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Sample records for experimental background due

  1. Experimental background due to particle induced gas desorption in RHIC

    SciTech Connect

    Zhang,S.Y.; Trbojevic, D.

    2008-08-10

    Beam-gas collision created experimental background, i.e., singles, has affected heavy ion and polarized proton operations in Relativistic Heavy Ion Collider at Brookhaven National Laboratory. The gas molecules in interaction region are mainly caused by the electron induced gas desorption. and the electrons are produced from the beam induced electron multipacting, or called electron cloud. The background has a dependence on the usual electron cloud related parameters, such as the bunch intensity, bunch spacing, and the solenoid field. With the RHIC upgrade plan, the experimental background may become a luminosity limiting factor. Mitigations are discussed.

  2. Light incoherence due to background space fluctuations

    NASA Astrophysics Data System (ADS)

    Maziashvili, Michael

    2016-12-01

    Working by analogy, we use the description of light fluctuations due to random collisions of the radiating atoms to figure out why the reduction of the coherence for light propagating a cosmological distance in the fluctuating background space is negligibly small to be observed by the stellar interferometry.

  3. Background estimation in experimental spectra

    SciTech Connect

    Fischer, R.; Hanson, K. M.; Dose, V.; Linden, W. von der

    2000-02-01

    A general probabilistic technique for estimating background contributions to measured spectra is presented. A Bayesian model is used to capture the defining characteristics of the problem, namely, that the background is smoother than the signal. The signal is allowed to have positive and/or negative components. The background is represented in terms of a cubic spline basis. A variable degree of smoothness of the background is attained by allowing the number of knots and the knot positions to be adaptively chosen on the basis of the data. The fully Bayesian approach taken provides a natural way to handle knot adaptivity and allows uncertainties in the background to be estimated. Our technique is demonstrated on a particle induced x-ray emission spectrum from a geological sample and an Auger spectrum from iron, which contains signals with both positive and negative components. (c) 2000 The American Physical Society.

  4. Experimental limits of the extreme ultraviolet background

    NASA Technical Reports Server (NTRS)

    Wulf-Mathies, C.; Grewing, M.; Kraemer, G.; Schulz-Luepertz, E.; Kimble, R.; Bixler, J.; Bowyer, S.

    1983-01-01

    Photometric observations of the diffuse extreme ultraviolet background with two photometers having bandpasses of 750-940 A and 1040-1080 A are reported. The payload, which was flown aboard an ARIES sounding rocket in June 1982, is described, including the electron detectors, filters, and calibration. The operation of the probe during the experiment, including its motions, are described. The primary experiment involved spectroscopic observation of the hot white dwarf HZ43. The photometer count rate is shown and the measurements of the diffuse background are compared with theoretical predictions. Despite the lower limits obtained using a narrowband detector, the measurements are not sensitive enough to draw any relevant astrophysical conclusions.

  5. Alternatives to animal experimentation: The regulatory background

    SciTech Connect

    Garthoff, Bernward . E-mail: bernward.garthoff@bayercropscience.com

    2005-09-01

    The framework, in which alternatives to animal experiments can be developed, standardized, respectively formally validated, has to be seen in a global context. The ever increasing demand of testing for hazard and risk assessment in health and environment, exemplified by the EU REACH program, subsequently triggers laboratory animal testing. This holds especially true, if no valid alternative methods agreed to by the regulatory authorities and the scientific community are available. At least for regulatory toxicity testing, the global frame and network are given by institutions such as OECD, ICH, and alike. However, due to the necessity of global consent of states, organizations, and stakeholders, the time gap between availability of a novel alternative test method and its final acceptance by authorities and implementation thereafter is widening. The lack of new technologies or opportunities for alternative method application such as, for example, the broad use of transgenic animals for refinement of existing tests, adds to the problem. The bare existence of certain in vivo tests increases also the gap between public demands for testing versus availability of alternative tests. Industries operating on a worldwide basis support the alternative test development in their respective area of research and operational business. However, a more coordinating approach such as that of the ecopa-organization (European Consensus Platform on Alternatives) is needed to exploit the existing possibilities within the current regulatory framework. This will speed up the process of acceptance and challenge the political worldto feel responsible for the sequels of their demanding more testing, that is, by funding alternative method development in academia and industry.

  6. Alternatives to animal experimentation: the regulatory background.

    PubMed

    Garthoff, Bernward

    2005-09-01

    The framework, in which alternatives to animal experiments can be developed, standardized, respectively formally validated, has to be seen in a global context. The ever increasing demand of testing for hazard and risk assessment in health and environment, exemplified by the EU REACH program, subsequently triggers laboratory animal testing. This holds especially true, if no valid alternative methods agreed to by the regulatory authorities and the scientific community are available. At least for regulatory toxicity testing, the global frame and network are given by institutions such as OECD, ICH, and alike. However, due to the necessity of global consent of states, organizations, and stakeholders, the time gap between availability of a novel alternative test method and its final acceptance by authorities and implementation thereafter is widening. The lack of new technologies or opportunities for alternative method application such as, for example, the broad use of transgenic animals for refinement of existing tests, adds to the problem. The bare existence of certain in vivo tests increases also the gap between public demands for testing versus availability of alternative tests. Industries operating on a worldwide basis support the alternative test development in their respective area of research and operational business. However, a more coordinating approach such as that of the ecopa-organization (European Consensus Platform on Alternatives) is needed to exploit the existing possibilities within the current regulatory framework. This will speed up the process of acceptance and challenge the political world to feel responsible for the sequels of their demanding more testing, that is, by funding alternative method development in academia and industry.

  7. Secret loss of unitarity due to the classical background

    NASA Astrophysics Data System (ADS)

    Yang, I.-Sheng

    2017-07-01

    We show that a quantum subsystem can become significantly entangled with a classical background through a process with few or no semiclassical backreactions. We study two quantum harmonic oscillators coupled to each other in a time-independent Hamiltonian. We compare it to its semiclassical approximation in which one of the oscillators is treated as the classical background. In this approximation, the remaining quantum oscillator has an effective Hamiltonian which is time-dependent, and its evolution appears to be unitary. However, in the fully quantum model, the two oscillators can entangle each other. Thus, the unitarity of either individual oscillator is never guaranteed. We derive the critical time scale after which the unitarity of either individual oscillator is irrevocably lost. In particular, we give an example that in the adiabatic limit, unitarity is lost before other relevant questions can be addressed.

  8. Effects of genetic background on response to selection in experimental populations of Arabidopsis thaliana.

    PubMed Central

    Ungerer, Mark C; Linder, C Randal; Rieseberg, Loren H

    2003-01-01

    The extent to which genetic background can influence allelic fitness is poorly understood, despite having important evolutionary consequences. Using experimental populations of Arabidopsis thaliana and map-based population genetic data, we examined a multigeneration response to selection in populations with differentiated genetic backgrounds. Replicated experimental populations of A. thaliana with genetic backgrounds derived from ecotypes Landsberg and Niederzenz were subjected to strong viability and fertility selection by growing individuals from each population at high density for three generations in a growth chamber. Patterns of genome-wide selection were evaluated by examining deviations from expected frequencies of mapped molecular markers. Estimates of selection coefficients for individual genomic regions ranged from near 0 to 0.685. Genomic regions demonstrating the strongest response to selection most often were selected similarly in both genetic backgrounds. The selection response of several weakly selected regions, however, appeared to be sensitive to genetic background, but only one region showed evidence of positive selection in one background and negative selection in another. These results are most consistent with models of adaptive evolution in which allelic fitnesses are not strongly influenced by genetic background and only infrequently change in sign due to variation at other loci. PMID:12586715

  9. Stochastic Gravitational-Wave Background due to Primordial Binary Black Hole Mergers.

    PubMed

    Mandic, Vuk; Bird, Simeon; Cholis, Ilias

    2016-11-11

    Recent Advanced LIGO detections of binary black hole mergers have prompted multiple studies investigating the possibility that the heavy GW150914 binary system was of primordial origin, and hence could be evidence for dark matter in the form of black holes. We compute the stochastic background arising from the incoherent superposition of such primordial binary black hole systems in the Universe and compare it to the similar background spectrum due to binary black hole systems of stellar origin. We investigate the possibility of detecting this background with future gravitational-wave detectors, and conclude that constraining the dark matter component in the form of black holes using stochastic gravitational-wave background measurements will be very challenging.

  10. Stochastic Gravitational-Wave Background due to Primordial Binary Black Hole Mergers

    NASA Astrophysics Data System (ADS)

    Mandic, Vuk; Bird, Simeon; Cholis, Ilias

    2016-11-01

    Recent Advanced LIGO detections of binary black hole mergers have prompted multiple studies investigating the possibility that the heavy GW150914 binary system was of primordial origin, and hence could be evidence for dark matter in the form of black holes. We compute the stochastic background arising from the incoherent superposition of such primordial binary black hole systems in the Universe and compare it to the similar background spectrum due to binary black hole systems of stellar origin. We investigate the possibility of detecting this background with future gravitational-wave detectors, and conclude that constraining the dark matter component in the form of black holes using stochastic gravitational-wave background measurements will be very challenging.

  11. The advantage of positive text-background polarity is due to high display luminance.

    PubMed

    Buchner, Axel; Mayr, Susanne; Brandt, Martin

    2009-07-01

    Reading text from computer screens is better when text is printed in dark letters on light background (positive polarity) than when it is printed in light letters on dark background (negative polarity). An experiment is presented that tests whether this positive polarity advantage is due to the fact that overall display luminance is typically higher for positive than for negative polarity displays. To this end, text-background polarity and display luminance were manipulated independently. No positive polarity advantage was observed when overall display luminance of positive and negative polarity displays was equivalent. There was only an effect of display luminance, with better performance for the higher-luminance displays. This suggests that the positive polarity advantage is in fact due to the typically higher luminance of positive polarity displays. Readability of text presented on computer screens (e.g. on websites) is better when the overall display luminance level is high, as in positive polarity displays (dark letters on light background). Display polarity per se does not affect readability.

  12. Measurements of Plasma Expansion due to Background Gas in the Electron Diffusion Gauge Experiment

    SciTech Connect

    Kyle A. Morrison; Stephen F. Paul; Ronald C. Davidson

    2003-08-11

    The expansion of pure electron plasmas due to collisions with background neutral gas atoms in the Electron Diffusion Gauge (EDG) experiment device is observed. Measurements of plasma expansion with the new, phosphor-screen density diagnostic suggest that the expansion rates measured previously were observed during the plasma's relaxation to quasi-thermal-equilibrium, making it even more remarkable that they scale classically with pressure. Measurements of the on-axis, parallel plasma temperature evolution support the conclusion.

  13. ULF electromagnetic noise due to random variations of background atmospheric current and conductivity

    NASA Astrophysics Data System (ADS)

    Surkov, V. V.; Hayakawa, M.

    2007-06-01

    A mechanism of ULF electromagnetic noise generation due to random fluctuations of the atmospheric conductivity and background currents was examined. Current fluctuations similar to 1/f noise, or flicker noise, are assumed to develop inside large-scale atmospheric inhomogeneities such as thunderstorms, hurricanes, mesoscale convective systems, etc. The random current fields are assumed to be steady, uniform, and isotropic inside the inhomogeneity, which, in turn, implies that the spectral density of the process is delta correlated. A correlation radius of the random process is supposed to be dependent on gas transfer and on the acoustic wave propagation due to pressure and temperature gradients in the atmosphere. To relate the electromagnetic spectra with current fields, a transfer matrix was found, and then the correlation matrix and power spectra of the random electromagnetic field were calculated. It was shown that the large-scale random fluctuations of the atmospheric background current are capable of sustaining generation of the ULF magnetic noise that can be detected on the ground. The spectral index of magnetic noise was found to be 1.5, which is consistent with observation in the 10-2 to 10-4 Hz frequency range.

  14. SPATIAL DAMPING OF PROPAGATING KINK WAVES DUE TO RESONANT ABSORPTION: EFFECT OF BACKGROUND FLOW

    SciTech Connect

    Soler, R.; Goossens, M.; Terradas, J.

    2011-06-20

    Observations show the ubiquitous presence of propagating magnetohydrodynamic (MHD) kink waves in the solar atmosphere. Waves and flows are often observed simultaneously. Due to plasma inhomogeneity in the direction perpendicular to the magnetic field, kink waves are spatially damped by resonant absorption. The presence of flow may affect the wave spatial damping. Here, we investigate the effect of longitudinal background flow on the propagation and spatial damping of resonant kink waves in transversely nonuniform magnetic flux tubes. We combine approximate analytical theory with numerical investigation. The analytical theory uses the thin tube (TT) and thin boundary (TB) approximations to obtain expressions for the wavelength and the damping length. Numerically, we verify the previously obtained analytical expressions by means of the full solution of the resistive MHD eigenvalue problem beyond the TT and TB approximations. We find that the backward and forward propagating waves have different wavelengths and are damped on length scales that are inversely proportional to the frequency as in the static case. However, the factor of proportionality depends on the characteristics of the flow, so that the damping length differs from its static analog. For slow, sub-Alfvenic flows the backward propagating wave gets damped on a shorter length scale than in the absence of flow, while for the forward propagating wave the damping length is longer. The different properties of the waves depending on their direction of propagation with respect to the background flow may be detected by the observations and may be relevant for seismological applications.

  15. Respiratory rate detection algorithm based on RGB-D camera: theoretical background and experimental results.

    PubMed

    Benetazzo, Flavia; Freddi, Alessandro; Monteriù, Andrea; Longhi, Sauro

    2014-09-01

    Both the theoretical background and the experimental results of an algorithm developed to perform human respiratory rate measurements without any physical contact are presented. Based on depth image sensing techniques, the respiratory rate is derived by measuring morphological changes of the chest wall. The algorithm identifies the human chest, computes its distance from the camera and compares this value with the instantaneous distance, discerning if it is due to the respiratory act or due to a limited movement of the person being monitored. To experimentally validate the proposed algorithm, the respiratory rate measurements coming from a spirometer were taken as a benchmark and compared with those estimated by the algorithm. Five tests were performed, with five different persons sat in front of the camera. The first test aimed to choose the suitable sampling frequency. The second test was conducted to compare the performances of the proposed system with respect to the gold standard in ideal conditions of light, orientation and clothing. The third, fourth and fifth tests evaluated the algorithm performances under different operating conditions. The experimental results showed that the system can correctly measure the respiratory rate, and it is a viable alternative to monitor the respiratory activity of a person without using invasive sensors.

  16. Respiratory rate detection algorithm based on RGB-D camera: theoretical background and experimental results

    PubMed Central

    Freddi, Alessandro; Monteriù, Andrea; Longhi, Sauro

    2014-01-01

    Both the theoretical background and the experimental results of an algorithm developed to perform human respiratory rate measurements without any physical contact are presented. Based on depth image sensing techniques, the respiratory rate is derived by measuring morphological changes of the chest wall. The algorithm identifies the human chest, computes its distance from the camera and compares this value with the instantaneous distance, discerning if it is due to the respiratory act or due to a limited movement of the person being monitored. To experimentally validate the proposed algorithm, the respiratory rate measurements coming from a spirometer were taken as a benchmark and compared with those estimated by the algorithm. Five tests were performed, with five different persons sat in front of the camera. The first test aimed to choose the suitable sampling frequency. The second test was conducted to compare the performances of the proposed system with respect to the gold standard in ideal conditions of light, orientation and clothing. The third, fourth and fifth tests evaluated the algorithm performances under different operating conditions. The experimental results showed that the system can correctly measure the respiratory rate, and it is a viable alternative to monitor the respiratory activity of a person without using invasive sensors. PMID:26609383

  17. Detection of enhancement in number densities of background galaxies due to magnification by massive galaxy clusters

    NASA Astrophysics Data System (ADS)

    Chiu, I.; Dietrich, J. P.; Mohr, J.; Applegate, D. E.; Benson, B. A.; Bleem, L. E.; Bayliss, M. B.; Bocquet, S.; Carlstrom, J. E.; Capasso, R.; Desai, S.; Gangkofner, C.; Gonzalez, A. H.; Gupta, N.; Hennig, C.; Hoekstra, H.; von der Linden, A.; Liu, J.; McDonald, M.; Reichardt, C. L.; Saro, A.; Schrabback, T.; Strazzullo, V.; Stubbs, C. W.; Zenteno, A.

    2016-04-01

    We present a detection of the enhancement in the number densities of background galaxies induced from lensing magnification and use it to test the Sunyaev-Zel'dovich effect (SZE-) inferred masses in a sample of 19 galaxy clusters with median redshift z ≃ 0.42 selected from the South Pole Telescope SPT-SZ survey. These clusters are observed by the Megacam on the Magellan Clay Telescope though gri filters. Two background galaxy populations are selected for this study through their photometric colours; they have median redshifts zmedian ≃ 0.9 (low-z background) and zmedian ≃ 1.8 (high-z background). Stacking these populations, we detect the magnification bias effect at 3.3σ and 1.3σ for the low- and high-z backgrounds, respectively. We fit Navarro, Frenk and White models simultaneously to all observed magnification bias profiles to estimate the multiplicative factor η that describes the ratio of the weak lensing mass to the mass inferred from the SZE observable-mass relation. We further quantify systematic uncertainties in η resulting from the photometric noise and bias, the cluster galaxy contamination and the estimations of the background properties. The resulting η for the combined background populations with 1σ uncertainties is 0.83 ± 0.24(stat) ± 0.074(sys), indicating good consistency between the lensing and the SZE-inferred masses. We use our best-fitting η to predict the weak lensing shear profiles and compare these predictions with observations, showing agreement between the magnification and shear mass constraints. This work demonstrates the promise of using the magnification as a complementary method to estimate cluster masses in large surveys.

  18. Detection of Enhancement in Number Densities of Background Galaxies due to Magnification by Massive Galaxy Clusters

    SciTech Connect

    Chiu, I.; Dietrich, J. P.; Mohr, J. J.; Applegate, D. E.; Benson, B. A.; Bleem, L. E.; Bayliss, M. B.; Bocquet, S.; Carlstrom, J. E.; Capasso, R.

    2016-04-11

    We present a detection of the enhancement in the number densities of background galaxies induced from lensing magnification and use it to test the Sunyaev-Zel'dovich effect (SZE-) inferred masses in a sample of 19 galaxy clusters with median redshift z similar or equal to 0.42 selected from the South Pole Telescope SPT-SZ survey. These clusters are observed by the Megacam on the Magellan Clay Telescope though gri filters. Two background galaxy populations are selected for this study through their photometric colours; they have median redshifts zmedian similar or equal to 0.9 (low-z background) and z(median) similar or equal to 1.8 (high-z background). Stacking these populations, we detect the magnification bias effect at 3.3 sigma and 1.3 sigma for the low-and high-z backgrounds, respectively. We fit Navarro, Frenk and White models simultaneously to all observed magnification bias profiles to estimate the multiplicative factor. that describes the ratio of the weak lensing mass to the mass inferred from the SZE observable-mass relation. We further quantify systematic uncertainties in. resulting from the photometric noise and bias, the cluster galaxy contamination and the estimations of the background properties. The resulting. for the combined background populations with 1 sigma uncertainties is 0.83 +/- 0.24(stat) +/- 0.074(sys), indicating good consistency between the lensing and the SZE-inferred masses. We use our best-fitting eta to predict the weak lensing shear profiles and compare these predictions with observations, showing agreement between the magnification and shear mass constraints. This work demonstrates the promise of using the magnification as a complementary method to estimate cluster masses in large surveys.

  19. Detection of enhancement in number densities of background galaxies due to magnification by massive galaxy clusters

    SciTech Connect

    Chiu, I.; Dietrich, J. P.; Mohr, J.; Applegate, D. E.; Benson, B. A.; Bleem, L. E.; Bayliss, M. B.; Bocquet, S.; Carlstrom, J. E.; Capasso, R.; Desai, S.; Gangkofner, C.; Gonzalez, A. H.; Gupta, N.; Hennig, C.; Hoekstra, H.; von der Linden, A.; Liu, J.; McDonald, M.; Reichardt, C. L.; Saro, A.; Schrabback, T.; Strazzullo, V.; Stubbs, C. W.; Zenteno, A.

    2016-02-18

    We present a detection of the enhancement in the number densities of background galaxies induced from lensing magnification and use it to test the Sunyaev-Zel'dovich effect (SZE) inferred masses in a sample of 19 galaxy clusters with median redshift z≃0.42 selected from the South Pole Telescope SPT-SZ survey. Two background galaxy populations are selected for this study through their photometric colours; they have median redshifts zmedian≃0.9 (low-z background) and zmedian≃1.8 (high-z background). Stacking these populations, we detect the magnification bias effect at 3.3σ and 1.3σ for the low- and high-z backgrounds, respectively. We fit NFW models simultaneously to all observed magnification bias profiles to estimate the multiplicative factor η that describes the ratio of the weak lensing mass to the mass inferred from the SZE observable-mass relation. We further quantify systematic uncertainties in η resulting from the photometric noise and bias, the cluster galaxy contamination and the estimations of the background properties. The resulting η for the combined background populations with 1σ uncertainties is 0.83 ± 0.24(stat) ± 0.074(sys), indicating good consistency between the lensing and the SZE-inferred masses. We also use our best-fit η to predict the weak lensing shear profiles and compare these predictions with observations, showing agreement between the magnification and shear mass constraints. Our work demonstrates the promise of using the magnification as a complementary method to estimate cluster masses in large surveys.

  20. Detection of enhancement in number densities of background galaxies due to magnification by massive galaxy clusters

    DOE PAGES

    Chiu, I.; Dietrich, J. P.; Mohr, J.; ...

    2016-02-18

    We present a detection of the enhancement in the number densities of background galaxies induced from lensing magnification and use it to test the Sunyaev-Zel'dovich effect (SZE) inferred masses in a sample of 19 galaxy clusters with median redshift z≃0.42 selected from the South Pole Telescope SPT-SZ survey. Two background galaxy populations are selected for this study through their photometric colours; they have median redshifts zmedian≃0.9 (low-z background) and zmedian≃1.8 (high-z background). Stacking these populations, we detect the magnification bias effect at 3.3σ and 1.3σ for the low- and high-z backgrounds, respectively. We fit NFW models simultaneously to all observedmore » magnification bias profiles to estimate the multiplicative factor η that describes the ratio of the weak lensing mass to the mass inferred from the SZE observable-mass relation. We further quantify systematic uncertainties in η resulting from the photometric noise and bias, the cluster galaxy contamination and the estimations of the background properties. The resulting η for the combined background populations with 1σ uncertainties is 0.83 ± 0.24(stat) ± 0.074(sys), indicating good consistency between the lensing and the SZE-inferred masses. We also use our best-fit η to predict the weak lensing shear profiles and compare these predictions with observations, showing agreement between the magnification and shear mass constraints. Our work demonstrates the promise of using the magnification as a complementary method to estimate cluster masses in large surveys.« less

  1. Fluctuations in microwave background radiation due to secondary ionization of the intergalactic gas in the universe

    NASA Technical Reports Server (NTRS)

    Sunyayev, R. A.

    1979-01-01

    Secondary heating and ionization of the intergalactic gas at redshifts z approximately 10-30 could lead to the large optical depth of the Universe for Thomson scattering and could smooth the primordial fluctuations formed at z approximately 1500. It is shown that the gas motions connected with the large scale density perturbations at z approximately 10-15 must lead to the generation of secondary fluctuations of microwave background. The contribution of the rich clusters of galaxies and young galaxies to the fluctuations of microwave background is also estimated.

  2. Changes in US background ozone due to global anthropogenic emissions from 1970 to 2020

    NASA Astrophysics Data System (ADS)

    Nopmongcol, Uarporn; Jung, Jaegun; Kumar, Naresh; Yarwood, Greg

    2016-09-01

    Estimates of North American and US Background (NAB and USB) ozone (O3) are critical in setting and implementing the US National Ambient Air Quality Standards (NAAQS) and therefore influence population exposure to O3 across the US. NAB is defined as the O3 concentration in the absence of anthropogenic O3 precursor emissions from North America whereas USB excludes anthropogenic emissions inside the US alone. NAB and USB vary geographically and with time of year. Analyses of O3 trends at rural locations near the west coast suggest that background O3 is rising in response to increasing non-US emissions. As the O3 NAAQS is lowered, rising background O3 would make attaining the NAAQS more difficult. Most studies of changing US background O3 have inferred trends from observations whereas air quality management decisions tend to rely on models. Thus, it is important that the models used to develop O3 management strategies are able to represent the changes in background O3 in order to increase confidence that air quality management strategies will succeed. We focus on how changing global emissions influence USB rather than the effects of inter-annual meteorological variation or long-term climate change. We use a regional model (CAMx) nested within a global model (GEOS-Chem) to refine our grid resolution over high terrain in the western US and near US borders where USB tends to be higher. We determine USB from CAMx simulations that exclude US anthropogenic emissions. Over five decades, from 1970 to 2020, estimated USB for the annual fourth highest maximum daily 8-h average O3 (H4MDA8) in the western US increased from mostly in the range of 40-55 ppb to 45-60 ppb, but remained below 45 ppb in the eastern US. USB increases in the southwestern US are consistent with rising emissions in Asia and Mexico. USB decreases in the northeast US after 1990 follow declining Canadian emissions. Our results show that the USB increases both for the top 30 MDA8 days and the H4MDA8 (the former

  3. Finding False Positives Planet Candidates Due To Background Eclipsing Binaries in K2

    NASA Astrophysics Data System (ADS)

    Mullally, Fergal; Thompson, Susan E.; Coughlin, Jeffrey; DAVE Team

    2016-06-01

    We adapt the difference image centroid approach, used for finding background eclipsing binaries, to vet K2 planet candidates. Difference image centroids were used with great success to vet planet candidates in the original Kepler mission, where the source of a transit could be identified by subtracting images of out-of-transit cadences from in-transit cadences. To account for K2's roll pattern, we reconstruct out-of-transit images from cadences that are nearby in both time and spacecraft roll angle. We describe the method and discuss some K2 planet candidates which this method suggests are false positives.

  4. Global Health Benefits from Reductions in Background Tropospheric Ozone due to Methane Emission Controls

    NASA Astrophysics Data System (ADS)

    West, J. J.; Mauzerall, D. L.; Fiore, A. M.; Horowitz, L. W.

    2005-05-01

    Increases in background ozone throughout the troposphere are partially attributed to rising anthropogenic methane concentrations, which are projected to continue to increase in the future. Because methane is long-lived and affects background ozone, controls on methane emissions would reduce surface ozone concentrations fairly uniformly around the globe. Epidemiological research indicates that exposure to ozone increases incidence of respiratory ailments and premature mortality. In addition, exposure to ozone reduces agricultural yields and damages natural ecosystems. We use the MOZART-2 global atmospheric chemistry and transport model to estimate the effects on global surface ozone of perturbations in methane emissions. We consider a baseline scenario for 2000 and the 2030 A2 scenario (emissions from the IPCC AR-4 2030 atmospheric chemistry experiments), and examine the impact on ozone of decreasing anthropogenic methane emissions relative to this baseline by 20%. Using the simulated spatially-distributed decreases in surface ozone concentrations resulting from these reductions in methane emissions, we estimate the global benefits to human health in the methane emission reduction scenario. We focus on human mortality, and consider the sensitivity of our estimates to different assumptions of health effect thresholds at low ozone concentrations.

  5. Defocusing of an ion beam propagating in background plasma due to two-stream instability

    SciTech Connect

    Tokluoglu, Erinc; Kaganovich, Igor D.

    2015-04-15

    The current and charge neutralization of charged particle beams by background plasma enable ballistic beam propagation and have a wide range of applications in inertial fusion and high energy density physics. However, the beam-plasma interaction can result in the development of collective instabilities that may have deleterious effects on ballistic propagation of an ion beam. In the case of fast, light-ion beams, non-linear fields created by instabilities can lead to significant defocusing of the beam. We study an ion beam pulse propagating in a background plasma, which is subjected to two-stream instability between the beam ions and plasma electrons, using PIC code LSP. The defocusing effects of the instability on the beam can be much more pronounced in small radius beams. We show through simulations that a beamlet produced from an ion beam passed through an aperture can be used as a diagnostic tool to identify the presence of the two-stream instability and quantify its defocusing effects. The effect can be observed on the Neutralized Drift Compression Experiment-II facility by measuring the spot size of the extracted beamlet propagating through several meters of plasma.

  6. Microwave background fluctuations due to the Sunyaev-Zel'dovich effects in pancakes

    NASA Technical Reports Server (NTRS)

    Subbarao, M. U.; Szalay, A. S.; Schaefer, R. K.; Gulkis, S.; Von Gronefeld, P.

    1994-01-01

    We calculate distortions in the microwave background radiation from the Sunyaev-Zel'dovich effect, produced by hot gas in large (approximately 100 Mpc) pancakes. The large-scale distribution of the pancakes is taken to be that of a Voronoi foam. Fluctuations for this scenario are estimated to be on the order of delta T/T is approximately 10(exp -5). Using computer simulations, we produce several 32 deg x 32 deg images with 0.25 deg resolution. These images show characteristic linear features produced when a pancake is viewed nearly edge-on. By calculating the two-point and the degenerate three-point correlation functions, we are able to statistically detect such non-Gaussian features even in the presence of a relatively large amount of Gaussian noise. The degenerate three-point correlation function is found to be particularly useful since it is insensitive to correlated Gaussian noise. We also smooth our data over a 7 deg Full Width at Half Maximum (FWHM) Gaussian window to simulate the Cosmic Background Explorer Satellite (COBE) observations. We find that under such low-resolution conditions, the features are highly suppressed.

  7. Beam loss and backgrounds in the CDF and D0 detectors due to nuclear elastic beam-gas scattering

    SciTech Connect

    Alexandr I. Drozhdin; Valery A. Lebedev; Nikolai V. Mokhov

    2003-05-27

    Detailed simulations were performed on beam loss rates in the vicinity of the Tevatron Collider detectors due to beam-gas nuclear elastic interactions. It turns out that this component can drive the accelerator-related background rates in the CDF and D0 detectors, exceeding those due to outscattering from collimation system, inelastic beam-gas interactions and other processes [1, 2]. Results of realistic simulations with the STRUCT and MARS codes are presented for the interaction region components and the CDF and D0 detectors. It is shown that a steel mask placed upstream of the detectors can reduce the background rates by almost an order of magnitude.

  8. IS THE COSMIC MICROWAVE BACKGROUND ASYMMETRY DUE TO THE KINEMATIC DIPOLE?

    SciTech Connect

    Naselsky, P.; Zhao, W.; Kim, J.; Chen, S.

    2012-04-10

    Parity violation found in the cosmic microwave background (CMB) radiation is a crucial clue for the non-standard cosmological model or the possible contamination of various foreground residuals and/or calibration of the CMB data sets. In this paper, we study the directional properties of the CMB parity asymmetry by excluding the m = 0 modes in the definition of parity parameters. We find that the preferred directions of the parity parameters coincide with the CMB kinematic dipole, which implies that the CMB parity asymmetry may be connected with the possible contamination of the residual dipole component. We also find that such tendency is not only localized at l = 2, 3, but in the extended multipole ranges up to l {approx} 22.

  9. DETECTORS AND EXPERIMENTAL METHODS: Online measurement of the BEPC II background using RadFET dosimeters

    NASA Astrophysics Data System (ADS)

    Gong, Hui; Li, Jin; Gong, Guang-Hua; Li, Yu-Xiong; Hou, Lei; Shao, Bei-Bei

    2009-09-01

    To monitor the integral dose deposited in the BESIII electromagnetic calorimeter whose performance degrades due to exposure to the BEPC II background, a 400 nm IMPL RadFET dosimeter-based integral dose online monitor system is built. After calibration with the 60Co source and verification with TLD in the pulse radiation fields, an experiment was arranged to measure the BEPC II background online. The results are presented.

  10. What will Europa sound like? Modeling seismic background noise due to tidal cracking events

    NASA Astrophysics Data System (ADS)

    Panning, M. P.; Stähler, S. C.; Huang, H. H.; Vance, S.; Kedar, S.; Lorenz, R. D.; Pike, W. T.

    2016-12-01

    Seismology is a powerful tool for illuminating internal structure and dynamics in planetary bodies. With the plan for a Europa lander next decade, we have the opportunity to place a seismometer on the surface and greatly increase our knowledge of internal structure of the ocean world. In order to maximize return from such an instrument, we need to understand both predicted signals and noise. Instrument noise can be quantified well on Earth, but estimating the ambient noise of a planetary body is significantly more challenging. For Europa, we make an initial range of estimates of ambient noise due to ongoing tidally induced events within the ice shell. We estimate a range of cumulative moment releases based on tidal dissipation energy, and then create an assumed Gutenberg-Richter relationship (e.g. Golombek et al., 1992). We then use this relationship to generate random realizations of event catalogs with a length of 1 day, including all events down to a moment magnitude of -1, and generate continuous 3 component seismic records from these catalogs using a spectral element method (Instaseis/AxiSEM, van Driel et al., 2015). The seismic data are calculated using a range of thermodynamically self-consistent layered models of Europa structure, varying ice shell thickness and attenuation (e.g. Cammarano et al., 2006). The noise records are then used to define overall spectral characteristics of the noise and to test methods to take advantage of the ambient noise, such as autocorrelation techniques. Ambient noise characteristics are also compared with candidate instrument noise models which may be included in future Europa missions. F. Cammarano, V. Lekic, M. Manga, M.P. Panning, and B.A. Romanowicz (2006), "Long-period seismology on Europa: 1. Physically consistent interior models," J. Geophys. Res., 111, E12009, doi: 10.1029/2006JE002710. M. van Driel, L. Krischer, S.C. Stähler, K. Hosseini, and T. Nissen-Meyer (2015), "Instaseis: instant global seismograms based on a

  11. Determination of the health hazards due to background radiation sources in the city of Adapazari, Northwestern Turkey.

    PubMed

    Kapdan, Enis; Altinsoy, Nesrin; Karahan, Gursel; Taskin, Halim

    2011-03-01

    Human body is exposed to ionising radiations both internally and externally by mainly high-energy cosmic ray particles incident on the earth's atmosphere and radioactive nuclides that originated in the earth's crust. The main objective of this study is to assess the health hazards due to environmental radiation sources in the city of Adapazari, one of the most important industrial cities of the country, Northwestern Turkey. For this purpose, natural radiation sources, external terrestrial radiations, cosmic radiations, and inhalation exposures have been investigated. The annual average external terrestrial radiation doses were determined as 0.08 and 0.35 mSv at outdoor and indoor atmospheres, respectively. The annual average cosmic radiation doses were found to be 0.08 and 0.05 mSv for directly ionising photon components and neutron components, respectively. The annual average inhalation exposure doses due to radon and thoron were obtained as 1.42 and 0.19 mSv, respectively, in the region. The annual average effective dose due to natural radiation sources was determined as a total of 2.35 mSv with the predetermined ingestion radiation dose. The lifetime cancer risk due to the background ionising radiations has been determined as 0.9×10(-2) for the residents of the Adapazari city, with the average lifespan of 70 years. The results of the effective doses due to background radiation sources in the region and the worldwide averages were discussed.

  12. Experimental and theoretical studies of particle generation afterlaser ablation of copper with background gas at atmosphericpressure

    SciTech Connect

    Wen, Sy-Bor; Mao, Xianglei; Greif, Ralph; Russo, Richard E.

    2007-05-31

    Laser ablation has proven to be an effective method for generating nanoparticles; particles are produced in the laser induced vapor plume during the cooling stage. To understand the in-situ condensation process, a series of time resolved light scattering images were recorded and analyzed. Significant changes in the condensation rate and the shape of the condensed aerosol plume were observed in two background gases, helium and argon. The primary particle shape and size distribution were measured using a transmission electron microscope (TEM), a scanning electron microscope (SEM) and a differential mobility analyzer (DMA). The gas dynamics simulation included nucleation and coagulation within the vapor plume, heat and mass transfer from the vapor plume to the background gas, and heat transfer to the sample. The experimental data and the calculated evolution of the shape of the vapor plume showed the same trend for the spatial distribution of the condensed particles in both background gases. The simulated particle size distribution also qualitatively agreed with the experimental data. It was determined that the laser energy, the physical properties of the background gas (conductivity, diffusivity and viscosity), and the shape of the ablation system (ablation chamber and the layout of the sample) have strong effects on the condensation process and the subsequent sizes, shapes and degree of aggregation of the particles.

  13. Experimental observation of self excited co-rotating multiple vortices in a dusty plasma with inhomogeneous plasma background

    NASA Astrophysics Data System (ADS)

    Choudhary, Mangilal; Mukherjee, S.; Bandyopadhyay, P.

    2017-03-01

    We report an experimental observation of multiple co-rotating vortices in an extended dust column in the background of an inhomogeneous diffused plasma. An inductively coupled rf discharge is initiated in the background of argon gas in the source region. This plasma was later found to diffuse into the main experimental chamber. A secondary DC glow discharge plasma is produced to introduce dust particles into the plasma volume. These micron-sized poly-disperse dust particles get charged in the background of the DC plasma and are transported by the ambipolar electric field of the diffused plasma. These transported particles are found to be confined in an electrostatic potential well, where the resultant electric field due to the diffused plasma (ambipolar E-field) and glass wall charging (sheath E-field) holds the micron-sized particles against the gravity. Multiple co-rotating (anti-clockwise) dust vortices are observed in the dust cloud for a particular discharge condition. The transition from multiple vortices to a single dust vortex is observed when input rf power is lowered. The occurrence of these vortices is explained on the basis of the charge gradient of dust particles, which is orthogonal to the ion drag force. The charge gradient is a consequence of the plasma inhomogeneity along the dust cloud length. The detailed nature and the reason for multiple vortices are still under investigation through further experiments; however, preliminary qualitative understanding is discussed based on the characteristic scale length of the dust vortex. There is a characteristic size of the vortex in the dusty plasma; therefore, multiple vortices could possibly be formed in an extended dusty plasma with inhomogeneous plasma background. The experimental results on the vortex motion of particles are compared with a theoretical model and are found to be in close agreement.

  14. Promoting menstrual health among persian adolescent girls from low socioeconomic backgrounds: a quasi-experimental study

    PubMed Central

    2012-01-01

    Background Research in the past decade has revealed average to poor menstrual health among many Iranian girls. The present study investigated the effectiveness of a health promotion project on improving menstrual health in adolescent girls in Iran. Methods A quasi-experimental study was conducted to evaluate the effectiveness of the health intervention program. A total of 698 students (study participants and controls) in several schools in Mazandaran province, Iran were included. The project comprised 10 two-hour educational sessions. Educational topics included the significance of adolescence, physical and emotional changes during adolescence, pubertal and menstruation health and premenstrual syndrome. A self-administered questionnaire measuring demographic characteristics, behaviors during menstruation, menstrual patterns, sources of information about menstruation and personal health data was administered. The questionnaire was administered to all participating students after the experimental group received the training. Results Among the most significant results was the impact of educational sessions on bathing and genital hygiene. A total of 61.6% in the experimental group compared with 49.3% in the control group engaged in usual bathing during menstruation (p = 0.002). Individual health status was significantly statistically correlated with menstrual health. Attitude towards menstruation was also significantly related to menstrual health. Conclusions The present study confirms that educational interventions, such as the health promotion project in this study, can be quite effective in promoting menstrual health. PMID:22420743

  15. Pathobiology of aging mice and GEM: background strains and experimental design.

    PubMed

    Brayton, C F; Treuting, P M; Ward, J M

    2012-01-01

    The use of induced and spontaneous mutant mice and genetically engineered mice (and combinations thereof) to study cancers and other aging phenotypes to advance improved functional human life spans will involve studies of aging mice. Genetic background contributes to pathology phenotypes and to causes of death as well as to longevity. Increased recognition of expected phenotypes, experimental variables that influence phenotypes and research outcomes, and experimental design options and rationales can maximize the utility of genetically engineered mice (GEM) models to translational research on aging. This review aims to provide resources to enhance the design and practice of chronic and longevity studies involving GEM. C57BL6, 129, and FVB/N strains are emphasized because of their widespread use in the generation of knockout, transgenic, and conditional mutant GEM. Resources are included also for pathology of other inbred strain families, including A, AKR, BALB/c, C3H, C57L, C58, CBA, DBA, GR, NOD.scid, SAMP, and SJL/J, and non-inbred mice, including 4WC, AB6F1, Ames dwarf, B6, 129, B6C3F1, BALB/c,129, Het3, nude, SENCAR, and several Swiss stocks. Experimental strategies for long-term cross-sectional and longitudinal studies to assess causes of or contributors to death, disease burden, spectrum of pathology phenotypes, longevity, and functional healthy life spans (health spans) are compared and discussed.

  16. Experimental methods in aquatic respirometry: the importance of mixing devices and accounting for background respiration.

    PubMed

    Rodgers, G G; Tenzing, P; Clark, T D

    2016-01-01

    In light of an increasing trend in fish biology towards using static respirometry techniques without the inclusion of a mixing mechanism and without accurately accounting for the influence of microbial (background) respiration, this paper quantifies the effect of these approaches on the oxygen consumption rates (ṀO2 ) measured from juvenile barramundi Lates calcarifer (mean ± s.e. mass = 20·31 ± 0·81 g) and adult spiny chromis damselfish Acanthochromis polyacanthus (22·03 ± 2·53 g). Background respiration changed consistently and in a sigmoidal manner over time in the treatment with a mixing device (inline recirculation pump), whereas attempts to measure background respiration in the non-mixed treatment yielded highly variable estimates of ṀO2 that were probably artefacts due to the lack of water movement over the oxygen sensor during measurement periods. This had clear consequences when accounting for background respiration in the calculations of fish ṀO2 . Exclusion of a mixing device caused a significantly lower estimate of ṀO2 in both species and reduced the capacity to detect differences between individuals as well as differences within an individual over time. There was evidence to suggest that the magnitude of these effects was dependent on the spontaneous activity levels of the fish, as the difference between mixed and non-mixed treatments was more pronounced for L. calcarifer (sedentary) than for A. polyacanthus (more spontaneously active). It is clear that respirometry set-ups for sedentary species must contain a mixing device to prevent oxygen stratification inside the respirometer. While more active species may provide a higher level of water mixing during respirometry measurements and theoretically reduce the need for a mixing device, the level of mixing cannot be quantified and may change with diurnal cycles in activity. To ensure consistency across studies without relying on fish activity levels, and to enable accurate assessments of

  17. Experimental demonstration of linear precompensation of a nonlinear transfer function due to second-harmonic generation.

    PubMed

    Vidal, Sébastien; Luce, Jacques; Penninckx, Denis

    2011-01-01

    We report on what we believe is the first experimental demonstration of the linear precompensation of a nonlinear transfer function due to frequency conversion. As a proof of principle, we show the effective precompensation with an interferometric filter of FM-to-AM conversion due to second-harmonic generation in a potassium titanyl phosphate crystal.

  18. Experimental Investigation of the Interaction of Blast Waves Generated by Exploding Wires using Background Oriented Schlieren

    NASA Astrophysics Data System (ADS)

    Gross, Jonathan; Eliasson, Veronica

    2015-11-01

    Work has been performed to experimentally characterize the interaction of a multiple blast waves. The blast waves were generated using an exploding wire system. This system can store up to 400 J of energy in a high voltage capacitor bank. By discharging the capacitors through wires of a diameter of 150 μm it was possible to produce blast waves with Mach numbers as high as 2.3 at a distance of 40 mm from the center of the blast. A parametric study was performed to measure the behavior of the shocks for a variety of wire thicknesses, voltages, and separation distances. Additionally a background oriented schlieren system was used to quantify the flowfield behind the shocks. The interaction of the shocks featured expected nonlinear phenomena such as the presence of Mach stems, and showed good agreement with results in the shock wave literature. This investigation lays the groundwork for subsequent research that will use exploding wires to experimentally reproduce conditions investigated numerically, in which the effects of multiple converging blast waves on a central target were investigated.

  19. Experimental investigation of plasma relaxation using a compact coaxial magnetized plasma gun in a background plasma

    NASA Astrophysics Data System (ADS)

    Zhang, Yue; Lynn, Alan; Gilmore, Mark; Hsu, Scott; University of New Mexico Collaboration; Los Alamos National Laboratory Collaboration

    2013-10-01

    A compact coaxial plasma gun is employed for experimental studies of plasma relaxation in a low density background plasma. Experiments are being conducted in the linear HelCat device at UNM. These studies will advance the knowledge of basic plasma physics in the areas of magnetic relaxation and space and astrophysical plasmas, including the evolution of active galactic jets/radio lobes within the intergalactic medium. The gun is powered by a 120pF ignitron-switched capacitor bank which is operated in a range of 5-10 kV and ~100 kA. Multiple diagnostics are employed to investigate plasma relaxation process. Magnetized Argon plasma bubbles with velocities ~1.2Cs and densities ~1020 m-3 have been achieved. Different distinct regimes of operation with qualitatively different dynamics are identified by fast CCD camera images, with the parameter determining the operation regime. Additionally, a B-dot probe array is employed to measure the spatial toroidal and poloidal magnetic flux evolution to identify detached plasma bubble configurations. Experimental data and analysis will be presented.

  20. Nonlinear expansion and heating of a nonneutral electron plasma due to elastic collisions with background neutral gas

    SciTech Connect

    Davidson, R.C.; Chao, E.H.

    1996-07-01

    This paper investigates theoretically the heating and nonlinear expansion of a nonneutral electron plasma due to elastic collisions with constant collision frequency {nu}{sub {ital en}} between the plasma electrons and a background neutral gas. The model treats the electrons as a strongly magnetized fluid ({omega}{sub {ital pe}}{sup 2}/{omega}{sub {ital ce}}{sup 2}{lt}1) immersed in a uniform magnetic field {ital B}{sub 0}{ital {bold {cflx e}}}{sub {ital z}}. The model also assumes an axisymmetric plasma column ({partial_derivative}/{partial_derivative}{theta}=0) with negligible axial variation ({partial_derivative}/{partial_derivative}{ital z}=0), and that the process of heat conduction is sufficiently fast that the electrons have relaxed through electron-electron collisions to a quasi-equilibrium state with scalar pressure {ital P}({ital r},{ital t})={ital n}({ital r},{ital t}){ital T}, and isothermal temperature {ital T}. Assuming that the electrons undergo elastic collisions with infinitely massive background gas atoms, global energy conservation is used to calculate the electron heating rate, {ital dT}({ital t})/{ital dt}, as the plasma column expands on a time scale {tau}{sub {ital diff}}{approximately}({omega}{sub {ital pe}}{sup 2}{nu}{sub {ital en}}/{omega}{sub {ital ce}}{sup 2} ){sup {minus}1}, and the electrostatic potential energy decreases. Coupled dynamical equations that describe the nonlinear evolution of the mean-square column radius {ital r}{sup 2}{sub 0}({ital t}) and electron temperature {ital T}({ital t}) are derived and solved numerically. {copyright} {ital 1996 American Institute of Physics.}

  1. Uncertainty in techno-economic estimates of cellulosic ethanol production due to experimental measurement uncertainty

    PubMed Central

    2012-01-01

    Background Cost-effective production of lignocellulosic biofuels remains a major financial and technical challenge at the industrial scale. A critical tool in biofuels process development is the techno-economic (TE) model, which calculates biofuel production costs using a process model and an economic model. The process model solves mass and energy balances for each unit, and the economic model estimates capital and operating costs from the process model based on economic assumptions. The process model inputs include experimental data on the feedstock composition and intermediate product yields for each unit. These experimental yield data are calculated from primary measurements. Uncertainty in these primary measurements is propagated to the calculated yields, to the process model, and ultimately to the economic model. Thus, outputs of the TE model have a minimum uncertainty associated with the uncertainty in the primary measurements. Results We calculate the uncertainty in the Minimum Ethanol Selling Price (MESP) estimate for lignocellulosic ethanol production via a biochemical conversion process: dilute sulfuric acid pretreatment of corn stover followed by enzymatic hydrolysis and co-fermentation of the resulting sugars to ethanol. We perform a sensitivity analysis on the TE model and identify the feedstock composition and conversion yields from three unit operations (xylose from pretreatment, glucose from enzymatic hydrolysis, and ethanol from fermentation) as the most important variables. The uncertainty in the pretreatment xylose yield arises from multiple measurements, whereas the glucose and ethanol yields from enzymatic hydrolysis and fermentation, respectively, are dominated by a single measurement: the fraction of insoluble solids (fIS) in the biomass slurries. Conclusions We calculate a $0.15/gal uncertainty in MESP from the TE model due to uncertainties in primary measurements. This result sets a lower bound on the error bars of the TE model predictions

  2. Advanced system experimental facility: solid waste to methane gas. Background and process description

    SciTech Connect

    Isaacson, R.; Pfeffer, J.

    1981-03-01

    The Refuse Conversion to Methane Facility in Pompano Beach, Florida, a 100-ton/day experimental plant to convert municipal solid waste (MSW) to methane for fuel, has been built and is being tested. The facility has been designed to assess the technical merit of anaerobic digestion of the MSW process. Approximately 40 ton/day of volatile solids are fed to the digesters; of this, about 25 ton/day will be converted to gases. For each pound of volatile solids destroyed, 6.6 std. ft/sup 3/ of methane gas and 6.6 std. ft/sup 3/ of CO/sub 2/ will be produced. Thus, the plant will yield approximately 330,000 std. ft/sup 3//day each of methane and CO/sub 2/. This project provides a critical test of the most important process variables, thus allowing judgments to be made on scale-up considerations. The successful operation of this facility will yield information with a significant impact on potential commercial-scale plant developments. The background and theory involved in applying this technology to MSW, as well as details of the specific process line, are presented.

  3. Comparative evaluation of two vaccine candidates against experimental leishmaniasis due to Leishmania major infection in four inbred mouse strains.

    PubMed

    Benhnini, Fouad; Chenik, Mehdi; Laouini, Dhafer; Louzir, Hechmi; Cazenave, Pierre André; Dellagi, Koussay

    2009-11-01

    Experimental leishmaniasis in BALB/c and C57BL/6 mice are the most investigated murine models that were used for the preclinical evaluation of Leishmania vaccine candidates. We have previously described two new inbred mouse strains named PWK and MAI issued from feral founders that also support the development of experimental leishmaniasis due to L. major. In this study, we sought to determine whether different mouse inbred strains generate concordant or discordant results when used to evaluate the potential of Leishmania proteins to protect against experimental leishmaniasis. To this end, two Leishmania proteins, namely, LACK (for Leishmania homolog of receptor for activated C kinase) and LmPDI (for L. major protein disulfide isomerase) were compared for their capacity to protect against experimental leishmaniasis in PWK, MAI, BALB/c, and C57BL/6 inbred mouse strains. Our data show that the capacity of Leishmania proteins to confer protection depends on the mouse strain used, stressing the important role played by the genetic background in shaping the immune response against the pathogen. These results may have important implications for the preclinical evaluation of candidate Leishmania vaccines: rather than using a single mouse strain, a panel of different inbred strains of various genetic backgrounds should be tested in parallel. The antigen that confers protection in the larger range of inbred strains may have better chances to be also protective in outbred human populations and should be selected for clinical trials.

  4. Modeling and experimental results of low-background extrinsic double-injection IR detector response

    NASA Astrophysics Data System (ADS)

    Zaletaev, N. B.; Filachev, A. M.; Ponomarenko, V. P.; Stafeev, V. I.

    2006-05-01

    Bias-dependent response of an extrinsic double-injection IR detector under irradiation from extrinsic and intrinsic responsivity spectral ranges was obtained analytically and through numerical modeling. The model includes the transient response and generation-recombination noise as well. It is shown that a great increase in current responsivity (by orders of magnitude) without essential change in detectivity can take place in the range of extrinsic responsivity for detectors on semiconductor materials with long-lifetime minority charge carriers if double-injection photodiodes are made on them instead photoconductive detectors. Field dependence of the lifetimes and mobilities of charge carriers essentially influences detector characteristics especially in the voltage range where the drift length of majority carriers is greater than the distance between the contacts. The model developed is in good agreement with experimental data obtained for n-Si:Cd, p-Ge:Au, and Ge:Hg diodes, as well as for diamond detectors of radiations. A BLIP-detection responsivity of about 2000 A/W (for a wavelength of 10 micrometers) for Ge:Hg diodes has been reached in a frequency range of 500 Hz under a background of 6 x 10 11 cm -2s -1 at a temperature of 20 K. Possibilities of optimization of detector performance are discussed. Extrinsic double-injection photodiodes and other detectors of radiations with internal gain based on double injection are reasonable to use in the systems liable to strong disturbance action, in particular to vibrations, because high responsivity can ensure higher resistance to interference.

  5. Impairment due to alcohol, tetrahydrocannabinol, and benzodiazepines in impaired drivers compared to experimental studies.

    PubMed

    Høiseth, Gudrun; Berg-Hansen, Grim Otto; Øiestad, Åse Marit L; Bachs, Liliana; Mørland, Jørg

    2017-04-03

    relationship between drug concentration and impairment was seen for both experimental studies and real-life cases. We believe that the present study strengthens the background for using experimental studies to establish fixed concentration limits for drunk and drugged drivers, but experimental studies in an impaired driver population could further expand our knowledge.

  6. Experimental study of neutron induced background noise on gated x-ray framing cameras

    SciTech Connect

    Izumi, N.; Hagmann, C.; Stone, G.; Hey, D.; Glenn, S.; Conder, A.; Teruya, A.; Sorce, C.; Tommasini, R.; Stoeffl, W.; Springer, P.; Landen, O. L.; Eckart, M.; Mackinnon, A. J.; Koch, J. A.; Bradley, D. K.; Bell, P.; Herrmann, H. W.; Kyrala, G. A.; Bahukutumbi, R.; and others

    2010-10-15

    A temporally gated x-ray framing camera based on a proximity focus microchannel plate is one of the most important diagnostic tools of inertial confinement fusion experiments. However, fusion neutrons produced in imploded capsules interact with structures surrounding the camera and produce background to x-ray signals. To understand the mechanisms of this neutron induced background, we tested several gated x-ray cameras in the presence of 14 MeV neutrons produced at the Omega laser facility. Differences between background levels observed with photographic film readout and charge-coupled-device readout have been studied.

  7. Experimental study of variations in background radiation and the effect on Nuclear Car Wash sensitivity

    SciTech Connect

    Church, J; Slaughter, D; Norman, E; Asztalos, S; Biltoft, P

    2007-02-07

    Error rates in a cargo screening system such as the Nuclear Car Wash [1-7] depend on the standard deviation of the background radiation count rate. Because the Nuclear Car Wash is an active interrogation technique, the radiation signal for fissile material must be detected above a background count rate consisting of cosmic, ambient, and neutron-activated radiations. It was suggested previously [1,6] that the Corresponding negative repercussions for the sensitivity of the system were shown. Therefore, to assure the most accurate estimation of the variation, experiments have been performed to quantify components of the actual variance in the background count rate, including variations in generator power, irradiation time, and container contents. The background variance is determined by these experiments to be a factor of 2 smaller than values assumed in previous analyses, resulting in substantially improved projections of system performance for the Nuclear Car Wash.

  8. Experimental Background Studies in the Two Photon Exchange (TPE) Experiment at Jefferson Lab

    SciTech Connect

    Cristian Peña, W. K. Brooks, Hayk Hakobyan

    2010-08-01

    This work is based on the improvement of an existing simulation for the two photon exchange (TPE) experiment at Jefferson Lab developed within the GEANT4 framework. This experiment will determine the ratio of the positron-proton elastic scattering cross section and the electron-proton elastic scattering cross section with high precision. To accomplish this measurement requires the use of a variety of devices and complex arrangements, creating background particles that manage to reach the detector system (CLAS). A number of test runs have identified the sources of background in the detector guided by previous simulations. Even so, the remaining background can be reduced considerably by the microscopic identification and locating of the background sources performed by our new simulation.

  9. Experimental Background Studies in the Two Photon Exchange (TPE) Experiment at Jefferson Lab

    SciTech Connect

    Pena, Cristian; Brooks, W. K.; Hakobyan, Hayk

    2010-08-04

    This work is based on the improvement of an existing simulation for the two photon exchange (TPE) experiment at Jefferson Lab developed within the GEANT4 framework. This experiment will determine the ratio of the positron-proton elastic scattering cross section and the electron-proton elastic scattering cross section with high precision. To accomplish this measurement requires the use of a variety of devices and complex arrangements, creating background particles that manage to reach the detector system (CLAS). A number of test runs have identified the sources of background in the detector guided by previous simulations. Even so, the remaining background can be reduced considerably by the microscopic identification and locating of the background sources performed by our new simulation.

  10. Experimental Study on Impact Load on a Dam Due to Debris Flow

    Treesearch

    lwao Miyoshi

    1991-01-01

    When a dam is struck by mud or debris flow, it is put under a great impact load and sometimes is destroyed. To prevent such destruction, it is important to perform basic research about the impact load on a dam due to debris flow. Thus, we have made an experimental study and tried to establish a method to estimate such a impact load on the dam. The experiment was...

  11. Can the cosmic x ray and gamma ray background be due to reflection of a steep power law spectrum and Compton scattering by relativistic electrons?

    NASA Technical Reports Server (NTRS)

    Zycki, Piotr T.; Zdziarski, Andrzej A.; Svensson, Roland

    1991-01-01

    We reconsider the recent model for the origin in the cosmic X-ray and gamma-ray background by Rogers and Field. The background in the model is due to an unresolved population of AGNs. An individual AGN spectrum contains three components: a power law with the energy index of alpha = 1.1, an enhanced reflection component, and a component from Compton scattering by relativistic electrons with a low energy cutoff at some minimum Lorentz factor, gamma(sub min) much greater than 1. The MeV bump seen in the gamma-ray background is then explained by inverse Compton emission by the electrons. We show that the model does not reproduce the shape of the observed X-ray and gamma-ray background below 10 MeV and that it overproduces the background at larger energies. Furthermore, we find the assumptions made for the Compton component to be physically inconsistent. Relaxing the inconsistent assumptions leads to model spectra even more different from that of the observed cosmic background. Thus, we can reject the hypothesis that the high-energy cosmic background is due to the described model.

  12. Vibrations inside buildings due to subway railway traffic. Experimental validation of a comprehensive prediction model.

    PubMed

    Lopes, Patrícia; Ruiz, Jésus Fernández; Alves Costa, Pedro; Medina Rodríguez, L; Cardoso, António Silva

    2016-10-15

    The present paper focuses on the experimental validation of a numerical approach previously proposed by the authors for the prediction of vibrations inside buildings due to railway traffic in tunnels. The numerical model is based on the concept of dynamic substructuring and is composed by three autonomous models to simulate the following main parts of the problem: i) generation of vibrations (train-track interaction); ii) propagation of vibrations (track-tunnel-ground system); iii) reception of vibrations (building coupled to the ground). The experimental validation consists in the comparison between the results predicted by the proposed numerical model and the measurements performed inside a building due to the railway traffic in a shallow tunnel located in Madrid. Apart from the brief description of the numerical model and of the case study, the main options and simplifications adopted on the numerical modeling strategy are discussed. The balance adopted between accuracy and simplicity of the numerical approach proved to be a path to follow in order to transfer knowledge to engineering practice. Finally, the comparison between numerical and experimental results allowed finding a good agreement between both, fact that ensures the ability of the proposed modeling strategy to deal with real engineering practical problems. Copyright © 2015 Elsevier B.V. All rights reserved.

  13. Beam Losses and Background Loads on Collider Detectors Due to Beam-Gas Interactions in the LHC

    SciTech Connect

    Drozhdin, A.I.; Mokhov, N.V.; Striganov, S.I.; /Fermilab

    2009-04-01

    With a fully-operational high-efficient collimation system in the LHC, nuclear interactions of circulating protons with residual gas in the machine beam pipe can be a major source of beam losses in the vicinity of the collider detectors, responsible for the machine-induced backgrounds. Realistic modeling of Coulomb scattering, elastic and inelastic interactions of 7-TeV protons with nuclei in the vacuum chamber of the cold and warm sections of the LHC ring--with an appropriate pressure profile--is performed with the STRUCT and MARS15 codes. Multi-turn tracking of the primary beams, propagation of secondaries through the lattice, their interception by the tertiary collimators TCT as well as properties of corresponding particle distributions at the CMS and ATLAS detectors are studied in great detail and results presented in this paper.

  14. Detection of micrometastasis by cytokeratin 20 RT-PCR is limited due to stable background transcription in granulocytes

    PubMed Central

    Jung, R; Petersen, K; Krüger, W; Wolf, M; Wagener, C; Zander, A; Neumaier, M

    1999-01-01

    The reverse transcription polymerase chain reaction (RT-PCR) amplification of cytokeratin 20 (CK20) mRNA is considered a promising candidate method for the detection of circulating tumour cells in bone marrow and peripheral blood of cancer patients. In this study we have investigated the diagnostic specificity of the CK20 mRNA detection in samples from healthy donors (HD; n = 33), intensive care units patients (ICU; n = 20) and bone marrow obtained from patients suffering from chronic inflammatory diseases (CID; n = 14). RNAs purified from stabilized lysates showed positive results in 24% of the HD group (8/33), 35% of the ICU group (8/20) and in 40% of the CID group (5/14). The use of Ficoll gradients to separate nucleated cells completely restored the specificity of this CK20 RT-PCR assay. The CK20-expressing cells are positively identified to belong to the granulocyte fraction of leucocytes, which appear to express the gene on a background level. Our results demonstrate for the first time that CK20 mRNA expression is not limited to epithelium. Its occurrence in normal granulocytes has to be considered in tests designed to detect circulating cancer cells or micrometastases. © 1999 Cancer Research Campaign PMID:10555760

  15. Changes in the physico-chemical properties of Amazonian aerosols from background conditions due to urban impacts in Central Amazonia.

    NASA Astrophysics Data System (ADS)

    Artaxo, P.; Barbosa, H. M.; Brito, J.; Carbone, S.; Fiorese, C.; Andre, B.; Rizzo, L. V.; Ditas, F.; Pöhlker, C.; Pöhlker, M. L.; Saturno, J.; Holanda, B. A.; Wang, J.; Souza, R. A. F. D.; Machado, L.; Andreae, M. O.; Martin, S. T.

    2016-12-01

    The GoAmazon 2014/15 experiment (Observations and Modeling of the Green Ocean Amazon) was a great opportunity to study how urbanization can change aerosol properties under pristine conditions in a tropical rain forest. The experiment took place from January 2014 to December 2015 in the vicinity of Manaus, Brazil, where several sampling stations were operated. Natural biogenic aerosol properties were studied in 3 sampling stations upwind of Manaus (ATTO (T0a), ZF2 (T0z) and EMBRAPA (T0e)). Urban impacted aerosols were analysed in two downwind sampling stations at Tiwa (T2) and Manacapuru (T3). Properties analysed were size distribution, scattering and absorption, composition, vertical profiles and others. Remote sensing measurements were done using AERONET and MODIS, while extensive ground based measurements were done in all sampling stations. Remote sensing measurements shows important changes in aerosol optical depth (AOD), especially in the aerosol absorption component. It was also observed a reduction in cloud droplet size downwind of Manaus for liquid phase clouds. Changes in particle number and size were also very significant, that reflected in changes in the aerosol radiative forcing (RF) before and after Manaus plume. In the dry season, an average RF of -24 w/m² was observed upwind, while -17 w/m² was observed downwind, due to large scale biomass burning aerosols. Single scattering albedo (SSA) at 550 nm changed from a high value of 0.96 upwind to 0.84 downwind due to the increase in absorbing aerosols in the wet season. In the dry season, SSA at 550nm changed from 0.95 to 0.87. Aerosol composition showed a large dominance of organic aerosols for all sites, accounting for 65-75% of PM1 non refractory aerosol. Most of these were secondary organic aerosol (SOA), with very low sulfate and nitrate concentrations. The influence of the Manaus plume on aerosol properties was more intense during the wet season, because in the dry season a significant amount of

  16. An Experimental Investigation of the Structural Wave Scattering Due to Impedance Discontinuities on a Cylindrical Structure

    SciTech Connect

    Glotzbecker, Ryan Joseph

    2006-05-01

    Experimental, numerical, and analytical work has shown that the response of a shell to a distributed force wave possesses unique characteristics which are dependent on the nature of structure attached to the shell. Specific characteristics which influence the response are the distribution of the discontinuities around the circumference (periodic/aperiodic), the impedance of the discontinuities relative to that of the shell, and the type of impedance (mass or stiffness). Traditional shell theory predicts low frequency, radial-dominated structural mode shapes of a shell with a sinusoidal distribution of displacement amplitudes. Due to the orthogonal nature of these mode shapes, the response of the structure to a traveling radial force wave with sinusoidal content at a given harmonic is due solely to the response of the mode shape with harmonic content of the same order. Introduction of impedance discontinuities to a shell yield complex mode shapes, which may be characterized by the summation of several harmonic components. These modes are no longer orthogonal in the presence of discontinuities, yielding harmonic content across various modal orders. As a result, a purely sinusoidal forcing function can excite several modes of the structure. Structural scattering as discussed in this paper refers to the phenomena in which a force wave at a given harmonic scatters into the response of modes with different harmonics. An experimental investigation into the harmonic scattering behavior of a shell due to mass discontinuities is presented in this paper. Knowledge of the key structural characteristics which influence scattering and their behavior will allow for a diagnostic tool when assessing the structural response of more complex cylindrical structures. Experimentally obtained data presented in this paper demonstrates some expected scattering characteristics of a cylindrical shell in the presence of periodically and aperiodically distributed masses. Some unique

  17. Achromatic half-wave plate for submillimeter instruments in cosmic microwave background astronomy: experimental characterization.

    PubMed

    Pisano, Giampaolo; Savini, Giorgio; Ade, Peter A R; Haynes, Vic; Gear, Walter K

    2006-09-20

    An achromatic half-wave plate (HWP) to be used in millimeter cosmic microwave background (CMB) polarization experiments has been designed, manufactured, and tested. The design is based on the 5-plates Pancharatnam recipe and it works in the frequency range 85-185 GHz. A model has been used to predict the transmission, reflection, absorption, and phase shift as a function of frequency. The HWP has been tested by using coherent radiation from a back-wave oscillator to investigate its modulation efficiency and with incoherent radiation from a polarizing Fourier transform spectrometer (FTS) to explore its frequency behavior. The FTS measurements have been fitted with an optical performance model which is in excellent agreement with the data. A detailed analysis of the data also allows a precise determination of the HWP fast and slow axes in the frequency band of operation. A list of the HWP performance characteristics is reported including estimates of its cross polarization.

  18. Impact of genetic background and experimental reproducibility on identifying chemical compounds with robust longevity effects

    PubMed Central

    Lucanic, Mark; Plummer, W. Todd; Chen, Esteban; Harke, Jailynn; Foulger, Anna C.; Onken, Brian; Coleman-Hulbert, Anna L.; Dumas, Kathleen J.; Guo, Suzhen; Johnson, Erik; Bhaumik, Dipa; Xue, Jian; Crist, Anna B.; Presley, Michael P.; Harinath, Girish; Sedore, Christine A.; Chamoli, Manish; Kamat, Shaunak; Chen, Michelle K.; Angeli, Suzanne; Chang, Christina; Willis, John H.; Edgar, Daniel; Royal, Mary Anne; Chao, Elizabeth A.; Patel, Shobhna; Garrett, Theo; Ibanez-Ventoso, Carolina; Hope, June; Kish, Jason L; Guo, Max; Lithgow, Gordon J.; Driscoll, Monica; Phillips, Patrick C.

