental and topographic variables but not strongly related to spatial variables. At a broad scale, we found bird assemblages to be significantly distinct between two watersheds that are divided by a central ridgeline. We did not detect an effect of the ridgeline per se in driving these patterns, indicating that most birds are able to fly across it, and that differences in assemblage structure between watersheds may be due to unmeasured environmental variables or unique combinations of measured variables. Our study indicates that complex geography and landscape features can act together with environmental variables to drive changes in the diversity and composition of tropical bird assemblages at local scales, but highlights that we still know very little about what makes different parts of tropical forest suitable for different species. PMID:28225774

Breakup of a liquid rivulet falling over an inclined plate: Identification of a critical Weber number

DOE Office of Scientific and Technical Information (OSTI.GOV)

Singh, Rajesh K.; Galvin, Janine E.; Whyatt, Greg A.

Here, we have numerically investigated the breakup of a rivulet falling over a smooth inclined plate using the volume of fluid method. The breakup the rivulet is a complex phenomenon that is dictated by many factors, such as solvent properties, contact angle, inertia, plate inclination, etc. An extensive simulation campaign was conducted wherein these factors were systematically investigated. Regimes for a stable rivulet and an unstable rivulet that leads to the breakup and formation of a droplet are examined in terms of a critical value of the Weber number (We cr) that delineates these regimes. The effect of plate inclinationmore » on the breakup of the rivulet shows that the critical Weber number decreases with increased inclination angle (θ) owing to higher liquid velocity. However, the effect is negligible beyond θ > 60°. The impact of solvent properties is characterized using the Kapitza number (Ka). Variation of We cr with Ka shows two trends depending on the Ka value of the solvent. Solvents with lower Ka values, corresponding to high viscosities and/or low surface tensions, show smaller values of the critical Weber number and the variation is linear. While solvents with higher Ka values exhibit higher values of the We cr and the variation in We cr is steep. This behavior is more pronounced with increasing contact angle. Higher contact angles promote rivulet breakup so that inertia must be higher to the breakup. As a result, a phenomenological scaling for a critical Weber number with the Kapitza number and contact angle is presented that can offer insight into rivulet breakup.« less

Breakup of a liquid rivulet falling over an inclined plate: Identification of a critical Weber number

DOE PAGES

Singh, Rajesh K.; Galvin, Janine E.; Whyatt, Greg A.; ...

2017-05-04

Here, we have numerically investigated the breakup of a rivulet falling over a smooth inclined plate using the volume of fluid method. The breakup the rivulet is a complex phenomenon that is dictated by many factors, such as solvent properties, contact angle, inertia, plate inclination, etc. An extensive simulation campaign was conducted wherein these factors were systematically investigated. Regimes for a stable rivulet and an unstable rivulet that leads to the breakup and formation of a droplet are examined in terms of a critical value of the Weber number (We cr) that delineates these regimes. The effect of plate inclinationmore » on the breakup of the rivulet shows that the critical Weber number decreases with increased inclination angle (θ) owing to higher liquid velocity. However, the effect is negligible beyond θ > 60°. The impact of solvent properties is characterized using the Kapitza number (Ka). Variation of We cr with Ka shows two trends depending on the Ka value of the solvent. Solvents with lower Ka values, corresponding to high viscosities and/or low surface tensions, show smaller values of the critical Weber number and the variation is linear. While solvents with higher Ka values exhibit higher values of the We cr and the variation in We cr is steep. This behavior is more pronounced with increasing contact angle. Higher contact angles promote rivulet breakup so that inertia must be higher to the breakup. As a result, a phenomenological scaling for a critical Weber number with the Kapitza number and contact angle is presented that can offer insight into rivulet breakup.« less

Chromosomal Copy Number Variation in Saccharomyces pastorianus Is Evidence for Extensive Genome Dynamics in Industrial Lager Brewing Strains.

PubMed

van den Broek, M; Bolat, I; Nijkamp, J F; Ramos, E; Luttik, M A H; Koopman, F; Geertman, J M; de Ridder, D; Pronk, J T; Daran, J-M

2015-09-01

Lager brewing strains of Saccharomyces pastorianus are natural interspecific hybrids originating from the spontaneous hybridization of Saccharomyces cerevisiae and Saccharomyces eubayanus. Over the past 500 years, S. pastorianus has been domesticated to become one of the most important industrial microorganisms. Production of lager-type beers requires a set of essential phenotypes, including the ability to ferment maltose and maltotriose at low temperature, the production of flavors and aromas, and the ability to flocculate. Understanding of the molecular basis of complex brewing-related phenotypic traits is a prerequisite for rational strain improvement. While genome sequences have been reported, the variability and dynamics of S. pastorianus genomes have not been investigated in detail. Here, using deep sequencing and chromosome copy number analysis, we showed that S. pastorianus strain CBS1483 exhibited extensive aneuploidy. This was confirmed by quantitative PCR and by flow cytometry. As a direct consequence of this aneuploidy, a massive number of sequence variants was identified, leading to at least 1,800 additional protein variants in S. pastorianus CBS1483. Analysis of eight additional S. pastorianus strains revealed that the previously defined group I strains showed comparable karyotypes, while group II strains showed large interstrain karyotypic variability. Comparison of three strains with nearly identical genome sequences revealed substantial chromosome copy number variation, which may contribute to strain-specific phenotypic traits. The observed variability of lager yeast genomes demonstrates that systematic linking of genotype to phenotype requires a three-dimensional genome analysis encompassing physical chromosomal structures, the copy number of individual chromosomes or chromosomal regions, and the allelic variation of copies of individual genes. Copyright © 2015, van den Broek et al.

Inorganic anion-dependent assembly of zero-, one-, two- and three-dimensional Cu(II)/Ag(I) complexes under the guidance of the HSAB theory: Synthesis, structure, and magnetic property

DOE Office of Scientific and Technical Information (OSTI.GOV)

Liu, Yaru; Xing, Zhiyan; Zhang, Xiao

To systematically explore the influence of inorganic anions on building coordination complexes, five novel complexes based on 1-(benzotriazole-1-methyl)−2-propylimidazole (bpmi), [Cu(bpmi){sub 2}(Ac){sub 2}]·H{sub 2}O (1), [Cu(bpmi){sub 2}(H{sub 2}O){sub 2}]·2NO{sub 3}·2H{sub 2}O (2), [Cu(bpmi)(N{sub 3}){sub 2}] (3), [Ag(bpmi)(NO{sub 3})] (4) and [Cu{sub 3}(bpmi){sub 2}(SCN){sub 4}(DMF)] (5) (Ac{sup −}=CH{sub 3}COO{sup −}, DMF=N,N-Dimethylformamide) are synthesized through rationally introducing Cu(II) salts and Ag(I) salt with different inorganic anions. X-ray single-crystal analyses reveal that these complexes show interesting structural features from mononuclear (1), one-dimensional (2 and 3), two-dimensional (4) to three-dimensional (5) under the influence of inorganic anions with different basicities. The structural variation can bemore » explained by the hard-soft-acid-base (HSAB) theory. Magnetic susceptibility measurement indicates that complex 3 exhibits an antiferromagnetic coupling between adjacent Cu(II) ions. - Graphical abstract: Five new Cu(II)/Ag(I) complexes show interesting structural features from mononuclear, one-dimension, two-dimension to three-dimension under the influence of inorganic anions. The structural variation can be explained by the HSAB theory. - Highlights: • Five inorganic anion-dependent complexes are synthesized. • Structural variation can be explained by the hard-soft-acid-base (HSAB) theory. • The magnetic property of complex has been studied.« less

Study of magnetism in Ni-Cr hardface alloy deposit on 316LN stainless steel using magnetic force microscopy

NASA Astrophysics Data System (ADS)

Kishore, G. V. K.; Kumar, Anish; Chakraborty, Gopa; Albert, S. K.; Rao, B. Purna Chandra; Bhaduri, A. K.; Jayakumar, T.

2015-07-01

Nickel base Ni-Cr alloy variants are extensively used for hardfacing of austenitic stainless steel components in sodium cooled fast reactors (SFRs) to avoid self-welding and galling. Considerable difference in the compositions and melting points of the substrate and the Ni-Cr alloy results in significant dilution of the hardface deposit from the substrate. Even though, both the deposit and the substrate are non-magnetic, the diluted region exhibits ferromagnetic behavior. The present paper reports a systematic study carried out on the variations in microstructures and magnetic behavior of American Welding Society (AWS) Ni Cr-C deposited layers on 316 LN austenitic stainless steels, using atomic force microscopy (AFM) and magnetic force microscopy (MFM). The phase variations of the oscillations of a Co-Cr alloy coated magnetic field sensitive cantilever is used to quantitatively study the magnetic strength of the evolved microstructure in the diluted region as a function of the distance from the deposit/substrate interface, with the spatial resolution of about 100 nm. The acquired AFM/MFM images and the magnetic property profiles have been correlated with the variations in the chemical compositions in the diluted layers obtained by the energy dispersive spectroscopy (EDS). The study indicates that both the volume fraction of the ferromagnetic phase and its ferromagnetic strength decrease with increasing distance from the deposit/substrate interface. A distinct difference is observed in the ferromagnetic strength in the first few layers and the ferromagnetism is observed only near to the precipitates in the fifth layer. The study provides a better insight of the evolution of ferromagnetism in the diluted layers of Ni-Cr alloy deposits on stainless steel.

Chromosomal Copy Number Variation in Saccharomyces pastorianus Is Evidence for Extensive Genome Dynamics in Industrial Lager Brewing Strains

PubMed Central

van den Broek, M.; Bolat, I.; Nijkamp, J. F.; Ramos, E.; Luttik, M. A. H.; Koopman, F.; Geertman, J. M.; de Ridder, D.; Pronk, J. T.

2015-01-01

Lager brewing strains of Saccharomyces pastorianus are natural interspecific hybrids originating from the spontaneous hybridization of Saccharomyces cerevisiae and Saccharomyces eubayanus. Over the past 500 years, S. pastorianus has been domesticated to become one of the most important industrial microorganisms. Production of lager-type beers requires a set of essential phenotypes, including the ability to ferment maltose and maltotriose at low temperature, the production of flavors and aromas, and the ability to flocculate. Understanding of the molecular basis of complex brewing-related phenotypic traits is a prerequisite for rational strain improvement. While genome sequences have been reported, the variability and dynamics of S. pastorianus genomes have not been investigated in detail. Here, using deep sequencing and chromosome copy number analysis, we showed that S. pastorianus strain CBS1483 exhibited extensive aneuploidy. This was confirmed by quantitative PCR and by flow cytometry. As a direct consequence of this aneuploidy, a massive number of sequence variants was identified, leading to at least 1,800 additional protein variants in S. pastorianus CBS1483. Analysis of eight additional S. pastorianus strains revealed that the previously defined group I strains showed comparable karyotypes, while group II strains showed large interstrain karyotypic variability. Comparison of three strains with nearly identical genome sequences revealed substantial chromosome copy number variation, which may contribute to strain-specific phenotypic traits. The observed variability of lager yeast genomes demonstrates that systematic linking of genotype to phenotype requires a three-dimensional genome analysis encompassing physical chromosomal structures, the copy number of individual chromosomes or chromosomal regions, and the allelic variation of copies of individual genes. PMID:26150454

SYNCHROTRON RADIATION, FREE ELECTRON LASER, APPLICATION OF NUCLEAR TECHNOLOGY, ETC. Employing a Cerenkov detector for the thickness measurement of X-rays in a scattering background

NASA Astrophysics Data System (ADS)

Li, Shu-Wei; Kang, Ke-Jun; Wang, Yi; Li, Jin; Li, Yuan-Jing; Zhang, Qing-Jun

2010-12-01

The variation in environmental scattering background is a major source of systematic errors in X-ray inspection and measurement systems. As the energy of these photons consisting of environmental scattering background is much lower generally, the Cerenkov detectors having the detection threshold are likely insensitive to them and able to exclude their influence. A thickness measurement experiment is designed to verify the idea by employing a Cerenkov detector and an ionizing chamber for comparison. Furthermore, it is also found that the application of the Cerenkov detectors is helpful to exclude another systematic error from the variation of low energy components in the spectrum incident on the detector volume.

Estimation of population mean under systematic sampling

NASA Astrophysics Data System (ADS)

Noor-ul-amin, Muhammad; Javaid, Amjad

2017-11-01

In this study we propose a generalized ratio estimator under non-response for systematic random sampling. We also generate a class of estimators through special cases of generalized estimator using different combinations of coefficients of correlation, kurtosis and variation. The mean square errors and mathematical conditions are also derived to prove the efficiency of proposed estimators. Numerical illustration is included using three populations to support the results.

Comment on “Systematic variations of argon diffusion in feldspars and implications for thermochronometry” by Cassata and Renne

NASA Astrophysics Data System (ADS)

Lovera, Oscar M.; Harrison, T. Mark; Boehnke, Patrick

2015-02-01

Cassata and Renne (2013) is a data-rich paper potentially providing opportunities to systematically test long-standing models of argon diffusion behavior in feldspars and we congratulate them on a heroic achievement. That said, several of their interpretations are highly problematic due to misconceptions of both the nature of their sample and diffusion modeling.

Validation of the Thematic Mapper radiometric and geometric correction algorithms

NASA Technical Reports Server (NTRS)

Fischel, D.

1984-01-01

The radiometric and geometric correction algorithms for Thematic Mapper are critical to subsequent successful information extraction. Earlier Landsat scanners, known as Multispectral Scanners, produce imagery which exhibits striping due to mismatching of detector gains and biases. Thematic Mapper exhibits the same phenomenon at three levels: detector-to-detector, scan-to-scan, and multiscan striping. The cause of these variations has been traced to variations in the dark current of the detectors. An alternative formulation has been tested and shown to be very satisfactory. Unfortunately, the Thematic Mapper detectors exhibit saturation effects suffered while viewing extensive cloud areas, and is not easily correctable. The geometric correction algorithm has been shown to be remarkably reliable. Only minor and modest improvements are indicated and shown to be effective.

Spectroscopic observations of spatial and temporal variations on Venus

NASA Technical Reports Server (NTRS)

Young, A. T.; Young, L. G.; Woszczyk, A.

1974-01-01

Details of the Table Mountain spectroscopic patrol of Venus in September-October 1972 are given. The data indicate systematic variation over the disc, with more CO2 absorption near the terminator than at the limb, and slightly more in the southern than in the northern hemisphere. The semiregular four-day variation, reported to occur simultaneously over the disk at 8689 A by Young et al. (1973), is confirmed by observations of the 7820 A and 7883 A CO2 bands.

SDSS-IV MaNGA: Variation of the Stellar Initial Mass Function in Spiral and Early-type Galaxies

NASA Astrophysics Data System (ADS)

Li, Hongyu; Ge, Junqiang; Mao, Shude; Cappellari, Michele; Long, R. J.; Li, Ran; Emsellem, Eric; Dutton, Aaron A.; Li, Cheng; Bundy, Kevin; Thomas, Daniel; Drory, Niv; Lopes, Alexandre Roman

2017-04-01

We perform Jeans anisotropic modeling (JAM) on elliptical and spiral galaxies from the MaNGA DR13 sample. By comparing the stellar mass-to-light ratios estimated from stellar population synthesis and from JAM, we find a systematic variation of the initial mass function (IMF) similar to that in the earlier {{ATLAS}}3{{D}} results. Early-type galaxies (elliptical and lenticular) with lower velocity dispersions within one effective radius are consistent with a Chabrier-like IMF, while galaxies with higher velocity dispersions are consistent with a more bottom-heavy IMF such as the Salpeter IMF. Spiral galaxies have similar systematic IMF variations, but with slightly different slopes and larger scatters, due to the uncertainties caused by the higher gas fractions and extinctions for these galaxies. Furthermore, we examine the effects of stellar mass-to-light ratio gradients on our JAM modeling, and we find that the trends become stronger after considering the gradients.

Systematic ionospheric electron density tilts (SITs) at mid-latitudes and their associated HF bearing errors

NASA Astrophysics Data System (ADS)

Tedd, B. L.; Strangeways, H. J.; Jones, T. B.

1985-11-01

Systematic ionospheric tilts (SITs) at midlatitudes and the diurnal variation of bearing error for different transmission paths are examined. An explanation of diurnal variations of bearing error based on the dependence of ionospheric tilt on solar zenith angle and plasma transport processes is presented. The effect of vertical ion drift and the momentum transfer of neutral winds is investigated. During the daytime the transmissions are low and photochemical processes control SITs; however, at night transmissions are at higher heights and spatial and temporal variations of plasma transport processes influence SITs. A HF ray tracing technique which uses a three-dimensional ionospheric model based on predictions to simulate SIT-induced bearing errors is described; poor correlation with experimental data is observed and the causes for this are studied. A second model based on measured vertical-sounder data is proposed. Model two is applicable for predicting bearing error for a range of transmission paths and correlates well with experimental data.

Variations in Soft Soil of Troy False Color

NASA Image and Video Library

2009-06-25

The soft soil exposed when wheels of NASA Mars Exploration Rover Spirit dug into a patch of ground dubbed Troy exhibit variations in hue visible in this image, in which the colors have been stretched to emphasize the differences.

Effects of Sampling Strategy, Detection Probability, and Independence of Counts on the Use of Point Counts

Treesearch

Grey W. Pendleton

1995-01-01

Many factors affect the use of point counts for monitoring bird populations, including sampling strategies, variation in detection rates, and independence of sample points. The most commonly used sampling plans are stratified sampling, cluster sampling, and systematic sampling. Each of these might be most useful for different objectives or field situations. Variation...

Timescale of Petrogenetic Processes Recorded in the Mount Perkins Magma System, Northern Colorado River Extension Corridor, Arizona

NASA Technical Reports Server (NTRS)

Danielson, Lisa R.; Metcalf, Rodney V.; Miller, Calvin F.; Rhodes Gregory T.; Wooden, J. L.

2013-01-01

The Miocene Mt. Perkins Pluton is a small composite intrusive body emplaced in the shallow crust as four separate phases during the earliest stages of crustal extension. Phase 1 (oldest) consists of isotropic hornblende gabbro and a layered cumulate sequence. Phase 2 consists of quartz monzonite to quartz monzodiorite hosting mafic microgranitoid enclaves. Phase 3 is composed of quartz monzonite and is subdivided into mafic enclave-rich zones and enclave-free zones. Phase 4 consists of aphanitic dikes of mafic, intermediate and felsic compositions hosting mafic enclaves. Phases 2-4 enclaves record significant isotopic disequilibrium with surrounding granitoid host rocks, but collectively enclaves and host rocks form a cogenetic suite exhibiting systematic variations in Nd-Sr-Pb isotopes that correlate with major and trace elements. Phases 2-4 record multiple episodes of magma mingling among cogenetic hybrid magmas that formed via magma mixing and fractional crystallization at a deeper crustal. The mafic end-member was alkali basalt similar to nearby 6-4 Ma basalt with enriched OIB-like trace elements and Nd-Sr-Pb isotopes. The felsic end-member was a subalkaline crustal-derived magma. Phase 1 isotropic gabbro exhibits elemental and isotopic compositional variations at relatively constant SiO2, suggesting generation of isotropic gabbro by an open-system process involving two mafic end-members. One end-member is similar in composition to the OIB-like mafic end-member for phases 2-4; the second is similar to nearby 11-8 Ma tholeiite basalt exhibiting low epsilon (sub Nd), and depleted incompatible trace elements. Phase 1 cumulates record in situ fractional crystallization of an OIB-like mafic magma with isotopic evidence of crustal contamination by partial melts generated in adjacent Proterozoic gneiss. The Mt Perkins pluton records a complex history in a lithospheric scale magma system involving two distinct mantle-derived mafic magmas and felsic magma sourced in the crust. Mixing and fractional crystallization of these magmas at various levels in the crust generated a suite of intermediate composition magmas. U-Pb zircon SHRIMP ages of phase 1 (15.7 +/- 0.2 Ma), phase 3 (15.8 +/- 0.2 Ma) and phase 4 (15.4 +/- 0.3 Ma) document a 100-300k year timescale for petrogenetic processes recorded in the Mt Perkins magma system.

Firn Thickness Changes (1982-2015) Driven by SMB from MERRA-2, RACMO2.3, ERA-Int and AVHRR Surface Temperature and the Impacts to Greenland Ice Sheet Mass Balance

NASA Astrophysics Data System (ADS)

Li, J.; Medley, B.; Neumann, T.; Smith, B. E.; Luthcke, S. B.; Zwally, H. J.

2016-12-01

Surface mass balance (SMB) data are essential in the derivation of ice sheet mass balance. This is because ice sheet mass change consists of short-term and long-term variations. The short-term variations are directly given by the SMB data. For altimetry based ice sheet mass balance studies, these short-term mass changes are converted to firn thickness changes by using a firn densification-elevation model, and then the variations are subtracted from the altimetry measurements to give the long-term ice thickness changes that are associated with the density of ice. So far various SMB data sets such as ERA-Interim, RACMO and MERRA are available and some have been widely used in large number of ice sheet mass balance studies. However theses data sets exhibit the clear discrepancies in both random and systematic manner. In this study, we use our time dependent firn densification- elevation model, driven by the SMB data from MERRA-2, RACMO2.3 and ERA-Int for the period of 1982-2015 and the temperature variations from AVHRR for the same period to examine the corresponding firn thickness variations and the impacts to the mass changes over the Greenland ice sheet. The model was initialized with the1980's climate. Our results show that the relative smaller (centimeter level) differences in the firn thickness driven by the different data set occur at the early stage (1980's) of the model run. As the time progressing, the discrepancies between the SMB data sets accumulate, and the corresponding firn thickness differences quickly become larger with the value > 2m at the end of the period. Although the overall rates for the whole period driven by each of the three data sets are small ranging -0.2 - 0.2 cm a-1 (-3.0-2.7 Gt a-1), the decadal rates can vary greatly with magnitude > 3 cm a-1 and the impact to the Greenland mass change exceeds 30 Gt a-1.

Characterising the variations in ethnic skin colours: a new calibrated data base for human skin.

PubMed

Xiao, K; Yates, J M; Zardawi, F; Sueeprasan, S; Liao, N; Gill, L; Li, C; Wuerger, S

2017-02-01

Accurate skin colour measurements are important for numerous medical applications including the diagnosis and treatment of cutaneous disorders and the provision of maxillofacial soft tissue prostheses. In this study, we obtained accurate skin colour measurements from four different ethnic groups (Caucasian, Chinese, Kurdish, Thai) and at four different body locations (Forehead, cheek, inner arm, back of hand) with a view of establishing a new skin colour database for medical and cosmetic applications. Skin colours are measured using a spectrophotometer and converted to a device-independent standard colour appearance space (CIELAB) where skin colour is expressed as values along the three dimensions: Lightness L*, Redness a* and Yellowness b*. Skin colour differences and variation are then evaluated as a function of ethnicity and body location. We report three main results: (1) When plotted in a standard colour appearance space (CIELAB), skin colour distributions for the four ethnic groups overlap significantly, although there are systematic mean differences. Between ethnicities, the most significant skin colour differences occur along the yellowness dimension, with Thai skin exhibiting the highest yellowness (b*) value and Caucasian skin the lowest value. Facial redness (a*) is invariant across the four ethnic groups. (2) Between different body locations, there are significant variations in redness (a*), with the forehead showing the highest redness value and the inner arm the lowest. (3) The colour gamut is smallest in the Chinese sample and largest in the Caucasian sample, with the Chinese gamut lying entirely the Caucasian gamut. Similarly, the largest variability in skin tones is found in the Caucasian group, and the smallest in the Chinese group. Broadly speaking, skin colour variation can be explained by two main factors: individual differences in lightness and yellowness are mostly due to ethnicity, whereas differences in redness are primarily due to different body locations. Variations in lightness are more idiosyncratic probably reflecting the large influence of environmental factors such as exposure to sun. © 2016 The Authors. Skin Research and Technology Published by John Wiley & Sons Ltd.

Variability of cost-effectiveness estimates for pharmaceuticals in Western Europe: lessons for inferring generalizability.

PubMed

Barbieri, Marco; Drummond, Michael; Willke, Richard; Chancellor, Jeremy; Jolain, Bruno; Towse, Adrian

2005-01-01

It has long been suggested that, whereas the results of clinical studies of pharmaceuticals are generalizable from one jurisdiction to another, the results of economic evaluations are location dependent. There has been, however, little study of the causes of variation, whether differences in study results among countries are systematic, or whether they are important for decision making. A literature search was conducted to identify economic evaluations of pharmaceuticals conducted in two or more European countries. The studies identified were then classified by methodological type and analyzed to assess their level of variability and to identify the main causes of variation. Assessments were also made of the extent to which differences in study results among countries were systematic and whether they would lead to a different decision, assuming a range of values of the threshold willingness-to-pay for a life-year or quality-adjusted life-year (QALY). In total 46 intercountry drug comparisons were identified, 29 in multicountry studies and 17 in comparable single country studies that were considered to be sufficiently similar in terms of methodology. The type of study (i.e., trial-based or modeling study) had some impact on variability, but the most important factor was the extent of variation across countries in effectiveness, resource use or unit costs, allowed by the researcher's chosen methodology. There were few systematic differences in study results among countries, so a decision maker in country B, on seeing a recent economic evaluation of a new drug in country A, would have little basis on which to predict whether the drug, if evaluated, would be more or less cost-effective in his or her country. Given the extent of variation in cost-effectiveness estimates among countries, the importance of this for decision making depends on decision makers' thresholds in willingness-to-pay for a QALY or life-year. If a cost-effectiveness threshold (i.e., willingness-to-pay) for a life-year or QALY of dollar 50,000 were assumed, the same conclusion regarding cost-effectiveness would be reached in most cases. This review shows that cost-effectiveness results for pharmaceuticals vary from country to country in Western Europe and that these variations are not systematic. In addition, constraints imposed by analysts may reduce apparent variability in the estimates. The lessons for inferring generalizability are not straightforward, although the implications of variation for decision making depend critically on the cost-effectiveness thresholds applying in Western Europe.

Interstellar extinction curve variations towards the inner Milky Way: a challenge to observational cosmology

NASA Astrophysics Data System (ADS)

Nataf, David M.; Gonzalez, Oscar A.; Casagrande, Luca; Zasowski, Gail; Wegg, Christopher; Wolf, Christian; Kunder, Andrea; Alonso-Garcia, Javier; Minniti, Dante; Rejkuba, Marina; Saito, Roberto K.; Valenti, Elena; Zoccali, Manuela; Poleski, Radosław; Pietrzyński, Grzegorz; Skowron, Jan; Soszyński, Igor; Szymański, Michał K.; Udalski, Andrzej; Ulaczyk, Krzysztof; Wyrzykowski, Łukasz

2016-03-01

We investigate interstellar extinction curve variations towards ˜4 deg2 of the inner Milky Way in VIJKs photometry from the OGLE-III (third phase of the Optical Gravitational Lensing Experiment) and VVV (VISTA Variables in the Via Lactea) surveys, with supporting evidence from diffuse interstellar bands and F435W, F625W photometry. We obtain independent measurements towards ˜2000 sightlines of AI, E(V - I), E(I - J) and E(J - Ks), with median precision and accuracy of 2 per cent. We find that the variations in the extinction ratios AI/E(V - I), E(I - J)/E(V - I) and E(J - Ks)/E(V - I) are large (exceeding 20 per cent), significant and positively correlated, as expected. However, both the mean values and the trends in these extinction ratios are drastically shifted from the predictions of Cardelli and Fitzpatrick, regardless of how RV is varied. Furthermore, we demonstrate that variations in the shape of the extinction curve have at least two degrees of freedom, and not one (e.g. RV), which we confirm with a principal component analysis. We derive a median value of = 13.44, which is ˜60 per cent higher than the `standard' value. We show that the Wesenheit magnitude WI = I - 1.61(I - J) is relatively impervious to extinction curve variations. Given that these extinction curves are linchpins of observational cosmology, and that it is generally assumed that RV variations correctly capture variations in the extinction curve, we argue that systematic errors in the distance ladder from studies of Type Ia supernovae and Cepheids may have been underestimated. Moreover, the reddening maps from the Planck experiment are shown to systematically overestimate dust extinction by ˜100 per cent and lack sensitivity to extinction curve variations.

Race, common genetic variation, and therapeutic response disparities in heart failure.

PubMed

Taylor, Mathew R; Sun, Albert Y; Davis, Gordon; Fiuzat, Mona; Liggett, Stephen B; Bristow, Michael R

2014-12-01

Because of its comparatively recent evolution, Homo sapiens exhibit relatively little within-species genomic diversity. However, because of genome size, a proportionately small amount of variation creates ample opportunities for both rare mutations that may cause disease as well as more common genetic variations that may be important in disease modification or pharmacogenetics. Primarily because of the East African origin of modern humans, individuals of African ancestry (AA) exhibit greater degrees of genetic diversity than more recently established populations, such as those of European ancestry (EA) or Asian ancestry. Those population effects extend to differences in frequency of common gene variants that may be important in heart failure natural history or therapy. For cell-signaling mechanisms important in heart failure, we review and present new data for genetic variation between AA and EA populations. Data indicate that: 1) neurohormonal signaling mechanisms frequently (16 of the 19 investigated polymorphisms) exhibit racial differences in the allele frequencies of variants comprising key constituents; 2) some of these differences in allele frequency may differentially affect the natural history of heart failure in AA compared with EA individuals; and 3) in many cases, these differences likely play a role in observed racial differences in drug or device response. Copyright © 2014 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.

Diagnostic performance of major depression disorder case-finding instruments used among mothers of young children in the United States: A systematic review.

PubMed

Owora, Arthur H; Carabin, Hélène; Reese, Jessica; Garwe, Tabitha

2016-09-01

Growing recognition of the interrelated negative outcomes associated with major depression disorder (MDD) among mothers and their children has led to renewed public health interest in the early identification and treatment of maternal MDD. Healthcare providers, however, remain unsure of the validity of existing case-finding instruments. We conducted a systematic review to identify the most valid maternal MDD case-finding instrument used in the United States. We identified articles reporting the sensitivity and specificity of MDD case-finding instruments based on Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) by systematically searching through three electronic bibliographic databases, PubMed, PsycINFO, and EMBASE, from 1994 to 2014. Study eligibility and quality were evaluated using the Standards for the Reporting of Diagnostic Accuracy studies and Quality Assessment of Diagnostic Accuracy Studies guidelines respectively. Overall, we retrieved 996 unduplicated articles and selected 74 for full-text review. Of these, 14 articles examining 21 different instruments were included in the systematic review. The 10 item Edinburgh Postnatal Depression Scale and Postpartum Depression Screening Scale had the most stable (lowest variation) and highest diagnostic performance during the antepartum and postpartum periods (sensitivity range: 0.63-0.94 and 0.67-0.95; specificity range: 0.83-0.98 and 0.68-0.97 respectively). Greater variation in diagnostic performance was observed among studies with higher MDD prevalence. Factors that explain greater variation in instrument diagnostic performance in study populations with higher MDD prevalence were not examined. Findings suggest that the diagnostic performance of maternal MDD case-finding instruments is peripartum period-specific. Published by Elsevier B.V.

Systematic error of the Gaia DR1 TGAS parallaxes from data for the red giant clump

NASA Astrophysics Data System (ADS)

Gontcharov, G. A.

2017-08-01

Based on the Gaia DR1 TGAS parallaxes and photometry from the Tycho-2, Gaia, 2MASS, andWISE catalogues, we have produced a sample of 100 000 clump red giants within 800 pc of the Sun. The systematic variations of the mode of their absolute magnitude as a function of the distance, magnitude, and other parameters have been analyzed. We show that these variations reach 0.7 mag and cannot be explained by variations in the interstellar extinction or intrinsic properties of stars and by selection. The only explanation seems to be a systematic error of the Gaia DR1 TGAS parallax dependent on the square of the observed distance in kpc: 0.18 R 2 mas. Allowance for this error reduces significantly the systematic dependences of the absolute magnitude mode on all parameters. This error reaches 0.1 mas within 800 pc of the Sun and allows an upper limit for the accuracy of the TGAS parallaxes to be estimated as 0.2 mas. A careful allowance for such errors is needed to use clump red giants as "standard candles." This eliminates all discrepancies between the theoretical and empirical estimates of the characteristics of these stars and allows us to obtain the first estimates of the modes of their absolute magnitudes from the Gaia parallaxes: mode( M H ) = -1.49 m ± 0.04 m , mode( M Ks ) = -1.63 m ± 0.03 m , mode( M W1) = -1.67 m ± 0.05 m mode( M W2) = -1.67 m ± 0.05 m , mode( M W3) = -1.66 m ± 0.02 m , mode( M W4) = -1.73 m ± 0.03 m , as well as the corresponding estimates of their de-reddened colors.

Taxonomy of Individual Variations in Aesthetic Responses to Fractal Patterns

PubMed Central

Spehar, Branka; Walker, Nicholas; Taylor, Richard P.

2016-01-01

In two experiments, we investigate group and individual preferences in a range of different types of patterns with varying fractal-like scaling characteristics. In Experiment 1, we used 1/f filtered grayscale images as well as their thresholded (black and white) and edges only counterparts. Separate groups of observers viewed different types of images varying in slope of their amplitude spectra. Although with each image type, the groups exhibited the “universal” pattern of preference for intermediate amplitude spectrum slopes, we identified 4 distinct sub-groups in each case. Sub-group 1 exhibited a typical peak preference for intermediate amplitude spectrum slopes (“intermediate”; approx. 50%); sub-group 2 exhibited a linear increase in preference with increasing amplitude spectrum slope (“smooth”; approx. 20%), while sub-group 3 exhibited a linear decrease in preference as a function of the amplitude spectrum slope (“sharp”; approx. 20%). Sub-group 4 revealed no significant preference (“other”; approx. 10%). In Experiment 2, we extended the range of different image types and investigated preferences within the same observers. We replicate the results of our first experiment and show that individual participants exhibit stable patterns of preference across a wide range of image types. In both experiments, Q-mode factor analysis identified two principal factors that were able to explain more than 80% of interindividual variations in preference across all types of images, suggesting a highly similar dimensional structure of interindividual variations in preference for fractal-like scaling characteristics. PMID:27458365

Comparison of Three E-Beam Techniques for Electric Field Imaging and Carrier Diffusion Length Measurement on the Same Nanowires.

PubMed

Donatini, F; de Luna Bugallo, Andres; Tchoulfian, Pierre; Chicot, Gauthier; Sartel, Corinne; Sallet, Vincent; Pernot, Julien

2016-05-11

Whereas nanowire (NW)-based devices offer numerous advantages compared to bulk ones, their performances are frequently limited by an incomplete understanding of their properties where surface effect should be carefully considered. Here, we demonstrate the ability to spatially map the electric field and determine the exciton diffusion length in NW by using an electron beam as the single excitation source. This approach is performed on numerous single ZnO NW Schottky diodes whose NW radius vary from 42.5 to 175 nm. The dominant impact of the surface on the NW properties is revealed through the comparison of three different physical quantities recorded on the same NW: electron-beam induced current, cathodoluminescence, and secondary electron signal. Indeed, the space charge region near the Schottky contact exhibits an unusual linear variation with reverse bias whatever the NW radius. On the contrary, the exciton diffusion length is shown to be controlled by the NW radius through surface recombination. This systematic comparison performed on a single ZnO NW demonstrates the power of these complementary techniques in understanding NW properties.

Influence of thermal treatment temperature on high-performance varistors prepared by hot-dipping tin oxide thin films in Nb2O5 powder

NASA Astrophysics Data System (ADS)

Wang, Qi; Peng, Zhijian; Wang, Yang; Fu, Xiuli

2018-06-01

SnOx-Nb2O5 thin film varistors were prepared by hot-dipping oxygen-deficient tin oxide films in Nb2O5 powder in air, and the influence of hot-dipping temperature (HDT) on the varistor performance of the samples was systematically explored. When the HDT increased from 300 to 700 °C, the nonlinear coefficient of the samples raised first and then dropped down, reaching the maximum of 14.73 at 500 °C, and the breakdown electric field exhibited a similar variation trend, gaining the peak value of 0.0201 V/nm at this temperature. Correspondingly, the leakage current decreased first and then increased with increasing HDT, reaching the minimum of 17.1 mA/cm2 at 500 °C. Besides, it was proposed that a grain-boundary defect barrier model was responsible for the nonlinear behavior of the obtained SnOx-Nb2O5 film varistors. This high-performance thin film varistor with nanoscaled thickness might be much promising in nano-devices or devices working in low voltage.

On the mass of the compact object in the black hole binary A0620-00

NASA Technical Reports Server (NTRS)

Haswell, Carole A.; Robinson, Edward L.; Horne, Keith; Stiening, Rae F.; Abbott, Timothy M. C.

1993-01-01

Multicolor orbital light curves of the black hole candidate binary A0620-00 are presented. The light curves exhibit ellipsoidal variations and a grazing eclipse of the mass donor companion star by the accretion disk. Synthetic light curves were generated using realistic mass donor star fluxes and an isothermal blackbody disk. For mass ratios of q = M sub 1/M sub 2 = 5.0, 10.6, and 15.0 systematic searches were executed in parameter space for synthetic light curves that fit the observations. For each mass ratio, acceptable fits were found only for a small range of orbital inclinations. It is argued that the mass ratio is unlikely to exceed q = 10.6, and an upper limit of 0.8 solar masses is placed on the mass of the companion star. These constraints imply 4.16 +/- 0.1 to 5.55 +/- 0.15 solar masses. The lower limit on M sub 1 is more than 4-sigma above the mass of a maximally rotating neutron star, and constitutes further strong evidence in favor of a black hole primary in this system.

Scrutinizing MHC-I binding peptides and their limits of variation.

PubMed

Koch, Christian P; Perna, Anna M; Pillong, Max; Todoroff, Nickolay K; Wrede, Paul; Folkers, Gerd; Hiss, Jan A; Schneider, Gisbert

2013-01-01

Designed peptides that bind to major histocompatibility protein I (MHC-I) allomorphs bear the promise of representing epitopes that stimulate a desired immune response. A rigorous bioinformatical exploration of sequence patterns hidden in peptides that bind to the mouse MHC-I allomorph H-2K(b) is presented. We exemplify and validate these motif findings by systematically dissecting the epitope SIINFEKL and analyzing the resulting fragments for their binding potential to H-2K(b) in a thermal denaturation assay. The results demonstrate that only fragments exclusively retaining the carboxy- or amino-terminus of the reference peptide exhibit significant binding potential, with the N-terminal pentapeptide SIINF as shortest ligand. This study demonstrates that sophisticated machine-learning algorithms excel at extracting fine-grained patterns from peptide sequence data and predicting MHC-I binding peptides, thereby considerably extending existing linear prediction models and providing a fresh view on the computer-based molecular design of future synthetic vaccines. The server for prediction is available at http://modlab-cadd.ethz.ch (SLiDER tool, MHC-I version 2012).

Spectral variation during one quasi-periodic oscillation cycle in the black hole candidate H1743-322

NASA Astrophysics Data System (ADS)

Sarathi Pal, Partha; Debnath, Dipak; Chakrabarti, Sandip Kumar

2016-07-01

From the nature of energy dependence of the power density spectra, it is believed that the oscillation of the Compton cloud may be related to low frequency quasi-periodic oscillations (LFQPOs). In the context of two component advective flow (TCAF) solution, the centrifugal pressure supported boundary layer of a transonic flow acts as the Compton cloud. This region undergoes resonance oscillation when cooling time scale roughly agrees with infall time scale as matter crosses this region. By carefully separating photons emitted at different phases of a complete oscillation, we establish beyond reasonable doubt that such an oscillation is the cause of LFQPOs. We show that the degree of Comptonization and therefore the spectral properties of the flow oscillate systematically with the phase of LFQPOs. We analysis the properties of a 0.2Hz LFQPO exhibited by a black hole candidate H 1743-322 using the 3-80 keV data from NuSTAR satellite. This object was chosen because of availability of high quality data for a relatively low frequency oscillation, rendering easy phase-wise of separation of the light curve data.

A comprehensive evaluation of input data-induced uncertainty in nonpoint source pollution modeling

NASA Astrophysics Data System (ADS)

Chen, L.; Gong, Y.; Shen, Z.

2015-11-01

Watershed models have been used extensively for quantifying nonpoint source (NPS) pollution, but few studies have been conducted on the error-transitivity from different input data sets to NPS modeling. In this paper, the effects of four input data, including rainfall, digital elevation models (DEMs), land use maps, and the amount of fertilizer, on NPS simulation were quantified and compared. A systematic input-induced uncertainty was investigated using watershed model for phosphorus load prediction. Based on the results, the rain gauge density resulted in the largest model uncertainty, followed by DEMs, whereas land use and fertilizer amount exhibited limited impacts. The mean coefficient of variation for errors in single rain gauges-, multiple gauges-, ASTER GDEM-, NFGIS DEM-, land use-, and fertilizer amount information was 0.390, 0.274, 0.186, 0.073, 0.033 and 0.005, respectively. The use of specific input information, such as key gauges, is also highlighted to achieve the required model accuracy. In this sense, these results provide valuable information to other model-based studies for the control of prediction uncertainty.

New Insights on co-seismic landslide clustering

NASA Astrophysics Data System (ADS)

Meunier, Patrick; Marc, Odin; Hovius, Niels

2015-04-01

Earthquake-triggered landslides tend to cluster along topographic crests while rainfall-induced landslides should occur downslope preferentially, where pore pressure induced by groundwater flows is the highest [1]. Past studies on landslide clustering are all based on the analysis of complete dataset or subdataset of landslides associated with a given event (seismic or climatic) as a whole. In this work, we document the spatial and temporal variations of the landslide position (on hillslopes) within the epicentral area of the 1994 Northridge, the 1999 Chichi, the 2004 Niigata, the 2008 Iwate and the 2008 Wenchuan earthquakes. We show that crest clustering is not systematic, non uniform in space and exhibit patterns that vary a lot from one case to another. These patterns are not easy to interpret as they don't seem to be controlled by a single governing parameter but result from a complex interaction between local (hillslope length and gradient, lithology) and seismic (distance to source, slope aspect, radiation pattern, coseismic uplift) parameters. [1] Meunier, P., Hovius, N., & Haines, J. A. (2008). Topographic site effects and the location of earthquake induced landslides. Earth and Planetary Science Letters, 275(3), 221-232

Migration and Extension of Solar Active Longitudinal Zones

NASA Astrophysics Data System (ADS)

Gyenge, N.; Baranyi, T.; Ludmány, A.

2014-02-01

Solar active longitudes show a characteristic migration pattern in the Carrington coordinate system if they can be identified at all. By following this migration, the longitudinal activity distribution around the center of the band can be determined. The half-width of the distribution is found to be varying in Cycles 21 - 23, and in some time intervals it was as narrow as 20 - 30 degrees. It was more extended around a maximum but it was also narrow when the activity jumped to the opposite longitude. Flux emergence exhibited a quasi-periodic variation within the active zone with a period of about 1.3 years. The path of the active-longitude migration does not support the view that it might be associated with the 11-year solar cycle. These results were obtained for a limited time interval of a few solar cycles and, bearing in mind uncertainties of the migration-path definition, are only indicative. For the major fraction of the dataset no systematic active longitudes were found. Sporadic migration of active longitudes was identified only for Cycles 21 - 22 in the northern hemisphere and Cycle 23 in the southern hemisphere.

A Photometric Survey of the Open Clusters NGC 7789 and M67

NASA Astrophysics Data System (ADS)

Janes, Kenneth

2010-01-01

Although there is strong evidence that stellar activity declines as a star ages, beyond about the age of the Hyades (600 Myr) there is little direct confirmation of this decline in stars of known age. This report is an update of an earlier report (Hayes-Gehrke, et al., 2004, AJ, 128, 2862) of a long-term project to explore stellar activity in old open clusters. I have now accumulated 12 years of photometry of the old clusters NGC 7789 (about 1.8 Gyr) and M 67 (about 4 Gyr). An analysis of these data has revealed a substantial number of low-amplitude variable stars in both clusters, including a number of previously-discovered eclipsing binary stars, and several stars near the main sequence turnoff of both clusters that exhibit apparently erratic variations. Some of the M 67 erratics are known X-ray sources. On the main sequence, the large majority of stars show little or no evidence for variability at the 0.1% - 0.2% level, consistent with a regular systematic decline in activity level with age.

