Impact of an inquiry unit on grade 4 students' science learning

NASA Astrophysics Data System (ADS)

Di Mauro, María Florencia; Furman, Melina

2016-09-01

This paper concerns the identification of teaching strategies that enhance the development of 4th grade students' experimental design skills at a public primary school in Argentina. Students' performance in the design of relevant experiments was evaluated before and after an eight-week intervention compared to a control group, as well as the persistence of this learning after eight months. The study involved a quasi-experimental longitudinal study with pre-test/post-test/delayed post-test measures, complemented with semi-structured interviews with randomly selected students. Our findings showed improvement in the experimental design skills as well as its sustainability among students working with the inquiry-based sequence. After the intervention, students were able to establish valid comparisons, propose pertinent designs and identify variables that should remain constant. Contrarily, students in the control group showed no improvement and continued to solve the posed problems based on prior beliefs. In summary, this paper shows evidence that implementing inquiry-based units involving problems set in cross-domain everyday situations that combine independent student work with teacher guidance significantly improves the development of scientific skills in real classroom contexts.

In silico simulations of experimental protocols for cardiac modeling.

PubMed

Carro, Jesus; Rodriguez, Jose Felix; Pueyo, Esther

2014-01-01

A mathematical model of the AP involves the sum of different transmembrane ionic currents and the balance of intracellular ionic concentrations. To each ionic current corresponds an equation involving several effects. There are a number of model parameters that must be identified using specific experimental protocols in which the effects are considered as independent. However, when the model complexity grows, the interaction between effects becomes increasingly important. Therefore, model parameters identified considering the different effects as independent might be misleading. In this work, a novel methodology consisting in performing in silico simulations of the experimental protocol and then comparing experimental and simulated outcomes is proposed for parameter model identification and validation. The potential of the methodology is demonstrated by validating voltage-dependent L-type calcium current (ICaL) inactivation in recently proposed human ventricular AP models with different formulations. Our results show large differences between ICaL inactivation as calculated from the model equation and ICaL inactivation from the in silico simulations due to the interaction between effects and/or to the experimental protocol. Our results suggest that, when proposing any new model formulation, consistency between such formulation and the corresponding experimental data that is aimed at being reproduced needs to be first verified considering all involved factors.

Nuclear spectroscopic studies. Progress report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bingham, C.R.; Guidry, M.W.; Riedinger, L.L.

1994-02-18

The Nuclear Physics group at UTK is involved in heavy-ion physics including both nuclear structure and reaction mechanisms. During the last year experimental work has been in 3 broad areas: structure of nuclei at high angular momentum, structure of nuclei far from stability, and ultra-relativistic heavy-ion physics. Results in these areas are described in this document under: properties of high-spin states, study of low-energy levels of nuclei far from stability, and high-energy heavy-ion physics (PHENIX, etc.). Another important component of the work is theoretical interpretation of experimental results (Joint Institute for Heavy Ion Research).

Investigation of the Thermomechanical Response of Shape Memory Alloy Hybrid Composite Beams

NASA Technical Reports Server (NTRS)

Davis, Brian A.

2005-01-01

Previous work at NASA Langley Research Center (LaRC) involved fabrication and testing of composite beams with embedded, pre-strained shape memory alloy (SMA) ribbons. That study also provided comparison of experimental results with numerical predictions from a research code making use of a new thermoelastic model for shape memory alloy hybrid composite (SMAHC) structures. The previous work showed qualitative validation of the numerical model. However, deficiencies in the experimental-numerical correlation were noted and hypotheses for the discrepancies were given for further investigation. The goal of this work is to refine the experimental measurement and numerical modeling approaches in order to better understand the discrepancies, improve the correlation between prediction and measurement, and provide rigorous quantitative validation of the numerical model. Thermal buckling, post-buckling, and random responses to thermal and inertial (base acceleration) loads are studied. Excellent agreement is achieved between the predicted and measured results, thereby quantitatively validating the numerical tool.

Equipment for Subpicosecond Extreme Ultraviolet Facility.

DTIC Science & Technology

1986-02-05

Excitation Induced by...................... 36 Coherent Motion of Outer-Shell Electrons" E. "A Theoretical Model of Inner-Shell...efficient production of x-rays are feasible. Our work involves a program of activities, involving both experimental -nd theoretical components, to...in addition to a theoretical effort con- itrating on the character of high order multiquantum coupling in the inten- I regime above 10 1 7 W cm2 . In

Oculomotor preparation as a rehearsal mechanism in spatial working memory.

PubMed

Pearson, David G; Ball, Keira; Smith, Daniel T

2014-09-01

There is little consensus regarding the specific processes responsible for encoding, maintenance, and retrieval of information in visuo-spatial working memory (VSWM). One influential theory is that VSWM may involve activation of the eye-movement (oculomotor) system. In this study we experimentally prevented healthy participants from planning or executing saccadic eye-movements during the encoding, maintenance, and retrieval stages of visual and spatial working memory tasks. Participants experienced a significant reduction in spatial memory span only when oculomotor preparation was prevented during encoding or maintenance. In contrast there was no reduction when oculomotor preparation was prevented only during retrieval. These results show that (a) involvement of the oculomotor system is necessary for optimal maintenance of directly-indicated locations in spatial working memory and (b) oculomotor preparation is not necessary during retrieval from spatial working memory. We propose that this study is the first to unambiguously demonstrate that the oculomotor system contributes to the maintenance of spatial locations in working memory independently from the involvement of covert attention. Copyright © 2014 The Authors. Published by Elsevier B.V. All rights reserved.

Filtrates & Residues: Experimental Work with Tin (II) Chloride in a High School.

ERIC Educational Resources Information Center

Sanchez, Manuela Martin

1988-01-01

Presents a high school chemistry lab experiment using tin (II) chloride to explore the concepts of hydrolysis, Le Chatelier's principle, and electrolysis. Presents methodology and the chemistry involved. Offers questions for the students. (MVL)

Experimental determination of useful resistance value during pasta dough kneading

NASA Astrophysics Data System (ADS)

Podgornyj, Yu I.; Martynova, T. G.; Skeeba, V. Yu; Kosilov, A. S.; Chernysheva, A. A.; Skeeba, P. Yu

2017-10-01

There is a large quantity of materials produced in the form of dry powder or low humidity granulated masses in the modern market, and there is a need to develop new manufacturing machinery and to renew the existing facilities involved in the production of various loose mixtures. One of the machinery upgrading tasks is enhancing its performance. In view of the fact that experimental research is not feasible in full-scale samples, an experimental installation was to be constructed. The article contains its kinematic scheme and the 3D model. The angle of the kneading blade location, the volume of the loose mixture, rotating frequency and the number of the work member double passes were chosen as variables to carry out the experiment. The technique of the experiment, which includes two stages for the rotary and reciprocating movement of the work member, was proposed. The results of the experimental data processing yield the correlations between the load characteristics of the mixer work member and the angle of the blade, the volume of the mixture and the work member rotating frequency, allowing for the recalculation of loads for this type machines.

Formative Peer Assessment in Primary School: The Effects of Involving Pupils in Setting Assessment Criteria on Their Appraisal and Feedback Style

ERIC Educational Resources Information Center

Leenknecht, Martijn J. M.; Prins, Frans J.

2018-01-01

This experimental study is aimed at examining the effect of involving pupils in primary education in setting assessment criteria and standards on their appraisal of a peer's work and their peer feedback style. It is expected that our intervention will lead to (1) a criteria-referenced appraisal and (2) more final vocabulary, which is associated…

Coherent Extreme Ultraviolet Generation and Surface Studies Using Ultraviolet Excimer Lasers.

DTIC Science & Technology

1986-02-10

of Outer-Shell Electrons" 7. "A Theoretical Model of Inner-Shell ......................... 30 A Excitation by Outer-Snell Electrons" E. "Anomalous...rays are feasible. Our work involves a program of activities, involving both experimental and theoretical components, to explore the physical... theoretical effort con- centrating on the character of high order multiquantum coupling in the inten- sity regime above 1017 WcM2 . In addition

Compendium of Authenticated Systems and Logistics Terms, Definitions and Acronyms

DTIC Science & Technology

1981-04-01

assigned for storage operations, within OTHER NON WAREHOUSE SPACE a structure designed for other than storage Space being used for storage within any...opposed to Any work done in order to correct rejected work. administrative), design (engineering design and (AFLCM1 74-2) drafting), experimental test...study. (principal or designated representative) authorized practices, methodology , or procedures involved in to request, receive, store, and account

A Research Experience for Undergraduates on Sustainable Land and Water Resources

NASA Astrophysics Data System (ADS)

Dalbotten, D. M.; Berthelote, A. R.; Myrbo, A.; Ito, E.; Howes, T.

2011-12-01

A new research experience for undergraduates is being piloted which supports student involvement in management of land and water resources with sustainability as the major focus. Working on two Native American reservations (Fond du Lac Band of Lake Superior Chippewa, and Confederated Salish and Kootenai Tribes of Flathead Reservation) and in conjunction with local tribal colleges, we particularly focus on management of tribal land and water resources. In this way we work to both increase the involvement of Native American students in the geosciences and support ethical partnerships for research on Native lands. Students also have the opportunity to work experimentally at the St. Anthony Falls Laboratory in conjunction with the National Center for Earth-surface Dynamics.

Statistical modelling of networked human-automation performance using working memory capacity.

PubMed

Ahmed, Nisar; de Visser, Ewart; Shaw, Tyler; Mohamed-Ameen, Amira; Campbell, Mark; Parasuraman, Raja

2014-01-01

This study examines the challenging problem of modelling the interaction between individual attentional limitations and decision-making performance in networked human-automation system tasks. Analysis of real experimental data from a task involving networked supervision of multiple unmanned aerial vehicles by human participants shows that both task load and network message quality affect performance, but that these effects are modulated by individual differences in working memory (WM) capacity. These insights were used to assess three statistical approaches for modelling and making predictions with real experimental networked supervisory performance data: classical linear regression, non-parametric Gaussian processes and probabilistic Bayesian networks. It is shown that each of these approaches can help designers of networked human-automated systems cope with various uncertainties in order to accommodate future users by linking expected operating conditions and performance from real experimental data to observable cognitive traits like WM capacity. Practitioner Summary: Working memory (WM) capacity helps account for inter-individual variability in operator performance in networked unmanned aerial vehicle supervisory tasks. This is useful for reliable performance prediction near experimental conditions via linear models; robust statistical prediction beyond experimental conditions via Gaussian process models and probabilistic inference about unknown task conditions/WM capacities via Bayesian network models.

Architectures for Quantum Simulation Showing a Quantum Speedup

NASA Astrophysics Data System (ADS)

Bermejo-Vega, Juan; Hangleiter, Dominik; Schwarz, Martin; Raussendorf, Robert; Eisert, Jens

2018-04-01

One of the main aims in the field of quantum simulation is to achieve a quantum speedup, often referred to as "quantum computational supremacy," referring to the experimental realization of a quantum device that computationally outperforms classical computers. In this work, we show that one can devise versatile and feasible schemes of two-dimensional, dynamical, quantum simulators showing such a quantum speedup, building on intermediate problems involving nonadaptive, measurement-based, quantum computation. In each of the schemes, an initial product state is prepared, potentially involving an element of randomness as in disordered models, followed by a short-time evolution under a basic translationally invariant Hamiltonian with simple nearest-neighbor interactions and a mere sampling measurement in a fixed basis. The correctness of the final-state preparation in each scheme is fully efficiently certifiable. We discuss experimental necessities and possible physical architectures, inspired by platforms of cold atoms in optical lattices and a number of others, as well as specific assumptions that enter the complexity-theoretic arguments. This work shows that benchmark settings exhibiting a quantum speedup may require little control, in contrast to universal quantum computing. Thus, our proposal puts a convincing experimental demonstration of a quantum speedup within reach in the near term.

Limbic control of aggression in the cat.

PubMed

Adamec, R E; Stark-Adamec, C I

1983-01-01

Over a decade of work by Flynn and colleagues has delineated a network of limbic circuits which function to modulate the expression of predatory aggression and defence in the cat, and aspects of this work are reviewed. In particular, Flynn's work revealed a circuit involving the basomedial amygdala which functions to suppress attack, and at the same time facilitates defence. A second circuit, involving the ventral hippocampus, is involved in attack facilitation. Studies relating stable differences in excitability in these two circuits to developmentally determined behavioural dispositions toward aggression or defence are summarized. Finally, the impact of experimentally induced limbic seizures on interictally maintained expression of aggression and defence behaviourally, and on limbic excitability are reviewed. Taken together, the data indicate that the behavioural balance of attack and defence is under the tonic control of opponent limbic circuits, which are themselves biased in a measureable manner. Developmental studies indicate that adult defensiveness is determined early in life, so early as to suggest some pre-programmed neuro-developmental process. Experimentally induced seizures alter behaviour lastingly, producing an increase in defensive disposition. At the same time there is an equally lasting potentiation of interictal transmission of neural activity from the amygdala to the hypothalamus. Moreover, seizures may reduce interictal transmission of activity through the ventral hippocampus by potentiating recurrent inhibition. These effects of seizures are of interest since seizures reproduce naturally occurring differences in limbic excitability seen in naturally defensive cats.

An ion accelerator for undergraduate research and teaching

NASA Astrophysics Data System (ADS)

Monce, Michael

1997-04-01

We have recently upgraded our 400kV, single beam line ion accelerator to a 1MV, multiple beam line machine. This upgrade has greatly expanded the opportunities for student involvement in the laboratory. We will describe four areas of work in which students now participate. The first is the continuing research being conducted in excitations produced in ion-molecule collisions, which recently involved the use of digital imaging. The second area of research now opened up by the new accelerator involves PIXE. We are currently beginning a cross disciplinary study of archaeological specimens using PIXE and involving students from both anthropology and physics. Finally, two beam lines from the accelerator will be used for basic work in nuclear physics: Rutherford scattering and nuclear resonances. These two nuclear physics experiments will be integrated into our sophomore-junior level, year-long course in experimental physics.

DoE Plasma Center for Momentum Transport and Flow Self-Organization in Plasmas: Non-linear Emergent Structure Formation in magnetized Plasmas and Rotating Magnetofluids

DOE Office of Scientific and Technical Information (OSTI.GOV)

Forest, Cary B.

This report covers the UW-Madison activities that took place within a larger DoE Center Administered and directed by Professor George Tynan at the University of California, San Diego. The work at Wisconsin will also be covered in the final reporting for the entire center, which will be submitted by UCSD. There were two main activities, one experimental and one that was theoretical in nature, as part of the Center activities at the University of Wisconsin, Madison. First, the Center supported an experimentally focused postdoc (Chris Cooper) to carry out fundamental studies of momentum transport in rotating and weakly magnetized plasma.more » His experimental work was done on the Plasma Couette Experiment, a cylindrical plasma confinement device, with a plasma flow created through electromagnetically stirring plasma at the plasma edge facilitated by arrays of permanent magnets. Cooper's work involved developing optical techniques to measure the ion temperature and plasma flow through Doppler-shifted line radiation from the plasma argon ions. This included passive emission measurements and development of a novel ring summing Fabry-Perot spectroscopy system, and the active system involved using a diode laser to induce fluorescence. On the theoretical side, CMTFO supported a postdoc (Johannes Pueschel) to carry out a gyrokinetic extension of residual zonal flow theory to the case with magnetic fluctuations, showing that magnetic stochasticity disrupts zonal flows. The work included a successful comparison with gyrokinetic simulations. This work and its connection to the broader CMTFO will be covered more thoroughly in the final CMTFO report from Professor Tynan.« less

On the Learning of Mathematics Through Conversation.

ERIC Educational Resources Information Center

Haroutunian-Gordan, Sophie; Tartakoff, David S.

1996-01-01

Describes an experimental mathematics course involving an interpretive discussion approach in which students and instructors work together to develop questions about the meaning of mathematical, philosophical, and musical texts. Appendix contains a cluster of questions for Euclid's proof of the infinity of prime numbers. (MKR)

Old Wine into New Bottles.

ERIC Educational Resources Information Center

Crandall, G. Douglas

1997-01-01

Discusses how traditional lab exercises can be converted into investigative exercises. Describes an exercise on seed germination that has students design their own experiments based on their initial results. Involves students in the scientific process and allows them to experience the joys and disappointments of experimental work. (JRH)

Evaluation of tocopherol recovery through simulation of molecular distillation process.

PubMed

Moraes, E B; Batistella, C B; Alvarez, M E Torres; Filho, Rubens Maciel; Maciel, M R Wolf

2004-01-01

DISMOL simulator was used to determine the best possible operating conditions to guide, in future studies, experimental works. This simulator needs several physical-chemical properties and often it is very difficult to determine them because of the complexity of the involved components. Their determinations must be made through correlations and/or predictions, in order to characterize the system and calculate it. The first try is to have simulation results of a system that later can be validated with experimental data. To implement, in the simulator, the necessary parameters of complex systems is a difficult task. In this work, we aimed to determe these properties in order to evaluate the tocopherol (vitamin E) recovery using a DISMOL simulator. The raw material used was the crude deodorizer distillate of soya oil. With this procedure, it is possible to determine the best operating conditions for experimental works and to evaluate the process in the separation of new systems, analyzing the profiles obtained from these simulations for the falling film molecular distillator.

Two-Phase Flow in Packed Columns and Generation of Bubbly Suspensions for Chemical Processing in Space

NASA Technical Reports Server (NTRS)

Motil, Brian J.; Green, R. D.; Nahra, H. K.; Sridhar, K. R.

2000-01-01

For long-duration space missions, the life support and In-Situ Resource Utilization (ISRU) systems necessary to lower the mass and volume of consumables carried from Earth will require more sophisticated chemical processing technologies involving gas-liquid two-phase flows. This paper discusses some preliminary two-phase flow work in packed columns and generation of bubbly suspensions, two types of flow systems that can exist in a number of chemical processing devices. The experimental hardware for a co-current flow, packed column operated in two ground-based low gravity facilities (two-second drop tower and KC- 135 low-gravity aircraft) is described. The preliminary results of this experimental work are discussed. The flow regimes observed and the conditions under which these flow regimes occur are compared with the available co-current packed column experimental work performed in normal gravity. For bubbly suspensions, the experimental hardware for generation of uniformly sized bubbles in Couette flow in microgravity conditions is described. Experimental work was performed on a number of bubbler designs, and the capillary bubble tube was found to produce the most consistent size bubbles. Low air flow rates and low Couette flow produce consistent 2-3 mm bubbles, the size of interest for the "Behavior of Rapidly Sheared Bubbly Suspension" flight experiment. Finally the mass transfer implications of these two-phase flows is qualitatively discussed.

Part weight verification between simulation and experiment of plastic part in injection moulding process

NASA Astrophysics Data System (ADS)

Amran, M. A. M.; Idayu, N.; Faizal, K. M.; Sanusi, M.; Izamshah, R.; Shahir, M.

2016-11-01

In this study, the main objective is to determine the percentage difference of part weight between experimental and simulation work. The effect of process parameters on weight of plastic part is also investigated. The process parameters involved were mould temperature, melt temperature, injection time and cooling time. Autodesk Simulation Moldflow software was used to run the simulation of the plastic part. Taguchi method was selected as Design of Experiment to conduct the experiment. Then, the simulation result was validated with the experimental result. It was found that the minimum and maximum percentage of differential of part weight between simulation and experimental work are 0.35 % and 1.43 % respectively. In addition, the most significant parameter that affected part weight is the mould temperature, followed by melt temperature, injection time and cooling time.

Do cooperative learning and family involvement improve variables linked to academic performance?

PubMed

Santos Rego, Miguel A; Ferraces Otero, María J; Godas Otero, Agustín; Lorenzo Moledo, María M

2018-05-01

One of the most serious problems in the Spanish education system is the high percentage of school failure in Compulsory Secondary Education. The aim of this study is to analyze the influence of a socio-educational program based on cooperative learning and family involvement on a series of variables related to academic performance, paying particular attention to the differences between retained and non-retained students. A two-group quasi-experimental design incorporating pre-testing and post-testing was used. The study involved 146 students in the experimental group and 123 in the control group, 8 teachers, and 89 parents or other family members. The program was observed to have a positive effect on self-image, study habits, satisfaction with the subject, maternal support and control, and opinions about the school. In addition, the results for non-retained students are better. Cooperative work and family involvement in education affect the variables which research links to improving school performance.

Assessment of an intervention to train teaching hospital care providers in quality management

PubMed Central

Francois, P; Vinck, D; Labarere, J; Reverdy, T; Peyrin, J

2005-01-01

Background: Successful implementation of continuous quality improvement (CQI) programs in hospitals remains rare in all countries, making it necessary to experiment with implementation methods while considering the cultural factors of resistance to change. Objective: To assess the impact of an educational intervention on involvement of clinical department staff in the quality process. Setting: Twelve voluntary clinical departments (six experimental and six controls) in a French 2000-bed university hospital comprising 40 clinical departments. Intervention: Three day training seminar to a group of 12–20 staff members from each department. Design: Quasi-experimental post-test only design study with control group conducted 12 months after the intervention with a questionnaire completed in a face-to-face interview. Subjects: 98 trained staff and 100 untrained staff from the six experimental departments and 100 staff from the six control departments. Principal measurements: Declared knowledge of the CQI methods and participation in quality management activities. Results: 286 people (96%) were involved in the study. More of the trained staff knew the CQI methods (62.4%) than staff in the control departments (16.5%) (adjusted odds ratio (ORa) = 10.6 (95% CI 4.97 to 22.62)). More trained staff also participated in quality improvement work groups than control department staff (76.3% v 14.0%; ORa = 27.4 (95% CI 11.6 to 64.4)). In the experimental departments the untrained staff's knowledge of CQI methods and their participation in work groups did not differ from that of control department staff. Conclusions: A continuing education intervention can involve care providers in CQI. Dissemination of knowledge from trained personnel to other staff members remains limited. PMID:16076785

Stability Limits and Dynamics of Nonaxisymmetric Liquid Bridges

NASA Technical Reports Server (NTRS)

Alexander, J. Iwan D.

1998-01-01

Theoretical and experimental investigation of the stability of nonaxisymmetric and nonaxisymmetric bridges contained between equal and unequal radii disks as a function of Bond and Weber number with emphasis on the transition from unstable axisymmetric to stable nonaxisymmetric shapes. Numerical analysis of the stability of nonaxisymmetric bridges for various orientations of the gravity vector for equal and unequal disks. Experimental and theoretical investigation of large (nonaxisymmetric) oscillations and breaking of liquid bridges. This project involves both experimental and theoretical work. Static and dynamic experiments are conducted in a Plateau tank which makes a range of static Bond numbers accessible.

Reducing physical size limits for low-frequency horn loudspeaker systems

NASA Astrophysics Data System (ADS)

Honeycutt, Richard Allison

From 1881 until the present day, many excellent scholars have studied acoustic horns. This dissertation begins by discussing over eighty results of such study. Next, the methods of modeling horn behavior are examined with an emphasis on the prediction of throat impedance. Because of the time constraints in a product-design environment, in which the results of this study may be used, boundary-element and cascaded-section types of analysis were not considered due to their time intensiveness. Of the methods studied, an analytical process based upon Olson's adaptation of Webster's analysis is selected as the most accurate of the rapid methods, although other good methods exist. Reasons and extent of inaccuracy are discussed. The concept of interleaved horn loading is introduced: it involves using two horns of different parameters, fed by a single driver, with a view toward interleaving and thus smoothing the impedance peaks of the separate horns to produce a smoother response. The validity of the technique is demonstrated both theoretically and practically. Then the reactance annulling technique is explained and tested experimentally. It is found to work well, but the exact parameter values involved are not found to be critical. Finally, the considerations involved in building a practical working system are discussed, and a preliminary working model reviewed. Future work could be directed toward finding the optimum parameter values for the two "parallel horns" whose impedances are to be interleaved, as well as the system parameters that determine these optimum values. Also, further experimental investigation or ported loading of the back air chamber would be useful.

NASA Dryden Flight Research Center

NASA Technical Reports Server (NTRS)

Navarro, Robert

2009-01-01

This DVD has several short videos showing some of the work that Dryden is involved in with experimental aircraft. These are: shots showing the Active AeroElastic Wing (AAW) loads calibration tests, AAW roll maneuvers, AAW flight control surface inputs, Helios flight, and takeoff, and Pathfinder takeoff, flight and landing.

48 CFR 27.406-2 - Additional data requirements.

Code of Federal Regulations, 2010 CFR

2010-10-01

... solicitations and contracts involving experimental, developmental, research or demonstration work (other than basic or applied research to be performed under a contract solely by a university or college when the..., research, or demonstration contracts, it may not be feasible to ascertain all the data requirements at...

Changes in mode of travel to work: a natural experimental study of new transport infrastructure.

