38 CFR 1.653 - Delegation of authority.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 38 Pensions, Bonuses, and Veterans' Relief 1 2011-07-01 2011-07-01 false Delegation of authority. 1.653 Section 1.653 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS GENERAL PROVISIONS Inventions by Employees of Department of Veterans Affairs § 1.653 Delegation of authority. The...

38 CFR 1.653 - Delegation of authority.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 38 Pensions, Bonuses, and Veterans' Relief 1 2010-07-01 2010-07-01 false Delegation of authority. 1.653 Section 1.653 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS GENERAL PROVISIONS Inventions by Employees of Department of Veterans Affairs § 1.653 Delegation of authority. The...

20 CFR 653.109 - Data collection.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 20 Employees' Benefits 3 2014-04-01 2014-04-01 false Data collection. 653.109 Section 653.109... SERVICE SYSTEM Services for Migrant and Seasonal Farmworkers (MSFWs) § 653.109 Data collection. State agencies shall: (a) Collect data on MSFWs, including data on the number (1) contacted through outreach...

20 CFR 653.109 - Data collection.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 20 Employees' Benefits 3 2013-04-01 2013-04-01 false Data collection. 653.109 Section 653.109... SERVICE SYSTEM Services for Migrant and Seasonal Farmworkers (MSFWs) § 653.109 Data collection. State agencies shall: (a) Collect data on MSFWs, including data on the number (1) contacted through outreach...

20 CFR 653.109 - Data collection.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 20 Employees' Benefits 3 2012-04-01 2012-04-01 false Data collection. 653.109 Section 653.109... SERVICE SYSTEM Services for Migrant and Seasonal Farmworkers (MSFWs) § 653.109 Data collection. State agencies shall: (a) Collect data on MSFWs, including data on the number (1) contacted through outreach...

20 CFR 653.109 - Data collection.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 20 Employees' Benefits 3 2011-04-01 2011-04-01 false Data collection. 653.109 Section 653.109... SERVICE SYSTEM Services for Migrant and Seasonal Farmworkers (MSFWs) § 653.109 Data collection. State agencies shall: (a) Collect data on MSFWs, including data on the number (1) contacted through outreach...

20 CFR 653.109 - Data collection.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Data collection. 653.109 Section 653.109... SERVICE SYSTEM Services for Migrant and Seasonal Farmworkers (MSFWs) § 653.109 Data collection. State agencies shall: (a) Collect data on MSFWs, including data on the number (1) contacted through outreach...

Synthetic lipophilic antioxidant BO-653 suppresses HCV replication.

PubMed

Yasui, Fumihiko; Sudoh, Masayuki; Arai, Masaaki; Kohara, Michinori

2013-02-01

The influence of the intracellular redox state on the hepatitis C virus (HCV) life cycle is poorly understood. This study demonstrated the anti-HCV activity of 2,3-dihydro-5-hydroxy-2,2-dipentyl-4,6-di-tert-butylbenzofuran (BO-653), a synthetic lipophilic antioxidant, and examined whether BO-653's antioxidant activity is integral to its anti-HCV activity. The anti-HCV activity of BO-653 was investigated in HuH-7 cells bearing an HCV subgenomic replicon (FLR3-1 cells) and in HuH-7 cells infected persistently with HCV (RMT-tri cells). BO-653 inhibition of HCV replication was also compared with that of several hydrophilic and lipophilic antioxidants. BO-653 suppressed HCV replication in FLR3-1 and RMT-tri cells in a concentration-dependent manner. The lipophilic antioxidants had stronger anti-HCV activities than the hydrophilic antioxidants, and BO-653 displayed the strongest anti-HCV activity of all the antioxidants examined. Therefore, the anti-HCV activity of BO-653 was examined in chimeric mice harboring human hepatocytes infected with HCV. The combination treatment of BO-653 and polyethylene glycol-conjugated interferon-α (PEG-IFN) decreased serum HCV RNA titer more than that seen with PEG-IFN alone. These findings suggest that both the lipophilic property and the antioxidant activity of BO-653 play an important role in the inhibition of HCV replication. Copyright © 2012 Wiley Periodicals, Inc.

44 CFR 65.3 - Requirement to submit new technical data.

Code of Federal Regulations, 2010 CFR

2010-10-01

... technical data. 65.3 Section 65.3 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY... IDENTIFICATION AND MAPPING OF SPECIAL HAZARD AREAS § 65.3 Requirement to submit new technical data. A community's base flood elevations may increase or decrease resulting from physical changes affecting flooding...

7 CFR 653.3 - Adaptation of technical standards.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 7 Agriculture 6 2012-01-01 2012-01-01 false Adaptation of technical standards. 653.3 Section 653.3..., DEPARTMENT OF AGRICULTURE SUPPORT ACTIVITIES TECHNICAL STANDARDS § 653.3 Adaptation of technical standards. Technical standards and criteria developed on a national basis may require special adaptation to meet local...

7 CFR 653.3 - Adaptation of technical standards.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 7 Agriculture 6 2014-01-01 2014-01-01 false Adaptation of technical standards. 653.3 Section 653.3..., DEPARTMENT OF AGRICULTURE SUPPORT ACTIVITIES TECHNICAL STANDARDS § 653.3 Adaptation of technical standards. Technical standards and criteria developed on a national basis may require special adaptation to meet local...

7 CFR 653.3 - Adaptation of technical standards.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 7 Agriculture 6 2011-01-01 2011-01-01 false Adaptation of technical standards. 653.3 Section 653.3..., DEPARTMENT OF AGRICULTURE SUPPORT ACTIVITIES TECHNICAL STANDARDS § 653.3 Adaptation of technical standards. Technical standards and criteria developed on a national basis may require special adaptation to meet local...

7 CFR 653.3 - Adaptation of technical standards.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 7 Agriculture 6 2013-01-01 2013-01-01 false Adaptation of technical standards. 653.3 Section 653.3..., DEPARTMENT OF AGRICULTURE SUPPORT ACTIVITIES TECHNICAL STANDARDS § 653.3 Adaptation of technical standards. Technical standards and criteria developed on a national basis may require special adaptation to meet local...

20 CFR 653.102 - Job information.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 20 Employees' Benefits 3 2013-04-01 2013-04-01 false Job information. 653.102 Section 653.102... SERVICE SYSTEM Services for Migrant and Seasonal Farmworkers (MSFWs) § 653.102 Job information. All State agencies shall make job order information conspicuous and available to MSFWs in all local offices. This...

20 CFR 653.103 - MSFW job applications.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 20 Employees' Benefits 3 2014-04-01 2014-04-01 false MSFW job applications. 653.103 Section 653... EMPLOYMENT SERVICE SYSTEM Services for Migrant and Seasonal Farmworkers (MSFWs) § 653.103 MSFW job... offer to refer the applicant to any available jobs for which the MSFW may be qualified, and any JS...

20 CFR 653.102 - Job information.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 20 Employees' Benefits 3 2012-04-01 2012-04-01 false Job information. 653.102 Section 653.102... SERVICE SYSTEM Services for Migrant and Seasonal Farmworkers (MSFWs) § 653.102 Job information. All State agencies shall make job order information conspicuous and available to MSFWs in all local offices. This...

20 CFR 653.103 - MSFW job applications.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 20 Employees' Benefits 3 2011-04-01 2011-04-01 false MSFW job applications. 653.103 Section 653... EMPLOYMENT SERVICE SYSTEM Services for Migrant and Seasonal Farmworkers (MSFWs) § 653.103 MSFW job... offer to refer the applicant to any available jobs for which the MSFW may be qualified, and any JS...

20 CFR 653.103 - MSFW job applications.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 20 Employees' Benefits 3 2012-04-01 2012-04-01 false MSFW job applications. 653.103 Section 653... EMPLOYMENT SERVICE SYSTEM Services for Migrant and Seasonal Farmworkers (MSFWs) § 653.103 MSFW job... offer to refer the applicant to any available jobs for which the MSFW may be qualified, and any JS...

20 CFR 653.102 - Job information.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 20 Employees' Benefits 3 2011-04-01 2011-04-01 false Job information. 653.102 Section 653.102... SERVICE SYSTEM Services for Migrant and Seasonal Farmworkers (MSFWs) § 653.102 Job information. All State agencies shall make job order information conspicuous and available to MSFWs in all local offices. This...

20 CFR 653.103 - MSFW job applications.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 20 Employees' Benefits 3 2013-04-01 2013-04-01 false MSFW job applications. 653.103 Section 653... EMPLOYMENT SERVICE SYSTEM Services for Migrant and Seasonal Farmworkers (MSFWs) § 653.103 MSFW job... offer to refer the applicant to any available jobs for which the MSFW may be qualified, and any JS...

20 CFR 653.102 - Job information.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 20 Employees' Benefits 3 2014-04-01 2014-04-01 false Job information. 653.102 Section 653.102... SERVICE SYSTEM Services for Migrant and Seasonal Farmworkers (MSFWs) § 653.102 Job information. All State agencies shall make job order information conspicuous and available to MSFWs in all local offices. This...

20 CFR 653.102 - Job information.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Job information. 653.102 Section 653.102... SERVICE SYSTEM Services for Migrant and Seasonal Farmworkers (MSFWs) § 653.102 Job information. All State agencies shall make job order information conspicuous and available to MSFWs in all local offices. This...

33 CFR 117.653 - St. Mary's Falls Canal.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false St. Mary's Falls Canal. 117.653 Section 117.653 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY BRIDGES DRAWBRIDGE OPERATION REGULATIONS Specific Requirements Michigan § 117.653 St. Mary's Falls Canal. The draw of...

33 CFR 117.653 - St. Mary's Falls Canal.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 33 Navigation and Navigable Waters 1 2011-07-01 2011-07-01 false St. Mary's Falls Canal. 117.653 Section 117.653 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY BRIDGES DRAWBRIDGE OPERATION REGULATIONS Specific Requirements Michigan § 117.653 St. Mary's Falls Canal. The draw of...

33 CFR 117.653 - St. Mary's Falls Canal.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 33 Navigation and Navigable Waters 1 2014-07-01 2014-07-01 false St. Mary's Falls Canal. 117.653 Section 117.653 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY BRIDGES DRAWBRIDGE OPERATION REGULATIONS Specific Requirements Michigan § 117.653 St. Mary's Falls Canal. The draw of...

33 CFR 117.653 - St. Mary's Falls Canal.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 33 Navigation and Navigable Waters 1 2013-07-01 2013-07-01 false St. Mary's Falls Canal. 117.653 Section 117.653 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY BRIDGES DRAWBRIDGE OPERATION REGULATIONS Specific Requirements Michigan § 117.653 St. Mary's Falls Canal. The draw of...

33 CFR 117.653 - St. Mary's Falls Canal.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 33 Navigation and Navigable Waters 1 2012-07-01 2012-07-01 false St. Mary's Falls Canal. 117.653 Section 117.653 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY BRIDGES DRAWBRIDGE OPERATION REGULATIONS Specific Requirements Michigan § 117.653 St. Mary's Falls Canal. The draw of...

47 CFR 73.653 - Operation of TV aural and visual transmitters.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 47 Telecommunication 4 2010-10-01 2010-10-01 false Operation of TV aural and visual transmitters. 73.653 Section 73.653 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) BROADCAST RADIO SERVICES RADIO BROADCAST SERVICES Television Broadcast Stations § 73.653 Operation of TV aural and visual...

20 CFR 653.500 - Purpose and scope of subpart.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Purpose and scope of subpart. 653.500 Section 653.500 Employees' Benefits EMPLOYMENT AND TRAINING ADMINISTRATION, DEPARTMENT OF LABOR SERVICES OF THE EMPLOYMENT SERVICE SYSTEM Agricultural Clearance Order Activity § 653.500 Purpose and scope of subpart. This section contains the requirements...

Arabidopsis Microtubule-Associated Protein MAP65-3 Cross-Links Antiparallel Microtubules toward Their Plus Ends in the Phragmoplast via Its Distinct C-Terminal Microtubule Binding Domain[W

PubMed Central

Ho, Chin-Min Kimmy; Lee, Yuh-Ru Julie; Kiyama, Lindsay D.; Dinesh-Kumar, Savithramma P.; Liu, Bo

2012-01-01

Plant cytokinesis is brought about by the phragmoplast, which contains an antiparallel microtubule (MT) array. The MT-associated protein MAP65-3 acts as an MT-bundling factor that specifically cross-links antiparallel MTs near their plus ends. MAP65 family proteins contain an N-terminal dimerization domain and C-terminal MT interaction domain. Compared with other MAP65 isoforms, MAP65-3 contains an extended C terminus. A MT binding site was discovered in the region between amino acids 496 and 588 and found to be essential for the organization of phragmoplast MTs. The frequent cytokinetic failure caused by loss of MAP65-3 was not rescued by ectopic expression of MAP65-1 under the control of the MAP65-3 promoter, indicating nonoverlapping functions between the two isoforms. In the presence of MAP65-3, however, ectopic MAP65-1 appeared in the phragmoplast midline. We show that MAP65-1 could acquire the function of MAP65-3 when the C terminus of MAP65-3, which contains the MT binding site, was grafted to it. Our results also show that MAP65-1 and MAP65-3 may share redundant functions in MT stabilization. Such a stabilization effect was likely brought about by MT binding and bundling. We conclude that MAP65-3 contains a distinct C-terminal MT binding site with a specific role in cross-linking antiparallel MTs toward their plus ends in the phragmoplast. PMID:22570443

7 CFR 1.653 - How may a party use a deposition in the hearing?

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 1 2010-01-01 2010-01-01 false How may a party use a deposition in the hearing? 1.653 Section 1.653 Agriculture Office of the Secretary of Agriculture ADMINISTRATIVE REGULATIONS Conditions in FERC Hydropower Licenses Hearing, Briefing, and Decision § 1.653 How may a party use a deposition in...

48 CFR 653.219-70 - DOS form DS-1910, Small Business Agency Review-Actions Above the Simplified Acquisition Threshold.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false DOS form DS-1910, Small Business Agency Review-Actions Above the Simplified Acquisition Threshold. 653.219-70 Section 653.219-70 Federal Acquisition Regulations System DEPARTMENT OF STATE CLAUSES AND FORMS FORMS Prescription of Forms 653.219-70 DOS form DS-1910, Small...

48 CFR 653.219-70 - DOS form DS-1910, Small Business Agency Review-Actions Above the Simplified Acquisition Threshold.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 48 Federal Acquisition Regulations System 4 2011-10-01 2011-10-01 false DOS form DS-1910, Small Business Agency Review-Actions Above the Simplified Acquisition Threshold. 653.219-70 Section 653.219-70 Federal Acquisition Regulations System DEPARTMENT OF STATE CLAUSES AND FORMS FORMS Prescription of Forms 653.219-70 DOS form DS-1910, Small...

48 CFR 653.219-70 - DOS form DS-1910, Small Business Agency Review-Actions Above the Simplified Acquisition Threshold.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 48 Federal Acquisition Regulations System 4 2014-10-01 2014-10-01 false DOS form DS-1910, Small Business Agency Review-Actions Above the Simplified Acquisition Threshold. 653.219-70 Section 653.219-70 Federal Acquisition Regulations System DEPARTMENT OF STATE CLAUSES AND FORMS FORMS Prescription of Forms 653.219-70 DOS form DS-1910, Small...

48 CFR 653.219-70 - DOS form DS-1910, Small Business Agency Review-Actions Above the Simplified Acquisition Threshold.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 48 Federal Acquisition Regulations System 4 2013-10-01 2013-10-01 false DOS form DS-1910, Small Business Agency Review-Actions Above the Simplified Acquisition Threshold. 653.219-70 Section 653.219-70 Federal Acquisition Regulations System DEPARTMENT OF STATE CLAUSES AND FORMS FORMS Prescription of Forms 653.219-70 DOS form DS-1910, Small...

E-Learning and Training in Europe: A Survey into the Use of e-Learning in Training and Professional Development in the European Union. CEDEFOP Reference Series.

ERIC Educational Resources Information Center

European Centre for the Development of Vocational Training, Thessaloniki (Greece).

A study investigated the extent of e-learning learning supported by information and communication technologies (ICT) methods in vocational education and training (VET) in the European Union (EU). The survey conducted via the Internet received 653 replies from organizations in the EU. Just over 80 percent of respondents were suppliers or users of…

7 CFR 51.653 - Metric conversion table.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 7 Agriculture 2 2014-01-01 2014-01-01 false Metric conversion table. 51.653 Section 51.653 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE REGULATIONS AND STANDARDS UNDER THE AGRICULTURAL...

7 CFR 51.653 - Metric conversion table.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 7 Agriculture 2 2013-01-01 2013-01-01 false Metric conversion table. 51.653 Section 51.653 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE REGULATIONS AND STANDARDS UNDER THE AGRICULTURAL...

7 CFR 51.653 - Metric conversion table.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 7 Agriculture 2 2012-01-01 2012-01-01 false Metric conversion table. 51.653 Section 51.653 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE REGULATIONS AND STANDARDS UNDER THE AGRICULTURAL...

7 CFR 51.653 - Metric conversion table.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 2 2010-01-01 2010-01-01 false Metric conversion table. 51.653 Section 51.653 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE REGULATIONS AND STANDARDS UNDER THE AGRICULTURAL...

7 CFR 51.653 - Metric conversion table.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 7 Agriculture 2 2011-01-01 2011-01-01 false Metric conversion table. 51.653 Section 51.653 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE REGULATIONS AND STANDARDS UNDER THE AGRICULTURAL...

The Arabidopsis microtubule-associated protein MAP65-3 supports infection by filamentous biotrophic pathogens by down-regulating salicylic acid-dependent defenses.

PubMed

Quentin, Michaël; Baurès, Isabelle; Hoefle, Caroline; Caillaud, Marie-Cécile; Allasia, Valérie; Panabières, Franck; Abad, Pierre; Hückelhoven, Ralph; Keller, Harald; Favery, Bruno

2016-03-01

The oomycete Hyaloperonospora arabidopsidis and the ascomycete Erysiphe cruciferarum are obligate biotrophic pathogens causing downy mildew and powdery mildew, respectively, on Arabidopsis. Upon infection, the filamentous pathogens induce the formation of intracellular bulbous structures called haustoria, which are required for the biotrophic lifestyle. We previously showed that the microtubule-associated protein AtMAP65-3 plays a critical role in organizing cytoskeleton microtubule arrays during mitosis and cytokinesis. This renders the protein essential for the development of giant cells, which are the feeding sites induced by root knot nematodes. Here, we show that AtMAP65-3 expression is also induced in leaves upon infection by the downy mildew oomycete and the powdery mildew fungus. Loss of AtMAP65-3 function in the map65-3 mutant dramatically reduced infection by both pathogens, predominantly at the stages of leaf penetration. Whole-transcriptome analysis showed an over-represented, constitutive activation of genes involved in salicylic acid (SA) biosynthesis, signaling, and defense execution in map65-3, whereas jasmonic acid (JA)-mediated signaling was down-regulated. Preventing SA synthesis and accumulation in map65-3 rescued plant susceptibility to pathogens, but not the developmental phenotype caused by cytoskeleton defaults. AtMAP65-3 thus has a dual role. It positively regulates cytokinesis, thus plant growth and development, and negatively interferes with plant defense against filamentous biotrophs. Our data suggest that downy mildew and powdery mildew stimulate AtMAP65-3 expression to down-regulate SA signaling for infection. © The Author 2016. Published by Oxford University Press on behalf of the Society for Experimental Biology. All rights reserved. For permissions, please email: journals.permissions@oup.com.

20 CFR 653.111 - State agency staffing requirements.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 20 Employees' Benefits 3 2011-04-01 2011-04-01 false State agency staffing requirements. 653.111 Section 653.111 Employees' Benefits EMPLOYMENT AND TRAINING ADMINISTRATION, DEPARTMENT OF LABOR SERVICES... anticipated through expansion, contraction, and turnover in the office(s) and available funds, and all...

7 CFR 653.3 - Adaptation of technical standards.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 6 2010-01-01 2010-01-01 false Adaptation of technical standards. 653.3 Section 653.3 Agriculture Regulations of the Department of Agriculture (Continued) NATURAL RESOURCES CONSERVATION SERVICE... needs. These adaptations must be approved by the Administrator of the Natural Resources Conservation...

20 CFR 653.111 - State agency staffing requirements.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false State agency staffing requirements. 653.111 Section 653.111 Employees' Benefits EMPLOYMENT AND TRAINING ADMINISTRATION, DEPARTMENT OF LABOR SERVICES... anticipated through expansion, contraction, and turnover in the office(s) and available funds, and all...

47 CFR 95.653 - Instructions and warnings.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 47 Telecommunication 5 2013-10-01 2013-10-01 false Instructions and warnings. 95.653 Section 95... PERSONAL RADIO SERVICES Technical Regulations Certification Requirements § 95.653 Instructions and warnings... violation of the rules. (2) Warnings concerning any adjustment that could result in a violation of the rules...

47 CFR 95.653 - Instructions and warnings.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 47 Telecommunication 5 2014-10-01 2014-10-01 false Instructions and warnings. 95.653 Section 95... PERSONAL RADIO SERVICES Technical Regulations Certification Requirements § 95.653 Instructions and warnings... violation of the rules. (2) Warnings concerning any adjustment that could result in a violation of the rules...

47 CFR 95.653 - Instructions and warnings.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 47 Telecommunication 5 2012-10-01 2012-10-01 false Instructions and warnings. 95.653 Section 95... PERSONAL RADIO SERVICES Technical Regulations Certification Requirements § 95.653 Instructions and warnings... violation of the rules. (2) Warnings concerning any adjustment that could result in a violation of the rules...

47 CFR 95.653 - Instructions and warnings.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 47 Telecommunication 5 2011-10-01 2011-10-01 false Instructions and warnings. 95.653 Section 95... PERSONAL RADIO SERVICES Technical Regulations Certification Requirements § 95.653 Instructions and warnings... violation of the rules. (2) Warnings concerning any adjustment that could result in a violation of the rules...

47 CFR 95.653 - Instructions and warnings.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 47 Telecommunication 5 2010-10-01 2010-10-01 false Instructions and warnings. 95.653 Section 95... PERSONAL RADIO SERVICES Technical Regulations Certification Requirements § 95.653 Instructions and warnings... violation of the rules. (2) Warnings concerning any adjustment that could result in a violation of the rules...

7 CFR 400.653 - Determining crops of economic significance.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 6 2010-01-01 2010-01-01 false Determining crops of economic significance. 400.653... Reform, Insurance Implementation § 400.653 Determining crops of economic significance. To be eligible for... of economic significance if the producer does not execute a waiver of any eligibility for emergency...

20 CFR 653.105 - Job applications at day-haul facilities.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 20 Employees' Benefits 3 2012-04-01 2012-04-01 false Job applications at day-haul facilities. 653.105 Section 653.105 Employees' Benefits EMPLOYMENT AND TRAINING ADMINISTRATION, DEPARTMENT OF LABOR... Job applications at day-haul facilities. If the State agency is operating a day-haul facility under...

20 CFR 653.105 - Job applications at day-haul facilities.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 20 Employees' Benefits 3 2011-04-01 2011-04-01 false Job applications at day-haul facilities. 653.105 Section 653.105 Employees' Benefits EMPLOYMENT AND TRAINING ADMINISTRATION, DEPARTMENT OF LABOR... Job applications at day-haul facilities. If the State agency is operating a day-haul facility under...

20 CFR 653.105 - Job applications at day-haul facilities.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 20 Employees' Benefits 3 2014-04-01 2014-04-01 false Job applications at day-haul facilities. 653.105 Section 653.105 Employees' Benefits EMPLOYMENT AND TRAINING ADMINISTRATION, DEPARTMENT OF LABOR... Job applications at day-haul facilities. If the State agency is operating a day-haul facility under...

20 CFR 653.105 - Job applications at day-haul facilities.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 20 Employees' Benefits 3 2013-04-01 2013-04-01 false Job applications at day-haul facilities. 653.105 Section 653.105 Employees' Benefits EMPLOYMENT AND TRAINING ADMINISTRATION, DEPARTMENT OF LABOR... Job applications at day-haul facilities. If the State agency is operating a day-haul facility under...

31 CFR 1010.653 - Special measures against Commercial Bank of Syria.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 31 Money and Finance:Treasury 3 2013-07-01 2013-07-01 false Special measures against Commercial Bank of Syria. 1010.653 Section 1010.653 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) FINANCIAL CRIMES ENFORCEMENT NETWORK, DEPARTMENT OF THE TREASURY GENERAL PROVISIONS...

31 CFR 1010.653 - Special measures against Commercial Bank of Syria.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 31 Money and Finance:Treasury 3 2012-07-01 2012-07-01 false Special measures against Commercial Bank of Syria. 1010.653 Section 1010.653 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) FINANCIAL CRIMES ENFORCEMENT NETWORK, DEPARTMENT OF THE TREASURY GENERAL PROVISIONS...

31 CFR 1010.653 - Special measures against Commercial Bank of Syria.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 31 Money and Finance:Treasury 3 2014-07-01 2014-07-01 false Special measures against Commercial Bank of Syria. 1010.653 Section 1010.653 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) FINANCIAL CRIMES ENFORCEMENT NETWORK, DEPARTMENT OF THE TREASURY GENERAL PROVISIONS...

31 CFR 1010.653 - Special measures against Commercial Bank of Syria.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 31 Money and Finance:Treasury 3 2011-07-01 2011-07-01 false Special measures against Commercial Bank of Syria. 1010.653 Section 1010.653 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) FINANCIAL CRIMES ENFORCEMENT NETWORK, DEPARTMENT OF THE TREASURY GENERAL PROVISIONS...

7 CFR 400.653 - Determining crops of economic significance.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 7 Agriculture 6 2014-01-01 2014-01-01 false Determining crops of economic significance. 400.653... Reform, Insurance Implementation § 400.653 Determining crops of economic significance. To be eligible for... of economic significance if the producer does not execute a waiver of any eligibility for emergency...

7 CFR 400.653 - Determining crops of economic significance.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 7 Agriculture 6 2013-01-01 2013-01-01 false Determining crops of economic significance. 400.653... Reform, Insurance Implementation § 400.653 Determining crops of economic significance. To be eligible for... of economic significance if the producer does not execute a waiver of any eligibility for emergency...

7 CFR 400.653 - Determining crops of economic significance.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 7 Agriculture 6 2011-01-01 2011-01-01 false Determining crops of economic significance. 400.653... Reform, Insurance Implementation § 400.653 Determining crops of economic significance. To be eligible for... of economic significance if the producer does not execute a waiver of any eligibility for emergency...

7 CFR 400.653 - Determining crops of economic significance.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 7 Agriculture 6 2012-01-01 2012-01-01 false Determining crops of economic significance. 400.653... Reform, Insurance Implementation § 400.653 Determining crops of economic significance. To be eligible for... of economic significance if the producer does not execute a waiver of any eligibility for emergency...

20 CFR 653.106 - JS day-haul responsibilities.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false JS day-haul responsibilities. 653.106 Section... THE EMPLOYMENT SERVICE SYSTEM Services for Migrant and Seasonal Farmworkers (MSFWs) § 653.106 JS day... Regional Administrator is obtained. (b) No JS applicants shall be referred to non-JS operated day-haul...

48 CFR 653.200 - Scope of subpart.

Code of Federal Regulations, 2010 CFR

2010-10-01

... same order as and keyed to the parts of the DOSAR in which the form usage requirements are addressed. ... Section 653.200 Federal Acquisition Regulations System DEPARTMENT OF STATE CLAUSES AND FORMS FORMS Prescription of Forms 653.200 Scope of subpart. This subpart prescribes or references optional and DOS forms...

Software Model Checking of ARINC-653 Flight Code with MCP

NASA Technical Reports Server (NTRS)

Thompson, Sarah J.; Brat, Guillaume; Venet, Arnaud

2010-01-01

The ARINC-653 standard defines a common interface for Integrated Modular Avionics (IMA) code. In particular, ARINC-653 Part 1 specifies a process- and partition-management API that is analogous to POSIX threads, but with certain extensions and restrictions intended to support the implementation of high reliability flight code. MCP is a software model checker, developed at NASA Ames, that provides capabilities for model checking C and C++ source code. In this paper, we present recent work aimed at implementing extensions to MCP that support ARINC-653, and we discuss the challenges and opportunities that consequentially arise. Providing support for ARINC-653 s time and space partitioning is nontrivial, though there are implicit benefits for partial order reduction possible as a consequence of the API s strict interprocess communication policy.

The Relationship of Parenting Styles to Commitment to the Church among Young Adults.

ERIC Educational Resources Information Center

Dudley, Roger L.; Wisbey, Randall L.

2000-01-01

Investigates the effects of parenting style experiences during childhood has on the religious commitment of young adults. Surveyed Seventh-day Adventist young adults (n=653) in United States and Canada. Reveals that the affectionate constraint parenting style produced the largest percentage of members. Includes references. (CMK)

40 CFR 415.653 - Effluent limitations guidelines representing the degree of effluent reduction attainable by the...

Code of Federal Regulations, 2012 CFR

2012-07-01

... economically achievable (BAT). 415.653 Section 415.653 Protection of Environment ENVIRONMENTAL PROTECTION... achievable (BAT). Except as provided in 40 CFR 125.30 through 125.32, any existing point source subject to... reduction attainable by the application of the best available technology economically achievable (BAT): The...

40 CFR 415.653 - Effluent limitations guidelines representing the degree of effluent reduction attainable by the...

Code of Federal Regulations, 2011 CFR

2011-07-01

... economically achievable (BAT). 415.653 Section 415.653 Protection of Environment ENVIRONMENTAL PROTECTION... achievable (BAT). Except as provided in 40 CFR 125.30 through 125.32, any existing point source subject to... reduction attainable by the application of the best available technology economically achievable (BAT): The...

40 CFR 415.653 - Effluent limitations guidelines representing the degree of effluent reduction attainable by the...

Code of Federal Regulations, 2010 CFR

2010-07-01

... economically achievable (BAT). 415.653 Section 415.653 Protection of Environment ENVIRONMENTAL PROTECTION... achievable (BAT). Except as provided in 40 CFR 125.30 through 125.32, any existing point source subject to... reduction attainable by the application of the best available technology economically achievable (BAT): The...

20 CFR 653.104 - Services to MSFW family members, farm labor contractors, and crew members.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Services to MSFW family members, farm labor contractors, and crew members. 653.104 Section 653.104 Employees' Benefits EMPLOYMENT AND TRAINING ADMINISTRATION, DEPARTMENT OF LABOR SERVICES OF THE EMPLOYMENT SERVICE SYSTEM Services for Migrant and Seasonal...

30 CFR 285.653 - What other reports or notices must I submit to MMS under my approved GAP?

Code of Federal Regulations, 2011 CFR

2011-07-01

... MMS under my approved GAP? 285.653 Section 285.653 Mineral Resources BUREAU OF OCEAN ENERGY MANAGEMENT, REGULATION, AND ENFORCEMENT, DEPARTMENT OF THE INTERIOR OFFSHORE RENEWABLE ENERGY ALTERNATE USES OF EXISTING... identified measures that were not effective, you must include your recommendations for new mitigation...

42 CFR 65.3 - Who is eligible to apply for a grant?

Code of Federal Regulations, 2011 CFR

2011-10-01

... 42 Public Health 1 2011-10-01 2011-10-01 false Who is eligible to apply for a grant? 65.3 Section 65.3 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES FELLOWSHIPS, INTERNSHIPS, TRAINING NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES HAZARDOUS WASTE WORKER TRAINING § 65...

42 CFR 65.3 - Who is eligible to apply for a grant?

Code of Federal Regulations, 2013 CFR

2013-10-01

... 42 Public Health 1 2013-10-01 2013-10-01 false Who is eligible to apply for a grant? 65.3 Section 65.3 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES FELLOWSHIPS, INTERNSHIPS, TRAINING NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES HAZARDOUS WASTE WORKER TRAINING § 65...

42 CFR 65.3 - Who is eligible to apply for a grant?

Code of Federal Regulations, 2014 CFR

2014-10-01

... 42 Public Health 1 2014-10-01 2014-10-01 false Who is eligible to apply for a grant? 65.3 Section 65.3 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES FELLOWSHIPS, INTERNSHIPS, TRAINING NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES HAZARDOUS WASTE WORKER TRAINING § 65...

42 CFR 65.3 - Who is eligible to apply for a grant?

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 1 2010-10-01 2010-10-01 false Who is eligible to apply for a grant? 65.3 Section 65.3 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES FELLOWSHIPS, INTERNSHIPS, TRAINING NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES HAZARDOUS WASTE WORKER TRAINING § 65...

42 CFR 65.3 - Who is eligible to apply for a grant?

Code of Federal Regulations, 2012 CFR

2012-10-01

... 42 Public Health 1 2012-10-01 2012-10-01 false Who is eligible to apply for a grant? 65.3 Section 65.3 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES FELLOWSHIPS, INTERNSHIPS, TRAINING NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES HAZARDOUS WASTE WORKER TRAINING § 65...

30 CFR 585.653 - What other reports or notices must I submit to BOEM under my approved GAP?

Code of Federal Regulations, 2014 CFR

2014-07-01

... BOEM under my approved GAP? 585.653 Section 585.653 Mineral Resources BUREAU OF OCEAN ENERGY MANAGEMENT, DEPARTMENT OF THE INTERIOR OFFSHORE RENEWABLE ENERGY AND ALTERNATE USES OF EXISTING FACILITIES ON THE OUTER... that were not effective, you must include your recommendations for new mitigation measures or...

30 CFR 585.653 - What other reports or notices must I submit to BOEM under my approved GAP?

Code of Federal Regulations, 2013 CFR

2013-07-01

... BOEM under my approved GAP? 585.653 Section 585.653 Mineral Resources BUREAU OF OCEAN ENERGY MANAGEMENT, DEPARTMENT OF THE INTERIOR OFFSHORE RENEWABLE ENERGY AND ALTERNATE USES OF EXISTING FACILITIES ON THE OUTER... that were not effective, you must include your recommendations for new mitigation measures or...

30 CFR 585.653 - What other reports or notices must I submit to BOEM under my approved GAP?

Code of Federal Regulations, 2012 CFR

2012-07-01

... BOEM under my approved GAP? 585.653 Section 585.653 Mineral Resources BUREAU OF OCEAN ENERGY MANAGEMENT, DEPARTMENT OF THE INTERIOR OFFSHORE RENEWABLE ENERGY AND ALTERNATE USES OF EXISTING FACILITIES ON THE OUTER... that were not effective, you must include your recommendations for new mitigation measures or...

27 CFR 6.53 - Advertising in ballparks, racetracks, and stadiums.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Advertising in ballparks, racetracks, and stadiums. 6.53 Section 6.53 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY LIQUORS âTIED-HOUSEâ Unlawful Inducements Paying for Advertising, Display Or Distribution Service...

MTRETR MAINTENANCE SHOP, TRA653. FLOOR PLAN FOR MEZZANINE: LUNCH AND ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

MTR-ETR MAINTENANCE SHOP, TRA-653. FLOOR PLAN FOR MEZZANINE: LUNCH AND CONFERENCE ROOM, STORAGE AREA, OFFICES FOR FOREMEN, STENOS, ENGINEERS, DISPATCHER, WOMEN'S RESTROOM. HUMMEL HUMMEL & JONES 810-MTR-ETR-653-A-12, 2/1958. INL INDEX NO. 532-0653-00-381-102837, REV. 3. - Idaho National Engineering Laboratory, Test Reactor Area, Materials & Engineering Test Reactors, Scoville, Butte County, ID

48 CFR 653.219-70 - DOS form DS-1910, Small Business Agency Review-Actions Above the Simplified Acquisition Threshold.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 48 Federal Acquisition Regulations System 4 2012-10-01 2012-10-01 false DOS form DS-1910, Small Business Agency Review-Actions Above the Simplified Acquisition Threshold. 653.219-70 Section 653.219-70... Threshold. As prescribed in 619.501(c), DS-1910 is prescribed for use in documenting set-aside decisions...

48 CFR 653.219-71 - DOS form DS-4053, Department of State Mentor-Protégé Program Application.

Code of Federal Regulations, 2010 CFR

2010-10-01

..., Department of State Mentor-Protégé Program Application. 653.219-71 Section 653.219-71 Federal Acquisition...-4053, Department of State Mentor-Protégé Program Application. As prescribed in 619.102-70(i), DS-4053 is prescribed for use in applying for an agreement under the Department of State Mentor-Protégé...

Using Self-Reported Patient Experiences to Understand Patient Burden: Learnings from Digital Patient Communities in Ankylosing Spondylitis.

PubMed

Sunkureddi, Prashanth; Gibson, Dawn; Doogan, Stephen; Heid, John; Benosman, Samir; Park, Yujin

2018-03-01

Online communities contain a wealth of information containing unsolicited patient experiences that may go beyond what is captured by guided surveys or patient-reported outcome (PRO) instruments used in clinical settings. This study described patient experiences reported online to better understand the day-to-day disease burden of ankylosing spondylitis (AS). Unguided, English-language patient narratives reported between January 2010 and May 2016 were collected from 52 online sources (e.g., general/health social networking sites, patient-physician Q&A sites, AS forums). Using natural language processing combined with manual curation, patient-reported experiences within narratives were evaluated and categorized into social, physical, emotional, cognitive, and role activity (SPEC-R) concepts to assess functional impairment. The same SPEC-R categorization was applied to 5 AS-specific PRO instruments to evaluate their coverage of concepts extracted from patient narratives. A total of 34,780 narratives from 3449 patients with AS were included. Physical aspects of AS (e.g., pain and mobility) were most commonly reported by patients (86.7%), followed by emotional (32.5%), cognitive (23.6%), role activity (8.7%) and social (5.1%). Some frequently discussed subconcepts were effectively captured by ≥ 2 PRO instruments, such as pain (65.3%), asthenia (19.9%), musculoskeletal impairment (19.9%), depression (9.9%), and anger/frustration (5.4%); others [e.g., anxiety (19.1%), mental impairment (3.2%), impulsivity (2.9%)] were not addressed by any of the PRO instruments. These findings highlight the importance of analyzing patient experiences beyond clinical trial settings and physician reports; continuous assessment of existing PRO instruments in collaboration with patients may increase their utility in real-world settings. Novartis Pharmaceuticals Corporation.

Recent progress in empirical modeling of ion composition in the topside ionosphere

NASA Astrophysics Data System (ADS)

Truhlik, Vladimir; Triskova, Ludmila; Bilitza, Dieter; Kotov, Dmytro; Bogomaz, Oleksandr; Domnin, Igor

2016-07-01

The last deep and prolonged solar minimum revealed shortcomings of existing empirical models, especially of parameter models that depend strongly on solar activity, such as the IRI (International Reference Ionosphere) ion composition model, and that are based on data sets from previous solar cycles. We have improved the TTS-03 ion composition model (Triskova et al., 2003) which is included in IRI since version 2007. The new model called AEIKion-13 employs an improved description of the dependence of ion composition on solar activity. We have also developed new global models of the upper transition height based on large data sets of vertical electron density profiles from ISIS, Alouette and COSMIC. The upper transition height is used as an anchor point for adjustment of the AEIKion-13 ion composition model. Additionally, we show also progress on improvements of the altitudinal dependence of the ion composition in the AEIKion-13 model. Results of the improved model are compared with data from other types of measurements including data from the Atmosphere Explorer C and E and C/NOFS satellites, and the Kharkiv and Arecibo incoherent scatter radars. Possible real time updating of the model by the upper transition height from the real time COSMIC vertical profiles is discussed. Triskova, L.,Truhlik,V., Smilauer, J.,2003. An empirical model of ion composition in the outer ionosphere. Adv. Space Res. 31(3), 653-663.

Longitudinal 2-point dixon muscle magnetic resonance imaging in becker muscular dystrophy.

PubMed

Bonati, Ulrike; Schmid, Maurice; Hafner, Patricia; Haas, Tanja; Bieri, Oliver; Gloor, Monika; Fischmann, Arne; Fischer, Dirk

2015-06-01

Quantitative MRI techniques detect disease progression in myopathies more sensitively than muscle function measures or conventional MRI. To date, only conventional MRI data using visual rating scales are available for measurement of disease progression in Becker muscular dystrophy (BMD). In 3 patients with BMD (mean age 36.8 years), the mean fat fraction (MFF) of the thigh muscles was assessed by MRI at baseline and at 1-year follow-up using a 2-point Dixon approach (2PD). The motor function measurement scale (MFM) was used for clinical assessment. The mean MFF of all muscles at baseline was 61.6% (SD 7.6). It increased by 3.7% to 65.3% (SD 4.7) at follow-up. The severity of muscle involvement varied between various muscle groups. As in other myopathies, 2PD can quantify fatty muscle degeneration in BMD and can detect disease progression in a small sample size and at relatively short imaging intervals. © 2015 Wiley Periodicals, Inc.

Women in medical education: views and experiences from the Kingdom of Saudi Arabia.

PubMed

Alwazzan, Lulu; Rees, Charlotte E

2016-08-01

Although research from Western contexts suggests that considerable inequalities for female medical educators exist in the workplace, we do not yet know the views and experiences of women within non-Western contexts. By examining the influence of context, intersecting identities and language use, this study explores female medical educators' views and experiences of gender, career progression and leadership in academic medicine in the Kingdom of Saudi Arabia (KSA). We conducted individual interviews employing narrative interviewing techniques with 25 female medical educators from five schools in the KSA (June to December 2014). Data were analysed using framework analysis and drew on intersectionality theory. Participants expressed their views and experiences of career progression, leadership and gendered workplace cultures. Women's experiences of career progression and leadership in the KSA were influenced by their gender and varied according to their career stage, work environment and specialty. Participants discussed the gendered organisational cultures of academic medicine in the KSA in terms of gender inequalities (e.g. females being overlooked for leadership positions), gender stereotypes (e.g. women perceived as more likely to take part in shared leadership) and gendered specialties (e.g. surgery being male dominated). We revealed women's more tacit understandings about gender, career progression and leadership by examining how they talk (e.g. metaphoric, pronominal and emotional talk). Finally, participants constructed multiple intersecting personal (e.g. female, mother and young) and professional identities (e.g. doctor, teacher and leader) for themselves through their narratives. This study provides important new insights into female medical educators' experiences of career progression and leadership in a non-Western context. Investment in the future of women's careers in the KSA through faculty development initiatives and equality and diversity policies is now essential to help close the gender gap. © 2016 John Wiley & Sons Ltd and The Association for the Study of Medical Education.

Moderate folic acid supplementation and MTHFD1-synthetase deficiency in mice, a model for the R653Q variant, result in embryonic defects and abnormal placental development.

PubMed

Christensen, Karen E; Hou, Wenyang; Bahous, Renata H; Deng, Liyuan; Malysheva, Olga V; Arning, Erland; Bottiglieri, Teodoro; Caudill, Marie A; Jerome-Majewska, Loydie A; Rozen, Rima

2016-11-01

Moderately high folic acid intake in pregnant women has led to concerns about deleterious effects on the mother and fetus. Common polymorphisms in folate genes, such as methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase-formyltetrahydrofolate synthetase (MTHFD1) R653Q, may modulate the effects of elevated folic acid intake. We investigated the effects of moderate folic acid supplementation on reproductive outcomes and assessed the potential interaction of the supplemented diet with MTHFD1-synthetase (Mthfd1S) deficiency in mice, which is a model for the R653Q variant. Female Mthfd1S +/+ and Mthfd1S +/- mice were fed a folic acid-supplemented diet (FASD) (5-fold higher than recommended) or control diets before mating and during pregnancy. Embryos and placentas were assessed for developmental defects at embryonic day 10.5 (E10.5). Maternal folate and choline metabolites and gene expression in folate-related pathways were examined. The combination of FASD and maternal MTHFD1-synthetase deficiency led to a greater incidence of defects in E10.5 embryos (diet × maternal genotype, P = 0.0016; diet × embryonic genotype, P = 0.054). The methylenetetrahydrofolate reductase (MTHFR) protein and methylation potential [ratio of S-adenosylmethionine (major methyl donor):S-adenosylhomocysteine) were reduced in maternal liver. Although 5-methyltetrahydrofolate (methylTHF) was higher in maternal circulation, the methylation potential was lower in embryos. The presence of developmental delays and defects in Mthfd1S +/- embryos was associated with placental defects (P = 0.003). The labyrinth layer failed to form properly in the majority of abnormal placentas, which compromised the integration of the maternal and fetal circulation and presumably the transfer of methylTHF and other nutrients. Moderately higher folate intake and MTHFD1-synthetase deficiency in pregnant mice result in a lower methylation potential in maternal liver and embryos and a greater incidence of defects in embryos. Although maternal circulating methylTHF was higher, it may not have reached the embryos because of abnormal placental development; abnormal placentas were observed predominantly in abnormally developed embryos. These findings have implications for women with high folate intakes, particularly if they are polymorphic for MTHFD1 R653Q. © 2016 American Society for Nutrition.