Influence of memory effect on the state-of-charge estimation of large-format Li-ion batteries based on LiFePO4 cathode

NASA Astrophysics Data System (ADS)

Shi, Wei; Wang, Jiulin; Zheng, Jianming; Jiang, Jiuchun; Viswanathan, Vilayanur; Zhang, Ji-Guang

2016-04-01

In this work, we systematically investigated the influence of the memory effect of LiFePO4 cathodes in large-format full batteries. The electrochemical performance of the electrodes used in these batteries was also investigated separately in half-cells to reveal their intrinsic properties. We noticed that the memory effect of LiFePO4/graphite cells depends not only on the maximum state of charge reached during the memory writing process, but is also affected by the depth of discharge reached during the memory writing process. In addition, the voltage deviation in a LiFePO4/graphite full battery is more complex than in a LiFePO4/Li half-cell, especially for a large-format battery, which exhibits a significant current variation in the region near its terminals. Therefore, the memory effect should be taken into account in advanced battery management systems to further extend the long-term cycling stabilities of Li-ion batteries using LiFePO4 cathodes.

Electroreduction of Er 3+ in nonaqueous solvents

DOE PAGES

Small, Leo J.; Sears, Jeremiah M.; Lambert, Timothy N.; ...

2016-09-15

Here, the electroreduction of Er 3+ in propylene carbonate, N,N-dimethylformamide, or a variety of quaternary ammonium ionic liquids (ILs) was investigated using [Er(OTf) 3] and [Er(NTf 2) 3]. Systematic variation of the ILs' cation and anion, Er 3+ salt, and electrode material revealed a disparity in electrochemical interactions not previously seen. For most ILs at a platinum electrode, cyclic voltammetry exhibits irreversible interactions between Er 3+ salts and the electrode at potentials significantly less than the theoretical reduction potential for Er 3+. Throughout all solvent–salt systems tested, a deposit could be formed on the electrode, though obtaining a high purity,more » crystalline Er 0 deposit is challenging due to the extreme reactivity of the deposit and resulting chemical interactions, often resulting in the formation of a complex, amorphous solid–electrolyte interface that slowed deposition rates. Comparison of platinum, gold, nickel, and glassy carbon (GC) working electrodes revealed oxidation processes unique to the platinum surface. While no appreciable reduction current was observed on GC at the potentials investigated, deposits were seen on platinum, gold, and nickel electrodes.« less

Inter-satellite calibration of FengYun 3 medium energy electron fluxes with POES electron measurements

NASA Astrophysics Data System (ADS)

Zhang, Yang; Ni, Binbin; Xiang, Zheng; Zhang, Xianguo; Zhang, Xiaoxin; Gu, Xudong; Fu, Song; Cao, Xing; Zou, Zhengyang

2018-05-01

We perform an L-shell dependent inter-satellite calibration of FengYun 3 medium energy electron measurements with POES measurements based on rough orbital conjunctions within 5 min × 0.1 L × 0.5 MLT. By comparing electron flux data between the U.S. Polar Orbiting Environmental Satellites (POES) and Chinese sun-synchronous satellites including FY-3B and FY-3C for a whole year of 2014, we attempt to remove less reliable data and evaluate systematic uncertainties associated with the FY-3B and FY-3C datasets, expecting to quantify the inter-satellite calibration factors for the 150-350 keV energy channel at L = 2-7. Compared to the POES data, the FY-3B and FY-3C data generally exhibit a similar trend of electron flux variations but more or less underestimate them within a factor of 5 for the medium electron energy 150-350 keV channel. Good consistency in the flux conjunctions after the inter-calibration procedures gives us certain confidence to generalize our method to calibrate electron flux measurements from various satellite instruments.

Characterization of Equine Infectious Anemia Virus Long Terminal Repeat Quasispecies In Vitro and In Vivo

PubMed Central

Wang, Xue-Feng; Liu, Qiang; Wang, Yu-Hong; Wang, Shuai; Chen, Jie; Lin, Yue-Zhi; Ma, Jian; Zhou, Jian-Hua

2018-01-01

ABSTRACT The equine infectious anemia virus (EIAV) attenuated vaccine was developed by long-term passaging of a field-isolated virulent strain in cross-species hosts, followed by successive cultivation in cells in vitro. To explore the molecular mechanism underlying the evolution of the EIAV attenuated vaccine, a systematic study focusing on long-terminal-repeat (LTR) variation in numerous virus strains ranging from virulent EIAV to attenuated EIAV was performed over time both in vitro and in vivo. Two hypervariable regions were identified within the U3 region in the enhancer region (EHR) and the negative regulatory element (NRE) and within the R region in the transcription start site (TSS) and the Tat-activating region (TAR). Among these sites, variation in the U3 region resulted in the formation of additional transcription factor binding sites; this variation of the in vitro-adapted strains was consistent with the loss of pathogenicity. Notably, the same LTR variation pattern was observed both in vitro and in vivo. Generally, the LTR variation in both the attenuated virus and the virulent strain fluctuated over time in vivo. Interestingly, the attenuated-virus-specific LTR variation was also detected in horses infected with the virulent strain, supporting the hypothesis that the evolution of an attenuated virus might have involved branching from EIAV quasispecies. This hypothesis was verified by phylogenetic analysis. The present systematic study examining the molecular evolution of attenuated EIAV from EIAV quasispecies may provide an informative model reflecting the evolution of similar lentiviruses. IMPORTANCE The attenuated EIAV vaccine was the first lentiviral vaccine used to successfully control for equine infectious anemia in China. This vaccine provides an important reference for studying the relationship between EIAV gene variation and changes in biological characteristics. Importantly, the vaccine provides a model for the investigation of lentiviral quasispecies evolution. This study followed the “natural” development of the attenuated EIAV vaccine by use of a systematic analysis of LTR evolution in vitro and in vivo. The results revealed that the increase in LTR variation with passaging was accompanied by a decrease in virulence, which indicated that LTR variability might parallel the attenuation of virulence. Interestingly, the attenuated-virus-specific LTR variation was also detected in virulent-strain-infected horses, a finding consistent with those of previous investigations of gp90 and S2 evolution. Therefore, we present a hypothesis that the evolution of the attenuated virus may involve branching from EIAV quasispecies present in vivo. PMID:29386282

European Community Respiratory Health Survey calibration project of dosimeter driving pressures.

PubMed

Ward, R J; Ward, C; Johns, D P; Skoric, B; Abramson, M; Walters, E H

2002-02-01

Two potential sources of systematic variation in output from Mefar dosimeters, the system used in the European Community Respiratory Health Survey (ECRHS) study have been evaluated: individual nebulizer characteristics and dosimeter driving pressure. Output variation from 366 new nebulizers produced in two batches for the second ECRHS were evaluated, using a solute tracer method, at a fixed driving pressure. The relationship between dosimeter driving pressure was then characterized and between-centre variation in dosimeter driving pressure was evaluated in an Internet-based survey. A systematic difference between nebulizers manufactured in the two batches was identified. Batch one had a mean+/-SD output of 7.0+/-0.8 mg x s(-1) and batch two, 6.3+/-0.7 mg x s(-1) (p<0.005). There was a wide range of driving pressures generated by Mefar dosimeters as set, ranging between 70-245 kPa, with most outside the quoted manufacturer's specification of 180+/-5%. Nebulizer output was confirmed as linearly related to dosimeter driving pressure (coefficient of determination (R2)=0.99, output=0.0377 x driving pressure-0.4151). The range in driving pressures observed was estimated as consistent with a variation of about one doubling in the provocative dose causing a 20% fall in forced expiratory volume in one second. Systematic variation has been identified that constitutes potentially significant confounders for between-centre comparisons of airway responsiveness in the European Community Respiratory Health Survey, with the dosimeter driving pressure representing the most serious issue. This work confirms the need for appropriate quality control of both nebulizer output and dosimeter driving pressure, in laboratories undertaking field measurements of airway responsiveness. In particular, appropriate data on driving pressures need to be collected and factored into between-centre comparisons. Comprehensive collection of such data to optimize quality control is practicable and has been instigated by the organizing committee for the European Community Respiratory Health Survey II.

Population genomics reveals a candidate gene involved in bumble bee pigmentation.

PubMed

Pimsler, Meaghan L; Jackson, Jason M; Lozier, Jeffrey D

2017-05-01

Variation in bumble bee color patterns is well-documented within and between species. Identifying the genetic mechanisms underlying such variation may be useful in revealing evolutionary forces shaping rapid phenotypic diversification. The widespread North American species Bombus bifarius exhibits regional variation in abdominal color forms, ranging from red-banded to black-banded phenotypes and including geographically and phenotypically intermediate forms. Identifying genomic regions linked to this variation has been complicated by strong, near species level, genome-wide differentiation between red- and black-banded forms. Here, we instead focus on the closely related black-banded and intermediate forms that both belong to the subspecies B. bifarius nearcticus . We analyze an RNA sequencing (RNAseq) data set and identify a cluster of single nucleotide polymorphisms (SNPs) within one gene, Xanthine dehydrogenase/oxidase -like, that exhibit highly unusual differentiation compared to the rest of the sequenced genome. Homologs of this gene contribute to pigmentation in other insects, and results thus represent a strong candidate for investigating the genetic basis of pigment variation in B. bifarius and other bumble bee mimicry complexes.

Iron Redox Systematics of Shergottites and Martian Magmas

NASA Technical Reports Server (NTRS)

Righter, Kevin; Danielson, L. R.; Martin, A. M.; Newville, M.; Choi, Y.

2010-01-01

Martian meteorites record a range of oxygen fugacities from near the IW buffer to above FMQ buffer [1]. In terrestrial magmas, Fe(3+)/ SigmaFe for this fO2 range are between 0 and 0.25 [2]. Such variation will affect the stability of oxides, pyroxenes, and how the melt equilibrates with volatile species. An understanding of the variation of Fe(3+)/SigmaFe for martian magmas is lacking, and previous work has been on FeO-poor and Al2O3-rich terrestrial basalts. We have initiated a study of the iron redox systematics of martian magmas to better understand FeO and Fe2O3 stability, the stability of magnetite, and the low Ca/high Ca pyroxene [3] ratios observed at the surface.

Trust and terrorism: citizen responses to anti-terrorism performance history.

PubMed

Johnson, Branden B

2010-09-01

The "intuitive detection theorists" model of trust posits greater trust for correctly distinguishing danger from safety and an activist response under uncertainty about danger. An American sample evaluated U.S. Department of Homeland Security (DHS) performance after two possible terrorism events in which DHS has the same activist or nonactivist response bias. Outcomes were two successes (bombing prevented or lack of threat accurately foretold), two failures (bombing or DHS action against high school prank leads to student deaths), or a mix. Hindsight empathy (a belief one would have made the same decision) differed across treatments but trust less so; contrary to a similar one-event experiment in Germany, an active but incorrect response did not raise trust relative to passive incorrect action. Political conservatives were much more trusting and empathetic than liberals, and all ideological groups (including moderates) exhibited little internal variation reflecting experimental conditions. Consistently accurate outcomes rated significantly higher in empathy than either inconsistent results or consistent inaccuracy (the lowest rated); trust exhibited no significant differences. Results in this study show actual (experimentally manipulated) performance being trumped by the interpretive screen of political ideology, but this seemed less the case in the earlier German study, despite its finding of a strong moderating effect of right-wing authoritarianism. Trust scholars need to attend more to effects of performance history (i.e., a sequence of events) and their limiting factors. More systematic testing of effects of ideology and performance history would enhance future research on trust. © 2010 Society for Risk Analysis.

A harmonic analysis approach to joint inversion of P-receiver functions and wave dispersion data in high dense seismic profiles

NASA Astrophysics Data System (ADS)

Molina-Aguilera, A.; Mancilla, F. D. L.; Julià, J.; Morales, J.

2017-12-01

Joint inversion techniques of P-receiver functions and wave dispersion data implicitly assume an isotropic radial stratified earth. The conventional approach invert stacked radial component receiver functions from different back-azimuths to obtain a laterally homogeneous single-velocity model. However, in the presence of strong lateral heterogeneities as anisotropic layers and/or dipping interfaces, receiver functions are considerably perturbed and both the radial and transverse components exhibit back azimuthal dependences. Harmonic analysis methods exploit these azimuthal periodicities to separate the effects due to the isotropic flat-layered structure from those effects caused by lateral heterogeneities. We implement a harmonic analysis method based on radial and transverse receiver functions components and carry out a synthetic study to illuminate the capabilities of the method in isolating the isotropic flat-layered part of receiver functions and constrain the geometry and strength of lateral heterogeneities. The independent of the baz P receiver function are jointly inverted with phase and group dispersion curves using a linearized inversion procedure. We apply this approach to high dense seismic profiles ( 2 km inter-station distance, see figure) located in the central Betics (western Mediterranean region), a region which has experienced complex geodynamic processes and exhibit strong variations in Moho topography. The technique presented here is robust and can be applied systematically to construct a 3-D model of the crust and uppermost mantle across large networks.

Spreading rate dependence of gravity anomalies along oceanic transform faults.

PubMed

Gregg, Patricia M; Lin, Jian; Behn, Mark D; Montési, Laurent G J

2007-07-12

Mid-ocean ridge morphology and crustal accretion are known to depend on the spreading rate of the ridge. Slow-spreading mid-ocean-ridge segments exhibit significant crustal thinning towards transform and non-transform offsets, which is thought to arise from a three-dimensional process of buoyant mantle upwelling and melt migration focused beneath the centres of ridge segments. In contrast, fast-spreading mid-ocean ridges are characterized by smaller, segment-scale variations in crustal thickness, which reflect more uniform mantle upwelling beneath the ridge axis. Here we present a systematic study of the residual mantle Bouguer gravity anomaly of 19 oceanic transform faults that reveals a strong correlation between gravity signature and spreading rate. Previous studies have shown that slow-slipping transform faults are marked by more positive gravity anomalies than their adjacent ridge segments, but our analysis reveals that intermediate and fast-slipping transform faults exhibit more negative gravity anomalies than their adjacent ridge segments. This finding indicates that there is a mass deficit at intermediate- and fast-slipping transform faults, which could reflect increased rock porosity, serpentinization of mantle peridotite, and/or crustal thickening. The most negative anomalies correspond to topographic highs flanking the transform faults, rather than to transform troughs (where deformation is probably focused and porosity and alteration are expected to be greatest), indicating that crustal thickening could be an important contributor to the negative gravity anomalies observed. This finding in turn suggests that three-dimensional magma accretion may occur near intermediate- and fast-slipping transform faults.

Time Course of Visual Extrapolation Accuracy

DTIC Science & Technology

1995-09-01

The pond and duckweed problem: Three experiments on the misperception of exponential growth . Acta Psychologica 43, 239-251. Wiener, E.L., 1962...random variation in tracker velocity. Both models predicted changes in hit and false alarm rates well, except in a condition where response asymmetries...systematic velocity error in tracking, only random variation in tracker velocity. Both models predicted changes in hit and false alarm rates well

CDO budgeting

NASA Astrophysics Data System (ADS)

Nesladek, Pavel; Wiswesser, Andreas; Sass, Björn; Mauermann, Sebastian

2008-04-01

The Critical dimension off-target (CDO) is a key parameter for mask house customer, affecting directly the performance of the mask. The CDO is the difference between the feature size target and the measured feature size. The change of CD during the process is either compensated within the process or by data correction. These compensation methods are commonly called process bias and data bias, respectively. The difference between data bias and process bias in manufacturing results in systematic CDO error, however, this systematic error does not take into account the instability of the process bias. This instability is a result of minor variations - instabilities of manufacturing processes and changes in materials and/or logistics. Using several masks the CDO of the manufacturing line can be estimated. For systematic investigation of the unit process contribution to CDO and analysis of the factors influencing the CDO contributors, a solid understanding of each unit process and huge number of masks is necessary. Rough identification of contributing processes and splitting of the final CDO variation between processes can be done with approx. 50 masks with identical design, material and process. Such amount of data allows us to identify the main contributors and estimate the effect of them by means of Analysis of variance (ANOVA) combined with multivariate analysis. The analysis does not provide information about the root cause of the variation within the particular unit process, however, it provides a good estimate of the impact of the process on the stability of the manufacturing line. Additionally this analysis can be used to identify possible interaction between processes, which cannot be investigated if only single processes are considered. Goal of this work is to evaluate limits for CDO budgeting models given by the precision and the number of measurements as well as partitioning the variation within the manufacturing process. The CDO variation splits according to the suggested model into contributions from particular processes or process groups. Last but not least the power of this method to determine the absolute strength of each parameter will be demonstrated. Identification of the root cause of this variation within the unit process itself is not scope of this work.

Cross-Cultural Patterns in Dynamic Ratings of Positive and Negative Natural Emotional Behaviour

PubMed Central

Sneddon, Ian; McKeown, Gary; McRorie, Margaret; Vukicevic, Tijana

2011-01-01

Background Studies of cross-cultural variations in the perception of emotion have typically compared rates of recognition of static posed stimulus photographs. That research has provided evidence for universality in the recognition of a range of emotions but also for some systematic cross-cultural variation in the interpretation of emotional expression. However, questions remain about how widely such findings can be generalised to real life emotional situations. The present study provides the first evidence that the previously reported interplay between universal and cultural influences extends to ratings of natural, dynamic emotional stimuli. Methodology/Principal Findings Participants from Northern Ireland, Serbia, Guatemala and Peru used a computer based tool to continuously rate the strength of positive and negative emotion being displayed in twelve short video sequences by people from the United Kingdom engaged in emotional conversations. Generalized additive mixed models were developed to assess the differences in perception of emotion between countries and sexes. Our results indicate that the temporal pattern of ratings is similar across cultures for a range of emotions and social contexts. However, there are systematic differences in intensity ratings between the countries, with participants from Northern Ireland making the most extreme ratings in the majority of the clips. Conclusions/Significance The results indicate that there is strong agreement across cultures in the valence and patterns of ratings of natural emotional situations but that participants from different cultures show systematic variation in the intensity with which they rate emotion. Results are discussed in terms of both ‘in-group advantage’ and ‘display rules’ approaches. This study indicates that examples of natural spontaneous emotional behaviour can be used to study cross-cultural variations in the perception of emotion. PMID:21364739

Cross-cultural patterns in dynamic ratings of positive and negative natural emotional behaviour.

PubMed

Sneddon, Ian; McKeown, Gary; McRorie, Margaret; Vukicevic, Tijana

2011-02-18

Studies of cross-cultural variations in the perception of emotion have typically compared rates of recognition of static posed stimulus photographs. That research has provided evidence for universality in the recognition of a range of emotions but also for some systematic cross-cultural variation in the interpretation of emotional expression. However, questions remain about how widely such findings can be generalised to real life emotional situations. The present study provides the first evidence that the previously reported interplay between universal and cultural influences extends to ratings of natural, dynamic emotional stimuli. Participants from Northern Ireland, Serbia, Guatemala and Peru used a computer based tool to continuously rate the strength of positive and negative emotion being displayed in twelve short video sequences by people from the United Kingdom engaged in emotional conversations. Generalized additive mixed models were developed to assess the differences in perception of emotion between countries and sexes. Our results indicate that the temporal pattern of ratings is similar across cultures for a range of emotions and social contexts. However, there are systematic differences in intensity ratings between the countries, with participants from Northern Ireland making the most extreme ratings in the majority of the clips. The results indicate that there is strong agreement across cultures in the valence and patterns of ratings of natural emotional situations but that participants from different cultures show systematic variation in the intensity with which they rate emotion. Results are discussed in terms of both 'in-group advantage' and 'display rules' approaches. This study indicates that examples of natural spontaneous emotional behaviour can be used to study cross-cultural variations in the perception of emotion.

A New Catalog of Variable Stars in the Field of the Open Cluster M37

NASA Astrophysics Data System (ADS)

Chang, S.-W.; Byun, Y.-I.; Hartman, J. D.

2015-07-01

We present a comprehensive re-analysis of stellar photometric variability in the field of the open cluster M37 following the application of a new photometry and de-trending method to the MMT/Megacam image archive. This new analysis allows a rare opportunity to explore photometric variability over a broad range of timescales, from minutes to a month. The intent of this work is to examine the entire sample of more than 30,000 objects for periodic, aperiodic, and sporadic behaviors in their light curves. We show a modified version of the fast χ2 periodogram algorithm (Fχ2) and change-point analysis as tools for detecting and assessing the significance of periodic and non-periodic variations. The benefits of our new photometry and analysis methods are evident. A total of 2,306 stars exhibit convincing variations that are induced by flares, pulsations, eclipses, starspots, and unknown causes in some cases. This represents a 60% increase in the number of variables known in this field. Moreover, 30 of the previously identified variables are found to be false positives resulting from time-dependent systematic effects. The new catalog includes 61 eclipsing binary systems, 92 multiperiodic variable stars, 132 aperiodic variables, and 436 flare stars, as well as several hundreds of rotating variables. Based on extended and improved catalog of variables, we investigate the basic properties (e.g., period, amplitude, type) of all variables. The catalog can be accessed through the web interface (http://stardb.yonsei.ac.kr/).

CONTROLLING INFLUENCE OF MAGNETIC FIELD ON SOLAR WIND OUTFLOW: AN INVESTIGATION USING CURRENT SHEET SOURCE SURFACE MODEL

DOE Office of Scientific and Technical Information (OSTI.GOV)

Poduval, B., E-mail: bpoduval@spacescience.org

2016-08-10

This Letter presents the results of an investigation into the controlling influence of large-scale magnetic field of the Sun in determining the solar wind outflow using two magnetostatic coronal models: current sheet source surface (CSSS) and potential field source surface. For this, we made use of the Wang and Sheeley inverse correlation between magnetic flux expansion rate (FTE) and observed solar wind speed (SWS) at 1 au. During the period of study, extended over solar cycle 23 and beginning of solar cycle 24, we found that the coefficients of the fitted quadratic equation representing the FTE–SWS inverse relation exhibited significantmore » temporal variation, implying the changing pattern of the influence of FTE on SWS over time. A particularly noteworthy feature is an anomaly in the behavior of the fitted coefficients during the extended minimum, 2008–2010 (CRs 2073–2092), which is considered due to the particularly complex nature of the solar magnetic field during this period. However, this variation was significant only for the CSSS model, though not a systematic dependence on the phase of the solar cycle. Further, we noticed that the CSSS model demonstrated better solar wind prediction during the period of study, which we attribute to the treatment of volume and sheet currents throughout the corona and the more accurate tracing of footpoint locations resulting from the geometry of the model.« less

Paleocene decapod Crustacea from northeastern Mexico: Additions to biostratigraphy and diversity

NASA Astrophysics Data System (ADS)

Martínez-Díaz, José Luis; Aguillón-Martínez, Martha Carolina; Luque, Javier; Vega, Francisco J.

2017-03-01

New decapod specimens from mid-Paleocene shallow marine deposits of NE Mexico represents an important addition to the diversity, paleobiogeography and evolution of the Crustacea record. In this work, we describe additions to the decapod assemblage from the Paleocene (Selandian) Rancho Nuevo Formation (Difunta Group, Parras Basin, Coahuila). Due to the evident size differences with other decapod assemblages, we compare the new assemblage with those from the Lower Paleocene (Danian) Mexia Clay Member of the Wills Point Formation, Texas, and the Lower Eocene (Ypresian) El Bosque Formation in Chiapas. Species reported from the mid-Paleocene (Selandian) assemblage of the Porters Creek Formation (Alabama), are correlatable to the decapod species from NE Mexico in age, size and systematic composition. The erymid lobster Enoploclytia gardnerae (Rathbun, 1935) is represented by several carapaces and chelae remains. One isolated palm of Callianassidae is included. Numerous carapaces of Linuparus wilcoxensis Rathbun, 1935 are described, representing the most abundant lobster. A new record for the raninid Notopoides sp., and presence of Quasilaeviranina sp. cf. arzignagnensis and Quasilaeviranina ovalis are here reported. New raninids, Claudioranina latacantha sp. nov. and Claudioranina sp. (Cyrtorhininae) are also part of this assemblage. Paraverrucoides alabamensis (Rathbun, 1935), and Tehuacana americana (Rathbun, 1935) are represented by several carapaces exhibiting intraspecific morphological variation. Different sizes among the Early and Middle Paleocene and Early Eocene decapod populations suggests a possible effect of variation in seawater temperatures and/or a Lilliput effect after the K/Pg event.

High-resolution record of pyrogenic polycyclic aromatic hydrocarbon deposition during the 20th century.

PubMed

Lima, Ana Lúcia C; Eglinton, Timothy I; Reddy, Christopher M

2003-01-01

A high-resolution record of polycyclic aromatic hydrocarbon (PAH) deposition in Rhode Island over the past approximately 180 years was constructed using a sediment core from the anoxic Pettaquamscutt River basin. The record showed significantly more structure than has hitherto been reported and revealed four distinct maxima in PAH flux. The characteristic increase in PAH flux at the turn of the 20th century was captured in detail, leading to an initial maximum prior to the Great Depression. The overall peak in PAH flux in the 1950s was followed by a maximum that immediately preceded the 1973 Organization of Petroleum Exporting Countries (OPEC) oil embargo. During the most recent portion of the record, an abrupt increase in PAH flux between 1996 and 1999 has been found to follow a period of near constant fluxes. Because source-diagnostic ratios indicate that petrogenic inputs are minor throughout the record, these trends are interpreted in terms of past variations in the magnitude and type of combustion processes. For the most recent PAH maximum, energy consumption data suggest that diesel fuel combustion, and hence traffic of heavier vehicles, is the most probable cause for the increase in PAH flux. Systematic variations in the relative abundance of individual PAHs in conjunction with the above changes in flux are interpreted in relation to the evolution of combustion processes. Coronene, retene, and perylene are notable exceptions, exhibiting unique down-core profiles.

Birth seasonality and pattern in black-and-white snub-nosed monkeys (Rhinopithecus bieti) at Mt. Lasha, Yunnan.

PubMed

Li, Jin-Fa; He, Yu-Chao; Huang, Zhi-Pang; Wang, Shuang-Jin; Xiang, Zuo-Fu; Zhao, Juan-Jun; Xiao, Wen; Cui, Liang-Wei

2014-11-18

Seasonal variation in environmental factors is vital to the regulation of seasonal reproduction in primates. Consequently, long-term systematic data is necessary to clarify the birth seasonality and pattern of primates in highly seasonal environments. This study indicated that black-and-white snub-nosed monkeys (Rhinopithecus bieti) at Mt. Lasha exhibited strict birth seasonality with a pulse model. Infants were born with a certain degree of synchronization. Birth distribution showed three birth peaks, and the birth pattern showed a "V" style in even-numbered years and a gradual increase in odd-numbered years. The beginning date, end date and median birth date were earlier in even-numbered years than those in odd-numbered years. The higher latitude of their habitats, earlier birth date, shorter birth period, fewer birth peaks and stronger birth synchrony might be adaptations for strongly seasonal variation in climate and food resources. After the summer solstice when daylight length began to gradually shorten, R. bieti at Mt. Lasha started to breed during the period with the highest environmental temperature and food availability, which implied that photoperiod may be the proximate factor triggering the onset of estrus and mating. It appears that R. bieti coincided conception and mid-lactation with the peak in staple foods, and weaning with the peak in high quality of foods. Thus, food availability was the ultimate factor regulating reproductive seasonality, and photoperiod was the proximate factor fine-turning the coordination between seasonal breeding and food availability.

Perceived Surface Slant Is Systematically Biased in the Actively-Generated Optic Flow

PubMed Central

Fantoni, Carlo; Caudek, Corrado; Domini, Fulvio

2012-01-01

Humans make systematic errors in the 3D interpretation of the optic flow in both passive and active vision. These systematic distortions can be predicted by a biologically-inspired model which disregards self-motion information resulting from head movements (Caudek, Fantoni, & Domini 2011). Here, we tested two predictions of this model: (1) A plane that is stationary in an earth-fixed reference frame will be perceived as changing its slant if the movement of the observer's head causes a variation of the optic flow; (2) a surface that rotates in an earth-fixed reference frame will be perceived to be stationary, if the surface rotation is appropriately yoked to the head movement so as to generate a variation of the surface slant but not of the optic flow. Both predictions were corroborated by two experiments in which observers judged the perceived slant of a random-dot planar surface during egomotion. We found qualitatively similar biases for monocular and binocular viewing of the simulated surfaces, although, in principle, the simultaneous presence of disparity and motion cues allows for a veridical recovery of surface slant. PMID:22479473

Diurnal variation in ruminal pH on the digestibility of highly digestible perennial ryegrass during continuous culture fermentation.

PubMed

Wales, W J; Kolver, E S; Thorne, P L; Egan, A R

2004-06-01

Dairy cows grazing high-digestibility pastures exhibit pronounced diurnal variation in ruminal pH, with pH being below values considered optimal for digestion. Using a dual-flow continuous culture system, the hypothesis that minimizing diurnal variation in pH would improve digestion of pasture when pH was low, but not at a higher pH, was tested. Four treatments were imposed, with pH either allowed to exhibit normal diurnal variation around an average pH of 6.1 or 5.6, or maintained at constant pH. Digesta samples were collected during the last 3 d of each of four, 9-d experimental periods. A constant pH at 5.6 compared with a constant pH of 6.1 reduced the digestibility of organic matter (OM), neutral detergent (NDF), and acid detergent fiber (ADF) by 7, 14, and 21%, respectively. When pH was allowed to vary (averaging 5.6), digestion of OM, NDF, and ADF were reduced by 15,30, and 36%, respectively, compared with pH varying at 6.1. There was little difference in digestion parameters when pH was either constant or varied with an average pH of 6.1. However, when average pH was 5.6, maintaining a constant pH significantly increased digestion of OM, NDF, and ADF by 5, 25, and 24% compared with a pH that exhibited normal diurnal variation. These in vitro results show that gains in digestibility and potential milk production can be made by minimizing diurnal variation in ruminal pH, but only when ruminal pH is low (5.6). However, larger gains in productivity can be achieved by increasing average daily ruminal pH from 5.6 to 6.1.

A Study of Poisson's Ratio in the Yield Region

NASA Technical Reports Server (NTRS)

Gerard, George; Wildhorn, Sorrel

1952-01-01

In the yield region of the stress-strain curve the variation in Poisson's ratio from the elastic to the plastic value is most pronounced. This variation was studied experimentally by a systematic series of tests on several aluminum alloys. The tests were conducted under simple tensile and compressive loading along three orthogonal axes. A theoretical variation of Poisson's ratio for an orthotropic solid was obtained from dilatational considerations. The assumptions used in deriving the theory were examined by use of the test data and were found to be in reasonable agreement with experimental evidence.

Synthesis: Intertwining product and process

NASA Technical Reports Server (NTRS)

Weiss, David M.

1990-01-01

Synthesis is a proposed systematic process for rapidly creating different members of a program family. Family members are described by variations in their requirements. Requirements variations are mapped to variations on a standard design to generate production quality code and documentation. The approach is made feasible by using principles underlying design for change. Synthesis incorporates ideas from rapid prototyping, application generators, and domain analysis. The goals of Synthesis and the Synthesis process are discussed. The technology needed and the feasibility of the approach are also briefly discussed. The status of current efforts to implement Synthesis methodologies is presented.

A systematical rheological study of polysaccharide from Sophora alopecuroides L. seeds.

PubMed

Wu, Yan; Guo, Rui; Cao, Nannan; Sun, Xiangjun; Sui, Zhongquan; Guo, Qingbin

2018-01-15

The rheological properties of polysaccharide (SAP) from Sophora alopecuroides L. seeds were systematically investigated by fitting different models. The steady flow testing indicated that SAP exhibited shear-thinning behaviors, which were enhanced with increasing concentration and decreasing temperature. This was demonstrated quantitatively by Williamson and Arrhenius models. According to the generalized Morris equation, SAP exhibited random coil conformation with the potential to form weak gel-like network. On the other hand, multiple results of dynamic tests confirmed the viscoelastic properties of SAP, showing oscillatory behaviors between a dilute solution and an elastic gel. Furthermore, SAP solutions were thermorheologically stable without remarkable energetic interactions or structural heterogeneity, since their rheological patterns were successfully applied to Time-temperature superposition (TTS) principle, modified Cole-Cole analysis and Cox-Merz rule. Copyright © 2017 Elsevier Ltd. All rights reserved.

Chemical Evidence for Vertical Transport from Magma Chambers to the Surface During Mid-Ocean Ridge Volcanic Eruptions

NASA Astrophysics Data System (ADS)

Sinton, J. M.; Rubin, K. H.

2009-12-01

Many mid-ocean ridge eruptions show significant internal chemical heterogeneity; in general, the amount of chemical heterogeneity within eruptions scales with erupted volume. These variations reflect magmatic processes occurring in magma reservoirs prior to or possibly during eruption. For example, systematic variations in Mg# with along-axis distance in the early 90’s Aldo-Kihi (S. EPR near 17.5°S), 1996 N. Gorda, 1993 Co-Axial (Juan de Fuca Ridge), and 1991-2 and 2005-6 9°50’N EPR eruptions is unlikely to be related to fractionation during emplacement, and rather reflects variations in sub-axial magma reservoirs prior to eruption. Such variations are inconsistent with well-mixed sub-axial reservoirs and, in some cases, require relatively long-lived, systematic variations in reservoir temperatures along axis. Chemical heterogeneity within the Aldo-Kihi eruption preserves spatial variations in mantle-derived isotopic and trace element ratios with implications for the temporal and spatial scales of magma injections to the crust and along-axis mixing within shallow reservoirs. These spatial variations are difficult to reconcile with significant (> ~1 km) along-axis magma transport, as are striking correlations of chemical compositions with surface geological discontinuities or seismically imaged sub-axial magma chamber reflectors in the S. Hump (S. EPR), 9°50’N EPR, N. Gorda and 1975-1984 Krafla (N. Iceland) eruptive units. Rather, spatial correlations between surface lava compositions and sub-axial magma chamber properties or long-lived axial morphology suggest that most of the erupted magma was transported nearly vertically from the underlying reservoirs to the surface during these eruptions. In the case of the Krafla eruption, coincident deformation suggests a component of lateral melt migration at depth, despite chemical evidence for vertical transport of erupted lava from more than one chemical reservoir. In addition, along-ridge movement of earthquake epicenters during the 1992 Co-Axial and 1996 Gorda eruptions implies migration of stress release during these eruptions, even though vertical transport better explains chemical patterns. The nature of transport for most eruptions is unclear because of lack of systematic chemical patterns; this presentation emphasizes those cases where vertical transport appears to be required.

All-Polymer Solar Cell Performance Optimized via Systematic Molecular Weight Tuning of Both Donor and Acceptor Polymers.

PubMed

Zhou, Nanjia; Dudnik, Alexander S; Li, Ting I N G; Manley, Eric F; Aldrich, Thomas J; Guo, Peijun; Liao, Hsueh-Chung; Chen, Zhihua; Chen, Lin X; Chang, Robert P H; Facchetti, Antonio; Olvera de la Cruz, Monica; Marks, Tobin J

2016-02-03

The influence of the number-average molecular weight (Mn) on the blend film morphology and photovoltaic performance of all-polymer solar cells (APSCs) fabricated with the donor polymer poly[5-(2-hexyldodecyl)-1,3-thieno[3,4-c]pyrrole-4,6-dione-alt-5,5-(2,5-bis(3-dodecylthiophen-2-yl)thiophene)] (PTPD3T) and acceptor polymer poly{[N,N'-bis(2-octyldodecyl)naphthalene-1,4,5,8-bis(dicarboximide)-2,6-diyl]-alt-5,5'-(2,2'-bithiophene)} (P(NDI2OD-T2); N2200) is systematically investigated. The Mn effect analysis of both PTPD3T and N2200 is enabled by implementing a polymerization strategy which produces conjugated polymers with tunable Mns. Experimental and coarse-grain modeling results reveal that systematic Mn variation greatly influences both intrachain and interchain interactions and ultimately the degree of phase separation and morphology evolution. Specifically, increasing Mn for both polymers shrinks blend film domain sizes and enhances donor-acceptor polymer-polymer interfacial areas, affording increased short-circuit current densities (Jsc). However, the greater disorder and intermixed feature proliferation accompanying increasing Mn promotes charge carrier recombination, reducing cell fill factors (FF). The optimized photoactive layers exhibit well-balanced exciton dissociation and charge transport characteristics, ultimately providing solar cells with a 2-fold PCE enhancement versus devices with nonoptimal Mns. Overall, it is shown that proper and precise tuning of both donor and acceptor polymer Mns is critical for optimizing APSC performance. In contrast to reports where maximum power conversion efficiencies (PCEs) are achieved for the highest Mns, the present two-dimensional Mn optimization matrix strategy locates a PCE "sweet spot" at intermediate Mns of both donor and acceptor polymers. This study provides synthetic methodologies to predictably access conjugated polymers with desired Mn and highlights the importance of optimizing Mn for both polymer components to realize the full potential of APSC performance.

All-Polymer Solar Cell Performance Optimized via Systematic Molecular Weight Tuning of Both Donor and Acceptor Polymers

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhou, Nanjia; Dudnik, Alexander S.; Li, Ting I. N. G.

2016-01-21

The influence of the number-average molecular weight (Mn) on the blend film morphology and photovoltaic performance of all-polymer solar cells (APSCs) fabricated with the donor polymer poly[5-(2-hexyldodecyl)-1,3-thieno[3,4-c]pyrrole-4,6-dione-alt-5,5-(2,5-bis(3-dodecylthiophen-2-yl)thiophene)] (PTPD3T) and acceptor polymer poly{[N,N'-bis(2-octyldodecyl)naphthalene-1,4,5,8-bis(dicarboximide)-2,6-diyl]-alt-5,5'-(2,2'-bithiophene)} (P(NDI2OD-T2); N2200) is systematically investigated. The Mn effect analysis of both PTPD3T and N2200 is enabled by implementing a polymerization strategy which produces conjugated polymers with tunable Mns. Experimental and coarse-grain modeling results reveal that systematic Mn variation greatly influences both intrachain and interchain interactions and ultimately the degree of phase separation and morphology evolution. Specifically, increasing Mn for both polymers shrinks blend film domain sizes and enhancesmore » donor–acceptor polymer–polymer interfacial areas, affording increased short-circuit current densities (Jsc). However, the greater disorder and intermixed feature proliferation accompanying increasing Mn promotes charge carrier recombination, reducing cell fill factors (FF). The optimized photoactive layers exhibit well-balanced exciton dissociation and charge transport characteristics, ultimately providing solar cells with a 2-fold PCE enhancement versus devices with nonoptimal Mns. Overall, it is shown that proper and precise tuning of both donor and acceptor polymer Mns is critical for optimizing APSC performance. In contrast to reports where maximum power conversion efficiencies (PCEs) are achieved for the highest Mns, the present two-dimensional Mn optimization matrix strategy locates a PCE “sweet spot” at intermediate Mns of both donor and acceptor polymers. This study provides synthetic methodologies to predictably access conjugated polymers with desired Mn and highlights the importance of optimizing Mn for both polymer components to realize the full potential of APSC performance.« less

The permafrost carbon inventory on the Tibetan Plateau: a new evaluation using deep sediment cores.

PubMed

Ding, Jinzhi; Li, Fei; Yang, Guibiao; Chen, Leiyi; Zhang, Beibei; Liu, Li; Fang, Kai; Qin, Shuqi; Chen, Yongliang; Peng, Yunfeng; Ji, Chengjun; He, Honglin; Smith, Pete; Yang, Yuanhe

2016-08-01

The permafrost organic carbon (OC) stock is of global significance because of its large pool size and the potential positive feedback to climate warming. However, due to the lack of systematic field observations and appropriate upscaling methodologies, substantial uncertainties exist in the permafrost OC budget, which limits our understanding of the fate of frozen carbon in a warming world. In particular, the lack of comprehensive estimates of OC stocks across alpine permafrost means that current knowledge on this issue remains incomplete. Here, we evaluated the pool size and spatial variations of permafrost OC stock to 3 m depth on the Tibetan Plateau by combining systematic measurements from a substantial number of pedons (i.e. 342 three-metre-deep cores and 177 50-cm-deep pits) with a machine learning technique (i.e. support vector machine, SVM). We also quantified uncertainties in permafrost carbon budget by conducting Monte Carlo simulations. Our results revealed that the combination of systematic measurements with the SVM model allowed spatially explicit estimates to be made. The OC density (OC amount per unit area, OCD) exhibited a decreasing trend from the south-eastern to the north-western plateau, with the exception that OCD in the swamp meadow was substantially higher than that in surrounding regions. Our results also demonstrated that Tibetan permafrost stored a large amount of OC in the top 3 m, with the median OC pool size being 15.31 Pg C (interquartile range: 13.03-17.77 Pg C). 44% of OC occurred in deep layers (i.e. 100-300 cm), close to the proportion observed across the northern circumpolar permafrost region. The large carbon pool size together with significant permafrost thawing suggests a risk of carbon emissions and positive climate feedback across the Tibetan alpine permafrost region. © 2016 John Wiley & Sons Ltd.

Systematics of the K X-Ray Multiplicity for Transitional Nuclei with A~=200

NASA Astrophysics Data System (ADS)

Karwowski, H. J.; Vigdor, S. E.; Jacobs, W. W.; Throwe, T. G.; Wark, D. L.; Kailas, S.; Singh, P. P.; Soga, F.; Ward, T. E.; Wiggins, J.

1981-11-01

Measurements of the multiplicity of K x rays accompanying (Li,xn) reactions to residual nuclei with Z~80 exhibit plateaus of high and constant multiplicity for neutron numbers between 110 and 120, with rapid falloff for both smaller and larger N. A proposed explanation for this systematic behavior assumes that strongly coupled, high-K rotational bands are a much more general feature of this transitional mass region than existing data indicate.

Abundant Gene-by-Environment Interactions in Gene Expression Reaction Norms to Copper within Saccharomyces cerevisiae

PubMed Central

Hodgins-Davis, Andrea; Adomas, Aleksandra B.; Warringer, Jonas; Townsend, Jeffrey P.

2012-01-01

Genetic variation for plastic phenotypes potentially contributes phenotypic variation to populations that can be selected during adaptation to novel ecological contexts. However, the basis and extent of plastic variation that manifests in diverse environments remains elusive. Here, we characterize copper reaction norms for mRNA abundance among five Saccharomyces cerevisiae strains to 1) describe population variation across the full range of ecologically relevant copper concentrations, from starvation to toxicity, and 2) to test the hypothesis that plastic networks exhibit increased population variation for gene expression. We find that although the vast majority of the variation is small in magnitude (considerably <2-fold), not just some, but most genes demonstrate variable expression across environments, across genetic backgrounds, or both. Plastically expressed genes included both genes regulated directly by copper-binding transcription factors Mac1 and Ace1 and genes indirectly responding to the downstream metabolic consequences of the copper gradient, particularly genes involved in copper, iron, and sulfur homeostasis. Copper-regulated gene networks exhibited more similar behavior within the population in environments where those networks have a large impact on fitness. Nevertheless, expression variation in genes like Cup1, important to surviving copper stress, was linked with variation in mitotic fitness and in the breadth of differential expression across the genome. By revealing a broader and deeper range of population variation, our results provide further evidence for the interconnectedness of genome-wide mRNA levels, their dependence on environmental context and genetic background, and the abundance of variation in gene expression that can contribute to future evolution. PMID:23019066

Genotype-by-environment interactions leads to variable selection on life-history strategy in Common Evening Primrose (Oenothera biennis).

PubMed

Johnson, M T J

2007-01-01

Monocarpic plant species, where reproduction is fatal, frequently exhibit variation in the length of their prereproductive period prior to flowering. If this life-history variation in flowering strategy has a genetic basis, genotype-by-environment interactions (G x E) may maintain phenotypic diversity in flowering strategy. The native monocarpic plant Common Evening Primrose (Oenothera biennis L., Onagraceae) exhibits phenotypic variation for annual vs. biennial flowering strategies. I tested whether there was a genetic basis to variation in flowering strategy in O. biennis, and whether environmental variation causes G x E that imposes variable selection on flowering strategy. In a field experiment, I randomized more than 900 plants from 14 clonal families (genotypes) into five distinct habitats that represented a natural productivity gradient. G x E strongly affected the lifetime fruit production of O. biennis, with the rank-order in relative fitness of genotypes changing substantially between habitats. I detected genetic variation in annual vs. biennial strategies in most habitats, as well as a G x E effect on flowering strategy. This variation in flowering strategy was correlated with genetic variation in relative fitness, and phenotypic and genotypic selection analyses revealed that environmental variation resulted in variable directional selection on annual vs. biennial strategies. Specifically, a biennial strategy was favoured in moderately productive environments, whereas an annual strategy was favoured in low-productivity environments. These results highlight the importance of variable selection for the maintenance of genetic variation in the life-history strategy of a monocarpic plant.