    2017-01-01

    Limiting the debilitating consequences of ageing is a major medical challenge of our time. Robust pharmacological interventions that promote healthy ageing across diverse genetic backgrounds may engage conserved longevity pathways. Here we report results from the Caenorhabditis Intervention Testing Program in assessing longevity variation across 22 Caenorhabditis strains spanning 3 species, using multiple replicates collected across three independent laboratories. Reproducibility between test sites is high, whereas individual trial reproducibility is relatively low. Of ten pro-longevity chemicals tested, six significantly extend lifespan in at least one strain. Three reported dietary restriction mimetics are mainly effective across C. elegans strains, indicating species and strain-specific responses. In contrast, the amyloid dye ThioflavinT is both potent and robust across the strains. Our results highlight promising pharmacological leads and demonstrate the importance of assessing lifespans of discrete cohorts across repeat studies to capture biological variation in the search for reproducible ageing interventions. PMID:28220799

  19. Center of Pressure Displacement of Standing Posture during Rapid Movements Is Reorganised Due to Experimental Lower Extremity Muscle Pain

    PubMed Central

    Shiozawa, Shinichiro; Hirata, Rogerio Pessoto; Graven-Nielsen, Thomas

    2015-01-01

    Background Postural control during rapid movements may be impaired due to musculoskeletal pain. The purpose of this study was to investigate the effect of experimental knee-related muscle pain on the center of pressure (CoP) displacement in a reaction time task condition. Methods Nine healthy males performed two reaction time tasks (dominant side shoulder flexion and bilateral heel lift) before, during, and after experimental pain induced in the dominant side vastus medialis or the tibialis anterior muscles by hypertonic saline injections. The CoP displacement was extracted from the ipsilateral and contralateral side by two force plates and the net CoP displacement was calculated. Results Compared with non-painful sessions, tibialis anterior muscle pain during the peak and peak-to-peak displacement for the CoP during anticipatory postural adjustments (APAs) of the shoulder task reduced the peak-to-peak displacement of the net CoP in the medial-lateral direction (P<0.05). Tibialis anterior and vastus medialis muscle pain during shoulder flexion task reduced the anterior-posterior peak-to-peak displacement in the ipsilateral side (P<0.05). Conclusions The central nervous system in healthy individuals was sufficiently robust in maintaining the APA characteristics during pain, although the displacement of net and ipsilateral CoP in the medial-lateral and anterior-posterior directions during unilateral fast shoulder movement was altered. PMID:26680777

  20. Photoacoustic Experimental System To Confirm Infrared Absorption Due to Greenhouse Gases

    PubMed Central

    2010-01-01

    An experimental system for detecting infrared absorption using the photoacoustic (PA) effect is described. It is aimed for use at high-school level to illustrate the difference in infrared (IR) absorption among the gases contained in the atmosphere in connection with the greenhouse effect. The experimental system can be built with readily available components and is suitable for small-group experiments. The PA signal from a greenhouse gas (GHG), such as CO2, H2O, and CH4, can be detected down to a concentration of 0.1%. Since the basic theory of the PA effect in gases due to IR absorption is straightforward, the experiments with this PA system are accessible to students. It can be shown that there is a significant difference in IR absorption between GHGs and the major components of the atmosphere, N2, O2, and Ar, which helps students understand that the minor components, that is, the GHGs, determine the IR absorptivity of the atmosphere. PMID:20084177

  1. Photoacoustic Experimental System To Confirm Infrared Absorption Due to Greenhouse Gases.

    PubMed

    Kaneko, Fumitoshi; Monjushiro, Hideaki; Nishiyama, Masaaki; Kasai, Toshio

    2010-01-12

    An experimental system for detecting infrared absorption using the photoacoustic (PA) effect is described. It is aimed for use at high-school level to illustrate the difference in infrared (IR) absorption among the gases contained in the atmosphere in connection with the greenhouse effect. The experimental system can be built with readily available components and is suitable for small-group experiments. The PA signal from a greenhouse gas (GHG), such as CO(2), H(2)O, and CH(4), can be detected down to a concentration of 0.1%. Since the basic theory of the PA effect in gases due to IR absorption is straightforward, the experiments with this PA system are accessible to students. It can be shown that there is a significant difference in IR absorption between GHGs and the major components of the atmosphere, N(2), O(2), and Ar, which helps students understand that the minor components, that is, the GHGs, determine the IR absorptivity of the atmosphere.

  2. Experimental analysis of thread movement in bolted connections due to vibrations

    NASA Technical Reports Server (NTRS)

    Ramey, G. ED; Jenkins, Robert C.

    1994-01-01

    The objective of this study was to identify the main design parameters contributing to loosening of bolts due to vibration and to identify their relative importance and degree of contribution to bolt loosening. Vibration testing was conducted on a shaketable with a controlled-random input in the dynamic testing laboratory of the Structural Test Division of MSFC. Test specimens which contained one test bolt were vibrated for a fixed amount of time and percentage of pre-load loss was measured. Each specimen tested implemented some combination of eleven design parameters as dictated by the design of experiment methodology employed. The eleven design parameters were: bolt size (diameter), lubrication on bolt, hole tolerance, initial pre-load, nut locking device, grip length, thread pitch, lubrication between mating materials, class of fit, joint configuration and mass of configuration. These parameters were chosen for this experiment because they are believed to be the design parameters having the greatest impact on bolt loosening. Two values of each design parameter were used and each combination of parameters tested was subjected to two different directions of vibration and two different g-levels of vibration. One replication was made for each test to gain some indication of experimental error and repeatability and to give some degree of statistical credibility to the data, resulting in a total of 96 tests being performed. The results of the investigation indicated that nut locking devices, joint configuration, fastener size, and mass of configuration were significant in bolt loosening due to vibration. The results of this test can be utilized to further research the complex problem of bolt loosening due to vibration.

  3. Experimental analysis of thread movement in bolted connections due to vibrations

    NASA Technical Reports Server (NTRS)

    Ramsey, G. ED; Jenkins, Robert C.

    1995-01-01

    This is the final report of research project NAS8-39131 #33 sponsored by NASA's George C. Marshall Space Flight Center (MSFC) and carried out by the Civil Engineering Department of Auburn University (Auburn, Alabama) and personnel of MSFC. The objective of this study was to identify the main design parameters contributing to the loosening of bolts due to vibration and to identify their relative importance and degree of contribution to bolt loosening. Vibration testing was conducted on a shaketable with a controlled-random input in the dynamic testing laboratory of the Structural Test Division of MSFC. Test specimens which contained one test bolt were vibrated for a fixed amount of time and a percentage of pre-load loss was measured. Each specimen tested implemented some combination of eleven design parameters as dictated by the design of experiment methodology employed. The eleven design parameters were: bolt size (diameter), lubrication on bolt, hole tolerance, initial pre-load, nut locking device, grip length, thread pitch, lubrication between mating materials, class of fit, joint configuration, and mass of configuration. These parameters were chosen for this experiment because they are believed to be the design parameters having the greatest impact on bolt loosening. Two values of each design parameter were used and each combination of parameters tested was subjected to two different directions of vibration and two different g-levels of vibration. One replication was made for each test to gain some indication of experimental error and repeatability and to give some degree of statistical credibility to the data, resulting in a total of 96 tests being performed. The results of the investigation indicated that nut locking devices, joint configuration, fastener size, and mass of configuration were significant in bolt loosening due to vibration. The results of this test can be utilized to further research the complex problem of bolt loosening due to vibration.

  4. Background considerations for the 2H(7Be,3H)6Be experimental data II: Three-body continuum

    NASA Astrophysics Data System (ADS)

    Chae, K. Y.; Guimarães, V.

    2015-11-01

    The present article reports second background considerations for the experimentally obtained 2H(7Be,3H)6Be differential cross sections. The one-neutron transfer reaction was measured in inverse kinematics by using radioactive 7Be ( t 1/2 = 53.2 days) beams at the Holifield Radioactive Ion Beam Facility of the Oak Ridge National Laboratory in 2004 in order to search for the resonances in the unbound 6Be nucleus. Resonances in this nucleus would affect the 3He(3He,2 p)4He reaction rate of the proton-proton chain occurring in stars such as our sun. The result shows, however, that the direct transfer to 6Be resonances is not particularly strong compared to other reaction channels that can produce tritons in the exit channels. The goals of the present work is to better understand the cross section data from transfer reaction measurements by adopting background considerations using the three-body continuum.

  5. Uncertainty in techno-economic estimates of cellulosic ethanol production due to experimental measurement uncertainty.

    PubMed

    Vicari, Kristin J; Tallam, Sai Sandeep; Shatova, Tatyana; Joo, Koh Kang; Scarlata, Christopher J; Humbird, David; Wolfrum, Edward J; Beckham, Gregg T

    2012-04-17

    Cost-effective production of lignocellulosic biofuels remains a major financial and technical challenge at the industrial scale. A critical tool in biofuels process development is the techno-economic (TE) model, which calculates biofuel production costs using a process model and an economic model. The process model solves mass and energy balances for each unit, and the economic model estimates capital and operating costs from the process model based on economic assumptions. The process model inputs include experimental data on the feedstock composition and intermediate product yields for each unit. These experimental yield data are calculated from primary measurements. Uncertainty in these primary measurements is propagated to the calculated yields, to the process model, and ultimately to the economic model. Thus, outputs of the TE model have a minimum uncertainty associated with the uncertainty in the primary measurements. We calculate the uncertainty in the Minimum Ethanol Selling Price (MESP) estimate for lignocellulosic ethanol production via a biochemical conversion process: dilute sulfuric acid pretreatment of corn stover followed by enzymatic hydrolysis and co-fermentation of the resulting sugars to ethanol. We perform a sensitivity analysis on the TE model and identify the feedstock composition and conversion yields from three unit operations (xylose from pretreatment, glucose from enzymatic hydrolysis, and ethanol from fermentation) as the most important variables. The uncertainty in the pretreatment xylose yield arises from multiple measurements, whereas the glucose and ethanol yields from enzymatic hydrolysis and fermentation, respectively, are dominated by a single measurement: the fraction of insoluble solids (fIS) in the biomass slurries. We calculate a $0.15/gal uncertainty in MESP from the TE model due to uncertainties in primary measurements. This result sets a lower bound on the error bars of the TE model predictions. This analysis highlights the

  6. Experimental analysis of the structure-borne tyre/road noise due to road discontinuities

    NASA Astrophysics Data System (ADS)

    Kindt, P.; Berckmans, D.; De Coninck, F.; Sas, P.; Desmet, W.

    2009-11-01

    Tyre/road noise has become the major source of traffic noise in urban regions. Although tyre/road noise has been studied for decades, little can be found in the literature about the noise resulting from crossing road discontinuities such as expansion joints, railway crossings, and potholes. Both vehicle interior and exterior noise can reach significant peak levels as a result of crossing such a pavement discontinuity. This paper presents an experimental analysis of the generating phenomena of structure borne tyre/road noise due to a road discontinuity. Both exterior and interior tyre/road noise are considered. The influence of driving speed, cleat dimension, inflation pressure, tyre temperature and preload onto the noise generating phenomena is investigated. A novel test setup was designed and built at the K.U. Leuven Noise and Vibration Engineering Laboratory in order to measure the structural and acoustic response of a tyre rolling over a cleat. The vehicle interior noise is analysed by means of a test circuit cleat test.

  7. Inhalation exposures due to radon and thoron ((222)Rn and (220)Rn): Do they differ in high and normal background radiation areas in India?

    PubMed

    Mishra, Rosaline; Sapra, B K; Prajith, R; Rout, R P; Jalaluddin, S; Mayya, Y S

    2015-09-01

    In India, High Background Radiation Areas (HBRAs) due to enhanced levels of naturally occurring radionuclides in soil (thorium and, to a lesser extent, uranium), are located along some parts of the coastal tracts viz. the coastal belt of Kerala, Tamilnadu and Odisha. It is conjectured that these deposits will result in higher emissions of radon isotopes ((222)Rn and (220)Rn) and their daughter products as compared to Normal Background Radiation Areas (NBRAs). While the annual external dose rates contributed by gamma radiations in these areas are about 5-10 times higher, the extent of increase in the inhalation dose rates attributable to (222)Rn and (220)Rn and their decay products is not well quantified. Towards this, systematic indoor surveys were conducted wherein simultaneous measurements of time integrated (222)Rn and (220)Rn gas and their decay product concentrations was carried out in around 800 houses in the HBRAs of Kerala and Odisha to estimate the inhalation doses. All gas measurements were carried out using pin-hole cup dosimeters while the progeny measurements were with samplers and systems based on the Direct radon/thoron Progeny sensors (DRPS/DTPS). To corroborate these passive measurements of decay products concentrations, active sampling was also carried out in a few houses. The results of the surveys provide a strong evidence to conclude that the inhalation doses due to (222)Rn and (220)Rn gas and their decay products in these HBRAs are in the same range as observed in the NBRAs in India.

  8. Autogenic-Feedback Training (AFT) as a preventive method for space motion sickness: Background and experimental design

    NASA Technical Reports Server (NTRS)

    Cowings, Patricia S.; Toscano, William B.

    1993-01-01

    Finding an effective treatment for the motion sickness-like symptoms that occur in space has become a high priority for NASA. The background research is reviewed and the experimental design of a formal life sciences shuttle flight experiment designed to prevent space motion sickness in shuttle crew members is presented. This experiment utilizes a behavioral medicine approach to solving this problem. This method, Autogenic-Feedback Training (AFT), involves training subjects to voluntarily control several of their own physiological responses to environmental stressors. AFT has been used reliably to increase tolerance to motion sickness during ground-based tests in over 200 men and women under a variety of conditions that induce motion sickness, and preliminary evidence from space suggests that AFT may be an effective treatment for space motion sickness as well. Proposed changes to this experiment for future manifests are included.

  9. Photoacoustic Experimental System to Confirm Infrared Absorption Due to Greenhouse Gases

    ERIC Educational Resources Information Center

    Kaneko, Fumitoshi; Monjushiro, Hideaki; Nishiyama, Masayoshi; Kasai, Toshio; Harris, Harold H.

    2010-01-01

    An experimental system for detecting infrared absorption using the photoacoustic (PA) effect is described. It is aimed for use at high-school level to illustrate the difference in infrared (IR) absorption among the gases contained in the atmosphere in connection with the greenhouse effect. The experimental system can be built with readily…

  10. Photoacoustic Experimental System to Confirm Infrared Absorption Due to Greenhouse Gases

    ERIC Educational Resources Information Center

    Kaneko, Fumitoshi; Monjushiro, Hideaki; Nishiyama, Masayoshi; Kasai, Toshio; Harris, Harold H.

    2010-01-01

    An experimental system for detecting infrared absorption using the photoacoustic (PA) effect is described. It is aimed for use at high-school level to illustrate the difference in infrared (IR) absorption among the gases contained in the atmosphere in connection with the greenhouse effect. The experimental system can be built with readily…

  11. Treatment of experimental pneumonia due to penicillin-resistant Streptococcus pneumoniae in immunocompetent rats.

    PubMed Central

    Gavaldà, J; Capdevila, J A; Almirante, B; Otero, J; Ruiz, I; Laguarda, M; Allende, H; Crespo, E; Pigrau, C; Pahissa, A

    1997-01-01

    A model of pneumonia due to Streptococcus pneumoniae resistant to penicillin was developed in immunocompetent Wistar rats and was used to evaluate the efficacies of different doses of penicillin, cefotaxime, cefpirome, and vancomycin. Adult Wistar rats were challenged by intratracheal inoculation with 3 x 10(9) CFU of one strain of S. pneumoniae resistant to penicillin (MICs of penicillin, cefotaxime, cefpirome, and vancomycin, 2, 1, 0.5, and 0.5 microg/ml, respectively) suspended in brain heart broth supplemented with 0.7% agar. The rats experienced a fatal pneumonia, dying within 5 days and with peak mortality (70 to 80%) occurring 48 to 72 h after infection, and the bacterial counts in the lungs persisted from 8.87 +/- 0.3 log10 CFU/g of lung at 24 h of the infection to 9.1 +/- 0.3 log10 CFU/g at 72 h. Four hours after infection the animals were randomized into the following treatment groups: (i) control without treatment, (ii) penicillin G at 100,000 IU/kg of body weight every 2 h, (iii) penicillin G at 250,000 IU/kg every 2 h, (iv) cefotaxime at 100 mg/kg every 2 h, (v) cefpirome at 200 mg/kg every 2 h, and (vi) vancomycin at 50 mg/kg every 8 h. Two different protocols were used for the therapeutic efficacy studies: four doses of beta-lactams and one dose of vancomycin or eight doses of beta-lactams and two doses of vancomycin. Results of the therapy for experimental pneumonia caused by penicillin-resistant S. pneumoniae showed that initially, all the antimicrobial agents tested had similar efficacies, but when we prolonged the treatment, higher doses of penicillin, cefotaxime, and cefpirome were more effective than penicillin at lower doses in decreasing the residual bacterial titers in the lungs. Also, when we extended the treatment, vancomycin was more efficacious than penicillin at lower doses but was less efficacious than higher doses of penicillin or cefpirome. The model that we have developed is simple and amenable for inducing pneumonia in

  12. Virulence Differences among Melissococcus plutonius Strains with Different Genetic Backgrounds in Apis mellifera Larvae under an Improved Experimental Condition

    PubMed Central

    Nakamura, Keiko; Yamazaki, Yuko; Shiraishi, Akiyo; Kobayashi, Sota; Harada, Mariko; Yoshiyama, Mikio; Osaki, Makoto; Okura, Masatoshi; Takamatsu, Daisuke

    2016-01-01

    European foulbrood (EFB) caused by Melissococcus plutonius is an important bacterial disease of honeybee larvae. M. plutonius strains can be grouped into three genetically distinct groups (CC3, CC12 and CC13). Because EFB could not be reproduced in artificially reared honeybee larvae by fastidious strains of CC3 and CC13 previously, we investigated a method to improve experimental conditions using a CC3 strain and found that infection with a potassium-rich diet enhanced proliferation of the fastidious strain in larvae at the early stage of infection, leading to the appearance of clear clinical symptoms. Further comparison of M. plutonius virulence under the conditions revealed that the representative strain of CC12 was extremely virulent and killed all tested bees before pupation, whereas the CC3 strain was less virulent than the CC12 strain, and a part of the infected larvae pupated. In contrast, the tested CC13 strain was avirulent, and as with the non-infected control group, most of the infected brood became adult bees, suggesting differences in the insect-level virulence among M. plutonius strains with different genetic backgrounds. These strains and the improved experimental infection method to evaluate their virulence will be useful tools for further elucidation of the pathogenic mechanisms of EFB. PMID:27625313

  13. Experimental measurements in a large separation bubble due to a simulated glaze ice shape

    NASA Technical Reports Server (NTRS)

    Bragg, M. B.; Khodadoust, A.

    1988-01-01

    The effect of a simulated glaze ice accretion on the aerodynamic performance of a NACA 0012 airfoil was studied experimentally. Two ice shapes were tested, one from an experimentally measured accretion and one from an accretion predicted using a computer model given the same icing conditions. Lift, drag and moment coefficients were measured for the airfoil with both ice shapes, smooth and rough. The aerodynamic performance of the two shapes compared well at positive, but not negative, angles of attack. Split hot-film probe velocity data were presented in the upper surface boundary layer and in the wake. Boundary layer parameters were presented for the separation bubble and in the reattached turbulent boundary layer.

  14. Live Fast, Die Young: Experimental Evidence of Population Extinction Risk due to Climate Change

    PubMed Central

    Bestion, Elvire; Teyssier, Aimeric; Richard, Murielle; Clobert, Jean; Cote, Julien

    2015-01-01

    Evidence has accumulated in recent decades on the drastic impact of climate change on biodiversity. Warming temperatures have induced changes in species physiology, phenology, and have decreased body size. Such modifications can impact population dynamics and could lead to changes in life cycle and demography. More specifically, conceptual frameworks predict that global warming will severely threaten tropical ectotherms while temperate ectotherms should resist or even benefit from higher temperatures. However, experimental studies measuring the impacts of future warming trends on temperate ectotherms' life cycle and population persistence are lacking. Here we investigate the impacts of future climates on a model vertebrate ectotherm species using a large-scale warming experiment. We manipulated climatic conditions in 18 seminatural populations over two years to obtain a present climate treatment and a warm climate treatment matching IPCC predictions for future climate. Warmer temperatures caused a faster body growth, an earlier reproductive onset, and an increased voltinism, leading to a highly accelerated life cycle but also to a decrease in adult survival. A matrix population model predicts that warm climate populations in our experiment should go extinct in around 20 y. Comparing our experimental climatic conditions to conditions encountered by populations across Europe, we suggest that warming climates should threaten a significant number of populations at the southern range of the distribution. Our findings stress the importance of experimental approaches on the entire life cycle to more accurately predict population and species persistence in future climates. PMID:26501958

  15. Live Fast, Die Young: Experimental Evidence of Population Extinction Risk due to Climate Change.

    PubMed

    Bestion, Elvire; Teyssier, Aimeric; Richard, Murielle; Clobert, Jean; Cote, Julien

    2015-10-01

    Evidence has accumulated in recent decades on the drastic impact of climate change on biodiversity. Warming temperatures have induced changes in species physiology, phenology, and have decreased body size. Such modifications can impact population dynamics and could lead to changes in life cycle and demography. More specifically, conceptual frameworks predict that global warming will severely threaten tropical ectotherms while temperate ectotherms should resist or even benefit from higher temperatures. However, experimental studies measuring the impacts of future warming trends on temperate ectotherms' life cycle and population persistence are lacking. Here we investigate the impacts of future climates on a model vertebrate ectotherm species using a large-scale warming experiment. We manipulated climatic conditions in 18 seminatural populations over two years to obtain a present climate treatment and a warm climate treatment matching IPCC predictions for future climate. Warmer temperatures caused a faster body growth, an earlier reproductive onset, and an increased voltinism, leading to a highly accelerated life cycle but also to a decrease in adult survival. A matrix population model predicts that warm climate populations in our experiment should go extinct in around 20 y. Comparing our experimental climatic conditions to conditions encountered by populations across Europe, we suggest that warming climates should threaten a significant number of populations at the southern range of the distribution. Our findings stress the importance of experimental approaches on the entire life cycle to more accurately predict population and species persistence in future climates.

  16. An experimental study of toughening and degradation due to microcracking in a ceramic composite

    SciTech Connect

    Han, L.X.; Suresh, S. . Div. of Engineering); Warren, R. )

    1992-02-01

    This paper reports on an experimental investigation that has been carried out to study the effects of controlled microcracking on the fracture resistance of brittle solids. The material chosen as a model system for the experimental study is an aluminum oxide reinforce with 33 vol.% SiC whiskers. The experimental program involves the determination of fracture toughness at room temperature on four-point flexure specimens continuing sharp, through-thickness precracks where different amounts of microcrack damage are introduced a priori at different elevated temperatures and tensile load levels. The room temperature fracture initiation toughness of the pre-damaged material with a controlled amount of small-scale microcracking ahead of the stationary macrocrack is compared and contrasted with that of the undamaged material and the enhancement or reduction in fracture initiation toughness is estimated. Detailed transmission election microscopy of the crack-tip damage zone has been conducted in an attempt to examine the mechanisms of permanent degradation and of microcrack formation.

  17. Theoretical and experimental comparisons of nearfield electrogalvanic fields due to nonlinear polarization layers

    NASA Astrophysics Data System (ADS)

    Kasper, R. G.

    1985-02-01

    Based on completed experimental electric-field scans and the corresponding finite-element field predictions, it appears that the finite-element numerical technique presents a strong analytical tool in calculating the nearfield (within 650 micrometers electric-field distributions about active microcells. This was analytically achieved with the new double membrane finite-element configuration representing nonlinear polarization and by using a local tangent slope (impedance) definition dependent on the local potential difference. The experimental determination of the normal current was realized with a newly developed scanning vibrating electrode technique. The finite-element model utilizes a priori measured uncoupled polarization curves for pure iron and pure copper. The current densities and the electric field intensity was calculated for all the grid points within the electrolyte and on its boundaries. Results appear to indicate that first order anodic mass loss can be predicted using finite-element predicted current density distributions on the anodic surface and the imposition of Faraday's law. The electric-field correlation established for the normal current-density vector provides the confidence to proceed in the evaluation of electric fields associated with pitting and crevice corrosion.

  18. Ecological restructuring in experimental aquatic mesocosms due to the application of diflubenzuron

    USGS Publications Warehouse

    Boyle, Terence P.; Fairchild, James F.; Haverland, Pamela S.; Lebo, Jon A.; Robinson-Wilson, Everett

    1996-01-01

    Diflubenzuron is a chitin-inhibiting insecticide that is registered for use in controlling a multitude of invertebrate pests. The selective mode of action of diflubenzuron provided us with a unique tool for examining the indirect responses of an experimental aquatic ecosystem following direct impacts at the primary consumer (invertebrate) trophic level. Twelve outdoor aquatic mesocosms (0.1 ha each) were randomly assigned to three treatments of diflubenzuron (four mesocosms/treatment): control, monthly (five total 10-μg/L applications), or biweekly (twice monthly; nine total 10-μg/L applications). Direct impacts on invertebrates (numbers and species composition of insects and zooplankton) and indirect impacts on fish (mortality, growth, and reproduction of bluegill sunfish and largemouth bass), phytoplankton (biomass and productivity), and water quality were measured over 16 weeks posttreatment. Both monthly and biweekly treatments of diflubenzuron decreased total numbers (fivefold reduction) and species richness (twofold reduction) and increased dominance (twofold increase) of zooplankton within 4 weeks posttreatment; Cladocerans, Copepods, and Rotifers were all sensitive. Diflubenzuron reduced species richness of emergent insects, which resulted in increased dominance by a few species; however, impacts on emergent insects were confounded by a treatment × time interaction. Direct reductions in invertebrate grazers caused indirect increases in algal biomass. Indirect effects on biomass (50% reduction) and individual weight (50% reduction) of juvenile bluegill occurred because of apparent decreases in invertebrate food resources. No statistically significant impacts were observed on adult bluegill or largemouth bass for the duration of the experiment. Results indicated that diflubenzuron had both direct and indirect impacts on the experimental aquatic ecosystems under the conditions tested.

  19. A case of severe anal injury in an adolescent male due to bestial sexual experimentation.

    PubMed

    Blevins, Roger O

    2009-10-01

    This report delineates a case of anal injury in a 12-year-old boy who gave a detailed history of bestial behavior with a male bulldog. The child described how he had seen this behavior modeled on the internet and subsequently initiated contact with his own dog, causing the dog to penetrate him anally. This type of juvenile bestial behavior with injury has only been reported once previously in the medical literature. Zoophilia, along with a number of other paraphilias, frequently has its onset in the adolescent age group. Adolescents evidencing paraphilic behaviors require thorough psychological evaluation. Spontaneous sexual assault of a human by a canine has never been described in the human or veterinary medical literature, nor is such a thing likely. A clinician involved in evaluating serious ano-genital injury in a child reportedly due to spontaneous canine sexual assault must consider other possible traumatic etiologies including sexual abuse. Investigation in any such case is essential.

  20. Experimental investigation of injectivity alteration due to salt precipitation during CO2 sequestration in saline aquifers

    NASA Astrophysics Data System (ADS)

    Jeddizahed, Javad; Rostami, Behzad

    2016-10-01

    Injection of CO2 into saline aquifers causes the geochemical reaction of rock-fluid and salt precipitation due to the evaporation of water as a physical process. Well injectivity is an important issue in carbon capture and storage (CCS) projects because large volumes of CO2 must be stored for a long time and salt precipitation can significantly reduce injectivity by reducing the permeability. The impact of salt precipitation on the injectivity must therefore be specified in order to maintain the security of CCS projects and enable them to perform at a high level of practicality. The objective of this work is to investigate the influence of the injection rate and brine salinity on injectivity reduction due to evaporation and salt precipitation. In this study, we injected supercritical CO2 into a sandstone rock sample fully saturated with NaCl brine to characterize the salt precipitation induced by the evaporation process. Evaporation is investigated by mass measurement of the water and vapor produced. The extension in time of salt precipitation and the precipitation profile are analyzed by drying rate measurement, Capillary number and Peclet number. The consequences of salt precipitation on injectivity are specified by permeability and relative permeability analysis. The results show that a high drying rate in the early stage of injection induces rapid salt precipitation. The level of salt precipitation increases with salinity, within a permeability reduction range of 21-66%, and decreases with the injection rate, within a permeability reduction range of 43-62%. The relative permeability of CO2 is affected by both the injection rate and salinity.

  1. A comparative evaluation of different DNA vaccine candidates against experimental murine leishmaniasis due to L. major.

    PubMed

    Ahmed, Sami Ben Hadj; Bahloul, Chokri; Robbana, Cyrine; Askri, Souhir; Dellagi, Koussay

    2004-04-16

    Over the past few years, several reports of DNA vaccines against murine cutaneous experimental leishmaniasis came out with promising but sometimes discordant results. The present studies were designed to compare, under similar conditions, the protective effects in the highly susceptible BALB/c mice of DNA vaccine candidates encoding to various Leishmania major antigens. The candidate DNA vaccines encode to the following antigens: LACK, PSA2, Gp63, LeIF and two newly identified p20 and Ribosomal like protein, in addition to different truncated portions of the LACK antigen. The most promising gene was LACK and it is more protective when it is used as a p24 truncated form. Furthermore, the presence of a tandem repeats of immunostimulating sequences (ISS) in the plasmid backbone played an important adjuvant effect in the observed protective effect induced by the DNA vaccine encoding to the LACKp24. Nevertheless, neither of the DNA vaccine candidates was able to mount a full protection in BALB/c mice challenged with a highly virulent L. major strain. Further improvements of the DNA vaccination approach are still needed to design a fully protective vaccine against leishmaniasis. Three directions of investigations are currently explored: DNA vaccines using a cocktail of antigens; Prime/Boost approach; and association of immune modulators with the candidate antigens.

  2. Preliminary experimental observation of nonlocal transport due to SMBI on the J-TEXT tokamak

    NASA Astrophysics Data System (ADS)

    Xiao, Jinshui; Yang, Zhoujun; Zhuang, Ge; Zhang, Chi; Liu, Minghai; State Key Laboratory of Advanced Electromagnetic Engineering; Technology Team

    2014-10-01

    Experimental studies of nonlocal electron heat transport have been carried out in J-TEXT ohmic plasmas exploiting Supersonic Molecular Beam Injection (SMBI) system. By cooling the very edge plasma, a prompt (~1 ms) temperature rise of the plasma core can be induced. For a low density discharge with ne = 1 . 1 ×1019 m-3, the amplitude of ΔTe/Te exceeds 30% at r/a = 0.17 (a is the minor radius). The duration of NLT phenomena is about 10ms, which is comparable with the energy confinement time of J-TEXT. The Te inverse radius in this discharge locates at r/a = 0.33 ~ 0.4 and is outside the q = 1 surface (r/a ~ 0.3), which the latter is estimated from the sawtooth inverse position. As plasma density increases, the nonlocal phenomena decay. Repetitive nonlocal phenomena can be induced by modulated SMBI, which distinctly exhibits the strong dependence on electron density. The critical density is about 1.6 × 1019 m-3.

  3. Experimental Studies of Dynamic Fault Weakening Due to Thermal Pressurization of Pore Fluids

    NASA Astrophysics Data System (ADS)

    Goldsby, David; Tullis, Terry; Platt, John; Okazaki, Keishi

    2016-04-01

    mm, which is in the range predicted by inserting laboratory-determined rock and fluid properties into the formula for L* from Rice [2006]. In another test, steps from 10 μm/s to three different velocities (1.2 mm/s, 2.4 mm/s, and 4.8 mm/s) all fit the Rice solution with values of L* that varied systematically with velocity as predicted by the theory. Deviations from the theoretical prediction occur at displacements larger than 28 mm, since the experimental sample is not a semi-infinite half space, as assumed in the models, and heat is lost to the high-conductivity steel of the sample assembly. To our knowledge, this is the best experimental validation of thermal pressurization to date.

  4. An Experimental Study of the Noise Due to Traffic in a Congested Urban Area

    NASA Astrophysics Data System (ADS)

    Sangeetha, M.; Sankar, P.

    2016-03-01

    Noise pollution in an urban environment is an issue of serious concern in the major cities of India. There are various factors that contribute to the increase of noise levels in urban areas. The intensity of traffic is one of the factors which contributes to a drastic increase in environmental noise. The management of noise pollution has to be considered in the decision making process. In this paper, an attempt is made to study the existing noise level due to the traffic in Velachery which is declared as a sensitive area by the Ministry of Environment and Forestry (MoEF). The noise level data is collected using the MS6710 digital sound meter. The Custic simulation software version 3.2 is used for finding the propagation of noise. The spatial patterns of measurement were also calculated, in the sub-urban area of Velachery, Chennai, Tamilnadu, India. A means of transmitting this data to vehicles moving in the area, through a wireless medium is simulated using NCTUns 6.0 (network simulator), to enable drivers to understand the environmental conditions. A hardware was also designed which can be used to transmit and receive the noise data using the Zigbee module. A noise transmitting station is placed at a junction, so that it can transmit this noise data to the receivers which are fitted inside the vehicles.

  5. [Experimental electric and biochemical data on ventricular fibrillation due to ischemia].

    PubMed

    Arnulf, G

    1976-08-01

    The author presents the results of prolonged research into ventricular fibrillation during myocardial ischaemia, both from the electrocardiographic and biochemical standpoints. - He emphasises the successive tonic and atonic features of VF due to ischaemia, and the difference between the fibrillation in an ischaemic area and in a control area. The most original concept is that there is often a difference between the onset of VF in an ischaemic zone and in a control zone. This study has been carried out with both acute and progressive ischaemia. - The biochemical studies were carried out on blood samples taken from the origin of the coronary arteries, the coronary veins, and from the saphenous veins. An important finding was the definite increase in the potassium level of the coronary venous blood in proportion to the degree of ischaemia; the sodium level showed little change, and if anything tended to fall. But the most important and distinctive finding was that at the onset of VF the sodium and potassium concentrations in the coronary venous blood suddenly increase. As the VF continues, there is a progressive increase in lactic acid and a fall in pH, which is maximal at the onset of the VF. These findings are valid under normothermic conditions, and when there is no extracorporeal circulation. - The physiopathological and practical implications of these facts are discussed.

  6. Experimental observations of turbulent mixing due to Kelvin-Helmholtz instability on the OMEGA Laser Facility

    SciTech Connect

    Smalyuk, V. A.; Hansen, J. F.; Hurricane, O. A.; Langstaff, G.; Martinez, D.; Park, H.-S.; Raman, K.; Remington, B. A.; Robey, H. F.; Schilling, O.; Wallace, R.; Elbaz, Y.; Shimony, A.; Shvarts, D.; Di Stefano, C.; Drake, R. P.; Marion, D.; Krauland, C. M.; Kuranz, C. C.

    2012-09-15

    Shear-flow, Kelvin-Helmholtz (KH) turbulent mixing experiments were performed on the OMEGA Laser Facility [Boehly et al., Opt. Commun. 133, 495 (1997)] in which laser-driven shock waves propagated through a low-density plastic foam placed on top of a higher-density plastic foil. The plastic foil was comprised a thin iodine-doped plastic tracer layer bonded on each side to an undoped density-matched polyamide-imide plastic. Behind the shock front, lower-density foam plasma flowed over the higher-density plastic plasma, such that the interface between the foam and plastic was KH unstable. The initial perturbations consisted of pre-imposed, sinusoidal 2D perturbations, and broadband 3D perturbations due to surface roughness at the interface between the plastic and foam. KH instability growth was measured using side-on radiography with a point-projection 5-keV vanadium backlighter. Time-integrated images were captured on D-8 x-ray film. Spatial density profiles of iodine-doped plastic mixed with foam were inferred using x-ray radiographs. The mixing layer ensuing from the KH instability with layer width up to {approx}100 {mu}m was observed at a location {approx}1 mm behind the shock front. The measured mixing layer width was in good agreement with predictions based on a simple self-similar model of KH instability growth using an estimate of the shear velocity obtained from numerical simulations of the experiments.

  7. Colon Necrosis Due to Sodium Polystyrene Sulfonate with and without Sorbitol: An Experimental Study in Rats.

    PubMed

    Ayoub, Isabelle; Oh, Man S; Gupta, Raavi; McFarlane, Michael; Babinska, Anna; Salifu, Moro O

    2015-01-01

    Based on a single rat study by Lillemoe et al, the consensus has been formed to implicate sorbitol rather than sodium polystyrene sulfonate (SPS) as the culprit for colon necrosis in humans treated with SPS and sorbitol. We tested the hypothesis that colon necrosis by sorbitol in the experiment was due to the high osmolality and volume of sorbitol rather than its chemical nature. 26 rats underwent 5/6 nephrectomy. They were divided into 6 groups and given enema solutions under anesthesia (normal saline, 33% sorbitol, 33% mannitol, SPS in 33% sorbitol, SPS in normal saline, and SPS in distilled water). They were sacrificed after 48 hours of enema administration or earlier if they were very sick. The gross appearance of the colon was visually inspected, and then sliced colon tissues were examined under light microscopy. 1 rat from the sorbitol and 1 from the mannitol group had foci of ischemic colonic changes. The rats receiving SPS enema, in sorbitol, normal saline, distilled water, had crystal deposition with colonic necrosis and mucosal erosion. All the rats not given SPS survived until sacrificed at 48 h whereas 11 of 13 rats that received SPS in sorbitol, normal saline or distilled water died or were clearly dying and sacrificed sooner. There was no difference between sorbitol and mannitol when given without SPS. In a surgical uremic rat model, SPS enema given alone or with sorbitol or mannitol seemed to cause colon necrosis and high mortality rate, whereas 33% sorbitol without SPS did not.

  8. Inactivation of Pulmonary Surfactant Due to Serum-Inhibited Adsorption and Reversal by Hydrophilic Polymers: Experimental

    PubMed Central

    Taeusch, H. William; de la Serna, Jorge Bernardino; Perez-Gil, Jesus; Alonso, Coralie; Zasadzinski, Joseph A.

    2005-01-01

    The rate of change of surface pressure, π, in a Langmuir trough following the deposition of surfactant suspensions on subphases containing serum, with or without polymers, is used to model a likely cause of surfactant inactivation in vivo: inhibition of surfactant adsorption due to competitive adsorption of surface active serum proteins. Aqueous suspensions of native porcine surfactant, organic extracts of native surfactant, and the clinical surfactants Curosurf, Infasurf, and Survanta spread on buffered subphases increase the surface pressure, π, to ∼40 mN/m within 2 min. The variation with concentration, temperature, and mode of spreading confirmed Brewster angle microscopy observations that subphase to surface adsorption of surfactant is the dominant form of surfactant transport to the interface. However (with the exception of native porcine surfactant), similar rapid increases in π did not occur when surfactants were applied to subphases containing serum. Components of serum are surface active and adsorb reversibly to the interface increasing π up to a concentration-dependent saturation value, πmax. When surfactants were applied to subphases containing serum, the increase in π was significantly slowed or eliminated. Therefore, serum at the interface presents a barrier to surfactant adsorption. Addition of either hyaluronan (normally found in alveolar fluid) or polyethylene glycol to subphases containing serum reversed inhibition by restoring the rate of surfactant adsorption to that of the clean interface, thereby allowing surfactant to overcome the serum-induced barrier to adsorption. PMID:15923228

  9. Inactivation of pulmonary surfactant due to serum-inhibited adsorption and reversal by hydrophilic polymers: experimental.

    PubMed

    Taeusch, H William; Bernardino de la Serna, Jorge; Perez-Gil, Jesus; Alonso, Coralie; Zasadzinski, Joseph A

    2005-09-01

    The rate of change of surface pressure, pi, in a Langmuir trough following the deposition of surfactant suspensions on subphases containing serum, with or without polymers, is used to model a likely cause of surfactant inactivation in vivo: inhibition of surfactant adsorption due to competitive adsorption of surface active serum proteins. Aqueous suspensions of native porcine surfactant, organic extracts of native surfactant, and the clinical surfactants Curosurf, Infasurf, and Survanta spread on buffered subphases increase the surface pressure, pi, to approximately 40 mN/m within 2 min. The variation with concentration, temperature, and mode of spreading confirmed Brewster angle microscopy observations that subphase to surface adsorption of surfactant is the dominant form of surfactant transport to the interface. However (with the exception of native porcine surfactant), similar rapid increases in pi did not occur when surfactants were applied to subphases containing serum. Components of serum are surface active and adsorb reversibly to the interface increasing pi up to a concentration-dependent saturation value, pi(max). When surfactants were applied to subphases containing serum, the increase in pi was significantly slowed or eliminated. Therefore, serum at the interface presents a barrier to surfactant adsorption. Addition of either hyaluronan (normally found in alveolar fluid) or polyethylene glycol to subphases containing serum reversed inhibition by restoring the rate of surfactant adsorption to that of the clean interface, thereby allowing surfactant to overcome the serum-induced barrier to adsorption.

  10. Analysis of Asymmetric Aircraft Aerodynamics Due to an Experimental Wing Glove

    NASA Technical Reports Server (NTRS)

    Hartshorn, Fletcher

    2011-01-01

    Aerodynamic analysis on a business jet with a wing glove attached to one wing is presented and discussed. If a wing glove is placed over a portion of one wing, there will be asymmetries in the aircraft as well as overall changes in the forces and moments acting on the aircraft. These changes, referred to as deltas, need to be determined and quantified to make sure the wing glove does not have a drastic effect on the aircraft flight characteristics. TRANAIR, a non-linear full potential solver was used to analyze a full aircraft, with and without a glove, at a variety of flight conditions and angles of attack and sideslip. Changes in the aircraft lift, drag and side force, along with roll, pitch and yawing moment are presented. Span lift and moment distributions are also presented for a more detailed look at the effects of the glove on the aircraft. Aerodynamic flow phenomena due to the addition of the glove and its fairing are discussed. Results show that the glove used here does not present a drastic change in forces and moments on the aircraft, but an added torsional moment around the quarter-chord of the wing may be a cause for some structural concerns.

  11. Analysis of Asymmetric Aircraft Aerodynamics Due to an Experimental Wing Glove

    NASA Technical Reports Server (NTRS)

    Hartshorn, Fletcher

    2011-01-01

    Aerodynamic computational fluid dynamics analysis of a wing glove attached to one wing of a business jet is presented and discussed. A wing glove placed on only one wing will produce asymmetric aerodynamic effects that will result in overall changes in the forces and moments acting on the aircraft. These changes, referred to as deltas, need to be determined and quantified to ensure that the wing glove does not have a significant effect on the aircraft flight characteristics. TRANAIR (Calmar Research Corporation, Cato, New York), a nonlinear full potential solver, and Star-CCM+ (CD-adapco, Melville, New York), a finite volume full Reynolds-averaged Navier-Stokes computational fluid dynamics solver, are used to analyze a full aircraft with and without the glove at a variety of flight conditions, aircraft configurations, and angles of attack and sideslip. Changes in the aircraft lift, drag, and side force along with roll, pitch, and yaw are presented. Span lift and moment distributions are also presented for a more detailed look at the effects of the glove on the aircraft. Aerodynamic flow phenomena due to the addition of the glove are discussed. Results show that the glove produces only small changes in the aerodynamic forces and moments acting on the aircraft, most of which are insignificant.

  12. Variation in aerosol nucleation and growth in coal-fired power plant plumes due to background aerosol, meteorology and emissions: sensitivity analysis and parameterization.

    NASA Astrophysics Data System (ADS)

    Stevens, R. G.; Lonsdale, C. L.; Brock, C. A.; Reed, M. K.; Crawford, J. H.; Holloway, J. S.; Ryerson, T. B.; Huey, L. G.; Nowak, J. B.; Pierce, J. R.

    2012-04-01

    New-particle formation in the plumes of coal-fired power plants and other anthropogenic sulphur sources may be an important source of particles in the atmosphere. It remains unclear, however, how best to reproduce this formation in global and regional aerosol models with grid-box lengths that are 10s of kilometres and larger. The predictive power of these models is thus limited by the resultant uncertainties in aerosol size distributions. In this presentation, we focus on sub-grid sulphate aerosol processes within coal-fired power plant plumes: the sub-grid oxidation of SO2 with condensation of H2SO4 onto newly-formed and pre-existing particles. Based on the results of the System for Atmospheric Modelling (SAM), a Large-Eddy Simulation/Cloud-Resolving Model (LES/CRM) with online TwO Moment Aerosol Sectional (TOMAS) microphysics, we develop a computationally efficient, but physically based, parameterization that predicts the characteristics of aerosol formed within coal-fired power plant plumes based on parameters commonly available in global and regional-scale models. Given large-scale mean meteorological parameters, emissions from the power plant, mean background condensation sink, and the desired distance from the source, the parameterization will predict the fraction of the emitted SO2 that is oxidized to H2SO4, the fraction of that H2SO4 that forms new particles instead of condensing onto preexisting particles, the median diameter of the newly-formed particles, and the number of newly-formed particles per kilogram SO2 emitted. We perform a sensitivity analysis of these characteristics of the aerosol size distribution to the meteorological parameters, the condensation sink, and the emissions. In general, new-particle formation and growth is greatly reduced during polluted conditions due to the large preexisting aerosol surface area for H2SO4 condensation and particle coagulation. The new-particle formation and growth rates are also a strong function of the

  13. Damaged Neocortical Perineuronal Nets Due to Experimental Focal Cerebral Ischemia in Mice, Rats and Sheep.

    PubMed

    Härtig, Wolfgang; Mages, Bianca; Aleithe, Susanne; Nitzsche, Björn; Altmann, Stephan; Barthel, Henryk; Krueger, Martin; Michalski, Dominik

    2017-01-01

    As part of the extracellular matrix (ECM), perineuronal nets (PNs) are polyanionic, chondroitin sulfate proteoglycan (CSPG)-rich coatings of certain neurons, known to be affected in various neural diseases. Although these structures are considered as important parts of the neurovascular unit (NVU), their role during evolution of acute ischemic stroke and subsequent tissue damage is poorly understood and only a few preclinical studies analyzed PNs after acute ischemic stroke. By employing three models of experimental focal cerebral ischemia, this study was focused on histopathological alterations of PNs and concomitant vascular, glial and neuronal changes according to the NVU concept. We analyzed brain tissues obtained 1 day after ischemia onset from: (a) mice after filament-based permanent middle cerebral artery occlusion (pMCAO); (b) rats subjected to thromboembolic MACO; and (c) sheep at 14 days after electrosurgically induced focal cerebral ischemia. Multiple fluorescence labeling was applied to explore simultaneous alterations of NVU and ECM. Serial mouse sections labeled with the net marker Wisteria floribunda agglutinin (WFA) displayed largely decomposed and nearly erased PNs in infarcted neocortical areas that were demarcated by up-regulated immunoreactivity for vascular collagen IV (Coll IV). Subsequent semi-quantitative analyses in mice confirmed significantly decreased WFA-staining along the ischemic border zone and a relative decrease in the directly ischemia-affected neocortex. Triple fluorescence labeling throughout the three animal models revealed up-regulated Coll IV and decomposed PNs accompanied by activated astroglia and altered immunoreactivity for parvalbumin, a calcium-binding protein in fast-firing GABAergic neurons which are predominantly surrounded by neocortical PNs. Furthermore, ischemic neocortical areas in rodents simultaneously displayed less intense staining of WFA, aggrecan, the net components neurocan, versican and the cartilage link

  14. Effect of sulphated polysaccharides on erythrocyte changes due to oxidative and nitrosative stress in experimental hyperoxaluria.

    PubMed

    Veena, C K; Josephine, A; Preetha, S P; Varalakshmi, P

    2007-12-01

    Kidney stones are known to haunt humanity for centuries and increase in oxalate is a predominant risk factor for stone formation. The present study was initiated with a notion to study the oxidative and nitrosative stress on erythrocytes under oxalate stress and the putative role of sulphated polysaccharides. Hyperoxaluria was induced in two groups by the administration of 0.75% ethylene glycol in drinking water for 28 days and one of them was treated with sulphated polysaccharides from Fucus vesiculosus from the 8th day to the end of the experimental period of 28 days at a dose of 5 mg/kg body weight subcutaneously. Control and drug control (sulphated polysaccharides alone) were also included in the study. Glycolic and glyoxylic acid levels of urine were analyzed as an index of hyperoxaluria. The plasma enzymic markers of cellular integrity, redox status of red blood cells, osmotic fragility, and (14)C-oxalate binding were investigated. Urine and plasma nitric oxide metabolites, expression of inducible nitric oxide synthase protein, and mRNA were assessed in kidney to evaluate the nitrosative stress. Increased levels of glycolic and glyoxylic acid in urine indicated the prevalence of hyperoxaluria in ethylene glycol-administered groups. Plasma aspartate and alanine transaminase were not altered, but alkaline phosphatase and lactate dehydrogenase of hyperoxaluric group were increased indicating tissue damage. Activities of antioxidant enzymes were decreased, whereas erythrocyte membrane lipid peroxidation was increased in hyperoxaluric rats. Moreover, an altered fragility with an increase in oxalate binding activity was observed in hyperoxaluric group. Increase in nitric oxide metabolites levels in urine and plasma along with an increase in expression of inducible nitric oxide synthase protein and mRNA in kidney were observed in hyperoxaluric rats. Administration of sulphated polysaccharides to hyperoxaluric rats averted the abnormal increase in urinary glycolic

  15. Colon Necrosis Due to Sodium Polystyrene Sulfonate with and without Sorbitol: An Experimental Study in Rats

    PubMed Central

    Ayoub, Isabelle; Oh, Man S.; Gupta, Raavi; McFarlane, Michael; Babinska, Anna; Salifu, Moro O.

    2015-01-01

    Introduction Based on a single rat study by Lillemoe et al, the consensus has been formed to implicate sorbitol rather than sodium polystyrene sulfonate (SPS) as the culprit for colon necrosis in humans treated with SPS and sorbitol. We tested the hypothesis that colon necrosis by sorbitol in the experiment was due to the high osmolality and volume of sorbitol rather than its chemical nature. Methods 26 rats underwent 5/6 nephrectomy. They were divided into 6 groups and given enema solutions under anesthesia (normal saline, 33% sorbitol, 33% mannitol, SPS in 33% sorbitol, SPS in normal saline, and SPS in distilled water). They were sacrificed after 48 hours of enema administration or earlier if they were very sick. The gross appearance of the colon was visually inspected, and then sliced colon tissues were examined under light microscopy. Results 1 rat from the sorbitol and 1 from the mannitol group had foci of ischemic colonic changes. The rats receiving SPS enema, in sorbitol, normal saline, distilled water, had crystal deposition with colonic necrosis and mucosal erosion. All the rats not given SPS survived until sacrificed at 48 h whereas 11 of 13 rats that received SPS in sorbitol, normal saline or distilled water died or were clearly dying and sacrificed sooner. There was no difference between sorbitol and mannitol when given without SPS. Conclusions In a surgical uremic rat model, SPS enema given alone or with sorbitol or mannitol seemed to cause colon necrosis and high mortality rate, whereas 33% sorbitol without SPS did not. PMID:26413782

  16. Experimental response of Salix cuttings to different flow regimes due to human activities

    NASA Astrophysics Data System (ADS)

    Gorla, Lorenzo; Signarbieux, Constant; Turberg, Pascal; Buttler, Alexandre; Perona, Paolo

    2014-05-01

    Hydropower production and other human activities change the natural flow regime of rivers, in turn impacting the riparian environment. The main challenge in order to define eco-sustainable flows is to quantify the effects in terms of geomorphology and ecosystem adaptation. We present 2-years controlled experiments to investigate riparian vegetation (Salix Viminalis) response to forced water table changing dynamics, from one water regime to another, in a temperate region (Switzerland). Three synthetic flow regimes have been simulated and applied to three batteries of Salix cuttings growing outdoor within plastic pots, each about 1 meter tall. In 2012 one treatment simulated a minimal flow policy for small run-of-river hydropower plants, which drastically impacts the low and the medium-low components of the hydrograph, but not the extremes. In 2013 we confirmed and completed some of 2012 results, by reproducing typical hydropeaking effects due to dam management and focusing on daily water table variations and offsets. For both the seasons, after an initial period where all pots undergone the same oscillations in order to uniform the plants initial conditions, the experiment started, and the water dynamic was changed. Cuttings transitory response dynamics has been quantified by continuous sap flow and water potential measurements, and by regularly collecting growth parameters, as well as leaves photosynthesis, fluorescence, and pictures of each plant. At the end of the experiment, all cuttings were carefully removed and the both above and below ground biomass analyzed in detail. Particularly, the 3D root structure was obtained by High Resolution Computer Tomography. Our analyses revealed a clear dependence between roots distribution and water regime reflecting the need for adaptation, in agreement with field observations of Pasquale et al. (2012). In particular, an initial strong difference in terms of stress and growth performances was then followed by a later

  17. Transcutaneous immunization as preventative and therapeutic regimens to protect against experimental otitis media due to nontypeable Haemophilus influenzae

    PubMed Central

    Novotny, L A; Clements, J D; Bakaletz, L O

    2011-01-01

    We have developed three nontypeable Haemophilus influenzae (NTHI) adhesin-derived immunogens that are significantly efficacious against experimental otitis media (OM) due to NTHI when delivered parenterally. We now expanded our preventative immunization strategies to include transcutaneous immunization (TCI) as a less invasive, but potentially equally efficacious, regimen to prevent OM due to NTHI. Additionally, we examined the potential of TCI as a therapeutic immunization regimen to resolve ongoing experimental OM. Preventative immunization with NTHI outer membrane protein (OMP) P5- and type IV pilus-targeted immunogens, delivered with the adjuvant LT(R192G-L211A), induced significantly earlier clearance of NTHI from the nasopharynges and middle ears of challenged chinchillas compared with receipt of immunogen or adjuvant alone. Moreover, therapeutic immunization resulted in significant resolution of established NTHI biofilms from the middle ear space of animals compared with controls. These data advocate TCI with the adhesin-directed immunogens as an efficacious regimen for prevention and resolution of experimental NTHI-induced OM. PMID:21326197

  18. Experimental observation of increased threshold electric field for runaway generation due to synchrotron radiation losses in the FTU tokamak

    SciTech Connect

    Martin-Solis, Jose Ramon; Sanchez, Raul; Esposito, Basilio

    2010-01-01

    The threshold electric field for runaway generation has been investigated during runaway suppression experiments by means of electron-cyclotron-resonance heating in the flattop phase of FTU discharges. Runaway suppression has been experimentally found to occur at electric fields substantially larger than those predicted by the relativistic collisional theory of runaway generation, E{sub R} = n{sub e}e{sup 3}ln{Lambda}/4{pi}{var_epsilon}{sub 0}{sup 2}m{sub e}c{sup 2}. These experimental results are consistent with an increase of the critical electric field due to the electron synchrotron radiation losses. No runaway electrons are found in FTU experiments below the radiation threshold. These results support evidence for a new threshold electric field for runaway generation that accounts for the effect of the synchrotron losses, and which should be considered when making predictions on runaway generation and mitigation in devices such as ITER.

  19. Experimental evidence of the increased transport due to the wall bounded magnetic drift in low temperature plasma

    SciTech Connect

    Gaboriau, F. Baude, R.; Hagelaar, G. J. M.

    2014-05-26

    This paper presents experimental results on plasma transport across the magnetic field (B) in magnetized low-temperature plasma sources. Due to the presence of chamber walls, this transport can be complex even in a non-turbulent regime. In particular, in configurations without cylindrical symmetry, the magnetic drifts tend to be bounded by the chamber walls, thereby inducing plasma asymmetry and reducing magnetic confinement. In this work, we measure electron and ion current densities at metal chamber walls bounding a rectangular magnetic filter and demonstrate that these current densities are asymmetrically nonuniform. We also provide an experimental confirmation of model predictions of increased cross-field electron transport in such filter configuration, scaling as 1/B rather than the classical 1/B{sup 2} scaling.

  20. Reverse and pseudo redistribution of thallium-201 in healed myocardial infarction and normal and negative thallium-201 washout in ischemia due to background oversubtraction

    SciTech Connect

    Lear, J.L.; Raff, U.; Jain, R.

    1988-09-15

    While the interpolative background subtraction used in quantitative planar thallium scanning can significantly overestimate the background overlying the heart, the effects of background oversubtraction on quantitative analysis have not been well defined. A mathematical model that relates myocardial washout determined using interpolative background subtraction to true myocardial washout is presented. The model was validated using phantoms and applied to myocardial and pulmonary thallium kinetic data in 100 patients, 85 with and 15 without coronary artery disease. The model showed that when using interpolative background subtraction, measured washout equals true washout in normally perfused myocardium; however, depending on the relation between myocardial and pulmonary thallium clearance, myocardial washout in ischemic regions and areas of infarction can be substantially over- or underestimated. Based on generally accepted quantitative criteria, this incorrect washout determination can at times lead to misdiagnosis of infarction as ischemia and ischemia as normally perfused tissue. It can also cause both ''reverse redistribution'' and ''pseudo redistribution'' of thallium in myocardial infarction in the absence of a physiologic basis.

  1. EVIDENCE OF FEED CONTAMINATION DUE TO SAMPLE HANDLING AND PREPARATION DURING A MASS BALANCE STUDY OF DIOXINS IN LACTATING COWS IN BACKGROUND CONDITIONS

    EPA Science Inventory

    In 1997, the United States (US) Environmental Protection Agency (EPA) conducted a mass balance study of polychlorinated dibenzo-p-dioxins (CDDs) and dibenzofurans (CDFs) in lactating cows in background conditions. The field portion of the study occurred at the US Department of A...

  2. EVIDENCE OF FEED CONTAMINATION DUE TO SAMPLE HANDLING AND PREPARATION DURING A MASS BALANCE STUDY OF DIOXINS IN LACTATING COWS IN BACKGROUND CONDITIONS

    EPA Science Inventory

    In 1997, the United States (US) Environmental Protection Agency (EPA) conducted a mass balance study of polychlorinated dibenzo-p-dioxins (CDDs) and dibenzofurans (CDFs) in lactating cows in background conditions. The field portion of the study occurred at the US Department of A...

  3. Volume Changes of Experimental Carotid Sidewall Aneurysms Due to Embolization with Liquid Embolic Agents: A Multidetector CT Angiography Study

    SciTech Connect

    Dudeck, O. Okuducu, A. F.; Jordan, O.; Tesmer, K.; Pech, M.; Weigang, E.; Ruefenacht, D. A.; Doelker, E.; Felix, R.

    2006-12-15

    Iodine-containing polyvinyl alcohol polymer (I-PVAL) is a novel precipitating liquid embolic that allows for artifact-free evaluation of CT angiography (CTA). As accurate aneurysm volumetry can be performed with multidetector CTA, we determined volumes of experimental aneurysms before, immediately after, and 4 weeks after embolization of 14 porcine experimental carotid sidewall aneurysms with this liquid embolic. An automated three-dimensional software measurement tool was used for volumetric analysis of volume-rendering CTA data. Furthermore, intra-aneurysmal pressure changes during liquid embolization were measured in four silicone aneurysms and potential polymer volume changes within 4 weeks were assessed in vitro. Liquid embolic injection was performed during temporary balloon occlusion of the aneurysm neck, resulting in a mean occlusion rate of 98.3%. Aneurysms enlarged significantly during embolization by 61.1 {+-} 28.9%, whereas a significant shrinkage of 5.6 {+-} 2.7% was observed within the follow-up period. Histologic analysis revealed an inflammatory foreign body reaction with partial polymer degradation. In silicone aneurysm models, intra-aneurysmal pressure remained unchanged during liquid embolic injection, whereas balloon inflation resulted in a mean pressure increase of 31.2 {+-} 0.7%. No polymer shrinkage was observed in vitro. The aneurysm enlargement noted was presumably due to pressure elevation after balloon inflation, which resulted in dilatation of the weak venous wall of the newly constructed aneurysm-another shortcoming of this experimental aneurysm model. The volume decrease after 4 weeks expressed partial polymer degradation.

  4. Long-length, long-lived flow-shear stabilized Z-pinches: Background and Experimental plans for scaling studies

    NASA Astrophysics Data System (ADS)

    Nelson, B. A.; Shumlak, U.; Golingo, R. P.; Claveau, E. L.; McLean, H. S.; Schmidt, A. E.

    2015-11-01

    The ZaP experiment produces long-lived sheared-flow-stabilized Z-pinch plasmas up to 126 cm in length for several flow-through times, and up to thousands of Alfvén times. Experimental measurements of the magnetic structure along the full length of the plasma column show an axially uniform Z-pinch plasma during the observed quiescent period. Interferometry, fast-framing images, and Rogowskii coils corroborate the existence of a pinched plasma during this quiescent period of time. Detailed two-dimensional non-linear magnetohydrodynamic (MHD) calculations have been performed showing the formation and assembly of long-length, long-lived Z-pinches. Experimentally-observed plasma lifetimes and velocity-shear profiles are shown to be consistent with calculations of viscous-damping timescales based on the measured plasma parameters. A newly-funded ARPA-E ALPHA project, the Fusion Z-pinch Experiment ``FuZE'' is being constructed at the University of Washington, in collaboration with the Lawrence Livermore National Laboratory. FuZE will study scaling and stability of the successful ZaP experiment to higher pinch currents. The FuZE experimental design, goals, and plans, based on ZaP experimental results, will be presented.

  5. Increased heat transfer to elliptical leading edges due to spanwise variations in the freestream momentum: Numerical and experimental results

    NASA Technical Reports Server (NTRS)

    Rigby, D. L.; Vanfossen, G. J.

    1992-01-01

    A study of the effect of spanwise variation in momentum on leading edge heat transfer is discussed. Numerical and experimental results are presented for both a circular leading edge and a 3:1 elliptical leading edge. Reynolds numbers in the range of 10,000 to 240,000 based on leading edge diameter are investigated. The surface of the body is held at a constant uniform temperature. Numerical and experimental results with and without spanwise variations are presented. Direct comparison of the two-dimensional results, that is, with no spanwise variations, to the analytical results of Frossling is very good. The numerical calculation, which uses the PARC3D code, solves the three-dimensional Navier-Stokes equations, assuming steady laminar flow on the leading edge region. Experimentally, increases in the spanwise-averaged heat transfer coefficient as high as 50 percent above the two-dimensional value were observed. Numerically, the heat transfer coefficient was seen to increase by as much as 25 percent. In general, under the same flow conditions, the circular leading edge produced a higher heat transfer rate than the elliptical leading edge. As a percentage of the respective two-dimensional values, the circular and elliptical leading edges showed similar sensitivity to span wise variations in momentum. By equating the root mean square of the amplitude of the spanwise variation in momentum to the turbulence intensity, a qualitative comparison between the present work and turbulent results was possible. It is shown that increases in leading edge heat transfer due to spanwise variations in freestream momentum are comparable to those due to freestream turbulence.

  6. Experimental Observations and Discrete Element Simulations of Bed Force Anomalies due to Force Chains in Dense Granular flows

    NASA Astrophysics Data System (ADS)

    Estep, J.; Dufek, J.

    2012-12-01

    Surficial flows on volcanic edifices are often comprised of high concentrations of granular materials either derived from juvenile eruptive material or material sourced from an unstable edifice. Although much attention has been given to granular flow mobility, the physics that govern their internal behavior are still poorly understood. Our work builds on previous research showing that force chains transmit extreme localized forces to the substrates of free surface granular flows, and combines experimental and computational approaches to further investigate the forces at the bed of a simplified granular flow. A photoelastic experimental approach is used to resolve discrete forces in the granular flows, while discrete element model (DEM) simulations reproduce the experimental flows. Input parameters for the DEM are derived from measurable physical material properties, and DEM simulations using properties of natural materials corroborate experimental results. The DEM results show particular sensitivity to values prescribed for contact stiffness, which is in contrast with previous reports indicating that stiffness values have insignificant influence on flow behavior. The forces at the bed generated by force chain structures can transiently greatly exceed (by several 100%) the bed forces predicted from continuum approaches, and natural materials are more prone to excessive bed forces than photoelastic materials due to their larger contact stiffnesses. By varying the ratios of a bidisperse grain size population, continuing experiments investigate how further complexity in the granular flow regime influences force transmission via force chains. This work suggests that force chain activity may play an important role in the bed physics of dense volcanic flows by influencing substrate entrainment.

  7. Clinical and experimental keratitis due to Curvularia lunata (Wakker) Boedijn var. aeria (Batista, Lima and Vasconcelos) Ellis.

    PubMed

    Agrawal, P K; Lal, B; Shukla, P K; Khan, Z A; Srivastava, O P

    1982-09-01

    A case of mycotic keratitis due to Curvularia lunata var. aeria is reported for the first time from India. Direct microscopic examination of the corneal scrapings in KOH (50 g1(-1)), stained with lactophenol cotton blue, revealed brown septate hyphae and the cultures were found positive for fungus. It was identified as C. lunata (Wakker) Boedijn var. aeria (Batista, Lima and Vasconcelos) Ellis (IMI 253204) and its growth was better at 28 degrees C than at 37 degrees C. In vitro, the fungus was most sensitive to amphotericin B followed by miconazole nitrate, clotrimazole and triphenyltin isoselenocyanate 4-picoline which had the same activity. Lactones were least active and tolciclate and arnebins and inactive. The fungus produced experimental keratomycosis in the rabbit cornea and the infection severity as well as histopathological changes were more pronounced in rabbits that received penicillin, streptomycin and cortisone.

  8. Experimental investigation in plasma relaxation by using a compact coaxial magnetized plasma gun in a background plasma

    NASA Astrophysics Data System (ADS)

    Zhang, Yue; Lynn, Alan; Gilmore, Mark; Hsu, Scott

    2012-10-01

    A compact coaxial plasma gun is employed for experimental studies of plasma relaxation process being conducted in the HELCAT device at UNM. These studies will advance the knowledge of basic plasma physics in the areas of magnetic relaxation and space and astrophysical plasmas, including the evolution of active galactic jets/radio lobes. The gun is powered by a 120pF ignitron-switched capacitor bank which is operated in a range of 5 - 10kV. Multiple diagnostics are employed to investigate plasma relaxation process. Magnetized Argon plasma bubbles with velocities 1.2Cs and densities 10e20 m-3 have been achieved. Different distinct regimes of operation with qualitatively different dynamics are identified by fast CCD camera images, with the parameter lambda determining the operation regime. Additionally, a B-dot probe array is employed to measure the spatial toroidal and poloidal magnetic flux evolution to identify detached plasma bubble configurations. Experimental data and analysis will be presented.

  9. Inbred Strains Derived from Feral Mice Reveal New Pathogenic Mechanisms of Experimental Leishmaniasis Due to Leishmania major

    PubMed Central

    Babay, Besma E. C.; Louzir, Hechmi; Kebaïer, Chahnaz; Boubaker, Samir; Dellagi, Koussay; Cazenave, Pierre-André

    2004-01-01

    Two inbred mouse strains, derived from feral founders, are susceptible to experimental leishmaniasis due to Leishmania major and support a disease of a severity intermediate between those observed in strains C57BL/6 and BALB/c. Mice of the MAI strain develop a severe, nonhealing, but nonfatal disease with no resistance to a secondary parasite challenge. The immunological responses showed a TH2 dominance characterized by an early peak of interleukin-4 (IL-4) and IL-13. However, neutralization of IL-4, which leads to a resistance phenotype in BALB/c mice, has no effect on disease progression in MAI mice. Mice of strain PWK develop a protracted but self-healing disease, characterized by a mixed TH1-plus-TH2 pattern of immune responses in which IL-10 plays an aggravating role, and acquire resistance to a secondary challenge. These features are close to those observed in human cutaneous leishmaniasis due to L. major and make PWK mice a suitable model for the human disease. PMID:15271920

  10. Inbred strains derived from feral mice reveal new pathogenic mechanisms of experimental leishmaniasis due to Leishmania major.