[Hadroproduction of charmed and bottom mesons (Fermilab experiment E-653): Progress report, June 13, 1983--June 14, 1984

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1984-12-31

(I)Results are given for photoproduction of the D{sup *} at 103 GeV. Clean signals are seen for the decay D{sup *{+-}} {yields} {pi}{sup {+-}}D{sup 0} with the D{sup 0} decaying into both K{sup {-+}}{pi}{sup {+-}} and K{sup {-+}}{pi}{sup {+-}}{pi}{sup 0}. Analysis of the Dalitz plot for the K{pi}{pi} mode gives branching fractions (BFs) for K{sup {minus}}{rho}{sup +}, K{sup *{minus}}{pi}{sup +}, and {anti K}{sup *0}{pi}{sup 0} final states. The BF for D{sup 0} {yields} K{sup {minus}}{rho}{sup +}, much lower than a previous result, is in approximate agreement with the value expected for an l=1/2 final state. (II)Inelastic and elastic J/{psi} photoproductionmore » on H is investigated at 103 GeV. The inelastic cross section with E{sub {psi}}/E{sub {gamma}} {lt} 0.9 is significantly lower than the corresponding result for muoproduction on Fe targets, but consistent with second-order perturbative QCD calculation. The mean p{sub +} of inelastic events is larger than that of elastic events. (III)Analysis of data from the CLEO experiment has yielded evidence for B{bar B} production from the 4S upsilon state. A preliminary cross section is shown. (IV)The SSD prototyping and testing program is described. The detectors performed as expected. (V)Three 24 x 36 mm{sup 2} Centronic detectors 300 microns thick were tested in 650-MeV/c proton and 600-MeV/c pion beams. Charge sharing was found to occur. (VI)Tests of attenuation lengths and light output were made on three types of scintillator: NE102A, PS12, and PS10. PS10 appears the most suitable. (VII)Charge-sharing SSDs of (V) were subject to analysis: checking of pulse heights of single stripes, hit pairs, and hit quads vs theoretical values; resolution of three-point proton/pion tracks, and characterization of devices by charge sum/difference plots of hit pairs. (VIII) Board fabrication and tests of a hadron calorimeter intended to be 91 x 91 sq.in. are discussed. (IX)Testing of an amplifier with LRS hybrid preamp is related.« less

MTRETR MAINTENANCE SHOP, TRA653. FLOOR PLAN FOR FIRST FLOOR: MACHINE ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

MTR-ETR MAINTENANCE SHOP, TRA-653. FLOOR PLAN FOR FIRST FLOOR: MACHINE SHOP, ELECTRICAL AND INSTRUMENT SHOP, TOOL CRIB, ELECTRONIC SHOP, LOCKER ROOM, SPECIAL TEMPERATURE CONTROLLED ROOM, AND OFFICES. "NEW" ON DRAWING REFERS TO REVISION OF 11/1956 DRAWING ON WHICH AREAS WERE DESIGNATED AS "FUTURE." HUMMEL HUMMEL & JONES 810-MTR-ETR-653-A-7, 5/1957. INL INDEX NO. 532-0653-00-381-101839, REV. 2. - Idaho National Engineering Laboratory, Test Reactor Area, Materials & Engineering Test Reactors, Scoville, Butte County, ID

DOE Office of Scientific and Technical Information (OSTI.GOV)

Stanislaus, Shirvel; Manweiler, Robert; Koetke, Donald

This report summarizes the research carried out by the faculty, staff and students of Valparaiso University (VU) during the 30-year period from 1986 to 2015 using funds provided by the Medium Energy Nuclear Physics program of the Department of Energy (DOE). Three faculty members led the VU research group during the lifetime of the research grant. The three principal investigators responsible for the research were: Dr. Donald Koetke (1986 – 2007), Dr. Robert Manweiler (2008 – 2010), and Dr. Shirvel Stanislaus (2011 – 2015). During this period we participated and contributed to the progress of the following experiments: 1. Themore » MEGA Experiment at Los Alamos National Laboratory (LAMPF E969). 2. The Crystal Ball Experiment at Brookhaven National Laboratory (BNL/AGS E906, E913). 3. The NuSea Experiment at Fermilab (FNAL E866). 4. The TWIST Experiment at TRIUMF (TRIUMF E614). 5. The STAR Experiment at RHIC. 6. The nEDM Experiment at Oak Ridge National Laboratory. In the following sections we briefly describe the goals of the above experiments and the contributions made by the Valparaiso University personnel towards the progress of each project.« less

Condition Monitoring Techniques for Electromechanical Equipment Used in Air Force Ground C3I (Command, Control, Communications and Intelligence) Systems.

DTIC Science & Technology

1983-08-01

Proc. 2nd Congress National de flabilite, Perros -Guirec, Sept. 17-20, 1974, pp. 639-653. Published by CNET, Lannion (France). 53. Love, A. E. H., A...96. C. Rosiaux, Fiabilite des allumeurs determinee a partir des ventes-echanges, Proc. 2nd Congres National de fiabilite, Perros Guirec, Sept. 17-20

44 CFR 65.3 - Requirement to submit new technical data.

Code of Federal Regulations, 2011 CFR

2011-10-01

... available, a community shall notify the Administrator of the changes by submitting technical or scientific... IDENTIFICATION AND MAPPING OF SPECIAL HAZARD AREAS § 65.3 Requirement to submit new technical data. A community's...

Critique of FY 1984 Advertising Mix Test of Wharton Center for Applied Research.

DTIC Science & Technology

1986-09-01

experiment and the selection of ADIs for the Reduced advertising Cells in the 1979 Navy Enlistment Marketing Experiment (reported in Marketing Science...AD-Ai?3 653 CRITIQUE OF FY 1984 ADVERTISING NIX TEST OF MHARTON i/1 CENTER FOR APPLIED RE..(U) TEXAS UNIV AT AUSTIN CENTER FOR CYBERNETIC STUDIES A...L4 11.6 M)CROCOPY RESOLUTION TEST CHART NA1I0NAL BUREAU Of SOANDARDS, I%3-A .A ’~A~ J ~. Research Report CCS 546 CRITIQUE OF FY 1984 ADVERTISING MIX

31 CFR Appendix to Part 321 - Appendix to Department of the Treasury Circular No. 750, Fourth Revision

Code of Federal Regulations, 2011 CFR

2011-07-01

... publications: (a) Offering circulars. Department of the Treasury Circulars, Public Debt Series Nos. 1-80 (31 CFR part 351, Series EE bonds), 2-80 (31 CFR part 352, Series HH bonds), 1-98 (31 CFR part 359, Series.... 653 (31 CFR part 316, Series E bonds) and 905 (31 CFR part 339, Series H bonds). (b) Regulations...

50 CFR 17.108 - List of designated manatee protection areas.

Code of Federal Regulations, 2010 CFR

2010-10-01

..., a distance of approximately 0.3 kilometers (0.2 miles) in length, watercraft are required to proceed... 1240 feet to Corner 2 (N-1,653,762/E/309,641) a point; thence S. 56°58′11″ W., across open water, 776... Island Sanctuary. (2) That part of Kings Bay, Crystal River, Citrus County, Florida, within T. 18 S., R...

U.C. Davis high energy particle physics research: Technical progress report -- 1990

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

Summaries of progress made for this period is given for each of the following areas: (1) Task A--Experiment, H1 detector at DESY; (2) Task C--Experiment, AMY detector at KEK; (3) Task D--Experiment, fixed target detectors at Fermilab; (4) Task F--Experiment, PEP detector at SLAC and pixel detector; (5) Task B--Theory, particle physics; and (6) Task E--Theory, particle physics.

Survey of Key Informants on Elder Abuse and Neglect: Report to the Texas Senate Select Subcommittee on Elder Abuse, 70th Legislative Session.

ERIC Educational Resources Information Center

Anderson, Jeffrey M.; Theiss, John T.

This document reports the findings of a study conducted for the Texas legislature to use in evaluating alternatives for dealing with elder abuse. The described study analyzed experiences with elder abuse of 1,653 Texas professionals in the fields of health and medicine, the judiciary, financial services, law enforcement, and social services. The…

Mechanism of solid-state plasma-induced dewetting for formation of copper and gold nanoparticles.

PubMed

Kwon, Soon-Ho; Choe, Han Joo; Lee, Hyo-Chang; Chung, Chin-Wook; Lee, Jung-Joong

2013-09-01

Cu and Au nanoparticles were fabricated by plasma treatment on Cu and Au films at 653 K. The nanoparticles were formed by dewetting the metallic films using plasma. Scanning electron microscopy and transmission electron microscopy investigations showed that the plasma-induced dewetting of the Cu and Au films proceeded through heterogeneous hole nucleation and growth along the grain boundaries to lower the surface energy. The amount of energy transferred to surface atoms by one Ar ion was calculated to be 16.1 eV, which was sufficient for displacing Cu and Au atoms. Compared to thermally activated dewetting, more uniform particles could be obtained by plasma-induced dewetting because a much larger number of holes with smaller sizes was generated. The plasma dewetting process is less sensitive to the oxidation of metallic films compared to the annealing process. As a result, Cu nanoparticles could be fabricated at 653 K, whereas the thermally activated dewetting was not possible.

Department of the Navy Justification of Estimates for Fiscal Year 1983 Submitted to Congress February 1982. Research, Development, Test and Evaluation: Research, Development, Test and Evaluation, Navy.

DTIC Science & Technology

1982-02-01

Improvements to and Construction of Government -Owned Facilities Funded by RDT&E -------------------- 57 Section 8: Project Data for Construction at... Government -Owned Facilities Funded by RDT&E --------------------------. . Section 9: Flight Simulator Programs...653,427 936.167 29 63202N AVIONICS 2 3,314 3,745 3,622 10,342 U 407 26 632n3N A0V HELICOPTER DEV 2 4,577 4,790 U 27 63207N ENVIRONENTAL APPLICATIONS 2

Project CHECO Southeast Asia Report. Igloo White (Initial Phase)

DTIC Science & Technology

1968-07-31

sensors--had to be developed, tested, and produced in quantity. A wing of EC-121 aircraft had to be deployed to Korat RTAFB, Thailand, to provide orbital...Location (Thailand) 653d Recon Wg 21 EC-121 Korat 1st Air Commando Wg 19 Al-E Nakhon Phanom 21st Helicopter Sq 12 CH-3E Nakhon Phanom 23d Tac Air Spt Sq...tinual orbits over the sensor fields. These aircraft based at Korat , m normally flew in orbit for eight hours, or until relieved by a replacement

ETRMTR MECHANICAL SERVICES BUILDING, TRA653. CAMERA FACING NORTHWEST AS BUILDING ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

ETR-MTR MECHANICAL SERVICES BUILDING, TRA-653. CAMERA FACING NORTHWEST AS BUILDING WAS NEARLY COMPLETE. INL NEGATIVE NO. 57-3653. K. Mansfield, Photographer, 7/22/1957 - Idaho National Engineering Laboratory, Test Reactor Area, Materials & Engineering Test Reactors, Scoville, Butte County, ID

Integrity of Narrow Epithelial Tubes in the C. elegans Excretory System Requires a Transient Luminal Matrix

PubMed Central

Ayala-Figueroa, Jesus; Parry, Jean M.; Pu, Pu; Hall, David H.

2016-01-01

Most epithelial cells secrete a glycoprotein-rich apical extracellular matrix that can have diverse but still poorly understood roles in development and physiology. Zona Pellucida (ZP) domain glycoproteins are common constituents of these matrices, and their loss in humans is associated with a number of diseases. Understanding of the functions, organization and regulation of apical matrices has been hampered by difficulties in imaging them both in vivo and ex vivo. We identified the PAN-Apple, mucin and ZP domain glycoprotein LET-653 as an early and transient apical matrix component that shapes developing epithelia in C. elegans. LET-653 has modest effects on shaping of the vulva and epidermis, but is essential to prevent lumen fragmentation in the very narrow, unicellular excretory duct tube. We were able to image the transient LET-653 matrix by both live confocal imaging and transmission electron microscopy. Structure/function and fluorescence recovery after photobleaching studies revealed that LET-653 exists in two separate luminal matrix pools, a loose fibrillar matrix in the central core of the lumen, to which it binds dynamically via its PAN domains, and an apical-membrane-associated matrix, to which it binds stably via its ZP domain. The PAN domains are both necessary and sufficient to confer a cyclic pattern of duct lumen localization that precedes each molt, while the ZP domain is required for lumen integrity. Ectopic expression of full-length LET-653, but not the PAN domains alone, could expand lumen diameter in the developing gut tube, where LET-653 is not normally expressed. Together, these data support a model in which the PAN domains regulate the ability of the LET-653 ZP domain to interact with other factors at the apical membrane, and this ZP domain interaction promotes expansion and maintenance of lumen diameter. These data identify a transient apical matrix component present prior to cuticle secretion in C. elegans, demonstrate critical roles for this matrix component in supporting lumen integrity within narrow bore tubes such as those found in the mammalian microvasculature, and reveal functional importance of the evolutionarily conserved ZP domain in this tube protecting activity. PMID:27482894

20 CFR 653.107 - Outreach.

Code of Federal Regulations, 2012 CFR

2012-04-01

... of complaints to the local office complaint specialist or local officer manager; (v) Referral to... office manager for processing in accordance with § 653.113. (l) Outreach workers shall be trained in... local office manager and maintained on file for at least two years. These records shall include the...

20 CFR 653.107 - Outreach.

Code of Federal Regulations, 2013 CFR

2013-04-01

... of complaints to the local office complaint specialist or local officer manager; (v) Referral to... office manager for processing in accordance with § 653.113. (l) Outreach workers shall be trained in... local office manager and maintained on file for at least two years. These records shall include the...

20 CFR 653.107 - Outreach.

Code of Federal Regulations, 2014 CFR

2014-04-01

... of complaints to the local office complaint specialist or local officer manager; (v) Referral to... office manager for processing in accordance with § 653.113. (l) Outreach workers shall be trained in... local office manager and maintained on file for at least two years. These records shall include the...

20 CFR 653.107 - Outreach.

Code of Federal Regulations, 2011 CFR

2011-04-01

... of complaints to the local office complaint specialist or local officer manager; (v) Referral to... office manager for processing in accordance with § 653.113. (l) Outreach workers shall be trained in... local office manager and maintained on file for at least two years. These records shall include the...

7 CFR 1717.653 - Borrowers in default.

Code of Federal Regulations, 2010 CFR

2010-01-01

..., to be in the financial interest of the government with respect to loan security and/or repayment. If... AGRICULTURE POST-LOAN POLICIES AND PROCEDURES COMMON TO INSURED AND GUARANTEED ELECTRIC LOANS Investments, Loans, and Guarantees by Electric Borrowers § 1717.653 Borrowers in default. Any borrower not in...

43 CFR 6.53 - Unpatented inventions.

Code of Federal Regulations, 2013 CFR

2013-10-01

... Public Lands: Interior Office of the Secretary of the Interior PATENT REGULATIONS Licenses § 6.53... by the Secretary of the Interior, and the assignment has been recorded in the Patent Office; and (c... are not yet patented. In order to protect the patent rights of the Department, for the eventual...

20 CFR 653.105 - Job applications at day-haul facilities.

Code of Federal Regulations, 2010 CFR

2010-04-01

... SERVICES OF THE EMPLOYMENT SERVICE SYSTEM Services for Migrant and Seasonal Farmworkers (MSFWs) § 653.105... distributed and a full application shall be completed whenever an MSFW requests the opportunity to file a full... earliest practical time. In all other cases, a list of JS services shall be distributed. ...

43 CFR 6.53 - Unpatented inventions.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Public Lands: Interior Office of the Secretary of the Interior PATENT REGULATIONS Licenses § 6.53... by the Secretary of the Interior, and the assignment has been recorded in the Patent Office; and (c... are not yet patented. In order to protect the patent rights of the Department, for the eventual...

43 CFR 6.53 - Unpatented inventions.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Public Lands: Interior Office of the Secretary of the Interior PATENT REGULATIONS Licenses § 6.53... by the Secretary of the Interior, and the assignment has been recorded in the Patent Office; and (c... are not yet patented. In order to protect the patent rights of the Department, for the eventual...

43 CFR 6.53 - Unpatented inventions.

Code of Federal Regulations, 2014 CFR

2014-10-01

... Public Lands: Interior Office of the Secretary of the Interior PATENT REGULATIONS Licenses § 6.53... by the Secretary of the Interior, and the assignment has been recorded in the Patent Office; and (c... are not yet patented. In order to protect the patent rights of the Department, for the eventual...

43 CFR 6.53 - Unpatented inventions.

Code of Federal Regulations, 2012 CFR

2012-10-01

... Public Lands: Interior Office of the Secretary of the Interior PATENT REGULATIONS Licenses § 6.53... by the Secretary of the Interior, and the assignment has been recorded in the Patent Office; and (c... are not yet patented. In order to protect the patent rights of the Department, for the eventual...

Ada (Trade Name) Bibliography. Volume 3.

DTIC Science & Technology

1986-02-01

EXPERIENCES IN TEACHING ADA CAVERLY. PHILIP ; DROCEA, CHARLES; GOLDSTEIN, PHILIP ; YEE, DONALD DOCUMENT NUMBER: 5523 TYPE: PAPER PROCEED. OF THE 2ND ANNUAL CONF...BABEL, PHILIP S. DOCUMENT NUMBER: b653 TYPE: PAPER WASHINGTON ADA SYMPOSIUM, 󈨘 MARCH, PP. 15-18 Motivated by the high cost of mission-critical...CLARA, CA 95052 3611 -01 HARDWARE COMES TO THE AID OF MODULAR HIGH-LEVEL LANGUAGES BABEL, PHILIPS ., U.S.A.F. ASD,WRIGHT-PATTERSON AFB, OH 5653 -03 JOINT

20 CFR 410.653 - Vacation of dismissal of request for hearing.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Vacation of dismissal of request for hearing... Determinations, Administrative Review, Finality of Decisions, and Representation of Parties § 410.653 Vacation of... and for good cause shown, vacate any dismissal of a request for hearing at any time within 60 days...

20 CFR 410.653 - Vacation of dismissal of request for hearing.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 20 Employees' Benefits 2 2011-04-01 2011-04-01 false Vacation of dismissal of request for hearing... Determinations, Administrative Review, Finality of Decisions, and Representation of Parties § 410.653 Vacation of... and for good cause shown, vacate any dismissal of a request for hearing at any time within 60 days...

20 CFR 653.501 - Requirements for accepting and processing clearance orders.

Code of Federal Regulations, 2011 CFR

2011-04-01

..., DEPARTMENT OF LABOR SERVICES OF THE EMPLOYMENT SERVICE SYSTEM Agricultural Clearance Order Activity § 653.501... function of the job service as a no-fee labor exchange, that is, as a forum for bringing together employers... referred through the clearance system shall be notified to contact a local job service office, preferably...

20 CFR 653.501 - Requirements for accepting and processing clearance orders.

Code of Federal Regulations, 2010 CFR

2010-04-01

..., DEPARTMENT OF LABOR SERVICES OF THE EMPLOYMENT SERVICE SYSTEM Agricultural Clearance Order Activity § 653.501... function of the job service as a no-fee labor exchange, that is, as a forum for bringing together employers... referred through the clearance system shall be notified to contact a local job service office, preferably...

20 CFR 653.101 - Provision of services to migrant and seasonal farmworkers (MSFWs).

Code of Federal Regulations, 2010 CFR

2010-04-01

... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Provision of services to migrant and seasonal..., DEPARTMENT OF LABOR SERVICES OF THE EMPLOYMENT SERVICE SYSTEM Services for Migrant and Seasonal Farmworkers (MSFWs) § 653.101 Provision of services to migrant and seasonal farmworkers (MSFWs). (a) Each State...

Antioxidant capacity of BO-653, 2,3-dihydro-5-hydroxy-4,6-di-tert-butyl-2,2-dipentylbenzofuran, and uric acid as evaluated by ORAC method and inhibition of lipid peroxidation.

PubMed

Niki, Etsuo; Fukuhara, Akiko; Omata, Yo; Saito, Yoshiro; Yoshida, Yasukazu

2008-04-01

The role of radical-scavenging antioxidant against oxidative stress has received much attention. The antioxidant capacity has been assessed by various methods. Above all, oxygen radical absorbance capacity (ORAC) has been frequently employed [Prior et.al., J. Agric. Food Chem.2005, 53, 4290]. In the present study, the antioxidant capacity of 2,3-dihydro-5-hydroxy-4,6-di-tert-butyl-2,2-dipentylbenzofuran (BO-653) and uric acid was assessed by ORAC method using pyranine as a reference probe and compared with that against lipid peroxidation of human plasma. It was found that BO-653 was assessed to be much less potent than uric acid by ORAC method, whereas BO-653 exerted much higher antioxidant activity than uric acid against plasma lipid peroxidation. The reason for such discrepancy is discussed. The results suggest that ORAC method is suitable for the assessment of free radical scavenging capacity, but not for the assessment of antioxidant capacity against lipid peroxidation in plasma.

Molecular characterization of phytoplankton dissolved organic matter (DOM) and sulfur components using high resolution Orbitrap mass spectrometry.

PubMed

Mangal, Vaughn; Stock, Naomi L; Guéguen, Celine

2016-03-01

Orbitrap high resolution mass spectrometry (HRMS) with electrospray ionization in both positive and negative polarity was conducted on Suwannee River fulvic acid (SRFA), Pony Lake fulvic acid (PLFA) standards, and dissolved organic matter (DOM) released by freshwater phytoplankton (Scenedesmus obliquus, Euglena mutabilis, and Euglena gracilis). Three-dimensional van Krevelen diagrams expressing various oxygenation states of sulfur molecules and abundance plots of sulfur-containing species were constructed. Orbitrap HRMS analysis of SRFA found a high density of peaks in the lignin region (77 %) and low density of protein material (6.53 %), whereas for PLFA, 25 % of the total peaks were lignin related compared to 56 % of peaks in protein regions, comparable with other HRMS studies. Phytoplankton-derived DOM of S. obliquus, E. mutabilis, and E. gracilis was dominated by protein molecules at respective percentages of 36, 46, and 49 %, and is consistent with previous experiments examining phytoplankton-derived DOM composition. The normalized percentage of SO-containing compounds was determined among the three phytoplankton to be 56 % for Scenedesmus, 54 % for E. mutabilis, and 47 % for E. gracilis, suggesting variation between sulfur content in phytoplankton-derived DOM and differences in metal binding capacities. These results suggest the level of resolution by Orbitrap mass spectrometry is sufficient for preliminary characterization of phytoplankton DOM at an affordable cost relative to other HRMS techniques.

Influence of the overfire air ratio on the NO(x) emission and combustion characteristics of a down-fired 300-MW(e) utility boiler.

PubMed

Ren, Feng; Li, Zhengqi; Chen, Zhichao; Fan, Subo; Liu, Guangkui

2010-08-15

Down-fired boilers used to burn low-volatile coals have high NO(x) emissions. To find a way of solving this problem, an overfire air (OFA) system was introduced on a 300 MW(e) down-fired boiler. Full-scale experiments were performed on this retrofitted boiler to explore the influence of the OFA ratio (the mass flux ratio of OFA to the total combustion air) on the combustion and NO(x) emission characteristics in the furnace. Measurements were taken of gas temperature distributions along the primary air and coal mixture flows, average gas temperatures along the furnace height, concentrations of gases such as O(2), CO, and NO(x) in the near-wall region and carbon content in the fly ash. Data were compared for five different OFA ratios. The results show that as the OFA ratio increases from 12% to 35%, the NO(x) emission decreases from 1308 to 966 mg/Nm(3) (at 6% O(2) dry) and the carbon content in the fly ash increases from 6.53% to 15.86%. Considering both the environmental and economic effect, 25% was chosen as the optimized OFA ratio.

Radiographic Severity of Rheumatoid Arthritis in African-Americans: Results from the CLEAR Registry

PubMed Central

Bridges, S. Louis; Causey, Zenoria L.; Burgos, Paula I.; Huynh, B. Quynh N.; Hughes, Laura B.; Danila, Maria I.; van Everdingen, Amalia; Ledbetter, Stephanie; Conn, Doyt L.; Tamhane, Ashutosh; Westfall, Andrew O.; Jonas, Beth L.; Callahan, Leigh F.; Smith, Edwin A.; Brasington, Richard; Moreland, Larry W.; Alarcón, Graciela S.; van der Heijde, Désirée M.

2010-01-01

Objective To describe radiographic changes in African-Americans with rheumatoid arthritis (RA) from the CLEAR (Consortium for the Longitudinal Evaluation of African-Americans with Early Rheumatoid Arthritis) Registry, a multicenter observational study. Methods Self-declared African-American patients, were enrolled in CLEAR I, a longitudinal cohort of early RA (disease duration <2 years) from 2000 to 2005; or in CLEAR II, a cross-sectional cohort (any disease duration), from 2006 to the present. Demographic and clinical data were obtained, and sets of hand/wrist and foot radiographs were scored using the modified Sharp/van der Heijde scoring system. Results A total of 357 and 418 patients, respectively, have been enrolled into CLEAR I and CLEAR II. We report here an interim analysis of radiographic severity in these patients. For the CLEAR I cohort, 294 patients had a mean radiographic score of 2.89 at the baseline visit; 32.0% showed either erosions (25.9%) or joint space narrowing (JSN) (19.4%). At the 36-month visit the mean score was 5.65; 44.2% had erosions, 41.5% JSN and 55.4% had either. Among those patients without radiographic damage at baseline, 18.9% had progressed at the 36-month visit, compared to 57.1% of those with baseline damage (p<0.0001). For the CLEAR II cohort, 167 patients with RA of any duration, 65.3% exhibited joint erosions, 65.3% JSN and 74.8% exhibited either. The mean radiographic score was 33.42. Conclusion This is the largest radiographic study of African American RA patients. Damage occurs early in the disease and is associated with radiographic progression at 3 years of disease duration. The CLEAR Registry will provide a valuable resource for future analyses of genetic, clinical, and environmental factors associated with radiographic severity of RA in African-Americans. PMID:20461784

Loss-of-function mutations in the thyrotropin receptor gene as a major determinant of hyperthyrotropinemia in a consanguineous community.

PubMed

Tenenbaum-Rakover, Yardena; Grasberger, Helmut; Mamanasiri, Sunee; Ringkananont, Usanee; Montanelli, Lucia; Barkoff, Marla S; Dahood, Ahmad Mahameed-Hag; Refetoff, Samuel

2009-05-01

Resistance to TSH (RTSH) is a condition of impaired responsiveness of the thyroid gland to TSH, characterized by elevated serum TSH, low or normal thyroid hormone levels, and hypoplastic or normal-sized thyroid gland. The aim of the study was to evaluate the clinical course and the genotype-phenotype relationship of RTSH caused by two different TSH receptor (TSHR) gene mutations in a consanguineous population. We conducted a clinical and genetic investigation of 46 members of an extended family and 163 individuals living in the same town. In vitro functional studies of the mutant TSHRs were also performed. Two TSHR gene mutations (P68S and L653V) were identified in 33 subjects occurring as homozygous L653V (five subjects), heterozygous L653V (20 subjects), heterozygous P68S (four subjects), and compound heterozygous L653V/P68S (four subjects). With the exception of one individual with concomitant autoimmune thyroid disease, all homozygotes and compound heterozygotes presented with compensated RTSH (high TSH with free T(4) and T(3) in the normal range). Only nine of 24 heterozygotes had mild hyperthyrotropinemia. The L653V mutation resulted in a higher serum TSH concentration and showed a more severe in vitro abnormality than P68S. Haplotype analysis predicted a founder of the L653V six to seven generations earlier, whereas the P68S is older. Cross-sectional and prospective longitudinal studies indicate that TSH and T(4) concentrations remain stable over time. High frequency hyperthyrotropinemia in an Israeli Arab-Muslim consanguineous community is attributed to two inactivating TSHR gene mutations. Concordant genotype-phenotype was demonstrated clinically and by in vitro functional analysis. Retrospective and prospective studies indicate that in the absence of concomitant autoimmune thyroid disease, elevated TSH levels reflect stable compensated RTSH.

14 CFR 29.653 - Pressure venting and drainage of rotor blades.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Pressure venting and drainage of rotor... § 29.653 Pressure venting and drainage of rotor blades. (a) For each rotor blade— (1) There must be means for venting the internal pressure of the blade; (2) Drainage holes must be provided for the blade...

14 CFR 27.653 - Pressure venting and drainage of rotor blades.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Pressure venting and drainage of rotor....653 Pressure venting and drainage of rotor blades. (a) For each rotor blade— (1) There must be means for venting the internal pressure of the blade; (2) Drainage holes must be provided for the blade; and...

ETRMTR MECHANICAL SERVICES BUILDING, TRA653, INTERIOR. CAMERA IS INSIDE MEN'S ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

ETR-MTR MECHANICAL SERVICES BUILDING, TRA-653, INTERIOR. CAMERA IS INSIDE MEN'S LAVATORY AND SHOWER FACING SOUTHEAST. SHOWER AND TOILET STALLS ARE IN PLACE. ROUND COMMUNAL SINK AT LEFT. INL NEGATIVE NO. 57-3652. K. Mansfield, Photographer, 7/22/1957 - Idaho National Engineering Laboratory, Test Reactor Area, Materials & Engineering Test Reactors, Scoville, Butte County, ID

20 CFR 653.112 - State agency program budget plans.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false State agency program budget plans. 653.112... State agency program budget plans. (a) Each State agency, in its annual program budget plan, shall... and Budget under control number 1205-0039) (Pub. L. No. 96-511, 94 Stat. 2812 (44 U.S.C. 3501 et seq...

FAILSAFE Health Management for Embedded Systems

NASA Technical Reports Server (NTRS)

Horvath, Gregory A.; Wagner, David A.; Wen, Hui Ying; Barry, Matthew

2010-01-01

The FAILSAFE project is developing concepts and prototype implementations for software health management in mission- critical, real-time embedded systems. The project unites features of the industry-standard ARINC 653 Avionics Application Software Standard Interface and JPL s Mission Data System (MDS) technology (see figure). The ARINC 653 standard establishes requirements for the services provided by partitioned, real-time operating systems. The MDS technology provides a state analysis method, canonical architecture, and software framework that facilitates the design and implementation of software-intensive complex systems. The MDS technology has been used to provide the health management function for an ARINC 653 application implementation. In particular, the focus is on showing how this combination enables reasoning about, and recovering from, application software problems.

40 CFR 471.92 - Effluent limitations representing the degree of effluent reduction attainable by the application...

Code of Federal Regulations, 2011 CFR

2011-07-01

... Chromium 0.104 0.043 Cyanide 0.069 0.029 Nickel 0.455 0.301 Ammonia 31.6 13.9 Fluoride 14.1 6.26 (e... monthly average mg/off-kg (pounds per million off-pounds) of zirconium-hafnium heat treated Chromium 0.015... Chromium 0.150 0.061 Cyanide 0.099 0.041 Nickel 0.653 0.432 Ammonia 45.3 20 Fluoride 20.3 8.98 (i) Surface...

40 CFR 471.92 - Effluent limitations representing the degree of effluent reduction attainable by the application...

Code of Federal Regulations, 2010 CFR

2010-07-01

... Chromium 0.104 0.043 Cyanide 0.069 0.029 Nickel 0.455 0.301 Ammonia 31.6 13.9 Fluoride 14.1 6.26 (e... monthly average mg/off-kg (pounds per million off-pounds) of zirconium-hafnium heat treated Chromium 0.015... Chromium 0.150 0.061 Cyanide 0.099 0.041 Nickel 0.653 0.432 Ammonia 45.3 20 Fluoride 20.3 8.98 (i) Surface...

Consumer Products Advertised to Save Energy--Let the Buyer Beware.

DTIC Science & Technology

1981-07-24

AD-AL06 653 GENERAL ACCOUNTING OFFICE WASHINGTON DC HUMAN RESOUR--ETC F/G 5/3 CONSUMER PRODUCTS ADVERTISED TO SAVE ENERGY--LET THE BUYER BEWA-ETC...COMPTROLLER GENERAL’S CONSUMER PRODUCTS ADVERTISED REPORT TO THE CONGRESS TO SAVE ENERGY- - LET THE BUYER BEWARE D IG E ST In efforts to reduce energy costs...Federal and State efforts to protect consumers from inaccurate or misleading claims. GAO noted hundreds of advertisements having ques- tionable

STS-42 Commander Grabe uses DTO 653 MK1 Rowing Machine on OV-103's middeck

NASA Technical Reports Server (NTRS)

1992-01-01

STS-42 Commander Ronald J. Grabe exercises using MK1 Rowing Machine on the middeck of Discovery, Orbiter Vehicle (OV) 103. Grabe is using the exercise device as part of Development Test Objective (DTO) 653, Evaluation of MK1 Rowing Machine. The forward lockers appear at Grabe's right and the sleep station behind him.

40 CFR 59.653 - How do I test portable fuel containers?

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 6 2012-07-01 2012-07-01 false How do I test portable fuel containers... Families § 59.653 How do I test portable fuel containers? You must test the portable fuel container as.... Perform a slosh test by filling the portable fuel container to 40 percent of its capacity with the fuel...

40 CFR 59.653 - How do I test portable fuel containers?

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 6 2013-07-01 2013-07-01 false How do I test portable fuel containers... Families § 59.653 How do I test portable fuel containers? You must test the portable fuel container as.... Perform a slosh test by filling the portable fuel container to 40 percent of its capacity with the fuel...

40 CFR 59.653 - How do I test portable fuel containers?

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 6 2014-07-01 2014-07-01 false How do I test portable fuel containers... Families § 59.653 How do I test portable fuel containers? You must test the portable fuel container as.... Perform a slosh test by filling the portable fuel container to 40 percent of its capacity with the fuel...

Impact of Phlebotomine Sand Flies on U.S. Military Operations at Tallil Air Base, Iraq: 4. Detection and Identification of Leishmania Parasites in Sand Flies

DTIC Science & Technology

2009-05-01

FLIES 653 addition, DNA from three species of phlebotomine sand ßies Lutzomyia longipalpis (Lutz and Neiva), P. papatasi, and Phlebotomus argentipes...Med. 144: 660Ð664. Lawyer, P., andD. Young. 1991. Diapause and quiescence in Lutzomyia diabolica (Diptera:Psychodidae). Paras- sitologia. 33(Suppl...Canter, F. Keesing, and E. D. Rowton. 2004. Sand ßy ( Lutzomyia vexator) (Diptera:Psychodidae)populations inupstateNewYork: abundance, microhabitat, and

The Use of Dual Task Paradigms in Memory Research: A Methodological Assessment and an Evaluation of Effort as a Measure of Levels of Processing.

DTIC Science & Technology

1982-03-01

sustained monitoring tasks. Human Factors, 1979, 21, 647-653. Craik , F. I. M., & Lockhart , R. Levels of processing : A framework for memory research...original levels approach to human memory ( Craik & Lockhart , 1972) contended that verbal stimuli could be classified along a continuum ranging from...AND AN EVALUATION OF EFFORT AS A MEASURr OF LEVELS OF PROCESSING Arthur D. Fisk, William L. Derrick, and Walter Schneider REPORT HARL-ONR-8105 E. C

The Marine Geochemistry of Rhenium, Iridium and Platinum

DTIC Science & Technology

1991-09-01

6000C) with MoS 2. Ir enrichments in volcanic gases and sublimates have been measured at two hot-spot volcanoes ( Kilauea (Olmez et al. 1986) and...W. H. Zoller. (1986). "Iridium emissions from Kilauea volcano ." J. Geophvs. Res, 91(B1): 653-663. Orth, C. J., L. R. Quintana, J. S. Gilmore, J. E...Geological Society of London Special Publication. 158 Hildebrand, A.R., W.V. Boynton, and W.H. Zoller. (1984). " Kilauea volcano aerosols: evidence in

Effect of Common Neuropathologies on Progression of Late Life Cognitive Impairment

PubMed Central

Yu, Lei; Boyle, Patricia A.; Leurgans, Sue; Schneider, Julie A.; Kryscio, Richard J.; Wilson, Robert S.; Bennett, David A.

2015-01-01

Brain pathologies of Alzheimer’s, cerebrovascular and Lewy body diseases are common in old age, but the relationship of these pathologies with progression from normal cognitive function to the various stages of cognitive impairment is unknown. In this study, we fit latent Markov models from longitudinal cognitive data to empirically derive three latent stages corresponding to no impairment, mild impairment, and moderate impairment; then, we examined the associations of common neuropathologies with the rates of transition among these stages. Cognitive and neuropathological data were available from 653 autopsied participants in two ongoing cohort studies of aging who were cognitively healthy at baseline (mean baseline age 79.1 years) and had longitudinal cognitive data. On average, participants in these analyses developed mild impairment 5 years after enrollment, progressed to moderate impairment after an additional 3.4 years, and stayed impaired for 2.8 years until death. AD and chronic macroscopic infarcts were associated with a higher risk of progression to mild impairment and subsequently to moderate impairment. By contrast, Lewy bodies were associated only with progression from mild to moderate impairment. The 5-year probability of progression to mild or moderate impairment was 20% for persons without any of these three pathologies, 38% for AD only, 51% for AD and macroscopic infarcts, and 56% for AD, infarcts and Lewy bodies. Thus, the presence of AD pathology alone nearly doubles the risk of developing cognitive impairment in late life, and the presence of multiple pathologies further increases this risk over multiple years prior to death. PMID:25976345

STS-42 Commander Grabe uses DTO 653 MK1 Rowing Machine on OV-103's middeck

NASA Image and Video Library

1992-01-30

STS042-05-037 (30 Jan 1992) --- Astronaut Ronald J. Grabe, STS-42 commander, exercises using MK1 Rowing Machine on the middeck of Discovery, Orbiter Vehicle (OV) 103. Grabe is using the exercise device as part of Development Test Objective (DTO) 653, Evaluation of MK1 Rowing Machine. The forward lockers appear at Grabe's right and the sleep station behind him.

Influence of Angiotensin-Converting-Enzyme Gene Polymorphism on Echocardiographic Data of Patients with Ischemic Heart Failure.

PubMed

Duque, Gustavo Salgado; Silva, Dayse Aparecida da; Albuquerque, Felipe Neves de; Schneider, Roberta Siuffo; Gimenez, Alinne; Pozzan, Roberto; Rocha, Ricardo Mourilhe; Albuquerque, Denilson Campos de

2016-11-01

Association between angiotensin-converting-enzyme (ACE) gene polymorphisms and different clinical and echocardiographic outcomes has been described in patients with heart failure (HF) and coronary artery disease. Studying the genetic profile of the local population with both diseases is necessary to assess the occurrence of that association. To assess the frequency of ACE gene polymorphisms in patients with ischemic HF in a Rio de Janeiro population, as well as its association with echocardiographic findings. Genetic assessment of I/D ACE polymorphism in association with clinical, laboratory and echocardiographic analysis of 99 patients. The allele frequency was: 53 I alleles, and 145 D alleles. Genotype frequencies were: 49.5% DD; 47.48% DI; 3.02% II. Drug treatment was optimized: 98% on beta-blockers, and 84.8% on ACE inhibitors or angiotensin-receptor blocker. Echocardiographic findings: difference between left ventricular diastolic diameters (ΔLVDD) during follow-up: 2.98±8.94 (DD) vs. 0.68±8.12 (DI) vs. -11.0±7.00 (II), p=0.018; worsening during follow-up of the LV systolic diameter (LVSD): 65.3% DD vs. 19.0% DI vs. 0.0% II, p=0.01; of the LV diastolic diameter (LVDD): 65.3% DD vs. 46.8% DI vs. 0.0% II, p=0.03; and of the LV ejection fraction (LVEF): 67.3% DD vs. 40.4% DI vs. 33.3% II, p=0.024. Correlated with D allele: ΔLVEF, ΔLVSD, ΔLVDD. More DD genotype patients had worsening of the LVEF, LVSD and LVDD, followed by DI genotype patients, while II genotype patients had the best outcome. The same pattern was observed for ΔLVDD. Associação entre polimorfismos genéticos da enzima conversora da angiotensina (ECA) e diferentes evoluções clínicas e ecocardiográficas foi descrita em pacientes com insuficiência cardíaca (IC) e coronariopatia. O estudo do perfil genético da população local com as duas doenças torna-se necessário para verificar a ocorrência dessa associação. Avaliar a frequência dos polimorfismos genéticos da ECA em pacientes com IC de etiologia isquêmica de uma população do Rio de Janeiro e sua associação com achados ecocardiográficos. Avaliação genética do polimorfismo I/D da ECA associada a análise de dados clínicos, laboratoriais e ecocardiográficos de 99 pacientes. Foram encontrados 53 alelos I, 145 alelos D, quanto aos genótipos da ECA: 49,5% DD, 47,48% DI, 3,02% II. O tratamento medicamentoso foi otimizado com 98% usando betabloqueadores e 84,8%, IECA ou bloqueador do receptor de angiotensina. Achados ecocardiográficos: diferença entre os diâmetros diastólicos do ventrículo esquerdo (ΔVED): 2,98±8,94 (DD) vs. 0,68±8,12 (DI) vs. -11,0±7,00 (II), p=0,018; piora evolutiva do diâmetro sistólico do VE (VES): 65,3 % DD vs. 19,0 % DI vs. 0,0 % II, p=0,01; do diâmetro diastólico do VE (VED): 65,3 % DD vs. 46,8 % DI vs. 0,0 % II, p=0,03; e da fração de ejeção do VE (FEVE): 67,3 % DD vs. 40,4 % DI vs. 33,3 % II, p=0,024. Correlação com alelo D: ΔFEVE, ΔVES, ΔVED. Foram identificados mais pacientes com piora evolutiva da FEVE e dos diâmetros cavitários do VE no genótipo DD, seguido do DI, sendo o II o de melhor evolução. O mesmo padrão foi observado na ΔVED.

Anthropometrics and prognosis in diffuse large B-cell lymphoma: a multicentre study of 653 patients.

PubMed

Bendtsen, Mette Dahl; Munksgaard, Peter Svenssen; Severinsen, Marianne Tang; Bekric, Eric; Brieghel, Christian; Nielsen, Kristina Buchardi; Brown, Peter de Nully; Dybkaer, Karen; Johnsen, Hans Erik; Bøgsted, Martin; El-Galaly, Tarec Christoffer

2017-04-01

The impact of body mass index (BMI) and body surface area (BSA) on survival in diffuse large B-cell lymphoma (DLBCL) is controversial. Recent studies show superior outcomes for overweight and obese patients. A total of 653 R-CHOP(-like)-treated DLBCL patients were included in this retrospective cohort study. Patients, baseline clinicopathologic characteristics and treatment information were retrieved from the Danish Lymphoma Registry. Anthropometric measures were obtained from chemotherapy prescription charts. Underweight (BMI <18.5 kg/m 2 ) was associated with significantly worse progression-free survival (PFS) for male patients only in sex-stratified analyses (HR 3.92, 95% CI: 1.57-9.75, P = 0.003, for males; HR 1.65, 95% CI: 0.90-3.02, P = 0.107, for females). In multivariate analyses, underweight was associated with worse PFS for both sexes (HR 5.34, 95% CI: 2.07-13.79, P = 0.001, for males; HR 2.14, 95% CI: 1.12-4.08, P = 0.021, for females). Similar results were obtained in analyses of overall survival. In crude analyses, BSA <1.8 m 2 was associated with worse PFS for men and women (HR 1.65, 95% CI: 1.03-2.65, P = 0.039, for men; HR 1.62, 95% CI: 1.03-2.56, P = 0.037, for women). In multivariate analyses, however, these associations diminished. Our study demonstrates that underweight DLBCL patients have worse outcomes following R-CHOP as compared to normal as well as overweight patients. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Spatial and Temporal Point Tracking in Real Hyperspectral Images

DTIC Science & Technology

2006-08-26

Dr. Stanley Rotman 5e. WORK UNIT NUMBER 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) Ben-Gurion University of the Negev PO Box 653...results from a contract tasking Ben-Gurion University of the Negev as follows: The Grantee will investigate developing a full target detection module...point tracking in real hyper spectral imagesʺ  Benjamin Aminov, Ofir Nichtern, Stanley Rotman Page 1 of 102  BEN-GURION UNIVERSITY OF THE NEGEV

iss028e034854

NASA Image and Video Library

2011-08-31

ISS028-E-034854 (31 Aug. 2011) --- Russian cosmonaut Sergei Volkov, Expedition 28 flight engineer, checks the progress of a new growth experiment on the BIO-5 Rasteniya-2 (Plants-2) payload with its LADA-01 greenhouse in the Zvezda Service Module of the International Space Station.

Latest progress from the Daya Bay reactor neutrino experiment

NASA Astrophysics Data System (ADS)

Wang, Zhe; Daya Bay Collaboration

2016-05-01

Recently the Daya Bay reactor neutrino experiment has presented several new results about neutrino and reactor physics after acquiring a large data sample and after gaining a more sophisticated understanding of the experiment. In this talk I will introduce the latest progress made by the experiment including a three-flavor neutrino oscillation analysis using neutron capture on gadolinium, which gave sin2 2θ 13 = 0.084 ± 0.005 and |Δm2 ee| = (2.42 ±0.11) × 10-3 eV2, an independent θ 13 measurement using neutron capture on hydrogen, a search for a light sterile neutrino, and a measurement of the reactor antineutrino flux and spectrum.

View of the Russian BIO-5 Rasteniya-2/Lada-2 (Plants-2) plant growth experiment in the SM

NASA Image and Video Library

2003-03-12

ISS006-E-44999 (12 March 2003) --- A view of the Russian BIO-5 Rasteniya-2/Lada-2 (Plants-2) plant growth experiment located in the Zvezda Service Module on the International Space Station (ISS). A camera used for recording progress of the experiment is visible on the right.

Making E-Learning Invisible: Experience at King Khalid University, Saudi Arabia

ERIC Educational Resources Information Center

Alwalidi, Abdullah; Lefrere, Paul

2010-01-01

The authors describe progress at King Khalid University (KKU) in the Kingdom of Saudi Arabia in developing and implementing a user-centered road map for teaching and learning, with pervasive e-learning as a core element. They named the approach "Invisible" e-learning. As part of it, they are investigating ways to capture and share…

Two-photon exchange in elastic electron–proton scattering

DOE PAGES

Afanasev, A.; Blunden, P. G.; Hasell, D.; ...

2017-04-17

Here, we review recent theoretical and experimental progress on the role of two-photon exchange (TPE) in electron-proton scattering at low to moderate momentum transfers. We make a detailed comparison and analysis of the results of competing experiments on the ratio of e +p to e -p elastic scattering cross sections, and of the theoretical calculations describing them. A summary of the current experimental situation is provided, along with an outlook for future experiments.

Comparison of T stage, N stage, multifocality, and bilaterality in papillary thyroid carcinoma patients according to the presence of coexisting lymphocytic thyroiditis.

PubMed

Park, Jin Young; Kim, Dong Wook; Park, Ha Kyung; Ha, Tae Kwun; Jung, Soo Jin; Kim, Do Hun; Bae, Sang Kyun

2015-01-01

This study aimed to assess the relationship between coexisting lymphocytic thyroiditis and T-N stages of papillary thyroid carcinoma (PTC) by histopathological analysis. The study included 653 patients who underwent thyroid surgery for PTC at our hospital. Each case was classified as either Hashimoto's thyroiditis (HT), non-Hashimoto type of lymphocytic thyroiditis (NHLT), or normal according to the histopathology of thyroid parenchyma. Patient age, gender, surgical modality, location, T stage, N stage, multifocality and bilaterality were compared according to the histopathology. The prevalence of coexisting lymphocytic thyroiditis was 25.8% (169/653); HT (7.5%, 49/653) and NHLT (18.3%, 120/653). There were no significant differences in T stage, N stage, multifocality and bilaterality with regard to coexisting lymphocytic thyroiditis, regardless of whether HT and NHLT were considered collectively or discretely. Primary tumor size (p < 0.0001), location (p = 0.0011), N stage (p < 0.0001), multifocality (p < 0.0001) and bilaterality (p < 0.0001) differed significantly according to T stage, and gender (p = 0.0193), primary tumor size (p < 0.0001), T stage (p < 0.0001), multifocality (p < 0.0001) and bilaterality (p < 0.0001) differed significantly according to N stage. PTC patients with coexisting lymphocytic thyroiditis did not differ from those with normal parenchyma in terms of T stage, N stage, multifocality and bilaterality.

Computer Simulation of Great Lakes-St. Lawrence Seaway Icebreaker Requirements.

DTIC Science & Technology

1980-01-01

of Run No. 1 for Taconite Task Command ... ....... 6-41 6.22d Results of Run No. I for Oil Can Task Command ........ ... 6-42 6.22e Results of Run No...Port and Period for Run No. 2 ... .. ... ... 6-47 6.23c Results of Run No. 2 for Taconite Task Command ... ....... 6-48 6.23d Results of Run No. 2 for...6-53 6.24b Predicted Icebreaker Fleet by Home Port and Period for Run No. 3 6-54 6.24c Results of Run No. 3 for Taconite Task Command. ....... 6

Evaluation of pretreatment methods on mixed inoculum for both batch and continuous thermophilic biohydrogen production from cassava stillage.