Adaptive latitudinal variation in Common Blackbird Turdus merula nest characteristics

PubMed Central

Mainwaring, Mark C; Deeming, D Charles; Jones, Chris I; Hartley, Ian R

2014-01-01

Nest construction is taxonomically widespread, yet our understanding of adaptive intraspecific variation in nest design remains poor. Nest characteristics are expected to vary adaptively in response to predictable variation in spring temperatures over large spatial scales, yet such variation in nest design remains largely overlooked, particularly amongst open-cup-nesting birds. Here, we systematically examined the effects of latitudinal variation in spring temperatures and precipitation on the morphology, volume, composition, and insulatory properties of open-cup-nesting Common Blackbirds’ Turdus merula nests to test the hypothesis that birds living in cooler environments at more northerly latitudes would build better insulated nests than conspecifics living in warmer environments at more southerly latitudes. As spring temperatures increased with decreasing latitude, the external diameter of nests decreased. However, as nest wall thickness also decreased, there was no variation in the diameter of the internal nest cups. Only the mass of dry grasses within nests decreased with warmer temperatures at lower latitudes. The insulatory properties of nests declined with warmer temperatures at lower latitudes and nests containing greater amounts of dry grasses had higher insulatory properties. The insulatory properties of nests decreased with warmer temperatures at lower latitudes, via changes in morphology (wall thickness) and composition (dry grasses). Meanwhile, spring precipitation did not vary with latitude, and none of the nest characteristics varied with spring precipitation. This suggests that Common Blackbirds nesting at higher latitudes were building nests with thicker walls in order to counteract the cooler temperatures. We have provided evidence that the nest construction behavior of open-cup-nesting birds systematically varies in response to large-scale spatial variation in spring temperatures. PMID:24683466

Adaptive latitudinal variation in Common Blackbird Turdus merula nest characteristics.

PubMed

Mainwaring, Mark C; Deeming, D Charles; Jones, Chris I; Hartley, Ian R

2014-03-01

Nest construction is taxonomically widespread, yet our understanding of adaptive intraspecific variation in nest design remains poor. Nest characteristics are expected to vary adaptively in response to predictable variation in spring temperatures over large spatial scales, yet such variation in nest design remains largely overlooked, particularly amongst open-cup-nesting birds. Here, we systematically examined the effects of latitudinal variation in spring temperatures and precipitation on the morphology, volume, composition, and insulatory properties of open-cup-nesting Common Blackbirds' Turdus merula nests to test the hypothesis that birds living in cooler environments at more northerly latitudes would build better insulated nests than conspecifics living in warmer environments at more southerly latitudes. As spring temperatures increased with decreasing latitude, the external diameter of nests decreased. However, as nest wall thickness also decreased, there was no variation in the diameter of the internal nest cups. Only the mass of dry grasses within nests decreased with warmer temperatures at lower latitudes. The insulatory properties of nests declined with warmer temperatures at lower latitudes and nests containing greater amounts of dry grasses had higher insulatory properties. The insulatory properties of nests decreased with warmer temperatures at lower latitudes, via changes in morphology (wall thickness) and composition (dry grasses). Meanwhile, spring precipitation did not vary with latitude, and none of the nest characteristics varied with spring precipitation. This suggests that Common Blackbirds nesting at higher latitudes were building nests with thicker walls in order to counteract the cooler temperatures. We have provided evidence that the nest construction behavior of open-cup-nesting birds systematically varies in response to large-scale spatial variation in spring temperatures.

Spatial Analysis of Hospital Incidence and in Hospital Mortality of Abdominal Aortic Aneurysms in Germany: Secondary Data Analysis of Nationwide Hospital Episode (DRG) Data.

PubMed

Kuehnl, Andreas; Salvermoser, Michael; Erk, Alexander; Trenner, Matthias; Schmid, Volker; Eckstein, Hans-Henning

2018-06-01

This study aimed to analyze the spatial distribution and regional variation of the hospital incidence and in hospital mortality of abdominal aortic aneurysms (AAA) in Germany. German DRG statistics (2011-2014) were analysed. Patients with ruptured AAA (rAAA, I71.3, treated or not) and patients with non-ruptured AAA (nrAAA, I71.4, treated by open or endovascular aneurysm repair) were included. Age, sex, and risk standardisation was done using standard statistical procedures. Regional variation was quantified using systematic component of variation. To analyse spatial auto-correlation and spatial pattern, global Moran's I and Getis-Ord Gi* were calculated. A total of 50,702 cases were included. Raw hospital incidence of AAA was 15.7 per 100,000 inhabitants (nrAAA 13.1; all rAAA 2.7; treated rAAA 1.6). The standardised hospital incidence of AAA ranged from 6.3 to 30.3 per 100,000. Systematic component of variation proportion was 96% in nrAAA and 55% in treated rAAA. Incidence rates of all AAA were significantly clustered with above average values in the northwestern parts of Germany and below average values in the south and eastern regions. Standardised mortality of nrAAA ranged from 1.7% to 4.3%, with that of treated rAAA ranging from 28% to 52%. Regional variation and spatial distribution of standardised mortality was not different from random. There was significant regional variation and clustering of the hospital incidence of AAA in Germany, with higher rates in the northwest and lower rates in the southeast. There was no significant variation in standardised (age/sex/risk) mortality between counties. Copyright © 2018. Published by Elsevier B.V.

Perceptual Compensation Is Correlated with Individuals' “Autistic” Traits: Implications for Models of Sound Change

PubMed Central

Yu, Alan C. L.

2010-01-01

Variation is a ubiquitous feature of speech. Listeners must take into account context-induced variation to recover the interlocutor's intended message. When listeners fail to normalize for context-induced variation properly, deviant percepts become seeds for new perceptual and production norms. In question is how deviant percepts accumulate in a systematic fashion to give rise to sound change (i.e., new pronunciation norms) within a given speech community. The present study investigated subjects' classification of /s/ and // before /a/ or /u/ spoken by a male or a female voice. Building on modern cognitive theories of autism-spectrum condition, which see variation in autism-spectrum condition in terms of individual differences in cognitive processing style, we established a significant correlation between individuals' normalization for phonetic context (i.e., whether the following vowel is /a/ or /u/) and talker voice variation (i.e., whether the talker is male or female) in speech and their “autistic” traits, as measured by the Autism Spectrum Quotient (AQ). In particular, our mixed-effect logistic regression models show that women with low AQ (i.e., the least “autistic”) do not normalize for phonetic coarticulation as much as men and high AQ women. This study provides first direct evidence that variability in human's ability to compensate for context-induced variations in speech perceptually is governed by the individual's sex and cognitive processing style. These findings lend support to the hypothesis that the systematic infusion of new linguistic variants (i.e., the deviant percepts) originate from a sub-segment of the speech community that consistently under-compensates for contextual variation in speech. PMID:20808859

Distinguishing the rates of gene activation from phenotypic variations.

PubMed

Chen, Ye; Lv, Cheng; Li, Fangting; Li, Tiejun

2015-06-18

Stochastic genetic switching driven by intrinsic noise is an important process in gene expression. When the rates of gene activation/inactivation are relatively slow, fast, or medium compared with the synthesis/degradation rates of mRNAs and proteins, the variability of protein and mRNA levels may exhibit very different dynamical patterns. It is desirable to provide a systematic approach to identify their key dynamical features in different regimes, aiming at distinguishing which regime a considered gene regulatory network is in from their phenotypic variations. We studied a gene expression model with positive feedbacks when genetic switching rates vary over a wide range. With the goal of providing a method to distinguish the regime of the switching rates, we first focus on understanding the essential dynamics of gene expression system in different cases. In the regime of slow switching rates, we found that the effective dynamics can be reduced to independent evolutions on two separate layers corresponding to gene activation and inactivation states, and the transitions between two layers are rare events, after which the system goes mainly along deterministic ODE trajectories on a particular layer to reach new steady states. The energy landscape in this regime can be well approximated by using Gaussian mixture model. In the regime of intermediate switching rates, we analyzed the mean switching time to investigate the stability of the system in different parameter ranges. We also discussed the case of fast switching rates from the viewpoint of transition state theory. Based on the obtained results, we made a proposal to distinguish these three regimes in a simulation experiment. We identified the intermediate regime from the fact that the strength of cellular memory is lower than the other two cases, and the fast and slow regimes can be distinguished by their different perturbation-response behavior with respect to the switching rates perturbations. We proposed a simulation experiment to distinguish the slow, intermediate and fast regimes, which is the main point of our paper. In order to achieve this goal, we systematically studied the essential dynamics of gene expression system when the switching rates are in different regimes. Our theoretical understanding provides new insights on the gene expression experiments.

Temperature and electrical memory of polymer fibers

NASA Astrophysics Data System (ADS)

Yuan, Jinkai; Zakri, Cécile; Grillard, Fabienne; Neri, Wilfrid; Poulin, Philippe

2014-05-01

We report in this work studies of the shape memory behavior of polymer fibers loaded with carbon nanotubes or graphene flakes. These materials exhibit enhanced shape memory properties with the generation of a giant stress upon shape recovery. In addition, they exhibit a surprising temperature memory with a peak of generated stress at a temperature nearly equal to the temperature of programming. This temperature memory is ascribed to the presence of dynamical heterogeneities and to the intrinsic broadness of the glass transition. We present recent experiments related to observables other than mechanical properties. In particular nanocomposite fibers exhibit variations of electrical conductivity with an accurate memory. Indeed, the rate of conductivity variations during temperature changes reaches a well defined maximum at a temperature equal to the temperature of programming. Such materials are promising for future actuators that couple dimensional changes with sensing electronic functionalities.

Runoff response to climate change and human activities in a typical karst watershed, SW China.

PubMed

Xu, Yan; Wang, Shijie; Bai, Xiaoyong; Shu, Dongcai; Tian, Yichao

2018-01-01

This study aims to reveal the runoff variation characteristics of long time series in a karst region, analyse comprehensively its different driving factors, and estimate quantitatively the contribution rates of climate change and human activities to net runoff variation. Liudong river basin, a typical karst watershed in southwest China, is the study site. Statistical methods, such as linear fitting, the Morlet wavelet analysis, normalized curve and double mass curve, are applied to analyse the runoff of the watershed. Results show that the runoff in the karst watershed during the research period exhibits a three-stage change and the abrupt change points are the years 1981 and 2007: (1) 1968-1980, the runoff initially exhibited a trend of sustained decreasing and then an abrupt fluctuation. The runoff was obviously destroyed through precipitation-producing processes. Improper land utilisation and serious forest and grass destruction intensified the fluctuation variation amplitude of the runoff. (2) 1981-2006, the changing processes of runoff and precipitation exhibited good synchronism. Precipitation significantly affected runoff variation and human activities had a slight interference degree. (3) 2007-2013, the fluctuation range of runoff was considerably smaller than that of precipitation. The significant growth of forest and grassland areas and the increase in water consumption mitigated runoff fluctuation and greatly diminished runoff variation amplitude. According to calculation, the relative contribution rates of precipitation and human activities to net runoff variation with 1981-2007 as the reference period were -81% and 181% in average, respectively, during 1968-1980, and -117% and 217% in average, respectively, during 2007-2013. In general, the analysis of runoff variation trend and of the contribution rate of its main influencing factors in the typical karst watershed for nearly half a century may be significant to solve the drought problem in the karst region and for the sustainable development of the drainage basin.

Runoff response to climate change and human activities in a typical karst watershed, SW China

PubMed Central

Xu, Yan; Wang, Shijie; Shu, Dongcai; Tian, Yichao

2018-01-01

This study aims to reveal the runoff variation characteristics of long time series in a karst region, analyse comprehensively its different driving factors, and estimate quantitatively the contribution rates of climate change and human activities to net runoff variation. Liudong river basin, a typical karst watershed in southwest China, is the study site. Statistical methods, such as linear fitting, the Morlet wavelet analysis, normalized curve and double mass curve, are applied to analyse the runoff of the watershed. Results show that the runoff in the karst watershed during the research period exhibits a three-stage change and the abrupt change points are the years 1981 and 2007: (1) 1968–1980, the runoff initially exhibited a trend of sustained decreasing and then an abrupt fluctuation. The runoff was obviously destroyed through precipitation-producing processes. Improper land utilisation and serious forest and grass destruction intensified the fluctuation variation amplitude of the runoff. (2) 1981–2006, the changing processes of runoff and precipitation exhibited good synchronism. Precipitation significantly affected runoff variation and human activities had a slight interference degree. (3) 2007–2013, the fluctuation range of runoff was considerably smaller than that of precipitation. The significant growth of forest and grassland areas and the increase in water consumption mitigated runoff fluctuation and greatly diminished runoff variation amplitude. According to calculation, the relative contribution rates of precipitation and human activities to net runoff variation with 1981–2007 as the reference period were −81% and 181% in average, respectively, during 1968–1980, and −117% and 217% in average, respectively, during 2007–2013. In general, the analysis of runoff variation trend and of the contribution rate of its main influencing factors in the typical karst watershed for nearly half a century may be significant to solve the drought problem in the karst region and for the sustainable development of the drainage basin. PMID:29494602

Effect of TMP variables upon structure and properties in ODS alloy HDA 8077 sheet. [ThermoMechanical Processing of Oxide Dispersion Strengthened nickel alloy

NASA Technical Reports Server (NTRS)

Rothman, M. F.; Tawancy, H. M.

1980-01-01

The effects of oxide content level and variations in thermomechanical processing upon the final structure and properties of HDA 8077 sheet have been systematically examined. It was found that creep strength and formability are substantially influenced by both oxide content and TMP schedule. Variations in creep properties obtained appear to correlate with observed microstructures.

A Primary Care Workload Production Model for Estimating Relative Value Unit Output

DTIC Science & Technology

2011-03-01

for Medicare and Medicaid Services, Office of the Actuary , National Health Statistics Group; and U.S. Department of Commerce, Bureau of Economic...The systematic variation in a relationship can be represented by a mathematical expression, whereas stochastic variation cannot. Further, stochastic...expressed mathematically as an equation, whereby a response variable Y is fitted to a function of “regressor variables and parameters” (SAS©, 2010). A

Demonstration of Systematic Improvements in Application of the Variational Method to Strongly Bound Potentials

ERIC Educational Resources Information Center

Ninemire, B.; Mei, W. N.

2004-01-01

In applying the variational method, six different sets of trial wave functions are used to calculate the ground state and first excited state energies of the strongly bound potentials, i.e. V(x)=x[2m], where m = 4, 5 and 6. It is shown that accurate results can be obtained from thorough analysis of the asymptotic behaviour of the solutions.…

Assessing the Relationship Between Sexual Concordance, Sexual Attractions, and Sexual Identity in Women.

PubMed

Suschinsky, Kelly D; Dawson, Samantha J; Chivers, Meredith L

2017-01-01

On average, there is a gender difference in sexual concordance, with men exhibiting greater agreement between genital and self-reported sexual arousal, relative to women. Much less is known about the substantial variation in women's sexual concordance; women's genital and self-reported sexual responses may correlate strongly and positively, not at all, or even strongly negatively. The within-gender variation in sexual concordance suggests that individual differences may be related to sexual concordance. We examined whether sexual concordance varies as a function of sexual orientation (based on self-reported sexual attractions and sexual identity labels) in a sample (N = 76) that included exclusively androphilic, predominantly androphilic, ambiphilic, and predominantly/exclusively gynephilic women. Participants viewed sexual and nonsexual stimuli that varied by actor gender while their vaginal vasocongestion and subjective sexual responses were measured. Women's sexual concordance varied as a function of their sexual attractions; women with any degree of gynephilia exhibited higher sexual concordance than exclusively androphilic women across a variety of sexual concordance measures, and these effects were demonstrated using correlation and multi-level modeling analyses. Only sexual concordance based on overall feelings of arousal varied by sexual identity, with heterosexual women exhibiting the lowest sexual concordance. Stimulus gender significantly influenced sexual concordance for most groups of women: Ambiphilic and predominantly/exclusively gynephilic women exhibited greater sexual concordance to female stimuli and exclusively androphilic women exhibited greater sexual concordance to male stimuli. These findings suggest that sexual orientation (particularly one's degree of gynephilia) may explain some of the within-gender variation seen in women's sexual concordance.

Within-Tunnel Variations in Pressure Data for Three Transonic Wind Tunnels

NASA Technical Reports Server (NTRS)

DeLoach, Richard

2014-01-01

This paper compares the results of pressure measurements made on the same test article with the same test matrix in three transonic wind tunnels. A comparison is presented of the unexplained variance associated with polar replicates acquired in each tunnel. The impact of a significance component of systematic (not random) unexplained variance is reviewed, and the results of analyses of variance are presented to assess the degree of significant systematic error in these representative wind tunnel tests. Total uncertainty estimates are reported for 140 samples of pressure data, quantifying the effects of within-polar random errors and between-polar systematic bias errors.

A systematic review and meta-analysis on the incubation period of Campylobacteriosis.

PubMed

Awofisayo-Okuyelu, A; Hall, I; Adak, G; Hawker, J I; Abbott, S; McCARTHY, N

2017-08-01

Accurate knowledge of pathogen incubation period is essential to inform public health policies and implement interventions that contribute to the reduction of burden of disease. The incubation period distribution of campylobacteriosis is currently unknown with several sources reporting different times. Variation in the distribution could be expected due to host, transmission vehicle, and organism characteristics, however, the extent of this variation and influencing factors are unclear. The authors have undertaken a systematic review of published literature of outbreak studies with well-defined point source exposures and human experimental studies to estimate the distribution of incubation period and also identify and explain the variation in the distribution between studies. We tested for heterogeneity using I 2 and Kolmogorov-Smirnov tests, regressed incubation period against possible explanatory factors, and used hierarchical clustering analysis to define subgroups of studies without evidence of heterogeneity. The mean incubation period of subgroups ranged from 2·5 to 4·3 days. We observed variation in the distribution of incubation period between studies that was not due to chance. A significant association between the mean incubation period and age distribution was observed with outbreaks involving only children reporting an incubation of 1·29 days longer when compared with outbreaks involving other age groups.

Bold colors in a cryptic lineage: do Eastern Indigo Snakes exhibit color dimorphism?

PubMed

Deitloff, Jennifer; Johnson, Valerie M; Guyer, Craig

2013-01-01

Many species exhibit variation in the color of their scales, feathers, or fur. Various forms of natural selection, such as mimicry, crypsis, and species recognition, as well as sexual selection, can influence the evolution of color. Eastern Indigo Snakes (Drymarchon couperi), a federally threatened species, have coloration on the sides of the head and the chin that can vary from black to red or cream. Despite significant conservations efforts for this species, little is known about its biology in the field. Past researchers have proposed that the color variation on the head and chin is associated with the sex of the individual. Alternatively, color might vary among individuals because it is controlled by genes that are under natural selection or neutral evolution. We tested these alternative hypotheses by examining whether coloration of the sublabial, submaxillary, and ventral scales of this species differed by sex or among clutches. We used color spectrometry to characterize important aspects of color in two ways: by examining overall color differences across the entire color spectrum and by comparing differences within the ultraviolet, yellow, and red colorbands. We found that Eastern Indigo Snakes do not exhibit sexual dichromatism, but their coloration does vary among clutches; therefore, the pattern of sexual selection leading to sexual dichromatism observed in many squamates does not appear to play a role in the evolution and maintenance of color variation in Eastern Indigo Snakes. We suggest that future studies should focus on determining whether color variation in these snakes is determined by maternal effects or genetic components and if color is influenced by natural selection or neutral evolutionary processes. Studying species that exhibit bright colors within lineages that are not known for such coloration will contribute greatly to our understanding of the evolutionary and ecological factors that drive these differences.

Elevated temperature is more effective than elevated [CO2 ] in exposing genotypic variation in Telopea speciosissima growth plasticity: implications for woody plant populations under climate change.

PubMed

Huang, Guomin; Rymer, Paul D; Duan, Honglang; Smith, Renee A; Tissue, David T

2015-10-01

Intraspecific variation in phenotypic plasticity is a critical determinant of plant species capacity to cope with climate change. A long-standing hypothesis states that greater levels of environmental variability will select for genotypes with greater phenotypic plasticity. However, few studies have examined how genotypes of woody species originating from contrasting environments respond to multiple climate change factors. Here, we investigated the main and interactive effects of elevated [CO2 ] (CE ) and elevated temperature (TE ) on growth and physiology of Coastal (warmer, less variable temperature environment) and Upland (cooler, more variable temperature environment) genotypes of an Australian woody species Telopea speciosissima. Both genotypes were positively responsive to CE (35% and 29% increase in whole-plant dry mass and leaf area, respectively), but only the Coastal genotype exhibited positive growth responses to TE . We found that the Coastal genotype exhibited greater growth response to TE (47% and 85% increase in whole-plant dry mass and leaf area, respectively) when compared with the Upland genotype (no change in dry mass or leaf area). No intraspecific variation in physiological plasticity was detected under CE or TE , and the interactive effects of CE and TE on intraspecific variation in phenotypic plasticity were also largely absent. Overall, TE was a more effective climate factor than CE in exposing genotypic variation in our woody species. Our results contradict the paradigm that genotypes from more variable climates will exhibit greater phenotypic plasticity in future climate regimes. © 2015 John Wiley & Sons Ltd.

Systematic variation of prosthetic foot spring affects center-of-mass mechanics and metabolic cost during walking.

PubMed

Zelik, Karl E; Collins, Steven H; Adamczyk, Peter G; Segal, Ava D; Klute, Glenn K; Morgenroth, David C; Hahn, Michael E; Orendurff, Michael S; Czerniecki, Joseph M; Kuo, Arthur D

2011-08-01

Lower-limb amputees expend more energy to walk than non-amputees and have an elevated risk of secondary disabilities. Insufficient push-off by the prosthetic foot may be a contributing factor. We aimed to systematically study the effect of prosthetic foot mechanics on gait, to gain insight into fundamental prosthetic design principles. We varied a single parameter in isolation, the energy-storing spring in a prototype prosthetic foot, the controlled energy storage and return (CESR) foot, and observed the effect on gait. Subjects walked on the CESR foot with three different springs. We performed parallel studies on amputees and on non-amputees wearing prosthetic simulators. In both groups, spring characteristics similarly affected ankle and body center-of-mass (COM) mechanics and metabolic cost. Softer springs led to greater energy storage, energy return, and prosthetic limb COM push-off work. But metabolic energy expenditure was lowest with a spring of intermediate stiffness, suggesting biomechanical disadvantages to the softest spring despite its greater push-off. Disadvantages of the softest spring may include excessive heel displacements and COM collision losses. We also observed some differences in joint kinetics between amputees and non-amputees walking on the prototype foot. During prosthetic push-off, amputees exhibited reduced energy transfer from the prosthesis to the COM along with increased hip work, perhaps due to greater energy dissipation at the knee. Nevertheless, the results indicate that spring compliance can contribute to push-off, but with biomechanical trade-offs that limit the degree to which greater push-off might improve walking economy. © 2011 IEEE

Systematic variation of prosthetic foot spring affects center-of-mass mechanics and metabolic cost during walking

PubMed Central

Zelik, Karl E.; Collins, Steven H.; Adamczyk, Peter G.; Segal, Ava D.; Klute, Glenn K.; Morgenroth, David C.; Hahn, Michael E.; Orendurff, Michael S.; Czerniecki, Joseph M.; Kuo, Arthur D.

2014-01-01

Lower-limb amputees expend more energy to walk than non-amputees and have an elevated risk of secondary disabilities. Insufficient push-off by the prosthetic foot may be a contributing factor. We aimed to systematically study the effect of prosthetic foot mechanics on gait, to gain insight into fundamental prosthetic design principles. We varied a single parameter in isolation, the energy-storing spring in a prototype prosthetic foot, the Controlled Energy Storage and Return (CESR) foot, and observed the effect on gait. Subjects walked on the CESR foot with three different springs. We performed parallel studies on amputees and on non-amputees wearing prosthetic simulators. In both groups, spring characteristics similarly affected ankle and body center-of-mass (COM) mechanics and metabolic cost. Softer springs led to greater energy storage, energy return and prosthetic limb COM push-off work. But metabolic energy expenditure was lowest with a spring of intermediate stiffness, suggesting biomechanical disadvantages to the softest spring despite its greater push-off. Disadvantages of the softest spring may include excessive heel displacements and COM collision losses. We also observed some differences in joint kinetics between amputees and non-amputees walking on the prototype foot. During prosthetic push-off, amputees exhibited reduced energy transfer from the prosthesis to the COM along with increased hip work, perhaps due to greater energy dissipation at the knee. Nevertheless, the results indicate that spring compliance can contribute to push-off, but with biomechanical trade-offs that limit the degree to which greater push-off might improve walking economy. PMID:21708509

Rational Design of Novel Allosteric Dihydrofolate Reductase Inhibitors Showing Antibacterial Effects on Drug-Resistant Escherichia coli Escape Variants.

PubMed

Srinivasan, Bharath; Rodrigues, João V; Tonddast-Navaei, Sam; Shakhnovich, Eugene; Skolnick, Jeffrey

2017-07-21

In drug discovery, systematic variations of substituents on a common scaffold and bioisosteric replacements are often used to generate diversity and obtain molecules with better biological effects. However, this could saturate the small-molecule diversity pool resulting in drug resistance. On the other hand, conventional drug discovery relies on targeting known pockets on protein surfaces leading to drug resistance by mutations of critical pocket residues. Here, we present a two-pronged strategy of designing novel drugs that target unique pockets on a protein's surface to overcome the above problems. Dihydrofolate reductase, DHFR, is a critical enzyme involved in thymidine and purine nucleotide biosynthesis. Several classes of compounds that are structural analogues of the substrate dihydrofolate have been explored for their antifolate activity. Here, we describe 10 novel small-molecule inhibitors of Escherichia coli DHFR, EcDHFR, belonging to the stilbenoid, deoxybenzoin, and chalcone family of compounds discovered by a combination of pocket-based virtual ligand screening and systematic scaffold hopping. These inhibitors show a unique uncompetitive or noncompetitive inhibition mechanism, distinct from those reported for all known inhibitors of DHFR, indicative of binding to a unique pocket distinct from either substrate or cofactor-binding pockets. Furthermore, we demonstrate that rescue mutants of EcDHFR, with reduced affinity to all known classes of DHFR inhibitors, are inhibited at the same concentration as the wild-type. These compounds also exhibit antibacterial activity against E. coli harboring the drug-resistant variant of DHFR. This discovery is the first report on a novel class of inhibitors targeting a unique pocket on EcDHFR.

Systematic Review of Ossicular Chain Anatomy: Strategic Planning for Development of Novel Middle Ear Prostheses.

PubMed

Kamrava, Brandon; Roehm, Pamela C

2017-08-01

Objective To systematically review the anatomy of the ossicular chain. Data Sources Google Scholar, PubMed, and otologic textbooks. Review Methods A systematic literature search was performed on January 26, 2015. Search terms used to discover articles consisted of combinations of 2 keywords. One keyword from both groups was used: [ ossicular, ossicle, malleus, incus, stapes] and [ morphology, morphometric, anatomy, variation, physiology], yielding more than 50,000 hits. Articles were then screened by title and abstract if they did not contain information relevant to human ossicular chain anatomy. In addition to this search, references of selected articles were studied as well as suggested relevant articles from publication databases. Standard otologic textbooks were screened using the search criteria. Results Thirty-three sources were selected for use in this review. From these studies, data on the composition, physiology, morphology, and morphometrics were acquired. In addition, any correlations or lack of correlations between features of the ossicular chain and other features of the ossicular chain or patient were noted, with bilateral symmetry between ossicles being the only important correlation reported. Conclusion There was significant variation in all dimensions of each ossicle between individuals, given that degree of variation, custom fitting, or custom manufacturing of prostheses for each patient could optimize prosthesis fit. From published data, an accurate 3-dimensional model of the malleus, incus, and stapes can be created, which can then be further modified for each patient's individual anatomy.

Global trends in the incidence and prevalence of type 2 diabetes in children and adolescents: a systematic review and evaluation of methodological approaches.

PubMed

Fazeli Farsani, S; van der Aa, M P; van der Vorst, M M J; Knibbe, C A J; de Boer, A

2013-07-01

This study aimed to systematically review what has been reported on the incidence and prevalence of type 2 diabetes in children and adolescents, to scrutinise the methodological issues observed in the included studies and to prepare recommendations for future research and surveillances. PubMed, the Cochrane Database of Systematic Reviews, Scopus, EMBASE and Web of Science were searched from inception to February 2013. Population-based studies on incidence and prevalence of type 2 diabetes in children and adolescents were summarised and methodologically evaluated. Owing to substantial methodological heterogeneity and considerable differences in study populations a quantitative meta-analysis was not performed. Among 145 potentially relevant studies, 37 population-based studies met the inclusion criteria. Variations in the incidence and prevalence rates of type 2 diabetes in children and adolescents were mainly related to age of the study population, calendar time, geographical regions and ethnicity, resulting in a range of 0-330 per 100,000 person-years for incidence rates, and 0-5,300 per 100,000 population for prevalence rates. Furthermore, a substantial variation in the methodological characteristics was observed for response rates (60-96%), ascertainment rates (53-99%), diagnostic tests and criteria used to diagnose type 2 diabetes. Worldwide incidence and prevalence of type 2 diabetes in children and adolescents vary substantially among countries, age categories and ethnic groups and this can be explained by variations in population characteristics and methodological dissimilarities between studies.

Binaural interaction in low-frequency neurons in inferior colliculus of the cat. I. Effects of long interaural delays, intensity, and repetition rate on interaural delay function.

PubMed

Kuwada, S; Yin, T C

1983-10-01

Detailed, quantitative studies were made of the interaural phase sensitivity of 197 neurons with low best frequency in the inferior colliculus (IC) of the barbiturate-anesthetized cat. We analyzed the responses of single cells to interaural delays in which tone bursts were delivered to the two ears via sealed earphones and the onset of the tone to one ear with respect to the other was varied. For most (80%) cells the discharge rate is a cyclic function of interaural delay at a period corresponding to that of the stimulating frequency. The cyclic nature of the interaural delay curve indicates that these cells are sensitive to the interaural phase difference. These cells are distributed throughout the low-frequency zone of the IC, but they are less numerous in the medial and caudal zones. Cells with a wide variety of response patterns will exhibit interaural phase sensitivities at stimulating frequencies up to 3,100 Hz, although above 2,500 Hz the number of such cells decrease markedly. Using dichotic stimuli we could study the cell's sensitivity to the onset delay and interaural phase independently. The large majority of IC cells respond only to changes in interaural phase, with no sensitivity to the onset delay. However, a small number (7%) of cells exhibit a sensitivity to the onset delay as well as to the interaural phase disparity, and most of these cells show an onset response. The effects of changing the stimulus intensity equally to both ears or of changing the interaural intensity difference on the mean interaural phase were studied. While some neurons are not affected by level changes, others exhibit systematic phase shifts for both average and interaural intensity variations, and there is a continuous distribution of sensitivities between these extremes. A few cells also showed systematic changes in the shape of the interaural delay curves as a function of interaural intensity difference, especially at very long delays. These shifts can be interpreted as a form of time-intensity trading. A few cells demonstrated orderly changes in the interaural delay curve as the repetition rate of the stimulus was varied. Some of these changes are consonant with an inhibitory effect that occurs at stimulus offset. The responses of the neurons show a strong bias for stimuli that would originate from he contralateral sound field; 77% of the responses display mean interaural phase angles that are less than 0.5 of a cycle, which are delays to the ipsilateral tone.(ABSTRACT TRUNCATED AT 400 WORDS)

PHASE RELATIONSHIPS OF SOLAR HEMISPHERIC TOROIDAL AND POLOIDAL CYCLES

DOE Office of Scientific and Technical Information (OSTI.GOV)

Muraközy, J., E-mail: murakozy.judit@csfk.mta.hu

2016-08-01

The solar northern and southern hemispheres exhibit differences in their intensities and time profiles of the activity cycles. The time variation of these properties was studied in a previous article covering the data from Cycles 12–23. The hemispheric phase lags exhibited a characteristic variation: the leading role was exchanged between hemispheres every four cycles. The present work extends the investigation of this variation using the data of Staudacher and Schwabe in Cycles 1–4 and 7–10 as well as Spörer’s data in Cycle 11. The previously observed variation cannot be clearly recognized using the data of Staudacher, Schwabe, and Spörer. However,more » it is more interesting that the phase lags of the reversals of the magnetic fields at the poles follow the same variations as those of the hemispheric cycles in Cycles 12–23, i.e., one of the hemispheres leads in four cyles and the leading role jumps to the opposite hemisphere in the next four cycles. This means that this variation is a long-term property of the entire solar dynamo mechanism, for both the toroidal and poloidal fields, which hints at an unidentified component of the process responsible for the long-term memory.« less

Genetic variation in heat-stress tolerance among South American Drosophila populations.

PubMed

Fallis, Lindsey C; Fanara, Juan Jose; Morgan, Theodore J

2011-10-01

Spatial or temporal differences in environmental variables, such as temperature, are ubiquitous in nature and impose stress on organisms. This is especially true for organisms that are isothermal with the environment, such as insects. Understanding the means by which insects respond to temperature and how they will react to novel changes in environmental temperature is important for understanding the adaptive capacity of populations and to predict future trajectories of evolutionary change. The organismal response to heat has been identified as an important environmental variable for insects that can dramatically influence life history characters and geographic range. In the current study we surveyed the amount of variation in heat tolerance among Drosophila melanogaster populations collected at diverse sites along a latitudinal gradient in Argentina (24°-38°S). This is the first study to quantify heat tolerance in South American populations and our work demonstrates that most of the populations surveyed have abundant within-population phenotypic variation, while still exhibiting significant variation among populations. The one exception was the most heat tolerant population that comes from a climate exhibiting the warmest annual mean temperature. All together our results suggest there is abundant genetic variation for heat-tolerance phenotypes within and among natural populations of Drosophila and this variation has likely been shaped by environmental temperature.

Atlas of Variations in Medical Practice in Spain: the Spanish National Health Service under scrutiny.

PubMed

Bernal-Delgado, Enrique; García-Armesto, Sandra; Peiró, Salvador

2014-01-01

Early in the 2000s, a countrywide health services research initiative was launched under the acronym of Atlas VPM: Atlas of Variations in Medical Practice in the Spanish National Health System. This initiative aimed at describing systematic and unwarranted variations in medical practice at geographic level-building upon the seminal experience of the Dartmouth Atlas of Health Care. The paper aims at explaining the Spanish Atlas experience, built upon the pioneer Dartmouth inspiration. A few selected examples will be used along the following sections to illustrate the outlined conceptual framework, the different factors that may affect variation, and some methodological challenges. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

Morphological and genetic divergence in Swedish postglacial stickleback (Pungitius pungitius) populations

PubMed Central

2011-01-01

Background An important objective of evolutionary biology is to understand the processes that govern phenotypic variation in natural populations. We assessed patterns of morphological and genetic divergence among coastal and inland lake populations of nine-spined stickleback in northern Sweden. Coastal populations are either from the Baltic coast (n = 5) or from nearby coastal lakes (n = 3) that became isolated from the Baltic Sea (< 100 years before present, ybp). Inland populations are from freshwater lakes that became isolated from the Baltic approximately 10,000 ybp; either single species lakes without predators (n = 5), or lakes with a recent history of predation (n = 5) from stocking of salmonid predators (~50 ybp). Results Coastal populations showed little variation in 11 morphological traits and had longer spines per unit of body length than inland populations. Inland populations were larger, on average, and showed greater morphological variation than coastal populations. A principal component analysis (PCA) across all populations revealed two major morphological axes related to spine length (PC1, 47.7% variation) and body size (PC2, 32.9% variation). Analysis of PCA scores showed marked similarity in coastal (Baltic coast and coastal lake) populations. PCA scores indicate that inland populations with predators have higher within-group variance in spine length and lower within-group variance in body size than inland populations without predators. Estimates of within-group PST (a proxy for QST) from PCA scores are similar to estimates of FST for coastal lake populations but PST >FST for Baltic coast populations. PST >FST for PC1 and PC2 for inland predator and inland no predator populations, with the exception that PST

Spatial variation in the climatic predictors of species compositional turnover and endemism.

PubMed

Di Virgilio, Giovanni; Laffan, Shawn W; Ebach, Malte C; Chapple, David G

2014-08-01

Previous research focusing on broad-scale or geographically invariant species-environment dependencies suggest that temperature-related variables explain more of the variation in reptile distributions than precipitation. However, species-environment relationships may exhibit considerable spatial variation contingent upon the geographic nuances that vary between locations. Broad-scale, geographically invariant analyses may mask this local variation and their findings may not generalize to different locations at local scales. We assess how reptile-climatic relationships change with varying spatial scale, location, and direction. Since the spatial distributions of diversity and endemism hotspots differ for other species groups, we also assess whether reptile species turnover and endemism hotspots are influenced differently by climatic predictors. Using New Zealand reptiles as an example, the variation in species turnover, endemism and turnover in climatic variables was measured using directional moving window analyses, rotated through 360°. Correlations between the species turnover, endemism and climatic turnover results generated by each rotation of the moving window were analysed using multivariate generalized linear models applied at national, regional, and local scales. At national-scale, temperature turnover consistently exhibited the greatest influence on species turnover and endemism, but model predictive capacity was low (typically r (2) = 0.05, P < 0.001). At regional scales the relative influence of temperature and precipitation turnover varied between regions, although model predictive capacity was also generally low. Climatic turnover was considerably more predictive of species turnover and endemism at local scales (e.g., r (2) = 0.65, P < 0.001). While temperature turnover had the greatest effect in one locale (the northern North Island), there was substantial variation in the relative influence of temperature and precipitation predictors in the remaining four locales. Species turnover and endemism hotspots often occurred in different locations. Climatic predictors had a smaller influence on endemism. Our results caution against assuming that variability in temperature will always be most predictive of reptile biodiversity across different spatial scales, locations and directions. The influence of climatic turnover on the species turnover and endemism of other taxa may exhibit similar patterns of spatial variation. Such intricate variation might be discerned more readily if studies at broad scales are complemented by geographically variant, local-scale analyses.

Directional variance adjustment: bias reduction in covariance matrices based on factor analysis with an application to portfolio optimization.

PubMed

Bartz, Daniel; Hatrick, Kerr; Hesse, Christian W; Müller, Klaus-Robert; Lemm, Steven

2013-01-01

Robust and reliable covariance estimates play a decisive role in financial and many other applications. An important class of estimators is based on factor models. Here, we show by extensive Monte Carlo simulations that covariance matrices derived from the statistical Factor Analysis model exhibit a systematic error, which is similar to the well-known systematic error of the spectrum of the sample covariance matrix. Moreover, we introduce the Directional Variance Adjustment (DVA) algorithm, which diminishes the systematic error. In a thorough empirical study for the US, European, and Hong Kong stock market we show that our proposed method leads to improved portfolio allocation.

Directional Variance Adjustment: Bias Reduction in Covariance Matrices Based on Factor Analysis with an Application to Portfolio Optimization

PubMed Central

Bartz, Daniel; Hatrick, Kerr; Hesse, Christian W.; Müller, Klaus-Robert; Lemm, Steven

2013-01-01

Robust and reliable covariance estimates play a decisive role in financial and many other applications. An important class of estimators is based on factor models. Here, we show by extensive Monte Carlo simulations that covariance matrices derived from the statistical Factor Analysis model exhibit a systematic error, which is similar to the well-known systematic error of the spectrum of the sample covariance matrix. Moreover, we introduce the Directional Variance Adjustment (DVA) algorithm, which diminishes the systematic error. In a thorough empirical study for the US, European, and Hong Kong stock market we show that our proposed method leads to improved portfolio allocation. PMID:23844016

The Sun: Source of the Earth's Energy

NASA Technical Reports Server (NTRS)

Thompson, Barbara J.; Fisher, Richard R. (Technical Monitor)

2001-01-01

The Sun is the primary source of the Earth's energy. However, due to the complexity in the way the energy affects Earth, the various solar sources of the energy, and the variation exhibited by the Sun it is difficult to understand and predict the Earth's response to solar drivers. In addition to visible light the radiant energy of the Sun can exhibit variation in nearly all wavelengths, which can vary over nearly all timescales. Depending on the wavelength of the incident radiation the light can deposit energy in a wide variety or locations and drive processes from below Earth's surface to interplanetary space. Other sources of energy impacting Earth include energetic particles, magnetic fields, and mass and flow variations in the solar wind. Many of these variable energetic processes cannot be coupled and recent results continue to demonstrate that the complex dynamics of the Sun can have a great range of measurable impacts on Earth.

Stochastic and compensatory effects limit persistence of variation in body mass of young caribou

USGS Publications Warehouse

Dale, Bruce W.; Adams, Layne G.; Collins, William B.; Joly, Kyle; Valkenburg, Patrick; Tobey, Robert

2008-01-01

Nutritional restriction during growth can have short- and long-term effects on fitness; however, animals inhabiting uncertain environments may exhibit adaptations to cope with variation in food availability. We examined changes in body mass in free-ranging female caribou (Rangifer tarandus) by measuring mass at birth and at 4, 11, and 16 months of age to evaluate the relative importance of seasonal nutrition to growth, the persistence of cohort-specific variation in body mass through time, and compensatory growth of individuals. Relative mean body mass of cohorts did not persist through time. Compensatory growth of smaller individuals was not observed in summer; however, small calves exhibited more positive change in body mass than did large calves. Compensation occurred during periods of nutritional restriction (winter) rather than during periods of rapid growth (summer) thus differing from the conventional view of compensatory growth.

Huge domain-wall speed variation with respect to ferromagnetic layer thickness in ferromagnetic Pt/Co/TiO2/Pt films

NASA Astrophysics Data System (ADS)

Kim, Dae-Yun; Park, Min-Ho; Park, Yong-Keun; Yu, Ji-Sung; Kim, Joo-Sung; Kim, Duck-Ho; Min, Byoung-Chul; Choe, Sug-Bong

2018-02-01

In this study, we investigate the influence of the ferromagnetic layer thickness on the magnetization process. A series of ultrathin Pt/Co/TiO2/Pt films exhibits domain-wall (DW) speed variation of over 100,000 times even under the same magnetic field, depending on the ferromagnetic layer thickness. From the creep-scaling analysis, such significant variation is found to be mainly attributable to the thickness-dependence of the creep-scaling constant in accordance with the creep-scaling theory of the linear proportionality between the creep-scaling constant and the ferromagnetic layer thickness. Therefore, a thinner film shows a faster DW speed. The DW roughness also exhibits sensitive dependence on the ferromagnetic layer thickness: a thinner film shows smoother DW. The present observation provided a guide for an optimal design rule of the ferromagnetic layer thickness for better performance of DW-based devices.

A constant altitude flight survey method for mapping atmospheric ambient pressures and systematic radar errors

NASA Technical Reports Server (NTRS)

Larson, T. J.; Ehernberger, L. J.

1985-01-01

The flight test technique described uses controlled survey runs to determine horizontal atmospheric pressure variations and systematic altitude errors that result from space positioning measurements. The survey data can be used not only for improved air data calibrations, but also for studies of atmospheric structure and space positioning accuracy performance. The examples presented cover a wide range of radar tracking conditions for both subsonic and supersonic flight to an altitude of 42,000 ft.

Boron Isotopic Composition Correlates with Ultra-Structure in a - Sea Coral Lophelia Pertusa: Implications for Biomineralization and - PH

NASA Astrophysics Data System (ADS)

Blamart, D.; Rollion-Bard, C.; Meibom, A.; Cuif, J.; Juillet-Leclerc, A.; Dauphin, Y.; Douarin, M.