    PubMed

    Babay, Besma E C; Louzir, Hechmi; Kebaïer, Chahnaz; Boubaker, Samir; Dellagi, Koussay; Cazenave, Pierre-André

    2004-08-01

    Two inbred mouse strains, derived from feral founders, are susceptible to experimental leishmaniasis due to Leishmania major and support a disease of a severity intermediate between those observed in strains C57BL/6 and BALB/c. Mice of the MAI strain develop a severe, nonhealing, but nonfatal disease with no resistance to a secondary parasite challenge. The immunological responses showed a TH2 dominance characterized by an early peak of interleukin-4 (IL-4) and IL-13. However, neutralization of IL-4, which leads to a resistance phenotype in BALB/c mice, has no effect on disease progression in MAI mice. Mice of strain PWK develop a protracted but self-healing disease, characterized by a mixed TH1-plus-TH2 pattern of immune responses in which IL-10 plays an aggravating role, and acquire resistance to a secondary challenge. These features are close to those observed in human cutaneous leishmaniasis due to L. major and make PWK mice a suitable model for the human disease.

  11. A low dose-fractionation shceme for the radiotherapy of carcinoma of the bladder. Experimental background and preliminary results.

    PubMed

    Littbrand, B; Edsmyr, F; Révész, L

    1975-01-01

    Experimental observations are described which form the basis of a low dose-fractionation scheme designed in an attempt to circumvent the problem presented for radiotherapy by the particular radioresistance of poorly oxygenated cells. In a preliminary investigation the scheme was tested in the treatment of carcinoma of the bladder. A total of 45 patients were included in the trial, randomized to be treated according to either of two fractionation schemes. Scheme I : 100 rad 3 times a day, 5 days a week, a total tumor dose of 8 400 rad, 2 weeks of rest in middle of the treatment period. Scheme II : 200 rad once a day, 5 days a week, a total tumor dose of 6 400 rad, 2 weeks of rest in the middle of the treatment period. The results suggest an improved therapeutic ratio with Scheme I in comparison to Scheme II.

  12. RP 59500 prophylaxis of experimental endocarditis due to erythromycin-susceptible and -resistant isogenic pairs of viridans group streptococci.

    PubMed Central

    L'Hériteau, F; Entenza, J M; Lacassin, F; Leport, C; Glauser, M P; Moreillon, P

    1995-01-01

    RP 59500 is a new injectable streptogramin composed of two synergistic components (quinupristin and dalfopristin) which are active against a number of erythromycin-susceptible and -resistant gram-positive bacteria. The following experiments investigate the ability of RP 59500 to prevent experimental endocarditis due to either of two erythromycin-susceptible streptococcal isolates or their constitutively erythromycin-resistant Tn916 delta E transconjugants. RP 59500 had low MICs (0.125 to 0.5 mg/liter) for all four test organisms and was substantially bactericidal in vitro. Rats with catheter-induced aortic vegetations were given single-dose antibiotic prophylaxis 30 to 60 min before bacterial inoculation through a computerized pump system which permitted the simulation of drug kinetics for humans produced by either 7 mg of RP 59500 per kg of body weight or 1 g of vancomycin. Single-dose RP 59500 prophylaxis successfully prevented endocarditis due to both the erythromycin-susceptible parent strains and their erythromycin-resistant derivatives in rats challenged with the minimal inoculum infecting 90% of controls. In addition, RP 59500 also prevented infection in animals challenged with fivefold-larger inocula of the erythromycin-susceptible parent strains. Vancomycin successfully prevented endocarditis due to any of the four test organisms. These results underline the in vivo efficacy of RP 59500 against both erythromycin-susceptible and -resistant streptococci. Such good results against the resistant strains would not be expected with erythromycin or clindamycin, which are the standard macrolidelincosamide-streptogramin antibiotics used for endocarditis prophylaxis in humans. An oral form of RP 59500 which might advantageously replace some of the older prophylactic regimens is currently being developed. PMID:7492079

  13. Uncertainty of permeability and specific storage due to experimental error during data acquisition for pulse-transient technique

    NASA Astrophysics Data System (ADS)

    Song, I.; Rathbun, A. P.; Saffer, D. M.

    2011-12-01

    Transient fluid flow through rock is governed by two hydraulic properties: permeability (k) and the specific storage (Ss), which are often determined by the pulse-transient technique when k is extremely low (e.g. k < 10-19 m2). The basic test system is composed of a pressure-confined rock sample connected to two closed reservoirs at its upstream and downstream ends. A pulse of pressure at the upstream boundary drives transient flow through the sample to the downstream end. The rock properties, k and Ss, can be determined by time-based recording of only one variable, the pressure change in each reservoir. Experimental error during data acquisition propagates through the data reduction process, leading to uncertainty in experimental results. In addition, unlike steady-state systems, the pressure-time curves are influenced by the compressive storage of the reservoirs and both the dimensions and properties of the sample. Thus, uncertainty in k and Ss may arise from errors in measurement of sample dimension, fluid pressure, or reservoir storages. In this study, the uncertainty in sample dimension is considered to be negligible, and reasonable error ranges in pressure and system storage measurements are considered. We first calculated pressure errors (P) induced by the difference between assumed, or experimentally measured values of k and Ss and their true values. Based on this result, the sensitivity coefficient (∂k/∂P and ∂Ss/∂P) is theoretically ~10 in percentage, i.e. 1% error of the pulse on average during a test cycle produces ~10% uncertainty in k and Ss. The sensitivity coefficient may become larger when the ratio of sample storage to upstream reservoir storage is extremely small. We also examined the sensitivity of experimental error in measuring the storage capacity of system reservoirs to uncertainty in resulting values of k and Ss. Because the reservoirs are typically small for tight rock samples and irregular in shape due to the combination of tubing

  14. A search for the Sunyaev-Zel'dovich effect at millimeter wavelengths. [cosmic background photon energy increase due to Compton scattering by high temperature galactic cluster plasma electrons

    NASA Technical Reports Server (NTRS)

    Meyer, S. S.; Jeffries, A. D.; Weiss, R.

    1983-01-01

    It is believed that X-ray emission from clusters of galaxies represents thermal bremsstrahlung from a hot plasma. According to Sunyaev and Zel'dovich (1972), the plasma column density and temperature derived from this model imply a measurable distortion of the cosmic background radiation (CBR) in the cluster direction. This distortion results from the Compton scattering of the CBR photons by the electrons in the plasma, resulting in an average increase of each photon. This process, known as the Sunyaev-Zel'dovich effect, is photon conserving and 'shifts' the CBR spectrum to higher frequencies. The result is a decrease of flux at frequencies below 7.5 per cm (the Rayleigh-Jeans region), and an increase above. The investigation is concerned with measurements of the Sunyaev-Zel'dovich effect at frequencies in the range from 3 to 10 per cm. Attention is given to the employed observing and analysis technique, and an initial null result for the cluster Abell 1795.

  15. Changes of soil pore system due to soil macrofauna: an experimental approach to study the contribution of different taxa

    NASA Astrophysics Data System (ADS)

    Gargiulo, Laura; Buscemi, Gilda; Mele, Giacomo; Terribile, Fabio

    2015-04-01

    Soil fauna contributes to the ecosystem functioning, for example, by means of its direct influence on soil structure which modifies the physical environment of the microbial community. Changes in habitat structure due to soil fauna activities can influence resource availability, species' abundances, and community composition of soil microorganisms. X-ray tomography has been increasingly used to obtain precise and non-destructive analysis mostly of the macroporosity resulting from earthworm activity in repacked soil cores. However also other macrofauna species contribute in different manner and extent to the modification of soil pore system, and then to the soil functioning, by means of their burrows and bioturbation activity. In this work we have developed an experimental approach based on the use of repacked soil mesocosms specifically constructed for the purpose of distinguish separately the contribution to soil structure changes of different organisms naturally present in field or inoculated in laboratory. Six different orders of macrofauna were studied and after four weeks of fauna activity the cores were imaged using a medical X-ray tomograph. Three-dimensional image processing was used in order to obtain 3D reconstructions and preliminary analysis of the identified biopores. In addition to the earthworms (Haplotaxida, genus Lombricus), among the studied taxa, Embioptera showed the most intense burrowing activity, while Coleoptera larvae (sp. Elater sanguineus) and Julida (class Diplopoda) produced the thickest pore network in our mesocosms. The used experimental approach showed a promising potential to provide new useful information about the widely differentiated contribution of many types of macrofauna to the modification of soil pore system.

  16. Acceleration of plasma electrons by intense nonrelativistic ion and electron beams propagating in background plasma due to two-stream instability

    NASA Astrophysics Data System (ADS)

    Kaganovich, Igor D.

    2015-11-01

    In this paper we study the effects of the two-stream instability on the propagation of intense nonrelativistic ion and electron beams in background plasma. Development of the two-stream instability between the beam ions and plasma electrons leads to beam breakup, a slowing down of the beam particles, acceleration of the plasma particles, and transfer of the beam energy to the plasma particles and wave excitations. Making use of the particle-in-cell codes EDIPIC and LSP, and analytic theory we have simulated the effects of the two-stream instability on beam propagation over a wide range of beam and plasma parameters. Because of the two-stream instability the plasma electrons can be accelerated to velocities as high as twice the beam velocity. The resulting return current of the accelerated electrons may completely change the structure of the beam self - magnetic field, thereby changing its effect on the beam from focusing to defocusing. Therefore, previous theories of beam self-electromagnetic fields that did not take into account the effects of the two-stream instability must be significantly modified. This effect can be observed on the National Drift Compression Experiment-II (NDCX-II) facility by measuring the spot size of the extracted beamlet propagating through several meters of plasma. Particle-in-cell, fluid simulations, and analytical theory also reveal the rich complexity of beam- plasma interaction phenomena: intermittency and multiple regimes of the two-stream instability in dc discharges; band structure of the growth rate of the two-stream instability of an electron beam propagating in a bounded plasma and repeated acceleration of electrons in a finite system. In collaboration with E. Tokluoglu, D. Sydorenko, E. A. Startsev, J. Carlsson, and R. C. Davidson. Research supported by the U.S. Department of Energy.

  17. Experimental and numerical evaluation of the force due to the impact of a dam-break wave on a structure

    NASA Astrophysics Data System (ADS)

    Aureli, Francesca; Dazzi, Susanna; Maranzoni, Andrea; Mignosa, Paolo; Vacondio, Renato

    2015-02-01

    Flood events caused by the collapse of dams or river levees can have damaging consequences on buildings and infrastructure located in prone areas. Accordingly, a careful prediction of the hydrodynamic load acting on structures is important for flood hazard assessment and potential damage evaluation. However, this represents a challenging task and requires the use of suitable mathematical models. This paper investigates the capability of three different models, i.e. a 2D depth-averaged model, a 3D Eulerian two-phase model, and a 3D Smoothed Particle Hydrodynamics (SPH) model, to estimate the impact load exerted by a dam-break wave on an obstacle. To this purpose, idealised dam-break experiments were carried out by generating a flip-through impact against a rigid squat structure, and measurements of the impact force were obtained directly by using a load cell. The dynamics of the impact event was analyzed and related to the measured load time history. A repeatability analysis was performed due to the great variability typically shown by impact phenomena, and a confidence range was estimated. The comparison between numerical results and experimental data shows the capability of 3D models to reproduce the key features of the flip-through impact. The 2D modelling based on the shallow water approach is not entirely suitable to accurately reproduce the load hydrograph and predict the load peak values; this difficulty increases with the strength of the wave impact. Nevertheless, the error in the peak load estimation is in the order of 10% only, thus the 2D approach may be considered appropriate for practical applications. Moreover, when the shallow water approximation is expected to work well, 2D results are comparable with the experimental data, as well as with the numerical predictions of far more sophisticated and computationally demanding 3D solvers. All the numerical models overestimate the falling limb of the load hydrograph after the impact. The SPH model ensures

  18. Experimental study of the efficacy of linezolid alone and in combinations against experimental meningitis due to Staphylococcus aureus strains with decreased susceptibility to beta-lactams and glycopeptides.

    PubMed

    Cabellos, Carmen; Garrigós, Carmen; Taberner, Ferran; Force, Enriqueta; Pachón-Ibañez, M Eugenia

    2014-09-01

    To evaluate in vitro and in vivo efficacies of linezolid, vancomycin, and the combination of linezolid and rifampicin against two Staphylococcus aureus strains with reduced susceptibility to beta-lactams and one of them also to glycopeptides. In vitro killing curves and a rabbit model: Meningitis was induced by intracisternal inoculation of 10(8) CFU/ml of each strain. Five hours later (0 h), rabbits were randomly assigned to control or to therapeutic groups. CSF bacterial counts, lactate and protein concentrations, and pharmacokinetic parameters were determined. In vivo: linezolid and its combination with rifampicin reduced bacterial concentrations at 24 h, median cfu/mL 4.85 vs 3.87 (p < 0.05) for linezolid and 5.02 vs 4.21 (p < 0.05) for linezolid + rifampicin, against the glycopeptide intermediate S. aureus (GISA) strain and improved inflammatory parameters. Despite the need for more experimental data, our results suggest that linezolid and its combinations could be considered as a potential alternative in difficult-to-treat CNS infections and especially in those due to GISA strains and deserve more studies. Copyright © 2014 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.

  19. The risk of biomaterial-associated infection after revision surgery due to an experimental primary implant infection.

    PubMed

    Engelsman, Anton F; Saldarriaga-Fernandez, Isabel C; Nejadnik, M Reza; van Dam, Gooitzen M; Francis, Kevin P; Ploeg, Rutger J; Busscher, Henk J; van der Mei, Henny C

    2010-10-01

    The fate of secondary biomaterial implants was determined by bio-optical imaging and plate counting, after antibiotic treatment of biomaterials-associated-infection (BAI) and surgical removal of an experimentally infected, primary implant. All primary implants and tissue samples from control mice showed bioluminescence and were culture-positive. In an antibiotic treated group, no bioluminescence was detected and only 20% of all primary implants and no tissue samples were culture-positive. After revision surgery, bioluminescence was detected in all control mice. All the implants and 80% of all tissue samples were culture-positive. In contrast, in the antibiotic treated group, 17% of all secondary implants and 33% of all tissue samples were culture-positive, despite antibiotic treatment. The study illustrates that due to the BAI of a primary implant, the infection risk of biomaterial implants is higher in revision surgery than in primary surgery, emphasizing the need for full clearance of the infection, as well as from surrounding tissues prior to implantation of a secondary implant.

  20. Routes towards the experimental observation of the large fluctuations due to chaos-assisted tunneling effects with cold atoms

    NASA Astrophysics Data System (ADS)

    Dubertrand, R.; Billy, J.; Guéry-Odelin, D.; Georgeot, B.; Lemarié, G.

    2016-10-01

    In the presence of a complex classical dynamics associated with a mixed phase space, a quantum wave function can tunnel between two stable islands through the chaotic sea, an effect that has no classical counterpart. This phenomenon, referred to as chaos-assisted tunneling, is characterized by large fluctuations of the tunneling rate when a parameter is varied. To date, the full extent of this effect as well as the associated statistical distribution have never been observed in a quantum system. Here, we analyze the possibility of characterizing these effects accurately in a cold-atom experiment. Using realistic values of the parameters of an experimental setup, we examine through analytical estimates and extensive numerical simulations a specific system that can be implemented with cold atoms, the atomic modulated pendulum. We assess the efficiency of three possible routes to observe in detail chaos-assisted tunneling properties. Our main conclusion is that due to the fragility of the symmetry between positive and negative momenta as a function of quasimomentum, it is very challenging to use tunneling between classical islands centered on fixed points with opposite momentum. We show that it is more promising to use islands symmetric in position space, and characterize the regime where it could be done. The proposed experiment could be realized with current state-of-the-art technology.

  1. The protective effect of L-carnitine against hippocampal damage due to experimental formaldehyde intoxication in rats.

    PubMed

    Ozmen, E; Ozsoy, S Y; Donmez, N; Ozsoy, B; Yumuşak, N

    2014-07-01

    We investigated the protective effects of L-carnitine on hippocampus tissue damage in rats during experimental formaldehyde (FA) intoxication. Male Wistar albino rats were assigned into four groups: (1) control (C), (2) formaldehyde (FA), (3) formaldehyde + 0.5 g/kg of L-carnitine (FA + 0.5 LC) (4) formaldehyde + 1 g/kg L-carnitine (FA + 1 LC). At the end of the 14 day trial period, animals were sacrificed by decapitation under anesthesia. The hippocampus tissue samples were extracted to measure MDA, GSH and SOD activity. Neuronal degeneration was assessed based on histopathological (hematoxylin and eosin) and immunohistochemical (anti-ubiquitin) examination. To detect oxidative stress, specimens were reacted with anti-Cu/Zn-SOD antibody. After administering L-carnitine with FA to the animals, the activities of SOD and GSH increased, but the levels of MDA decreased in hippocampus tissue. Neuronal degeneration was observed in the FA group. L-carnitine administration reduced neuronal degeneration and histological structure was similar to controls. After FA application, degenerated hippocampus neurons were stained with anti-ubiquitin and Cu/Zn-SOD antibodies; weakly positive staining was observed in L- carnitine-treated groups. L-carnitine may be useful for preventing oxidative damage in the hippocampus tissue due to formaldehyde intoxication.

  2. Efficacy of Ampicillin plus Ceftriaxone in Treatment of Experimental Endocarditis Due to Enterococcus faecalis Strains Highly Resistant to Aminoglycosides

    PubMed Central

    Gavaldà, Joan; Torres, Carmen; Tenorio, Carmen; López, Pedro; Zaragoza, Myriam; Capdevila, Josep A.; Almirante, Benito; Ruiz, Fernanda; Borrell, Nuria; Gomis, Xavier; Pigrau, Carles; Baquero, Fernando; Pahissa, Albert

    1999-01-01

    The purpose of this work was to evaluate the in vitro possibilities of ampicillin-ceftriaxone combinations for 10 Enterococcus faecalis strains with high-level resistance to aminoglycosides (HLRAg) and to assess the efficacy of ampicillin plus ceftriaxone, both administered with humanlike pharmacokinetics, for the treatment of experimental endocarditis due to HLRAg E. faecalis. A reduction of 1 to 4 dilutions in MICs of ampicillin was obtained when ampicillin was combined with a fixed subinhibitory ceftriaxone concentration of 4 μg/ml. This potentiating effect was also observed by the double disk method with all 10 strains. Time-kill studies performed with 1 and 2 μg of ampicillin alone per ml or in combination with 5, 10, 20, 40, and 60 μg of ceftriaxone per ml showed a ≥2 log10 reduction in CFU per milliliter with respect to ampicillin alone and to the initial inoculum for all 10 E. faecalis strains studied. This effect was obtained for seven strains with the combination of 2 μg of ampicillin per ml plus 10 μg of ceftriaxone per ml and for six strains with 5 μg of ceftriaxone per ml. Animals with catheter-induced endocarditis were infected intravenously with 108 CFU of E. faecalis V48 or 105 CFU of E. faecalis V45 and were treated for 3 days with humanlike pharmacokinetics of 2 g of ampicillin every 4 h, alone or combined with 2 g of ceftriaxone every 12 h. The levels in serum and the pharmacokinetic parameters of the humanlike pharmacokinetics of ampicillin or ceftriaxone in rabbits were similar to those found in humans treated with 2 g of ampicillin or ceftriaxone intravenously. Results of the therapy for experimental endocarditis caused by E. faecalis V48 or V45 showed that the residual bacterial titers in aortic valve vegetations were significantly lower in the animals treated with the combinations of ampicillin plus ceftriaxone than in those treated with ampicillin alone (P < 0.001). The combination of ampicillin and ceftriaxone showed in vitro and

  3. Experimental observation of microwave absorption and electron heating due to the two plasmon decay instability and resonance absorption

    SciTech Connect

    Rasmussen, D.A.

    1981-01-01

    The interaction of intense microwaves with an inhomogeneous plasma is studied in two experimental devices. In the first device an investigation was made of microwave absorption and electron heating due to the parametric decay of microwaves into electron plasma waves (Two Plasmon Decay instability, TPDI), modeling a process which can occur near the quarter critical surface in laser driven pellets. P-polarized microwave (f = 1.2 GHz, P/sub 0/ less than or equal to 12 kW) are applied to an essentially collisionless, inhomogeneous plasma, in an oversized waveguide, in the U.C. Davis Prometheus III device. The initial density scale length near the quarter critical surface is quite long (L/lambda/sub De/ approx. = 3000 or k/sub 0/L approx. = 15). The observed threshold power for the TPDI is quite low (P/sub T/approx. = 0.1 kW or v/sub os//v/sub e/ approx. = 0.1). Near the threshold the decay waves only occur near the quarter critical surface. As the incident power is increased above threshold, the decay waves spread to lower densities, and for P/sub 0/ greater than or equal to lkW, (v/sub os//v/sub e/ greater than or equal to 0.3) suprathermal electron heating is strong for high powers (T/sub H/ less than or equal to 12 T/sub e/ for P/sub 0/ less than or equal to 8 kW or v/sub os//v/sub e/ less than or equal to 0.9).

  4. Light and Nutrient Dependent Responses in Secondary Metabolites of Plantago lanceolata Offspring Are Due to Phenotypic Plasticity in Experimental Grasslands.

    PubMed

    Miehe-Steier, Annegret; Roscher, Christiane; Reichelt, Michael; Gershenzon, Jonathan; Unsicker, Sybille B

    2015-01-01

    A few studies in the past have shown that plant diversity in terms of species richness and functional composition can modify plant defense chemistry. However, it is not yet clear to what extent genetic differentiation of plant chemotypes or phenotypic plasticity in response to diversity-induced variation in growth conditions or a combination of both is responsible for this pattern. We collected seed families of ribwort plantain (Plantago lanceolata) from six-year old experimental grasslands of varying plant diversity (Jena Experiment). The offspring of these seed families was grown under standardized conditions with two levels of light and nutrients. The iridoid glycosides, catalpol and aucubin, and verbascoside, a caffeoyl phenylethanoid glycoside, were measured in roots and shoots. Although offspring of different seed families differed in the tissue concentrations of defensive metabolites, plant diversity in the mothers' environment did not explain the variation in the measured defensive metabolites of P. lanceolata offspring. However secondary metabolite levels in roots and shoots were strongly affected by light and nutrient availability. Highest concentrations of iridoid glycosides and verbascoside were found under high light conditions, and nutrient availability had positive effects on iridoid glycoside concentrations in plants grown under high light conditions. However, verbascoside concentrations decreased under high levels of nutrients irrespective of light. The data from our greenhouse study show that phenotypic plasticity in response to environmental variation rather than genetic differentiation in response to plant community diversity is responsible for variation in secondary metabolite concentrations of P. lanceolata in the six-year old communities of the grassland biodiversity experiment. Due to its large phenotypic plasticity P. lanceolata has the potential for a fast and efficient adjustment to varying environmental conditions in plant communities of

  5. Light and Nutrient Dependent Responses in Secondary Metabolites of Plantago lanceolata Offspring Are Due to Phenotypic Plasticity in Experimental Grasslands

    PubMed Central

    Miehe-Steier, Annegret; Roscher, Christiane; Reichelt, Michael; Gershenzon, Jonathan; Unsicker, Sybille B.

    2015-01-01

    A few studies in the past have shown that plant diversity in terms of species richness and functional composition can modify plant defense chemistry. However, it is not yet clear to what extent genetic differentiation of plant chemotypes or phenotypic plasticity in response to diversity-induced variation in growth conditions or a combination of both is responsible for this pattern. We collected seed families of ribwort plantain (Plantago lanceolata) from six-year old experimental grasslands of varying plant diversity (Jena Experiment). The offspring of these seed families was grown under standardized conditions with two levels of light and nutrients. The iridoid glycosides, catalpol and aucubin, and verbascoside, a caffeoyl phenylethanoid glycoside, were measured in roots and shoots. Although offspring of different seed families differed in the tissue concentrations of defensive metabolites, plant diversity in the mothers' environment did not explain the variation in the measured defensive metabolites of P. lanceolata offspring. However secondary metabolite levels in roots and shoots were strongly affected by light and nutrient availability. Highest concentrations of iridoid glycosides and verbascoside were found under high light conditions, and nutrient availability had positive effects on iridoid glycoside concentrations in plants grown under high light conditions. However, verbascoside concentrations decreased under high levels of nutrients irrespective of light. The data from our greenhouse study show that phenotypic plasticity in response to environmental variation rather than genetic differentiation in response to plant community diversity is responsible for variation in secondary metabolite concentrations of P. lanceolata in the six-year old communities of the grassland biodiversity experiment. Due to its large phenotypic plasticity P. lanceolata has the potential for a fast and efficient adjustment to varying environmental conditions in plant communities of

  6. Treatment of experimental endocarditis due to erythromycin-susceptible or -resistant methicillin-resistant Staphylococcus aureus with RP 59500.

    PubMed

    Entenza, J M; Drugeon, H; Glauser, M P; Moreillon, P

    1995-07-01

    RP 59500 is a new injectable streptogramin composed of two synergistic components (quinupristin and dalfopristin) which are active against erythromycin-susceptible and -resistant gram-positive pathogens. The present experiments compared the therapeutic efficacy of RP 59500 with that of vancomycin against experimental endocarditis due to either of two erythromycin-susceptible or two constitutively erythromycin-resistant isolates of methicillin-resistant Staphylococcus aureus. RP 59500 had low MICs for the four test organisms as well as for 24 additional isolates (the MIC at which 90% of the isolates were inhibited was < 1 mg/liter) which were mostly inducibly (47%) or constitutively (39%) erythromycin resistant. Aortic endocarditis in rats was produced with catheter-induced vegetations. Three-day therapy was initiated 12 h after infection, and the drugs were delivered via a computerized pump, which permitted the mimicking of the drug kinetics produced in human serum by twice-daily intravenous injections of 7 mg of RP 59500 per kg of body weight or 1 g of vancomycin. Both antibiotics reduced vegetation bacterial titers to below detection levels in ca. 70% of animals infected with the erythromycin-susceptible isolates (P < 0.05 compared with titers in controls). Vancomycin was also effective against the constitutively resistant strains, but RP 59500 failed against these isolates. Further experiments proved that RP 59500 failures were related to the very short life span of dalfopristin in serum (< or = 2 h, compared with > or = 6 h for quinupristin), since successful treatment was restored by artificially prolonging the dalfopristin levels for 6 h. Thus, RP 59500 is a promising alternative to vancomycin against methicillin-resistant S. aureus infections, provided that pharmacokinetic parameters are adjusted to afford prolonged levels of both of its constituents in serum. This observation is also relevant to humans, in whom the life span of dalfopristin in serum is also

  7. Quantifying flow retention due to vegetation in an earthen experimental channel using the Aggregated Dead Zone (ADZ) dilution approach

    NASA Astrophysics Data System (ADS)

    Carling, Paul; Kleinhans, Maarten; Leyland, Julian; Besozzi, Louison; Duranton, Pierre; Trieu, Hai; Teske, Roy

    2014-05-01

    Understanding of flow resistance of forested floodplains is essential for floodplain flow routing and floodplain reforestation projects. Although the flow resistance of grass-lined channels is well-known, flow retention due to flow-blocking by trees is poorly understood. Flow behaviour through tree-filled channels or over forested floodplain surfaces has largely been addressed using laboratory studies of artificial surfaces and vegetation. Herein we take advantage of a broad, shallow earthen experimental outdoor channel with headwater and tailwater controls. The channel was disused and left undisturbed for more than 20 years. During this time period, small deciduous trees and a soil cover of grass, herbs and leaf-litter established naturally. We measured flow resistance and fluid retention in fifteen controlled water discharge experiments for the following conditions: (a) natural cover of herbs and trees; (b) trees only and; (c) earthen channel only. In the b-experiments the herbaceous groundcover was first removed carefully and in the c-experiments the trees were first cut flush with the earthen channel floor. Rhodamine-B dye was used to tag the flow and the resultant fluorescence of water samples were systematically assayed through time at two stations along the length of the channel. Dilution-curve data were analysed within the Aggregated Dead Zone (ADZ) framework to yield bulk flow parameters including dispersion, fluid retention and flow resistance parameters after the procedure of Richardson & Carling (2006). The primary response of the bulk flow to vegetation removal was an increase in bulk velocity, with depth and wetted width decreasing imperceptibly at the resolution of measurement. An overall reduction in flow resistance and retention occurred as discharge increased in all experiments and flow retention. Retentiveness was more prominent during low flow and for all three experimental conditions tended to converge on a constant low value for high

  8. Genetic Background Can Result in a Marked or Minimal Effect of Gene Knockout (GPR55 and CB2 Receptor) in Experimental Autoimmune Encephalomyelitis Models of Multiple Sclerosis

    PubMed Central

    Jackson, Samuel J.; Tanner, Carolyn; Ross, Ruth A.; Michael, Gregory J.; Selwood, David L.; Giovannoni, Gavin; Baker, David

    2013-01-01

    Endocannabinoids and some phytocannabinoids bind to CB1 and CB2 cannabinoid receptors, transient receptor potential vanilloid one (TRPV1) receptor and the orphan G protein receptor fifty-five (GPR55). Studies using C57BL/10 and C57BL/6 (Cnr2tm1Zim) CB2 cannabinoid receptor knockout mice have demonstrated an immune-augmenting effect in experimental autoimmune encephalomyelitis (EAE) models of multiple sclerosis. However, other EAE studies in Biozzi ABH mice often failed to show any treatment effect of either CB2 receptor agonism or antagonism on inhibition of T cell autoimmunity. The influence of genetic background on the induction of EAE in endocannabinoid system-related gene knockout mice was examined. It was found that C57BL/6.GPR55 knockout mice developed less severe disease, notably in female mice, following active induction with myelin oligodendrocyte glycoprotein 35-55 peptide. In contrast C57BL/6.CB2 (Cnr2Dgen) receptor knockout mice developed augmented severity of disease consistent with the genetically and pharmacologically-distinct, Cnr2tm1Zim mice. However, when the knockout gene was bred into the ABH mouse background and EAE induced with spinal cord autoantigens the immune-enhancing effect of CB2 receptor deletion was lost. Likewise CB1 receptor and transient receptor potential vanilloid one knockout mice on the ABH background demonstrated no alteration in immune-susceptibility, in terms of disease incidence and severity of EAE, in contrast to that reported in some C57BL/6 mouse studies. Furthermore the immune-modulating influence of GPR55 was marginal on the ABH mouse background. Whilst sedative doses of tetrahydrocannabinol could induce immunosuppression, this was associated with a CB1 receptor rather than a CB2 receptor-mediated effect. These data support the fact that non-psychoactive doses of medicinal cannabis have a marginal influence on the immune response in MS. Importantly, it adds a note of caution for the translational value of some

  9. Genetic background can result in a marked or minimal effect of gene knockout (GPR55 and CB2 receptor) in experimental autoimmune encephalomyelitis models of multiple sclerosis.

    PubMed

    Sisay, Sofia; Pryce, Gareth; Jackson, Samuel J; Tanner, Carolyn; Ross, Ruth A; Michael, Gregory J; Selwood, David L; Giovannoni, Gavin; Baker, David

    2013-01-01

    Endocannabinoids and some phytocannabinoids bind to CB1 and CB2 cannabinoid receptors, transient receptor potential vanilloid one (TRPV1) receptor and the orphan G protein receptor fifty-five (GPR55). Studies using C57BL/10 and C57BL/6 (Cnr2 (tm1Zim)) CB2 cannabinoid receptor knockout mice have demonstrated an immune-augmenting effect in experimental autoimmune encephalomyelitis (EAE) models of multiple sclerosis. However, other EAE studies in Biozzi ABH mice often failed to show any treatment effect of either CB2 receptor agonism or antagonism on inhibition of T cell autoimmunity. The influence of genetic background on the induction of EAE in endocannabinoid system-related gene knockout mice was examined. It was found that C57BL/6.GPR55 knockout mice developed less severe disease, notably in female mice, following active induction with myelin oligodendrocyte glycoprotein 35-55 peptide. In contrast C57BL/6.CB2 (Cnr2 (Dgen)) receptor knockout mice developed augmented severity of disease consistent with the genetically and pharmacologically-distinct, Cnr2 (tm1Zim) mice. However, when the knockout gene was bred into the ABH mouse background and EAE induced with spinal cord autoantigens the immune-enhancing effect of CB2 receptor deletion was lost. Likewise CB1 receptor and transient receptor potential vanilloid one knockout mice on the ABH background demonstrated no alteration in immune-susceptibility, in terms of disease incidence and severity of EAE, in contrast to that reported in some C57BL/6 mouse studies. Furthermore the immune-modulating influence of GPR55 was marginal on the ABH mouse background. Whilst sedative doses of tetrahydrocannabinol could induce immunosuppression, this was associated with a CB1 receptor rather than a CB2 receptor-mediated effect. These data support the fact that non-psychoactive doses of medicinal cannabis have a marginal influence on the immune response in MS. Importantly, it adds a note of caution for the translational value of some

  10. Influence of experimental parameters on the determination of antimony in seawater by atomic absorption spectrometry using a transversely heated graphite furnace with Zeeman-effect background correction.

    PubMed

    Cabon, Jean Yves

    2002-12-01

    Spectroscopic and electrothermal conditions for the determination of antimony in seawater using a transversely heated graphite furnace with Zeeman-effect background correction have been optimized with the use of an a priori calculation of the detection limit. The lowest limit of detection was obtained with a 2 nm spectral curvatures bandwidth and the use of an electrodeless discharge lamp; however, these experimental conditions resulted in strong premature curvature of calibration curves. Pd(NO(3))(2) can be recommended as a chemical modifier because seawater interference effects are minimized and pretreatment curves up to 1500 degrees C can be used permitting the removal of the major part of the saline matrix before atomization. Under optimized spectroscopic and electrothermal conditions the obtained limit of detection of Sb in seawater was about 0.4 microg L(-1).

  11. Cosmic Coincidences: Investigations for Neutron Background Suppression

    PubMed Central

    Heimbach, Craig R.

    2007-01-01

    Two experimental investigations were made in order to reduce background counts in neutron detectors. Each investigation relied upon the fact that neutron background is largely due to cosmic ray interactions with the air and ground. The first attempt was to look at neutron arrival times. Neutron events close in time were taken to have been of a common origin due to cosmic rays. The second investigation was similar, but based on coincident neutron/muon events. The investigations showed only a small effect, not practical for the suppression of neutron background. PMID:27110457

  12. Cosmic Coincidences: Investigations for Neutron Background Suppression.

    PubMed

    Heimbach, Craig R

    2007-01-01

    Two experimental investigations were made in order to reduce background counts in neutron detectors. Each investigation relied upon the fact that neutron background is largely due to cosmic ray interactions with the air and ground. The first attempt was to look at neutron arrival times. Neutron events close in time were taken to have been of a common origin due to cosmic rays. The second investigation was similar, but based on coincident neutron/muon events. The investigations showed only a small effect, not practical for the suppression of neutron background.

  13. [A comparative analysis of healing mandibular defects due to exposure to different plastic materials (experimental morphological study)].

    PubMed

    Fedorovskaya, L N; Grigor'ian, A S; Kulakov, A A; Khamraev, T K

    2001-01-01

    Autogenous bone grafts are the most effective factor able to activate osteogenesis in bone defects, as shown by our experiments. Experimental biomaterials such as Bio-Oss and KP-3 have a high osteogenesis potential, too. However the callus initiated in jaw defects by those biomaterials underwent partial reduction during secondary rebuilding, thus becoming a less authentic bone formation.

  14. Experimental demonstration and modeling of the internal light scattering profile within solar cells due to random dielectric scatterers

    NASA Astrophysics Data System (ADS)

    Murray, Joseph; Munday, Jeremy N.

    2016-01-01

    Many photovoltaic technologies are shifting toward thin-film devices to simultaneously reduce costs and improve carrier collection efficiencies; however, the need for nearly complete light absorption within the semiconductor to achieve large short-circuit currents constrains this thickness reduction. Light trapping strategies can be employed to increase absorption in thinner devices. Random scattering coatings offer a simple, cost-effective way to increase solar cell absorption without the drawback of increased surface recombination or reduced bandwidth that occurs when using surface texturing or gratings. However, coatings that show excellent performance as scatterers in free space generally do not enhance device absorption as much as an ideal Lambertian scatterer. Here, we present an experimental technique and theoretical model that accurately describes the absorption improvement that is achievable with coatings based on random ensembles of dielectric scatterers. We find that the ideal Lambertian model substantially overestimates the experimental scattering results, but significant path length enhancements are still achievable. The experimental techniques presented here should enable the testing of various optical models that attempt to surpass the ray optics light trapping limit, which have in many cases been hindered by the experimental difficulty of coupling the incident light into the optical modes of the absorber.

  15. Uncertainties in sediment erodibility estimates due to a lack of standards for experimental protocols and data interpretation.

    PubMed

    Sanford, Lawrence P

    2006-01-01

    Quantitative prediction of the erodibility of muds and mud-sand mixtures is, at present, seldom possible without resorting to direct measurements, preferably in situ. A variety of devices and protocols have been developed for erosion testing, but a considerable degree of uncertainty remains with regard to the accuracy and comparability of the resulting data. This paper argues that differences in experimental protocols and data analysis procedures are a major contributing factor to uncertainty in estimates of sediment erodibility. In particular, the likelihood of a time-dependent erosion rate response under typical erosion testing conditions means that the time history of applied forcing and the chosen protocols for analyzing and interpreting data directly affect derived erosion parameters. Several straightforward ways to address this problem are suggested, including standardization of experimental design and data analysis protocols, explicit recognition and adoption of appropriate erosion model(s), and allowing for potential time/depth changes in erodibility. Experimentalists should also archive and share erosion-test time series, not just derived parameters, so that data sets may be reanalyzed within a different framework if necessary. An example is presented from an intercomparison experiment between the Virginia Institute of Marine Sciences Sea Carousel and the University of Maryland Center for Environmental Science Microcosm System, carried out in the upper Chesapeake Bay (Maryland, USA) in May 2002. Derived parameters appear to be incompatible when the data are analyzed using different procedures, but real similarities and differences are readily apparent when the data are analyzed using the same procedures.

  16. Identification of source velocities on 3D structures in non-anechoic environments: Theoretical background and experimental validation of the inverse patch transfer functions method

    NASA Astrophysics Data System (ADS)

    Aucejo, M.; Totaro, N.; Guyader, J.-L.

    2010-08-01

    In noise control, identification of the source velocity field remains a major problem open to investigation. Consequently, methods such as nearfield acoustical holography (NAH), principal source projection, the inverse frequency response function and hybrid NAH have been developed. However, these methods require free field conditions that are often difficult to achieve in practice. This article presents an alternative method known as inverse patch transfer functions, designed to identify source velocities and developed in the framework of the European SILENCE project. This method is based on the definition of a virtual cavity, the double measurement of the pressure and particle velocity fields on the aperture surfaces of this volume, divided into elementary areas called patches and the inversion of impedances matrices, numerically computed from a modal basis obtained by FEM. Theoretically, the method is applicable to sources with complex 3D geometries and measurements can be carried out in a non-anechoic environment even in the presence of other stationary sources outside the virtual cavity. In the present paper, the theoretical background of the iPTF method is described and the results (numerical and experimental) for a source with simple geometry (two baffled pistons driven in antiphase) are presented and discussed.

  17. AN EXPERIMENTAL PROPOSAL TO STUDY HEAVY-ION COOLING IN THE AGS DUE TO BEAM GAS OR THE INTRABEAM SCATTERING.

    SciTech Connect

    TRBOJEVIC, D.; AHERNS, L.; ROSER, T.; MACKAY, W.; BRENNAN, J.; BLASKIEWICZ,M.; PARZEN, G.; BEEBE-WANG, J.

    2006-06-23

    Low emittance of not-fully-stripped gold (Z=79) Au{sup +77} Helium-like ion beams from the AGS (Alternating Gradient Synchrotron) injector to the Relativistic Heavy Ion Collider (RHIC) could be attributed to the cooling phenomenon due to inelastic intrabeam scattering [1,2] or due to electron de-excitations from collisions with the residual gas [3]. The low emittance gold beams have always been observed at injection in the Relativistic Heavy Ion Collider (RHIC). There have been previous attempts to attribute the low emittance to a cooling due to the exchange of energy between ions during the inelastic intrabeam scattering. The Fano-Lichten theory [4] of electron promotion might be applied during inelastic collisions between helium like gold ions in the AGS. The two K-shell electrons in gold Au{sup +77} could get promoted if the ions reach the critical distance of the closest approach during intra-beam scattering or collisions with the residual gas. During collisions if the ion energy is large enough, a quasi-molecule could be formed, and electron excitation could occur. During de-excitations of electrons, photons are emitted and a loss of total bunch energy could occur. This would lead to smaller beam size. We propose to inject gold ions with two missing electrons into RHIC, at injection energy, and study the beam behavior with bunched and de-bunched beam, varying the RF voltage and the beam intensity. If the ''cooling'' is observed additional X-ray detectors could be installed to observe emitted photons.

  18. Effects of nutritional supplementation with l-arginine on repair of injuries due to muscle strain: experimental study on rats☆

    PubMed Central

    Couto, Lauren Izabel Medeiros; Wuicik, William Luiz; Kuhn, Ivan; Capriotti, Juan Rodolfo Vilela; Repka, João Carlos

    2015-01-01

    Objective To evaluate the influence of oral supplementation with arginine on regeneration of injuries due to straining of the anterior tibial muscle of rats. Methods Twenty-four Wistar rats of weight 492.5 ± 50.45 g were used. Injuries were induced through straining the anterior tibial muscles. The rats were separated into three groups of eight rats each. In the untreated group (UTG), after induction of injuries, the rats were observed for 24 h. In the simulation group (SG) and the arginine group (AG) respectively, the rats received isotonic saline solution and arginine solution via direct gavage, over a seven-day period. At the end of the period, blood samples were collected for serum evaluations of creatine kinase (CK), lactic dehydrogenase (LDH), aspartate aminotransferase (AST) and C-reactive protein (CRP). The right and left anterior tibial muscles were resected for histopathological evaluations on the muscle injuries, investigating edema, hemorrhage and disorganization or morphometric alteration of the muscle fibers. The tissue repair was investigated in terms of proliferation of adipose tissue, angiogenesis and collagen fibers. The ANOVA and Student's t methods were used and p ≤ 0.05 was taken to be statistically significant. Results In the serum evaluations, the AG showed lower CK assay values and higher AST values. In the histopathological evaluation, the UTG presented edema and hemorrhage compatible with injuries due to strain; the SG presented edema and hemorrhage with proliferation of adipose tissue and collagen fibers; and the AG presented not only the findings of the SG but also, especially, intense angiogenesis. Conclusion Oral supplementation with arginine did not cause any significant metabolic alterations that would contraindicate its use and it induced angiogenesis during the repair of muscles injured due to strain. PMID:26401505

  19. Dose perturbations due to contrast medium and air in MammoSite registered treatment: An experimental and Monte Carlo study

    SciTech Connect

    Cheng, C.-W.; Mitra, R.; Allen Li, X.; Das, Indra J.

    2005-07-15

    In the management of early breast cancer, a partial breast irradiation technique called MammoSite registered (Proxima Therapeutic Inc., Alpharetta, GA) has been advocated in recent years. In MammoSite, a balloon implanted at the surgical cavity during tumor excision is filled with a radio-opaque solution, and radiation is delivered via a high dose rate brachytherapy source situated at the center of the balloon. Frequently air may be introduced during placement of the balloon and/or injection of the contrast solution into the balloon. The purpose of this work is to quantify as well as to understand dose perturbations due to the presence of a high-Z contrast medium and/or an air bubble with measurements and Monte Carlo calculations. In addition, the measured dose distribution is compared with that obtained from a commercial treatment planning system (Nucletron PLATO system). For a balloon diameter of 42 mm, the dose variation as a function of distance from the balloon surface is measured for various concentrations of a radio-opaque solution (in the range 5%-25% by volume) with a small volume parallel plate ion chamber and a micro-diode detector placed perpendicular to the balloon axis. Monte Carlo simulations are performed to provide a basic understanding of the interaction mechanism and the magnitude of dose perturbation at the interface near balloon surface. Our results show that the radio-opaque concentration produces dose perturbation up to 6%. The dose perturbation occurs mostly within the distances <1 mm from the balloon surface. The Plato system that does not include heterogeneity correction may be sufficient for dose planning at distances {>=}10 mm from the balloon surface for the iodine concentrations used in the MammoSite procedures. The dose enhancement effect near the balloon surface (<1 mm) due to the higher iodine concentration is not correctly predicted by the Plato system. The dose near the balloon surface may be increased by 0.5% per cm{sup 3} of air

  20. A comparison of experimental and calculated thin-shell leading-edge buckling due to thermal stresses

    NASA Technical Reports Server (NTRS)

    Jenkins, Jerald M.

    1988-01-01

    High-temperature thin-shell leading-edge buckling test data are analyzed using NASA structural analysis (NASTRAN) as a finite element tool for predicting thermal buckling characteristics. Buckling points are predicted for several combinations of edge boundary conditions. The problem of relating the appropriate plate area to the edge stress distribution and the stress gradient is addressed in terms of analysis assumptions. Local plasticity was found to occur on the specimen analyzed, and this tended to simplify the basic problem since it effectively equalized the stress gradient from loaded edge to loaded edge. The initial loading was found to be difficult to select for the buckling analysis because of the transient nature of thermal stress. Multiple initial model loadings are likely required for complicated thermal stress time histories before a pertinent finite element buckling analysis can be achieved. The basic mode shapes determined from experimentation were correctly identified from computation.

  1. VERIFICATION OF NUMERICAL MODEL FOR URBAN INUNDATION DUE TO TORRENTIAL RAINFALL USING PHYSICAL EXPERIMENTAL FLUME WITH A SEWER PIPE

    NASA Astrophysics Data System (ADS)

    Kawaike, Kenji; Shimizu, Atsushi; Baba, Yasuyuki; Nakagawa, Hajime; Takeda, Makoto

    In this paper, in order to verify the stormwater exchange model between ground surface and sewerage system in integrated urban inundation model, we conducted experiments of urban inundation using a flat basin with a sewer pipe and rainfall supplier, and those results are compared with numerical simulation results. From the comparison between them, it is obvious that stormwater drainage and overflow discharge in urban area can be estimated exactly by using step-down formula and overflow formula in steady flow cases. In unsteady flow cases, however, calculated inundation water depth on the ground surface responses to piezometric head of the sewer pipe too quickly than experimental results, which requires much smaller values of the coefficients in those formula.

  2. Experimental verification of gain drop due to general ion recombination for a carbon-ion pencil beam

    SciTech Connect

    Tansho, Ryohei Furukawa, Takuji; Hara, Yousuke; Mizushima, Kota; Saotome, Naoya; Saraya, Yuichi; Shirai, Toshiyuki; Noda, Koji

    2016-02-15

    Purpose: Accurate dose measurement in radiotherapy is critically dependent on correction for gain drop, which is the difference of the measured current from the ideal saturation current due to general ion recombination. Although a correction method based on the Boag theory has been employed, the theory assumes that ionized charge density in an ionization chamber (IC) is spatially uniform throughout the irradiation volume. For particle pencil beam scanning, however, the charge density is not uniform, because the fluence distribution of a pencil beam is not uniform. The aim of this study was to verify the effect of the nonuniformity of ionized charge density on the gain drop due to general ion recombination. Methods: The authors measured the saturation curve, namely, the applied voltage versus measured current, using a large plane-parallel IC and 24-channel parallel-plate IC with concentric electrodes. To verify the effect of the nonuniform ionized charge density on the measured saturation curve, the authors calculated the saturation curve using a method which takes into account the nonuniform ionized charge density and compared it with the measured saturation curves. Results: Measurement values of the different saturation curves in the different channels of the concentric electrodes differed and were consistent with the calculated values. The saturation curves measured by the large plane-parallel IC were also consistent with the calculation results, including the estimation error of beam size and of setup misalignment. Although the impact of the nonuniform ionized charge density on the gain drop was clinically negligible with the conventional beam intensity, it was expected that the impact would increase with higher ionized charge density. Conclusions: For pencil beam scanning, the assumption of the conventional Boag theory is not valid. Furthermore, the nonuniform ionized charge density affects the prediction accuracy of gain drop when the ionized charge density is

  3. Experimental verification of gain drop due to general ion recombination for a carbon-ion pencil beam.

    PubMed

    Tansho, Ryohei; Furukawa, Takuji; Hara, Yousuke; Mizushima, Kota; Saotome, Naoya; Saraya, Yuichi; Shirai, Toshiyuki; Noda, Koji

    2016-02-01

    Accurate dose measurement in radiotherapy is critically dependent on correction for gain drop, which is the difference of the measured current from the ideal saturation current due to general ion recombination. Although a correction method based on the Boag theory has been employed, the theory assumes that ionized charge density in an ionization chamber (IC) is spatially uniform throughout the irradiation volume. For particle pencil beam scanning, however, the charge density is not uniform, because the fluence distribution of a pencil beam is not uniform. The aim of this study was to verify the effect of the nonuniformity of ionized charge density on the gain drop due to general ion recombination. The authors measured the saturation curve, namely, the applied voltage versus measured current, using a large plane-parallel IC and 24-channel parallel-plate IC with concentric electrodes. To verify the effect of the nonuniform ionized charge density on the measured saturation curve, the authors calculated the saturation curve using a method which takes into account the nonuniform ionized charge density and compared it with the measured saturation curves. Measurement values of the different saturation curves in the different channels of the concentric electrodes differed and were consistent with the calculated values. The saturation curves measured by the large plane-parallel IC were also consistent with the calculation results, including the estimation error of beam size and of setup misalignment. Although the impact of the nonuniform ionized charge density on the gain drop was clinically negligible with the conventional beam intensity, it was expected that the impact would increase with higher ionized charge density. For pencil beam scanning, the assumption of the conventional Boag theory is not valid. Furthermore, the nonuniform ionized charge density affects the prediction accuracy of gain drop when the ionized charge density is increased by a higher dose rate and

  4. Experimental approaches to the difference in the Casimir force due to modifications in the optical properties of the boundary surface

    SciTech Connect

    Castillo-Garza, R.; Chang, C.-C.; Jimenez, D.; Mohideen, U.; Klimchitskaya, G. L.; Mostepanenko, V. M.

    2007-06-15

    We propose two experiments on the measurement of the Casimir force acting between a gold coated sphere and semiconductor plates with markedly different charge carrier densities. In the first of these experiments a patterned Si plate is used which consists of two sections of different dopant densities and oscillates in the horizontal direction below a sphere. The measurement scheme in this experiment is differential, i.e., it allows the direct high-precision measurement of the difference of the Casimir forces between the sphere and sections of the patterned plate or the difference of the equivalent pressures between Au and patterned parallel plates with static and dynamic techniques, respectively. The second experiment proposes to measure the Casimir force between the same sphere and a VO{sub 2} film which undergoes the insulator-metal phase transition with the increase of temperature. We report the present status of the interferometer based variable temperature apparatus developed to perform both experiments and present the first results on the calibration and sensitivity. The magnitudes of the Casimir forces and pressures in the experimental configurations are calculated using different theoretical approaches to the description of optical and conductivity properties of semiconductors at low frequencies proposed in the literature. It is shown that the suggested experiments will aid in the resolution of theoretical problems arising in the application of the Lifshitz theory at nonzero temperature to real materials. They will also open new opportunities in nanotechnology.

  5. In vivo magnetic resonance imaging investigating the development of experimental brain metastases due to triple negative breast cancer.

    PubMed

    Hamilton, Amanda M; Foster, Paula J

    2017-02-01

    Triple negative breast cancer (TNBC), when associated with poor outcome, is aggressive in nature with a high incidence of brain metastasis and the shortest median overall patient survival after brain metastasis development compared to all other breast cancer subtypes. As therapies that control primary cancer and extracranial metastatic sites improve, the incidence of brain metastases is increasing and the management of patients with breast cancer brain metastases continues to be a significant clinical challenge. Mouse models have been developed to permit in depth evaluation of breast cancer metastasis to the brain. In this study, we compare the efficiency and metastatic potential of two experimental mouse models of TNBC. Longitudinal MRI analysis and end point histology were used to quantify initial cell arrest as well as the number and volume of metastases that developed in mouse brain over time. We showed significant differences in MRI appearance, tumor progression and model efficiency between the syngeneic 4T1-BR5 model and the xenogeneic 231-BR model. Since TNBC does not respond to many standard breast cancer treatments and TNBC brain metastases lack effective targeted therapies, these preclinical TNBC models represent invaluable tools for the assessment of novel systemic therapeutic approaches. Further pursuits of therapeutics designed to bypass the blood tumor barrier and permit access to the brain parenchyma and metastatic cells within the brain will be paramount in the fight to control and treat lethal metastatic cancer.

  6. Background Underground at WIPP

    NASA Astrophysics Data System (ADS)

    Esch, Ernst-Ingo; Hime, A.; Bowles, T. J.

    2001-04-01

    Recent interest to establish a dedicated underground laboratory in the United States prompted an experimental program at to quantify the enviromental backgrounds underground at the Waste Isolation Pilot Plant (WIPP) in Carlsbad, New Mexico. An outline of this program is provided along with recent experimental data on the cosmic ray muon flux at the 650 meter level of WIPP. The implications of the cosmic ray muon and fast neutron background at WIPP will be discussed in the context of new generation, low background experiments envisioned in the future.

  7. Alteration of Fractured Rocks Due to Coupled Chemical and Mechanical Processes: High-Resolution Simulations and Experimental Observations

    NASA Astrophysics Data System (ADS)

    Ameli, Pasha

    Engineering activities such as enhanced geothermal energy production and improved oil recovery techniques are heavily dependent on the permeability of the subsurface, while others such as CO2 sequestration and nuclear waste disposal rely on the efficiency of rock formations as transport barriers. In either case fractures provide the main pathways for fluid flow and transport, especially in rocks with lower matrix porosity. Laboratory experiments aimed at quantifying the chemo-mechanical responses of fractures have shown a range of results, some of which contradict simple conceptual models. For example, under conditions favoring mineral dissolution, where one would expect an overall increase in permeability, experiments show that permeability increases under some conditions and decreases under others. Recent experiments have attempted to link these core-scale observations to the relevant small-scale processes occurring within fractures. Results suggest that the loss of mechanical strength in asperities due to chemical alteration may cause non-uniform deformation and alteration of fracture apertures. However, due to the lack of direct micro-scale measurements of the coupled chemical and mechanical processes that lead to alteration of contacting fracture surfaces, our ability to predict the long-term evolution of fractures is still limited. To explore the processes that control permeability evolution, I developed a computational model that uses micro-scale surface roughness and explicitly couples dissolution and elastic deformation to calculate local alterations in fracture aperture under chemical and mechanical stresses. A depth-averaged algorithm of fracture flow is used to model reactive transport and chemical alteration of the fracture surfaces. Then, I deform the resulting altered fracture-surfaces using an algorithm that calculates the elastic deformation. The results of the model are compared with flow-through experiments conducted on fractured limestone. The

  8. Full-scale experimental and numerical study about structural behaviour of a thin-walled cold-formed steel building affected by ground settlements due to land subsidence

    NASA Astrophysics Data System (ADS)

    Ortiz, J. A.; Hernández, L. A.; Hernández, M.; Pacheco, J.; Zermeño, M. E.; Salinas, R.

    2015-11-01

    Land subsidence due to ground water withdrawal is a problem in many places around the world (Poland, 1984). This causes differential ground settlements that affect masonry structures, because these structural materials do not exhibit an adequate performance beyond a certain level of angular distortion. This work presents the experimental and numerical results about a study regarding the performance of a full-scale thin-walled cold-formed steel building affected by ground differential settlements due to land subsidence. The experimental stage consisted in the construction of a test-building to be subjected to differential settlements in laboratory. The numerical stage consisted in performing a numerical non-linear static pull-down analysis simulating the differential ground settlements of the test-building. The results show that the structural performance of the tested building was very suitable in terms of ductility.

  9. Enhancement of photodynamic therapy due to hyperbaric hyperoxia: an experimental study of Walker 256 tumors in rats

    NASA Astrophysics Data System (ADS)

    Nicola, Jorge H.; Colussi, Valdir C.; Nicola, Ester M. D.; Metze, Konradin

    1997-05-01

    Photodynamic therapy (PDT), which is now an approved treatment for many types of cancers, is based on the simultaneous involvement of three factors, namely: tumor tissue retention of a specific photosensitizer; local illumination of the lesion with a visible light source and the occurrence of oxygen in the triplet state. Theoretically, a change in any one of these factors may be compensated by a change in the other two factors, leading to the same therapeutic result. In practice, this is not true, since we are dealing with living tissue, but we may expect to find an ideal combination of these three factors which may give the best clinical results. In this work we present experimental results of PDT under Hyperbaric hyperoxia (HBO) in tumor masses of the dorsal subcutaneous tissue of rats. These tumors were created by previous inoculation of 'Walker 256' neoplastic cells Hematoporphyrin Ester (HpE) was administered as the photosensitizer. The rats were pressurized at up to 3 atm with a 100 percent continuous oxygen ventilation environment in a specially designed hyperbaric chamber. The skin area above the tumor was photosensitized for 45 minutes with a 7 mw HeNe laser. Twenty four hours later, the tumor was removed for study. In all the animals treated with PDT/HBO histology revealed a very important reduction in the number of tumor cells as compared with the PDT controls in normal atmospheric condition, showing numerous apoptotic as well as necrotic cells at the border of the radiated area. The observed enhancement in the PDT for this situation is, of course, related to the extra oxygen in the circulatory system.

  10. An experimental measurement of metal multilayer X-ray reflectivity degradation due to intense X-ray flux

    NASA Astrophysics Data System (ADS)

    Hockaday, Mary Yvonne Pottenger

    1987-06-01

    The degradation of the X-ray reflection characteristics of metal multilayer Bragg diffractors due to intense X-ray flux was investigated. Molybdenum-carbon, paladium-carbon, and tungsten-carbon metal multilayers were used. Data for two separate shots were analyzed. For a pure neon gas shot at 420 TW, the reflectivity of the multilayer at 15 cm decayed rapidly with respect to the still-rising signal of the multilayer at 150 cm. The onset time of the decay corresponded to an integrated dose of 5.27 J/sq cm. For a neon implosion onto a vanadium-doped polyacrylic acid foam target shot, detailed modeling was attempted. The spectral flux was determined with data from 5 XRD channels and deconvolved using the code SHAZAM. The observed decay in reflectivity was assumed to correspond to the melting of the first tungsten layer. A conduction factor of 8.9 was required to manipulate the heat loading of the first tungsten layer such that the time of melting corresponded to the observed decay. The power at destruction was 141 MW/sq cm and the integrated energy at destruction was 2.0 J/sq cm.

  11. Efficacy of Ciprofloxacin-Releasing Bioabsorbable Osteoconductive Bone Defect Filler for Treatment of Experimental Osteomyelitis Due to Staphylococcus aureus

    PubMed Central

    Koort, Jyri K.; Mäkinen, Tatu J.; Suokas, Esa; Veiranto, Minna; Jalava, Jari; Knuuti, Juhani; Törmälä, Pertti; Aro, Hannu T.

    2005-01-01

    The concept of local antibiotic delivery via biodegradable bone defect fillers with multifunctional properties for the treatment of bone infections is highly appealing. Fillers can be used to obliterate surgical dead space and to provide targeted local bactericidal concentrations in tissue for extended periods. Eventually, the osteoconductive component of the filler could guide the healing of the bone defect. The present experimental study was carried out to test this concept in a localized Staphylococcus aureus osteomyelitis model in the rabbit (n = 31). A metaphyseal defect of the tibia was filled with a block of bone cement, followed by insertion of a bacterial inoculum. After removal of the bone cement and surgical debridement at 2 weeks, the defect was filled with a ciprofloxacin-containing (7.6% ± 0.1%, by weight) composite (treated-infection group) or with a composite without antibiotic (sham-treated group). Both a positive control group (untreated-infection group) and a negative control group were also produced. The treatment response, monitored by positron emission tomography (PET) with fluorine-18-labeled fluorodeoxyglucose ([18F]FDG) at 3 and 6 weeks, showed rapidly decreasing amounts of [18F]FDG uptake in the treated-infection group (P = 0.001 compared with the results for the untreated-infection group at 6 weeks). The bacteriological analysis confirmed the eradication of the bone pathogen in the treated-infection group. However, three animals had culture-positive soft tissue infections. All animals in the sham-treated and untreated-infection groups had culture-positive bone infections with typical radiographic changes of osteomyelitis. Histomorphometry, peripheral quantitative computed tomography, and backscattered electron imaging of scanning electron microscopy images verified the osteoconductive properties of the bioactive glass microspheres within the composite. The median bone ciprofloxacin concentrations were 1.2 and 2.1 μg/g at two anatomic

  12. Efficacy of ciprofloxacin-releasing bioabsorbable osteoconductive bone defect filler for treatment of experimental osteomyelitis due to Staphylococcus aureus.

    PubMed

    Koort, Jyri K; Mäkinen, Tatu J; Suokas, Esa; Veiranto, Minna; Jalava, Jari; Knuuti, Juhani; Törmälä, Pertti; Aro, Hannu T

    2005-04-01

    The concept of local antibiotic delivery via biodegradable bone defect fillers with multifunctional properties for the treatment of bone infections is highly appealing. Fillers can be used to obliterate surgical dead space and to provide targeted local bactericidal concentrations in tissue for extended periods. Eventually, the osteoconductive component of the filler could guide the healing of the bone defect. The present experimental study was carried out to test this concept in a localized Staphylococcus aureus osteomyelitis model in the rabbit (n = 31). A metaphyseal defect of the tibia was filled with a block of bone cement, followed by insertion of a bacterial inoculum. After removal of the bone cement and surgical debridement at 2 weeks, the defect was filled with a ciprofloxacin-containing (7.6% +/- 0.1%, by weight) composite (treated-infection group) or with a composite without antibiotic (sham-treated group). Both a positive control group (untreated-infection group) and a negative control group were also produced. The treatment response, monitored by positron emission tomography (PET) with fluorine-18-labeled fluorodeoxyglucose ([18F]FDG) at 3 and 6 weeks, showed rapidly decreasing amounts of [18F]FDG uptake in the treated-infection group (P = 0.001 compared with the results for the untreated-infection group at 6 weeks). The bacteriological analysis confirmed the eradication of the bone pathogen in the treated-infection group. However, three animals had culture-positive soft tissue infections. All animals in the sham-treated and untreated-infection groups had culture-positive bone infections with typical radiographic changes of osteomyelitis. Histomorphometry, peripheral quantitative computed tomography, and backscattered electron imaging of scanning electron microscopy images verified the osteoconductive properties of the bioactive glass microspheres within the composite. The median bone ciprofloxacin concentrations were 1.2 and 2.1 microg/g at two

  13. An experimental measurement of metal multilayer x-ray reflectivity degradation due to intense x-ray flux

    SciTech Connect

    Hockaday, M.Y.P.

    1987-06-01

    The degradation of the x-ray reflection characteristics of metal multilayer Bragg diffractors due to intense x-ray flux was investigated. The Z-pinch plasma produced by PROTO II of Sandia National Laboratories, Albuquerque, New Mexico, was used as the source. The plasma generated total x-ray yields of as much as 40 kJ with up to 15 kJ in the neon hydrogen- and helium-like resonance lines in nominal 20-ns pulses. Molybdenum-carbon, palladium-carbon, and tungsten-carbon metal multilayers were placed at 15 and 150 cm from the plasma center. The multilayers were at nominal angles of 5/sup 0/ and 10/sup 0/ to diffract the neon resonance lines. The time-integrated x-ray reflection of the metal multilayers was monitored by x-ray film. A fluorescer-fiber optic-visible streak camera detector system was then used to monitor the time-resolved x-ray reflection characteristics of 135 A- 2d tungsten-carbon multilayers. A large specular component in the reflectivity prevented determination of the rocking curve of the multilayer. For a neon implosion onto a vanadium-doped polyacrylic acid foam target shot, detailed modeling was attempted. The spectral flux was determined with data from 5 XRD channels and deconvolved using the code SHAZAM. The observed decay in reflectivity was assumed to correspond to the melting of the first tungsten layer. A ''conduction factor'' of 82 was required to manipulate the heat loading of the first tungsten layer such that the time of melting corresponded to the observed decay. The power at destruction was 141 MW/cm/sup 2/ and the integrated energy at destruction was 2.0 J/cm/sup 2/. 82 refs., 66 figs., 10 tabs.

  14. A Experimental Measurement of Metal Multilayer X-Ray Reflectivity Degradation due to Intense X-Ray Flux.

    NASA Astrophysics Data System (ADS)

    Hockaday, Mary Yvonne Pottenger

    The degradation of the x-ray reflection characteristics of metal multilayer Bragg diffractors due to intense x -ray flux was investigated. The Z-pinch plasma produced by PROTO II of Sandia National Laboratories, Albuquerque, New Mexico, was used as the source. The plasma generated total x-ray yields of as much as 40 kJ with up to 15 kJ in the neon hydrogen- and helium-like resonance lines in nominal 20-ns pulses. Molybdenum-carbon, paladium-carbon, and tungsten -carbon metal multilayers were placed at 15 and 150 cm from the plasma center. The multilayers were at nominal angles of 5(DEGREES) and 10(DEGREES) to diffract the neon resonance lines. The time-integrated x-ray reflection of the metal multilayers was monitored by x-ray film. A fluorescer -fiber optic-visible streak camera detector system was then used to monitor the time-resolved x-ray reflection characteristics of 135 (ANGSTROM)- 2d tungsten-carbon multilayers. A large specular component in the reflectivity prevented determination of the rocking curve of the multilayer. Data for two separate shots were analyzed. For a pure neon gas shot at a power level of 420 TW, the reflectivity of the multilayer at 15 cm decayed rapidly with respect to the still-rising signal of the multilayer at 150 cm. The onset time of the decay corresponded to an integrated dose of 5.27 J/cm('2). For a neon implosion onto a vanadium-doped polyacrylic acid foam target shot, detailed modeling was attempted. The spectral flux was determined with data from 5 XRD channels and deconvolved using the code SHAZAM. The observed decay in reflectivity was assumed to correspond to the melting of the first tungsten layer. A "conduction factor" of 82 was required to manipulate the heat loading of the first tungsten layer such that the time of melting corresponded to the observed decay. The power at destruction was 141 MW/cm('2) and the integrated energy at destruction was 2.0 J/cm('2).

  15. Increased susceptibility of transgenic mice expressing human PrP to experimental sheep bovine spongiform encephalopathy is not due to increased agent titre in sheep brain tissue

    PubMed Central

    Plinston, Chris; Hart, Patricia; Hunter, Nora; Manson, Jean C.