PubMed

Luo, Gang; Xie, Li; Zou, Zhonghai; Wang, Wen; Zhou, Qi

2010-02-01

Anaerobic sludges, pretreated by chloroform, base, acid, heat and loading-shock, as well as untreated sludge were evaluated for their thermophilic fermentative hydrogen-producing characters from cassava stillage in both batch and continuous experiments. Results showed that the highest hydrogen production was obtained by untreated sludge and there were significant differences (p<0.05) in hydrogen yields (varied from 32.9 to 65.3mlH(2)/gVS) among the tested pretreatment methods in batch experiments. However, the differences in hydrogen yields disappeared in continuous experiments, which indicated the pretreatment methods had only short-term effects on the hydrogen production. Further study showed that alkalinity was a crucial parameter influencing the fermentation process. When the influent was adjusted to pH 6 by NaHCO(3) instead of NaOH, the hydrogen yield increased from about 40 to 52mlH(2)/gVS in all the experiments. Therefore, pretreatment of anaerobic sludge is unnecessary for practical thermophilic fermentative hydrogen production from cassava stillage.

Apollo lunar surface experiments package

NASA Technical Reports Server (NTRS)

1972-01-01

The ALSEP program status and monthly progress are reported. Environmental and quality control tests and test results are described. Details are given on the Apollo 17 Array E, and the lunar seismic profiling, ejecta and meteorites, mass spectrometer, surface gravimeter, and heat flow experiments. Monitoring of the four ALSEP systems on the moon is also described.

THE UBV(RI){sub C} COLORS OF THE SUN

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ramirez, I.; Michel, R.; Schuster, W. J.

2012-06-10

Photometric data in the UBV(RI){sub C} system have been acquired for 80 solar analog stars for which we have previously derived highly precise atmospheric parameters T{sub eff}, log g, and [Fe/H] using high-resolution, high signal-to-noise ratio spectra. UBV and (RI){sub C} data for 46 and 76 of these stars, respectively, are published for the first time. Combining our data with those from the literature, colors in the UBV(RI){sub C} system, with {approx_equal} 0.01 mag precision, are now available for 112 solar analogs. Multiple linear regression is used to derive the solar colors from these photometric data and the spectroscopically derivedmore » T{sub eff}, log g, and [Fe/H] values. To minimize the impact of systematic errors in the model-dependent atmospheric parameters, we use only the data for the 10 stars that most closely resemble our Sun, i.e., the solar twins, and derive the following solar colors: (B - V){sub Sun} = 0.653 {+-} 0.005, (U - B){sub Sun} = 0.166 {+-} 0.022, (V - R){sub Sun} = 0.352 {+-} 0.007, and (V - I){sub Sun} = 0.702 {+-} 0.010. These colors are consistent, within the 1{sigma} errors, with those derived using the entire sample of 112 solar analogs. We also derive the solar colors using the relation between spectral-line-depth ratios and observed stellar colors, i.e., with a completely model-independent approach, and without restricting the analysis to solar twins. We find (B - V){sub Sun} = 0.653 {+-} 0.003, (U - B){sub Sun} = 0.158 {+-} 0.009, (V - R){sub Sun} = 0.356 {+-} 0.003, and (V - I){sub Sun} = 0.701 {+-} 0.003, in excellent agreement with the model-dependent analysis.« less

MIT-CSR XIS Project

NASA Technical Reports Server (NTRS)

1998-01-01

This report outlines the proposers' progress toward MIT's contribution to the X-Ray Imaging Spectrometer (XIS) experiment on the Japanese ASTRO-E mission. The report discusses electrical system design, mechanical system design, and ground support equipment.

Automatic cataloguing and characterization of Earth science data using SE-trees

NASA Technical Reports Server (NTRS)

Rymon, Ron; Short, Nicholas M., Jr.

1994-01-01

In the future, NASA's Earth Observing System (EOS) platforms will produce enormous amounts of remote sensing image data that will be stored in the EOS Data Information System. For the past several years, the Intelligent Data Management group at Goddard's Information Science and Technology Office has been researching techniques for automatically cataloguing and characterizing image data (ADCC) from EOS into a distributed database. At the core of the approach, scientists will be able to retrieve data based upon the contents of the imagery. The ability to automatically classify imagery is key to the success of contents-based search. We report results from experiments applying a novel machine learning framework, based on Set-Enumeration (SE) trees, to the ADCC domain. We experiment with two images: one taken from the Blackhills region in South Dakota; and the other from the Washington DC area. In a classical machine learning experimentation approach, an image's pixels are randomly partitioned into training (i.e. including ground truth or survey data) and testing sets. The prediction model is built using the pixels in the training set, and its performance is estimated using the testing set. With the first Blackhills image, we perform various experiments achieving an accuracy level of 83.2 percent, compared to 72.7 percent using a Back Propagation Neural Network (BPNN) and 65.3 percent using a Gaussain Maximum Likelihood Classifier (GMLC). However, with the Washington DC image, we were only able to achieve 71.4 percent, compared with 67.7 percent reported for the BPNN model and 62.3 percent for the GMLC.

Colombia’s Experience Developing Its Capacity - To the Brink and Back

DTIC Science & Technology

2012-05-01

millones Movilidad 2.074.324 Inteligencia/ comunicaciones 539.587 Pie de fuerza (Incluye activación y sostenimiento 4 años) Total 37.849 2.095.216...integral y otros programas sectoriales 145.262 Subtotal 6.041.350 MANTENIMIENTO DE LAS CAPACIDADES ESTRATÉGICAS MÍNIMAS 1.437.653 Total 7.479.003 Asignado...Feb 1007 FLb 2008 Fab 2005’ Fc!b 20:Ul F1b :10] 1 FLb 2m2 I ro d,t; rf.IIODNAL I FU Eill:.S MR.ITAR.ES - ? f ... - s·JTu.A.cl6N._AcTuAL -oe-- LA

Requirements-Based Conformance Testing of ARINC 653 Real-Time Operating Systems

NASA Astrophysics Data System (ADS)

Maksimov, Andrey

2010-08-01

Requirements-based testing is emphasized in avionics certification documents because this strategy has been found to be the most effective at revealing errors. This paper describes the unified requirements-based approach to the creation of conformance test suites for mission-critical systems. The approach uses formal machine-readable specifications of requirements and finite state machine model for test sequences generation on-the-fly. The paper also presents the test system for automated test generation for ARINC 653 services built on this approach. Possible application of the presented approach to various areas of avionics embedded systems testing is discussed.

Automatic Implementation of Ttethernet-Based Time-Triggered Avionics Applications

NASA Astrophysics Data System (ADS)

Gorcitz, Raul Adrian; Carle, Thomas; Lesens, David; Monchaux, David; Potop-Butucaruy, Dumitru; Sorel, Yves

2015-09-01

The design of safety-critical embedded systems such as those used in avionics still involves largely manual phases. But in avionics the definition of standard interfaces embodied in standards such as ARINC 653 or TTEthernet should allow the definition of fully automatic code generation flows that reduce the costs while improving the quality of the generated code, much like compilers have done when replacing manual assembly coding. In this paper, we briefly present such a fully automatic implementation tool, called Lopht, for ARINC653-based time-triggered systems, and then explain how it is currently extended to include support for TTEthernet networks.

The Flow of Energy

NASA Astrophysics Data System (ADS)

Znidarsic, F.; Robertson, G. A.

In this paper, the flow of energy in materials is presented as mechanical waves with a distinct velocity or speed of transition. This speed of transition came about through the observations of cold fusion experiments, i.e., Low Energy Nuclear Reactions (LENR) and superconductor gravity experiments, both assumed speculative by mainstream science. In consideration of superconductor junctions, the LENR experiments have a similar speed of transition, which seems to imply that the reactions in the LENR experiment are discrete quantized reactions (energy - burst vs. continuous). Here an attempt is made to quantify this new condition as it applies to electrons; toward the progression of quantized energy flows (discrete energy burst) as a new source of clean energy and force mechanisms (i.e, propulsion).

Sensory experience ratings (SERs) for 1,659 French words: Relationships with other psycholinguistic variables and visual word recognition.

PubMed

Bonin, Patrick; Méot, Alain; Ferrand, Ludovic; Bugaïska, Aurélia

2015-09-01

We collected sensory experience ratings (SERs) for 1,659 French words in adults. Sensory experience for words is a recently introduced variable that corresponds to the degree to which words elicit sensory and perceptual experiences (Juhasz & Yap Behavior Research Methods, 45, 160-168, 2013; Juhasz, Yap, Dicke, Taylor, & Gullick Quarterly Journal of Experimental Psychology, 64, 1683-1691, 2011). The relationships of the sensory experience norms with other psycholinguistic variables (e.g., imageability and age of acquisition) were analyzed. We also investigated the degree to which SER predicted performance in visual word recognition tasks (lexical decision, word naming, and progressive demasking). The analyses indicated that SER reliably predicted response times in lexical decision, but not in word naming or progressive demasking. The findings are discussed in relation to the status of SER, the role of semantic code activation in visual word recognition, and the embodied view of cognition.

A point mutation in the ion conduction pore of AMPA receptor GRIA3 causes dramatically perturbed sleep patterns as well as intellectual disability

PubMed Central

Davies, Benjamin; Brown, Laurence A; Cais, Ondrej; Clayton, Amber J; Chang, Veronica T; Biggs, Daniel; Preece, Christopher; Hernandez-Pliego, Polinka; Krohn, Jon; Bhomra, Amarjit; Twigg, Stephen R F; Rimmer, Andrew; Kanapin, Alexander; Sen, Arjune; Zaiwalla, Zenobia; McVean, Gil; Foster, Russell; Donnelly, Peter; Taylor, Jenny C; Blair, Edward; Nutt, David; Aricescu, A Radu; Greger, Ingo H; Peirson, Stuart N; Flint, Jonathan

2017-01-01

Abstract The discovery of genetic variants influencing sleep patterns can shed light on the physiological processes underlying sleep. As part of a large clinical sequencing project, WGS500, we sequenced a family in which the two male children had severe developmental delay and a dramatically disturbed sleep-wake cycle, with very long wake and sleep durations, reaching up to 106-h awake and 48-h asleep. The most likely causal variant identified was a novel missense variant in the X-linked GRIA3 gene, which has been implicated in intellectual disability. GRIA3 encodes GluA3, a subunit of AMPA-type ionotropic glutamate receptors (AMPARs). The mutation (A653T) falls within the highly conserved transmembrane domain of the ion channel gate, immediately adjacent to the analogous residue in the Grid2 (glutamate receptor) gene, which is mutated in the mouse neurobehavioral mutant, Lurcher. In vitro, the GRIA3(A653T) mutation stabilizes the channel in a closed conformation, in contrast to Lurcher. We introduced the orthologous mutation into a mouse strain by CRISPR-Cas9 mutagenesis and found that hemizygous mutants displayed significant differences in the structure of their activity and sleep compared to wild-type littermates. Typically, mice are polyphasic, exhibiting multiple sleep bouts of sleep several minutes long within a 24-h period. The Gria3A653T mouse showed significantly fewer brief bouts of activity and sleep than the wild-types. Furthermore, Gria3A653T mice showed enhanced period lengthening under constant light compared to wild-type mice, suggesting an increased sensitivity to light. Our results suggest a role for GluA3 channel activity in the regulation of sleep behavior in both mice and humans. PMID:29016847

DOE Office of Scientific and Technical Information (OSTI.GOV)

Buchanan, Charles D.; Cline, David B.; Byers, N.

Progress in the various components of the UCLA High-Energy Physics Research program is summarized, including some representative figures and lists of resulting presentations and published papers. Principal efforts were directed at the following: (I) UCLA hadronization model, PEP4/9 e{sup +}e{sup {minus}} analysis, {bar P} decay; (II) ICARUS and astroparticle physics (physics goals, technical progress on electronics, data acquisition, and detector performance, long baseline neutrino beam from CERN to the Gran Sasso and ICARUS, future ICARUS program, and WIMP experiment with xenon), B physics with hadron beams and colliders, high-energy collider physics, and the {phi} factory project; (III) theoretical high-energy physics;more » (IV) H dibaryon search, search for K{sub L}{sup 0} {yields} {pi}{sup 0}{gamma}{gamma} and {pi}{sup 0}{nu}{bar {nu}}, and detector design and construction for the FNAL-KTeV project; (V) UCLA participation in the experiment CDF at Fermilab; and (VI) VLPC/scintillating fiber R D.« less

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

Progress in the various components of the UCLA High-Energy Physics Research program is summarized, including some representative figures and lists of resulting presentations and published papers. Principal efforts were directed at the following: (I) UCLA hadronization model, PEP4/9 e{sup +}e{sup {minus}} analysis, {bar P} decay; (II) ICARUS and astroparticle physics (physics goals, technical progress on electronics, data acquisition, and detector performance, long baseline neutrino beam from CERN to the Gran Sasso and ICARUS, future ICARUS program, and WIMP experiment with xenon), B physics with hadron beams and colliders, high-energy collider physics, and the {phi} factory project; (III) theoretical high-energy physics;more » (IV) H dibaryon search, search for K{sub L}{sup 0} {yields} {pi}{sup 0}{gamma}{gamma} and {pi}{sup 0}{nu}{bar {nu}}, and detector design and construction for the FNAL-KTeV project; (V) UCLA participation in the experiment CDF at Fermilab; and (VI) VLPC/scintillating fiber R & D.« less

Fulda AAF, Germany. Revised Uniform Summary of Surface Weather Observations (RUSSWO). Parts A-F

DTIC Science & Technology

1972-02-08

62,21~ 62 62.2 62.2 62.6 62.6j 62,6 62 6 0.62.s2 653,.> 100 101 17,11 63 tD 03~ 15 63. 0j, 64#J t,4o^, 64.O04,C 4 ’.cl 64,9>_ ___ 51.4 56 61.7 64,9...STATION hAMi YEARSo _Te_ WET BULB TEMPERA) URE DEPRESSION (F) I 7OTAL 1 TOTAL (F) ~ ~ ~ 1 11 ___ _:_~1~ 24~2 2?2 L.9 B , l B . BbD & Po ___--- I __ __ , I...34,, lOt, Th 1$/ 37 s 44 . 4 14 - 22/_ 31 -I 11 6 / 1 2_ __ JAL 2 7Z.1. 7 .~ TD -e 214267~ 3E75 2# Is- 91 9 ___ I;~~91 90__ 1 .-..- SElm t CX) 4x ’ o 1 ~ Obs

Development of an Assessment Model for Sustainable Supply Chain Management in Batik Industry

NASA Astrophysics Data System (ADS)

Mubiena, G. F.; Ma’ruf, A.

2018-03-01

This research proposes a dynamic assessment model for sustainable supply chain management in batik industry. The proposed model identifies the dynamic relationship between economic aspect, environment aspect and social aspect. The economic aspect refers to the supply chain operation reference model. The environment aspect uses carbon emissions and liquid waste as the attribute assessment, while the social aspect focus on employee’s welfare. Lean manufacturing concept was implemented as an alternative approach to sustainability. The simulation result shows that the average of sustainability score for 5 years increased from 65,3% to 70%. Future experiments will be conducted on design improvements to reach the company target on sustainability score.

Childhood adversity, mental disorder comorbidity, and suicidal behavior in schizotypal personality disorder.

PubMed

Lentz, Vanessa; Robinson, Jennifer; Bolton, James M

2010-11-01

Schizotypal personality disorder (SPD) is a serious and relatively common psychiatric disorder, yet remains understudied among the personality disorders. The current study examines the psychiatric correlates of SPD in a representative epidemiologic sample, utilizing data from the National Epidemiological Survey on Alcohol and Related Conditions (N = 34,653). Multiple logistic regression compared people with SPD to the general population across a broad range of childhood adversities, comorbid psychiatric disorders, and suicidal behavior. SPD was strongly associated with many adverse childhood experiences. After adjusting for confounding factors, SPD was independently associated with major depression and several anxiety disorders, including post-traumatic stress disorder. Interestingly, SPD was more strongly associated with borderline and narcissistic personality disorders than cluster A personality disorders. Individuals with SPD were also more likely to attempt suicide. As a whole, these results suggest that individuals with SPD experience significant morbidity and may be at increased risk of mortality.

Molecular analysis of two genes between let-653 and let-56 in the unc-22(IV) region of Caenorhabditis elegans.

PubMed

Marra, M A; Prasad, S S; Baillie, D L

1993-01-01

A previous study of genomic organization described the identification of nine potential coding regions in 150 kb of genomic DNA from the unc-22(IV) region of Caenorhabditis elegans. In this study, we focus on the genomic organization of a small interval of 0.1 map unit bordered on the right by unc-22 and on the left by the left-hand breakpoints of the deficiencies sDf9, sDf19 and sDf65. This small interval at present contains a single mutagenically defined locus, the essential gene let-56. The cosmid C11F2 has previously been used to rescue let-56. Therefore, at least some of C11F2 must reside in the interval. In this paper, we report the characterization of two coding elements that reside on C11F2. Analysis of nucleotide sequence data obtained from cDNAs and cosmid subclones revealed that one of the coding elements closely resembles aromatic amino acid decarboxylases from several species. The other of these coding elements was found to closely resemble a human growth factor activatable Na+/H+ antiporter. Paris of oligonucleotide primers, predicted from both coding elements, have been used in PCR experiments to position these coding elements between the left breakpoint of sDf19 and the left breakpoint of sDf65, between the essential genes let-653 and let-56.

Digital chalk-talk videos improve knowledge and satisfaction in renal physiology.

PubMed

Roberts, John K; Chudgar, Saumil M; Engle, Deborah; McClain, Elizabeth K; Jakoi, Emma; Berkoben, Michael; Lehrich, Ruediger W

2018-03-01

The authors began a curriculum reform project to improve the experience in a Renal Physiology course for first-year medical students. Taking into account both the variety of learning preferences among students and the benefits of student autonomy, the authors hypothesized that adding digital chalk-talk videos to lecture notes and live lectures would improve student knowledge, course satisfaction, and engagement. The authors measured performance on the renal physiology exam before (the traditional curriculum) and for 2 yr after implementation of the new curriculum. During the traditional and subsequent years, students took a Q-sort survey before and after the Renal Physiology course. Satisfaction was assessed based on ranked statements in the Q sort, as well as through qualitative analysis of student commentary. Compared with the traditional curriculum, mean scores on the renal physiology final exam were higher after implementation of the new curriculum: 65.3 vs. 74.4 ( P < 0.001) with year 1 and 65.3 vs. 79.4 ( P < 0.001) in the second year. After the new curriculum, students were more likely to agree with the statement, "I wish other courses were taught like this one." Qualitative analysis revealed how the video-based curriculum improved student engagement and satisfaction. Adding digital chalk-talk videos to a traditional Renal Physiology course that included active learning led to improved exam performance and high levels of student satisfaction. Other preclinical courses in medical school may benefit from such an intervention.

PACE Continuous Innovation Indicators-a novel tool to measure progress in cancer treatments.

PubMed

Paddock, Silvia; Brum, Lauren; Sorrow, Kathleen; Thomas, Samuel; Spence, Susan; Maulbecker-Armstrong, Catharina; Goodman, Clifford; Peake, Michael; McVie, Gordon; Geipel, Gary; Li, Rose

2015-01-01

Concerns about rising health care costs and the often incremental nature of improvements in health outcomes continue to fuel intense debates about 'progress' and 'value' in cancer research. In times of tightening fiscal constraints, it is increasingly important for patients and their representatives to define what constitutes 'value' to them. It is clear that diverse stakeholders have different priorities. Harmonisation of values may be neither possible nor desirable. Stakeholders lack tools to visualise or otherwise express these differences and to track progress in cancer treatments based on variable sets of values. The Patient Access to Cancer care Excellence (PACE) Continuous Innovation Indicators are novel, scientifically rigorous progress trackers that employ a three-step process to quantify progress in cancer treatments: 1) mine the literature to determine the strength of the evidence supporting each treatment; 2) allow users to weight the analysis according to their priorities and values; and 3) calculate Evidence Scores (E-Scores), a novel measure to track progress, based on the strength of the evidence weighted by the assigned value. We herein introduce a novel, flexible value model, show how the values from the model can be used to weight the evidence from the scientific literature to obtain E-Scores, and illustrate how assigning different values to new treatments influences the E-Scores. The Indicators allow users to learn how differing values lead to differing assessments of progress in cancer research and to check whether current incentives for innovation are aligned with their value model. By comparing E-Scores generated by this tool, users are able to visualise the relative pace of innovation across areas of cancer research and how stepwise innovation can contribute to substantial progress against cancer over time. Learning from experience and mapping current unmet needs will help to support a broad audience of stakeholders in their efforts to accelerate and maximise progress against cancer.

Theoretical analysis of the time-resolved binary (e, 2e) binding energy spectra on three-body photodissociation of acetone at 195 nm

NASA Astrophysics Data System (ADS)

Yamazaki, M.; Nakayama, S.; Zhu, C. Y.; Takahashi, M.

2017-11-01

We report on theoretical progress in time-resolved (e, 2e) electron momentum spectroscopy of photodissociation dynamics of the deuterated acetone molecule at 195 nm. We have examined the predicted minimum energy reaction path to investigate whether associated (e, 2e) calculations meet the experimental results. A noticeable difference between the experiment and calculations has been found at around binding energy of 10 eV, suggesting that the observed difference may originate, at least partly, in ever-unconsidered non-minimum energy paths.

Hypernuclear Spectroscopy at JLab Hall C

NASA Astrophysics Data System (ADS)

Hashimoto, O.; Chiba, A.; Doi, D.; Fujii, Y.; Gogami, T.; Kanda, H.; Kaneta, M.; Kawama, D.; Maeda, K.; Maruta, T.; Matsumura, A.; Nagao, S.; Nakamura, S. N.; Shichijo, A.; Tamura, H.; Taniya, N.; Yamamoto, T.; Yokota, K.; Kato, S.; Sato, Y.; Takahashi, T.; Noumi, H.; Motoba, T.; Hiyama, E.; Albayrak, I.; Ates, O.; Chen, C.; Christy, M.; Keppel, C.; Kohl, M.; Li, Y.; Liyanage, A.; Tang, L.; Walton, T.; Ye, Z.; Yuan, L.; Zhu, L.; Baturin, P.; Boeglin, W.; Dhamija, S.; Markowitz, P.; Raue, B.; Reinhold, J.; Hungerford, Ed. V.; Ent, R.; Fenker, H.; Gaskell, D.; Horn, T.; Jones, M.; Smith, G.; Vulcan, W.; Wood, S. A.; Johnston, C.; Simicevic, N.; Wells, S.; Samanta, C.; Hu, B.; Shen, J.; Wang, W.; Zhang, X.; Zhang, Y.; Feng, J.; Fu, Y.; Zhou, J.; Zhou, S.; Jiang, Y.; Lu, H.; Yan, X.; Ye, Y.; Gan, L.; Ahmidouch, A.; Danagoulian, S.; Gasparian, A.; Elaasar, M.; Wesselmann, F. R.; Asaturyan, A.; Margaryan, A.; Mkrtchyan, A.; Mkrtchyan, H.; Tadevosyan, V.; Androic, D.; Furic, M.; Petkovic, T.; Seva, T.; Niculescu, G.; Niculescu, I.; Rodriguez, V. M.; Cisbani, E.; Cusanno, F.; Garibaldi, F.; Uuciuoli, G. M.; De Leo, R.; Maronne, S.; Achenback, P.; Pochodzala, J.

2010-04-01

Since the 1st generation experiment, E89-009, which was successfully carried out as a pilot experiment of (e,e'K+) hypernuclear spectroscopy at JLab Hall C in 2000, precision hypernuclear spectroscopy by the (e,e'K+) reactions made considerable progress. It has evolved to the 2nd generation experiment, E01-011, in which a newly constructed high resolution kaon spectrometer (HKS) was installed and the "Tilt method" was adopted in order to suppress large electromagnetic background and to run with high luminosity. Preliminary high-resolution spectra of 7ΛHe and 28ΛAl together with that of 12ΛB that achieved resolution better than 500 keV(FWHM) were obtained. The third generation experiment, E05-115, has completed data taking with an experimental setup combining a new splitter magnet, high resolution electron spectrometer (HES) and the HKS used in the 2nd generation experiment. The data were accumulated with targets of 7Li, 9Be, 10B, 12C and 52Cr as well as with those of CH 2 and H 2O for calibration. The analysis is under way with particular emphasis of determining precision absolute hypernuclear masses. In this article, hypernuclear spectroscopy program in the wide mass range at JLab Hall C that has undergone three generation is described.

Magnetoresistance Studies in the Low-Dimensional Organic Metal α-(ET){2}TlHg(SeCN){4} under Pressure: Experiments and Simulation by Tight Binding Band Structure Calculations

NASA Astrophysics Data System (ADS)

Auban-Senzier, P.; Audouard, A.; Laukhin, V. N.; Rousseau, R.; Canadell, E.; Brossard, L.; Jérome, D.; Kushch, N. D.

1995-10-01

Magnetotransport measurements have been carried out in layered organic metal α-(ET){2}TlHg(SeCN){4} at temperatures down to 0.4 K and under hydrostatic pressure. Only one... Des mesures de magnétorésistance ont été effectuées dans le conducteur organique bidimensionnel α-(ET){2}TlHg(SeCN){4} jusqu'à la température de 0.4 K et sous pression hydrostatique. Une seule série d'oscillations Shubnikov-de Haas est observée dans la gamme de pression comprise entre 3.5 et 11 kbar. La masse cyclotron décroit lentement lorsque la pression augmente et la fréquence des oscillations augmente rapidement depuis la valeur de (653± 3)T à pression ambiante jusqu'à (790± 3)T à 11 kbar. Une modélisation basée sur la méthode des liaisons fortes suggère que la dépendance en pression de l'aire de l'orbite fermée de la surface de Fermi est due au glissement, induit par la pression, des molécules des chaines ne contenant qu'un type de donneurs. Au contraire de son composé frère α-(ET){2}NH{4}Hg(SCN){4}, il présente des oscillations lentes, de fréquence (47± 3)T, à pression ambiante. Elles ne sont pas observées entre 3.5 et 11 kbar et pourraient être en relation avec un emboîtement des orbites ouvertes à pression ambiante qui pourraient détruire la supraconductivité dans le composé à base de sélénium.

Experimental and Theoretical Progress on the GEM Theory

NASA Astrophysics Data System (ADS)

Brandenburg, J. E.

This paper reports experimental and theoretical progress on the GEM unification theory. In theoretical progress, the derivation of the GEM theory using it in a fully covariant form is achieved based on the principle of self-cancellation of the ZPF EM stress-momentum tensor. This derivation reveals that the final Gravity-EM system obeys a Helmholtz-like equation resembling that governing sound propagation. Finally an improved derivation of the formula for the Newton Gravitation constant is shown, qresulting in the formula G = e2/(4πɛ0 me mp) α exp (-2 (α-.86/σ2…) = 6.673443 x10-11 N-m2 kg-2 that agrees with experimental values to 3 parts per 100,000. Experiments have found parity violating weight reductions in gyroscopes driven by rotating EM fields. These experiments appear to confirm gravity modification using electromagnetism predicted by the GEM theory through the Vacuum Bernoulli Equation.

Indian adolescents' perceptions of the home food environment.

PubMed

Rathi, Neha; Riddell, Lynn; Worsley, Anthony

2018-01-22

The home food environment has the potential to influence the eating behaviour of adolescents. This investigation aimed to understand Indian adolescents' perspectives of their home food environments. Adolescents aged 14-16 years (n = 1026, 65.3% girls) attending private secondary schools in Kolkata completed a paper-based questionnaire during school time which included questions about family food rules, availability and accessibility of foods at home, and domestic cooking responsibility. Boys' and girls' opinions and experiences were compared through cross-tabulation analyses. Almost all the adolescents reported that fruits (91.6%) and vegetables (95.7%) were always available in their homes. Approximately two-fifths reported that sugar-sweetened beverages (36.2%) and salty snack foods (38.0%) were readily available. In 56.1% households, adolescents were expected to follow certain food rules during mealtimes (e.g. not talking with my mouth full). The majority of the respondents (80.4%) identified mothers as the primary meal providers, only a minority reported that fathers (5.1%) were responsible for preparation of family meals. This understanding of the family-environmental determinants of adolescent dietary habits provides useful directions for nutrition promotion interventions. Health and educational professionals associated with adolescents could communicate about the development of healthy home food environments to provide positive health benefits for adolescents and their families.

Identification of Ciprofloxacin Resistance by SimpleProbe (trademark), High Resolution Melt and Pyrosequencing (trademark) Nucleic Acid Analysis in Biothreat Agents: Bacillus anthracis, Yersinia pestis and Francisella tularensis

DTIC Science & Technology

2010-01-01

A266/ C gyrB: F1163-BIO GTG TTG CAG CGA AAA AAG C R1469 ATA TCA AAA TCT CCG CCA ATG T S1309 50-ATC CAC CGG CAG AGT-30 G1309/ A S1431 AAT AAT TGT ACG...CAC TTC AT A1423/G parC: F177 AGC GTT CCG TAA GTC GGC TAA A R342-BIO CGG ATC CCC GTC AAC ACT S227 ACC CGC ACG GTG ATT C242/ Te Y. pestis KIM5 gryA...ACA TGG CAT TTT GAA AC R694-BIO GGA GTG TTT CAG CTT CTA GTT TAT GGT S625 AAG CTT ACA TGG CAT TTT GAA AC del: bp 653e657 (TTAAA) a F e Forward (Upstream

PACE Continuous Innovation Indicators—a novel tool to measure progress in cancer treatments

PubMed Central

Paddock, Silvia; Brum, Lauren; Sorrow, Kathleen; Thomas, Samuel; Spence, Susan; Maulbecker-Armstrong, Catharina; Goodman, Clifford; Peake, Michael; McVie, Gordon; Geipel, Gary; Li, Rose

2015-01-01

Concerns about rising health care costs and the often incremental nature of improvements in health outcomes continue to fuel intense debates about ‘progress’ and ‘value’ in cancer research. In times of tightening fiscal constraints, it is increasingly important for patients and their representatives to define what constitutes ’value’ to them. It is clear that diverse stakeholders have different priorities. Harmonisation of values may be neither possible nor desirable. Stakeholders lack tools to visualise or otherwise express these differences and to track progress in cancer treatments based on variable sets of values. The Patient Access to Cancer care Excellence (PACE) Continuous Innovation Indicators are novel, scientifically rigorous progress trackers that employ a three-step process to quantify progress in cancer treatments: 1) mine the literature to determine the strength of the evidence supporting each treatment; 2) allow users to weight the analysis according to their priorities and values; and 3) calculate Evidence Scores (E-Scores), a novel measure to track progress, based on the strength of the evidence weighted by the assigned value. We herein introduce a novel, flexible value model, show how the values from the model can be used to weight the evidence from the scientific literature to obtain E-Scores, and illustrate how assigning different values to new treatments influences the E-Scores. The Indicators allow users to learn how differing values lead to differing assessments of progress in cancer research and to check whether current incentives for innovation are aligned with their value model. By comparing E-Scores generated by this tool, users are able to visualise the relative pace of innovation across areas of cancer research and how stepwise innovation can contribute to substantial progress against cancer over time. Learning from experience and mapping current unmet needs will help to support a broad audience of stakeholders in their efforts to accelerate and maximise progress against cancer. PMID:25624879

Trainability of Muscular Activity Level during Maximal Voluntary Co-Contraction: Comparison between Bodybuilders and Nonathletes

PubMed Central

Maeo, Sumiaki; Takahashi, Takumi; Takai, Yohei; Kanehisa, Hiroaki

2013-01-01

Antagonistic muscle pairs cannot be fully activated simultaneously, even with maximal effort, under conditions of voluntary co-contraction, and their muscular activity levels are always below those during agonist contraction with maximal voluntary effort (MVE). Whether the muscular activity level during the task has trainability remains unclear. The present study examined this issue by comparing the muscular activity level during maximal voluntary co-contraction for highly experienced bodybuilders, who frequently perform voluntary co-contraction in their training programs, with that for untrained individuals (nonathletes). The electromyograms (EMGs) of biceps brachii and triceps brachii muscles during maximal voluntary co-contraction of elbow flexors and extensors were recorded in 11 male bodybuilders and 10 nonathletes, and normalized to the values obtained during the MVE of agonist contraction for each of the corresponding muscles (% EMGMVE). The involuntary coactivation level in antagonist muscle during the MVE of agonist contraction was also calculated. In both muscles, % EMGMVE values during the co-contraction task for bodybuilders were significantly higher (P<0.01) than those for nonathletes (biceps brachii: 66±14% in bodybuilders vs. 46±13% in nonathletes, triceps brachii: 74±16% vs. 57±9%). There was a significant positive correlation between a length of bodybuilding experience and muscular activity level during the co-contraction task (r = 0.653, P = 0.03). Involuntary antagonist coactivation level during MVE of agonist contraction was not different between the two groups. The current result indicates that long-term participation in voluntary co-contraction training progressively enhances muscular activity during maximal voluntary co-contraction. PMID:24260233

Progress towards ultracold gases in arbitrary 2D potentials

NASA Astrophysics Data System (ADS)

Corcovilos, Theodore

2016-05-01

We describe our progress in building an apparatus for investigating degenerate quantum gases of potassium in arbitrary two-dimensional optical potentials. The optical potentials are created by holographic projection of an image created using a MEMS mirror array. Systems we would like to study with this experiment are quantum simulations of bosons and fermions at crystal heterojunctions and systems with well defined boundaries, including topological edge states. Funding provided by the Charles E Kaufman Foundation, a part of the Pittsburgh Foundation.

A point mutation in the ion conduction pore of AMPA receptor GRIA3 causes dramatically perturbed sleep patterns as well as intellectual disability.

PubMed

Davies, Benjamin; Brown, Laurence A; Cais, Ondrej; Watson, Jake; Clayton, Amber J; Chang, Veronica T; Biggs, Daniel; Preece, Christopher; Hernandez-Pliego, Polinka; Krohn, Jon; Bhomra, Amarjit; Twigg, Stephen R F; Rimmer, Andrew; Kanapin, Alexander; Sen, Arjune; Zaiwalla, Zenobia; McVean, Gil; Foster, Russell; Donnelly, Peter; Taylor, Jenny C; Blair, Edward; Nutt, David; Aricescu, A Radu; Greger, Ingo H; Peirson, Stuart N; Flint, Jonathan; Martin, Hilary C

2017-10-15

The discovery of genetic variants influencing sleep patterns can shed light on the physiological processes underlying sleep. As part of a large clinical sequencing project, WGS500, we sequenced a family in which the two male children had severe developmental delay and a dramatically disturbed sleep-wake cycle, with very long wake and sleep durations, reaching up to 106-h awake and 48-h asleep. The most likely causal variant identified was a novel missense variant in the X-linked GRIA3 gene, which has been implicated in intellectual disability. GRIA3 encodes GluA3, a subunit of AMPA-type ionotropic glutamate receptors (AMPARs). The mutation (A653T) falls within the highly conserved transmembrane domain of the ion channel gate, immediately adjacent to the analogous residue in the Grid2 (glutamate receptor) gene, which is mutated in the mouse neurobehavioral mutant, Lurcher. In vitro, the GRIA3(A653T) mutation stabilizes the channel in a closed conformation, in contrast to Lurcher. We introduced the orthologous mutation into a mouse strain by CRISPR-Cas9 mutagenesis and found that hemizygous mutants displayed significant differences in the structure of their activity and sleep compared to wild-type littermates. Typically, mice are polyphasic, exhibiting multiple sleep bouts of sleep several minutes long within a 24-h period. The Gria3A653T mouse showed significantly fewer brief bouts of activity and sleep than the wild-types. Furthermore, Gria3A653T mice showed enhanced period lengthening under constant light compared to wild-type mice, suggesting an increased sensitivity to light. Our results suggest a role for GluA3 channel activity in the regulation of sleep behavior in both mice and humans. © The Author 2017. Published by Oxford University Press.

Association between low lean mass and low bone mineral density in 653 women with hip fracture: does the definition of low lean mass matter?

PubMed

Di Monaco, Marco; Castiglioni, Carlotta; Di Monaco, Roberto; Tappero, Rosa

2017-12-01

Loss of both muscle and bone mass results in fragility fractures with increased risk of disability, poor quality of life, and death. Our aim was to assess the association between low appendicular lean mass (aLM) defined according to different criteria and low bone mineral density (BMD) in hip-fracture women. Six hundred fifty-three women admitted to our rehabilitation hospital underwent dual energy X-ray absorptiometry 19.1 ± 4.1 (mean ± SD) days after hip-fracture occurrence. Low aLM was identified according to either Baumgartner's definition (aLM/height 2 less than two standard deviations below the mean of the young reference group) or FNIH criteria: aLM <15.02 kg, or aLM adjusted for body mass index (BMI) <0.512. Low BMD was diagnosed with a T-score <-2.5 at the unfractured femoral neck. Using Baumgartner's definition, the association between low aLM/height 2 and low BMD was significant: χ 2 (1, n = 653) = 8.52 (p = 0.004), but it was erased by adjustments for age and fat mass. Using the FNIH definition the association between low aLM and low BMD was significant: χ 2 (1, n = 653) = 42.5 (p < 0.001), and it was confirmed after adjustment for age and fat mass (p < 0.001). With the FNIH definition based on aLM/BMI ratio the association between low aLM/BMI ratio and low BMD was nonsignificant: χ 2 (1, n = 653) = 0.003 (p = 0.957). The association between low aLM and low BMD in women with hip fracture dramatically depends on the adopted definition of low aLM. FNIH threshold for aLM (<15.02 kg) emerges as a useful tool to capture women with damage of the muscle-bone unit.

Circular RNA hsa_circ_0008039 promotes breast cancer cell proliferation and migration by regulating miR-432-5p/E2F3 axis.

PubMed

Liu, Yanhua; Lu, Cuntao; Zhou, Yizhou; Zhang, Zhihong; Sun, Li

2018-07-20

As the development of sequencing technology, more and more circular RNAs (circRNAs) are identified in human cancer tissues. Increasing evidences imply circRNAs are important regulators in tumor progression. Nevertheless, how circRNAs participate in breast cancer development and progression is not well understood. In the present study, we identified a novel circRNA hsa_circ_0008039 with upregulated expression level in breast cancer tissues. By functional experiments, we found that hsa_circ_0008039 depletion significantly suppressed the proliferation, arrested cell-cycle progression and reduced migration in breast cancer. Mechanistic investigations suggested that hsa_circ_0008039 served as a competing endogenous RNA (ceRNA) of miR-432-5p. Subsequently, E2F3 was identified as the functional target of miR-432-5p and overexpression of hsa_circ_0008039 elevated E2F3 expression in breast cancer. On the whole, our study indicated that hsa_circ_0008039 exerted oncogenic roles in breast cancer and suggested the hsa_circ_0008039/miR-432-5p/E2F3 axis might be a potential therapeutic target. Copyright © 2018 Elsevier Inc. All rights reserved.

Consequences of adding gum Arabic as a cryoprotectant on motility and viability of frozen stallion semen.

PubMed

Ali, Mohamed; Musa, Musa M; Alfadul, Sulaiman; Al-Sobayel, K

2017-12-01

A trial was conducted to check effect of adding gum Arabic (GA) instead of egg yolk (EY) as a cryoprotectant for stallion sperm. Two experiments were designed; experiment I tested adding 3 levels of nonheated GA (i.e., 3, 6 and 9 g/100 mL diluents) in HF-20 extender. However, in experiment II the same levels were tested except that GA was heated at 80 °C for 60 min. HF-20 containing 10% of EY was used as control. In experiment I, sperm frozen in HF-20 containing nonheated GA exhibited lower percentages of motile sperm, progressively motile sperm and sperm with intact plasma membranes, vitality rate, and acrosome integrity after cooling or after deep freezing. Frozen semen in HF-20 containing 3-6% of preheated GA in experiment II maintained sperm motility at 46-50% and elevated progressive motility at 27%. The semen diluted in preheated GA (6%) and frozen exhibited a fertility rate of 40% (2/5). A similar fertility rate (40%) was found in the control semen (i.e. 10%) compared to those that were inseminated with frozen semen in preheated 3% GA (20%, 1/5). These results suggest that preheated GA could be used as an alternative cryoprotectant for cryopreserving stallion sperm. Copyright © 2017 Elsevier Inc. All rights reserved.

Sexual orientation disparities in substance misuse: the role of childhood abuse and intimate partner violence among patients in care at an urban community health center.

PubMed

Reisner, Sari L; Falb, Kathryn L; Wagenen, Aimee Van; Grasso, Chris; Bradford, Judith

2013-02-01

This study examined disparities in lifetime substance misuse by sexual orientation among 2,653 patients engaged in care at an urban community health center in Boston, MA, as well as the potential mediating roles of childhood abuse

Arsenic mineral dissolution and possible mobilization in mineral-microbe-groundwater environment.

PubMed

Islam, A B M R; Maity, Jyoti Prakash; Bundschuh, Jochen; Chen, Chien-Yen; Bhowmik, Bejon Kumar; Tazaki, Kazue

2013-11-15

Arsenic (As) is widely distributed in the nature as ores or minerals. It has been attracted much attention for the global public health issue, especially for groundwater As contamination. The aim of this study was to elucidate the characteristics of microbes in groundwater where As-minerals were dissolved. An ex situ experiment was conducted with 7 standard As-minerals in bacteria-free groundwater and stored in experimental vessels for 1 year without supplementary nutrients. The pH (6.7-8.4) and EhS.H.E. (24-548 mV) changed between initial (0 day) and final stages (365 days) of experiment. The dissolution of As was detected higher from arsenolite (4240 ± 8.69 mg/L) and native arsenic (4538 ± 9.02 mg/L), whereas moderately dissolved from orpiment (653 ± 3.56 mg/L) and realgar (319 ± 2.56 mg/L) in compare to arsenopyrite (85 ± 1.25mg/L) and tennantite (3 ± 0.06 mg/L). Optical microscopic, scanning electron microscopic observations and flurometric enumeration revealed the abundance of As-resistant bacillus, coccus and filamentous types of microorganisms on the surface of most of As-mineral. 4'-6-Diamidino-2-phenylindole (DAPI)-stained epifluorescence micrograph confirmed the presence of DNA and carboxyfluorescein diacetate (CFDA) staining method revealed the enzymatically active bacteria on the surface of As-minerals such as in realgar (As4S4). Therefore, the microbes enable to survive and mobilize the As in groundwater by dissolution/bioweathering of As-minerals. Copyright © 2012. Published by Elsevier B.V.

Creating or Capturing Reality? Historical Photographs of the Progressive Era

ERIC Educational Resources Information Center

Callahan, Cory

2015-01-01

As pictorial-based social media (e.g., Instagram, Pinterest, Snapchat, Tumblr) continue to encourage and sustain contemporary culture, the future success of America's democratic experiment may increasingly depend on its citizens' ability to critique visual information and take informed action. Promoting critical, historical analysis of…

The Muon g - 2 experiment at Fermilab

NASA Astrophysics Data System (ADS)

Mott, James; Muon g - 2 experiment

2017-06-01

The Muon g - 2 experiment at Fermilab will measure the anomalous magnetic moment of the muon to a precision of 140 ppb, reducing the experimental uncertainty by a factor of 4 compared to the previous measurement at BNL (E821). The measurement technique adopts the storage ring concept used for E821, with magic-momentum muons stored in a highly uniform 1.45 T magnetic dipole field. The spin precession frequency is extracted from an analysis of the modulation of the rate of higher-energy positrons from muon decays, detected by 24 calorimeters and 3 straw tracking detectors. Compared to the E821 experiment, muon beam preparation, storage ring internal hardware, field measuring equipment, and detector and electronics systems are all new or significantly upgraded. Herein, I report on the status of the experiment as of Sept. 2016, presenting the magnetic field uniformity results after the completion of the first round of shimming and outlining the construction progress of the main detector systems.

The Muon g $-$ 2 experiment at Fermilab

DOE PAGES

Mott, James

2017-06-21

Here, the Muon g-2 experiment at Fermilab will measure the anomalous magnetic moment of the muon to a precision of 140 ppb, reducing the experimental uncertainty by a factor of 4 compared to the previous measurement at BNL (E821). The measurement technique adopts the storage ring concept used for E821, with magic-momentum muons stored in a highly uniform 1.45 T magnetic dipole field. The spin precession frequency is extracted from an analysis of the modulation of the rate of higher-energy positrons from muon decays, detected by 24 calorimeters and 3 straw tracking detectors. Compared to the E821 experiment, muon beammore » preparation, storage ring internal hardware, field measuring equipment, and detector and electronics systems are all new or significantly upgraded. Herein, I report on the status of the experiment as of Sept. 2016, presenting the magnetic field uniformity results after the completion of the first round of shimming and outlining the construction progress of the main detector systems.« less

The Muon g $-$ 2 experiment at Fermilab

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mott, James

Here, the Muon g-2 experiment at Fermilab will measure the anomalous magnetic moment of the muon to a precision of 140 ppb, reducing the experimental uncertainty by a factor of 4 compared to the previous measurement at BNL (E821). The measurement technique adopts the storage ring concept used for E821, with magic-momentum muons stored in a highly uniform 1.45 T magnetic dipole field. The spin precession frequency is extracted from an analysis of the modulation of the rate of higher-energy positrons from muon decays, detected by 24 calorimeters and 3 straw tracking detectors. Compared to the E821 experiment, muon beammore » preparation, storage ring internal hardware, field measuring equipment, and detector and electronics systems are all new or significantly upgraded. Herein, I report on the status of the experiment as of Sept. 2016, presenting the magnetic field uniformity results after the completion of the first round of shimming and outlining the construction progress of the main detector systems.« less

20 CFR 653.503 - Field checks.

Code of Federal Regulations, 2014 CFR

2014-04-01

... to appropriate enforcement agencies in writing. (b) State agencies, to the maximum extent possible... enforcement agencies. State agencies shall report difficulties in making such formal or informal arrangements...

20 CFR 653.503 - Field checks.

Code of Federal Regulations, 2012 CFR

2012-04-01

... to appropriate enforcement agencies in writing. (b) State agencies, to the maximum extent possible... enforcement agencies. State agencies shall report difficulties in making such formal or informal arrangements...

20 CFR 653.503 - Field checks.

Code of Federal Regulations, 2011 CFR

2011-04-01

... to appropriate enforcement agencies in writing. (b) State agencies, to the maximum extent possible... enforcement agencies. State agencies shall report difficulties in making such formal or informal arrangements...

20 CFR 653.503 - Field checks.

Code of Federal Regulations, 2013 CFR

2013-04-01

... to appropriate enforcement agencies in writing. (b) State agencies, to the maximum extent possible... enforcement agencies. State agencies shall report difficulties in making such formal or informal arrangements...

Interpreting instructional cues in task switching procedures: the role of mediator retrieval.