2007-12-01

The geochemistry (stable isotopes and trace elements) of biogenic carbonates has been widely used for more than fifty years to reconstruct past climatic variability. During this time, the studies were mainly based on bulk sampling limiting sometimes the interpretations of the geochemical data as paleoclimatic proxies. Recently, high spatial resolution sampling techniques, such as micro-mill and SIMS, have been employed in the study of C, O and B isotopic compositions and trace elements (Mg, Sr) in the skeletons of a variety of (deep-sea) coral species. These studies have documented dramatic 'vital effects' and uncovered a systematic relationship between skeletal ultra-structure and stable isotopic composition. The formation of skeleton corals follows a universal two-step growth process. At the tips of the skeletal structures, the mineralizing cell layer produces centers of calcification (COC) or, equivalently, Early Mineralization Zone (EMZ). These EMZ are subsequently overgrown by fibrous aragonite(FA) consisting of cyclically added layers. The EMZ are characterized by systematically lighter C and O isotopic compositions compared with the adjacent FA. A number of geochemical models have been proposed, in which this systematic stable isotopic difference between EMZ and FA is ascribed to a biologically induced variation in the pH of a proposed Extra-cytoplasmic Calcifying Fluid (ECF) reservoir. In these models, relatively high pH conditions during the formation of EMZ result in relatively light C and O isotopic compositions compared with FA, which form under generally lower pH conditions. A direct test of such models would be possible if the Boron isotopic composition, which is pH sensitive, of EMZ and FA could be measured. We performed ion microprobe d11B measurements for EMZ and FA in Lophelia pertusa, a deep-sea coral common in the North-East Atlantic Ocean. We observe a systematic difference in B isotopic composition between the EMZ and FA skeleton. In EMZ, the measured δ11B values are consistently low. Fibrous aragonite is characterized by systematically higher d11B values, but also display B isotopic heterogeneity associated with specific growth bands in the calyx wall. The magnitude of the observed B isotopic variations cannot be explained by changes in environmental conditions and are likely caused by biological processes involved in the biomineralization of new skeleton; i.e. 'vital' effects. The observed B isotopic variations are opposite to the predictions of geochemical models for vital effects. Our data indicate that pH variations are not responsible for the observed stable isotopic fractionations. Geochemical models therefore do not provide an adequate framework within which to understand coral skeletal formation. Without a better understanding of these processes, which require experiments, the use of B isotopic composition to reconstruct paleo-pH variations in the oceans must be considered problematic - at least as far as Lophelia pertusa is concerned.

Analysis of all-frequency variational behavior of the Kirchhoff approximation for a classic surface-scattering model

NASA Technical Reports Server (NTRS)

Bird, J. F.

1985-01-01

In testing a stochastic variational principle at high frequencies by using a Kirchhoffean trial function in an idealized model for surface scattering - a randomly embossed plane - we have found not only the predicted high-frequency improvement but also an unexpected low-frequency improvement in the calculated scattering amplitudes. To investigate systematically the all-frequency variational behavior, we consider here the deterministic one-boss case - Rayleigh's classic model whose exact solution is available for comparison - over all wavelengths, polarizations, and configurations of incidence and scattering. We examine analytically in particular the long-wave limit of the variational-Kirchhoff amplitudes; the results demonstrate improvements in both wavelength and angle depedence for horizontal (TM) polarization and some variational improvements for vertical (TE) polarization. This low-frequency behavior in tandem with the foreseen high-frequency improvement leads to good variational-Kirchhoff results through the intermediate resonance-frequency regime for this model.

Systematic trends in photonic reagent induced reactions in a homologous chemical family.

PubMed

Tibbetts, Katharine Moore; Xing, Xi; Rabitz, Herschel

2013-08-29

The growing use of ultrafast laser pulses to induce chemical reactions prompts consideration of these pulses as "photonic reagents" in analogy to chemical reagents. This work explores the prospect that photonic reagents may affect systematic trends in dissociative ionization reactions of a homologous family of halomethanes, much as systematic outcomes are often observed for reactions between homologous families of chemical reagents and chemical substrates. The experiments in this work with photonic reagents of varying pulse energy and linear spectral chirp reveal systematic correlations between observable ion yields and the following set of natural variables describing the substrate molecules: the ionization energy of the parent molecule, the appearance energy of each fragment ion, and the relative strength of carbon-halogen bonds in molecules containing two different halogens. The results suggest that reactions induced by photonic reagents exhibit systematic behavior analogous to that observed in reactions driven by chemical reagents, which provides a basis to consider empirical "rules" for predicting the outcomes of photonic reagent induced reactions.

Morphological and genetic analysis of four color morphs of bean leaf beetle, Cerotoma trifurcata (Coleoptera: Chrysomelidae)

USDA-ARS?s Scientific Manuscript database

Bean leaf beetle (BLB) exhibits a relatively large amount of morphological variation in terms of color but little is known about the underlying genetic structure and gene flow. Genetic variation among four color phenotypes of the BLB was analyzed using amplified fragment length polymorphisms (AFLP) ...

Nuclear genetic variation across the range of ponderosa pine (Pinus ponderosa): Phylogeographic, taxonomic and conservation implications

Treesearch

Kevin M. Potter; Valerie D. Hipkins; Mary F. Mahalovich; Robert E. Means

2015-01-01

Ponderosa pine (Pinus ponderosa) is among the most broadly distributed conifer species of western North America, where it possesses considerable ecological, esthetic, and commercial value. It exhibits complicated patterns of morphological and genetic variation, suggesting that it may be in the process of differentiating into distinct regional...

A cross-cultural approach to the study of the folk illness nervios.

PubMed

Baer, Roberta D; Weller, Susan C; de Alba Garcia, Javier Garcia; Glazer, Mark; Trotter, Robert; Pachter, Lee; Klein, Robert E

2003-09-01

To systematically study and document regional variations in descriptions of nervios, we undertook a multisite comparative study of the illness among Puerto Ricans, Mexicans, Mexican Americans, and Guatemalans. We also conducted a parallel study on susto (Weller et al. 2002, Culture, Medicine and Psychiatry 26(4): 449-472), which allows for a systematic comparison of these illnesses across sites. The focus of this paper is inter- and intracultural variations in descriptions in four Latino populations of the causes, symptoms, and treatments of nervios, as well as similarities and differences between nervios and susto in these same communities. We found agreement among all four samples on a core description of nervios, as well as some overlap in aspects of nervios and susto. However, nervios is a much broader illness, related more to continual stresses. In contrast, susto seems to be related to a single stressful event.

Sequencing of mitochondrial genomes of nine Aspergillus and Penicillium species identifies mobile introns and accessory genes as main sources of genome size variability.

PubMed

Joardar, Vinita; Abrams, Natalie F; Hostetler, Jessica; Paukstelis, Paul J; Pakala, Suchitra; Pakala, Suman B; Zafar, Nikhat; Abolude, Olukemi O; Payne, Gary; Andrianopoulos, Alex; Denning, David W; Nierman, William C

2012-12-12

The genera Aspergillus and Penicillium include some of the most beneficial as well as the most harmful fungal species such as the penicillin-producer Penicillium chrysogenum and the human pathogen Aspergillus fumigatus, respectively. Their mitochondrial genomic sequences may hold vital clues into the mechanisms of their evolution, population genetics, and biology, yet only a handful of these genomes have been fully sequenced and annotated. Here we report the complete sequence and annotation of the mitochondrial genomes of six Aspergillus and three Penicillium species: A. fumigatus, A. clavatus, A. oryzae, A. flavus, Neosartorya fischeri (A. fischerianus), A. terreus, P. chrysogenum, P. marneffei, and Talaromyces stipitatus (P. stipitatum). The accompanying comparative analysis of these and related publicly available mitochondrial genomes reveals wide variation in size (25-36 Kb) among these closely related fungi. The sources of genome expansion include group I introns and accessory genes encoding putative homing endonucleases, DNA and RNA polymerases (presumed to be of plasmid origin) and hypothetical proteins. The two smallest sequenced genomes (A. terreus and P. chrysogenum) do not contain introns in protein-coding genes, whereas the largest genome (T. stipitatus), contains a total of eleven introns. All of the sequenced genomes have a group I intron in the large ribosomal subunit RNA gene, suggesting that this intron is fixed in these species. Subsequent analysis of several A. fumigatus strains showed low intraspecies variation. This study also includes a phylogenetic analysis based on 14 concatenated core mitochondrial proteins. The phylogenetic tree has a different topology from published multilocus trees, highlighting the challenges still facing the Aspergillus systematics. The study expands the genomic resources available to fungal biologists by providing mitochondrial genomes with consistent annotations for future genetic, evolutionary and population studies. Despite the conservation of the core genes, the mitochondrial genomes of Aspergillus and Penicillium species examined here exhibit significant amount of interspecies variation. Most of this variation can be attributed to accessory genes and mobile introns, presumably acquired by horizontal gene transfer of mitochondrial plasmids and intron homing.

The Meristogram: a neglected tool for acanthocephalan systematics

PubMed Central

2016-01-01

Abstract Background The hooks of the acanthocephalan proboscis exhibit serial variation in size and shape. The Meristogram was developed by Huffman and Bullock (1975) to provide a graphical representation of this positional variation in hook morphology. Initial studies demonstrated the ability of the Meristogram to discriminate species within the genera Echinorhynchus and Pomphorhynchus (Huffman and Bullock 1975, Huffman and Nickol 1978, Gleason and Huffman 1981). However, the reliability of the method for taxonomic work was questioned by Shostak et al. (1986) after they found intra-specific variation in two Echinorhynchus species. Uncertainty about the usefulness of the Meristogram and the absence of a readily available software implementation of the algorithm, might explain why this abstract proboscis character has yet to be adopted by acanthocephalan systematists. New information The Meristogram algorithm was implemented in the R language and a simple graphical user interface created to facilitate ease of use (the software is freely available from https://github.com/WaylandM/meristogram). The accuracy of the algorithm's formula for calculating hook cross-sectional area was validated by data collected using a digitizing tablet. Meristograms were created from data in public respositories for eight Echinorhynchus taxa: E. bothniensis, E. 'bothniensis', E. gadi spp. A, B and I, E. brayi, E. salmonis and E. truttae. In this preliminary analysis, the meristogram differentiated E. bothniensis, E. brayi, E. gadi sp. B, E. salmonis and E. truttae from each other, and from the remaining taxa in this study, but independent data will be required for validation. Sample sizes for E. 'bothniensis' and E. gadi spp. A and I were too small to identify diagnostic features with any degree of confidence. Meristogram differences among the sibling species of the E. gadi and E. bothniensis groups suggest that the 'intra-specfic' variation in meristogram previously reported for some Echinorhynchus taxa, may have actually represented morphological divergence between unrecognized cryptic species. Hierarchical clustering of taxa based on Meristogram data yielded dendrograms that were largely concordant with phylogenetic relationships inferred from DNA sequence data, indicating the presence of a strong phylogenetic signal. PMID:26929718

Variation in sperm displacement and its association with accessory gland protein loci in Drosophila melanogaster.

PubMed

Clark, A G; Aguadé, M; Prout, T; Harshman, L G; Langley, C H

1995-01-01

Genes that influence mating and/or fertilization success may be targets for strong natural selection. If females remate frequently relative to the duration of sperm storage and rate of sperm use, sperm displacement may be an important component of male reproductive success. Although it has long been known that mutant laboratory stocks of Drosophila differ in sperm displacement, the magnitude of the naturally occurring genetic variation in this character has not been systematically quantified. Here we report the results of a screen for variation in sperm displacement among 152 lines of Drosophilia melanogaster that were made homozygous for second and/or third chromosomes recovered from natural populations. Sperm displacement was assayed by scoring the progeny of cn;bw females that had been mated sequentially to cn;bw and tested males in either order. Highly significant differences were seen in both the ability to displace sperm that is resident in the female's reproductive tract and in the ability to resist displacement by subsequent sperm. Most lines exhibited nearly complete displacement, having nearly all progeny sired by the second male, but several lines had as few as half the progeny fathered by the second male. Lines that were identified in the screen for naturally occurring variation in sperm displacement were also characterized for single-strand conformation polymorphisms (SSCP) at seven accessory gland protein (Acp) genes, Glucose dehydrogenase (Gld), and Esterase-6 (Est-6). Acp genes encode proteins that are in some cases known to be transmitted to the female in the seminal fluid and are likely candidates for genes that might mediate the phenomenon of sperm displacement. Significant associations were found between particular Acp alleles at four different loci (Acp26Aa/Ab, Acp29B, Acp36DE and Acp53E) and the ability of males to resist displacement by subsequent sperm. There was no correlation between the ability to displace resident sperm and the ability to resist being displaced by subsequent sperm. This lack of correlation, and the association of Acp alleles with resisting subsequent sperm only, suggests that different mechanisms mediate the two components of sperm displacement.

The microgeographical patterns of morphological and molecular variation of a mixed ploidy population in the species complex Actinidia chinensis.

PubMed

Liu, Yifei; Li, Dawei; Yan, Ling; Huang, Hongwen

2015-01-01

Polyploidy and hybridization are thought to have significant impacts on both the evolution and diversification of the genus Actinidia, but the structure and patterns of morphology and molecular diversity relating to ploidy variation of wild Actinidia plants remain much less understood. Here, we examine the distribution of morphological variation and ploidy levels along geographic and environmental variables of a large mixed-ploidy population of the A. chinensis species complex. We then characterize the extent of both genetic and epigenetic diversity and differentiation exhibited between individuals of different ploidy levels. Our results showed that while there are three ploidy levels in this population, hexaploids were constituted the majority (70.3%). Individuals with different ploidy levels were microgeographically structured in relation to elevation and extent of niche disturbance. The morphological characters examined revealed clear difference between diploids and hexaploids, however tetraploids exhibited intermediate forms. Both genetic and epigenetic diversity were high but the differentiation among cytotypes was weak, suggesting extensive gene flow and/or shared ancestral variation occurred in this population even across ploidy levels. Epigenetic variation was clearly correlated with changes in altitudes, a trend of continuous genetic variation and gradual increase of epigenomic heterogeneities of individuals was also observed. Our results show that complex interactions between the locally microgeographical environment, ploidy and gene flow impact A. chinensis genetic and epigenetic variation. We posit that an increase in ploidy does not broaden the species habitat range, but rather permits A. chinensis adaptation to specific niches.

Higher-Order Systematic Effects in the Muon Beam-Spin Dynamics for Muon g-2

NASA Astrophysics Data System (ADS)

Crnkovic, Jason; Brown, Hugh; Krouppa, Brandon; Metodiev, Eric; Morse, William; Semertzidis, Yannis; Tishchenko, Vladimir

2016-03-01

The BNL Muon g-2 Experiment (E821) produced a precision measurement of the muon anomalous magnetic moment, where as the Fermilab Muon g-2 Experiment (E989) is an upgraded version of E821 that has a goal of producing a measurement with approximately 4 times more precision. Improving the precision requires a more detailed understanding of the experimental systematic effects, and so three higher-order systematic effects in the muon beam-spin dynamics have recently been found and estimated for E821. The beamline systematic effect originates from muon production in beamline spectrometers, as well as from muons traversing beamline bending magnets. The kicker systematic effect comes from a combination of the variation in time spent inside the muon storage ring across a muon bunch and the temporal structure of the storage ring kicker waveform. Finally, the detector systematic effect arises from a combination of the energy dependent muon equilibrium orbit in the storage ring, muon decay electron drift time, and decay electron detector acceptance effects. Brookhaven Natl Lab.

Spatial and temporal variations in infrared emissions of the upper atmosphere. 2. 15-μm carbon dioxide emission

NASA Astrophysics Data System (ADS)

Semenov, A. I.; Medvedeva, I. V.; Perminov, V. I.; Zheleznov, Yu. A.

2017-09-01

The results of rocket and satellite measurements of carbon dioxide emissions at a wavelength of 15 μm in the upper atmosphere have been systematized and analyzed. Analytical expressions describing the dependence of the altitude distribution of 15-μm CO2 emission intensity and its variation in the altitude range from 100 to 130 km on the season, latitude, and solar activity have been obtained.

The characteristics of 78 related airfoil sections from tests in the variable-density wind tunnel

NASA Technical Reports Server (NTRS)

Jacobs, Eastman N; Ward, Kenneth E; Pinkerton, Robert M

1933-01-01

An investigation of a large group of related airfoils was made in the NACA variable-density wind tunnel at a large value of the Reynolds number. The tests were made to provide data that may be directly employed for a rational choice of the most suitable airfoil section for a given application. The variation of the aerodynamic characteristics with variations in thickness and mean-line form were systematically studied. (author)

Features and machine learning classification of connected speech samples from patients with autopsy proven Alzheimer's disease with and without additional vascular pathology.

PubMed

Rentoumi, Vassiliki; Raoufian, Ladan; Ahmed, Samrah; de Jager, Celeste A; Garrard, Peter

2014-01-01

Mixed vascular and Alzheimer-type dementia and pure Alzheimer's disease are both associated with changes in spoken language. These changes have, however, seldom been subjected to systematic comparison. In the present study, we analyzed language samples obtained during the course of a longitudinal clinical study from patients in whom one or other pathology was verified at post mortem. The aims of the study were twofold: first, to confirm the presence of differences in language produced by members of the two groups using quantitative methods of evaluation; and secondly to ascertain the most informative sources of variation between the groups. We adopted a computational approach to evaluate digitized transcripts of connected speech along a range of language-related dimensions. We then used machine learning text classification to assign the samples to one of the two pathological groups on the basis of these features. The classifiers' accuracies were tested using simple lexical features, syntactic features, and more complex statistical and information theory characteristics. Maximum accuracy was achieved when word occurrences and frequencies alone were used. Features based on syntactic and lexical complexity yielded lower discrimination scores, but all combinations of features showed significantly better performance than a baseline condition in which every transcript was assigned randomly to one of the two classes. The classification results illustrate the word content specific differences in the spoken language of the two groups. In addition, those with mixed pathology were found to exhibit a marked reduction in lexical variation and complexity compared to their pure AD counterparts.

Reliability of bounce drop jump parameters within elite male rugby players.

PubMed

Costley, Lisa; Wallace, Eric; Johnston, Michael; Kennedy, Rodney

2017-07-25

The aims of the study were to investigate the number of familiarisation sessions required to establish reliability of the bounce drop jump (BDJ) and subsequent reliability once familiarisation is achieved. Seventeen trained male athletes completed 4 BDJs in 4 separate testing sessions. Force-time data from a 20 cm BDJ was obtained using two force plates (ensuring ground contact < 250 ms). Subjects were instructed to 'jump for maximal height and minimal contact time' while the best and average of four jumps were compared. A series of performance variables were assessed in both eccentric and concentric phases including jump height, contact time, flight time, reactive strength index (RSI), peak power, rate of force development (RFD) and actual dropping height (ADH). Reliability was assessed using the intraclass correlation coefficient (ICC) and coefficient of variation (CV) while familiarisation was assessed using a repeated measures analysis of variance (ANOVA). The majority of DJ parameters exhibited excellent reliability with no systematic bias evident, while the average of 4 trials provided greater reliability. With the exception of vertical stiffness (CV: 12.0 %) and RFD (CV: 16.2 %) all variables demonstrated low within subject variation (CV range: 3.1 - 8.9 %). Relative reliability was very poor for ADH, with heights ranging from 14.87 - 29.85 cm. High levels of reliability can be obtained from the BDJ with the exception of vertical stiffness and RFD, however, extreme caution must be taken when comparing DJ results between individuals and squads due to large discrepancies between actual drop height and platform height.

Cardiac Position Sensitivity Study in the Electrocardiographic Forward Problem Using Stochastic Collocation and Boundary Element Methods

PubMed Central

Swenson, Darrell J.; Geneser, Sarah E.; Stinstra, Jeroen G.; Kirby, Robert M.; MacLeod, Rob S.

2012-01-01

The electrocardiogram (ECG) is ubiquitously employed as a diagnostic and monitoring tool for patients experiencing cardiac distress and/or disease. It is widely known that changes in heart position resulting from, for example, posture of the patient (sitting, standing, lying) and respiration significantly affect the body-surface potentials; however, few studies have quantitatively and systematically evaluated the effects of heart displacement on the ECG. The goal of this study was to evaluate the impact of positional changes of the heart on the ECG in the specific clinical setting of myocardial ischemia. To carry out the necessary comprehensive sensitivity analysis, we applied a relatively novel and highly efficient statistical approach, the generalized polynomial chaos-stochastic collocation method, to a boundary element formulation of the electrocardiographic forward problem, and we drove these simulations with measured epicardial potentials from whole-heart experiments. Results of the analysis identified regions on the body-surface where the potentials were especially sensitive to realistic heart motion. The standard deviation (STD) of ST-segment voltage changes caused by the apex of a normal heart, swinging forward and backward or side-to-side was approximately 0.2 mV. Variations were even larger, 0.3 mV, for a heart exhibiting elevated ischemic potentials. These variations could be large enough to mask or to mimic signs of ischemia in the ECG. Our results suggest possible modifications to ECG protocols that could reduce the diagnostic error related to postural changes in patients possibly suffering from myocardial ischemia. PMID:21909818

Surface modification effects of fluorine-doped tin dioxide by oxygen plasma ion implantation

NASA Astrophysics Data System (ADS)

Tang, Peng; Liu, Cai; Zhang, Jingquan; Wu, Lili; Li, Wei; Feng, Lianghuan; Zeng, Guanggen; Wang, Wenwu

2018-04-01

SnO2:F (FTO), as a kind of transparent conductive oxide (TCO), exhibits excellent transmittance and conductivity and is widely used as transparency electrodes in solar cells. It's very important to modifying the surface of FTO for it plays a critical role in CdTe solar cells. In this study, modifying effects of oxygen plasma on FTO was investigated systematically. Oxygen plasma treatment on FTO surface with ion accelerating voltage ranged from 0.4 kV to 1.6 kV has been processed. The O proportion of surface was increased after ion implantation. The Fermi level of surface measurement by XPS valance band spectra was lowered as the ion accelerating voltage increased to 1.2 kV and then raised as accelerating voltage was elevated to 1.6 kV. The work function measured by Kelvin probe force microscopy increased after ion implanting, and it was consistent with the variation of Fermi level. The change of energy band structure of FTO surface mainly originated from the surface composition variation. As FTO conduction was primarily due to oxyanion hole, the carrier was electron and its concentration was reduced while O proportion was elevated at the surface of FTO, as a result, the Fermi level lowered and the work function was enlarged. It was proved that oxygen plasma treatment is an effective method to modulate the energy band structure of the surface as well as other properties of FTO, which provides much more space for interface and surface modification and then photoelectric device performance promotion.

Atmospheric circulations of terrestrial planets orbiting low-mass stars

NASA Astrophysics Data System (ADS)

Edson, Adam; Lee, Sukyoung; Bannon, Peter; Kasting, James F.; Pollard, David

2011-03-01

Circulations and habitable zones of planets orbiting low-mass stars are investigated. Many of these planets are expected to rotate synchronously relative to their parent stars, thereby raising questions about their surface temperature distributions and habitability. We use a global circulation model to study idealized, synchronously rotating (tidally locked) planets of various rotation periods, with surfaces of all land or all water, but with an Earth-like atmosphere and solar insolation. The dry planets exhibit wide variations in surface temperature: >80 °C on the dayside to <-110 °C on the nightside for the 240-h rotator, for example. The water-covered aquaplanets are warmer and exhibit narrower ranges of surface temperatures, e.g., ∼40 °C to >-60 °C for the 240-h orbiter. They also have a larger habitable area, defined here as the region where average surface temperatures are between 0 °C and 50 °C. This concept has little relevance for either dry or aquaplanets, but might become relevant on a planet with both land area and oceans. The circulations on these tidally locked planets exhibit systematic changes as the rotation period is varied. However, they also reveal abrupt transitions between two different circulation regimes and multiple equilibria. For the dry planet, the transition occurs between a 4-day and a 5-day period, while for the aquaplanet, it occurs between a 3-day and a 4-day period. For both dry and aqua planets, this transition occurs when the Rossby deformation radius exceeds half the planetary radius. Further investigation on the dry planet reveals that multiple equilibria exist between 100- and 221-h periods. These multiple equilibria may be relevant for real planets within the habitable zones of late K and M stars, because these planets are expected to have rotation periods between 8 and 100 Earth days.

Variability in home mechanical ventilation prescription.

PubMed

Escarrabill, Joan; Tebé, Cristian; Espallargues, Mireia; Torrente, Elena; Tresserras, Ricard; Argimón, J

2015-10-01

Few studies have analyzed the prevalence and accessibility of home mechanical ventilation (HMV). The aim of this study was to characterize the prevalence of HMV and variability in prescriptions from administrative data. Prescribing rates of HMV in the 37 healthcare sectors of the Catalan Health Service were compared from billing data from 2008 to 2011. Crude accumulated activity rates (per 100,000 population) were calculated using systematic component of variation (SCV) and empirical Bayes (EB) methods. Standardized activity ratios (SAR) were described using a map of healthcare sectors. A crude rate of 23 HMV prescriptions per 100,000 population was observed. Rates increase with age and have increased by 39%. Statistics measuring variation not due to chance show a high variation in women (CSV=0.20 and EB=0.30) and in men (CSV=0.21 and EB=0.40), and were constant over time. In a multilevel Poisson model, hospitals with a chest unit were associated with a greater number of cases (beta=0.68, P<.0001). High variability in prescribing HMV can be explained, in part, by the attitude of professionals towards treatment and accessibility to specialist centers with a chest unit. Analysis of administrative data and variability mapping help identify unexplained variations and, in the absence of systematic records, are a feasible way of tracking treatment. Copyright © 2014 SEPAR. Published by Elsevier Espana. All rights reserved.

Application of indices Cp and Cpk to improve quality control capability in clinical biochemistry laboratories.

PubMed

Chen, Ming-Shu; Wu, Ming-Hsun; Lin, Chih-Ming

2014-04-30

The traditional criteria for acceptability of analytic quality may not be objective in clinical laboratories. To establish quality control procedures intended to enhance Westgard multi-rules for improving the quality of clinical biochemistry tests, we applied the Cp and Cpk quality-control indices to monitor tolerance fitting and systematic variation of clinical biochemistry test results. Daily quality-control data of a large Taiwanese hospital in 2009 were analyzed. The test items were selected based on an Olympus biochemistry machine and included serum albumin, aspartate aminotransferase, cholesterol, glucose and potassium levels. Cp and Cpk values were calculated for normal and abnormal levels, respectively. The tolerance range was estimated with data from 50 laboratories using the same instruments and reagents. The results showed a monthly trend of variation for the five items under investigation. The index values of glucose were lower than those of the other items, and their values were usually <2. In contrast to the Cp value for cholesterol, Cpk of cholesterol was lower than 2, indicating a systematic error that should be further investigated. This finding suggests a degree of variation or failure to meet specifications that should be corrected. The study indicated that Cp and Cpk could be applied not only for monitoring variations in quality control, but also for revealing inter-laboratory qualitycontrol capability differences.

Assessing response of sediment load variation to climate change and human activities with six different approaches.

PubMed

Zhao, Guangju; Mu, Xingmin; Jiao, Juying; Gao, Peng; Sun, Wenyi; Li, Erhui; Wei, Yanhong; Huang, Jiacong

2018-05-23

Understanding the relative contributions of climate change and human activities to variations in sediment load is of great importance for regional soil, and river basin management. Considerable studies have investigated spatial-temporal variation of sediment load within the Loess Plateau; however, contradictory findings exist among methods used. This study systematically reviewed six quantitative methods: simple linear regression, double mass curve, sediment identity factor analysis, dam-sedimentation based method, the Sediment Delivery Distributed (SEDD) model, and the Soil Water Assessment Tool (SWAT) model. The calculation procedures and merits for each method were systematically explained. A case study in the Huangfuchuan watershed on the northern Loess Plateau has been undertaken. The results showed that sediment load had been reduced by 70.5% during the changing period from 1990 to 2012 compared to that of the baseline period from 1955 to 1989. Human activities accounted for an average of 93.6 ± 4.1% of the total decline in sediment load, whereas climate change contributed 6.4 ± 4.1%. Five methods produced similar estimates, but the linear regression yielded relatively different results. The results of this study provide a good reference for assessing the effects of climate change and human activities on sediment load variation by using different methods. Copyright © 2018. Published by Elsevier B.V.

Morphological variation in Homo erectus and the origins of developmental plasticity

PubMed Central

Antón, Susan C.; Taboada, Hannah G.; Middleton, Emily R.; Rainwater, Christopher W.; Taylor, Andrea B.; Turner, Trudy R.; Turnquist, Jean E.; Weinstein, Karen J.; Williams, Scott A.

2016-01-01

Homo erectus was the first hominin to exhibit extensive range expansion. This extraordinary departure from Africa, especially into more temperate climates of Eurasia, has been variously related to technological, energetic and foraging shifts. The temporal and regional anatomical variation in H. erectus suggests that a high level of developmental plasticity, a key factor in the ability of H. sapiens to occupy a variety of habitats, may also have been present in H. erectus. Developmental plasticity, the ability to modify development in response to environmental conditions, results in differences in size, shape and dimorphism across populations that relate in part to levels of resource sufficiency and extrinsic mortality. These differences predict not only regional variations but also overall smaller adult sizes and lower levels of dimorphism in instances of resource scarcity and high predator load. We consider the metric variation in 35 human and non-human primate ‘populations’ from known environmental contexts and 14 time- and space-restricted paleodemes of H. erectus and other fossil Homo. Human and non-human primates exhibit more similar patterns of variation than expected, with plasticity evident, but in differing patterns by sex across populations. The fossil samples show less evidence of variation than expected, although H. erectus varies more than Neandertals. This article is part of the themed issue ‘Major transitions in human evolution’. PMID:27298467

Novel sensing technology in fall risk assessment in older adults: a systematic review.

PubMed

Sun, Ruopeng; Sosnoff, Jacob J

2018-01-16

Falls are a major health problem for older adults with significant physical and psychological consequences. A first step of successful fall prevention is to identify those at risk of falling. Recent advancement in sensing technology offers the possibility of objective, low-cost and easy-to-implement fall risk assessment. The objective of this systematic review is to assess the current state of sensing technology on providing objective fall risk assessment in older adults. A systematic review was conducted in accordance to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis statement (PRISMA). Twenty-two studies out of 855 articles were systematically identified and included in this review. Pertinent methodological features (sensing technique, assessment activities, outcome variables, and fall discrimination/prediction models) were extracted from each article. Four major sensing technologies (inertial sensors, video/depth camera, pressure sensing platform and laser sensing) were reported to provide accurate fall risk diagnostic in older adults. Steady state walking, static/dynamic balance, and functional mobility were used as the assessment activity. A diverse range of diagnostic accuracy across studies (47.9% - 100%) were reported, due to variation in measured kinematic/kinetic parameters and modelling techniques. A wide range of sensor technologies have been utilized in fall risk assessment in older adults. Overall, these devices have the potential to provide an accurate, inexpensive, and easy-to-implement fall risk assessment. However, the variation in measured parameters, assessment tools, sensor sites, movement tasks, and modelling techniques, precludes a firm conclusion on their ability to predict future falls. Future work is needed to determine a clinical meaningful and easy to interpret fall risk diagnosis utilizing sensing technology. Additionally, the gap between functional evaluation and user experience to technology should be addressed.

A test for correction made to spin systematics for coupled band in doubly-odd nuclei

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kumar, Vinod, E-mail: vinod2.k2@gmail.com

2015-12-15

Systematic Spin Assignments were generally made by using the argument that the energy of levels is a function of neutron number. In the present systematics, the excitation energy of the levels incorporated the effect of nuclear deformation and signature splitting. The nuclear deformation changes toward the mid-shell, therefore a smooth variation in the excitation energy of the levels is observed towards the mid-shell, that intended to make systematics as a function of neutron number towards the mid-shell. Another term “signature splitting” that push the energy of levels for odd- and even-spin sequences up and down, caused the different energy variationmore » pattern for odd- and even-spin sequences. The corrections made in the spin systematics were tested for the known spins of various isotopic chain. In addition, the inconsistency in spin assignments made by the spin systematics and other methods of the configuration πh{sub 11/2} ⊗ νh{sub 11/2} band belonging to {sup 112,114,116}Cs, {sup 126}Pr, and {sup 138}Pr, as an example, was resolved by the correctionmade in the present spin systematics.« less

Systematic Regional Variations in Purkinje Cell Spiking Patterns

PubMed Central

Xiao, Jianqiang; Cerminara, Nadia L.; Kotsurovskyy, Yuriy; Aoki, Hanako; Burroughs, Amelia; Wise, Andrew K.; Luo, Yuanjun; Marshall, Sarah P.; Sugihara, Izumi; Apps, Richard; Lang, Eric J.

2014-01-01

In contrast to the uniform anatomy of the cerebellar cortex, molecular and physiological studies indicate that significant differences exist between cortical regions, suggesting that the spiking activity of Purkinje cells (PCs) in different regions could also show distinct characteristics. To investigate this possibility we obtained extracellular recordings from PCs in different zebrin bands in crus IIa and vermis lobules VIII and IX in anesthetized rats in order to compare PC firing characteristics between zebrin positive (Z+) and negative (Z−) bands. In addition, we analyzed recordings from PCs in the A2 and C1 zones of several lobules in the posterior lobe, which largely contain Z+ and Z− PCs, respectively. In both datasets significant differences in simple spike (SS) activity were observed between cortical regions. Specifically, Z− and C1 PCs had higher SS firing rates than Z+ and A2 PCs, respectively. The irregularity of SS firing (as assessed by measures of interspike interval distribution) was greater in Z+ bands in both absolute and relative terms. The results regarding systematic variations in complex spike (CS) activity were less consistent, suggesting that while real differences can exist, they may be sensitive to other factors than the cortical location of the PC. However, differences in the interactions between SSs and CSs, including the post-CS pause in SSs and post-pause modulation of SSs, were also consistently observed between bands. Similar, though less strong trends were observed in the zonal recordings. These systematic variations in spontaneous firing characteristics of PCs between zebrin bands in vivo, raises the possibility that fundamental differences in information encoding exist between cerebellar cortical regions. PMID:25144311

Management of Subtle Cognitive Communication Deficits.

ERIC Educational Resources Information Center

Milton, Sandra B.

1988-01-01

Traumatically head-injured individuals who reach the higher stages of recovery typically exhibit cognitive communication disorders. Patient management requires, among other considerations, a focus on functional communication competency, an ecologic-systematic perspective, and use of compensatory techniques. A case study applies this management…

Why Can You "Have a Drink" When You Can't "*Have an Eat?"

ERIC Educational Resources Information Center

Wierzbicka, Anna

1982-01-01

Argues that sentences in the "have a V" frame are not idiosyncratic, but exhibit orderly and systematic behavior and are governed by strict semantic rules. Discusses 10 subtypes, each with a slightly different semantic formula. (EKN)

Amplitude Variations in Pulsating Red Giants. II. Some Systematics

NASA Astrophysics Data System (ADS)

Percy, J. R.; Laing, J.

2017-12-01

In order to extend our previous studies of the unexplained phenomenon of cyclic amplitude variations in pulsating red giants, we have used the AAVSO time-series analysis package vstar to analyze long-term AAVSO visual observations of 50 such stars, mostly Mira stars. The relative amount of the variation, typically a factor of 1.5, and the time scale of the variation, typically 20-35 pulsation periods, are not significantly different in longer-period, shorter-period, and carbon stars in our sample, and they also occur in stars whose period is changing secularly, perhaps due to a thermal pulse. The time scale of the variations is similar to that in smaller-amplitude SR variables, but the relative amount of the variation appears to be larger in smaller-amplitude stars, and is therefore more conspicuous. The cause of the amplitude variations remains unclear, though they may be due to rotational modulation of a star whose pulsating surface is dominated by the effects of large convective cells.

When intensions do not map onto extensions: Individual differences in conceptualization.

PubMed

Hampton, James A; Passanisi, Alessia

2016-04-01

Concepts are represented in the mind through knowledge of their extensions (the class of items to which the concept applies) and intensions (features that distinguish that class of items). A common assumption among theories of concepts is that the 2 aspects are intimately related. Hence if there is systematic individual variation in concept representation, the variation should correlate between extensional and intensional measures. A pair of individuals with similar extensional beliefs about a given concept should also share similar intensional beliefs. To test this notion, exemplars (extensions) and features (intensions) of common categories were rated for typicality and importance respectively across 2 occasions. Within-subject consistency was greater than between-subjects consensus on each task, providing evidence for systematic individual variation. Furthermore, the similarity structure between individuals for each task was stable across occasions. However, across 5 samples, similarity between individuals for extensional judgments did not map onto similarity between individuals for intensional judgments. The results challenge the assumption common to many theories of conceptual representation that intensions determine extensions and support a hybrid view of concepts where there is a disconnection between the conceptual resources that are used for the 2 tasks. (c) 2016 APA, all rights reserved).

Finding Planets in K2: A New Method of Cleaning the Data

NASA Astrophysics Data System (ADS)

Currie, Miles; Mullally, Fergal; Thompson, Susan E.

2017-01-01

We present a new method of removing systematic flux variations from K2 light curves by employing a pixel-level principal component analysis (PCA). This method decomposes the light curves into its principal components (eigenvectors), each with an associated eigenvalue, the value of which is correlated to how much influence the basis vector has on the shape of the light curve. This method assumes that the most influential basis vectors will correspond to the unwanted systematic variations in the light curve produced by K2’s constant motion. We correct the raw light curve by automatically fitting and removing the strongest principal components. The strongest principal components generally correspond to the flux variations that result from the motion of the star in the field of view. Our primary method of calculating the strongest principal components to correct for in the raw light curve estimates the noise by measuring the scatter in the light curve after using an algorithm for Savitsy-Golay detrending, which computes the combined photometric precision value (SG-CDPP value) used in classic Kepler. We calculate this value after correcting the raw light curve for each element in a list of cumulative sums of principal components so that we have as many noise estimate values as there are principal components. We then take the derivative of the list of SG-CDPP values and take the number of principal components that correlates to the point at which the derivative effectively goes to zero. This is the optimal number of principal components to exclude from the refitting of the light curve. We find that a pixel-level PCA is sufficient for cleaning unwanted systematic and natural noise from K2’s light curves. We present preliminary results and a basic comparison to other methods of reducing the noise from the flux variations.

Diurnal and Seasonal Variations of Thermal Stratification and Vertical Mixing in a Shallow Fresh Water Lake

NASA Astrophysics Data System (ADS)

Yang, Yichen; Wang, Yongwei; Zhang, Zhen; Wang, Wei; Ren, Xia; Gao, Yaqi; Liu, Shoudong; Lee, Xuhui

2018-04-01

Among several influential factors, the geographical position and depth of a lake determine its thermal structure. In temperate zones, shallow lakes show significant differences in thermal stratification compared to deep lakes. Here, the variation in thermal stratification in Lake Taihu, a shallow fresh water lake, is studied systematically. Lake Taihu is a warm polymictic lake whose thermal stratification varies in short cycles of one day to a few days. The thermal stratification in Lake Taihu has shallow depths in the upper region and a large amplitude in the temperature gradient, the maximum of which exceeds 5°C m-1. The water temperature in the entire layer changes in a relatively consistent manner. Therefore, compared to a deep lake at similar latitude, the thermal stratification in Lake Taihu exhibits small seasonal differences, but the wide variation in the short term becomes important. Shallow polymictic lakes share the characteristic of diurnal mixing. Prominent differences on the duration and frequency of long-lasting thermal stratification are found in these lakes, which may result from the differences of local climate, lake depth, and fetch. A prominent response of thermal stratification to weather conditions is found, being controlled by the stratifying effect of solar radiation and the mixing effect of wind disturbance. Other than the diurnal stratification and convection, the representative responses of thermal stratification to these two factors with contrary effects are also discussed. When solar radiation increases, stronger wind is required to prevent the lake from becoming stratified. A daily average wind speed greater than 6 m s-1 can maintain the mixed state in Lake Taihu. Moreover, wind-induced convection is detected during thermal stratification. Due to lack of solar radiation, convection occurs more easily in nighttime than in daytime. Convection occurs frequently in fall and winter, whereas long-lasting and stable stratification causes less convection in summer.

Benchmarking health system performance across districts in Zambia: a systematic analysis of levels and trends in key maternal and child health interventions from 1990 to 2010.

PubMed

Colson, Katherine Ellicott; Dwyer-Lindgren, Laura; Achoki, Tom; Fullman, Nancy; Schneider, Matthew; Mulenga, Peter; Hangoma, Peter; Ng, Marie; Masiye, Felix; Gakidou, Emmanuela

2015-04-02

Achieving universal health coverage and reducing health inequalities are primary goals for an increasing number of health systems worldwide. Timely and accurate measurements of levels and trends in key health indicators at local levels are crucial to assess progress and identify drivers of success and areas that may be lagging behind. We generated estimates of 17 key maternal and child health indicators for Zambia's 72 districts from 1990 to 2010 using surveys, censuses, and administrative data. We used a three-step statistical model involving spatial-temporal smoothing and Gaussian process regression. We generated estimates at the national level for each indicator by calculating the population-weighted mean of the district values and calculated composite coverage as the average of 10 priority interventions. National estimates masked substantial variation across districts in the levels and trends of all indicators. Overall, composite coverage increased from 46% in 1990 to 73% in 2010, and most of this gain was attributable to the scale-up of malaria control interventions, pentavalent immunization, and exclusive breastfeeding. The scale-up of these interventions was relatively equitable across districts. In contrast, progress in routine services, including polio immunization, antenatal care, and skilled birth attendance, stagnated or declined and exhibited large disparities across districts. The absolute difference in composite coverage between the highest-performing and lowest-performing districts declined from 37 to 26 percentage points between 1990 and 2010, although considerable variation in composite coverage across districts persisted. Zambia has made marked progress in delivering maternal and child health interventions between 1990 and 2010; nevertheless, substantial variations across districts and interventions remained. Subnational benchmarking is important to identify these disparities, allowing policymakers to prioritize areas of greatest need. Analyses such as this one should be conducted regularly and feed directly into policy decisions in order to increase accountability at the local, regional, and national levels.

Overview of systematic reviews of therapeutic ranges: methodologies and recommendations for practice.

PubMed

Cooney, Lewis; Loke, Yoon K; Golder, Su; Kirkham, Jamie; Jorgensen, Andrea; Sinha, Ian; Hawcutt, Daniel

2017-06-02

Many medicines are dosed to achieve a particular therapeutic range, and monitored using therapeutic drug monitoring (TDM). The evidence base for a therapeutic range can be evaluated using systematic reviews, to ensure it continues to reflect current indications, doses, routes and formulations, as well as updated adverse effect data. There is no consensus on the optimal methodology for systematic reviews of therapeutic ranges. An overview of systematic reviews of therapeutic ranges was undertaken. The following databases were used: Cochrane Database of Systematic Reviews (CDSR), Database of Abstracts and Reviews of Effects (DARE) and MEDLINE. The published methodologies used when systematically reviewing the therapeutic range of a drug were analyzed. Step by step recommendations to optimize such systematic reviews are proposed. Ten systematic reviews that investigated the correlation between serum concentrations and clinical outcomes encompassing a variety of medicines and indications were assessed. There were significant variations in the methodologies used (including the search terms used, data extraction methods, assessment of bias, and statistical analyses undertaken). Therapeutic ranges should be population and indication specific and based on clinically relevant outcomes. Recommendations for future systematic reviews based on these findings have been developed. Evidence based therapeutic ranges have the potential to improve TDM practice. Current systematic reviews investigating therapeutic ranges have highly variable methodologies and there is no consensus of best practice when undertaking systematic reviews in this field. These recommendations meet a need not addressed by standard protocols.

Extended molecular phylogenetics and revised systematics of Malagasy scincine lizards.

PubMed

Erens, Jesse; Miralles, Aurélien; Glaw, Frank; Chatrou, Lars W; Vences, Miguel

2017-02-01

Among the endemic biota of Madagascar, skinks are a diverse radiation of lizards that exhibit a striking ecomorphological variation, and could provide an interesting system to study body-form evolution in squamate reptiles. We provide a new phylogenetic hypothesis for Malagasy skinks of the subfamily Scincinae based on an extended molecular dataset comprising 8060bp from three mitochondrial and nine nuclear loci. Our analysis also increases taxon sampling of the genus Amphiglossus by including 16 out of 25 nominal species. Additionally, we examined whether the molecular phylogenetic patterns coincide with morphological differentiation in the species currently assigned to this genus. Various methods of inference recover a mostly strongly supported phylogeny with three main clades of Amphiglossus. However, relationships among these three clades and the limb-reduced genera Grandidierina, Voeltzkowia and Pygomeles remain uncertain. Supported by a variety of morphological differences (predominantly related to the degree of body elongation), but considering the remaining phylogenetic uncertainty, we propose a redefinition of Amphiglossus into three different genera (Amphiglossus sensu stricto, Flexiseps new genus, and Brachyseps new genus) to remove the non-monophyly of Amphiglossus sensu lato and to facilitate future studies on this fascinating group of lizards. Copyright © 2016 Elsevier Inc. All rights reserved.