    2014-01-01

    Bovine spongiform encephalopathy (BSE) in cattle and variant Creutzfeldt–Jakob disease in humans have previously been shown to be caused by the same strain of transmissible spongiform encephalopathy agent. It is hypothesized that the agent spread to humans following consumption of food products prepared from infected cattle. Despite evidence supporting zoonotic transmission, mouse models expressing human prion protein (HuTg) have consistently shown poor transmission rates when inoculated with cattle BSE. Higher rates of transmission have however been observed when these mice are exposed to BSE that has been experimentally transmitted through sheep or goats, indicating that humans may potentially be more susceptible to BSE from small ruminants. Here we demonstrate that increased transmissibility of small ruminant BSE to HuTg mice was not due to replication of higher levels of infectivity in sheep brain tissue, and is instead due to other specific changes in the infectious agent. PMID:24828334

  16. Increased susceptibility of transgenic mice expressing human PrP to experimental sheep bovine spongiform encephalopathy is not due to increased agent titre in sheep brain tissue.

    PubMed

    Plinston, Chris; Hart, Patricia; Hunter, Nora; Manson, Jean C; Barron, Rona M

    2014-08-01

    Bovine spongiform encephalopathy (BSE) in cattle and variant Creutzfeldt-Jakob disease in humans have previously been shown to be caused by the same strain of transmissible spongiform encephalopathy agent. It is hypothesized that the agent spread to humans following consumption of food products prepared from infected cattle. Despite evidence supporting zoonotic transmission, mouse models expressing human prion protein (HuTg) have consistently shown poor transmission rates when inoculated with cattle BSE. Higher rates of transmission have however been observed when these mice are exposed to BSE that has been experimentally transmitted through sheep or goats, indicating that humans may potentially be more susceptible to BSE from small ruminants. Here we demonstrate that increased transmissibility of small ruminant BSE to HuTg mice was not due to replication of higher levels of infectivity in sheep brain tissue, and is instead due to other specific changes in the infectious agent. © 2014 The Authors.

  17. DETECTORS AND EXPERIMENTAL METHODS: Study on spatial resolution of micromegas as a neutron detector under condition of high neutron flux and γ ray background

    NASA Astrophysics Data System (ADS)

    Wang, Wen-Xin; Zhang, Yi; Wang, Ji-Jin; Hu, Bi-Tao

    2009-02-01

    In this paper Micromegas has been designed to detect neutrons. The simulation of the spatial resolution of Micromegas as neutron detector is carried out by GEANT4 toolkit. The neutron track reconstruction method based on the time coincidence technology is employed in the present work. The influence of the flux of incident 14 MeV neutron and high gamma background on the spatial resolution is carefully studied. Our results show that the spatial resolution of the detector is sensitive to the neutron flux, but insensitive to the intensity of γ background if the neutron track reconstruction method proposed by our group is used. The γ insensitivity makes it possible for us to use the Micromegas detector under condition which has high γ-rays background.

  18. Experimental investigation of the forces and moments due to sideslip of a series of triangular vertical and horizontal tail combinations at Mach numbers

    NASA Technical Reports Server (NTRS)

    Coletti, Donald E

    1954-01-01

    An experimental investigation was made at Mach numbers of 1.62, 1.93, and 2.41 of a series of tail combinations consisting of triangular vertical tail attached symmetrically to a triangular horizontal tail to determine the lateral force, yawing moment, and rolling moment due to sideslip. The apex angles of both the vertical- and horizontal-tail surfaces were varied systematically in order to obtain results for an appreciable range of operating conditions. The results of the investigation indicated that, for tails having subsonic leading edges and supersonic trailing edges, the lateral-force derivative and the yawing-moment derivative were predicted satisfactorily by the method presented in NACA TN 3071 except when the leading edges approach a sonic condition. The theoretical rolling-moment derivative was in fair agreement with the experimental derivative. For the limited tests in which both the leading and trailing edges were supersonic, the prediction of the lateral-force derivative and the yawing-moment derivative obtained from NACA TN 2412 was in good agreement with the experimental derivatives, whereas the prediction of the rolling-moment derivative was fair.

  19. Physical dose distribution due to multi-sliced kV X-ray beam in labeled tissue-like media: an experimental approach.

    PubMed

    Ghasemi, M; Kakuee, O R; Fathollahi, V; Shahvar, A; Mohati, M; Ghafoori, M

    2011-02-01

    Radiotherapy remains a major modality of cancer therapy. Thanks to high flux and high brilliance of synchrotron-generated X-ray, laboratory research with planar microscopically thin X-ray beam promise exciting new opportunities for treatment of cancer. High tolerance of normal tissues at doses up to several hundred Gy in a single dose fraction and preferential damage of tumors at very high doses have been uniquely observed in animal models exposed to microbeams. The fact that beams as thick as 0.68 mm could retain a part of these effects, opens the possibility that the required beam can be produced by high power X-ray tubes besides a dedicated synchrotron. Fortunately, dose distribution due to kilovolt X-rays could be enhanced by the introduction of high-Z contrast agents to tissue-like media. In this work, dose deposition in a phantom--partially loaded with Au and I as contrast agents--irradiated by multi-sliced kV X-ray beam was experimentally investigated in the peak and valley regions both on the surface and in the depth of phantom. The results of experimental dosimetry using Gaf-chromic films were compared with corresponding Monte-Carlo simulation. Relative reduction in the deposited dose in the peak regions downstream the area containing contrast agents in comparison with the adjacent areas was experimentally observed.

  20. A Quasi-Experimental Study into the Relations between Families' Social and Cultural Background and Children's Creche Experience and Global Cognitive Competence in Primary School

    ERIC Educational Resources Information Center

    Burger, Kaspar

    2012-01-01

    This study analysed the role of both sociocultural background and exposure to a creche on children's development of cognitive competence in Switzerland. Data were derived from a survey on children's cognitive proficiency after enrolment to primary school. Correlations and multiple linear regressions indicate that creche experience was not related…

  1. Consequences of VanE-type resistance on efficacy of glycopeptides in vitro and in experimental endocarditis due to Enterococcus faecalis.

    PubMed

    Lafaurie, M; Perichon, B; Lefort, A; Carbon, C; Courvalin, P; Fantin, B

    2001-10-01

    The consequences on glycopeptide activity of low-level resistance to vancomycin due to VanE-type resistance were evaluated in vitro and in experimental endocarditis caused by Enterococcus faecalis BM4405 (MICs of vancomycin and teicoplanin: 16 and 0.5 microg/ml, respectively), its susceptible derivative BM4405-1, and susceptible E. faecalis JH2-2. After 24 h of incubation, vancomycin at 8 microg/ml was not active against E. faecalis BM4405 whereas it was bacteriostatic against strains BM4405-1 and JH2-2. Against all three strains, vancomycin at 30 microg/ml and teicoplanin at 8 or 30 microg/ml were bacteriostatic but bactericidal when combined with gentamicin. In rabbits with aortic endocarditis due to VanE-type resistant strain BM4405, treatment with a standard dose of vancomycin generated subinhibitory plasma concentrations (i.e., peak of 36.3 +/- 2.1 microg/ml and trough of 6.0 +/- 2.2 microg/ml) and led to no significant reduction in mean aortic valve vegetation counts compared to no treatment of control animals. In contrast, a higher dosing regimen of vancomycin (i.e., resulting in a peak of 38.3 +/- 5.2 microg/ml and a trough of 15.0 +/- 8.3 microg/ml), providing plasma concentrations above the MIC for the entire dosing interval, led to significant and similar activities against all three strains, which were enhanced by combination with gentamicin. Treatment with teicoplanin led to results similar to those obtained with vancomycin at a high dose. No subpopulations with increased resistance to glycopeptides were selected in vitro or in vivo. In conclusion, the use of a high dose of vancomycin was necessary for the treatment of experimental enterococcal endocarditis due to VanE-type strains.

  2. Electron heating enhancement due to plasma series resonance in a capacitively coupled RF discharge: Electrical modeling and comparison to experimental measurements

    NASA Astrophysics Data System (ADS)

    Cao, Minglu; Lu, Yijia; Cheng, Jia; Ji, Linhong

    2016-09-01

    The electron heating enhancement due to the self-excitation of the plasma series resonance in capacitively coupled plasmas is revisited by a combination of an equivalent circuit model and experiments. To improve the model accuracy, measured voltage waveforms at the powered electrode are used instead of prescribing a sinusoidal voltage supply in series with a bias capacitance. The results calculated from the electrical model are consistent with the experimental measurements performed by a Langmuir probe with verification of a microwave interferometer, at pressures of 0.2 and 0.3 Torr. High harmonics occurring in the discharge currents agree with observations in previous research. The nonlinear plasma series resonance effect is found to have a notable contribution to both ohmic and stochastic heating evaluated by the electron heating efficiencies.

  3. The conductive hearing loss due to an experimentally induced middle ear effusion alters the interaural level and time difference cues to sound location.

    PubMed

    Thornton, Jennifer L; Chevallier, Keely M; Koka, Kanthaiah; Lupo, J Eric; Tollin, Daniel J

    2012-10-01

    Otitis media with effusion (OME) is a pathologic condition of the middle ear that leads to a mild to moderate conductive hearing loss as a result of fluid in the middle ear. Recurring OME in children during the first few years of life has been shown to be associated with poor detection and recognition of sounds in noisy environments, hypothesized to result due to altered sound localization cues. To explore this hypothesis, we simulated a middle ear effusion by filling the middle ear space of chinchillas with different viscosities and volumes of silicone oil to simulate varying degrees of OME. While the effects of middle ear effusions on the interaural level difference (ILD) cue to location are known, little is known about whether and how middle ear effusions affect interaural time differences (ITDs). Cochlear microphonic amplitudes and phases were measured in response to sounds delivered from several locations in azimuth before and after filling the middle ear with fluid. Significant attenuations (20-40 dB) of sound were observed when the middle ear was filled with at least 1.0 ml of fluid with a viscosity of 3.5 Poise (P) or greater. As expected, ILDs were altered by ~30 dB. Additionally, ITDs were shifted by ~600 μs for low frequency stimuli (<4 kHz) due to a delay in the transmission of sound to the inner ear. The data show that in an experimental model of OME, ILDs and ITDs are shifted in the spatial direction of the ear without the experimental effusion.

  4. Experimental and Model Study of Changes in Spectral Solar Irradiance in the Atmosphere of Large City due to Tropospheric NO{sub 2} Content

    SciTech Connect

    Chubarova, N. Ye.; Lebedev, V. V.; Partola, V. S.; Larin, I. K.; Lezina, Ye. A.; Rublev, A. N.

    2009-03-11

    An experimental and model approach has been used to study the NO{sub 2} vertical profiles and its effect on solar irradiance. The profiles of NO{sub 2} were obtained using gas analyzers, which had been installed at different levels at the Moscow State University (MSU) located at the south-western part of Moscow and at the Ostankino tower located at the north of Moscow up to the height of 350 m. Using these data diurnal and spatial variability of the NO{sub 2} content in the most polluted part of planetary boundary layer (PBL) has been analyzed within the large megalopolis. On the base of photochemical modeling we have simulated the diurnal cycle of NO{sub 2} vertical profiles for summer and winter conditions and have compared the results with the experimental ones. Using the RT modeling with input gaseous and aerosol parameters of the atmosphere obtained from the MSU Meteorological Observatory we have estimated the attenuation of spectral solar irradiance in UV and visible region of spectrum due to the NO{sub 2} content in the polluted atmosphere for different seasons.

  5. [Efficacy of cefixime and cefepime vs. other cephalosporins in experimental plague of albino mice due to variants FI+ and FI- of the plague microbe].

    PubMed

    Ryzhko, I V; Shcherbaniuk, A I; Moldavan, I A; Tsuraeva, R I; Anisimov, B I; Trishina, A V

    2007-01-01

    Efficacy of cefixime and cefepime vs. ceftriaxone, cefotaxime, ceftazidime and cefoperazone was studied in vitro and in the treatment of experimental plague of albino mice due to natural, antigen complete strains of the plague microbe and the pathogen variants deprived of the ability to produce the capsule antigen fraction I (FI- phenotype). The MICs of cefixime and cefepime for 20 FI+ and 20 FI- strains of the plague microbe were 0.02-0.08 mg/l, that corresponded to the MICs of ceftriaxone, cefotaxime and ceftazidime. The MICs of cefoperazone were somewhat higher (0.1-0.2 mg/l). The ED50 values of cefixime and cefepime for prevention and treatment of experimental plague in mice statistically did not significantly differ from the ED50 values of ceftriaxone, cefotaxime, ceftazidime and cefoperazone. The efficacy indices (EIs) of cefixime and cefepime were > 10(4) independent of the infective strain phenotype (FI+ or FI-) and did not differ from those of ceftriaxone and ceftazidime. The efficacy of cefotaxime and cefoperazone was somewhat lower (EIs 1.7 x 10(3)-8.9 x 10(3)). Both the antibacterials were shown to provide high protective and therapeutic efficacy (80-100% of the survivors) independent of the phenotype (FI+ or FI-) of the pathogen infective strain. The results allowed to consider the antibiotics prospective in prevention and treatment of plague.

  6. Experimental estimation of tungsten impurity sputtering due to Type I ELMs in JET-ITER-like wall using pedestal electron cyclotron emission and target Langmuir probe measurements

    NASA Astrophysics Data System (ADS)

    Guillemaut, C.; Jardin, A.; Horacek, J.; Borodkina, I.; Autricque, A.; Arnoux, G.; Boom, J.; Brezinsek, S.; Coenen, J. W.; De La Luna, E.; Devaux, S.; Eich, T.; Harting, D.; Kirschner, A.; Lipschultz, B.; Matthews, G. F.; Meigs, A.; Moulton, D.; O'Mullane, M.; Stamp, M.; contributors, JET

    2016-02-01

    The ITER baseline scenario, with 500 MW of DT fusion power and Q = 10, will rely on a Type I ELMy H-mode and will be achieved with a tungsten (W) divertor. W atoms sputtered from divertor targets during mitigated ELMs are expected to be the dominant source in ITER. W impurity concentration in the plasma core can dramatically degrade its performance and lead to potentially damaging disruptions. Understanding the physics of the target W source due to sputtering during ELMs and inter-ELMs is important and can be helped by experimental measurements with improved precision. It has been established that the ELMy target ion impact energy has a simple linear dependence with the pedestal electron temperature measured by Electron Cyclotron Emission (ECE). It has also been shown that Langmuir Probes (LP) ion flux measurements are reliable during ELMs due to the surprisingly low electron temperature. Therefore, in this paper, LP and ECE measurements in JET-ITER-Like-Wall (ILW) unseeded Type I ELMy H-mode experiments have been used to estimate the W sputtering flux from divertor targets in ELM and inter-ELM conditions. Comparison with similar estimates using W I spectroscopy measurements shows a reasonable agreement for the ELM and inter-ELM W source. The main advantage of the method involving LP measurements is the very high time resolution of the diagnostic (˜10 μs) allowing very precise description of the W sputtering source during ELMs.

  7. Efficacies of colistin and tigecycline in mice with experimental pneumonia due to NDM-1-producing strains of Klebsiella pneumoniae and Escherichia coli.

    PubMed

    Docobo-Pérez, Fernando; Nordmann, Patrice; Domínguez-Herrera, Juan; López-Rojas, Rafael; Smani, Younes; Poirel, Laurent; Pachón, Jerónimo

    2012-03-01

    New Delhi metallo-β-lactamase-1 (NDM-1)-producing Enterobacteriaceae have emerged as a global threat. The aim of this study was to assess the efficacies of colistin and tigecycline in an experimental model of pneumonia caused by NDM-1-producing Escherichia coli and Klebsiella pneumoniae. The susceptibilities of K. pneumoniae NDM, E. coli NDM and K. pneumoniae ATCC 29665 were determined using the broth microdilution technique. The pharmacokinetics of colistin and tigecycline in an experimental model of pneumonia were performed using immunocompetent C57BL/6 mice. Mice were treated with colistin (60 mg/kg/day) or tigecycline (10 mg/kg/day). Mortality, bacteraemia and lung bacterial concentrations were recorded. The strains were susceptible to colistin and tigecycline. The ratio of area under the concentration-time curve/minimum inhibitory concentration (AUC/MIC) for colistin was 158.5 (all three strains) and that for tigecycline was 18.5 (K. pneumoniae NDM) and 37 (K. pneumoniae ATCC 29665 and E. coli NDM). In vivo, colistin decreased bacterial lung concentrations of K. pneumoniae NDM and K. pneumoniae ATCC 29665 by 1.16 log colony-forming units (CFU)/g and 2.23 logCFU/g, respectively, compared with controls (not significant). Tigecycline reduced K. pneumoniae NDM and K. pneumoniae ATCC 29665 load by 2.67 logCFU/g and 4.62 logCFU/g (P<0.05). Colistin and tigecycline decreased lung concentrations of E. coli NDM by 2.27 logCFU/g and 4.15 logCFU/g (P<0.05), respectively, compared with controls, and was more active than colistin (P<0.05). In conclusion, these results suggest that colistin is inappropriate for treating pneumonia due to NDM-1-producing K. pneumoniae and its efficacy was suboptimal against NDM-1-producing E. coli. A high tigecycline dose was efficacious for treating experimental pneumonia due to NDM-1-producing E. coli and K. pneumoniae. Copyright © 2011 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.

  8. Experimental study of the atmospheric neutrino backgrounds for p{yields}e{sup +}{pi}{sup 0} searches in water Cherenkov detectors

    SciTech Connect

    Mine, S.; Casper, D.; Kropp, W.; Smy, M.; Sobel, H.; Vagins, M.; Alcaraz, J. L.; Andringa, S.; Espinal, X.; Fernandez, E.; Jover, G.; Nova, F.; Rodriguez, A.; Sanchez, F.; Aoki, S.; Asakura, K.; Hara, T.; Moriguchi, Y.; Sekiguchi, M.; Suzuki, A.

    2008-02-01

    The atmospheric neutrino background for proton decay via p{yields}e{sup +}{pi}{sup 0} in ring imaging water Cherenkov detectors is studied with an artificial accelerator neutrino beam for the first time. In total, 3.14x10{sup 5} neutrino events corresponding to about 10 megaton-years of atmospheric neutrino interactions were collected by a 1000 ton water Cherenkov detector (KT). The KT charged-current single {pi}{sup 0} production data are well reproduced by simulation programs of neutrino and secondary hadronic interactions used in the Super-Kamiokande (SK) proton decay search. The obtained p{yields}e{sup +}{pi}{sup 0} background rate by the KT data for SK from the atmospheric neutrinos whose energies are below 3 GeV is 1.63{sub -0.33}{sup +0.42}(stat){sub -0.51}{sup +0.45}(syst)(megaton-year){sup -1}. This result is also relevant to possible future, megaton-scale water Cherenkov detectors.

  9. The effectiveness of a rotavirus vaccine in preventing hospitalizations and deaths presumably due to acute infectious diarrhea in Brazilian children: a quasi-experimental study.

    PubMed

    Teles, Estêvão; Moscovici, Leonardo; Monteiro, Rosane Aparecida; Alves, Domingos; Laprega, Milton Roberto; Bellissimo-Rodrigues, Fernando

    2015-01-01

    Rotavirus is the main etiologic agent of acute infectious diarrhea in children worldwide. Considering that a rotavirus vaccine (G1P8, strain RIX4414) was added to the Brazilian vaccination schedule in 2006, we aimed to study its effectiveness and safety regarding intestinal intussusception. A quasi-experimental trial was performed in which the primary outcome was the number of hospitalizations that were presumably due to acute infectious diarrhea per 100,000 children at risk (0-4 years old). The secondary outcomes included mortality due to acute infectious diarrhea and the intestinal intussusception rates in children in the same age range. We analyzed three scenarios: Health Division XIII of the State of São Paulo (DRS XIII) from 2002 to 2008, the State of São Paulo, and Brazil from 2002 to 2012. The averages of the hospitalization rates for 100,000 children in the pre- and post-vaccination periods were 1,413 and 959, respectively, for DRS XIII (RR=0.67), 312 and 249, respectively, for the State of São Paulo (RR=0.79), and 718 and 576, respectively, for Brazil (RR=0.8). The mortality rate per 100,000 children in the pre- and post-vaccination periods was 2.0 and 1.3, respectively, for DRS XIII (RR=0.66), 5.5 and 2.5, respectively, for the State of São Paulo (RR=0.47), and 15.0 and 8.0, respectively, for Brazil (RR=0.53). The average annual rates of intussusception for 100,000 children in DRS XIII were 28.0 and 22.0 (RR=0.77) in the pre- and post-vaccination periods, respectively. A monovalent rotavirus vaccine was demonstrated to be effective in preventing the hospitalizations and deaths of children that were presumably due to acute infectious diarrhea, without increasing the risk of intestinal intussusception.

  10. Experimental study of a co-flowing jet in ONERA’s F2 research wind tunnel by 3D background oriented schlieren

    NASA Astrophysics Data System (ADS)

    Nicolas, F.; Donjat, D.; Plyer, A.; Champagnat, F.; Le Besnerais, G.; Micheli, F.; Cornic, P.; Le Sant, Y.; Deluc, J. M.

    2017-08-01

    This paper describes the first application of 3D density reconstruction from a limited number of background oriented schlieren (BOS) images in a large research-type low speed wind tunnel. The tested flow is an ad hoc co-flowing hot jet generated at the wingtip of a simplified airfoil. Ray deviation maps captured by 12 synchronized cameras are combined to reconstruct the three dimensional density field of the jet, in the line of the direct 3D BOS technique described in Nicolas et al (2016 Exp. Fluids 57 1-21). A comparison with thermocouple sampling shows consistent results and highlights the efficiency of this new method for thermal measurement of a low speed convective flow. Finally, we underline the new possibilities for fluid dynamic characterization offered by combining stereo particle image velocimetry and 3D BOS measurements.

  11. Daptomycin plus fosfomycin, a synergistic combination in experimental implant-associated osteomyelitis due to methicillin-resistant Staphylococcus aureus in rats.

    PubMed

    Lingscheid, Tilman; Poeppl, Wolfgang; Bernitzky, Dominik; Veletzky, Luzia; Kussmann, Manuel; Plasenzotti, Roberto; Burgmann, Heinz

    2015-02-01

    The aim of this study was to evaluate the combination of daptomycin and fosfomycin in experimental chronic implant-associated osteomyelitis due to methicillin-resistant Staphylococcus aureus (MRSA). Infection was induced in the tibiae of rats by the insertion of a bacterial inoculum (1 to 5×10(8) CFU/ml) of a clinical MRSA isolate and a titanium wire. Four weeks after infection, each animal was assigned to a treatment group: daptomycin monotherapy at 60 mg/kg of body weight once daily (n=10), fosfomycin monotherapy at 40 mg/kg once daily (n=10), or daptomycin and fosfomycin combined at 60 mg/kg and 40 mg/kg, respectively, once daily (n=9). Ten animals were left untreated. After a 3-week treatment period, the animals were euthanized, and the infected tibiae and implants were processed for quantitative bacterial cultures. The bacterial cultures from bones were positive for MRSA in all animals in the untreated group, the daptomycin group, and the fosfomycin group, with median bacterial counts of 2.34×10(6) CFU/g bone, 1.57×10(6) CFU/g bone, and 3.48×10(2) CFU/g bone, respectively. In the daptomycin-fosfomycin group, 6 out of 9 animals were positive for MRSA, with a median count of 7.92 CFU/g bone. Bacterial cultures derived from the titanium wires were negative in the fosfomycin- and daptomycin-fosfomycin-treated groups. Based on bacterial counts in bones, treatment with daptomycin-fosfomycin was statistically significantly superior to all that of the other groups (P≤0.003). Fosfomycin was superior to daptomycin and no treatment (P<0.0001). No development of resistance was observed in any treatment arm. The combination of daptomycin and fosfomycin demonstrated synergism against MRSA in experimental implant-associated osteomyelitis.

  12. Apparent partial resetting of U-Th-Pb systems in experimentally altered monazite resulting from nano-mixtures due to incomplete replacement.

    NASA Astrophysics Data System (ADS)

    Grand'homme, Alexis; Janots, Emilie; Seydoux-Guillaume, Anne-Magali; Guillaume, Damien; Bosse, Valérie; Magnin, Valérie

    2016-04-01

    Hydrothermal alteration experiments of natural monazite crystals (Manangotry, Madagascar; 555 Ma) under alkali conditions (NaOH 1M in 18O doped solution) at low temperature conditions (300, 400, 500 and 600°C), 200 MPa, were conducted to clarify the origin of unsupported Pb (radiogenic or not) in altered monazite (Seydoux-Guillaume et al., 2012). At 300°C, no evidence of monazite replacement was observed. From 400 to 600°C, experimental products show a replacement texture with pristine monazite (Mnz1) surrounded by an alteration rim with a different composition (SEM and EPMA). In the altered domains, in-situ isotopic and chemical U-Th-Pb dating yields intermediate ages between original monazite (555 Ma) and complete experimental resetting (0 Ma). Incomplete resetting is due to the systematic presence of Pb in altered domains, whose concentration decreases with increasing temperature. Transmission Electron Microscope (TEM) observations reveal an incomplete replacement of Mnz1 by a secondary monazite (Mnz2), free of Pb, within the altered domain. The latter domain, apparently homogeneous in BSE images, is in fact constituted by closely associated nano-mixtures of Mnz1 and Mnz2. Furthermore, the volume of Mnz2 within the altered domain, i.e. the efficiency of replacement, increases with increasing temperature. Apparent partial resetting of U-Th-Pb systems results from the unavoidable nano-mixture of different proportion of Mnz1 and Mnz2 within the analytical microvolume (EPMA, LA-ICP-MS). This study therefore indicates that the micrometric resolution (even the 5 μm3 for EPMA) of in-situ dating techniques may be not sufficient to solve such nano-replacement domains, especially when alteration occurs at low-temperature. Ref: Seydoux-Guillaume, A.-M., Montel, J.-M., Bingen, B., Bosse, V., de Parseval, P., Paquette, J.-L., Janots, E., and Wirth, R., (2012). Chemical Geology, v. 330-331, p. 140-158.

  13. Background Strain and the Differential Susceptibility of Podocyte-Specific Deletion of Myh9 on Murine Models of Experimental Glomerulosclerosis and HIV Nephropathy

    PubMed Central

    Johnstone, Duncan B.; Ikizler, Omer; Zhang, Jidong; Holzman, Lawrence B.

    2013-01-01

    We previously reported that podocyte-specific deletion of Myh9 (conventional myosin heavy chain 2A) in C57BL/6 mice does not cause spontaneous kidney disease but instead results in a predisposition to glomerulosclerosis in response to a second model of glomerular injury. In contrast, other investigators reported that podocyte-specific deletion of Myh9 (PodΔMyh9) resulted in spontaneous glomerulosclerosis in mice on a mixed background, suggesting that the glomerulosclerosis is dependent on background strain. In order to elucidate the cause of this strain dependent effect Podocin::Cre and Myh9flox alleles were backcrossed to mouse strain FVB/N, which is highly susceptible to glomerulosclerosis, with the aim of intercrossing susceptible FVB/N and resistant C57BL/6 mice in subsequent congenic analyses. However, after backcrossing mice to FVB/N and aging mice to 28 weeks, we found no evidence of glomerular disease in PodΔMyh9 mice vs control littermates (urine MAC ratio all p>0.05). We also tested C57BL/6 PodΔMyh9 mice for a predisposition to injury from models other than Adriamycin including HIV nephropathy (HIVAN), puromycin nephropathy, and sheep nephrotoxic serum. In the Tg26 model of HIVAN, we found that podocyte-specific deletion of Myh9 resulted in a modest hypersensitivity in adults compared to Tg26+ control littermates (urine MAC ratio, p<0.05 or less). In contrast, we found that PodΔMyh9 mice were not predisposed to injury in response to other injury models including puromycin nephropathy and sheep nephrotoxic serum. While the mechanism of injury in these models is not fully understood, we conclude that PodΔMyh9 results in a variable susceptibility to glomerulosclerosis in response to different models of glomerular injury. In addition, based on the lack of a spontaneous phenotype of glomerulosclerosis in both C57BL/6 and FVB/N mice, we propose that Myh9 is not absolutely required in adult podocytes. PMID:23874454

  14. Efficacies of Imipenem, Meropenem, Cefepime, and Ceftazidime in Rats with Experimental Pneumonia Due to a Carbapenem-Hydrolyzing β-Lactamase-Producing Strain of Enterobacter cloacae

    PubMed Central

    Mimoz, Olivier; Leotard, Sophie; Jacolot, Anne; Padoin, Christophe; Louchahi, Kamel; Petitjean, Olivier; Nordmann, Patrice

    2000-01-01

    The antibacterial activities of imipenem-cilastatin, meropenem-cilastatin, cefepime and ceftazidime against Enterobacter cloacae NOR-1, which produces the carbapenem-hydrolyzing β-lactamase NmcA and a cephalosporinase, and against one of its in vitro-obtained ceftazidime-resistant mutant were compared by using an experimental model of pneumonia with immunocompetent rats. The MICs of the β-lactams with an inoculum of 5 log10 CFU/ml were as follows for E. cloacae NOR-1 and its ceftazidime-resistant mutant, respectively: imipenem, 16 and 128 μg/ml, meropenem, 4 and 32 μg/ml, cefepime, <0.03 and 1 μg/ml, and ceftazidime, 1 and 512 μg/ml. The chromosomally located cephalosporinase and carbapenem-hydrolyzing β-lactamase NmcA were inducible by cefoxitin and meropenem in E. cloacae NOR-1, and both were stably overproduced in the ceftazidime-resistant mutant. Renal impairment was induced (uranyl nitrate, 1 mg/kg of body weight) in rats to simulate the human pharmacokinetic parameters for the β-lactams studied. Animals were intratracheally inoculated with 8.5 log10 CFU of E. cloacae, and therapy was initiated 3 h later. At that time, animal lungs showed bilateral pneumonia containing more than 6 log10 CFU of E. cloacae per g of tissue. Despite the relative low MIC of meropenem for E. cloacae NOR-1, the carbapenem-treated rats had no decrease in bacterial counts in their lungs 60 h after therapy onset compared to the counts for the controls, regardless of whether E. cloacae NOR-1 or its ceftazidime-resistant mutant was inoculated. A significant decrease in bacterial titers was observed for the ceftazidime-treated rats infected with E. cloacae NOR-1 only. Cefepime was the only β-lactam tested effective as treatment against infections due to E. cloacae NOR-1 or its ceftazidime-resistant mutant. PMID:10722486

  15. Therapeutic Effect of Human Adipose Tissue-Derived Mesenchymal Stem Cells in Experimental Corneal Failure Due to Limbal Stem Cell Niche Damage.

    PubMed

    Galindo, Sara; Herreras, José M; López-Paniagua, Marina; Rey, Esther; de la Mata, Ana; Plata-Cordero, María; Calonge, Margarita; Nieto-Miguel, Teresa

    2017-10-01

    Limbal stem cells are responsible for the continuous renewal of the corneal epithelium. The destruction or dysfunction of these stem cells or their niche induces limbal stem cell deficiency (LSCD) leading to visual loss, chronic pain, and inflammation of the ocular surface. To restore the ocular surface in cases of bilateral LSCD, an extraocular source of stem cells is needed to avoid dependence on allogeneic limbal stem cells that are difficult to obtain, isolate, and culture. The aim of this work was to test the tolerance and the efficacy of human adipose tissue-derived mesenchymal stem cells (hAT-MSCs) to regenerate the ocular surface in two experimental models of LSCD that closely resemble different severity grades of the human pathology. hAT-MSCs transplanted to the ocular surface of the partial and total LSCD models developed in rabbits were well tolerated, migrated to inflamed tissues, reduced inflammation, and restrained the evolution of corneal neovascularization and corneal opacity. The expression profile of the corneal epithelial cell markers CK3 and E-cadherin, and the limbal epithelial cell markers CK15 and p63 was lost in the LSCD models, but was partially recovered after hAT-MSC transplantation. For the first time, we demonstrated that hAT-MSCs improve corneal and limbal epithelial phenotypes in animal LSCD models. These results support the potential use of hAT-MSCs as a novel treatment of ocular surface failure due to LSCD. hAT-MSCs represent an available, non-immunogenic source of stem cells that may provide therapeutic benefits in addition to reduce health care expenses. Stem Cells 2017;35:2160-2174. © 2017 AlphaMed Press.

  16. Modeling background intensity in DNA microarrays

    NASA Astrophysics Data System (ADS)

    Kroll, K. M.; Barkema, G. T.; Carlon, E.

    2008-06-01

    DNA microarrays are devices that are able, in principle, to detect and quantify the presence of specific nucleic acid sequences in complex biological mixtures. The measurement consists in detecting fluorescence signals from several spots on the microarray surface onto which different probe sequences are grafted. One of the problems of the data analysis is that the signal contains a noisy background component due to nonspecific binding. We present a physical model for background estimation in Affymetrix Genechips. It combines two different approaches. The first is based on the sequence composition, specifically its sequence-dependent hybridization affinity. The second is based on the strong correlation of intensities from locations which are the physical neighbors of a specific spot on the chip. Both effects are incorporated in a background estimator which contains 24 free parameters, fixed by minimization on a training data set. In all data analyzed the sequence-specific parameters, obtained by minimization, are found to strongly correlate with empirically determined stacking free energies for RNA-DNA hybridization in solution. Moreover, there is an overall agreement with experimental background data and we show that the physics-based model that we propose performs on average better than purely statistical approaches for background calculations. The model thus provides an interesting alternative method for background subtraction schemes in Affymetrix Genechips.

  17. Biophoton Emission:. Experimental Background and Theoretical Approaches

    NASA Astrophysics Data System (ADS)

    Popp, Fritz-Albert; Gu, Qiao; Li, Ke-Hsueh

    Biophoton emission is a general phenomenon of living systems. It concerns a weak photon radiation from a few to some hundred photons per second, per square centimeter surface area, at least within the spectral region from 200 to 800 nm. The results indicate that biophoton emission can be assigned to a coherent field within living organisms, its functions being intra and intercellular regulation and communication. This review deals with some central results and their interpretation.

  18. Experimental study of sediment-CO2 reactions with application to changes in groundwater quality due to leakage of sequestered CO2

    NASA Astrophysics Data System (ADS)

    Carey, J. W.; Williams, M. R.; Hakala, A.; Fessenden, J. E.; Keating, E. H.

    2009-12-01

    Geologic sequestration of CO2 requires storage of buoyant, immiscible supercritical CO2 in the subsurface for long periods of time. In the viability assessment of sequestration, one of the most significant risk concerns is damage of shallow drinking water aquifers from potential CO2 leakage. The groundwater quality concerns are primarily due to acidification, increase in total dissolved solids (TDS), and the potential mobilization of hazardous trace metals. Previous studies of this issue include natural analogs of CO2-groundwater interactions where there can be uncertainty as to whether observations reflect variations in groundwater quality unrelated to CO2 and numerical studies of CO2-brine interactions with shallow aquifers where there is uncertainty as to the geochemical mechanisms of trace element mobilization. In this study, we conduct experiments of CO2-water-sediment interactions from the Chimayo region in north-central New Mexico. This region includes a natural CO2 seep which we have used in natural analog studies (Keating et al. 2009) and the presence of elevated arsenic and uranium concentrations. The experiments were designed to address the question of whether CO2 reactions with aquifer sediments could account for the observed water quality problems in Chimayo and to consider the more general question of the nature of trace element mobilization by CO2-induced reactions. The experiments consisted of periodically sampled batch reactions of water and sediment reacted with a continuous source of 1-atm CO2. The sediments are quartz-rich alluvial fan deposits that include feldspars and clays and were characterized by XRD, XRF, and by sequential extraction to determine trace metal content. The water was created to represent the background major ion chemistry of groundwater in the region. The sediments were initially equilibrated with the synthetic water prior to introduction of CO2. Reaction with CO2 was monitored over 10 days with periodic fluid sampling. The

  19. Mismatch-induced lethality due to a defect in Escherichia coli RecQ helicase in exonuclease-deficient background: Dependence on MutS and UvrD functions.

    PubMed

    Yamana, Yoshimasa; Sonezaki, Shuji; Ogawa, Hiroaki I; Kusano, Kohji

    2010-05-01

    Escherichia coli DNA-unwinding protein RecQ has roles in the regulation of general recombination and the processing of stalled replication forks. In this study, we found that knockout of the recQ gene in combination with xonA xseA recJ mutations, which inhibit methyl-directed mismatch repair (MMR), caused about 100-fold increase in sensitivity to a purine analog 2-aminopurine (2AP). Intriguingly, inactivation of a MMR initiator due to the either mutation mutS or uvrD completely suppressed the 2AP sensitivity caused by recQ xonA xseA recJ mutations, suggesting that RecQ helicase might act on the DNA structures that are generated by the processing of DNA by the MutSLH complex and UvrD helicase. Moreover, the recQ gene knockout in combination with xonA xseA recJ mutations enhanced 2AP-induced filament formation, and increased by twofold the rate of spontaneous forward mutations in the thyA locus but did not increase the rate of rifampicin-resistant mutations. We discuss about the possible interplay between E. coli RecQ helicase and mismatch recognition factors.

  20. Evaluation of physical health effects due to volcanic hazards: the use of experimental systems to estimate the pulmonary toxicity of volcanic ash

    SciTech Connect

    Martin, T.R.; Wehner, A.P.; Butler, J.

    1986-03-01

    Shortly after Mount St. Helens erupted in 1980, a number of laboratories began to investigate the effects of volcanic ash in a variety of experimental systems in attempts to predict effects that might occur in the lung of humans exposed to volcanic ash. The published results are remarkably consistent, despite the use of non-uniform ash samples and variability in the experimental approaches used. The data indicate that volcanic ash, even in high concentrations, causes little toxicity to lung cells in vitro and in vivo, as compared with effects of free crystalline silica, which is known to be highly fibrogenic. Volcanic ash does not appear to be entirely inert, however, possibly because of low concentrations of free crystalline silica in the ash. The published experimental studies suggest that inhaled volcanic ash is not likely to be harmful to the lungs of healthy humans, but the potential effects of volcanic ash in patients with pre-existing lung diseases are more difficult to ascertain from these studies.

  1. Qualitative analysis of anatomopathological changes of gastric mucosa due to long term therapy with proton pump inhibitors: experimental studies x clinical studies.

    PubMed

    de Souza, Iure Kalinine Ferraz; da Silva, Alcino Lázaro; de Araújo, Alex; Santos, Fernanda Carolina Barbosa; Mendonça, Bernardo Pinto Coelho Keuffer

    2013-01-01

    For a few decades the long-term use of proton pump inhibitors has had wide application in the treatment of several gastrointestinal diseases. Since then, however, several studies have called attention to the possible development of anatomical and pathological changes of gastric mucosa, resulting from the long term use of this therapeutic modality. Recent experimental and clinical studies suggest that these changes have connection not only to the development of precancerous lesions, but also of gastric tumors. To present a qualitative analysis of anatomical and pathological changes of gastric mucosa resulting from the long-term use of proton pump inhibitors. The headings used were: proton pump inhibitors, precancerous lesions and gastric neoplasms for a non systematic review of the literature, based on Medline, Lillacs and Scielo. Twelve articles were selected from clinical (9) and experimental (3) studies, for qualitative analysis of the results. The gastric acid suppression by high doses of proton pump inhibitors induces hypergastrinemia and the consequent emergence of neuroendocrine tumors in animal models. Morphological changes most often found in these experimental studies were: enterochromaffin-like cell hyperplasia, neuroendocrine tumor, atrophy, metaplasia and adenocarcinoma. In the studies in humans, however, despite enterochromaffin-like cell hyperplasia, the other effects, neuroendocrine tumor and gastric atrophy, gastric metaplasia and or adenocarcinoma, were not identified. Although it is not possible to say that the long-term treatment with proton pump inhibitors induces the appearance or accelerates the development of gastric cancer in humans, several authors have suggested that prolonged administration of this drug could provoke the development of gastric cancer. Thus, the evidence demonstrated in the animal model as well as the large number of patients who do or will do a long-term treatment with proton pump inhibitors, justifies the maintenance of

  2. Detailed investigation of the phase transition in KxP4W8O32 and experimental arguments for a charge density wave due to hidden nesting

    NASA Astrophysics Data System (ADS)

    Kolincio, Kamil; Pérez, Olivier; Hébert, Sylvie; Fertey, Pierre; Pautrat, Alain

    2016-06-01

    Detailed structural and magnetotransport properties of monophosphate tungsten bronze Kx(PO2)4(WO3)8 single crystals are reported. Both galvanomagnetic and thermal properties are shown to be consistent with a charge density wave electronic transition due to hidden nesting of the quasi-1D portion of the Fermi surface. We also observe the enhancement of electronic anisotropy due to reconstruction of the Fermi surface at the Peierls transition. The resistivity presents a thermal hysteresis suggesting a first-order nature characteristic of a strong-coupling scenario. However, other measurements such as the change of carrier density demonstrate a second-order Peierls scenario with weak-coupling features. We suggest that the structural transition driven by the residual strain in the K-P-O environment is responsible for the resistivity hysteresis and modifies the Fermi surface which then helps the rise to the second-order Peierls instability.

  3. Net Loss of CaCO3 from a subtropical calcifying community due to seawater acidification: Mesocosm-scale experimental evidence

    USGS Publications Warehouse

    Andersson, A.J.; Kuffner, I.B.; MacKenzie, F.T.; Jokiel, P.L.; Rodgers, K.S.; Tan, A.

    2009-01-01

    Acidification of seawater owing to oceanic uptake of atmospheric CO 2 originating from human activities such as burning of fossil fuels and land-use changes has raised serious concerns regarding its adverse effects on corals and calcifying communities. Here we demonstrate a net loss of calcium carbonate (CaCO3) material as a result of decreased calcification and increased carbonate dissolution from replicated subtropical coral reef communities (N=3) incubated in continuous-flow mesocosms subject to future seawater conditions. The calcifying community was dominated by the coral Montipora capitata. Daily average community calcification or Net Ecosystem Calcification (NECC=CaCO3 production - dissolution) was positive at 3.3 mmol CaCO3 m-2 h-1 under ambient seawater pCO2 conditions as opposed to negative at -0.04 mmol CaCO3 m-2 h-1 under seawater conditions of double the ambient pCO2. These experimental results provide support for the conclusion that some net calcifying communities could become subject to net dissolution in response to anthropogenic ocean acidification within this century. Nevertheless, individual corals remained healthy, actively calcified (albeit slower than at present rates), and deposited significant amounts of CaCO3 under the prevailing experimental seawater conditions of elevated pCO2.

  4. Experimental and Numerical investigation of a droplet-laden turbulent flow: preferential concentration due to turbulence and its influence on droplet collisions and growth

    NASA Astrophysics Data System (ADS)

    Aliseda, Alberto; Bateson, Colin; Ayala, Orlando; Parishani, Hossein; Wang, Lian-Ping; Rosa, Bogdan

    2011-11-01

    We have conducted a multi-laboratory investigation of the dynamics of small inertial droplets (St ~ 0 . 1 - 1) immersed in homogeneous isotropic turbulence. We compare experimental results from a wind tunnel experiment with Direct Numerical Simulations of slowly decaying homogeneous isotropic turbulence laden with spherical droplets. The Reynolds number (Reλ) in both cases is of the order of 200 and the particle distribution is polydisperse with droplets in the 10 - 30 μm range. We compare the one-dimensional Radial Distribution Function from the experiments to the 1D, 2D and 3D RDFs from the simulations to validate the numerical treatment of the droplet dynamics in close proximity, and to develop methods to extrapolate the experimental measurements to 3D. We also compare the relative velocity of a pair of droplets, obtained along a line or in a plane from PDPA and PIV measurements, to the equivalent statistics obtained from the 3D velocity fields in the DNS. These are key components of the droplet collision kernel necessary to calculate turbulence-induced collision-coalescence and droplet growth.

  5. [Efficacy of levofloxacin, lomefloxacin and moxifloxacin vs. other fluoroquinolones in experimental plague due to FI+ and FI- strains of Yersinia pestis in Albino mice].

    PubMed

    Ryzhko, I V; Tsuraeva, R I; Anisimov, B I; Trishina, A V

    2009-01-01

    Activity of levofloxacin, lomefloxacin and moxifloxacin against 20 FI+ and 20 FI- strains of Yersinia pestis was studied. It was shown that the strains were highly susceptible to the fluoroquinolones. In the experiments on mice subcutaneously infected with suspension of strains 231 FI+ and 231 FI- of Y. pestis in a dose of about 1000 LD50 (10(4) microbial cells) the ED50 of levofloxacin and moxifloxacin was 5.5-14.0 mg/kg independent of the infective culture phenotype and that of lomefloxacin was 18.5 mg/kg. Estimation of the impact of the pathogen infective dose value on the results of the experimental plague treatment with the therapeutic dose equivalent to the human one showed high efficacy of the fluoroquinolones (efficacy index of 10(4)). The treatment for 7 days provided 90-100-percent survival of the animals. The prophylactive use of lomefloxacin (in 5 hours - 5 days) was less efficient (70-80% of the survivals) in the animals infected with the antigen-changed (FI-) variant of the pathogen. Levofloxacin and moxifloxacin provided 90-100-percent survival of the animals treated for a course of 5 days independent of the pathogen phenotype. The study demonstrated that the use oflevofloxacin, lomefloxacin and moxifloxacin was prospective for the prophylaxis and therapy of experimental plague.

  6. Unsteady loads due to propulsive lift configurations. Part D: The development of an experimental facility for the investigation of scaling effects on propulsive lift configurations

    NASA Technical Reports Server (NTRS)

    Haviland, J. K.; Herling, W. W.

    1978-01-01

    The design and construction of an experimental facility for the investigation of scaling effects in propulsive lift configurations are described. The facility was modeled after an existing full size NASA facility which consisted of a coaxial turbofan jet engine with a rectangular nozzle in a blown surface configuration. The flow field of the model facility was examined with and without a simulated wing surface in place at several locations downstream of the nozzle exit plane. Emphasis was placed on obtaining pressure measurements which were made with static probes and surface pressure ports connected via plastic tubing to condenser microphones for fluctuating measurements. Several pressure spectra were compared with those obtained from the NASA facility, and were used in a preliminary evaluation of scaling laws.

  7. Inhibition of Na(+),K(+)-ATPase in the hypothalamus, pons and cerebellum of the offspring rat due to experimentally-induced maternal hypothyroidism.

    PubMed

    Koromilas, Christos; Liapi, Charis; Zarros, Apostolos; Tsela, Smaragda; Zissis, Konstantinos M; Kalafatakis, Konstantinos; Skandali, Nikolina; Voumvourakis, Konstantinos; Carageorgiou, Haris; Tsakiris, Stylianos

    2015-08-01

    Neurodevelopment is known to be particularly susceptible to thyroid hormone insufficiency and can result in extensive structural and functional deficits within the central nervous system (CNS), subsequently leading to the establishment of cognitive impairment and neuropsychiatric symptomatology. The current study evaluated the effects of gestational and/or lactational maternal exposure to propylthiouracil (PTU)-induced hypothyroidism (as a suggestive multilevel experimental approach to the study of hypothyroidism-induced changes that has been developed and characterized by the authors) on crucial brain enzyme activities of 21-day-old Wistar rat offspring in a CNS region-specific manner. The activities of acetylcholinesterase (AChE), Na(+),K(+)-ATPase and Mg(2+)-ATPase in the offspring hypothalamus, cerebellum and pons were assessed. The study demonstrated that maternal exposure to PTU (0.05% w/v in the drinking water) during the critical periods of neurodevelopment can result in an inhibition of hypothalamic, pontine and cerebellar Na(+),K(+)-ATPase; a major marker of neuronal excitability and metabolic energy production as well as an important regulator of important systems of neurotransmission. On the other hand, no significant changes in the activities of the herein offspring CNS regions' AChE and Mg(2+)-ATPase were recorded. The observed Na(+),K(+)-ATPase inhibition: (i) is region-specific (and non-detectable in whole brain homogenetes), (ii) could constitute a central event in the pathophysiology of clinically-relevant hypothyroidism-associated developmental neurotoxicity, (iii) occurs under all examined experimental schemes, and (iv) certainly deserves further clarification at a molecular and histopathological level. As these findings are analyzed and compared to the available literature, they also underline the need for the adoption and further study of Na(+),K(+)-ATPase activity as a consistent neurochemical marker within the context of a systematic

  8. Daptomycin or teicoplanin in combination with gentamicin for treatment of experimental endocarditis due to a highly glycopeptide-resistant isolate of Enterococcus faecium.

    PubMed Central

    Caron, F; Kitzis, M D; Gutmann, L; Cremieux, A C; Maziere, B; Vallois, J M; Saleh-Mghir, A; Lemeland, J F; Carbon, C

    1992-01-01

    Using an experimental endocarditis model, we studied the activity of daptomycin used alone or in combination with gentamicin against an Enterococcus faecium strain that was highly resistant to glycopeptides and susceptible to gentamicin. In vitro, the MIC of daptomycin was 1 micrograms/ml. In vivo, daptomycin appeared to be effective only when it was used in a high-dose regimen, i.e., 12 mg/kg of body weight every 8 h (-2.5 log10 CFU/g versus controls; P < 0.05), particularly when it was combined with gentamicin (-5.0 log10 CFU/g versus controls; P < 0.01). Since the distribution of daptomycin into cardiac vegetations, as evaluated by autoradiography, appeared to be homogeneous, the poor in vivo activity of daptomycin was considered to be related to its high degree of protein binding, as suggested by killing curves studies. Since the MIC of teicoplanin for the vancomycin-resistant E. faecium strain used in the study was only 64 micrograms/ml and since an in vitro synergy between teicoplanin at high dose and gentamicin was observed, a high-dose regimen of teicoplanin, i.e., 40 mg/kg every 12 h, was also assessed in vivo. This treatment provided marginal activity only when it was combined with gentamicin (-2.3 log10 CFU/g versus controls; P < 0.05). These results suggest that the levels of daptomycin or teicoplanin in serum required to cure experimental endocarditis caused by a highly glycopeptide-resistant strain of E. faecium would not be achievable in humans. Images PMID:1336339

  9. Neck/shoulder discomfort due to visually demanding experimental near work is influenced by previous neck pain, task duration, astigmatism, internal eye discomfort and accommodation

    PubMed Central

    Forsman, Mikael; Richter, Hans O.

    2017-01-01

    Visually demanding near work can cause eye discomfort, and eye and neck/shoulder discomfort during, e.g., computer work are associated. To investigate direct effects of experimental near work on eye and neck/shoulder discomfort, 33 individuals with chronic neck pain and 33 healthy control subjects performed a visual task four times using four different trial lenses (referred to as four different viewing conditions), and they rated eye and neck/shoulder discomfort at baseline and after each task. Since symptoms of eye discomfort may differ depending on the underlying cause, two categories were used; internal eye discomfort, such as ache and strain, that may be caused by accommodative or vergence stress; and external eye discomfort, such as burning and smarting, that may be caused by dry-eye disorders. The cumulative performance time (reflected in the temporal order of the tasks), astigmatism, accommodation response and concurrent symptoms of internal eye discomfort all aggravated neck/shoulder discomfort, but there was no significant effect of external eye discomfort. There was also an interaction effect between the temporal order and internal eye discomfort: participants with a greater mean increase in internal eye discomfort also developed more neck/shoulder discomfort with time. Since moderate musculoskeletal symptoms are a risk factor for more severe symptoms, it is important to ensure a good visual environment in occupations involving visually demanding near work. PMID:28832612

  10. Experimental evidence for the evolution of indirect genetic effects: changes in the interaction effect coefficient, psi (Psi), due to sexual selection.

    PubMed

    Chenoweth, Stephen F; Rundle, Howard D; Blows, Mark W

    2010-06-01

    Indirect genetics effects (IGEs)--when the genotype of one individual affects the phenotypic expression of a trait in another--may alter evolutionary trajectories beyond that predicted by standard quantitative genetic theory as a consequence of genotypic evolution of the social environment. For IGEs to occur, the trait of interest must respond to one or more indicator traits in interacting conspecifics. In quantitative genetic models of IGEs, these responses (reaction norms) are termed interaction effect coefficients and are represented by the parameter psi (Psi). The extent to which Psi exhibits genetic variation within a population, and may therefore itself evolve, is unknown. Using an experimental evolution approach, we provide evidence for a genetic basis to the phenotypic response caused by IGEs on sexual display traits in Drosophila serrata. We show that evolution of the response is affected by sexual but not natural selection when flies adapt to a novel environment. Our results indicate a further mechanism by which IGEs can alter evolutionary trajectories--the evolution of interaction effects themselves.

  11. Cefotaxime Acts Synergistically with Levofloxacin in Experimental Meningitis Due to Penicillin-Resistant Pneumococci and Prevents Selection of Levofloxacin-Resistant Mutants In Vitro

    PubMed Central

    Kühn, F.; Cottagnoud, M.; Acosta, F.; Flatz, L.; Entenza, J.; Cottagnoud, P.

    2003-01-01

    Cefotaxime, given in two doses (each 100 mg/kg of body weight), produced a good bactericidal activity (−0.47 Δlog10 CFU/ml · h) which was comparable to that of levofloxacin (−0.49 Δlog10 CFU/ml · h) against a penicillin-resistant pneumococcal strain WB4 in experimental meningitis. Cefotaxime combined with levofloxacin acted synergistically (−1.04 Δlog10 CFU/ml · h). Synergy between cefotaxime and levofloxacin was also demonstrated in vitro in time killing assays and with the checkerboard method for two penicillin-resistant strains (WB4 and KR4). Using in vitro cycling experiments, the addition of cefotaxime in sub-MIC concentrations (one-eighth of the MIC) drastically reduced levofloxacin-induced resistance in the same two strains (64-fold increase of the MIC of levofloxacin after 12 cycles versus 2-fold increase of the MIC of levofloxacin combined with cefotaxime). Mutations detected in the genes encoding topoisomerase IV (parC and parE) and gyrase (gyrA and gyrB) confirmed the levofloxacin-induced resistance in both strains. Addition of cefotaxime in low doses was able to suppress levofloxacin-induced resistance. PMID:12878509

  12. Unsteady loads due to propulsive lift configurations. Part C: Development of experimental techniques for investigation of unsteady pressures behind a cold model jet

    NASA Technical Reports Server (NTRS)

    Haviland, J. K.; Schroeder, J. C.

    1978-01-01

    As part of an overall study of the scaling laws for the fluctuating pressures induced on the wings and flaps of STOL aircraft by jet engine impingement, an experimental investigation was made of the near field fluctuating pressures behind a cold circular jet, both when it was free and when it was impinging on a flat plate. Miniature static pressure probes were developed for measurements in the free jet and on the flat plate which were connected by plastic tubing to 1/8 inch microphones and acted as pressure transducers. Using a digital correlator together with an FFT program on the CDC 6400 computer, spectral densities, relative amplitudes, phase lags, and coherences were also obtained for the signals from pairs of these probes, and were used to calibrate these probes directly against microphones. This system of instrumentation was employed to obtain single point rms and third octave surveys of the static pressures in the free jet and on the surface of the plate.

  13. Importance of penicillinase production for activity of penicillin alone or in combination with sulbactam in experimental endocarditis due to methicillin-resistant Staphylococcus aureus.

    PubMed Central

    Fantin, B; Pierre, J; Castéla-Papin, N; Saint-Julien, L; Drugeon, H; Farinotti, R; Carbon, C

    1996-01-01

    The activity of penicillin, alone and in combination with sulbactam, against a heterogeneously methicillin-resistant, penicillinase-producing clinical isolate of Staphylococcus aureus and its penicillinase-negative derivative was investigated in vitro and in a rabbit experimental endocarditis model. Penicillin was significantly more effective than vancomycin against the penicillinase-negative derivative in vivo (P < 0.001), and it sterilized 25% of the vegetations. The combination of penicillin and sulbactam exhibited an in vivo synergistic effect on the penicillinase-producing strain (P < 0.01) but did not produce any advantage over treatment with vancomycin, even when a high dose of sulbactam was used (100 mg/kg of body weight every 6 h). This combination was significantly less effective against the penicillinase-producing strain than was penicillin alone against the penicillinase-negative derivative (P < 0.03). In addition, the most resistant subpopulation of the surviving bacteria, which grew on agar containing 16 micrograms of methicillin per ml, was detected in 5 of 6 animals treated with penicillin and a high dose of sulbactam against the penicillinase-producing strain compared with only 1 of 12 animals treated with penicillin alone against the penicillinase-negative derivative (P < 0.01). We conclude that penicillin is highly effective against penicillinase-negative methicillin-resistant S. aureus and that penicillinase production, rather than methicillin resistance, appears to be the limiting factor for the activity of the penicillin-sulbactam combination against penicillinase-producing, methicillin-resistant S. aureus. PMID:8723470

  14. Therapeutic effects of ellagic acid on memory, hippocampus electrophysiology deficits, and elevated TNF-α level in brain due to experimental traumatic brain injury.

    PubMed

    Mashhadizadeh, Shahram; Farbood, Yaghoub; Dianat, Mahin; Khodadadi, Ali; Sarkaki, Alireza

    2017-04-01

    Cognitive defects such as learning and memory impairment are amongst the most repetitious sequelae after sever and moderate traumatic brain injury (TBI). It was suggested that ellagic acid (EA), an innate phenol product, display neuroprotective properties against oxidative and inflammatory damages after brain injury. The object of the current study was therapeutic properties of EA on blood-brain barrier (BBB) interruption and elevated content of TNF-α in brain tissue followed by neurologic aftereffects, cognitive and brain electrophysiology deficits as outcomes of diffuse TBI in rat. TBI was induced by a 200 g weight falling by a 2-m height through a free-falling tube onto the head of anesthetized rat. TBI rats treated immediately after trauma with EA (100 mg/kg, IP) once every 8 hr until 48 hr later. Neurologic outcomes, passive avoidance task (PAT), hippocampal long-term potentiation (LTP), BBB permeability and content of TNF-α in brain tissue were evaluated. TBI induced significant impairments in neurological score, BBB function, PAT and hippocampal LTP in TBI+Veh group in compare with Sham+Veh (P<0.001). EA treatment decreased neurologic severity score (NSS), restored increased BBB permeability, cognitive and hippocampal LTP abnormalities, and elevated brain content of TNF-α due to TBI significantly (P<0.001). Our findings propose that EA can restore NSS, cognitive and LTP deficits and prevent brain inflammation may by restore BBB permeability as well as lowering brain content of TNF-α following TBI.

  15. Pre- and post-experimental manipulation assessments confirm the increase in number of birds due to the addition of nest boxes

    PubMed Central

    Cuatianquiz Lima, Cecilia

    2016-01-01

    Secondary cavity nesting (SCN) birds breed in holes that they do not excavate themselves. This is possible where there are large trees whose size and age permit the digging of holes by primary excavators and only rarely happens in forest plantations, where we expected a deficit of both breeding holes and SCN species. We assessed whether the availability of tree cavities influenced the number of SCNs in two temperate forest types, and evaluated the change in number of SCNs after adding nest boxes. First, we counted all cavities within each of our 25-m radius sampling points in mature and young forest plots during 2009. We then added nest boxes at standardised locations during 2010 and 2011 and conducted fortnightly bird counts (January–October 2009–2011). In 2011 we added two extra plots of each forest type, where we also conducted bird counts. Prior to adding nest boxes, counts revealed more SCNs in mature than in young forest. Following the addition of nest boxes, the number of SCNs increased significantly in the points with nest boxes in both types of forest. Counts in 2011 confirmed the increase in number of birds due to the addition of nest boxes. Given the likely benefits associated with a richer bird community we propose that, as is routinely done in some countries, forest management programs preserve old tree stumps and add nest boxes to forest plantations in order to increase bird numbers and bird community diversity. PMID:26998410

  16. Acidification due to microbial dechlorination near a trichloroethene DNAPL is overcome with pH buffer or formate as electron donor: experimental demonstration in diffusion-cells.

    PubMed

    Philips, Jo; Maes, Nele; Springael, Dirk; Smolders, Erik

    2013-04-01

    Acidification due to microbial dechlorination of trichloroethene (TCE) can limit the bio-enhanced dissolution of TCE dense non-aqueous phase liquid (DNAPL). This study related the dissolution enhancement of a TCE DNAPL to the pH buffer capacity of the medium and the type of electron donor used. In batch systems, dechlorination was optimal at pH7.1-7.5, but was completely inhibited below pH6.2. In addition, dechlorination in batch systems led to a smaller pH decrease at an increasing pH buffer capacity or with the use of formate instead of lactate as electron donor. Subsequently, bio-enhanced TCE DNAPL dissolution was quantified in diffusion-cells with a 5.5 cm central sand layer, separating a TCE DNAPL layer from an aqueous top layer. Three different pH buffer capacities (2.9 mM-17.9 mM MOPS) and lactate or formate as electron donor were applied. In the lactate fed diffusion-cells, the DNAPL dissolution enhancement factor increased from 1.5 to 2.2 with an increase of the pH buffer capacity. In contrast, in the formate fed diffusion-cells, the DNAPL dissolution enhancement factor (2.4±0.3) was unaffected by the pH buffer capacity. Measurement of the pore water pH confirmed that the pH decreased less with an increased pH buffer capacity or with formate instead of lactate as electron donor. These results suggest that the significant impact of acidification on bio-enhanced DNAPL dissolution can be overcome by the amendment of a pH buffer or by applying a non acidifying electron donor like formate. Copyright © 2013 Elsevier B.V. All rights reserved.

  17. Kinematic background discrimination methods using a fully digital data acquisition system for TOFOR

    NASA Astrophysics Data System (ADS)

    Skiba, Mateusz; Ericsson, Göran; Hjalmarsson, Anders; Hellesen, Carl; Conroy, Sean; Andersson-Sundén, Erik; Eriksson, Jacob; JET Contributors

    2016-12-01

    A fully digital, prototype data acquisition system upgrade for the TOFOR neutron time-of-flight neutron spectrometer at the JET experimental fusion reactor in Culham, England, has been constructed. This upgrade, TOFu (Time-of-Flight upgrade), enables digitization of associated time and energy deposition information from the TOFOR scintillator detectors, facilitating discrimination of spectral background due to unrelated neutron events based on kinematic considerations. In this publication, a kinematic background discrimination method is presented using synthetic data and validated with experimental results. It is found that an improvement in signal-to-background ratio of 500% in certain spectral regions is possible with the new DAQ system.

  18. Background sources at PEP

    SciTech Connect

    Lynch, H.; Schwitters, R.F.; Toner, W.T.

    1988-01-01

    Important sources of background for PEP experiments are studied. Background particles originate from high-energy electrons and positrons which have been lost from stable orbits, ..gamma..-rays emitted by the primary beams through bremsstrahlung in the residual gas, and synchrotron radiation x-rays. The effect of these processes on the beam lifetime are calculated and estimates of background rates at the interaction region are given. Recommendations for the PEP design, aimed at minimizing background are presented. 7 figs., 4 tabs.

  19. The COMPTEL instrumental line background

    NASA Astrophysics Data System (ADS)

    Weidenspointner, G.; Varendorff, M.; Oberlack, U.; Morris, D.; Plüschke, S.; Diehl, R.; Kappadath, S. C.; McConnell, M.; Ryan, J.; Schönfelder, V.; Steinle, H.

    2001-03-01

    The instrumental line background of the Compton telescope COMPTEL onboard the Compton Gamma-Ray Observatory is due to the activation and/or decay of many isotopes. The major components of this background can be attributed to eight individual isotopes, namely 2D, 22Na, 24Na, 28Al, 40K, 52Mn, 57Ni, and 208Tl. The identification of instrumental lines with specific isotopes is based on the line energies as well as on the variation of the event rate with time, cosmic-ray intensity, and deposited radiation dose during passages through the South-Atlantic Anomaly. The characteristic variation of the event rate due to a specific isotope depends on its life-time, orbital parameters such as the altitude of the satellite above Earth, and the solar cycle. A detailed understanding of the background contributions from instrumental lines is crucial at MeV energies for measuring the cosmic diffuse gamma-ray background and for observing gamma -ray line emission in the interstellar medium or from supernovae and their remnants. Procedures to determine the event rate from each background isotope are described, and their average activity in spacecraft materials over the first seven years of the mission is estimated.

  20. Cosmic Microwave Background

    NASA Astrophysics Data System (ADS)

    Mather, John; Hinshaw, Gary; Page, Lyman

    The cosmic microwave background (CMB) radiation, the relic of the early phases of the expanding universe, is bright, full of information, and difficult to measure. Along with the recession of galaxies and the primordial nucleosynthesis, it is one of the strongest signs that the Hot Big Bang Model of the universe is correct. It is brightest around 2 mm wavelength, has a temperature of T_{cmb} = 2.72548 ± 0.00057 K, and has a blackbody spectrum within 50 parts per million. Its spatial fluctuations (around 0.01% on 1{}^{circ } scales) are possibly the relics of quantum mechanical processes in the early universe, modified by processes up to the decoupling at a redshift of about 1,000 (when the primordial plasma became mostly transparent). In the cold dark matter (DM) model with cosmic acceleration (Λ CDM), the fluctuation statistics are consistent with the model of inflation and can be used to determine other parameters within a few percent, including the Hubble constant, the Λ constant, the densities of baryonic and dark matter, and the primordial fluctuation amplitude and power spectrum slope. In addition, the polarization of the fluctuations reveals the epoch of reionization at a redshift approximately twice that determined from the Gunn-Peterson trough due to optically thick Lyman α absorption in QSO spectra. It is of historic importance, and a testament to the unity of theory and experiment, that we now have a standard model of cosmology that is consistent with all of the observations.Current observational challenges include (1) improvement of the spectrum distortion measurements, especially at long wavelengths, where the measured background is unexpectedly bright; (2) the search for the B-mode polarization (the divergence-free part of the polarization map), arising from propagating gravitational waves; and (3) the extension of fluctuation measurements to smaller angular scales. Much more precise spectrum observations near 2 mm are likely and would test some

  1. Gamma-ray Background Spectrum and Annihilation Rate in the Baryon-symmetric Big-bang Cosmology

    NASA Technical Reports Server (NTRS)

    Puget, J. L.

    1973-01-01

    An attempt was made to acquire experimental information on the problem of baryon symmetry on a large cosmological scale by observing the annihilation products. Data cover absorption cross sections and background radiation due to other sources for the two main products of annihilation, gamma rays and neutrinos. Test results show that the best direct experimental test for the presence of large scale antimatter lies in the gamma ray background spectrum between 1 and 70 MeV.

  2. Gamma-ray Background Spectrum and Annihilation Rate in the Baryon-symmetric Big-bang Cosmology

    NASA Technical Reports Server (NTRS)

    Puget, J. L.

    1973-01-01

    An attempt was made to acquire experimental information on the problem of baryon symmetry on a large cosmological scale by observing the annihilation products. Data cover absorption cross sections and background radiation due to other sources for the two main products of annihilation, gamma rays and neutrinos. Test results show that the best direct experimental test for the presence of large scale antimatter lies in the gamma ray background spectrum between 1 and 70 MeV.

  3. Electron paramagnetic resonance line shifts and line shape changes due to heisenberg spin exchange and dipole-dipole interactions of nitroxide free radicals in liquids 8. Further experimental and theoretical efforts to separate the effects of the two interactions.