PubMed

Heinen, Eva; Panter, Jenna; Mackett, Roger; Ogilvie, David

2015-06-20

New transport infrastructure may promote a shift towards active travel, thereby improving population health. The purpose of this study was to determine the effect of a major transport infrastructure project on commuters' mode of travel, trip frequency and distance travelled to work. Quasi-experimental analysis nested within a cohort study of 470 adults working in Cambridge, UK. The intervention consisted of the opening of a guided busway with a path for walking and cycling in 2011. Exposure to the intervention was defined as the negative of the square root of the shortest distance from home to busway. The outcome measures were changes in commute mode share and number of commute trips - both based on a seven-day travel-to-work record collected before (2009) and after (2012) the intervention - and change in objective commute distance. The mode share outcomes were changes in the proportions of trips (i) involving any active travel, (ii) involving any public transport, and (iii) made entirely by car. Separate multinomial regression models were estimated adjusting for commute and sociodemographic characteristics, residential settlement size and life events. Proximity to the busway predicted an increased likelihood of a large (>30 %) increase in the share of commute trips involving any active travel (relative risk ratio [RRR] 1.80, 95 % CI 1.27, 2.55) and a large decrease in the share of trips made entirely by car (RRR 2.09, 95 % CI 1.35, 3.21), as well as a lower likelihood of a small (<30 %) reduction in the share of trips involving any active travel (RRR 0.47, 95 % CI 0.28, 0.81). It was not associated with changes in the share of commute trips involving any public transport, the number of commute trips, or commute distance. The new infrastructure promoted an increase in the share of commuting trips involving active travel and a decrease in the share made entirely by car. Further analysis will show the extent to which the changes in commute mode share were translated into an increase in time spent in active commuting and consequent health gain.

Bioinformatic prediction of leader genes in human periodontitis.

PubMed

Covani, Ugo; Marconcini, Simone; Giacomelli, Luca; Sivozhelevov, Victor; Barone, Antonio; Nicolini, Claudio

2008-10-01

Genes involved in different biologic processes form complex interaction networks. However, only a few have a high number of interactions with the other genes in the network. In previous bioinformatics and experimental studies concerning the T lymphocyte cell cycle, these genes were identified and termed "leader genes." In this work, genes involved in human periodontitis were tentatively identified and ranked according to their number of interactions to obtain a preliminary, broader view of molecular mechanisms of periodontitis and plan targeted experimentation. Genes were identified with interrelated queries of several databases. The interactions among these genes were mapped and given a significance score. The weighted number of links (weighted sum of scores for every interaction in which the given gene is involved) was calculated for each gene. Genes were clustered according to this parameter. The genes in the highest cluster were termed leader genes. Sixty-one genes involved or potentially involved in periodontitis were identified. Only five were identified as leader genes, whereas 12 others were ranked in an immediately lower cluster. For 10 of 17 genes there is evidence of involvement in periodontitis; seven new genes that are potentially involved in this disease were identified. The involvement in periodontitis has been completely established for only two leader genes. We applied a validated bioinformatics algorithm to increase our knowledge of molecular mechanisms of periodontitis. Even with the limitations of this ab initio analysis, this theoretical study can suggest ad hoc experimentation targeted on significant genes and, therefore, simpler than mass-scale molecular genomics. Moreover, the identification of leader genes might suggest new potential risk factors and therapeutic targets.

ERP Modulation during Observation of Abstract Paintings by Franz Kline

PubMed Central

Sbriscia-Fioretti, Beatrice; Berchio, Cristina; Freedberg, David; Gallese, Vittorio; Umiltà, Maria Alessandra

2013-01-01

The aim of this study was to test the involvement of sensorimotor cortical circuits during the beholding of the static consequences of hand gestures devoid of any meaning.In order to verify this hypothesis we performed an EEG experiment presenting to participants images of abstract works of art with marked traces of brushstrokes. The EEG data were analyzed by using Event Related Potentials (ERPs). We aimed to demonstrate a direct involvement of sensorimotor cortical circuits during the beholding of these selected works of abstract art. The stimuli consisted of three different abstract black and white paintings by Franz Kline. Results verified our experimental hypothesis showing the activation of premotor and motor cortical areas during stimuli observation. In addition, abstract works of art observation elicited the activation of reward-related orbitofrontal areas, and cognitive categorization-related prefrontal areas. The cortical sensorimotor activation is a fundamental neurophysiological demonstration of the direct involvement of the cortical motor system in perception of static meaningless images belonging to abstract art. These results support the role of embodied simulation of artist’s gestures in the perception of works of art. PMID:24130693

Optimal Experiment Design for Thermal Characterization of Functionally Graded Materials

NASA Technical Reports Server (NTRS)

Cole, Kevin D.

2003-01-01

The purpose of the project was to investigate methods to accurately verify that designed , materials meet thermal specifications. The project involved heat transfer calculations and optimization studies, and no laboratory experiments were performed. One part of the research involved study of materials in which conduction heat transfer predominates. Results include techniques to choose among several experimental designs, and protocols for determining the optimum experimental conditions for determination of thermal properties. Metal foam materials were also studied in which both conduction and radiation heat transfer are present. Results of this work include procedures to optimize the design of experiments to accurately measure both conductive and radiative thermal properties. Detailed results in the form of three journal papers have been appended to this report.

Combustion process science and technology

NASA Technical Reports Server (NTRS)

Hale, Robert R.

1989-01-01

An important and substantial area of technical work in which noncontact temperature measurement (NCTM) is desired is that involving combustion process research. In the planning for this workshop, it was hoped that W. Serignano would provide a briefing regarding the experimental requirements for thermal measurements to support such research. The particular features of thermal measurement requirements included those describing the timeline for combustion experiments, the requirements for thermal control and diagnostics of temperature and other related thermal measurements and the criticality to the involved science to parametric features of measurement capability including precision, repeatability, stability, and resolution. In addition, it was hoped that definitions could be provided which characterize the needs for concurrent imaging as it relates to science observations during the conduct of experimentation.

Scalar-tensor Theories of Gravity: Some personal history

NASA Astrophysics Data System (ADS)

Brans, Carl H.

2008-12-01

From a perspective of some 50 years or more, this paper reviews my recall of the early days of scalar-tensor alternatives to standard Einstein general relativistic theory of gravity. Of course, the story begins long before my involvement, going back to the proposals of Nordström in 1914, and that of Kaluza, Klein, et al., a few years later, sol include reviews of these seminal ideas and those that followed in the 1920's through the 1940's. This early work concerned the search for a Unified Field Theory, unifying gravity and Electromagnetism, using five dimensional manifolds. This formalism included not only the electromagnetic spacetime vector potential within the five-metric, but also a spacetime scalar as the five-five metric component. Although this was at first regarded more as a nuisance, to be set to a constant, it turned out later that Fierz, Jordan, Einstein and Bergmann noticed that this scalar could be a field, possibly related to the Newtonian gravitational constant. Relatively little theoretical and experimental attention was given to these ideas until after the second world war when Bob Dicke, motivated by the ideas of Mach, Dirac, and others, suggested that this additional scalar, coupled only to the metric and matter, could provide a reasonable and viable alternative to standard Einstein theory. This is the point of my direct involvement with these topics. However, it was Dicke's prominence and expertise in experimental work, together with the blossoming of NASA's experimental tools, that caused the explosion of interest, experimental and theoretical, in this possible alternative to standard Einstein theory. This interest has waxed and waned over the last 50 years, and we summarize some of this work.

A Vocational Approach to Written Communications. Final Report.

ERIC Educational Resources Information Center

Hutkin, Ronald M., Comp.

Students' cognitive and affective development in achieving written communication objectives in the context of the world of work were compared with the same objectives placed in a liberal arts context. The research project involved four groups of students at Platte Technical Community College. Two experimental groups completed the cognitive…

Prospects: the tomato genome as a cornerstone for gene discovery

USDA-ARS?s Scientific Manuscript database

Those involved in the international tomato genome sequencing effort contributed to not only the development of an important genome sequence relevant to a major economic and nutritional crop, but also to the tomato experimental system as a model for plant biology. Without question, prior seminal work...

75 FR 24966 - Endangered and Threatened Wildlife and Plants; Permit Applications

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-06

...: TE010887A. Applicant: U.S. Geological Survey, Great Lakes Science Center, Porter, Indiana. The applicant... involve capture of adult butterflies for captive rearing, experimental treatments on captive-reared larvae... conducting survey and assessment work. Activities are for the enhancement of survival of the species in the...

A Fresh Look at the Crystal Violet Lab with Handheld Camera Colorimetry

ERIC Educational Resources Information Center

Knutson, Theodore R.; Knutson, Cassandra M.; Mozzetti, Abbie R.; Campos, Antonio R.; Haynes, Christy L.; Penn, R. Lee

2015-01-01

Chemical kinetic experiments to determine rate laws are common in high school and college chemistry courses. For reactions involving a color change, rate laws can be determined experimentally using spectrophotometric or colorimetric equipment though this equipment can be cost prohibitive. Previous work demonstrated that inexpensive handheld camera…

Variable conductance heat pipe technology

NASA Technical Reports Server (NTRS)

Marcus, B. D.; Edwards, D. K.; Anderson, W. T.

1973-01-01

Research and development programs in variable conductance heat pipe technology were conducted. The treatment has been comprehensive, involving theoretical and/or experimental studies in hydrostatics, hydrodynamics, heat transfer into and out of the pipe, fluid selection, and materials compatibility, in addition to the principal subject of variable conductance control techniques. Efforts were not limited to analytical work and laboratory experimentation, but extended to the development, fabrication and test of spacecraft hardware, culminating in the successful flight of the Ames Heat Pipe Experiment on the OAO-C spacecraft.

Review of subcooled flow boiling critical heat flux (CHF) and its application to fusion energy system components part II: microconvective, experimental and correlational aspects

DOE Office of Scientific and Technical Information (OSTI.GOV)

Boyd, R.D.

This paper reviews the present understanding of critical heat flux (CHF) in subcooled flow boiling and outlines research directions which will permit the accommodation of higher heat fluxes. This survey, which covers the last 30 years, is concerned only with CHF in the subcooled flow boiling regime and unless otherwise noted, all references to CHF will be confined to that regime. This paper (Part II) summarizes microconvective, instability, experimental and correlational aspects of CHF. Section II covers microconvection and instabilities, section III covers representative experimental work, and section IV summarizes and compares selected CHF correlations. Section V documents previous flowmore » visualization work and section VI contains conclusions and recommendations concerning problem areas and suggested research directions essential to the HHFCDP, which involves extending steady state and transient CHF towards 30 kW/cm/sup 2/.« less

Evaluating the use of electronegativity in band alignment models through the experimental slope parameter of lanthanum aluminate heterostructures

DOE Office of Scientific and Technical Information (OSTI.GOV)

Liu, Z. Q.; Chim, W. K.; Chiam, S. Y

2011-11-01

In this work, photoelectron spectroscopy is used to characterize the band alignment of lanthanum aluminate heterostructures which possess a wide range of potential applications. It is found that our experimental slope parameter agrees with theory using the metal-induced gap states model while the interface induced gap states (IFIGS) model yields unsatisfactory results. We show that this discrepancy can be attributed to the correlation between the dielectric work function and the electronegativity in the IFIGS model. It is found that the original trend, as established largely by metals, may not be accurate for larger band gap materials. By using a newmore » correlation, our experimental data shows good agreement of the slope parameter using the IFIGS model. This correlation, therefore, plays a crucial role in heterostructures involving wider bandgap materials for accurate band alignment prediction using the IFIGS model.« less

Advanced Reactors-Intermediate Heat Exchanger (IHX) Coupling: Theoretical Modeling and Experimental Validation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Utgikar, Vivek; Sun, Xiaodong; Christensen, Richard

2016-12-29

The overall goal of the research project was to model the behavior of the advanced reactorintermediate heat exchange system and to develop advanced control techniques for off-normal conditions. The specific objectives defined for the project were: 1. To develop the steady-state thermal hydraulic design of the intermediate heat exchanger (IHX); 2. To develop mathematical models to describe the advanced nuclear reactor-IHX-chemical process/power generation coupling during normal and off-normal operations, and to simulate models using multiphysics software; 3. To develop control strategies using genetic algorithm or neural network techniques and couple these techniques with the multiphysics software; 4. To validate themore » models experimentally The project objectives were accomplished by defining and executing four different tasks corresponding to these specific objectives. The first task involved selection of IHX candidates and developing steady state designs for those. The second task involved modeling of the transient and offnormal operation of the reactor-IHX system. The subsequent task dealt with the development of control strategies and involved algorithm development and simulation. The last task involved experimental validation of the thermal hydraulic performances of the two prototype heat exchangers designed and fabricated for the project at steady state and transient conditions to simulate the coupling of the reactor- IHX-process plant system. The experimental work utilized the two test facilities at The Ohio State University (OSU) including one existing High-Temperature Helium Test Facility (HTHF) and the newly developed high-temperature molten salt facility.« less

Experimental test of nonlocal realistic theories without the rotational symmetry assumption.

PubMed

Paterek, Tomasz; Fedrizzi, Alessandro; Gröblacher, Simon; Jennewein, Thomas; Zukowski, Marek; Aspelmeyer, Markus; Zeilinger, Anton

2007-11-23

We analyze the class of nonlocal realistic theories that was originally considered by Leggett [Found. Phys. 33, 1469 (2003)10.1023/A:1026096313729] and tested by us in a recent experiment [Nature (London) 446, 871 (2007)10.1038/nature05677]. We derive an incompatibility theorem that works for finite numbers of polarizer settings and that does not require the previously assumed rotational symmetry of the two-particle correlation functions. The experimentally measured case involves seven different measurement settings. Using polarization-entangled photon pairs, we exclude this broader class of nonlocal realistic models by experimentally violating a new Leggett-type inequality by 80 standard deviations.

Control of flexible beams using a free-free active truss

NASA Technical Reports Server (NTRS)

Clark, W. W.; Kimiavi, B.; Robertshaw, H. H.

1989-01-01

An analytical and experimental study involving controlling flexible beams using a free-free active truss is presented. This work extends previous work in controlling flexible continua with active trusses which were configured with fixed-free boundary conditions. The following describes the Lagrangian approach used to derive the equations of motion for the active truss and the beams attached to it. A partial-state feedback control law is derived for this system based on a full-state feedback Linear Quadratic Regulator method. The analytical model is examined via numerical simulations and the results are compared to a similar experimental apparatus described herein. The results show that control of a flexible continua is possible with a free-free active truss.

MAP Markers: Research and Evaluation of the Mutual Agreement Program. Resource Document No. 5.

ERIC Educational Resources Information Center

Robison, James O.

This report is an evaluation, using randomized experimental/control design, of a program involving negotiated contractual agreements (MAP) between prisoners and parole boards for specific parole dates contingent on performance in work, training and treatment activities. Contracts were generally for less than six months. Both feasibility and…

Evaluation Designs for Practitioners. TM Report No. 35.

ERIC Educational Resources Information Center

Eash, Maurice J.; And Others

Practitioners are not afforded the luxury of ideal laboratory conditions. The natural settings of the classroom, the school, or the school system place constraints on the type of data obtainable; hence, educators must work with less than an ideal experimental design. Four evaluation designs used in natural settings are described. Each involves an…

Joint surface modeling with thin-plate splines.

PubMed

Boyd, S K; Ronsky, J L; Lichti, D D; Salkauskas, K; Chapman, M A; Salkauskas, D

1999-10-01

Mathematical joint surface models based on experimentally determined data points can be used to investigate joint characteristics such as curvature, congruency, cartilage thickness, joint contact areas, as well as to provide geometric information well suited for finite element analysis. Commonly, surface modeling methods are based on B-splines, which involve tensor products. These methods have had success; however, they are limited due to the complex organizational aspect of working with surface patches, and modeling unordered, scattered experimental data points. An alternative method for mathematical joint surface modeling is presented based on the thin-plate spline (TPS). It has the advantage that it does not involve surface patches, and can model scattered data points without experimental data preparation. An analytical surface was developed and modeled with the TPS to quantify its interpolating and smoothing characteristics. Some limitations of the TPS include discontinuity of curvature at exactly the experimental surface data points, and numerical problems dealing with data sets in excess of 2000 points. However, suggestions for overcoming these limitations are presented. Testing the TPS with real experimental data, the patellofemoral joint of a cat was measured with multistation digital photogrammetry and modeled using the TPS to determine cartilage thicknesses and surface curvature. The cartilage thickness distribution ranged between 100 to 550 microns on the patella, and 100 to 300 microns on the femur. It was found that the TPS was an effective tool for modeling joint surfaces because no preparation of the experimental data points was necessary, and the resulting unique function representing the entire surface does not involve surface patches. A detailed algorithm is presented for implementation of the TPS.

Studies of nonlinear femtosecond pulse propagation in bulk materials

NASA Astrophysics Data System (ADS)

Eaton, Hilary Kaye

2000-10-01

Femtosecond pulse lasers are finding widespread application in a variety of fields including medical research, optical switching and communications, plasma formation, high harmonic generation, and wavepacket formation and control. As the number of applications for femtosecond pulses increases, so does the need to fully understand the linear and nonlinear processes involved in propagating these pulses through materials under various conditions. Recent advances in pulse measurement techniques, such as frequency-resolved optical gating (FROG), allow measurement of the full electric field of the pulse and have made detailed investigations of short- pulse propagation effects feasible. In this thesis, I present detailed experimental studies of my work involving nonlinear propagation of femtosecond pulses in bulk media. Studies of plane-wave propagation in fused silica extend the SHG form of FROG from a simple pulse diagnostic to a useful method of interrogating the nonlinear response of a material. Studies of nonlinear propagation are also performed in a regime where temporal pulse splitting occurs. Experimental results are compared with a three- dimensional nonlinear Schrödinger equation. This comparison fuels the development of a more complete model for pulse splitting. Experiments are also performed at peak input powers above those at which pulse splitting is observed. At these higher intensities, a broadband continuum is generated. This work presents a detailed study of continuum behavior and power loss as well as the first near-field spatial- spectral measurements of the generated continuum light. Nonlinear plane-wave propagation of short pulses in liquids is also investigated, and a non-instantaneous nonlinearity with a surprisingly short response time of 10 fs is observed in methanol. Experiments in water confirm that this effect in methanol is indeed real. Possible explanations for the observed effect are discussed and several are experimentally rejected. This thesis applies FROG as a powerful tool for science and not just a useful pulse diagnostic technique. Studies of three-dimensional propagation provide an in-depth understanding of the processes involved in femtosecond pulse splitting. In addition, the experimental investigations of continuum generation and pulse propagation in liquids provide new insights into the possible processes involved and should provide a useful comparison for developing theories.

Viewing past science from the point of view of present science, thereby illuminating both: Philosophy versus experiment in the work of Robert Boyle.

PubMed

Chalmers, Alan

2016-02-01

The seventeenth century witnessed the replacement of an Aristotelian worldview by a mechanical one. It also witnessed the beginnings of significant experimental enquiry. Alerted by the fact that the methods involved in the latter, but not in the former, resemble those employed in later science, I argue the historical case that the emergence of the mechanical worldview and the emergence of science were not closely related and that it was the latter that was to develop into science as we have come to know it. The details are explored in the context of the philosophical and experimental work of Robert Boyle and the relationship between them. Copyright © 2015 Elsevier Ltd. All rights reserved.

Characterizing Fracturing of Clay-Rich Lower Watrous Rock: From Laboratory Experiments to Nonlocal Damage-Based Simulations

NASA Astrophysics Data System (ADS)

Guy, N.; Seyedi, D. M.; Hild, F.

2018-06-01

The work presented herein aims at characterizing and modeling fracturing (i.e., initiation and propagation of cracks) in a clay-rich rock. The analysis is based on two experimental campaigns. The first one relies on a probabilistic analysis of crack initiation considering Brazilian and three-point flexural tests. The second one involves digital image correlation to characterize crack propagation. A nonlocal damage model based on stress regularization is used for the simulations. Two thresholds both based on regularized stress fields are considered. They are determined from the experimental campaigns performed on Lower Watrous rock. The results obtained with the proposed approach are favorably compared with the experimental results.

Compact Heat Exchanger Design and Testing for Advanced Reactors and Advanced Power Cycles

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sun, Xiaodong; Zhang, Xiaoqin; Christensen, Richard

The goal of the proposed research is to demonstrate the thermal hydraulic performance of innovative surface geometries in compact heat exchangers used as intermediate heat exchangers (IHXs) and recuperators for the supercritical carbon dioxide (s-CO 2) Brayton cycle. Printed-circuit heat exchangers (PCHEs) are the primary compact heat exchangers of interest. The overall objectives are: To develop optimized PCHE designs for different working fluid combinations including helium to s-CO 2, liquid salt to s-CO 2, sodium to s-CO 2, and liquid salt to helium; To experimentally and numerically investigate thermal performance, thermal stress and failure mechanism of PCHEs under various transients;more » and To study diffusion bonding techniques for elevated-temperature alloys and examine post-test material integrity of the PCHEs. The project objectives were accomplished by defining and executing five different tasks corresponding to these specific objectives. The first task involved a thorough literature review and a selection of IHX candidates with different surface geometries as well as a summary of prototypic operational conditions. The second task involved optimization of PCHE design with numerical analyses of thermal-hydraulic performances and mechanical integrity. The subsequent task dealt with the development of testing facilities and engineering design of PCHE to be tested in s-CO 2 fluid conditions. The next task involved experimental investigation and validation of the thermal-hydraulic performances and thermal stress distribution of prototype PCHEs manufactured with particular surface geometries. The last task involved an investigation of diffusion bonding process and posttest destructive testing to validate mechanical design methods adopted in the design process. The experimental work utilized the two test facilities at The Ohio State University (OSU) including one existing High-Temperature Helium Test Facility (HTHF) and the newly developed s-CO 2 test loop (STL) facility and s-CO 2 test facility at University of Wisconsin – Madison (UW).« less

Experimental and Numerical Study on Supersonic Ejectors Working with R-1234ze(E)

NASA Astrophysics Data System (ADS)

Kracik, Jan; Dvorak, Vaclav; Nguyen Van, Vu; Smierciew, Kamil

2018-06-01

These days, much effort is being put into lowering the consumption of electric energy and involving renewable energy sources. Many engineers and designers are trying to develop environment-friendly technologies worldwide. It is related to incorporating appropriate devices into such technologies. The object of this paper is to investigate these devices in connection with refrigeration systems. Ejectors can be considered such as these devices. The primary interest of this paper is to investigate the suitability of a numerical model for an ejector, which is incorporated into a refrigeration system. In the present paper, there have been investigated seven different test runs of working of the ejector with a working fluid R-1234ze(E). Some of the investigated cases seem to have a good agreement and there are no significant discrepancies between them, however, there are also cases that do not correspond to the experimental data at all. The ejector has been investigated in both on-design and off-design working modes. A comparison between the experimental and numerical data (CFD) performed by Ansys Fluent software is presented and discussed for both an ideal and a real gas model. In addition, an enhanced analytical model has been introduced for all runs of the ejector.

MicroGen: a MIAME compliant web system for microarray experiment information and workflow management.

PubMed

Burgarella, Sarah; Cattaneo, Dario; Pinciroli, Francesco; Masseroli, Marco

2005-12-01

Improvements of bio-nano-technologies and biomolecular techniques have led to increasing production of high-throughput experimental data. Spotted cDNA microarray is one of the most diffuse technologies, used in single research laboratories and in biotechnology service facilities. Although they are routinely performed, spotted microarray experiments are complex procedures entailing several experimental steps and actors with different technical skills and roles. During an experiment, involved actors, who can also be located in a distance, need to access and share specific experiment information according to their roles. Furthermore, complete information describing all experimental steps must be orderly collected to allow subsequent correct interpretation of experimental results. We developed MicroGen, a web system for managing information and workflow in the production pipeline of spotted microarray experiments. It is constituted of a core multi-database system able to store all data completely characterizing different spotted microarray experiments according to the Minimum Information About Microarray Experiments (MIAME) standard, and of an intuitive and user-friendly web interface able to support the collaborative work required among multidisciplinary actors and roles involved in spotted microarray experiment production. MicroGen supports six types of user roles: the researcher who designs and requests the experiment, the spotting operator, the hybridisation operator, the image processing operator, the system administrator, and the generic public user who can access the unrestricted part of the system to get information about MicroGen services. MicroGen represents a MIAME compliant information system that enables managing workflow and supporting collaborative work in spotted microarray experiment production.

Thermodynamically consistent relations involving plasticity, internal energy and thermal effects.

PubMed

Schreyer, H L; Maudlin, P J

2005-11-15

Experimental data associated with plastic deformations indicate that the temperature is less than that predicted from dissipation based on plastic work. To obtain reasonable correlation between theoretical and experimental results, the plastic work is often multiplied by a constant beta. This paper provides an alternative thermodynamic framework in which it is proposed that there is an additional internal energy associated with dislocation pile-up or increase in dislocation density. The form of this internal energy follows from experimental data that relates flow stress to dislocation density and to equivalent plastic strain. The result is that beta is not a constant but a derived function. Representative results for beta and temperature as functions of effective plastic strain are provided for both an uncoupled and a coupled thermoplastic theory. In addition to providing features that are believed to be representative of many metals, the formulation can be used as a basis for more advanced theories such as those needed for large deformations and general forms of internal energy.