PubMed

Logan, Gordon D; Schneider, Darryl W

2006-03-01

In 3 experiments the role of mediators in task switching with transparent and nontransparent cues was examined. Subjects switched between magnitude (greater or less than 5) and parity (odd or even) judgments of single digits. A cue-target congruency effect indicated mediator use: subjects responded faster to congruent cue-target combinations (e.g., ODD-3) than to incongruent cue-target combinations (e.g., ODD-4). Experiment 1 revealed significant congruency effects with transparent word cues (ODD, EVEN, HIGH, and LOW) and with relatively transparent letter cues (O, E, H, and L) but not with nontransparent letter cues (D, V, G, and W). Experiment 2 revealed significant congruency effects after subjects who were trained with nontransparent letter cues were informed of the relations between cues and word mediators halfway through the experiment. Experiment 3 showed that congruency effects with relatively transparent letter cues diminished over 10 sessions of practice, suggesting that subjects used mediators less as practice progressed. The results are discussed in terms of the role of mediators in interpreting instructional cues.

What makes African American health disparities newsworthy? An experiment among journalists about story framing.

PubMed

Hinnant, Amanda; Oh, Hyun Jee; Caburnay, Charlene A; Kreuter, Matthew W

2011-12-01

News stories reporting race-specific health information commonly emphasize disparities between racial groups. But recent research suggests this focus on disparities has unintended effects on African American audiences, generating negative emotions and less interest in preventive behaviors (Nicholson RA, Kreuter MW, Lapka C et al. Unintended effects of emphasizing disparities in cancer communication to African-Americans. Cancer Epidemiol Biomarkers Prev 2008; 17: 2946-52). They found that black adults are more interested in cancer screening after reading about the progress African Americans have made in fighting cancer than after reading stories emphasizing disparities between blacks and whites. This study builds on past findings by (i) examining how health journalists judge the newsworthiness of stories that report race-specific health information by emphasizing disparities versus progress and (ii) determining whether these judgments can be changed by informing journalists of audience reactions to disparity versus progress framing. In a double-blind-randomized experiment, 175 health journalists read either a disparity- or progress-framed story on colon cancer, preceded by either an inoculation about audience effects of such framing or an unrelated (i.e. control) information stimuli. Journalists rated the disparity-frame story more favorably than the progress-frame story in every category of news values. However, the inoculation significantly increased positive reactions to the progress-frame story. Informing journalists of audience reactions to race-specific health information could influence how health news stories are framed.

44 CFR 65.3 - Requirement to submit new technical data.

Code of Federal Regulations, 2012 CFR

2012-10-01

... base flood elevations may increase or decrease resulting from physical changes affecting flooding... physical changes affecting flooding conditions, risk premium rates and flood plain management requirements...

44 CFR 65.3 - Requirement to submit new technical data.

Code of Federal Regulations, 2013 CFR

2013-10-01

... base flood elevations may increase or decrease resulting from physical changes affecting flooding... physical changes affecting flooding conditions, risk premium rates and flood plain management requirements...

44 CFR 65.3 - Requirement to submit new technical data.

Code of Federal Regulations, 2014 CFR

2014-10-01

... base flood elevations may increase or decrease resulting from physical changes affecting flooding... physical changes affecting flooding conditions, risk premium rates and flood plain management requirements...

36 CFR 65.3 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-07-01

..., corporations or public agencies holding fee simple title to property. “Owner” or “owners” does not include individuals, partnerships, corporations or public agencies holding easements or less than fee interests...

Electroproduction of K+ Λ at JLab Hall-C

NASA Astrophysics Data System (ADS)

Gogami, T.; Achenbach, P.; Ahmidouch, A.; Albayrak, I.; Androic, D.; Asaturyan, A.; Asaturyan, R.; Ates, O.; Baturin, P.; Badui, R.; Boeglin, W.; Bono, J.; Brash, E.; Carter, P.; Chen, C.; Chiba, A.; Christy, E.; Dalton, M.; Danagoulian, S.; De Leo, R.; Doi, D.; Elaasar, M.; Ent, R.; Fujii, Y.; Furic, M.; Gabrielyan, M.; Gan, L.; Garibaldi, F.; Gaskell, D.; Gasparian, A.; Hashimoto, O.; Horn, T.; Hu, B.; Hungerford, Ed. V.; Jones, M.; Kanda, H.; Kaneta, M.; Kato, S.; Kawai, M.; Kawama, D.; Khanal, H.; Kohl, M.; Liyanage, A.; Luo, W.; Maeda, K.; Margaryan, A.; Markowitz, P.; Maruta, T.; Matsumura, A.; Maxwell, V.; Mkrtchyan, A.; Mkrtchyan, H.; Nagao, S.; Nakamura, S. N.; Narayan, A.; Neville, C.; Niculescu, G.; Niculescu, M. I.; Nunez, A.; Nuruzzaman; Okayasu, Y.; Petkovic, T.; Pochodzalla, J.; Qiu, X.; Reinhold, J.; Rodriguez, V. M.; Samanta, C.; Sawatzky, B.; Seva, T.; Shichijo, A.; Tadevosyan, V.; Tang, L.; Taniya, N.; Tsukada, K.; Veilleux, M.; Vulcan, W.; Wesselmann, F. R.; Wood, S. A.; Yamamoto, T.; Ya, L.; Ye, Z.; Yokota, K.; Yuan, L.; Zhamkochyan, S.; Zhu, L.

2013-08-01

A Λ hypernuclear spectroscopic experiment, JLab E05-115 was performed at JLab Hall-C in 2009 by the (e, e'K+) reaction. Data of Λ hypernuclei with mass numbers from A = 7 to A = 52 were successfully taken, and the analyses are in progress. A polyethylene (CH2) target was used as a proton target to calibrate energy scales, and to study elementary process of the p(e, e'K+) Λ, Σ0 reaction. A preliminary differential cross section of K+ Λ electro-production at low Q2 [~0.01 (GeV/c)2] and at small kaon angles is reported in the present article.

Xanthomonas oryzae pv. oryzae RpfE Regulates Virulence and Carbon Source Utilization without Change of the DSF Production

PubMed Central

Cho, Jung-Hee; Yoon, Joo-Mi; Lee, Sang-Won; Noh, Young-Hee; Cha, Jae-Soon

2013-01-01

It has been known that most regulation of pathogenicity factor (rpf) genes in xanthomonads regulates virulence in response to the diffusible signal factor, DSF. Although many rpf genes have been functionally characterized, the function of rpfE is still unknown. We cloned the rpfE gene from a Xanthomonas oryzae pv. oryzae (Xoo) Korean race KACC10859 and generated mutant strains to elucidate the role of RpfE with respect to the rpf system. Through experiments using the rpfE-deficient mutant strain, we found that mutation in rpfE gene in Xoo reduced virulence, swarm motility, and production of virulence factors such as cellulase and extracellular polysaccharide. Disease progress by the rpfE-deficient mutant strain was significantly slowed compared to disease progress by the wild type and the number of the rpfE-deficient mutant strain was lower than that of the wild type in the early phase of infection in the inoculated rice leaf. The rpfE mutant strain was unable to utilize sucrose or xylose as carbon sources efficiently in culture. The mutation in rpfE, however, did not affect DSF synthesis. Our results suggest that the rpfE gene regulates the virulence of Xoo under different nutrient conditions without change of DSF production. PMID:25288965

Spaceflight of HUVEC: An Integrated eXperiment- SPHINX Onboard the ISS

NASA Astrophysics Data System (ADS)

Versari, S.; Maier, J. A. M.; Norfini, A.; Zolesi, V.; Bradamante, S.

2013-02-01

The spaceflight orthostatic challenge can promote in astronauts inadequate cardiovascular responses defined as cardiovascular deconditioning. In particular, disturbance of endothelial functions are known to lead to altered vascular performances, being the endothelial cells crucial in the maintenance of the functional integrity of the vascular wall. In order to evaluate whether weightlessness affects endothelial functions, we designed, developed, and performed the experiment SPHINX - SPaceflight of HUVEC: an INtegrated eXperiment - where HUVEC (Human Umbilical Vein Endothelial Cells) were selected as a macrovascular cell model system. SPHINX arrived at the International Space Station (ISS) onboard Progress 40P, and was processed inside Kubik 6 incubator for 7 days. At the end, all of the samples were suitably fixed and preserved at 6°C until return on Earth on Soyuz 23S.

Robotic general surgery experience: a gradual progress from simple to more complex procedures.

PubMed

Al-Naami, M; Anjum, M N; Aldohayan, A; Al-Khayal, K; Alkharji, H

2013-12-01

Robotic surgery was introduced at our institution in 2003, and we used a progressive approach advancing from simple to more complex procedures. A retrospective chart review. Cases included totalled 129. Set-up and operative times have improved over time and with experience. Conversion rates to standard laparoscopic or open techniques were 4.7% and 1.6%, respectively. Intraoperative complications (6.2%), blood loss and hospital stay were directly proportional to complexity. There were no mortalities and the postoperative complication rate (13.2%) was within accepted norms. Our findings suggest that robot technology is presently most useful in cases tailored toward its advantages, i.e. those confined to a single space, those that require performance of complex tasks, and re-do procedures. Copyright © 2013 John Wiley & Sons, Ltd.

Production of High Harmonic X-ray Radiation from Non-linear Thomson Scattering at LLNL PLEIADES

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lim, J; Doyuran, A; Frigola, P

2005-05-17

We describe an experiment for production of high harmonic x-ray radiation from Thomson backscattering of an ultra-short high power density laser by a relativistic electron beam at the PLEIADES facility at LLNL. In this scenario, electrons execute a ''figure-8'' motion under the influence of the high-intensity laser field, where the constant characterizing the field strength is expected to exceed unity: a{sub L} = eE{sub L}/m{sub e}cw{sub L} {ge} 1. With large a{sub L} this motion produces high harmonic x-ray radiation and significant broadening of the spectral peaks. This paper is intended to give a layout of the PLEIADES experiment, alongmore » with progress towards experimental goals.« less

20 CFR 653.100 - Purpose and scope of subpart.

Code of Federal Regulations, 2010 CFR

2010-04-01

... seasonal farmworkers (MSFWs) on a basis which is qualitatively equivalent and quantitatively proportionate to services provided to non-MSFWs. It also contains requirements that State agencies establish a...

20 CFR 653.100 - Purpose and scope of subpart.

Code of Federal Regulations, 2012 CFR

2012-04-01

... seasonal farmworkers (MSFWs) on a basis which is qualitatively equivalent and quantitatively proportionate to services provided to non-MSFWs. It also contains requirements that State agencies establish a...

20 CFR 653.100 - Purpose and scope of subpart.

Code of Federal Regulations, 2014 CFR

2014-04-01

... seasonal farmworkers (MSFWs) on a basis which is qualitatively equivalent and quantitatively proportionate to services provided to non-MSFWs. It also contains requirements that State agencies establish a...

Autoimmune hepatitis in children: progression of 20 cases in northern Mexico.

PubMed

Nares-Cisneros, J; Jaramillo-Rodríguez, Y

2014-01-01

Autoimmune hepatitis (AIH) is a chronic inflammatory disease of the liver with nonspecific clinical manifestations that causes greater liver damage in children than in adults. To analyze the clinical progression, biochemical profiles, histopathologic changes, and treatment response in 20 children with AIH. A retrospective study was carried out on the variables associated with clinical progression, diagnosis, and treatment response in children seen at the the Unidad Médica de Alta Especialidad (UMAE) No. 71 IMSS in Torreón, Coahuila, Mexico, from 1992 to 2012. Twenty patients were analyzed, 75% with type 1 AIH (AIH-1) and 25% with type 2 AIH (AIH-2). Girls predominated with a 3:1 ratio of girls to boys. The mean age was 10.07 ± 6.53 years for the AIH-1 cases and 6.75 ± 3.77 years for the AIH-2 cases. There was an association with immunologic diseases in 40% of the patients. The patients in the AIH-2 group had greater biochemical profile alterations and IgA deficiency. Anti-nuclear antibody and anti-smooth muscle antibody were positive in 100% of the patients with AIH-1, and anti-liver kidney microsomal type 1 antibody was positive in 100% of the AIH-2 patients. Liver biopsy revealed interface hepatitis in both groups. The AIH-2 group responded more quickly to treatment, but had a higher recurrence rate. Autoimmune hepatitis in the pediatric patient should be suspected in order to make an early diagnosis and thereby establish opportune treatment. Determining the type of AIH is necessary for making adequate diagnosis and for achieving a better outcome in relation to recurrence and complication rates. Copyright © 2014 Asociación Mexicana de Gastroenterología. Published by Masson Doyma México S.A. All rights reserved.

Modeling of fugitive dust emission for construction sand and gravel processing plant.

PubMed

Lee, C H; Tang, L W; Chang, C T

2001-05-15

Due to rapid economic development in Taiwan, a large quantity of construction sand and gravel is needed to support domestic civil construction projects. However, a construction sand and gravel processing plant is often a major source of air pollution, due to its associated fugitive dust emission. To predict the amount of fugitive dust emitted from this kind of processing plant, a semiempirical model was developed in this study. This model was developed on the basis of the actual dust emission data (i.e., total suspended particulate, TSP) and four on-site operating parameters (i.e., wind speed (u), soil moisture (M), soil silt content (s), and number (N) of trucks) measured at a construction sand and gravel processing plant. On the basis of the on-site measured data and an SAS nonlinear regression program, the expression of this model is E = 0.011.u2.653.M-1.875.s0.060.N0.896, where E is the amount (kg/ton) of dust emitted during the production of each ton of gravel and sand. This model can serve as a facile tool for predicting the fugitive dust emission from a construction sand and gravel processing plant.

Is the virulence of HIV changing? A meta-analysis of trends in prognostic markers of HIV disease progression and transmission

PubMed Central

Herbeck, Joshua T.; Müller, Viktor; Maust, Brandon S.; Ledergerber, Bruno; Torti, Carlo; Di Giambenedetto, Simona; Gras, Luuk; Günthard, Huldrych F.; Jacobson, Lisa P.; Mullins, James I.; Gottlieb, Geoffrey S.

2013-01-01

Objective The potential for changing HIV-1 virulence has significant implications for the AIDS epidemic, including changing HIV transmission rates, rapidity of disease progression, and timing of ART. Published data to date have provided conflicting results. Design We conducted a meta-analysis of changes in baseline CD4+ T-cell counts and set point plasma viral RNA load over time in order to establish whether summary trends are consistent with changing HIV-1 virulence. Methods We searched PubMed for studies of trends in HIV-1 prognostic markers of disease progression and supplemented findings with publications referenced in epidemiological or virulence studies. We identified 12 studies of trends in baseline CD4+ T-cell counts (21 052 total individuals), and eight studies of trends in set point viral loads (10 785 total individuals), spanning the years 1984–2010. Using random-effects meta-analysis, we estimated summary effect sizes for trends in HIV-1 plasma viral loads and CD4+ T-cell counts. Results Baseline CD4+ T-cell counts showed a summary trend of decreasing cell counts [effect=−4.93 cells/µl per year, 95% confidence interval (CI) −6.53 to −3.3]. Set point viral loads showed a summary trend of increasing plasma viral RNA loads (effect=0.013 log10 copies/ml per year, 95% CI −0.001 to 0.03). The trend rates decelerated in recent years for both prognostic markers. Conclusion Our results are consistent with increased virulence of HIV-1 over the course of the epidemic. Extrapolating over the 30 years since the first description of AIDS, this represents a CD4+ T cells loss of approximately 148 cells/µl and a gain of 0.39 log10 copies/ml of viral RNA measured during early infection. These effect sizes would predict increasing rates of disease progression, and need for ART as well as increasing transmission risk. PMID:22089381

Phase III, Randomized, Double-Blind, Multicenter Trial Comparing Orteronel (TAK-700) Plus Prednisone With Placebo Plus Prednisone in Patients With Metastatic Castration-Resistant Prostate Cancer That Has Progressed During or After Docetaxel-Based Therapy: ELM-PC 5

PubMed Central

Fizazi, Karim; Jones, Robert; Oudard, Stephane; Efstathiou, Eleni; Saad, Fred; de Wit, Ronald; De Bono, Johann; Cruz, Felipe Melo; Fountzilas, George; Ulys, Albertas; Carcano, Flavio; Agarwal, Neeraj; Agus, David; Bellmunt, Joaquim; Petrylak, Daniel P.; Lee, Shih-Yuan; Webb, Iain J.; Tejura, Bindu; Borgstein, Niels; Dreicer, Robert

2015-01-01

Purpose Orteronel (TAK-700) is an investigational, nonsteroidal, reversible, selective 17,20-lyase inhibitor. This study examined orteronel in patients with metastatic castration-resistant prostate cancer that progressed after docetaxel therapy. Patients and Methods In our study, 1,099 men were randomly assigned in a 2:1 schedule to receive orteronel 400 mg plus prednisone 5 mg twice daily or placebo plus prednisone 5 mg twice daily, stratified by region (Europe, North America [NA], and non-Europe/NA) and Brief Pain Inventory–Short Form worst pain score. Primary end point was overall survival (OS). Key secondary end points (radiographic progression-free survival [rPFS], ≥ 50% decrease of prostate-specific antigen [PSA50], and pain response at 12 weeks) were to undergo statistical testing only if the primary end point analysis was significant. Results The study was unblinded after crossing a prespecified OS futility boundary. The median OS was 17.0 months versus 15.2 months with orteronel-prednisone versus placebo-prednisone (hazard ratio [HR], 0.886; 95% CI, 0.739 to 1.062; P = .190). Improved rPFS was observed with orteronel-prednisone (median, 8.3 v 5.7 months; HR, 0.760; 95% CI, 0.653 to 0.885; P < .001). Orteronel-prednisone showed advantages over placebo-prednisone in PSA50 rate (25% v 10%, P < .001) and time to PSA progression (median, 5.5 v 2.9 months, P < .001) but not pain response rate (12% v 9%; P = .128). Adverse events (all grades) were generally more frequent with orteronel-prednisone, including nausea (42% v 26%), vomiting (36% v 17%), fatigue (29% v 23%), and increased amylase (14% v 2%). Conclusion Our study did not meet the primary end point of OS. Longer rPFS and a higher PSA50 rate with orteronel-prednisone indicate antitumor activity. PMID:25624429

Assimilation approach to measuring organizational change from pre- to post-intervention

PubMed Central

Moore, Scott C; Osatuke, Katerine; Howe, Steven R

2014-01-01

AIM: To present a conceptual and measurement strategy that allows to objectively, sensitively evaluate intervention progress based on data of participants’ perceptions of presenting problems. METHODS: We used as an example an organization development intervention at a United States Veterans Affairs medical center. Within a year, the intervention addressed the hospital’s initially serious problems and multiple stakeholders (employees, management, union representatives) reported satisfaction with progress made. Traditional quantitative outcome measures, however, failed to capture the strong positive impact consistently reported by several types of stakeholders in qualitative interviews. To address the paradox, full interview data describing the medical center pre- and post- intervention were examined applying a validated theoretical framework from another discipline: Psychotherapy research. The Assimilation model is a clinical-developmental theory that describes empirically grounded change levels in problematic experiences, e.g., problems reported by participants. The model, measure Assimilation of Problematic Experiences Scale (APES), and rating procedure have been previously applied across various populations and problem types, mainly in clinical but also in non-clinical settings. We applied the APES to the transcribed qualitative data of intervention participants’ interviews, using the method closely replicating prior assimilation research (the process whereby trained clinicians familiar with the Assimilation model work with full, transcribed interview data to assign the APES ratings). The APES ratings summarized levels of progress which was defined as participants’ assimilation level of problematic experiences, and compared from pre- to post-intervention. RESULTS: The results were consistent with participants’ own reported perceptions of the intervention impact. Increase in APES levels from pre- to post-intervention suggested improvement, missed in the previous quantitative measures (the Maslach Burnout Inventory and the Work Environment Scale). The progress specifically consisted of participants’ moving from the APES stages where the problematic experience was avoided, to the APES stages where awareness and attention to the problems were steadily sustained, although the problems were not yet fully processed or resolved. These results explain why the conventional outcome measures failed to reflect the intervention progress; they narrowly defined progress as resolution of the presenting problems and alleviation of symptomatic distress. In the Assimilation model, this definition only applies to a sub-segment of the change continuum, specifically the latest APES stages. The model defines progress as change in psychological processes used in response to the problem, i.e., a growing ability to deal with problematic issues non-defensively, manifested differently depending on APES stages. At early stages, progress is an increased ability to face the problem rather than turning away. At later APES stages, progress involves naming, understanding and successfully addressing the problem. The assimilation approach provides a broader developmental context compared to exclusively symptom, problem-, or behavior- focused approaches that typically inform outcome measurement in interpersonally based interventions. In our data, this made the difference between reflecting (APES) vs missing (Maslach Burnout Inventory, Work Environment Scale) the pre-post change that was strongly perceived by the intervention recipients. CONCLUSION: The results illustrated a working solution to the challenge of objectively evaluating progress in subjectively experienced problems. This approach informs measuring change in psychologically based interventions. PMID:24660141

The importance of need for cognition and educational experience in enhanced and standard substance abuse treatment.

PubMed

Czuchry, Michael; Dansereau, Donald F

2004-06-01

The current study examined the relationship between need for cognition (i.e., cognitive motivation or "will") and educational experience (i.e., cognitive ability or "skill") to perceived improvements during treatment of probationers receiving residential treatment within the criminal justice system. Probationers were randomly assigned to either receive motivational activities developed by the authors (the "enhanced" condition), or treatment as usual (but with access to general reading materials in lieu of the motivational activities). Need for cognition and educational experience were assessed and used as blocking variables, and ratings of progress were assessed midway and toward the end of treatment. The results indicate that both need for cognition and educational experience are important predictors of improvement during treatment, and that the motivational activities developed by the authors were particularly valuable for clients with lower levels of need for cognition.

Baseline Serum Estradiol and Fracture Reduction During Treatment With Hormone Therapy: The Women’s Health Initiative Randomized Trial

PubMed Central

Cauley, Jane A.; LaCroix, Andrea Z.; Robbins, John A.; Larson, Joseph; Wallace, Robert; Wactawski-Wende, Jean; Chen, Zhao; Bauer, Douglas C.; Cummings, Steven R.; Jackson, Rebecca

2009-01-01

Purpose To test the hypothesis that the reduction in fractures with hormone therapy (HT) is greater in women with lower estradiol levels. Methods We conducted a nested case-control study within the Women’s Health Initiative HT Trials. The sample included 231 hip fracture case-control pairs and a random sample of 519 all fracture case-control pairs. Cases and controls were matched for age, ethnicity, randomization date, fracture history and hysterectomy status. Hormones were measured prior to randomization. Incident cases of fracture identified over an average follow-up of 6.53 years. Results There was no evidence that the effect of HT on fracture differed by baseline estradiol (E2) or sex hormone binding globulin (SHBG). Across all quartiles of E2 and SHBG, women randomized to HT had about a 50% lower risk of fracture including hip fracture, compared to placebo. Conclusion The effect of HT on fracture reduction is independent of estradiol and SHBG levels. PMID:19436934

20 CFR 653.103 - MSFW job applications.

Code of Federal Regulations, 2010 CFR

2010-04-01

..., this explanation shall be made in Spanish, if necessary or requested during any period of substantial... English and Spanish and shall specify those services which are available after completion of a full...

FY92 Progress Report for the Gyrotron Backward-Wave-Oscillator Experiment

DTIC Science & Technology

1993-07-01

C. SAMPLE CABLE CALIBRATION 23 D. ASYST CHANNEL SETUPS 26 E. SAMPLE MAGNET INPUT DATA DECK FOR THE GYRO-BWO 32 F. SAMPLE EGUN INPUT DATA DECK FOR THE...of the first coil of the Helmholtz pair; zero also corresponds to the diode end of the experiment). Another computer code used was the EGUN code (Ref...a short computer program was written to superimpose the two magnetic fields; DC and Helmholtz). An example of an EGUN input data file is included in

RTEMS Centre - Support and Maintenance Centre to RTEMS Operating System

NASA Astrophysics Data System (ADS)

Silva, H.; Constantino, A.; Freitas, D.; Coutinho, M.; Faustino, S.; Mota, M.; Colaço, P.; Sousa, J.; Dias, L.; Damjanovic, B.; Zulianello, M.; Rufino, J.

2009-05-01

RTEMS CENTRE - Support and Maintenance Centre to RTEMS Operating System is a joint ESA/Portuguese Task Force initiative to develop a support and maintenance centre to the Real-Time Executive for Multiprocessor Systems (RTEMS). This paper gives a high level visibility of the progress, the results obtained and the future work in the RTEMS CENTRE [6] and in the RTEMS Improvement [7] projects. RTEMS CENTRE started officially in November 2006, with the RTEMS 4.6.99.2 version. A full analysis of RTEMS operating system was produced. The architecture was analysed in terms of conceptual, organizational and operational concepts. The original objectives [1] of the centre were primarily to create and maintain technical expertise and competences in this RTOS, to develop a website to provide the European Space Community an entry point for obtaining support (http://rtemscentre.edisoft.pt), to design, develop, maintain and integrate some RTEMS support tools (Timeline Tool, Configuration and Management Tools), to maintain flight libraries and Board Support Packages, to develop a strong relationship with the World RTEMS Community and finally to produce some considerations in ARINC-653, DO-178B and ECSS E-40 standards. RTEMS Improvement is the continuation of the RTEMS CENTRE. Currently the RTEMS, version 4.8.0, is being facilitated for a future qualification. In this work, the validation material is being produced following the Galileo Software Standards Development Assurance Level B [5]. RTEMS is being completely tested, errors analysed, dead and deactivated code removed and tests produced to achieve 100% statement and decision coverage of source code [2]. The SW to exploit the LEON Memory Management Unit (MMU) hardware will be also added. A brief description of the expected implementations will be given.

Image-guided, intensity-modulated radiation therapy (IG-IMRT) for skull base chordoma and chondrosarcoma: preliminary outcomes.

PubMed

Sahgal, Arjun; Chan, Michael W; Atenafu, Eshetu G; Masson-Cote, Laurence; Bahl, Gaurav; Yu, Eugene; Millar, Barbara-Ann; Chung, Caroline; Catton, Charles; O'Sullivan, Brian; Irish, Jonathan C; Gilbert, Ralph; Zadeh, Gelareh; Cusimano, Michael; Gentili, Fred; Laperriere, Normand J

2015-06-01

We report our preliminary outcomes following high-dose image-guided intensity modulated radiotherapy (IG-IMRT) for skull base chordoma and chondrosarcoma. Forty-two consecutive IG-IMRT patients, with either skull base chordoma (n = 24) or chondrosarcoma (n = 18) treated between August 2001 and December 2012 were reviewed. The median follow-up was 36 months (range, 3-90 mo) in the chordoma cohort, and 67 months (range, 15-125) in the chondrosarcoma cohort. Initial surgery included biopsy (7% of patients), subtotal resection (57% of patients), and gross total resection (36% of patients). The median IG-IMRT total doses in the chondrosarcoma and chordoma cohorts were 70 Gy and 76 Gy, respectively, delivered with 2 Gy/fraction. For the chordoma and chondrosarcoma cohorts, the 5-year overall survival and local control rates were 85.6% and 65.3%, and 87.8% and 88.1%, respectively. In total, 10 patients progressed locally: 8 were chordoma patients and 2 chondrosarcoma patients. Both chondrosarcoma failures were in higher-grade tumors (grades 2 and 3). None of the 8 patients with grade 1 chondrosarcoma failed, with a median follow-up of 77 months (range, 34-125). There were 8 radiation-induced late effects-the most significant was a radiation-induced secondary malignancy occurring 6.7 years following IG-IMRT. Gross total resection and age were predictors of local control in the chordoma and chondrosarcoma patients, respectively. We report favorable survival, local control and adverse event rates following high dose IG-IMRT. Further follow-up is needed to confirm long-term efficacy. © The Author(s) 2014. Published by Oxford University Press on behalf of the Society for Neuro-Oncology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

49 CFR 194.105 - Worst case discharge.

Code of Federal Regulations, 2013 CFR

2013-10-01

...: Prevention measure Standard Credit(percent) Secondary containment >100% NFPA 30 50 Built/repaired to API standards API STD 620/650/653 10 Overfill protection standards API RP 2350 5 Testing/cathodic protection API...

49 CFR 194.105 - Worst case discharge.

Code of Federal Regulations, 2010 CFR

2010-10-01

...: Prevention measure Standard Credit(percent) Secondary containment > 100% NFPA 30 50 Built/repaired to API standards API STD 620/650/653 10 Overfill protection standards API RP 2350 5 Testing/cathodic protection API...

49 CFR 194.105 - Worst case discharge.

Code of Federal Regulations, 2014 CFR

2014-10-01

...: Prevention measure Standard Credit(percent) Secondary containment >100% NFPA 30 50 Built/repaired to API standards API STD 620/650/653 10 Overfill protection standards API RP 2350 5 Testing/cathodic protection API...

49 CFR 194.105 - Worst case discharge.

Code of Federal Regulations, 2012 CFR

2012-10-01

...: Prevention measure Standard Credit(percent) Secondary containment > 100% NFPA 30 50 Built/repaired to API standards API STD 620/650/653 10 Overfill protection standards API RP 2350 5 Testing/cathodic protection API...

49 CFR 194.105 - Worst case discharge.

Code of Federal Regulations, 2011 CFR

2011-10-01

...: Prevention measure Standard Credit(percent) Secondary containment > 100% NFPA 30 50 Built/repaired to API standards API STD 620/650/653 10 Overfill protection standards API RP 2350 5 Testing/cathodic protection API...

Child abuse, early maladaptive schemas, and risky sexual behavior in college women.

PubMed

Roemmele, Melissa; Messman-Moore, Terri L

2011-05-01

Previous research suggests that individuals abused as children are more likely to engage in risky sexual behavior during adulthood. The present study examined early maladaptive schemas as mediators of the child abuse-risky sexual behavior relationship among 653 college women. Self-report surveys assessed three forms of child abuse: Sexual, physical, and emotional, and assessed early maladaptive schemas within two domains: Disconnection/rejection and Other-Directedness. Disconnection/rejection schemas fully mediated the relation between child emotional abuse and number of sexual partners and partially mediated the relationship for sexual and physical abuse. However, when frequency of specific risky sexual acts (e.g., sex without contraception) was examined in the previous six months, only abandonment was a partial mediator. Implications for intervention and future research are discussed.

Stable sustainment of plasmas with electron internal transport barrier by ECH in the LHD

NASA Astrophysics Data System (ADS)

Yoshimura, Y.; Kasahara, H.; Tokitani, M.; Sakamoto, R.; Ueda, Y.; Marushchenko, N. B.; Seki, R.; Kubo, S.; Shimozuma, T.; Igami, H.; Takahashi, H.; Tsujimura, T. I.; Makino, R.; Kobayashi, S.; Ito, S.; Mizuno, Y.; Okada, K.; Akiyama, T.; Tanaka, K.; Tokuzawa, T.; Yamada, I.; Yamada, H.; Mutoh, T.; Takeiri, Y.; the LHD Experiment Group

2018-02-01

The long pulse experiments in the Large Helical Device has made progress in sustainment of improved confinement states. It was found that steady-state sustainment of the plasmas with improved confinement at the core region, that is, electron internal transport barrier (e-ITB), was achieved with no significant difficulty. Sustainment of a plasma having e-ITB with the line average electron density n e_ave of 1.1 × 1019 m-3 and the central electron temperature T e0 of ˜3.5 keV for longer than 5 min only with 340 kW ECH power was successfully demonstrated.

Final Report. Grant DOE DE-FG02-04ER54768

DOE Office of Scientific and Technical Information (OSTI.GOV)

Betti, Riccardo

The magnetized spherical implosion campaign funded by this grant is summarized in this progress report. The main goal of this grant was to improve the seed eld generator MIFEDS (Magneto- Inertial Fusion Energy Delivery System) on the OMEGA laser to enable experiments at high elds (> 8 T) and to carry out magnetized spherical implosion experiments to study the e ect of magnetic elds on the fusion yield. New experiments were carried out in the last budget period to study the e ect of higher elds and shaped laser pulses. These new experiments improved the magnetized implosion database and allowedmore » us to improve the con dence of our conclusions with respect to the e ect of magnetic elds on implosion performance. The main conclusion is that adding magnetic eld leads to a 30% higher neutron yield, but using seed magnetic eld higher than 8 T does not further increase the neutron yield. A further conclusion is that the yield enhancement due to the magnetic eld is approximately independent of the laser pulse shape.« less

Association between self-efficacy, career interest and rural career intent in Australian medical students with rural clinical school experience

PubMed Central

Isaac, Vivian; Walters, Lucie; McLachlan, Craig S

2015-01-01

Objectives To investigate medical student's self-efficacy at the time of finishing their rural clinical school (RCS) placement and factors associated with self-efficacy. Secondary aims are to explore whether interest levels or self-efficacy are associated with rural or remote career intentions. Design, setting and participants A cross-sectional study of medical students who had completed their RCS term in 17 Australian universities. Data were derived from the 2013 Federation of Rural Australian Medical Educators (FRAME) evaluation survey. Questionnaire responses were analysed from 653 medical students from regional Australia. All 732 students who completed their RCS term in 2013 were invited to participate. Primary and secondary outcome measures Rural self-efficacy: Six questions to measure self-efficacy beliefs in rural medical practice, based on the sources of self-efficacy described by Bandura. Rural career intention: Students were asked to identify their preferred location for future practice. The options were, Capital or Major City; Inner regional city or large town; Smaller town and very remote area. Results Questionnaire responses were analysed from 653 medical students from regional Australia (response rate 89.2%). 83.8% of all students recalled an increase in their interest levels for rural medicine as a result of their RCS experience. Actual career intention to work in a regional area or rural area was 60.2%. Bivariate analyses showed female gender (p=0.003), rural background (p<0.001), an RCS preference for clinical training (p<0.001) and general practice intentions (p=0.004) were factors associated with higher levels of self-efficacy. Logistic regression analyses showed that self-efficacy was independently associated with increased interest in rural medicine (OR 1.4 (95% CI 1.3 to 1.5)) and rural career intent (OR 1.2 (95% CI 1.1 to 1.3)). (Model included gender, rural background, preference for RCS, generalist intent, rural practice interest and self-efficacy). Conclusions Self-efficacy is associated with increased interest levels for rural medicine and rural medical career intent. PMID:26671960

Association between self-efficacy, career interest and rural career intent in Australian medical students with rural clinical school experience.

PubMed

Isaac, Vivian; Walters, Lucie; McLachlan, Craig S

2015-12-15

To investigate medical student's self-efficacy at the time of finishing their rural clinical school (RCS) placement and factors associated with self-efficacy. Secondary aims are to explore whether interest levels or self-efficacy are associated with rural or remote career intentions. A cross-sectional study of medical students who had completed their RCS term in 17 Australian universities. Data were derived from the 2013 Federation of Rural Australian Medical Educators (FRAME) evaluation survey. Questionnaire responses were analysed from 653 medical students from regional Australia. All 732 students who completed their RCS term in 2013 were invited to participate. Rural self-efficacy: Six questions to measure self-efficacy beliefs in rural medical practice, based on the sources of self-efficacy described by Bandura. Rural career intention: Students were asked to identify their preferred location for future practice. The options were, Capital or Major City; Inner regional city or large town; Smaller town and very remote area. Questionnaire responses were analysed from 653 medical students from regional Australia (response rate 89.2%). 83.8% of all students recalled an increase in their interest levels for rural medicine as a result of their RCS experience. Actual career intention to work in a regional area or rural area was 60.2%. Bivariate analyses showed female gender (p=0.003), rural background (p<0.001), an RCS preference for clinical training (p<0.001) and general practice intentions (p=0.004) were factors associated with higher levels of self-efficacy. Logistic regression analyses showed that self-efficacy was independently associated with increased interest in rural medicine (OR 1.4 (95% CI 1.3 to 1.5)) and rural career intent (OR 1.2 (95% CI 1.1 to 1.3)). (Model included gender, rural background, preference for RCS, generalist intent, rural practice interest and self-efficacy). Self-efficacy is associated with increased interest levels for rural medicine and rural medical career intent. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

Maximum Likelihood Analysis in the PEN Experiment

NASA Astrophysics Data System (ADS)

Lehman, Martin

2013-10-01

The experimental determination of the π+ -->e+ ν (γ) decay branching ratio currently provides the most accurate test of lepton universality. The PEN experiment at PSI, Switzerland, aims to improve the present world average experimental precision of 3 . 3 ×10-3 to 5 ×10-4 using a stopped beam approach. During runs in 2008-10, PEN has acquired over 2 ×107 πe 2 events. The experiment includes active beam detectors (degrader, mini TPC, target), central MWPC tracking with plastic scintillator hodoscopes, and a spherical pure CsI electromagnetic shower calorimeter. The final branching ratio will be calculated using a maximum likelihood analysis. This analysis assigns each event a probability for 5 processes (π+ -->e+ ν , π+ -->μ+ ν , decay-in-flight, pile-up, and hadronic events) using Monte Carlo verified probability distribution functions of our observables (energies, times, etc). A progress report on the PEN maximum likelihood analysis will be presented. Work supported by NSF grant PHY-0970013.

Caffeine exposure alters cardiac gene expression in embryonic cardiomyocytes

PubMed Central

Fang, Xiefan; Mei, Wenbin; Barbazuk, William B.; Rivkees, Scott A.

2014-01-01

Previous studies demonstrated that in utero caffeine treatment at embryonic day (E) 8.5 alters DNA methylation patterns, gene expression, and cardiac function in adult mice. To provide insight into the mechanisms, we examined cardiac gene and microRNA (miRNA) expression in cardiomyocytes shortly after exposure to physiologically relevant doses of caffeine. In HL-1 and primary embryonic cardiomyocytes, caffeine treatment for 48 h significantly altered the expression of cardiac structural genes (Myh6, Myh7, Myh7b, Tnni3), hormonal genes (Anp and BnP), cardiac transcription factors (Gata4, Mef2c, Mef2d, Nfatc1), and microRNAs (miRNAs; miR208a, miR208b, miR499). In addition, expressions of these genes were significantly altered in embryonic hearts exposed to in utero caffeine. For in utero experiments, pregnant CD-1 dams were treated with 20–60 mg/kg of caffeine, which resulted in maternal circulation levels of 37.3–65.3 μM 2 h after treatment. RNA sequencing was performed on embryonic ventricles treated with vehicle or 20 mg/kg of caffeine daily from E6.5-9.5. Differential expression (DE) analysis revealed that 124 genes and 849 transcripts were significantly altered, and differential exon usage (DEU) analysis identified 597 exons that were changed in response to prenatal caffeine exposure. Among the DE genes identified by RNA sequencing were several cardiac structural genes and genes that control DNA methylation and histone modification. Pathway analysis revealed that pathways related to cardiovascular development and diseases were significantly affected by caffeine. In addition, global cardiac DNA methylation was reduced in caffeine-treated cardiomyocytes. Collectively, these data demonstrate that caffeine exposure alters gene expression and DNA methylation in embryonic cardiomyocytes. PMID:25354728

What makes African American health disparities newsworthy? An experiment among journalists about story framing

PubMed Central

Hinnant, Amanda; Oh, Hyun Jee; Caburnay, Charlene A.; Kreuter, Matthew W.

2011-01-01

News stories reporting race-specific health information commonly emphasize disparities between racial groups. But recent research suggests this focus on disparities has unintended effects on African American audiences, generating negative emotions and less interest in preventive behaviors (Nicholson RA, Kreuter MW, Lapka C et al. Unintended effects of emphasizing disparities in cancer communication to African-Americans. Cancer Epidemiol Biomarkers Prev 2008; 17: 2946–52). They found that black adults are more interested in cancer screening after reading about the progress African Americans have made in fighting cancer than after reading stories emphasizing disparities between blacks and whites. This study builds on past findings by (i) examining how health journalists judge the newsworthiness of stories that report race-specific health information by emphasizing disparities versus progress and (ii) determining whether these judgments can be changed by informing journalists of audience reactions to disparity versus progress framing. In a double-blind-randomized experiment, 175 health journalists read either a disparity- or progress-framed story on colon cancer, preceded by either an inoculation about audience effects of such framing or an unrelated (i.e. control) information stimuli. Journalists rated the disparity-frame story more favorably than the progress-frame story in every category of news values. However, the inoculation significantly increased positive reactions to the progress-frame story. Informing journalists of audience reactions to race-specific health information could influence how health news stories are framed. PMID:21911844

Lif Spectroscopy of ThF and the Preparation of ThF^{+} for the Jila eEDM Experiment

NASA Astrophysics Data System (ADS)

Ng, Kia Boon; Zhou, Yan; Gresh, Dan; Cairncross, William; Roussy, Tanya; Shagam, Yuval; Cheng, Lan; Ye, Jun; Cornell, Eric

2017-06-01

ThF^{+} is a promising candidate for a second-generation molecular ion-based measurement of the permanent electric dipole moment of the electron (eEDM). Compared to the current HfF^{+} eEDM experiment, ThF^{+} has several advantages: (i) the eEDM-sensitive ^{3}Δ_1 electronic state is the ground state, which facilitates a long measurement coherence time; (ii) its effective electric field (38 GV/cm) is 50% larger than that of HfF+, which promises a direct increase of the eEDM sensitivity; and (iii) the ionization energy of neutral ThF is lower than its dissociation energy, which introduces a greater flexibility for rotational state-selective photoionization via core-nonpenetrating Rydberg states. We use laser-induced fluorescence (LIF) spectroscopy to find suitable intermediate states required for the state selective ionization process. We present the results of our LIF spectroscopy of ThF, and our current progress on efficient ThF ionization and on ThF^{+} dissociation.

Tales of conjugation and sex pheromones

PubMed Central

2011-01-01

This review covers highlights of the author's experience becoming and working as a plasmid biologist. The account chronicles a progression from studies of ColE1 DNA in Escherichia coli to Gram-positive bacteria with an emphasis on conjugation in enterococci. It deals with gene amplification, conjugative transposons and sex pheromones in the context of bacterial antibiotic resistance. PMID:22016844

Airlock Battery Charge module

NASA Image and Video Library

2008-06-06

S124-E-006865 (6 June 2008) --- One of a series of digital still images documenting the Japanese Experiment Module, or JEM, also called Kibo, in its new home on the International Space Station, this view features Kibo's exterior, Earth's horizon and a couple of "visiting" spacecraft. The Space Shuttle Discovery and a Russian Progress resupply craft are seen near foreground.

20 CFR 653.110 - Disclosure of data.

Code of Federal Regulations, 2010 CFR

2010-04-01

... made to the ETA national or regional office, the ETA shall forward the request to the State agency for... State agency and the ETA, however, to the extent that they contain statements of opinion rather than...

7 CFR 653.2 - Technical standards and criteria.

Code of Federal Regulations, 2011 CFR

2011-01-01

... guidance and direction needed to assure that the practices meet the intended purpose and are of the quality needed to assure lasting for the design life. Standards and criteria are developed in consultation with...

7 CFR 653.2 - Technical standards and criteria.

Code of Federal Regulations, 2014 CFR

2014-01-01

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7 CFR 653.2 - Technical standards and criteria.

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2010-01-01

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7 CFR 653.2 - Technical standards and criteria.

Code of Federal Regulations, 2013 CFR

2013-01-01

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7 CFR 653.2 - Technical standards and criteria.

Code of Federal Regulations, 2012 CFR

2012-01-01

... guidance and direction needed to assure that the practices meet the intended purpose and are of the quality needed to assure lasting for the design life. Standards and criteria are developed in consultation with...

38 CFR 3.653 - Foreign residence.

Code of Federal Regulations, 2014 CFR

2014-07-01

.... There is no time limit for filing claim. (d) Germany and Japan. Where payments were discontinued before July 1, 1954, because the payee was a citizen or subject of Germany or Japan, no payments will be made...

38 CFR 3.653 - Foreign residence.

Code of Federal Regulations, 2013 CFR

2013-07-01

.... There is no time limit for filing claim. (d) Germany and Japan. Where payments were discontinued before July 1, 1954, because the payee was a citizen or subject of Germany or Japan, no payments will be made...

38 CFR 3.653 - Foreign residence.

Code of Federal Regulations, 2012 CFR

2012-07-01

.... There is no time limit for filing claim. (d) Germany and Japan. Where payments were discontinued before July 1, 1954, because the payee was a citizen or subject of Germany or Japan, no payments will be made...

38 CFR 3.653 - Foreign residence.

Code of Federal Regulations, 2011 CFR

2011-07-01

.... There is no time limit for filing claim. (d) Germany and Japan. Where payments were discontinued before July 1, 1954, because the payee was a citizen or subject of Germany or Japan, no payments will be made...

7 CFR 58.653 - Microbiological requirements for sherbet.

Code of Federal Regulations, 2011 CFR

2011-01-01

... requirements for sherbet. The finished product shall contain not more than 50,000 bacteria per gram as determined by the standard plate count and shall contain not more than 10 coliform organisms per gram in...

7 CFR 58.653 - Microbiological requirements for sherbet.

Code of Federal Regulations, 2010 CFR

2010-01-01

... requirements for sherbet. The finished product shall contain not more than 50,000 bacteria per gram as determined by the standard plate count and shall contain not more than 10 coliform organisms per gram in...

7 CFR 58.653 - Microbiological requirements for sherbet.

Code of Federal Regulations, 2013 CFR

2013-01-01

... requirements for sherbet. The finished product shall contain not more than 50,000 bacteria per gram as determined by the standard plate count and shall contain not more than 10 coliform organisms per gram in...

20 CFR 653.113 - Processing apparent violations.

Code of Federal Regulations, 2010 CFR

2010-04-01

... receipt of information regarding a suspected violation of employment related laws or JS regulations by an...) If the employer has filed a job order with the JS office within the past 12 months, the local office...

38 CFR 3.653 - Foreign residence.

Code of Federal Regulations, 2010 CFR

2010-07-01

.... There is no time limit for filing claim. (d) Germany and Japan. Where payments were discontinued before July 1, 1954, because the payee was a citizen or subject of Germany or Japan, no payments will be made...

49 CFR 195.432 - Inspection of in-service breakout tanks.

Code of Federal Regulations, 2014 CFR

2014-10-01

... low-pressure steel aboveground breakout tanks according to API Standard 653 (incorporated by reference... breakout tanks built to API Standard 2510 according to section 6 of API 510. (d) The intervals of...

49 CFR 195.432 - Inspection of in-service breakout tanks.

Code of Federal Regulations, 2012 CFR

2012-10-01

... low-pressure steel aboveground breakout tanks according to API Standard 653 (incorporated by reference... breakout tanks built to API Standard 2510 according to section 6 of API 510. (d) The intervals of...

49 CFR 195.432 - Inspection of in-service breakout tanks.

Code of Federal Regulations, 2011 CFR

2011-10-01

... low-pressure steel aboveground breakout tanks according to API Standard 653 (incorporated by reference... breakout tanks built to API Standard 2510 according to section 6 of API 510. (d) The intervals of...

49 CFR 195.432 - Inspection of in-service breakout tanks.

Code of Federal Regulations, 2010 CFR

2010-10-01

... low-pressure steel aboveground breakout tanks according to API Standard 653 (incorporated by reference... breakout tanks built to API Standard 2510 according to section 6 of API 510. (d) The intervals of...

49 CFR 195.432 - Inspection of in-service breakout tanks.

Code of Federal Regulations, 2013 CFR

2013-10-01

... low-pressure steel aboveground breakout tanks according to API Standard 653 (incorporated by reference... breakout tanks built to API Standard 2510 according to section 6 of API 510. (d) The intervals of...