    PubMed

    Peric, Mirna; Bales, Barney L; Peric, Miroslav

    2012-03-22

    The work in part 6 of this series (J. Phys. Chem. A 2009, 113, 4930), addressing the task of separating the effects of Heisenberg spin exchange (HSE) and dipole-dipole interactions (DD) on electron paramagnetic resonance (EPR) spectra of nitroxide spin probes in solution, is extended experimentally and theoretically. Comprehensive measurements of perdeuterated 2,2,6,6-tetramethyl-4-oxopiperidine-1-oxyl (pDT) in squalane, a viscous alkane, paying special attention to lower temperatures and lower concentrations, were carried out in an attempt to focus on DD, the lesser understood of the two interactions. Theoretically, the analysis has been extended to include the recent comprehensive treatment by Salikhov (Appl. Magn. Reson. 2010, 38, 237). In dilute solutions, both interactions (1) introduce a dispersion component, (2) broaden the lines, and (3) shift the lines. DD introduces a dispersion component proportional to the concentration and of opposite sign to that of HSE. Equations relating the EPR spectral parameters to the rate constants due to HSE and DD have been derived. By employing nonlinear least-squares fitting of theoretical spectra to a simple analytical function and the proposed equations, the contributions of the two interactions to items 1-3 may be quantified and compared with the same parameters obtained by fitting experimental spectra. This comparison supports the theory in its broad predictions; however, at low temperatures, the DD contribution to the experimental dispersion amplitude does not increase linearly with concentration. We are unable to deduce whether this discrepancy is due to inadequate analysis of the experimental data or an incomplete theory. A new key aspect of the more comprehensive theory is that there is enough information in the experimental spectra to find items 1-3 due to both interactions; however, in principle, appeal must be made to a model of molecular diffusion to separate the two. The permanent diffusion model is used to

  4. EPR Line Shifts and Line Shape Changes Due to Heisenberg Spin Exchange and Dipole-Dipole Interactions of Nitroxide Free Radicals in Liquids: 8. Further Experimental and Theoretical Efforts to Separate the Effects of the Two Interactions

    PubMed Central

    Peric, Mirna; Bales, Barney L; Peric, Miroslav

    2012-01-01

    The work in Part 6 of this series (J. Phys. Chem. A 2009, 113, 4930), addressing the task of separating the effects of Heisenberg spin exchange (HSE) and dipole-dipole (DD) interactions on EPR spectra of nitroxide spin probes in solution, is extended experimentally and theoretically. Comprehensive measurements of perdeuterated 2,2,6,6-tetramethyl-4-oxopiperidine-1-oxyl (pDT) in squalane, a viscous alkane, paying special attention to lower temperatures and lower concentrations were carried out in an attempt to focus on DD, the lesser understood of the two interactions. Theoretically, the analysis has been extended to include the recent comprehensive treatment by Salikhov (Appl. Magn. Reson. 2010, 38, 237). In dilute solutions, both interactions (1) introduce a dispersion component, (2) broaden the lines, and (3) shift the lines. DD introduces a dispersion component proportional to the concentration and of opposite sign to that of HSE. Equations relating the EPR spectral parameters to the rate constants due HSE and DD have been derived. By employing non-linear least-squares fitting of theoretical spectra to a simple analytical function and the proposed equations, the contributions of the two interactions to items (1)–(3) may be quantified and compared with the same parameters obtained by fitting experimental spectra. This comparison supports the theory in its broad predictions, however, at low temperatures, the DD contribution to the experimental dispersion amplitude does not increase linearly with concentration. We are unable to deduce if this discrepancy is due to inadequate analysis of the experimental data or an incomplete theory. A key new aspect of the more comprehensive theory is that there is enough information in the experimental spectra to find items (1)–(3) due to both interactions; however, in principle, appeal must be made to a model of molecular diffusion to separate the two. The permanent diffusion model is used to illustrate the separation in this

  5. The Cosmic Background Explorer.

    ERIC Educational Resources Information Center

    Gulkis, Samuel; And Others

    1990-01-01

    Outlines the Cosmic Background Explorer (COBE) mission to measure celestial radiation. Describes the instruments used and experiments involving differential microwave radiometers, and a far infrared absolute spectrophotometer. (YP)

  6. The Cosmic Background Explorer.

    ERIC Educational Resources Information Center

    Gulkis, Samuel; And Others

    1990-01-01

    Outlines the Cosmic Background Explorer (COBE) mission to measure celestial radiation. Describes the instruments used and experiments involving differential microwave radiometers, and a far infrared absolute spectrophotometer. (YP)

  7. Background simulations and shielding calculations

    NASA Astrophysics Data System (ADS)

    Kudryavtsev, Vitaly A.

    2011-04-01

    Key improvements in the sensitivity of the underground particle astrophysics experiments can only be achieved if the radiation causing background events in detectors is well understood and proper measures are taken to suppress it. The background radiation arising from radioactivity and cosmic-ray muons is discussed here together with the methods of its suppression. Different shielding designs are considered to attenuate gamma-rays and neutrons coming from radioactivity in rock and lab walls. Purity of materials used in detector construction is analysed and the background event rates due to the presence of radioactive isotopes in detector components are discussed. Event rates in detectors caused by muon-induced neutrons with and without active veto systems are presented leading to the requirements for the depth of an underground laboratory and the efficiency of the veto system.

  8. The Athena Background

    NASA Astrophysics Data System (ADS)

    Piro, Luigi; Lotti, Simone; Macculi, Claudio; Molendi, Silvano; Eraerds, Tanja; Laurent, Philippe

    2015-09-01

    Estimating, reducing and controlling the residual particle background is fundamental for achieving the objectives of several science topics of Athena, in particular those connected with background dominated observations of faint and/or diffuse sources. This requires assessing the particle environment in L2, propagating the various particle components throughout the mirror, spacecraft, and instruments via proper modelling and simulations of various physical processes, implementing design and h/w measures at instrument and mission level to reduce the un-rejected background and identifying proper calibration methods to control the background variations. Likewise, an adequate knowledge of the XRB, made of components that may vary spatially or temporally, is required as well. Here we will review the present status of the background knowledge, and summarize the activities on-going within Athena at various levels.

  9. Correlators in nontrivial backgrounds

    SciTech Connect

    Mello Koch, Robert de; Ives, Norman; Stephanou, Michael

    2009-01-15

    Operators in N=4 super Yang-Mills theory with an R-charge of O(N{sup 2}) are dual to backgrounds which are asymtotically AdS{sub 5}xS{sup 5}. In this article we develop efficient techniques that allow the computation of correlation functions in these backgrounds. We find that (i) contractions between fields in the string words and fields in the operator creating the background are the field theory accounting of the new geometry, (ii) correlation functions of probes in these backgrounds are given by the free field theory contractions but with rescaled propagators and (iii) in these backgrounds there are no open string excitations with their special end point interactions; we have only closed string excitations.

  10. Background removal procedure for rapid scan EPR.

    PubMed

    Tseitlin, Mark; Czechowski, Tomasz; Quine, Richard W; Eaton, Sandra S; Eaton, Gareth R

    2009-01-01

    In rapid scan EPR the changing magnetic field creates a background signal with components at the scan frequency and its harmonics. The amplitude of the background signal increases with scan width and is more significant for weak EPR signals such as are obtained in the presence of magnetic field gradients. A procedure for distinguishing this background from the EPR signal is proposed, mathematically described, and tested for various experimental conditions.

  11. The cosmic neutrino background

    NASA Technical Reports Server (NTRS)

    Dar, Arnon

    1991-01-01

    The cosmic neutrino background is expected to consist of relic neutrinos from the big bang, of neutrinos produced during nuclear burning in stars, of neutrinos released by gravitational stellar collapse, and of neutrinos produced by cosmic ray interactions with matter and radiation in the interstellar and intergalactic medium. Formation of baryonic dark matter in the early universe, matter-antimatter annihilation in a baryonic symmetric universe, and dark matter annihilation could have also contributed significantly to the cosmic neutrino background. The purpose of this paper is to review the properties of these cosmic neutrino backgrounds, the indirect evidence for their existence, and the prospects for their detection.

  12. The GLAST Background Model

    SciTech Connect

    Ormes, J. F.; Atwood, W.; Burnett, T.; Grove, E.; Longo, F.; McEnery, J.; Ritz, S.; Mizuno, T.

    2007-07-12

    In order to estimate the ability of the GLAST/LAT to reject unwanted background of charged particles, optimize the on-board processing, size the required telemetry and optimize the GLAST orbit, we developed a detailed model of the background particles that would affect the LAT. In addition to the well-known components of the cosmic radiation, we included splash and reentrant components of protons, electrons (e+ and e-) from 10 MeV and beyond as well as the albedo gamma rays produced by cosmic ray interactions with the atmosphere. We made estimates of the irreducible background components produced by positrons and hadrons interacting in the multilayered micrometeorite shield and spacecraft surrounding the LAT and note that because the orbital debris has increased, the shielding required and hence the background are larger than were present in EGRET. Improvements to the model are currently being made to include the east-west effect.

  13. The GLAST Background Model

    SciTech Connect

    Ormes, J.F.; Atwood, W.; Burnett, T.; Grove, E.; Longo, F.; McEnery, J.; Mizuno, T.; Ritz, S.; /NASA, Goddard

    2007-10-17

    In order to estimate the ability of the GLAST/LAT to reject unwanted background of charged particles, optimize the on-board processing, size the required telemetry and optimize the GLAST orbit, we developed a detailed model of the background particles that would affect the LAT. In addition to the well-known components of the cosmic radiation, we included splash and reentrant components of protons, electrons (e+ and e-) from 10 MeV and beyond as well as the albedo gamma rays produced by cosmic ray interactions with the atmosphere. We made estimates of the irreducible background components produced by positrons and hadrons interacting in the multilayered micrometeorite shield and spacecraft surrounding the LAT and note that because the orbital debris has increased, the shielding required and hence the background are larger than were present in EGRET. Improvements to the model are currently being made to include the east-west effect.

  14. Notification: Background Investigation Services

    EPA Pesticide Factsheets

    Project #OA-FY15-0029, February 26, 2015. The Office of Inspector General (OIG) for the U.S. Environmental Protection Agency (EPA) plans to begin field work for our audit of background investigation services.

  15. Bayesian background estimation

    NASA Astrophysics Data System (ADS)

    Fischer, R.; Dose, V.; Hanson, K. M.; von der Linden, W.

    2001-05-01

    The ubiquitous problem of estimating the background of a measured spectrum is solved with Bayesian probability theory. A mixture model is used to capture the defining characteristics of the problem, namely that the background is smoother than the signal. The smoothness property is quantified in terms of a cubic spline basis where a variable degree of smoothness is attained by allowing the number of knots and the knot positions to be adaptively chosen on the basis of the data. The fully Bayesian approach taken provides a natural way to handle knot adaptivity, allows uncertainties in the background to be estimated and data points to be classified in groups containing only background and groups with additional signal contribution. Our technique is demonstrated on a PIXE spectrum from a geological sample and an Auger spectrum from an 10 monolayer iron film on tungsten.

  16. Background Studies for the pn-CCD Detector of CAST

    SciTech Connect

    Rodriguez, A.; Beltran, B.; Cebrian, S.; Gomez, H.; Irastorza, I. G.; Luzon, G.; Morales, J.; Ruz, J.; Villar, J. A.; Hartmann, R.; Kotthaus, R.; Klose, C.; Kuster, M.; Strueder, L.

    2007-03-28

    The CERN Axion Solar Telescope (CAST) experiment searches for axions from the Sun converted into photons with energies up to around 10 keV via the inverse Primakoff effect in the high magnetic field of a superconducting Large Hadron Collider (LHC) prototype magnet. A backside illuminated pn-CCD detector in conjunction with an X-ray mirror optics is one of the three detectors used in CAST to register the expected photon signal. Since this signal is very rare a detailed study of the detector background has been undertaken with the aim to understand and further reduce the background level of the detector. The analysis is based on measured data taken during the data taking period of 2003 and 2004 of CAST and on Monte Carlo simulations of background with different origin. The background study performed for this detector show that the level of background (8.00{+-}0.07)x10-5 counts cm-2 s-1 keV-1 between 1 and 7 keV is dominated by the external gamma background due to natural activities at the experimental site, while radioactive impurities in the detector itself and cosmic neutrons contribute with a smaller fraction.

  17. SPI instrumental background characteristics

    NASA Astrophysics Data System (ADS)

    Jean, P.; Vedrenne, G.; Roques, J. P.; Schönfelder, V.; Teegarden, B. J.; von Kienlin, A.; Knödlseder, J.; Wunderer, C.; Skinner, G. K.; Weidenspointner, G.; Attié, D.; Boggs, S.; Caraveo, P.; Cordier, B.; Diehl, R.; Gros, M.; Leleux, P.; Lichti, G. G.; Kalemci, E.; Kiener, J.; Lonjou, V.; Mandrou, P.; Paul, Ph.; Schanne, S.; von Ballmoos, P.

    2003-11-01

    In its space environment the INTEGRAL observatory is subject to an intense irradiation by energetic cosmic-ray particles that leads, via nuclear interactions with the telescope and spacecraft materials, to an important background of false events. In this paper we present the characteristics of the instrumental background that is observed in the spectrometer SPI (SPectrometer of INTEGRAL). We explain the tuning that has been performed on the parameters of the anticoincidence system in order to optimise the telescope sensitivity over the full energy range. Temporal variations of the instrumental background are discussed and methods are proposed that allow for their modelling in first order. Based on observations with INTEGRAL, an ESA project with instruments and science data centre funded by ESA member states (especially the PI countries: Denmark, France, Germany, Italy, Switzerland, Spain), Czech Republic and Poland, and with the participation of Russia and the USA.

  18. The Cosmic Background Explorer

    NASA Technical Reports Server (NTRS)

    Gulkis, Samuel; Lubin, Philip M.; Meyer, Stephan S.; Silverberg, Robert F.

    1990-01-01

    The Cosmic Background Explorer (CBE), NASA's cosmological satellite which will observe a radiative relic of the big bang, is discussed. The major questions connected to the big bang theory which may be clarified using the CBE are reviewed. The satellite instruments and experiments are described, including the Differential Microwave Radiometer, which measures the difference between microwave radiation emitted from two points on the sky, the Far-Infrared Absolute Spectrophotometer, which compares the spectrum of radiation from the sky at wavelengths from 100 microns to one cm with that from an internal blackbody, and the Diffuse Infrared Background Experiment, which searches for the radiation from the earliest generation of stars.

  19. Cosmic Tachyon Background Radiation

    NASA Astrophysics Data System (ADS)

    Tomaschitz, Roman

    The equilibrium statistical mechanics of a background radiation of superluminal particles is investigated, based on a vectorial wave equation for tachyons of the Proca type. The partition function, the spectral energy density, and the various thermodynamic variables of an ideal Bose gas of tachyons in an open Robertson-Walker cosmology are derived. The negative mass square in the wave equation changes the frequency scaling in the Rayleigh-Jeans law, and there are also significant changes in the low temperature regime as compared to the microwave background, in particular in the caloric and thermal equations of state.

  20. Pattern-based video coding with dynamic background modeling

    NASA Astrophysics Data System (ADS)

    Paul, Manoranjan; Lin, Weisi; Lau, Chiew Tong; Lee, Bu-Sung

    2013-12-01

    The existing video coding standard H.264 could not provide expected rate-distortion (RD) performance for macroblocks (MBs) with both moving objects and static background and the MBs with uncovered background (previously occluded). The pattern-based video coding (PVC) technique partially addresses the first problem by separating and encoding moving area and skipping background area at block level using binary pattern templates. However, the existing PVC schemes could not outperform the H.264 with significant margin at high bit rates due to the least number of MBs classified using the pattern mode. Moreover, both H.264 and the PVC scheme could not provide the expected RD performance for the uncovered background areas due to the unavailability of the reference areas in the existing approaches. In this paper, we propose a new PVC technique which will use the most common frame in a scene (McFIS) as a reference frame to overcome the problems. Apart from the use of McFIS as a reference frame, we also introduce a content-dependent pattern generation strategy for better RD performance. The experimental results confirm the superiority of the proposed schemes in comparison with the existing PVC and the McFIS-based methods by achieving significant image quality gain at a wide range of bit rates.

  1. Berkeley Low Background Facility

    NASA Astrophysics Data System (ADS)

    Thomas, K. J.; Smith, A. R.; Poon, A. W. P.; Chan, Y. D.; Norman, E. B.; Lesko, K. T.

    2015-08-01

    The Berkeley Low Background Facility (BLBF) at Lawrence Berkeley National Laboratory (LBNL) in Berkeley, California provides low background gamma spectroscopy services to a wide array of experiments and projects. The analysis of samples takes place within two unique facilities; locally within a carefully-constructed, low background laboratory on the surface at LBNL and at the Sanford Underground Research Facility (SURF) in Lead, SD. These facilities provide a variety of gamma spectroscopy services to low background experiments primarily in the form of passive material screening for primordial radioisotopes (U, Th, K) or common cosmogenic/anthropogenic products; active screening via neutron activation analysis for U,Th, and K as well as a variety of stable isotopes; and neutron flux/beam characterization measurements through the use of monitors. A general overview of the facilities, services, and sensitivities will be presented. Recent activities and upgrades will also be described including an overview of the recently installed counting system at SURF (recently relocated from Oroville, CA in 2014), the installation of a second underground counting station at SURF in 2015, and future plans. The BLBF is open to any users for counting services or collaboration on a wide variety of experiments and projects.

  2. Building Background Knowledge

    ERIC Educational Resources Information Center

    Fisher, Douglas; Ross, Donna; Grant, Maria

    2010-01-01

    Too often, students enter our classrooms with insufficient knowledge of physical science. As a result, they have a difficult time understanding content in texts, lectures, and laboratory activities. This lack of background knowledge can have an impact on their ability to ask questions and wonder--both key components of inquiry. In this article,…

  3. Berkeley Low Background Facility

    SciTech Connect

    Thomas, K. J.; Norman, E. B.; Smith, A. R.; Poon, A. W. P.; Chan, Y. D.; Lesko, K. T.

    2015-08-17

    The Berkeley Low Background Facility (BLBF) at Lawrence Berkeley National Laboratory (LBNL) in Berkeley, California provides low background gamma spectroscopy services to a wide array of experiments and projects. The analysis of samples takes place within two unique facilities; locally within a carefully-constructed, low background laboratory on the surface at LBNL and at the Sanford Underground Research Facility (SURF) in Lead, SD. These facilities provide a variety of gamma spectroscopy services to low background experiments primarily in the form of passive material screening for primordial radioisotopes (U, Th, K) or common cosmogenic/anthropogenic products; active screening via neutron activation analysis for U,Th, and K as well as a variety of stable isotopes; and neutron flux/beam characterization measurements through the use of monitors. A general overview of the facilities, services, and sensitivities will be presented. Recent activities and upgrades will also be described including an overview of the recently installed counting system at SURF (recently relocated from Oroville, CA in 2014), the installation of a second underground counting station at SURF in 2015, and future plans. The BLBF is open to any users for counting services or collaboration on a wide variety of experiments and projects.

  4. Nonthermal cosmic neutrino background

    NASA Astrophysics Data System (ADS)

    Chen, Mu-Chun; Ratz, Michael; Trautner, Andreas

    2015-12-01

    We point out that, for Dirac neutrinos, in addition to the standard thermal cosmic neutrino background (C ν B ), there could also exist a nonthermal neutrino background with comparable number density. As the right-handed components are essentially decoupled from the thermal bath of standard model particles, relic neutrinos with a nonthermal distribution may exist until today. The relic density of the nonthermal (nt) background can be constrained by the usual observational bounds on the effective number of massless degrees of freedom Neff and can be as large as nν nt≲0.5 nγ. In particular, Neff can be larger than 3.046 in the absence of any exotic states. Nonthermal relic neutrinos constitute an irreducible contribution to the detection of the C ν B and, hence, may be discovered by future experiments such as PTOLEMY. We also present a scenario of chaotic inflation in which a nonthermal background can naturally be generated by inflationary preheating. The nonthermal relic neutrinos, thus, may constitute a novel window into the very early Universe.

  5. Foregrounding the Background.

    ERIC Educational Resources Information Center

    Robbins, Bruce

    1998-01-01

    Argues that when introductory activities to the classics begin with background information, it can upstage or confine the life of the story, and shows little faith in the students as readers or in the literature itself. Suggests sometimes letting the literature begin, and then helping students make sense of it. Discusses examples from "To Kill a…

  6. China: Background Notes Series.

    ERIC Educational Resources Information Center

    Reams, Joanne Reppert

    Concise background information on the People's Republic of China is provided. The publication begins with a profile of the country, outlining the people, geography, economy, and membership in international organizations. The bulk of the document then discusses in more detail China's people, geography, history, government, education, economy, and…

  7. Building Background Knowledge

    ERIC Educational Resources Information Center

    Fisher, Douglas; Ross, Donna; Grant, Maria

    2010-01-01

    Too often, students enter our classrooms with insufficient knowledge of physical science. As a result, they have a difficult time understanding content in texts, lectures, and laboratory activities. This lack of background knowledge can have an impact on their ability to ask questions and wonder--both key components of inquiry. In this article,…

  8. Atrazine - Background and Updates

    EPA Pesticide Factsheets

    Atrazine is a widely used herbicide that can be applied before and after planting to control broadleaf and grassy weeds. Atrazine is part of the triazine chemical class which includes simazine and propazine due to their common mechanism of toxicity.

  9. Some background about satellites

    NASA Technical Reports Server (NTRS)

    Burns, Joseph A.

    1986-01-01

    Four tables of planetary and satellite data are presented which list satellite discoveries, planetary parameters, satellite orbits, and satellite physical properties respectively. A scheme for classifying the satellites is provided and it is noted that most known moons fall into three general classes: regular satellites, collisional shards, and irregular satellites. Satellite processes are outlined with attention given to origins, dynamical and thermal evolution, surface processes, and composition and cratering. Background material is provided for each family of satellites.

  10. Executive Summary: Background

    NASA Technical Reports Server (NTRS)

    1983-01-01

    Background information on, and the objectives of, the NASA Global Biology Research Program are given. The following issues were addressed: (1) geographic distribution of wetland parameters, (2) the processes of wetland material fluxes, and (3) the relation of local fluxes with global processes. Wetland inventorying and categorizing, gas-phase exchanges with the atmosphere, material exchange with the aquatic environment, and material storage in wetland sediments were identified as topics requiring further research.

  11. Ultraviolet Background Radiation (Preprint)

    DTIC Science & Technology

    1991-03-01

    itself. A comprehensive summary of the observations is provided by Labov , Martin & Bowyer (59), and reviews of the relevant astronomy, which is...with William G. Fastie’s Apollo 17 experiment, our spurious background will translate into 0.2 units, which is negligible. If, on the other hand...grateful to all of my collaborators and supporters over the years, particularly Paul D. Feldman and William G. Fastie. Partial support for this

  12. Stochastic gravitational wave background from light cosmic strings

    SciTech Connect

    DePies, Matthew R.; Hogan, Craig J.

    2007-06-15

    Spectra of the stochastic gravitational wave backgrounds from cosmic strings are calculated and compared with present and future experimental limits. Motivated by theoretical expectations of light cosmic strings in superstring cosmology, improvements in experimental sensitivity, and recent demonstrations of large, stable loop formation from a primordial network, this study explores a new range of string parameters with masses lighter than previously investigated. A standard 'one-scale' model for string loop formation is assumed. Background spectra are calculated numerically for dimensionless string tensions G{mu}/c{sup 2} between 10{sup -7} and 10{sup -18}, and initial loop sizes as a fraction of the Hubble radius {alpha} from 0.1 to 10{sup -6}. The spectra show a low frequency power-law tail, a broad spectral peak due to loops decaying at the present epoch (including frequencies higher than their fundamental mode, and radiation associated with cusps), and a flat (constant energy density) spectrum at high frequencies due to radiation from loops that decayed during the radiation-dominated era. The string spectrum is distinctive and unlike any other known source. The peak of the spectrum for light strings appears at high frequencies, significantly affecting predicted signals. The spectra of the cosmic string backgrounds are compared with current millisecond pulsar limits and Laser Interferometer Space Antenna (LISA) sensitivity curves. For models with large stable loops ({alpha}=0.1), current pulsar-timing limits exclude G{mu}/c{sup 2}>10{sup -9}, a much tighter limit on string tension than achievable with other techniques, and within the range of current models based on brane inflation. LISA may detect a background from strings as light as G{mu}/c{sup 2}{approx_equal}10{sup -16}, corresponding to field theory strings formed at roughly 10{sup 11} GeV.

  13. Cosmic Background Radiation

    NASA Astrophysics Data System (ADS)

    Sidharth, B. G.; Valluri, S. R.

    2015-08-01

    It is shown that a collection of photons with nearly the same frequency exhibits a "condensation" type of phenomenon corresponding to a peak intensity. The observed cosmic background radiation can be explained from this standpoint. We have obtained analogous results by extremization of the occupation number for photons with the use of the Lambert W function. Some of the interesting applications of this function are briefly discussed in the context of graphene which exhibits an interesting two dimensional structure with several characteristic properties and diverse practical applications.

  14. Backgrounds Data Center

    NASA Astrophysics Data System (ADS)

    Snyder, William A.; Gursky, Herbert; Heckathorn, Harry M.; Lucke, Bob L.; Dorland, Bryan N.; Kessel, R. A.; Berg, S. L.; Dombrowski, E. G.

    1994-09-01

    The Backgrounds Data Center (BDC) is the designated archive for backgrounds data collected by Ballistic Missile Defense Organization (BMDO) programs, some of which include ultraviolet sensors. Currently, the BDC holds ultraviolet data from the IBSS, UVPI, UVLIM, and FUVCAM sensors. The BDC will also be the prime archive for Midcourse Space Experiment (MSX) data and is prepared to negotiate with program managers to handle other datasets. The purpose of the BDC is to make data accessible to users and to assist them in analyzing it. The BDC maintains the Science Catalog Information Exchange System (SCIES) allowing remote users to log in, read or post notices about current programs, search the catalogs for datasets of interest, and submit orders for data. On-site facilities are also available for the analysis of data, and consist of VMS and UNIX workstations with access to software analysis packages such as IDL, IRAF, and Khoros. Either on-site or remotely, users can employ the BDC-developed graphical user interface called the Visual Interface for Space and Terrestrial Analysis (VISTA) to generate catalog queries and to display and analyze data. SCIES and VISTA permit nearly complete access to BDC services and capabilities without the need to be physically present at the data center.

  15. The Backgrounds Data Center

    NASA Technical Reports Server (NTRS)

    Snyder, W. A.; Gursky, H.; Heckathorn, H. M.; Lucke, R. L.; Berg, S. L.; Dombrowski, E. G.; Kessel, R. A.

    1993-01-01

    The Strategic Defense Initiative Organization has created data centers for midcourse, plumes, and backgrounds phenomenologies. The Backgrounds Data Center (BDC) has been designated as the prime archive for data collected by SDIO programs. The BDC maintains a Summary Catalog that contains 'metadata,' that is, information about data, such as when the data were obtained, what the spectral range of the data is, and what region of the Earth or sky was observed. Queries to this catalog result in a listing of all data sets (from all experiments in the Summary Catalog) that satisfy the specified criteria. Thus, the user can identify different experiments that made similar observations and order them from the BDC for analysis. On-site users can use the Science Analysis Facility (SAFE for this purpose. For some programs, the BDC maintains a Program Catalog, which can classify data in as many ways as desired (rather than just by position, time, and spectral range as in the Summary Catalog). For example, data sets could be tagged with such diverse parameters as solar illumination angle, signal level, or the value of a particular spectral ratio, as long as these quantities can be read from the digital record or calculated from it by the ingest program. All unclassified catalogs and unclassified data will be remotely accessible.

  16. Extragalactic Backgrounds after Planck

    NASA Astrophysics Data System (ADS)

    Dore, Olivier

    Among the potentially most important results of cosmology in the last decade is the realization that the star formation rate at redshifts greater than 1 is higher than at present by about an order of magnitude, and that half of the energy produced since the surface of last scattering has been absorbed and reemitted by dust. Most of the light produced by stars at high redshifts thus reaches us in the far infrared. This radiation is referred to as the cosmic infrared background (CIB) and is emitted primarily by dusty, star-forming galaxies at redshift z=1-4. Embedded in far infrared emission of the CIB is the history of star formation, dust production, and the growth of large scale structures. Our research project aims at shedding new light on several extragalactic backgrounds investigated by NASA surveys, in light of recent observational progresses in mapping the CIB. Most lately, two new missions, Planck and Herschel, released ground-breaking measurements of the CIB. These measurements are an order of magnitude deeper and wider than previous ones, and they are literally revolutionizing the field. Our understanding of these data is now advanced enough for us to leverage our measurement of the CIB in Planck and Herschel, in order to extract new scientific insights from past missions. We propose to combine Planck and Herschel public data with archival data from WISE, GALEX, Chandra and Fermi. Not only original, the impact of our research project should be immediate. Using the CIB as a full sky, bright, high redshift reference extragalactic background, we will exploit the underlying physical connection among these various cosmological datasets. We expect new insights about the CIB, but also about the multiple extragalactic backgrounds probed in combination with it. In particular, we will investigate the cosmic star formation history at a period where it peaks, and because the clustering of matter is driven by dark matter, the measurement of the CIB clustering also

  17. Video coding with dynamic background

    NASA Astrophysics Data System (ADS)

    Paul, Manoranjan; Lin, Weisi; Lau, Chiew Tong; Lee, Bu-Sung

    2013-12-01

    Motion estimation (ME) and motion compensation (MC) using variable block size, sub-pixel search, and multiple reference frames (MRFs) are the major reasons for improved coding performance of the H.264 video coding standard over other contemporary coding standards. The concept of MRFs is suitable for repetitive motion, uncovered background, non-integer pixel displacement, lighting change, etc. The requirement of index codes of the reference frames, computational time in ME & MC, and memory buffer for coded frames limits the number of reference frames used in practical applications. In typical video sequences, the previous frame is used as a reference frame with 68-92% of cases. In this article, we propose a new video coding method using a reference frame [i.e., the most common frame in scene (McFIS)] generated by dynamic background modeling. McFIS is more effective in terms of rate-distortion and computational time performance compared to the MRFs techniques. It has also inherent capability of scene change detection (SCD) for adaptive group of picture (GOP) size determination. As a result, we integrate SCD (for GOP determination) with reference frame generation. The experimental results show that the proposed coding scheme outperforms the H.264 video coding with five reference frames and the two relevant state-of-the-art algorithms by 0.5-2.0 dB with less computational time.

  18. Background processes in the KATRIN main spectrometer

    NASA Astrophysics Data System (ADS)

    Fraenkle, F. M.; KATRIN collaboration

    2017-09-01

    The KArlsruhe TRItium Neutrino (KATRIN) experiment is a large-scale experiment which aims for the model-independent determination of the effective mass of electron anti-neutrinos with a sensitivity of 200 meV/c2. It investigates the kinematics of electrons from tritium β-decay close to the endpoint of the energy spectrum. Low statistics at the endpoint requires an equally low background rate below 0.01 counts per second. The measurement setup consists of a high luminosity windowless gaseous molecular tritium source (WGTS), a differential and cryogenic pumped electron transport and tritium retention section, a tandem spectrometer section (pre-spectrometer and main spectrometer) for energy analysis, followed by a detector system for counting transmitted beta decay electrons. The background characteristics of the KATRIN main spectrometer were investigated in detail during two commissioning measurement phases. Of particular interest were backgrounds due to the decay of radon in the volume of the spectrometer, cosmic-muon-induced backgrounds, backgrounds due to natural radioactivity and Penning-discharge-related backgrounds. This proceeding will present results of the commissioning measurements and focuses on different background processes and their contribution to the overall background of the KATRIN experiment.

  19. Cosmic microwave background theory.

    PubMed

    Bond, J R

    1998-01-06

    A long-standing goal of theorists has been to constrain cosmological parameters that define the structure formation theory from cosmic microwave background (CMB) anisotropy experiments and large-scale structure (LSS) observations. The status and future promise of this enterprise is described. Current band-powers in -space are consistent with a DeltaT flat in frequency and broadly follow inflation-based expectations. That the levels are approximately (10(-5))2 provides strong support for the gravitational instability theory, while the Far Infrared Absolute Spectrophotometer (FIRAS) constraints on energy injection rule out cosmic explosions as a dominant source of LSS. Band-powers at 100 suggest that the universe could not have re-ionized too early. To get the LSS of Cosmic Background Explorer (COBE)-normalized fluctuations right provides encouraging support that the initial fluctuation spectrum was not far off the scale invariant form that inflation models prefer: e.g., for tilted Lambda cold dark matter sequences of fixed 13-Gyr age (with the Hubble constant H0 marginalized), ns = 1.17 +/- 0.3 for Differential Microwave Radiometer (DMR) only; 1.15 +/- 0.08 for DMR plus the SK95 experiment; 1.00 +/- 0.04 for DMR plus all smaller angle experiments; 1.00 +/- 0.05 when LSS constraints are included as well. The CMB alone currently gives weak constraints on Lambda and moderate constraints on Omegatot, but theoretical forecasts of future long duration balloon and satellite experiments are shown which predict percent-level accuracy among a large fraction of the 10+ parameters characterizing the cosmic structure formation theory, at least if it is an inflation variant.

  20. The Sunyaev-Zeldovich background

    NASA Astrophysics Data System (ADS)

    Holder, Gilbert P.; McCarthy, Ian G.; Babul, A.

    2007-12-01

    The cosmic background due to the Sunyaev-Zeldovich (SZ) effect is expected to be the largest signal at mm and cm wavelengths at a resolution of a few arcminutes. We investigate some simple statistics of SZ maps and their scaling with the normalization of the matter power spectrum, σ8, as well as the effects of the unknown physics of the intracluster medium on these statistics. We show that the SZ background provides a significant background for SZ cluster searches, with the onset of confusion occurring around 1014h-1Msolar in a cosmology-dependent way, where confusion is defined as typical errors in recovered flux larger than 20 per cent. The confusion limit corresponds to the mass at which there are roughly 10 clusters per square degree, with this number nearly independent of cosmology and cluster gas physics. Typical errors grow quickly as lower mass objects are included in the catalogue. We also point out that there is nothing in particular about the rms of the filtered map that makes it especially well suited for capturing aspects of the SZ effect, and other indicators of the one-point SZ probability distribution function are at least as well suited for the task. For example, the full width at half-maximum of the one-point probability distribution has a field-to-field scatter that is about 60 per cent that of the rms. The simplest statistics of SZ maps are largely unaffected by cluster physics such as preheating, although the impact of preheating is clear by eye in the maps. Studies aimed at learning about the physics of the intracluster medium will apparently require more specialized statistical indicators.

  1. Cosmic Microwave Background Mapping

    NASA Astrophysics Data System (ADS)

    Verkhodanov, O. V.; Doroshkevich, A. G.

    2012-03-01

    The last decade of research in cosmology was connected with the ambitious experiments including space and ground base observations. Among the most impressive results of these investigations are the measurements of the cosmic microwave background (CMB) radiation like WMAP* and Planck. Exactly from the CMB studies, we have started the epoch of the precision cosmology when generally the values of cosmological parameters have been known and present research is devoted to improvement of the precision. These achievements are connected with both the creation of the new facilities in millimeter and submillimeter astronomy (e.g., satellites, receivers, antennas, computers) and development of the methods for the CMB data analysis. Actually, the process of data analysis contains several technical stages including 1. Registration of time-ordered data (TOD) 2. Pixelization of the CMB data - map preparation 3. Component separation 4. Map statistics analysis 5. Map - spherical harmonics transformation 6. C(l)-spectrum calculation and spectrum statistics analysis 7. Cosmological parameters estimation Starting from the cosmic background explorer (COBE) experiment using the so-called Quadrilateralized Sky Cube Projection (see [1-3]), the problem of the whole sky CMB pixelization has attracted great interest and many such schemes were developed. Let us note however that accurate pixelization of the CMB data on the sphere is very important but not the final step of analysis. Usually, the next step implies the determination of the coefficients of the spherical harmonic decomposition of the CMB signal for both anisotropy and polarization. This means that some of the pixelization schemes provide a very accurate map but are inconvenient for further decomposition. This also means that the choice of suitable pixelization schemes depends upon the general goals of the investigation. In this review, we consider several of the most popular sky map pixelization schemes and link them with the

  2. Characterization and Prediction of the SPI Background

    NASA Technical Reports Server (NTRS)

    Teegarden, B. J.; Jean, P.; Knodlseder, J.; Skinner, G. K.; Weidenspointer, G.

    2003-01-01

    The INTEGRAL Spectrometer, like most gamma-ray instruments, is background dominated. Signal-to-background ratios of a few percent are typical. The background is primarily due to interactions of cosmic rays in the instrument and spacecraft. It characteristically varies by +/- 5% on time scales of days. This variation is caused mainly by fluctuations in the interplanetary magnetic field that modulates the cosmic ray intensity. To achieve the maximum performance from SPI it is essential to have a high quality model of this background that can predict its value to a fraction of a percent. In this poster we characterize the background and its variability, explore various models, and evaluate the accuracy of their predictions.

  3. [Arrhythmia and genetic background].

    PubMed

    Chinushi, Masaomi; Sato, Akinori

    2013-02-01

    Recent studies have demonstrated that genetic abnormalities associated with the regulation of myocardial ionic channels, receptors, transporters, cell membranous proteins etc, can create an arrhythmogenic substrate in some patients with structurally normal hearts, and these are called hereditary arrhythmic diseases. Various arrhythmic diseases (such as congenital long or short QT syndrome, Brugada syndrome, catecholamine-sensitive polymorphic ventricular tachycardia, arrhythmogenic right ventricular cardiomyopathy, early repolarization syndrome etc.) are categorized as hereditary arrhythmic diseases. Among them, we focused on long QT syndrome and Brugada syndrome in this review. In congenital long QT syndrome, either attenuation of the net outward current or augmentation of the net inward current is responsible for prolonging the myocardial action potential duration and QT interval on ECG. Premature ventricular beats triggered due to early after-depolarization infringe on the large spatial dispersion of ventricular repolarization and initiate polymorphic ventricular tachycardia with a specific form (torsade de pointes). Currently, thirteen genotypes in Romano-Ward syndrome and two genotypes in Jervell-Lange Nielsen syndrome have been reported. In Brugada syndrome, large transient outward current (Ito) creates a deep phase 1 notch in the action potential, especially at the epicardial myocardium of the right ventricular outflow tract. In combination with the delayed completion of repolarization and loss of the phase 2 dome in some epicardial myocardium in this area, coved-type ECG abnormality and ventricular fibrillation due to phase 2 reentry are believed to be induced in Brugada syndrome. Eleven genetic abnormalities are presently listed as a possible cause of Brugada syndrome.

  4. 32 CFR 770.42 - Background.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... ACCESS TO PARTICULAR INSTALLATIONS Base Entry Regulations for Naval Submarine Base New London, Groton, Connecticut § 770.42 Background. Naval Submarine Base New London maintains and operates facilities to support training and experimental operations of the submarine force including providing support to...

  5. 32 CFR 770.42 - Background.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... ACCESS TO PARTICULAR INSTALLATIONS Base Entry Regulations for Naval Submarine Base New London, Groton, Connecticut § 770.42 Background. Naval Submarine Base New London maintains and operates facilities to support training and experimental operations of the submarine force including providing support to...

  6. 32 CFR 770.42 - Background.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... ACCESS TO PARTICULAR INSTALLATIONS Base Entry Regulations for Naval Submarine Base New London, Groton, Connecticut § 770.42 Background. Naval Submarine Base New London maintains and operates facilities to support training and experimental operations of the submarine force including providing support to...

  7. 32 CFR 770.42 - Background.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... ACCESS TO PARTICULAR INSTALLATIONS Base Entry Regulations for Naval Submarine Base New London, Groton, Connecticut § 770.42 Background. Naval Submarine Base New London maintains and operates facilities to support training and experimental operations of the submarine force including providing support to...

  8. The cosmic background explorer

    SciTech Connect

    Gulkis, G. ); Lubin, P.M. ); Meyer, S.S. ); Silverberg, R.F.

    1990-01-01

    Late last year the National Aeronautics and Space Administration launched its first satellite dedicated to the study of phenomena related to the origins of the universe. The satellite, called the Cosmic Background Explorer (COBE), carries three complementary detectors that will make fundamental measurements of the celestial radiation. Part of that radiation is believed to have originated in processes that occurred at the very dawn of the universe. By measuring the remnant radiation at wavelengths from one micrometer to one centimeter across the entire sky, scientists hope to be able to solve many mysteries regarding the origin and evolution of the early universe. Unfortunately, these radiative relics of the early universe are weak and veiled by local astrophysical and terrestrial sources of radiation. The wavelengths of the various cosmic components may also overlap, thereby making the understanding of the diffuse celestial radiation a challenge. Nevertheless, the COBE instruments, with their full-sky coverage, high sensitivity to a wide range of wavelengths and freedom from interference from the earth's atmosphere, will constitute for astrophysicists an observatory of unprecedented sensitivity and scope. The interesting cosmic signals will then be separated from one another and from noncosmic radiation sources by a comprehensive analysis of the data.

  9. Background sources in optical communications

    NASA Technical Reports Server (NTRS)

    Vilnrotter, V. A.

    1983-01-01

    The characterization and measurement of background radiation relevant to optical communications system performance is addressed. The necessary optical receiver parameters are described, and radiometric concepts required for the calculation of collected background power are developed. The most important components of optical background power are discussed, and their contribution to the total collected background power in various communications scenarios is examined.

  10. Integrable Background Geometries

    NASA Astrophysics Data System (ADS)

    Calderbank, David M. J.

    2014-03-01

    This work has its origins in an attempt to describe systematically the integrable geometries and gauge theories in dimensions one to four related to twistor theory. In each such dimension, there is a nondegenerate integrable geometric structure, governed by a nonlinear integrable differential equation, and each solution of this equation determines a background geometry on which, for any Lie group G, an integrable gauge theory is defined. In four dimensions, the geometry is selfdual conformal geometry and the gauge theory is selfdual Yang-Mills theory, while the lower-dimensional structures are nondegenerate (i.e., non-null) reductions of this. Any solution of the gauge theory on a k-dimensional geometry, such that the gauge group H acts transitively on an ℓ-manifold, determines a (k+ℓ)-dimensional geometry (k+ℓ≤4) fibering over the k-dimensional geometry with H as a structure group. In the case of an ℓ-dimensional group H acting on itself by the regular representation, all (k+ℓ)-dimensional geometries with symmetry group H are locally obtained in this way. This framework unifies and extends known results about dimensional reductions of selfdual conformal geometry and the selfdual Yang-Mills equation, and provides a rich supply of constructive methods. In one dimension, generalized Nahm equations provide a uniform description of four pole isomonodromic deformation problems, and may be related to the {SU}(∞) Toda and dKP equations via a hodograph transformation. In two dimensions, the {Diff}(S^1) Hitchin equation is shown to be equivalent to the hyperCR Einstein-Weyl equation, while the {SDiff}(Σ^2) Hitchin equation leads to a Euclidean analogue of Plebanski's heavenly equations. In three and four dimensions, the constructions of this paper help to organize the huge range of examples of Einstein-Weyl and selfdual spaces in the literature, as well as providing some new ! ones. The nondegenerate reductions have a long ancestry. More ! recently

  11. High-energy radiation background in space

    NASA Astrophysics Data System (ADS)

    Rester, A. C., Jr.; Trombka, J. I.

    The radiation environment of near-earth space and its effects on biological and hardware systems are examined in reviews and reports. Sections are devoted to particle interactions and propagation, data bases, instrument background and dosimetry, detectors and experimental progress, biological effects, and future needs and strategies. Particular attention is given to angular distributions and spectra of geomagnetically trapped protons in LEO, bremsstrahlung production by electrons, nucleon-interaction data bases for background estimates, instrumental and atmospheric background lines observed by the SMM gamma-ray spectrometer, the GRAD high-altitude balloon flight over Antarctica, space protons and brain tumors, a new radioprotective antioxidative agent, LEO radiation measurements on the Space Station, and particle-background effects on the Hubble Space Telescope and the Lyman FUV Spectroscopic Explorer.

  12. High-energy radiation background in space

    NASA Technical Reports Server (NTRS)

    Rester, A. C., Jr. (Editor); Trombka, J. I. (Editor)

    1989-01-01

    The radiation environment of near-earth space and its effects on biological and hardware systems are examined in reviews and reports. Sections are devoted to particle interactions and propagation, data bases, instrument background and dosimetry, detectors and experimental progress, biological effects, and future needs and strategies. Particular attention is given to angular distributions and spectra of geomagnetically trapped protons in LEO, bremsstrahlung production by electrons, nucleon-interaction data bases for background estimates, instrumental and atmospheric background lines observed by the SMM gamma-ray spectrometer, the GRAD high-altitude balloon flight over Antarctica, space protons and brain tumors, a new radioprotective antioxidative agent, LEO radiation measurements on the Space Station, and particle-background effects on the Hubble Space Telescope and the Lyman FUV Spectroscopic Explorer.

  13. Neutron background measurements at China Jinping underground laboratory with a Bonner multi-sphere spectrometer

    NASA Astrophysics Data System (ADS)

    Hu, Qingdong; Ma, Hao; Zeng, Zhi; Cheng, Jianping; Chen, Yunhua; He, Shengming; Li, Junli; Shen, Manbin; Wu, Shiyong; Yue, Qian; Yue, Jianfeng; Zhang, Hui

    2017-07-01

    The neutron background spectrum from thermal neutron to 20 MeV fast neutron was measured at the first experimental hall of China Jinping underground laboratory with a Bonner multi-sphere spectrometer. The measurement system was validated by a 252Cf source and inconformity was corrected. Due to micro charge discharge, the dataset was screened and background from the steel of the detectors was estimated by MC simulation. Based on genetic algorithm we obtained the energy distribution of the neutron and the total flux of neutron was (2.69±1.02) ×10-5 cm-2 s-1.

  14. Orbital period of a satellite of a planet in the relativistic theory of gravitation and in general relativity and the possibility of experimental verification of delay due to gravitational interaction

    SciTech Connect

    Logunov, A.A.; Loskutov, Yu.M.

    1986-10-01

    The orbital period of a satellite revolving around a planet is calculated in the framework of the relativistic theory of gravitation and in general relativity. The difference between the theoretical predictions is amenable to experimental verification.

  15. 16 CFR 1402.2 - Background.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... ANTENNAS, TV ANTENNAS, AND SUPPORTING STRUCTURES § 1402.2 Background. As a result of numerous... and their supporting structures so that consumers can be made aware of the hazards involved and of... antennas, outside TV antennas, and supporting structures due to contact with overhead powerlines....

  16. 16 CFR 1402.2 - Background.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... ANTENNAS, TV ANTENNAS, AND SUPPORTING STRUCTURES § 1402.2 Background. As a result of numerous... and their supporting structures so that consumers can be made aware of the hazards involved and of... antennas, outside TV antennas, and supporting structures due to contact with overhead powerlines....

  17. 16 CFR 1402.2 - Background.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... ANTENNAS, TV ANTENNAS, AND SUPPORTING STRUCTURES § 1402.2 Background. As a result of numerous... and their supporting structures so that consumers can be made aware of the hazards involved and of... antennas, outside TV antennas, and supporting structures due to contact with overhead powerlines....

  18. 16 CFR 1402.2 - Background.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... ANTENNAS, TV ANTENNAS, AND SUPPORTING STRUCTURES § 1402.2 Background. As a result of numerous... and their supporting structures so that consumers can be made aware of the hazards involved and of... antennas, outside TV antennas, and supporting structures due to contact with overhead powerlines....

  19. 16 CFR 1402.2 - Background.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... ANTENNAS, TV ANTENNAS, AND SUPPORTING STRUCTURES § 1402.2 Background. As a result of numerous... and their supporting structures so that consumers can be made aware of the hazards involved and of... antennas, outside TV antennas, and supporting structures due to contact with overhead powerlines....

  20. 45 CFR 650.16 - Background rights.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 45 Public Welfare 3 2013-10-01 2013-10-01 false Background rights. 650.16 Section 650.16 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL SCIENCE FOUNDATION PATENTS § 650.16... in exceptional circumstances where, due to the nature of the research being supported, the...

  1. 45 CFR 650.16 - Background rights.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Welfare Regulations Relating to Public Welfare (Continued) NATIONAL SCIENCE FOUNDATION PATENTS § 650.16 Background rights. The Foundation will acquire rights to a research performer's pre-existing technology only in exceptional circumstances where, due to the nature of the research being supported, the Foundation...

  2. 45 CFR 650.16 - Background rights.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Welfare Regulations Relating to Public Welfare (Continued) NATIONAL SCIENCE FOUNDATION PATENTS § 650.16 Background rights. The Foundation will acquire rights to a research performer's pre-existing technology only in exceptional circumstances where, due to the nature of the research being supported, the Foundation...

  3. Background Light Bluer Than Expected

    NASA Image and Video Library

    2014-11-06

    This plot shows data from the Cosmic Infrared Background Experiment, or CIBER, rockets launched in 2010 and 2012. The experiment measures a diffuse glow of infrared light in the sky, known as the cosmic infrared background.

  4. Marginal Aggregates in Flexible Pavements: Background Survey and Experimental Plan

    DTIC Science & Technology

    1994-08-01

    of asphalt concrete mixtures. A review of this research has been conducted and summarized into general categories that best relate to marginal... concrete mixtures. A review of this research has been conducted and summarized into general categories that best relate to marginal aggregates as defined by...Aggregate on Properties of Bituminous Concrete ," Pennsylvania Department of Transportation, Research Project Report 70-28. 23. Ahlrich, R. C. 1991. "The

  5. CERN-derived analysis of lunar radiation backgrounds

    NASA Technical Reports Server (NTRS)

    Wilson, Thomas L.; Svoboda, Robert

    1993-01-01

    The Moon produces radiation which background-limits scientific experiments there. Early analyses of these backgrounds have either failed to take into consideration the effect of charm in particle physics (because they pre-dated its discovery), or have used branching ratios which are no longer strictly valid (due to new accelerator data). We are presently investigating an analytical program for deriving muon and neutrino spectra generated by the Moon, converting an existing CERN computer program known as GEANT which does the same for the Earth. In so doing, this will (1) determine an accurate prompt neutrino spectrum produced by the lunar surface; (2) determine the lunar subsurface particle flux; (3) determine the consequence of charm production physics upon the lunar background radiation environment; and (4) provide an analytical tool for the NASA astrophysics community with which to begin an assessment of the Moon as a scientific laboratory versus its particle radiation environment. This will be done on a recurring basis with the latest experimental results of the particle data groups at Earth-based high-energy accelerators, in particular with the latest branching ratios for charmed meson decay. This will be accomplished for the first time as a full 3-dimensional simulation.

  6. Binarization algorithm for document image with complex background

    NASA Astrophysics Data System (ADS)

    Miao, Shaojun; Lu, Tongwei; Min, Feng

    2015-12-01

    The most important step in image preprocessing for Optical Character Recognition (OCR) is binarization. Due to the complex background or varying light in the text image, binarization is a very difficult problem. This paper presents the improved binarization algorithm. The algorithm can be divided into several steps. First, the background approximation can be obtained by the polynomial fitting, and the text is sharpened by using bilateral filter. Second, the image contrast compensation is done to reduce the impact of light and improve contrast of the original image. Third, the first derivative of the pixels in the compensated image are calculated to get the average value of the threshold, then the edge detection is obtained. Fourth, the stroke width of the text is estimated through a measuring of distance between edge pixels. The final stroke width is determined by choosing the most frequent distance in the histogram. Fifth, according to the value of the final stroke width, the window size is calculated, then a local threshold estimation approach can begin to binaries the image. Finally, the small noise is removed based on the morphological operators. The experimental result shows that the proposed method can effectively remove the noise caused by complex background and varying light.

  7. The efficiency of reading around learned backgrounds

    NASA Astrophysics Data System (ADS)

    Eckstein, Miguel P.; Pham, Binh T.; Abbey, Craig K.; Zhang, Yani

    2006-03-01

    Most metrics of medical image quality typically treat all variability components of the background as a Gaussian noise process. This includes task based model observers (non-prewhitening matched filter without and with an eye filter, NPW and NPWE; Hotelling and Channelized Hotelling) as well as Fourier metrics of medical image quality based on the noise power spectra. However, many investigators have observed that unlike many of the models/metrics, physicians often can discount signal-looking structures that are part of the normal anatomic background. This process has been referred to as reading around the background or noise. The purpose of this paper is to develop an experimental framework to systematically study the ability of human observers to read around learned backgrounds and compare their ability to that of an optimal ideal observer which has knowledge of the background. We measured human localization performance of one of twelve targets in the presence of a fixed background consisting of randomly placed Gaussians with random contrasts and sizes, and white noise. Performance was compared to a condition in which the test images contained only white noise but with higher contrast. Human performance was compared to standard model observers that treat the background as a Gaussian noise process (NPW, NPWE and Hotelling), a Fourier-based prewhitening matched filter, and an ideal observer. The Hotelling, NPW, NPWE models as well as the Fourier-based prewhitening matched filter predicted higher performance for the white noise test images than the background plus white noise. In contrast, ideal and human performance was higher for the background plus white noise condition. Furthermore, human performance exceeded that of the NPW, NPWE and Hotelling models and reached an efficiency of 19% relative to the ideal observer. Our results demonstrate that for some types of images human signal localization performance is consistent with use of knowledge about the high order

  8. Beam induced backgrounds: CDF experience

    SciTech Connect

    Tesarek, R.J.; /Fermilab

    2008-05-01

    We summarize the experiences of the Collider Detector at Fermilab (CDF) experiment in the presence of backgrounds originating from the counter circulating beams in the Fermilab Tevatron. These backgrounds are measured and their sources identified. Finally, we outline the strategies employed to reduce the effects of these backgrounds on the experiment.

  9. Neurobiological background of negative symptoms.

    PubMed

    Galderisi, Silvana; Merlotti, Eleonora; Mucci, Armida

    2015-10-01

    Studies investigating neurobiological bases of negative symptoms of schizophrenia failed to provide consistent findings, possibly due to the heterogeneity of this psychopathological construct. We tried to review the findings published to date investigating neurobiological abnormalities after reducing the heterogeneity of the negative symptoms construct. The literature in electronic databases as well as citations and major articles are reviewed with respect to the phenomenology, pathology, genetics and neurobiology of schizophrenia. We searched PubMed with the keywords "negative symptoms," "deficit schizophrenia," "persistent negative symptoms," "neurotransmissions," "neuroimaging" and "genetic." Additional articles were identified by manually checking the reference lists of the relevant publications. Publications in English were considered, and unpublished studies, conference abstracts and poster presentations were not included. Structural and functional imaging studies addressed the issue of neurobiological background of negative symptoms from several perspectives (considering them as a unitary construct, focusing on primary and/or persistent negative symptoms and, more recently, clustering them into factors), but produced discrepant findings. The examined studies provided evidence suggesting that even primary and persistent negative symptoms include different psychopathological constructs, probably reflecting the dysfunction of different neurobiological substrates. Furthermore, they suggest that complex alterations in multiple neurotransmitter systems and genetic variants might influence the expression of negative symptoms in schizophrenia. On the whole, the reviewed findings, representing the distillation of a large body of disparate data, suggest that further deconstruction of negative symptomatology into more elementary components is needed to gain insight into underlying neurobiological mechanisms.

  10. Extragalactic background light measurements and applications

    PubMed Central

    Cooray, Asantha

    2016-01-01

    This review covers the measurements related to the extragalactic background light intensity from γ-rays to radio in the electromagnetic spectrum over 20 decades in wavelength. The cosmic microwave background (CMB) remains the best measured spectrum with an accuracy better than 1%. The measurements related to the cosmic optical background (COB), centred at 1 μm, are impacted by the large zodiacal light associated with interplanetary dust in the inner Solar System. The best measurements of COB come from an indirect technique involving γ-ray spectra of bright blazars with an absorption feature resulting from pair-production off of COB photons. The cosmic infrared background (CIB) peaking at around 100 μm established an energetically important background with an intensity comparable to the optical background. This discovery paved the way for large aperture far-infrared and sub-millimetre observations resulting in the discovery of dusty, starbursting galaxies. Their role in galaxy formation and evolution remains an active area of research in modern-day astrophysics. The extreme UV (EUV) background remains mostly unexplored and will be a challenge to measure due to the high Galactic background and absorption of extragalactic photons by the intergalactic medium at these EUV/soft X-ray energies. We also summarize our understanding of the spatial anisotropies and angular power spectra of intensity fluctuations. We motivate a precise direct measurement of the COB between 0.1 and 5 μm using a small aperture telescope observing either from the outer Solar System, at distances of 5 AU or more, or out of the ecliptic plane. Other future applications include improving our understanding of the background at TeV energies and spectral distortions of CMB and CIB. PMID:27069645

  11. Extragalactic background light measurements and applications.

    PubMed

    Cooray, Asantha

    2016-03-01

    This review covers the measurements related to the extragalactic background light intensity from γ-rays to radio in the electromagnetic spectrum over 20 decades in wavelength. The cosmic microwave background (CMB) remains the best measured spectrum with an accuracy better than 1%. The measurements related to the cosmic optical background (COB), centred at 1 μm, are impacted by the large zodiacal light associated with interplanetary dust in the inner Solar System. The best measurements of COB come from an indirect technique involving γ-ray spectra of bright blazars with an absorption feature resulting from pair-production off of COB photons. The cosmic infrared background (CIB) peaking at around 100 μm established an energetically important background with an intensity comparable to the optical background. This discovery paved the way for large aperture far-infrared and sub-millimetre observations resulting in the discovery of dusty, starbursting galaxies. Their role in galaxy formation and evolution remains an active area of research in modern-day astrophysics. The extreme UV (EUV) background remains mostly unexplored and will be a challenge to measure due to the high Galactic background and absorption of extragalactic photons by the intergalactic medium at these EUV/soft X-ray energies. We also summarize our understanding of the spatial anisotropies and angular power spectra of intensity fluctuations. We motivate a precise direct measurement of the COB between 0.1 and 5 μm using a small aperture telescope observing either from the outer Solar System, at distances of 5 AU or more, or out of the ecliptic plane. Other future applications include improving our understanding of the background at TeV energies and spectral distortions of CMB and CIB.

  12. Enhancements to the MCNP6 background source

    DOE PAGES

    McMath, Garrett E.; McKinney, Gregg W.

    2015-10-19

    The particle transport code MCNP has been used to produce a background radiation data file on a worldwide grid that can easily be sampled as a source in the code. Location-dependent cosmic showers were modeled by Monte Carlo methods to produce the resulting neutron and photon background flux at 2054 locations around Earth. An improved galactic-cosmic-ray feature was used to model the source term as well as data from multiple sources to model the transport environment through atmosphere, soil, and seawater. A new elevation scaling feature was also added to the code to increase the accuracy of the cosmic neutronmore » background for user locations with off-grid elevations. Furthermore, benchmarking has shown the neutron integral flux values to be within experimental error.« less

  13. Enhancements to the MCNP6 background source

    SciTech Connect

    McMath, Garrett E.; McKinney, Gregg W.

    2015-10-19

    The particle transport code MCNP has been used to produce a background radiation data file on a worldwide grid that can easily be sampled as a source in the code. Location-dependent cosmic showers were modeled by Monte Carlo methods to produce the resulting neutron and photon background flux at 2054 locations around Earth. An improved galactic-cosmic-ray feature was used to model the source term as well as data from multiple sources to model the transport environment through atmosphere, soil, and seawater. A new elevation scaling feature was also added to the code to increase the accuracy of the cosmic neutron background for user locations with off-grid elevations. Furthermore, benchmarking has shown the neutron integral flux values to be within experimental error.

  14. Background

    NASA Technical Reports Server (NTRS)

    1976-01-01

    An analysis was made of the UF6 fueled gas core reactor as a function of cavity reactor criticality and fluid mechanics tests, investigations of uranium optical emission spectra, and radiant heat transfer power plant studies. Data are also given on nuclear and thermodynamic cycle analysis.

  15. X-ray absorption spectroscopy to determine originating depth of electrons that form an inelastic background of Auger electron spectrum

    NASA Astrophysics Data System (ADS)

    Isomura, Noritake; Cui, Yi-Tao; Murai, Takaaki; Oji, Hiroshi; Kimoto, Yasuji

    2017-07-01

    In Auger electron spectroscopy (AES), the spectral background is mainly due to inelastic scattering of Auger electrons that lose their kinetic energy in a sample bulk. To investigate the spectral components within this background for SiO2(19.3 nm)/Si(100) with known layer thickness, X-ray absorption spectroscopy (XAS) was used in the partial-electron-yield (PEY) mode at several electron kinetic energies to probe the background of the Si KLL Auger peak. The Si K-edge PEY-XAS spectra constituted of both Si and SiO2 components at each kinetic energy, and their component fractions were approximately the same as those derived from the simulated AES background for the same sample structure. The contributions of Auger electrons originating from layers at different depths to the inelastic background could thus be identified experimentally.

  16. Diffuse Cosmic Infrared Background Radiation

    NASA Technical Reports Server (NTRS)

    Dwek, Eli

    2002-01-01

    The diffuse cosmic infrared background (CIB) consists of the cumulative radiant energy released in the processes of structure formation that have occurred since the decoupling of matter and radiation following the Big Bang. In this lecture I will review the observational data that provided the first detections and limits on the CIB, and the theoretical studies explaining the origin of this background. Finally, I will also discuss the relevance of this background to the universe as seen in high energy gamma-rays.

  17. Diffuse Cosmic Infrared Background Radiation

    NASA Technical Reports Server (NTRS)

    Dwek, Eli

    2002-01-01

    The diffuse cosmic infrared background (CIB) consists of the cumulative radiant energy released in the processes of structure formation that have occurred since the decoupling of matter and radiation following the Big Bang. In this lecture I will review the observational data that provided the first detections and limits on the CIB, and the theoretical studies explaining the origin of this background. Finally, I will also discuss the relevance of this background to the universe as seen in high energy gamma-rays.

  18. Estimating radiological background using imaging spectroscopy

    SciTech Connect

    Bernacki, Bruce E.; Schweppe, John E.; Stave, Sean C.; Jordan, David V.; Kulisek, Jonathan A.; Stewart, Trevor N.; Seifert, Carolyn E.

    2014-06-13

    Optical imaging spectroscopy is investigated as a method to estimate radiological background by spectral identification of soils, sediments, rocks, minerals and building materials derived from natural materials and assigning tabulated radiological emission values to these materials. Radiological airborne surveys are undertaken by local, state and federal agencies to identify the presence of radiological materials out of regulatory compliance. Detection performance in such surveys is determined by (among other factors) the uncertainty in the radiation background; increased knowledge of the expected radiation background will improve the ability to detect low-activity radiological materials. Radiological background due to naturally occurring radiological materials (NORM) can be estimated by reference to previous survey results, use of global 40K, 238U, and 232Th (KUT) values, reference to existing USGS radiation background maps, or by a moving average of the data as it is acquired. Each of these methods has its drawbacks: previous survey results may not include recent changes, the global average provides only a zero-order estimate, the USGS background radiation map resolutions are coarse and are accurate only to 1 km – 25 km sampling intervals depending on locale, and a moving average may essentially low pass filter the data to obscure small changes in radiation counts. Imaging spectroscopy from airborne or spaceborne platforms can offer higher resolution identification of materials and background, as well as provide imaging context information. AVIRIS hyperspectral image data is analyzed using commercial exploitation software to determine the usefulness of imaging spectroscopy to identify qualitative radiological background emissions when compared to airborne radiological survey data.

  19. Cosmic Microwave Background Data Analysis

    NASA Astrophysics Data System (ADS)

    Paykari, Paniez; Starck, Jean-Luc Starck

    2012-03-01

    About 400,000 years after the Big Bang the temperature of the Universe fell to about a few thousand degrees. As a result, the previously free electrons and protons combined and the Universe became neutral. This released a radiation which we now observe as the cosmic microwave background (CMB). The tiny fluctuations* in the temperature and polarization of the CMB carry a wealth of cosmological information. These so-called temperature anisotropies were predicted as the imprints of the initial density perturbations which gave rise to the present large-scale structures such as galaxies and clusters of galaxies. This relation between the present-day Universe and its initial conditions has made the CMB radiation one of the most preferred tools to understand the history of the Universe. The CMB radiation was discovered by radio astronomers Arno Penzias and Robert Wilson in 1965 [72] and earned them the 1978 Nobel Prize. This discovery was in support of the Big Bang theory and ruled out the only other available theory at that time - the steady-state theory. The crucial observations of the CMB radiation were made by the Far-Infrared Absolute Spectrophotometer (FIRAS) instrument on the Cosmic Background Explorer (COBE) satellite [86]- orbited in 1989-1996. COBE made the most accurate measurements of the CMB frequency spectrum and confirmed it as being a black-body to within experimental limits. This made the CMB spectrum the most precisely measured black-body spectrum in nature. The CMB has a thermal black-body spectrum at a temperature of 2.725 K: the spectrum peaks in the microwave range frequency of 160.2 GHz, corresponding to a 1.9mmwavelength. The results of COBE inspired a series of ground- and balloon-based experiments, which measured CMB anisotropies on smaller scales over the next decade. During the 1990s, the first acoustic peak of the CMB power spectrum (see Figure 5.1) was measured with increasing sensitivity and by 2000 the BOOMERanG experiment [26] reported

  20. Measuring anisotropies in the cosmic neutrino background

    NASA Astrophysics Data System (ADS)

    Lisanti, Mariangela; Safdi, Benjamin R.; Tully, Christopher G.

    2014-10-01

    Neutrino capture on tritium has emerged as a promising method for detecting the cosmic neutrino background (C ν B ). We show that relic neutrinos are captured most readily when their spin vectors are antialigned with the polarization axis of the tritium nuclei and when they approach along the direction of polarization. As a result, C ν B observatories may measure anisotropies in the cosmic neutrino velocity and spin distributions by polarizing the tritium targets. A small dipole anisotropy in the C ν B is expected due to the peculiar velocity of the lab frame with respect to the cosmic frame and due to late-time gravitational effects. The PTOLEMY experiment, a tritium observatory currently under construction, should observe a nearly isotropic background. This would serve as a strong test of the cosmological origin of a potential signal. The polarized-target measurements may also constrain nonstandard neutrino interactions that would induce larger anisotropies and help discriminate between Majorana versus Dirac neutrinos.

  1. Visual signal detection in structured backgrounds. II. Effects of contrast gain control, background variations, and white noise

    NASA Technical Reports Server (NTRS)

    Eckstein, M. P.; Ahumada, A. J. Jr; Watson, A. B.

    1997-01-01

    Studies of visual detection of a signal superimposed on one of two identical backgrounds show performance degradation when the background has high contrast and is similar in spatial frequency and/or orientation to the signal. To account for this finding, models include a contrast gain control mechanism that pools activity across spatial frequency, orientation and space to inhibit (divisively) the response of the receptor sensitive to the signal. In tasks in which the observer has to detect a known signal added to one of M different backgrounds grounds due to added visual noise, the main sources of degradation are the stochastic noise in the image and the suboptimal visual processing. We investigate how these two sources of degradation (contrast gain control and variations in the background) interact in a task in which the signal is embedded in one of M locations in a complex spatially varying background (structured background). We use backgrounds extracted from patient digital medical images. To isolate effects of the fixed deterministic background (the contrast gain control) from the effects of the background variations, we conduct detection experiments with three different background conditions: (1) uniform background, (2) a repeated sample of structured background, and (3) different samples of structured background. Results show that human visual detection degrades from the uniform background condition to the repeated background condition and degrades even further in the different backgrounds condition. These results suggest that both the contrast gain control mechanism and the background random variations degrade human performance in detection of a signal in a complex, spatially varying background. A filter model and added white noise are used to generate estimates of sampling efficiencies, an equivalent internal noise, an equivalent contrast-gain-control-induced noise, and an equivalent noise due to the variations in the structured background.