The impact of genetically modified crops on soil microbial communities.

PubMed

Giovannetti, Manuela; Sbrana, Cristiana; Turrini, Alessandra

2005-01-01

Genetically modified (GM) plants represent a potential benefit for environmentally friendly agriculture and human health. Though, poor knowledge is available on potential hazards posed by unintended modifications occurring during genetic manipulation. The increasing amount of reports on ecological risks and benefits of GM plants stresses the need for experimental works aimed at evaluating the impact of GM crops on natural and agro-ecosystems. Major environmental risks associated with GM crops include their potential impact on non-target soil microorganisms playing a fundamental role in crop residues degradation and in biogeochemical cycles. Recent works assessed the effects of GM crops on soil microbial communities on the basis of case-by-case studies, using multimodal experimental approaches involving different target and non-target organisms. Experimental evidences discussed in this review confirm that a precautionary approach should be adopted, by taking into account the risks associated with the unpredictability of transformation events, of their pleiotropic effects and of the fate of transgenes in natural and agro-ecosystems, weighing benefits against costs.

Expressions for the spherical-wave-structure function based on a bump spectrum model for the index of refraction

NASA Astrophysics Data System (ADS)

Richardson, Christina E.; Andrews, Larry C.

1991-07-01

New spectra models have recently been developed for the spatial power spectra of temperature and refractive index fluctuations in the atmospheric boundary layer showing the characteristic 'bump' just prior to the dissipation ranges. Theoretical work involving these new models has led to new expressions for the phase structure function associated with a plane optical wave, although most experimental work has involved spherical waves. Following techniques similar to those used for the plane wave analysis, new expressions valid in geometrical and diffraction regimes are developed here for the phase structure function of a spherical optical wave propagating through clear-air atmospheric turbulence. Useful asymptotic formulas for small separation distances and the inertial subrange are derived from these general expressions.

Synthetic Development of Low Dimensional Materials

DOE PAGES

Men, Long; White, Miles A.; Andaraarachchi, Himashi; ...

2016-11-02

Here, in this invited paper, we highlight some of our most recent work on the synthesis of low dimensional nanomaterials. Current graduate students and members of our group present four specific case systems: Nowotny-Juza phases, nickel phosphides, germanium-based core/shells, and organolead mixed-halide perovskites. Each system is accompanied by commentary from the student involved, which explains our motivation behind our work, as well as by a protocol detailing the key experimental considerations involved in their synthesis. We trust these and similar efforts by others and us will help further advance our understanding of the broader field of synthetic nanomaterials chemistry, while,more » at the same time, highlighting how important this area is to the development of new materials for technologically relevant applications.« less

An Experimental Test of the Roles of Audience Involvement and Message Frame in Shaping Public Reactions to Celebrity Illness Disclosures.

PubMed

Myrick, Jessica Gall

2018-04-13

Much research has investigated what happens when celebrities disclose an illness (via media) to the public. While audience involvement (i.e., identification and parasocial relationships) is often the proposed mechanism linking illness disclosures with audience behavior change, survey designs have prevented researchers from understanding if audience involvement prior to the illness disclosure actually predicts post-disclosure emotions, cognitions, and behaviors. Rooted in previous work on audience involvement as well as the Extended Parallel Process Model, the present study uses a national online experiment (N = 1,068) to test how pre-disclosure audience involvement may initiate post-disclosure effects for the message context of skin cancer. The data demonstrate that pre-disclosure audience involvement as well as the celebrity's framing of the disclosure can shape emotional responses (i.e., fear and hope), and that cognitive perceptions of the illness itself also influence behavioral intentions.

Faculty Member for Research in an Undergraduate Institution Prize Talk: Research and Teaching through high-precision spectroscopy of heavy atoms

NASA Astrophysics Data System (ADS)

Majumder, Tiku

2017-04-01

In recent decades, substantial experimental effort has centered on heavy (high-Z) atomic and molecular systems for atomic-physics-based tests of standard model physics, through (for example) measurements of atomic parity nonconservation and searches for permanent electric dipole moments. In all of this work, a crucial role is played by atomic theorists, whose accurate wave function calculations are essential in connecting experimental observables to tests of relevant fundamental physics parameters. At Williams College, with essential contributions from dozens of undergraduate students, we have pursued a series of precise atomic structure measurements in heavy metal atoms such as thallium, indium, and lead. These include measurements of hyperfine structure, transition amplitudes, and atomic polarizability. This work, involving diode lasers, heated vapor cells, and an atomic beam apparatus, has both tested the accuracy and helped guide the refinement of new atomic theory calculations. I will discuss a number of our recent experimental results, emphasizing the role played by students and the opportunities that have been afforded for research-training in this undergraduate environment. Work supported by Research Corporation, the NIST Precision Measurement Grants program, and the National Science Foundation.

What Works for Civic Engagement: Lessons from Experimental Evaluations of Programs and Interventions. Fact Sheet. Publication #2008-22

ERIC Educational Resources Information Center

Rivers, Andrew; Moore, Kristin A.

2008-01-01

Civic engagement and participation are central to the functioning of a democratic society. In addition, young people who are involved in civic activities are more engaged in academics, are less likely to participate in risky behaviors, and more than likely continue on to adulthood as contributing members of their communities. Rates of young…

Involvement and Making Movies: A Study of the Introduction of Movie Making to Poverty Boys. Final Report.

ERIC Educational Resources Information Center

Durkin, Roderick

Advocates of movie making believe that it provides a non-ethnocentric experience that is inherently engaging and relatively free from the risk of failure. Disadvantaged teenage boys who were attending two experimental summer work camps participated in studies of two aspects of movie making. The first study evaluated three different techniques for…

Computer Use and Its Effect on the Memory Process in Young and Adults

ERIC Educational Resources Information Center

Alliprandini, Paula Mariza Zedu; Straub, Sandra Luzia Wrobel; Brugnera, Elisangela; de Oliveira, Tânia Pitombo; Souza, Isabela Augusta Andrade

2013-01-01

This work investigates the effect of computer use in the memory process in young and adults under the Perceptual and Memory experimental conditions. The memory condition involved the phases acquisition of information and recovery, on time intervals (2 min, 24 hours and 1 week) on situations of pre and post-test (before and after the participants…

What Works for Parent Involvement Programs for Children: Lessons from Experimental Evaluations of Social Interventions. Fact Sheet. Publication #2009-47

ERIC Educational Resources Information Center

Mbwana, Kassim; Terzian, Mary; Moore, Kristin A.

2009-01-01

Child health and well-being are intrinsically important and also contribute to a healthy, productive adolescence and adulthood. Parents can play an important role in helping their children acquire or strengthen the behaviors, skills, attitudes, and motivation that promote physical and mental health and overall well-being in childhood, adolescence…

Introducing Experimental Design by Evaluating Efficacy of Herbal Remedies (Do Herbal Remedies Really Work?)

ERIC Educational Resources Information Center

Smith, Robert A.; Pontiggia, Laura; Waterman, Carrie; Lichtenwalner, Meghan

2010-01-01

This paper is based upon experiments developed as part of a Directed Research course designed to provide undergraduate biology students experience in the principles and processes of the scientific method used in biological research. The project involved the evaluation of herbal remedies used in many parts of the world in the treatment of diseases…

What Works for Parent Involvement Programs for Adolescents: Lessons from Experimental Evaluations of Social Interventions. Fact Sheet. Publication #2009-48

ERIC Educational Resources Information Center

Terzian, Mary; Mbwana, Kassim

2009-01-01

Adopting healthy and positive behaviors and avoiding risky ones are key developmental tasks of adolescence. Parents can play an important role in helping their adolescent children acquire or strengthen the behaviors, skills, attitudes, and motivation that promote physical and mental health and overall well-being. Recognizing this, a variety of…

Analysis of castellated steel beam with oval openings

NASA Astrophysics Data System (ADS)

Tudjono, S.; Sunarto; Han, A. L.

2017-11-01

A castellated steel beam is per definition a wide flange (WF) or I shaped steel profile with openings, to reduce self-weight and improve the effectiveness in terms of material use. Recently, extensive study on these castellated steel beams has been conducted, involving different shapes in web openings. The main goal of these research works was to evaluate and analyze its optimum opening sizes and shapes configuration. More in-depth research work to the behavior and the influence of holes to WF beams need to be conducted. In this paper, an oval shaped web opening is chosen as alternate. The study involves a modification in the variation of oval web openings both in the horizontally and vertically direction. An experimental and numerical study based on the finite element method conducted with the Abaqus/CAE 6.12 software is used to analyze the buckling behavior of the web. The obtained results from the experimental test specimens are in good agreement with the obtained results from the finite element analysis. Furthermore, the numerical model can be expanded to be used as analyzing tool in evaluating and studying the effect and influencing factors of a variation in opening’s parameters.

Final Technical Report for Department of Energy award number DE-FG02-06ER54882, Revised

DOE Office of Scientific and Technical Information (OSTI.GOV)

Eggleston, Dennis L.

The research reported here involves studies of radial particle transport in a cylindrical, low-density Malmberg-Penning non-neutral plasma trap. The research is primarily experimental but involves careful comparisons to analytical theory and includes the results of a single-particle computer code. The transport is produced by applied electric fields that break the cylindrical symmetry of the trap, hence the term ``asymmetry-induced transport.'' Our computer studies have revealed the importance of a previously ignored class of particles that become trapped in the asymmetry potential. In many common situations these particles exhibit large radial excursions and dominate the radial transport. On the experimental side,more » we have developed new data analysis techniques that allowed us to determine the magnetic field dependence of the transport and to place empirical constraints on the form on the transport equation. Experiments designed to test the computer code results gave varying degrees of agreement with further work being necessary to understand the results. This work expands our knowledge of the varied mechanisms of cross-magnetic-field transport and should be of use to other workers studying plasma confinement.« less

Effect of herd cues and product involvement on bidder online choices.

PubMed

Chen, Yi-Fen; Wang, Ya-Ju

2010-08-01

Previous works have shown that consumers are influenced by others in decision making. Herd behavior is common in situations in which consumers infer product quality from other consumer choices and incorporate that information into their own decision making. This research presents two studies examining herd effect and the moderating role of product involvement on bidder choices in online auctions. The two studies addressed the influence on bidder online choices of herd cues frequently found in online auctions, including feedback ratings and number of questions and answers. The experimental results demonstrated that bidders use online herd cues when making decisions in online auctions. Additionally, the effects of herd cues on bidder online choices were stronger in high-involvement than low-involvement participants. Results and implications are discussed.

Emotional Modulation of Learning and Memory: Pharmacological Implications.

PubMed

LaLumiere, Ryan T; McGaugh, James L; McIntyre, Christa K

2017-07-01

Memory consolidation involves the process by which newly acquired information becomes stored in a long-lasting fashion. Evidence acquired over the past several decades, especially from studies using post-training drug administration, indicates that emotional arousal during the consolidation period influences and enhances the strength of the memory and that multiple different chemical signaling systems participate in this process. The mechanisms underlying the emotional influences on memory involve the release of stress hormones and activation of the basolateral amygdala, which work together to modulate memory consolidation. Moreover, work suggests that this amygdala-based memory modulation occurs with numerous types of learning and involves interactions with many different brain regions to alter consolidation. Additionally, studies suggest that emotional arousal and amygdala activity in particular influence synaptic plasticity and associated proteins in downstream brain regions. This review considers the historical understanding for memory modulation and cellular consolidation processes and examines several research areas currently using this foundational knowledge to develop therapeutic treatments. Copyright © 2017 by The American Society for Pharmacology and Experimental Therapeutics.

Experimental confirmation of a PDE-based approach to design of feedback controls

NASA Technical Reports Server (NTRS)

Banks, H. T.; Smith, Ralph C.; Brown, D. E.; Silcox, R. J.; Metcalf, Vern L.

1995-01-01

Issues regarding the experimental implementation of partial differential equation based controllers are discussed in this work. While the motivating application involves the reduction of vibration levels for a circular plate through excitation of surface-mounted piezoceramic patches, the general techniques described here will extend to a variety of applications. The initial step is the development of a PDE model which accurately captures the physics of the underlying process. This model is then discretized to yield a vector-valued initial value problem. Optimal control theory is used to determine continuous-time voltages to the patches, and the approximations needed to facilitate discrete time implementation are addressed. Finally, experimental results demonstrating the control of both transient and steady state vibrations through these techniques are presented.

Characterizing new compositions of [001]C relaxor ferroelectric single crystals using a work-energy model

NASA Astrophysics Data System (ADS)

Gallagher, John A.

2016-04-01

The desired operating range of ferroelectric materials with compositions near the morphotropic phase boundary is limited by field induced phase transformations. In [001]C cut and poled relaxor ferroelectric single crystals the mechanically driven ferroelectric rhombohedral to ferroelectric orthorhombic phase transformation is hindered by antagonistic electrical loading. Instability around the phase transformation makes the current experimental technique for characterization of the large field behavior very time consuming. Characterization requires specialized equipment and involves an extensive set of measurements under combined electrical, mechanical, and thermal loads. In this work a mechanism-based model is combined with a more limited set of experiments to obtain the same results. The model utilizes a work-energy criterion that calculates the mechanical work required to induce the transformation and the required electrical work that is removed to reverse the transformation. This is done by defining energy barriers to the transformation. The results of the combined experiment and modeling approach are compared to the fully experimental approach and error is discussed. The model shows excellent predictive capability and is used to substantially reduce the total number of experiments required for characterization. This decreases the time and resources required for characterization of new compositions.

RN work engagement in generational cohorts: the view from rural US hospitals.

PubMed

Sullivan Havens, Donna; Warshawsky, Nora E; Vasey, Joseph

2013-10-01

To describe staff nurse work engagement, identify predictors by generational cohort, present implications for nurse managers and suggest future research. A global nurse shortage looms. While an adequate supply of nurses is needed to ensure access to care, access to quality care may be enhanced by an adequate supply of highly engaged nurses-those who are dedicated, energized, and absorbed. Nurses have long reported the presence of energy depleting practice environments. Nurses practicing in professional practice environments may be more engaged. A non-experimental survey design was executed. Direct care Registered Nurses (n = 747) working in five rural acute care hospitals completed questionnaires to assess work engagement (Utrecht Work Engagement Scale-9), decisional involvement (Decisional Involvement Scale), relational coordination (Relational Coordination Survey) and the nursing practice environment (Practice Environment Scale of the Nursing Work Index). Descriptive, correlational and regression analyses examined work engagement and predictors by generational cohort. With the exception of the absorption component, no statistically significant differences in engagement emerged across generational cohorts. Predictors of engagement differed by cohort, however across all cohorts, professional nursing practice environments predicted nurse work engagement. Professional nursing practice environments are significantly associated with nurse work engagement. Enhancing nurse work engagement is a complex challenge. Generational cohorts may respond to different strategies to enhance engagement. © 2013 John Wiley & Sons Ltd.

[The development of organizational comfort: organizational training as strategic instrument for changing].

PubMed

Stocchi, M; Giobbe, T; Boscolo, P; Di Giampaolo, P; Di Giampaolo, L

2010-01-01

The organizational comfort has been defined as the relationship between people and work environment. The supervisor's functions imply organizing and relation competences, listening and observation, communication and negotiation. Unfortunately, the reality is quite different: there are often situations of communication disorder between the supervisor and the worker, where the first, unaware of his role and responsibility, doesn't understand the worker's needs, doesn't communicate rightly the risk, doesn't develop any emphatic attitude and organize work without thinking to individual inclinations and limitations. The worker perceives this situation as increasing sensation of tiredness and working stress. The workers, often involved in this organization, have to ask overtime medical examinations to obtain some limitations. Observing this big increase of limitations in some firms with working people relatively young, we have decided to elaborate an experimental project involving both the occupational doctor and the psychologist. We analyzed the relations between the supervisor and the worker, with the aim to increase organizational comfort, through the diffusion of anonymous questionnaires or training courses about behaviour analyses and communication strategies, verifying any possible modifications of the organization after our intervention.

Incubation and Intuition in Creative Problem Solving.

PubMed

Gilhooly, Kenneth J

2016-01-01

Creative problem solving, in which novel solutions are required, has often been seen as involving a special role for unconscious processes (Unconscious Work) which can lead to sudden intuitive solutions (insights) when a problem is set aside during incubation periods. This notion of Unconscious Work during incubation periods is supported by a review of experimental studies and particularly by studies using the Immediate Incubation paradigm. Other explanations for incubation effects, in terms of Intermittent Work or Beneficial Forgetting are considered. Some recent studies of divergent thinking, using the Alternative Uses task, carried out in my laboratory regarding Immediate vs. Delayed Incubation and the effects of resource competition from interpolated activities are discussed. These studies supported a role for Unconscious Work as against Intermittent Conscious work or Beneficial Forgetting in incubation.

Incubation and Intuition in Creative Problem Solving

PubMed Central

Gilhooly, Kenneth J.

2016-01-01

Creative problem solving, in which novel solutions are required, has often been seen as involving a special role for unconscious processes (Unconscious Work) which can lead to sudden intuitive solutions (insights) when a problem is set aside during incubation periods. This notion of Unconscious Work during incubation periods is supported by a review of experimental studies and particularly by studies using the Immediate Incubation paradigm. Other explanations for incubation effects, in terms of Intermittent Work or Beneficial Forgetting are considered. Some recent studies of divergent thinking, using the Alternative Uses task, carried out in my laboratory regarding Immediate vs. Delayed Incubation and the effects of resource competition from interpolated activities are discussed. These studies supported a role for Unconscious Work as against Intermittent Conscious work or Beneficial Forgetting in incubation. PMID:27499745

Estimation of hydrogen sulfide emission rates at several wastewater treatment plants through experimental concentration measurements and dispersion modeling.

PubMed

Llavador Colomer, Fernando; Espinós Morató, Héctor; Mantilla Iglesias, Enrique

2012-07-01

The management and operation of wastewater treatment plants (WWTP) usually involve the release into the atmosphere of malodorous substances with the potential to reduce the quality of life of people living nearby. In this type of facility, anaerobic degradation processes contribute to the generation of hydrogen sulfide (H2S), often at quite high concentrations; thus, the presence of this chemical compound in the atmosphere can be a good indicator of the occurrence and intensity of the olfactory impact in a specific area. The present paper describes the experimental and modelling work being carried out by CEAM-UMH in the surroundings of several wastewater treatment plants located in the Valencia Autonomous Community (Spain). This work has permitted the estimation of H2S emission rates at different WWTPs under different environmental and operating conditions. Our methodological approach for analyzing and describing the most relevant aspects of the olfactory impact consisted of several experimental campaigns involving intensive field measurements using passive samplers in the vicinity of several WWTPs, in combination with numerical simulation results from a diagnostic dispersion model. A meteorological tower at each WWTP provided the input values for the dispersion code, ensuring a good fit of the advective component and therefore more confidence in the modelled concentration field in response to environmental conditions. Then, comparisons between simulated and experimental H2S concentrations yielded estimates of the global emission rate for this substance at several WWTPs at different time periods. The results obtained show a certain degree of temporal and spatial (between-plant) variability (possibly due to both operational and environmental conditions). Nevertheless, and more importantly, the results show a high degree of uniformity in the estimates, which consistently stay within the same order of magnitude.

The effect of work-time influence on health and well-being: a quasi-experimental intervention study among eldercare workers.

PubMed

Nabe-Nielsen, Kirsten; Garde, Anne Helene; Diderichsen, Finn

2011-08-01

The aim of this study was to investigate the effect of work-time influence on stress and energy, work-family conflicts, lifestyle factors, and biomarkers of cardiovascular disease risk. The study was a quasi-experimental intervention study with a one-year follow-up among eldercare workers (baseline: n = 309; follow-up: n = 297). The nine work units in the intervention group designed their own intervention. We categorized these work units into three subgroups according to the interventions that they initiated: (A) self-scheduling via a computer program (n = 35), (B) setting up a task group that developed a questionnaire on work-time preference and participated in a one-day course on flexible working hours with the intention to increase employee influence on the fixed rota (n = 62), and (C) discussions of how employee work-time influence could be increased (n = 25). These subgroups were compared with a reference group consisting of ten work units (n = 187). Data consisted of questionnaires, blood samples, and measurements of waist and hip circumference. The employees in subgroup A became increasingly involved in the planning of their own work schedule. Nevertheless, we found no effect on health and well-being attributable to the intervention. The introduction of self-scheduling can successfully increase employee work-time influence. Yet, this study does not support the theory that increased work-time influence leads to better health and well-being.

Student Collaboration in a Series of Integrated Experiments to Study Enzyme Reactor Modeling with Immobilized Cell-Based Invertase

ERIC Educational Resources Information Center

Taipa, M. A^ngela; Azevedo, Ana M.; Grilo, Anto´nio L.; Couto, Pedro T.; Ferreira, Filipe A. G.; Fortuna, Ana R. M.; Pinto, Ine^s F.; Santos, Rafael M.; Santos, Susana B.

2015-01-01

An integrative laboratory study addressing fundamentals of enzyme catalysis and their application to reactors operation and modeling is presented. Invertase, a ß-fructofuranosidase that catalyses the hydrolysis of sucrose, is used as the model enzyme at optimal conditions (pH 4.5 and 45 °C). The experimental work involves 3 h of laboratory time…

Norms and the Perception of Events

DTIC Science & Technology

1992-01-31

Experimental Psychology: Human Perception and Performance. 12, 1986, 445-454. Brickman, P., and D.T. Campbell. Hedonic relativism and planning the good ...interesting problem, which we plan to explore in further work. Table 1-3 presents results for conditions involving objects, actions and changes. We...following stem completion appeared: Alfred’s performance on the fourth afternoon was [] Very Good [I Good [] Fairly Good [I Nothing Special [] Rather Bad

Research Results and Final Report for the Dispute Management in the Schools Project. PCR Working Paper Series.

ERIC Educational Resources Information Center

Araki, Charles T.; And Others

To develop and test an experimental model of dispute or conflict management through mediation in a school complex, and to examine the basic nature of conflict in schools, the Dispute Management in the Schools Project (DMSP) was conducted. The 3-year mediation project, begun in January 1986, involved an elementary school, an intermediate school, a…

Experimental Evidence on the Effects of Home Computers on Academic Achievement among Schoolchildren. National Poverty Center Working Paper Series #13-02

ERIC Educational Resources Information Center

Fairlie, Robert W.; Robinson, Jonathan

2013-01-01

Computers are an important part of modern education, yet large segments of the population--especially low-income and minority children--lack access to a computer at home. Does this impede educational achievement? We test this hypothesis by conducting the largest-ever field experiment involving the random provision of free computers for home use to…

Vestibular-visual interactions in flight simulators

NASA Technical Reports Server (NTRS)

Clark, B.

1977-01-01

All 139 research papers published under this ten-year program are listed. Experimental work was carried out at the Ames Research Center involving man's sensitivity to rotational acceleration, and psychophysical functioning of the semicircular canals; vestibular-visual interactions and effects of other sensory systems were studied in flight simulator environments. Experiments also dealt with the neurophysiological vestibular functions of animals, and flight management investigations of man-vehicle interactions.

Experimental and theoretical investigation on the molecular structure, spectroscopic and electric properties of 2,4-dinitrodiphenylamine, 2-nitro-4-(trifluoromethyl)aniline and 4-bromo-2-nitroaniline

NASA Astrophysics Data System (ADS)

Hernández-Paredes, Javier; Hernández-Negrete, Ofelia; Carrillo-Torres, Roberto C.; Sánchez-Zeferino, Raúl; Duarte-Moller, Alberto; Alvarez-Ramos, Mario E.

2015-10-01

2,4-Dinitrodiphenylamine (I), 2-nitro-4-(trifluoromethyl)aniline (II) and 4-bromo-2-nitroaniline (III) have been investigated by DFT and experimental FTIR, Raman and UV-Vis spectroscopies. The gas-phase molecular geometries were consistent with similar compounds already reported in the literature. From the vibrational analysis, the main functional groups were identified and their absorption bands were assigned. Some differences were found between the calculated and the experimental UV-Vis spectra. These differences were analyzed and explained in terms of the TD-DFT/B3LYP limitations, which were mainly attributed to charge-transfer (CT) effects. These findings were in agreement with previous works, which reported that TD-DFT/B3LYP calculations diverge from experimental results when the electronic transitions involve CT. Despite this, TD-DFT/B3LYP calculations provided satisfactory results and a detailed description of the electronic transitions involved in the absorption bands of the UV-Vis spectra. In terms of the NLO properties, it was found that compound (I) is a good candidate for NLO applications and deserves further study due to its good β values. However, the β values for compounds (II) and (III) were negatively affected compared to those found on o-nitroaniline.

Experimental manipulation of psychosocial exposure and questionnaire sensitivity in a simulated manufacturing setting.