Strange Particles and Heavy Ion Physics

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bassalleck, Bernd; Fields, Douglas

This very long-running grant has supported many experiments in nuclear and particle physics by a group from the University of New Mexico. The gamut of these experiments runs from many aspects of Strangeness Nuclear Physics, to rare Kaon decays, to searches for exotic Hadrons such as Pentaquark or H-Dibaryon, and finally to Spin Physics within the PHENIX collaboration at RHIC. These experiments were performed at a number of laboratories worldwide: first and foremost at Brookhaven National Lab (BNL), but also at CERN, KEK, and most recently at J-PARC. In this Final Technical Report we summarize progress and achievements for thismore » award since our last Progress Report, i.e. for the period of fall 2013 until the award’s termination on November 30, 2015. The report consists of two parts, representing our two most recent experimental efforts, participation in the Nucleon Spin Physics program of the PHENIX experiment at RHIC, the Relativistic Heavy Ion Collider at BNL – Task 1, led by Douglas Fields; and participation in several Strangeness Nuclear Physics experiments at J-PARC, the Japan Proton Accelerator Research Center in Tokai-mura, Japan – Task 2, led by Bernd Bassalleck.« less

PID techniques: Alternatives to RICH Methods

DOE Office of Scientific and Technical Information (OSTI.GOV)

Vavra, J.; /SLAC

2011-03-01

In this review article we discuss the recent progress in PID techniques other than the RICH methods. In particular we mention the recent progress in the Transition Radiation Detector (TRD), dE/dx cluster counting, and Time Of Flight (TOF) techniques. The TRD technique is mature and has been tried in many hadron colliders. It needs space though, about 20cm of detector radial space for every factor of 10 in the {pi}/e rejection power, and this tends to make such detectors large. Although the cluster counting technique is an old idea, it was never tried in a real physics experiment. Recently, theremore » are efforts to revive it for the SuperB experiment using He-based gases and waveform digitizing electronics. A factor of almost 2 improvement, compared to the classical dE/dx performance, is possible in principle. However, the complexity of the data analysis will be substantial. The TOF technique is well established, but introduction of new fast MCP-PMT and G-APD detectors creates new possibilities. It seems that resolutions below 20-30ps may be possible at some point in the future with relatively small systems, and perhaps this could be pushed down to 10-15ps with very small systems, assuming that one can solve many systematic issues. However, the cost, rate limitation, aging and cross-talk in multi-anode devices at high BW are problems. There are several groups working on these issues, so progress is likely. Table 6 summarizes the author's opinion of pros and cons of various detectors presented in this paper based on their operational capabilities. We refer the reader to Ref.40 for discussion of other more general limits from the PID point of view.« less

Examination of Potential Modifiers of the Association of APOL1 Alleles with CKD Progression

PubMed Central

Choi, Michael J.; Kao, W.H. Linda; Astor, Brad C.; Scialla, Julia J.; Appel, Lawrence J.; Li, Liang; Lipkowitz, Michael S.; Wolf, Myles; Parekh, Rulan S.; Winkler, Cheryl A.; Estrella, Michelle M.; Crews, Deidra C.

2015-01-01

Background and objectives Common apolipoprotein L1 (APOL1) variants are associated with increased risk of progressive CKD; however, not all individuals with high–risk APOL1 variants experience CKD progression. Identification of factors contributing to heterogeneity has important scientific and clinical implications. Design, setting, participants, & measurements Using multivariable Cox models, we analyzed data from 693 participants in the African American Study of Kidney Disease and Hypertension to identify factors that modify the association between APOL1 genotypes and CKD progression (doubling of serum creatinine or incident ESRD). Results Participant mean age was 54 years old, median GFR was 49 ml/min per 1.73 m2, and 23% had the APOL1 high–risk genotype (two copies of the high-risk allele). Over a mean follow-up of 7.8 years, 288 (42%) participants experienced CKD progression. As previously reported, the high-risk genotype was associated with higher risk of CKD progression compared with the low-risk genotype (hazard ratio [HR], 1.88; 95% confidence interval [95% CI], 1.46 to 2.41). Although we found some suggestion that obesity (HR, 1.48; 95% CI, 1.05 to 2.08 and HR, 2.44; 95% CI, 1.66 to 3.57 for body mass index ≥30 versus <30 kg/m2; P interaction =0.04) and increased urinary excretion of urea nitrogen (HR, 1.43; 95% CI, 0.98 to 2.09 versus HR, 2.33; 95% CI, 1.65 to 3.30 for urine urea nitrogen ≥8 versus <8 g/d; P interaction =0.04) were associated with lower APOL1–associated risk for CKD progression, these findings were not robust in sensitivity analyses with alternative cut points. No other sociodemographic (e.g., education and income), clinical (e.g., systolic BP and smoking), or laboratory (e.g., net endogenous acid production, urinary sodium and potassium excretions, 25-hydroxy vitamin D, intact parathyroid hormone, or fibroblast growth factor 23) variables modified the association between APOL1 and CKD progression (P interaction >0.05 for each). Conclusions Sociodemographic factors and common risk factors for CKD progression do not seem to alter APOL1–related CKD progression. Additional investigation is needed to identify nontraditional factors that may affect the association between APOL1 and progressive CKD. PMID:26430087

tir- and stx-Positive Escherichia coli in Stream Waters in a Metropolitan Area

PubMed Central

Higgins, James A.; Belt, Kenneth T.; Karns, Jeffrey S.; Russell-Anelli, Jonathan; Shelton, Daniel R.

2005-01-01

Diarrheagenic Escherichia coli, which may include the enteropathogenic E. coli and the enterohemorrhagic E. coli, are a significant cause of diarrheal disease among infants and children in both developing and developed areas. Disease outbreaks related to freshwater exposure have been documented, but the presence of these organisms in the urban aquatic environment is not well characterized. From April 2002 through April 2004 we conducted weekly surveys of streams in the metropolitan Baltimore, Md., area for the prevalence of potentially pathogenic E. coli by using PCR assays targeting the tir and stx1 and stx2 genes. Coliforms testing positive for the presence of the tir gene were cultured from 653 of 1,218 samples (53%), with a greater prevalence associated with urban, polluted streams than in suburban and forested watershed streams. Polluted urban streams were also more likely to test positive for the presence of one of the stx genes. Sequence analysis of the tir amplicon, as well as the entire tir gene from three isolates, indicated that the pathogenic E. coli present in the stream waters has a high degree of sequence homology with the E. coli O157:H7 serotype. Our data indicate that pathogenic E. coli are continually deposited into a variety of stream habitats and suggest that this organism may be a permanent member of the gastrointestinal microflora of humans and animals in the metropolitan Baltimore area. PMID:15870341

Study designs to investigate Nox1 acceleration of neoplastic progression in immortalized human epithelial cells by selection of differentiation resistant cells.

PubMed

Sattayakhom, Apsorn; Chunglok, Warangkana; Ittarat, Wanida; Chamulitrat, Walee

2014-01-01

To investigate the role of NADPH oxidase homolog Nox1 at an early step of cell transformation, we utilized human gingival mucosal keratinocytes immortalized by E6/E7 of human papillomavirus (HPV) type 16 (GM16) to generate progenitor cell lines either by chronic ethanol exposure or overexpression with Nox1. Among several cobblestone epithelial cell lines obtained, two distinctive spindle cell lines - FIB and NuB1 cells were more progressively transformed exhibiting tubulogenesis and anchorage-independent growth associated with increased invasiveness. These spindle cells acquired molecular markers of epithelial mesenchymal transition (EMT) including mesenchymal vimentin and simple cytokeratins (CK) 8 and 18 as well as myogenic alpha-smooth muscle actin and caldesmon. By overexpression and knockdown experiments, we showed that Nox1 on a post-translational level regulated the stability of CK18 in an ROS-, phosphorylation- and PKCepilon-dependent manner. PKCepilon may thus be used as a therapeutic target for EMT inhibition. Taken together, Nox1 accelerates neoplastic progression by regulating structural intermediate filaments leading to EMT of immortalized human gingival epithelial cells.

20 CFR 653.501 - Requirements for accepting and processing clearance orders.

Code of Federal Regulations, 2014 CFR

2014-04-01

...: (1) The job order does not contain an unlawful discriminatory specification by race, color, religion... time needed to return home for the beginning of the school year; (xi) An assurance that no extension of...

20 CFR 653.501 - Requirements for accepting and processing clearance orders.

Code of Federal Regulations, 2013 CFR

2013-04-01

...: (1) The job order does not contain an unlawful discriminatory specification by race, color, religion... time needed to return home for the beginning of the school year; (xi) An assurance that no extension of...

20 CFR 653.501 - Requirements for accepting and processing clearance orders.

Code of Federal Regulations, 2012 CFR

2012-04-01

...: (1) The job order does not contain an unlawful discriminatory specification by race, color, religion... time needed to return home for the beginning of the school year; (xi) An assurance that no extension of...

34 CFR 76.653 - Needs, number of students, and types of services.

Code of Federal Regulations, 2010 CFR

2010-07-01

... PROGRAMS What Conditions Must Be Met by the State and Its Subgrantees? Participation of Students Enrolled... determine the following matters on a basis comparable to that used by the subgrantee in providing for...

VizieR Online Data Catalog: Iron abundance of Terzan 5 stars (Massari+, 2014)

NASA Astrophysics Data System (ADS)

Massari, D.; Mucciarelli, A.; Ferraro, F. R.; Origlia, L.; Rich, R. M.; Lanzoni, B.; Dalessandro, E.; Valenti, E.; Ibata, R.; Lovisi, L.; Bellazzini, M.; Reitzel, D.

2017-05-01

This study is based on a sample of stars located within the tidal radius of Terzan 5 (rt~300''; Lanzoni et al. 2010ApJ...717..653L; Miocchi et al. 2013ApJ...774..151M) observed with two different instruments: FLAMES (Pasquini et al. 2002Msngr.110....1P) at the European Southern Observatory (ESO) VLT and DEIMOS (Faber et al. 2003SPIE.4841.1657F) at the Keck II Telescope. The spectroscopic targets have been selected from the optical photometric catalog of Terzan 5 described in Lanzoni et al. (2010ApJ...717..653L) along the brightest portion (I<17) of the red giant branch (RGB). In order to avoid contamination from other sources, we avoided stars with bright neighbors (Ineighbor

A Pedagogical Framework for the Use of Information and Communications Technology in Initial Teacher Training

ERIC Educational Resources Information Center

Hramiak, Alison

2006-01-01

This paper describes the initial findings of a longitudinal case study that investigates the use of e-learning and communications technology to enhance the placement experience for full-time post graduate certificate in education (PGCE) students. It is a work in progress examining how a VLE might be used to support trainees while they are on…

Airlock Battery Charge module

NASA Image and Video Library

2008-06-06

S124-E-006862 (6 June 2008) --- One of a series of digital still images documenting the Japanese Experiment Module, or JEM, also called Kibo, in its new home on the International Space Station, this view depicts Kibo's exterior in the distance, joined in the frame by some not so permanent hardware. The pictured components include the visiting Space Shuttle Discovery and a Russian Progress resupply vehicle.

Quench dynamics in strongly correlated Bose-Hubbard chains

NASA Astrophysics Data System (ADS)

Naegerl, Hanns-Christoph

2013-05-01

We present a series of experiments in the context of 1D physics with ultracold atoms, combining optical lattice potentials with the capability to tune the strength of the onsite particle interaction U. For an array of tilted 1D chains with site-to-site tilt E and initial unity occupation we record the dynamics after a quench to the phase transition point U ~E by monitoring the number of doublons created as a function of time after the quench. We observe characteristic oscillations from which we deduce a shift of the resonance condition as time progresses. For U/2 ~E and U/3 ~E we observe coupling to next-nearest neighbors and beyond.

The Muon g-2 Experiment overview and status as of June 2016

DOE PAGES

Holzbauer, J. L.

2016-12-09

The Muon g-2 Experiment at Fermilab will measure the anomalous magnetic moment of the muon to a precision of 140 parts per billion, which is a factor of four improvement over the previous E821 measurement at Brookhaven. The experiment will also extend the search for the electric dipole moment (EDM) of the muon by approximately two orders of magnitude, with a sensitivity down to 10 -21 e.cm. Both of these measurements are made by combining a precise measurement of the 1.45T storage ring magnetic field with an analysis of the modulation of the decay rate of higher-energy positrons (from anti-muons),more » recorded by 24 calorimeters and 3 straw tracking detectors. Furthermore, the recent progress in the alignment of the electrostatic quadrapole plates and the trolley rails inside the vacuum chambers, and in establishing the uniform storage ring magnetic field will be described.« less

Status of diamond particle detectors

NASA Astrophysics Data System (ADS)

Krammer, M.; Adam, W.; Bauer, C.; Berdermann, E.; Bogani, F.; Borchi, E.; Bruzzi, M.; Colledani, C.; Conway, J.; Dabrowski, W.; Delpierre, P.; Deneuville, A.; Dulinski, W.; van Eijk, B.; Fallou, A.; Fish, D.; Foulon, F.; Friedl, M.; Gan, K. K.; Gheeraert, E.; Grigoriev, E.; Hallewell, G.; Hall-Wilton, R.; Han, S.; Hartjes, F.; Hrubec, J.; Husson, D.; Kagan, H.; Kania, D.; Kaplon, J.; Kass, R.; Knöpfle, K. T.; Manfredi, P. F.; Meier, D.; Mishina, M.; LeNormand, F.; Pan, L. S.; Pernegger, H.; Pernicka, M.; Re, V.; Riester, G. L.; Roe, S.; Roff, D.; Rudge, A.; Schnetzer, S.; Sciortino, S.; Speziali, V.; Stelzer, H.; Stone, R.; Tapper, R. J.; Tesarek, R.; Thomson, G. B.; Trawick, M.; Trischuk, W.; Turchetta, R.; Walsh, A. M.; Wedenig, R.; Weilhammer, P.; Ziock, H.; Zoeller, M.

1998-11-01

To continue the exciting research in the field of particle physics new accelerators and experiments are under construction. In some of these experiments, e.g. ATLAS and CMS at the Large Hadron Collider at CERN or HERA-B at DESY, the detectors have to withstand an extreme environment. The detectors must be radiation hard, provide a very fast signal, and be as thin as possible. The properties of CVD diamond allow to fulfill these requirements and make it an ideal material for the detectors close to the interaction region of these experiments, i.e. the vertex detectors or the inner trackers. The RD42 collaboration is developing diamond detectors for these applications. The program of RD42 includes the improvement of the charge collection properties of CVD diamond, the study of the radiation hardness and the development of low-noise radiation hard readout electronics. An overview of the progress achieved during the last years will be given.

The Muon g-2 Experiment Overview and Status as of June 2016

NASA Astrophysics Data System (ADS)

Holzbauer, J.

2016-11-01

The Muon g-2 Experiment at Fermilab will measure the anomalous magnetic moment of the muon to a precision of 140 parts per billion, which is a factor of four improvement over the previous E821 measurement at Brookhaven. The experiment will also extend the search for the electric dipole moment (EDM) of the muon by approximately two orders of magnitude, with a sensitivity down to 10-21 e.cm. Both of these measurements are made by combining a precise measurement of the 1.45T storage ring magnetic field with an analysis of the modulation of the decay rate of higher-energy positrons (from anti-muons), recorded by 24 calorimeters and 3 straw tracking detectors. The recent progress in the alignment of the electrostatic quadrapole plates and the trolley rails inside the vacuum chambers, and in establishing the uniform storage ring magnetic field will be described.

Asynchronous Cooperative e-Learning System and Its Evaluation

NASA Astrophysics Data System (ADS)

Eto, Kazuhiro; Miyoshi, Takumi

Much attention has been attracted to collaborative learning on an e-learning system. However, it is difficult to implement the collaborative environment to an asynchronous e-learning system since collaboration would be realized only when learners join the system at the same time. On the other hand, cooperative learning has been proposed. In this method, learners can study on their own pace without making mutual agreement but with receiving cognitive information from others. In this paper, the authors have developed the asynchronous cooperative e-learning system that provides learners' attendance and studying progress as the cognitive information. The subjective evaluation experiments show that our system is slightly inferior to the synchronous collaborative e-learning system, but it can motivate the learners more than the conventional system.

Long-term outcome in BRAF(V600E) melanoma patients treated with vemurafenib: Patterns of disease progression and clinical management of limited progression.

PubMed

Puzanov, Igor; Amaravadi, Ravi K; McArthur, Grant A; Flaherty, Keith T; Chapman, Paul B; Sosman, Jeffrey A; Ribas, Antoni; Shackleton, Mark; Hwu, Patrick; Chmielowski, Bartosz; Nolop, Keith B; Lin, Paul S; Kim, Kevin B

2015-07-01

Vemurafenib induces tumour regression in most patients with BRAF(V600E)-mutant melanoma; eventually, most experience progressive disease (PD). Long-term follow-up of patients with BRAF(V600E) melanoma treated in the phase 1 vemurafenib trial is reported. Patients received vemurafenib 240-1120 mg (dose escalation cohort) or 960 mg (extension cohort) orally twice daily. Clinical response was evaluated every 8 weeks by Response Evaluation Criteria In Solid Tumors (RECIST). Patients with PD amenable to local therapy (surgery or radiotherapy) were allowed to continue vemurafenib after progression. Overall survival (OS) from time of treatment initiation and from PD was estimated. Sites of PD were recorded. Forty-eight patients (escalation cohort, n = 16; extension cohort, n = 32) received therapeutic doses of vemurafenib (⩾ 240 mg twice daily). Forty-four patients had PD by the time of this analysis and four remained progression free (follow-up time, 1.2-56.1 months). Median OS was 14 months (range, 1.2-56.1); 3- and 4-year melanoma-specific survival rate in the extension cohort was 26% and 19%, respectively. Median OS was 26.0 months (range, 7.7-56.1) among 20 patients who continued vemurafenib after local therapy. Median treatment duration beyond initial PD was 3.8 months (range, 1.1-26.6). In the extension cohort, six and five patients were alive after 3 and 4 years, respectively, on vemurafenib monotherapy. Some patients with melanoma achieved long-term survival with vemurafenib monotherapy. Continuation of vemurafenib after PD might be beneficial in some patients because remaining disease might continue to respond to BRAF inhibition. Copyright © 2015 Elsevier Ltd. All rights reserved.

FELIX: The new detector readout system for the ATLAS experiment

NASA Astrophysics Data System (ADS)

Ryu, Soo; ATLAS TDAQ Collaboration

2017-10-01

After the Phase-I upgrades (2019) of the ATLAS experiment, the Front-End Link eXchange (FELIX) system will be the interface between the data acquisition system and the detector front-end and trigger electronics. FELIX will function as a router between custom serial links and a commodity switch network using standard technologies (Ethernet or Infiniband) to communicate with commercial data collecting and processing components. The system architecture of FELIX will be described and the status of the firmware implementation and hardware development currently in progress will be presented.

Neutrino physics today, important issues and the future

DOE Office of Scientific and Technical Information (OSTI.GOV)

Parke, Stephen J.; /Fermilab

2010-10-01

The status and the most important issues in neutrino physics will be summarized as well as how the current, pressing questions will be addressed by future experiments. Since the discovery of neutrino flavor transitions by the SuperKamiokande experiment in 1998, which demonstrates that neutrinos change and hence their clocks tick, i.e. they are not traveling at the speed of light and hence are not massless, the field of neutrino physics has made remarkable progress in untangling the nature of the neutrino. However, there are still many important questions to answer.

Vitamin E δ-tocotrienol triggers endoplasmic reticulum stress-mediated apoptosis in human melanoma cells

PubMed Central

Montagnani Marelli, Marina; Marzagalli, Monica; Moretti, Roberta M.; Beretta, Giangiacomo; Casati, Lavinia; Comitato, Raffaella; Gravina, Giovanni L.; Festuccia, Claudio; Limonta, Patrizia

2016-01-01

Malignant melanoma is the leading cause of death from skin cancer. Drug toxicity and resistance represent a serious challange for melanoma treatments. Evidence demonstrates that natural compounds may play a crucial role in cancer prevention, growth and progression. Vitamin E tocotrienols (TT) were shown to possess antitumor activity. Here, we analyzed the effects of δ-TT on melanoma cell growth and the involvement of the endoplasmic reticulum (ER) stress in this activity. The experiments were performed on human melanoma cell lines, BLM and A375. δ-TT exerted a significant proapoptotic effect on both cell lines, involving the intrinsic apoptosis pathway; importantly, this compound did not affect the viability of normal human melanocytes. In melanoma cells, δ-TT exerted its antitumor effect through activation of the PERK/p-eIF2α/ATF4/CHOP, IRE1α and caspase-4 ER stress-related branches. Salubrinal, an inhibitor of the ER stress, counteracted the cytotoxic activity of δ-TT. In vivo experiments performed in nude mice bearing A375 xenografts evidenced that δ-TT reduces tumor volume and tumor mass; importantly, tumor progression was significantly delayed by δ-TT treatment. In conclusion, δ-TT exerts a proapoptotic activity on melanoma cells, through activation of the ER stress-related pathways. δ-TT might represent an effective option for novel chemopreventive/therapeutic strategies for melanoma. PMID:27461002

Free–free experiments: the search for dressed atom effects

NASA Astrophysics Data System (ADS)

Martin, N. L. S.; Weaver, C. M.; Kim, B. N.; deHarak, B. A.

2018-07-01

Experiments on free–free electron scattering, specifically the absorption or emission of 1.17 eV photons from a Nd:YAG laser field by an unbound electron when it is scattered by an atom or molecule, are reviewed. For large scattering angles such experiments are well described by a simple analytical theory that is independent of the properties of the target. At small scattering angles this theory breaks down for targets with a high dipole polarizability α, and an additional term needs to be incorporated in the scattering amplitude. This term is proportional to the dipole polarizability, and hence introduces the properties of the target into the free–free cross section—i.e., the laser field ‘dresses’ the atom. A progress report is given of free–free experiments designed to look for such ‘dressed atom’ effects during the electron-impact excitation of argon in the presence of a laser field; the lowest excited states of argon have α ≈ 300 atomic units.

Time-dependent progression from the acute to chronic phases in atopic dermatitis induced by epicutaneous allergen stimulation in NC/Nga mice.

PubMed

Kim, Ji-Yun; Jeong, Mi Sook; Park, Mi Kyung; Lee, Mi-Kyung; Seo, Seong Jun

2014-01-01

Atopic dermatitis (AD) is a complicated skin condition influenced by genetic background and environmental factors. In this study, we applied Dermatophagoides farinae body extract (DfE) to the barrier-disrupted skin of NC/Nga mice twice a week for 8 weeks to identify the clinical and immunological factors in AD progression. Repeated application of the DfE to the skin of NC/Nga mice showed the similar consequences for the natural course of progression in human AD, histologically and immunologically. We confirmed that the AD-like skin lesions in NC/Nga mice did not last for the whole period of our experiment in spite of repeated topical applications of DfE twice a week. Topical DfE stimulation increased the skin mRNA expressions of Th1-, Th2- and Th17-related cytokines in the acute phase. The expression patterns of IL-4 and IL-13 in splenic T cells and skin lesions were consistent with the time course alterations of clinical features of AD-like skin symptoms. We also showed that there was a remission phase either just before or right after the chronic phase in this experimental model. Interestingly, splenic T-cell-derived IL-5 expression began to increase in the chronic phase, while skin-derived IL-5 mRNA expression increased in the acute phase. In conclusion, our results suggest that we should pay attention to the characteristics of each stage of AD progression and choose a suitable corresponding stage of animal model not only to elucidate the pathogenesis of AD but also to develop and evaluate therapeutic drugs for AD. © 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

PASIS: A Distributed Framework for Perpetually Available and Secure Information Systems

DTIC Science & Technology

2005-07-01

6.5.3 Random over-requesting vs . intelligent server selection ......................... 76 6.5.4 Which server selection algorithm to use; which r value...of 16 KB blocks. .................................................................................. 98 Figure 8-4. Mean response time vs . Total

Oil Spill Prevention and Mitigation Improvement Act of 2010

THOMAS, 111th Congress

Sen. Brown, Scott P. [R-MA

2010-06-16

Senate - 06/24/2010 Committee on Energy and Natural Resources. Hearings held. Hearings printed: S.Hrg. 111-653, pt. 5. (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Stop Cozy Relationships with Big Oil Act of 2010

THOMAS, 111th Congress

Sen. Menendez, Robert [D-NJ

2010-05-26

Senate - 06/24/2010 Committee on Energy and Natural Resources. Hearings held. Hearings printed: S.Hrg. 111-653, pt. 5. (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

30 CFR 285.653 - What other reports or notices must I submit to MMS under my approved GAP?

Code of Federal Regulations, 2010 CFR

2010-07-01

..., DEPARTMENT OF THE INTERIOR OFFSHORE RENEWABLE ENERGY ALTERNATE USES OF EXISTING FACILITIES ON THE OUTER... effective, you must include your recommendations for new mitigation measures or monitoring methods. ...

42 CFR 456.653 - Acceptable reasons for not meeting requirements for annual on-site review.

Code of Federal Regulations, 2010 CFR

2010-10-01

... for Failure To Make a Satisfactory Showing of an Effective Institutional Utilization Control Program... will find an agency's showing satisfactory, even if it failed to meet the annual review requirements of...

Next Generation Muon g-2 Experiments

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hertzog, David W.

2015-12-02

I report on the progress of two new muon anomalous magnetic moment experiments, which are in advanced design and construction phases. The goal of Fermilab E989 is to reduce the experimental uncertainty ofmore » $$a_\\mu$$ from Brookhaven E821 by a factor of 4; that is, $$\\delta a_\\mu \\sim 16 \\times 10^{-11}$$, a relative uncertainty of 140~ppb. The method follows the same magic-momentum storage ring concept used at BNL, and pioneered previously at CERN, but muon beam preparation, storage ring internal hardware, field measuring equipment, and detector and electronics systems are all new or upgraded significantly. In contrast, J-PARC E34 will employ a novel approach based on injection of an ultra-cold, low-energy, muon beam injected into a small, but highly uniform magnet. Only a small magnetic focusing field is needed to maintain storage, which distinguishes it from CERN, BNL and Fermilab. E34 aims to roughly match the previous BNL precision in their Phase~1 installation.« less

Measuring the electron neutrino mass with improved sensitivity: the HOLMES experiment

NASA Astrophysics Data System (ADS)

Giachero, A.; Alpert, B. K.; Becker, D. T.; Bennett, D. A.; Biasotti, M.; Brofferio, C.; Ceriale, V.; Ceruti, G.; Corsini, D.; Day, P. K.; De Gerone, M.; Dressler, R.; Faverzani, M.; Ferri, E.; Fowler, J. W.; Fumagalli, E.; Gallucci, G.; Gard, J. D.; Gatti, F.; Hays-Wehle, J. P.; Heinitz, S.; Hilton, G. C.; Köster, U.; Lusignoli, M.; Mates, J. A. B.; Nisi, S.; Nucciotti, A.; Orlando, A.; Parodi, L.; Pessina, G.; Pizzigoni, G.; Puiu, A.; Ragazzi, S.; Reintsema, C. D.; Ribeiro Gomes, M.; Schmidt, D. R.; Schumann, D.; Siccardi, F.; Sisti, M.; Swetz, D. S.; Terranova, F.; Ullom, J. N.; Vale, L. R.

2017-02-01

HOLMES is a new experiment aiming at directly measuring the neutrino mass with a sensitivity below 2 eV . HOLMES will perform a calorimetric measurement of the energy released in the decay of 163Ho. The calorimetric measurement eliminates systematic uncertainties arising from the use of external beta sources, as in experiments with spectrometers. This measurement was proposed in 1982 by A. De Rujula and M. Lusignoli, but only recently the detector technological progress has allowed to design a sensitive experiment. HOLMES will deploy a 1000 pixels array of low temperature microcalorimeters with implanted 163Ho nuclei. HOLMES, besides being an important step forward in the direct neutrino mass measurement with a calorimetric approach, will also establish the potential of this approach to extend the sensitivity down to 0.1 eV and lower. The detectors used for the HOLMES experiment will be Mo/Cu bilayers TESs (Transition Edge Sensors) on SiNx membrane with gold absorbers. Microwave multiplexed rf-SQUIDs are the best available technique to read out large array of such detectors. An extensive R&D activity is in progress in order to maximize the multiplexing factor while preserving the performances of the individual detectors. To embed the 163Ho into the gold absorbers a custom mass separator ion implanter is being developed. The current activities are focused on the the single detector performances optimization and on the 163Ho isotope production and embedding. A preliminary measurement of a sub-array of 4× 16 detectors is planned late in 2017. In this contribution we present the HOLMES project with its technical challenges, its status and perspectives.

Final Report: Levitated Dipole Experiment

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kesner, Jay; Mauel, Michael

2013-03-10

Since the very first experiments with the LDX, research progress was rapid and significant. Initial experiments were conducted with the high-field superconducting coil suspended by three thin rods. These experiments produced long-pulse, quasi-steady-state microwave discharges, lasting more than 10 s, having peak beta values of 20% [Garnier et al., Physics of Plasmas, 13 (2006) 056111]. High- beta, near steady-state discharges have been maintained in LDX for more than 20 seconds, and this capability made LDX the longest pulse fusion confinement experiment operating in the U.S. fusion program. A significant measure of progress in the LDX research program was the routinemore » investigation of plasma confinement with a magnetically-levitated dipole and the resulting observations of confinement improvement. In both supported and levitated configurations, detailed measurements were made of discharge evolution, plasma dynamics and instability, and the roles of gas fueling, microwave power deposition profiles, and plasma boundary shape. High-temperature plasma was created by multi frequency electron cyclotron resonance heating at 2.45 GHz, 6.4 GHz, 10.5 GHz and 28 GHz allowing control of heating profiles. Depending upon neutral fueling rates, the LDX discharges contain a fraction of energetic electrons, with mean energies above 50 keV. Depending on whether or not the superconducting dipole was levitated or supported, the peak thermal electron temperature was estimated to exceed 500 eV and peak densities to approach 1e18 m -3. We have found that levitation causes a strong inwards density pinch [Boxer et al., Nature Physics, 6 (2010) 207] and we have observed the central plasma density increase dramatically indicating a significant improvement in the confinement of a thermal plasma species.« less

Authorization for the Use of Military Force against the Islamic State of Iraq and the Levant

THOMAS, 113th Congress

Sen. Menendez, Robert [D-NJ

2014-12-13

Senate - 12/13/2014 Placed on Senate Legislative Calendar under General Orders. Calendar No. 653. (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Thermophysical Modeling of Novel Machinable Ceramic Materials

DTIC Science & Technology

2009-11-01

ORGANIZATION REPORT NUMBER Gonzalo Gutierrez. Departamento de Fisica , Facultad de Ciencias. L’niversidad de Chile. Casilla 653, Santiago, Chile...Walter Orellana, Departamento de Fisica , Universidad Andres Belio, Chile www.gnm.cl 9. SPONSORING / MONITORING AGENCY NAME(S) AND ADDRESS(ES

40 CFR 721.10619 - Perfluoroalkylethyl methacrylate copolymer (generic).

Code of Federal Regulations, 2014 CFR

2014-07-01

... as perfluoroalkylethyl methacrylate copolymer (PMN P-11-653) is subject to reporting under this... 40 Protection of Environment 31 2014-07-01 2014-07-01 false Perfluoroalkylethyl methacrylate... Specific Chemical Substances § 721.10619 Perfluoroalkylethyl methacrylate copolymer (generic). (a) Chemical...

40 CFR 721.10619 - Perfluoroalkylethyl methacrylate copolymer (generic).

Code of Federal Regulations, 2013 CFR

2013-07-01

... as perfluoroalkylethyl methacrylate copolymer (PMN P-11-653) is subject to reporting under this... 40 Protection of Environment 32 2013-07-01 2013-07-01 false Perfluoroalkylethyl methacrylate... Specific Chemical Substances § 721.10619 Perfluoroalkylethyl methacrylate copolymer (generic). (a) Chemical...

Management of non-progressive dysarthria: practice patterns of speech and language therapists in the Republic of Ireland.

PubMed

Conway, Aifric; Walshe, Margaret

2015-01-01

Dysarthria is a commonly acquired speech disorder. Rising numbers of people surviving stroke and traumatic brain injury (TBI) mean the numbers of people with non-progressive dysarthria are likely to increase, with increased challenges for speech and language therapists (SLTs), service providers and key stakeholders. The evidence base for assessment and intervention approaches with this population remains limited with clinical guidelines relying largely on clinical experience, expert opinion and limited research. Furthermore, there is currently little evidence on the practice behaviours of SLTs available. To investigate whether SLTs in the Republic of Ireland (ROI) vary in how they assess and manage adults with non-progressive dysarthria; to explore SLTs' use of the theoretical principles that influence therapeutic approaches; to identify challenges perceived by SLTs when working with adults with non-progressive dysarthria; and to determine SLTs' perceptions of further training needs. A 33-item survey questionnaire was devised and disseminated electronically via SurveyMonkey to SLTs working with non-progressive dysarthria in the ROI. SLTs were identified through e-mail lists for special-interest groups, SLT manager groups and general SLT mailing lists. A reminder e-mail was sent to all SLTs 3 weeks later following the initial e-mail containing the survey link. The survey remained open for 6 weeks. Questionnaire responses were analysed using descriptive statistics. Qualitative comments to open-ended questions were analysed through thematic analysis. Eighty SLTs responded to the survey. Sixty-seven of these completed the survey in full. SLTs provided both quantitative and qualitative data regarding their assessment and management practices in this area. Practice varied depending on the context of the SLT service, experience of SLTs and the resources available to them. Not all SLTs used principles such as motor programming or neural plasticity to direct clinical work and some requested further direction in this area. SLTs perceived that the key challenges associated with working in this area were the compliance, insight and motivation of adults with dysarthria. The use of specific treatment programmes varies amongst SLTs. A lack of resources is reported to restrict practice in both assessment and management. Ongoing research into the effectiveness of SLT interventions with adults with non-progressive dysarthria is required to guide clinical decision-making. SLTs identified further training needs which may provide direction for the development of professional training courses in the future. © 2015 Royal College of Speech and Language Therapists.

HOLMES: The electron capture decay of [Formula: see text]Ho to measure the electron neutrino mass with sub-eV sensitivity.

PubMed

Alpert, B; Balata, M; Bennett, D; Biasotti, M; Boragno, C; Brofferio, C; Ceriale, V; Corsini, D; Day, P K; De Gerone, M; Dressler, R; Faverzani, M; Ferri, E; Fowler, J; Gatti, F; Giachero, A; Hays-Wehle, J; Heinitz, S; Hilton, G; Köster, U; Lusignoli, M; Maino, M; Mates, J; Nisi, S; Nizzolo, R; Nucciotti, A; Pessina, G; Pizzigoni, G; Puiu, A; Ragazzi, S; Reintsema, C; Gomes, M Ribeiro; Schmidt, D; Schumann, D; Sisti, M; Swetz, D; Terranova, F; Ullom, J

The European Research Council has recently funded HOLMES, a new experiment to directly measure the neutrino mass. HOLMES will perform a calorimetric measurement of the energy released in the decay of [Formula: see text]Ho. The calorimetric measurement eliminates systematic uncertainties arising from the use of external beta sources, as in experiments with beta spectrometers. This measurement was proposed in 1982 by A. De Rujula and M. Lusignoli, but only recently the detector technological progress allowed to design a sensitive experiment. HOLMES will deploy a large array of low temperature microcalorimeters with implanted [Formula: see text]Ho nuclei. The resulting mass sensitivity will be as low as 0.4 eV. HOLMES will be an important step forward in the direct neutrino mass measurement with a calorimetric approach as an alternative to spectrometry. It will also establish the potential of this approach to extend the sensitivity down to 0.1 eV. We outline here the project with its technical challenges and perspectives.

Recent progress on the Axion Dark Matter eXperiment (ADMX)

NASA Astrophysics Data System (ADS)

Khatiwada, Rakshya; ADMX Collaboration

2017-01-01

The Axion Dark Matter eXperiment (ADMX) is one of the three ``Generation-2'' direct dark matter searches and the only one dedicated to finding the axion. It looks for axions that convert into photons through the Primakoff process in the presence of a strong magnetic field. The mass of the axion is unknown but expected to be few to tens of μeV, which corresponds to photons in the GHz range. The expected signal power is of the order 10-24 W, which puts stringent requirements on the system's noise level. ADMX has recently started its Generation-2 data run with the recent upgrades of a dilution refrigerator, which cools the system to sub-K temperature suppressing the thermal background noise and tunable, near quantum noise-limited SQUID amplifiers. This talk will summarize the current status and operation of ADMX experiment as it searches for dark matter axions. Supported by DOE Grants DE-SC0010280, DE-FG02-96ER40956, DE-AC52-07NA27344, DE-AC03-76SF00098, the Heising-Simons Foundation and the LLNL, FNAL and PNNL LDRD program.

What do short-term and long-term relationships look like? Building the relationship coordination and strategic timing (ReCAST) model.

PubMed

Eastwick, Paul W; Keneski, Elizabeth; Morgan, Taylor A; McDonald, Meagan A; Huang, Sabrina A

2018-05-01

Close relationships research has examined committed couples (e.g., dating relationships, marriages) using intensive methods that plot relationship development over time. But a substantial proportion of people's real-life sexual experiences take place (a) before committed relationships become "official" and (b) in short-term relationships; methods that document the time course of relationships have rarely been applied to these contexts. We adapted a classic relationship trajectory-plotting technique to generate the first empirical comparisons between the features of people's real-life short-term and long-term relationships across their entire timespan. Five studies compared long-term and short-term relationships in terms of the timing of relationship milestones (e.g., flirting, first sexual intercourse) and the occurrence/intensity of important relationship experiences (e.g., romantic interest, strong sexual desire, attachment). As romantic interest was rising and partners were becoming acquainted, long-term and short-term relationships were indistinguishable. Eventually, romantic interest in short-term relationships plateaued and declined while romantic interest in long-term relationships continued to rise, ultimately reaching a higher peak. As relationships progressed, participants evidenced more features characteristic of the attachment-behavioral system (e.g., attachment, caregiving) in long-term than short-term relationships but similar levels of other features (e.g., sexual desire, self-promotion, intrasexual competition). These data inform a new synthesis of close relationships and evolutionary psychological perspectives called the Relationship Coordination and Strategic Timing (ReCAST) model. ReCAST depicts short-term and long-term relationships as partially overlapping trajectories (rather than relationships initiated with distinct strategies) that differ in their progression along a normative relationship development sequence. (PsycINFO Database Record (c) 2018 APA, all rights reserved).

Enabling High Efficiency Ethanol Engines

DOE Office of Scientific and Technical Information (OSTI.GOV)

Szybist, J.; Confer, K.

2011-03-01

Delphi Automotive Systems and ORNL established this CRADA to explore the potential to improve the energy efficiency of spark-ignited engines operating on ethanol-gasoline blends. By taking advantage of the fuel properties of ethanol, such as high compression ratio and high latent heat of vaporization, it is possible to increase efficiency with ethanol blends. Increasing the efficiency with ethanol-containing blends aims to remove a market barrier of reduced fuel economy with E85 fuel blends, which is currently about 30% lower than with petroleum-derived gasoline. The same or higher engine efficiency is achieved with E85, and the reduction in fuel economy ismore » due to the lower energy density of E85. By making ethanol-blends more efficient, the fuel economy gap between gasoline and E85 can be reduced. In the partnership between Delphi and ORNL, each organization brought a unique and complementary set of skills to the project. Delphi has extensive knowledge and experience in powertrain components and subsystems as well as overcoming real-world implementation barriers. ORNL has extensive knowledge and expertise in non-traditional fuels and improving engine system efficiency for the next generation of internal combustion engines. Partnering to combine these knowledge bases was essential towards making progress to reducing the fuel economy gap between gasoline and E85. ORNL and Delphi maintained strong collaboration throughout the project. Meetings were held regularly, usually on a bi-weekly basis, with additional reports, presentations, and meetings as necessary to maintain progress. Delphi provided substantial hardware support to the project by providing components for the single-cylinder engine experiments, engineering support for hardware modifications, guidance for operational strategies on engine research, and hardware support by providing a flexible multi-cylinder engine to be used for optimizing engine efficiency with ethanol-containing fuels.« less

Walter Benjamin Confidente de Adorno e Horkheimer na Dialetica do Esclarecimento (Walter Benjamin, Confidant of Adorno and Horkheimer in the Dialectic of the Enlightenment).

ERIC Educational Resources Information Center

Pucci, Bruno

2000-01-01

Explains that Benjamin, Adorno, and Horkheimer developed philosophical and aesthetic experiences concerning topics of the moment based on similar presuppositions and ideas. Approaches two areas within the confidentiality shared by the interliniation of the Dialectic of the Enlightenment: critique of history as progress and education of the senses.…

Study of quantum correlation swapping with relative entropy methods

NASA Astrophysics Data System (ADS)

Xie, Chuanmei; Liu, Yimin; Chen, Jianlan; Zhang, Zhanjun

2016-02-01

To generate long-distance shared quantum correlations (QCs) for information processing in future quantum networks, recently we proposed the concept of QC repeater and its kernel technique named QC swapping. Besides, we extensively studied the QC swapping between two simple QC resources (i.e., a pair of Werner states) with four different methods to quantify QCs (Xie et al. in Quantum Inf Process 14:653-679, 2015). In this paper, we continue to treat the same issue by employing other three different methods associated with relative entropies, i.e., the MPSVW method (Modi et al. in Phys Rev Lett 104:080501, 2010), the Zhang method (arXiv:1011.4333 [quant-ph]) and the RS method (Rulli and Sarandy in Phys Rev A 84:042109, 2011). We first derive analytic expressions of all QCs which occur during the swapping process and then reveal their properties about monotonicity and threshold. Importantly, we find that a long-distance shared QC can be generated from two short-distance ones via QC swapping indeed. In addition, we simply compare our present results with our previous ones.

Tunable Photonic Band Gap of PS-b-P2VP Lamellar Film Using Metal Ions and pH Gradation.

PubMed

Baek, Young-Bin; Choi, Soo-Hyung; Shin, Dong-Myung

2015-02-01

Optical properties of photonic crystal film were investigated by tuning photonic band gap (PBG). The lamellar-forming photonic films were prepared by nearly symmetric poly(styrene-b-2-vinyl pyridine) (PS-b-P2VP) block copolymers. Molecular weight of PS block and P2VP block is 52 kg/mol, and 57 kg/mol, respectively. When submerged in water, the lamellar films were swollen and show Bragg reflection in visible light region. We observed that the reflection color can be tuned by ion concentration (e.g., hydrogen or metal ion) in water. The higher concentration of hydrogen ion in solution, the longer reflectance wavelength shifted (from 537 nm to 743 nm). In addition, max-reflectance wavelength is dependent on both metal ion and the concentration. The max-reflectance wavelength is shifted from 653 nm (i.e., in water without ion) to 430 nm, 465 nm, and 505 nm for 120 mM of Ca2+, Fe2+, and Cu2+, respectively. Therefore, we can control the photonic band gap of photonic devices by changing the condition of swelling solution.

The polysaccharides from fermented Ganoderma lucidum mycelia induced miRNAs regulation in suppressed HepG2 cells.

PubMed

Shen, Jie; Park, Hyeon-soo; Xia, Yong-mei; Kim, Gon-sup; Cui, Steve W

2014-03-15

Medicinal mushroom polysaccharides such as Ganoderma lucidum polysaccharides (GLPs) have been commonly hypothesized to suppress tumor cells proliferation through immune effects. To verify this hypothesis through investigating comprehensive miRNA expression in polysaccharide treated cancer cells, an anticancer mycelia GLP was employed to disclose miRNA differential expression of human hepatocarcinoma cells (HepG2), by using a miRNA microarray assay based on Sanger miR-Base Release 16. The experiment and the analysis result indicates that among the 61 differential expressed miRNAs (p ≤ 0.01), 17 of them were regulated significantly. GLP can inhibit HepG2 cells directly through regulation of hepatocarcinoma genes. A newly found miR-3131 exhibited the strongest upregulation (92-folds, Log2 = 6.53, p = 0.000016). The miRNAs responded synergistically in both hepatocarcinoma and immune-related aspects. Copyright © 2014 Elsevier Ltd. All rights reserved.

Reading from Scratch - A Vision-System for Reading Data on Micro-structured Surfaces

NASA Astrophysics Data System (ADS)

Dragon, Ralf; Becker, Christian; Rosenhahn, Bodo; Ostermann, Jörn

Labeling and marking industrial manufactured objects gets increasingly important nowadays because of novel material properties and plagiarism. As part of the Collaborative Research Center 653 which investigates micro-structured metallic surfaces for inherent mechanical data storage, we research into a stable and reliable optical readout of the written data. Since this comprises a qualitative surface reconstruction, we use directed illumination to make the micro structures visible. Then we apply a spectral analysis to obtain image partitioning and perform signal tracking enhanced by a customized Hidden Markov Model. In this paper, we derive the algorithms used and demonstrate reading data from a surface with 1.6kbit/cm2 from a micro-structured groove which varies by only 3μ m in depth (thus a “scratch”). We demonstrate the system’s robustness with experiments with real and artificially-rendered surfaces.

Use of Electronic Documentation for Quality Improvement in Hospice

PubMed Central

Cagle, John G.; Rokoske, Franziska S.; Durham, Danielle; Schenck, Anna P.; Spence, Carol; Hanson, Laura C.

2015-01-01

Little evidence exists on the use of electronic documentation in hospice and its relationship to quality improvement practices. The purposes of this study were to: (1) estimate the prevalence of electronic documentation use in hospice; (2) identify organizational characteristics associated with use of electronic documentation; and (3) determine whether quality measurement practices differed based on documentation format (electronic vs. nonelectronic). Surveys concerning the use of electronic documentation for quality improvement practices and the monitoring of quality-related care and outcomes were collected from 653 hospices. Users of electronic documentation were able to monitor a wider range of quality-related data than users of nonelectronic documentation. Quality components such as advanced care planning, cultural needs, experience during care of the actively dying, and the number/types of care being delivered were more likely to be documented by users of electronic documentation. Use of electronic documentation may help hospices to monitor quality and compliance. PMID:22267819

47 CFR 74.789 - Broadcast regulations applicable to digital low power television and television translator stations.

Code of Federal Regulations, 2011 CFR

2011-10-01

... AND OTHER PROGRAM DISTRIBUTIONAL SERVICES Low Power TV, TV Translator, and TV Booster Stations § 74... applicable to translators, low power, and booster stations (except § 73.653—Operation of TV aural and visual...

47 CFR 74.789 - Broadcast regulations applicable to digital low power television and television translator stations.

Code of Federal Regulations, 2013 CFR

2013-10-01

... AND OTHER PROGRAM DISTRIBUTIONAL SERVICES Low Power TV, TV Translator, and TV Booster Stations § 74... applicable to translators, low power, and booster stations (except § 73.653—Operation of TV aural and visual...