  2. Visual signal detection in structured backgrounds. II. Effects of contrast gain control, background variations, and white noise

    NASA Technical Reports Server (NTRS)

    Eckstein, M. P.; Ahumada, A. J. Jr; Watson, A. B.

    1997-01-01

    Studies of visual detection of a signal superimposed on one of two identical backgrounds show performance degradation when the background has high contrast and is similar in spatial frequency and/or orientation to the signal. To account for this finding, models include a contrast gain control mechanism that pools activity across spatial frequency, orientation and space to inhibit (divisively) the response of the receptor sensitive to the signal. In tasks in which the observer has to detect a known signal added to one of M different backgrounds grounds due to added visual noise, the main sources of degradation are the stochastic noise in the image and the suboptimal visual processing. We investigate how these two sources of degradation (contrast gain control and variations in the background) interact in a task in which the signal is embedded in one of M locations in a complex spatially varying background (structured background). We use backgrounds extracted from patient digital medical images. To isolate effects of the fixed deterministic background (the contrast gain control) from the effects of the background variations, we conduct detection experiments with three different background conditions: (1) uniform background, (2) a repeated sample of structured background, and (3) different samples of structured background. Results show that human visual detection degrades from the uniform background condition to the repeated background condition and degrades even further in the different backgrounds condition. These results suggest that both the contrast gain control mechanism and the background random variations degrade human performance in detection of a signal in a complex, spatially varying background. A filter model and added white noise are used to generate estimates of sampling efficiencies, an equivalent internal noise, an equivalent contrast-gain-control-induced noise, and an equivalent noise due to the variations in the structured background.

  3. Apparatus for reducing solvent luminescence background emissions

    DOEpatents

    Affleck, Rhett L.; Ambrose, W. Patrick; Demas, James N.; Goodwin, Peter M.; Johnson, Mitchell E.; Keller, Richard A.; Petty, Jeffrey T.; Schecker, Jay A.; Wu, Ming

    1998-01-01

    The detectability of luminescent molecules in solution is enhanced by reducing the background luminescence due to impurity species also present in the solution. A light source that illuminates the solution acts to photolyze the impurities so that the impurities do not luminesce in the fluorescence band of the molecule of interest. Molecules of interest may be carried through the photolysis region in the solution or may be introduced into the solution after the photolysis region.

  4. Apparatus for reducing solvent luminescence background emissions

    DOEpatents

    Affleck, R.L.; Ambrose, W.P.; Demas, J.N.; Goodwin, P.M.; Johnson, M.E.; Keller, R.A.; Petty, J.T.; Schecker, J.A.; Wu, M.

    1998-11-10

    The detectability of luminescent molecules in solution is enhanced by reducing the background luminescence due to impurity species also present in the solution. A light source that illuminates the solution acts to photolyze the impurities so that the impurities do not luminesce in the fluorescence band of the molecule of interest. Molecules of interest may be carried through the photolysis region in the solution or may be introduced into the solution after the photolysis region. 6 figs.

  5. Background reduction in cryogenic detectors

    SciTech Connect

    Bauer, Daniel A.; /Fermilab

    2005-04-01

    This paper discusses the background reduction and rejection strategy of the Cryogenic Dark Matter Search (CDMS) experiment. Recent measurements of background levels from CDMS II at Soudan are presented, along with estimates for future improvements in sensitivity expected for a proposed SuperCDMS experiment at SNOLAB.

  6. Computerized Placement Tests: Background Readings.

    ERIC Educational Resources Information Center

    College Entrance Examination Board, Princeton, NJ.

    This document is a compilation of background readings for the user of Computerized Placement Tests (CPTs) developed by the College Board for student placement purposes. CPTs are computerized adaptive tests that test the individual abilities and backgrounds of examinees. CPTs are part of the ACCUPLACER student information management system. The…

  7. Lattice QCD in Background Fields

    SciTech Connect

    William Detmold, Brian Tiburzi, Andre Walker-Loud

    2009-06-01

    Electromagnetic properties of hadrons can be computed by lattice simulations of QCD in background fields. We demonstrate new techniques for the investigation of charged hadron properties in electric fields. Our current calculations employ large electric fields, motivating us to analyze chiral dynamics in strong QED backgrounds, and subsequently uncover surprising non-perturbative effects present at finite volume.

  8. Simulation Studies of Backgrounds for the Fermilab SeaQuest Experiment (E906)

    NASA Astrophysics Data System (ADS)

    Ma, Puyang; Aidala, Christine; E906/SeaQuest Collaboration

    2016-09-01

    The Fermilab SeaQuest experiment uses a 120 GeV proton beam on targets of liquid hydrogen, liquid deuterium, and solid nuclear targets of carbon, iron, and tungsten. The experiment measures the Drell-Yan process of quark-antiquark annihilation to produce muon pairs, with the main physics goal of studying the sea quark distributions in the nucleon and nuclei. Since quark and antiquark annihilation to dimuons is a rare process, there are significant backgrounds due to muons from the decay of pions produced in the target and beam dump. These backgrounds are being studied via simulated proton interactions in a GEANT implementation of the experimental setup. Full simulation of these backgrounds has proved to be difficult because of the extensive computer time needed. Studies to speed up the simulation process will be presented. NSF.

  9. Background events in microchannel plates

    NASA Technical Reports Server (NTRS)

    Siegmund, O. H. W.; Vallerga, J.; Wargelin, B.

    1988-01-01

    Measurements have been made to assess the characteristics and origins of background events in microchannel plates (MCPs). An overall background rate of about 0.4 events/sq cm persec has been achieved consistently for MCPs that have been baked and scrubbed. The temperature and gain of the MCPs are found to have no significant effect on the background rate. Detection of 1.46-MeV gamma rays from the MCP glass confirms the presence of K-40, with a concentration of 0.0007 percent, in MCP glass. It is shown that beta decay from K-40 is sufficient to cause the background rate and spectrum observed. Anticoincidence measurements indicate the the background rate caused by cosmic ray interactions is small (less than 0.016 events/sq cm per sec).

  10. Background events in microchannel plates

    NASA Technical Reports Server (NTRS)

    Siegmund, O. H. W.; Vallerga, J.; Wargelin, B.

    1988-01-01

    Measurements have been made to assess the characteristics and origins of background events in microchannel plates (MCPs). An overall background rate of about 0.4 events/sq cm persec has been achieved consistently for MCPs that have been baked and scrubbed. The temperature and gain of the MCPs are found to have no significant effect on the background rate. Detection of 1.46-MeV gamma rays from the MCP glass confirms the presence of K-40, with a concentration of 0.0007 percent, in MCP glass. It is shown that beta decay from K-40 is sufficient to cause the background rate and spectrum observed. Anticoincidence measurements indicate the the background rate caused by cosmic ray interactions is small (less than 0.016 events/sq cm per sec).

  11. A review on natural background radiation

    PubMed Central

    Shahbazi-Gahrouei, Daryoush; Gholami, Mehrdad; Setayandeh, Samaneh

    2013-01-01

    The world is naturally radioactive and approximately 82% of human-absorbed radiation doses, which are out of control, arise from natural sources such as cosmic, terrestrial, and exposure from inhalation or intake radiation sources. In recent years, several international studies have been carried out, which have reported different values regarding the effect of background radiation on human health. Gamma radiation emitted from natural sources (background radiation) is largely due to primordial radionuclides, mainly 232Th and 238U series, and their decay products, as well as 40K, which exist at trace levels in the earth's crust. Their concentrations in soil, sands, and rocks depend on the local geology of each region in the world. Naturally occurring radioactive materials generally contain terrestrial-origin radionuclides, left over since the creation of the earth. In addition, the existence of some springs and quarries increases the dose rate of background radiation in some regions that are known as high level background radiation regions. The type of building materials used in houses can also affect the dose rate of background radiations. The present review article was carried out to consider all of the natural radiations, including cosmic, terrestrial, and food radiation. PMID:24223380

  12. Measurements of the cosmic background radiation

    NASA Technical Reports Server (NTRS)

    Weiss, R.

    1980-01-01

    Measurements of the attributes of the 2.7-K microwave background radiation (CBR) are reviewed, with emphasis on the analytic phase of CBR studies. Methods for the direct measurement of the CBR spectrum are discussed; attention is given to receivers, antennas, absolute receiver calibration, atmospheric emission and absorption, the galactic background contribution, the analysis of LF measurements, and recent HF observations of the CBR spectrum. Measurements of the large-angular-scale intensity distribution of the CBR (the most convincing evidence that the radiation is of cosmological origin) are examined, along with limits on the linear polarization of the CBR. A description is given of the NASA-sponsored Cosmic Background Explorer (COBE) satellite mission. The results of the COBE mission will be a set of sky maps showing, in the wave number range from 1 to 10,000 kaysers, the galactic background radiation due to synchrotron emission from galactic cosmic rays, to diffuse thermal emission from H II regions, and to diffuse thermal emission from interstellar and interplanetary dust, as well as a residue consisting of the CBR and whatever other cosmological background might exist.

  13. Measurements of the cosmic background radiation

    SciTech Connect

    Weiss, R.

    1980-01-01

    Measurements of the attributes of the 2.7-K microwave background radiation (CBR) are reviewed, with emphasis on the analytic phase of CBR studies. Methods for the direct measurement of the CBR spectrum are discussed. Attention is given to receivers, antennas, absolute receiver calibration, atmospheric emission and absorption, the galactic background contribution, the analysis of LF measurements, and recent HF observations of the CBR spectrum. Measurements of the large-angular-scale intensity distribution of the CBR (the most convincing evidence that the radiation is of cosmological origin) are examined, along with limits on the linear polarization of the CBR. A description is given of the NASA-sponsored Cosmic Background Explorer (COBE) satellite mission. The results of the COBE mission will be a set of sky maps showing, in the wave number range from 1 to 10,000 kaysers, the galactic background radiation due to synchrotron emission from galactic cosmic rays, to diffuse thermal emission from H II regions, and to diffuse thermal emission from interstellar and interplanetary dust, as well as a residue consisting of the CBR and whatever other cosmological background might exist.

  14. Low background counting at the LBNL low background facility

    SciTech Connect

    Thomas, K. J.; Norman, E. B.; Smith, A. R.; Chan, Y. D.; Hurley, D. L.; Wang, B. S.

    2013-08-08

    The Low Background Facility (LBF) at the Lawrence Berkeley National Laboratory (LBNL) in Berkeley, California provides low background gamma spectroscopy services to end-users in two unique facilities: locally within a carefully-constructed, low background laboratory space; and a satellite underground station (600 m.w.e) in Oroville, CA. These facilities provide a variety of gamma spectroscopy services to low background experiments primarily in the form of passive material screening for primordial radioisotopes (U, Th, K) or common cosmogenic and anthropogenic products, as well as active screening via neutron activation analysis for specific applications. A general overview of the facilities, services, and capabilities will be discussed. Recent activities will also be presented, including the recent installation of a 3π muon veto at the surface facility, cosmogenic activation studies of TeO{sub 2} for CUORE, and environmental monitoring of Fukushima fallout.

  15. Aluminum as a source of background in low background experiments

    NASA Astrophysics Data System (ADS)

    Majorovits, B.; Abt, I.; Laubenstein, M.; Volynets, O.

    2011-08-01

    Neutrinoless double beta decay would be a key to understanding the nature of neutrino masses. The next generation of High Purity Germanium experiments will have to be operated with a background rate of better than 10 -5 counts/(kg y keV) in the region of interest around the Q-value of the decay. Therefore, so far irrelevant sources of background have to be considered. The metalization of the surface of germanium detectors is in general done with aluminum. The background from the decays of 22Na, 26Al, 226Ra and 228Th introduced by this metalization is discussed. It is shown that only a special selection of aluminum can keep these background contributions acceptable.

  16. Onychomycosis Due to Nondermatophytic Molds

    PubMed Central

    Hwang, Sung Min; Ha, Gyoung Yim

    2012-01-01

    Background Although there have been many studies about onychomycosis due to nondermatophytic molds (NDM), few studies about etiologic agents including NDM in onychomycosis have been reported in Korea. Objective: This study investigated onychomycosis due to NDM in the Gyeongju area of Korea. Objective This study investigated onychomycosis due to NDM in the Gyeongju area of Korea. Methods In the 10-year period from 1999~2009, we reviewed 59 patients with onychomycosis due to NDM. The etiologic agents were identified by cultures on Sabouraud's Dextrose agar with and without cycloheximide. In some cases, internal transcribed spacer sequence analysis was done. NDM isolated considered pathogens when the presence of fungal elements was identified by direct microscopy observation and in follow-up cultures yielding the same fungi. Results Onychomycosis due to NDM comprised 2.3% of all onychomycosis. Of the 59 patients with onychomycosis due to NDM, 84.7% were toenail onychomycosis and 15.3% were fingernail onychomycosis. The incidence rate was highest in the fifth decade (27.1%). The ratio of male to female patients was 1:1.6. The frequency of associated diseases, in descending order, was hypertension, diabetes mellitus, and cerebral hematoma. Distal and lateral subungual onychomycosis (86.4%) was the most common clinical type of onychomycosis. Aspergillus spp. was the most frequently isolated etiologic agent of onychomycosis due to NDM (83.0%). Other causative agents were Scopulariopsis brevicaulis (10.2%), Acremonium spp. (3.4%), Fusarium solani (1.7%), and Chaetomium globosum (1.7%). Conclusion Because of the increase in onychomycosis due to NDM, we suggest the need of a careful mycological examination in patients with onychomycosis. PMID:22577268

  17. Induced Background in the Mars Observer Gamma-Ray Spectrometer

    NASA Technical Reports Server (NTRS)

    Boynton, William V.; Evans, Larry G.; Starr, Richard; Bruekner, Johnnes; Bailey, S. H.; Trombka, Jacob I.

    1997-01-01

    Gamma-Ray Spectrometers in space must necessarily work in an environment of a background of lines due to natural and cosmic-ray induced radioactivity and lines due to prompt emission following nuclear reactions caused by primary and secondary cosmic rays. The Gamma-Ray Spectrometer (GRS) on the Mar Observer mission has provided important data allowing one to estimate for future missions the extent of the background due to cosmic rays. These data will help in the design of instruments and in calculation of realistic background intensities that may effect the sensitivity of determining the intensity of lines of interest.

  18. Induced Background in the Mars Observer Gamma-Ray Spectrometer

    NASA Astrophysics Data System (ADS)

    Boynton, W. V.; Evans, L. G.; Starr, R.; Brückner, J.; Bailey, S. H.; Trombka, J. I.

    Gamma-Ray Spectrometers in space must necessarily work in an environment of a background of lines due to natural and cosmic-ray induced radioactivity and lines due to prompt emission following nuclear reactions caused by primary and secondary cosmic rays. The Gamma-Ray Spectrometer (GRS) on the Mar Observer mission has provided important data allowing one to estimate for future missions the extent of the background due to cosmic rays. These data will help in the design of instruments and in calculation of realistic background intensities that may effect the sensitivity of determining the intensity of lines of interest.

  19. Greater need for background checks.

    PubMed

    Fiesta, J

    1999-11-01

    The push is on for a more uniform system of background checks for health care employees. Studies and crimes against patients have prompted regulation by the Health Care Financing Administration (HCFA), state governments, hospitals, and Congress.

  20. Millimeter wave polarimetric background measurements

    NASA Astrophysics Data System (ADS)

    Wallace, H. B.; McGee, R. A.

    1985-10-01

    Millimeter wave sensor research over the past years has been directed toward the development of a feature space for targets and background that is disjoint over a broad range of parameters. The results have been mixed at best. The BRL program is directed toward the investigation of the polarization and frequency characteristics of various types of background. The data would be collected so as to provide both systems engineers and systems analysts a useful and general set of millimeter wave background maps for development of performance estimates of current and proposed weapon systems. This paper highlights some of the key features of the instrumentation and measurement parameters which the authors believe to be important in establishing the polarization and frequency characteristics of both benign and hostile terrain backgrounds.

  1. Analysis of the XRS background

    NASA Technical Reports Server (NTRS)

    Kilbourne, Caroline A.; Boyce, K. R.; Brown, G. V.; Cottam, J.; Fujimoto, R.; Furusho, T.; Ishisaki, Y.; Kelley, R. L.; McCammon, D.; Mitsuda, K.

    2005-01-01

    Background counts on the XRS Calorimeter spectrometer of Astro-E2 have several sources, including primary cosmic rays and secondary particles interacting with the pixels and with the silicon structure of the array. After rejecting events coincident between pixels or between a pixel and the anti-coincidence detector behind the calorimeter array, the residual background on the ground in the 0.1 - 10 keV band is 1e-3 counts/s (8e-3 counts/s/sq cm). We will present the details of the ground background events and the rejection criteria required lo remove them while minimizing deadtime. We will also present preliminary analysis of the in-orbit background.

  2. Low Background Counting at LBNL

    NASA Astrophysics Data System (ADS)

    Smith, A. R.; Thomas, K. J.; Norman, E. B.; Chan, Y. D.; Lesko, K. T.; Hurley, D. L.

    The Low Background Facility (LBF) at Lawrence Berkeley National Laboratory in Berkeley, California provides low background gamma spectroscopy services to a wide array of experiments and projects. The analysis of samples takes place within two unique facilities; locally within a carefully-constructed, low background cave and remotely at an underground location that historically has operated underground in Oroville, CA, but has recently been relocated to the Sanford Underground Research Facility (SURF) in Lead, SD. These facilities provide a variety of gamma spectroscopy services to low background experiments primarily in the form of passive material screening for primordial radioisotopes (U, Th, K) or common cosmogenic/anthropogenic products, as well as active screening via Neutron Activation Analysis for specific applications. The LBF also provides hosting services for general R&D testing in low background environments on the surface or underground for background testing of detector systems or similar prototyping. A general overview of the facilities, services, and sensitivities is presented. Recent activities and upgrades will also be presented, such as the completion of a 3π anticoincidence shield at the surface station and environmental monitoring of Fukushima fallout. The LBF is open to any users for counting services or collaboration on a wide variety of experiments and projects.

  3. Low Background Counting at LBNL

    DOE PAGES

    Smith, A. R.; Thomas, K. J.; Norman, E. B.; ...

    2015-03-24

    The Low Background Facility (LBF) at Lawrence Berkeley National Laboratory in Berkeley, California provides low background gamma spectroscopy services to a wide array of experiments and projects. The analysis of samples takes place within two unique facilities; locally within a carefully-constructed, low background cave and remotely at an underground location that historically has operated underground in Oroville, CA, but has recently been relocated to the Sanford Underground Research Facility (SURF) in Lead, SD. These facilities provide a variety of gamma spectroscopy services to low background experiments primarily in the form of passive material screening for primordial radioisotopes (U, Th, K)more » or common cosmogenic/anthropogenic products, as well as active screening via Neutron Activation Analysis for specific applications. The LBF also provides hosting services for general R&D testing in low background environments on the surface or underground for background testing of detector systems or similar prototyping. A general overview of the facilities, services, and sensitivities is presented. Recent activities and upgrades will also be presented, such as the completion of a 3π anticoincidence shield at the surface station and environmental monitoring of Fukushima fallout. The LBF is open to any users for counting services or collaboration on a wide variety of experiments and projects.« less

  4. Low Background Counting at LBNL

    SciTech Connect

    Smith, A. R.; Thomas, K. J.; Norman, E. B.; Chan, Y. D.; Lesko, K. T.; Hurley, D. L.

    2015-03-24

    The Low Background Facility (LBF) at Lawrence Berkeley National Laboratory in Berkeley, California provides low background gamma spectroscopy services to a wide array of experiments and projects. The analysis of samples takes place within two unique facilities; locally within a carefully-constructed, low background cave and remotely at an underground location that historically has operated underground in Oroville, CA, but has recently been relocated to the Sanford Underground Research Facility (SURF) in Lead, SD. These facilities provide a variety of gamma spectroscopy services to low background experiments primarily in the form of passive material screening for primordial radioisotopes (U, Th, K) or common cosmogenic/anthropogenic products, as well as active screening via Neutron Activation Analysis for specific applications. The LBF also provides hosting services for general R&D testing in low background environments on the surface or underground for background testing of detector systems or similar prototyping. A general overview of the facilities, services, and sensitivities is presented. Recent activities and upgrades will also be presented, such as the completion of a 3π anticoincidence shield at the surface station and environmental monitoring of Fukushima fallout. The LBF is open to any users for counting services or collaboration on a wide variety of experiments and projects.

  5. Does your gene need a background check? How genetic background impacts the analysis of mutations, genes, and evolution.

    PubMed

    Chandler, Christopher H; Chari, Sudarshan; Dworkin, Ian

    2013-06-01

    The premise of genetic analysis is that a causal link exists between phenotypic and allelic variation. However, it has long been documented that mutant phenotypes are not a simple result of a single DNA lesion, but are instead due to interactions of the focal allele with other genes and the environment. Although an experimentally rigorous approach focused on individual mutations and isogenic control strains has facilitated amazing progress within genetics and related fields, a glimpse back suggests that a vast complexity has been omitted from our current understanding of allelic effects. Armed with traditional genetic analyses and the foundational knowledge they have provided, we argue that the time and tools are ripe to return to the underexplored aspects of gene function and embrace the context-dependent nature of genetic effects. We assert that a broad understanding of genetic effects and the evolutionary dynamics of alleles requires identifying how mutational outcomes depend upon the 'wild type' genetic background. Furthermore, we discuss how best to exploit genetic background effects to broaden genetic research programs.

  6. Background Tsunamis off the coast of Japan

    NASA Astrophysics Data System (ADS)

    Watada, S.

    2016-12-01

    JMA has been monitoring tsunamis at the outer rise of the Japan trench in real time since 2012 by using three DART stations separated about 100 km apart. Continuous tsunami data from Bottom Pressure Recorders (BPR) have been recovered and investigated for the background tsunamis, or long period surface gravity waves. Cross-correlation of two-hour-long records from two stations were computed and stacked for every month in 1.5 years. Each month, the cross-correlated ocean bottom pressure records starts with 1mm amplitude at zero time lag, indicating background tsunami wavelength can be as long as 200 km. The cross-correlation amplitude gradually increases up to 2mm at a time lag corresponding to the arrival time of the surface gravity waves with sharp pressure decrease due to the ocean depth. The wave period at the amplitude maximum is about 400 sec independent from station distance. Dispersed surface gravity waves follow after the amplitude peak. Seasonal variation of the amplitude the background tsunami is not clear, i.e., at one pair shows a larger amplitude in summer season by about 20% but other pairs do not. To look at the background tsunami propagation of longer distance, cross-correlations between DART 21413 (ESE Tokyo) and 21418 (NE Tokyo) have been computed operated by NOAA. Two stations are separated about 900 km. A one-year stack of the one-day-long cross-correlated records enhances weaker background tsunami waveforms with similar features but with a much smaller amplitude at zero time lag, indicating that background tsunami wavelength is smaller than 900km The merit of cross-correlation analysis of continuously recorded tsunamis is that the tsunami propagation can be obtained by the cross-correlation of observed data without a tsunami simulation.

  7. Estimation of orbital Doppler shift change due to nutation of attitude for 2-μm coherent Doppler lidar on ISS-JEM (International Space Station-Japanese Experimental Module)

    NASA Astrophysics Data System (ADS)

    Totsuka, Makoto; Asai, Kazuhiro; Iwasaki, Toshiki; Mizutani, Kohei; Itabe, Toshikasu

    2001-02-01

    Coherent Doppler Lidar (CDL), which has a capability of 3-D wind velocity measurements, can realize a global measurement of the wind profile in the troposphere from space. ISS(International Space Station) has been constructing from last year, and JEM(Japanese Experimental Module) attached to ISS is scheduled to be provided as a laboratory in space. We have been making a feasibility study for ISS-JEM/2-micrometer CDL. We expect that the ISS might give some technical problems because of a large scale and a man attended station. On the other hand, a measurement accuracy of 1m/s is required from the atmospheric science. We have to analyze the systematic error with considering the error factors to meet this requirement. There are two factors of the wind measurement errors caused by the nutation of ISS?fs attitude. One of them is a change of receiving power, since it should change distances between CDL and a observing point. In this case, we have already shown that the wind error estimated was only ?}0.05m/s (assumed width of pitching angle ;?}3deg). The other factor is a change of orbital Doppler shift. The accuracy of 1m/s is corresopnding to 1MHz. We calculated a frequency of orbital Doppler shift in case of non conical scanning one when ISS has the nutation of attitude with ?}3deg,as a pitching angle and a rolling angle,respectively. The results obtained in this syudy are very useful to design a frequency agile CW laser as a local oscillator.In this paper, we describe more details for our analysis.

  8. The Cosmic Microwave Background and its Polarization

    NASA Astrophysics Data System (ADS)

    Wollack, Edward

    2017-01-01

    The subtle spatial variations in the cosmic microwave background (CMB) radiation provide a unique astrophysical probe of the early Universe. Characterization of this relic radiation and its polarization have the power to reveal and constrain the properties of light astroparticle species, long wave gravitational radiation, and intervening mass concentrations. Recent advances in theory, observation, and instrumentation have set the stage to experimentally confront the inflationary paradigm via precision polarimetric surveys of the CMB. Current and proposed future observational efforts from the ground, balloon, and spaceborne platforms will be briefly surveyed in this presentation. Recent community activities by the Inflation Probe Science Interest Group (IPSIG) will also be presented.

  9. Thermal neutron background measurement in CJPL

    NASA Astrophysics Data System (ADS)

    Zeng, Z. M.; Gong, H.; Yue, Q.; Li, J. M.

    2015-12-01

    This paper describes the measurement of thermal neutron flux in the CJPL underground laboratory in the proximity of the CDEX experiment. A low background thermal neutron detection system is designed which applies a combination of a 3He proportional tube and a 4He proportional tube as the detector. Thermal neutrons can be captured by the 3He proportional tube while the 4He proportional tube is for the purpose of background measurement. The tube wall is made up of oxygen-free copper to reduce the background due to radioactivity of the wall material. The electronics readout system has been developed to store triggered events' waveforms so as to get the amplitude spectrum and monitor the data quality. We observed an average thermal neutron flux of Φ = 4.00 ± 0.08 ×10-6 /cm2 s in the CJPL experiment hall in the proximity of CDEX experiment and the neutron and background events both distribute uniformly along the tube.

  10. Can one measure the Cosmic Neutrino Background?

    NASA Astrophysics Data System (ADS)

    Faessler, Amand; Hodák, Rastislav; Kovalenko, Sergey; Šimkovic, Fedor

    The Cosmic Microwave Background (CMB) yields information about our Universe at around 380,000 years after the Big Bang (BB). Due to the weak interaction of the neutrinos with matter, the Cosmic Neutrino Background (CNB) should give information about a much earlier time of our Universe, around one second after the BB. Probably, the most promising method to "see" the CNB is the capture of the electron neutrinos from the Background by Tritium, which then decays into 3He and an electron with the energy of the the Q-value = 18.562 keV plus the electron neutrino rest mass. The "KArlsruhe TRItium Neutrino" (KATRIN) experiment, which is in preparation, seems presently the most sensitive proposed method for measuring the electron antineutrino mass. At the same time, KATRIN can also look by the reaction νe(˜1.95K) + 3H → 3He + e-(Q = 18.6keV + mνec2). The capture of the Cosmic Background Neutrinos (CNB) should show in the electron spectrum as a peak by the electron neutrino rest mass above Q. Here, the possibility to see the CNB with KATRIN is studied. A detection of the CNB by KATRIN seems not to be possible at the moment. But KATRIN should be able to determine an upper limit for the local electron neutrino density of the CNB.

  11. Can one measure the Cosmic Neutrino Background?

    NASA Astrophysics Data System (ADS)

    Faessler, Amand; Hodák, Rastislav; Kovalenko, Sergey; Šimkovic, Fedor

    The Cosmic Microwave Background (CMB) yields information about our Universe at around 380,000 years after the Big Bang (BB). Due to the weak interaction of the neutrinos with matter, the Cosmic Neutrino Background (CNB) should give information about a much earlier time of our Universe, around one second after the BB. Probably, the most promising method to “see” the CNB is the capture of the electron neutrinos from the Background by Tritium, which then decays into 3He and an electron with the energy of the the Q-value = 18.562keV plus the electron neutrino rest mass. The “KArlsruhe TRItium Neutrino” (KATRIN) experiment, which is in preparation, seems presently the most sensitive proposed method for measuring the electron antineutrino mass. At the same time, KATRIN can also look by the reaction νe(˜ 1.95K) +3H →3He + e‑(Q = 18.6keV + m νec2). The capture of the Cosmic Background Neutrinos (CNB) should show in the electron spectrum as a peak by the electron neutrino rest mass above Q. Here, the possibility to see the CNB with KATRIN is studied. A detection of the CNB by KATRIN seems not to be possible at the moment. But KATRIN should be able to determine an upper limit for the local electron neutrino density of the CNB.

  12. The disease-modifying effects of a Sativex-like combination of phytocannabinoids in mice with experimental autoimmune encephalomyelitis are preferentially due to Δ9-tetrahydrocannabinol acting through CB1 receptors.

    PubMed

    Moreno-Martet, Miguel; Feliú, Ana; Espejo-Porras, Francisco; Mecha, Miriam; Carrillo-Salinas, Francisco J; Fernández-Ruiz, Javier; Guaza, Carmen; de Lago, Eva

    2015-11-01

    Sativex(®), an equimolecular combination of Δ(9)-tetrahydrocannabinol-botanical drug substance (Δ(9)-THC-BDS) and cannabidiol-botanical drug substance (CBD-BDS), is a licensed medicine that may be prescribed for alleviating specific symptoms of multiple sclerosis (MS) such as spasticity and pain. However, further evidence suggest that it could be also active as disease-modifying therapy given the immunomodulatory, anti-inflammatory and cytoprotective properties of their two major components. In this study, we investigated this potential in the experimental autoimmune encephalitis (EAE) model of MS in mice. We compared the effect of a Sativex-like combination of Δ(9)-THC-BDS (10 mg/kg) and CBD-BDS (10 mg/kg) with Δ(9)-THC-BDS (20 mg/kg) or CBD-BDS (20 mg/kg) administered separately by intraperitoneal administration to EAE mice. Treatments were initiated at the time that symptoms appear and continued up to the first relapse of the disease. The results show that the treatment with a Sativex-like combination significantly improved the neurological deficits typical of EAE mice, in parallel with a reduction in the number and extent of cell aggregates present in the spinal cord which derived from cell infiltration to the CNS. These effects were completely reproduced by the treatment with Δ(9)-THC-BDS alone, but not by CBD-BDS alone which only delayed the onset of the disease without improving disease progression and reducing the cell infiltrates in the spinal cord. Next, we investigated the potential targets involved in the effects of Δ(9)-THC-BDS by selectively blocking CB(1) or PPAR-γ receptors, and we found a complete reversion of neurological benefits and the reduction in cell aggregates only with rimonabant, a selective CB(1) receptor antagonist. Collectively, our data support the therapeutic potential of Sativex as a phytocannabinoid formulation capable of attenuating EAE progression, and that the active compound was Δ(9)-THC-BDS acting through CB(1

  13. Gravitino condensation in fivebrane backgrounds

    NASA Astrophysics Data System (ADS)

    Kitazawa, Noriaki

    2002-04-01

    We calculate the tension of the D3-brane in the fivebrane background which is described by the exactly solvable SU(2)k×U(1) world-sheet conformal field theory with large Kač-Moody level k. The D3-brane tension is extracted from the amplitude of one closed string exchange between two parallel D3-branes, and the amplitude is calculated by utilizing the open-closed string duality. The tension of the D3-brane in the background does not coincide with the one in the flat space-time even in the flat space-time limit: k-->∞. The finite curvature effect should vanish in the flat space-time limit and only the topological effect can remain. Therefore, the deviation suggests the condensation of the gravitino and/or dilatino which has been expected in the fivebrane background as a gravitational instanton.

  14. Robust background modelling in DIALS

    PubMed Central

    Parkhurst, James M.; Winter, Graeme; Waterman, David G.; Fuentes-Montero, Luis; Gildea, Richard J.; Murshudov, Garib N.; Evans, Gwyndaf

    2016-01-01

    A method for estimating the background under each reflection during integration that is robust in the presence of pixel outliers is presented. The method uses a generalized linear model approach that is more appropriate for use with Poisson distributed data than traditional approaches to pixel outlier handling in integration programs. The algorithm is most applicable to data with a very low background level where assumptions of a normal distribution are no longer valid as an approximation to the Poisson distribution. It is shown that traditional methods can result in the systematic underestimation of background values. This then results in the reflection intensities being overestimated and gives rise to a change in the overall distribution of reflection intensities in a dataset such that too few weak reflections appear to be recorded. Statistical tests performed during data reduction may mistakenly attribute this to merohedral twinning in the crystal. Application of the robust generalized linear model algorithm is shown to correct for this bias. PMID:27980508

  15. Ion Beam Scattering by Background Helium

    NASA Astrophysics Data System (ADS)

    Grillet, Anne; Hughes, Thomas; Boerner, Jeremiah

    2015-11-01

    The presence of background gases can cause charged particle beams to become more diffuse due to scattering. Calculations for the transport of an ion beam have been performed using Aleph, a particle-in-cell plasma modeling code, and verified against a general envelop equation for charged particle beams. We have investigated the influence of background helium on the coherence and transmitted current of the ion beam. Collisions between ions and neutral particles were calculated assuming isotropic elastic scattering. Since this tends to predict larger scattering angles than are expected at high energies, these are conservative estimates for beam scattering. Sandia National Laboratories is a multi-program laboratory managed and operated by Sandia Corporation, a wholly owned subsidiary of Lockheed Martin Corporation, for the U.S. Department of Energy's National Nuclear Security Administration.

  16. Background music and cognitive performance.

    PubMed

    Angel, Leslie A; Polzella, Donald J; Elvers, Greg C

    2010-06-01

    The present experiment employed standardized test batteries to assess the effects of fast-tempo music on cognitive performance among 56 male and female university students. A linguistic processing task and a spatial processing task were selected from the Criterion Task Set developed to assess verbal and nonverbal performance. Ten excerpts from Mozart's music matched for tempo were selected. Background music increased the speed of spatial processing and the accuracy of linguistic processing. The findings suggest that background music can have predictable effects on cognitive performance.

  17. Detector Background at Muon Colliders

    SciTech Connect

    Mokhov, N.V.; Striganov, S.I.; /Fermilab

    2011-09-01

    Physics goals of a Muon Collider (MC) can only be reached with appropriate design of the ring, interaction region (IR), high-field superconducting magnets, machine-detector interface (MDI) and detector. Results of the most recent realistic simulation studies are presented for a 1.5-TeV MC. It is shown that appropriately designed IR and MDI with sophisticated shielding in the detector have a potential to substantially suppress the background rates in the MC detector. The main characteristics of backgrounds are studied.

  18. Exotic branes and nongeometric backgrounds.

    PubMed

    de Boer, Jan; Shigemori, Masaki

    2010-06-25

    When string or M theory is compactified to lower dimensions, the U-duality symmetry predicts so-called exotic branes whose higher-dimensional origin cannot be explained by the standard string or M-theory branes. We argue that exotic branes can be understood in higher dimensions as nongeometric backgrounds or U folds, and that they are important for the physics of systems which originally contain no exotic charges, since the supertube effect generically produces such exotic charges. We discuss the implications of exotic backgrounds for black hole microstate (non-)geometries.

  19. Generative electronic background music system

    SciTech Connect

    Mazurowski, Lukasz

    2015-03-10

    In this short paper-extended abstract the new approach to generation of electronic background music has been presented. The Generative Electronic Background Music System (GEBMS) has been located between other related approaches within the musical algorithm positioning framework proposed by Woller et al. The music composition process is performed by a number of mini-models parameterized by further described properties. The mini-models generate fragments of musical patterns used in output composition. Musical pattern and output generation are controlled by container for the mini-models - a host-model. General mechanism has been presented including the example of the synthesized output compositions.

  20. Removal of nonresonant background in MCARS spectra using Fourier filtering

    NASA Astrophysics Data System (ADS)

    Roberson, Stephen D.; Pellegrino, Paul M.

    2015-05-01

    Multiplex coherent anti-Stokes Raman spectroscopy (MCARS) has been used to create a complete Raman spectrum of a material of interest in milliseconds. However, these MCARS spectra often embedded in a nonresonant background that reduces the ability to use those spectra to positively identify the material of interest. There are a number of techniques that are used experimentally to reduce the nonresonant background when taking the MCARS spectrum. However, there are situations where these experimental nonresonant background reduction techniques may result in a loss of the desired MCARS signal. In an effort to maintain the signal strength of the MCARS spectrum, analytical methods of background removal are employed. There are a number of analytical techniques for nonresonant background removal from MCARS signals. However, many of them either make blanket assumptions about the nonresonant background that sacrifice accuracy of the technique or require knowledge of the material of interest before removing the nonresonant background. We will be reporting on an analytical method to remove the nonresonant background that utilizes a combination of the maximum entropy method to reproduce the spectrum as well as complex spectral filtering to remove the nonresonant background and accurately determine the CARS spectrum interest without prior knowledge of the material of interest.

  1. Educational Choice. A Background Paper.

    ERIC Educational Resources Information Center

    Quality Education for Minorities Network, Washington, DC.

    This paper addresses school choice, one proposal to address parental involvement concerns, focusing on historical background, definitions, rationale for advocating choice, implementation strategies, and implications for minorities and low-income families. In the past, transfer payment programs such as tuition tax credits and vouchers were…

  2. A Little Background Music, Please.

    ERIC Educational Resources Information Center

    Giles, Martha Mead

    1991-01-01

    Background music could be used to provide a pleasant beginning for the school day, to help keep students quiet and relaxed in the school cafeteria at lunchtime, and to provide a midafternoon lift for bored and tired children. The most effective music pleases children without overly exciting them through jarring rhythms and loud dynamics. (nine…

  3. Cultural Change. Teacher Background Material.

    ERIC Educational Resources Information Center

    Georgia Univ., Athens. Anthropology Curriculum Project.

    This essay on cultural change is intended to provide background reading material for teachers using "The Changing World Today" or "Cultural Change in Mexico and the United States," two textbooks from the Anthropology Curriculum Project. The essay can also be used, however, as a high school semester course in anthropology or as…

  4. Teaching about Natural Background Radiation

    ERIC Educational Resources Information Center

    Al-Azmi, Darwish; Karunakara, N.; Mustapha, Amidu O.

    2013-01-01

    Ambient gamma dose rates in air were measured at different locations (indoors and outdoors) to demonstrate the ubiquitous nature of natural background radiation in the environment and to show that levels vary from one location to another, depending on the underlying geology. The effect of a lead shield on a gamma radiation field was also…

  5. Teaching about Natural Background Radiation

    ERIC Educational Resources Information Center

    Al-Azmi, Darwish; Karunakara, N.; Mustapha, Amidu O.

    2013-01-01

    Ambient gamma dose rates in air were measured at different locations (indoors and outdoors) to demonstrate the ubiquitous nature of natural background radiation in the environment and to show that levels vary from one location to another, depending on the underlying geology. The effect of a lead shield on a gamma radiation field was also…

  6. Regional Background Fine Particulate Matter

    EPA Science Inventory

    A modeling system composed of the global model GEOS-Chem providing hourly lateral boundary conditions to the regional model CMAQ was used to calculate the policy relevant background level of fine particulate: matter. Simulations were performed for the full year of 2004 over the d...

  7. Low background techniques in CANDLES

    SciTech Connect

    Nakajima, K. E-mail: nkyohei@u-fukui.ac.jp; Iida, T.; Matsuoka, K.; Nomachi, M.; Umehara, S.; Kishimoto, T.; Chan, W. M.; Kakubata, H.; Li, X.; Maeda, T.; Ohata, T.; Temuge, B.; Tetsuno, K.; Trang, V. T. T.; Uehara, T.; Yoshida, S.; Morishita, K.; Ogawa, I.; Sakamoto, K.; Tamagawa, Y.; and others

    2015-08-17

    CANDLES is a double beta decay experiment using {sup 48}Ca in CaF{sub 2} crystals. The measurement is being performed with prototype detector (CANDLES III) for high sensitive measurement in the future. Recent status of detector improvements and background reduction techniques are described in this paper.

  8. Teacher Pensions: A Background Paper

    ERIC Educational Resources Information Center

    Hansen, Janet S.

    2008-01-01

    Pensions are an important but comparatively unexamined component of human resource policies in education. In an increasingly competitive world where employees are more mobile than ever, pension policies that were designed in the last century may be out of step with the needs of both individuals and schools. This background paper aims to foster…

  9. Low background techniques in CANDLES

    NASA Astrophysics Data System (ADS)

    Nakajima, K.; Iida, T.; Kishimoto, T.; Matsuoka, K.; Nomachi, M.; Umehara, S.; Chan, W. M.; Kakubata, H.; Li, X.; Maeda, T.; Ohata, T.; Temuge, B.; Tetsuno, K.; Trang, V. T. T.; Uehara, T.; Yoshida, S.; Morishita, K.; Ogawa, I.; Sakamoto, K.; Tamagawa, Y.; Yoshizawa, M.; Fushimi, K.; Hazama, R.; Naktani, N.; Suzuki, K.

    2015-08-01

    CANDLES is a double beta decay experiment using 48Ca in CaF2 crystals. The measurement is being performed with prototype detector (CANDLES III) for high sensitive measurement in the future. Recent status of detector improvements and background reduction techniques are described in this paper.

  10. Ambient background particulate composition, outdoor natural background: interferents/clutter

    NASA Astrophysics Data System (ADS)

    Paterno, Dorothea

    2012-06-01

    It has proven a very difficult task to discriminate an actual BW threat from the natural occurring ambient particulate aerosol, which includes a significant fraction of particles consisting of mixed mineral and biological material. The interferent particles [clutter] (bio and non bio) concentration varies widely both by location, weather and season and diurnally. Naturally occurring background particulates are composed of fungal and bacterial spores both fragments and components, plant fragments and debris, animal fragments and debris, all of which may be associated with inert dust or combustion material. Some or all of which could also be considered to be an interferent to a biological warfare detector and cause these biodector systems to cause False Alarms by non specific BW bio detectors. I will share analysis of current long term background data sets.

  11. Muon background studies for shallow depth Double - Chooz near detector

    SciTech Connect

    Gómez, H.

    2015-08-17

    Muon events are one of the main concerns regarding background in neutrino experiments. The placement of experimental set-ups in deep underground facilities reduce considerably their impact on the research of the expected signals. But in the cases where the detector is installed on surface or at shallow depth, muon flux remains high, being necessary their precise identification for further rejection. Total flux, mean energy or angular distributions are some of the parameters that can help to characterize the muons. Empirically, the muon rate can be measured in an experiment by a number of methods. Nevertheless, the capability to determine the muons angular distribution strongly depends on the detector features, while the measurement of the muon energy is quite difficult. Also considering that on-site measurements can not be extrapolated to other sites due to the difference on the overburden and its profile, it is necessary to find an adequate solution to perform the muon characterization. The method described in this work to obtain the main features of the muons reaching the experimental set-up, is based on the muon transport simulation by the MUSIC software, combined with a dedicated sampling algorithm for shallow depth installations based on a modified Gaisser parametrization. This method provides all the required information about the muons for any shallow depth installation if the corresponding overburden profile is implemented. In this work, the method has been applied for the recently commissioned Double - Chooz near detector, which will allow the cross-check between the simulation and the experimental data, as it has been done for the far detector.

  12. Muon background studies for shallow depth Double - Chooz near detector

    NASA Astrophysics Data System (ADS)

    Gómez, H.

    2015-08-01

    Muon events are one of the main concerns regarding background in neutrino experiments. The placement of experimental set-ups in deep underground facilities reduce considerably their impact on the research of the expected signals. But in the cases where the detector is installed on surface or at shallow depth, muon flux remains high, being necessary their precise identification for further rejection. Total flux, mean energy or angular distributions are some of the parameters that can help to characterize the muons. Empirically, the muon rate can be measured in an experiment by a number of methods. Nevertheless, the capability to determine the muons angular distribution strongly depends on the detector features, while the measurement of the muon energy is quite difficult. Also considering that on-site measurements can not be extrapolated to other sites due to the difference on the overburden and its profile, it is necessary to find an adequate solution to perform the muon characterization. The method described in this work to obtain the main features of the muons reaching the experimental set-up, is based on the muon transport simulation by the MUSIC software, combined with a dedicated sampling algorithm for shallow depth installations based on a modified Gaisser parametrization. This method provides all the required information about the muons for any shallow depth installation if the corresponding overburden profile is implemented. In this work, the method has been applied for the recently commissioned Double - Chooz near detector, which will allow the cross-check between the simulation and the experimental data, as it has been done for the far detector.

  13. Background reduction in the SNO+ experiment

    SciTech Connect

    Segui, L.

    2015-08-17

    SNO+ is a large multi-purpose liquid scintillator experiment, which first aim is to detect the neutrinoless double beta decay of {sup 130}Te. It is placed at SNOLAB, at 6000 m.w.e. and it is based on the SNO infrastructure. SNO+ will contain approximately 780 tonnes of liquid scintillator, loaded with {sup 130}Te inside an acrylic vessel (AV) with an external volume of ultra pure water to reduce the external backgrounds. Light produced in the scintillator by the interaction of particles will be detected with about 9,000 photomultiplier’s. For the neutrinoless double beta decay phase, due to its the extremely low rate expected, the control, knowledge and reduction of the background is essential. Moreover, it will also benefit other phases of the experiment focused on the study of solar neutrinos, nucleon decay, geoneutrinos and supernovae. In order to reduce the internal background level, a novel purification technique for tellurium loaded scintillators has been developed by the collaboration that reduces the U/Th concentration and several cosmic-activated isotopes by at least a factor 10{sup 2} -10{sup 3} in a single pass. In addition, different rejection techniques have been developed for the remaining internal backgrounds based on Monte-Carlo simulations. In this work, the scintillator purification technique and the levels obtained with it will be discussed. Furthermore, an overview of the different backgrounds for the double-beta phase will be presented, highlighting some of the techniques developed to reject the remained decays based on their expected timing differences.

  14. The cosmic infrared background experiment

    NASA Astrophysics Data System (ADS)

    Bock, James; Battle, John; Cooray, Asantha; Kawada, Mitsunobu; Keating, Brian; Lange, Andrew; Lee, Dae-Hea; Matsumoto, Toshio; Matsuura, Shuji; Pak, Soojong; Renbarger, Tom; Sullivan, Ian; Tsumura, Kohji; Wada, Takehiko; Watabe, Toyoki

    2006-03-01

    The extragalactic background, based on absolute measurements reported by DIRBE and IRTS at 1.2 and 2.2 μm, exceeds the brightness derived from galaxy counts by up to a factor 5. Furthermore, both DIRBE and the IRTS report fluctuations in the near-infrared sky brightness that appear to have an extra-galactic origin, but are larger than expected from local ( z = 1-3) galaxies. These observations have led to speculation that a new class of high-mass stars or mini-quasars may dominate primordial star formation at high-redshift ( z ˜ 10-20), which, in order to explain the excess in the near-infrared background, must be highly luminous but produce a limited amount of metals and X-ray photons. Regardless of the nature of the sources, if a significant component of the near-infrared background comes from first-light galaxies, theoretical models generically predict a prominent near-infrared spectral feature from the redshifted Lyman cutoff, and a distinctive fluctuation power spectrum. We are developing a rocket-borne instrument (the Cosmic Infrared Background ExpeRiment, or CIBER) to search for signatures of primordial galaxy formation in the cosmic near-infrared extra-galactic background. CIBER consists of a wide-field two-color camera, a low-resolution absolute spectrometer, and a high-resolution narrow-band imaging spectrometer. The cameras will search for spatial fluctuations in the background on angular scales from 7″ to 2°, where a first-light galaxy signature is expected to peak, over a range of angular scales poorly covered by previous experiments. CIBER will determine if the fluctuations reported by the IRTS arise from first-light galaxies or have a local origin. In a short rocket flight CIBER has sensitivity to probe fluctuations 100× fainter than IRTS/DIRBE, with sufficient resolution to remove local-galaxy correlations. By jointly observing regions of the sky studied by Spitzer and ASTRO-F, CIBER will build a multi-color view of the near

  15. EXO-200 results and cosmogenic backgrounds

    NASA Astrophysics Data System (ADS)

    Belov, V. A.; EXO-200 collaboration

    2017-01-01

    Status update and recent results from the double beta decay search experiment EXO-200 are presented. Detector is a liquid xenon TPC with charge and light readout located underground in low-background laboratory at 1600 m.w.e. depth. It contains 175 kg of xenon with 80.6% abundance of 136Xe, which acts as both the decaying nucleus and detection medium. Detector showed good performance and achieved remarkable results. The detector has demonstrated excellent energy resolution and background rejection capabilities and has set a lower limit on the 0νββ-decay half-life of 1.1 × 1025 years at 90% C.L. in early 2014. The EXO-200 collaboration has since published several papers on experimental backgrounds and searches for rare or exotic processes. After a two-year data interruption, EXO-200 is now back online with significant hardware improvements, including a radon reduction air system and a front end electronics upgrade for better energy resolution.

  16. The Cosmic Infrared Background Experiment

    NASA Astrophysics Data System (ADS)

    Bock, James; Battle, J.; Cooray, A.; Hristov, V.; Kawada, M.; Keating, B.; Lee, D.; Matsumoto, T.; Matsuura, S.; Nam, U.; Renbarger, T.; Sullivan, I.; Tsumura, K.; Wada, T.; Zemcov, M.

    2009-01-01

    We are developing the Cosmic Infrared Background ExpeRiment (CIBER) to search for signatures of first-light galaxy emission in the extragalactic background. The first generation of stars produce characteristic signatures in the near-infrared extragalactic background, including a redshifted Ly-cutoff feature and a characteristic fluctuation power spectrum, that may be detectable with a specialized instrument. CIBER consists of two wide-field cameras to measure the fluctuation power spectrum, and a low-resolution and a narrow-band spectrometer to measure the absolute background. The cameras will search for fluctuations on angular scales from 7 arcseconds to 2 degrees, where the first-light galaxy spatial power spectrum peaks. The cameras have the necessary combination of sensitivity, wide field of view, spatial resolution, and multiple bands to make a definitive measurement. CIBER will determine if the fluctuations reported by Spitzer arise from first-light galaxies. The cameras observe in a single wide field of view, eliminating systematic errors associated with mosaicing. Two bands are chosen to maximize the first-light signal contrast, at 1.6 um near the expected spectral maximum, and at 1.0 um; the combination is a powerful discriminant against fluctuations arising from local sources. We will observe regions of the sky surveyed by Spitzer and Akari. The low-resolution spectrometer will search for the redshifted Lyman cutoff feature in the 0.7 - 1.8 um spectral region. The narrow-band spectrometer will measure the absolute Zodiacal brightness using the scattered 854.2 nm Ca II Fraunhofer line. The spectrometers will test if reports of a diffuse extragalactic background in the 1 - 2 um band continues into the optical, or is caused by an under estimation of the Zodiacal foreground. We report performance of the assembled and tested instrument as we prepare for a first sounding rocket flight in early 2009. CIBER is funded by the NASA/APRA sub-orbital program.

  17. Chiral pions in a magnetic background

    NASA Astrophysics Data System (ADS)

    Colucci, G.; Fraga, E. S.; Sedrakian, A.

    2014-01-01

    We investigate the modification of the pion self-energy at finite temperature due to its interaction with a low-density, isospin-symmetric nuclear medium embedded in a constant magnetic background. To one loop, for fixed temperature and density, we find that the pion effective mass increases with the magnetic field. For the π-, interestingly, this happens solely due to the trivial Landau quantization shift ∼|eB|, since the real part of the self-energy is negative in this case. In a scenario in which other charged particle species are present and undergo an analogous trivial shift, the relevant behavior of the effective mass might be determined essentially by the real part of the self-energy. In this case, we find that the pion mass decreases by ∼10% for a magnetic field |eB|∼mπ2, which favors pion condensation at high density and low temperatures.

  18. An Improved Spectral Background Subtraction Method Based on Wavelet Energy.

    PubMed

    Zhao, Fengkui; Wang, Jian; Wang, Aimin

    2016-12-01

    Most spectral background subtraction methods rely on the difference in frequency response of background compared with characteristic peaks. It is difficult to extract accurately the background components from the spectrum when characteristic peaks and background have overlaps in frequency domain. An improved background estimation algorithm based on iterative wavelet transform (IWT) is presented. The wavelet entropy principle is used to select the best wavelet basis. A criterion based on wavelet energy theory to determine the optimal iteration times is proposed. The case of energy dispersive X-ray spectroscopy is discussed for illustration. A simulated spectrum with a prior known background and an experimental spectrum are tested. The processing results of the simulated spectrum is compared with non-IWT and it demonstrates the superiority of the IWT. It has great significance to improve the accuracy for spectral analysis.

  19. Monte Carlo Simulations of Background Spectra in Integral Imager Detectors

    NASA Technical Reports Server (NTRS)

    Armstrong, T. W.; Colborn, B. L.; Dietz, K. L.; Ramsey, B. D.; Weisskopf, M. C.

    1998-01-01

    Predictions of the expected gamma-ray backgrounds in the ISGRI (CdTe) and PiCsIT (Csl) detectors on INTEGRAL due to cosmic-ray interactions and the diffuse gamma-ray background have been made using a coupled set of Monte Carlo radiation transport codes (HETC, FLUKA, EGS4, and MORSE) and a detailed, 3-D mass model of the spacecraft and detector assemblies. The simulations include both the prompt background component from induced hadronic and electromagnetic cascades and the delayed component due to emissions from induced radioactivity. Background spectra have been obtained with and without the use of active (BGO) shielding and charged particle rejection to evaluate the effectiveness of anticoincidence counting on background rejection.

  20. Monte Carlo Simulations of Background Spectra in Integral Imager Detectors

    NASA Technical Reports Server (NTRS)

    Armstrong, T. W.; Colborn, B. L.; Dietz, K. L.; Ramsey, B. D.; Weisskopf, M. C.

    1998-01-01

    Predictions of the expected gamma-ray backgrounds in the ISGRI (CdTe) and PiCsIT (Csl) detectors on INTEGRAL due to cosmic-ray interactions and the diffuse gamma-ray background have been made using a coupled set of Monte Carlo radiation transport codes (HETC, FLUKA, EGS4, and MORSE) and a detailed, 3-D mass model of the spacecraft and detector assemblies. The simulations include both the prompt background component from induced hadronic and electromagnetic cascades and the delayed component due to emissions from induced radioactivity. Background spectra have been obtained with and without the use of active (BGO) shielding and charged particle rejection to evaluate the effectiveness of anticoincidence counting on background rejection.

  1. WFC3/UVIS Sky Backgrounds

    NASA Astrophysics Data System (ADS)

    Baggett, Sylvia; Anderson, Jay

    2012-06-01

    This report summarizes the on-orbit background levels present in WFC3/UVIS full-frame images. The results are based on nearly all standard readout images taken since the installation of WFC3 on HST in May 2009, with a relatively small number of exclusions e.g. images with obvious anomalous backgrounds (such as extended targets filling the field of view) or those taken with the quad filters (different bandpass in each amp). Comparisons are provided to estimates from the Exposure Time Calculator (ETC). We anticipate these results to be helpful in fine-tuning the level of post-flash required to achieve the optimum balance of charge transfter efficiency (CTE) loss mitigation versus noise penalty. Observers considering the use of post-flash should refer to the White Paper (MacKenty & Smith 2012) on the CTE WWW page (http://www.stsci.edu/hst/wfc3/ins_performance/CTE/).

  2. Conductivity in an anisotropic background

    SciTech Connect

    Lee, Bum-Hoon; Nam, Siyoung; Pang, Da-Wei; Park, Chanyong

    2011-03-15

    By using the gauge/gravity duality, we investigate the dual field theories of the anisotropic backgrounds, which are exact solutions of Einstein-Maxwell-dilaton theory with a Liouville potential. When we turn on the bulk gauge field fluctuation A{sub x} with a nontrivial dilaton coupling, the AC conductivity of this dual field theory is proportional to the frequency with an exponent depending on parameters of the anisotropic background. In some parameter regions, we find that this conductivity can have the negative exponent like the strange metal. In addition, we also investigate another U(1) gauge field fluctuation, which is not coupled with a dilaton field. We classify all possible conductivities of this system and find that the exponent of the conductivity is always positive.

  3. Due process traditionalism.

    PubMed

    Sunstein, Cass R

    2008-06-01

    In important cases, the Supreme Court has limited the scope of "substantive due process" by reference to tradition, but it has yet to explain why it has done so. Due process traditionalism might be defended in several distinctive ways. The most ambitious defense draws on a set of ideas associated with Edmund Burke and Friedrich Hayek, who suggested that traditions have special credentials by virtue of their acceptance by many minds. But this defense runs into three problems. Those who have participated in a tradition may not have accepted any relevant proposition; they might suffer from a systematic bias; and they might have joined a cascade. An alternative defense sees due process traditionalism as a second-best substitute for two preferable alternatives: a purely procedural approach to the Due Process Clause, and an approach that gives legislatures the benefit of every reasonable doubt. But it is not clear that in these domains, the first-best approaches are especially attractive; and even if they are, the second-best may be an unacceptably crude substitute. The most plausible defense of due process traditionalism operates on rule-consequentialist grounds, with the suggestion that even if traditions are not great, they are often good, and judges do best if they defer to traditions rather than attempting to specify the content of "liberty" on their own. But the rule-consequentialist defense depends on controversial and probably false assumptions about the likely goodness of traditions and the institutional incapacities of judges.

  4. Tanzania: Background and Current Conditions

    DTIC Science & Technology

    2010-12-08

    in parliament. Tanzania continues its pattern of steady real Gross Domestic Product ( GDP ) growth and has a low and stable inflation rate. The...Economist Intelligence Unit predicts real Gross Domestic Product ( GDP ) growth of 7.1% in 2011 and 7.6% in 2012. Tanzania: Background and Current...unity for about 40 years in a region wracked by civil wars, often with ethnic dimensions, in neighboring Rwanda, Burundi , Uganda, the Democratic

  5. Rwanda: Background and Current Developments

    DTIC Science & Technology

    2010-12-07

    1994, the presidents of Rwanda and Burundi , along with several senior government officials, were killed when their plane was shot down as it...agreement in Tanzania, referred to as the Arusha Peace Accords. In April 1994, the presidents of Rwanda and Burundi , along with several senior government...Muslim: 4.6% GDP -Purchasing power parity: $10.13 billion (2009) GDP per capita: $900 (2009) Source: CIA—The World Factbook 2010. Rwanda: Background and

  6. The Cosmic Background Explorer /COBE/

    NASA Technical Reports Server (NTRS)

    Mather, J. C.

    1982-01-01

    The Cosmic Background Explorer (COBE) satellite, under study by NASA since 1976, will map the spectrum and the angular distribution of diffuse radiation from the universe over the entire wavelength range from 1 micron to 1.3 cm. It carries three instruments: a set of differential microwave radiometers (DMR) at 23.5, 31.4, 53, and 90GHz, a far infrared absolute spectrophotometer (FIRAS) covering 1 to 100 per cm, and a diffuse infrared background experiment (DIRBE) covering 1 to 300 microns. They will use the ideal space environment, a one year lifetime, and standard instrument techniques to achieve orders of magnitude improvements in sensitivity and accuracy, providing a fundamental data base for cosmology. The instruments are united by common purpose as well as similar environmental and orbital requirements. The data from all three experiments will be analyzed together, to distinguish nearby sources of radiation from the cosmologically interesting diffuse background radiations. Construction is planned to begin in 1982 for a launch in 1988.

  7. Background independence in a background dependent renormalization group

    NASA Astrophysics Data System (ADS)

    Labus, Peter; Morris, Tim R.; Slade, Zöe H.

    2016-07-01

    Within the derivative expansion of conformally reduced gravity, the modified split Ward identities are shown to be compatible with the flow equations if and only if either the anomalous dimension vanishes or the cutoff profile is chosen to have a power-law form. No solutions exist if the Ward identities are incompatible. In the compatible case, a clear reason is found for why Ward identities can still forbid the existence of fixed points; however, for any cutoff profile, a background independent (and parametrization independent) flow equation is uncovered. Finally, expanding in vertices, the combined equations are shown generically to become either overconstrained or highly redundant beyond the six-point level.

  8. Heterotic string in an arbitrary background field

    NASA Astrophysics Data System (ADS)

    Sen, Ashoke

    1985-10-01

    An expression for the light-cone gauge action for the first-quantized heterotic string in the presence of arbitrary background gauge, gravitational, and antisymmetric tensor fields is derived. The result is a two-dimensional local field theory with N=1/2 supersymmetry. The constraints imposed on the background fields in order to make this theory one-loop finite are derived. These constraints are identical to the equations of motion for the massless fields at the linearized level. Finally, it is shown that if there is no background antisymmetric tensor field, and if the gauge connection is set equal to the spin connection, the effective action is that of an N=1 supersymmetric nonlinear and N=2 supersymmetric Georgi-Glashow models the occurrence of the fermion fractionization is the necessity; the ignorance of it results in the inconsistency in the perturbative calculation of the mass splittings among the members of the supermultiplets. The notable feature of our result is that the degeneracy due to the Jackiw-Rebbi zero mode is not independent of the one required by the supersymmetry, suggesting a nontrivial structure in embedding the topology of Higgs fields into supersymmetric gauge theories.

  9. Experimental alcohol blastopathy.

    PubMed

    Sandor, S

    1988-01-01

    Experimental data are presented with respect to "experimental alcohol blastopathy" performed in our laboratory. As in our interpretation the notion of blastopathy involves both pathological changes during preimplantation development due to previous, preconceptional or preimplantation influences and later, pre- or postnatal effects induced by factors active during the preimplantation period, up to now the following experimental models were applied (on rats and mice): chronic and acute maternal, biparental or paternal ethanol alcoholization; preimplantation treatment with acetaldehyde or disulfiram followed by ethanol administration; acute ethanol intoxication before implantation on the background of chronic maternal ethanol intake; chronic maternal intake of various beverages. The main components of experimental alcohol blastopathy detected (by using a complex control methodology) were: pathological changes during the preimplantation developmental stages (lower mean number of embryos/animal, retardation of development, lowered migration rate of the embryos from the oviduct to the uterus, higher number of pathological morphological features), delayed implantation, disturbances of the early postimplantation development, retarded late foetal and placental growth. The effect of ethanol may be direct (ethanol being detectable in the oviductal and uterine fluid after both acute and chronic alcoholization) or indirect, via changes of the maternal macro- or microenvironment. The increase of the maternal blood acetaldehyde level may contribute to the appearance of alcohol blastopathy. Chronic beer and wine intake and acute intoxication with cognac suggest - up to now - the enhancing effect of beverage congeners. The noxious effect of acute ethanol intoxication superposed to chronic alcoholization is more marked that the separate effect of the two kinds of treatment. The chronic ethanol intake of fertilizing males (in mice) leads, both in the case of treated or untreated

  10. Entanglement generation due to the background electric field and curvature of space-time

    NASA Astrophysics Data System (ADS)

    Ebadi, Zahra; Mirza, Behrouz

    2015-02-01

    In Schwinger effect, quantum vacuum instability under the influence of an electric field leads to decay of vacuum into pairs of charged particles. We consider the entanglement of pair produced particles. We will show that the measure of entanglement depends on the geometry of space-time. Using the Schwinger pair production in curved space-time, dS2 and AdS2, we propose and demonstrate that the electric field can generate entanglement. In dS2 space-time, we study entanglement for scalar particles with zero spin in the absence and presence of a constant electric field. We show that the entanglement entropy depends on the choice of the α-vacua. But, for some values of the related parameters (mass, charge, scalar curvature, electric field), the entanglement entropy is independent of α. Also, we consider the generation of entanglement in the presence of a constant electric field for anti-de Sitter space-time. We will show that the positive (negative) curvature of space-time upgrades (degrades) the generated entanglement.

  11. An 8-Bit 600-MSps Flash ADC Using Interpolating and Background Self-Calibrating Techniques

    NASA Astrophysics Data System (ADS)

    Paik, Daehwa; Asada, Yusuke; Miyahara, Masaya; Matsuzawa, Akira

    This paper describes a flash ADC using interpolation (IP) and cyclic background self-calibrating techniques. The proposed IP technique that is cascade of capacitor IP and gate IP with dynamic double-tail latched comparator reduces non-linearity, power consumption, and occupied area. The cyclic background self-calibrating technique periodically suppresses offset mismatch voltages caused by static fluctuation and dynamic fluctuation due to temperature and supply voltage changes. The ADC has been fabricated in 90-nm 1P10M CMOS technology. Experimental results show that the ADC achieves SNDR of 6.07bits without calibration and 6.74bits with calibration up to 500MHz input signal at sampling rate of 600MSps. It dissipates 98.5mW on 1.2-V supply. FoM is 1.54pJ/conv.

  12. COS SMOV Calibration: Detector Background Performance

    NASA Astrophysics Data System (ADS)

    Ake, Thomas B., III; McPhate, J.; Osterman, S.; Sahnow, D.; Penton, S.; Keyes, C.; STScI COS Team; COS IDT Team

    2010-01-01

    The Cosmic Origins Spectrograph (COS), installed in May 2009 into the Hubble Space Telescope (HST), was designed with two low noise, photon counting detectors. The FUV channel utilizes a windowless, cross delay line (XDL) microchannel plate detector, with heritage from the Far Ultraviolet Spectroscopic Explorer (FUSE) mission. The NUV side employs a closed tube MAMA detector, which had been the Space Telescope Imaging Spectrograph (STIS) flight spare. The background performance of both channels was measured during the COS Servicing Mission Observatory Verification (SMOV) program. For the FUV detector, the background rate is as expected from prelaunch estimates, 2.4×10-6 counts/sec/pixel, except at times when HST is close to the South Atlantic Anomaly (SAA). Close to the SAA boundary, the rate can be as high as 8×10-5. Several weak structures are found in the dark exposures. Some of these are likely due to energetic particles trapped in the geomagnetic field and can be recognized by their large pulse heights. Others are low gain events. For TIME-TAG exposures, most features are removed in ground processing by pulse height filtering of the individual events. For ACCUM mode, which is only used for bright objects, suspect regions of the spectra will be marked by data quality flags, but the features are expected to be too weak to be of consequence. For the NUV detector, the background rate is 6.7×10-5 counts/sec/pixel, about three times lower than predicted from prelaunch estimates and about 15 times lower than the pre-Servicing Mission 4 performance of the STIS NUV detector. A difference in windows between the MAMAs accounts for much of the improvement. In particular, although the COS background is elevated near the SAA, up to 1×10-3 counts/sec/pixel, no long-term phosphorescence occurs in the window after HST passes through the SAA. Little structure is seen in the NUV darks.

  13. Teaching about natural background radiation

    NASA Astrophysics Data System (ADS)

    Al-Azmi, Darwish; Karunakara, N.; Mustapha, Amidu O.

    2013-07-01

    Ambient gamma dose rates in air were measured at different locations (indoors and outdoors) to demonstrate the ubiquitous nature of natural background radiation in the environment and to show that levels vary from one location to another, depending on the underlying geology. The effect of a lead shield on a gamma radiation field was also demonstrated to emphasize the important role of shielding in radiation protection. The measurements were carried out with a Geiger-Muller (GM)-based dosimeter and a NaI scintillation gamma-ray spectrometer, which are normally available in physics laboratories. Radioactivity in household materials was demonstrated using a gas mantle as an example.