Selectivity of photoelectrochemical CO2 reduction modulated with electron transfer from size-tunable quantized energy states of CdSe nanocrystals

NASA Astrophysics Data System (ADS)

Cho, Hyunjin; Kim, Whi Dong; Lee, Kangha; Lee, Seokwon; Kang, Gil-Seong; Joh, Han-Ik; Lee, Doh C.

2018-01-01

We investigate the product selectivity of CO2 reduction using NiO photocathodes decorated with CdSe quantum dots (QDs) of varying size in a photoelectrochemical (PEC) cell. Size-tunable and quantized energy states of conduction band in CdSe QDs enable systematic control of electron transfer kinetics from CdSe QDs to NiO. It turns out that different size of CdSe QDs results in variation in product selectivity for CO2 reduction. The energy gap between conduction band edge and redox potential of each reduction product (e.g., CO and CH4) correlates with their production rate. The size dependence of the electron transfer rate estimated from the energy gap is in agreement with the selectivity of CO2 reduction products for all reduction products but CO. The deviation in the case of CO is attributed to sequential conversion of CO into CH4 with CO adsorbed on electrode surface. Based on a premise that the CdSe QDs would exhibit similar surface configuration regardless of QD size, it is concluded that the electron transfer kinetics proves to alter the selectivity of CO2 reduction.

Multi-level storage and ultra-high speed of superlattice-like Ge50Te50/Ge8Sb92 thin film for phase-change memory application.

PubMed

Wu, Weihua; Chen, Shiyu; Zhai, Jiwei; Liu, Xinyi; Lai, Tianshu; Song, Sannian; Song, Zhitang

2017-10-06

Superlattice-like Ge 50 Te 50 /Ge 8 Sb 92 (SLL GT/GS) thin film was systematically investigated for multi-level storage and ultra-fast switching phase-change memory application. In situ resistance measurement indicates that SLL GT/GS thin film exhibits two distinct resistance steps with elevated temperature. The thermal stability of the amorphous state and intermediate state were evaluated with the Kissinger and Arrhenius plots. The phase-structure evolution revealed that the amorphous SLL GT/GS thin film crystallized into rhombohedral Sb phase first, then the rhombohedral GeTe phase. The microstructure, layered structure, and interface stability of SLL GT/GS thin film was confirmed by using transmission electron microscopy. The transition speed of crystallization and amorphization was measured by the picosecond laser pump-probe system. The volume variation during the crystallization was obtained from x-ray reflectivity. Phase-change memory (PCM) cells based on SLL GT/GS thin film were fabricated to verify the multi-level switching under an electrical pulse as short as 30 ns. These results illustrate that the SLL GT/GS thin film has great potentiality in high-density and high-speed PCM applications.

EXPERIMENTAL MEASUREMENT AND INTERPRETATION OF VOLT-AMPERE CURVES

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gingrich, J.E.; Warner, C.; Weeks, C.C.

1962-07-01

Cylindrical and parallel-plane cesium vapor thermionic converters were used for obtaining volt-ampere curves for systematic variations of emitter, collector, and cesium reservoir temperatures, with electrode spacings ranging from a few to many mean free paths, and with space charge conditions varying from electron-rich to ion-rich. The resulting curves exhibit much variety. The saturation currents agree well with the data of Houston and Aamodt for the space charge neutralized, few-mean-free-path cases. Apparent'' saturation currents for space charge limited cases were observed and were always less than the currents predicted by Houston and Aamodt. Several discontinuities in slope were observed in themore » reverse current portion of the curves and these have tentatively been identified with volume ionization of atoms in both the ground and excited states. Similar processes may be important for obtaining the ignited mode. The methods used to measure static and dynamic volt-ampere curves are described. The use of a controlled-current load has yielded a negative resistance'' region in the curves which show the ignited mode. The curves obtained with poor current control do not show this phenomenon. Extinction is considered from the standpoint of Kaufmann' s criterion for stability. (auth)« less

DOE Office of Scientific and Technical Information (OSTI.GOV)

Levin, E. M.; Iowa State Univ., Ames, IA; Cui, J. -F.

125Te NMR spectra and spin-lattice relaxation times, T 1, have been measured for several GeTe-based materials with Te excess. In this paper, the spectra show inhomogeneous broadening by several thousand ppm and a systematic variation in T 1 relaxation time with resonance frequency. The quadratic dependence of the spin-lattice relaxation rate, 1/T 1, on the Knight shift in the Korringa relation is found to be valid over a wide range of Knight shifts. This result confirms that T 1 relaxation in GeTe-based materials is mostly dominated by hyperfine interaction between nuclei and free charge carriers. In GeTe with 2.5% excessmore » of Te, about 15% of the material exhibits a Knight shift of ≥4500 ppm and a T 1 of only 0.3 ms, indicating a high hole concentration that could correspond to close to 50% vacancies on the Ge sublattice in this component. Lastly, our findings provide a basis for determining the charge carrier concentration and its distribution in complex thermoelectric and phase-change tellurides, which should lead to a better understanding of electronic and thermal transport properties as well as chemical bonding in these materials.« less

Quasi-periodic accretion and gravitational waves from oscillating `toroidal neutron stars' around a Schwarzschild black hole

NASA Astrophysics Data System (ADS)

Zanotti, Olindo; Rezzolla, Luciano; Font, José A.

2003-05-01

We present general relativistic hydrodynamics simulations of constant specific angular momentum tori orbiting a Schwarzschild black hole. These tori are expected to form as a result of stellar gravitational collapse, binary neutron star merger or disruption, can reach very high rest-mass densities and behave effectively as neutron stars but with a toroidal topology (i.e. `toroidal neutron stars'). Here our attention is focused on the dynamical response of these objects to axisymmetric perturbations. We show that upon the introduction of perturbations, these systems either become unstable to the runaway instability or exhibit a regular oscillatory behaviour, resulting in a quasi-periodic variation of the accretion rate as well as of the mass quadrupole. The latter, in particular, is responsible for the emission of intense gravitational radiation for which the signal-to-noise ratio at the detector is comparable to or larger than the typical one expected in stellar-core collapse, making these new sources of gravitational waves potentially detectable. We discuss a systematic investigation of the parameter space in both the linear and non-linear regimes, providing estimates of how the gravitational radiation emitted depends on the mass of the torus and on the strength of the perturbation.

The VMC Survey. XI. Radial Stellar Population Gradients in the Galactic Globular Cluster 47 Tucanae

NASA Astrophysics Data System (ADS)

Li, Chengyuan; de Grijs, Richard; Deng, Licai; Rubele, Stefano; Wang, Chuchu; Bekki, Kenji; Cioni, Maria-Rosa L.; Clementini, Gisella; Emerson, Jim; For, Bi-Qing; Girardi, Leo; Groenewegen, Martin A. T.; Guandalini, Roald; Gullieuszik, Marco; Marconi, Marcella; Piatti, Andrés E.; Ripepi, Vincenzo; van Loon, Jacco Th.

2014-07-01

We present a deep near-infrared color-magnitude diagram of the Galactic globular cluster 47 Tucanae, obtained with the Visible and Infrared Survey Telescope for Astronomy (VISTA) as part of the VISTA near-infrared Y, J, K s survey of the Magellanic System (VMC). The cluster stars comprising both the subgiant and red giant branches exhibit apparent, continuous variations in color-magnitude space as a function of radius. Subgiant branch stars at larger radii are systematically brighter than their counterparts closer to the cluster core; similarly, red-giant-branch stars in the cluster's periphery are bluer than their more centrally located cousins. The observations can very well be described by adopting an age spread of ~0.5 Gyr as well as radial gradients in both the cluster's helium abundance (Y) and metallicity (Z), which change gradually from (Y = 0.28, Z = 0.005) in the cluster core to (Y = 0.25, Z = 0.003) in its periphery. We conclude that the cluster's inner regions host a significant fraction of second-generation stars, which decreases with increasing radius; the stellar population in the 47 Tuc periphery is well approximated by a simple stellar population.

Radial Stellar Population Gradients in the Galactic Globular Cluster 47 Tucanae

NASA Astrophysics Data System (ADS)

de Grijs, Richard; Li, Chengyuan; Deng, Licai

2015-01-01

We present a deep near-infrared color-magnitude diagram of the Galactic globular cluster 47 Tucanae, obtained with the Visible and Infrared Survey Telescope for Astronomy (VISTA) as part of the VISTA near-infrared Y, J, Ks survey of the Magellanic System (VMC). The cluster stars comprising both the subgiant and red-giant branches exhibit apparent, continuous variations in color-magnitude space as a function of radius. Subgiant-branch stars at larger radii are systematically brighter than their counterparts closer to the cluster core; similarly, red-giant-branch stars in the cluster's periphery are bluer than their more centrally located cousins. The observations can very well be described by adopting an age spread of ~0.5 Gyr as well as radial gradients in both the cluster's helium abundance (Y) and metallicity (Z), which change gradually from Y = 0.28, Z = 0.005 in the cluster core to Y = 0.25, Z = 0.003 in its periphery. We conclude that the cluster's inner regions host a significant fraction of second-generation stars, which decreases with increasing radius; the stellar population in the 47 Tuc periphery is well approximated by a simple stellar population.

Quantitative and qualitative measure of intralaboratory two-dimensional protein gel reproducibility and the effects of sample preparation, sample load, and image analysis.

PubMed

Choe, Leila H; Lee, Kelvin H

2003-10-01

We investigate one approach to assess the quantitative variability in two-dimensional gel electrophoresis (2-DE) separations based on gel-to-gel variability, sample preparation variability, sample load differences, and the effect of automation on image analysis. We observe that 95% of spots present in three out of four replicate gels exhibit less than a 0.52 coefficient of variation (CV) in fluorescent stain intensity (% volume) for a single sample run on multiple gels. When four parallel sample preparations are performed, this value increases to 0.57. We do not observe any significant change in quantitative value for an increase or decrease in sample load of 30% when using appropriate image analysis variables. Increasing use of automation, while necessary in modern 2-DE experiments, does change the observed level of quantitative and qualitative variability among replicate gels. The number of spots that change qualitatively for a single sample run in parallel varies from a CV = 0.03 for fully manual analysis to CV = 0.20 for a fully automated analysis. We present a systematic method by which a single laboratory can measure gel-to-gel variability using only three gel runs.

Lower tropospheric ozone and aerosol measurements at a coastal mountain site in Northern California

NASA Astrophysics Data System (ADS)

Post, A.; Conley, S. A.; Zhao, Y.; Cliff, S. S.; Faloona, I. C.; Wexler, A. S.; Lighthall, D.

2012-12-01

Increasing concern over the impacts of exogenous air pollution in California's Central Valley have prompted the establishment of a coastal, high altitude monitoring site at the Chews Ridge Observatory (1550 m) approximately 30 km east of Point Sur in Monterey County. Six months of ozone and aerosol measurements are presented in the context of long-range transport and its potential impact on surface air quality in the southern San Joaquin Valley. Moreover, approximately monthly ozone surveys are conducted by aircraft upwind, over the Pacific Ocean, and downwind, over the Central Valley, to characterize horizontal and vertical transport across the coastal mountains. The measurements exhibit no systematic diurnal variations of ozone or water vapor, an indication that the site primarily samples lower free tropospheric air which has not been significantly influenced by either local emissions or convective coupling to the surface. Aerosol size is measured with a scanning mobility particle sizer and composition is analyzed with an 8-stage rotating drum impactor whose substrates are characterized by X-ray fluorescence. Various elemental ratios and back trajectory calculations are used to infer the temporal patterns of influence that long range transport has on California air quality.

Phylogeographic and population genetic analyses reveal multiple species of Boa and independent origins of insular dwarfism.

PubMed

Card, Daren C; Schield, Drew R; Adams, Richard H; Corbin, Andrew B; Perry, Blair W; Andrew, Audra L; Pasquesi, Giulia I M; Smith, Eric N; Jezkova, Tereza; Boback, Scott M; Booth, Warren; Castoe, Todd A

2016-09-01

Boa is a Neotropical genus of snakes historically recognized as monotypic despite its expansive distribution. The distinct morphological traits and color patterns exhibited by these snakes, together with the wide diversity of ecosystems they inhabit, collectively suggest that the genus may represent multiple species. Morphological variation within Boa also includes instances of dwarfism observed in multiple offshore island populations. Despite this substantial diversity, the systematics of the genus Boa has received little attention until very recently. In this study we examined the genetic structure and phylogenetic relationships of Boa populations using mitochondrial sequences and genome-wide SNP data obtained from RADseq. We analyzed these data at multiple geographic scales using a combination of phylogenetic inference (including coalescent-based species delimitation) and population genetic analyses. We identified extensive population structure across the range of the genus Boa and multiple lines of evidence for three widely-distributed clades roughly corresponding with the three primary land masses of the Western Hemisphere. We also find both mitochondrial and nuclear support for independent origins and parallel evolution of dwarfism on offshore island clusters in Belize and Cayos Cochinos Menor, Honduras. Copyright © 2016 Elsevier Inc. All rights reserved.

Systematic variation in the depths of slabs beneath arc volcanoes

USGS Publications Warehouse

England, P.; Engdahl, R.; Thatcher, W.

2004-01-01

The depths to the tops of the zones of intermediate-depth seismicity beneath arc volcanoes are determined using the hypocentral locations of Engdahl et al. These depths are constant, to within a few kilometres, within individual arc segments, but differ by tens of kilometres from one arc segment to another. The range in depths is from 65 km to 130 km, inconsistent with the common belief that the volcanoes directly overlie the places where the slabs reach a critical depth that is roughly constant for all arcs. The depth to the top of the intermediate-depth seismicity beneath volcanoes correlates neither with age of the descending ocean floor nor with the thermal parameter of the slab. This depth does, however, exhibit an inverse correlation with the descent speed of the subducting plate, which is the controlling factor both for the thermal structure of the wedge of mantle above the slab and for the temperature at the top of the slab. We interpret this result as indicating that the location of arc volcanoes is controlled by a process that depends critically upon the temperature at the top of the slab, or in the wedge of mantle, immediately below the volcanic arc.

Experimental saltwater intrusion in coastal aquifers using automated image analysis: Applications to homogeneous aquifers

NASA Astrophysics Data System (ADS)

Robinson, G.; Ahmed, Ashraf A.; Hamill, G. A.

2016-07-01

This paper presents the applications of a novel methodology to quantify saltwater intrusion parameters in laboratory-scale experiments. The methodology uses an automated image analysis procedure, minimising manual inputs and the subsequent systematic errors that can be introduced. This allowed the quantification of the width of the mixing zone which is difficult to measure in experimental methods that are based on visual observations. Glass beads of different grain sizes were tested for both steady-state and transient conditions. The transient results showed good correlation between experimental and numerical intrusion rates. The experimental intrusion rates revealed that the saltwater wedge reached a steady state condition sooner while receding than advancing. The hydrodynamics of the experimental mixing zone exhibited similar traits; a greater increase in the width of the mixing zone was observed in the receding saltwater wedge, which indicates faster fluid velocities and higher dispersion. The angle of intrusion analysis revealed the formation of a volume of diluted saltwater at the toe position when the saltwater wedge is prompted to recede. In addition, results of different physical repeats of the experiment produced an average coefficient of variation less than 0.18 of the measured toe length and width of the mixing zone.

Syllable-related breathing in infants in the second year of life.

PubMed

Parham, Douglas F; Buder, Eugene H; Oller, D Kimbrough; Boliek, Carol A

2011-08-01

This study explored whether breathing behaviors of infants within the 2nd year of life differ between tidal breathing and breathing supporting single unarticulated syllables and canonical/articulated syllables. Vocalizations and breathing kinematics of 9 infants between 53 and 90 weeks of age were recorded. A strict selection protocol was used to identify analyzable breath cycles. Syllables were categorized on the basis of consensus coding. Inspiratory and expiratory durations, excursions, and slopes were calculated for the 3 breath cycle types and were normalized using mean tidal breath measures. Tidal breathing cycles were significantly different from syllable-related cycles on all breathing measures. There were no significant differences between unarticulated syllable cycles and canonical syllable cycles, even after controlling for utterance duration and sound pressure level. Infants in the 2nd year of life exhibit clear differences between tidal breathing and speech-related breathing, but categorically distinct breath support for syllable types with varying articulatory demands was not evident in the present findings. Speech development introduces increasingly complex utterances, so older infants may produce detectable articulation-related adaptations of breathing kinematics. For younger infants, breath support may vary systematically among utterance types, due more to phonatory variations than to articulatory demands.

Syllable-Related Breathing in Infants in the Second Year of Life

PubMed Central

Parham, Douglas F.; Buder, Eugene H.; Oller, D. Kimbrough; Boliek, Carol A.

2010-01-01

Purpose This study explored whether breathing behaviors of infants within the second year of life differ between tidal breathing and breathing supporting single unarticulated syllables and canonical/articulated syllables. Method Vocalizations and breathing kinematics of nine infants between 53 and 90 weeks of age were recorded. A strict selection protocol was used to identify analyzable breath cycles. Syllables were categorized based on consensus coding. Inspiratory and expiratory durations, excursions, and slopes were calculated for the three breath cycle types and normalized using mean tidal breath measures. Results Tidal breathing cycles were significantly different from syllable-related cycles on all breathing measures. There were no significant differences between unarticulated syllable cycles and canonical syllable cycles, even after controlling for utterance duration and sound pressure level. Conclusions Infants in the second year of life exhibit clear differences between tidal breathing and speech-related breathing, but categorically distinct breath support for syllable types with varying articulatory demands was not evident in the current findings. Speech development introduces increasingly complex utterances, so older infants may produce detectable articulation-related adaptations of breathing kinematics. For younger infants, breath support may vary systematically among utterance types, due more to phonatory variations than to articulatory demands. PMID:21173390

A Viscoelastic earthquake simulator with application to the San Francisco Bay region

USGS Publications Warehouse

Pollitz, Fred F.

2009-01-01

Earthquake simulation on synthetic fault networks carries great potential for characterizing the statistical patterns of earthquake occurrence. I present an earthquake simulator based on elastic dislocation theory. It accounts for the effects of interseismic tectonic loading, static stress steps at the time of earthquakes, and postearthquake stress readjustment through viscoelastic relaxation of the lower crust and mantle. Earthquake rupture initiation and termination are determined with a Coulomb failure stress criterion and the static cascade model. The simulator is applied to interacting multifault systems: one, a synthetic two-fault network, and the other, a fault network representative of the San Francisco Bay region. The faults are discretized both along strike and along dip and can accommodate both strike slip and dip slip. Stress and seismicity functions are evaluated over 30,000 yr trial time periods, resulting in a detailed statistical characterization of the fault systems. Seismicity functions such as the coefficient of variation and a- and b-values exhibit systematic patterns with respect to simple model parameters. This suggests that reliable estimation of the controlling parameters of an earthquake simulator is a prerequisite to the interpretation of its output in terms of seismic hazard.

Inertial Range Turbulence of Fast and Slow Solar Wind at 0.72 AU and Solar Minimum

NASA Astrophysics Data System (ADS)

Teodorescu, Eliza; Echim, Marius; Munteanu, Costel; Zhang, Tielong; Bruno, Roberto; Kovacs, Peter

2015-05-01

We investigate Venus Express observations of magnetic field fluctuations performed systematically in the solar wind at 0.72 Astronomical Units (AU), between 2007 and 2009, during the deep minimum of solar cycle 24. The power spectral densities (PSDs) of the magnetic field components have been computed for time intervals that satisfy the data integrity criteria and have been grouped according to the type of wind, fast and slow, defined for speeds larger and smaller, respectively, than 450 km s-1. The PSDs show higher levels of power for the fast wind than for the slow. The spectral slopes estimated for all PSDs in the frequency range 0.005-0.1 Hz exhibit a normal distribution. The average value of the trace of the spectral matrix is -1.60 for fast solar wind and -1.65 for slow wind. Compared to the corresponding average slopes at 1 AU, the PSDs are shallower at 0.72 AU for slow wind conditions suggesting a steepening of the solar wind spectra between Venus and Earth. No significant time variation trend is observed for the spectral behavior of both the slow and fast wind.

The VMC survey. XI. Radial stellar population gradients in the galactic globular cluster 47 Tucanae

DOE Office of Scientific and Technical Information (OSTI.GOV)

Li, Chengyuan; De Grijs, Richard; Deng, Licai

2014-07-20

We present a deep near-infrared color-magnitude diagram of the Galactic globular cluster 47 Tucanae, obtained with the Visible and Infrared Survey Telescope for Astronomy (VISTA) as part of the VISTA near-infrared Y, J, K{sub s} survey of the Magellanic System (VMC). The cluster stars comprising both the subgiant and red giant branches exhibit apparent, continuous variations in color-magnitude space as a function of radius. Subgiant branch stars at larger radii are systematically brighter than their counterparts closer to the cluster core; similarly, red-giant-branch stars in the cluster's periphery are bluer than their more centrally located cousins. The observations can verymore » well be described by adopting an age spread of ∼0.5 Gyr as well as radial gradients in both the cluster's helium abundance (Y) and metallicity (Z), which change gradually from (Y = 0.28, Z = 0.005) in the cluster core to (Y = 0.25, Z = 0.003) in its periphery. We conclude that the cluster's inner regions host a significant fraction of second-generation stars, which decreases with increasing radius; the stellar population in the 47 Tuc periphery is well approximated by a simple stellar population.« less

Aerobic Oxidation of Xylose to Xylaric acid in Water over Pt Catalysts.

PubMed

Saha, Basudeb; Sadula, Sunitha

2018-05-02

Energy-efficient catalytic conversion of biomass intermediates to functional chemicals can enable bio-products viable. Herein, we report an efficient and low temperature aerobic oxidation of xylose to xylaric acid, a promising bio-based chemical for the production of glutaric acid, over commercial catalysts in water. Among several heterogeneous catalysts investigated, Pt/C exhibits the best activity. Systematic variation of reaction parameters in the pH range of 2.5 to 10 suggests that the reaction is fast at higher temperatures but high C-C scission of intermediate C5-oxidized products to low carbon carboxylic acids undermines xylaric acid selectivity. The C-C cleavage is also high in basic solution. The oxidation at neutral pH and 60 C achieves the highest xylaric acid yield (64%). O2 pressure and Pt-amount have significant influence on the reactivity. Decarboxylation of short chain carboxylic acids results in formation of CO2, causing some carbon loss; however such decarboxylation is slow in the presence of xylose. The catalyst retained comparable activity, in terms of product selectivity, after five cycles with no sign of Pt leaching. © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Analysis of gamma radiation from a radon source: Indications of a solar influence

NASA Astrophysics Data System (ADS)

Sturrock, P. A.; Steinitz, G.; Fischbach, E.; Javorsek, D.; Jenkins, J. H.

2012-08-01

This article presents an analysis of about 29,000 measurements of gamma radiation associated with the decay of radon in a sealed container at the Geological Survey of Israel (GSI) Laboratory in Jerusalem between 28 January 2007 and 10 May 2010. These measurements exhibit strong variations in time of year and time of day, which may be due in part to environmental influences. However, time-series analysis reveals a number of periodicities, including two at approximately 11.2 year-1 and 12.5 year-1. We have previously found these oscillations in nuclear-decay data acquired at the Brookhaven National Laboratory and at the Physiklisch-Technische Bundesanstalt, and we have suggested that these oscillations are attributable to some form of solar radiation that has its origin in the deep solar interior. A curious property of the GSI data is that the annual oscillation is much stronger in daytime data than in nighttime data, but the opposite is true for all other oscillations. This may be a systematic effect but, if it is not, this property should help narrow the theoretical options for the mechanism responsible for decay-rate variability.

Direct and indirect measurement of the magnetocaloric effect in bulk and nanostructured Ni-Mn-In Heusler alloy

NASA Astrophysics Data System (ADS)

Ghahremani, Mohammadreza; Aslani, Amir; Hosseinnia, Marjan; Bennett, Lawrence H.; Della Torre, Edward

2018-05-01

A systematic study of the magnetocaloric effect of a Ni51Mn33.4In15.6 Heusler alloy converted to nanoparticles via high energy ball-milling technique in the temperature range of 270 to 310 K has been performed. The properties of the particles were characterized by x-ray diffraction, electron microscopy, and magnetometer techniques. Isothermal magnetic field variation of magnetization exhibits field hysteresis in bulk Ni51Mn33.4In15.6 alloy across the martensitic transition which significantly lessened in the nanoparticles. The magnetocaloric effects of the bulk and nanoparticle samples were measured both with direct method, through our state of the art direct test bed apparatus with controllability over the applied fields and temperatures, as well as an indirect method through Maxwell and thermodynamic equations. In direct measurements, nanoparticle sample's critical temperature decreased by 6 K, but its magnetocaloric effect enhanced by 17% over the bulk counterpart. Additionally, when comparing the direct and indirect magnetocaloric curves, the direct method showed 14% less adiabatic temperature change in the bulk and 5% less adiabatic temperature change in the nanostructured sample.

Activities and prevalence of proteobacteria members colonizing Echinacea purpurea fully account for in vitro macrophage activation exhibited by extracts of this botanical

USDA-ARS?s Scientific Manuscript database

Evidence supports the theory that the bacterial communities colonizing E. purpurea contribute to the innate immune enhancing activity of this botanical. Previously we reported that only about half of the variation in in vitro monocyte stimulating activity exhibited by E. purpurea extracts could be a...

Activities and prevalence of proteobacteria members colonizing Echinacea purpurea fully account for in vitro macrophage activation exhibited by extracts of this botanical

USDA-ARS?s Scientific Manuscript database

Evidence supports the theory that bacterial communities colonizing Echinacea purpurea contribute to the innate immune enhancing activity of this botanical. Previously we reported that only about half of the variation in in vitro monocyte stimulating activity exhibited by E. purpurea extracts could ...

Revisiting the variation of clustering coefficient of biological networks suggests new modular structure.

PubMed

Hao, Dapeng; Ren, Cong; Li, Chuanxing

2012-05-01

A central idea in biology is the hierarchical organization of cellular processes. A commonly used method to identify the hierarchical modular organization of network relies on detecting a global signature known as variation of clustering coefficient (so-called modularity scaling). Although several studies have suggested other possible origins of this signature, it is still widely used nowadays to identify hierarchical modularity, especially in the analysis of biological networks. Therefore, a further and systematical investigation of this signature for different types of biological networks is necessary. We analyzed a variety of biological networks and found that the commonly used signature of hierarchical modularity is actually the reflection of spoke-like topology, suggesting a different view of network architecture. We proved that the existence of super-hubs is the origin that the clustering coefficient of a node follows a particular scaling law with degree k in metabolic networks. To study the modularity of biological networks, we systematically investigated the relationship between repulsion of hubs and variation of clustering coefficient. We provided direct evidences for repulsion between hubs being the underlying origin of the variation of clustering coefficient, and found that for biological networks having no anti-correlation between hubs, such as gene co-expression network, the clustering coefficient doesn't show dependence of degree. Here we have shown that the variation of clustering coefficient is neither sufficient nor exclusive for a network to be hierarchical. Our results suggest the existence of spoke-like modules as opposed to "deterministic model" of hierarchical modularity, and suggest the need to reconsider the organizational principle of biological hierarchy.

Compressed modes for variational problems in mathematics and physics

PubMed Central

Ozoliņš, Vidvuds; Lai, Rongjie; Caflisch, Russel; Osher, Stanley

2013-01-01

This article describes a general formalism for obtaining spatially localized (“sparse”) solutions to a class of problems in mathematical physics, which can be recast as variational optimization problems, such as the important case of Schrödinger’s equation in quantum mechanics. Sparsity is achieved by adding an regularization term to the variational principle, which is shown to yield solutions with compact support (“compressed modes”). Linear combinations of these modes approximate the eigenvalue spectrum and eigenfunctions in a systematically improvable manner, and the localization properties of compressed modes make them an attractive choice for use with efficient numerical algorithms that scale linearly with the problem size. PMID:24170861

Compressed modes for variational problems in mathematics and physics.

PubMed

Ozolins, Vidvuds; Lai, Rongjie; Caflisch, Russel; Osher, Stanley

2013-11-12

This article describes a general formalism for obtaining spatially localized ("sparse") solutions to a class of problems in mathematical physics, which can be recast as variational optimization problems, such as the important case of Schrödinger's equation in quantum mechanics. Sparsity is achieved by adding an regularization term to the variational principle, which is shown to yield solutions with compact support ("compressed modes"). Linear combinations of these modes approximate the eigenvalue spectrum and eigenfunctions in a systematically improvable manner, and the localization properties of compressed modes make them an attractive choice for use with efficient numerical algorithms that scale linearly with the problem size.

Variation in sulfur dioxide emissions related to earth tides, Halemaumau crater, Kilauea volcano, Hawaii

NASA Technical Reports Server (NTRS)

Connor, Charles B.; Stoiber, Richard E.; Malinconico, Lawrence L., Jr.

1988-01-01

Variation in SO2 emissions from Halemaumau crater, Kilauea volcano, Hawaii is analyzed using a set of techniques known as exploratory data analysis. SO2 flux was monitored using a correlation spectrometer. A total of 302 measurements were made on 73 days over a 90-day period. The mean flux was 171 t/d with a standard deviation of 52 t/d. A significant increase in flux occurs during increased seismic activity beneath the caldera. SO2 flux prior to this change varies in a systematic way and may be related to variation in the tidal modulation envelope.

Concerted copy number variation balances ribosomal DNA dosage in human and mouse genomes

PubMed Central

Gibbons, John G.; Branco, Alan T.; Godinho, Susana A.; Yu, Shoukai; Lemos, Bernardo

2015-01-01

Tandemly repeated ribosomal DNA (rDNA) arrays are among the most evolutionary dynamic loci of eukaryotic genomes. The loci code for essential cellular components, yet exhibit extensive copy number (CN) variation within and between species. CN might be partly determined by the requirement of dosage balance between the 5S and 45S rDNA arrays. The arrays are nonhomologous, physically unlinked in mammals, and encode functionally interdependent RNA components of the ribosome. Here we show that the 5S and 45S rDNA arrays exhibit concerted CN variation (cCNV). Despite 5S and 45S rDNA elements residing on different chromosomes and lacking sequence similarity, cCNV between these loci is strong, evolutionarily conserved in humans and mice, and manifested across individual genotypes in natural populations and pedigrees. Finally, we observe that bisphenol A induces rapid and parallel modulation of 5S and 45S rDNA CN. Our observations reveal a novel mode of genome variation, indicate that natural selection contributed to the evolution and conservation of cCNV, and support the hypothesis that 5S CN is partly determined by the requirement of dosage balance with the 45S rDNA array. We suggest that human disease variation might be traced to disrupted rDNA dosage balance in the genome. PMID:25583482

What I experienced yesterday is who I am today: relationship of work motivations and behaviors to within-individual variation in the five-factor model of personality.

PubMed

Judge, Timothy A; Simon, Lauren S; Hurst, Charlice; Kelley, Ken

2014-03-01

Historically, organizational and personality psychologists have ignored within-individual variation in personality across situations or have treated it as measurement error. However, we conducted a 10-day experience sampling study consistent with whole trait theory (Fleeson, 2012), which conceptualizes personality as a system of stable tendencies and patterns of intraindividual variation along the dimensions of the Big Five personality traits (Costa & McCrae, 1992). The study examined whether (a) internal events (i.e., motivation), performance episodes, and interpersonal experiences at work predict deviations from central tendencies in trait-relevant behavior, affect, and cognition (i.e., state personality), and (b) there are individual differences in responsiveness to work experiences. Results revealed that personality at work exhibited both stability and variation within individuals. Trait measures predicted average levels of trait manifestation in daily behavior at work, whereas daily work experiences (i.e., organizational citizenship, interpersonal conflict, and motivation) predicted deviations from baseline tendencies. Additionally, correlations of neuroticism with standard deviations in the daily personality variables suggest that, although work experiences influence state personality, people higher in neuroticism exhibit higher levels of intraindividual variation in personality than do those who are more emotionally stable.

A Teaching Exercise to Introduce Stable Isotope Fractionation of Metals into Geochemistry Courses

ERIC Educational Resources Information Center

Weiss, Dominik J.; Harris, Caroline; Maher, Kate; Bullen, Thomas

2013-01-01

Variations in the isotopic composition of elements have been widely used to study earth's climate, biosphere, and interior, and more recently to track the fate of contaminants. Within the broad range of elements that exhibit measureable isotopic variations, metal stable isotopes are increasingly applied across the biological, geological,…

Triticum mosaic virus exhibits limited population variation yet shows evidence of parallel evolution after replicated serial passage in wheat

USDA-ARS?s Scientific Manuscript database

An infectious cDNA clone of Triticum mosaic virus (TriMV) (genus Poacevirus; family Potyviridae) was used to establish three independent lineages in wheat to examine intra-host population diversity levels within protein 1 (P1) and coat protein (CP) cistrons over time. Genetic variation was assessed ...

Effect of foam age on toxicity of pyrolysis gases from polyurethane flexible foams

NASA Technical Reports Server (NTRS)

Hilado, C. J.; Murphy, R. M.

1978-01-01

The toxicity of the pyrolysis gases from some samples of polyurethane flexible foams appears to have decreased with age, while other samples seem to exhibit no significant change with age in this respect. The changes observed were greater than could be accounted for by variations in the material, or test variations or artifacts.

On the variability of LSI+61 deg 303 (identical with GT 0236)

NASA Technical Reports Server (NTRS)

Tanzi, E. G.; Bignami, G. F.; Caraveo, P. A.; Maraschi, L.; Sormani, F.; Treves, A.

1982-01-01

Out of six long and six short wavelength observations, one spectrum exhibits a significant photometric variation: or approximately 20%. Interpreting the continuum as due to superposition of an early B main sequence star plus a gaseous component contributing at lambda 2000 A, the wavelength dependence of the variation suggests that it derives from the latter component. The data indicate that if the observed variation is phase dependent, a minimum should occur between phases 0.8 and 0.2. However, since the variation is observed in only one spectrum, it may well be erratic.

Field-theoretic approach to fluctuation effects in neural networks

DOE Office of Scientific and Technical Information (OSTI.GOV)

Buice, Michael A.; Cowan, Jack D.; Mathematics Department, University of Chicago, Chicago, Illinois 60637

A well-defined stochastic theory for neural activity, which permits the calculation of arbitrary statistical moments and equations governing them, is a potentially valuable tool for theoretical neuroscience. We produce such a theory by analyzing the dynamics of neural activity using field theoretic methods for nonequilibrium statistical processes. Assuming that neural network activity is Markovian, we construct the effective spike model, which describes both neural fluctuations and response. This analysis leads to a systematic expansion of corrections to mean field theory, which for the effective spike model is a simple version of the Wilson-Cowan equation. We argue that neural activity governedmore » by this model exhibits a dynamical phase transition which is in the universality class of directed percolation. More general models (which may incorporate refractoriness) can exhibit other universality classes, such as dynamic isotropic percolation. Because of the extremely high connectivity in typical networks, it is expected that higher-order terms in the systematic expansion are small for experimentally accessible measurements, and thus, consistent with measurements in neocortical slice preparations, we expect mean field exponents for the transition. We provide a quantitative criterion for the relative magnitude of each term in the systematic expansion, analogous to the Ginsburg criterion. Experimental identification of dynamic universality classes in vivo is an outstanding and important question for neuroscience.« less

Thermal tolerance breadths among groundwater crustaceans living in a thermally constant environment.

PubMed

Mermillod-Blondin, F; Lefour, C; Lalouette, L; Renault, D; Malard, F; Simon, L; Douady, C J

2013-05-01

The climate variability hypothesis assumes that the thermal tolerance breadth of a species is primarily determined by temperature variations experienced in its environment. If so, aquatic invertebrates living in thermally buffered environments would be expected to exhibit narrow thermal tolerance breadths (stenothermy). We tested this prediction by studying the thermal physiology of three isopods (Asellidae, Proasellus) colonizing groundwater habitats characterized by an annual temperature amplitude of less than 1°C. The species responses to temperature variation were assessed in the laboratory using five physiological variables: survival, locomotor activity, aerobic respiration, immune defense and concentrations of total free amino acids and sugars. The three species exhibited contrasted thermal physiologies, although all variables were not equally informative. In accordance with the climate variability hypothesis, two species were extremely sensitive even to moderate changes in temperature (2°C) below and above their habitat temperature. In contrast, the third species exhibited a surprisingly high thermal tolerance breadth (11°C). Differences in response to temperature variation among Proasellus species indicated that their thermal physiology was not solely shaped by the current temperature seasonality in their natural habitats. More particularly, recent gene flow among populations living in thermally constant yet contrasted habitats might explain the occurrence of eurytherm species in thermally buffered environments.

Visualizing Intrapopulation Hematopoietic Cell Heterogeneity with Self-Organizing Maps of SIMS Data.

PubMed

Mirshafiee, Vahid; Harley, Brendan A C; Kraft, Mary L

2018-05-07

Characterization of the heterogeneity within stem cell populations, which affects their differentiation potential, is necessary for the design of artificial cultures for stem cell expansion. In this study, we assessed whether self-organizing maps (SOMs) of single-cell time-of-flight secondary ion mass spectrometry (TOF-SIMS) data provide insight into the spectral, and thus the related functional heterogeneity between and within three hematopoietic cell populations. SOMs were created of TOF-SIMS data from individual hematopoietic stem and progenitor cells (HSPCs), lineage-committed common lymphoid progenitors (CLPs), and fully differentiated B cells that had been isolated from murine bone marrow via conventional flow cytometry. The positions of these cells on the SOMs and the spectral variation between adjacent map units, shown on the corresponding unified distance matrix (U-matrix), indicated the CLPs exhibited the highest intrapopulation spectral variation, regardless of the age of the donor mice. SOMs of HSPCs, CLPs, and B cells isolated from young and old mice using the same surface antigen profiles revealed the HSPCs exhibited the most age-related spectral variation, whereas B cells exhibited the least. These results demonstrate that SOMs of single-cell spectra enable characterizing the heterogeneity between and within cell populations that lie along distinct differentiation pathways.

Information theory and the neuropeptidergic regulation of seasonal reproduction in mammals and birds

PubMed Central

Stevenson, Tyler J.; Ball, Gregory F.

2011-01-01

Seasonal breeding in the temperate zone is a dramatic example of a naturally occurring change in physiology and behaviour. Cues that predict periods of environmental amelioration favourable for breeding must be processed by the brain so that the appropriate responses in reproductive physiology can be implemented. The neural integration of several environmental cues converges on discrete hypothalamic neurons in order to regulate reproductive physiology. Gonadotrophin-releasing hormone-1 (GnRH1) and Kisspeptin (Kiss1) neurons in avian and mammalian species, respectively, show marked variation in expression that is positively associated with breeding state. We applied the constancy/contingency model of predictability to investigate how GnRH1 and Kiss1 integrate different environmental cues to regulate reproduction. We show that variation in GnRH1 from a highly seasonal avian species exhibits a predictive change that is primarily based on contingency information. Opportunistic species have low measures of predictability and exhibit a greater contribution of constancy information that is sex-dependent. In hamsters, Kiss1 exhibited a predictive change in expression that was predominantly contingency information and is anatomically localized. The model applied here provides a framework for studies geared towards determining the impact of variation in climate patterns to reproductive success in vertebrate species. PMID:21208957

Compositional Zoning and Mn-Cr Systematics in Carbonates from the Y791198 CM2 Carbonaceous Chondrite

NASA Technical Reports Server (NTRS)

Brearley, Adrian J.; Hutcheon, Ian D.; Browning, Lauren

2001-01-01

Cathodoluminescence and microprobe analyses show that carbonates in Y791198 exhibit complex zoning. Cr-Mn dating suggests formation of carbonates 10 Ma after CAI formation Additional information is contained in the original extended abstract..

HE 0017+0055: A probable pulsating CEMP-rs star and long-period binary

NASA Astrophysics Data System (ADS)

Jorissen, A.; Hansen, T.; Van Eck, S.; Andersen, J.; Nordström, B.; Siess, L.; Torres, G.; Masseron, T.; Van Winckel, H.

2016-02-01

Context. A large fraction of the carbon-enhanced, extremely metal-poor halo giants ([Fe/H] < -2.5) are also strongly enriched in neutron-capture elements from the s process (CEMP-s stars). The conventional explanation for the properties of these stars is mass transfer from a nearby binary companion on the asymptotic giant branch (AGB). This scenario leads to a number of testable predictions in terms of the properties of the putative binary system and the resulting abundance pattern. Among the CEMP stars, some stars further exhibit overabundances in r-process elements on top of the s-process enrichment, and are tagged CEMP-rs stars. Although the nucleosynthesis process responsible for this kind of mixed abundance pattern is still under debate, CEMP-rs stars seem to belong to binary systems as do CEMP-s stars. Aims: Our aim is to present and analyse in detail our comprehensive data set of systematic radial-velocity measurements and high-resolution spectroscopy of the CEMP star HE 0017+0055. Methods: Our precise radial-velocity monitoring of HE 0017+0055 over 2940 days (8 yr) with the Nordic Optical Telescope and Mercator telescopes exhibits variability, with a period of 384 d and amplitude of 540 ± 27 m s-1 superimposed on a nearly linear long-term decline of ~1 m s-1 day-1. We used high-resolution HERMES/Mercator and Keck/HIRES spectra to derive elemental abundances with 1D LTE MARCS models. A metallicity of [Fe/H] ~ -2.4 is found, along with s-process overabundances of the order of 2 dex (with the exception of [Y/Fe] ~ + 0.5), and most notably overabundances of r-process elements like Sm, Eu, Dy, and Er in the range 0.9-2.0 dex. With [Ba/Fe] > 1.9 dex and [Eu/Fe] = 2.3 dex, HE 0017+0055 is a CEMP-rs star. We used the derived atmospheric parameters and abundances to infer HE 0017+0055 evolutionary status from a comparison with evolutionary tracks. Results: HE 0017+0055 appears to be a giant star below the tip of the red giant branch. The s-process pollution must therefore originate from mass transfer from a companion formerly on the AGB, which is now a carbon-oxygen white dwarf (WD). If the 384 d velocity variations are attributed to the WD companion, its orbit must be seen almost face-on, with I ~ 2.3°, because the mass function is very small: f(M1,M2) = (6.1 ± 1.1) × 10-6M⊙. Alternatively, the WD orbital motion could be responsible for the long-term velocity variations, with a period of several decades. The 384 d variations should then be attributed either to a low-mass inner companion (perhaps a brown dwarf, depending on the orbital inclination), or to stellar pulsations. The latter possibility is made likely by the fact that similar low-amplitude velocity variations, with periods close to 1 yr, have been reported for other CEMP stars in a companion paper. A definite conclusion about the origin of the 384 d velocity variations should however await the detection of synchronous low-amplitude photometric variations. Based on observations performed with the Mercator telescope and the Nordic Optical Telescope (NOT), operated by the Nordic Optical Telescope Scientific Association at the Roque de los Muchachos Observatory, La Palma, Spain, of the Instituto de Astrofïsica de Canarias.

THE EFFECTS OF SYSTEMATIC VARIATION OF SPEED AND DIRECTION OF OBJECT FLIGHT AND OF SKILL AND AGE CLASSIFICATIONS UPON VISUO-PERCEPTUAL JUDGMENTS OF MOVING OBJECTS IN THREE-DIMENSIONAL SPACE. FINAL REPORT.

ERIC Educational Resources Information Center

WILLIAMS, HARRIET G.

THIS STUDY WAS CONDUCTED TO INVESTIGATE THE EFFECTS OF VARIATIONS IN THE SPEED AND DIRECTION OF A FLYING OBJECT ON VISUO-PERCEPTUAL JUDGMENTS MADE, DIFFERENCES IN THE ABILITY OF SKILLED AND UNSKILLED SUBJECTS IN MAKING SUCH JUDGMENTS, AND THE EFFECTS OF AGE OR MATURITY LEVEL ON THE SPEED AND ACCURACY OF SUCH JUDGMENTS. THE SUBJECTS WERE 54 MALE…

Evolutionary variational-hemivariational inequalities

NASA Astrophysics Data System (ADS)

Carl, Siegfried; Le, Vy K.; Motreanu, Dumitru

2008-09-01

We consider an evolutionary quasilinear hemivariational inequality under constraints represented by some closed and convex subset. Our main goal is to systematically develop the method of sub-supersolution on the basis of which we then prove existence, comparison, compactness and extremality results. The obtained results are applied to a general obstacle problem. We improve the corresponding results in the recent monograph [S. Carl, V.K. Le, DE Motreanu, Nonsmooth Variational Problems and Their Inequalities. Comparison Principles and Applications, Springer Monogr. Math., Springer, New York, 2007].