47 CFR 74.789 - Broadcast regulations applicable to digital low power television and television translator stations.

Code of Federal Regulations, 2014 CFR

2014-10-01

... AND OTHER PROGRAM DISTRIBUTIONAL SERVICES Low Power TV, TV Translator, and TV Booster Stations § 74... applicable to translators, low power, and booster stations (except § 73.653—Operation of TV aural and visual...

47 CFR 74.789 - Broadcast regulations applicable to digital low power television and television translator stations.

Code of Federal Regulations, 2012 CFR

2012-10-01

... AND OTHER PROGRAM DISTRIBUTIONAL SERVICES Low Power TV, TV Translator, and TV Booster Stations § 74... applicable to translators, low power, and booster stations (except § 73.653—Operation of TV aural and visual...

Recent progress in understanding electron thermal transport in NSTX

DOE PAGES

Ren, Y.; Belova, E.; Gorelenkov, N.; ...

2017-03-10

The anomalous level of electron thermal transport inferred in magnetically confined configurations is one of the most challenging problems for the ultimate realization of fusion power using toroidal devices: tokamaks, spherical tori and stellarators. It is generally believed that plasma instabilities driven by the abundant free energy in fusion plasmas are responsible for the electron thermal transport. The National Spherical Torus eXperiment (NSTX) (Ono et al 2000 Nucl. Fusion 40 557) provides a unique laboratory for studying plasma instabilities and their relation to electron thermal transport due to its low toroidal field, high plasma beta, low aspect ratio and largemore » ExB flow shear. Recent findings on NSTX have shown that multiple instabilities are required to explain observed electron thermal transport, given the wide range of equilibrium parameters due to different operational scenarios and radial regions in fusion plasmas. Here we review the recent progresses in understanding anomalous electron thermal transport in NSTX and focus on mechanisms that could drive electron thermal transport in the core region. The synergy between experiment and theoretical/ numerical modeling is essential to achieving these progresses. The plans for newly commissioned NSTX-Upgrade will also be discussed.« less

Selection of the distributional rule as an alternative tool to foster cooperation in a Public Good Game

NASA Astrophysics Data System (ADS)

Colasante, Annarita

2017-02-01

This paper presents an investigation about cooperation in a Public Good Game using an Agent Based Model calibrated on experimental data. Starting from the experiment proposed in Colasante and Russo (2016), we analyze the dynamic of cooperation in a Public Good Game where agents receive an heterogeneous income and choose both the level of contribution and the distribution rule. The starting point is the calibration and the output validation of the model using the experimental results. Once tested the goodness of fit of the Agent Based Model, we run some policy experiment in order to verify how each distribution rule, i.e. equidistribution, proportional to contribution and progressive, affects the level of contribution in the simulated model. We find out that the share of cooperators decreases over time if we exogenously set the equidistribution rule. On the contrary, the share of cooperators converges to 100 % if we impose the progressive rule. Finally, the most interesting result refers to the effect of the progressive rule. We observe that, in the case of high inequality, this rule is not able to reduce the heterogeneity of income.

Impact of visual inspection with acetic acid plus cryotherapy "see and treat" approach on the reduction of the population burden of cervical preinvasive lesions in Southeast Nigeria.

PubMed

Chigbu, C O; Onyebuchi, A K; Nnakenyi, E F; Egbuji, C C

2017-02-01

The aim of this study is to determine the impact of visual inspection with acetic acid (VIA) plus immediate cryotherapy on the prevalence of VIA-detected cervical squamous intraepithelial lesion (SIL). Women in four rural communities in Southeast Nigeria were screened with VIA. Women who tested positive to VIA were offered either immediate cryotherapy or large loop excision of the transformation zone based on predetermined eligibility criteria. Cervical biopsies were taken before cryotherapy and examined by consultant histopathologists. All participants were rescreened 1 year later. The main outcome measures were population prevalence of cervical precancers before and after intervention, cure rates, and over-treatment rates. A total of 653 women participated in the study. The prevalence of cervical SIL before the intervention was 8.9% (58/653). The prevalence 1 year later was 1.4% (9/649). This gave an 84.3% reduction in the population prevalence of SIL. The reduction in cervical SIL prevalence was statistically significant (P = 0.0001). The prevalence of high-grade SIL reduced significantly from 4.1% (27/653) preintervention to 0.5% (3/649) 1 year postintervention (P = 0.0001). This gave an 87.8% reduction in the population prevalence of high-grade SIL. Cryotherapy provided a cure rate of 87.9% (95% confidence interval: 76.82-94.33). Population cervical cancer prevention using VIA plus immediate cryotherapy leads to significant reduction in the population prevalence of cervical SIL. This has the potential of being an acceptable supplement to cervical cytology for cervical cancer prevention in low-income populations.

Recent Demographic Developments in France: Relatively Low Mortality at Advanced Ages.

PubMed

Prioux, France; Barbieri, Magali

2012-10-01

France had 65.3 million inhabitants as of 1 January 2012, including 1.9 million in the overseas départements . The population is slightly younger than that of the European Union as a whole. Population growth continues at the same rate, mainly through natural increase. There are now more African than European immigrants living in France. Fertility was practically stable in 2011 (2.01 children per woman), but the lifetime fertility of the 1971-1972 cohorts reached a historic low in metropolitan France (1.99 children per woman), nevertheless remaining among the highest in Europe. Abortion levels remained stable and rates among young people are no longer increasing. The marriage rate is falling and the divorce rate has stabilized (46.2 divorces per 100 marriages in 2011). The risk of divorce decreases with age, but has greatly increased among the under-70s over the last decade. Life expectancy at birth (78.4 years for men, 85.0 for women) has continued to increase at the same rate, mainly thanks to progress at advanced ages. Among European countries, France has the lowest mortality in the over-65 age group, but it ranks less well for premature mortality.

Recent Demographic Developments in France: Relatively Low Mortality at Advanced Ages

PubMed Central

Prioux, France; Barbieri, Magali

2013-01-01

France had 65.3 million inhabitants as of 1 January 2012, including 1.9 million in the overseas départements. The population is slightly younger than that of the European Union as a whole. Population growth continues at the same rate, mainly through natural increase. There are now more African than European immigrants living in France. Fertility was practically stable in 2011 (2.01 children per woman), but the lifetime fertility of the 1971–1972 cohorts reached a historic low in metropolitan France (1.99 children per woman), nevertheless remaining among the highest in Europe. Abortion levels remained stable and rates among young people are no longer increasing. The marriage rate is falling and the divorce rate has stabilized (46.2 divorces per 100 marriages in 2011). The risk of divorce decreases with age, but has greatly increased among the under-70s over the last decade. Life expectancy at birth (78.4 years for men, 85.0 for women) has continued to increase at the same rate, mainly thanks to progress at advanced ages. Among European countries, France has the lowest mortality in the over-65 age group, but it ranks less well for premature mortality. PMID:24285939

[Factors related to purchasing over-the-counter medications online].

PubMed

Kishimoto, Keiko; Yoshida, Takeshi; Fukushima, Noriko

2009-09-01

We conducted a Web-based survey of approximately 40,000 Internet users on the purchase of over-the-counter (OTC) medications online in March 2009. The valid response rate was 97.8% and the number of responses was 39,208. The number of people who had purchased OTC medications online was 4,653 (11.9%), prescription medicines 792 (2.0%), and medical contact lenses 1,993 (5.1%). As a result of the multiple logistic regression analysis, independent variables with odds ratios (ORs) >1.5 were experience of purchasing prescription-only medicine online (OR=4.997, 95%CI=4.288-5.824), regular supplement use (OR=2.384, 95%CI=2.233-2.548), experience of purchasing colored contact lenses online (OR=2.206, 95%CI=1.632-2.983), no time to visit drugstores (OR=2.092, 95%CI=1.928-2.270), usage of Web sites of uncertain reliability (OR=1.992, 95%CI=1.857-2.137), and experience of purchasing therapeutic contact lenses online (OR=1.796, 95%CI=1.597-2.020). As some people have purchased prescription-only medicine or medical devices and had problems with drug information sources, the development of awareness of medical and pharmaceutical supplies and health and medical information literacy are key priorities to ensure safe OTC medication sales systems.

Effect of sucrose and safflower oil preloads on short term appetite and food intake of young men.

PubMed

Woodend, D M; Anderson, G H

2001-12-01

The effects of carbohydrate and fat on satiety have been examined primarily through meal composition studies. The purpose of this study was to compare the effects of pure sucrose and safflower oil, isovolumetric beverage preloads, on appetite (measured every 15 minutes by visual analogue scales) and food intake 60 minutes later. Young men consumed 0, 418, 836 and 1254 kJ of sucrose in the first two experiments and these same doses of safflower oil in the third. Finally, the largest doses of sucrose and safflower oil were compared. Sucrose, but not safflower oil, suppressed average appetite compared with control. In experiment 2, food intake was reduced (p<0.05) by 518 kJ after the 418 and 836 kJ preloads and by 1129 kJ after the 1254 kJ sucrose preload. Only the 1254 kJ dose of safflower oil significantly suppressed food intake by 480 kJ in the third experiment. When the 1254 kJ doses were compared directly, sucrose suppressed food intake by 653 kJ compared with control where as safflower oil did not. It is concluded that, in the short-term, sucrose produces a dose dependent reduction in appetite and food intake that is greater than that produced by safflower oil.

In situ Raman and X-ray diffraction studies on the high pressure and temperature stability of methane hydrate up to 55 GPa.

PubMed

Kadobayashi, Hirokazu; Hirai, Hisako; Ohfuji, Hiroaki; Ohtake, Michika; Yamamoto, Yoshitaka

2018-04-28

High-temperature and high-pressure experiments were performed under 2-55 GPa and 298-653 K using in situ Raman spectroscopy and X-ray diffraction combined with externally heated diamond anvil cells to investigate the stability of methane hydrate. Prior to in situ experiments, the typical C-H vibration modes of methane hydrate and their pressure dependence were measured at room temperature using Raman spectroscopy to make a clear discrimination between methane hydrate and solid methane which forms through the decomposition of methane hydrate at high temperature. The sequential in situ Raman spectroscopy and X-ray diffraction revealed that methane hydrate survives up to 633 K and 40.3 GPa and then decomposes into solid methane and ice VII above the conditions. The decomposition curve of methane hydrate estimated by the present experiments is >200 K lower than the melting curves of solid methane and ice VII, and moderately increases with increasing pressure. Our result suggests that although methane hydrate may be an important candidate for major constituents of cool exoplanets and other icy bodies, it is unlikely to be present in the ice mantle of Neptune and Uranus, where the temperature is expected to be far beyond the decomposition temperatures.

In situ Raman and X-ray diffraction studies on the high pressure and temperature stability of methane hydrate up to 55 GPa

NASA Astrophysics Data System (ADS)

Kadobayashi, Hirokazu; Hirai, Hisako; Ohfuji, Hiroaki; Ohtake, Michika; Yamamoto, Yoshitaka

2018-04-01

High-temperature and high-pressure experiments were performed under 2-55 GPa and 298-653 K using in situ Raman spectroscopy and X-ray diffraction combined with externally heated diamond anvil cells to investigate the stability of methane hydrate. Prior to in situ experiments, the typical C-H vibration modes of methane hydrate and their pressure dependence were measured at room temperature using Raman spectroscopy to make a clear discrimination between methane hydrate and solid methane which forms through the decomposition of methane hydrate at high temperature. The sequential in situ Raman spectroscopy and X-ray diffraction revealed that methane hydrate survives up to 633 K and 40.3 GPa and then decomposes into solid methane and ice VII above the conditions. The decomposition curve of methane hydrate estimated by the present experiments is >200 K lower than the melting curves of solid methane and ice VII, and moderately increases with increasing pressure. Our result suggests that although methane hydrate may be an important candidate for major constituents of cool exoplanets and other icy bodies, it is unlikely to be present in the ice mantle of Neptune and Uranus, where the temperature is expected to be far beyond the decomposition temperatures.

Providing Real Research Opoportunities to Undergraduates

NASA Astrophysics Data System (ADS)

Ragozzine, Darin

2016-01-01

The current approach to undergraduate education focuses on teaching classes which provide the foundational knowledge for more applied experiences such as scientific research. Like most programs, Florida Institute of Technology (Florida Tech or FIT) strongly encourages undergraduate research, but is dominated by content-focused courses (e.g., "Physical Mechanics"). Research-like experiences are generally offered through "lab" classes, but these are almost always reproductions of past experiments: contrived, formulaic, and lacking the "heart" of real (i.e., potentially publishable) scientific research. Real research opportunities 1) provide students with realistic insight into the actual scientific process; 2) excite students far more than end-of-chapter problems; 3) provide context for the importance of learning math, physics, and astrophysics concepts; and 4) allow unique research progress for well-chosen problems. I have provided real research opportunities as an "Exoplanet Lab" component of my Introduction to Space Science (SPS1020) class at Florida Tech, generally taken by first-year majors in our Physics, Astronomy & Astrophysics, Planetary Science, and Astrobiology degree programs. These labs are a hybrid between citizen science (e.g., PlanetHunters) and simultaneously mentoring ~60 undergraduates in similar small research projects. These projects focus on problems that can be understood in the context of the course, but which benefit from "crowdsourcing". Examples include: dividing up the known planetary systems and developing a classification scheme and organizing them into populations (Fall 2013); searching through folded light curves to discover new exoplanets missed by previous pipelines (Fall 2014); and fitting n-body models to all exoplanets with known Transit Timing Variations to estimate planet masses (Fall 2015). The students love the fact that they are doing real potentially publishable research: not many undergraduates can claim to have discovered new exoplanets! Based on these experiences, I will present practical insights into successfully organizing real research opportunities. By employing some of these best practices, we can truly educate students and make scientific progress.

Feeling bad about progress does not lead people want to change their health behaviour.

PubMed

Reynolds, James P; Webb, Thomas L; Benn, Yael; Chang, Betty P I; Sheeran, Paschal

2018-02-01

When do people decide to do something about problematic health behaviours? Theoretical models and pragmatic considerations suggest that people should take action when they feel bad about their progress - in other words, when they experience negative progress-related affect. However, the impact of progress-related affect on goal striving has rarely been investigated. Study 1 (N = 744) adopted a cross-sectional design and examined the extent to which measures of progress-related affect were correlated with intentions to take action. Study 2 (N = 409) investigated the impact of manipulating progress-related affect on intentions and behaviour in an experimental design. Study 1 found that, while engaging in health behaviours had the expected affective consequences (e.g. people felt bad when they were not eating healthily, exercising regularly or limiting their alcohol consumption), it was feeling good rather than bad about progress that was associated with stronger intentions. Study 2 replicated these findings. Participants induced to feel good about their eating behaviour had marginally stronger intentions to eat healthily than participants led to feel bad about their eating behaviour. The findings have implications for interventions designed to promote changes in health behaviour, as well as theoretical frameworks for understanding self-regulation.

A focal plane metrology system and PSF centroiding experiment

NASA Astrophysics Data System (ADS)

Li, Haitao; Li, Baoquan; Cao, Yang; Li, Ligang

2016-10-01

In this paper, we present an overview of a detector array equipment metrology testbed and a micro-pixel centroiding experiment currently under development at the National Space Science Center, Chinese Academy of Sciences. We discuss on-going development efforts aimed at calibrating the intra-/inter-pixel quantum efficiency and pixel positions for scientific grade CMOS detector, and review significant progress in achieving higher precision differential centroiding for pseudo star images in large area back-illuminated CMOS detector. Without calibration of pixel positions and intrapixel response, we have demonstrated that the standard deviation of differential centroiding is below 2.0e-3 pixels.

Personalized Age Progression with Bi-Level Aging Dictionary Learning.

PubMed

Shu, Xiangbo; Tang, Jinhui; Li, Zechao; Lai, Hanjiang; Zhang, Liyan; Yan, Shuicheng

2018-04-01

Age progression is defined as aesthetically re-rendering the aging face at any future age for an individual face. In this work, we aim to automatically render aging faces in a personalized way. Basically, for each age group, we learn an aging dictionary to reveal its aging characteristics (e.g., wrinkles), where the dictionary bases corresponding to the same index yet from two neighboring aging dictionaries form a particular aging pattern cross these two age groups, and a linear combination of all these patterns expresses a particular personalized aging process. Moreover, two factors are taken into consideration in the dictionary learning process. First, beyond the aging dictionaries, each person may have extra personalized facial characteristics, e.g., mole, which are invariant in the aging process. Second, it is challenging or even impossible to collect faces of all age groups for a particular person, yet much easier and more practical to get face pairs from neighboring age groups. To this end, we propose a novel Bi-level Dictionary Learning based Personalized Age Progression (BDL-PAP) method. Here, bi-level dictionary learning is formulated to learn the aging dictionaries based on face pairs from neighboring age groups. Extensive experiments well demonstrate the advantages of the proposed BDL-PAP over other state-of-the-arts in term of personalized age progression, as well as the performance gain for cross-age face verification by synthesizing aging faces.

75 FR 39801 - Airworthiness Directives; McCauley Propeller Systems Model 4HFR34C653/L106FA Propellers

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-13

...) 946-4148; fax (316) 946-4107. SUPPLEMENTARY INFORMATION: The FAA proposed to amend 14 CFR part 39 with....gov ; telephone (316) 946-4148; fax: (316) 946-4107, for more information about this AD. Material...

7 CFR 3560.653 - Prepayment requests.

Code of Federal Regulations, 2010 CFR

2010-01-01

... of lease language to be used during the period between the submission date and the final resolution... request. The Agency will notify nonprofit organizations and public bodies involved in providing affordable...). Additionally, the Agency is to notify nonprofit organizations and public bodies whenever a borrower, who has...

7 CFR 3560.653 - Prepayment requests.

Code of Federal Regulations, 2011 CFR

2011-01-01

... of lease language to be used during the period between the submission date and the final resolution... request. The Agency will notify nonprofit organizations and public bodies involved in providing affordable...). Additionally, the Agency is to notify nonprofit organizations and public bodies whenever a borrower, who has...

7 CFR 3560.653 - Prepayment requests.

Code of Federal Regulations, 2014 CFR

2014-01-01

... of lease language to be used during the period between the submission date and the final resolution... request. The Agency will notify nonprofit organizations and public bodies involved in providing affordable...). Additionally, the Agency is to notify nonprofit organizations and public bodies whenever a borrower, who has...

7 CFR 3560.653 - Prepayment requests.

Code of Federal Regulations, 2012 CFR

2012-01-01

... of lease language to be used during the period between the submission date and the final resolution... request. The Agency will notify nonprofit organizations and public bodies involved in providing affordable...). Additionally, the Agency is to notify nonprofit organizations and public bodies whenever a borrower, who has...

7 CFR 3560.653 - Prepayment requests.

Code of Federal Regulations, 2013 CFR

2013-01-01

... of lease language to be used during the period between the submission date and the final resolution... request. The Agency will notify nonprofit organizations and public bodies involved in providing affordable...). Additionally, the Agency is to notify nonprofit organizations and public bodies whenever a borrower, who has...

20 CFR 653.500 - Purpose and scope of subpart.

Code of Federal Regulations, 2012 CFR

2012-04-01

... year round basis. Orders seeking workers to perform agricultural or food processing work on a year round basis which involves permanent relocation are not subject to the requirements of this subpart... interstate clearance systems for less than year round agricultural or food processing work. ...

20 CFR 653.500 - Purpose and scope of subpart.

Code of Federal Regulations, 2011 CFR

2011-04-01

... year round basis. Orders seeking workers to perform agricultural or food processing work on a year round basis which involves permanent relocation are not subject to the requirements of this subpart... interstate clearance systems for less than year round agricultural or food processing work. ...

20 CFR 653.500 - Purpose and scope of subpart.

Code of Federal Regulations, 2014 CFR

2014-04-01

... year round basis. Orders seeking workers to perform agricultural or food processing work on a year round basis which involves permanent relocation are not subject to the requirements of this subpart... interstate clearance systems for less than year round agricultural or food processing work. ...

20 CFR 653.500 - Purpose and scope of subpart.

Code of Federal Regulations, 2013 CFR

2013-04-01

... year round basis. Orders seeking workers to perform agricultural or food processing work on a year round basis which involves permanent relocation are not subject to the requirements of this subpart... interstate clearance systems for less than year round agricultural or food processing work. ...

36 CFR 65.3 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-07-01

... definable area, urban or rural, that possesses a significant concentration, linkage or continuity of sites, buildings, structures or objects united by past events or aesthetically by plan or physical development. A... impact that will destroy or seriously damage the resources which make it eligible for National Historic...

36 CFR 65.3 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-07-01

... definable area, urban or rural, that possesses a significant concentration, linkage or continuity of sites, buildings, structures or objects united by past events or aesthetically by plan or physical development. A... impact that will destroy or seriously damage the resources which make it eligible for National Historic...

36 CFR 65.3 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-07-01

... definable area, urban or rural, that possesses a significant concentration, linkage or continuity of sites, buildings, structures or objects united by past events or aesthetically by plan or physical development. A... impact that will destroy or seriously damage the resources which make it eligible for National Historic...

36 CFR 65.3 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-07-01

... definable area, urban or rural, that possesses a significant concentration, linkage or continuity of sites, buildings, structures or objects united by past events or aesthetically by plan or physical development. A... impact that will destroy or seriously damage the resources which make it eligible for National Historic...

48 CFR 319.501 - General.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false General. 319.501 Section 319.501 Federal Acquisition Regulations System HEALTH AND HUMAN SERVICES SOCIOECONOMIC PROGRAMS SMALL...'s recommendation on Form HHS 653, HHS Small Business Review Form, the SBS shall review each proposed...

20 CFR 653.107 - Outreach.

Code of Federal Regulations, 2010 CFR

2010-04-01

... Administrator as part of the program budget plan (PBP) process. Wherever feasible, State agencies shall... requirement, shall be reviewed by the Regional Administrator during the annual PBP approval process. The State.... (g) As part of the annual PBP process, funding of State agencies shall be contingent upon the...

Study of visible luminescence spectra from Nd3+ doped TPO glass upon 808 nm excitation

NASA Astrophysics Data System (ADS)

Azam, Mohd; Rai, Vineet Kumar

2018-05-01

The Nd3+ doped TPO glasses have been prepared by melting and quenching method using the high temperature electric furnace. The upconversion (UC) spectra of Nd3+ doped TPO glasses at different concentration of rare ions have been recorded in the 400-700 nm wavelength range upon 808 nm laser excitation source. In the UC emission process, there are four bands centered at ˜495 nm, 546 nm, 602 nm and 653 nm respectively in the visible range were observed. But the green and red bands centered at˜546 nm and ˜653 nm corresponding to the 4G7/2 → 4I9/2 and 4G7/2 → 4I13/2 transitions respectively have been observed as the strong bands. The UC emission mechanism was observed as two photon process. The material can be used as a good NIR to visible upconverter and non-colour tunable display.

Investigation of thermal treatment on selective separation of post consumer plastics prior to froth flotation.

PubMed

Guney, Ali; Poyraz, M Ibrahim; Kangal, Olgac; Burat, Firat

2013-09-01

Plastics have become the widely used materials because of their advantages, such as cheapness, endurance, lightness, and hygiene. However, they cause waste and soil pollution and they do not easily decompose. Many promising technologies are being investigated for separating mixed thermoplastics, but they are still uneconomical and unreliable. Depending on their surface characteristics, these plastics can be separated from each other by flotation method which is useful mineral processing technique with its low cost and simplicity. The main objective of this study is to investigate the flotation characteristics of PET and PVC and determine the effect of plasticizer reagents on efficient plastic separation. For that purpose, various parameters such as pH, plasticizer concentration, plasticizer type, conditioning temperature and thermal conditioning were investigated. As a result, PET particles were floated with 95.1% purity and 65.3% efficiency while PVC particles were obtained with 98.1% purity and 65.3% efficiency. Copyright © 2013 Elsevier Ltd. All rights reserved.

Microstructure and Mechanical Behavior of Amorphous Al-Cu-Ti Metal Foams Synthesized by Spark Plasma Sintering

NASA Astrophysics Data System (ADS)

Li, Maoyuan; Lu, Lin; Dai, Zhen; Hong, Yiqiang; Chen, Weiwei; Zhang, Yuping; Qiao, Yingjie

Amorphous Al-Cu-Ti metal foams were prepared by spark plasma sintering (SPS) process with the diameter of 10mm. The SPS process was conducted at the pressure of 200 and 300MPa with the temperature of 653-723K, respectively. NaCl was used as the space-holder, forming almost separated pores with the porosity of 65 vol%. The microstructure and mechanical behavior of the amorphous Al-Cu-Ti metal foams were systematically investigated. The results show that the crystallinity increased at elevated temperatures. The effect of pressure and holding time on the crystallization was almost negligible. The intermetallic compounds, i.e. Al-Ti, Al-Cu and Al-Cu-Ti were identified from X-ray diffraction (XRD) patterns. It was found that weak adhesion and brittle intermetallic compounds reduced the mechanical properties, while lower volume fraction and smaller size of NaCl powders improved the mechanical properties.

Progression from Mild Cognitive Impairment to Alzheimer's disease: effects of gender, butyrylcholinesterase genotype and rivastigmine treatment

PubMed Central

Ferris, Steven; Nordberg, Agneta; Soininen, Hilkka; Darreh-Shori, Taher; Lane, Roger

2014-01-01

Objective Evaluate the influence of gender and butyrylcholinesterase (BuChE) genotype on incidence of progression to AD, rate of cognitive and functional decline, and response to rivastigmine treatment in mild cognitive impairment (MCI) subjects. Methods This retrospective exploratory analysis from a 3–4 year, randomized, placebo-controlled study of rivastigmine in MCI subjects included participants who consented to pharmacogenetic testing. Results Of 1018 total patients, 490 (253 [52%] female) were successfully genotyped for BuChE. In subjects receiving placebo, the BuChE wt/wt genotype was associated with a statistically significantly higher rate of progression to AD and functional decline in women, compared with men with the BuChE wt/wt genotype. In subjects with a BuChE-K allele receiving placebo, incidence of progression to AD and rate of functional decline were not significantly different by gender, however cognitive decline was significantly faster in men. Statistically significant benefits of rivastigmine treatment on progression to AD, functional decline, ventricular volume expansion, whole brain atrophy and white matter loss were evident in female BuChE wt/wt. Conclusion Gender appears to differentially influence the type of decline in MCI subjects according to BuChE genotype, with more rapid progression of cognitive decline in male BuChE-K, and more rapid progression to AD and functional decline in female BuChE wt/wt. Cognitive decline in male BuChE-K and functional decline and progression to AD in female BuChE wt/wt were significantly attenuated by rivastigmine. Rivastigmine treatment also significantly reduced ventricular expansion, whole brain atrophy rate and white matter loss in female BuChE wt/wt, suggesting a possible disease-modifying effect. PMID:19617863

ProtocolNavigator: emulation-based software for the design, documentation and reproduction biological experiments.

PubMed

Khan, Imtiaz A; Fraser, Adam; Bray, Mark-Anthony; Smith, Paul J; White, Nick S; Carpenter, Anne E; Errington, Rachel J

2014-12-01

Experimental reproducibility is fundamental to the progress of science. Irreproducible research decreases the efficiency of basic biological research and drug discovery and impedes experimental data reuse. A major contributing factor to irreproducibility is difficulty in interpreting complex experimental methodologies and designs from written text and in assessing variations among different experiments. Current bioinformatics initiatives either are focused on computational research reproducibility (i.e. data analysis) or laboratory information management systems. Here, we present a software tool, ProtocolNavigator, which addresses the largely overlooked challenges of interpretation and assessment. It provides a biologist-friendly open-source emulation-based tool for designing, documenting and reproducing biological experiments. ProtocolNavigator was implemented in Python 2.7, using the wx module to build the graphical user interface. It is a platform-independent software and freely available from http://protocolnavigator.org/index.html under the GPL v2 license. © The Author 2014. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

77 FR 15390 - Certain Handbags, Luggage, Accessories, and Packaging Thereof; Notice of Request for Statements...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-15

..., and packaging thereof that infringe U.S. Trademark Registration Nos. 297,594; 1,643,625; 1,653,663; 2,773,107; 2,177,828; 2,181,753; and 1,519,828 registered to complainants Louis Vuitton Malletier S.A...

30 CFR 285.800 - How must I conduct my activities to comply with safety and environmental requirements?

Code of Federal Regulations, 2011 CFR

2011-07-01

..., Inspections, and Facility Assessments for Activities Conducted Under SAPs, COPs and GAPs § 285.800 How must I... approved SAP, COP, or GAP, as required under §§ 285.615(c), 285.633(b), or 285.653(c). ...

75 FR 81894 - Safeguarding Child Support Information

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-29

... in cases involving domestic violence or child abuse. Section 453A of the Act, 42 U.S.C. 653a... have been raised by commenters, Departmental officials, media coverage, litigation and program... noted that Appendix C did not reference the domestic violence language referenced in both Appendices A...

Diatomite

USGS Publications Warehouse

Founie, A.

2006-01-01

In 2005, diatomite production in the United States reached 653 kt, a 5% increased over 2004. Production came from six companies with 12 processing facilities in four states. California and Nevada accounted for 70% of US production in 2005. Other than the United States, significant producers included China, Denmark, Japan, France and Mexico.

Psychopathy as a Taxon: Evidence That Psychopaths Are a Discrete Class.

ERIC Educational Resources Information Center

Harris, Grant T.; And Others

1994-01-01

Applied taxometric analyses to construct of psychopathy (as measured by Psychopathy Checklist) and to several variables reflecting antisocial childhood, adult criminality, and criminal recidivism. Findings from 653 serious offenders assessed or treated in maximum-security institution supported existence of taxon underlying psychopathy. Childhood…

20 CFR 653.503 - Field checks.

Code of Federal Regulations, 2010 CFR

2010-04-01

... of agricultural worksites to which JS placements have been made through the intrastate or interstate.... Both the employees and the employer shall be consulted, and JS shall determine and document whether wages, hours, working and housing conditions are as specified in job orders. JS staff shall keep records...

Jackpot Structural Features: Rollover Effect and Goal-Gradient Effect in EGM Gambling.

PubMed

Li, En; Rockloff, Matthew J; Browne, Matthew; Donaldson, Phillip

2016-06-01

Relatively little research has been undertaken on the influence of jackpot structural features on electronic gaming machine (EGM) gambling behavior. This study considered two common features of EGM jackpots: progressive (i.e., the jackpot incrementally growing in value as players make additional bets), and deterministic (i.e., a guaranteed jackpot after a fixed number of bets, which is determined in advance and at random). Their joint influences on player betting behavior and the moderating role of jackpot size were investigated in a crossed-design experiment. Using real money, players gambled on a computer simulated EGM with real jackpot prizes of either $500 (i.e., small jackpot) or $25,000 (i.e., large jackpot). The results revealed three important findings. Firstly, players placed the largest bets (20.3 % higher than the average) on large jackpot EGMs that were represented to be deterministic and non-progressive. This finding was supportive of a hypothesized 'goal-gradient effect', whereby players might have felt subjectively close to an inevitable payoff for a high-value prize. Secondly, large jackpots that were non-deterministic and progressive also promoted high bet sizes (17.8 % higher than the average), resembling the 'rollover effect' demonstrated in lottery betting, whereby players might imagine that their large bets could be later recouped through a big win. Lastly, neither the hypothesized goal-gradient effect nor the rollover effect was evident among players betting on small jackpot machines. These findings suggest that certain high-value jackpot configurations may have intensifying effects on player behavior.

e-Learning competency for practice nurses: an evaluation report.

PubMed

Heartfield, Marie; Morello, Andrea; Harris, Melanie; Lawn, Sharon; Pols, Vincenza; Stapleton, Carolyn; Battersby, Malcolm

2013-01-01

Practice nurses in Australia are now funded to facilitate chronic condition management, including self-management support. Chronic disease management requires an established rapport, support and proactivity between general practitioners, patients and the practice nurses. To achieve this, training in shared decision making is needed. e-Learning supports delivery and achievement of such policy outcomes, service improvements and skill development. However, e-learning effectiveness for health care professionals' is determined by several organisational, economic, pedagogical and individual factors, with positive e-learning experience linked closely to various supports. This paper reinforces previous studies showing nurses' expanding role across general practice teams and reports on some of the challenges of e-learning. Merely providing practice nurses with necessary information via web-based learning systems does not ensure successful learning or progress toward improving health outcomes for patients.

Development of microwave-multiplexed superconductive detectors for the HOLMES experiment

NASA Astrophysics Data System (ADS)

Giachero, A.; Becker, D.; Bennett, D. A.; Faverzani, M.; Ferri, E.; Fowler, J. W.; Gard, J. D.; Hays-Wehle, J. P.; Hilton, G. C.; Maino, M.; Mates, J. A. B.; Puiu, A.; Nucciotti, A.; Reintsema, C. D.; Swetz, D. S.; Ullom, J. N.; Vale, L. R.

2016-05-01

In recent years, the progress on low temperature detector technologies has allowed design of large scale experiments aiming at pushing down the sensitivity on the neutrino mass below 1 eV. Even with outstanding performances in both energy (~eV on keV) and time resolution (~ 1 μs) on the single channel, a large number of detectors working in parallel is required to reach a sub-eV sensitivity. HOLMES is a new experiment to directly measure the neutrino mass with a sensitivity as low as 2eV. HOLMES will perform a calorimetric measurement of the energy released in the electron capture (EC) decay of 163 Ho. In its final configuration, HOLMES will deploy 1000 detectors of low temperature microcalorimeters with implanted 163 Ho nuclei. The baseline sensors for HOLMES are Mo/Cu TESs (Transition Edge Sensors) on SiNx membrane with gold absorbers. The readout is based on the use of rf-SQUIDs as input devices with flux ramp modulation for linearization purposes; the rf-SQUID is then coupled to a superconducting lambda/4-wave resonator in the GHz range, and the modulated signal is finally read out using the homodyne technique. The TES detectors have been designed with the aim of achieving an energy resolution of a few eV at the spectrum endpoint and a time resolution of a few micro-seconds, in order to minimize pile-up artifacts.

Progress on the Implementation of a Neutral Beam for the Lithium Tokamak eXperiment-Beta

NASA Astrophysics Data System (ADS)

Merino, Enrique; Kozub, Thomas; Boyle, Dennis; Majeski, Richard; Kaita, Robert; Smirnov, Artem; Catalano, Ryan

2016-10-01

In the Lithium Tokamak eXperiment (LTX), good performance discharges have been achieved with reduced-recycling lithium walls. Two hydrogen neutral beams (NB) have been loaned to the LTX project by Tri-Alpha Energy, Inc. To further improve plasma parameters, one of these neutral beams is being installed as part of an upgrade to LTX (LTX-Beta). Current ohmic input power in LTX is less than 100 kW. The NB will provide core plasma fueling with up to 700 kW of injected power. Requirements for accommodating the NB include the addition of injection and beam-dump ports on the vessel, and their designs have been finalized. Progress has also been made on the NB power supplies, including the preparation of a new room to accommodate them. A description of these activities and the status of other improvements to LTX for LTX-Beta will be presented. Work supported by US DOE contracts DE-AC02- 09CH11466 and DE-AC05- 00OR22725.

Etiologic classification of TIA and minor stroke by A-S-C-O and causative classification system as compared to TOAST reduces the proportion of patients categorized as cause undetermined.

PubMed

Desai, Jamsheed A; Abuzinadah, Ahmad R; Imoukhuede, Oje; Bernbaum, Manya L; Modi, Jayesh; Demchuk, Andrew M; Coutts, Shelagh B

2014-01-01

The assortment of patients based on the underlying pathophysiology is central to preventing recurrent stroke after a transient ischemic attack and minor stroke (TIA-MS). The causative classification of stroke (CCS) and the A-S-C-O (A for atherosclerosis, S for small vessel disease, C for Cardiac source, O for other cause) classification schemes have recently been developed. These systems have not been specifically applied to the TIA-MS population. We hypothesized that both CCS and A-S-C-O would increase the proportion of patients with a definitive etiologic mechanism for TIA-MS as compared with TOAST. Patients were analyzed from the CATCH study. A single-stroke physician assigned all patients to an etiologic subtype using published algorithms for TOAST, CCS and ASCO. We compared the proportions in the various categories for each classification scheme and then the association with stroke progression or recurrence was assessed. TOAST, CCS and A-S-C-O classification schemes were applied in 469 TIA-MS patients. When compared to TOAST both CCS (58.0 vs. 65.3%; p < 0.0001) and ASCO grade 1 or 2 (37.5 vs. 65.3%; p < 0.0001) assigned fewer patients as cause undetermined. CCS had increased assignment of cardioembolism (+3.8%, p = 0.0001) as compared with TOAST. ASCO grade 1 or 2 had increased assignment of cardioembolism (+8.5%, p < 0.0001), large artery atherosclerosis (+14.9%, p < 0.0001) and small artery occlusion (+4.3%, p < 0.0001) as compared with TOAST. Compared with CCS, using ASCO resulted in a 20.5% absolute reduction in patients assigned to the 'cause undetermined' category (p < 0.0001). Patients who had multiple high-risk etiologies either by CCS or ASCO classification or an ASCO undetermined classification had a higher chance of having a recurrent event. Both CCS and ASCO schemes reduce the proportion of TIA and minor stroke patients classified as 'cause undetermined.' ASCO resulted in the fewest patients classified as cause undetermined. Stroke recurrence after TIA-MS is highest in patients with multiple high-risk etiologies or cryptogenic stroke classified by ASCO. © 2014 S. Karger AG, Basel.

Relationship between adverse childhood experiences and homelessness and the impact of axis I and II disorders.

PubMed

Roos, Leslie E; Mota, Natalie; Afifi, Tracie O; Katz, Laurence Y; Distasio, Jino; Sareen, Jitender

2013-12-01

We investigated the links between homelessness associated with serious mental and physical healthy disparities and adverse childhood experiences (ACEs) in nationally representative data, with Axis I and II disorders as potential mediators. We examined data from the National Epidemiologic Survey of Alcohol and Related Conditions in 2001-2002 and 2004-2005, and included 34,653 participants representative of the noninstitutionalized US population who were 20 years old or older. We studied the variables related to 4 classes of Axis I disorders, all 10 Axis II personality disorders, a wide range of ACEs, and a lifetime history of homelessness. Analyses revealed high prevalences of each ACE in individuals experiencing lifetime homelessness (17%-60%). A mediation model with Axis I and II disorders determined that childhood adversities were significantly related to homelessness through direct effects (adjusted odd ratios = 2.04, 4.24) and indirect effects, indicating partial mediation. Population attributable fractions were also reported. Although Axis I and II disorders partially mediated the relationship between ACEs and homelessness, a strong direct association remained. This novel finding has implications for interventions and policy. Additional research is needed to understand relevant causal pathways.

[Patient's Experience with Living Donation: A Questionnaire-Based Survey of 144 Living Kidney Donors].

PubMed

Schieber, Katharina; Gaag, Sonja; Heller, Katharina; Erim, Yesim

2018-05-01

Living organ donation becomes more and more important as the number of patients needing organ transplantation is increasing. The University Hospital of Erlangen initiated a survey of living kidney donors to improve the process of living donation. The survey aimed to assess the donor's needs and experiences during the process of living kidney donation. From 2003 to 2014 n=199 living kidney donations were registered at the University Hospital of Erlangen. A total of n=144 living kidney donors (65.3% females, mean age M=58.7 years) participated in the study. In general, the majority of the living kidney donors were satisfied with the process of donation. Almost all of them (98%) confirmed to donate again, if it was possible. A large part of the living kidney donors denied any negative physical or psychological consequences of the donation. However, around 25% reported still physical problems for example wound healing, pain or long-term hypertension. Furthermore, a lack of pre- and post-operative psychological care or a regular medical follow-up care was reported. Thus, clinical practice needs to be further developed to meet the patient's needs. © Georg Thieme Verlag KG Stuttgart · New York.

Gender differences in the associations of gambling activities and suicidal behaviors with problem gambling in a nationally representative French sample.

PubMed

Husky, Mathilde M; Michel, Grégory; Richard, Jean-Baptiste; Guignard, Romain; Beck, François

2015-06-01

The objectives of the present study are to describe gender differences in factors associated with moderate risk and problem gambling. Data were extracted from the 2010 Health Barometer, a large survey on a representative sample of the general population aged 15-85 years living in France (n=27,653), carried out by the National Institute for Health Promotion and Health Education. Data were collected between October 2009 and July 2010. A computer-assisted telephone interview system was used. The findings indicate that men are three times more likely to experience problems with gambling. Men and women have different patterns of gambling activities. Men were more involved with Rapido, internet gambling, sports and racetrack betting, poker, and casino tables, whereas women gambled more often on scratch games. Both men and women engaging in immediate reward games were significantly more likely to experience difficulties with gambling. This association, however, was stronger in women. Furthermore, suicidal ideation and behaviors were more likely to be associated with gambling problems in women as compared to men. The study underscores the importance of considering gender-related differences in the study of gambling behaviors. Copyright © 2015 Elsevier Ltd. All rights reserved.

Combined Use of Integral Experiments and Covariance Data

NASA Astrophysics Data System (ADS)

Palmiotti, G.; Salvatores, M.; Aliberti, G.; Herman, M.; Hoblit, S. D.; McKnight, R. D.; Obložinský, P.; Talou, P.; Hale, G. M.; Hiruta, H.; Kawano, T.; Mattoon, C. M.; Nobre, G. P. A.; Palumbo, A.; Pigni, M.; Rising, M. E.; Yang, W.-S.; Kahler, A. C.

2014-04-01

In the frame of a US-DOE sponsored project, ANL, BNL, INL and LANL have performed a joint multidisciplinary research activity in order to explore the combined use of integral experiments and covariance data with the objective to both give quantitative indications on possible improvements of the ENDF evaluated data files and to reduce at the same time crucial reactor design parameter uncertainties. Methods that have been developed in the last four decades for the purposes indicated above have been improved by some new developments that benefited also by continuous exchanges with international groups working in similar areas. The major new developments that allowed significant progress are to be found in several specific domains: a) new science-based covariance data; b) integral experiment covariance data assessment and improved experiment analysis, e.g., of sample irradiation experiments; c) sensitivity analysis, where several improvements were necessary despite the generally good understanding of these techniques, e.g., to account for fission spectrum sensitivity; d) a critical approach to the analysis of statistical adjustments performance, both a priori and a posteriori; e) generalization of the assimilation method, now applied for the first time not only to multigroup cross sections data but also to nuclear model parameters (the "consistent" method). This article describes the major results obtained in each of these areas; a large scale nuclear data adjustment, based on the use of approximately one hundred high-accuracy integral experiments, will be reported along with a significant example of the application of the new "consistent" method of data assimilation.

31 CFR 339.7 - Preservation of rights.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 31 Money and Finance: Treasury 2 2010-07-01 2010-07-01 false Preservation of rights. 339.7 Section 339.7 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) FISCAL SERVICE... H § 339.7 Preservation of rights. The provisions of Treasury Department Circulars Nos. 530, 653, and...

Marketing Academics' Perceptions of the Peer Review Process

ERIC Educational Resources Information Center

Bailey, Charles D.; Hair, Joe F.; Hermanson, Dana R.; Crittenden, Victoria L.

2012-01-01

Publication in refereed journals is critical to career success for most marketing faculty members, and the peer review process is the gatekeeper for a refereed journal. The study reported here examines marketing academics' perceptions of this peer review process. Based on responses from 653 marketing academics, we find favorable overall…

32 CFR 65.3 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-07-01

...-called `A' School). (3) In the case of members of the Air Force, Basic Military Training and Technical..., U.S.C. Entry Level and Skill Training. (1) In the case of members of the Army, Basic Combat Training and Advanced Individual Training, which includes members attending One Station Unit Training (OSUT...

77 FR 49817 - Submission for OMB Review; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-17

... identity and comply with the statutory requirement that federal Office of Child Support Enforcement (OCSE... persons. 42 U.S.C. 653(m)(2). After identity is authenticated, secure accounts will be created for... directly to the following: Office of Management and Budget, Paperwork Reduction Project, 725 17th Street NW...

Crewmember in the middeck exercising on the MK-1 rowing machine (DTO 653).

NASA Image and Video Library

1994-04-20

STS059-11-014 (9-20 April 1994) --- Astronaut Michael R. (Rich) Clifford, mission specialist, uses the rowing machine temporarily deployed on the Space Shuttle Endeavour's middeck. Many of the crew members put in time on the device during the week and a half mission.

20 CFR 653.108 - State agency self-monitoring.

Code of Federal Regulations, 2011 CFR

2011-04-01

... wrap-up sessions with the local office manager and staff to discuss any obvious findings and offer.... (5) The local office manager shall develop and propose a written corrective action plan. The plan... 658.400 et seq. The State MSFW Monitor Advocate shall review the local office managers' informal...

20 CFR 653.108 - State agency self-monitoring.

Code of Federal Regulations, 2013 CFR

2013-04-01

... wrap-up sessions with the local office manager and staff to discuss any obvious findings and offer.... (5) The local office manager shall develop and propose a written corrective action plan. The plan... 658.400 et seq. The State MSFW Monitor Advocate shall review the local office managers' informal...

20 CFR 653.108 - State agency self-monitoring.

Code of Federal Regulations, 2012 CFR

2012-04-01

... wrap-up sessions with the local office manager and staff to discuss any obvious findings and offer.... (5) The local office manager shall develop and propose a written corrective action plan. The plan... 658.400 et seq. The State MSFW Monitor Advocate shall review the local office managers' informal...

20 CFR 653.108 - State agency self-monitoring.

Code of Federal Regulations, 2014 CFR

2014-04-01

... wrap-up sessions with the local office manager and staff to discuss any obvious findings and offer.... (5) The local office manager shall develop and propose a written corrective action plan. The plan... 658.400 et seq. The State MSFW Monitor Advocate shall review the local office managers' informal...

40 CFR 63.653 - Monitoring, recordkeeping, and implementation plan for emissions averaging.

Code of Federal Regulations, 2013 CFR

2013-07-01

... § 63.120 of subpart G; and (ii) For closed vent systems with control devices, conduct an initial design..., monitoring, recordkeeping, and reporting equivalent to that required for Group 1 emission points complying... control device. (2) The source shall implement the following procedures for each miscellaneous process...

40 CFR 421.246 - Pretreatment standards for new sources.

Code of Federal Regulations, 2011 CFR

2011-07-01

... wastewater pollutants in secondary nickel process wastewater introduced into a POTW shall not exceed the... slag input to reclaim process Chromium (total) 5.653 2.313 Copper 24.410 12.850 Nickel 24.670 16.320 (b) Acid reclaim leaching filtrate. PSNS for the Secondary Nickel Subcategory Pollutant or pollutant...

20 CFR 653.108 - State agency self-monitoring.

Code of Federal Regulations, 2010 CFR

2010-04-01

... compliance with JS regulations in serving MSFWs on an ongoing basis. The State Administrator shall have... Advocate shall: (1) Conduct an ongoing review of the delivery of services and protections afforded by JS... required reports, management information, the JS complaint system or otherwise are reviewed as soon as...