  14. The Cosmic Background Explorer Satellite

    NASA Technical Reports Server (NTRS)

    Mather, J.; Kelsall, T.

    1980-01-01

    The Cosmic Background Explorer (COBE) satellite, planned for launch in 1985, will measure the diffuse infrared and microwave radiation of the universe over the entire wavelength range from a few microns to 1.3 cm. It will include three instruments: a set of microwave isotropy radiometers at 23, 31, 53, and 90 GHz, an interferometer spectrometer from 1 to 100/cm, and a filter photometer from 1 to 300 microns. The COBE satellite is designed to reach the sensitivity limits set by foreground sources such as the interstellar and interplanetary dust, starlight, and galactic synchrotron radiation, so that a diffuse residual radiation may be interpreted unambiguously as extragalactic

  15. 11C Background in Liquid Scintillator Detectors

    NASA Astrophysics Data System (ADS)

    Pocar, Andrea

    2005-09-01

    Cosmogenic 11C produced in muon showers is one of the main backgrounds for the detection of pep and CNO solar neutrinos in underground organic liquid scintillator detectors. Experimental data available for the effective cross section for 11C by muons indicate that 11C is in fact the dominant background for the observation of such neutrinos. 11C decays are expected to total a rate 2.5 (20) times higher than the combined rate of pep and CNO neutrinos in Borexino (KamLAND) in the energy window preferred for the pep measurement, between 0.8 and 1.3 MeV. Background from 11C in organic liquid scintillator detectors can be reduced if a neutron is emitted when the 11C nuclide is created. 11C decays can be tagged on a one-by-one basis using a three-fold coincidence with the parent muon track and the subsequent neutron capture on protons. The efficiency of such background reduction critically relies on the emission of a free neutron associated with 11C production. In order to verify the hypothesis, first suggested by Deutsch, that a neutron is in fact always emitted when 11C is produced, we perform a detailed ab initio calculation of the production of cosmogenic 11C, taking into consideration all relevant production channels. Results of the calculation are compared with the effective cross sections measured by target experiments in muon beams. "Bilnd" channels without a neutron in the final state account for only about 5% of 11C production modes. An estimation of the effectiveness of the one-by-one tagging of 11C events, in light of such "blind" channels is performed for KamLAND, Borexino, and a possible scintillator experiment at SNOLab. Both KamLAND and Borexino can significantly improve their pep and CNO solar neutrino signal and could perform a 3% mesurement of the pep solar neutrino flux in five years. At SNOLab depths the muon flux is low enough that 11C background would be much smaller than the pep and CNO neutrino signal and hence negligible.

  16. Detection prospects of the cosmic neutrino background

    NASA Astrophysics Data System (ADS)

    Li, Yu-Feng

    2015-04-01

    The existence of the cosmic neutrino background (CνB) is a fundamental prediction of the standard Big Bang cosmology. Although current cosmological probes provide indirect observational evidence, the direct detection of the CνB in a laboratory experiment is a great challenge to the present experimental techniques. We discuss the future prospects for the direct detection of the CνB, with the emphasis on the method of captures on beta-decaying nuclei and the PTOLEMY project. Other possibilities using the electron-capture (EC) decaying nuclei, the annihilation of extremely high-energy cosmic neutrinos (EHECνs) at the Z-resonance, and the atomic de-excitation method are also discussed in this review (talk given at the International Conference on Massive Neutrinos, Singapore, 9-13 February 2015).

  17. Detection Prospects of the Cosmic Neutrino Background

    NASA Astrophysics Data System (ADS)

    Li, Yu-Feng

    The existence of the cosmic neutrino background (CνB) is a fundamental prediction of the standard Big Bang cosmology. Although current cosmological probes provide indirect observational evidence, the direct detection of the CνB in a laboratory experiment is a great challenge to the present experimental techniques. We discuss the future prospects for the direct detection of the CνB, with the emphasis on the method of captures on beta-decaying nuclei and the PTOLEMY project. Other possibilities using the electron-capture (EC) decaying nuclei, the annihilation of extremely high-energy cosmic neutrinos (EHECνs) at the Z-resonance, and the atomic de-excitation method are also discussed in this review.

  18. FLUKA: Predictive power for cosmogenic backgrounds

    SciTech Connect

    Empl, A. Hungerford, E. V.; Ferrari, A.; Smirnov, G. I.

    2015-08-17

    The next generation of experiments searching for rare physics events with increased sensitivity will require precise predictions of cosmogenic backgrounds. Recent high quality deep underground measurements for cosmogenic neutrons in large liquid scintillator targets were used to study the FLUKA simulation package for this purpose. The results and conclusions drawn from a detailed benchmark comparison with data from the Borexino experiment were reported recently. In general, good agreement between data and simulation results were found with some identified discrepancies. Improved physics models already implemented in the current version of the FLUKA code, which will be publicly available with the upcoming code release, address the more important identified issues. A careful evaluation of the improved predictions is ongoing. However, the agreement between preliminary FLUKA simulation results and the Borexino experimental data are excellent. The preliminary findings will be discussed.

  19. Background-Oriented Schlieren Characterization of Explosions

    NASA Astrophysics Data System (ADS)

    Romo, Cynthia; Hargather, Michael

    2013-11-01

    Characterizing the energy release from large explosions is a difficult process using traditional point-pressure gages. The background oriented schlieren technique is used here to provide large-field-of-view visualization of the shock wave propagation from large-scale explosions. This technique is used to allow field-measurements of blast wave properties instead of traditional point-wise measurements. By analyzing the shock wave propagation Mach number the peak overpressure and overpressure duration are estimated for different explosions. The technique is applied to the visualization of encased explosions, including car bombs, to estimate the amount of shock energy lost to the fragmentation and acceleration of the casing. Comparisons are made to un-encased explosions. The optically measured data is compared to experimental data recorded using piezoelectric pressure transducers. Scaling relationships are examined to determine scalability of encased explosions.

  20. [Cosmic Microwave Background (CMB) Anisotropies

    NASA Technical Reports Server (NTRS)

    Silk, Joseph

    1998-01-01

    One of the main areas of research is the theory of cosmic microwave background (CMB) anisotropies and analysis of CMB data. Using the four year COBE data we were able to improve existing constraints on global shear and vorticity. We found that, in the flat case (which allows for greatest anisotropy), (omega/H)0 less than 10(exp -7), where omega is the vorticity and H is the Hubble constant. This is two orders of magnitude lower than the tightest, previous constraint. We have defined a new set of statistics which quantify the amount of non-Gaussianity in small field cosmic microwave background maps. By looking at the distribution of power around rings in Fourier space, and at the correlations between adjacent rings, one can identify non-Gaussian features which are masked by large scale Gaussian fluctuations. This may be particularly useful for identifying unresolved localized sources and line-like discontinuities. Levin and collaborators devised a method to determine the global geometry of the universe through observations of patterns in the hot and cold spots of the CMB. We have derived properties of the peaks (maxima) of the CMB anisotropies expected in flat and open CDM models. We represent results for angular resolutions ranging from 5 arcmin to 20 arcmin (antenna FWHM), scales that are relevant for the MAP and COBRA/SAMBA space missions and the ground-based interferometer. Results related to galaxy formation and evolution are also discussed.

  1. Human due diligence.

    PubMed

    Harding, David; Rouse, Ted

    2007-04-01

    Most companies do a thorough job of financial due diligence when they acquire other companies. But all too often, deal makers simply ignore or underestimate the significance of people issues in mergers and acquisitions. The consequences are severe. Most obviously, there's a high degree of talent loss after a deal's announcement. To make matters worse, differences in decision-making styles lead to infighting; integration stalls; and productivity declines. The good news is that human due diligence can help companies avoid these problems. Done early enough, it helps acquirers decide whether to embrace or kill a deal and determine the price they are willing to pay. It also lays the groundwork for smooth integration. When acquirers have done their homework, they can uncover capability gaps, points of friction, and differences in decision making. Even more important, they can make the critical "people" decisions-who stays, who goes, who runs the combined business, what to do with the rank and file-at the time the deal is announced or shortly thereafter. Making such decisions within the first 30 days is critical to the success of a deal. Hostile situations clearly make things more difficult, but companies can and must still do a certain amount of human due diligence to reduce the inevitable fallout from the acquisition process and smooth the integration. This article details the steps involved in conducting human due diligence. The approach is structured around answering five basic questions: Who is the cultural acquirer? What kind of organization do you want? Will the two cultures mesh? Who are the people you most want to retain? And how will rank-and-file employees react to the deal? Unless an acquiring company has answered these questions to its satisfaction, the acquisition it is making will be very likely to end badly.

  2. Formation of field-reversed ion rings in a magnetized background plasma

    SciTech Connect

    Omelchenko, Y.A.; Sudan, R.N.

    1995-07-01

    In typical field-reversed ion ring experiments, an intense annular ion beam is injected across a magnetic cusp into neutral gas immersed in a solenoidal magnetic field. In anticipation of a new experimental thrust to create strong field-reversed ion rings the beam evolution is investigated in a preformed background plasma on a time scale greater than an ion cyclotron period, using a new two and a half-dimensional (21/2-D) hybrid, particle-in-cell (PIC) code FIRE, in which the beam and background ions are treated as macro-particles and the electrons as a massless fluid. It is shown that under appropriate conditions axial beam bunching occurs in the downstream applied field and a compact field-reversed ring is formed. It is observed that the ring is reflected in a ramped magnetic field. Upon reflection its axial velocity is very much less than that expected from a single particle model due to the transfer of the mean axial momentum to the background ions. This increases the time available to apply a pulsed mirror for trapping the ring experimentally. {copyright} {ital 1995} {ital American} {ital Institute} {ital of} {ital Physics}.

  3. Decoherence due to Scattering Atoms

    NASA Astrophysics Data System (ADS)

    Uys, Hermann; Perreault, John; Cronin, Alex

    2004-05-01

    Coherent manipulation of a quantum system is difficult because of uncontrolled interactions with the system's environment. The study of decoherence so introduced is important for progress in quantum mechanical engineering, and for understanding the transition from quantum to classical behavior. We have observed loss of fringe contrast in a Mach-Zhender atom interferometer due to scattering background gas atoms and propose that this might be interpreted as quantum decoherence. Progress will be reported on the use of a general model of decoherence incorporating a semi-classical picture of atom scattering to explain the contrast loss [1]. A formal analogy is made to decoherence due to scattering photons from atoms in an interferometer [2]. [1] S.M. Tan, D.F. Waals, ``Loss of coherence in interferometry", Phys. Rev. A 47 p.4663 (1993) [2] D.A. Kokorowski, A.D. Cronin, T.D. Roberts, and D.E. Pritchard, ``From single- to multiple-photon decoherence in an atom interferometer", Phys. Rev. Lett. 86 p. 2191 (2001)

  4. Anomalous cosmic-microwave-background polarization and gravitational chirality.

    PubMed

    Contaldi, Carlo R; Magueijo, João; Smolin, Lee

    2008-10-03

    We consider the possibility that gravity breaks parity, with left and right-handed gravitons coupling to matter with a different Newton's constant and show that this would affect their zero-point vacuum fluctuations during inflation. Should there be a cosmic background of gravity waves, the effect would translate into anomalous cosmic microwave background polarization. Nonvanishing temperature-magnetic (TB) mode [and electric-magnetic mode] components emerge, revealing interesting experimental targets. Indeed, if reasonable chirality is present a TB measurement would provide the easiest way to detect a gravitational wave background. We speculate on the theoretical implications of such an observation.

  5. Electromagnetic polarizabilities: Lattice QCD in background fields

    SciTech Connect

    W. Detmold, B.C. Tiburzi, A. Walker-Loud

    2012-04-01

    Chiral perturbation theory makes definitive predictions for the extrinsic behavior of hadrons in external electric and magnetic fields. Near the chiral limit, the electric and magnetic polarizabilities of pions, kaons, and nucleons are determined in terms of a few well-known parameters. In this limit, hadrons become quantum mechanically diffuse as polarizabilities scale with the inverse square-root of the quark mass. In some cases, however, such predictions from chiral perturbation theory have not compared well with experimental data. Ultimately we must turn to first principles numerical simulations of QCD to determine properties of hadrons, and confront the predictions of chiral perturbation theory. To address the electromagnetic polarizabilities, we utilize the background field technique. Restricting our attention to calculations in background electric fields, we demonstrate new techniques to determine electric polarizabilities and baryon magnetic moments for both charged and neutral states. As we can study the quark mass dependence of observables with lattice QCD, the lattice will provide a crucial test of our understanding of low-energy QCD, which will be timely in light of ongoing experiments, such as at COMPASS and HI gamma S.

  6. Morphological weighted penalized least squares for background correction.

    PubMed

    Li, Zhong; Zhan, De-Jian; Wang, Jia-Jun; Huang, Jing; Xu, Qing-Song; Zhang, Zhi-Min; Zheng, Yi-Bao; Liang, Yi-Zeng; Wang, Hong

    2013-08-21

    Backgrounds existing in the analytical signal always impair the effectiveness of signals and compromise selectivity and sensitivity of analytical methods. In order to perform further qualitative or quantitative analysis, the background should be corrected with a reasonable method. For this purpose, a new automatic method for background correction, which is based on morphological operations and weighted penalized least squares (MPLS), has been developed in this paper. It requires neither prior knowledge about the background nor an iteration procedure or manual selection of a suitable local minimum value. The method has been successfully applied to simulated datasets as well as experimental datasets from different instruments. The results show that the method is quite flexible and could handle different kinds of backgrounds. The proposed MPLS method is implemented and available as an open source package at http://code.google.com/p/mpls.

  7. Product Aspect Clustering by Incorporating Background Knowledge for Opinion Mining.

    PubMed

    Chen, Yiheng; Zhao, Yanyan; Qin, Bing; Liu, Ting

    2016-01-01

    Product aspect recognition is a key task in fine-grained opinion mining. Current methods primarily focus on the extraction of aspects from the product reviews. However, it is also important to cluster synonymous extracted aspects into the same category. In this paper, we focus on the problem of product aspect clustering. The primary challenge is to properly cluster and generalize aspects that have similar meanings but different representations. To address this problem, we learn two types of background knowledge for each extracted aspect based on two types of effective aspect relations: relevant aspect relations and irrelevant aspect relations, which describe two different types of relationships between two aspects. Based on these two types of relationships, we can assign many relevant and irrelevant aspects into two different sets as the background knowledge to describe each product aspect. To obtain abundant background knowledge for each product aspect, we can enrich the available information with background knowledge from the Web. Then, we design a hierarchical clustering algorithm to cluster these aspects into different groups, in which aspect similarity is computed using the relevant and irrelevant aspect sets for each product aspect. Experimental results obtained in both camera and mobile phone domains demonstrate that the proposed product aspect clustering method based on two types of background knowledge performs better than the baseline approach without the use of background knowledge. Moreover, the experimental results also indicate that expanding the available background knowledge using the Web is feasible.

  8. Product Aspect Clustering by Incorporating Background Knowledge for Opinion Mining

    PubMed Central

    Chen, Yiheng; Zhao, Yanyan; Qin, Bing; Liu, Ting

    2016-01-01

    Product aspect recognition is a key task in fine-grained opinion mining. Current methods primarily focus on the extraction of aspects from the product reviews. However, it is also important to cluster synonymous extracted aspects into the same category. In this paper, we focus on the problem of product aspect clustering. The primary challenge is to properly cluster and generalize aspects that have similar meanings but different representations. To address this problem, we learn two types of background knowledge for each extracted aspect based on two types of effective aspect relations: relevant aspect relations and irrelevant aspect relations, which describe two different types of relationships between two aspects. Based on these two types of relationships, we can assign many relevant and irrelevant aspects into two different sets as the background knowledge to describe each product aspect. To obtain abundant background knowledge for each product aspect, we can enrich the available information with background knowledge from the Web. Then, we design a hierarchical clustering algorithm to cluster these aspects into different groups, in which aspect similarity is computed using the relevant and irrelevant aspect sets for each product aspect. Experimental results obtained in both camera and mobile phone domains demonstrate that the proposed product aspect clustering method based on two types of background knowledge performs better than the baseline approach without the use of background knowledge. Moreover, the experimental results also indicate that expanding the available background knowledge using the Web is feasible. PMID:27561001

  9. Texture induced microwave background anisotropies

    SciTech Connect

    Borrill, Julian; Copeland, Edmund J.; Liddle, Andrew R.; Stebbins, Albert; Veeraraghavan, Shoba

    1994-03-01

    We use numerical simulations to calculate the cosmic microwave background anisotropy induced by the evolution of a global texture field, with special emphasis on individual textures. Both spherically symmetric and general configurations are analyzed, and in the latter case we consider field configurations which exhibit unwinding events and also ones which do not. We compare the results given by evolving the field numerically under both the expanded core (XCORE) and non-linear sigma model (NLSM) approximations with the analytic predictions of the NLSM exact solution for a spherically symmetric self-similar (SSSS) unwinding. We find that the random unwinding configuration spots' typical peak height is 60-75\\% and angular size typically only 10% of those of the SSSS unwinding, and that random configurations without an unwinding event nonetheless may generate indistinguishable hot and cold spots. A brief comparison is made with other work.

  10. Background canceling surface alpha detector

    DOEpatents

    MacArthur, D.W.; Allander, K.S.; Bounds, J.A.

    1996-06-11

    A background canceling long range alpha detector which is capable of providing output proportional to both the alpha radiation emitted from a surface and to radioactive gas emanating from the surface. The detector operates by using an electrical field between first and second signal planes, an enclosure and the surface or substance to be monitored for alpha radiation. The first and second signal planes are maintained at the same voltage with respect to the electrically conductive enclosure, reducing leakage currents. In the presence of alpha radiation and radioactive gas decay, the signal from the first signal plane is proportional to both the surface alpha radiation and to the airborne radioactive gas, while the signal from the second signal plane is proportional only to the airborne radioactive gas. The difference between these two signals is proportional to the surface alpha radiation alone. 5 figs.

  11. Background canceling surface alpha detector

    DOEpatents

    MacArthur, Duncan W.; Allander, Krag S.; Bounds, John A.

    1996-01-01

    A background canceling long range alpha detector which is capable of providing output proportional to both the alpha radiation emitted from a surface and to radioactive gas emanating from the surface. The detector operates by using an electrical field between first and second signal planes, an enclosure and the surface or substance to be monitored for alpha radiation. The first and second signal planes are maintained at the same voltage with respect to the electrically conductive enclosure, reducing leakage currents. In the presence of alpha radiation and radioactive gas decay, the signal from the first signal plane is proportional to both the surface alpha radiation and to the airborne radioactive gas, while the signal from the second signal plane is proportional only to the airborne radioactive gas. The difference between these two signals is proportional to the surface alpha radiation alone.

  12. Deleterious background selection with recombination

    SciTech Connect

    Hudson, R.R.; Kaplan, N.L.

    1995-12-01

    An analytic expression for the expected nucleotide diversity is obtained for a neutral locus in a region with deleterious mutation and recombination. Our analytic results are used to predict levels of variation for the entire third chromosome of Drosophila melanogaster. The predictions are consistent with the low levels of variation that have been observed at loci near the centromeres of the third chromosome of D. melanogaster. However, the low levels of variation observed near the tips of this chromosome are not predicted using currently available estimates of the deleterious mutation rate and of selection coefficients. If considerably smaller selection coefficients are assumed, the low observed levels of variation at the tips of the third chromosome are consistent with the background selection model. 33 refs., 4 figs., 1 tab.

  13. Background illumination and automated perimetry.

    PubMed

    Klewin, K M; Radius, R L

    1986-03-01

    Visual field function in the right and left eyes of 31 normal volunteers was evaluated with an automated projection perimeter (OCTOPUS). Serial visual field evaluations were repeated in these same eyes with neutral filters of increasing optical density. We compared the results of threshold determinations with the different neutral filters in place before the examined eye. Significant reduction in threshold sensitivity at several test spots throughout the central 30 degrees visual field was seen with neutral density filters of 0.5 log units or greater. The low level of background illumination of the OCTOPUS perimeter (4.0 apostilbs) may allow relatively minor reduction in light transmission by the ocular media to produce significant changes in the recorded level of threshold sensitivity during visual field evaluation.

  14. Readout strategies for directional dark matter detection beyond the neutrino background

    NASA Astrophysics Data System (ADS)

    O'Hare, Ciaran A. J.; Green, Anne M.; Billard, Julien; Figueroa-Feliciano, Enectali; Strigari, Louis E.

    2015-09-01

    The search for weakly interacting massive particles (WIMPs) by direct detection faces an encroaching background due to coherent neutrino-nucleus scattering. As the sensitivity of these experiments improves, the question of how to best distinguish a dark matter signal from neutrinos will become increasingly important. A proposed method of overcoming this so-called "neutrino floor" is to utilize the directional signature that both neutrino- and dark-matter-induced recoils possess. We show that directional experiments can indeed probe WIMP-nucleon cross sections below the neutrino floor with little loss in sensitivity due to the neutrino background. In particular we find at low WIMP masses (around 6 GeV) the discovery limits for directional detectors penetrate below the nondirectional limit by several orders of magnitude. For high WIMP masses (around 100 GeV), the nondirectional limit is overcome by a factor of a few. Furthermore we show that even for directional detectors which can only measure one- or two-dimensional projections of the three-dimensional recoil track, the discovery potential is only reduced by a factor of 3 at most. We also demonstrate that while the experimental limitations of directional detectors, such as sense recognition and finite angular resolution, have a detrimental effect on the discovery limits, it is still possible to overcome the ultimate neutrino background faced by nondirectional detectors.

  15. [Onychomycoses due to molds].

    PubMed

    Chabasse, D; Pihet, M

    2014-12-01

    Onychomycoses represent about 30% of superficial mycosis that are encountered in Dermatology consults. Fungi such as dermatophytes, which are mainly found on the feet nails, cause nearly 50% of these onychopathies. Yeasts are predominantly present on hands, whereas non-dermatophytic moulds are very seldom involved in both foot and hand nails infections. According to literature, these moulds are responsible for 2 to 17% of onychomycoses. Nevertheless, we have to differentiate between onychomycoses due to pseudodermatophytes such as Neoscytalidium (ex-Scytalidium) and Onychocola canadensis, which present a high affinity for keratin, and onychomycoses due to filamentous fungi such as Aspergillus, Fusarium, Scopulariopsis, Acremonium... These saprophytic moulds are indeed most of the time considered as colonizers rather than real pathogens agents. Mycology and histopathology laboratories play an important role. They allow to identify the species that is involved in nail infection, but also to confirm parasitism by the fungus in the infected nails. Indeed, before attributing any pathogenic role to non-dermatophytic moulds, it is essential to precisely evaluate their pathogenicity through samples and accurate mycological and/or histological analysis. The treatment of onychomycoses due to non-dermatophytic moulds is difficult, as there is today no consensus. The choice of an antifungal agent will first depend on the species that is involved in the infection, but also on the severity of nail lesions and on the patient himself. In most cases, the onychomycosis will be cured with chemical or mechanical removing of the infected tissues, followed by a local antifungal treatment. In some cases, a systemic therapy will be discussed.

  16. Photosensitivity due to thiazides.

    PubMed

    Gómez-Bernal, S; Alvarez-Pérez, A; Rodríguez-Pazos, L; Gutiérrez-González, E; Rodríguez-Granados, M T; Toribio, J

    2014-05-01

    Thiazides are widely used diuretics that first became available in the 1950s. The first reports of photosensitivity reactions to thiazides were published shortly after the introduction of these drugs, but few cases have been described since. We review all the cases of photosensitivity due to thiazides published up to December 2011. We found 62 cases, 33 in women and 29 in men. The most common presentation was eczematous lesions in a photodistributed pattern, and the most common causative agent was hydrochlorothiazide. The results of photobiological studies were published in only some of the cases reviewed. In most cases, phototesting revealed an abnormal response to UV-A alone or to both UV-A and UV-B. In some cases, the results of phototesting were normal and only photopatch testing yielded abnormal results. Diagnosis of photosensitivity due to thiazides requires a high degree of suspicion. Ideally, diagnosis should be confirmed by a photobiological study. Copyright © 2012 Elsevier España, S.L. and AEDV. All rights reserved.

  17. Background radiation: natural and man-made.

    PubMed

    Thorne, M C

    2003-03-01

    A brief overview and comparison is given of dose rates arising from natural background radiation and the fallout from atmospheric testing of nuclear weapons. Although there are considerable spatial variations in exposure to natural background radiation, it is useful to give estimates of worldwide average overall exposures from the various components of that background. Cosmic-ray secondaries of low linear energy transfer (LET), mainly muons and photons, deliver about 280 microSv a(-1). Cosmic-ray neutrons deliver about another 100 microSv a(-1). These low- and high-LET exposures are relatively uniform to the whole body. The effective dose rate from cosmogenic radionuclides is dominated by the contribution of 12 microSv a(-1) from 14C. This is due to relatively uniform irradiation of all organs and tissues from low-energy beta particles. Primordial radionuclides and their progeny (principally the 238U and 232Th series, and 40K) contribute about 480 microSv a(-1) of effective dose by external irradiation. This is relatively uniform photon irradiation of the whole body. Internally incorporated 40K contributes a further 165 microSv a(-1) of effective dose in adults, mainly from beta particles, but with a significant gamma component. Equivalent doses from 40K are somewhat higher in muscle than other soft tissues, but the distinction is less than a factor of three. Uranium and thorium series radionuclides give rise to an average effective dose rate of around 120 microSv a(-1). This includes a major alpha particle component, and exposures of radiosensitive tissues in lung, liver, kidney and the skeleton are recognised as important contributors to effective dose. Overall, these various sources give a worldwide average effective dose rate of about 1160 microSv a(-1). Exposure to 222Rn, 220Rn and their short-lived progeny has to be considered separately. This is very variable both within and between countries. For 222Rn and its progeny, a worldwide average effective dose

  18. Optimal Local Searching for Fast and Robust Textureless 3D Object Tracking in Highly Cluttered Backgrounds.

    PubMed

    Seo, Byung-Kuk; Park, Jong-Il; Hinterstoisser, Stefan; Ilic, Slobodan

    2013-06-13

    Edge-based tracking is a fast and plausible approach for textureless 3D object tracking, but its robustness is still very challenging in highly cluttered backgrounds due to numerous local minima. To overcome this problem, we propose a novel method for fast and robust textureless 3D object tracking in highly cluttered backgrounds. The proposed method is based on optimal local searching of 3D-2D correspondences between a known 3D object model and 2D scene edges in an image with heavy background clutter. In our searching scheme, searching regions are partitioned into three levels (interior, contour, and exterior) with respect to the previous object region, and confident searching directions are determined by evaluating candidates of correspondences on their region levels; thus, the correspondences are searched among likely candidates in only the confident directions instead of searching through all candidates. To ensure the confident searching direction, we also adopt the region appearance, which is efficiently modeled on a newly defined local space (called a searching bundle). Experimental results and performance evaluations demonstrate that our method fully supports fast and robust textureless 3D object tracking even in highly cluttered backgrounds.

  19. Optimal local searching for fast and robust textureless 3D object tracking in highly cluttered backgrounds.

    PubMed

    Seo, Byung-Kuk; Park, Hanhoon; Park, Jong-Il; Hinterstoisser, Stefan; Ilic, Slobodan

    2014-01-01

    Edge-based tracking is a fast and plausible approach for textureless 3D object tracking, but its robustness is still very challenging in highly cluttered backgrounds due to numerous local minima. To overcome this problem, we propose a novel method for fast and robust textureless 3D object tracking in highly cluttered backgrounds. The proposed method is based on optimal local searching of 3D-2D correspondences between a known 3D object model and 2D scene edges in an image with heavy background clutter. In our searching scheme, searching regions are partitioned into three levels (interior, contour, and exterior) with respect to the previous object region, and confident searching directions are determined by evaluating candidates of correspondences on their region levels; thus, the correspondences are searched among likely candidates in only the confident directions instead of searching through all candidates. To ensure the confident searching direction, we also adopt the region appearance, which is efficiently modeled on a newly defined local space (called a searching bundle). Experimental results and performance evaluations demonstrate that our method fully supports fast and robust textureless 3D object tracking even in highly cluttered backgrounds.

  20. The relevance of individual genetic background and its role in animal models of epilepsy.

    PubMed

    Schauwecker, P Elyse

    2011-11-01

    Growing evidence has indicated that genetic factors contribute to the etiology of seizure disorders. Most epilepsies are multifactorial, involving a combination of additive and epistatic genetic variables. However, the genetic factors underlying epilepsy have remained unclear, partially due to epilepsy being a clinically and genetically heterogeneous syndrome. Similar to the human situation, genetic background also plays an important role in modulating both seizure susceptibility and its neuropathological consequences in animal models of epilepsy, which has too often been ignored or not been paid enough attention to in published studies. Genetic homogeneity within inbred strains and their general amenability to genetic manipulation have made them an ideal resource for dissecting the physiological function(s) of individual genes. However, the inbreeding that makes inbred mice so useful also results in genetic divergence between them. This genetic divergence is often unaccounted for but may be a confounding factor when comparing studies that have utilized distinct inbred strains. The purpose of this review is to discuss the effects of genetic background strain on epilepsy phenotypes of mice, to remind researchers that the background genetics of a knockout strain can have a profound influence on any observed phenotype, and outline the means by which to overcome potential genetic background effects in experimental models of epilepsy. Copyright © 2011 Elsevier B.V. All rights reserved.

  1. [The psychosocial background of sterile patients].

    PubMed

    Pusch, H H; Urdl, W; Walcher, W

    1989-01-01

    The psychosocial background of 300 childless couples from the Infertility Clinic of the Department of Gynecology and Obstetrics, University of Graz, was evaluated by means of a questionnaire and statistical analysis of data from their files. Points of special interest were problems such as interactions of the couple, motivations for the desire of children, psychosomatics, andrological investigation within the gynecological department, sexual habits and motivation and compliance concerning investigations and treatment. 72% of the questionnaires were returned. 50% of the sterile couples preferred to attend the infertility clinic together. 26% felt restrictions in their sexual behaviour due to the unrealized desire of children, 48% expected improvements in their partnership if they could have children. Compliance of male partners concerning the regular intake of prescribed medicaments was 83%, 63% accepted to stop smoking in cases of pathospermia.

  2. Background Pressure Effects on Krypton Hall Effect Thruster Internal Acceleration

    DTIC Science & Technology

    2013-08-01

    Technical Paper 3. DATES COVERED (From - To) August 2013- September 2013 4. TITLE AND SUBTITLE Background Pressure Effects on Krypton Hall Effect...Conference 2013, Washington, D.C., 6-10 October 2013. 14. ABSTRACT This study uses krypton propellant in a medium power Hall effect to amplify the...effect of background pressure due to the greater mobility of neutral krypton compared to neutral xenon. The use of krypton amplifies the effect of

  3. Particle production in a gravitational wave background

    NASA Astrophysics Data System (ADS)

    Jones, Preston; McDougall, Patrick; Singleton, Douglas

    2017-03-01

    We study the possibility that massless particles, such as photons, are produced by a gravitational wave. That such a process should occur is implied by tree-level Feynman diagrams such as two gravitons turning into two photons, i.e., g +g →γ +γ . Here we calculate the rate at which a gravitational wave creates a massless scalar field. This is done by placing the scalar field in the background of a plane gravitational wave and calculating the 4-current of the scalar field. Even in the vacuum limit of the scalar field it has a nonzero vacuum expectation value (similar to what occurs in the Higgs mechanism) and a nonzero current. We associate this with the production of scalar field quanta by the gravitational field. This effect has potential consequences for the attenuation of gravitational waves since the massless field is being produced at the expense of the gravitational field. This is related to the time-dependent Schwinger effect, but with the electric field replaced by the gravitational wave background and the electron/positron field quanta replaced by massless scalar "photons." Since the produced scalar quanta are massless there is no exponential suppression, as occurs in the Schwinger effect due to the electron mass.

  4. Role of genetic background in induced instability

    NASA Technical Reports Server (NTRS)

    Kadhim, Munira A.; Nelson, G. A. (Principal Investigator)

    2003-01-01

    Genomic instability is effectively induced by ionizing radiation. Recently, evidence has accumulated supporting a relationship between genetic background and the radiation-induced genomic instability phenotype. This is possibly due to alterations in proteins responsible for maintenance of genomic integrity or altered oxidative metabolism. Studies in human cell lines, human primary cells, and mouse models have been performed predominantly using high linear energy transfer (LET) radiation, or high doses of low LET radiation. The interplay between genetics, radiation response, and genomic instability has not been fully determined at low doses of low LET radiation. However, recent studies using low doses of low LET radiation suggest that the relationship between genetic background and radiation-induced genomic instability may be more complicated than these same relationships at high LET or high doses of low LET radiation. The complexity of this relationship at low doses of low LET radiation suggests that more of the population may be at risk than previously recognized and may have implications for radiation risk assessment.

  5. New window into stochastic gravitational wave background.

    PubMed

    Rotti, Aditya; Souradeep, Tarun

    2012-11-30

    A stochastic gravitational wave background (SGWB) would gravitationally lens the cosmic microwave background (CMB) photons. We correct the results provided in existing literature for modifications to the CMB polarization power spectra due to lensing by gravitational waves. Weak lensing by gravitational waves distorts all four CMB power spectra; however, its effect is most striking in the mixing of power between the E mode and B mode of CMB polarization. This suggests the possibility of using measurements of the CMB angular power spectra to constrain the energy density (Ω(GW)) of the SGWB. Using current data sets (QUAD, WMAP, and ACT), we find that the most stringent constraints on the present Ω(GW) come from measurements of the angular power spectra of CMB temperature anisotropies. In the near future, more stringent bounds on Ω(GW) can be expected with improved upper limits on the B modes of CMB polarization. Any detection of B modes of CMB polarization above the expected signal from large scale structure lensing could be a signal for a SGWB.

  6. Measurements of the cosmic background radiation

    NASA Technical Reports Server (NTRS)

    Lubin, P.; Villela, T.

    1987-01-01

    Maps of the large scale structure (theta is greater than 6 deg) of the cosmic background radiation covering 90 percent of the sky are now available. The data show a very strong 50-100 sigma (statistical error) dipole component, interpreted as being due to our motion, with a direction of alpha = 11.5 + or - 0.15 hours, sigma = -5.6 + or - 2.0 deg. The inferred direction of the velocity of our galaxy relative to the cosmic background radiation is alpha = 10.6 + or - 0.3 hours, sigma = -2.3 + or - 5 deg. This is 44 deg from the center of the Virgo cluster. After removing the dipole component, the data show a galactic signature but no apparent residual structure. An autocorrelation of the residual data, after substraction of the galactic component from a combined Berkeley (3 mm) and Princeton (12 mm) data sets, show no apparent structure from 10 to 180 deg with a rms of 0.01 mK(sup 2). At 90 percent confidence level limit of .00007 is placed on a quadrupole component.

  7. Credit where due.

    PubMed

    Friedman, Steven G

    2016-08-01

    The history of medicine is filled with stories of tireless researchers who failed to get credit for their hard work. Examples of this include Rosalind Franklin, who helped to elucidate the structure of DNA; Frederick Banting, who helped to discover insulin; and Jay McLean, who discovered heparin. The founding of the field of vascular surgery provides one of the most vivid examples of uncredited work. Even though Alexis Carrel was an unpaid, untitled assistant in Charles Guthrie's laboratory, it was Carrel alone who received a Nobel Prize for their work. In an attempt to give credit where due, the reasons for this injustice are described. Copyright © 2016 Society for Vascular Surgery. Published by Elsevier Inc. All rights reserved.

  8. Frequentist coverage properties of uncertainty intervals for weak Poisson signals in the presence of background

    NASA Astrophysics Data System (ADS)

    Coakley, K. J.; Splett, J. D.; Simons, D. S.

    2010-03-01

    We construct uncertainty intervals for weak Poisson signals in the presence of background. We consider the case where a primary experiment yields a realization of the signal plus background, and a second experiment yields a realization of the background. The data acquisition times, for the background-only experiment, Tbg, and the primary experiment, T, are selected so that their ratio, Tbg/T, varies from 1 to 25. The upper choice of 25 is motivated by an experimental study at the National Institute of Standards and Technology (NIST). The expected number of background counts in the primary experiment varies from 0.2 to 2. We construct 90% and 95% confidence intervals based on a propagation-of-errors method as well as two implementations of a Neyman procedure where acceptance regions are constructed based on a likelihood-ratio criterion that automatically determines whether the resulting confidence interval is one-sided or two-sided. In one of the implementations of the Neyman procedure due to Feldman and Cousins (FC), uncertainty in the expected background contribution is neglected. In the other implementation, we account for random uncertainty in the estimated expected background with a parametric bootstrap implementation of a method due to Conrad. We also construct minimum length Bayesian credibility intervals. For each method, we test for the presence of a signal based on the value of the lower endpoint of the uncertainty interval. In general, the propagation-of-errors method performs the worst compared to the other methods according to frequentist coverage and detection probability criteria, and sometimes produces nonsensical intervals where both endpoints are negative. The Neyman procedures generally yield intervals with better frequentist coverage properties compared to the Bayesian method except for some cases where Tbg/T = 1. In general, the Bayesian method yields intervals with lower detection probabilities compared to Neyman procedures. One of the main

  9. Acid rain: a background report

    SciTech Connect

    Glustrom, L.; Stolzenberg, J.

    1982-07-08

    This Staff Brief was prepared for the Wisconsin Legislative Council's Special Committee on Acid Rain to provide an introduction to the issue of acid rain. It is divided into four parts. Part I provides an overview on the controversies surrounding the measurement, formation and effects of acid rain. As described in Part I, the term acid rain is used to describe the deposition of acidic components through both wet deposition (e.g., rain or snow) and dry deposition (e.g., direct contact between atmospheric constituents and the land, water or vegetation of the earth). Part II presents background information on state agency activities relating to acid rain in Wisconsin, describes what is known about the occurrence of, susceptibility to and effects of acid rain in Wisconsin, and provides information related to man-made sources of sulfur and nitrogen oxides in Wisconsin. Part III describes major policies and regulations relating to acid rain which have been or are being developed jointly by the United States and Canadian governments, by the United States government and by the State of Wisconsin. Part IV briefly discusses possible areas for Committee action.

  10. The Diffuse Extreme Ultraviolet Background

    NASA Technical Reports Server (NTRS)

    Vallerga, John; Slavin, Jonathan

    1996-01-01

    Observations of the diffuse EUV background towards 138 different directions using the spectrometers aboard the Extreme Ultraviolet Explorer satellite (EUVE) have been combined into a spectrum from 150A to 730A and represent an effective exposure of 18 million seconds. There is no significant evidence of any non-local line flux in the resultant spectrum such as that from a hot coronal plasma. These results are inconsistent with the Wisconsin C and B broad-band surveys assuming the source is a logT = 5.8 - 6.1 hot plasma in ionization equilibrium with solar abundances, confirming the previous result of Jelinksy, Vallerga and Edelstein) (hereafter Paper 1) using an observation along the ecliptic with the same instrument. To make these results consistent with the previous broad-band surveys, the plasma responsible for the emission must either be depleted in Fe by a factor of approximately 6, be behind an absorbing slab of neutral H with a column of 2 x 10(exp 19)/sq cm, or not be in collisional ionization equilibrium (CIE). One such non-CIE model (Breitswerdt and Schmutzier) that explains the soft x-ray results is also inconsistent with this EUV data.

  11. Background modelling in Rietveld analysis

    SciTech Connect

    Richardson, J.W. Jr.

    1989-12-31

    The Rietveld method is a complete profile fitting technique, which requires modelling the total scattering from crystalline samples. Many diffraction experiments involve the analysis of scattering patterns containing additional noncrystalline scattering components; these components are broad oscillations superimposed on the sharp Bragg pattern. Conventional background functions cannot be used for the noncrystalline scattering; but treating the additional scattering as though it were from an amorphous material can provide additional structural information. This is demonstrated using AlPO{sub 4}-5, an aluminophosphate framework molecular sieve. The correlation function for the amorphous component has peaks close to interatomic distances also characteristic of the crystal. The cose agreement suggests that the amorphous component, although lacking long-range periodicity, has a similar atomic arrangement to the crystal. A calibration experiment is performed using a 50-50 wt% quartz-amorphous silica mixture; the crystal structural parameters obtained from Fourier-filtered data are compared with neutron powder diffraction refinement of quartz and single-crystal x-ray results. All refined parameters agree within 3-4 {sigma}. 2 tables, 5 refs, 6 figs. (DLC)

  12. Plenoptic background oriented schlieren imaging

    NASA Astrophysics Data System (ADS)

    Klemkowsky, Jenna N.; Fahringer, Timothy W.; Clifford, Christopher J.; Bathel, Brett F.; Thurow, Brian S.

    2017-09-01

    The combination of the background oriented schlieren (BOS) technique with the unique imaging capabilities of a plenoptic camera, termed plenoptic BOS, is introduced as a new addition to the family of schlieren techniques. Compared to conventional single camera BOS, plenoptic BOS is capable of sampling multiple lines-of-sight simultaneously. Displacements from each line-of-sight are collectively used to build a four-dimensional displacement field, which is a vector function structured similarly to the original light field captured in a raw plenoptic image. The displacement field is used to render focused BOS images, which qualitatively are narrow depth of field slices of the density gradient field. Unlike focused schlieren methods that require manually changing the focal plane during data collection, plenoptic BOS synthetically changes the focal plane position during post-processing, such that all focal planes are captured in a single snapshot. Through two different experiments, this work demonstrates that plenoptic BOS is capable of isolating narrow depth of field features, qualitatively inferring depth, and quantitatively estimating the location of disturbances in 3D space. Such results motivate future work to transition this single-camera technique towards quantitative reconstructions of 3D density fields.

  13. SNAP sky background at the north ecliptic pole

    SciTech Connect

    Aldering, Greg

    2002-07-01

    I summarize the extant direct and indirect data on the sky background SNAP will see at the North Ecliptic Pole over the wavelength range 0.4 < {lambda} < 1.7 {micro}m. At the spatial resolution of SNAP the sky background due to stars and galaxies is resolved, so the only source considered is zodiacal light. Several models are explored to provide interpolation in wavelength between the broadband data from HST and COBE observations. I believe the input data are now established well enough that the accuracy of the sky background presented here is sufficient for SNAP simulations, and that it will stand up to scrutiny by reviewers.

  14. The Low-Energy Background in XENON1T

    NASA Astrophysics Data System (ADS)

    Gao, Fei; Stein, Alec; Xenon1T Collaboration

    2017-01-01

    The XENON1T dark matter direct-detection experiment looks for hypothetical Weakly Interacting Massive Particles (WIMPs). WIMPs are expected to scatter off xenon nuclei at low energies, so understanding the low-energy background of the detector is crucial. In XENON1T, the background in the WIMP search region is due to radioactive decays stemming from the detector construction materials and impurities in the xenon itself. We show that our predicted low-energy background rate of 10-4events .kg-1 .day-1 .keV-1 matches XENON1T's design goals and is in agreement with the data taken during the commissioning of the detector.

  15. BOOK REVIEW: The Cosmic Microwave Background The Cosmic Microwave Background

    NASA Astrophysics Data System (ADS)

    Coles, Peter

    2009-08-01

    With the successful launch of the European Space Agency's Planck satellite earlier this year the cosmic microwave background (CMB) is once again the centre of attention for cosmologists around the globe. Since its accidental discovery in 1964 by Arno Penzias and Robert Wilson, this relic of the Big Bang has been subjected to intense scrutiny by generation after generation of experiments and has gradually yielded up answers to the deepest questions about the origin of our Universe. Most recently, the Wilkinson Microwave Anisotropy Probe (WMAP) has made a full-sky analysis of the pattern of temperature and polarization variations that helped establish a new standard cosmological model, confirmed the existence of dark matter and dark energy, and provided strong evidence that there was an epoch of primordial inflation. Ruth Durrer's book reflects the importance of the CMB for future developments in this field. Aimed at graduate students and established researchers, it consists of a basic introduction to cosmology and the theory of primordial perturbations followed by a detailed explanation of how these manifest themselves as measurable variations in the present-day radiation field. It then focuses on the statistical methods needed to obtain accurate estimates of the parameters of the standard cosmological model, and finishes with a discussion of the effect of gravitational lensing on the CMB and on the evolution of its spectrum. The book apparently grew out of various lecture notes on CMB anisotropies for graduate courses given by the author. Its level and scope are well matched to the needs of such an audience and the presentation is clear and well-organized. I am sure that this book will be a useful reference for more senior scientists too. If I have a criticism, it is not about what is in the book but what is omitted. In my view, one of the most exciting possibilities for future CMB missions, including Planck, is the possibility that they might discover physics

  16. Advanced Background Subtraction Applied to Aeroacoustic Wind Tunnel Testing

    NASA Technical Reports Server (NTRS)

    Bahr, Christopher J.; Horne, William C.

    2015-01-01

    An advanced form of background subtraction is presented and applied to aeroacoustic wind tunnel data. A variant of this method has seen use in other fields such as climatology and medical imaging. The technique, based on an eigenvalue decomposition of the background noise cross-spectral matrix, is robust against situations where isolated background auto-spectral levels are measured to be higher than levels of combined source and background signals. It also provides an alternate estimate of the cross-spectrum, which previously might have poor definition for low signal-to-noise ratio measurements. Simulated results indicate similar performance to conventional background subtraction when the subtracted spectra are weaker than the true contaminating background levels. Superior performance is observed when the subtracted spectra are stronger than the true contaminating background levels. Experimental results show limited success in recovering signal behavior for data where conventional background subtraction fails. They also demonstrate the new subtraction technique's ability to maintain a proper coherence relationship in the modified cross-spectral matrix. Beam-forming and de-convolution results indicate the method can successfully separate sources. Results also show a reduced need for the use of diagonal removal in phased array processing, at least for the limited data sets considered.

  17. Improved visual background extractor using an adaptive distance threshold

    NASA Astrophysics Data System (ADS)

    Han, Guang; Wang, Jinkuan; Cai, Xi

    2014-11-01

    Camouflage is a challenging issue in moving object detection. Even the recent and advanced background subtraction technique, visual background extractor (ViBe), cannot effectively deal with it. To better handle camouflage according to the perception characteristics of the human visual system (HVS) in terms of minimum change of intensity under a certain background illumination, we propose an improved ViBe method using an adaptive distance threshold, named IViBe for short. Different from the original ViBe using a fixed distance threshold for background matching, our approach adaptively sets a distance threshold for each background sample based on its intensity. Through analyzing the performance of the HVS in discriminating intensity changes, we determine a reasonable ratio between the intensity of a background sample and its corresponding distance threshold. We also analyze the impacts of our adaptive threshold together with an update mechanism on detection results. Experimental results demonstrate that our method outperforms ViBe even when the foreground and background share similar intensities. Furthermore, in a scenario where foreground objects are motionless for several frames, our IViBe not only reduces the initial false negatives, but also suppresses the diffusion of misclassification caused by those false negatives serving as erroneous background seeds, and hence shows an improved performance compared to ViBe.

  18. Reducing 68Ge Background in Dark Matter Experiments

    SciTech Connect

    Kouzes, Richard T.; Orrell, John L.

    2011-03-01

    Experimental searches for dark matter include experiments with sub-0.5 keV-energy threshold high purity germanium detectors. Experimental efforts, in partnership with the CoGeNT Collaboration operating at the Soudan Underground Laboratory, are focusing on energy threshold reduction via noise abatement, reduction of backgrounds from cosmic ray generated isotopes, and ubiquitous environmental radioactive sources. The most significant cosmic ray produced radionuclide is 68Ge. This paper evaluates reducing this background by freshly mining and processing germanium ore. The most probable outcome is a reduction of the background by a factor of two, and at most a factor of four. A very cost effective alternative is to obtain processed Ge as soon as possible and store it underground for 18 months.

  19. A novel method to remove GPR background noise based on the similarity of non-neighboring regions

    NASA Astrophysics Data System (ADS)

    Montiel-Zafra, V.; Canadas-Quesada, F. J.; Vera-Candeas, P.; Ruiz-Reyes, N.; Rey, J.; Martinez, J.

    2017-09-01

    Ground penetrating radar (GPR) is a non-destructive technique that has been widely used in many areas of research, such as landmine detection or subsurface anomalies, where it is required to locate targets embedded within a background medium. One of the major challenges in the research of GPR data remains the improvement of the image quality of stone materials by means of detection of true anisotropies since most of the errors are caused by an incorrect interpretation by the users. However, it is complicated due to the interference of the horizontal background noise, e.g., the air-ground interface, that reduces the high-resolution quality of radargrams. Thus, weak or deep anisotropies are often masked by this type of noise. In order to remove the background noise obtained by GPR, this work proposes a novel background removal method assuming that the horizontal noise shows repetitive two-dimensional regions along the movement of the GPR antenna. Specifically, the proposed method, based on the non-local similarity of regions over the distance, computes similarities between different regions of the same depth in order to identify most repetitive regions using a criterion to avoid closer regions. Evaluations are performed using a set of synthetic and real GPR data. Experimental results show that the proposed method obtains promising results compared to the classic background removal techniques and the most recently published background removal methods.

  20. Unsupervised background-constrained tank segmentation of infrared images in complex background based on the Otsu method.

    PubMed

    Zhou, Yulong; Gao, Min; Fang, Dan; Zhang, Baoquan

    2016-01-01

    In an effort to implement fast and effective tank segmentation from infrared images in complex background, the threshold of the maximum between-class variance method (i.e., the Otsu method) is analyzed and the working mechanism of the Otsu method is discussed. Subsequently, a fast and effective method for tank segmentation from infrared images in complex background is proposed based on the Otsu method via constraining the complex background of the image. Considering the complexity of background, the original image is firstly divided into three classes of target region, middle background and lower background via maximizing the sum of their between-class variances. Then, the unsupervised background constraint is implemented based on the within-class variance of target region and hence the original image can be simplified. Finally, the Otsu method is applied to simplified image for threshold selection. Experimental results on a variety of tank infrared images (880 × 480 pixels) in complex background demonstrate that the proposed method enjoys better segmentation performance and even could be comparative with the manual segmentation in segmented results. In addition, its average running time is only 9.22 ms, implying the new method with good performance in real time processing.

  1. Under The Background Influence (UTBI)

    NASA Astrophysics Data System (ADS)

    Russu, A.; Escobar, N.; Sanchis, J.; Monrabal, F.; Moreno, M.; Gisbert, R.

    UTBI is an ESA Students project with the aim of radiation measurement on board the International Space Station ISS The project was presented in the scope of the SUCCESS Student Contest Special Opportunities and was selected for implementation onboard the ISS during ESA s Long Duration Mission The instrument is based on a COST Semi-Insulating SI Cadmium Zinc Telluride CdZnTe detector grown by the High-Pressure Electro-Dynamic Gradient HP-EDG technique The crystal volume is 15x15x7 5 mm 3 and with a Co-Planar Grid CPG electrode configuration The Analog Front End Electronics AFEE is integrated in an commercial ASIC for noise reduction purpose and designed for a large energy range 30 KeV-8 MeV The instrument electronics are designed with COST electronic components and with the ESA contest maximum restrictions of 1 kg mass 20x20x20 cm 3 volume ISS electromagnetic compatible and no telemetry capability The main scientific goal for the instrument is to achieve nuclear-radiation spectroscopy by the bi-parametric technique data analysis for radiation identification Previous work has been performed in two ways on one hand simulations SPENVIS CREME96 GEANT4 SRIM EFS proving the viability of the mission and on the other hand experimental laboratory measurements and data analysis for gamma ray sources Co57 Cd109 Cs137 Launch of the experiment is foreseen in the October 2006 timeframe and planned for 8 days data collection on board the ISS

  2. [Endometriosis. Pathophysiological background for treatment].

    PubMed

    Hernández-Valencia, Marcelino; Zárate, Arturo

    2009-01-01

    Endometriosis is the third cause of gynecological morbidity and the complications are associated to ectopically endometrial tissue implantation. The interest on this disease is the functional disability and its association with sterility. It has been established that endometrial growth is estrogen-dependent and that progesterone inhibits the cellular proliferation mediated by estrogens, therefore in endometriosis there is not an adequate response to hormonal signals that control the proliferative activity. It has been described that peritoneal fluid in women with endometriosis has high concentrations of cytokines, growth factors and activated macrophages, which have been shown to have adverse effects on fertility. Therefore, these are not the only causes of infertility since it has been described that women with endometriosis seem to have poor ovarian reserve and ovular quality. When there is infertility, the tendency is to treat the endometriosis due to the changes caused by ectopic tissue presented at the immunological level and in the structure of genital organs, which disturbs the conception process. It has been observed that endometriosis recurs after a surgical procedure. For this reason we should be consider all therapeutic possibilities.

  3. Phonon features in terahertz photoconductivity spectra due to data analysis artifact: A case study on organometallic halide perovskites

    NASA Astrophysics Data System (ADS)

    La-o-vorakiat, Chan; Cheng, Liang; Salim, Teddy; Marcus, Rudolph A.; Michel-Beyerle, Maria-Elisabeth; Lam, Yeng Ming; Chia, Elbert E. M.

    2017-03-01

    We propose a simple scenario where the superimposed phonon modes on the photoconductive spectra are experimental artifacts due to the invalid formula used in data analysis. By use of experimental and simulated data of CH3NH3PbI3 perovskites as a case study, we demonstrate that a correction term must be included in the approximated thin-film formula used in the literature; otherwise, parts of the spectra with high background permittivity near the phonon-mode resonances might interfere with the transient photoconductivity. The implication of this work is not limited to perovskites but other materials with strong vibrational modes within the THz spectral range.

  4. [Tobacco abuse: background and countermeasures].

    PubMed

    Bolliger, C T

    1998-01-14

    The extreme extent of world-wide tobacco consumption, mainly in the form of cigarette smoking, is a phenomenon of the 20th century and can be termed a pandemic. Partly due to the massive and uninhibited advertising of the tobacco companies smoking prevalence has dramatically increased until the mid-sixties. Since then thousands of reports on the damaging-effects of smoking have been published which has led to a change in attitude and to a decrease in smoking prevalence at least in industrialised countries. In Switzerland about 25% of the adult population smoke, but the percentage in the age group between 25 to 34 years is significantly higher. Smoking is the most important preventable cause of disease; this has been underlined by recent findings that about 50% of smokers will eventually die from their habit. Regular smokers-usually defined as regularly smoking more than 10-15 cigarettes daily-are nicotine dependent and do not smoke because they want to, but because they have to. Although 60-70% of smokers would like to quit, they fail without help. Nevertheless, smoking cessation is possible: the most important issue is the smoker's own motivation. Psychological counselling and nicotine replacement therapy (NRT) given as either patch, chewing gum, or nasal spray are merely aids to enhance success. With intensive counselling and NRT a maximum success rate of about 30% can be expected assessed 1 year after quit date. In general the use of NRT doubles the success rate of any chosen form of intervention. Cessation of smoking in young people is currently considered the best form of prevention.

  5. Ocular injury due to bungee jumping.

    PubMed

    Curtis, Edward B; Collin, H Barry

    1999-01-01

    BACKGROUND: Bungee jumping is a well-established recreational activity in New Zealand and Australia which may be associated with injuries to the eyes and other tissues. CASE HISTORY: A patient with a retinal haemorrhage which resulted from bungee jumping is reported and the clinical characteristics described. DISCUSSION: There have been several reports of injury due to bungee jumping. The types of ocular injury are reviewed and the aetiological theories discussed.

  6. Speech recognition in natural background noise.

    PubMed

    Meyer, Julien; Dentel, Laure; Meunier, Fanny

    2013-01-01

    In the real world, human speech recognition nearly always involves listening in background noise. The impact of such noise on speech signals and on intelligibility performance increases with the separation of the listener from the speaker. The present behavioral experiment provides an overview of the effects of such acoustic disturbances on speech perception in conditions approaching ecologically valid contexts. We analysed the intelligibility loss in spoken word lists with increasing listener-to-speaker distance in a typical low-level natural background noise. The noise was combined with the simple spherical amplitude attenuation due to distance, basically changing the signal-to-noise ratio (SNR). Therefore, our study draws attention to some of the most basic environmental constraints that have pervaded spoken communication throughout human history. We evaluated the ability of native French participants to recognize French monosyllabic words (spoken at 65.3 dB(A), reference at 1 meter) at distances between 11 to 33 meters, which corresponded to the SNRs most revealing of the progressive effect of the selected natural noise (-8.8 dB to -18.4 dB). Our results showed that in such conditions, identity of vowels is mostly preserved, with the striking peculiarity of the absence of confusion in vowels. The results also confirmed the functional role of consonants during lexical identification. The extensive analysis of recognition scores, confusion patterns and associated acoustic cues revealed that sonorant, sibilant and burst properties were the most important parameters influencing phoneme recognition. . Altogether these analyses allowed us to extract a resistance scale from consonant recognition scores. We also identified specific perceptual consonant confusion groups depending of the place in the words (onset vs. coda). Finally our data suggested that listeners may access some acoustic cues of the CV transition, opening interesting perspectives for future studies.

  7. Mouse Genetic Background Influences the Dental Phenotype

    PubMed Central

    Li, Yong; Konicki, William S.; Wright, J. Timothy; Suggs, Cynthia; Xue, Hui; Kuehl, Melissa A.; Kulkarni, Ashok B.; Gibson, Carolyn W.

    2014-01-01

    Dental enamel covers the crown of the vertebrate tooth and is considered to be the hardest tissue in the body. Enamel develops during secretion of an extracellular matrix by ameloblast cells in the tooth germ, prior to eruption of the tooth into the oral cavity. Secreted enamel proteins direct mineralization patterns during the maturation stage of amelogenesis as the tooth prepares to erupt. The amelogenins are the most abundant enamel proteins, and are required for normal enamel development. Phenotypic differences were observed between incisors from individual Amelx (Amelogenin) null mice that had a mixed 129xC57BL/6J genetic background, and between inbred wld-type (WT) mice with different genetic backgrounds (C57BL/6J, C3H/HEJ, FVB/NJ). We hypothesized this could be due to modifier genes, as human patients with a mutation in an enamel protein gene causing the enamel defect amelogenesis imperfecta (AI) also can have varied appearance of dentitions within a kindred. Enamel density measurements varied for all WT inbred strains midway during incisor development. Enamel thickness varied between some WT strains and, unexpectedly, dentin density varied extensively between incisors and molars of all WT and Amelx null strains studied. WT FVB/NJ incisors were more similar to Amelx null than to the other WT strains in incisor height/weight ratio and pattern of enamel mineralization. Strain-specific differences led to the conclusion that modifier genes may be implicated in determining both normal development and severity of enamel appearance in AI mouse models and may in future studies be related to phenotypic heterogeneity within human AI kindreds reported in the literature. PMID:24732779

  8. Speech Recognition in Natural Background Noise

    PubMed Central

    Meyer, Julien; Dentel, Laure; Meunier, Fanny

    2013-01-01

    In the real world, human speech recognition nearly always involves listening in background noise. The impact of such noise on speech signals and on intelligibility performance increases with the separation of the listener from the speaker. The present behavioral experiment provides an overview of the effects of such acoustic disturbances on speech perception in conditions approaching ecologically valid contexts. We analysed the intelligibility loss in spoken word lists with increasing listener-to-speaker distance in a typical low-level natural background noise. The noise was combined with the simple spherical amplitude attenuation due to distance, basically changing the signal-to-noise ratio (SNR). Therefore, our study draws attention to some of the most basic environmental constraints that have pervaded spoken communication throughout human history. We evaluated the ability of native French participants to recognize French monosyllabic words (spoken at 65.3 dB(A), reference at 1 meter) at distances between 11 to 33 meters, which corresponded to the SNRs most revealing of the progressive effect of the selected natural noise (−8.8 dB to −18.4 dB). Our results showed that in such conditions, identity of vowels is mostly preserved, with the striking peculiarity of the absence of confusion in vowels. The results also confirmed the functional role of consonants during lexical identification. The extensive analysis of recognition scores, confusion patterns and associated acoustic cues revealed that sonorant, sibilant and burst properties were the most important parameters influencing phoneme recognition. . Altogether these analyses allowed us to extract a resistance scale from consonant recognition scores. We also identified specific perceptual consonant confusion groups depending of the place in the words (onset vs. coda). Finally our data suggested that listeners may access some acoustic cues of the CV transition, opening interesting perspectives for future studies

  9. Experimental demonstration of ecological character displacement

    PubMed Central

    2008-01-01

    Background The evolutionary consequences of competition are of great interest to researchers studying sympatric speciation, adaptive radiation, species coexistence and ecological assembly. Competition's role in driving evolutionary change in phenotypic distributions, and thus causing ecological character displacement, has been inferred from biogeographical data and measurements of divergent selection on a focal species in the presence of competitors. However, direct experimental demonstrations of character displacement due to competition are rare. Results We demonstrate a causal role for competition in ecological character displacement. Using populations of the bacterium Escherichia coli that have adaptively diversified into ecotypes exploiting different carbon resources, we show that when interspecific competition is relaxed, phenotypic distributions converge. When we reinstate competition, phenotypic distributions diverge. Conclusion This accordion-like dynamic provides direct experimental evidence that competition for resources can cause evolutionary shifts in resource-related characters. PMID:18234105

  10. Data analysis of cosmic microwave background experiments

    NASA Astrophysics Data System (ADS)

    Abroe, Matthew Edmund

    2004-12-01

    The cosmic microwave background (CMB) is a powerful tool for determining and constraining the fundamental properties of our universe. In this thesis we present various computational and statistical techniques used to analyze datasets from CMB experiments, and apply them to both simulated and actual datasets. The algorithms presented in this thesis perform a variety of tasks in relation to the goal of extracting scientific information from CMB data sets. The CMB anisotropy power spectrum is sensitive to numerous parameters that determine the evolutionary and large scale properties of our universe. Now that numerous experiments have mapped the CMB intensity fluctuations on overlapping regions of the sky it is important to ensure that the various experiments are indeed observing the same signal. We cross-correlate the cosmic microwave background temperature anisotropy maps from the WMAP, MAXIMA-I, and MAXIMA-II experiments. The results conclusively show that the three experiments not only display the same statistical properties of the CMB anisotropy, but also detect the same features wherever the observed sky areas overlap. We conclude that the contribution of systematic errors to these maps is negligible and that MAXIMA and WMAP have accurately mapped the cosmic microwave background anisotropy. Due to a quadrapole anisotropy at last scattering it is predicted that the CMB photons should be linearly polarized, and that the polarization intensity will be roughly an order of magnitude lower than the intensity fluctuations. Two computationally intensive methods for simulating the CMB polarization signal on the sky are presented. Now that CMB polarization experiments are currently producing data sets new algorithms for analyzing polarization time stream data must be developed and tested. We demonstrate how to generate simulations of a polarization experiment in the temporal domain and apply these simulations to the MAXIPOL case. We develop a maximum likelihood map making

  11. The unusual smoothness of the extragalactic unresolved radio background

    SciTech Connect

    Holder, Gilbert P.

    2014-01-01

    If the radio background is coming from cosmological sources, there should be some amount of clustering due to the large scale structure in the universe. Simple models for the expected clustering combined with the recent measurement by ARCADE-2 of the mean extragalactic temperature lead to predicted clustering levels that are substantially above upper limits from searches for anisotropy on arcminute scales using the Australia Telescope Compact Array and the Very Large Array. The rms temperature variations in the cosmic radio background appear to be more than a factor of 10 smaller (in temperature) than the fluctuations in the cosmic infrared background. It is therefore extremely unlikely that this background comes from galaxies, galaxy clusters, or any sources that trace dark matter halos at z ≲ 5, unless typical sources are smooth on arcminute scales, requiring typical sizes of several Mpc.

  12. Medication adherence in people of culturally and linguistically diverse backgrounds: a meta-analysis.

    PubMed

    Manias, Elizabeth; Williams, Allison

    2010-06-01

    Medication adherence is of particular importance for people of culturally and linguistically diverse (CALD) backgrounds due to language difficulties, lack of social and organizational supports, lack of access to healthcare resources, and disengagement with the health-care system. To evaluate the impact of interventions to improve medication adherence in people of CALD backgrounds through a systematic review and meta-analysis. A search was performed using the following databases: Cochrane Database of Systematic Reviews, Cumulative Index to Nursing & Allied Health Literature, EMBASE, Journals@Ovid, PsychInfo, PubMed, Science Direct, Scopus, and Web of Science. Databases were searched from January 1978 to October 2009. Forty-six articles reviewed were assessed as being relevant, which included 36 randomized controlled trials, 2 observational cohort studies, and 8 quasi-experimental studies. The most common method for assessing medication adherence was self-reporting measures, such as the Morisky Scale and its modifications. Few studies used combinations of adherence measures, and adherence involving a medication event monitoring system (MEMS) was used in only 6 studies. Individuals of CALD backgrounds were recruited with people of non-CALD backgrounds and subsequent analyses tended to be undertaken of the whole sample. Twenty studies showed statistically significant improvements in medication adherence, 15 of which were randomized controlled trials. Six of the successful interventions involved delivery by a bilingual person or the use of translated materials and 4 involved the use of a conceptual model. Meta-analyses demonstrated modest improvements in medication adherence. Relatively little high-quality work has been conducted on adherence-enhancing interventions for people of CALD backgrounds. Greater attention needs to be given to examining the needs of specific CALD population groups. Future researchers should consider rigorously testing interventions that take

  13. Dynamics of electron-plasma vortex in background vorticity distribution.

    PubMed

    Kiwamoto, Y; Ito, K; Sanpei, A; Mohri, A

    2000-10-09

    Dynamics of a point vortex in interaction with a broad profile of background vorticity is studied experimentally by using an electron plasma. The observed motion of the vortex compares favorably with a recently proposed theoretical model [D. A. Schecter and D. H. E. Dubin, Phys. Rev. Lett. 83, 2191 (1999)]. Perturbations in the background distribution in the wake of the spiral orbit of the vortex amount to several tens of percent and are considered to be a major reason for deviations of the observation from the linear theoretical model.

  14. Dynamics of Electron-Plasma Vortex in Background Vorticity Distribution

    NASA Astrophysics Data System (ADS)

    Kiwamoto, Y.; Ito, K.; Sanpei, A.; Mohri, A.

    2000-10-01

    Dynamics of a point vortex in interaction with a broad profile of background vorticity is studied experimentally by using an electron plasma. The observed motion of the vortex compares favorably with a recently proposed theoretical model [D. A. Schecter and D. H. E. Dubin, Phys. Rev. Lett. 83, 2191 (1999)]. Perturbations in the background distribution in the wake of the spiral orbit of the vortex amount to several tens of percent and are considered to be a major reason for deviations of the observation from the linear theoretical model.

  15. See-through integral imaging display with background occlusion capability.

    PubMed

    Yamaguchi, Yuta; Takaki, Yasuhiro

    2016-01-20

    Background occlusion capability is provided to a flat-panel-type integral imaging display that has a transparent screen and can superimpose three-dimensional (3D) images on real scenes. A symmetric integral imaging system that comprises two integral imaging systems connected by an additional lens array, is proposed. Elementary images are displayed on a flat-panel display on one integral imaging system to generate 3D images, and the occlusion mask patterns are displayed on a flat-panel display on the other integral imaging system to selectively block rays from background scenes. The proposed system was constructed and experimentally verified.