Spatial and Temporal Variations of Infrared Emissions in the Upper Atmosphere. 3. 5.3-μm Nitric Oxide Emission

NASA Astrophysics Data System (ADS)

Semenov, A. I.; Medvedeva, I. V.; Perminov, V. I.

2018-03-01

The results of rocket and satellite measurements available in the literature of 5.3-μm nitric oxide emission in the upper atmosphere have been systematized and analyzed. Analytical dependences describing the height distribution of volumetric intensity of 5.3-μm emission of the NO molecule and its variations in a range of heights from 100 to 130 km as a function of the time of year, day, latitude, and solar activity have been obtained.

Revisiting the concept of Redfield ratios applied to plankton stoichiometry - Addressing model uncertainties with respect to the choice of C:N:P ratios for phytoplankton

NASA Astrophysics Data System (ADS)

Kreus, Markus; Paetsch, Johannes; Grosse, Fabian; Lenhart, Hermann; Peck, Myron; Pohlmann, Thomas

2017-04-01

Ongoing Ocean Acidification (OA) and climate change related trends impact on physical (temperature), chemical (CO2 buffer capacity) and biological (stoichiometric) properties of the marine environment. These threats affect the global ocean but they appear particularly pronounced in marginal and shelf seas. Marine biogeochemical models are often used to investigate the impacts of climate change and changes in OA on the marine system as well as its exchange with the atmosphere. Different studies showed that both the structural composition of the models and the elemental ratios of particulate organic matter in the surface ocean affect the key processes controlling the ocean's efficiency storing atmospheric excess carbon. Recent studies focus on the variability of the elemental ratios of phytoplankton and found that the high plasticity of C:N:P ratios enables the storage of large amounts of carbon by incorporation into carbohydrates and lipids. Our analysis focuses on the North Sea, a temperate European shelf sea, for the period 2000-2014. We performed an ensemble of model runs differing only in phytoplankton stoichiometry, representing combinations of C:P = [132.5, 106, 79.5] and N:P=[20, 16, 12] (i.e., Redfield ratio +/- 25%). We examine systematically the variations in annual averages of net primary production (NPP), net ecosystem production in the upper 30 m (NEP30), export production below 30 m depth (EXP30), and the air-sea flux of CO2 (ASF). Ensemble average fluxes (and standard deviations) resulted in NPP = 15.4 (2.8) mol C m-2 a-1, NEP30 = 5.4 (1.1) mol C m-2 a-1, EXP30 = 8.1 (1.1) mol C m-2 a-1 and ASF = 1.1 (0.5) mol C m-2 a-1. All key parameters exhibit only minor variations along the axis of constant C:N, but correlate positively with increasing C:P and decreasing N:P ratios. Concerning regional differences, lowest variations in local fluxes due to different stoichiometric ratios can be found in the shallow southern and coastal North Sea. Highest variations appear in the central and northern North Sea with persistent seasonal stratification. Our results show that a moderate variation of the elemental ratios of phytoplankton, which can be found in literature, yields relatively strong variations in marine biochemical key processes. This puts emphasis on the uncertainties in predicting ecosystem response to OA or climate change using ecosystem models.

Multifractal spectrum and lacunarity as measures of complexity of osseointegration.

PubMed

de Souza Santos, Daniel; Dos Santos, Leonardo Cavalcanti Bezerra; de Albuquerque Tavares Carvalho, Alessandra; Leão, Jair Carneiro; Delrieux, Claudio; Stosic, Tatijana; Stosic, Borko

2016-07-01

The goal of this study is to contribute to a better quantitative description of the early stages of osseointegration, by application of fractal, multifractal, and lacunarity analysis. Fractal, multifractal, and lacunarity analysis are performed on scanning electron microscopy (SEM) images of titanium implants that were first subjected to different treatment combinations of i) sand blasting, ii) acid etching, and iii) exposition to calcium phosphate, and were then submersed in a simulated body fluid (SBF) for 30 days. All the three numerical techniques are applied to the implant SEM images before and after SBF immersion, in order to provide a comprehensive set of common quantitative descriptors. It is found that implants subjected to different physicochemical treatments before submersion in SBF exhibit a rather similar level of complexity, while the great variety of crystal forms after SBF submersion reveals rather different quantitative measures (reflecting complexity), for different treatments. In particular, it is found that acid treatment, in most combinations with the other considered treatments, leads to a higher fractal dimension (more uniform distribution of crystals), lower lacunarity (lesser variation in gap sizes), and narrowing of the multifractal spectrum (smaller fluctuations on different scales). The current quantitative description has shown the capacity to capture the main features of complex images of implant surfaces, for several different treatments. Such quantitative description should provide a fundamental tool for future large scale systematic studies, considering the large variety of possible implant treatments and their combinations. Quantitative description of early stages of osseointegration on titanium implants with different treatments should help develop a better understanding of this phenomenon, in general, and provide basis for further systematic experimental studies. Clinical practice should benefit from such studies in the long term, by more ready access to implants of higher quality.

Bold Colors in a Cryptic Lineage: Do Eastern Indigo Snakes Exhibit Color Dimorphism?

PubMed Central

Deitloff, Jennifer; Johnson, Valerie M.; Guyer, Craig

2013-01-01

Many species exhibit variation in the color of their scales, feathers, or fur. Various forms of natural selection, such as mimicry, crypsis, and species recognition, as well as sexual selection, can influence the evolution of color. Eastern Indigo Snakes (Drymarchon couperi), a federally threatened species, have coloration on the sides of the head and the chin that can vary from black to red or cream. Despite significant conservations efforts for this species, little is known about its biology in the field. Past researchers have proposed that the color variation on the head and chin is associated with the sex of the individual. Alternatively, color might vary among individuals because it is controlled by genes that are under natural selection or neutral evolution. We tested these alternative hypotheses by examining whether coloration of the sublabial, submaxillary, and ventral scales of this species differed by sex or among clutches. We used color spectrometry to characterize important aspects of color in two ways: by examining overall color differences across the entire color spectrum and by comparing differences within the ultraviolet, yellow, and red colorbands. We found that Eastern Indigo Snakes do not exhibit sexual dichromatism, but their coloration does vary among clutches; therefore, the pattern of sexual selection leading to sexual dichromatism observed in many squamates does not appear to play a role in the evolution and maintenance of color variation in Eastern Indigo Snakes. We suggest that future studies should focus on determining whether color variation in these snakes is determined by maternal effects or genetic components and if color is influenced by natural selection or neutral evolutionary processes. Studying species that exhibit bright colors within lineages that are not known for such coloration will contribute greatly to our understanding of the evolutionary and ecological factors that drive these differences. PMID:23691245

Spatial variation in the climatic predictors of species compositional turnover and endemism

PubMed Central

Di Virgilio, Giovanni; Laffan, Shawn W; Ebach, Malte C; Chapple, David G

2014-01-01

Previous research focusing on broad-scale or geographically invariant species-environment dependencies suggest that temperature-related variables explain more of the variation in reptile distributions than precipitation. However, species–environment relationships may exhibit considerable spatial variation contingent upon the geographic nuances that vary between locations. Broad-scale, geographically invariant analyses may mask this local variation and their findings may not generalize to different locations at local scales. We assess how reptile–climatic relationships change with varying spatial scale, location, and direction. Since the spatial distributions of diversity and endemism hotspots differ for other species groups, we also assess whether reptile species turnover and endemism hotspots are influenced differently by climatic predictors. Using New Zealand reptiles as an example, the variation in species turnover, endemism and turnover in climatic variables was measured using directional moving window analyses, rotated through 360°. Correlations between the species turnover, endemism and climatic turnover results generated by each rotation of the moving window were analysed using multivariate generalized linear models applied at national, regional, and local scales. At national-scale, temperature turnover consistently exhibited the greatest influence on species turnover and endemism, but model predictive capacity was low (typically r2 = 0.05, P < 0.001). At regional scales the relative influence of temperature and precipitation turnover varied between regions, although model predictive capacity was also generally low. Climatic turnover was considerably more predictive of species turnover and endemism at local scales (e.g., r2 = 0.65, P < 0.001). While temperature turnover had the greatest effect in one locale (the northern North Island), there was substantial variation in the relative influence of temperature and precipitation predictors in the remaining four locales. Species turnover and endemism hotspots often occurred in different locations. Climatic predictors had a smaller influence on endemism. Our results caution against assuming that variability in temperature will always be most predictive of reptile biodiversity across different spatial scales, locations and directions. The influence of climatic turnover on the species turnover and endemism of other taxa may exhibit similar patterns of spatial variation. Such intricate variation might be discerned more readily if studies at broad scales are complemented by geographically variant, local-scale analyses. PMID:25473479

Along and Across Arc Variation of the Central Andes by Single Crystal Trace Element Analaysis

NASA Astrophysics Data System (ADS)

Michelfelder, G.; Sundell, T.; Wilder, A.; Salings, E. E.

2017-12-01

Along arc and across arc geochemical variations at continental volcanic arcs are influenced by a number of factors including the composition and thickness of the continental crust, mantle heterogeneity, and fluids from the subducted slab. Whole rock geochemical trends along and across the arc front of the Central Volcanic Zone (CVZ) have been suggested to be primarily influenced by the composition and thickness of the crust. In the CVZ, Pb isotopic domains relate volcanic rock compositions to the crustal basement and systematically varies with crustal age. It has been shown repeatedly that incompatible trace element trends and trace element ratios can be used to infer systematic geochemical changes. However, there is no rule linking magmatic process or chemical heterogeneity/ homogeneity as a result of large crustal magma storage reservoirs such as MASH zones to the observed variation. Here we present a combination of whole rock major- and trace element data, isotopic data and in situ single crystal data from plagioclase, pyroxene and olivine for six stratovolcanoes along the arc front and in the back arc of the CVZ. We compare geochemical trends at the whole and single crystal scale. These volcanoes include lava flows and domes from Cerro Uturuncu in the back-arc, Aucanquilcha, Ollagüe, San Pedro-San Pablo, Lascar, and Lazufre from the arc front. On an arc-wide scale, whole rock samples of silicic lavas from these six composite volcanoes display systematically higher K2O, LILE, REE and HFSE contents and 87Sr/86Sr ratios with increasing distance from the arc-front. In contrast, the lavas have systematically lower Na2O, Sr, and Ba contents; LILE/HFSE ratios; 143Nd/144Nd ratios; and more negative Eu anomalies. Silicic magmas along the arc-front reflecting melting of young, mafic composition source rocks with the continental crust becoming increasingly older and more felsic toward the east. These trends are paralleled in the trace element compositions of plagioclase cores which systematically become less diverse in composition in younger lava flows from each center. We suggest these trends result from progressively smaller degrees of mantle partial melting, primary melt generation, and crustal hybridization with distance from the arc-front and varying influence of MASH zone processes.

Patterned variation in prehistoric chiefdoms

PubMed Central

Drennan, Robert D.; Peterson, Christian E.

2006-01-01

Comparative study of early complex societies (chiefdoms) conjures visions of a cultural evolutionary emphasis on similarities and societal typology. Variation within the group has not been as systematically examined but offers an even more productive avenue of approach to fundamental principles of organization and change. Three widely separated trajectories of early chiefdom development are compared here: the Valley of Oaxaca (Mexico), the Alto Magdalena (Colombia), and Northeast China. Archaeological data from all three regions are analyzed with the same tools to reveal variation in human activities, relationships, and interactions as these change in the emergence of chiefly communities. Patterning in this variation suggests the operation of underlying general principles, which are offered as hypotheses that merit further investigation and evaluation in comparative study of a much larger number of cases. PMID:16473941

Genetic, molecular and physiological basis of variation in Drosophila gut immunocompetence.

PubMed

Bou Sleiman, Maroun S; Osman, Dani; Massouras, Andreas; Hoffmann, Ary A; Lemaitre, Bruno; Deplancke, Bart

2015-07-27

Gut immunocompetence involves immune, stress and regenerative processes. To investigate the determinants underlying inter-individual variation in gut immunocompetence, we perform enteric infection of 140 Drosophila lines with the entomopathogenic bacterium Pseudomonas entomophila and observe extensive variation in survival. Using genome-wide association analysis, we identify several novel immune modulators. Transcriptional profiling further shows that the intestinal molecular state differs between resistant and susceptible lines, already before infection, with one transcriptional module involving genes linked to reactive oxygen species (ROS) metabolism contributing to this difference. This genetic and molecular variation is physiologically manifested in lower ROS activity, lower susceptibility to ROS-inducing agent, faster pathogen clearance and higher stem cell activity in resistant versus susceptible lines. This study provides novel insights into the determinants underlying population-level variability in gut immunocompetence, revealing how relatively minor, but systematic genetic and transcriptional variation can mediate overt physiological differences that determine enteric infection susceptibility.

Magnetic properties of intermetallic compounds La(Ni,Co,Cu)3

NASA Astrophysics Data System (ADS)

Tazuke, Y.; Tanikawa, H.; Okano, A.; Miyaji, T.

2006-09-01

LaNi3 exhibited a metallic antiferromagnetic property with T N = 30 K. La(Ni1-x Cox )3 with x = 0.01, 0.03 and 0.05 exhibited ferromagnetic properties, T C increasing linearly with increasing x . La(Ni1-2z Coz Cuz )3 with z = 0.015 exhibited a ferromagnetic property with a small T C. A La(Ni1-y Cuy )3 sample with y = 0.01 exhibited a Pauli-paramagnetic property; those with y = 0.02, 0.03 and 0.04 exhibited gradual metamagnetic behavior and that with y = 0.05 exhibited a ferromagnetic property. The gradual metamagnetic M -H variations are numerically simulated by using Landau-type free energies. The results suggest that the gradual metamagnetic behavior occurs from an antiferromagnetic state to a ferromagnetic one.

Plumage development and molt in Long-tailed Manakins (Chiroxiphia linearis): Variation according to sex and age

USGS Publications Warehouse

Doucet, S.M.; McDonald, D.B.; Foster, M.S.; Clay, R.P.

2007-01-01

Lek-mating Long-tailed Manakins (Chiroxiphia linearis) exhibit an unusual pattern of delayed plumage maturation. Each year, males progress through a series of predefinitive plumages before attaining definitive plumage in their fifth calendar year. Females also exhibit variation in plumage coloration, with some females displaying male-like plumage characteristics. Using data from mist-net captures in northwest Costa Rica (n = 1,315) and museum specimens from throughout the range of Long-tailed Manakins (n = 585), we documented the plumage sequence progression of males, explored variation in female plumage, and described the timing of molt in this species. Males progressed through a series of age-specific predefinitive plumages, which enabled the accurate aging of predefinitive-plumaged males in the field; this predefinitive plumage sequence is the basis for age-related status-signaling in these males. Females tended to acquire red coloration in the crown as they aged. However, colorful plumage in females may be a byproduct of selection on bright male plumage. Females exhibited an early peak of molt activity from February to April, little molt from May through July, and a second, more pronounced peak of molt activity in October. By contrast, males in older predefinitive-plumage stages and males in definitive plumage exhibited comparable unimodal distributions in molt activity beginning in June and peaking between July and October. Our data are consistent with selective pressure to avoid the costs of molt-breeding overlap in females and older males. Our findings have important implications for social organization and signaling in Long- tailed Manakins, and for the evolution of delayed plumage maturation in birds.

Late Reduction Textures in Almahata Sitta Ureilite

NASA Technical Reports Server (NTRS)

Herrin, J. S.; Le, L.; Zolensky, M. E.; Ito, M.; Jenniskens, P.; Shaddad, M. H.

2009-01-01

The Almahata Sitta ureilite, derived from asteroid 2008 TC3, consists of many individual fragments recovered from the Nubian dessert strewn field [1]. Like most ureilites, it contains abundant carbon and exhibits examples of disequilibrium textures that record a late reduction event accompanied by rapid cooling (tens of degC/h) from high temperatures (1150-1300 C). Variations in Fe/Mg of silicate minerals are accompanied by variations in Fe/Mn, indicating loss of Fe into metal [2]. In coarser-grained fragments of Almahata Sitta, olivine exhibits irregular high mg# rims in contact with networks of interstitial metal 5- 20 microns in typical thickness. This is a common ureilite texture thought to be driven by the reaction of graphite to a CO gas phase and the concurrent reduction of FeO in olivine to Fe metal, with excess silica going primarily into pyroxene (2MgFeSiO4 + C approaches MgSiO4 + MgSiO3 + 2Fe + CO) [3, see also 4,5,6]. Other fragments of Almahata Sitta exhibit anomalous textures such as fine grain size, high porosity, and abundant graphite. Within these fragments pyroxene locally exhibits high-mg# rims in contact with metal and a discreet silica phase, suggesting that the reduction mechanism MgFeSi2O6 + C approaches MgSiO3 + Fe + SiO2 + CO. Metals in Almahata Sitta are particularly unaltered in comparison to ureilite finds. Variations in minor and trace element composition of this metal might partly result from localized dilution as iron is supplied by reduction of silicates.

Determining the effects of dams on subdaily variation in river flows at a whole-basin scale

USGS Publications Warehouse

Zimmerman, J.K.H.; Letcher, B.H.; Nislow, K.H.; Lutz, K.A.; Magilligan, F.J.

2010-01-01

River regulation can alter the frequency and magnitude of subdaily flow variations causing major impacts on ecological structure and function. We developed an approach to quantify subdaily flow variation for multiple sites across a large watershed to assess the potential impacts of different dam operations (flood control, run-of-river hydropower and peaking hydropower) on natural communities. We used hourly flow data over a 9-year period from 30 stream gages throughout the Connecticut River basin to calculate four metrics of subdaily flow variation and to compare sites downstream of dams with unregulated sites. Our objectives were to (1) determine the temporal scale of data needed to characterize subdaily variability; (2) compare the frequency of days with high subdaily flow variation downstream of dams and unregulated sites; (3) analyse the magnitude of subdaily variation at all sites and (4) identify individual sites that had subdaily variation significantly higher than unregulated locations. We found that estimates of flow variability based on daily mean flow data were not sufficient to characterize subdaily flow patterns. Alteration of subdaily flows was evident in the number of days natural ranges of variability were exceeded, rather than in the magnitude of subdaily variation, suggesting that all rivers may exhibit highly variable subdaily flows, but altered rivers exhibit this variability more frequently. Peaking hydropower facilities had the most highly altered subdaily flows; however, we observed significantly altered ranges of subdaily variability downstream of some flood-control and run-of-river hydropower dams. Our analysis can be used to identify situations where dam operating procedures could be modified to reduce the level of hydrologic alteration. ?? 2009 John Wiley & Sons, Ltd.

Spatiotemporal variation of radon and carbon dioxide concentrations in an underground quarry: coupled processes of natural ventilation, barometric pumping and internal mixing.

PubMed

Perrier, Frédéric; Richon, Patrick

2010-04-01

Radon-222 and carbon dioxide concentrations have been measured during several years at several points in the atmosphere of an underground limestone quarry located at a depth of 18 m in Vincennes, near Paris, France. Both concentrations showed a seasonal cycle. Radon concentration varied from 1200 to 2000 Bq m(-3) in summer to about 800-1400 Bq m(-3) in winter, indicating winter ventilation rates varying from 0.6 to 2.5 x 10(-6) s(-1). Carbon dioxide concentration varied from 0.9 to 1.0% in summer, to about 0.1-0.3% in winter. Radon concentration can be corrected for natural ventilation using temperature measurements. The obtained model also accounts for the measured seasonal variation of carbon dioxide. After correction, radon concentrations still exhibit significant temporal variation, mostly associated with the variation of atmospheric pressure, with coupling coefficients varying from -7 to -26 Bq m(-3) hPa(-1). This variation can be accounted for using a barometric pumping model, coupled with natural ventilation in winter, and including internal mixing as well. After correction, radon concentrations exhibit residual temporal variation, poorly correlated between different points, with standard deviations varying from 3 to 6%. This study shows that temporal variation of radon concentrations in underground cavities can be understood to a satisfactory level of detail using non-linear and time-dependent modelling. It is important to understand the temporal variation of radon concentrations and the limitations in their modelling to monitor the properties of natural or artificial underground settings, and to be able to assess the existence of new processes, for example associated with the preparatory phases of volcanic eruptions or earthquakes. Copyright 2009 Elsevier Ltd. All rights reserved.

Sodium ion channel alkaloid resistance does not vary with toxicity in aposematic Dendrobates poison frogs: An examination of correlated trait evolution

PubMed Central

Wang, Ian J.

2018-01-01

Spatial heterogeneity in the strength or agents of selection can lead to geographic variation in ecologically important phenotypes. Many dendrobatid frogs sequester alkaloid toxins from their diets and often exhibit fixed mutations at NaV1.4, a voltage-gated sodium ion channel associated with alkaloid toxin resistance. Yet previous studies have noted an absence of resistance mutations in individuals from several species known to sequester alkaloid toxins, suggesting possible intraspecific variation for alkaloid resistance in these species. Toxicity and alkaloid profiles vary substantially between populations in several poison frog species (genus Dendrobates) and are correlated with variation in a suite of related traits such as aposematic coloration. If resistance mutations are costly, due to alterations of channel gating properties, we expect that low toxicity populations will have reduced frequencies and potentially even the loss of resistance alleles. Here, we examine whether intraspecific variation in toxicity in three dendrobatid frogs is associated with intraspecific variation in alleles conferring toxin resistance. Specifically, we examine two species that display marked variation in toxicity throughout their native ranges (Dendrobates pumilio and D. granuliferus) and one species with reduced toxicity in its introduced range (D. auratus). However, we find no evidence for population-level variation in alkaloid resistance at NaV1.4. In fact, contrary to previous studies, we found that alkaloid resistance alleles were not absent in any populations of these species. All three species exhibit fixed alkaloid resistance mutations throughout their ranges, suggesting that these mutations are maintained even when alkaloid sequestration is substantially reduced. PMID:29534110

Mycelial growth rate and toxin production in the seed pathogen Pyrenophora semeniperda: Resource trade-offs and temporally varying selection

Treesearch

S. E. Meyer; M. Masi; S. Clement; T. L. Davis; J. Beckstead

2015-01-01

Pyrenophora semeniperda, an important pathogen in Bromus tectorum seed banks in semi-arid western North America, exhibits >4-fold variation in mycelial growth rate. Host seeds exhibit seasonal changes in dormancy that affect the risk of pathogen-caused mortality. The hypothesis tested is that contrasting seed dormancy phenotypes select for contrasting strategies...

New Synthesis Of Poly(1,3,4-Oxadiazoles)

NASA Technical Reports Server (NTRS)

Connell, John W.; Hergenrother, Paul M.; Wolf, Peter

1992-01-01

Synthesis via aromatic nucleophilic displacement yields new high-molecular-weight polymers. Polymers exhibited good mechanical and thermal properties. Synthetic route provided high-molecular-weight POX of new chemical structure, potentially more economical. Availability of large variety of activated aromatic dihalides, facilitates variation of chemical structures. Exhibit properties making them useful as films. Also useful in coatings, adhesives, moldings, and composites.

Effects of Nanoparticle Size on Cellular Uptake and Liver MRI with PVP-Coated Iron Oxide Nanoparticles

PubMed Central

Huang, Jing; Bu, Lihong; Xie, Jin; Chen, Kai; Cheng, Zhen; Li, Xingguo; Chen, Xiaoyuan

2010-01-01

The effect of nanoparticle size (30–120 nm) on magnetic resonance imaging (MRI) of hepatic lesions in vivo has been systematically examined using polyvinylpyrrolidone (PVP)-coated iron oxide nanoparticles (PVP-IOs). Such biocompatible PVP-IOs with different sizes were synthesized by a simple one-pot pyrolysis method. These PVP-IOs exhibited good crystallinity and high T2 relaxivities, and the relaxivity increased with the size of the magnetic nanoparticles. It was found that cellular uptake changed with both size and surface physiochemical properties, and that PVP-IO-37 with a core size of 37 nm and hydrodynamic particle size of 100 nm exhibited higher cellular uptake rate and greater distribution than other PVP-IOs and Feridex. We systematically investigated the effect of nanoparticle size on MRI of normal liver and hepatic lesions in vivo. The physical and chemical properties of the nanoparticles influenced their pharmacokinetic behavior, which ultimately determined their ability to accumulate in the liver. The contrast enhancement of PVP-IOs within the liver was highly dependent on the overall size of the nanoparticles, and the 100 nm PVP-IO-37 nanoparticles exhibited the greatest enhancement. These results will have implications in designing engineered nanoparticles that are optimized as MR contrast agents or for use in therapeutics. PMID:21043459

The Determinants of Library Subscription Prices of the Top-Ranked Economics Journals: An Econometric Analysis.

ERIC Educational Resources Information Center

Chressanthis, George A.; Chressanthis, June D.

1994-01-01

Asserts that subscription price increases for academic journals have been the area of single greatest concern to librarians during the past decade. Finds that systematic variations in library prices across economics journals offer explainable reasons. (CFR)

System among the Two-Stems.

ERIC Educational Resources Information Center

Murphy, David T.

1984-01-01

Proposes a variation of the two-stem system of analyzing the Russian verb. The need for greater organization and systematization is stressed, as well as an increased focus on the great regularity of the Russian verb, and the relative simplicity of Russian verbal morphology. (SL)

Collapsing Containers.

ERIC Educational Resources Information Center

Brown, Justina L.; Battino, Rubin

1994-01-01

Describes variations on atmospheric pressure demonstrations and some systematic studies. Demonstrations use steam, generated either externally or internally to the container, to sweep out residual air. Preferred vessels collapsed slowly. Demonstrations use plastic milk jugs set in layers of aluminum foil, pop bottles immersed in 4-L beakers…

Genetic variation in carbon isotope discrimination and its relationship to growth under field conditions in full-sib families of Picea mariana

Treesearch

Lawrence B. Flanagan; Kurt H. Johnsen

1995-01-01

Measurements of the stable carbon isotope composition of leaf tissue were made on Picea mariana (Mill.) B.S.P. trees from four full-sib families grown on three different field sites at the Petawawa National Forestry Institute, Ontario, Canada. The four families chosen exhibited genetic variation for growth characteristics. Genetic...

Marine stratocumulus structure

NASA Technical Reports Server (NTRS)

Cahalan, Robert F.; Snider, Jack B.

1989-01-01

Thirty-three Landsat TM scenes of California stratocumulus cloud fields were acquired as part of the FIRE Marine Stratocumulus Intensive Field Observations in July 1987. They exhibit a wide variety of stratocumulus structures. Analysis has so far focused upon the July 7 scene, in which aircraft from NASA, NCAR, and the British Meteorological Office repeatedly gathered data across a stratocumulus-fair weather cumulus transition. The aircraft soundings validate the cloud base temperature threshold determined by spatial coherence analysis of the TM thermal band. Brightness variations in the stratocumulus region exhibit a -5/3 power-law decrease of the wavenumber spectra for scales larger than the cloud thickness, about 200 m, changing to a -3 power at smaller scales. Observations by an upward-looking three-channel microwave radiometer on San Nicolas Island also show the -5/3 power-law in total integrated liquid water, suggesting that the largest-scale TM brightness variations are primarily due to variations in the liquid water. The Kolmogorov 5/3 power suggests that for some purposes liquid water in turbulent stratocumulus clouds may be treated as a passive scalar, simply reflecting variations in vertical velocity. This may be tested using the velocities measured by the aircraft.

Genetic Structure of First Nation Communities in the Pacific Northwest.

PubMed

Hughes, Cris E; Rogers, Mary P; Owings, Amanda C; Petzelt, Barbara; Mitchell, Joycelynn; Harry, Harold; Williams, Theresa; Goldberg, Dena; Labuda, Damian; Smith, David Glenn; Cybulski, Jerome S; Malhi, Ripan S

2016-10-01

This study presents genetic data for nine Native American populations from northern North America. Analyses of genetic variation focus on the Pacific Northwest (PNW). Using mitochondrial, Y chromosomal, and autosomal DNA variants, we aimed to more closely address the relationships of geography and language with present genetic diversity among the regional PNW Native American populations. Patterns of genetic diversity exhibited by the three genetic systems were consistent with our hypotheses: genetic variation was more strongly explained by geographic proximity than by linguistic structure. Our findings were corroborated through a variety on analytic approaches, with the unrooted trees for the three genetic systems consistently separating inland from coastal PNW populations. Furthermore, analyses of molecular variance support the trends exhibited by the unrooted trees, with geographic partitioning of PNW populations (F CT = 19.43%, p = 0.010 ± 0.009) accounting for over twice as much of the observed genetic variation as linguistic partitioning of the same populations (F CT = 9.15%, p = 0.193 ± 0.013). These findings demonstrate a consensus with previous PNW population studies examining the relationships of genome-wide variation, mitochondrial haplogroup frequencies, and skeletal morphology with geography and language.

Clock gene evolution: seasonal timing, phylogenetic signal, or functional constraint?

PubMed

Krabbenhoft, Trevor J; Turner, Thomas F

2014-01-01

Genetic determinants of seasonal reproduction are not fully understood but may be important predictors of organism responses to climate change. We used a comparative approach to study the evolution of seasonal timing within a fish community in a natural common garden setting. We tested the hypothesis that allelic length variation in the PolyQ domain of a circadian rhythm gene, Clock1a, corresponded to interspecific differences in seasonal reproductive timing across 5 native and 1 introduced cyprinid fishes (n = 425 individuals) that co-occur in the Rio Grande, NM, USA. Most common allele lengths were longer in native species that initiated reproduction earlier (Spearman's r = -0.70, P = 0.23). Clock1a allele length exhibited strong phylogenetic signal and earlier spawners were evolutionarily derived. Aside from length variation in Clock1a, all other amino acids were identical across native species, suggesting functional constraint over evolutionary time. Interestingly, the endangered Rio Grande silvery minnow (Hybognathus amarus) exhibited less allelic variation in Clock1a and observed heterozygosity was 2- to 6-fold lower than the 5 other (nonimperiled) species. Reduced genetic variation in this functionally important gene may impede this species' capacity to respond to ongoing environmental change.

Exospheric hydrogen above St-Santin /France/

NASA Technical Reports Server (NTRS)

Derieux, A.; Lejeune, G.; Bauer, P.

1975-01-01

The temperature and hydrogen concentration of the exosphere was determined using incoherent scatter measurements performed above St. Santin from 1969 to 1972. The hydrogen concentration was deduced from measurements of the number density of positive hydrogen and oxygen ions. A statistical analysis is given of the hydrogen concentration as a function of the exospheric temperature and the diurnal variation of the hydrogen concentration is investigated for a few selected days of good quality observation. The data averaged with respect to the exospheric temperature without consideration of the local time exhibits a distribution consistent with a constant effective Jeans escape flux of about 9 x 10 to the 7 cu cm/s. The local time variation exhibits a maximum to minimum concentration ratio of at least 3.5.

Should policy-makers and managers trust PSI? An empirical validation study of five patient safety indicators in a national health service

PubMed Central

2012-01-01

Background Patient Safety Indicators (PSI) are being modestly used in Spain, somewhat due to concerns on their empirical properties. This paper provides evidence by answering three questions: a) Are PSI differences across hospitals systematic -rather than random?; b) Do PSI measure differences among hospital-providers -as opposed to differences among patients?; and, c) Are measurements able to detect hospitals with a higher than "expected" number of cases? Methods An empirical validation study on administrative data was carried out. All 2005 and 2006 publicly-funded hospital discharges were used to retrieve eligible cases of five PSI: Death in low-mortality DRGs (MLM); decubitus ulcer (DU); postoperative pulmonary embolism or deep-vein thrombosis (PE-DVT); catheter-related infections (CRI), and postoperative sepsis (PS). Empirical Bayes statistic (EB) was used to estimate whether the variation was systematic; logistic-multilevel modelling determined what proportion of the variation was explained by the hospital; and, shrunken residuals, as provided by multilevel modelling, were plotted to flag hospitals performing worse than expected. Results Variation across hospitals was observed to be systematic in all indicators, with EB values ranging from 0.19 (CI95%:0.12 to 0.28) in PE-DVT to 0.34 (CI95%:0.25 to 0.45) in DU. A significant proportion of the variance was explained by the hospital, once patient case-mix was adjusted: from a 6% in MLM (CI95%:3% to 11%) to a 24% (CI95%:20% to 30%) in CRI. All PSI were able to flag hospitals with rates over the expected, although this capacity decreased when the largest hospitals were analysed. Conclusion Five PSI showed reasonable empirical properties to screen healthcare performance in Spanish hospitals, particularly in the largest ones. PMID:22369291

CO2 Flux Estimation Errors Associated with Moist Atmospheric Processes

NASA Technical Reports Server (NTRS)

Parazoo, N. C.; Denning, A. S.; Kawa, S. R.; Pawson, S.; Lokupitiya, R.

2012-01-01

Vertical transport by moist sub-grid scale processes such as deep convection is a well-known source of uncertainty in CO2 source/sink inversion. However, a dynamical link between vertical transport, satellite based retrievals of column mole fractions of CO2, and source/sink inversion has not yet been established. By using the same offline transport model with meteorological fields from slightly different data assimilation systems, we examine sensitivity of frontal CO2 transport and retrieved fluxes to different parameterizations of sub-grid vertical transport. We find that frontal transport feeds off background vertical CO2 gradients, which are modulated by sub-grid vertical transport. The implication for source/sink estimation is two-fold. First, CO2 variations contained in moist poleward moving air masses are systematically different from variations in dry equatorward moving air. Moist poleward transport is hidden from orbital sensors on satellites, causing a sampling bias, which leads directly to small but systematic flux retrieval errors in northern mid-latitudes. Second, differences in the representation of moist sub-grid vertical transport in GEOS-4 and GEOS-5 meteorological fields cause differences in vertical gradients of CO2, which leads to systematic differences in moist poleward and dry equatorward CO2 transport and therefore the fraction of CO2 variations hidden in moist air from satellites. As a result, sampling biases are amplified and regional scale flux errors enhanced, most notably in Europe (0.43+/-0.35 PgC /yr). These results, cast from the perspective of moist frontal transport processes, support previous arguments that the vertical gradient of CO2 is a major source of uncertainty in source/sink inversion.

The ever-surprising blazar OJ 287: multi-wavelength study and appearance of a new component in X-rays

NASA Astrophysics Data System (ADS)

Kushwaha, Pankaj; Gupta, Alok C.; Wiita, Paul J.; Pal, Main; Gaur, Haritma; de Gouveia Dal Pino, E. M.; Kurtanidze, O. M.; Semkov, E.; Damljanovic, G.; Hu, S. M.; Uemura, M.; Vince, O.; Darriba, A.; Gu, M. F.; Bachev, R.; Chen, Xu; Itoh, R.; Kawabata, M.; Kurtanidze, S. O.; Nakaoka, T.; Nikolashvili, M. G.; Sigua, L. A.; Strigachev, A.; Zhang, Z.

2018-06-01

We present a multi-wavelength spectral and temporal investigation of OJ 287 emission during its strong optical-to-X-ray activity between July 2016 - July 2017. The daily γ-ray fluxes from Fermi-LAT are consistent with no variability. The strong optical-to-X-ray variability is accompanied by a change in power-law spectral index of the X-ray spectrum from <2 to >2, with variations often associated with changes in optical polarization properties. Cross-correlations between optical-to-X-ray emission during four continuous segments show simultaneous optical-ultraviolet (UV) variations while the X-ray and UV/optical are simultaneous only during the middle two segments. In the first segment, the results suggest X-rays lag the optical/UV, while in the last segment X-rays lead by ˜ 5-6 days. The last segment also shows a systematic trend with variations appearing first at higher energies followed by lower energy ones. The LAT spectrum before the VHE activity is similar to preceding quiescent state spectrum while it hardens during VHE activity period and is consistent with the extrapolated VHE spectrum during the latter. Overall, the broadband spectral energy distributions (SEDs) during high activity periods are a combination of a typical OJ 287 SED and an HBL SED, and can be explained in a two-zone leptonic model, with the second zone located at parsec scales, beyond the broad line region, being responsible for the HBL-like spectrum. The change of polarization properties from systematic to chaotic and back to systematic, before, during and after the VHE activity, suggest dynamic roles for magnetic fields and turbulence.

Defect chaos and bursts: hexagonal rotating convection and the complex Ginzburg-Landau equation.

PubMed

Madruga, Santiago; Riecke, Hermann; Pesch, Werner

2006-02-24

We employ numerical computations of the full Navier-Stokes equations to investigate non-Boussinesq convection in a rotating system using water as the working fluid. We identify two regimes. For weak non-Boussinesq effects the Hopf bifurcation from steady to oscillating (whirling) hexagons is supercritical and typical states exhibit defect chaos that is systematically described by the cubic complex Ginzburg-Landau equation. For stronger non-Boussinesq effects the Hopf bifurcation becomes subcritical and the oscillations exhibit localized chaotic bursting, which is modeled by a quintic complex Ginzburg-Landau equation.

Variation of clinical outcomes used in glaucoma randomised controlled trials: a systematic review.

PubMed

Ismail, Rehab; Azuara-Blanco, Augusto; Ramsay, Craig R

2014-04-01

In randomised clinical trials (RCTs) the selection of appropriate outcomes is crucial to the assessment of whether one intervention is better than another. The purpose of this review is to identify different clinical outcomes reported in glaucoma trials. We conducted a systematic review of glaucoma RCTs. A sample or selection of glaucoma trials were included bounded by a time frame (between 2006 and March 2012). Only studies in English language were considered. All clinical measured and reported outcomes were included. The possible variations of clinical outcomes were defined prior to data analysis. Information on reported clinical outcomes was tabulated and analysed using descriptive statistics. Other data recorded included type of intervention and glaucoma, duration of the study, defined primary outcomes, and outcomes used for sample size calculation, if nominated. The search strategy identified 4323 potentially relevant abstracts. There were 315 publications retrieved, of which 233 RCTs were included. A total of 967 clinical measures were reported. There were large variations in the definitions used to describe different outcomes and their measures. Intraocular pressure was the most commonly reported outcome (used in 201 RCTs, 86%) with a total of 422 measures (44%). Safety outcomes were commonly reported in 145 RCTs (62%) whereas visual field outcomes were used in 38 RCTs (16%). There is a large variation in the reporting of clinical outcomes in glaucoma RCTs. This lack of standardisation may impair the ability to evaluate the evidence of glaucoma interventions.

The temporal distribution of seismic radiation during deep earthquake rupture

USGS Publications Warehouse

Houston, H.; Vidale, J.E.

1994-01-01

The time history of energy release during earthquakes illuminates the process of failure, which remains enigmatic for events deeper than about 100 kilometers. Stacks of teleseismic records from regional arrays for 122 intermediate (depths of 100 to 350 kilometers) and deep (depths of 350 to 700 kilometers) earthquakes show that the temporal pattern of short-period seismic radiation has a systematic variation with depth. On average, for intermediate depth events more radiation is released toward the beginning of the rupture than near the end, whereas for deep events radiation is released symmetrically over the duration of the event, with an abrupt beginning and end of rupture. These findings suggest a variation in the style of rupture related to decreasing fault heterogeneity with depth.The time history of energy release during earthquakes illuminates the process of failure, which remains enigmatic for events deeper than about 100 kilometers. Stacks of teleseismic records from regional arrays for 122 intermediate (depths of 100 to 350 kilometers) and deep (depths of 350 to 700 kilometers) earthquakes show that the temporal pattern of short-period seismic radiation has a systematic variation with depth. On average, for intermediate depth events more radiation is released toward the beginning of the rupture than near the end, whereas for deep events radiation is released symmetrically over the duration of the event, with an abrupt beginning and end of rupture. These findings suggest a variation in the style of rupture related to decreasing fault heterogeneity with depth.

Quality of reporting of studies evaluating time to diagnosis: a systematic review in paediatrics.

PubMed

Launay, Elise; Morfouace, Michele; Deneux-Tharaux, Catherine; Gras le-Guen, Christèle; Ravaud, Philippe; Chalumeau, Martin

2014-03-01

An ever-increasing number of studies analyses the distribution, determinants and consequences of time to diagnosis and delays. Weaknesses in their reporting can impede the assessment of the risks of bias and variation and thus create a risk of invalid conclusions and counterproductive clinical and public health efforts. This study sought to assess systematically the quality of reporting of articles about time to diagnosis in paediatrics. Two authors identified and analysed the quality of reporting of 50 consecutive articles assessing these intervals published from 2005 through October 2011, according to a checklist we developed of 35 items potentially associated with risks of bias and variation. Frequency of articles reporting each item. Symptoms that should trigger a diagnostic procedure were reported in 28% of the articles; only two articles reported whether all patients with these symptoms underwent that procedure. Only 44% of the articles defined the beginning of the illness, 46% the date of diagnosis and 60% the distribution of time to diagnosis. Two studies met the criteria for all 11 items considered essential for assessing the risks of bias and variation in this type of study. This study identified many weaknesses in the quality of reporting of studies of time to diagnosis in paediatrics, especially for items potentially related to risks of bias and variation. This finding underlines the need for the development of new (or the refinement of existing) guidelines for reporting this type of study.

Subaru Telescope limits on cosmological variations in the fine-structure constant

NASA Astrophysics Data System (ADS)

Murphy, Michael T.; Cooksey, Kathy L.

2017-11-01

Previous, large samples of quasar absorption spectra have indicated some evidence for relative variations in the fine-structure constant (Δα/α) across the sky. However, they were likely affected by long-range distortions of the wavelength calibration, so it is important to establish a statistical sample of more reliable results from multiple telescopes. Here we triple the sample of Δα/α measurements from the Subaru Telescope which have been `supercalibrated' to correct for long-range distortions. A blinded analysis of the metallic ions in six intervening absorption systems in two Subaru quasar spectra provides no evidence for α variation, with a weighted mean of Δα/α = 3.0 ± 2.8stat ± 2.0sys parts per million (1σ statistical and systematic uncertainties). The main remaining systematic effects are uncertainties in the long-range distortion corrections, absorption profile models, and errors from redispersing multiple quasar exposures on to a common wavelength grid. The results also assume that terrestrial isotopic abundances prevail in the absorbers; assuming only the dominant terrestrial isotope is present significantly lowers Δα/α, though it is still consistent with zero. Given the location of the two quasars on the sky, our results do not support the evidence for spatial α variation, especially when combined with the 21 other recent measurements which were corrected for, or resistant to, long-range distortions. Our spectra and absorption profile fits are publicly available.

Quantifying the performance of in vivo portal dosimetry in detecting four types of treatment parameter variations

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bojechko, C.; Ford, E. C., E-mail: eford@uw.edu

Purpose: To quantify the ability of electronic portal imaging device (EPID) dosimetry used during treatment (in vivo) in detecting variations that can occur in the course of patient treatment. Methods: Images of transmitted radiation from in vivo EPID measurements were converted to a 2D planar dose at isocenter and compared to the treatment planning dose using a prototype software system. Using the treatment planning system (TPS), four different types of variability were modeled: overall dose scaling, shifting the positions of the multileaf collimator (MLC) leaves, shifting of the patient position, and changes in the patient body contour. The gamma passmore » rate was calculated for the modified and unmodified plans and used to construct a receiver operator characteristic (ROC) curve to assess the detectability of the different parameter variations. The detectability is given by the area under the ROC curve (AUC). The TPS was also used to calculate the impact of the variations on the target dose–volume histogram. Results: Nine intensity modulation radiation therapy plans were measured for four different anatomical sites consisting of 70 separate fields. Results show that in vivo EPID dosimetry was most sensitive to variations in the machine output, AUC = 0.70 − 0.94, changes in patient body habitus, AUC = 0.67 − 0.88, and systematic shifts in the MLC bank positions, AUC = 0.59 − 0.82. These deviations are expected to have a relatively small clinical impact [planning target volume (PTV) D{sub 99} change <7%]. Larger variations have even higher detectability. Displacements in the patient’s position and random variations in MLC leaf positions were not readily detectable, AUC < 0.64. The D{sub 99} of the PTV changed by up to 57% for the patient position shifts considered here. Conclusions: In vivo EPID dosimetry is able to detect relatively small variations in overall dose, systematic shifts of the MLC’s, and changes in the patient habitus. Shifts in the patient’s position which can introduce large changes in the target dose coverage were not readily detected.« less

Melt- rock reaction at oceanic peridotite-gabbro transition, through combined EBSD and in-situ mineral geochemistry on the Erro Tobbio peridotitic body (Ligurian ophiolites, Italy).