PubMed

Ikuma, Laura H; Babski-Reeves, Kari; Nussbaum, Maury A

2009-05-01

The objectives of this study were to determine the efficacy of experimental manipulations of psychosocial exposures and to evaluate the sensitivity of a psychosocial questionnaire by determining the factors perceived. A 50-item questionnaire was developed from the job content questionnaire (JCQ) and the quality of worklife survey (QWL). The experiment involved simulated work at different physical and psychosocial levels. Forty-eight participants were exposed to two levels of one psychosocial manipulation (job control, job demands, social support, or time pressure). Significantly different questionnaire responses supported the effectiveness of psychosocial manipulations. Exploratory factor analysis revealed five factors: skill discretion and decision authority, stress level and supervisor support, physical demands, quality of coworker support, and decision-making support. These results suggest that psychosocial factors can be manipulated experimentally, and that questionnaires can distinguish perceptions of these factors. These questionnaires may be used to assess perceptions of psychosocial factors in experimental settings.

Improved Subcell Model for the Prediction of Braided Composite Response

NASA Technical Reports Server (NTRS)

Cater, Christopher R.; Xinran, Xiao; Goldberg, Robert K.; Kohlman, Lee W.

2013-01-01

In this work, the modeling of triaxially braided composites was explored through a semi-analytical discretization. Four unique subcells, each approximated by a "mosaic" stacking of unidirectional composite plies, were modeled through the use of layered-shell elements within the explicit finite element code LS-DYNA. Two subcell discretizations were investigated: a model explicitly capturing pure matrix regions, and a novel model which absorbed pure matrix pockets into neighboring tow plies. The in-plane stiffness properties of both models, computed using bottom-up micromechanics, correlated well to experimental data. The absorbed matrix model, however, was found to best capture out-of- plane flexural properties by comparing numerical simulations of the out-of-plane displacements from single-ply tension tests to experimental full field data. This strong correlation of out-of-plane characteristics supports the current modeling approach as a viable candidate for future work involving impact simulations.

Broadband polygonal invisibility cloak for visible light

PubMed Central

Chen, Hongsheng; Zheng, Bin

2012-01-01

Invisibility cloaks have recently become a topic of considerable interest thanks to the theoretical works of transformation optics and conformal mapping. The design of the cloak involves extreme values of material properties and spatially dependent parameter tensors, which are very difficult to implement. The realization of an isolated invisibility cloak in the visible light, which is an important step towards achieving a fully movable invisibility cloak, has remained elusive. Here, we report the design and experimental demonstration of an isolated polygonal cloak for visible light. The cloak is made of several elements, whose electromagnetic parameters are designed by a linear homogeneous transformation method. Theoretical analysis shows the proposed cloak can be rendered invisible to the rays incident from all the directions. Using natural anisotropic materials, a simplified hexagonal cloak which works for six incident directions is fabricated for experimental demonstration. The performance is validated in a broadband visible spectrum. PMID:22355767

Numerical Analysis of Heat Transfer During Quenching Process

NASA Astrophysics Data System (ADS)

Madireddi, Sowjanya; Krishnan, Krishnan Nambudiripad; Reddy, Ammana Satyanarayana

2018-04-01

A numerical model is developed to simulate the immersion quenching process of metals. The time of quench plays an important role if the process involves a defined step quenching schedule to obtain the desired characteristics. Lumped heat capacity analysis used for this purpose requires the value of heat transfer coefficient, whose evaluation requires large experimental data. Experimentation on a sample work piece may not represent the actual component which may vary in dimension. A Fluid-Structure interaction technique with a coupled interface between the solid (metal) and liquid (quenchant) is used for the simulations. Initial times of quenching shows boiling heat transfer phenomenon with high values of heat transfer coefficients (5000-2.5 × 105 W/m2K). Shape of the work piece with equal dimension shows less influence on the cooling rate Non-uniformity in hardness at the sharp corners can be reduced by rounding off the edges. For a square piece of 20 mm thickness, with 3 mm fillet radius, this difference is reduced by 73 %. The model can be used for any metal-quenchant combination to obtain time-temperature data without the necessity of experimentation.

Sensor-Based Human Activity Recognition in a Multi-user Scenario

NASA Astrophysics Data System (ADS)

Wang, Liang; Gu, Tao; Tao, Xianping; Lu, Jian

Existing work on sensor-based activity recognition focuses mainly on single-user activities. However, in real life, activities are often performed by multiple users involving interactions between them. In this paper, we propose Coupled Hidden Markov Models (CHMMs) to recognize multi-user activities from sensor readings in a smart home environment. We develop a multimodal sensing platform and present a theoretical framework to recognize both single-user and multi-user activities. We conduct our trace collection done in a smart home, and evaluate our framework through experimental studies. Our experimental result shows that we achieve an average accuracy of 85.46% with CHMMs.

Cetacean vocal learning and communication.

PubMed

Janik, Vincent M

2014-10-01

The cetaceans are one of the few mammalian clades capable of vocal production learning. Evidence for this comes from synchronous changes in song patterns of baleen whales and experimental work on toothed whales in captivity. While baleen whales like many vocal learners use this skill in song displays that are involved in sexual selection, toothed whales use learned signals in individual recognition and the negotiation of social relationships. Experimental studies demonstrated that dolphins can use learned signals referentially. Studies on wild dolphins demonstrated how this skill appears to be useful in their own communication system, making them an interesting subject for comparative communication studies. Copyright © 2014. Published by Elsevier Ltd.

A new statistical method for transfer coefficient calculations in the framework of the general multiple-compartment model of transport for radionuclides in biological systems.

PubMed

Garcia, F; Arruda-Neto, J D; Manso, M V; Helene, O M; Vanin, V R; Rodriguez, O; Mesa, J; Likhachev, V P; Filho, J W; Deppman, A; Perez, G; Guzman, F; de Camargo, S P

1999-10-01

A new and simple statistical procedure (STATFLUX) for the calculation of transfer coefficients of radionuclide transport to animals and plants is proposed. The method is based on the general multiple-compartment model, which uses a system of linear equations involving geometrical volume considerations. By using experimentally available curves of radionuclide concentrations versus time, for each animal compartment (organs), flow parameters were estimated by employing a least-squares procedure, whose consistency is tested. Some numerical results are presented in order to compare the STATFLUX transfer coefficients with those from other works and experimental data.

A model for sequential decoding overflow due to a noisy carrier reference. [communication performance prediction

NASA Technical Reports Server (NTRS)

Layland, J. W.

1974-01-01

An approximate analysis of the effect of a noisy carrier reference on the performance of sequential decoding is presented. The analysis uses previously developed techniques for evaluating noisy reference performance for medium-rate uncoded communications adapted to sequential decoding for data rates of 8 to 2048 bits/s. In estimating the ten to the minus fourth power deletion probability thresholds for Helios, the model agrees with experimental data to within the experimental tolerances. The computational problem involved in sequential decoding, carrier loop effects, the main characteristics of the medium-rate model, modeled decoding performance, and perspectives on future work are discussed.

Stokes's Cradle: Newton's Cradle with Liquid Coating

NASA Astrophysics Data System (ADS)

Donahue, C. M.; Hrenya, C. M.; Davis, R. H.

2010-07-01

Granular flows involving liquid-coated solids are ubiquitous in nature (pollen capture, avalanches) and industry (filtration, pharmaceutical mixing). In this Letter, three-body collisions between liquid-coated spheres are investigated experimentally using a “Stokes’s cradle,” which resembles the popular desktop toy Newton’s cradle (NC). Surprisingly, previous work shows that every possible outcome was observed in the Stokes’s cradle except the traditional NC outcome. Here, we experimentally achieve NC via guidance from a theory, which revealed that controlling the liquid-bridge volume connecting two target particles is the key in attaining the NC outcome. These three-body experiments also provide direct evidence that the fluid resistance upon rebound cannot be completely neglected due to presumed cavitation; this resistance also influences two-body systems yet cannot be isolated experimentally in such systems.

Flooding Fragility Experiments and Prediction

DOE Office of Scientific and Technical Information (OSTI.GOV)

Smith, Curtis L.; Tahhan, Antonio; Muchmore, Cody

2016-09-01

This report describes the work that has been performed on flooding fragility, both the experimental tests being carried out and the probabilistic fragility predictive models being produced in order to use the text results. Flooding experiments involving full-scale doors have commenced in the Portal Evaluation Tank. The goal of these experiments is to develop a full-scale component flooding experiment protocol and to acquire data that can be used to create Bayesian regression models representing the fragility of these components. This work is in support of the Risk-Informed Safety Margin Characterization (RISMC) Pathway external hazards evaluation research and development.

Composite Fuselage Technology

NASA Technical Reports Server (NTRS)

Lagace, Paul A.

1999-01-01

Work was conducted over a ten-year period to address the central issue of damage in primary load-bearing aircraft composite structure, specifically fuselage structure. This included the three facets of damage resistance, damage tolerance, and damage arrest. Experimental, analytical, and numerical work was conducted in order to identify and better understand the mechanisms that control the structural behavior of fuselage structures in their response to the three aspects of damage. Furthermore, work was done to develop straightforward design methodologies that can be employed by structural designers in preliminary design stages to make intelligent choices concerning the material, layup, and structural configurations so that a more efficient structure with structural integrity can be designed and built. Considerable progress was made towards achieving these goals via this work. In regard to damage tolerance considerations, the following were identified as important effects: composite layup and associated orthotropy/structural anisotropy, specifics of initial local damage mechanisms, role of longitudinal versus hoop stress, and large deformation and associated geometric nonlinearity. Means were established to account for effects of radius and for the nonlinear response. In particular, nondimensional parameters were identified to characterize the importance of nonlinearity in the response of pressurized cylinders. This led to the establishment of a iso-nonlinear-error plot for reference in structural design. Finally, in the case of damage tolerance, the general approach of the original methodology to predict the failure pressure involving extending basic plate failure data by accounting for the local stress intensification was accomplished for the general case by accounting for the mechanisms noted by utilizing the capability of the STAGS finite element code and numerically calculating the local stress intensification for the particular configuration to be considered. For the issue of damage arrest, placement of and configuration of stiffeners (including stiffener curvature), and magnitude and orientation of principal strains due to local bending were found to be key considerations. Means were established to account for stiffener effectiveness quantitatively based on radius, slit size, stiffener curvature' and relative bending stifffiesses involved. Geometric nonlinearity was also found to play an - 24 - important role here. Furthermore, it was determined that damage propagation is controlled by different mechanisms (hoop stress versus flapping stress and the associated factors involved in each) depending upon the direction of damage propagation. This latter item results in an inability to scale these phenomena in one test due to the different factors involved. Finally, the importance of shell curvature and associated instability in response to transverse loading including impact were found to be important considerations in damage resistance. A technique, involving asymmetric meshing of a finite element mesh, was developed to predict this behavior and showed excellent correlation with experimental results. Further details of these ten years of work are presented herein with references made to the fourteen documents produced during this work where full details can be found. Implications of this work are discussed and recommendations made. Although it is clear that there is more work to be done to fully understand composite fuselage technology and specifically the overall issue of damage in primary load-bearing composite structures, important understanding and capability has been extended via this work.

Enthalpy measurement of coal-derived liquids. Technical progress report, August-October 1982

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kidnay, A.J.; Yesavage, V.F.

The correlational effort on the coal syncrudes and model compounds has been proceeding along two fronts. The first involves experimental work on a correlating factor for association in the liquids and the second involves an investigation of the modeling capabilities of cubic equations of state. The first area of investigation is the experimental measurement of a correlating factor for assocition in coal liquids. The procedure involves molecular weight measurement by freezing point depression. To facilitate these measurements, a simple Beckman freezing point depression apparatus is being currently modified to increase the accuracy, speed, and ease of measurement. The second areamore » of effort has involved establishing a set of cubic equations of state which can adequately model the enthalpy departures of quinoline and m-cresol. To this effort, a number of standard and association specific equations of state have been tested against a data base of previously measured enthalpy departures of m-cresol and quinoline. It has been found that these equations do quantitatively a poor job on m-cresol and quinoline. These problems are probably due to the highly polar nature of m-cresol and to a lesser extent quinoline, and to the poor quality of critical parameters for quinoline.« less

The Intersection of Theory and Application in Elucidating Pattern Formation in Developmental Biology

PubMed Central

Othmer, Hans G.; Painter, Kevin; Umulis, David; Xue, Chuan

2009-01-01

We discuss theoretical and experimental approaches to three distinct developmental systems that illustrate how theory can influence experimental work and vice-versa. The chosen systems – Drosophila melanogaster, bacterial pattern formation, and pigmentation patterns – illustrate the fundamental physical processes of signaling, growth and cell division, and cell movement involved in pattern formation and development. These systems exemplify the current state of theoretical and experimental understanding of how these processes produce the observed patterns, and illustrate how theoretical and experimental approaches can interact to lead to a better understanding of development. As John Bonner said long ago ‘We have arrived at the stage where models are useful to suggest experiments, and the facts of the experiments in turn lead to new and improved models that suggest new experiments. By this rocking back and forth between the reality of experimental facts and the dream world of hypotheses, we can move slowly toward a satisfactory solution of the major problems of developmental biology.’ PMID:19844610

Training Manpower Development Work Supervisors in the Use of Behavior Modification Techniques to Teach Job-Required Skills. Special Report.

ERIC Educational Resources Information Center

Neiswender, Lenore

The paper describes a current research project now being conducted by the Experimental Manpower Laboratory at Mobilization for Youth (MFY-EML) in New York City. The overall objective of the MFY-EML is to develop and test new methods of teaching vocational skills to hard-to-employ youth. The MFY-EML is involved in developing a program to teach…

Final Evaluation Report of the 1970-1971 Group C-Kindergarten Education Programs, Districts Number 4, 5, 9, 27. ESEA Title I.

ERIC Educational Resources Information Center

Bertoldi, Arthur; Duphiney, Lorna

A differentiated staffing model involving the use of adult educational assistants to work with the kindergarten teacher and children within the classroom was utilized as the experimental concept for an Early Childhood project funded under Title I of the 1965 Elementary Secondary Education Act in the 1970-71 school year. The primary purpose of the…

Aeropropulsion 1987. Session 3: Internal Fluid Mechanics Research

NASA Technical Reports Server (NTRS)

1987-01-01

Internal fluid mechanics research at Lewis is directed toward an improved understanding of the important flow physics affecting aerospace propulsion systems, and applying this improved understanding to formulate accurate predictive codes. To this end, research is conducted involving detailed experimentation and analysis. The presentations in this session summarize ongoing work and indicated future emphasis in three major research thrusts: namely, inlets, ducts, and nozzles; turbomachinery; and chemical reacting flows.

Using concept building in optics to improve student research skills

NASA Astrophysics Data System (ADS)

Masters, Mark F.; Grove, Timothy T.

2014-07-01

Optics is a core component of an undergraduate physics degree. Not only is optics a fascinating topic on its own, but a good understanding of optics helps students gain valuable insight into more complex topics. A working knowledge of optics is vital for the experimental investigation of astronomy, quantum mechanics, and a host of other research endeavors involving optical measurements. Research is also a critical part of a student's education. Participation in research brings tremendous benefits to a student. So what do the students gain by participation in research? They learn independence. They learn how to plan a project. They learn the process of discovery. They learn that all answers are not always found on the internet, from professors, in books and publications (in that order). Research makes the "book" learning real. But what skills do the students need to be able to do research? Most of our experimental research opportunities involve optics. We have students working on investigations that range from atomic spectroscopy of rubidium to Rayleigh scattering to optical tweezers to quantum optics. When a student starts research, we want them to be ready to go. We don't want them to have to relearn material (or for us to reteach material) that they should already have mastered in earlier classes.

Partial IGF-1 deficiency is sufficient to reduce heart contractibility, angiotensin II sensibility, and alter gene expression of structural and functional cardiac proteins.

PubMed

González-Guerra, José Luis; Castilla-Cortazar, Inma; Aguirre, Gabriel A; Muñoz, Úrsula; Martín-Estal, Irene; Ávila-Gallego, Elena; Granado, Miriam; Puche, Juan E; García-Villalón, Ángel Luis

2017-01-01

Circulating levels of IGF-1 may decrease under several circumstances like ageing, metabolic syndrome, and advanced cirrhosis. This reduction is associated with insulin resistance, dyslipidemia, progression to type 2 diabetes, and increased risk for cardiovascular diseases. However, underlying mechanisms between IGF-1 deficiency and cardiovascular disease remain elusive. The specific aim of the present work was to study whether the partial IGF-1 deficiency influences heart and/or coronary circulation, comparing vasoactive factors before and after of ischemia-reperfusion (I/R). In addition, histology of the heart was performed together with cardiac gene expression for proteins involved in structure and function (extracellular matrix, contractile proteins, active peptides); carried out using microarrays, followed by RT-qPCR confirmation of the three experimental groups. IGF-1 partial deficiency is associated to a reduction in contractility and angiotensin II sensitivity, interstitial fibrosis as well as altered expression pattern of genes involved in extracellular matrix proteins, calcium dynamics, and cardiac structure and function. Although this work is descriptive, it provides a clear insight of the impact that partial IGF-1 deficiency on the heart and establishes this experimental model as suitable for studying cardiac disease mechanisms and exploring therapeutic options for patients under IGF-1 deficiency conditions.

Partial IGF-1 deficiency is sufficient to reduce heart contractibility, angiotensin II sensibility, and alter gene expression of structural and functional cardiac proteins

PubMed Central

Aguirre, Gabriel A.; Muñoz, Úrsula; Martín-Estal, Irene; Ávila-Gallego, Elena; Granado, Miriam; Puche, Juan E.; García-Villalón, Ángel Luis

2017-01-01

Circulating levels of IGF-1 may decrease under several circumstances like ageing, metabolic syndrome, and advanced cirrhosis. This reduction is associated with insulin resistance, dyslipidemia, progression to type 2 diabetes, and increased risk for cardiovascular diseases. However, underlying mechanisms between IGF-1 deficiency and cardiovascular disease remain elusive. The specific aim of the present work was to study whether the partial IGF-1 deficiency influences heart and/or coronary circulation, comparing vasoactive factors before and after of ischemia-reperfusion (I/R). In addition, histology of the heart was performed together with cardiac gene expression for proteins involved in structure and function (extracellular matrix, contractile proteins, active peptides); carried out using microarrays, followed by RT-qPCR confirmation of the three experimental groups. IGF-1 partial deficiency is associated to a reduction in contractility and angiotensin II sensitivity, interstitial fibrosis as well as altered expression pattern of genes involved in extracellular matrix proteins, calcium dynamics, and cardiac structure and function. Although this work is descriptive, it provides a clear insight of the impact that partial IGF-1 deficiency on the heart and establishes this experimental model as suitable for studying cardiac disease mechanisms and exploring therapeutic options for patients under IGF-1 deficiency conditions. PMID:28806738

Measurement and prediction of the thermomechanical response of shape memory alloy hybrid composite beams

NASA Astrophysics Data System (ADS)

Davis, Brian; Turner, Travis L.; Seelecke, Stefan

2005-05-01

Previous work at NASA Langley Research Center (LaRC) involved fabrication and testing of composite beams with embedded, pre-strained shape memory alloy (SMA) ribbons within the beam structures. That study also provided comparison of experimental results with numerical predictions from a research code making use of a new thermoelastic model for shape memory alloy hybrid composite (SMAHC) structures. The previous work showed qualitative validation of the numerical model. However, deficiencies in the experimental-numerical correlation were noted and hypotheses for the discrepancies were given for further investigation. The goal of this work is to refine the experimental measurement and numerical modeling approaches in order to better understand the discrepancies, improve the correlation between prediction and measurement, and provide rigorous quantitative validation of the numerical analysis/design tool. The experimental investigation is refined by a more thorough test procedure and incorporation of higher fidelity measurements such as infrared thermography and projection moire interferometry. The numerical results are produced by a recently commercialized version of the constitutive model as implemented in ABAQUS and are refined by incorporation of additional measured parameters such as geometric imperfection. Thermal buckling, post-buckling, and random responses to thermal and inertial (base acceleration) loads are studied. The results demonstrate the effectiveness of SMAHC structures in controlling static and dynamic responses by adaptive stiffening. Excellent agreement is achieved between the predicted and measured results of the static and dynamic thermomechanical response, thereby providing quantitative validation of the numerical tool.

Measurement and Prediction of the Thermomechanical Response of Shape Memory Alloy Hybrid Composite Beams

NASA Technical Reports Server (NTRS)

Davis, Brian; Turner, Travis L.; Seelecke, Stefan

2005-01-01

Previous work at NASA Langley Research Center (LaRC) involved fabrication and testing of composite beams with embedded, pre-strained shape memory alloy (SMA) ribbons within the beam structures. That study also provided comparison of experimental results with numerical predictions from a research code making use of a new thermoelastic model for shape memory alloy hybrid composite (SMAHC) structures. The previous work showed qualitative validation of the numerical model. However, deficiencies in the experimental-numerical correlation were noted and hypotheses for the discrepancies were given for further investigation. The goal of this work is to refine the experimental measurement and numerical modeling approaches in order to better understand the discrepancies, improve the correlation between prediction and measurement, and provide rigorous quantitative validation of the numerical analysis/design tool. The experimental investigation is refined by a more thorough test procedure and incorporation of higher fidelity measurements such as infrared thermography and projection moire interferometry. The numerical results are produced by a recently commercialized version of the constitutive model as implemented in ABAQUS and are refined by incorporation of additional measured parameters such as geometric imperfection. Thermal buckling, post-buckling, and random responses to thermal and inertial (base acceleration) loads are studied. The results demonstrate the effectiveness of SMAHC structures in controlling static and dynamic responses by adaptive stiffening. Excellent agreement is achieved between the predicted and measured results of the static and dynamic thermomechanical response, thereby providing quantitative validation of the numerical tool.

Genome analysis of the thermoacidophilic archaeon Acidianus copahuensis focusing on the metabolisms associated to biomining activities.

PubMed

Urbieta, María Sofía; Rascovan, Nicolás; Vázquez, Martín P; Donati, Edgardo

2017-06-06

Several archaeal species from the order Sulfolobales are interesting from the biotechnological point of view due to their biomining capacities. Within this group, the genus Acidianus contains four biomining species (from ten known Acidianus species), but none of these have their genome sequenced. To get insights into the genetic potential and metabolic pathways involved in the biomining activity of this group, we sequenced the genome of Acidianus copahuensis ALE1 strain, a novel thermoacidophilic crenarchaeon (optimum growth: 75 °C, pH 3) isolated from the volcanic geothermal area of Copahue at Neuquén province in Argentina. Previous experimental characterization of A. copahuensis revealed a high biomining potential, exhibited as high oxidation activity of sulfur and sulfur compounds, ferrous iron and sulfide minerals (e.g.: pyrite). This strain is also autotrophic and tolerant to heavy metals, thus, it can grow under adverse conditions for most forms of life with a low nutrient demand, conditions that are commonly found in mining environments. In this work we analyzed the genome of Acidianus copahuensis and describe the genetic pathways involved in biomining processes. We identified the enzymes that are most likely involved in growth on sulfur and ferrous iron oxidation as well as those involved in autotrophic carbon fixation. We also found that A. copahuensis genome gathers different features that are only present in particular lineages or species from the order Sulfolobales, some of which are involved in biomining. We found that although most of its genes (81%) were found in at least one other Sulfolobales species, it is not specifically closer to any particular species (60-70% of proteins shared with each of them). Although almost one fifth of A. copahuensis proteins are not found in any other Sulfolobales species, most of them corresponded to hypothetical proteins from uncharacterized metabolisms. In this work we identified the genes responsible for the biomining metabolisms that we have previously observed experimentally. We provide a landscape of the metabolic potentials of this strain in the context of Sulfolobales and propose various pathways and cellular processes not yet fully understood that can use A. copahuensis as an experimental model to further understand the fascinating biology of thermoacidophilic biomining archaea.

Simple analysis of scattering data with the Ornstein-Zernike equation

NASA Astrophysics Data System (ADS)

Kats, E. I.; Muratov, A. R.

2018-01-01

In this paper we propose and explore a method of analysis of the scattering experimental data for uniform liquidlike systems. In our pragmatic approach we are not trying to introduce by hands an artificial small parameter to work out a perturbation theory with respect to the known results, e.g., for hard spheres or sticky hard spheres (all the more that in the agreement with the notorious Landau statement, there is no physical small parameter for liquids). Instead of it being guided by the experimental data we are solving the Ornstein-Zernike equation with a trial (variational) form of the interparticle interaction potential. To find all needed correlation functions this variational input is iterated numerically to satisfy the Ornstein-Zernike equation supplemented by a closure relation. Our method is developed for spherically symmetric scattering objects, and our numeric code is written for such a case. However, it can be extended (at the expense of more involved computations and a larger amount of required experimental input information) for nonspherical particles. What is important for our approach is that it is sufficient to know experimental data in a relatively narrow range of the scattering wave vectors (q ) to compute the static structure factor in a much broader range of q . We illustrate by a few model and real experimental examples of the x-ray and neutron scattering data how the approach works.