Improved Blackbody Simulator

DTIC Science & Technology

1974-06-01

28 - ABS Resins ................... 012 0.02 Carbon & Free-Cutting Steels%,. . . . . 27 - Acrylics ......................... 0.12 0.10 Alloy...Borosilicate Glasses................. 0.7 - Zinc At Its Alloys ................. 65.3 60.5 Alkyds .... .... .............. 010 0.20 Tungsten Carbide Cermet...cast).............47.6 25 ABS Resins ............ .. IS 3 FlowbnFie ........... 7 - Cellulose Acetate ............ &. 1.9 Pajadafi CW

47 CFR 73.6026 - Broadcast regulations applicable to Class A television stations.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Service on the Vertical Blanking Interval and in the Visual Signal. § 73.653Operation of TV aural and visual transmitters. § 73.658Affiliation agreements and network program practice; territorial exclusivity... informational programming for children. § 73.673Public information initiatives regarding educational and...

47 CFR 73.6026 - Broadcast regulations applicable to Class A television stations.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Service on the Vertical Blanking Interval and in the Visual Signal. § 73.653Operation of TV aural and visual transmitters. § 73.658Affiliation agreements and network program practice; territorial exclusivity... informational programming for children. § 73.673Public information initiatives regarding educational and...

Estimating timber losses from a town ant colony with aerial photographs

Treesearch

John C. Moser

1986-01-01

Aerial photographs were used to locate an individual nest of Atta texana (Buckley) and to estimate the area of damage in a plantation of loblolly pine (Pinus taeda L.). Stumpage loss from the nest over a period of 30 years was estimated to be $653.

Shifting closeness: interpersonal effects of personal goal progress.

PubMed

Fitzsimons, Gráinne M; Fishbach, Ayelet

2010-04-01

In this article, we examine how the shifting motivational priority of personal goals affects relationship closeness. We hypothesize that people will draw closer to significant others who are instrumental (vs. noninstrumental) for a goal that has not been progressing well-a goal that is thus high in motivational priority. Once the goal has progressed successfully, we predict that people will cease to draw closer to instrumental others. Five studies support these predictions by showing that the impact of goal progress on reduced preference for instrumental others (Experiment 1) depends on the framing of progress as partial attainment (vs. greater commitment, Experiment 2) and the intention to balance across goals (vs. focus on one goal; Experiments 3-4). We find that moving away from instrumental others post progress is functional, in that it allows for drawing closer to those who are instrumental for alternative goals (Experiment 5).

A Comparison of Computational Cognitive Models: Agent-Based Systems Versus Rule-Based Architectures

DTIC Science & Technology

2003-03-01

Java™ How To Program , Prentice Hall, 1999. Friedman-Hill, E., Jess, The Expert System Shell for the Java Platform, Sandia National Laboratories, 2001...transition from the descriptive NDM theory to a computational model raises several questions: Who is an experienced decision maker? How do you model the...progression from being a novice to an experienced decision maker? How does the model account for previous experiences? Are there situations where

Crotalidae polyvalent immune Fab: a guide to its use in North American crotaline envenomation.

PubMed

Keating, Gillian M; Lyseng-Williamson, Katherine A

2012-08-01

Intravenous crotalidae polyvalent immune Fab (CroFab(®)) is effective in patients with minimal, moderate or severe crotaline envenomation, halting the progression of local venom effects and ameliorating haematological and other systemic abnormalities of envenomation. Despite treatment, patients may experience delayed-onset or recurrent venom effects (e.g. coagulopathy). Intravenous crotalidae polyvalent immune Fab is generally well tolerated, with acute hypersensitivity reactions being the most commonly occurring adverse event.

Effects of Stereoscopic 3D Digital Radar Displays on Air Traffic Controller Performance

DTIC Science & Technology

2013-03-01

between men and women , but no significant influence was found. Experience in ATC was considered as a potential covariate that would be presumed to have...depicts altitude through the use of stereoscopic disparity, permitting vertical separation to be visually represented as differences in disparity...handling information via different sources (e.g., radar screen with a series of automated visual cues, paper or electronic flight progress strips, radio

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gorelenkov, Nikolai N

The area of energetic particle (EP) physics of fusion research has been actively and extensively researched in recent decades. The progress achieved in advancing and understanding EP physics has been substantial since the last comprehensive review on this topic by W.W. Heidbrink and G.J. Sadler [1]. That review coincided with the start of deuterium-tritium (DT) experiments on Tokamak Fusion Test reactor (TFTR) and full scale fusion alphas physics studies. Fusion research in recent years has been influenced by EP physics in many ways including the limitations imposed by the "sea" of Alfven eigenmodes (AE) in particular by the toroidicityinduced AEsmore » (TAE) modes and reversed shear Alfven (RSAE). In present paper we attempt a broad review of EP physics progress in tokamaks and spherical tori since the first DT experiments on TFTR and JET (Joint European Torus) including helical/stellarator devices. Introductory discussions on basic ingredients of EP physics, i.e. particle orbits in STs, fundamental diagnostic techniques of EPs and instabilities, wave particle resonances and others are given to help understanding the advanced topics of EP physics. At the end we cover important and interesting physics issues toward the burning plasma experiments such as ITER (International Thermonuclear Experimental Reactor).« less

Direct experimental visualization of the global Hamiltonian progression of two-dimensional Lagrangian flow topologies from integrable to chaotic state.

PubMed

Baskan, O; Speetjens, M F M; Metcalfe, G; Clercx, H J H

2015-10-01

Countless theoretical/numerical studies on transport and mixing in two-dimensional (2D) unsteady flows lean on the assumption that Hamiltonian mechanisms govern the Lagrangian dynamics of passive tracers. However, experimental studies specifically investigating said mechanisms are rare. Moreover, they typically concern local behavior in specific states (usually far away from the integrable state) and generally expose this indirectly by dye visualization. Laboratory experiments explicitly addressing the global Hamiltonian progression of the Lagrangian flow topology entirely from integrable to chaotic state, i.e., the fundamental route to efficient transport by chaotic advection, appear non-existent. This motivates our study on experimental visualization of this progression by direct measurement of Poincaré sections of passive tracer particles in a representative 2D time-periodic flow. This admits (i) accurate replication of the experimental initial conditions, facilitating true one-to-one comparison of simulated and measured behavior, and (ii) direct experimental investigation of the ensuing Lagrangian dynamics. The analysis reveals a close agreement between computations and observations and thus experimentally validates the full global Hamiltonian progression at a great level of detail.

IL-17A influences essential functions of the monocyte/macrophage lineage and is involved in advanced murine and human atherosclerosis.

PubMed

Erbel, Christian; Akhavanpoor, Mohammadreza; Okuyucu, Deniz; Wangler, Susanne; Dietz, Alex; Zhao, Li; Stellos, Konstantinos; Little, Kristina M; Lasitschka, Felix; Doesch, Andreas; Hakimi, Maani; Dengler, Thomas J; Giese, Thomas; Blessing, Erwin; Katus, Hugo A; Gleissner, Christian A

2014-11-01

Atherosclerosis is a chronic inflammatory disease. Lesion progression is primarily mediated by cells of the monocyte/macrophage lineage. IL-17A is a proinflammatory cytokine, which modulates immune cell trafficking and is involved inflammation in (auto)immune and infectious diseases. But the role of IL-17A still remains controversial. In the current study, we investigated effects of IL-17A on advanced murine and human atherosclerosis, the common disease phenotype in clinical care. The 26-wk-old apolipoprotein E-deficient mice were fed a standard chow diet and treated either with IL-17A mAb (n = 15) or irrelevant Ig (n = 10) for 16 wk. Furthermore, essential mechanisms of IL-17A in atherogenesis were studied in vitro. Inhibition of IL-17A markedly prevented atherosclerotic lesion progression (p = 0.001) by reducing inflammatory burden and cellular infiltration (p = 0.01) and improved lesion stability (p = 0.01). In vitro experiments showed that IL-17A plays a role in chemoattractance, monocyte adhesion, and sensitization of APCs toward pathogen-derived TLR4 ligands. Also, IL-17A induced a unique transcriptome pattern in monocyte-derived macrophages distinct from known macrophage types. Stimulation of human carotid plaque tissue ex vivo with IL-17A induced a proinflammatory milieu and upregulation of molecules expressed by the IL-17A-induced macrophage subtype. In this study, we show that functional blockade of IL-17A prevents atherosclerotic lesion progression and induces plaque stabilization in advanced lesions in apolipoprotein E-deficient mice. The underlying mechanisms involve reduced inflammation and distinct effects of IL-17A on monocyte/macrophage lineage. In addition, translational experiments underline the relevance for the human system. Copyright © 2014 by The American Association of Immunologists, Inc.

A Progress Report on Progress Files. The Experience of One Higher Education Institution

ERIC Educational Resources Information Center

East, Rob

2005-01-01

In order to facilitate personal development planning (PDP), the UK higher education sector is committed to introducing progress files. This article explores the experience of one institution in seeking to establish a system of progress files. It identifies the main practical problems in doing this, highlighting the lack of agreement on the skills…

Evaluation of 11 terrestrial carbon–nitrogen cycle models against observations from two temperate Free-Air CO2 Enrichment studies

PubMed Central

Zaehle, Sönke; Medlyn, Belinda E; De Kauwe, Martin G; Walker, Anthony P; Dietze, Michael C; Hickler, Thomas; Luo, Yiqi; Wang, Ying-Ping; El-Masri, Bassil; Thornton, Peter; Jain, Atul; Wang, Shusen; Warlind, David; Weng, Ensheng; Parton, William; Iversen, Colleen M; Gallet-Budynek, Anne; McCarthy, Heather; Finzi, Adrien; Hanson, Paul J; Prentice, I Colin; Oren, Ram; Norby, Richard J

2014-01-01

We analysed the responses of 11 ecosystem models to elevated atmospheric [CO2] (eCO2) at two temperate forest ecosystems (Duke and Oak Ridge National Laboratory (ORNL) Free-Air CO2 Enrichment (FACE) experiments) to test alternative representations of carbon (C)–nitrogen (N) cycle processes. We decomposed the model responses into component processes affecting the response to eCO2 and confronted these with observations from the FACE experiments. Most of the models reproduced the observed initial enhancement of net primary production (NPP) at both sites, but none was able to simulate both the sustained 10-yr enhancement at Duke and the declining response at ORNL: models generally showed signs of progressive N limitation as a result of lower than observed plant N uptake. Nonetheless, many models showed qualitative agreement with observed component processes. The results suggest that improved representation of above-ground–below-ground interactions and better constraints on plant stoichiometry are important for a predictive understanding of eCO2 effects. Improved accuracy of soil organic matter inventories is pivotal to reduce uncertainty in the observed C–N budgets. The two FACE experiments are insufficient to fully constrain terrestrial responses to eCO2, given the complexity of factors leading to the observed diverging trends, and the consequential inability of the models to explain these trends. Nevertheless, the ecosystem models were able to capture important features of the experiments, lending some support to their projections. PMID:24467623

Impressions of the Meson Spectrum: Hybrids & Exotics, present and future

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pennington, Michael R.

2016-03-25

It has long been expected that the spectrum of hadrons in QCD would be far richer and extensive than experiment has so far revealed. While there have been experimental hints of this richness for some time, it is really only in the last few years that dramatic progress has been seen in the exploration both experimentally and in calculations on the lattice. Precision studies enabled by new technology both with detectors and high performance computations are converging on an understanding of the spectrum in strong coupling QCD. These methodologies are laying the foundation for a decade of potential discovery thatmore » electro and photoproduction experiments at Jefferson Lab, which when combined with key results on B and charmonium decays from both e+e? and pp colliders, should turn mere impressions of the light meson spectrum into a high definition picture.« less

Autogenic-feedback training: A preventive method for space adaptation syndrome

NASA Technical Reports Server (NTRS)

Cowings, Patricia S.; Sharp, Joseph C.; Toscano, William B.; Kamiya, Joe; Miller, Neal E.

1987-01-01

The progress made to date on the reduction of data for Spacelab 3 Shuttle experiment, No. 3AFT23 is reported. Four astronauts participated as subjects in this experiment. Crewmen A and B served as treatment subjects (i.e., received preflight training for control of their own motion sickness symptoms) and Crewmen C and D served as control (i.e., did not receive training). A preliminary evaluation of Autogenic Feedback Training (AFT) was made from visual inspections of graphs that were generated from the preflight and inflight and inflight physiological data which included: (1) Baseline rotating chair tests for all crewmen; (2) Posttraining rotating chair tests of treatment groups subjects; (3) Preflight data from Joint Integrated Simulations for all crewmen; and (4) Flight data for all crewmen during mission days 0 through 4, and mission day 6 for treatment subjects only. A summary of the findings suggested by these data is outlined.

Protease-Activated Receptor-2 Deficiency Attenuates Atherosclerotic Lesion Progression and Instability in Apolipoprotein E-Deficient Mice

PubMed Central

Zuo, Pengfei; Zuo, Zhi; Zheng, Yueyue; Wang, Xin; Zhou, Qianxing; Chen, Long; Ma, Genshan

2017-01-01

Inflammatory mechanisms are involved in the process of atherosclerotic plaque formation and rupture. Accumulating evidence suggests that protease-activated receptor (PAR)-2 contributes to the pathophysiology of chronic inflammation on the vasculature. To directly examine the role of PAR-2 in atherosclerosis, we generated apolipoprotein E/PAR-2 double-deficient mice. Mice were fed with high-fat diet for 12 weeks starting at ages of 6 weeks. PAR-2 deficiency attenuated atherosclerotic lesion progression with reduced total lesion area, reduced percentage of stenosis and reduced total necrotic core area. PAR-2 deficiency increased fibrous cap thickness and collagen content of plaque. Moreover, PAR-2 deficiency decreased smooth muscle cell content, macrophage accumulation, matrix metallopeptidase-9 expression and neovascularization in plaque. Relative quantitative PCR assay using thoracic aorta revealed that PAR-2 deficiency reduced mRNA expression of inflammatory molecules, such as vascular cell adhesion molecule-1, intercellular adhesion molecule-1, tumor necrosis factor (TNF)-α and monocyte chemoattractant protein (MCP)-1. In vitro experiment, we found that PAR-2 deficiency reduced mRNA expression of interferon-γ, interleukin-6, TNF-α and MCP-1 in macrophage under unstimulated and lipopolysaccharide-stimulated conditions. These results suggest that PAR-2 deficiency attenuates the progression and instability of atherosclerotic plaque. PMID:28959204

Reasons for Using Electronic Cigarettes and Intentions to Quit Among Electronic Cigarette Users in Malaysia.

PubMed

Wong, Li Ping; Mohamad Shakir, Sharina Mahavera; Alias, Haridah; Aghamohammadi, Nasrin; Hoe, Victor Cw

2016-12-01

The rapidly increasing uptake of e-cigarettes in Malaysia as of late demands a study to identify factors leading to its increased popularity and user intentions to quit smoking e-cigarettes. A convenience sample of e-cigarette smokers visiting e-cigarette retail shops in Selangor and Kuala Lumpur was recruited. The majority of e-cigarette smokers were youth in colleges or universities (39 %), and young professionals and managers (36 %). The main reasons for using e-cigarettes were to help the user quit tobacco cigarettes (88 %), the perception that e-cigarettes are not as intrusive as tobacco cigarettes (85 %) and can be used in public areas (70 %), the perception that e-cigarettes are healthier than tobacco cigarettes (85 %), and its relatively lower cost compared to tobacco cigarettes (65 %). A total of 65.3 % of respondents expressed intentions to quit e-cigarettes. In a multivariate analysis, the respondents who earned monthly income of RM1000 or less were significantly more likely to intend to quit smoking e-cigarettes [OR 1.551; 95 % CI 1.022-2.355; p = 0.015] compared to the respondents who earned a monthly income of more than RM2000. The respondents who disagreed with the statement 'Smoking e-cigs is relatively cheaper compared to tobacco cigarettes' were significantly more likely to intend to quit smoking e-cigarettes [OR 1.548; 95 % CI 1.045-2.293; p = 0.027] compared to respondents who did not agree. e-cigarette preventive interventions should target areas related to the identified main reasons for using e-cigarettes, namely as an aid for quitting tobacco cigarettes, the perception that e-cigarettes are not as intrusive as tobacco cigarettes and can be used in public areas, the idea that e-cigarettes are healthier than tobacco cigarettes, and its relatively lower cost compared to tobacco cigarettes.

Spatial part-set cuing facilitation.

PubMed

Kelley, Matthew R; Parasiuk, Yuri; Salgado-Benz, Jennifer; Crocco, Megan

2016-07-01

Cole, Reysen, and Kelley [2013. Part-set cuing facilitation for spatial information. Journal of Experimental Psychology: Learning, Memory, & Cognition, 39, 1615-1620] reported robust part-set cuing facilitation for spatial information using snap circuits (a colour-coded electronics kit designed for children to create rudimentary circuit boards). In contrast, Drinkwater, Dagnall, and Parker [2006. Effects of part-set cuing on experienced and novice chess players' reconstruction of a typical chess midgame position. Perceptual and Motor Skills, 102(3), 645-653] and Watkins, Schwartz, and Lane [1984. Does part-set cuing test for memory organization? Evidence from reconstructions of chess positions. Canadian Journal of Psychology/Revue Canadienne de Psychologie, 38(3), 498-503] showed no influence of part-set cuing for spatial information when using chess boards. One key difference between the two procedures was that the snap circuit stimuli were explicitly connected to one another, whereas chess pieces were not. Two experiments examined the effects of connection type (connected vs. unconnected) and cue type (cued vs. uncued) on memory for spatial information. Using chess boards (Experiment 1) and snap circuits (Experiment 2), part-set cuing facilitation only occurred when the stimuli were explicitly connected; there was no influence of cuing with unconnected stimuli. These results are potentially consistent with the retrieval strategy disruption hypothesis, as well as the two- and three-mechanism accounts of part-set cuing.

Controlled progressive innate immune stimulation regimen prevents the induction of sickness behavior in the open field test

PubMed Central

Chen, Qun; Tarr, Andrew J; Liu, Xiaoyu; Wang, Yufen; Reed, Nathaniel S; DeMarsh, Cameron P; Sheridan, John F; Quan, Ning

2013-01-01

Peripheral immune activation by bacterial mimics or live replicating pathogens is well known to induce central nervous system activation. Sickness behavior alterations are often associated with inflammation-induced increases in peripheral proinflammatory cytokines (eg, interleukin [IL]-1β and IL-6). However, most researchers have used acute high dose endotoxin/bacterial challenges to observe these outcomes. Using this methodology may pose inherent risks in the translational interpretation of the experimental data in these studies. Studies using Escherichia coli have yet to establish the full kinetics of repeated E. coli peripheral injections. Therefore, we sought to examine the effects of repeated low dose E. coli on sickness behavior and local peripheral inflammation in the open field test. Results from the current experiments showed a behavioral dose response, where increased amounts of E. coli resulted in correspondingly increased sickness behavior. Furthermore, animals that received a subthreshold dose (ie, one that did not cause sickness behavior) of E. coli 24 hours prior were able to withstand a larger dose of E. coli on the second day (a dose that would normally cause sickness behavior in mice without prior exposure) without inducing sickness behavior. In addition, animals that received escalating subthreshold doses of E. coli on days 1 and 2 behaviorally tolerated a dose of E. coli 25 times higher than what would normally cause sickness behavior if given acutely. Lastly, increased levels of E. coli caused increased IL-6 and IL-1β protein expression in the peritoneal cavity, and this increase was blocked by administering a subthreshold dose of E. coli 24 hours prior. These data show that progressive challenges with subthreshold levels of E. coli may obviate the induction of sickness behavior and proinflammatory cytokine expression. PMID:23950656

Controlled progressive innate immune stimulation regimen prevents the induction of sickness behavior in the open field test.

PubMed

Chen, Qun; Tarr, Andrew J; Liu, Xiaoyu; Wang, Yufen; Reed, Nathaniel S; Demarsh, Cameron P; Sheridan, John F; Quan, Ning

2013-01-01

Peripheral immune activation by bacterial mimics or live replicating pathogens is well known to induce central nervous system activation. Sickness behavior alterations are often associated with inflammation-induced increases in peripheral proinflammatory cytokines (eg, interleukin [IL]-1β and IL-6). However, most researchers have used acute high dose endotoxin/bacterial challenges to observe these outcomes. Using this methodology may pose inherent risks in the translational interpretation of the experimental data in these studies. Studies using Escherichia coli have yet to establish the full kinetics of repeated E. coli peripheral injections. Therefore, we sought to examine the effects of repeated low dose E. coli on sickness behavior and local peripheral inflammation in the open field test. Results from the current experiments showed a behavioral dose response, where increased amounts of E. coli resulted in correspondingly increased sickness behavior. Furthermore, animals that received a subthreshold dose (ie, one that did not cause sickness behavior) of E. coli 24 hours prior were able to withstand a larger dose of E. coli on the second day (a dose that would normally cause sickness behavior in mice without prior exposure) without inducing sickness behavior. In addition, animals that received escalating subthreshold doses of E. coli on days 1 and 2 behaviorally tolerated a dose of E. coli 25 times higher than what would normally cause sickness behavior if given acutely. Lastly, increased levels of E. coli caused increased IL-6 and IL-1β protein expression in the peritoneal cavity, and this increase was blocked by administering a subthreshold dose of E. coli 24 hours prior. These data show that progressive challenges with subthreshold levels of E. coli may obviate the induction of sickness behavior and proinflammatory cytokine expression.

Child Abuse, Early Maladaptive Schemas, and Risky Sexual Behavior in College Women

ERIC Educational Resources Information Center

Roemmele, Melissa; Messman-Moore, Terri L.

2011-01-01

Previous research suggests that individuals abused as children are more likely to engage in risky sexual behavior during adulthood. The present study examined early maladaptive schemas as mediators of the child abuse-risky sexual behavior relationship among 653 college women. Self-report surveys assessed three forms of child abuse: Sexual,…

Counterinsurgency in the Philippines. Problems and Prospects

DTIC Science & Technology

1989-10-01

funds and the farmer-producers in the rural areas are practically begging for start-up funds with which to finance a backyard poultry farm, a cottage...257-70. Burton, Sandra. "Aquino’s Philippines: The Center Holds." Foreign Affairs 65:3 (America and the World 1986): 524-37. Butcher , Scott. U.S

24 CFR 5.653 - Section 8 project-based assistance programs: Admission-Income-eligibility and income-targeting.

Code of Federal Regulations, 2010 CFR

2010-04-01

... assistance programs, except for the moderate rehabilitation and the project-based certificate or voucher... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Section 8 project-based assistance... Disabilities: Family Income and Family Payment; Occupancy Requirements for Section 8 Project-Based Assistance...

24 CFR 5.653 - Section 8 project-based assistance programs: Admission-Income-eligibility and income-targeting.

Code of Federal Regulations, 2011 CFR

2011-04-01

... assistance programs, except for the moderate rehabilitation and the project-based certificate or voucher... 24 Housing and Urban Development 1 2011-04-01 2011-04-01 false Section 8 project-based assistance... Disabilities: Family Income and Family Payment; Occupancy Requirements for Section 8 Project-Based Assistance...

40 CFR 63.653 - Monitoring, recordkeeping, and implementation plan for emissions averaging.

Code of Federal Regulations, 2011 CFR

2011-07-01

... § 63.120 of subpart G; and (ii) For closed vent systems with control devices, conduct an initial design... different times, and/or in different submittals, later submittals may refer to earlier submittals instead of... controlled using a treatment process or series of treatment processes that achieves an emission reduction...

78 FR 54633 - Proposed Collection; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2013-09-05

.../Dissolution of a Same-Sex Domestic Partnership for DEERS Enrollment; DD x653 and DD x654; OMB Control Number 0704-TBD. Needs and Uses: Benefits shall be extended to same-sex domestic partners and, where applicable, children of same-sex domestic partners, once the DoD civilian and his/her same-sex domestic...

Clustering of Adolescent Dating Violence, Peer Violence, and Suicidal Behavior

ERIC Educational Resources Information Center

Bossarte, Robert M.; Simon, Thomas R.; Swahn, Monica H.

2008-01-01

To understand the co-occurrence of multiple types of violence, the authors developed a behavioral typology based on self-reports of suicidal behaviors, physical violence, and psychological abuse. Using a sample of dating adolescents from a high-risk school district, they identified five clusters of behaviors among the 1,653 students who reported…

Cleavage Mapping the Topology of Protein Folding Intermediates

DTIC Science & Technology

1995-03-13

1993). 29. Nakano, T., Antonino , L. C, Fox, R. O. & Fink, A. L. Effect of proline mutation on the stability and kinetics of folding of...Biochem. 62, 653-683. Nakano, T., Antonino , L. C., Fox, R. O., & Fink, A. L. (1993) Biochemistry 32, 2534-2541. Nozaki, Y. (1972) Methods Enzymol. 26, 43

The Influence of Self-Determination in Physical Education on Leisure-Time Physical Activity Behavior

ERIC Educational Resources Information Center

Shen, Bo; McCaughtry, Nate; Martin, Jeffrey

2007-01-01

Using a multitheory approach, this study was designed to investigate the influence of urban adolescents' perceived autonomy and competence in physical education on their physical activity intentions and behaviors during leisure time. A transcontextual model was hypothesized and tested. Urban adolescents (N = 653, ages 11-15 years) completed…

Disability in Occupations in a National Sample.

ERIC Educational Resources Information Center

Leigh, J. Paul; Fries, James F.

1992-01-01

Develops lists of jobs in which workers report functional disabilities, using 6,096 females and 3,653 males from the National Health and Nutrition Examination Survey I Epidemiological Follow-Up and attrition and mortality analyses for 6,911 women and 4,723 men. Occupational safety and health are critical to understanding functional disability…

32 CFR 552.168 - Fort Lewis Area Access Office.

Code of Federal Regulations, 2014 CFR

2014-07-01

...) Picture ID. (2) Address and telephone number. (3) Vehicle identification and license number, if a vehicle... of this subpart. (d) A wallet-sized permit (HFL Form 653) and a vehicle pass (HFL Form 652) will be... used, the estimated time of return, and the vehicle being used. (j) Except when land commitment has...

The Beginning of Wisdom

ERIC Educational Resources Information Center

Train, Russell E.

1977-01-01

Discusses the activities and influence of the Council on Environmental Quality in controlling air and water pollution. Concludes that we must develop a new awareness of our relationship with our environment and other forms of life if we are to maintain environments that sustain and enrich human life. For journal availability, see SO 505 653.…

Algorithm Development for the Multi-Fluid Plasma Model

DTIC Science & Technology

2011-05-30

392, Sep 1995. [13] L Chacon , DC Barnes, DA Knoll, and GH Miley. An implicit energy- conservative 2D Fokker-Planck algorithm. Journal of Computational...Physics, 157(2):618–653, 2000. [14] L Chacon , DC Barnes, DA Knoll, and GH Miley. An implicit energy- conservative 2D Fokker-Planck algorithm - II

14 CFR 121.655 - Applicability of reported weather minimums.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 14 Aeronautics and Space 3 2014-01-01 2014-01-01 false Applicability of reported weather minimums... § 121.655 Applicability of reported weather minimums. In conducting operations under §§ 121.649 through 121.653, the ceiling and visibility values in the main body of the latest weather report control for...

14 CFR 121.655 - Applicability of reported weather minimums.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 14 Aeronautics and Space 3 2013-01-01 2013-01-01 false Applicability of reported weather minimums... § 121.655 Applicability of reported weather minimums. In conducting operations under §§ 121.649 through 121.653, the ceiling and visibility values in the main body of the latest weather report control for...

14 CFR 121.655 - Applicability of reported weather minimums.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 14 Aeronautics and Space 3 2011-01-01 2011-01-01 false Applicability of reported weather minimums... § 121.655 Applicability of reported weather minimums. In conducting operations under §§ 121.649 through 121.653, the ceiling and visibility values in the main body of the latest weather report control for...

14 CFR 121.655 - Applicability of reported weather minimums.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 14 Aeronautics and Space 3 2012-01-01 2012-01-01 false Applicability of reported weather minimums... § 121.655 Applicability of reported weather minimums. In conducting operations under §§ 121.649 through 121.653, the ceiling and visibility values in the main body of the latest weather report control for...

14 CFR 121.655 - Applicability of reported weather minimums.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Applicability of reported weather minimums... § 121.655 Applicability of reported weather minimums. In conducting operations under §§ 121.649 through 121.653, the ceiling and visibility values in the main body of the latest weather report control for...

40 CFR 421.245 - Pretreatment standards for existing sources.

Code of Federal Regulations, 2011 CFR

2011-07-01

... existing sources. The mass of wastewater pollutants in secondary nickel process wastewater introduced into.../kg (pounds per million pounds) of slag input to reclaim process Chromium (total) 5.653 2.313 Copper 24.410 12.850 Nickel 24.670 16.320 (b) Acid reclaim leaching filtrate. PSES for the Secondary Nickel...

40 CFR 421.244 - Standards of performance for new sources.

Code of Federal Regulations, 2011 CFR

2011-07-01

.../kg (pounds per million pounds) of slag input to reclaim process Chromium (total) 5.653 2.313 Copper... range of 7.5 to 10.0 at all times. (b) Acid reclaim leaching filtrate. NSPS for the Secondary Nickel... all times. (c) Acid reclaim leaching belt filter backwash. NSPS for the Secondary Nickel Subcategory...

40 CFR 63.653 - Monitoring, recordkeeping, and implementation plan for emissions averaging.

Code of Federal Regulations, 2010 CFR

2010-07-01

...) For each emission point included in an emissions average, the owner or operator shall perform testing, monitoring, recordkeeping, and reporting equivalent to that required for Group 1 emission points complying... internal floating roof, external roof, or a closed vent system with a control device, as appropriate to the...

20 CFR 658.502 - Notification to employers.

Code of Federal Regulations, 2010 CFR

2010-04-01

... that it intends to discontinue the provision of JS services pursuant to 20 CFR part 653 and the reason... the laws involved. The employer shall be notified in writing that all JS services will be terminated... shall be notified that all JS services will be terminated within 20 working days unless the employer...

The Comparative Impacts of Social Justice Educational Methods on Political Participation, Civic Engagement, and Multicultural Activism

ERIC Educational Resources Information Center

Krings, Amy; Austic, Elizabeth A.; Gutiérrez, Lorraine M.; Dirksen, Kaleigh E.

2015-01-01

This cross-sectional, repeated measures, quasi-experimental study evaluates changes in college students' commitment toward, and confidence in, political participation, civic engagement, and multicultural activism. Our sample (n = 653) consisted of college students in a Midwestern university who participated in one of three social justice education…

75 FR 26211 - Combined Notice of Filings

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-11

...: 5 p.m. Eastern Time on Monday, May 10, 2010. Docket Numbers: RP10-653-000. Applicants: Discovery Gas.... Accession Number: 20100427-5175. Comment Date: 5 p.m. Eastern Time on Monday, May 10, 2010. Docket Numbers... Trading North America, LLC. Filed Date: 04/28/2010 Accession Number: 20100428-0211. Comment Date: 5 p.m...

40 CFR 65.3 - Compliance with standards and operation and maintenance requirements.

Code of Federal Regulations, 2010 CFR

2010-07-01

...)(4)(i) and (ii) do not apply to Group 2A or Group 2B process vents. Compliance with design, equipment, work practice, and operational standards, including those for equipment leaks, shall be determined... this part. (5) Design, equipment, work practice, or operational standards. Paragraphs (b)(5)(i) and (ii...

20 CFR 653.502 - Changes in crop and recruitment situations.

Code of Federal Regulations, 2010 CFR

2010-04-01

... in crop and recruitment situations. (a) If a labor demand State agency learns that a crop is maturing... eliminated the scheduled job opportunities, the State agencies involved shall make every effort to place the workers in alternate job opportunities as soon as possible, especially if the worker(s) is already enroute...

75 FR 7936 - Airworthiness Directives; SCHEIBE-Flugzeugbau GmbH Model SF 25C Gliders

Federal Register 2010, 2011, 2012, 2013, 2014

2010-02-23

... Airworthiness Directives; SCHEIBE-Flugzeugbau GmbH Model SF 25C Gliders AGENCY: Federal Aviation Administration.... Relevant Service Information SCHEIBE-Flugzeugbau GmbH has issued SCHEIBE AIRCRAFT GMBH Service Bulletin 653... SCHEIBE-Flugzeugbau GmbH: Amendment 39-16208; Docket No. FAA-2010-0125; Directorate Identifier 2010-CE-005...

40 CFR 59.653 - How do I test portable fuel containers?

Code of Federal Regulations, 2010 CFR

2010-07-01

.... Perform the following spout actuation and inversion steps at the end on the slosh testing, and at the end of the preconditioning soak. (i) Perform one complete actuation/inversion cycle per day for ten days. (ii) One actuation/inversion cycle consists of the following steps: (A) Remove and replace the spout...

Identity Exploration in the Dating Domain: The Role of Attachment Dimensions and Parenting Practices

ERIC Educational Resources Information Center

Pittman, Joe F.; Kerpelman, Jennifer L.; Soto, Janet B.; Adler-Baeder, Francesca M.

2012-01-01

We examined relations among perceived parenting practices (support and psychological control), attachment dimensions for romantic relationships (anxiety and avoidance) and exploration of the dating identity among actively dating adolescents in two high school aged samples. In the all female sample of Study 1 (n = 653) and the gender balanced…

20 CFR 653.101 - Provision of services to migrant and seasonal farmworkers (MSFWs).

Code of Federal Regulations, 2011 CFR

2011-04-01

... local offices, including itinerant and satellite offices, but exclusive of day-haul operations, offer services to both non-MSFWs and MSFWs. Separate farm labor service local offices, which offer only farmwork... agency and each local office shall offer to migrant and seasonal farmworkers (MSFWs) the full range of...

40 CFR 59.653 - How do I test portable fuel containers?

Code of Federal Regulations, 2011 CFR

2011-07-01

... PRODUCTS Control of Evaporative Emissions From New and In-Use Portable Fuel Containers Certifying Emission... container must be tested in their open condition unless they close automatically and are unlikely to be left open by the user during typical storage. All manual closures such as caps must be left off the...

The Physiological Effect of Compressive Forces on the Torso

DTIC Science & Technology

1946-12-19

changes during impacto During the course of these experiments in which impact loads were cautiously and progressively inoreasedp it was learned that...almost invar1ably de .--non- ~ strated before the application of ,I the impact force. ,:’" di . .Expv num- Impact Car ac contractJ.ons per minute ber...34 especially when the sub~ 0 ject would not synchronize the forced expiratory maneuver with the e onset of impacto f There is an appreciable period

DOE Office of Scientific and Technical Information (OSTI.GOV)

Guney, Ali; Poyraz, M. Ibrahim; Kangal, Olgac, E-mail: kangal@itu.edu.tr

Highlights: • Both PET and PVC have nearly the same densities. • The best pH value will be 4 for optimizing pH values. • Malic acid gave the best results for selective separation of PET and PVC. - Abstract: Plastics have become the widely used materials because of their advantages, such as cheapness, endurance, lightness, and hygiene. However, they cause waste and soil pollution and they do not easily decompose. Many promising technologies are being investigated for separating mixed thermoplastics, but they are still uneconomical and unreliable. Depending on their surface characteristics, these plastics can be separated from each othermore » by flotation method which is useful mineral processing technique with its low cost and simplicity. The main objective of this study is to investigate the flotation characteristics of PET and PVC and determine the effect of plasticizer reagents on efficient plastic separation. For that purpose, various parameters such as pH, plasticizer concentration, plasticizer type, conditioning temperature and thermal conditioning were investigated. As a result, PET particles were floated with 95.1% purity and 65.3% efficiency while PVC particles were obtained with 98.1% purity and 65.3% efficiency.« less

Human's choices in situations of time-based diminishing returns.

PubMed Central

Hackenberg, T D; Axtell, S A

1993-01-01

Three experiments examined adult humans' choices in situations with contrasting short-term and long-term consequences. Subjects were given repeated choices between two time-based schedules of points exchangeable for money: a fixed schedule and a progressive schedule that began at 0 s and increased by 5 s with each point delivered by that schedule. Under "reset" conditions, choosing the fixed schedule not only produced a point but it also reset the requirements of the progressive schedule to 0 s. In the first two experiments, reset conditions alternated with "no-reset" conditions, in which progressive-schedule requirements were independent of fixed-schedule choices. Experiment 1 entailed choices between a progressive-interval schedule and a fixed-interval schedule, the duration of which varied across conditions. Switching from the progressive- to the fixed-interval schedule was systematically related to fixed-interval size in 4 of 8 subjects, and in all subjects occurred consistently sooner in the progressive-schedule sequence under reset than under no-reset procedures. The latter result was replicated in a second experiment, in which choices between progressive- and fixed-interval schedules were compared with choices between progressive- and fixed-time schedules. In Experiment 3, switching patterns under reset conditions were unrelated to variations in intertrial interval. In none of the experiments did orderly choice patterns depend on verbal descriptions of the contingencies or on schedule-controlled response patterns in the presence of the chosen schedules. The overall pattern of results indicates control of choices by temporarily remote consequences, and is consistent with versions of optimality theory that address performance in situations of diminishing returns. PMID:8315364

Inhibition of E2F1 activity and cell cycle progression by arsenic via retinoblastoma protein.

PubMed

Sheldon, Lynn A

2017-01-01

The regulation of cell cycle progression by steroid hormones and growth factors is important for maintaining normal cellular processes including development and cell proliferation. Deregulated progression through the G1/S and G2/M cell cycle transitions can lead to uncontrolled cell proliferation and cancer. The transcription factor E2F1, a key cell cycle regulator, targets genes encoding proteins that regulate cell cycle progression through the G1/S transition as well as proteins important in DNA repair and apoptosis. E2F1 expression and activity is inhibited by inorganic arsenic (iAs) that has a dual role as a cancer therapeutic and as a toxin that leads to diseases including cancer. An understanding of what underlies this dichotomy will contribute to understanding how to use iAs as a more effective therapeutic and also how to treat cancers that iAs promotes. Here, we show that quiescent breast adenocarcinoma MCF-7 cells treated with 17-β estradiol (E2) progress through the cell cycle, but few cells treated with E2 + iAs progress from G1 into S-phase due to a block in cell cycle progression. Our data support a model in which iAs inhibits the dissociation of E2F1 from the tumor suppressor, retinoblastoma protein (pRB) due to changes in pRB phosphorylation which leads to decreased E2F1 transcriptional activity. These findings present an explanation for how iAs can disrupt cell cycle progression through E2F1-pRB and has implications for how iAs acts as a cancer therapeutic as well as how it may promote tumorigenesis through decreased DNA repair.

Use of Colistin and Other Critical Antimicrobials on Pig and Chicken Farms in Southern Vietnam and Its Association with Resistance in Commensal Escherichia coli Bacteria.

PubMed

Nguyen, Nhung T; Nguyen, Hoa M; Nguyen, Cuong V; Nguyen, Trung V; Nguyen, Men T; Thai, Hieu Q; Ho, Mai H; Thwaites, Guy; Ngo, Hoa T; Baker, Stephen; Carrique-Mas, Juan

2016-07-01

Antimicrobial resistance (AMR) is a global health problem, and emerging semi-intensive farming systems in Southeast Asia are major contributors to the AMR burden. We accessed 12 pig and chicken farms at key stages of production in Tien Giang Province, Vietnam, to measure antimicrobial usage and to investigate the prevalence of AMR to five critical antimicrobials (β-lactams, third-generation cephalosporins, quinolones, aminoglycosides, and polymyxins) and their corresponding molecular mechanisms among 180 Escherichia coli isolates. Overall, 94.7 mg (interquartile range [IQR], 65.3 to 151.1) and 563.6 mg (IQR, 398.9 to 943.6) of antimicrobials was used to produce 1 kg (live weight) of chicken and pig, respectively. A median of 3 (out of 8) critical antimicrobials were used on pig farms. E. coli isolates exhibited a high prevalence of resistance to ampicillin (97.8% and 94.4% for chickens and pigs, respectively), ciprofloxacin (73.3% and 21.1%), gentamicin (42.2% and 35.6%), and colistin (22.2% and 24.4%). The prevalence of a recently discovered colistin resistance gene, mcr-1, was 19 to 22% and had strong agreement with phenotypic colistin resistance. We conducted plasmid conjugation experiments with 37 mcr-1 gene-positive E. coli isolates and successfully observed transfer of the gene in 54.0% of isolates through a plasmid of approximately 63 kb, consistent with one recently identified in China. We found no significant correlation between total use of antimicrobials at the farm level and AMR. These data provide additional insight into the role of mcr-1 in colistin resistance on farms and outline the dynamics of phenotypic and genotypic AMR in semi-intensive farming systems in Vietnam. Our study provides accurate baseline information on levels of antimicrobial use, as well as on the dynamics of phenotypic and genotypic resistance for antimicrobials of critical importance among E. coli over the different stages of production in emerging pig and poultry production systems in Vietnam. E. coli isolates showed a high prevalence of resistance (>20%) to critically important antimicrobials, such as colistin, ciprofloxacin, and gentamicin. The underlying genetic mechanisms identified for colistin (the mcr-1 gene) and quinolone (gyrA gene mutations) are likely to play a major role in AMR to those compounds. Conjugation experiments led to the identification of a 63-kb plasmid, similar to one recently identified in China, as the potential carrier of the mcr-1 gene. These results should encourage greater restrictions of such antimicrobials in Southeast Asian farming systems. Copyright © 2016 Nguyen et al.

Dominant β-catenin mutations cause intellectual disability with recognizable syndromic features

PubMed Central

Tucci, Valter; Kleefstra, Tjitske; Hardy, Andrea; Heise, Ines; Maggi, Silvia; Willemsen, Marjolein H.; Hilton, Helen; Esapa, Chris; Simon, Michelle; Buenavista, Maria-Teresa; McGuffin, Liam J.; Vizor, Lucie; Dodero, Luca; Tsaftaris, Sotirios; Romero, Rosario; Nillesen, Willy N.; Vissers, Lisenka E.L.M.; Kempers, Marlies J.; Vulto-van Silfhout, Anneke T.; Iqbal, Zafar; Orlando, Marta; Maccione, Alessandro; Lassi, Glenda; Farisello, Pasqualina; Contestabile, Andrea; Tinarelli, Federico; Nieus, Thierry; Raimondi, Andrea; Greco, Barbara; Cantatore, Daniela; Gasparini, Laura; Berdondini, Luca; Bifone, Angelo; Gozzi, Alessandro; Wells, Sara; Nolan, Patrick M.

2014-01-01

The recent identification of multiple dominant mutations in the gene encoding β-catenin in both humans and mice has enabled exploration of the molecular and cellular basis of β-catenin function in cognitive impairment. In humans, β-catenin mutations that cause a spectrum of neurodevelopmental disorders have been identified. We identified de novo β-catenin mutations in patients with intellectual disability, carefully characterized their phenotypes, and were able to define a recognizable intellectual disability syndrome. In parallel, characterization of a chemically mutagenized mouse line that displays features similar to those of human patients with β-catenin mutations enabled us to investigate the consequences of β-catenin dysfunction through development and into adulthood. The mouse mutant, designated batface (Bfc), carries a Thr653Lys substitution in the C-terminal armadillo repeat of β-catenin and displayed a reduced affinity for membrane-associated cadherins. In association with this decreased cadherin interaction, we found that the mutation results in decreased intrahemispheric connections, with deficits in dendritic branching, long-term potentiation, and cognitive function. Our study provides in vivo evidence that dominant mutations in β-catenin underlie losses in its adhesion-related functions, which leads to severe consequences, including intellectual disability, childhood hypotonia, progressive spasticity of lower limbs, and abnormal craniofacial features in adults. PMID:24614104

Rigorous, robust and systematic: Qualitative research and its contribution to burn care. An integrative review.

PubMed

Kornhaber, Rachel Anne; de Jong, A E E; McLean, L

2015-12-01

Qualitative methods are progressively being implemented by researchers for exploration within healthcare. However, there has been a longstanding and wide-ranging debate concerning the relative merits of qualitative research within the health care literature. This integrative review aimed to exam the contribution of qualitative research in burns care and subsequent rehabilitation. Studies were identified using an electronic search strategy using the databases PubMed, Cumulative Index of Nursing and Allied Health Literature (CINAHL), Excerpta Medica database (EMBASE) and Scopus of peer reviewed primary research in English between 2009 to April 2014 using Whittemore and Knafl's integrative review method as a guide for analysis. From the 298 papers identified, 26 research papers met the inclusion criteria. Across all studies there was an average of 22 participants involved in each study with a range of 6-53 participants conducted across 12 nations that focussed on burns prevention, paediatric burns, appropriate acquisition and delivery of burns care, pain and psychosocial implications of burns trauma. Careful and rigorous application of qualitative methodologies promotes and enriches the development of burns knowledge. In particular, the key elements in qualitative methodological process and its publication are critical in disseminating credible and methodologically sound qualitative research. Copyright © 2015 Elsevier Ltd and ISBI. All rights reserved.

Utilizing the resource of twins reared apart: their distribution across nine provinces or cities of China.

PubMed

Gao, Wenjing; Zhou, Bin; Cao, Weihua; Lv, Jun; Yu, Canqing; Wang, Shengfeng; Pang, Zengchang; Cong, Liming; Dong, Zhong; Wu, Fan; Wang, Hua; Wu, Xianping; Jiang, Guohong; Wang, Xiaojie; Wang, Binyou; Li, Liming

2015-04-01

Twins reared apart provide a fascinating experiment to distinguish genetic from environmental influences. However, there is as yet no broad report on distribution of twins reared apart, especially in the Chinese population. In this study, information on 18,295 volunteer twin pairs of all age groups was compiled in nine provinces or cities of China, and questionnaires were used for zygosity determination. It was discovered that twins reared apart from 0 to 10 years of age accounted for 2.2% of all twin interviewees, with the proportion of this 0-10 group separated before 1, 2, and 5 years old, accounting for 65.3%, 76.1%, and 91.3%, respectively. The proportion of twins reared apart is not significantly related to zygosity or gender, but it is related to region and twin age. As the age of twins lowers, the proportion of those reared apart gradually decreases. Twins reared apart will become rarer in the future and therefore should be cherished as a resource.

Improvement for enhancing effectiveness of universal power system (UPS) continuous testing process

NASA Astrophysics Data System (ADS)

Sriratana, Lerdlekha

2018-01-01

This experiment aims to enhance the effectiveness of the Universal Power System (UPS) continuous testing process of the Electrical and Electronic Institute by applying work scheduling and time study methods. Initially, the standard time of testing process has not been considered that results of unaccurate testing target and also time wasting has been observed. As monitoring and reducing waste time for improving the efficiency of testing process, Yamazumi chart and job scheduling theory (North West Corner Rule) were applied to develop new work process. After the improvements, the overall efficiency of the process possibly increased from 52.8% to 65.6% or 12.7%. Moreover, the waste time could reduce from 828.3 minutes to 653.6 minutes or 21%, while testing units per batch could increase from 3 to 4 units. Therefore, the number of testing units would increase from 12 units up to 20 units per month that also contribute to increase of net income of UPS testing process by 72%.

Expanding and Adapting the Protean Career Management Scale for University Students (PCMS-U).