  16. Optimal Background Estimators in Single-Molecule FRET Microscopy.

    PubMed

    Preus, Søren; Hildebrandt, Lasse L; Birkedal, Victoria

    2016-09-20

    Single-molecule total internal reflection fluorescence (TIRF) microscopy constitutes an umbrella of powerful tools that facilitate direct observation of the biophysical properties, population heterogeneities, and interactions of single biomolecules without the need for ensemble synchronization. Due to the low signal/noise ratio in single-molecule TIRF microscopy experiments, it is important to determine the local background intensity, especially when the fluorescence intensity of the molecule is used quantitatively. Here we compare and evaluate the performance of different aperture-based background estimators used particularly in single-molecule Förster resonance energy transfer. We introduce the general concept of multiaperture signatures and use this technique to demonstrate how the choice of background can affect the measured fluorescence signal considerably. A new, to our knowledge, and simple background estimator is proposed, called the local statistical percentile (LSP). We show that the LSP background estimator performs as well as current background estimators at low molecular densities and significantly better in regions of high molecular densities. The LSP background estimator is thus suited for single-particle TIRF microscopy of dense biological samples in which the intensity itself is an observable of the technique. Copyright © 2016 Biophysical Society. Published by Elsevier Inc. All rights reserved.

  17. 2D Vortex Motion Driven by a Background Vorticity Gradient.

    NASA Astrophysics Data System (ADS)

    Schecter, D. A.; Dubin, D. H. E.

    1999-11-01

    A background vorticity gradient can strongly influence the motion of vortices in 2D fluids. Examples are vortex motion in magnetized electron plasmas and hurricane tracks in planetary atmospheres.(See for example Huang, Fine and Driscoll, Phys. Rev. Lett. 74), 4424 (1995); C.G. Rossby, J. Mar. Res. 7, 175 (1948). Here, the vortex motion is examined numerically and analytically for the case of a point-like vortex in a background shear flow that is initially axisymmetric. The vortex acts to level the local background vorticity gradient. Conservation of angular momentum dictates that positive vortices (``clumps'') and negative vortices (``holes'') react oppositely: clumps move up the gradient, whereas holes move down the gradient. Both clumps and holes can be classified as either prograde or retrograde, depending on whether they rotate with or against the local background shear. An analysis, in which the background response to the vortex is linearized, gives the trajectory of a small retrograde vortex. When the vortex is prograde, the background response is nonlinear. A prograde vortex moves along the gradient at a slower rate that is given by a simple ``mix-and-move'' estimate. This rate vanishes when the local shear is sufficiently large, due to the trapping of background fluid around the vortex.

  18. Effects of placement point of background music on shopping website.

    PubMed

    Lai, Chien-Jung; Chiang, Chia-Chi

    2012-01-01

    Consumer on-line behaviors are more important than ever due to highly growth of on-line shopping. The purposes of this study were to design placement methods of background music for shopping website and examine the effect on browsers' emotional and cognitive response. Three placement points of background music during the browsing, i.e. 2 min., 4 min., and 6 min. from the start of browsing were considered for entry points. Both browsing without music (no music) and browsing with constant music volume (full music) were treated as control groups. Participants' emotional state, approach-avoidance behavior intention, and action to adjust music volume were collected. Results showed that participants had a higher level of pleasure, arousal and approach behavior intention for the three placement points than for no music and full music. Most of the participants for full music (5/6) adjusted the background music. Only 16.7% (3/18) participants for other levels turn off the background music. The results indicate that playing background music after the start of browsing is benefit for on-line shopping atmosphere. It is inappropriate to place background music at the start of browsing shopping website. The marketer must manipulated placement methods of background music for a web store carefully.

  19. 2D Vortex Motion Driven by a Background Vorticity Gradient.

    NASA Astrophysics Data System (ADS)

    Schecter, D. A.; Dubin, D. H. E.

    1999-11-01

    A background vorticity gradient can strongly influence the motion of vortices in 2D fluids. Examples are vortex motion in magnetized electron plasmas and hurricane tracks in planetary atmospheres. Here, the vortex motion is examined numerically and analytically for the case of a point-like vortex in a background shear flow that is initially axisymmetric.(Schecter and Dubin, to appear in Phys. Rev. Lett. (1999).) The vortex acts to level the local background vorticity gradient. Conservation of angular momentum dictates that positive vortices (``clumps'') and negative vortices (``holes'') react oppositely: clumps move up the gradient, whereas holes move down the gradient. Both clumps and holes can be classified as either prograde or retrograde, depending on whether they rotate with or against the local background shear. An analysis, in which the background response to the vortex is linearized, gives the trajectory of a small retrograde vortex. When the vortex is prograde, the background response is nonlinear. A prograde vortex moves along the gradient at a slower rate that is given by a simple ``mix-and-move'' estimate. This rate vanishes when the local shear is sufficiently large, due to the trapping of background fluid around the vortex.

  20. 25 CFR 556.4 - Background investigations.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 25 Indians 2 2012-04-01 2012-04-01 false Background investigations. 556.4 Section 556.4 Indians NATIONAL INDIAN GAMING COMMISSION, DEPARTMENT OF THE INTERIOR GAMING LICENSES AND BACKGROUND INVESTIGATIONS FOR KEY EMPLOYEES AND PRIMARY MANAGEMENT OFFICIALS BACKGROUND INVESTIGATIONS FOR PRIMARY MANAGEMENT...

  1. 25 CFR 556.4 - Background investigations.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 2 2011-04-01 2011-04-01 false Background investigations. 556.4 Section 556.4 Indians NATIONAL INDIAN GAMING COMMISSION, DEPARTMENT OF THE INTERIOR GAMING LICENSES AND BACKGROUND INVESTIGATIONS FOR KEY EMPLOYEES AND PRIMARY MANAGEMENT OFFICIALS BACKGROUND INVESTIGATIONS FOR PRIMARY MANAGEMENT...

  2. 45 CFR 650.16 - Background rights.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 3 2010-10-01 2010-10-01 false Background rights. 650.16 Section 650.16 Public... Background rights. The Foundation will acquire rights to a research performer's pre-existing technology only... of the cognizant Program Manager, will negotiate a background rights provision. If the...

  3. 16 CFR 1101.1 - General background.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 16 Commercial Practices 2 2011-01-01 2011-01-01 false General background. 1101.1 Section 1101.1 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION CONSUMER PRODUCT SAFETY ACT REGULATIONS INFORMATION DISCLOSURE UNDER SECTION 6(b) OF THE CONSUMER PRODUCT SAFETY ACT Background § 1101.1 General background....

  4. 16 CFR 1101.1 - General background.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 16 Commercial Practices 2 2010-01-01 2010-01-01 false General background. 1101.1 Section 1101.1 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION CONSUMER PRODUCT SAFETY ACT REGULATIONS INFORMATION DISCLOSURE UNDER SECTION 6(b) OF THE CONSUMER PRODUCT SAFETY ACT Background § 1101.1 General background. (a) Basic purpose. This rule sets...

  5. Human Detection Based on the Generation of a Background Image and Fuzzy System by Using a Thermal Camera

    PubMed Central

    Jeon, Eun Som; Kim, Jong Hyun; Hong, Hyung Gil; Batchuluun, Ganbayar; Park, Kang Ryoung

    2016-01-01

    Recently, human detection has been used in various applications. Although visible light cameras are usually employed for this purpose, human detection based on visible light cameras has limitations due to darkness, shadows, sunlight, etc. An approach using a thermal (far infrared light) camera has been studied as an alternative for human detection, however, the performance of human detection by thermal cameras is degraded in case of low temperature differences between humans and background. To overcome these drawbacks, we propose a new method for human detection by using thermal camera images. The main contribution of our research is that the thresholds for creating the binarized difference image between the input and background (reference) images can be adaptively determined based on fuzzy systems by using the information derived from the background image and difference values between background and input image. By using our method, human area can be correctly detected irrespective of the various conditions of input and background (reference) images. For the performance evaluation of the proposed method, experiments were performed with the 15 datasets captured under different weather and light conditions. In addition, the experiments with an open database were also performed. The experimental results confirm that the proposed method can robustly detect human shapes in various environments. PMID:27043564

  6. Cosmic Needles versus Cosmic Microwave Background Radiation

    NASA Astrophysics Data System (ADS)

    Li, Aigen

    2003-02-01

    It has been suggested by a number of authors that the 2.7 K cosmic microwave background (CMB) radiation might have arisen from the radiation of ``Population III'' objects thermalized by conducting cosmic graphite/iron needle-shaped dust. Due to a lack of an accurate solution to the absorption properties of exceedingly elongated grains, in existing literature which studies the CMB thermalizing process they are generally modeled as (1) needle-like spheroids in terms of the Rayleigh approximation, (2) infinite cylinders, and (3) antennae. We show here that the Rayleigh approximation is not valid since the Rayleigh criterion is not satisfied for highly conducting needles. We also show that the available intergalactic iron dust, if modeled as infinite cylinders, is not sufficient to supply the required opacity at long wavelengths to obtain the observed isotropy and Planckian nature of the CMB. If appealing to the antenna theory, conducting iron needles with exceedingly large elongations ( >104) appear able to provide sufficient opacity to thermalize the CMB within the iron density limit. But the applicability of the antenna theory to exceedingly thin needles of nanometer/micrometer thickness has not yet been verified.

  7. The Course of Due Process.

    ERIC Educational Resources Information Center

    Getty, Laura A.; Summy, Sarah E.

    2004-01-01

    Discussion of due process rights for children with disabilities considers common issues leading to due process requests, due process procedures, hearing officers, procedural violations, effects of due process meetings, and areas for improvement (i.e., accountability, paperwork). Tables list categories of procedural violations with examples and…

  8. Stacked Multilayer Self-Organizing Map for Background Modeling.

    PubMed

    Zhao, Zhenjie; Zhang, Xuebo; Fang, Yongchun

    2015-09-01

    In this paper, a new background modeling method called stacked multilayer self-organizing map background model (SMSOM-BM) is proposed, which presents several merits such as strong representative ability for complex scenarios, easy to use, and so on. In order to enhance the representative ability of the background model and make the parameters learned automatically, the recently developed idea of representative learning (or deep learning) is elegantly employed to extend the existing single-layer self-organizing map background model to a multilayer one (namely, the proposed SMSOM-BM). As a consequence, the SMSOM-BM gains several merits including strong representative ability to learn background model of challenging scenarios, and automatic determination for most network parameters. More specifically, every pixel is modeled by a SMSOM, and spatial consistency is considered at each layer. By introducing a novel over-layer filtering process, we can train the background model layer by layer in an efficient manner. Furthermore, for real-time performance consideration, we have implemented the proposed method using NVIDIA CUDA platform. Comparative experimental results show superior performance of the proposed approach.

  9. Background studies for the MINER Coherent Neutrino Scattering reactor experiment

    NASA Astrophysics Data System (ADS)

    Agnolet, G.; Baker, W.; Barker, D.; Beck, R.; Carroll, T. J.; Cesar, J.; Cushman, P.; Dent, J. B.; De Rijck, S.; Dutta, B.; Flanagan, W.; Fritts, M.; Gao, Y.; Harris, H. R.; Hays, C. C.; Iyer, V.; Jastram, A.; Kadribasic, F.; Kennedy, A.; Kubik, A.; Lang, K.; Mahapatra, R.; Mandic, V.; Marianno, C.; Martin, R. D.; Mast, N.; McDeavitt, S.; Mirabolfathi, N.; Mohanty, B.; Nakajima, K.; Newhouse, J.; Newstead, J. L.; Ogawa, I.; Phan, D.; Proga, M.; Rajput, A.; Roberts, A.; Rogachev, G.; Salazar, R.; Sander, J.; Senapati, K.; Shimada, M.; Soubasis, B.; Strigari, L.; Tamagawa, Y.; Teizer, W.; Vermaak, J. I. C.; Villano, A. N.; Walker, J.; Webb, B.; Wetzel, Z.; Yadavalli, S. A.

    2017-05-01

    The proposed Mitchell Institute Neutrino Experiment at Reactor (MINER) experiment at the Nuclear Science Center at Texas A&M University will search for coherent elastic neutrino-nucleus scattering within close proximity (about 2 m) of a 1 MW TRIGA nuclear reactor core using low threshold, cryogenic germanium and silicon detectors. Given the Standard Model cross section of the scattering process and the proposed experimental proximity to the reactor, as many as 5-20 events/kg/day are expected. We discuss the status of preliminary measurements to characterize the main backgrounds for the proposed experiment. Both in situ measurements at the experimental site and simulations using the MCNP and GEANT4 codes are described. A strategy for monitoring backgrounds during data taking is briefly discussed.

  10. Radon induced surface contaminations in low background experiments

    SciTech Connect

    Pattavina, L.

    2013-08-08

    In neutrinoless double-beta decay and dark matter searches, one of the main issues is to increase the experimental sensitivity through careful material selection and production, minimizing the background contributions. In order to achieve the required, extremely low, counting rates, very stringent requirements must be fulfilled in terms of bulk material radiopurity. As the experimental sensitivity increases, the bulk impurities in the detector components decrease, and surface contaminations start to play an increasingly significant role In fully active detectors, like cryogenic particle detectors, surface contaminations are a critical issue (as shown by the CUORICINO experiment). {sup 222}Rn is by far the most intense source of airborne radioactivity, and if a radio-pure material is exposed to environment where the Radon concentration is not minimized, {sup 210}Pb and {sup 210}Po contaminations can occur. The mechanisms and the dynamics of Radon-induced surface contaminations are reviewed, and specific solutions to prevent and to reject the induced background are presented.

  11. Vlasov simulations of collisionless magnetic reconnection without background density

    NASA Astrophysics Data System (ADS)

    Schmitz, H.; Grauer, R.

    2008-02-01

    A standard starting point for the simulation of collisionless reconnection is the Harris equilibrium which is made up of a current sheet that separates two regions of opposing magnetic field. Magnetohydrodynamic simulations of collisionless reconnection usually include a homogeneous background density for reasons of numerical stability. While, in some cases, this is a realistic assumption, the background density may introduce new effects both due to the more involved structure of the distribution function or due to the fact that the Alfvèn speed remains finite far away from the current sheet. We present a fully kinetic Vlasov simulation of the perturbed Harris equilibrium using a Vlasov code. Parameters are chosen to match the Geospace Environment Modeling (GEM) Magnetic Reconnection Challenge but excluding the background density. This allows to compare with earlier simulations [Schmitz H, Grauer R. Kinetic Vlasov simulations of collisionless magnetic reconnection. Phys Plasmas 2006;13:092309] which include the background density. It is found that the absence of a background density causes the reconnection rate to be higher. On the other hand, the time until the onset of reconnection is hardly affected. Again the off diagonal elements of the pressure tensor are found to be important on the X-line but with modified importance for the individual terms.

  12. Structure of the extended emission in the infrared celestial background

    SciTech Connect

    Price, S.D.

    1986-09-30

    The extended emission in the infrared celestial background may be divided into three main components: the zodiacal background, the large discrete sources in the galaxy, and the interstellar dust. The zodiacal background is due to the thermal reradiation of sunlight absorbed by the dust in the solar system. An earth-orbiting infrared telescope will detect the diffuse emission from this dust in all directions with maximum intensity lying roughly along the ecliptic plane where the density of dust is highest. Structure with scale lengths of 10/sup 0/ was measured in both the visual and infrared; finer structure was detected in the infrared by the Infrared Astronomy Satellite. H II regions, areas of ionized gas mixed with and surrounded by dust, are the brightest discrete objects in the galaxy in the long wavelength infrared re-emitted in the infrared with a range of temperatures characteristic of the thermal equilibrium for the surroundings of the dust. The emission from the interstellar dust produces a filimentary structured background, the infrared cirrus. The observed far-infrared color temperature of about 20-35K for the cirrus is consistent with emission-form graphite and silicate grains which absorb the interstellar radiation field. The much-larger LWIR color temperature is likely due to a greater abundance of sub-micron particles in the interstellar medium and, perhaps, from band emission due to polycyclic aromatic hydrocarbons. These galactic planes have full width at half maxima of about 2/sup 0/.

  13. Background Extraction Using Random Walk Image Fusion.

    PubMed

    Hua, Kai-Lung; Wang, Hong-Cyuan; Yeh, Chih-Hsiang; Cheng, Wen-Huang; Lai, Yu-Chi

    2016-12-23

    It is important to extract a clear background for computer vision and augmented reality. Generally, background extraction assumes the existence of a clean background shot through the input sequence, but realistically, situations may violate this assumption such as highway traffic videos. Therefore, our probabilistic model-based method formulates fusion of candidate background patches of the input sequence as a random walk problem and seeks a globally optimal solution based on their temporal and spatial relationship. Furthermore, we also design two quality measures to consider spatial and temporal coherence and contrast distinctness among pixels as background selection basis. A static background should have high temporal coherence among frames, and thus, we improve our fusion precision with a temporal contrast filter and an optical-flow-based motionless patch extractor. Experiments demonstrate that our algorithm can successfully extract artifact-free background images with low computational cost while comparing to state-of-the-art algorithms.

  14. Experimental evolution.

    PubMed

    Kawecki, Tadeusz J; Lenski, Richard E; Ebert, Dieter; Hollis, Brian; Olivieri, Isabelle; Whitlock, Michael C

    2012-10-01

    Experimental evolution is the study of evolutionary processes occurring in experimental populations in response to conditions imposed by the experimenter. This research approach is increasingly used to study adaptation, estimate evolutionary parameters, and test diverse evolutionary hypotheses. Long applied in vaccine development, experimental evolution also finds new applications in biotechnology. Recent technological developments provide a path towards detailed understanding of the genomic and molecular basis of experimental evolutionary change, while new findings raise new questions that can be addressed with this approach. However, experimental evolution has important limitations, and the interpretation of results is subject to caveats resulting from small population sizes, limited timescales, the simplified nature of laboratory environments, and, in some cases, the potential to misinterpret the selective forces and other processes at work. Copyright © 2012 Elsevier Ltd. All rights reserved.

  15. Effects of background gravity stimuli on gravity-controlled behavior

    NASA Technical Reports Server (NTRS)

    Mccoy, D. F.

    1976-01-01

    Physiological and developmental effects of altered gravity were researched. The stimulus properties of gravity have been found to possess reinforcing and aversive properties. Experimental approaches taken, used animals placed into fields of artificial gravity, in the form of parabolic or spiral centrifuges. Gravity preferences were noted and it was concluded that the psychophysics of gravity and background factors which support these behaviors should be further explored.

  16. Classification of high-energy antiprotons on electrons background based on calorimeter data in PAMELA experiment

    NASA Astrophysics Data System (ADS)

    Dunaeva, O. A.; Alekseev, V. V.; Bogomolov, Yu V.; Lukyanov, A. D.; Malakhov, V. V.; Mayorov, A. G.; Rodenko, S. A.

    2017-01-01

    In modern experimental physics a heterogeneous coordinate-sensitive calorimeters are widely used due to their good characteristics and possibilities to obtain a three-dimensional information of particles interactions. Especially it is important at high-energies when electromagnetic or hadron showers are arise. We propose a quit efficient method to identify antiprotons (positrons) with energies more than 10 GeV on electron (proton) background by calorimeter of such kind. We construct the AdaBoost classifier and SVM to separate particles into two classes, different combinations of energy release along reconstructed particle trajectory were used as feature vector. We test a preliminary version of the method on a calorimeter of the PAMELA magnetic spectrometer. For high-energy particles we got a good quality of classification: it lost about 5 · 10‑2 of antiprotons, and less than 4 · 10‑4 of electrons were classified to antiproton class.

  17. Assessment of Radiation Background Variation for Moving Detection Systems

    SciTech Connect

    Miller, James Christopher; Rennie, John Alan; Toevs, James Waldo; Wallace, Darrin J.; Abhold, Mark Edward

    2015-07-13

    The introduction points out that radiation backgrounds fluctuate across very short distances: factors include geology, soil composition, altitude, building structures, topography, and other manmade structures; and asphalt and concrete can vary significantly over short distances. Brief descriptions are given of the detection system, experimental setup, and background variation measurements. It is concluded that positive and negative gradients can greatly reduce the detection sensitivity of an MDS: negative gradients create opportunities for false negatives (nondetection), and positive gradients create a potentially unacceptable FAR (above 1%); the location of use for mobile detection is important to understand; spectroscopic systems provide more information for screening out false alarms and may be preferred for mobile use; and mobile monitor testing at LANL accounts for expected variations in the background.

  18. Simulating the Background Noise in the LEGRI CZT Detectors

    NASA Astrophysics Data System (ADS)

    Perfect, C. L.; Bird, A. J.; Dean, A. J.; Ferguson, C.; Lei, F.; Lockley, J. J.

    2001-03-01

    A Monte-Carlo model of the MINISAT 01 satellite has been built. This model, based on the GEANT software suite, is used to study the background noise induced in the cadmium zinc telluride (CZT) in the LEGRI detector. We find that the background noise count rate at the poles is ~ 50% higher than at the equator. This increase is due to the effects of geomagnetic rigidity cut-off. We also simulate the effects of passages through the South Atlantic Anomaly (SAA) with simulations showing an increase of ~ 0.5 counts cm^-2 sec^-1 after the SAA, in good agreement with observational data.

  19. Background field functional renormalization group for absorbing state phase transitions.

    PubMed

    Buchhold, Michael; Diehl, Sebastian

    2016-07-01

    We present a functional renormalization group approach for the active to inactive phase transition in directed percolation-type systems, in which the transition is approached from the active, finite density phase. By expanding the effective potential for the density field around its minimum, we obtain a background field action functional, which serves as a starting point for the functional renormalization group approach. Due to the presence of the background field, the corresponding nonperturbative flow equations yield remarkably good estimates for the critical exponents of the directed percolation universality class, even in low dimensions.

  20. The EPIC-MOS Particle-Induced Background Spectrum

    NASA Technical Reports Server (NTRS)

    Kuntz, K. D.; Snowden, S. L.

    2006-01-01

    We have developed a method for constructing a spectrum of the particle-induced instrumental background of the XMM-Newton EPIC MOS detectors that can be used for observations of the diffuse background and extended sources that fill a significant fraction of the instrument field of view. The strength and spectrum of the particle-induced background, that is, the background due to the interaction of particles with the detector and the detector surroundings, is temporally variable as well as spatially variable over individual chips. Our method uses a combination of the filter-wheel-closed data and a database of unexposed-region data to construct a spectrum of the "quiescent" background. We show that, using this method of background subtraction, the differences between independent observations of the same region of "blank sky" are consistent with the statistical uncertainties except when there is clear evidence of solar wind charge exchange emission. We use the blank sky observations to show that contamination by SWCX emission is a strong function of the solar wind proton flux, and that observations through the flanks of the magnetosheath appear to be contaminated only at much higher solar wind fluxes. We have also developed a spectral model of the residual soft proton flares, which allows their effects to be removed to a substantial degree during spectral fitting.

  1. Student criminal background checks in colleges of allied health.

    PubMed

    Wyatt, Diane; Aziz, Hassan; Mahoney, Sherry; Gilman, Frances H

    2008-01-01

    The demand that criminal background checks be performed for students in allied health schools and programs has soared in recent years. The need for criminal background checks on students entering the health care professions has emerged as a critical issue largely due to requirements by clinical affiliate training sites. The Joint Commission published a standard stating, "for staff, students and volunteers who work in the same capacity as staff who provide care, treatment, and services, at Elements of Performance 5 states criminal background checks are verified when required by law and regulation and organization policy." More simply stated, this means that criminal background check records must be verifiable if required by some authoritative entity such as state law. However, whether by misinterpretation of the standard or through conscious decision by organization policy makers, many health care organizations suddenly began to require criminal background checks as part of their affiliation agreements with health related schools or programs. The focus of this study was to identify current practices of allied health institutions regarding their conduct of criminal background checks on students entering the allied health professions.

  2. The research of moving object detection based on background difference compensation

    NASA Astrophysics Data System (ADS)

    Song, Yan-bin; Ying, Jie; Lu, Lin-li

    2013-08-01

    Moving object detection was implemented in dynamic background based on background difference compensation. Background differential can effectively segment the moving object in static background. But in moving video, the camera motion causes corresponding movement of the target and background, which makes the prospect moving object hard to separate from the background. In order to detect moving object, we can compensate the movement of the background and transfer the dynamic background to static. Moving object detection in static background image was implemented using a new weights updating method that the weights were updated during a certain period. This method based on classical Gaussian mixture model improved the efficiency of image segmentation greatly. Moving object detection in dynamic background was realized using background differential compensation. The global motion of the background was established according to the affined parameters model. The model parameters were estimated by feature points matching based on the search strategy. Invalid matching points were eliminated using the method of distance consistency. Backward mapping was used to get the motion parameters of the background. After compensation of the background with the global motion parameters, frame difference between the current frame and the background can detect moving objects effectively. Experiments were done on computer with the programming tools of VS2010 and MATLAB. Experimental results showed that the algorithm based on differential compensation was effective.

  3. Generalized duality in curved string backgrounds

    NASA Astrophysics Data System (ADS)

    Giveon, Amit; Roček, Martin

    1992-08-01

    The elements of O(d, d, Z) are shown to be discrete symmetries of the space of curved string backgrounds that are independent of d coordinates. The explicit action of the symmetries on the backgrounds is described. Particular attention is paid to the dilaton transformation. Such symmetries identify different cosmological solutions and other (possibly) singular backgrounds; for example, it is shown that a compact black string is dual to a charged black hole. The extension to the heterotic string is discussed.

  4. Cosmic Background Explorer (COBE) press kit

    NASA Technical Reports Server (NTRS)

    1989-01-01

    COBE, the Cosmic Background Explorer spacecraft, and its mission are described. COBE was designed to study the origin and dynamics of the universe including the theory that the universe began with a cataclysmic explosion referred to as the Big Bang. To this end, earth's cosmic background - the infrared radiation that bombards earth from every direction - will be measured by three sophisticated instruments: the Differential Microwave Radiometer (DMR), the Far Infrared Absolute Spectrophotometer (FIRAS), and the Diffuse Infrared Background Experiment (DIRBE).

  5. Firearm Acquisition Without Background Checks: Results of a National Survey.

    PubMed

    Miller, Matthew; Hepburn, Lisa; Azrael, Deborah

    2017-02-21

    In 1994, 40% of U.S. gun owners who had recently acquired a firearm did so without a background check. No contemporary estimates exist. To estimate the proportion of current U.S. gun owners who acquired their most recent firearm without a background check, by time since and manner of acquisition, for the nation as a whole and separately in states with and without legislation regulating private sales. Probability-based online survey. United States, 2015. 1613 adult gun owners. Current gun owners were asked where and when they acquired their last firearm; if they purchased the firearm; and whether, as part of that acquisition, they had a background check (or were asked to show a firearm license or permit). 22% (95% CI, 16% to 27%) of gun owners who reported obtaining their most recent firearm within the previous 2 years reported doing so without a background check. For firearms purchased privately within the previous 2 years (that is, other than from a store or pawnshop, including sales between individuals in person, online, or at gun shows), 50% (CI, 35% to 65%) were obtained without a background check. This percentage was 26% (CI, 5% to 47%) for owners residing in states regulating private firearm sales and 57% (CI, 40% to 75%) for those living in states without regulations on private firearm sales. Potential inaccuracies due to recall and social desirability bias. 22% of current U.S. gun owners who acquired a firearm within the past 2 years did so without a background check. Although this represents a smaller proportion of gun owners obtaining firearms without background checks than in the past, millions of U.S. adults continue to acquire guns without background checks, especially in states that do not regulate private firearm sales. Fund for a Safer Future and the Joyce Foundation.

  6. Technology Development for Cosmic Microwave Background Cosmology

    NASA Astrophysics Data System (ADS)

    Munson, Charles D.

    2017-05-01

    The Cosmic Microwave Background (CMB) offers a unique window into the early universe by probing thermal radiation remaining from the big bang. Due to its low temperature and bright foregrounds, its thorough characterization requires technological advancement beyond the current state-of-the-art. In this thesis, I present the development and fabrication of novel metamaterial silicon optics to improve the sensitivity of current and future CMB telescopes. By machining subwavelength features into the silicon surfaces, traditional antireflection coatings can be replaced by all-silicon metamaterials that significantly reduce reflections over previous approaches. I discuss the design of these structured surfaces and the design and construction of a sophisticated fabrication facility necessary to implement this technology on large diameter (30+ cm) lenses for the Atacama Cosmology Telescope Polarization project (ACTPol). I then apply this metamaterial technology to the development of improved free-space filters for millimeter and sub-millimeter wavelength imaging (focusing specifically on blocking infrared radiation, necessary for current cryogenic detector systems). This produces a highly effective infrared-blocking filter, blocking over 99% of the incident power from a 300 K blackbody while maintaining transmission of better than 99% in a target CMB observing band (between 70 and 170 GHz). I conclude with a discussion of the development of a real-space simulation framework to assist in better understanding current CMB results and forecasting for future experiments. By taking a CMB realization and adding to it accurate real-space modeling of the Sunyaev-Zel'dovich effect and weak lensing distortions (introduced by galaxy clusters), a better understanding of the impacts of large scale structure on the CMB can be obtained.

  7. Near-Earth Object (NEO) Hazard Background

    NASA Technical Reports Server (NTRS)

    Mazanek, Daniel D.

    2005-01-01

    The fundamental problem regarding NEO hazards is that the Earth and other planets, as well as their moons, share the solar system with a vast number of small planetary bodies and orbiting debris. Objects of substantial size are typically classified as either comets or asteroids. Although the solar system is quite expansive, the planets and moons (as well as the Sun) are occasionally impacted by these objects. We live in a cosmic shooting gallery where collisions with Earth occur on a regular basis. Because the number of smaller comets and asteroids is believed to be much greater than larger objects, the frequency of impacts is significantly higher. Fortunately, the smaller objects, which are much more numerous, are usually neutralized by the Earth's protective atmosphere. It is estimated that between 1000 and 10,000 tons of debris fall to Earth each year, most of it in the form of dust particles and extremely small meteorites. With no atmosphere, the Moon's surface is continuously impacted with dust and small debris. On November 17 and 18, 1999, during the annual Leonid meteor shower, several lunar surface impacts were observed by amateur astronomers in North America. The Leonids result from the Earth's passage each year through the debris ejected from Comet Tempel-Tuttle. These annual showers provide a periodic reminder of the possibility of a much more consequential cosmic collision, and the heavily cratered lunar surface acts a constant testimony to the impact threat. The impact problem and those planetary bodies that are a threat have been discussed in great depth in a wide range of publications and books, such as The Spaceguard Survey , Hazards Due to Comets and Asteroids, and Cosmic Catastrophes. This paper gives a brief overview on the background of this problem and address some limitations of ground-based surveys for detection of small and/or faint near-Earth objects.

  8. Technology Development for Cosmic Microwave Background Cosmology

    NASA Astrophysics Data System (ADS)

    Munson, Charles D.

    The Cosmic Microwave Background (CMB) offers a unique window into the early universe by probing thermal radiation remaining from the big bang. Due to its low temperature and bright foregrounds, its thorough characterization requires technological advancement beyond the current state-of-the-art. In this thesis, I present the development and fabrication of novel metamaterial silicon optics to improve the sensitivity of current and future CMB telescopes. By machining subwavelength features into the silicon surfaces, traditional antireflection coatings can be replaced by all-silicon metamaterials that significantly reduce reflections over previous approaches. I discuss the design of these structured surfaces and the design and construction of a sophisticated fabrication facility necessary to implement this technology on large diameter (30+ cm) lenses for the Atacama Cosmology Telescope Polarization project (ACTPol). I then apply this metamaterial technology to the development of improved free-space filters for millimeter and sub-millimeter wavelength imaging (focusing specifically on blocking infrared radiation, necessary for current cryogenic detector systems). This produces a highly effective infrared-blocking filter, blocking over 99% of the incident power from a 300 K blackbody while maintaining transmission of better than 99% in a target CMB observing band (between 70 and 170 GHz). I conclude with a discussion of the development of a real-space simulation framework to assist in better understanding current CMB results and forecasting for future experiments. By taking a CMB realization and adding to it accurate real-space modeling of the Sunyaev-Zel'dovich effect and weak lensing distortions (introduced by galaxy clusters), a better understanding of the impacts of large scale structure on the CMB can be obtained.

  9. Physical Activity and School Absenteeism Due to Illness in Adolescents

    ERIC Educational Resources Information Center

    de Groot, Renate; van Dijk, Martin; Savelberg, Hans; van Acker, Frederik; Kirschner, Paul

    2017-01-01

    Background: Knowledge about the beneficial role of physical activity (PA) for health and school performance is growing. Studies investigating the link between PA and school absenteeism due to illness are lacking. Therefore, we investigated associations between habitual PA and school absenteeism due to illness in adolescents and explored whether…

  10. Ultra-low background measurements of decayed aerosol filters.

    PubMed

    Aalseth, Craig; Andreotti, Erica; Arnold, Dirk; Cabeza, Joan-Albert Sanchez; Degering, Detlev; Giuliani, Andrea; de Orduña, Raquel Gonzales; Gurriaran, Rodolfo; Hult, Mikael; Keillor, Martin; Laubenstein, Matthias; le Petit, Gilbert; Margineanu, Romul Mircea; Matthews, Murray; Miley, Harry; Osvath, Iolanda; Pellicciari, Monica; Plastino, Wolfango; Simgen, Hardy; Weber, Marc; Werzi, Robert

    Aerosol samples collected on filter media were analyzed using HPGe detectors employing varying background-reduction techniques in order to experimentally evaluate the opportunity to apply ultra-low background measurement methods to samples collected, for instance, by the Comprehensive Test Ban Treaty International Monitoring System (IMS). In this way, realistic estimates of the impact of low-background methodology on the sensitivity obtained in systems such as the IMS were assessed. The current detectability requirement of stations in the IMS is 30 μBq/m(3) of air for (140)Ba, which would imply ~10(6) fissions per daily sample. Importantly, this is for a fresh aerosol filter. One week of decay reduces the intrinsic background from radon daughters in the sample allowing much higher sensitivity measurement of relevant isotopes, including (131)I. An experiment was conducted in which decayed filter samples were measured at a variety of underground locations using Ultra-Low Background (ULB) gamma spectroscopy technology. The impacts of the decay and ULB are discussed.

  11. Cleaning procedure for improved photothermal background of toroidal optical microresonators

    NASA Astrophysics Data System (ADS)

    Horak, Erik H.; Knapper, Kassandra A.; Heylman, Kevin D.; Goldsmith, Randall H.

    2016-09-01

    High Q-factors and small mode volumes have made toroidal optical microresonators exquisite sensors to small shifts in the effective refractive index of the WGM modes. Eliminating contaminants and improving quality factors is key for many different sensing techniques, and is particularly important for photothermal imaging as contaminants add photothermal background obscuring objects of interest. Several different cleaning procedures including wet- and dry-chemical procedures are tested for their effect on Q-factors and photothermal background. RCA cleaning was shown to be successful in contrast to previously described acid cleaning procedures, most likely due to the different surface reactivity of the acid reagents used. UV-ozone cleaning was shown to be vastly superior to O2 plasma cleaning procedures, significantly reducing the photothermal background of the resonator.

  12. Hanford Site background: Part 1, Soil background for nonradioactive analytes. Revision 1, Volume 2

    SciTech Connect

    Not Available

    1993-04-01

    Volume two contains the following appendices: Description of soil sampling sites; sampling narrative; raw data soil background; background data analysis; sitewide background soil sampling plan; and use of soil background data for the detection of contamination at waste management unit on the Hanford Site.

  13. Background check for anomalous like-sign dimuon charge asymmetry

    SciTech Connect

    Gronau, Michael; Rosner, Jonathan L.

    2010-10-01

    The D0 Collaboration has reported an excess of roughly 1% of {mu}{sup -{mu}-} pairs over {mu}{sup +{mu}+} pairs in pp collisions at a center-of-mass energy {radical}(s)=1.96 GeV at the Fermilab Tevatron, when known backgrounds are subtracted. This excess, if ascribed to CP violation in meson-antimeson mixing of nonstrange or strange neutral B mesons, is about 40 times that expected in the standard model. We propose a null test, based on a tight restriction on the muon impact parameter b, to confirm that this excess is indeed due to B mesons. If the asymmetry is due to anomalous CP violation in B{sub s}-B{sub s} mixing, then a tight restriction on b would increase by a factor 2 the net asymmetry from neutral B mixing, while the sample of dimuons from neutral B decays will be reduced significantly relative to background events.

  14. Climatic influence of background and volcanic stratosphere aerosol models

    NASA Technical Reports Server (NTRS)

    Deschamps, P. Y.; Herman, M.; Lenoble, J.; Tanre, D.

    1982-01-01

    A simple modelization of the earth atmosphere system including tropospheric and stratospheric aerosols has been derived and tested. Analytical expressions are obtained for the albedo variation due to a thin stratospheric aerosol layer. Also outlined are the physical procedures and the respective influence of the main parameters: aerosol optical thickness, single scattering albedo and asymmetry factor, and sublayer albedo. The method is applied to compute the variation of the zonal and planetary albedos due to a stratospheric layer of background H2SO4 particles and of volcanic ash.

  15. Cutting Balloon: Review on Principles and Background of Use in Peripheral Arteries

    SciTech Connect

    Cejna, Manfred

    2005-05-15

    This review describes peripheral use of cutting balloon (CB) angioplasty (CBA), its characteristics, and its distinction from conventional BA and describes the experimental and clinical background of its current use in peripheral arteries.

  16. Primary and Secondary Anisotropies of Cosmic Microwave Background

    NASA Technical Reports Server (NTRS)

    Seljak, Uros

    2002-01-01

    The three main topics we proposed to do are linear calculations (continuing development of CMBFAST), nonlinear calculations of gas physics relevant to Cosmic Microwave Background (CMB) (Sunyaev-Zeldovich effect, etc.) and nonlinear effects on CMB due to dark matter (gravitational lensing, etc.). We describe each of these topics, as well as additional topics PI and his group worked on that are related to the topics in the proposal.

  17. Method and apparatus for reducing solvent luminescence background emissions

    DOEpatents

    Affleck, Rhett L.; Ambrose, W. Patrick; Demas, James N.; Goodwin, Peter M.; Johnson, Mitchell E.; Keller, Richard A.; Petty, Jeffrey T.; Schecker, Jay A.; Wu, Ming

    1998-01-01

    The detectability of luminescent molecules in solution is enhanced by reducing the background luminescence due to impurity species also present in the solution. A light source that illuminates the solution acts to photolyze the impurities so that the impurities do not luminesce in the fluorescence band of the molecule of interest. Molecules of interest may be carried through the photolysis region in the solution or may be introduced into the solution after the photolysis region.

  18. Method and apparatus for reducing solvent luminescence background emissions

    DOEpatents

    Affleck, R.L.; Ambrose, W.P.; Demas, J.N.; Goodwin, P.M.; Johnson, M.E.; Keller, R.A.; Petty, J.T.; Schecker, J.A.; Wu, M.

    1998-10-27

    The detectability of luminescent molecules in solution is enhanced by reducing the background luminescence due to impurity species also present in the solution. A light source that illuminates the solution acts to photolyze the impurities so that the impurities do not luminesce in the fluorescence band of the molecule of interest. Molecules of interest may be carried through the photolysis region in the solution or may be introduced into the solution after the photolysis region. 6 figs.

  19. 45 CFR 650.16 - Background rights.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 45 Public Welfare 3 2012-10-01 2012-10-01 false Background rights. 650.16 Section 650.16 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL SCIENCE FOUNDATION PATENTS § 650.16 Background rights. The Foundation will acquire rights to a research performer's pre-existing technology...

  20. 47 CFR 201.0 - Background.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 47 Telecommunication 5 2013-10-01 2013-10-01 false Background. 201.0 Section 201.0 Telecommunication OFFICE OF SCIENCE AND TECHNOLOGY POLICY AND NATIONAL SECURITY COUNCIL EXECUTIVE POLICY § 201.0 Background. National policy with respect to the conservation, allocation and use of the...

  1. 47 CFR 201.0 - Background.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 5 2014-10-01 2014-10-01 false Background. 201.0 Section 201.0 Telecommunication OFFICE OF SCIENCE AND TECHNOLOGY POLICY AND NATIONAL SECURITY COUNCIL EXECUTIVE POLICY § 201.0 Background. National policy with respect to the conservation, allocation and use of the...

  2. Multiple Scatters in Single Site Gamma Backgrounds

    SciTech Connect

    Brodsky, J. P.

    2016-09-16

    nEXO aims to reduce its gamma backgrounds by taking advantage of the fact that a large number of gammas that would otherwise be backgrounds will undergo multiple compton scattering in the TPC and produce spatially distinct signals. These multi-sited (MS) events can be excluded from the 0νββ search.

  3. 47 CFR 32.1 - Background.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 47 Telecommunication 2 2012-10-01 2012-10-01 false Background. 32.1 Section 32.1 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES UNIFORM SYSTEM OF ACCOUNTS FOR TELECOMMUNICATIONS COMPANIES Preface § 32.1 Background. The revised Uniform System of Accounts (USOA) is a...

  4. 47 CFR 32.1 - Background.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 2 2014-10-01 2014-10-01 false Background. 32.1 Section 32.1 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES UNIFORM SYSTEM OF ACCOUNTS FOR TELECOMMUNICATIONS COMPANIES Preface § 32.1 Background. The revised Uniform System of Accounts (USOA) is a...

  5. 47 CFR 32.1 - Background.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 47 Telecommunication 2 2013-10-01 2013-10-01 false Background. 32.1 Section 32.1 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES UNIFORM SYSTEM OF ACCOUNTS FOR TELECOMMUNICATIONS COMPANIES Preface § 32.1 Background. The revised Uniform System of Accounts (USOA) is a...

  6. 40 CFR 761.380 - Background.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 31 2011-07-01 2011-07-01 false Background. 761.380 Section 761.380 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT....380 Background. This subpart provides self-implementing criteria for validating the conditions for...

  7. 32 CFR 763.3 - Background.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 5 2011-07-01 2011-07-01 false Background. 763.3 Section 763.3 National Defense Department of Defense (Continued) DEPARTMENT OF THE NAVY ISLANDS UNDER NAVY JURISDICTION RULES GOVERNING PUBLIC ACCESS Entry Regulations for Kaho'olawe Island, Hawaii § 763.3 Background. (a) Kaho'olawe Island...

  8. 32 CFR 763.3 - Background.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 5 2010-07-01 2010-07-01 false Background. 763.3 Section 763.3 National Defense Department of Defense (Continued) DEPARTMENT OF THE NAVY ISLANDS UNDER NAVY JURISDICTION RULES GOVERNING PUBLIC ACCESS Entry Regulations for Kaho'olawe Island, Hawaii § 763.3 Background. (a) Kaho'olawe Island...

  9. 47 CFR 201.0 - Background.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 5 2011-10-01 2011-10-01 false Background. 201.0 Section 201.0 Telecommunication OFFICE OF SCIENCE AND TECHNOLOGY POLICY AND NATIONAL SECURITY COUNCIL EXECUTIVE POLICY § 201.0 Background. National policy with respect to the conservation, allocation and use of the...

  10. 47 CFR 201.0 - Background.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 47 Telecommunication 5 2012-10-01 2012-10-01 false Background. 201.0 Section 201.0 Telecommunication OFFICE OF SCIENCE AND TECHNOLOGY POLICY AND NATIONAL SECURITY COUNCIL EXECUTIVE POLICY § 201.0 Background. National policy with respect to the conservation, allocation and use of the...

  11. 32 CFR 732.1 - Background.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 5 2011-07-01 2011-07-01 false Background. 732.1 Section 732.1 National Defense Department of Defense (Continued) DEPARTMENT OF THE NAVY PERSONNEL NONNAVAL MEDICAL AND DENTAL CARE General § 732.1 Background. When a U.S. Navy or Marine Corps member or a Canadian Navy or Marine Corps member...

  12. 32 CFR 732.1 - Background.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 5 2013-07-01 2013-07-01 false Background. 732.1 Section 732.1 National Defense Department of Defense (Continued) DEPARTMENT OF THE NAVY PERSONNEL NONNAVAL MEDICAL AND DENTAL CARE General § 732.1 Background. When a U.S. Navy or Marine Corps member or a Canadian Navy or Marine Corps member...

  13. 32 CFR 732.1 - Background.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 5 2012-07-01 2012-07-01 false Background. 732.1 Section 732.1 National Defense Department of Defense (Continued) DEPARTMENT OF THE NAVY PERSONNEL NONNAVAL MEDICAL AND DENTAL CARE General § 732.1 Background. When a U.S. Navy or Marine Corps member or a Canadian Navy or Marine Corps member...

  14. 32 CFR 732.1 - Background.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 5 2014-07-01 2014-07-01 false Background. 732.1 Section 732.1 National Defense Department of Defense (Continued) DEPARTMENT OF THE NAVY PERSONNEL NONNAVAL MEDICAL AND DENTAL CARE General § 732.1 Background. When a U.S. Navy or Marine Corps member or a Canadian Navy or Marine Corps member...

  15. 47 CFR 201.0 - Background.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 5 2010-10-01 2010-10-01 false Background. 201.0 Section 201.0 Telecommunication OFFICE OF SCIENCE AND TECHNOLOGY POLICY AND NATIONAL SECURITY COUNCIL EXECUTIVE POLICY § 201.0 Background. National policy with respect to the conservation, allocation and use of the...

  16. Child Care: State Requirements for Background Checks.

    ERIC Educational Resources Information Center

    Fagnoni, Cynthia

    Background checks involve gathering information from state and federal databases to determine if child care providers have a history of child abuse or other criminal convictions that would make them unacceptable for working with children. Background checks include state criminal history checks, state child abuse registry checks, and Federal Bureau…

  17. 36 CFR 401.3 - Background.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 36 Parks, Forests, and Public Property 3 2012-07-01 2012-07-01 false Background. 401.3 Section 401.3 Parks, Forests, and Public Property AMERICAN BATTLE MONUMENTS COMMISSION MONUMENTS AND MEMORIALS § 401.3 Background. Following World War I many American individuals, organizations and governmental...

  18. 36 CFR 401.3 - Background.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 36 Parks, Forests, and Public Property 3 2014-07-01 2014-07-01 false Background. 401.3 Section 401.3 Parks, Forests, and Public Property AMERICAN BATTLE MONUMENTS COMMISSION MONUMENTS AND MEMORIALS § 401.3 Background. Following World War I many American individuals, organizations and governmental...

  19. 36 CFR § 401.3 - Background.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 36 Parks, Forests, and Public Property 3 2013-07-01 2012-07-01 true Background. § 401.3 Section § 401.3 Parks, Forests, and Public Property AMERICAN BATTLE MONUMENTS COMMISSION MONUMENTS AND MEMORIALS § 401.3 Background. Following World War I many American individuals, organizations and governmental...

  20. 22 CFR 305.3 - Background investigations.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 22 Foreign Relations 2 2014-04-01 2014-04-01 false Background investigations. 305.3 Section 305.3 Foreign Relations PEACE CORPS ELIGIBILITY AND STANDARDS FOR PEACE CORPS VOLUNTEER SERVICE § 305.3 Background investigations. Section 22 of the Peace Corps Act states that to ensure enrollment of a Volunteer...

  1. 22 CFR 305.3 - Background investigations.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 22 Foreign Relations 2 2013-04-01 2009-04-01 true Background investigations. 305.3 Section 305.3 Foreign Relations PEACE CORPS ELIGIBILITY AND STANDARDS FOR PEACE CORPS VOLUNTEER SERVICE § 305.3 Background investigations. Section 22 of the Peace Corps Act states that to ensure enrollment of a Volunteer...

  2. 40 CFR 761.380 - Background.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Background. 761.380 Section 761.380... POLYCHLORINATED BIPHENYLS (PCBs) MANUFACTURING, PROCESSING, DISTRIBUTION IN COMMERCE, AND USE PROHIBITIONS....380 Background. This subpart provides self-implementing criteria for validating the conditions for use...

  3. Women's Health Initiative (WHI) Background and Overview

    MedlinePlus

    ... chronic diseases are the major causes of death, disability and frailty in older women of all races and socioeconomic backgrounds. This multi- ... CDC), and the National Institutes of Health. Eight University-based Prevention ... encouraged women of all races and socioeconomic backgrounds to adopt ...

  4. 32 CFR 732.1 - Background.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 5 2010-07-01 2010-07-01 false Background. 732.1 Section 732.1 National Defense Department of Defense (Continued) DEPARTMENT OF THE NAVY PERSONNEL NONNAVAL MEDICAL AND DENTAL CARE General § 732.1 Background. When a U.S. Navy or Marine Corps member or a Canadian Navy or Marine Corps member...

  5. Simulation of background reduction and Compton suppression in a low-background HPGe spectrometer at a surface laboratory

    NASA Astrophysics Data System (ADS)

    Niu, Shun-Li; Cai, Xiao; Wu, Zhen-Zhong; Liu, Yi; Xie, Yu-Guang; Yu, Bo-Xiang; Wang, Zhi-Gang; Fang, Jian; Sun, Xi-Lei; Sun, Li-Jun; Liu, Ying-Biao; Gao, Long; Zhang, Xuan; Zhao, Hang; Zhou, Li; Lü, Jun-Guang; Hu, Tao

    2015-08-01

    High-purity germanium (HPGe) detectors are well suited to analyse the radioactivity of samples. In order to reduce the environmental background for an ultra-low background HPGe spectrometer, low-activity lead and oxygen free copper are installed outside the probe to shield from gamma radiation, with an outer plastic scintillator to veto cosmic rays, and an anti-Compton detector to improve the peak-to-Compton ratio. Using Geant4 tools and taking into account a detailed description of the detector, we optimize the sizes of these detectors to reach the design requirements. A set of experimental data from an existing HPGe spectrometer was used to compare with the simulation. For the future low-background HPGe detector simulation, considering different thicknesses of BGO crystals and anti-coincidence efficiency, the simulation results show that the optimal BGO thickness is 5.5 cm, and the peak-to-Compton ratio of 40K is raised to 1000 when the anti-coincidence efficiency is 0.85. In the background simulation, 15 cm oxygen-free copper plus 10 cm lead can reduce the environmental gamma rays to 0.0024 cps/100 cm3 Ge (50 keV-2.8 MeV), which is about 10-5 of the environmental background.

  6. Experimental Pi.

    ERIC Educational Resources Information Center

    Corris, G.

    1990-01-01

    Discusses the calculation of pi by means of experimental methods. Polygon circle ratios, Archimedes' method, Buffon's needles, a Monte Carlo method, and prime number approaches are used. Presents three BASIC programs for the calculations. (YP)

  7. Experimental Pi.

    ERIC Educational Resources Information Center

    Corris, G.

    1990-01-01

    Discusses the calculation of pi by means of experimental methods. Polygon circle ratios, Archimedes' method, Buffon's needles, a Monte Carlo method, and prime number approaches are used. Presents three BASIC programs for the calculations. (YP)

  8. Spatial variations of groundwater background concentrations in coastal aquifers, Korea

    NASA Astrophysics Data System (ADS)

    Hyun, Yunjung; Lee, Soojae

    2014-05-01

    In coastal aquifers the mixing between fresh terrestrial water and seawater occurs, which influences groundwater quality. Due to mixing elevated chloride concentrations are often observed in coastal aquifers. In coastal areas terrestrial water-seawater mixing can be caused by anthropogenic activities or natural factors such as tides and sea level changes. Therefore, it is difficult or even impossible to characterize groundwater background concentrations in coastal aquifers. Although it is usual to exclude coastal aquifer when characterizing background concentrations, it is essential to accurately characterize naturally-affected groundwater quality in coastal areas because groundwater is a major water resource for potable, irrigation, domestic uses. So in this work we define groundwater background concentrations as naturally occurring ambient concentrations with excluding groundwater abstraction. Based on this definition, we evaluate groundwater background concentrations in various geologic formations and analyze characteristics of groundwater quality in coastal aquifers by utilizing Groundwater Quality Monitoring System (GQMS) data. The results show that high concentrations of chloride are observed in some coastal areas but not always. Tidal effects and topographical characteristics are thought to be as factors affecting such spatial variations. In some coastal areas high concentrations of chloride are observed with high nitrate concentrations. This means that agricultural practices can attribute to anthropogenic background, leading to elevated concentrations of nitrate. These results provide some essential information for groundwater resources management in coastal areas. Further data collection and analysis is required for evaluating the effect of tide and sea level changes on groundwater quality.

  9. Low-background Gamma Spectroscopy at Sanford Underground Laboratory

    NASA Astrophysics Data System (ADS)

    Chiller, Christopher; Alanson, Angela; Mei, Dongming

    2014-03-01

    Rare-event physics experiments require the use of material with unprecedented radio-purity. Low background counting assay capabilities and detectors are critical for determining the sensitivity of the planned ultra-low background experiments. A low-background counting, LBC, facility has been built at the 4850-Level Davis Campus of the Sanford Underground Research Facility to perform screening of material and detector parts. Like many rare event physics experiments, our LBC uses lead shielding to mitigate background radiation. Corrosion of lead brick shielding in subterranean installations creates radon plate-out potential as well as human risks of ingestible or respirable lead compounds. Our LBC facilities employ an exposed lead shield requiring clean smooth surfaces. A cleaning process of low-activity silica sand blasting and borated paraffin hot coating preservation was employed to guard against corrosion due to chemical and biological exposures. The resulting lead shield maintains low background contribution integrity while fully encapsulating the lead surface. We report the performance of the current LBC and a plan to develop a large germanium well detector for PMT screening. Support provided by Sd governors research center-CUBED, NSF PHY-0758120 and Sanford Lab.

  10. Intense ion beam neutralization using underdense background plasma

    SciTech Connect

    Berdanier, William; Roy, Prabir K.; Kaganovich, Igor

    2015-01-15

    Producing an overdense background plasma for neutralization purposes with a density that is high compared to the beam density is not always experimentally possible. We show that even an underdense background plasma with a small relative density can achieve high neutralization of intense ion beam pulses. Using particle-in-cell simulations, we show that if the total plasma electron charge is not sufficient to neutralize the beam charge, electron emitters are necessary for effective neutralization but are not needed if the plasma volume is so large that the total available charge in the electrons exceeds that of the ion beam. Several regimes of possible underdense/tenuous neutralization plasma densities are investigated with and without electron emitters or dense plasma at periphery regions, including the case of electron emitters without plasma, which does not effectively neutralize the beam. Over 95% neutralization is achieved for even very underdense background plasma with plasma density 1/15th the beam density. We compare results of particle-in-cell simulations with an analytic model of neutralization and find close agreement with the particle-in-cell simulations. Further, we show experimental data from the National Drift Compression experiment-II group that verifies the result that underdense plasma can neutralize intense heavy ion beams effectively.

  11. Experimental Demonstration of Underwater Acoustic Scattering Cancellation

    NASA Astrophysics Data System (ADS)

    Rohde, Charles A.; Martin, Theodore P.; Guild, Matthew D.; Layman, Christopher N.; Naify, Christina J.; Nicholas, Michael; Thangawng, Abel L.; Calvo, David C.; Orris, Gregory J.

    2015-08-01

    We explore an acoustic scattering cancellation shell for buoyant hollow cylinders submersed in a water background. A thin, low-shear, elastic coating is used to cancel the monopole scattering from an air-filled, neutrally buoyant steel shell for all frequencies where the wavelength is larger than the object diameter. By design, the uncoated shell also has an effective density close to the aqueous background, independently canceling its dipole scattering. Due to the significantly reduced monopole and dipole scattering, the compliant coating results in a hollow cylindrical inclusion that is simultaneously impedance and sound speed matched to the water background. We demonstrate the proposed cancellation method with a specific case, using an array of hollow steel cylinders coated with thin silicone rubber shells. These experimental results are matched to finite element modeling predictions, confirming the scattering reduction. Additional calculations explore the optimization of the silicone coating properties. Using this approach, it is found that scattering cross-sections can be reduced by 20 dB for all wavelengths up to k0a = 0.85.

  12. Experimental Demonstration of Underwater Acoustic Scattering Cancellation

    PubMed Central

    Rohde, Charles A.; Martin, Theodore P.; Guild, Matthew D.; Layman, Christopher N.; Naify, Christina J.; Nicholas, Michael; Thangawng, Abel L.; Calvo, David C.; Orris, Gregory J.

    2015-01-01

    We explore an acoustic scattering cancellation shell for buoyant hollow cylinders submersed in a water background. A thin, low-shear, elastic coating is used to cancel the monopole scattering from an air-filled, neutrally buoyant steel shell for all frequencies where the wavelength is larger than the object diameter. By design, the uncoated shell also has an effective density close to the aqueous background, independently canceling its dipole scattering. Due to the significantly reduced monopole and dipole scattering, the compliant coating results in a hollow cylindrical inclusion that is simultaneously impedance and sound speed matched to the water background. We demonstrate the proposed cancellation method with a specific case, using an array of hollow steel cylinders coated with thin silicone rubber shells. These experimental results are matched to finite element modeling predictions, confirming the scattering reduction. Additional calculations explore the optimization of the silicone coating properties. Using this approach, it is found that scattering cross-sections can be reduced by 20 dB for all wavelengths up to k0a = 0.85. PMID:26282067

  13. The Anisotropy of the Microwave Background to l=3500: Mosaic Observations with the Cosmic Background Imager

    NASA Technical Reports Server (NTRS)

    Pearson, T. J.; Mason, B. S.; Readhead, A. C. S.; Shepherd, M. C.; Sievers, J. L.; Udomprasert, P. S.; Cartwright, J. K.; Farmer, A. J.; Padin, S.; Myers, S. T.; Six, N. Frank (Technical Monitor)

    2002-01-01

    Using the Cosmic Background Imager, a 13-element interferometer array operating in the 26-36 GHz frequency band, we have observed 40 deg (sup 2) of sky in three pairs of fields, each approximately 145 feet x 165 feet, using overlapping pointings: (mosaicing). We present images and power spectra of the cosmic microwave background radiation in these mosaic fields. We remove ground radiation and other low-level contaminating signals by differencing matched observations of the fields in each pair. The primary foreground contamination is due to point sources (radio galaxies and quasars). We have subtracted the strongest sources from the data using higher-resolution measurements, and we have projected out the response to other sources of known position in the power-spectrum analysis. The images show features on scales approximately 6 feet-15 feet, corresponding to masses approximately 5-80 x 10(exp 14) solar mass at the surface of last scattering, which are likely to be the seeds of clusters of galaxies. The power spectrum estimates have a resolution delta l approximately 200 and are consistent with earlier results in the multipole range l approximately less than 1000. The power spectrum is detected with high signal-to-noise ratio in the range 300 approximately less than l approximately less than 1700. For 1700 approximately less than l approximately less than 3000 the observations are consistent with the results from more sensitive CBI deep-field observations. The results agree with the extrapolation of cosmological models fitted to observations at lower l, and show the predicted drop at high l (the "damping tail").

  14. The Anisotropy of the Microwave Background to l=3500: Mosaic Observations with the Cosmic Background Imager

    NASA Technical Reports Server (NTRS)

    Pearson, T. J.; Mason, B. S.; Readhead, A. C. S.; Shepherd, M. C.; Sievers, J. L.; Udomprasert, P. S.; Cartwright, J. K.; Farmer, A. J.; Padin, S.; Myers, S. T.; hide

    2002-01-01

    Using the Cosmic Background Imager, a 13-element interferometer array operating in the 26-36 GHz frequency band, we have observed 40 deg (sup 2) of sky in three pairs of fields, each approximately 145 feet x 165 feet, using overlapping pointings: (mosaicing). We present images and power spectra of the cosmic microwave background radiation in these mosaic fields. We remove ground radiation and other low-level contaminating signals by differencing matched observations of the fields in each pair. The primary foreground contamination is due to point sources (radio galaxies and quasars). We have subtracted the strongest sources from the data using higher-resolution measurements, and we have projected out the response to other sources of known position in the power-spectrum analysis. The images show features on scales approximately 6 feet-15 feet, corresponding to masses approximately 5-80 x 10(exp 14) solar mass at the surface of last scattering, which are likely to be the seeds of clusters of galaxies. The power spectrum estimates have a resolution delta l approximately 200 and are consistent with earlier results in the multipole range l approximately less than 1000. The power spectrum is detected with high signal-to-noise ratio in the range 300 approximately less than l approximately less than 1700. For 1700 approximately less than l approximately less than 3000 the observations are consistent with the results from more sensitive CBI deep-field observations. The results agree with the extrapolation of cosmological models fitted to observations at lower l, and show the predicted drop at high l (the "damping tail").

  15. Sources of the Radio Background Considered

    SciTech Connect

    Singal, J.; Stawarz, L.; Lawrence, A.; Petrosian, V.; /KIPAC, Menlo Park /Stanford U., Phys. Dept. /Stanford U., Appl. Phys. Dept.

    2011-08-22

    We investigate possible origins of the extragalactic radio background reported by the ARCADE 2 collaboration. The surface brightness of the background is several times higher than that which would result from currently observed radio sources. We consider contributions to the background from diffuse synchrotron emission from clusters and the intergalactic medium, previously unrecognized flux from low surface brightness regions of radio sources, and faint point sources below the flux limit of existing surveys. By examining radio source counts available in the literature, we conclude that most of the radio background is produced by radio point sources that dominate at sub {mu}Jy fluxes. We show that a truly diffuse background produced by elections far from galaxies is ruled out because such energetic electrons would overproduce the observed X-ray/{gamma}-ray background through inverse Compton scattering of the other photon fields. Unrecognized flux from low surface brightness regions of extended radio sources, or moderate flux sources missed entirely by radio source count surveys, cannot explain the bulk of the observed background, but may contribute as much as 10%. We consider both radio supernovae and radio quiet quasars as candidate sources for the background, and show that both fail to produce it at the observed level because of insufficient number of objects and total flux, although radio quiet quasars contribute at the level of at least a few percent. We conclude that the most important population for production of the background is likely ordinary starforming galaxies above redshift 1 characterized by an evolving radio far-infrared correlation, which increases toward the radio loud with redshift.

  16. Due diligence responsibilities of the professional geologist

    SciTech Connect

    Hobbs, G.W. )

    1991-03-01

    Whether in the role of independent consultant or company employee, a geologist has certain professional obligations in the evaluation of an oil and gas submittal from a third party. 'Due diligence' is the term used to describe the analysis of an investment opportunity. Due diligence involves a multidisciplinary examination of both the technical and business aspects of a submittal. In addition to the obvious geological considerations, prospect evaluations should include relevant details about the specific technical documentation reviewed, information sources, and how the data were verified. Full disclosure of ownership, technical risks, and negative aspects of the prospect should be included along with the positive elements. After the geological analysis is completed, the economic merits of the prospect should be analyzed, incorporating all lease burdens and terms of participation into the calculations. Estimated exploration, development, and operating costs, together with projected annual production, cash flow, and reserves must be examined as to their reasonableness. Finally, the due diligence review should include a thorough check on the reputation, financial condition, technical and managerial expertise, and prior track record of the operator. Bank, trade, legal, and prior partner references should be contacted. The successful professional geologist in today's competitive world must have multidisciplinary skills. A solid background in geology and geophysics, a basic understanding of the principles of petroleum engineering and economics, and the wits of a private eye are needed for good due diligence work.

  17. Gravitational wave background from rotating neutron stars

    NASA Astrophysics Data System (ADS)

    Rosado, Pablo A.

    2012-11-01

    The background of gravitational waves produced by the ensemble of rotating neutron stars (which includes pulsars, magnetars, and gravitars) is investigated. A formula for Ω(f) (a function that is commonly used to quantify the background, and is directly related to its energy density) is derived, without making the usual assumption that each radiating system evolves on a short time scale compared to the Hubble time; the time evolution of the systems since their formation until the present day is properly taken into account. Moreover, the formula allows one to distinguish the different parts of the background: the unresolvable (which forms a stochastic background or confusion noise, since the waveforms composing it cannot be either individually observed or subtracted out of the data of a detector) and the resolvable. Several estimations of the background are obtained, for different assumptions on the parameters that characterize neutron stars and their population. In particular, different initial spin period distributions lead to very different results. For one of the models, with slow initial spins, the detection of the background by present or planned detectors can be rejected. However, other models do predict the detection of the background, that would be unresolvable, by the future ground-based gravitational wave detector ET. A robust upper limit for the background of rotating neutron stars is obtained; it does not exceed the detection threshold of two cross-correlated Advanced LIGO interferometers. If gravitars exist and constitute more than a few percent of the neutron star population, then they produce an unresolvable background that could be detected by ET. Under the most reasonable assumptions on the parameters characterizing a neutron star, the background is too faint to be detected. Previous papers have suggested neutron star models in which large magnetic fields (like the ones that characterize magnetars) induce big deformations in the star, which

  18. Exploiting background knowledge in automated discovery

    SciTech Connect

    Aronis, J.M.; Buchanan, B.G.; Provost, F.J.

    1996-12-31

    Prior work in automated scientific discovery has been successful in finding patterns in data, given that a reasonably small set of mostly relevant features is specified. The work described in this paper places data in the context of large bodies of background knowledge. Specifically, data items are connected to multiple databases of background knowledge represented as inheritance networks. The system has made a practical impact on botanical toxicology research, which required linking examples of cases of plant exposures to databases of botanical, geographical, and climate background knowledge.

  19. Simulation results of Pulse Shape Discrimination (PSD) for background reduction in INTEGRAL Spectrometer (SPI) germanium detectors

    NASA Technical Reports Server (NTRS)

    Slassi-Sennou, S. A.; Boggs, S. E.; Feffer, P. T.; Lin, R. P.

    1997-01-01

    Pulse Shape Discrimination (PSD) for background reduction will be used in the INTErnational Gamma Ray Astrophysics Laboratory (INTEGRAL) imaging spectrometer (SPI) to improve the sensitivity from 200 keV to 2 MeV. The observation of significant astrophysical gamma ray lines in this energy range is expected, where the dominant component of the background is the beta(sup -) decay in the Ge detectors due to the activation of Ge nuclei by cosmic rays. The sensitivity of the SPI will be improved by rejecting beta(sup -) decay events while retaining photon events. The PSD technique will distinguish between single and multiple site events. Simulation results of PSD for INTEGRAL-type Ge detectors using a numerical model for pulse shape generation are presented. The model was shown to agree with the experimental results for a narrow inner bore closed end cylindrical detector. Using PSD, a sensitivity improvement factor of the order of 2.4 at 0.8 MeV is expected.

  20. Simulation results of Pulse Shape Discrimination (PSD) for background reduction in INTEGRAL Spectrometer (SPI) germanium detectors

    NASA Technical Reports Server (NTRS)

    Slassi-Sennou, S. A.; Boggs, S. E.; Feffer, P. T.; Lin, R. P.

    1997-01-01

    Pulse Shape Discrimination (PSD) for background reduction will be used in the INTErnational Gamma Ray Astrophysics Laboratory (INTEGRAL) imaging spectrometer (SPI) to improve the sensitivity from 200 keV to 2 MeV. The observation of significant astrophysical gamma ray lines in this energy range is expected, where the dominant component of the background is the beta(sup -) decay in the Ge detectors due to the activation of Ge nuclei by cosmic rays. The sensitivity of the SPI will be improved by rejecting beta(sup -) decay events while retaining photon events. The PSD technique will distinguish between single and multiple site events. Simulation results of PSD for INTEGRAL-type Ge detectors using a numerical model for pulse shape generation are presented. The model was shown to agree with the experimental results for a narrow inner bore closed end cylindrical detector. Using PSD, a sensitivity improvement factor of the order of 2.4 at 0.8 MeV is expected.