Composition of web services using Markov decision processes and dynamic programming.

PubMed

Uc-Cetina, Víctor; Moo-Mena, Francisco; Hernandez-Ucan, Rafael

2015-01-01

We propose a Markov decision process model for solving the Web service composition (WSC) problem. Iterative policy evaluation, value iteration, and policy iteration algorithms are used to experimentally validate our approach, with artificial and real data. The experimental results show the reliability of the model and the methods employed, with policy iteration being the best one in terms of the minimum number of iterations needed to estimate an optimal policy, with the highest Quality of Service attributes. Our experimental work shows how the solution of a WSC problem involving a set of 100,000 individual Web services and where a valid composition requiring the selection of 1,000 services from the available set can be computed in the worst case in less than 200 seconds, using an Intel Core i5 computer with 6 GB RAM. Moreover, a real WSC problem involving only 7 individual Web services requires less than 0.08 seconds, using the same computational power. Finally, a comparison with two popular reinforcement learning algorithms, sarsa and Q-learning, shows that these algorithms require one or two orders of magnitude and more time than policy iteration, iterative policy evaluation, and value iteration to handle WSC problems of the same complexity.

Description of Adsorption in Liquid Chromatography under Nonideal Conditions.

PubMed

Ortner, Franziska; Ruppli, Chantal; Mazzotti, Marco

2018-05-15

A thermodynamically consistent description of binary adsorption in reversed-phase chromatography is presented, accounting for thermodynamic nonidealities in the liquid and adsorbed phases. The investigated system involves the adsorbent Zorbax 300SB-C18, as well as phenetole and 4- tert-butylphenol as solutes and methanol and water as inert components forming the eluent. The description is based on adsorption isotherms, which are a function of the liquid-phase activities, to account for nonidealities in the liquid phase. Liquid-phase activities are calculated with a UNIQUAC model established in this work, based on experimental phase equilibrium data. The binary interaction in the adsorbed phase is described by the adsorbed solution theory, assuming an ideal (ideal adsorbed solution theory) or real (real adsorbed solution theory) adsorbed phase. Implementation of the established adsorption model in a chromatographic code achieves a quantitative description of experimental elution profiles, with feed compositions exploiting the entire miscible region, and involving a broad range of different eluent compositions (methanol/water). The quantitative agreement of the model and experimental data serves as a confirmation of the underlying physical (thermodynamic) concepts and of their applicability to a broad range of operating conditions.

Qualitative novelty in seventeenth-century science: Hydrostatics from Stevin to Pascal.

PubMed

Chalmers, Alan F

2015-06-01

Two works on hydrostatics, by Simon Stevin in 1586 and by Blaise Pascal in 1654, are analysed and compared. The contrast between the two serves to highlight aspects of the qualitative novelty involved in changes within science in the first half of the seventeenth century. Stevin attempted to derive his theory from unproblematic postulates drawn from common sense but failed to achieve his goal insofar as he needed to incorporate assumptions involved in his engineering practice but not sanctioned by his postulates. Pascal's theory went beyond common sense by introducing a novel concept, pressure. Theoretical reflection on novel experiments was involved in the construction of the new concept and experiment also provided important evidence for the theory that deployed it. The new experimental reasoning was qualitatively different from the Euclidean style of reasoning adopted by Stevin. The fact that a conceptualization of a technical sense of pressure adequate for hydrostatics was far from obvious is evident from the work of those, such as Galileo and Descartes, who did not make significant moves in that direction. Copyright © 2015 Elsevier Ltd. All rights reserved.

Enabling CSPA Operations Through Pilot Involvement in Longitudinal Approach Spacing

NASA Technical Reports Server (NTRS)

Battiste, Vernol (Technical Monitor); Pritchett, Amy

2003-01-01

Several major airports around the United States have, or plan to have, closely-spaced parallel runways. This project complemented current and previous research by examining the pilots ability to control their position longitudinally within their approach stream.This project s results considered spacing for separation from potential positions of wake vortices from the parallel approach. This preventive function could enable CSPA operations to very closely spaced runways. This work also considered how pilot involvement in longitudinal spacing could allow for more efficient traffic flow, by allowing pilots to keep their aircraft within tighter arrival slots then air traffic control (ATC) might be able to establish, and by maintaining space within the arrival stream for corresponding departure slots. To this end, this project conducted several research studies providing an analytic and computational basis for calculating appropriate aircraft spacings, experimental results from a piloted flight simulator test, and an experimental testbed for future simulator tests. The following sections summarize the results of these three efforts.

Detailed mechanism for oxidation of benzene

NASA Technical Reports Server (NTRS)

Bittker, David A.

1990-01-01

A detailed mechanism for the oxidation of benzene is presented and used to compute experimentally obtained concentration profiles and ignition delay times over a wide range of equivalence ratio and temperature. The computed results agree qualitatively with all the experimental trends. Quantitative agreement is obtained with several of the composition profiles and for the temperature dependence of the ignition delay times. There are indications, however, that some important reactions are as yet undiscovered in this mechanism. Recent literature expressions have been used for the rate coefficients of most important reactions, except for some involving phenol. The discrepancy between the phenol pyrolysis rate coefficient used in this work and a recent literature expression remains to be explained.

Experimental and theoretical investigation on the molecular structure, spectroscopic and electric properties of 2,4-dinitrodiphenylamine, 2-nitro-4-(trifluoromethyl)aniline and 4-bromo-2-nitroaniline.

PubMed

Hernández-Paredes, Javier; Hernández-Negrete, Ofelia; Carrillo-Torres, Roberto C; Sánchez-Zeferino, Raúl; Duarte-Moller, Alberto; Alvarez-Ramos, Mario E

2015-10-05

2,4-Dinitrodiphenylamine (I), 2-nitro-4-(trifluoromethyl)aniline (II) and 4-bromo-2-nitroaniline (III) have been investigated by DFT and experimental FTIR, Raman and UV-Vis spectroscopies. The gas-phase molecular geometries were consistent with similar compounds already reported in the literature. From the vibrational analysis, the main functional groups were identified and their absorption bands were assigned. Some differences were found between the calculated and the experimental UV-Vis spectra. These differences were analyzed and explained in terms of the TD-DFT/B3LYP limitations, which were mainly attributed to charge-transfer (CT) effects. These findings were in agreement with previous works, which reported that TD-DFT/B3LYP calculations diverge from experimental results when the electronic transitions involve CT. Despite this, TD-DFT/B3LYP calculations provided satisfactory results and a detailed description of the electronic transitions involved in the absorption bands of the UV-Vis spectra. In terms of the NLO properties, it was found that compound (I) is a good candidate for NLO applications and deserves further study due to its good β values. However, the β values for compounds (II) and (III) were negatively affected compared to those found on o-nitroaniline. Copyright © 2015 Elsevier B.V. All rights reserved.

Measuring the coefficient of restitution and more: a simple experiment to promote students’ critical thinking and autonomous work

NASA Astrophysics Data System (ADS)

González, Manuel Á.; González, Miguel Á.; Vegas, Jesús; Llamas, César

2017-09-01

A simple experiment on the determination of the coefficient of restitution of different materials is taken as the basis of an extendable work that can be done by students in an autonomous way. On the whole, the work described in this paper would involve concepts of kinematics, materials science, air drag and buoyancy, and would help students to think of physics as a whole subject instead of a set of, more or less, isolated parts. The experiment can be done either in teaching laboratories or as an autonomous work by students at home. Students’ smartphones and cheap balls of different materials are the only experimental materials required to do the experiment. The proposed work also permits the students to analyse the limitations of a physical model used in the experiment by analysing the approximations considered in it, and then enhancing their critical thinking.

16 CFR 1702.10 - Human experimental data involving the testing of human subjects.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 16 Commercial Practices 2 2011-01-01 2011-01-01 false Human experimental data involving the testing of human subjects. 1702.10 Section 1702.10 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION... PACKAGING ACT REQUIREMENTS; PETITION PROCEDURES AND REQUIREMENTS § 1702.10 Human experimental data involving...

16 CFR 1702.10 - Human experimental data involving the testing of human subjects.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 16 Commercial Practices 2 2012-01-01 2012-01-01 false Human experimental data involving the testing of human subjects. 1702.10 Section 1702.10 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION... PACKAGING ACT REQUIREMENTS; PETITION PROCEDURES AND REQUIREMENTS § 1702.10 Human experimental data involving...

16 CFR 1702.10 - Human experimental data involving the testing of human subjects.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 16 Commercial Practices 2 2014-01-01 2014-01-01 false Human experimental data involving the testing of human subjects. 1702.10 Section 1702.10 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION... PACKAGING ACT REQUIREMENTS; PETITION PROCEDURES AND REQUIREMENTS § 1702.10 Human experimental data involving...

16 CFR 1702.10 - Human experimental data involving the testing of human subjects.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 16 Commercial Practices 2 2010-01-01 2010-01-01 false Human experimental data involving the testing of human subjects. 1702.10 Section 1702.10 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION... PACKAGING ACT REQUIREMENTS; PETITION PROCEDURES AND REQUIREMENTS § 1702.10 Human experimental data involving...

Final Report of DOE Grant No. DE-FG02-04ER41306

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nandi, Satyanarayan; Babu, Kaladi S; Rizatdinova, Flera

2013-12-10

Project: Theoretical and Experimental Research in Weak, Electromagnetic and Strong Interactions: Investigators: S. Nandi, K.S. Babu, F. Rizatdinova Institution: Oklahoma State University, Stillwater, OK 74078 This completed project focused on the cutting edge research in theoretical and experimental high energy physics. In theoretical high energy physics, the two investigators (Nandi and Babu) worked on a variety of topics in model-building and phenomenological aspects of elementary particle physics. This includes unification of particles and forces, neutrino physics, Higgs boson physics, proton decay, supersymmetry, and collider physics. Novel physics ideas beyond the Standard Model with testable consequences at the LHC have beenmore » proposed. These ideas have stimulated the experimental community to look for new signals. The contributions of the experimental high energy physics group has been at the D0 experiment at the Fermilab Tevatraon and the ATLAS experiment at the Large Hadron Collider. At the D0 experiment, the main focus was search for the Higgs boson in the WH channel, where improved limits were obtained. At the LHC, the OSU group has made significant contributions to the top quark physics, and the calibration of the b-tagging algorithms. The group is also involved in the pixel detector upgrade. This DOE supported grant has resulted in 5 PhD degrees during the past three years. Three postdoctoral fellows were supported as well. In theoretical research over 40 refereed publications have resulted in the past three years, with several involving graduate students and postdoctoral fellows. It also resulted in over 30 conference presentations in the same time period. We are also involved in outreach activities through the Quarknet program, where we engage Oklahoma school teachers and students in our research.« less

The combined fatigue effects of sequential exposure to seated whole body vibration and physical, mental, or concurrent work demands

PubMed Central

Lang, Angelica E.; Stobart, Jamie; Kociolek, Aaron M.; Milosavljevic, Stephan; Trask, Catherine

2017-01-01

Many occupations in agriculture, construction, transportation, and forestry are non-routine, involving non-cyclical tasks, both discretionary and non-discretionary work breaks, and a mix of work activities. Workers in these industries are exposed to seated whole body vibration (WBV) and tasks consisting of physical, mental, or a combination of demands. Risk assessment tools for non-routinized jobs have emerged but there remains a need to understand the combined effects of different work demands to improve risk assessment methods and ultimately inform ergonomists and workers on optimum work arrangement and scheduling strategies. The objective of this study was to investigate fatigue-related human responses of WBV sequentially combined with physical, mental, or concurrent physical and mental demands. Sixteen healthy participants performed four conditions on four separate days: (1) physically demanding work, (2) mentally demanding work, (3) concurrent work, and (4) control quiet sitting. For each condition, participants performed two 15-minute bouts of the experimental task, separated by 30-minutes of simulated WBV based on realistic all-terrain vehicle (ATV) riding data. A test battery of fatigue measures consisting of biomechanical, physiological, cognitive, and sensorimotor measurements were collected at four interval periods: pre-session, after the first bout of the experimental task and before WBV, after WBV and before the second bout of the experimental task, and post-session. Nine measures demonstrated statistically significant time effects during the control condition; 11, 7, and 12 measures were significant in the physical, mental, and concurrent conditions, respectively. Overall, the effects of seated WBV in combination with different tasks are not additive but possibly synergistic or antagonistic. There appears to be a beneficial effect of seated ATV operation as a means of increasing task variation; but since excessive WBV may independently pose a health risk in the longer-term, these beneficial results may not be sensible as a long-term solution. PMID:29236752

The combined fatigue effects of sequential exposure to seated whole body vibration and physical, mental, or concurrent work demands.

PubMed

Yung, Marcus; Lang, Angelica E; Stobart, Jamie; Kociolek, Aaron M; Milosavljevic, Stephan; Trask, Catherine

2017-01-01

Many occupations in agriculture, construction, transportation, and forestry are non-routine, involving non-cyclical tasks, both discretionary and non-discretionary work breaks, and a mix of work activities. Workers in these industries are exposed to seated whole body vibration (WBV) and tasks consisting of physical, mental, or a combination of demands. Risk assessment tools for non-routinized jobs have emerged but there remains a need to understand the combined effects of different work demands to improve risk assessment methods and ultimately inform ergonomists and workers on optimum work arrangement and scheduling strategies. The objective of this study was to investigate fatigue-related human responses of WBV sequentially combined with physical, mental, or concurrent physical and mental demands. Sixteen healthy participants performed four conditions on four separate days: (1) physically demanding work, (2) mentally demanding work, (3) concurrent work, and (4) control quiet sitting. For each condition, participants performed two 15-minute bouts of the experimental task, separated by 30-minutes of simulated WBV based on realistic all-terrain vehicle (ATV) riding data. A test battery of fatigue measures consisting of biomechanical, physiological, cognitive, and sensorimotor measurements were collected at four interval periods: pre-session, after the first bout of the experimental task and before WBV, after WBV and before the second bout of the experimental task, and post-session. Nine measures demonstrated statistically significant time effects during the control condition; 11, 7, and 12 measures were significant in the physical, mental, and concurrent conditions, respectively. Overall, the effects of seated WBV in combination with different tasks are not additive but possibly synergistic or antagonistic. There appears to be a beneficial effect of seated ATV operation as a means of increasing task variation; but since excessive WBV may independently pose a health risk in the longer-term, these beneficial results may not be sensible as a long-term solution.

Temperature and number density measurements using Raman scattering in turbulent-supersonic-combusting flows

NASA Astrophysics Data System (ADS)

Jeyashekar, Nigil Satish

Scramjet engines propelled at hypersonic velocities have the potential to replace existing rocket launchers. Commercializing the vehicle is an arduous task, owing to issues relating to low combustion efficiency. The performance, thrust, and speed of the engine can be improved by optimizing: turbulence-chemistry interaction to provide mixing conditions favorable for the chemistry, pressure buildup, and re-circulation of hydrogen throughout the engine. The performance of the engine can be measured, flow and chemical dynamics can be evaluated when all three variables in the transport equations are known. The variables are instantaneous flow velocity, static temperature (refers to the macroscopic temperature and not the molecular species temperature), and total number density at a point in the flow. The motive is to build a non-intrusive tool to measure thermodynamic quantities (static temperature and total number density). This can be integrated with a velocity measurement tool, in the future, to obtain all three variables simultaneously and instantaneously. The dissertation describes in detail the motivation for the proposed work, with introduction to the formalism involved, with a concise literature review, followed by mathematical perspective to obtain the working equations for temperature and number density. The design of the adiabatic burner and the experimental setup used for calibration is discussed with the uncertainty involved in measurements. The measurements are made for a certain set of flow conditions in the laminar burner by Raman scattering and is validated by comparing it to the theoretical/adiabatic flame temperature and mole fraction plots, in lean and rich regime. This technique is applied to turbulent, supersonic, hydrogen-air flame of an afterburning rocket nozzle. The statistics of temperature and total number density versus the corresponding values at adiabatic conditions gives the departure from thermal and chemical equilibrium. The extent of mixing and combustion can be concluded from such statistics. The future work will involve experimental modifications to make line and planar measurements in combusting jets.

Fault lubrication during earthquakes.

PubMed

Di Toro, G; Han, R; Hirose, T; De Paola, N; Nielsen, S; Mizoguchi, K; Ferri, F; Cocco, M; Shimamoto, T

2011-03-24

The determination of rock friction at seismic slip rates (about 1 m s(-1)) is of paramount importance in earthquake mechanics, as fault friction controls the stress drop, the mechanical work and the frictional heat generated during slip. Given the difficulty in determining friction by seismological methods, elucidating constraints are derived from experimental studies. Here we review a large set of published and unpublished experiments (∼300) performed in rotary shear apparatus at slip rates of 0.1-2.6 m s(-1). The experiments indicate a significant decrease in friction (of up to one order of magnitude), which we term fault lubrication, both for cohesive (silicate-built, quartz-built and carbonate-built) rocks and non-cohesive rocks (clay-rich, anhydrite, gypsum and dolomite gouges) typical of crustal seismogenic sources. The available mechanical work and the associated temperature rise in the slipping zone trigger a number of physicochemical processes (gelification, decarbonation and dehydration reactions, melting and so on) whose products are responsible for fault lubrication. The similarity between (1) experimental and natural fault products and (2) mechanical work measures resulting from these laboratory experiments and seismological estimates suggests that it is reasonable to extrapolate experimental data to conditions typical of earthquake nucleation depths (7-15 km). It seems that faults are lubricated during earthquakes, irrespective of the fault rock composition and of the specific weakening mechanism involved.

Developing students’ learning achievement and experimental skills on buoyancy and the involvement of Newton’s third law through experimental sets

NASA Astrophysics Data System (ADS)

Chokchai, Jaewijarn; Khanti, Toedtanya; Sura, Wuttiprom

2017-09-01

The purposes of this research were: to construct packages of operations on buoyancy and the involvement of Newton’s third law, to enhance achievement score of students on buoyancy and the involvement of Newton’s third law, to enhance experimental skills on buoyancy and the involvement of Newton’s third law and to evaluate students’ attitude towards the packages of operations on buoyancy and the involvement of Newton’s third law using inquiry method. The samples were 42 grade 11 students in academic year 2016 at Hatyaiwittayalai School, Hatyai, Songkhla. The research method was one group pretest-posttest design. The research tools consisted of experimental set on buoyancy and the involvement of Newton’s third law, the learning achievement test on buoyancy and the involvement of Newton’s third law and the students’ attitude questionnaires. The experimental skills of most students was in a good level . The satisfaction of most students was in a good level. The research showed the learning achievement after instruction higher than that before instruction using experimental set at the significant level of 0.05 and the class average normalized gain is in the medium gain

Education on electrical phenomena involved in electroporation-based therapies and treatments: a blended learning approach.

PubMed

Čorović, Selma; Mahnič-Kalamiza, Samo; Miklavčič, Damijan

2016-04-07

Electroporation-based applications require multidisciplinary expertise and collaboration of experts with different professional backgrounds in engineering and science. Beginning in 2003, an international scientific workshop and postgraduate course electroporation based technologies and treatments (EBTT) has been organized at the University of Ljubljana to facilitate transfer of knowledge from leading experts to researches, students and newcomers in the field of electroporation. In this paper we present one of the integral parts of EBTT: an e-learning practical work we developed to complement delivery of knowledge via lectures and laboratory work, thus providing a blended learning approach on electrical phenomena involved in electroporation-based therapies and treatments. The learning effect was assessed via a pre- and post e-learning examination test composed of 10 multiple choice questions (i.e. items). The e-learning practical work session and both of the e-learning examination tests were carried out after the live EBTT lectures and other laboratory work. Statistical analysis was performed to compare and evaluate the learning effect measured in two groups of students: (1) electrical engineers and (2) natural scientists (i.e. medical doctors, biologists and chemists) undergoing the e-learning practical work in 2011-2014 academic years. Item analysis was performed to assess the difficulty of each item of the examination test. The results of our study show that the total score on the post examination test significantly improved and the item difficulty in both experimental groups decreased. The natural scientists reached the same level of knowledge (no statistical difference in total post-examination test score) on the post-course test take, as do electrical engineers, although the engineers started with statistically higher total pre-test examination score, as expected. The main objective of this study was to investigate whether the educational content the e-learning practical work presented to the students with different professional backgrounds enhanced their knowledge acquired via lectures during EBTT. We compared the learning effect assessed in two experimental groups undergoing the e-learning practical work: electrical engineers and natural scientists. The same level of knowledge on the post-course examination was reached in both groups. The results indicate that our e-learning platform supported by blended learning approach provides an effective learning tool for populations with mixed professional backgrounds and thus plays an important role in bridging the gap between scientific domains involved in electroporation-based technologies and treatments.

Armored Enzyme Nanoparticles for Remediation of Subsurface Contaminants

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jonathan S. Dordick; Jay Grate; Jungbae Kim

2007-02-19

The remediation of subsurface contaminants is a critical problem for the Department of Energy, other government agencies, and our nation. Severe contamination of soil and groundwater exists at several DOE sites due to various methods of intentional and unintentional release. Given the difficulties involved in conventional removal or separation processes, it is vital to develop methods to transform contaminants and contaminated earth/water to reduce risks to human health and the environment. Transformation of the contaminants themselves may involve conversion to other immobile species that do not migrate into well water or surface waters, as is proposed for metals and radionuclides;more » or degradation to harmless molecules, as is desired for organic contaminants. Transformation of contaminated earth (as opposed to the contaminants themselves) may entail reductions in volume or release of bound contaminants for remediation. Research at Rensselaer focused on the development of haloalkane dehalogenase as a critical enzyme in the dehalogenation of contaminated materials (ultimately trichloroethylene and related pollutants). A combination of bioinformatic investigation and experimental work was performed. The bioinformatics was focused on identifying a range of dehalogenase enzymes that could be obtained from the known proteomes of major microorganisms. This work identified several candidate enzymes that could be obtained through relatively straightforward gene cloning and expression approaches. The experimental work focused on the isolation of haloalkane dehalogenase from a Xanthobacter species followed by incorporating the enzyme into silicates to form biocatalytic silicates. These are the precursors of SENs. At the conclusion of the study, dehalogenase was incorporated into SENs, although the loading was low. This work supported a single Ph.D. student (Ms. Philippa Reeder) for two years. The project ended prior to her being able to perform substantive bioinformatics efforts that would identify more promising dehalogenase enzymes. The SEN synthesis, however, was demonstrated to be partially successful with dehalogenases. Further work would provide optimized dehalogenases in SENs for use in pollution remission.« less

July 1999 working group meeting on heavy vehicle aerodynamic drag: presentations and summary of comments and conclusions

DOE Office of Scientific and Technical Information (OSTI.GOV)

Brady, M; Browand, F; Flowers, D

A Working Group Meeting on Heavy Vehicle Aerodynamic Drag was held at University of Southern California, Los Angeles, California on July 30, 1999. The purpose of the meeting was to present technical details on the experimental and computational plans and approaches and provide an update on progress in obtaining experimental results, model developments, and simulations. The focus of the meeting was a review of University of Southern California's (USC) experimental plans and results and the computational results from Lawrence Livermore National Laboratory (LLNL) and Sandia National Laboratories (SNL) for the integrated tractor-trailer benchmark geometry called the Sandia Model. Much ofmore » the meeting discussion involved the NASA Ames 7 ft x 10 ft wind tunnel tests and the need for documentation of the results. The present and projected budget and funding situation was also discussed. Presentations were given by representatives from the Department of Energy (DOE) Office of Transportation Technology Office of Heavy Vehicle Technology (OHVT), LLNL, SNL, USC, and California Institute of Technology (Caltech). This report contains the technical presentations (viewgraphs) delivered at the Meeting, briefly summarizes the comments and conclusions, and outlines the future action items.« less

Scale model experimentation: using terahertz pulses to study light scattering.

PubMed

Pearce, Jeremy; Mittleman, Daniel M

2002-11-07

We describe a new class of experiments involving applications of terahertz radiation to problems in biomedical imaging and diagnosis. These involve scale model measurements, in which information can be gained about pulse propagation in scattering media. Because of the scale invariance of Maxwell's equations, these experiments can provide insight for researchers working on similar problems at shorter wavelengths. As a first demonstration, we measure the propagation constants for pulses in a dense collection of spherical scatterers, and compare with the predictions of the quasi-crystalline approximation. Even though the fractional volume in our measurements exceeds the limit of validity of this model, we find that it still predicts certain features of the propagation with reasonable accuracy.

Analysis of eroded bovine teeth through laser speckle imaging

NASA Astrophysics Data System (ADS)

Koshoji, Nelson H.; Bussadori, Sandra K.; Bortoletto, Carolina C.; Oliveira, Marcelo T.; Prates, Renato A.; Deana, Alessandro M.