PubMed

Liberato Borges, Ludmila F; De Andrade, Alexsandro L; Ziebell de Oliveira, Manoela; Guerra, Valeschka Martins

2015-12-28

Many changes in the socioeconomic scenario led to the emergence of different models of career guidance, among which the protean career stands out. This model works with the prospect of a career that is self-directed and aligned with personal values, with important propositions for both professionals and students entering the work market. In the Brazilian scenario, however, there is a lack of appropriate measures to evaluate protean aspects among college students without work experience. Thus, the present study aimed at adapting and validating the attitudes towards the Protean Career Scale to this population. The sample consisted of 902 students aging from 18 to 30 years old (M = 22.52; SD = 6.53) attending 34 different undergraduate courses. Exploratory and confirmatory analysis attested the two-dimensional nature of the scale structure. The reliability indexes were satisfactory: over .65. The correlation between the protean models and factors such as personality, values, and locus of control provided adequate evidence of the measure's predictive validity (p < .05).

Electronic structure and molecular dynamics of Na2Li

NASA Astrophysics Data System (ADS)

Malcolm, Nathaniel O. J.; McDouall, Joseph J. W.

Following the first report (Mile, B., Sillman, P. D., Yacob, A. R. and Howard, J. A., 1996, J. chem. Soc. Dalton Trans , 653) of the EPR spectrum of the mixed alkali-metal trimer Na2Li a detailed study has been made of the electronic structure and structural dynamics of this species. Two isomeric forms have been found: one of the type, Na-Li-Na, of C , symmetry and another, Li-Na-Na, of C symmetry. Also, there are two linear saddle points which correspond to 'inversion' transition structures, and a saddle point of C symmetry which connects the two minima. A molecular dynamics investigation of these species shows that, at the temperature of the reported experiments (170 K), the C minimum is not 'static', but undergoes quite rapid inversion. At higher temperatures the C minimum converts to the C form, but by a mechanism very different from that suggested by minimum energy path considerations. 2 2v s s 2v 2v s

The Associations Between E-Cigarettes and Binge Drinking, Marijuana Use, and Energy Drinks Mixed With Alcohol.

PubMed

Milicic, Sandra; Leatherdale, Scott T

2017-03-01

Use of e-cigarettes by youth is proliferating worldwide, but little is known about the behavioral profile of youth e-cigarette users and the association of e-cigarette use with other health-risky behaviors. This study examines the associations between e-cigarette use and tobacco, marijuana, and alcohol use among a large sample of Canadian youth. Using Canadian data from 39,837 grade 9 to 12 students who participated in year 3 (2014-2015) of the COMPASS study, logistic regression models were used to examine how current use of e-cigarettes were associated with tobacco, marijuana, binge drinking, and energy drinks mixed with alcohol. Pearson's chi-square tests were used to examine subgroup differences by sex. Overall, 9.75% of respondents were current e-cigarette users. Current cigarette smokers (odds ratio [OR] = 3.009), current marijuana users (OR = 5.549), and noncurrent marijuana users (OR = 3.653) were more likely to report using e-cigarettes than noncigarette smokers and nonmarijuana users. Gender differences among males and females showed higher risk of e-cigarette use among female current marijuana users (OR = 7.029) relative to males (OR = 4.931) and female current smokers (OR = 3.284) compared to males (OR = 2.862). Compared to nonbinge drinkers, weekly (OR = 3.253), monthly (OR = 3.113), and occasional (OR = 2.333) binge drinkers were more likely to use e-cigarettes. Similarly, students who consume energy drinks mixed with alcohol (OR = 1.650) were more likely to use e-cigarettes compared to students who do not consume them. We identify that youth who binge drink or use marijuana have a greater increased risk for using e-cigarettes compared to cigarette smokers. These data suggest that efforts to prevent e-cigarette use should not only be discussed in the domain of tobacco control. Copyright © 2016 Society for Adolescent Health and Medicine. Published by Elsevier Inc. All rights reserved.

Automated culture system experiments hardware: developing test results and design solutions.

PubMed

Freddi, M; Covini, M; Tenconi, C; Ricci, C; Caprioli, M; Cotronei, V

2002-07-01

The experiment proposed by Prof. Ricci University of Milan is funded by ASI with Laben as industrial Prime Contractor. ACS-EH (Automated Culture System-Experiment Hardware) will support the multigenerational experiment on weightlessness with rotifers and nematodes within four Experiment Containers (ECs) located inside the European Modular Cultivation System (EMCS) facility..Actually the Phase B is in progress and a concept design solution has been defined. The most challenging aspects for the design of such hardware are, from biological point of view the provision of an environment which permits animal's survival and to maintain desiccated generations separated and from the technical point of view, the miniaturisation of the hardware itself due to the reduce EC provided volume (160mmx60mmx60mm). The miniaturisation will allow a better use of the available EMCS Facility resources (e.g. volume. power etc.) and to fulfil the experiment requirements. ACS-EH, will be ready to fly in the year 2005 on boar the ISS.

RDT&E Progress and Plansfor Hexavalent Chromium (Cr6+)

DTIC Science & Technology

2011-05-12

RDT&E Progress and Plans for Hexavalent Chromium (Cr6+) Bruce Sartwell Weapons Systems and Platforms Program Manager E2S2 Conference May 12, 2011...2011 2. REPORT TYPE 3. DATES COVERED 00-00-2011 to 00-00-2011 4. TITLE AND SUBTITLE RDT&E Progress and Plansfor Hexavalent Chromium (Cr6+) 5a...Tasks/Projects Surface treatments and soluble inhibitors: 1. Fundamental studies of the Trivalent Chrome Process (TCP) 2. Mechanisms of selected

Using the Pragmatic Progressive Philosophy in Adult Education

ERIC Educational Resources Information Center

Ellis, Marsha L.

2012-01-01

Using a pragmatic approach of progressive philosophy when educating adult learners utilizes the knowledge of history, to connect reality with current experiences through facilitated learning. The purpose of this paper is an attempt to show how adult education that uses a pragmatic progressive philosophy encompasses adult experiences,…

[Epidemiological characteristics of diarrheagenic Escherichia coli among diarrhea outpatients in China, 2012-2015].

PubMed

Zhang, Z K; Lai, S J; Yu, J X; Yang, W Q; Wang, X; Jing, H Q; Li, Z J; Yang, W Z

2017-04-10

Objective: To understand the epidemiological characteristics of diarrheagenic Escherichia (E.) coli (DEC) among diarrhea outpatients in China. Methods: Diarrhea surveillance program was conducted in outpatient and emergency departments from 170 hospitals that under the sentinel programs in 27 provinces, from 2012-2015. Clinical and epidemiological data regarding diarrhea patients were collected, with fecal specimens sampled and tested for DEC in 92 network-connected laboratories. Results: Among all the 46 721 diarrhea cases, 7.7 % of them appeared DEC positive in those with geographic heterogeneity. In 2 982 cases (6.4 % ) with available data on PCR subtypes of DEC, enteroaggregative E. coli (EAEC, 1 205 cases, 40.4 % ) appeared the most commonly seen pathogens, followed by enteropathogenic E. coli (EPEC, 815 cases, 27.3 % ), and enterotoxigenic E.coli (ETEC, 653 cases, 21.9 % ). The highest positive rate of DEC was observed in outpatients of 25-34 years old (10.1 % ), living in the warm temperate zones (11.1 % ), and with mucous-like stool (9.4 % ). The positive rate of DEC showed a strong seasonal pattern, with peaks in summer, for all the subtypes. Conclusions: DEC seemed easy to be detected among diarrhea outpatients in China, with EAEC, EPEC and ETEC the most commonly identified subtypes. Epidemiological characteristics regarding the heterogeneities of DEC appeared different, in regions, age groups and seasons. Long-term surveillance programs should be strengthened to better understand the epidemiology of DEC, in China.

Project 8, Phase III Design: Placing an eV-Scale Limit on the Neutrino Mass using Cyclotron Radiation Emission Spectroscopy

NASA Astrophysics Data System (ADS)

Oblath, Noah; Project 8 Collaboration

2016-09-01

We report on the design concept for Phase III of the Project 8 experiment. In the third phase of Project 8 we aim to place a limit on the neutrino mass that is similar to the current limits set by tritium beta-decay experiments, mν < 2eV . From the first two phases of Project 8 we move to a novel design consisting of a 100cm3 cylindrical volume of tritium gas instrumented with two 30-element rings of inward-facing antennas. Beam-forming techniques similar to those used in radioastronomy will be employed to search for and track electron signals in the fiducial volume. This talk will present the quantitative design concept for the phased-array receiver, and illustrate how we are progressing towards the Phase IV experiment, which will have sensitivity to the neutrino mass scale allowed by the inverted mass hierarchy. This work is supported by the DOE Office of Science Early Career Research Program, and the Laboratory Directed Research and Development Program at Pacific Northwest National Laboratory.

Medical decision-making capacity and its cognitive predictors in progressive MS: Preliminary evidence.

PubMed

Gerstenecker, Adam; Lowry, Kathleen; Myers, Terina; Bashir, Khurram; Triebel, Kristen L; Martin, Roy C; Marson, Daniel C

2017-09-15

Medical decision-making capacity (MDC) refers to the ability to make informed decisions about treatment and declines in cognition are associated with declines in MDC across multiple disease entities. However, although it is well known that cognitive impairment is prevalent in multiple sclerosis (MS), little is known about MDC in the disease. Data from 22 persons with progressive MS and 18 healthy controls were analyzed. All diagnoses were made by a board-certified neurologist with experience in MS. All study participants were administered a vignette-based measure of MDC and also a neuropsychological battery. Performance on three MDC consent standards (i.e., Appreciation, Reasoning, Understanding) was significantly lower for people with progressive MS as compared to healthy controls. In the progressive MS group, verbal fluency was the primary cognitive predictor for both Reasoning and Understanding consent standards. Verbal learning and memory was the primary cognitive predictor for Appreciation. MS severity was not significantly correlated with any MDC variable. MDC is a complex and cognitively mediated functional ability that is impaired in many people with progressive MS. Verbal measures of fluency and memory are strongly associated with MDC performances in the current sample of people with MS and could potentially be utilized to quickly screen for MDC impairment in MS. Copyright © 2017 Elsevier B.V. All rights reserved.

PROSPECT - A Precision Oscillation and Spectrum Experiment

NASA Astrophysics Data System (ADS)

Zhang, Xianyi; Prospect Collaboration

2017-01-01

PROSPECT, the PRecision Oscillation and SPECTrum Experiment, is a multi-phased short baseline reactor antineutrino experiment that aims to precisely measure the U-235 antineutrino spectrum and prob for oscillation effects involving a possible Δm2 1 eV2 scale sterile neutrino. In PROSPECT Phase-I, an optically segmented Li-6 loaded liquid scintillator detector will be deployed at at the baseline of 7-12m from the High Flux Isotope Reactor at the Oak Ridge National Laboratory. PROSPECT will measure the spectrum of U-235 to aid in resolving the unexplained inconsistency between predictive spectral models and recent experimental measurements using LEU cores, while the oscillation measurement will probe the best fit region suggested by global fitting studies within 1-year data taking. This talk will introduce the design of PROSPECT Phase-I, the discovery potential of the experiment, and the progress the collaboration has made toward realizing PROSPECT Phase-I. Department of Energy

Inertial fusion program. Progress report, January 1-June 30, 1978

DOE Office of Scientific and Technical Information (OSTI.GOV)

Skoberne, F.

1980-05-01

Studies and experiments aimed at investigating the possibility of restoring wavefront quality in optical systems through phase conjugation are summarized, and work that could lead to the development of highly damage-resistant isolators is discussed. The effects of various parameters on pulse-energy uniformity and of multipass extraction on laser efficiency are reported. Results of equation-of-state, shock propagation, multiburst simulation, and opacity measurements are discussed. Target designs are described that should provide a smooth transition from the exploding-pusher regime of experiments to that of isentropic compression. Progress in target fabrication techniques toward creating a 20-times-liquid-density target are outlined, and efforts that ledmore » to the extension of our neutron detection capability to levels of less than 10/sup 3/ n are summarized. The results of various studies of laser fusion application, e.g., for producing ultrahigh-temperature process heat or hydrogen from water decomposition are presented, as well as investigations of fusion-fission hybrids for the production of /sup 233/U from /sup 232/Th.« less

Through the eye of the needle: recent advances in understanding biopolymer translocation.

PubMed

Panja, Debabrata; Barkema, Gerard T; Kolomeisky, Anatoly B

2013-10-16

In recent years polymer translocation, i.e., transport of polymeric molecules through nanometer-sized pores and channels embedded in membranes, has witnessed strong advances. It is now possible to observe single-molecule polymer dynamics during the motion through channels with unprecedented spatial and temporal resolution. These striking experimental studies have stimulated many theoretical developments. In this short theory-experiment review, we discuss recent progress in this field with a strong focus on non-equilibrium aspects of polymer dynamics during the translocation process.

Engine-Level Simulation of Liquid Rocket Combustion Instabilities: Transcritical Combustion Simulations in Single Injector Configurations

DTIC Science & Technology

2012-03-01

simple 1-step mechanism taking into account 4 species: CH4, O2, CO2 and H2O. Figure 2. Multiblock grid for the CVRC experiment. Left: Overall view, Right... Supercritical (and subcritical) fluid behavior and modeling: drops, streams, shear and mixing layers, jets and sprays. Progress in Energy and...hydrogen shear-coaxial jet flames at supercritical pressure. Com- bustion science and technology, 178(1-3):229–252, 2006. 12 B. E. Poling, J. M. Prausnitz

Proceedings of the Annual Conference of the Military Testing Association (19th), 17-21 October 1977, San Antonio, Texas

DTIC Science & Technology

1979-11-01

to-?ir kills, especially since we will probably be atle to field only a relatively small number of fighter pilots in future wars. Fighter pilots have...Education and Training, Information, And Legal, too many colonel positlons were allocated. Overall, many jobs wer found to be undergraded, especially at the...t preparing the final eppmntice progress/status report, 4e avy C :-vs educacion specialist will regard previous work experience as distri±xtnd

Role of Protein Synthesis Initiation Factors in Dietary Soy Isoflavone-Mediated Effects on Breast Cancer Progression

DTIC Science & Technology

2014-08-01

experiments of this award and published in the high-impact peer-reviewed journal: Journal of Biological Chemistry (13), was that the described increase...of genistein and other flavonoids in human breast cancer cells in vitro, Nutr Cancer, 27: 31-40, 1997. 13 de la,P.C., Otero-Franqui,E., Martinez...properties of genistein and other flavonoids in human breast cancer cells in vitro, Nutr Cancer, 27: 31-40, 1997. 3 Okabe,Y., Shimazu,T. and Tanimoto,H

Understanding the psychosocial experiences of adults with mild-moderate hearing loss: An application of Leventhal’s self-regulatory model

PubMed Central

Heffernan, Eithne; Coulson, Neil S.; Henshaw, Helen; Barry, Johanna G.; Ferguson, Melanie A

2017-01-01

Objective This study explored the psychosocial experiences of adults with hearing loss using the self-regulatory model as a theoretical framework. The primary components of the model, namely cognitive representations, emotional representations, and coping responses, were examined. Design Individual semi-structured interviews were conducted. The data were analysed using an established thematic analysis procedure. Study sample Twenty-five adults with mild-moderate hearing loss from the UK and nine hearing healthcare professionals from the UK, USA, and Canada were recruited via maximum variation sampling. Results Cognitive representations: Most participants described their hearing loss as having negative connotations and consequences, although they were not particularly concerned about the progression or controllability/curability of the condition. Opinions differed regarding the benefits of understanding the causes of one’s hearing loss in detail. Emotional representations: negative emotions dominated, although some experienced positive emotions or muted emotions. Coping responses: engaged coping (e.g. hearing aids, communication tactics) and disengaged coping (e.g. withdrawal from situations, withdrawal within situations): both had perceived advantages and disadvantages. Conclusions This novel application of the self-regulatory model demonstrates that it can be used to capture the key psychosocial experiences (i.e. perceptions, emotions, and coping responses) of adults with mild-moderate hearing loss within a single, unifying framework. PMID:26754550

29 CFR 6.54 - Hearing.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 29 Labor 1 2013-07-01 2013-07-01 false Hearing. 6.54 Section 6.54 Labor Office of the Secretary of... Length Proceedings § 6.54 Hearing. (a) Except as provided in § 6.53(c) of this title, the hearing shall..., including the presentation of additional evidence, shall be considered at the hearing. There shall be a...

29 CFR 6.54 - Hearing.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 29 Labor 1 2012-07-01 2012-07-01 false Hearing. 6.54 Section 6.54 Labor Office of the Secretary of... Length Proceedings § 6.54 Hearing. (a) Except as provided in § 6.53(c) of this title, the hearing shall..., including the presentation of additional evidence, shall be considered at the hearing. There shall be a...

29 CFR 6.54 - Hearing.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 29 Labor 1 2011-07-01 2011-07-01 false Hearing. 6.54 Section 6.54 Labor Office of the Secretary of... Length Proceedings § 6.54 Hearing. (a) Except as provided in § 6.53(c) of this title, the hearing shall..., including the presentation of additional evidence, shall be considered at the hearing. There shall be a...

Validation of the Chinese Version of the Social Emotional Health Survey-Primary

ERIC Educational Resources Information Center

Wang, Cixin; Yang, Chunyan; Jiang, Xu; Furlong, Michael

2018-01-01

The Social Emotional Health Survey-Primary (SEHS-P) was originally developed to assess U.S. elementary students' positive psychological traits: gratitude, zest, optimism, and persistence, and the higher-order latent construct of covitality. The present study evaluated the validity of a Chinese version of SEHS-P with a sample of 653 Chinese…

20 CFR 653.113 - Processing apparent violations.

Code of Federal Regulations, 2013 CFR

2013-04-01

... employee shall document the suspected violation and refer this information to the local office manager. (b) If the employer has filed a job order with the JS office within the past 12 months, the local office... agency in writing. (c) If the employer has not filed a job order with the local office during the past 12...

20 CFR 653.113 - Processing apparent violations.

Code of Federal Regulations, 2014 CFR

2014-04-01

... employee shall document the suspected violation and refer this information to the local office manager. (b) If the employer has filed a job order with the JS office within the past 12 months, the local office... agency in writing. (c) If the employer has not filed a job order with the local office during the past 12...

20 CFR 653.113 - Processing apparent violations.

Code of Federal Regulations, 2012 CFR

2012-04-01

... employee shall document the suspected violation and refer this information to the local office manager. (b) If the employer has filed a job order with the JS office within the past 12 months, the local office... agency in writing. (c) If the employer has not filed a job order with the local office during the past 12...

20 CFR 653.113 - Processing apparent violations.

Code of Federal Regulations, 2011 CFR

2011-04-01

... employee shall document the suspected violation and refer this information to the local office manager. (b) If the employer has filed a job order with the JS office within the past 12 months, the local office... agency in writing. (c) If the employer has not filed a job order with the local office during the past 12...

40 CFR 65.3 - Compliance with standards and operation and maintenance requirements.

Code of Federal Regulations, 2014 CFR

2014-07-01

...)(4)(i) and (ii) do not apply to Group 2A or Group 2B process vents. Compliance with design, equipment... include, but are not limited to, air pollution control technologies, recovery technologies, work practices... control devices are not required but may be used if available. This paragraph (a)(3) does not apply to...

40 CFR 65.3 - Compliance with standards and operation and maintenance requirements.

Code of Federal Regulations, 2011 CFR

2011-07-01

...)(4)(i) and (ii) do not apply to Group 2A or Group 2B process vents. Compliance with design, equipment... include, but are not limited to, air pollution control technologies, recovery technologies, work practices... control devices are not required but may be used if available. This paragraph (a)(3) does not apply to...

Exploration of Single-Chip Phase-Sensitive Amplifiers

DTIC Science & Technology

2015-11-05

dispersion result of an ITU G.653 single mode fiber. The input wavelength was shifted from 1545 nm to 1575 nm. As we can see from Fig. 14, at 1550 nm...saturate the SOA, the measurement can only covers a wavelength range from 1545 nm to 1575 nm because of the limited gain bandwidth of the EDFA we

49 CFR 1150.7 - Environmental and energy data.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 49 Transportation 8 2014-10-01 2014-10-01 false Environmental and energy data. 1150.7 Section 1150... RAILROAD LINES Applications Under 49 U.S.C. 10901 § 1150.7 Environmental and energy data. As exhibit H... Policy Act of 1969,” 363 I.C.C. 653 (1980), and in accordance with “Implementation of the Energy Policy...

49 CFR 1150.7 - Environmental and energy data.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 49 Transportation 8 2012-10-01 2012-10-01 false Environmental and energy data. 1150.7 Section 1150... RAILROAD LINES Applications Under 49 U.S.C. 10901 § 1150.7 Environmental and energy data. As exhibit H... Policy Act of 1969,” 363 I.C.C. 653 (1980), and in accordance with “Implementation of the Energy Policy...

49 CFR 1150.7 - Environmental and energy data.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 49 Transportation 8 2010-10-01 2010-10-01 false Environmental and energy data. 1150.7 Section 1150... RAILROAD LINES Applications Under 49 U.S.C. 10901 § 1150.7 Environmental and energy data. As exhibit H... Policy Act of 1969,” 363 I.C.C. 653 (1980), and in accordance with “Implementation of the Energy Policy...

49 CFR 1150.7 - Environmental and energy data.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 49 Transportation 8 2011-10-01 2011-10-01 false Environmental and energy data. 1150.7 Section 1150... RAILROAD LINES Applications Under 49 U.S.C. 10901 § 1150.7 Environmental and energy data. As exhibit H... Policy Act of 1969,” 363 I.C.C. 653 (1980), and in accordance with “Implementation of the Energy Policy...

49 CFR 1150.7 - Environmental and energy data.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 49 Transportation 8 2013-10-01 2013-10-01 false Environmental and energy data. 1150.7 Section 1150... RAILROAD LINES Applications Under 49 U.S.C. 10901 § 1150.7 Environmental and energy data. As exhibit H... Policy Act of 1969,” 363 I.C.C. 653 (1980), and in accordance with “Implementation of the Energy Policy...

Psychometric Characteristics of the Korean Version of the Satisfaction with Life Scale Adapted for Children

ERIC Educational Resources Information Center

Lim, Young-Jin

2015-01-01

The aim of this study was to examine the internal consistency reliability, test-retest reliability, factorial structure validity, and convergent validity of a Korean version of the Satisfaction With Life Scale adapted for children (K-SWLS-C). Participants consisted of 653 elementary school students (48% were male). The internal consistency of the…

77 FR 19690 - Notice of Inventory Completion: California Department of Parks and Recreation, Sacramento, CA

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-02

...: California Department of Parks and Recreation, Sacramento, CA AGENCY: National Park Service, Interior. ACTION... Department of Parks and Recreation, 1416 9th Street, Room 902, Sacramento, CA 95814, telephone (916) 653-8893... located in San Diego County, CA. This notice is published as part of the National Park Service's...

Influence of electric field on the hydrogen bond network of water.

PubMed

Suresh, S J; Satish, A V; Choudhary, A

2006-02-21

Understanding the inherent response of water to an external electric (E)-field is useful towards decoupling the role of E-field and surface in several practically encountered situations, such as that near an ion, near a charged surface, or within a biological nanopore. While this problem has been studied in some detail through simulations in the past, it has not been very amenable for theoretical analysis owing to the complexities presented by the hydrogen (H) bond interactions in water. It is also difficult to perform experiments with water in externally imposed, high E-fields owing to dielectric breakdown problems; it is hence all the more important that theoretical progress in this area complements the progress achieved through simulations. In an attempt to fill this lacuna, we develop a theory based on relatively simple concepts of reaction equilibria and Boltzmann distribution. The results are discussed in three parts: one pertaining to a comparison of the key features of the theory vis a vis published simulation/experimental results; second pertaining to insights into the H-bond stoichiometry and molecular orientations at different field strengths and temperatures; and the third relating to a surprising but explainable finding that H-bonds can stabilize molecules whose dipoles are oriented perpendicular to the direction of field (in addition to the E-field and H-bonds both stabilizing molecules with dipoles aligned in the direction of the field).

Progress in Treatment and Experienced and Expressed Anger among Incarcerated Men.

ERIC Educational Resources Information Center

Richards, Henry; Kaplan, Myra; Kafami, Debra M.

2000-01-01

Examines the relationship of anger experience and expression with treatment progress in incarcerated male (N=56) volunteers. As predicted, subjects with greater treatment gains had significantly less anger experience and more anger control than low progress subjects did. These differences were not influenced by deception or impression management.…

Student Experiences of High-Stakes Testing for Progression in One Undergraduate Nursing Program

ERIC Educational Resources Information Center

McClenny, Tammy

2016-01-01

High-stakes testing in undergraduate nursing education are those assessments used to make critical decisions for student progression and graduation. The purpose of this study was to explore the different ways students experience multiple high-stakes tests for progression in one undergraduate BSN program. Research participants were prelicensure…

Reduced progression of atherosclerosis in apolipoprotein E-deficient mice with phenylhydrazine-induced anemia.

PubMed

Paul, A; Calleja, L; Vilella, E; Martínez, R; Osada, J; Joven, J

1999-11-01

Epidemiological and experimental studies suggest that circulating erythrocytes play a role in the incidence of coronary heart disease. We investigated the influence of phenylhydrazine (PHZ)-induced anemia on the formation of atherosclerotic lesions in apo E-deficient mice on regular chow and on a high-fat, high-cholesterol diet during 10 weeks. The repeated doses of PHZ caused sustained anemia throughout the study, changes in the physical characteristics of erythrocytes and increased reticulocyte count. The lesions of the anemic animals were smaller than in the controls and this was even more evident in mice fed with the atherogenic diet. A positive correlation was found between circulating red blood cells at the end of the experiment and the area of aortic lesion. There was also a negative association between the lesion and the reticulocyte count. This reduced progression of atherosclerotic lesions is independent of nutritional status or the lipoprotein cholesterol distribution. The results suggest that mechanisms related to the number of circulating red blood cells may have a significant influence on the development of atherosclerosis.

Dark Searches and γγ Physics at KLOE

NASA Astrophysics Data System (ADS)

Curciarello, Francesca

2017-04-01

The search for a dark sector mediated by a new gauge boson, the dark photon, is motivated by many astrophysical anomalies and by the g - 2 discrepancy. The KLOE experiment, operating at the e+e- DAΦNE collider in Frascati, searched for a visibly-decaying dark photon by investigating the ϕ-Dalitz decay into the η meson, the dark photon production from continuum, and the Higgsstrahlung process. The KLOE-2 run started in November 2014, after the upgrade of both, DAΦNE and the KLOE apparatus. In particular, two high electron and positron tagger stations were installed in the DAΦNE layout to study γγ interactions at 1 GeV. Progress status of the project is given.

Tendency for oxidation of annelid hemoglobin at alkaline pH and dissociated states probed by redox titration.

PubMed

Bispo, Jose Ailton Conceicao; Landini, Gustavo Fraga; Santos, Jose Luis Rocha; Norberto, Douglas Ricardo; Bonafe, Carlos Francisco Sampaio

2005-08-01

The redox titration of extracellular hemoglobin of Glossoscolex paulistus (Annelidea) was investigated in different pH conditions and after dissociation induced by pressure. Oxidation increased with increasing pH, as shown by the reduced amount of ferricyanide necessary for the oxidation of hemoglobin. This behavior was the opposite of that of vertebrate hemoglobins. The potential of half oxidation (E1/2) changed from -65.3 to +146.8 mV when the pH increased from 4.50 to 8.75. The functional properties indicated a reduction in the log P50 from 1.28 to 0.28 in this pH range. The dissociation at alkaline pH or induced by high pressure, confirmed by HPLC gel filtration, suggested that disassembly of the hemoglobin could be involved in the increased potential for oxidation. These results suggest that the high stability and prolonged lifetime common to invertebrate hemoglobins is related to their low tendency to oxidize at acidic pH, in contrast to vertebrate hemoglobins.

Beta reduction factors for protective clothing at the Oak Ridge National Laboratory

DOE Office of Scientific and Technical Information (OSTI.GOV)

Franklin, G.L.; Gonzalez, P.L.

1998-12-31

Beta reduction factors (f{sub {beta}}) for protective clothing (PC) at the Oak Ridge National Laboratory (ORNL) have been determined for a variety of protective clothing combinations. Data was collected to determine the experimental f{sub {beta}} for several combinations of PCs under laboratory conditions. Radiation dose rates were measured with an open window Bicron{reg_sign} RSO-5 ion chamber for two distinct beta energy groups (E{sub max} = 1.218 {times} 10{sup {minus}13} J(0.860 MeV) and 3.653 {times} 10{sup {minus}13} J (2.280 MeV)). Data points determined, as the ratio of unattenuated (no PCs) to attenuated (PCs), were used to derive a set of equationsmore » using the Microsoft{reg_sign} Excel Linet function. Field comparison tests were then conducted to determine the validity of these beta reduction factors. The f{sub {beta}} from the field tests were significantly less than the experimental f{sub {beta}}, indicating that these factors will yield conservative results.« less

Second generation measurement of the electric dipole moment of the electron using trapped ThF+ ions

NASA Astrophysics Data System (ADS)

Ng, Kia Boon; Zhou, Yan; Gresh, Daniel; Cairncross, William; Grau, Matthew; Ni, Yiqi; Ye, Jun; Cornell, Eric

2016-05-01

ThF+ has been chosen as the candidate for a second generation measurement of the electric dipole moment of the electron (eEDM). Compared to the current HfF+ eEDM experiment, ThF+ has several advantages: (i) the eEDM-sensitive state (3Δ1) is the ground state, which facilitates a long coherence time; (ii) its effective electric field (38 GV/cm) is 50% larger than that of HfF+, which promises a direct increase of the eEDM sensitivity; and (iii) the ionization energy of neutral ThF is lower than its dissociation energy, which introduces greater flexibility in rotational state-selective photoionization via core-nonpenetrating Rydberg states. Here, we present progress of our experimental setup, preliminary spectroscopic data of multi-photon ionization, and discussions of new features in ion trapping, state preparation and population readout.

Development of professional expertise in optometry.

PubMed

Faucher, Caroline

2011-04-01

Development of professional expertise is the gradual transition from novice to expert within a profession. Studies on expertise in the profession of optometry have never been published. However, many studies have been performed in other health professions (e.g., nursing, medicine, physical therapy, occupational therapy). This report is an overview of the development of professional expertise that will highlight some applications for optometry. A 5-level scale of professional expertise development, divided into 2 parts, is described. The first part is the progression of students during their professional studies (novice, intermediate, competent). The second part is the professional development occurring during the practice years (advanced, expert). Personal and collective efforts are required to foster the progression toward expertise. Great interest for the profession, motivation, and deliberate practice are individual attitudes that help this progression. The "optometric community of practice," by means of university (professional) training, continuing education, and collaboration between colleagues, also contributes to this process. Professional development is an integral part of the Optometric Oath. Each clinical case is a potential learning experience contributing to one's professional development. Optometrists' attitudes are predominant factors in the progression from one level to another. Copyright © 2011 American Optometric Association. Published by Elsevier Inc. All rights reserved.

Expertise and decision-making in American football

PubMed Central

Woods, Adam J.; Kranjec, Alexander; Lehet, Matt; Chatterjee, Anjan

2015-01-01

In American football, pass interference calls can be difficult to make, especially when the timing of contact between players is ambiguous. American football history contains many examples of controversial pass interference decisions, often with fans, players, and officials interpreting the same event differently. The current study sought to evaluate the influence of experience with concepts important for officiating decisions in American football on the probability (i.e., response criteria) of pass interference calls. We further investigated the extent to which such experience modulates perceptual biases that might influence the interpretation of such events. We hypothesized that observers with less experience with the American football concepts important for pass interference would make progressively more pass interference calls than more experienced observers, even when given an explicit description of the necessary criteria for a pass interference call. In a go/no-go experiment using photographs from American football games, three groups of participants with different levels of experience with American football (Football Naïve, Football Player, and Football Official) made pass interference calls for pictures depicting left-moving and right-moving events. More experience was associated with progressively and significantly fewer pass interference calls [F(2,48) = 10.4, p < 0.001], with Football Naïve participants making the most pass interference calls, and Football Officials the least. In addition, our data replicated a prior finding of spatial biases for interpreting left-moving images more harshly than identical right-moving images, but only in Football Players. These data suggest that experience with the concepts important for making a decision may influence the rate of decision-making, and may also play a role in susceptibility to spatial biases. PMID:26217294

Expertise and decision-making in American football.

PubMed

Woods, Adam J; Kranjec, Alexander; Lehet, Matt; Chatterjee, Anjan

2015-01-01

In American football, pass interference calls can be difficult to make, especially when the timing of contact between players is ambiguous. American football history contains many examples of controversial pass interference decisions, often with fans, players, and officials interpreting the same event differently. The current study sought to evaluate the influence of experience with concepts important for officiating decisions in American football on the probability (i.e., response criteria) of pass interference calls. We further investigated the extent to which such experience modulates perceptual biases that might influence the interpretation of such events. We hypothesized that observers with less experience with the American football concepts important for pass interference would make progressively more pass interference calls than more experienced observers, even when given an explicit description of the necessary criteria for a pass interference call. In a go/no-go experiment using photographs from American football games, three groups of participants with different levels of experience with American football (Football Naïve, Football Player, and Football Official) made pass interference calls for pictures depicting left-moving and right-moving events. More experience was associated with progressively and significantly fewer pass interference calls [F (2,48) = 10.4, p < 0.001], with Football Naïve participants making the most pass interference calls, and Football Officials the least. In addition, our data replicated a prior finding of spatial biases for interpreting left-moving images more harshly than identical right-moving images, but only in Football Players. These data suggest that experience with the concepts important for making a decision may influence the rate of decision-making, and may also play a role in susceptibility to spatial biases.

Impact of the Use of Different Diagnostic Criteria in the Prevalence of Dyslipidemia in Pregnant Women.

PubMed

Feitosa, Alina Coutinho Rodrigues; Barreto, Luciana Tedgue; Silva, Isabela Matos da; Silva, Felipe Freire da; Feitosa, Gilson Soares

2017-07-01

There is a physiologic elevation of total cholesterol (TC) and triglycerides (TG) during pregnancy. Some authors define dyslipidemia (DLP) in pregnant women when TC, LDL and TG concentrations are above the 95th percentile (p95%) and HDL concentration is below the 5th percentile (P5%) for gestational age (GA). To compare the prevalence of DLP in pregnant women using percentiles criteria with the V Brazilian Guidelines on Dyslipidemia and the association with maternal and fetal outcomes. Pregnant women with high-risk conditions, aged 18-50 years, and at least one lipid profile during pregnancy was classified as the presence of DLP by two diagnostic criteria. Clinical and laboratorial data of mothers and newborns were evaluated. 433 pregnant women aged 32.9 ± 6.5 years were studied. Most (54.6%) had lipid profile collected during third trimester. The prevalence of any lipid abnormalities according to the criteria of the National Guidelines was 83.8%: TC ≥ 200 mg/dL was found in 49.9%; LDL ≥ 160 mg/dL, in 14.3%, HDL ≤ 50 mg/dL in 44.4% and TG ≥ 150 mg/dL in 65.3%. Any changes of lipid according to percentiles criteria was found in 19.6%: elevation above the P95% for TC was found in 0.7%; for LDL, 1.7%; for TG 6.4% and HDL lower than the P5% in 13%. The frequency of comorbidity: hypertension, diabetes, smoking, obesity and preeclampsia was similar among pregnant women when DLP was compared by both criteria. The prevalence of DLP during pregnancy varies significantly depending on the criteria used, however none demonstrated superiority in association with comorbidities. Durante a gestação ocorrem, fisiologicamente, elevações do colesterol total (CT) e triglicerídios (TG). Alguns autores definem dislipidemia (DLP) gestacional quando as concentrações de CT, LDL e TG são superiores ao percentil 95 (P95%) e de HDL, inferiores ao percentil 5 (P5%) para a idade gestacional. Comparar a prevalência da DLP em gestantes conforme critério por percentis com o da V Diretriz Brasileira de Dislipidemia e avaliar a associação com desfechos materno-fetais. Gestantes com patologias de alto risco, idade entre 18 a 50 anos, e, pelo menos um perfil lipídico durante a gestação foram classificadas quanto à presença de DLP por dois critérios. Dados clínicos e laboratoriais das mães e neonatos foram avaliados. Estudou-se 433 gestantes com idade de 32,9 ± 6,5 anos. A maioria (54,6%) teve o perfil lipídico coletado no terceiro trimestre. A prevalência de quaisquer das alterações lipídicas, conforme os critérios da Diretriz Nacional, foi de 83,8%: CT ≥ 200 mg/dL foi encontrado em 49,9%; LDL ≥ 160 mg/dL, em 14,3%, HDL ≤ 50 mg/dL em 44,4% e TG ≥ 150 mg/dL, em 65,3%. Quaisquer das alterações lipídicas pelo critério dos percentis foi encontrada em 19,6%: sendo que elevação superior ao P95% para CT foi encontrada em 0,7%; para LDL, em 1,7%; para TG, em 6,4% e inferiores ao P5% para o HDL em 13%. A frequência das comorbidades: hipertensão, diabetes, tabagismo, obesidade e pré-eclâmpsia foi semelhante entre as gestantes quando se comparou DLP pelos dois critérios. A prevalência de DLP na gestação variou significativamente conforme o critério utilizado, entretanto nenhum demonstrou superioridade na associação com comorbidades.

Baseline Kidney Function as Predictor of Mortality and Kidney Disease Progression in HIV-Positive Patients

PubMed Central

Ibrahim, Fowzia; Hamzah, Lisa; Jones, Rachael; Nitsch, Dorothea; Sabin, Caroline; Post, Frank A.

2012-01-01

Background Chronic kidney disease (CKD) is associated with increased all-cause mortality and kidney disease progression. Decreased kidney function at baseline may identify human immunodeficiency virus (HIV)-positive patients at increased risk of death and kidney disease progression. Study Design Observational cohort study. Setting & Participants 7 large HIV cohorts in the United Kingdom with kidney function data available for 20,132 patients. Predictor Baseline estimated glomerular filtration rate (eGFR). Outcomes Death and progression to stages 4-5 CKD (eGFR <30 mL/min/1.73 m2 for >3 months) in Cox proportional hazards and competing-risk regression models. Results Median age at baseline was 34 (25th-75th percentile, 30-40) years, median CD4 cell count was 350 (25th-75th percentile, 208-520) cells/μL, and median eGFR was 100 (25th-75th percentile, 87-112) mL/min/1.73 m2. Patients were followed up for a median of 5.3 (25th-75th percentile, 2.0-8.9) years, during which 1,820 died and 56 progressed to stages 4-5 CKD. A U-shaped relationship between baseline eGFR and mortality was observed. After adjustment for potential confounders, eGFRs <45 and >105 mL/min/1.73 m2 remained associated significantly with increased risk of death. Baseline eGFR <90 mL/min/1.73 m2 was associated with increased risk of kidney disease progression, with the highest incidence rates of stages 4-5 CKD (>3 events/100 person-years) observed in black patients with eGFR of 30-59 mL/min/1.73 m2 and those of white/other ethnicity with eGFR of 30-44 mL/min/1.73 m2. Limitations The relatively small numbers of patients with decreased eGFR at baseline and low rates of progression to stages 4-5 CKD and lack of data for diabetes, hypertension, and proteinuria. Conclusions Although stages 4-5 CKD were uncommon in this cohort, baseline eGFR allowed the identification of patients at increased risk of death and at greatest risk of kidney disease progression. PMID:22521282

Reduced model prediction of electron temperature profiles in microtearing-dominated National Spherical Torus eXperiment plasmas

NASA Astrophysics Data System (ADS)

Kaye, S. M.; Guttenfelder, W.; Bell, R. E.; Gerhardt, S. P.; LeBlanc, B. P.; Maingi, R.

2014-08-01

A representative H-mode discharge from the National Spherical Torus eXperiment is studied in detail to utilize it as a basis for a time-evolving prediction of the electron temperature profile using an appropriate reduced transport model. The time evolution of characteristic plasma variables such as β e , νe ∗ , the MHD α parameter, and the gradient scale lengths of Te, Ti, and ne were examined as a prelude to performing linear gyrokinetic calculations to determine the fastest growing micro instability at various times and locations throughout the discharge. The inferences from the parameter evolutions and the linear stability calculations were consistent. Early in the discharge, when βe and νe ∗ were relatively low, ballooning parity modes were dominant. As time progressed and both βe and νe ∗ increased, microtearing became the dominant low-kθ mode, especially in the outer half of the plasma. There are instances in time and radius, however, where other modes, at higher-kθ, may, in addition to microtearing, be important for driving electron transport. Given these results, the Rebut-Lallia-Watkins (RLW) electron thermal diffusivity model, which is based on microtearing-induced transport, was used to predict the time-evolving electron temperature across most of the profile. The results indicate that RLW does a good job of predicting Te for times and locations where microtearing was determined to be important, but not as well when microtearing was predicted to be stable or subdominant.

Formaldehyde and acetaldehyde emissions from residential wood combustion in Portugal

NASA Astrophysics Data System (ADS)

Cerqueira, Mário; Gomes, Luís; Tarelho, Luís; Pio, Casimiro

2013-06-01

A series of experiments were conducted to characterize formaldehyde and acetaldehyde emissions from residential combustion of common wood species growing in Portugal. Five types of wood were investigated: maritime pine (Pinus pinaster), eucalyptus (Eucalyptus globulus), cork oak (Quercus suber), holm oak (Quercus rotundifolia) and pyrenean oak (Quercus pyrenaica). Laboratory experiments were performed with a typical wood stove used for domestic heating in Portugal and operating under realistic home conditions. Aldehydes were sampled from diluted combustion flue gas using silica cartridges coated with 2,4-dinitrophenylhydrazine and analyzed by high performance liquid chromatography with diode array detection. The average formaldehyde to acetaldehyde concentration ratio (molar basis) in the stove flue gas was in the range of 2.1-2.9. Among the tested wood types, pyrenean oak produced the highest emissions for both formaldehyde and acetaldehyde: 1772 ± 649 and 1110 ± 454 mg kg-1 biomass burned (dry basis), respectively. By contrast, maritime pine produced the lowest emissions: 653 ± 151 and 371 ± 162 mg kg-1 biomass (dry basis) burned, respectively. Aldehydes were sampled separately during distinct periods of the holm oak wood combustion cycles. Significant variations in the flue gas concentrations were found, with higher values measured during the devolatilization stage than in the flaming and smoldering stages.

Relationship Between Adverse Childhood Experiences and Homelessness and the Impact of Axis I and II Disorders

PubMed Central

Roos, Leslie E.; Mota, Natalie; Afifi, Tracie O.; Katz, Laurence Y.; Distasio, Jino

2013-01-01

Objectives. We investigated the links between homelessness associated with serious mental and physical healthy disparities and adverse childhood experiences (ACEs) in nationally representative data, with Axis I and II disorders as potential mediators. Methods. We examined data from the National Epidemiologic Survey of Alcohol and Related Conditions in 2001–2002 and 2004–2005, and included 34 653 participants representative of the noninstitutionalized US population who were 20 years old or older. We studied the variables related to 4 classes of Axis I disorders, all 10 Axis II personality disorders, a wide range of ACEs, and a lifetime history of homelessness. Results. Analyses revealed high prevalences of each ACE in individuals experiencing lifetime homelessness (17%–60%). A mediation model with Axis I and II disorders determined that childhood adversities were significantly related to homelessness through direct effects (adjusted odd ratios = 2.04, 4.24) and indirect effects, indicating partial mediation. Population attributable fractions were also reported. Conclusions. Although Axis I and II disorders partially mediated the relationship between ACEs and homelessness, a strong direct association remained. This novel finding has implications for interventions and policy. Additional research is needed to understand relevant causal pathways. PMID:24148049

Bioprocess optimization for production of thermoalkali-stable protease from Bacillus subtilis K-1 under solid-state fermentation.

PubMed

Singh, Satbir; Bajaj, Bijender Kumar

2016-10-02

Cost-effective production of proteases, which are robust enough to function under harsh process conditions, is always sought after due to their wide industrial application spectra. Solid-state production of enzymes using agro-industrial wastes as substrates is an environment-friendly approach, and it has several advantages such as high productivity, cost-effectiveness, being less labor-intensive, and less effluent production, among others. In the current study, different agro-wastes were employed for thermoalkali-stable protease production from Bacillus subtilis K-1 under solid-state fermentation. Agricultural residues such as cotton seed cake supported maximum protease production (728 U ml(-1)), which was followed by gram husk (714 U ml(-1)), mustard cake (680 U ml(-1)), and soybean meal (653 U ml(-1)). Plackett-Burman design of experiment showed that peptone, moisture content, temperature, phosphates, and inoculum size were the significant variables that influenced the protease production. Furthermore, statistical optimization of three variables, namely peptone, moisture content, and incubation temperature, by response surface methodology resulted in 40% enhanced protease production as compared to that under unoptimized conditions (from initial 728 to 1020 U ml(-1)). Thus, solid-state fermentation coupled with design of experiment tools represents a cost-effective strategy for production of industrial enzymes.

Responses to discrimination and psychiatric disorders among Black, Hispanic, female, and lesbian, gay, and bisexual individuals.

PubMed

McLaughlin, Katie A; Hatzenbuehler, Mark L; Keyes, Katherine M

2010-08-01

We examined associations between perceived discrimination due to race/ethnicity, sexual orientation, or gender; responses to discrimination experiences; and psychiatric disorders. The sample included respondents in the 2004-2005 National Epidemiologic Survey on Alcohol and Related Conditions (n = 34 653). We analyzed the associations between self-reported past-year discrimination and past-year psychiatric disorders as assessed with structured diagnostic interviews among Black (n = 6587); Hispanic (n = 6359); lesbian, gay, and bisexual (LGB; n = 577); and female (n = 20 089) respondents. Black respondents reported the highest levels of past-year discrimination, followed by LGB, Hispanic, and female respondents. Across groups, discrimination was associated with 12-month mood (odds ratio [ORs] = 2.1-3.1), anxiety (ORs = 1.8-3.3), and substance use (ORs = 1.6-3.5) disorders. Respondents who reported not accepting discrimination and not discussing it with others had higher odds of psychiatric disorders (ORs = 2.9-3.9) than did those who did not accept discrimination but did discuss it with others. Black respondents and women who accepted discrimination and did not talk about it with others had elevated rates of mood and anxiety disorders, respectively. Psychiatric disorders are more prevalent among individuals reporting past-year discrimination experiences. Certain responses to discrimination, particularly not disclosing it, are associated with psychiatric morbidity.

Immediate Postsession Feeding Reduces Operant Responding in Rats

ERIC Educational Resources Information Center

Smethells, John R.; Fox, Andrew T.; Andrews, Jennifer J.; Reilly, Mark P.

2012-01-01

Three experiments investigated the effects of immediate and delayed postsession feeding on progressive-ratio and variable-interval schedule performance in rats. During Experiments 1 and 2, immediate postsession feeding decreased the breakpoint, or largest completed ratio, under progressive-ratio schedules. Experiment 3 was conducted to extend the…