NASA Astrophysics Data System (ADS)

Basch, Valentin; Rampone, Elisabetta; Ildefonse, Benoit; Godard, Marguerite; Crispini, Laura

2017-04-01

Several lines of evidence have stressed that melt-rock reactions acting at the oceanic mantle-crust boundary play an important role in the chemical evolution of MORBs and the formation of the primitive (olivine-rich) lower oceanic crust. To address this issue, we performed detailed structural analyses and in-situ mineral geochemistry on the Erro-Tobbio (ET) ultramafic unit (Ligurian Alps, Italy), where impregnated mantle peridotites are primarily associated to a hectometre-size mafic body composed of troctolite to plagioclase-bearing wehrlite. The troctolitic body exhibits high complexity, with a host troctolite (Troctolite A) crosscut by troctolitic decametre-size pseudo-tabular bodies (Troctolite B). These different generations of troctolites show distinct modal compositions and textures. The host troctolite A displays a dominant millimetre-size corroded granular texture of olivine associated with dunite pods and a layering defined by poikilitic plagioclase enrichment. The contact between the mafic body and the host mantle peridotites is irregular, and defined by troctolite to wehrlite apophyses. The troctolite A shows microstructures and Crystallographic Preferred Orientation (CPO) indicative of a formation after impregnation of a mantle dunite by an olivine-undersaturated melt. This impregnation leads to olivine dissolution, associated with poikilitic plagioclase and clinopyroxene crystallization. This is indicated by a progressive randoming of the Axial-[100] CPO with olivine disaggregation and increasing melt input in the troctolite. The crosscutting troctolite B exhibits significant olivine textural variation, from fine-grained granular to deformed coarse-grained skeletal olivine. Olivine in the troctolite B shows CPO indicative of crystallization after magmatic flow, intrusive into the host troctolite A. Both troctolite types display large major and trace element variations in minerals, e.g. variation of Anorthite content (An = 54-67) in plagioclase at rather constant Forsterite content in olivine, and significant Zr, Ti, HREE heterogeneity in olivine, systematically correlated with the textural variability (e.g. corroded deformed vs. undeformed granular olivine). These features indicate that reactive crystallization had an important role in the origin of the ET troctolites. We infer that the textural heterogeneity of olivine in the troctolite B is related to variations in the degree of undercooling and cooling rate of the melt (Faure et al, 2003). The skeletal olivine crystallization could correspond to the influx of a more primitive melt into a colder host troctolite, followed by evolution of the melt leading to formation of fine-grained euhedral crystals. Overall, the results of this study suggest a poly-phase formation of this hectometre-scale gabbroic body, involving impregnation of a mantle-derived dunitic body followed by intrusion of undercooled primitive melts. Faure, F., Trolliard, G., Nicollet, C. & Montel, J.M. (2003), A developmental model of olivine morphology as a function of the cooling rate and the degree of undercooling. Contrib. Miner. Petrol. 145:251-263.

Evaluating variation in human gut microbiota profiles due to DNA extraction method and inter-subject differences.

PubMed

Wagner Mackenzie, Brett; Waite, David W; Taylor, Michael W

2015-01-01

The human gut contains dense and diverse microbial communities which have profound influences on human health. Gaining meaningful insights into these communities requires provision of high quality microbial nucleic acids from human fecal samples, as well as an understanding of the sources of variation and their impacts on the experimental model. We present here a systematic analysis of commonly used microbial DNA extraction methods, and identify significant sources of variation. Five extraction methods (Human Microbiome Project protocol, MoBio PowerSoil DNA Isolation Kit, QIAamp DNA Stool Mini Kit, ZR Fecal DNA MiniPrep, phenol:chloroform-based DNA isolation) were evaluated based on the following criteria: DNA yield, quality and integrity, and microbial community structure based on Illumina amplicon sequencing of the V4 region of bacterial and archaeal 16S rRNA genes. Our results indicate that the largest portion of variation within the model was attributed to differences between subjects (biological variation), with a smaller proportion of variation associated with DNA extraction method (technical variation) and intra-subject variation. A comprehensive understanding of the potential impact of technical variation on the human gut microbiota will help limit preventable bias, enabling more accurate diversity estimates.

Comments on the variational modified-hypernetted-chain theory for simple fluids

NASA Astrophysics Data System (ADS)

Rosenfeld, Yaakov

1986-02-01

The variational modified-hypernetted-chain (VMHNC) theory, based on the approximation of universality of the bridge functions, is reformulated. The new formulation includes recent calculations by Lado and by Lado, Foiles, and Ashcroft, as two stages in a systematic approach which is analyzed. A variational iterative procedure for solving the exact (diagrammatic) equations for the fluid structure which is formally identical to the VMHNC is described, featuring the theory of simple classical fluids as a one-iteration theory. An accurate method for calculating the pair structure for a given potential and for inverting structure factor data in order to obtain the potential and the thermodynamic functions, follows from our analysis.

How to calculate H3 better.

PubMed

Pavanello, Michele; Tung, Wei-Cheng; Adamowicz, Ludwik

2009-11-14

Efficient optimization of the basis set is key to achieving a very high accuracy in variational calculations of molecular systems employing basis functions that are explicitly dependent on the interelectron distances. In this work we present a method for a systematic enlargement of basis sets of explicitly correlated functions based on the iterative-complement-interaction approach developed by Nakatsuji [Phys. Rev. Lett. 93, 030403 (2004)]. We illustrate the performance of the method in the variational calculations of H(3) where we use explicitly correlated Gaussian functions with shifted centers. The total variational energy (-1.674 547 421 Hartree) and the binding energy (-15.74 cm(-1)) obtained in the calculation with 1000 Gaussians are the most accurate results to date.

The Rotational Excitation Temperature of the 6614 DIB Carrier

NASA Technical Reports Server (NTRS)

Cami, J.; Salama, F.; Jimenez-Vicente, J.; Galazutdinov, G.; Krelowski, J.

2004-01-01

Analysis of high spectral resolution observations of the lambda6614 DIB line profile show systematic variations in the positions of the peaks in the substructure of the profile. These variations can only be understood in the framework of rotational contours of large molecules, where the variations are caused by changes in the rotational excitation temperature. We show that the rotational excitation temperature for the DIB carrier is of the order 10-40 K - much lower than the gas kinetic temperature - indicating that for this particular DIB carrier angular momentum buildup is not very efficient. The rotational constant indicates that the carrier of this DIB is smaller than previously assumed:7-22 C atoms, depending on the geometry.

The Effect of Fuel Quality on Carbon Dioxide and Nitrogen Oxide Emissions, While Burning Biomass and RDF

NASA Astrophysics Data System (ADS)

Kalnacs, J.; Bendere, R.; Murasovs, A.; Arina, D.; Antipovs, A.; Kalnacs, A.; Sprince, L.

2018-02-01

The article analyses the variations in carbon dioxide emission factor depending on parameters characterising biomass and RDF (refuse-derived fuel). The influence of moisture, ash content, heat of combustion, carbon and nitrogen content on the amount of emission factors has been reviewed, by determining their average values. The options for the improvement of the fuel to result in reduced emissions of carbon dioxide and nitrogen oxide have been analysed. Systematic measurements of biomass parameters have been performed, by determining their average values, seasonal limits of variations in these parameters and their mutual relations. Typical average values of RDF parameters and limits of variations have been determined.

Understanding the organization of the amphibian egg cytoplasm - Gravitational force as a probe

NASA Technical Reports Server (NTRS)

Neff, Anton W.; Malacinski, George M.; Yokota, Hiroki; Wakahara, Masami

1992-01-01

A combination of hypergravity (centrifugation) and hypogravity (clinostat) studies have been carried out on amphibian (frog, Xenopus) eggs. The results reveal that the twinning caused by centrifugation exhibits substantial spawning to spawning variation. That variation can be attributed to the apparent viscosity of the egg's internal cytoplasm. Simulated hypogravity results in a relocation of the egg's third (horizontal) cleavage furrow, toward the equator. Substantial egg-to-egg variation is also observed in this 'cleavage effect'. For interpreting spaceflight data and for using G-forces as probes for understanding the egg's architecture the egg variation documented herein should be considered.

Glacial-interglacial cycles in detrital sediment supply to the Amundsen Sea: Implications for West Antarctic Ice Sheet dynamics during the Late Pleistocene

NASA Astrophysics Data System (ADS)

Simoes Pereira, P.; van de Flierdt, T.; Hillenbrand, C. D.; Hemming, S. R.; Kuhn, G.

2017-12-01

The West Antarctic Ice Sheet (WAIS) plays a key role in the global climate system and its collapse could contribute up to 4.3 m of sea-level rise. Mass loss of this marine-based ice sheet is largely caused by ocean-driven melting of ice shelves. This is confimed by modern observational data which show significant glacier thinning and retreat of grounding lines, particularly in the Amundsen Sea area. We here apply an integrated approach to determine provenance of marine sediments, which enables us to trace erosion of different bedrock lithologies, ultimately tied to the location of the eroding ice through time. We present provenance analysis on detrital Holocene seafloor sediments from the Amundsen Sea Embayment as well as from two marine cores PS58/254 (69°19´S, 108°27´W) and PC493 (71°09´S, 119°57´W), located on the continental rise of the Amundsen Sea and covering glacial-interglacial cycles of the past 800 kyrs. We use strontium (Sr) and neodymium (Nd) isotopic compositions of fine terrigenous grains (<63μm), and 40Ar/39Ar ages on ice-rafted (>150μm) hornblende and biotite grains. Our Holocene mapping results reveal drainage pathways with distinct signatures in the eastern and western Amundsen Sea Embayment. The western embayment records a homogenous provenance signature, pointing to a local source area in the hinterland, while the eastern embayment shows a range of compositions indicating erosion of the eastern coastal margin and a distinct, but unexposed source lithology under Pine Island Glacier and/or its drainage basin. Systematic isotope variations are detected between glacial and interglacial stages in both downcore records. Core PS58/254 exhibits a radiogenic fingerprint throughout the Late Pleistocene and systematic glacial-interglacial fluctuations in the order of three ɛNd units. They correlate with physical properties of the sediments (i.e. magnetic susceptibility) and trend towards lower values during interglacials, notably during Marine Isotope Stage (MIS) 5 and MIS 7. Core PC493 exhibits similar radiogenic Nd isotope composition, but a slightly reduced magnitude of glacial-interglacial changes. Detailed analysis of our results will offer a framework for interpreting sediment records from the area, including those from a recent MeBo expedition (PS104) and upcoming IODP expedition 379.

Melting mode and source lithology inferred from trace element systematic in historical olivine from Lanzarote, Canary Islands

NASA Astrophysics Data System (ADS)

Gómez-Ulla, Alejandra; Sigmarsson, Olgeir; Guðfinnsson, Guðmundur H.

2017-04-01

Trace element concentrations and ratios in olivine phenocrysts, such as fractionation-corrected Ni x (FeO/MgO) and Fe/Mn, have been shown useful as probes of pyroxenite derived component in mixtures of primary mantle melts (e.g. Sobolev et al., 2007). For instance, higher Ni and lower Mn and Ca contents are expected in partial melts of pyroxenite compared to those of lherzolite. We have measured trace element concentrations in olivine from 1730-1736 AD (Timanfaya) and 1824 AD eruptions in Lanzarote (Canary Islands), which erupted mafic and mantle nodule bearing magmas, ranging in composition from highly silica-undersaturated basanite through alkali basalt to tholeiite. The early basanite exhibit the largest olivine trace element variation covering the range of those from MORB and OIB worldwide, whereas later erupted tholeiite have values typical from pyroxenite derived melts. The Fo value decreased systematically with time during the 1730-36 eruption and the proportion of silica-saturated primary melt increased in the parental magma mixture with time. At the end of the eruption, tholeiite magmas crystallized olivine with, increasing concentrations of Mn and Ca and higher Ca/Al at relatively uniform Ni x (FeO/MgO) and Fe/Mn, all of which is readily explained by increased decompression melting at lower temperature. The basanite from the eruption that took place in 1824 AD has olivine with even higher Fo value and trace element variability similar those of the Timanfaya basanite. The fact that the Lanzarote basanite contain olivine with trace element systematic spanning that of MORB and pyroxenite melt can be explained by CO2-flux melting of a lithologically heterogeneous source, generating the diverse compositions. Initial reactive porous flow through depleted oceanic lithosphere and equilibration with dunitic restite of percolating pyroxenite melt may have amplified the observed Ni depletion in olivine of the earliest basanite. The fact that olivine compositions and basanite magma were reproduced approximately a century later may reflect episodic carbonatic fluxing in the slowly uprising Canarian mantle plume.

All-Polymer Solar Cell Performance Optimized via Systematic Molecular Weight Tuning of Both Donor and Acceptor Polymers

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhou, Nanjia; Dudnik, Alexander S.; Li, Ting I. N. G.

2015-12-31

ABSTRACT: The influence of the number-average molecular weight (Mn) on the blend film morphology and photovoltaic performance of all-polymer solar cells (APSCs) fabricated with the donor polymer poly[5-(2-hexyldodecyl)-1,3-thieno[3,4- c]pyrrole-4,6-dione-alt-5,5-(2,5-bis(3-dodecylthiophen-2-yl)- thiophene)] (PTPD3T) and acceptor polymer poly{[N,N'- bis(2-octyldodecyl)naphthalene-1,4,5,8-bis(dicarboximide)- 2,6-diyl]-alt-5,5'-(2,2'-bithiophene)} (P(NDI2OD-T2); N2200) is systematically investigated. The M n effect analysis of both PTPD3T and N2200 is enabled by implementing a polymerization strategy which produces conjugated polymers with tunable M ns. Experimental and coarse-grain modeling results reveal that systematic M n variation greatly influences both intrachain and interchain interactions and ultimately the degree of phase separation and morphology evolution. Specifically, increasing M n formore » both polymers shrinks blend film domain sizes and enhances donor-acceptor polymer-polymer interfacial areas, affording increased short-circuit current densities (J sc). However, the greater disorder and intermixed feature proliferation accompanying increasing M n promotes charge carrier recombination, reducing cell fill factors (FF). The optimized photoactive layers exhibit well-balanced exciton dissociation and charge transport characteristics, ultimately providing solar cells with a 2-fold PCE enhancement versus devices with nonoptimal M ns. Overall, it is shown that proper and precise tuning of both donor and acceptor polymer M ns is critical for optimizing APSC performance. In contrast to reports where maximum power conversion efficiencies (PCEs) are achieved for the highest M ns, the present two-dimensional M n optimization matrix strategy locates a PCE “sweet spot” at intermediate Mns of both donor and acceptor polymers. This study provides synthetic methodologies to predictably access conjugated polymers with desired M n and highlights the importance of optimizing M n for both polymer components to realize the full potential of APSC performance.« less

Inter-Ethnic/Racial Facial Variations: A Systematic Review and Bayesian Meta-Analysis of Photogrammetric Studies

PubMed Central

Wen, Yi Feng; Wong, Hai Ming; Lin, Ruitao; Yin, Guosheng; McGrath, Colman

2015-01-01

Background Numerous facial photogrammetric studies have been published around the world. We aimed to critically review these studies so as to establish population norms for various angular and linear facial measurements; and to determine inter-ethnic/racial facial variations. Methods and Findings A comprehensive and systematic search of PubMed, ISI Web of Science, Embase, and Scopus was conducted to identify facial photogrammetric studies published before December, 2014. Subjects of eligible studies were either Africans, Asians or Caucasians. A Bayesian hierarchical random effects model was developed to estimate posterior means and 95% credible intervals (CrI) for each measurement by ethnicity/race. Linear contrasts were constructed to explore inter-ethnic/racial facial variations. We identified 38 eligible studies reporting 11 angular and 18 linear facial measurements. Risk of bias of the studies ranged from 0.06 to 0.66. At the significance level of 0.05, African males were found to have smaller nasofrontal angle (posterior mean difference: 8.1°, 95% CrI: 2.2°–13.5°) compared to Caucasian males and larger nasofacial angle (7.4°, 0.1°–13.2°) compared to Asian males. Nasolabial angle was more obtuse in Caucasian females than in African (17.4°, 0.2°–35.3°) and Asian (9.1°, 0.4°–17.3°) females. Additional inter-ethnic/racial variations were revealed when the level of statistical significance was set at 0.10. Conclusions A comprehensive database for angular and linear facial measurements was established from existing studies using the statistical model and inter-ethnic/racial variations of facial features were observed. The results have implications for clinical practice and highlight the need and value for high quality photogrammetric studies. PMID:26247212

Inter-Ethnic/Racial Facial Variations: A Systematic Review and Bayesian Meta-Analysis of Photogrammetric Studies.

PubMed

Wen, Yi Feng; Wong, Hai Ming; Lin, Ruitao; Yin, Guosheng; McGrath, Colman

2015-01-01

Numerous facial photogrammetric studies have been published around the world. We aimed to critically review these studies so as to establish population norms for various angular and linear facial measurements; and to determine inter-ethnic/racial facial variations. A comprehensive and systematic search of PubMed, ISI Web of Science, Embase, and Scopus was conducted to identify facial photogrammetric studies published before December, 2014. Subjects of eligible studies were either Africans, Asians or Caucasians. A Bayesian hierarchical random effects model was developed to estimate posterior means and 95% credible intervals (CrI) for each measurement by ethnicity/race. Linear contrasts were constructed to explore inter-ethnic/racial facial variations. We identified 38 eligible studies reporting 11 angular and 18 linear facial measurements. Risk of bias of the studies ranged from 0.06 to 0.66. At the significance level of 0.05, African males were found to have smaller nasofrontal angle (posterior mean difference: 8.1°, 95% CrI: 2.2°-13.5°) compared to Caucasian males and larger nasofacial angle (7.4°, 0.1°-13.2°) compared to Asian males. Nasolabial angle was more obtuse in Caucasian females than in African (17.4°, 0.2°-35.3°) and Asian (9.1°, 0.4°-17.3°) females. Additional inter-ethnic/racial variations were revealed when the level of statistical significance was set at 0.10. A comprehensive database for angular and linear facial measurements was established from existing studies using the statistical model and inter-ethnic/racial variations of facial features were observed. The results have implications for clinical practice and highlight the need and value for high quality photogrammetric studies.

Detecting measurement outliers: remeasure efficiently

NASA Astrophysics Data System (ADS)

Ullrich, Albrecht

2010-09-01

Shrinking structures, advanced optical proximity correction (OPC) and complex measurement strategies continually challenge critical dimension (CD) metrology tools and recipe creation processes. One important quality ensuring task is the control of measurement outlier behavior. Outliers could trigger false positive alarm for specification violations impacting cycle time or potentially yield. Constant high level of outliers not only deteriorates cycle time but also puts unnecessary stress on tool operators leading eventually to human errors. At tool level the sources of outliers are natural variations (e.g. beam current etc.), drifts, contrast conditions, focus determination or pattern recognition issues, etc. Some of these can result from suboptimal or even wrong recipe settings, like focus position or measurement box size. Such outliers, created by an automatic recipe creation process faced with more complicated structures, would manifest itself rather as systematic variation of measurements than the one caused by 'pure' tool variation. I analyzed several statistical methods to detect outliers. These range from classical outlier tests for extrema, robust metrics like interquartile range (IQR) to methods evaluating the distribution of different populations of measurement sites, like the Cochran test. The latter suits especially the detection of systematic effects. The next level of outlier detection entwines additional information about the mask and the manufacturing process with the measurement results. The methods were reviewed for measured variations assumed to be normally distributed with zero mean but also for the presence of a statistically significant spatial process signature. I arrive at the conclusion that intelligent outlier detection can influence the efficiency and cycle time of CD metrology greatly. In combination with process information like target, typical platform variation and signature, one can tailor the detection to the needs of the photomask at hand. By monitoring the outlier behavior carefully, weaknesses of the automatic recipe creation process can be spotted.

Genetics in endocrinology: genetic variation in deiodinases: a systematic review of potential clinical effects in humans.

PubMed

Verloop, Herman; Dekkers, Olaf M; Peeters, Robin P; Schoones, Jan W; Smit, Johannes W A

2014-09-01

Iodothyronine deiodinases represent a family of selenoproteins involved in peripheral and local homeostasis of thyroid hormone action. Deiodinases are expressed in multiple organs and thyroid hormone affects numerous biological systems, thus genetic variation in deiodinases may affect multiple clinical endpoints. Interest in clinical effects of genetic variation in deiodinases has clearly increased. We aimed to provide an overview for the role of deiodinase polymorphisms in human physiology and morbidity. In this systematic review, studies evaluating the relationship between deiodinase polymorphisms and clinical parameters in humans were eligible. No restrictions on publication date were imposed. The following databases were searched up to August 2013: Pubmed, EMBASE (OVID-version), Web of Science, COCHRANE Library, CINAHL (EbscoHOST-version), Academic Search Premier (EbscoHOST-version), and ScienceDirect. Deiodinase physiology at molecular and tissue level is described, and finally the role of these polymorphisms in pathophysiological conditions is reviewed. Deiodinase type 1 (D1) polymorphisms particularly show moderate-to-strong relationships with thyroid hormone parameters, IGF1 production, and risk for depression. D2 variants correlate with thyroid hormone levels, insulin resistance, bipolar mood disorder, psychological well-being, mental retardation, hypertension, and risk for osteoarthritis. D3 polymorphisms showed no relationship with inter-individual variation in serum thyroid hormone parameters. One D3 polymorphism was associated with risk for osteoarthritis. Genetic deiodinase profiles only explain a small proportion of inter-individual variations in serum thyroid hormone levels. Evidence suggests a role of genetic deiodinase variants in certain pathophysiological conditions. The value for determination of deiodinase polymorphism in clinical practice needs further investigation. © 2014 European Society of Endocrinology.

Semi-automated confocal imaging of fungal pathogenesis on plants: microscopic analysis of macroscopic specimens

USDA-ARS?s Scientific Manuscript database

Contextualizing natural genetic variation in plant disease resistance in terms of pathogenesis can provide information about the function of causal genes. Cellular mechanisms associated with pathogenesis can be elucidated with confocal microscopy, but systematic phenotyping platforms—from sample pro...

Crank case scavenging of a two-stroke-cycle engine

NASA Technical Reports Server (NTRS)

Holm, Otto

1928-01-01

Experiments with a two-stroke-cycle, crank case scavenging engine. Effect of systematic variation of the height of the scavenge and exhaust ports on the scavenging, as determined by gas analysis. The best results were obtained under conditions differing from the usual ones.

On the correlations between the polyhedron eccentricity parameters and the bond-valence sums for the cations with one lone electron pair. Addendum.

PubMed

Sidey, Vasyl

2009-06-01

Systematic variations of the bond-valence sums calculated from the poorly determined bond-valence parameters [Sidey (2008), Acta Cryst. B64, 515-518] have been illustrated using a simple graphical scheme.

Relaxation Training and Covert Positive Reinforcement with Elementary School Children.

ERIC Educational Resources Information Center

Vacc, Nicholas A.; Greenleaf, Susan M.

1980-01-01

Variations of systematic desensitization that include deep muscle relaxation (DMR) seem useful in remediating some behavior problems of children. Studied the effects of DMR and DMR with Covert Positive Reinforcement (CPR) in reducing maladaptive behavior of children, ages 6 to 12. (Author)

Pre-analytic and analytic sources of variations in thiopurine methyltransferase activity measurement in patients prescribed thiopurine-based drugs: A systematic review.

PubMed

Loit, Evelin; Tricco, Andrea C; Tsouros, Sophia; Sears, Margaret; Ansari, Mohammed T; Booth, Ronald A

2011-07-01

Low thiopurine S-methyltransferase (TPMT) enzyme activity is associated with increased thiopurine drug toxicity, particularly myelotoxicity. Pre-analytic and analytic variables for TPMT genotype and phenotype (enzyme activity) testing were reviewed. A systematic literature review was performed, and diagnostic laboratories were surveyed. Thirty-five studies reported relevant data for pre-analytic variables (patient age, gender, race, hematocrit, co-morbidity, co-administered drugs and specimen stability) and thirty-three for analytic variables (accuracy, reproducibility). TPMT is stable in blood when stored for up to 7 days at room temperature, and 3 months at -30°C. Pre-analytic patient variables do not affect TPMT activity. Fifteen drugs studied to date exerted no clinically significant effects in vivo. Enzymatic assay is the preferred technique. Radiochemical and HPLC techniques had intra- and inter-assay coefficients of variation (CVs) below 10%. TPMT is a stable enzyme, and its assay is not affected by age, gender, race or co-morbidity. Copyright © 2011. Published by Elsevier Inc.

Near-infrared spectral reflectance of mineral mixtures - Systematic combinations of pyroxenes, olivine, and iron oxides

NASA Technical Reports Server (NTRS)

Singer, R. B.

1981-01-01

Near-infrared spectral reflectance data are presented for systematic variations in weight percent of two component mixtures of ferromagnesium and iron oxide minerals used to study the dark materials on Mars. Olivine spectral features are greatly reduced in contrast by admixture of other phases but remain distinctive even for low olivine contents. Clinopyroxene and orthopyroxene mixtures show resolved pyroxene absorptions near 2 microns. Limonite greatly modifies pyroxene and olivine reflectance, but does not fully eliminate distinctive spectral characteristics. Using only spectral data in the 1 micron region, it is difficult to differentiate orthopyroxene and limonite in a mixture. All composite mineral absorptions were either weaker than or intermediate in strength to the end-member absorptions and have bandwidths greater than or equal to those for the end members. In general, spectral properties in an intimate mixture combine in a complex, nonadditive manner, with features demonstrating a regular but usually nonlinear variation as a function of end-member phase proportions.

X-ray photoemission analysis of clean and carbon monoxide-chemisorbed platinum(111) stepped surfaces using a curved crystal

DOE PAGES

Walter, Andrew L.; Schiller, Frederik; Corso, Martina; ...

2015-11-12

Surface chemistry and catalysis studies could significantly gain from the systematic variation of surface active sites, tested under the very same conditions. Curved crystals are excellent platforms to perform such systematics, which may in turn allow to better resolve fundamental properties and reveal new phenomena. This is demonstrated here for the carbon monoxide/platinum system. We curve a platinum crystal around the high-symmetry (111) direction and carry out photoemission scans on top. This renders the spatial core-level imaging of carbon monoxide adsorbed on a 'tunable' vicinal surface, allowing a straightforward visualization of the rich chemisorption phenomenology at steps and terraces. Throughmore » such photoemission images we probe a characteristic elastic strain variation at stepped surfaces, and unveil subtle stress-release effects on clean and covered vicinal surfaces. Lastly, these results offer the prospect of applying the curved surface approach to rationally investigate the chemical activity of surfaces under real pressure conditions.« less

Systematic control of optical features in aluminosilicate glass waveguides using direct femtosecond laser writing

NASA Astrophysics Data System (ADS)

Babu, B. Hari; Niu, Mengsi; Yang, Xiaoyu; Wang, Yanbo; Feng, Lin; Qin, Wei; Hao, Xiao-Tao

2017-10-01

Low loss optical waveguides inside aluminosilicate glasses have been successfully fabricated using direct femtosecond laser writing. To establish the influence of pulse energy and host variations on the optical waveguides have been tentatively explored and systematically studied with the help of different spectroscopic techniques. Isochronal annealing treatment effectively reduces the insertion losses to 1.01 ± 0.28 dB at 632.8 nm. A red shift of the Raman band has been observed with increasing Al2O3 content due to the bond angle variations. The point defects such as non-bridging oxygen hole centers have been corroborated by the photoluminescence studies and significant red-shift has also been documented with increasing Al2O3 content. In addition, there is no NBOHC defects perceived after isochronal annealing treatment inside the glass waveguides. Our results envisage that the present glass waveguides should be promising and potential for applications in passive waveguides and integrated photonic devices.

X-ray photoemission analysis of clean and carbon monoxide-chemisorbed platinum(111) stepped surfaces using a curved crystal

DOE Office of Scientific and Technical Information (OSTI.GOV)

Walter, Andrew L.; Schiller, Frederik; Corso, Martina

Surface chemistry and catalysis studies could significantly gain from the systematic variation of surface active sites, tested under the very same conditions. Curved crystals are excellent platforms to perform such systematics, which may in turn allow to better resolve fundamental properties and reveal new phenomena. This is demonstrated here for the carbon monoxide/platinum system. We curve a platinum crystal around the high-symmetry (111) direction and carry out photoemission scans on top. This renders the spatial core-level imaging of carbon monoxide adsorbed on a 'tunable' vicinal surface, allowing a straightforward visualization of the rich chemisorption phenomenology at steps and terraces. Throughmore » such photoemission images we probe a characteristic elastic strain variation at stepped surfaces, and unveil subtle stress-release effects on clean and covered vicinal surfaces. Lastly, these results offer the prospect of applying the curved surface approach to rationally investigate the chemical activity of surfaces under real pressure conditions.« less

Prevalence of sleep bruxism in children: A systematic review

PubMed Central

Machado, Eduardo; Dal-Fabbro, Cibele; Cunali, Paulo Afonso; Kaizer, Osvaldo Bazzan

2014-01-01

INTRODUCTION: Prevalence of sleep bruxism (SB) in children is subject to discussions in the literature. OBJECTIVE: This study is a systematic literature review aiming to critically assess the prevalence of SB in children. METHODS: Survey using the following research databases: MEDLINE, Cochrane, EMBASE, PubMed, Lilacs and BBO, from January 2000 to February 2013, focusing on studies specifically assessing the prevalence of SB in children. RESULTS: After applying the inclusion criteria, four studies were retrieved. Among the selected articles, the prevalence rates of SB ranged from 5.9% to 49.6%, and these variations showed possible associations with the diagnostic criteria used for SB. CONCLUSION: There is a small number of studies with the primary objective of assessing SB in children. Additionally, there was a wide variation in the prevalence of SB in children. Thus, further, evidence-based studies with standardized and validated diagnostic criteria are necessary to assess the prevalence of SB in children more accurately. PMID:25628080

Genetic variation for pseudo-self-compatibility in self-incompatible populations of Leavenworthia alabamica (Brassicaceae).

PubMed

Baldwin, Sarah J; Schoen, Daniel J

2017-01-01

Self-incompatibility (SI) promotes outcrossing, but transitions to self-compatibility (SC) are frequent. Population genetic theory describing the breakdown of SI to SC suggests that, under most conditions, populations should be composed of either SI or SC individuals. Under a narrow range of conditions, theory suggests that SI may persist alongside reduced expression of SI (pseudo-SI, PSI) in mixed-mating populations. We studied genetic variation for PSI segregating in four SI populations of Leavenworthia alabamica by measurement of the heritability of pollen tube number after self-pollination. We tested for the role of the S-locus in this variation by sequencing seven S-alleles from plants with high pseudo-SC (PSC) and testing for the co-segregation of these alleles with PSC. We found a continuous distribution of PSC in all populations and 90% of plants exhibited PSC. The heritability ranged from 0.39 to 0.57. All seven S-alleles from plants with high PSC exhibited trans-specific polymorphism, and no stop codons were observed within the c. 600-bp region sequenced. One of these S-alleles was directly associated with the inheritance of PSC. We conclude that heritable variation in PSC is largely a result of genetic variation in the signaling cascade downstream of the S-locus reaction, together with the presence of one leaky S-allele. © 2016 The Authors. New Phytologist © 2016 New Phytologist Trust.

Statistical Analyses of Satellite Cloud Object Data From CERES. Part 4; Boundary-layer Cloud Objects During 1998 El Nino

NASA Technical Reports Server (NTRS)

Xu, Kuan-Man; Wong, Takmeng; Wielicki, Bruce A.; Parker, Lindsay

2006-01-01

Three boundary-layer cloud object types, stratus, stratocumulus and cumulus, that occurred over the Pacific Ocean during January-August 1998, are identified from the CERES (Clouds and the Earth s Radiant Energy System) single scanner footprint (SSF) data from the TRMM (Tropical Rainfall Measuring Mission) satellite. This study emphasizes the differences and similarities in the characteristics of each cloud-object type between the tropical and subtropical regions and among different size categories and among small geographic areas. Both the frequencies of occurrence and statistical distributions of cloud physical properties are analyzed. In terms of frequencies of occurrence, stratocumulus clouds dominate the entire boundary layer cloud population in all regions and among all size categories. Stratus clouds are more prevalent in the subtropics and near the coastal regions, while cumulus clouds are relatively prevalent over open ocean and the equatorial regions, particularly, within the small size categories. The largest size category of stratus cloud objects occurs more frequently in the subtropics than in the tropics and has much larger average size than its cumulus and stratocumulus counterparts. Each of the three cloud object types exhibits small differences in statistical distributions of cloud optical depth, liquid water path, TOA albedo and perhaps cloud-top height, but large differences in those of cloud-top temperature and OLR between the tropics and subtropics. Differences in the sea surface temperature (SST) distributions between the tropics and subtropics influence some of the cloud macrophysical properties, but cloud microphysical properties and albedo for each cloud object type are likely determined by (local) boundary-layer dynamics and structures. Systematic variations of cloud optical depth, TOA albedo, cloud-top height, OLR and SST with cloud object sizes are pronounced for the stratocumulus and stratus types, which are related to systematic variations of the strength of inversion with cloud object sizes, produced by large-scale subsidence. The differences in cloud macrophysical properties over small regions are significantly larger than those of cloud microphysical properties and TOA albedo, suggesting a greater control of (local) large-scale dynamics and other factors on cloud object properties. When the three cloud object types are combined, the relative population among the three types is the most important factor for determining the cloud object properties in a Pacific transect where the transition of boundary-layer cloud types takes place.

Poster exhibitions at conferences: are we doing it properly?

PubMed

Beamish, Andrew J; Ansell, James; Foster, Jessica J; Foster, Kathryn A; Egan, Richard J

2015-01-01

Literature exploring the educational value and quality of conference poster presentation is scarce. The aim of this study was to identify and describe the variation in poster exhibitions across a spectrum of conferences attended by trainees. Prospective observational assessment of conference posters was carried out across 7 variables at 4 conferences attended by surgical trainees in 2012. Posters were compared by individual variables and according to overall poster score combining all 7 variables examined. The number of authors listed was also compared. Random samples of consecutively numbered posters were examined at the exhibitions of 4 conferences, which included a UK national medical education conference (Association for the Study of Medical Education), a UK international surgical conference (Association of Surgeons of Great Britain and Ireland), a European oncology conference (European Society of Surgical Oncology), and a North American joint medical and surgical conference (Digestive Diseases Week). Significant variation existed between conferences in posters and their presentation. The proportion of presenters failing to display their posters ranged from 3% to 26% (p < 0.0001). Adherence to size guidelines varied from 89% to 100% (p = 0.002). The inclusion of references ranged from 19% to 82% (p < 0.0001). The presence of a presenting author during the allocated session varied widely from 21% to 86% (p < 0.0001). No significant variation was observed in the proportion of posters that were formatted using aims, methods, results, and conclusion sections (81%-93%; p = 0.513) or in the proportion of posters that were identified as difficult to read (24%-28%; p = 0.919). Association for the Study of Medical Education outperformed each of the other exhibitions overall (p < 0.0001). Posters with greater than the median of 4 authors performed significantly better across all areas (p < 0.0001-0.042) except presenter attendance (p = 0.480). Poster exhibitions varied widely, with room for improvement at all 4 conferences. Lessons can be learned by all conferences from each other to improve presenter engagement with and the educational value of poster exhibitions. Copyright © 2014 Association of Program Directors in Surgery. Published by Elsevier Inc. All rights reserved.

Indications of a spatial variation of the fine structure constant.

PubMed

Webb, J K; King, J A; Murphy, M T; Flambaum, V V; Carswell, R F; Bainbridge, M B

2011-11-04

We previously reported Keck telescope observations suggesting a smaller value of the fine structure constant α at high redshift. New Very Large Telescope (VLT) data, probing a different direction in the Universe, shows an inverse evolution; α increases at high redshift. Although the pattern could be due to as yet undetected systematic effects, with the systematics as presently understood the combined data set fits a spatial dipole, significant at the 4.2 σ level, in the direction right ascension 17.5 ± 0.9 h, declination -58 ± 9 deg. The independent VLT and Keck samples give consistent dipole directions and amplitudes, as do high and low redshift samples. A search for systematics, using observations duplicated at both telescopes, reveals none so far which emulate this result.

The association between ambient temperature and childhood asthma: a systematic review

NASA Astrophysics Data System (ADS)

Xu, Zhiwei; Crooks, James Lewis; Davies, Janet Mary; Khan, Al Fazal; Hu, Wenbiao; Tong, Shilu

2018-03-01

The objectives of this study are to review available information on the association between ambient temperature and childhood asthma, and to elucidate the possible underlying mechanisms of this relationship. A systematic review was conducted based on the papers retrieved from four databases, including PubMed, ProQuest, ScienceDirect, and Scopus. Papers examining the association of absolute temperature or temperature variation with childhood asthma published from 1 January 2000 to 31 December 2016 were included. Thirteen papers have quantified the effect of absolute temperature on childhood asthma, and six papers have examined the effect of intra- or inter-day temperature variation on childhood asthma. All studies were conducted in urban areas. Aeroallergen sensitizations were only considered in the analyses of one study. Discrepancy existed in the significance of the relationship between absolute temperature and childhood asthma, and also in the shape of this relationship (i.e. linear or non-linear) and whether temperature effects were lagged. Increasing evidence is suggesting non-linear relationship between absolute temperature and childhood asthma. Future research should investigate the burden of childhood asthma specifically attributable to extreme temperatures and temperature variation using advanced statistical approach, particularly in rural areas, after properly considering aeroallergens and air pollution. Projecting future burden of childhood asthma under climate change scenarios is also warranted.

The association between ambient temperature and childhood asthma: a systematic review.

PubMed

Xu, Zhiwei; Crooks, James Lewis; Davies, Janet Mary; Khan, Al Fazal; Hu, Wenbiao; Tong, Shilu

2018-03-01

The objectives of this study are to review available information on the association between ambient temperature and childhood asthma, and to elucidate the possible underlying mechanisms of this relationship. A systematic review was conducted based on the papers retrieved from four databases, including PubMed, ProQuest, ScienceDirect, and Scopus. Papers examining the association of absolute temperature or temperature variation with childhood asthma published from 1 January 2000 to 31 December 2016 were included. Thirteen papers have quantified the effect of absolute temperature on childhood asthma, and six papers have examined the effect of intra- or inter-day temperature variation on childhood asthma. All studies were conducted in urban areas. Aeroallergen sensitizations were only considered in the analyses of one study. Discrepancy existed in the significance of the relationship between absolute temperature and childhood asthma, and also in the shape of this relationship (i.e. linear or non-linear) and whether temperature effects were lagged. Increasing evidence is suggesting non-linear relationship between absolute temperature and childhood asthma. Future research should investigate the burden of childhood asthma specifically attributable to extreme temperatures and temperature variation using advanced statistical approach, particularly in rural areas, after properly considering aeroallergens and air pollution. Projecting future burden of childhood asthma under climate change scenarios is also warranted.

Relevance of Variations in the Opposing Dentition for the Functionality of Fixed and Removable Partial Dentures: A Systematic Review

PubMed Central

Pommer, Bernhard; Krainhöfner, Martin; Watzek, Georg; Tepper, Gabor; Dintsios, Charalabos-Markos

2012-01-01

The aim of this systematic review was to evaluate the functionality of fixed and removable partial dentures as test interventions in relation to variations in the opposing dentition and their prosthetic restoration. The abstracts identified in the respective databases were screened independently by two investigators. RCTs and uncontrolled studies were considered, provided the patients were included consecutively and the confounding variables were adequately monitored. Seventeen papers were included. The study and publication quality was assessed using a “biometric quality” tool showing an overall poor quality. The reported outcomes, such as survival rates, were in each case obtained from a single study. Two possible trends could be deduced for the endpoint longevity: (a) the first trend in favor of removable partial dentures, compared to fixed partial dentures, with a fully edentulous opposing arch fitted with a removable prosthesis; (b) the second trend in favor of implant-supported partial dentures, compared to conventionally fixed partial dentures, with natural opposing dentition or with a removable partial denture in the opposing arch. No evidence could be generated as to whether, and if so how, variations in the opposing dentition have a bearing on the decision to fit a partially edentulous arch with a fixed or removable partial denture. PMID:23193407

Long-term Variations of The Solar Activity -- Lower Atmosphere Relationship

NASA Astrophysics Data System (ADS)

Zaitseva, S.; Akhremtchik, S.; Pudovkin, M.; Besser, B.; Rijnbeek, R.

Long-term variations of the air temperature in St.Petersburg, Stockholm, Salzburg and English Midlands are considered. There is shown that in the regions under consider- ation the air temperature distinctly depends on the intensity of the lower atmospheric zonal circulation (Blinova index and North Atlantic Oscillation index (NAO)). In turn, the NAO-index is shown to depend on the solar activity. However, this dependence is rather complicated and exhibits long-period variations associated with secular varia- tions of the solar activity. A possible mechanism of this phenomena is discussed.

Qualitative reasoning for biological network inference from systematic perturbation experiments.

PubMed

Badaloni, Silvana; Di Camillo, Barbara; Sambo, Francesco

2012-01-01

The systematic perturbation of the components of a biological system has been proven among the most informative experimental setups for the identification of causal relations between the components. In this paper, we present Systematic Perturbation-Qualitative Reasoning (SPQR), a novel Qualitative Reasoning approach to automate the interpretation of the results of systematic perturbation experiments. Our method is based on a qualitative abstraction of the experimental data: for each perturbation experiment, measured values of the observed variables are modeled as lower, equal or higher than the measurements in the wild type condition, when no perturbation is applied. The algorithm exploits a set of IF-THEN rules to infer causal relations between the variables, analyzing the patterns of propagation of the perturbation signals through the biological network, and is specifically designed to minimize the rate of false positives among the inferred relations. Tested on both simulated and real perturbation data, SPQR indeed exhibits a significantly higher precision than the state of the art.

An examination of extratropical cyclone response to changes in baroclinicity and temperature in an idealized environment

NASA Astrophysics Data System (ADS)

Tierney, Gregory; Posselt, Derek J.; Booth, James F.

2018-02-01

The dynamics and precipitation in extratropical cyclones (ETCs) are known to be sensitive to changes in the cyclone environment, with increases in bulk water vapor and baroclinicity both leading to increases in storm strength and precipitation. Studies that demonstrate this sensitivity have commonly varied either the cyclone moisture or baroclinicity, but seldom both. In a changing climate, in which the near-surface equator to pole temperature gradient may weaken while the bulk water vapor content of the atmosphere increases, it is important to understand the relative response of ETC strength and precipitation to changes in both factors simultaneously. In this study, idealized simulations of ETC development are conducted in a moist environment using a model with a full suite of moist physics parameterizations. The bulk temperature (and water vapor content) and baroclinicity are systematically varied one at a time, then simultaneously, and the effect of these variations on the storm strength and precipitation is assessed. ETC intensity exhibits the well-documented response to changes in baroclinicity, with stronger ETCs forming in higher baroclinicity environments. However, increasing water vapor content produces non-monotonic changes in storm strength, in which storm intensity first increases with increasing environmental water vapor, then decreases above a threshold value. Examination of the storm geographic extent indicates cyclone size also decreases above a threshold value of bulk environmental temperature (and water vapor). Decrease in storm size is concomitant with an increase in the convective fraction of precipitation and a shift in the vertical distribution of latent heating. The results indicate the existence of at least two regimes for ETC development, each of which exhibit significantly different distributions of PV due to differences in timing and location of convective heating.

STXM/C 1s-NEXAFS study of Eu(III) and Uranyl humic acid aggregates at different pH

NASA Astrophysics Data System (ADS)

Plaschke, M.; Rothe, J.; Denecke, M. A.; Geckeis, H.