2015-02-01

Dental erosion is a non-carious lesion that causes progressive tooth wear of structure through chemical processes that do not involve bacterial action. Its origin is related to eating habits or systemic diseases involving tooth contact with substances that pose a very low pH. This work demonstrates a new methodology to quantify the erosion by coherent light scattering of tooth surface. This technique shows a correlation between acid etch duration and laser speckle contrast map (LASCA). The experimental groups presented a relative contrast between eroded and sound tissue of 17.8(45)%, 23.4 (68)% 39.2 (40)% and 44.3 (30)%, for 10 min, 20 min, 30 min and 40 min of acid etching, respectively.

Preventing Substance Abuse among Black and Hispanic Adolescent Girls: Results from a Computer-Delivered, Mother-Daughter Intervention Approach

PubMed Central

Schinke, Steven P.; Fang, Lin; Cole, Kristin C. A.

2010-01-01

This 2008 study involved 546 Black- and Hispanic-American adolescent girls and their mothers from New York, New Jersey, and Connecticut. Participants provided self-report data. Analysis of covariance indicated that the experimental intervention reduced risk factors, improved protective factors, and lowered girls' alcohol use and their future intentions to use substances. The study supports the value of computer-based and gender-specific interventions that involve girls and mothers. Future work needs to replicate and strengthen study results. Research support came from the National Institute on Drug Abuse within the National Institutes of Health of the United States Public Health Service. PMID:21190404

Genesis of Prolactinomas: Studies Using Estrogen-Treated Animals

PubMed Central

Sarkar, Dipak K.

2010-01-01

Prolactin-secreting adenomas (prolactinomas) are the most prevalent form of pituitary tumors in humans. Our knowledge of the formation of these tumors is limited. Experimental work in animal has uncovered that estradiol exposure leads to prolactinoma formation via orchestrated events involving dopamine D2 receptors, transforming growth factor-β (TGF-β) isoforms and their receptors, as well as factors secondary to TGF-β action. Additionally, these studies determined that TGF-β and b-FGF interact to facilitate the communication between lactotropes and folliculo-stellate cells that is necessary for the mitogenic action of estradiol. The downstream signaling that governs lactotropic cell proliferation involves activation of the MAP kinase p44/42-dependent pathway. PMID:16809921

MHD processes in the outer heliosphere

NASA Technical Reports Server (NTRS)

Burlaga, L. F.

1984-01-01

The magnetic field measurements from Voyager and the magnetohydrodynamic (MHD) processes in the outer heliosphere are reviewed. A bibliography of the experimental and theoretical work concerning magnetic fields and plasmas observed in the outer heliosphere is given. Emphasis in this review is on basic concepts and dynamical processes involving the magnetic field. The theory that serves to explain and unify the interplanetary magnetic field and plasma observations is magnetohydrodynamics. Basic physical processes and observations that relate directly to solutions of the MHD equations are emphasized, but obtaining solutions of this complex system of equations involves various assumptions and approximations. The spatial and temporal complexity of the outer heliosphere and some approaches for dealing with this complexity are discussed.

Simulation of the photodetachment spectrum of HHfO- using coupled-cluster calculations

NASA Astrophysics Data System (ADS)

Mok, Daniel K. W.; Dyke, John M.; Lee, Edmond P. F.

2016-12-01

The photodetachment spectrum of HHfO- was simulated using restricted-spin coupled-cluster single-double plus perturbative triple {RCCSD(T)} calculations performed on the ground electronic states of HHfO and HHfO-, employing basis sets of up to quintuple-zeta quality. The computed RCCSD(T) electron affinity of 1.67 ± 0.02 eV at the complete basis set limit, including Hf 5s25p6 core correlation and zero-point energy corrections, agrees well with the experimental value of 1.70 ± 0.05 eV from a recent photodetachment study [X. Li et al., J. Chem. Phys. 136, 154306 (2012)]. For the simulation, Franck-Condon factors were computed which included allowances for anharmonicity and Duschinsky rotation. Comparisons between simulated and experimental spectra confirm the assignments of the molecular carrier and electronic states involved but suggest that the experimental vibrational structure has suffered from poor signal-to-noise ratio. An alternative assignment of the vibrational structure to that suggested in the experimental work is presented.

Effect of Temperature on the Storage Life of Polysulfide Sealants

DTIC Science & Technology

1989-01-01

University of Adelaide, South Australia. After two and a half years of experience in Rubber Technology with the Olympic Tyre and Rubber Company, Melbourne...he joined the rubber section of MRL in November 1970. Since 1975 he has been involved in R & D work in the sealant section as an Experimental Officer...repeatedly passing the mixture through a triple roll mill. One set of the calcium carbonate-solvent series was enclosed in a heat sealed wrapping of

[Effect of various anions on the rate of microbe-induced corrosion].

PubMed

Piliashenko-Novokhatnyĭ, A I; Asaulenko, L G

2002-01-01

Experimental corroboration of correctness of theoretical thermodynamic calculations of e.m.f. of corrosion reactions induced by soil microorganisms is obtained in the work. A hypothesis is put forward on possible mechanism for stimulation of microbe-induced corrosion by chloride ions. The results obtained permit revealing the reasons of low efficiency conditions of cathode protection in cases of active involvement of soil microorganisms into corrosion processes which are used for maintenance of underground constructions.

Microgravity

NASA Image and Video Library

2004-04-15

The M512 Materials Processing Facility (MPF) with the M518 Multipurpose Electric Facility (MEF) tested and demonstrated a facility approach for materials process experimentation in space. It also provided a basic apparatus and a common interface for a group of metallic and nonmetallic materials experiments. The MPF consisted of a vacuum work chamber and associated mechanical and electrical controls. The M518 Multipurpose Electric Furnace (MEF) was an electric furnace system in which solidification, crystal growth, and other experiments involving phase changes were performed.

Delivering Integrated Care to the Frail Elderly: The Impact on Professionals’ Objective Burden and Job Satisfaction

PubMed Central

Huijsman, Robbert; de Kuyper, Ruben Dennis Maurice; Fabbricotti, Isabelle Natalina

2016-01-01

Background: The impact of integrated working on professionals’ objective burden and job satisfaction was examined. An evidence-based intervention targeting frail elderly patients was implemented in the Walcheren region of the Netherlands in 2010. The intervention involved the primary care practice as a single entry point, and included proactive frailty screening, a comprehensive assessment of patient needs, case management, multidisciplinary teams, care plans and protocols, task delegation and task specialisation, a shared information system, a geriatric care network and integrated funding. Methods: A quasi-experimental design with a control group was used. Data regarding objective burden involved the professionals’ time investments over a 12-month period that were collected from patient medical records (n = 377) time registrations, transcripts of meetings and patient questionnaires. Data regarding job satisfaction were collected using questionnaires that were distributed to primary care and home-care professionals (n = 180) after the intervention’s implementation. Within- and between-groups comparisons and regression analyses were performed. Results: Non-patient related time was significantly higher in the experimental group than in the control group, whereas patient-related time did not differ. Job satisfaction remained unaffected by the intervention. Conclusion and Discussion: Integrated working is likely to increase objective burden as it requires professionals to perform additional activities that are largely unrelated to actual patient care. Implications for research and practice are discussed. [Current Controlled Trials ISRCTN05748494]. PMID:28413364

Electrocatalytic Mechanism Involving Michaelis-Menten Kinetics at the Preparative Scale: Theory and Applicability to Photocurrents from a Photosynthetic Algae Suspension With Quinones.

PubMed

Longatte, Guillaume; Guille-Collignon, Manon; Lemaître, Frédéric

2017-10-06

In the past years, many strategies have been implemented to benefit from oxygenic photosynthesis to harvest photosynthetic electrons and produce a significant photocurrent. Therefore, electrochemical tools were considered and have globally relied on the electron transfer(s) between the photosynthetic chain and a collecting electrode. In this context, we recently reported the implementation of an electrochemical set-up at the preparative scale to produce photocurrents from a Chlamydomonas reinhardtii algae suspension with an appropriate mediator (2,6-DCBQ) and a carbon gauze as the working electrode. In the present work, we wish to describe a mathematical modeling of the recorded photocurrents to better understand the effects of the experimental conditions on the photosynthetic extraction of electrons. In that way, we established a general model of an electrocatalytic mechanism at the preparative scale (that is, assuming a homogenous bulk solution at any time and a constant diffusion layer, both assumptions being valid under forced convection) in which the chemical step involves a Michaelis-Menten-like behaviour. Dependences of transient and steady-state corresponding currents were analysed as a function of different parameters by means of zone diagrams. This model was tested to our experimental data related to photosynthesis. The corresponding results suggest that competitive pathways beyond photosynthetic harvesting alone should be taken into account. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Characterization of Bond Strength of U-Mo Fuel Plates Using the Laser Shockwave Technique: Capabilities and Preliminary Results

DOE Office of Scientific and Technical Information (OSTI.GOV)

J. A. Smith; D. L. Cottle; B. H. Rabin

2013-09-01

This report summarizes work conducted to-date on the implementation of new laser-based capabilities for characterization of bond strength in nuclear fuel plates, and presents preliminary results obtained from fresh fuel studies on as-fabricated monolithic fuel consisting of uranium-10 wt.% molybdenum alloys clad in 6061 aluminum by hot isostatic pressing. Characterization involves application of two complementary experimental methods, laser-shock testing and laser-ultrasonic imaging, collectively referred to as the Laser Shockwave Technique (LST), that allows the integrity, physical properties and interfacial bond strength in fuel plates to be evaluated. Example characterization results are provided, including measurement of layer thicknesses, elastic properties ofmore » the constituents, and the location and nature of generated debonds (including kissing bonds). LST provides spatially localized, non-contacting measurements with minimum specimen preparation, and is ideally suited for applications involving radioactive materials, including irradiated materials. The theoretical principles and experimental approaches employed in characterizing nuclear fuel plates are described, and preliminary bond strength measurement results are discussed, with emphasis on demonstrating the capabilities and limitations of these methods. These preliminary results demonstrate the ability to distinguish bond strength variations between different fuel plates. Although additional development work is necessary to validate and qualify the test methods, these results suggest LST is viable as a method to meet fuel qualification requirements to demonstrate acceptable bonding integrity.« less

Understanding Scientific Methodology in the Historical and Experimental Sciences via Language Analysis

NASA Astrophysics Data System (ADS)

Dodick, Jeff; Argamon, Shlomo; Chase, Paul

2009-08-01

A key focus of current science education reforms involves developing inquiry-based learning materials. However, without an understanding of how working scientists actually do science, such learning materials cannot be properly developed. Until now, research on scientific reasoning has focused on cognitive studies of individual scientific fields. However, the question remains as to whether scientists in different fields fundamentally rely on different methodologies. Although many philosophers and historians of science do indeed assert that there is no single monolithic scientific method, this has never been tested empirically. We therefore approach this problem by analyzing patterns of language used by scientists in their published work. Our results demonstrate systematic variation in language use between types of science that are thought to differ in their characteristic methodologies. The features of language use that were found correspond closely to a proposed distinction between Experimental Sciences (e.g., chemistry) and Historical Sciences (e.g., paleontology); thus, different underlying rhetorical and conceptual mechanisms likely operate for scientific reasoning and communication in different contexts.

A DSMC Study of Low Pressure Argon Discharge

NASA Astrophysics Data System (ADS)

Hash, David; Meyyappan, M.

1997-10-01

Work toward a self-consistent plasma simulation using the DSMC method for examination of the flowfields of low-pressure high density plasma reactors is presented. Presently, DSMC simulations for these applications involve either treating the electrons as a fluid or imposing experimentally determined values for the electron number density profile. In either approach, the electrons themselves are not physically simulated. Self-consistent plasma DSMC simulations have been conducted for aerospace applications but at a severe computational cost due in part to the scalar architectures on which the codes were employed. The present work attempts to conduct such simulations at a more reasonable cost using a plasma version of the object-oriented parallel Cornell DSMC code, MONACO, on an IBM SP-2. Due the availability of experimental data, the GEC reference cell is chosen to conduct preliminary investigations. An argon discharge is examined thus affording a simple chemistry set with eight gas-phase reactions and five species: Ar, Ar^+, Ar^*, Ar_2, and e where Ar^* is a metastable.

Ignition and combustion characteristics of metallized propellants

NASA Technical Reports Server (NTRS)

Mueller, D. C.; Turns, Stephen R.

1991-01-01

Over the past six months, experimental investigations were continued and theoretical work on the secondary atomization process was begun. Final shakedown of the sizing/velocity measuring system was completed and the aluminum combustion detection system was modified and tested. Atomizer operation was improved to allow steady state operation over long periods of time for several slurries. To validate the theoretical modeling, work involving carbon slurry atomization and combustion was begun and qualitative observations were made. Simultaneous measurements of aluminum slurry droplet size distributions and detection of burning aluminum particles were performed at several axial locations above the burner. The principle theoretical effort was the application of a rigid shell formation model to aluminum slurries and an investigation of the effects of various parameters on the shell formation process. This shell formation model was extended to include the process leading up to droplet disruption, and previously developed analytical models were applied to yield theoretical aluminum agglomerate ignition and combustion times. The several theoretical times were compared with the experimental results.

Stability Limits and Dynamics of Nonaxisymmetric Liquid Bridges

NASA Technical Reports Server (NTRS)

Alexander, J. Iwan D.; Slobozhanin, Lev A.; Resnick, Andrew H.; Ramus, Jean-Francois; Delafontaine, Sylvie

1999-01-01

Liquid bridges have been the focus of numerous theoretical and experimental investigations since the early work by Plateau more than a century ago. More recently, motivated by interest in their physical behavior and their occurrence in a variety of technological situations, there has been a resurgence of interest in the static and dynamic behavior of liquid bridges. Furthermore, opportunities to carry out experiments in the near weightless environment of a low-Earth-orbit spacecraft have also led to a number of low-gravity experiments involving large liquid bridges. In this paper, we present selected results from our work concerning the stability of nonaxisymmetric liquid bridges, the bifurcation of weightless bridges in the neighborhood of the maximum volume stability limit, isorotating axisymmetric bridges contained between equidimensional disks, and bridges contained between unequal disks. For the latter, we discuss both theoretical and experimental results. Finally, we present results concerning the stability of axisymmetric equilibrium configurations for a capillary liquid partly contained in a closed circular cylinder.

Electronic materials high-T(sub c) superconductivity polymers and composites structural materials surface science and catalysts industry participation

NASA Technical Reports Server (NTRS)

1988-01-01

The fifth year of the Center for Advanced Materials was marked primarily by the significant scientific accomplishments of the research programs. The Electronics Materials program continued its work on the growth and characterization of gallium arsenide crystals, and the development of theories to understand the nature and distribution of defects in the crystals. The High Tc Superconductivity Program continued to make significant contributions to the field in theoretical and experimental work on both bulk materials and thin films and devices. The Ceramic Processing group developed a new technique for cladding YBCO superconductors for high current applications in work with the Electric Power Research Institute. The Polymers and Composites program published a number of important studies involving atomistic simulations of polymer surfaces with excellent correlations to experimental results. The new Enzymatic Synthesis of Materials project produced its first fluorinated polymers and successfully began engineering enzymes designed for materials synthesis. The structural Materials Program continued work on novel alloys, development of processing methods for advanced ceramics, and characterization of mechanical properties of these materials, including the newly documented characterization of cyclic fatigue crack propagation behavior in toughened ceramics. Finally, the Surface Science and Catalysis program made significant contributions to the understanding of microporous catalysts and the nature of surface structures and interface compounds.

Characterization of the ELIMED prototype permanent magnet quadrupole system

NASA Astrophysics Data System (ADS)

Russo, A. D.; Schillaci, F.; Pommarel, L.; Romano, F.; Amato, A.; Amico, A. G.; Calanna, A.; Cirrone, G. A. P.; Costa, M.; Cuttone, G.; Amato, C.; De Luca, G.; Flacco, F. A.; Gallo, G.; Giove, D.; Grmek, A.; La Rosa, G.; Leanza, R.; Maggiore, M.; Malka, V.; Milluzzo, G.; Petringa, G.; Pipek, J.; Scuderi, V.; Vauzour, B.; Zappalà, E.

2017-01-01

The system described in this work is meant to be a prototype of a more performing one that will be installed at ELI-Beamlines in Prague for the collection of ions produced after the interaction Laser-target, [1]. It has been realized by the researchers of INFN-LNS (Laboratori Nazionali del Sud of the Instituto Nazionale di Fisica Nucleare) and SIGMAPHI, a French company, using a system of Permanent Magnet Quadrupoles (PMQs), [2]. The final system that will be installed in Prague is designed for protons and carbons up to 60 MeV/u, around 10 times more than the energies involved in the present work. The prototype, shown in this work, has been tested in collaboration with the SAPHIR experimental facility group at LOA (Laboratoire d'Optique Appliqueé) in Paris using a 200 TW Ti:Sapphire laser system. The purpose of this work is to validate the design and the performances of this large and compact bore system and to characterize the beam produced after the interaction laser-target and its features. Moreover, the optics simulations have been compared with a real beam shape on a GAFChromic film. The procedure used during the experimental campaign and the most relevant results are reported here demonstrating a good agreement with the simulations and a good control on the beam optics.

Thermal conductivity improvement in carbon nanoparticle doped PAO oil: An experimental study

NASA Astrophysics Data System (ADS)

Shaikh, S.; Lafdi, K.; Ponnappan, R.

2007-03-01

The present work involves a study on the thermal conductivity of nanoparticle-oil suspensions for three types of nanoparticles, namely, carbon nanotubes (CNTs), exfoliated graphite (EXG), and heat treated nanofibers (HTT) with PAO oil as the base fluid. To accomplish the above task, an experimental analysis is performed using a modern light flash technique (LFA 447) for measuring the thermal conductivity of the three types of nanofluids, for different loading of nanoparticles. The experimental results show a similar trend as observed in literature for nanofluids with a maximum enhancement of approximately 161% obtained for the CNT-PAO oil suspension. The overall percent enhancements for different volume fractions of the nanoparticles are highest for the CNT-based nanofluid, followed by the EXG and the HTT. The findings from this study for the three different types of carbon nanoparticles can have great potential in the field of thermal management.

Metal Nanoparticle Catalysts for Carbon Nanotube Growth

NASA Technical Reports Server (NTRS)

Pierce, Benjamin F.

2003-01-01

Work this summer involved and new and unique process for producing the metal nanoparticle catalysts needed for carbon nanotube (CNT) growth. There are many applications attributed to CNT's, and their properties have deemed them to be a hot spot in research today. Many groups have demonstrated the versatility in CNT's by exploring a wide spectrum of roles that these nanotubes are able to fill. A short list of such promising applications are: nanoscaled electronic circuitry, storage media, chemical sensors, microscope enhancement, and coating reinforcement. Different methods have been used to grow these CNT's. Some examples are laser ablation, flame synthesis, or furnace synthesis. Every single approach requires the presence of a metal catalyst (Fe, Co, and Ni are among the best) that is small enough to produce a CNT. Herein lies the uniqueness of this work. Microemulsions (containing inverse micelles) were used to generate these metal particles for subsequent CNT growth. The goal of this summer work was basically to accomplish as much preliminary work as possible. I strived to pinpoint which variable (experimental process, metal product, substrate, method of application, CVD conditions, etc.) was the determining factor in the results. The resulting SEM images were sufficient for the appropriate comparisons to be made. The future work of this project consists of the optimization of the more promising experimental procedures and further exploration onto what exactly dictated the results.

Phase Field Modeling of Microstructure Development in Microgravity

NASA Technical Reports Server (NTRS)

Dantzig, Jonathan A.; Goldenfeld, Nigel

2001-01-01

This newly funded project seeks to extend our NASA-sponsored project on modeling of dendritic microstructures to facilitate collaboration between our research group and those of other NASA investigators. In our ongoing program, we have applied advanced computational techniques to study microstructural evolution in dendritic solidification, for both pure isolated dendrites and directionally solidified alloys. This work has enabled us to compute dendritic microstructures using both realistic material parameters and experimentally relevant processing conditions, thus allowing for the first time direct comparison of phase field computations with laboratory observations. This work has been well received by the materials science and physics communities, and has led to several opportunities for collaboration with scientists working on experimental investigations of pattern selection and segregation in solidification. While we have been able to pursue these collaborations to a limited extent, with some important findings, this project focuses specifically on those collaborations. We have two target collaborations: with Prof. Glicksman's group working on the Isothermal Dendritic Growth Experiment (IDGE), and with Prof. Poirier's group studying directional solidification in Pb-Sb alloys. These two space experiments match well with our two thrusts in modeling, one for pure materials, as in the IDGE, and the other directional solidification. Such collaboration will benefit all of the research groups involved, and will provide for rapid dissemination of the results of our work where it will have significant impact.

On use of ZPR research reactors and associated instrumentation and measurement methods for reactor physics studies

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chauvin, J.P.; Blaise, P.; Lyoussi, A.

2015-07-01

The French atomic and alternative energies -CEA- is strongly involved in research and development programs concerning the use of nuclear energy as a clean and reliable source of energy and consequently is working on the present and future generation of reactors on various topics such as ageing plant management, optimization of the plutonium stockpile, waste management and innovative systems exploration. Core physics studies are an essential part of this comprehensive R and D effort. In particular, the Zero Power Reactor (ZPR) of CEA: EOLE, MINERVE and MASURCA play an important role in the validation of neutron (as well photon) physicsmore » calculation tools (codes and nuclear data). The experimental programs defined in the CEA's ZPR facilities aim at improving the calculation routes by reducing the uncertainties of the experimental databases. They also provide accurate data on innovative systems in terms of new materials (moderating and decoupling materials) and new concepts (ADS, ABWR, new MTR (e.g. JHR), GENIV) involving new fuels, absorbers and coolant materials. Conducting such interesting experimental R and D programs is based on determining and measuring main parameters of phenomena of interest to qualify calculation tools and nuclear data 'libraries'. Determining these parameters relies on the use of numerous and different experimental techniques using specific and appropriate instrumentation and detection tools. Main ZPR experimental programs at CEA, their objectives and challenges will be presented and discussed. Future development and perspectives regarding ZPR reactors and associated programs will be also presented. (authors)« less

3D analysis of vortical structures in an abdominal aortic aneurysm by stereoscopic PIV

NASA Astrophysics Data System (ADS)

Deplano, Valérie; Guivier-Curien, Carine; Bertrand, Eric

2016-11-01

The present work presents an experimental in vitro three-dimensional analysis of the flow dynamics in an abdominal aortic aneurysm (AAA) through stereoscopic particle image velocimetry (SPIV) measurements. The experimental set-up mimics the pathophysiological context involving a shear thinning blood analogue fluid, compliant AAA and aorto-iliac bifurcation walls and controlled inlet and outlet flow rate and pressure waveforms as well as working fluid temperature. SPIV was carefully calibrated and conducted to assess the three velocity components in the AAA volume. For the first time in the literature, the 3D vortex ring genesis, propagation, and vanishing in the AAA bulge are experimentally described and quantified. In comparison with classical 2-component PIV measurements (2C PIV), the third component of the velocity vector was shown to be of importance in such a geometry, especially, during the deceleration phase of the flow rate. The 3D velocity magnitude reached up more than 20 % of the 2D one showing that 2C PIV are definitively not accurate enough to provide a complete description of flow behaviour in an AAA. In addition to potential clinical implications of a full 3D vortex ring description in AAA evolution, the 3D in vitro experimental quantification of the flow dynamics carried out in the present study offers an interesting tool for the validation of fluid-structure interaction numerical studies dealing with AAA.

Composition of Web Services Using Markov Decision Processes and Dynamic Programming

PubMed Central

Uc-Cetina, Víctor; Moo-Mena, Francisco; Hernandez-Ucan, Rafael

2015-01-01

We propose a Markov decision process model for solving the Web service composition (WSC) problem. Iterative policy evaluation, value iteration, and policy iteration algorithms are used to experimentally validate our approach, with artificial and real data. The experimental results show the reliability of the model and the methods employed, with policy iteration being the best one in terms of the minimum number of iterations needed to estimate an optimal policy, with the highest Quality of Service attributes. Our experimental work shows how the solution of a WSC problem involving a set of 100,000 individual Web services and where a valid composition requiring the selection of 1,000 services from the available set can be computed in the worst case in less than 200 seconds, using an Intel Core i5 computer with 6 GB RAM. Moreover, a real WSC problem involving only 7 individual Web services requires less than 0.08 seconds, using the same computational power. Finally, a comparison with two popular reinforcement learning algorithms, sarsa and Q-learning, shows that these algorithms require one or two orders of magnitude and more time than policy iteration, iterative policy evaluation, and value iteration to handle WSC problems of the same complexity. PMID:25874247

Development of Laboratory Investigations in Disorders of Sex Development.

PubMed

Audí, Laura; Camats, Núria; Fernández-Cancio, Mónica; Granada, María L

2018-01-01

Scientific knowledge to understand the biological basis of sex development was prompted by the observation of variants different from the 2 most frequent body types, and this became one of the fields first studied by modern pediatric endocrinology. The clinical observation was supported by professionals working in different areas of laboratory sciences which led to the description of adrenal and gonadal steroidogenesis, the enzymes involved, and the different deficiencies. Steroid hormone measurements evolved from colorimetry to radioimmunoassay (RIA) and automated immunoassays, although gas and liquid chromatography coupled to mass spectrometry are now the gold standard techniques for steroid measurements. Peptide hormones and growth factors were purified, and their measurement evolved from RIA to automated immunoassays. Hormone action mechanisms were described, and their specific receptors were characterized and assayed in experimental materials and in patient tissues and cell cultures. The discovery of the genetic basis for variant sex developments began with the description of the sex chromosomes. Molecular technology allowed cloning of genes coding for the different proteins involved in sex determination and development. Experimental animal models aided in verifying the roles of proteins and also suggested new genes to be investigated. New candidate genes continue to be described based on experimental models and on next-generation sequencing of patient DNAs. © 2017 S. Karger AG, Basel.

Inflammation as a therapeutic target in myocardial infarction: learning from past failures to meet future challenges

PubMed Central

Saxena, Amit; Russo, Ilaria; Frangogiannis, Nikolaos G

2015-01-01

In the infarcted myocardium, necrotic cardiomyocytes release danger signals, activating an intense inflammatory response. Inflammatory pathways play a crucial role in regulation of a wide range of cellular processes involved in injury, repair and remodeling of the infarcted heart. Pro-inflammatory cytokines, such as tumor necrosis factor-a and interleukin (IL)-1, are markedly upregulated in the infarcted myocardium and promote adhesive interactions between endothelial cells and leukocytes, by stimulating chemokine and adhesion molecule expression. Distinct chemokine/chemokine receptor pairs are implicated in recruitment of various leukocyte subpopulations in the infarcted myocardium. Over the last 30 years, extensive experimental work has explored the role of inflammatory signals and the contributions of leukocyte subpopulations, in myocardial infarction. Robust evidence derived from experimental models of myocardial infarction has identified inflammatory targets that may attenuate cardiomyocyte injury, or protect from adverse remodeling. Unfortunately, attempts to translate the promising experimental findings to clinical therapy have failed. This review manuscript discusses the biology of the inflammatory response following myocardial infarction, attempts to identify the causes for the translational failures of the past, and proposes promising new therapeutic directions. Because of their potential involvement in injurious, reparative and regenerative responses, inflammatory cells may hold the key for design of new therapies in myocardial infarction. PMID:26241027

Numerical simulation of gender differences in a long-term microgravity exposure

NASA Astrophysics Data System (ADS)

Perez-Poch, Antoni

The objective of this work is to analyse and simulate gender differences when individuals are exposed to long-term microgravity. Risk probability of a health impairment which may put in jeopardy a long-term mission is also evaluated. Computer simulations are becoming a promising research line of work, as physiological models become more and more sophisticated and reliable. Technological advances in state-of-the-art hardware technology and software allow nowadays for better and more accurate simulations of complex phenomena, such as the response of the human cardiovascular system to long-term exposure to microgravity. Experimental data for long-term missions are difficult to achieve and reproduce, therefore the predictions of computer simulations are of a major importance in this field. Our approach is based on a previous model developed and implemented in our laboratory (NELME: Numerical Evaluation of Long-term Microgravity Effects). The software simulates the behaviour of the cardiovascular system and different human organs, has a modular architecture, and allows to introduce perturbations such as physical exercise or countermeasures. The implementation is based on a complex electricallike model of this control system, using inexpensive software development frameworks, and has been tested and validated with the available experimental data. Gender differences have been implemented for this specific work, as an adjustment of a number of parameters that are included in the model. Women versus men physiological differences have been therefore taken into account, based upon estimations from the physiology bibliography. A number of simulations have been carried out for long-term exposure to microgravity. Gravity varying from Earth-based to zero, and time exposure are the two main variables involved in the construction of results, including responses to patterns of physical aerobical exercise, and also thermal stress simulating an extra-vehicular activity. Results show that significant differences appear between men and women physiological response after long-term exposure (more than three months) to microgravity. Risk evaluation for every gender, and specific risk thresholds are provided. Initial results are compatible with the existing data, and provide unique information regarding different patterns of microgravity exposure. We conclude that computer-based models such us NELME are a promising line of work to predict health risks in long-term missions. More experimental work is needed to adjust some parameters of the model. This work may be seen as another contribution to a better understanding of the underlying processes involved for both women in man adaptation to long-term microgravity.

Numerical model updating technique for structures using firefly algorithm

NASA Astrophysics Data System (ADS)

Sai Kubair, K.; Mohan, S. C.

2018-03-01

Numerical model updating is a technique used for updating the existing experimental models for any structures related to civil, mechanical, automobiles, marine, aerospace engineering, etc. The basic concept behind this technique is updating the numerical models to closely match with experimental data obtained from real or prototype test structures. The present work involves the development of numerical model using MATLAB as a computational tool and with mathematical equations that define the experimental model. Firefly algorithm is used as an optimization tool in this study. In this updating process a response parameter of the structure has to be chosen, which helps to correlate the numerical model developed with the experimental results obtained. The variables for the updating can be either material or geometrical properties of the model or both. In this study, to verify the proposed technique, a cantilever beam is analyzed for its tip deflection and a space frame has been analyzed for its natural frequencies. Both the models are updated with their respective response values obtained from experimental results. The numerical results after updating show that there is a close relationship that can be brought between the experimental and the numerical models.

Torsion Tests of Stiffened Circular Cylinders

NASA Technical Reports Server (NTRS)

Moore, R L; Wescoat, C

1944-01-01

The design of curved sheet panels to resist shear involves a consideration of several factors: the buckling resistance of the sheet, the stress at which buckling becomes permanent, and the strength which may be developed beyond the buckling limit by tension-field action. Although some experimental as well as theoretical work has been done on the buckling and tension-field phases of this problem, neither of these types of action appears to be very well understood. The problem is of sufficient importance from the standpoint of aircraft design, it is believed, to warrant further experimental investigation. This report presents the results of the first series of torsion tests of stiffened circular cylinders to be completed in connection with this study at Aluminum Research Laboratories. (author)

Synthesis, characterization and relativistic DFT studies of fac-Re(CO)3(isonicotinic acid)2Cl complex

NASA Astrophysics Data System (ADS)

Zúñiga, César; Oyarzún, Diego P.; Martin-Transaco, Rudy; Yáñez-S, Mauricio; Tello, Alejandra; Fuentealba, Mauricio; Cantero-López, Plinio; Arratia-Pérez, Ramiro

2017-11-01

In this work, new fac-Re(CO)3(PyCOOH)2Cl from isonicotinic acid ligand has been prepared. The complex was characterized by structural (single-crystal X-ray diffraction), elemental analysis and spectroscopic (FTIR, NMR, UV-vis spectroscopy) methods. DFT and TDDFT calculations were performed to obtain the electronic transitions involved in their UV-Vis spectrum. The excitation energies agree with the experimental results. The TDDFT calculations suggest that experimental mixed absorption bands at 270 and 314 nm could be assigned to (MLCT-LLCT)/MLCT transitions. Natural Bond Orbitals (NBO) approach has enabled studying the effects of bonding interactions. E(2) energies confirm the occurrence of ICT (Intra-molecular Charge Transfer) within the molecule.

Experimental Investigation of Supersonic Coplanar Jets within Ejectors

NASA Technical Reports Server (NTRS)

Papamoschou, Dimitri

2001-01-01

This experimental and theoretical work involved reduction of supersonic jet noise using Mach Wave Elimination (MWE), a method that suppresses noise by means of a gaseous layer that envelops the supersonic jet. Also explored was a new method for mixing enhancement in which an axial, secondary flow enhances mixing in a primary flow. The research is relevant to the advent of future supersonic transports that must adhere to the same take-off and landing restrictions as ordinary subsonic aircraft. To reduce noise, one needs to understand the fundamental fluid mechanics of the jet, namely its turbulent structure and mean-flow characteristics, and to perform high-quality noise measurements. The results generated are applicable to free jets as well as to jets within ejectors.

Physical and mathematical modelling of ladle metallurgy operations. [steelmaking

NASA Technical Reports Server (NTRS)

El-Kaddah, N.; Szekely, J.

1982-01-01

Experimental measurements are reported, on the velocity fields and turbulence parameters on a water model of an argon stirred ladle. These velocity measurements are complemented by direct heat transfer measurements, obtained by studying the rate at which ice rods immersed into the system melt, at various locations. The theoretical work undertaken involved the use of the turbulence Navier-Stokes equations in conjunction with the kappa-epsilon model to predict the local velocity fields and the maps of the turbulence parameters. Theoretical predictions were in reasonably good agreement with the experimentally measured velocity fields; the agreement between the predicted and the measured turbulence parameters was less perfect, but still satisfactory. The implications of these findings to the modelling of ladle metallurgical operations are discussed.

Note: Setup for chemical atmospheric control during in situ grazing incidence X-ray scattering of printed thin films

DOE PAGES

Pröller, Stephan; Moseguí González, Daniel; Zhu, Chenhuii; ...

2017-06-01

In order to tailor the assembling of polymers and organic molecules, a deeper understanding of the kinetics involved in thin film production is necessary. While post-production characterization only provides insight on the final film structure, more sophisticated experimental setups are needed to probe the structure formation processes in situ during deposition. The drying kinetics of a deposited organic thin film strongly influences the assembling process on the nanometer scale. Lastly, this work presents an experimental setup that enables fine control of the atmosphere composition surrounding the sample during slot die coating, while simultaneously probing the film formation kinetics using inmore » situ grazing incidence X-ray scattering and spectroscopy.« less

Approximate numerical abilities and mathematics: Insight from correlational and experimental training studies.

PubMed

Hyde, D C; Berteletti, I; Mou, Y

2016-01-01

Humans have the ability to nonverbally represent the approximate numerosity of sets of objects. The cognitive system that supports this ability, often referred to as the approximate number system (ANS), is present in early infancy and continues to develop in precision over the life span. It has been proposed that the ANS forms a foundation for uniquely human symbolic number and mathematics learning. Recent work has brought two types of evidence to bear on the relationship between the ANS and human mathematics: correlational studies showing individual differences in approximate numerical abilities correlate with individual differences in mathematics achievement and experimental studies showing enhancing effects of nonsymbolic approximate numerical training on exact, symbolic mathematical abilities. From this work, at least two accounts can be derived from these empirical data. It may be the case that the ANS and mathematics are related because the cognitive and brain processes responsible for representing numerical quantity in each format overlap, the Representational Overlap Hypothesis, or because of commonalities in the cognitive operations involved in mentally manipulating the representations of each format, the Operational Overlap hypothesis. The two hypotheses make distinct predictions for future work to test. © 2016 Elsevier B.V. All rights reserved.

An experimental work on wireless structural health monitoring system applying on a submarine model scale

NASA Astrophysics Data System (ADS)

Nugroho, W. H.; Purnomo, N. J. H.; Soedarto, T.

2016-11-01

This paper presents an experimental work to monitor the health of submarine hull structures using strain sensors and wireless communication technology. The monitored - submarine hull was built in a hydro elastic model scale 1: 30 with a steel bar backbone and tested on water tank of Indonesian Hydrodynamic Laboratory (IHL). Specifically, this health monitoring system for the submarine model was developed using wireless modems, data communication software and conventional strain sensors. This system was used to monitor the loads on a steel bar backbone of the running submarine model from the edge of the water tank. Commands were issued from a notebook to instruct the health monitoring system to acquire data from sensors mounted externally to the steel bar. Data from measurements made on the structure are then transmitted wirelessly back to a notebook computer for processing and analysis. The results of the tank test have been validated and showed no loss of communication signal over an area of the tank. This work also presents a potential use of involving complete automation of this system with an in-service structure coupled with an on-line warning/damage detection capability.

A review and preliminary evaluation of methodological factors in performance assessments of time-varying aircraft noise effects

NASA Technical Reports Server (NTRS)

Coates, G. D.; Alluisi, E. A.

1975-01-01

The effects of aircraft noise on human performance is considered. Progress is reported in the following areas: (1) review of the literature to identify the methodological and stimulus parameters involved in the study of noise effects on human performance; (2) development of a theoretical framework to provide working hypotheses as to the effects of noise on complex human performance; and (3) data collection on the first of several experimental investigations designed to provide tests of the hypotheses.

Consequence Assessment Methods for Incidents Involving Releases From Liquefied Natural Gas Carriers

DTIC Science & Technology

2004-05-13

the downwind direction. The Thomas (1965) correlation is used to calculate flame length . Flame tilt is estimated using an empirical correlation from...follows: From TNO (1997) • Thomas (1963) correlation for flame length • For an experimental LNG pool fire of 16.8-m diameter, a mass burning flux of...m, flame length ranged from 50 to 78 m, and tilt angle from 27 to 35 degrees From Rew (1996) • Work included a review of recent developments in

The development of low temperature curing adhesives

NASA Technical Reports Server (NTRS)

Green, H. E.; Sutherland, J. D.; Hom, J. M.; Sheppard, C. H.

1975-01-01

An approach for the development of a practical low temperature (293 K-311 K/68 F-100 F) curing adhesive system based on a family of amide/ester resins was studied and demonstrated. The work was conducted on resin optimization and adhesive compounding studies. An improved preparative method was demonstrated which involved the reaction of an amine-alcohol precursor, in a DMF solution with acid chloride. Experimental studies indicated that an adhesive formulation containing aluminum powder provided the best performance when used in conjunction with a commercial primer.

Polymorphism at the ref(2)P locus in Drosophila melanogaster: preliminary experiments concerning the selection mechanisms involved in its maintenance.

PubMed

Fleuriet, A

1981-02-01

It has been shown previously that a polymorphism for two alleles of the ref(2)P locus is a regular feature of French natural populations of Drosophila melanogaster and that this is maintained in laboratory populations raised in cages. In this paper, an experimental population and egg-collection experiments are reported. Differential survival of the three genotypes would be the main factor leading to the equilibrium frequencies, working only in drastic conditions of larval competition.

Conference Proceedings on Guidance and Control Techniques for Advanced Space Vehicles (37th) Held at Florence, Italy on 27-30 September 1983.

DTIC Science & Technology

1984-01-01

P AD-A14l 969 CONFERENCE PROCEEDINGS ON GUIDANCE AND CONTROL 1 TECHNIQUES FOR ADVANCED SP-.(U,) ADVISORY GROUP FOR AEROSPACE RESEARCH AND DEVELOPMENT...findings of these various planning groups relativie to the ’e for advanced controls technology, and the perceived status of the technology t. me-,t... control of large flexible spacecraft. The program has also involved experimental activities to guide Ind validate the theoretical work. The

The pair-production channel in atomic processes

NASA Astrophysics Data System (ADS)

Belkacem, Ali; Sørensen, Allan H.

2006-06-01

Assisted by the creation of electron-positron pairs, new channels for ionization, excitation, and charge transfer open in atomic collisions when the energy is raised to relativistic values. At extreme energies these pair-production channels usually dominate the "traditional" contributions to cross sections that involve only "positive-energy" electrons. An extensive body of theoretical and experimental work has been performed over the last two decades to investigate charge-changing processes catalyzed by pair production in relativistic heavy ion collisions. We review some of these studies.

Visual monitoring of autonomous life sciences experimentation

NASA Technical Reports Server (NTRS)

Blank, G. E.; Martin, W. N.

1987-01-01

The design and implementation of a computerized visual monitoring system to aid in the monitoring and control of life sciences experiments on board a space station was investigated. A likely multiprocessor design was chosen, a plausible life science experiment with which to work was defined, the theoretical issues involved in the programming of a visual monitoring system for the experiment was considered on the multiprocessor, a system for monitoring the experiment was designed, and simulations of such a system was implemented on a network of Apollo workstations.

The Discovery of the Higgs Boson: America's Role

ScienceCinema

None

2018-05-30

The discovery of the Higgs boson was an international endeavor, involving thousands of physicists from across the world. While the accelerator at which the experimental work was done is located on Europe, the US supplied more physicists than any other single country. America had a very large role in the discovery of the Higgs particle and continues to have a leading role in the ongoing studies of the boson's properties. This video describes some of the contributions of U.S. universities and laboratories.

Early-\\x90stage Electrical Breakdown involving Tunneling

NASA Astrophysics Data System (ADS)

Hjalmarson, Harold; Moore, Chris; Schultz, Peter; Bussman, Ezra; Scrymgeour, David; Hopkins, Matt

The early stage of electrical breakdown from a surface is assumed to involve field emission. In real-world applications, the electrical field is often assumed to be increased by geometrical effects. In addition to these enhancement effects, contamination by adsorbates can lead to reductions in the effective work functions. To develop a physics-based understanding beyond the use of these empirical effects, the field emission currents at early times are being computed and measured. The calculations involve a solution of the Boltzmann equation, and the measurements involve a scanning tunneling microscope. Early results from this collaborative theoretical-experimental project will be described in this presentation. The presentation will focus on results for an ideal system with an absence of geometrical effects. Sandia National Laboratories is a multi-mission laboratory managed and operated by Sandia Corporation, a wholly owned subsidiary of Lockheed Martin Corporation, for the U.S. Department of Energy's National Nuclear Security Administration under contract DE-AC04-94AL85000.

Experimental investigation of defect criticality in FRP laminate composites

NASA Astrophysics Data System (ADS)

Joyce, Peter James

1999-11-01

This work examines the defect criticality of fiber reinforced polymer Composites. The objective is to determine the sensitivity of the finished composite to various process-induced defects. This work focuses on two different classes of process-induced defects; (1) fiber waviness in high performance carbon-fiber reinforced unidirectional composites and (2) void volume in low cost glass-fabric reinforced composites. The role of fiber waviness in the compressive response of unidirectional composites has been studied by a number of other investigators. Because of difficulties associated with producing real composites with varying levels of fiber waviness, most experimental studies of fiber waviness have evaluated composites with artificially induced fiber waviness. Furthermore, most experimental studies have been concentrated on the effects of out-of-plane fiber waviness. The objective of this work is to evaluate the effects of in-plane fiber waviness naturally occurring in autoclave consolidated thermoplastic laminates. The first phase of this project involved the development of a simple technique for measuring the resulting fiber waviness levels. An experimental investigation of the compression strength reduction in composites with in-plane fiber waviness followed. The experimental program included carbon-fiber reinforced thermoplastic composites manufactured from prepreg tape by hand layup, and carbon-fiber and glass-fiber reinforced composites manufactured from an experimental powder towpreg by filament winding and autoclave consolidation. The compression specimens exhibited kink band failure in the prepreg composite and varying amounts of longitudinal splitting and kink banding in the towpreg composites. The compression test results demonstrated the same trend as predicted by microbudding theory but the overall quantitative correlation was poor. The second thrust of this research evaluated void effects in resin transfer molded composites. Much of the existing literature in this area has focused on composites with unidirectional fiber reinforcement. In this program, the influence of void volume on the mechanical behavior of RTM composites with plain weave reinforcement was investigated. The experimental program demonstrated that the effects of void volume are negligible in terms of the fiber dominated properties. Interlaminar shear strength tests on the other hand demonstrated a linear dependence on void volume in the range tested.

Boundary Electron and Beta Dosimetry-Quantification of the Effects of Dissimilar Media on Absorbed Dose

NASA Astrophysics Data System (ADS)

Nunes, Josane C.

1991-02-01

This work quantifies the changes effected in electron absorbed dose to a soft-tissue equivalent medium when part of this medium is replaced by a material that is not soft -tissue equivalent. That is, heterogeneous dosimetry is addressed. Radionuclides which emit beta particles are the electron sources of primary interest. They are used in brachytherapy and in nuclear medicine: for example, beta -ray applicators made with strontium-90 are employed in certain ophthalmic treatments and iodine-131 is used to test thyroid function. More recent medical procedures under development and which involve beta radionuclides include radioimmunotherapy and radiation synovectomy; the first is a cancer modality and the second deals with the treatment of rheumatoid arthritis. In addition, the possibility of skin surface contamination exists whenever there is handling of radioactive material. Determination of absorbed doses in the examples of the preceding paragraph requires considering boundaries of interfaces. Whilst the Monte Carlo method can be applied to boundary calculations, for routine work such as in clinical situations, or in other circumstances where doses need to be determined quickly, analytical dosimetry would be invaluable. Unfortunately, few analytical methods for boundary beta dosimetry exist. Furthermore, the accuracy of results from both Monte Carlo and analytical methods has to be assessed. Although restricted to one radionuclide, phosphorus -32, the experimental data obtained in this work serve several purposes, one of which is to provide standards against which calculated results can be tested. The experimental data also contribute to the relatively sparse set of published boundary dosimetry data. At the same time, they may be useful in developing analytical boundary dosimetry methodology. The first application of the experimental data is demonstrated. Results from two Monte Carlo codes and two analytical methods, which were developed elsewhere, are compared with experimental data. Monte Carlo results compare satisfactory with experimental results for the boundaries considered. The agreement with experimental results for air interfaces is of particular interest because of discrepancies reported previously by another investigator who used data obtained from a different experimental technique. Results from one of the analytical methods differ significantly from the experimental data obtained here. The second analytical method provided data which approximate experimental results to within 30%. This is encouraging but it remains to be determined whether this method performs equally well for other source energies.

Mass transport phenomena between bubbles and dissolved gases in liquids under reduced gravity conditions

NASA Technical Reports Server (NTRS)

Dewitt, Kenneth J.; Brockwell, Jonathan L.; Yung, Chain-Nan; Chai, An-Ti; Mcquillen, John B.; Sotos, Raymond G.; Neumann, Eric S.

1988-01-01

The experimental and analytical work that was done to establish justification and feasibility for a shuttle middeck experiment involving mass transfer between a gas bubble and a liquid is described. The experiment involves the observation and measurement of the dissolution of an isolated immobile gas bubble of specified size and composition in a thermostatted solvent liquid of known concentration in the reduced gravity environment of earth orbit. Methods to generate and deploy the bubble were successful both in normal gravity using mutually buoyant fluids and under reduced gravity conditions in the NASA Lear Jet. Initialization of the experiment with a bubble of a prescribed size and composition in a liquid of known concentration was accomplished using the concept of unstable equilibrium. Subsequent bubble dissolution or growth is obtained by a step increase or decrease in the liquid pressure. A numerical model was developed which simulates the bubble dynamics and can be used to determine molecular parameters by comparison with the experimental data. The primary objective of the experiment is the elimination of convective effects that occur in normal gravity.

A novel pathway for the biosynthesis of heme in Archaea: genome-based bioinformatic predictions and experimental evidence.

PubMed

Storbeck, Sonja; Rolfes, Sarah; Raux-Deery, Evelyne; Warren, Martin J; Jahn, Dieter; Layer, Gunhild

2010-12-13

Heme is an essential prosthetic group for many proteins involved in fundamental biological processes in all three domains of life. In Eukaryota and Bacteria heme is formed via a conserved and well-studied biosynthetic pathway. Surprisingly, in Archaea heme biosynthesis proceeds via an alternative route which is poorly understood. In order to formulate a working hypothesis for this novel pathway, we searched 59 completely sequenced archaeal genomes for the presence of gene clusters consisting of established heme biosynthetic genes and colocalized conserved candidate genes. Within the majority of archaeal genomes it was possible to identify such heme biosynthesis gene clusters. From this analysis we have been able to identify several novel heme biosynthesis genes that are restricted to archaea. Intriguingly, several of the encoded proteins display similarity to enzymes involved in heme d(1) biosynthesis. To initiate an experimental verification of our proposals two Methanosarcina barkeri proteins predicted to catalyze the initial steps of archaeal heme biosynthesis were recombinantly produced, purified, and their predicted enzymatic functions verified.

The Influence of the Heat-Affected Zone Mechanical Properties on the Behaviour of the Welding in Transverse Plate-to-Tube Joints.

PubMed

Lozano, Miguel; Serrano, Miguel A; López-Colina, Carlos; Gayarre, Fernando L; Suárez, Jesús

2018-02-09

Eurocode 3 establishes the component method to analytically characterize the structural joints between beam and columns. When one of the members involved in the joint is a hollow section (i.e., a tube) there is a lack of information for the specific components present in the joint. There are two different ways to bridge the gap: experimental testing on the actual beam column joints involving tubular sections; or numerical modelization, typically by means of finite element analysis. For this second option, it is necessary to know the actual mechanical properties of the material. As long as the joint implies a welding process, there is a concern related to how the mechanical properties in the heat-affected zone (HAZ) influence the behavior of the joint. In this work, some coupons were extracted from the HAZ of the beam-column joint. The coupons were tested and the results were implemented in the numerical model of the joint, in an attempt to bring it closer to the experimental results of the tested joints.

The Johnson Space Center Experimental Impact Lab: Contributions Toward Understanding the Evolution of the Solar System

NASA Technical Reports Server (NTRS)

See, T. H.; Montes, R.