2010-04-01

Humic acids (HA) are chemically heterogeneous and structurally ill-defined biopolymers which are able to bind traces of actinides or lanthanides. Due to their dimensions in the colloidal size range they may affect transport of these elements in aquatic systems. Eu(III)- and UO22+-HA aggregates have been investigated by Scanning Transmission X-ray Microscopy (STXM) and C 1s-NEXAFS under systematic variation of pH. In the Eu(III)- and UO22+-HA systems aggregate morphologies at near neutral pH were similar to those observed in previous studies: optically dense zones (high absorption at the carbon K-edge) are embedded in a matrix of less dense material. C 1s-NEXAFS signatures observed in the different zones, i.e., the intensity of the characteristic complexation feature previously experimentally described and recently theoretically characterized, strongly depends on sample pH. In the alkaline regime (pH 9) with added carbonate, co-precipitation of Eu(III)-carbonate (or ternary carbonate/(oxo)hydroxide complexes) with the Eu(III)-HA majority fraction is observed but Eu(III) binding to HA over carbonate in the dense zones seems to be favoured. The UO22+-HA system exhibits in alkaline solution more compact morphologies combined with a strong metal ion complexation effect in the NEXAFS. Eu(III) and UO22+ polyacrylic acid (PAA) aggregates used as HA model systems show similar spectral trends; these aggregates exhibit highly branched morphologies without segregation into zones with different NEXAFS signatures. The chemical environment such as pH or the type of metal cation strongly influences both HA aggregate morphologies and NEXAFS spectral signatures. These can, in turn, be used as indicators of the strength of lanthanide or actinide ion bound HA interaction.

1D helix, 2D brick-wall and herringbone, and 3D interpenetration d10 metal-organic framework structures assembled from pyridine-2,6-dicarboxylic acid N-oxide.

PubMed

Wen, Li-Li; Dang, Dong-Bin; Duan, Chun-Ying; Li, Yi-Zhi; Tian, Zheng-Fang; Meng, Qing-Jin

2005-10-03

Five novel interesting d(10) metal coordination polymers, [Zn(PDCO)(H2O)2]n (PDCO = pyridine-2,6-dicarboxylic acid N-oxide) (1), [Zn2(PDCO)2(4,4'-bpy)2(H2O)2.3H2O]n (bpy = bipyridine) (2), [Zn(PDCO)(bix)]n (bix = 1,4-bis(imidazol-1-ylmethyl)benzene) (3), [Zn(PDCO)(bbi).0.5H2O]n (bbi = 1,1'-(1,4-butanediyl)bis(imidazole)) (4), and [Cd(PDCO)(bix)(1.5).1.5H2O]n (5), have been synthesized under hydrothermal conditions and structurally characterized. Polymer 1 possesses a one-dimensional (1D) helical chainlike structure with 4(1) helices running along the c-axis with a pitch of 10.090 Angstroms. Polymer 2 has an infinite chiral two-dimensional (2D) brick-wall-like layer structure in the ac plane built from achiral components, while both 3 and 4 exhibit an infinite 2D herringbone architecture, respectively extended in the ac and ab plane. Polymer 5 features a most remarkable and unique three-dimensional (3D) porous framework with 2-fold interpenetration related by symmetry, which contains channels in the b and c directions, both distributed in a rectangular grid fashion. Compounds 1-5, with systematic variation in dimensionality from 1D to 2D to 3D, are the first examples of d(10) metal coordination polymers into which pyridinedicarboxylic acid N-oxide has been introduced. In addition, polymers 1, 4, and 5 display strong blue fluorescent emissions in the solid state. Polymer 3 exhibits a strong SHG response, estimated to be approximately 0.9 times that of urea.

Associations between joint attention and language in autism spectrum disorder and typical development: A systematic review and meta-regression analysis.

PubMed

Bottema-Beutel, Kristen

2016-10-01

Using a structured literature search and meta-regression procedures, this study sought to determine whether associations between joint attention and language are moderated by group (autism spectrum disorder [ASD] vs. typical development [TD]), joint attention type (responding to joint attention [RJA] vs. other), and other study design features and participant characteristics. Studies were located using database searches, hand searches, and electronic requests for data from experts in the field. This resulted in 71 reports or datasets and 605 effect sizes, representing 1,859 participants with ASD and 1,835 TD participants. Meta-regression was used to answer research questions regarding potential moderators of the effect sizes of interest, which were Pearson's r values quantifying the association between joint attention and language variables. In the final models, conducted separately for each language variable, effect sizes were significantly higher for the ASD group as compared to the TD group, and for RJA as compared to non-RJA joint attention types. Approximate mental age trended toward significance for the expressive language model. Joint attention may be more tightly tied to language in children with ASD as compared to TD children because TD children exhibit joint attention at sufficient thresholds so that language development becomes untethered to variations in joint attention. Conversely, children with ASD who exhibit deficits in joint attention develop language contingent upon their joint attention abilities. Because RJA was more strongly related to language than other types of joint attention, future research should involve careful consideration of the operationalization and measurement of joint attention constructs. Autism Res 2016, 9: 1021-1035. © 2016 International Society for Autism Research, Wiley Periodicals, Inc. © 2016 International Society for Autism Research, Wiley Periodicals, Inc.

Dynamic vertical profiles of peat porewater chemistry in a northern peatland

Treesearch

Natalie A. Griffiths; Stephen D. Sebestyen

2016-01-01

We measured pH, cations, nutrients, and total organic carbon (TOC) over 3 years to examine weekly to monthly variability in porewater chemistry depth profiles (0–3.0 m) in an ombrotrophic bog in Minnesota, USA. We also compared temporal variation at one location to spatial variation in depth profiles at 16 locations across the bog. Most solutes exhibited large...

Freezing and desiccation tolerance in entomopathogenic nematodes: diversity and correlation of traits.

PubMed

Shapiro-Ilan, David I; Brown, Ian; Lewis, Edwin E

2014-03-01

The ability of entomopathogenic nematodes to tolerate environmental stress such as desiccating or freezing conditions, can contribute significantly to biocontrol efficacy. Thus, in selecting which nematode to use in a particular biocontrol program, it is important to be able to predict which strain or species to use in target areas where environmental stress is expected. Our objectives were to (i) compare inter- and intraspecific variation in freeze and desiccation tolerance among a broad array of entomopathogenic nematodes, and (ii) determine if freeze and desiccation tolerance are correlated. In laboratory studies we compared nematodes at two levels of relative humidity (RH) (97% and 85%) and exposure periods (24 and 48 h), and nematodes were exposed to freezing temperatures (-2°C) for 6 or 24 h. To assess interspecific variation, we compared ten species including seven that are of current or recent commercial interest: Heterorhabditis bacteriophora (VS), H. floridensis, H. georgiana, (Kesha), H. indica (HOM1), H. megidis (UK211), Steinernema carpocapsae (All), S. feltiae (SN), S. glaseri (VS), S. rarum (17C&E), and S. riobrave (355). To assess intraspecific variation we compared five strains of H. bacteriophora (Baine, Fl1-1, Hb, Oswego, and VS) and four strains of S. carpocapsae (All, Cxrd, DD136, and Sal), and S. riobrave (355, 38b, 7-12, and TP). S. carpocapsae exhibited the highest level of desiccation tolerance among species followed by S. feltiae and S. rarum; the heterorhabditid species exhibited the least desiccation tolerance and S. riobrave and S. glaseri were intermediate. No intraspecific variation was observed in desiccation tolerance; S. carpocapsae strains showed higher tolerance than all H. bacteriophora or S. riobrave strains yet there was no difference detected within species. In interspecies comparisons, poor freeze tolerance was observed in H. indica, and S. glaseri, S. rarum, and S. riobrave whereas H. georgiana and S. feltiae exhibited the highest freeze tolerance, particularly in the 24-h exposure period. Unlike desiccation tolerance, substantial intraspecies variation in freeze tolerance was observed among H. bacteriophora and S. riobrave strains, yet within species variation was not detected among S. carpocapsae strains. Correlation analysis did not detect a relationship between freezing and desiccation tolerance.

SPECTRAL VARIATIONS OF Of?p OBLIQUE MAGNETIC ROTATOR CANDIDATES IN THE MAGELLANIC CLOUDS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Walborn, Nolan R.; Morrell, Nidia I.; Nazé, Yaël

2015-10-15

Optical spectroscopic monitoring has been conducted of two O stars in the SMC and one in the LMC, the spectral characteristics of which place them in the Of?p category, which has been established in the Galaxy to consist of oblique magnetic rotators. All of these Magellanic stars show systematic spectral variations typical of the Of?p class, further strengthening their magnetic candidacy to the point of virtual certainty. The spectral variations are related to photometric variations derived from Optical Gravitational Lensing Experiment data by Nazé et al. in a parallel study, which yields rotational periods for two of them. Now circularmore » spectropolarimetry is required to measure their fields, and ultraviolet spectroscopy to further characterize their low-metallicity, magnetically confined winds, in support of hydrodynamical analyses.« less

Convergent evolution of sexual shape dimorphism in Diptera.

PubMed

Bonduriansky, Russell

2006-05-01

Several patterns of sexual shape dimorphism, such as male body elongation, eye stalks, or extensions of the exoskeleton, have evolved repeatedly in the true flies (Diptera). Although these dimorphisms may have evolved in response to sexual selection on male body shape, conserved genetic factors may have contributed to this convergent evolution, resulting in stronger phenotypic convergence than might be expected from functional requirements alone. I compared phenotypic variation in body shape in two distantly related species exhibiting sexually dimorphic body elongation: Prochyliza xanthostoma (Piophilidae) and Telostylinus angusticollis (Neriidae). Although sexual selection appears to act differently on male body shape in these species, they exhibited strikingly similar patterns of sexual dimorphism. Likewise, patterns of within-sex shape variation were similar in the two species, particularly in males: relative elongation of the male head capsule, antenna, and legs was associated with reduced head capsule width and wing length, but was nearly independent of variation in thorax length. However, the two species presented contrasting patterns of static allometry: male sexual traits exhibited elevated allometric slopes in T. angusticollis, but not in P. xanthostoma. These results suggest that a shared pattern of covariation among traits may have channeled the evolution of sexually dimorphic body elongation in these species. Nonetheless, static allometries may have been shaped by species-specific selection pressures or genetic architectures. Copyright 2006 Wiley-Liss, Inc.

Towards a Systematic Search for Triggered Seismic Events in the USA

NASA Astrophysics Data System (ADS)

Tang, V.; Chao, K.; Van der Lee, S.

2017-12-01

Dynamic triggering of small earthquakes and tectonic tremor by small stress variations associated with passing surface waves from large-magnitude teleseismic earthquakes have been observed in seismically active regions in the western US. Local stress variations as small as 5 10 kPa can suffice to advance slip on local faults. Observations of such triggered events share certain distinct characteristics. With an eye towards an eventual application of machine learning, we began a systematic search for dynamically triggered seismic events in the USA that have these characteristics. Such a systematic survey has the potential to help us to better understand the fundamental process of dynamic triggering and hazards implied by it. Using visual inspection on top of timing and frequency based selection criteria for these seismic phenomena, our search yielded numerous false positives, indicating the challenge posed by moving from ad-hoc observations of dynamic triggering to a systematic search that also includes a catalog of non-triggering, even when sufficient stress variations are supplied. Our search includes a dozen large earthquakes that occurred during the tenure of USArray. One of these earthquakes (11 April 2012 Mw8.6 Sumatra), for example, was observed by USArray-TA stations in the Midwest and other station networks (such as PB and UW), and yielded candidate-triggered events at 413 stations. We kept 79 of these observations after closer visual inspection of the observed events suggested distinct P and S arrivals from a local earthquake, or a tremor modulation with the same period as the surface wave, among other criteria. We confirmed triggered seismic events in 63 stations along the western plate boundary where triggered events have previously been observed. We also newly found triggered tremor sources in eastern Oregon and Yellowstone, and candidate-triggered earthquake sources in New Mexico and Minnesota. Learning whether 14 of remaining candidates are confirmed as triggered events or not will provide constraints on the state of intraplate stress in the USA. Learning what it takes to discriminate between triggered events and false positives will be important for future monitoring practices.

A method for inferring the rate of evolution of homologous characters that can potentially improve phylogenetic inference, resolve deep divergence and correct systematic biases.

PubMed

Cummins, Carla A; McInerney, James O

2011-12-01

Current phylogenetic methods attempt to account for evolutionary rate variation across characters in a matrix. This is generally achieved by the use of sophisticated evolutionary models, combined with dense sampling of large numbers of characters. However, systematic biases and superimposed substitutions make this task very difficult. Model adequacy can sometimes be achieved at the cost of adding large numbers of free parameters, with each parameter being optimized according to some criterion, resulting in increased computation times and large variances in the model estimates. In this study, we develop a simple approach that estimates the relative evolutionary rate of each homologous character. The method that we describe uses the similarity between characters as a proxy for evolutionary rate. In this article, we work on the premise that if the character-state distribution of a homologous character is similar to many other characters, then this character is likely to be relatively slowly evolving. If the character-state distribution of a homologous character is not similar to many or any of the rest of the characters in a data set, then it is likely to be the result of rapid evolution. We show that in some test cases, at least, the premise can hold and the inferences are robust. Importantly, the method does not use a "starting tree" to make the inference and therefore is tree independent. We demonstrate that this approach can work as well as a maximum likelihood (ML) approach, though the ML method needs to have a known phylogeny, or at least a very good estimate of that phylogeny. We then demonstrate some uses for this method of analysis, including the improvement in phylogeny reconstruction for both deep-level and recent relationships and overcoming systematic biases such as base composition bias. Furthermore, we compare this approach to two well-established methods for reweighting or removing characters. These other methods are tree-based and we show that they can be systematically biased. We feel this method can be useful for phylogeny reconstruction, understanding evolutionary rate variation, and for understanding selection variation on different characters.

A Systematic Review of Sensory Processing Interventions for Children with Autism Spectrum Disorders

ERIC Educational Resources Information Center

Case-Smith, Jane; Weaver, Lindy L.; Fristad, Mary A.

2015-01-01

Children with autism spectrum disorders often exhibit co-occurring sensory processing problems and receive interventions that target self-regulation. In current practice, sensory interventions apply different theoretic constructs, focus on different goals, use a variety of sensory modalities, and involve markedly disparate procedures. Previous…

Teacher-Researcher Partnerships to Improve Social Behavior through Social Stories

ERIC Educational Resources Information Center

Agosta, E.; Graetz, J. E.; Mastropieri, M. A.; Scruggs, T. E.

2004-01-01

In this project, a partnership between school and university personnel addressed, in a systematic, research-oriented fashion, a classroom problem. A young child with autism exhibited excessively loud screaming, yelling, humming, and other distracting noises during class activities in a special education setting. These disruptive behaviors were a…

Constructing Spatial Meaning: Spatial Affordances in Museum Design

ERIC Educational Resources Information Center

Wineman, Jean D.; Peponis, John

2010-01-01

Informal education in museums is structured through movement in space. This article summarizes a range of research that examines the role of spatial layout in shaping the ways in which visitors explore, engage, and understand museums and museum exhibitions. It is demonstrated that behavior patterns are systematically linked to spatial…

High-Temperature Quantum-Classical Transition in Solid Methane

NASA Astrophysics Data System (ADS)

Zakharov, A. Yu.; Leont'eva, A. V.; Prokhorov, A. Yu.; Erenburg, A. I.

2017-04-01

Some experimental studies have reported that physical properties of solid methane exhibit a number of anomalies in the temperature interval between 0.5 T _tr and T _tr (T _tr is triple point of methane). This paper contains an attempt of systematization and theoretical interpretation of the observed anomalies.

Developing, Implementing, and Assessing an Early Alert System

ERIC Educational Resources Information Center

Tampke, Dale R.

2013-01-01

Early alert systems offer institutions systematic approaches to identifying and intervening with students exhibiting at-risk behaviors. Many of these systems rely on a common format for student referral to central receiving point. Systems at larger institutions often use web-based technology to allow for a scalable (available campus wide) approach…

On the Decision-Making Process in Music Education.

ERIC Educational Resources Information Center

Jorgensen, Estelle R.

1985-01-01

Sketches a conceptual framework for the systematic description of decision-making processes in music education. Refers to existing formulations in education, management, marketing, and economics. Lists decision-making phases in music education, each exhibiting the characteristics of a social system. Offers a historical example of each phase. (AYC)

Visually driven chaining of elementary swim patterns into a goal-directed motor sequence: a virtual reality study of zebrafish prey capture.

PubMed

Trivedi, Chintan A; Bollmann, Johann H

2013-01-01

Prey capture behavior critically depends on rapid processing of sensory input in order to track, approach, and catch the target. When using vision, the nervous system faces the problem of extracting relevant information from a continuous stream of input in order to detect and categorize visible objects as potential prey and to select appropriate motor patterns for approach. For prey capture, many vertebrates exhibit intermittent locomotion, in which discrete motor patterns are chained into a sequence, interrupted by short periods of rest. Here, using high-speed recordings of full-length prey capture sequences performed by freely swimming zebrafish larvae in the presence of a single paramecium, we provide a detailed kinematic analysis of first and subsequent swim bouts during prey capture. Using Fourier analysis, we show that individual swim bouts represent an elementary motor pattern. Changes in orientation are directed toward the target on a graded scale and are implemented by an asymmetric tail bend component superimposed on this basic motor pattern. To further investigate the role of visual feedback on the efficiency and speed of this complex behavior, we developed a closed-loop virtual reality setup in which minimally restrained larvae recapitulated interconnected swim patterns closely resembling those observed during prey capture in freely moving fish. Systematic variation of stimulus properties showed that prey capture is initiated within a narrow range of stimulus size and velocity. Furthermore, variations in the delay and location of swim triggered visual feedback showed that the reaction time of secondary and later swims is shorter for stimuli that appear within a narrow spatio-temporal window following a swim. This suggests that the larva may generate an expectation of stimulus position, which enables accelerated motor sequencing if the expectation is met by appropriate visual feedback.

Clustering evolving proteins into homologous families.

PubMed

Chan, Cheong Xin; Mahbob, Maisarah; Ragan, Mark A

2013-04-08

Clustering sequences into groups of putative homologs (families) is a critical first step in many areas of comparative biology and bioinformatics. The performance of clustering approaches in delineating biologically meaningful families depends strongly on characteristics of the data, including content bias and degree of divergence. New, highly scalable methods have recently been introduced to cluster the very large datasets being generated by next-generation sequencing technologies. However, there has been little systematic investigation of how characteristics of the data impact the performance of these approaches. Using clusters from a manually curated dataset as reference, we examined the performance of a widely used graph-based Markov clustering algorithm (MCL) and a greedy heuristic approach (UCLUST) in delineating protein families coded by three sets of bacterial genomes of different G+C content. Both MCL and UCLUST generated clusters that are comparable to the reference sets at specific parameter settings, although UCLUST tends to under-cluster compositionally biased sequences (G+C content 33% and 66%). Using simulated data, we sought to assess the individual effects of sequence divergence, rate heterogeneity, and underlying G+C content. Performance decreased with increasing sequence divergence, decreasing among-site rate variation, and increasing G+C bias. Two MCL-based methods recovered the simulated families more accurately than did UCLUST. MCL using local alignment distances is more robust across the investigated range of sequence features than are greedy heuristics using distances based on global alignment. Our results demonstrate that sequence divergence, rate heterogeneity and content bias can individually and in combination affect the accuracy with which MCL and UCLUST can recover homologous protein families. For application to data that are more divergent, and exhibit higher among-site rate variation and/or content bias, MCL may often be the better choice, especially if computational resources are not limiting.

Inferences of Complex Anisotropic Layering and Mantle Flow Beneath the Malawi Rift Zone from Shear-Wave Splitting

NASA Astrophysics Data System (ADS)

Gao, S. S.; Reed, C. A.; Yu, Y.; Liu, K. H.; Chindandali, P. R. N.; Mdala, H. S.; Massinque, B.; Mutamina, D. M.

2016-12-01

Measuring the magnitude and orientation of seismic anisotropy beneath actively extending rift zones provides invaluable estimates of the influence of numerous geodynamic parameters upon their evolution. In order to infer the character and origin of extensional forces acting upon the Malawi Rift Zone (MRZ) and Luangwa Rift Zone (LRZ) of southern Africa, we installed 33 Seismic Arrays For African Rift Initiation (SAFARI) three-component broadband seismic stations in Malawi, Mozambique, and Zambia between 2012-2014. Shear-wave splitting parameters, including the fast-component polarization orientation and the splitting time, are extracted from 142 events recorded during that time period for a total of 642 well-defined PKS, SKKS, and SKS phase measurements. Polarizations trend NE-SW along the western flank of the LRZ, whereupon they demonstrate an abrupt shift to N-S within the rift valley and the eastern flank. SWS orientations shift increasingly counterclockwise toward the east until, at 33°E, they shift from WNW-ESE to ENE-WSW, suggesting a systematic change in dominant mantle fabric orientation. The resulting fast orientations demonstrate remarkable variability within the MRZ, with E-W measurements in the north rotating counterclockwise toward the south to N-S within the southernmost MRZ. Measurements revert to E-W and NE-SW orientations toward the east in Mozambique, suggesting the presence of complex two-layer anisotropy. Azimuthal variations of SWS parameters recorded by stations within the central MRZ exhibit excellent 90° periodicity, further suggesting complex anisotropic layering. Lateral variation of measurements between the northern and southern MRZ imply the modulation of the mantle flow system beneath the active rift zone.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kegel, T.M.

Calibration laboratories are faced with the need to become accredited or registered to one or more quality standards. One requirement common to all of these standards is the need to have in place a measurement assurance program. What is a measurement assurance program? Brian Belanger, in Measurement Assurance Programs: Part 1, describes it as a {open_quotes}quality assurance program for a measurement process that quantifies the total uncertainty of the measurements (both random and systematic components of error) with respect to national or designated standards and demonstrates that the total uncertainty is sufficiently small to meet the user`s requirements.{close_quotes} Rolf Schumachermore » is more specific in Measurement Assurance in Your Own Laboratory. He states, {open_quotes}Measurement assurance is the application of broad quality control principles to measurements of calibrations.{close_quotes} Here, the focus is on one important part of any measurement assurance program: implementation of statistical process control (SPC). Paraphrasing Juran`s Quality Control Handbook, a process is in statistical control if the only observed variations are those that can be attributed to random causes. Conversely, a process that exhibits variations due to assignable causes is not in a state of statistical control. Finally, Carrol Croarkin states, {open_quotes}In the measurement assurance context the measurement algorithm including instrumentation, reference standards and operator interactions is the process that is to be controlled, and its direct product is the measurement per se. The measurements are assumed to be valid if the measurement algorithm is operating in a state of control.{close_quotes} Implicit in this statement is the important fact that an out-of-control process cannot produce valid measurements. 7 figs.« less

Internal Variations in Empirical Oxygen Abundances for Giant H II Regions in the Galaxy NGC 2403

NASA Astrophysics Data System (ADS)

Mao, Ye-Wei; Lin, Lin; Kong, Xu

2018-02-01

This paper presents a spectroscopic investigation of 11 {{H}} {{II}} regions in the nearby galaxy NGC 2403. The {{H}} {{II}} regions are observed with a long-slit spectrograph mounted on the 2.16 m telescope at XingLong station of National Astronomical Observatories of China. For each of the {{H}} {{II}} regions, spectra are extracted at different nebular radii along the slit-coverage. Oxygen abundances are empirically estimated from the strong-line indices R23, N2O2, O3N2, and N2 for each spectrophotometric unit, with both observation- and model-based calibrations adopted into the derivation. Radial profiles of these diversely estimated abundances are drawn for each nebula. In the results, the oxygen abundances separately estimated with the prescriptions on the basis of observations and models, albeit from the same spectral index, systematically deviate from each other; at the same time, the spectral indices R23 and N2O2 are distributed with flat profiles, whereas N2 and O3N2 exhibit apparent gradients with the nebular radius. Because our study naturally samples various ionization levels, which inherently decline at larger radii within individual {{H}} {{II}} regions, the radial distributions indicate not only the robustness of R23 and N2O2 against ionization variations but also the sensitivity of N2 and O3N2 to the ionization parameter. The results in this paper provide observational corroboration of the theoretical prediction about the deviation in the empirical abundance diagnostics. Our future work is planned to investigate metal-poor {{H}} {{II}} regions with measurable T e, in an attempt to recalibrate the strong-line indices and consequently disclose the cause of the discrepancies between the empirical oxygen abundances.

The behavior of U- and Th-series nuclides in groundwater

USGS Publications Warehouse

Porcelli, D.; Swarzenski, P.W.

2003-01-01

Groundwater has long been an active area of research driven by its importance both as a societal resource and as a component in the global hydrological cycle. Key issues in groundwater research include inferring rates of transport of chemical constituents, determining the ages of groundwater, and tracing water masses using chemical fingerprints. While information on the trace elements pertinent to these topics can be obtained from aquifer tests using experimentally introduced tracers, and from laboratory experiments on aquifer materials, these studies are necessarily limited in time and space. Regional studies of aquifers can focus on greater scales and time periods, but must contend with greater complexities and variations. In this regard, the isotopic systematics of the naturally occurring radionuclides in the U- and Th- decay series have been invaluable in investigating aquifer behavior of U, Th, and Ra. These nuclides are present in all groundwaters and are each represented by several isotopes with very different half-lives, so that processes occurring over a range of time-scales can be studied (Table 1⇓). Within the host aquifer minerals, the radionuclides in each decay series are generally expected to be in secular equilibrium and so have equal activities (see Bourdon et al. 2003). In contrast, these nuclides exhibit strong relative fractionations within the surrounding groundwaters that reflect contrasting behavior during release into the water and during interaction with the surrounding host aquifer rocks. Radionuclide data can be used, within the framework of models of the processes involved, to obtain quantitative assessments of radionuclide release from aquifer rocks and groundwater migration rates. The isotopic variations that are generated also have the potential for providing fingerprints for groundwaters from specific aquifer environments, and have even been explored as a means for calculating groundwater ages.

Improving qPCR telomere length assays: Controlling for well position effects increases statistical power.

PubMed

Eisenberg, Dan T A; Kuzawa, Christopher W; Hayes, M Geoffrey

2015-01-01

Telomere length (TL) is commonly measured using quantitative PCR (qPCR). Although, easier than the southern blot of terminal restriction fragments (TRF) TL measurement method, one drawback of qPCR is that it introduces greater measurement error and thus reduces the statistical power of analyses. To address a potential source of measurement error, we consider the effect of well position on qPCR TL measurements. qPCR TL data from 3,638 people run on a Bio-Rad iCycler iQ are reanalyzed here. To evaluate measurement validity, correspondence with TRF, age, and between mother and offspring are examined. First, we present evidence for systematic variation in qPCR TL measurements in relation to thermocycler well position. Controlling for these well-position effects consistently improves measurement validity and yields estimated improvements in statistical power equivalent to increasing sample sizes by 16%. We additionally evaluated the linearity of the relationships between telomere and single copy gene control amplicons and between qPCR and TRF measures. We find that, unlike some previous reports, our data exhibit linear relationships. We introduce the standard error in percent, a superior method for quantifying measurement error as compared to the commonly used coefficient of variation. Using this measure, we find that excluding samples with high measurement error does not improve measurement validity in our study. Future studies using block-based thermocyclers should consider well position effects. Since additional information can be gleaned from well position corrections, rerunning analyses of previous results with well position correction could serve as an independent test of the validity of these results. © 2015 Wiley Periodicals, Inc.

Household coal use and lung cancer: systematic review and meta-analysis of case–control studies, with an emphasis on geographic variation

PubMed Central

Hosgood, H Dean; Wei, Hu; Sapkota, Amir; Choudhury, Imran; Bruce, Nigel; Smith, Kirk R; Rothman, Nathaniel; Lan, Qing

2011-01-01

Background Emissions from household coal combustion associated with cooking and heating are an important public health issue, particularly in China where hundreds of millions of people are exposed. Although coal emissions are a known human carcinogen, there is still uncertainty about the level of risk for lung and other cancers. Methods We performed a meta-analysis on 25 case–control studies (10 142 cases and 13 416 controls) to summarize the association between household coal use and lung cancer risk, and to explore the effect modification of this association by geographical location. Results Using random-effects models, household coal use was found to be associated with lung cancer risk among all studies throughout the world [odds ratio (OR) = 2.15; 95% confidence interval (CI) = 1.61–2.89, Nstudies = 25], and particularly among those studies carried out in mainland China and Taiwan (OR = 2.27; 95% CI = 1.65–3.12, Nstudies = 20). Stratification by regions of mainland China and Taiwan found a variation in effects across the regions, with south/southeastern (OR = 3.27; 95% CI = 1.27–8.42, Nstudies = 3) and southwestern China (OR = 2.98; 95% CI = 1.18–7.53, Nstudies = 3) experiencing the highest risk. The elevated risk associated with coal use throughout Asia was also observed when stratifying studies by gender, smoking status, sample size, design (population vs hospital case–control) and publication language. No significant publication bias was found (pBegg’s = 0.15). Conclusions Our results provide evidence that although the carcinogenic effect of coal use varies by location, coals from many locations exhibit elevated lung cancer risks. PMID:21278196

Catechol-O-Methyltransferase and UDP-Glucuronosyltransferases in the Metabolism of Baicalein in Different Species.

PubMed

Zhang, Ruiya; Cui, Yonglei; Wang, Yan; Tian, Xiangge; Zheng, Lu; Cong, HaiJian; Wu, Bin; Huo, Xiaokui; Wang, Chao; Zhang, BaoJing; Wang, Xiaobo; Yu, Zhonghui

2017-12-01

Baicalein is the major bioactive flavonoid in some herb medicines and dietary plants; however, the detailed metabolism pathway of its major metabolite oroxylin A-7-O-β-D-glucuronide in human was not clear. It was important to illustrate the major metabolic enzymes that participate in its elimination for the clinic use of baicalein. We first revealed a two-step metabolism profile for baicalein and illustrated the combination of catechol-O-methyltransferase (COMT) and uridine diphosphate-glucuronosyltransferases (UGTs) in drug metabolism, further evaluated its bioactivity variation during drug metabolism. The metabolism profiles were systematically characterized in different human biology preparations; after then, the anti-inflammatory activities of metabolites were evaluated in LPS-induced RAW264.7 cell. The first-step metabolite of baicalein was isolated and identified as oroxylin A; soluble-bound COMT (S-COMT) was the major enzyme responsible for its biotransformation. Specially, position 108 mutation of S-COMT significantly decreases the elimination. Meantime, oroxylin A was rapidly metabolized by UGTs, UGT1A1, -1A3, -1A6, -1A7, -1A8, -1A9, and -1A10 which were involved in the glucuronidation. Considerable species differences were observed with 1060-fold K m (3.05 ± 1.86-3234 ± 475 μM) and 330-fold CL int (5.93-1973 μL/min/mg) variations for baicalein metabolism. Finally, the middle metabolite oroxylin A exhibited a potent anti-inflammatory activity with the IC 50 value of 28 μM. The detailed kinetic parameters indicated that COMT provide convenience for the next glucuronidation; monkey would be a preferred animal model for the preclinical investigation of baicalein. Importantly, oroxylin A should be reconsidered in evaluating baicalein efficacy against inflammatory diseases.

Assessing intraspecific variation in effective dispersal along an altitudinal gradient: a test in two Mediterranean high-mountain plants.

PubMed

Lara-Romero, Carlos; Robledo-Arnuncio, Juan J; García-Fernández, Alfredo; Iriondo, Jose M

2014-01-01

Plant recruitment depends among other factors on environmental conditions and their variation at different spatial scales. Characterizing dispersal in contrasting environments may thus be necessary to understand natural intraspecific variation in the processes underlying recruitment. Silene ciliata and Armeria caespitosa are two representative species of cryophilic pastures above the tree line in Mediterranean high mountains. No explicit estimations of dispersal kernels have been made so far for these or other high-mountain plants. Such data could help to predict their dispersal and recruitment patterns in a context of changing environments under ongoing global warming. We used an inverse modelling approach to analyse effective seed dispersal patterns in five populations of both Silene ciliata and Armeria caespitosa along an altitudinal gradient in Sierra de Guadarrama (Madrid, Spain). We considered four commonly employed two-dimensional seedling dispersal kernels exponential-power, 2Dt, WALD and log-normal. No single kernel function provided the best fit across all populations, although estimated mean dispersal distances were short (<1 m) in all cases. S. ciliata did not exhibit significant among-population variation in mean dispersal distance, whereas significant differences in mean dispersal distance were found in A. caespitosa. Both S. ciliata and A. caespitosa exhibited among-population variation in the fecundity parameter and lacked significant variation in kernel shape. This study illustrates the complexity of intraspecific variation in the processes underlying recruitment, showing that effective dispersal kernels can remain relatively invariant across populations within particular species, even if there are strong variations in demographic structure and/or physical environment among populations, while the invariant dispersal assumption may not hold for other species in the same environment. Our results call for a case-by-case analysis in a wider range of plant taxa and environments to assess the prevalence and magnitude of intraspecific dispersal variation.

The interaction between nitrogen and phosphorous is a strong predictor of intra-plant variation in nitrogen isotope composition in a desert species

DOE PAGES

Zhang, Jinxin; Gu, Lianhong; Zhang, Jingbo; ...

2017-01-11

Understanding intra-plant variations in δ 15N is essential for fully utilizing the potential of δ 15N as an integrator of the terrestrial nitrogen (N) cycle and as an indicator of the relative limitation of N and phosphorous (P) on plant growth. Studying such variations can also yield insights into N metabolism by plant as a whole or by specific organs. However, few researchers have systematically evaluated intra-plant variations in δ 15N and their relationships with organ nutrient contents. We excavated whole plant architectures of Nitraria tangutorum Bobrov, a C 3 species of vital regional ecological importance, in two deserts inmore » northwestern China. We systematically and simultaneously measured N isotope ratios and N and P contents of different parts of the excavated plants. We found that intra-plant variations in δ 15N of N. tangutorum were positively correlated with corresponding organ N and P contents. However, it was the N × P interaction, not N and P individually or their linear combination, that was the strongest predictor of intra-plant δ 15N. Additionally, we showed that root δ 15N increased with depth into soil, a pattern similar to profiles of soil δ 15N reported by previous studies in different ecosystems. We hypothesized that the strong positive intra-plant δ 15N–N and P relationships are caused by three processes acting in conjunction: (1) N and P content-driven fractionating exchanges of ammonia between leaves and the atmosphere (volatilization) during photorespiration, (2) resorption and remobilization of N and P from senescing leaves, and (3) mixture of the re-translocated foliar N and P with existing pools in stems and roots. To test our hypothesis, future studies should investigate plant N volatilization and associated isotope fractionation and intra-plant variations in δ 15N in different species across ecosystems and climates.« less

The interaction between nitrogen and phosphorous is a strong predictor of intra-plant variation in nitrogen isotope composition in a desert species

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhang, Jinxin; Gu, Lianhong; Zhang, Jingbo

Understanding intra-plant variations in δ 15N is essential for fully utilizing the potential of δ 15N as an integrator of the terrestrial nitrogen (N) cycle and as an indicator of the relative limitation of N and phosphorous (P) on plant growth. Studying such variations can also yield insights into N metabolism by plant as a whole or by specific organs. However, few researchers have systematically evaluated intra-plant variations in δ 15N and their relationships with organ nutrient contents. We excavated whole plant architectures of Nitraria tangutorum Bobrov, a C 3 species of vital regional ecological importance, in two deserts inmore » northwestern China. We systematically and simultaneously measured N isotope ratios and N and P contents of different parts of the excavated plants. We found that intra-plant variations in δ 15N of N. tangutorum were positively correlated with corresponding organ N and P contents. However, it was the N × P interaction, not N and P individually or their linear combination, that was the strongest predictor of intra-plant δ 15N. Additionally, we showed that root δ 15N increased with depth into soil, a pattern similar to profiles of soil δ 15N reported by previous studies in different ecosystems. We hypothesized that the strong positive intra-plant δ 15N–N and P relationships are caused by three processes acting in conjunction: (1) N and P content-driven fractionating exchanges of ammonia between leaves and the atmosphere (volatilization) during photorespiration, (2) resorption and remobilization of N and P from senescing leaves, and (3) mixture of the re-translocated foliar N and P with existing pools in stems and roots. To test our hypothesis, future studies should investigate plant N volatilization and associated isotope fractionation and intra-plant variations in δ 15N in different species across ecosystems and climates.« less

Addressing unwarranted clinical variation: A rapid review of current evidence.

PubMed

Harrison, Reema; Manias, Elizabeth; Mears, Stephen; Heslop, David; Hinchcliff, Reece; Hay, Liz

2018-05-15

Unwarranted clinical variation (UCV) can be described as variation that can only be explained by differences in health system performance. There is a lack of clarity regarding how to define and identify UCV and, once identified, to determine whether it is sufficiently problematic to warrant action. As such, the implementation of systemic approaches to reducing UCV is challenging. A review of approaches to understand, identify, and address UCV was undertaken to determine how conceptual and theoretical frameworks currently attempt to define UCV, the approaches used to identify UCV, and the evidence of their effectiveness. Rapid evidence assessment (REA) methodology was used. A range of text words, synonyms, and subject headings were developed for the major concepts of unwarranted clinical variation, standards (and deviation from these standards), and health care environment. Two electronic databases (Medline and Pubmed) were searched from January 2006 to April 2017, in addition to hand searching of relevant journals, reference lists, and grey literature. Results were merged using reference-management software (Endnote) and duplicates removed. Inclusion criteria were independently applied to potentially relevant articles by 3 reviewers. Findings were presented in a narrative synthesis to highlight key concepts addressed in the published literature. A total of 48 relevant publications were included in the review; 21 articles were identified as eligible from the database search, 4 from hand searching published work and 23 from the grey literature. The search process highlighted the voluminous literature reporting clinical variation internationally; yet, there is a dearth of evidence regarding systematic approaches to identifying or addressing UCV. Wennberg's classification framework is commonly cited in relation to classifying variation, but no single approach is agreed upon to systematically explore and address UCV. The instances of UCV that warrant investigation and action are largely determined at a systems level currently, and stakeholder engagement in this process is limited. Lack of consensus on an evidence-based definition for UCV remains a substantial barrier to progress in this field. © 2018 John Wiley & Sons, Ltd.

Genetic and Cytological Analyses of the Natural Variation of Seed Number per Pod in Rapeseed (Brassica napus L.)

PubMed Central

Yang, Yuhua; Wang, Ying; Zhan, Jiepeng; Shi, Jiaqin; Wang, Xinfa; Liu, Guihua; Wang, Hanzhong

2017-01-01

Seed number is one of the key traits related to plant evolution/domestication and crop improvement/breeding. In rapeseed germplasm, the seed number per pod (SNPP) shows a very wide variation from several to nearly 30; however, the underlying causations/mechanisms for this variation are poorly known. In the current study, the genetic and cytological bases for the natural variation of SNPP in rapeseed was firstly and systematically investigated using the representative four high-SNPP and five low-SNPP lines. The results of self- or cross-pollination experiment between the high- and low-SNPP lines showed that the natural variation of SNPP was mainly controlled by maternal effect (mean = 0.79), followed by paternal effect (mean = 0.21). Analysis of the data using diploid seed embryo–cytoplasmic–maternal model further showed that the maternal genotype, embryo, and cytoplasm effects, respectively, explained 47.6, 35.2, and 7.5% of the genetic variance. In addition, the analysis of combining ability showed that for the SNPP of hybrid F1 was mainly determined by the general combining ability of parents (63.0%), followed by special combining ability of parental combination (37.0%). More importantly, the cytological observation showed that the SNPP difference between the high- and low-SNPP lines was attributable to the accumulative differences in its components. Of which, the number of ovules, the proportion of fertile ovules, the proportion of fertile ovules to be fertilized, and the proportion of fertilized ovules to develop into seeds accounted for 30.7, 18.2, 7.1, and 43.9%, respectively. The accordant results of both genetic and cytological analyses provide solid evidences and systematic insights to further understand the mechanisms underlying the natural variation of SNPP, which will facilitate the development of high-yield cultivars in rapeseed. PMID:29163611

Differences in the spectra of cosmic ray nuclear species below approximately 5 GeV/nuc

NASA Technical Reports Server (NTRS)

Webber, W. R.; Lezniak, J. A.; Kish, J.

1974-01-01

Extension of previous measurements made at high energies, which show clear evidence for energy-dependent changes in cosmic ray composition, to lower energies. The new data point to the fact that these spectral differences extend over the entire energy band from a few hundred MeV/nucleon to several tens of GeV/nucleon. The details of these composition variations are examined by studying in a systematic way the variations of the ratios of secondary to primary and different groups of primary cosmic ray nuclei.

Effects of sampling strategy, detection probability, and independence of counts on the use of point counts

USGS Publications Warehouse

Pendleton, G.W.; Ralph, C. John; Sauer, John R.; Droege, Sam

1995-01-01

Many factors affect the use of point counts for monitoring bird populations, including sampling strategies, variation in detection rates, and independence of sample points. The most commonly used sampling plans are stratified sampling, cluster sampling, and systematic sampling. Each of these might be most useful for different objectives or field situations. Variation in detection probabilities and lack of independence among sample points can bias estimates and measures of precision. All of these factors should be con-sidered when using point count methods.

Spatial and temporal variations in infrared emissions of the upper atmosphere. 1. Atomic oxygen (λ 63 μm) emission

NASA Astrophysics Data System (ADS)

Semenov, A. I.; Medvedeva, I. V.; Perminov, V. I.; Khomich, V. Yu.

2016-09-01

Rocket and balloon measurement data on atomic-oxygen (λ 63 µm) emission in the upper atmosphere are presented. The data from the longest (1989-2003) period of measurements of the atomic-oxygen (λ 63 µm) emission intensity obtained by spectral instruments on sounding balloons at an altitude of 38 km at midlatitudes have been systematized and analyzed. Regularities in diurnal and seasonal variations in the intensity of this emission, as well as in its relation with solar activity, have been revealed.

Boundary-layer cumulus over land: Some observations and conceptual models

DOE Office of Scientific and Technical Information (OSTI.GOV)

Stull, R.B.

1993-09-01

Starting in 1980, the Boundary Layer Research Team at the University of Wisconsin has been systematically studying the formation and evolution of nonprecipitating boundary-layer cumulus clouds (BLCu) in regions of fair weather (anticyclones) over land (Stull, 1980). Our approach is to quantify the average statistical characteristics of the surface, thermals, boundary layer, and clouds over horizontal regions of roughly 20 km in diameter. Within such a region over land, there is typically quite a variation in land use, and associated variations in surface albedo and moisture.

[Development of intelligence in old age].

PubMed

Rott, C

1990-01-01

This article attempts to find the structure of a selected spectrum of intelligence. A combination of longitudinal and cross-sectional methods is applied. Two dimensions were found, which can be named as "crystallized" and "fluid" abilities (in the sense of Horn & Cattell). Whereas, the crystallized abilities do not show any systematic variation from age 61 to 83, fluid abilities decline with age. Schaie's three-component-model is not able to describe differences and variations of crystallized intelligence. Within fluid intelligence, age changes are more important than cohort differences. There are hints that structural changes take place.

IR temperatures of Mauna Loa caldera obtained with multispectral thermal imager

NASA Astrophysics Data System (ADS)

Pendergast, Malcolm M.; O'Steen, Byron L.; Kurzeja, Robert J.

2002-01-01

A survey of surface temperatures of the Mauna Loa caldera during 7/14/00 and 7/15/00 was made by SRTC in conjunction with a MTI satellite image collection. The general variation of surface temperature appears quite predictable responding to solar heating. The analysis of detailed times series of temperature indicates systematic variations in temperature of 5 C corresponding to time scales of 3-5 minutes and space scales of 10-20 m. The average temperature patterns are consistent with those predicted by the Regional Atmospheric Modeling System (RAMS).

Effects of Variation and Prior Knowledge on Abstract Concept Learning

ERIC Educational Resources Information Center

Braithwaite, David W.; Goldstone, Robert L.

2015-01-01

Learning abstract concepts through concrete examples may promote learning at the cost of inhibiting transfer. The present study investigated one approach to solving this problem: systematically varying superficial features of the examples. Participants learned to solve problems involving a mathematical concept by studying either superficially…

William Burke Critchfield

Treesearch

Connie Millar

1990-01-01

William B. Critchfield died July 11, 1989. He left a legacy unparalleled in forest genetics. Bill made major contributions to understanding genetic variation, hybridization, growth and development, biogeography, paleobotany, systematics, and taxonomy of forest trees, especially pines. In each of these fields, Bill's pioneering work earned him the position of world...

School Choice International

ERIC Educational Resources Information Center

West, Martin R.; Woessmann, Ludger

2009-01-01

Scholars have attempted to discern the effects of competition between the public and private education sectors within the United States and in other countries, but no study has attempted to measure systematically the causal impact of competition by looking at variation across countries. Countries where more people choose to invest in private…