2012-01-01

Impact is the most common and only weathering phenomenon affecting all the planetary bodies (e.g., planets, satellites, asteroids, comets, etc.) in the solar system. NASA Johnson Space Center s Experimental Impact Laboratory (EIL) includes three accelerators that are used in support of research into the effects of impact on the formation and evolution of the solar system. They permit researchers to study a wide variety of phenomena associated with high-velocity impacts into a wide range of geologic targets and materials relevant to astrobiological studies. By studying these processes, researchers can investigate the histories and evolution of planetary bodies and the solar system as a whole. While the majority of research conducted in the EIL addresses questions involving planetary impacts, work involving spacecraft components has been performed on occasion. An example of this is the aerogel collector material flown on the Stardust spacecraft that traveled to Comet Wild-2. This capture medium was tested and flight qualified using the 5 mm Light-Gas Gun located in the EIL.

A Novel Pathway for the Biosynthesis of Heme in Archaea: Genome-Based Bioinformatic Predictions and Experimental Evidence

PubMed Central

Storbeck, Sonja; Rolfes, Sarah; Raux-Deery, Evelyne; Warren, Martin J.; Jahn, Dieter; Layer, Gunhild

2010-01-01

Heme is an essential prosthetic group for many proteins involved in fundamental biological processes in all three domains of life. In Eukaryota and Bacteria heme is formed via a conserved and well-studied biosynthetic pathway. Surprisingly, in Archaea heme biosynthesis proceeds via an alternative route which is poorly understood. In order to formulate a working hypothesis for this novel pathway, we searched 59 completely sequenced archaeal genomes for the presence of gene clusters consisting of established heme biosynthetic genes and colocalized conserved candidate genes. Within the majority of archaeal genomes it was possible to identify such heme biosynthesis gene clusters. From this analysis we have been able to identify several novel heme biosynthesis genes that are restricted to archaea. Intriguingly, several of the encoded proteins display similarity to enzymes involved in heme d 1 biosynthesis. To initiate an experimental verification of our proposals two Methanosarcina barkeri proteins predicted to catalyze the initial steps of archaeal heme biosynthesis were recombinantly produced, purified, and their predicted enzymatic functions verified. PMID:21197080

Digital Literacy Development of Students Involved in an ICT Educational Project

NASA Astrophysics Data System (ADS)

Quintana, Maria Graciela Badilla; Pujol, Meritxell Cortada

The impact of the Information and Communication Technologies (ICT) has become the core of a change that involves most of the society fields, consequently the technological and informational literacy are essential requirements in education. The research is a quasi-experimental and ex-post-facto study in schools from Spain. The aim was to describe and analyze the involvement showed by 219 students who participated in a development of ICT's Project named Ponte dos Brozos. The research objective was to respond if the students who usually worked with ICT, had better knowledge and management with computing tools, and if they are better prepared in researching and selecting information. Results showed that students who have a higher contact with ICTs know about the technology and how to use it, also better knowledge and control of the computer and operative systems, a high information management level trough the Internet, although their literacy in information is devoid.

A theoretical study of thorium titanium-based alloys

NASA Astrophysics Data System (ADS)

Obodo, K. O.; Chetty, N.

2013-09-01

Using theoretical quantum chemical methods, we investigate the dearth of ordered alloys involving thorium and titanium. Whereas both these elements are known to alloy very readily with various other elements, for example with oxygen, current experimental data suggests that Th and Ti do not alloy very readily with each other. In this work, we consider a variety of ordered alloys at varying stoichiometries involving these elements within the framework of density functional theory using the generalized gradient approximation for the exchange and correlation functional. By probing the energetics, electronic, phonon and elastic properties of these systems, we confirm the scarcity of ordered alloys involving Th and Ti, since for a variety of reasons many of the systems that we considered were found to be unfavorable. However, our investigations resulted in one plausible ordered structure: We propose ThTi3 in the Cr3Si structure as a metastable ordered alloy.

Instability of multi-layer fluid configurations in the presence of time-dependent accelerations in a microgravity environment

NASA Technical Reports Server (NTRS)

Lyell, M. J.; Roh, Michael

1991-01-01

The increasing number of research opportunities in a microgravity environment will benefit not only fundamental studies in fluid dynamics, but also technological applications such as those involving materials processing. In particular, fluid configurations which involve fluid-fluid interfaces would occur in a variety of experimental investigations. This work investigates the stability of a configuration involving fluid-fluid interfaces in the presence of a time-dependent forcing. Both periodic (g-jitter) and nonperiodic accelerations are considered. The fluid configuration is multilayered, and infinite in extent. The analysis is linear and inviscid, and the acceleration vector is oriented perpendicular to each interface. A Floquet analysis is employed in the case of the periodic forcing. In the problem of nonperiodic forcing, the resulting system of equations are integrated in time. Specific nondimensional parameters appear in each problem. The configuration behavior is investigated for a range of parameter values.

Measuring and Advancing Experimental Design Ability in an Introductory Course without Altering Existing Lab Curriculum.

PubMed

Shanks, Ryan A; Robertson, Chuck L; Haygood, Christian S; Herdliksa, Anna M; Herdliska, Heather R; Lloyd, Steven A

2017-01-01

Introductory biology courses provide an important opportunity to prepare students for future courses, yet existing cookbook labs, although important in their own way, fail to provide many of the advantages of semester-long research experiences. Engaging, authentic research experiences aid biology students in meeting many learning goals. Therefore, overlaying a research experience onto the existing lab structure allows faculty to overcome barriers involving curricular change. Here we propose a working model for this overlay design in an introductory biology course and detail a means to conduct this lab with minimal increases in student and faculty workloads. Furthermore, we conducted exploratory factor analysis of the Experimental Design Ability Test (EDAT) and uncovered two latent factors which provide valid means to assess this overlay model's ability to increase advanced experimental design abilities. In a pre-test/post-test design, we demonstrate significant increases in both basic and advanced experimental design abilities in an experimental and comparison group. We measured significantly higher gains in advanced experimental design understanding in students in the experimental group. We believe this overlay model and EDAT factor analysis contribute a novel means to conduct and assess the effectiveness of authentic research experiences in an introductory course without major changes to the course curriculum and with minimal increases in faculty and student workloads.

Metabolism of Cryptic Peptides Derived from Neuropeptide FF Precursors: The Involvement of Insulin-Degrading Enzyme

PubMed Central

Grasso, Giuseppe; Mielczarek, Przemyslaw; Niedziolka, Magdalena; Silberring, Jerzy

2014-01-01

The term “cryptome” refers to the subset of cryptic peptides with bioactivities that are often unpredictable and very different from the parent protein. These cryptic peptides are generated by proteolytic cleavage of proteases, whose identification in vivo can be very challenging. In this work, we show that insulin-degrading enzyme (IDE) is able to degrade specific amino acid sequences present in the neuropeptide pro-NPFFA (NPFF precursor), generating some cryptic peptides that are also observed after incubation with rat brain cortex homogenate. The reported experimental findings support the increasingly accredited hypothesis, according to which, due to its wide substrate selectivity, IDE is involved in a wide variety of physiopathological processes. PMID:25247577

Microwave Tunable Metamaterial Based on Semiconductor-to-Metal Phase Transition.

PubMed

Zhang, Guanqiao; Ma, He; Lan, Chuwen; Gao, Rui; Zhou, Ji

2017-07-18

A microwave tunable metamaterial utilizing the semiconductor-to-metal transition of vanadium dioxide (VO 2 ) is proposed, experimentally demonstrated and theoretically scrutinized. Basic concept of the design involves the combination of temperature-dependent hysteresis in VO 2 with resonance induced heating, resulting in a nonlinear response to power input. A lithographically prepared gold split-rings resonator (SRR) array deposited with VO 2 thin film is fabricated. Transmission spectra analysis shows a clear manifestation of nonlinearity, involving power-dependence of resonant frequency as well as transmitted intensity at both elevated and room temperature. Simulation performed with CST Microwave Studio conforms with the findings. The concept may find applications in transmission modulation and frequency tuning devices working under microwave frequency bands.

Using the Git Software Tool on the Peregrine System | High-Performance

Science.gov Websites

branch workflow. Create a local branch called "experimental" based on the current master... git branch experimental Use your branch (start working on that experimental branch....) git checkout experimental git pull origin experimental # work, work, work, commit.... Send local branch to the repo git push

Numerical modelling of hydrologically-driven slope instability by means of porous media mechanics

NASA Astrophysics Data System (ADS)

Kakogiannou, Evanthia; Sanavia, Lorenzo; Lora, Marco; Schrefler, Bernhard

2015-04-01

Heavy rainfall can trigger slope failure which generally involves shallow soil deposit of different grading and origin usually in a state of partial saturation. In this case of slope instability, the behaviour of the soil slope is closely related not only to the distribution of pore-water pressure but also to the stress state during rainfall infiltration involving both mechanical and hydrological processes. In order to understand better these physical key processes, in this research work, the modelling of rainfall induced slope failure is considered as a coupled variably saturated hydro-mechanical problem. Therefore, the geometrically linear finite element code Comes-Geo for non-isothermal elasto-plastic multiphase solid porous materials is used, as developed by B.A. Schrefler and his co-workers. In this context, a detailed numerical analysis of an experimental slope stability test due to rainfall infiltration is presented. The main goals of this work are to understand the triggering mechanisms during the progressive failure, the effect of using different constitutive models of the mechanical soil behavior on the numerical results and the use of the second order work criterion on the detection of slope instability.

Quantum simulations and many-body physics with light.

PubMed

Noh, Changsuk; Angelakis, Dimitris G

2017-01-01

In this review we discuss the works in the area of quantum simulation and many-body physics with light, from the early proposals on equilibrium models to the more recent works in driven dissipative platforms. We start by describing the founding works on Jaynes-Cummings-Hubbard model and the corresponding photon-blockade induced Mott transitions and continue by discussing the proposals to simulate effective spin models and fractional quantum Hall states in coupled resonator arrays (CRAs). We also analyse the recent efforts to study out-of-equilibrium many-body effects using driven CRAs, including the predictions for photon fermionisation and crystallisation in driven rings of CRAs as well as other dynamical and transient phenomena. We try to summarise some of the relatively recent results predicting exotic phases such as super-solidity and Majorana like modes and then shift our attention to developments involving 1D nonlinear slow light setups. There the simulation of strongly correlated phases characterising Tonks-Girardeau gases, Luttinger liquids, and interacting relativistic fermionic models is described. We review the major theory results and also briefly outline recent developments in ongoing experimental efforts involving different platforms in circuit QED, photonic crystals and nanophotonic fibres interfaced with cold atoms.

Experimental determination of the effects of annealing on the micro-structures and mechanical properties of cold-worked alpha-brass

NASA Astrophysics Data System (ADS)

Edward, Aghogho Bright; Izelu, Christopher

2013-12-01

Experimental determination of the effect of annealing on the microstructure and mechanical properties of a cold work 70 - 30 brass, was carried out by subjecting specimens of the material to various degrees of cold-work (20%, 40% and 60%), by straining using a tensile machine. The specimens for each degree of cold work were then annealed at 250°C, 350°C, 450°C and 600°C, for 30 minutes. The approach involves the use of metallographic techniques: grinding, polishing and etching to reveal the microstructure while tensile test was carried out on the specimen using a Monsanto tensometer so as to obtain the load/extension graph from which the tensile strength and hardness values were obtained. From the results obtained, it was conclusive that annealing produced finer grains and eliminates prior cold work whereby the material becomes ductile. However, there should be an appreciable deformation for this effect to be noticed. One important aspect of re-crystallization in structural materials is that there is a loss of strength which accompanies disappearance of the cold-worked grains when subjected to high temperature applications. Yet, it is often difficult to establish the exact range of permissible temperature. This work establishes a range for the re-crystallization of alpha brass as 350°C < TC < 450°C, where TC is the re-crystallization temperature. Thus, it will be safe to apply this material at temperatures below 350°C, without fear of structural changes with accompanying lost in strength.

Toward Predictive Theories of Nuclear Reactions Across the Isotopic Chart: Web Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Escher, J. E.; Blackmon, J.; Elster, C.

Recent years have seen exciting new developments and progress in nuclear structure theory, reaction theory, and experimental techniques, that allow us to move towards a description of exotic systems and environments, setting the stage for new discoveries. The purpose of the 5-week program was to bring together physicists from the low-energy nuclear structure and reaction communities to identify avenues for achieving reliable and predictive descriptions of reactions involving nuclei across the isotopic chart. The 4-day embedded workshop focused on connecting theory developments to experimental advances and data needs for astrophysics and other applications. Nuclear theory must address phenomena from laboratorymore » experiments to stellar environments, from stable nuclei to weakly-bound and exotic isotopes. Expanding the reach of theory to these regimes requires a comprehensive understanding of the reaction mechanisms involved as well as detailed knowledge of nuclear structure. A recurring theme throughout the program was the desire to produce reliable predictions rooted in either ab initio or microscopic approaches. At the same time it was recognized that some applications involving heavy nuclei away from stability, e.g. those involving fi ssion fragments, may need to rely on simple parameterizations of incomplete data for the foreseeable future. The goal here, however, is to subsequently improve and refine the descriptions, moving to phenomenological, then microscopic approaches. There was overarching consensus that future work should also focus on reliable estimates of errors in theoretical descriptions.« less

Combustion of interacting droplet arrays in a microgravity environment

NASA Technical Reports Server (NTRS)

Dietrich, Daniel L.; Haggard, John B.

1993-01-01

This research program involves the study of one and two dimensional arrays of droplets in a buoyant-free environment. The purpose of the work is to extend the database and theories that exist for single droplets into the regime where droplet interactions are important. The eventual goal being to use the results of this work as inputs to models on spray combustion where droplets seldom burn individually; instead the combustion history of a droplet is strongly influenced by the presence of the neighboring droplets. The emphasis of the present investigation is experimental, although comparison will be made to existing theoretical and numerical treatments when appropriate. Both normal gravity and low gravity testing will be employed, and the results compared. The work to date will be summarized in the next section, followed by a section detailing the future plans.

Advantages of mixing bioinformatics and visualization approaches for analyzing sRNA-mediated regulatory bacterial networks

PubMed Central

Bourqui, Romain; Benchimol, William; Gaspin, Christine; Sirand-Pugnet, Pascal; Uricaru, Raluca; Dutour, Isabelle

2015-01-01

The revolution in high-throughput sequencing technologies has enabled the acquisition of gigabytes of RNA sequences in many different conditions and has highlighted an unexpected number of small RNAs (sRNAs) in bacteria. Ongoing exploitation of these data enables numerous applications for investigating bacterial transacting sRNA-mediated regulation networks. Focusing on sRNAs that regulate mRNA translation in trans, recent works have noted several sRNA-based regulatory pathways that are essential for key cellular processes. Although the number of known bacterial sRNAs is increasing, the experimental validation of their interactions with mRNA targets remains challenging and involves expensive and time-consuming experimental strategies. Hence, bioinformatics is crucial for selecting and prioritizing candidates before designing any experimental work. However, current software for target prediction produces a prohibitive number of candidates because of the lack of biological knowledge regarding the rules governing sRNA–mRNA interactions. Therefore, there is a real need to develop new approaches to help biologists focus on the most promising predicted sRNA–mRNA interactions. In this perspective, this review aims at presenting the advantages of mixing bioinformatics and visualization approaches for analyzing predicted sRNA-mediated regulatory bacterial networks. PMID:25477348

Advantages of mixing bioinformatics and visualization approaches for analyzing sRNA-mediated regulatory bacterial networks.

PubMed

Thébault, Patricia; Bourqui, Romain; Benchimol, William; Gaspin, Christine; Sirand-Pugnet, Pascal; Uricaru, Raluca; Dutour, Isabelle

2015-09-01

The revolution in high-throughput sequencing technologies has enabled the acquisition of gigabytes of RNA sequences in many different conditions and has highlighted an unexpected number of small RNAs (sRNAs) in bacteria. Ongoing exploitation of these data enables numerous applications for investigating bacterial transacting sRNA-mediated regulation networks. Focusing on sRNAs that regulate mRNA translation in trans, recent works have noted several sRNA-based regulatory pathways that are essential for key cellular processes. Although the number of known bacterial sRNAs is increasing, the experimental validation of their interactions with mRNA targets remains challenging and involves expensive and time-consuming experimental strategies. Hence, bioinformatics is crucial for selecting and prioritizing candidates before designing any experimental work. However, current software for target prediction produces a prohibitive number of candidates because of the lack of biological knowledge regarding the rules governing sRNA-mRNA interactions. Therefore, there is a real need to develop new approaches to help biologists focus on the most promising predicted sRNA-mRNA interactions. In this perspective, this review aims at presenting the advantages of mixing bioinformatics and visualization approaches for analyzing predicted sRNA-mediated regulatory bacterial networks. © The Author 2014. Published by Oxford University Press.

Experimental characterization and macro-modeling of mechanical strength of multi-sheets and multi-materials spot welds under pure and mixed modes I and II

NASA Astrophysics Data System (ADS)

Chtourou, Rim; Haugou, Gregory; Leconte, Nicolas; Zouari, Bassem; Chaari, Fahmi; Markiewicz, Eric

2015-09-01

Resistance Spot Welding (RSW) of multiple sheets with multiple materials are increasingly realized in the automotive industry. The mechanical strength of such new generation of spot welded assemblies is not that much dealt with. This is true in particular for experiments dedicated to investigate the mechanical strength of spot weld made by multi sheets of different grades, and their macro modeling in structural computations. Indeed, the most published studies are limited to two sheet assemblies. Therefore, in the first part of this work an advanced experimental set-up with a reduced mass is proposed to characterize the quasi-static and dynamic mechanical behavior and rupture of spot weld made by several sheets of different grades. The proposed device is based on Arcan test, the plates contribution in the global response is, thus, reduced. Loading modes I/II are, therefore, combined and well controlled. In the second part a simplified spot weld connector element (macroscopic modeling) is proposed to describe the nonlinear response and rupture of this new generation of spot welded assemblies. The weld connector model involves several parameters to be set. The remaining parameters are finally identified through a reverse engineering approach using mechanical responses of experimental tests presented in the first part of this work.

Improving implementation of evidence-based practice in mental health service delivery: protocol for a cluster randomised quasi-experimental investigation of staff-focused values interventions

PubMed Central

2013-01-01

Background There is growing acceptance that optimal service provision for individuals with severe and recurrent mental illness requires a complementary focus on medical recovery (i.e., symptom management and general functioning) and personal recovery (i.e., having a ‘life worth living’). Despite significant research attention and policy-level support, the translation of this vision of healthcare into changed workplace practice continues to elude. Over the past decade, evidence-based training interventions that seek to enhance the knowledge, attitudes, and skills of staff working in the mental health field have been implemented as a primary redress strategy. However, a large body of multi-disciplinary research indicates disappointing rates of training transfer. There is an absence of empirical research that investigates the importance of worker-motivation in the uptake of desired workplace change initiatives. ‘Autonomy’ is acknowledged as important to human effectiveness and as a correlate of workplace variables like productivity, and wellbeing. To our knowledge, there have been no studies that investigate purposeful and structured use of values-based interventions to facilitate increased autonomy as a means of promoting enhanced implementation of workplace change. Methods This study involves 200 mental health workers across 22 worksites within five community-managed organisations in three Australian states. It involves cluster-randomisation of participants within organisation, by work site, to the experimental (values) condition, or the control (implementation). Both conditions receive two days of training focusing on an evidence-based framework of mental health service delivery. The experimental group receives a third day of values-focused intervention and 12 months of values-focused coaching. Well-validated self-report measures are used to explore variables related to values concordance, autonomy, and self-reported implementation success. Audits of work files and staff work samples are reviewed for each condition to determine the impact of implementation. Self-determination theory and theories of organisational change are used to interpret the data. Discussion The research adds to the current knowledge base related to worker motivation and uptake of workplace practice. It describes a structured protocol that aims to enhance worker autonomy for imposed workplace practices. The research will inform how best to measure and conceptualise transfer. These findings will apply particularly to contexts where individuals are not ‘volunteers’ in requisite change processes. Trial registration ACTRN: ACTRN12613000353796. PMID:23819816

Using neighborhood cohesiveness to infer interactions between protein domains.

PubMed

Segura, Joan; Sorzano, C O S; Cuenca-Alba, Jesus; Aloy, Patrick; Carazo, J M

2015-08-01

In recent years, large-scale studies have been undertaken to describe, at least partially, protein-protein interaction maps, or interactomes, for a number of relevant organisms, including human. However, current interactomes provide a somehow limited picture of the molecular details involving protein interactions, mostly because essential experimental information, especially structural data, is lacking. Indeed, the gap between structural and interactomics information is enlarging and thus, for most interactions, key experimental information is missing. We elaborate on the observation that many interactions between proteins involve a pair of their constituent domains and, thus, the knowledge of how protein domains interact adds very significant information to any interactomic analysis. In this work, we describe a novel use of the neighborhood cohesiveness property to infer interactions between protein domains given a protein interaction network. We have shown that some clustering coefficients can be extended to measure a degree of cohesiveness between two sets of nodes within a network. Specifically, we used the meet/min coefficient to measure the proportion of interacting nodes between two sets of nodes and the fraction of common neighbors. This approach extends previous works where homolog coefficients were first defined around network nodes and later around edges. The proposed approach substantially increases both the number of predicted domain-domain interactions as well as its accuracy as compared with current methods. © The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

Jet Mixing Enhancement by Feedback Control

NASA Technical Reports Server (NTRS)

Glauser, Mark; Taylor, Jeffrey

1999-01-01

The objective of this work has been to produce methodologies for high speed jet noise reduction based on natural mechanisms and enhanced feedback control to affect frequencies and structures in a prescribed manner. In this effort the two-point hot wire measurements obtained in the Langley jet facility by Ukeiley were used in conjuction with linear stochastic estimation (LSE) to implement the LSE component of the complementary technique. This method combines the Proper Orthogonal Decomposition (POD) and LSE to provide an experimental low dimensional time dependent description of the flow field. From such a description it should be possible to identify short time high strain rate events in the jet which contribute to the noise. The main task completed for this effort is summarized: LSE experiments were performed at the downstream locations where the two point hot wire measurements have been obtained by Ukeiley. These experiments involved sampling simultaneously hot wire signals from a relatively course spatial grid in gamma and theta. From this simultaneous data, coupled with the two-point measurements of Ukeiley via the LSE components of the complementary technique, an experimental low dimensional description of the jet at 4, 5, 6, 7 and 8 diameters downstream was obtained for Mach numbers of 0.3 and 0.6. We first present an overview of the theory involved. We finish up with a statement of the work performed and finally provide charts from a 1999 APS talk which summarizes the results.

Age differences in attitude change: influences of cognitive resources and motivation on responses to argument quantity.

PubMed

Wang, Mo; Chen, Yiwei

2006-09-01

This study examined the influences of cognitive resources and motivation on how young and older adults process different quantities of persuasive arguments. In the first experiment session, both young and older adults rated their attitudes toward marijuana legalization and capital punishment. After a week, they read either 3 or 9 similar-quality arguments supporting marijuana legalization and capital punishment. Half of participants were assigned to the high-involvement condition (i.e., told that they were going to discuss the arguments later with the experimenter) and the other half were assigned to the low-involvement condition (i.e., given no instructions). After reading the arguments, participants rated their attitudes toward those 2 social issues again. Highly involved young adults changed their attitudes regardless of the quantity of arguments, whereas lowly involved young adults' attitude change was influenced by the argument quantity. Older adults in both high-involvement and low-involvement conditions changed their attitudes according to the argument quantity. Working memory was found to mediate the age effects on attitude change. This finding demonstrated the importance of a cognitive mechanism in accounting for age differences in attitude change.

Neck/shoulder discomfort due to visually demanding experimental near work is influenced by previous neck pain, task duration, astigmatism, internal eye discomfort and accommodation

PubMed Central

Forsman, Mikael; Richter, Hans O.

2017-01-01

Visually demanding near work can cause eye discomfort, and eye and neck/shoulder discomfort during, e.g., computer work are associated. To investigate direct effects of experimental near work on eye and neck/shoulder discomfort, 33 individuals with chronic neck pain and 33 healthy control subjects performed a visual task four times using four different trial lenses (referred to as four different viewing conditions), and they rated eye and neck/shoulder discomfort at baseline and after each task. Since symptoms of eye discomfort may differ depending on the underlying cause, two categories were used; internal eye discomfort, such as ache and strain, that may be caused by accommodative or vergence stress; and external eye discomfort, such as burning and smarting, that may be caused by dry-eye disorders. The cumulative performance time (reflected in the temporal order of the tasks), astigmatism, accommodation response and concurrent symptoms of internal eye discomfort all aggravated neck/shoulder discomfort, but there was no significant effect of external eye discomfort. There was also an interaction effect between the temporal order and internal eye discomfort: participants with a greater mean increase in internal eye discomfort also developed more neck/shoulder discomfort with time. Since moderate musculoskeletal symptoms are a risk factor for more severe symptoms, it is important to ensure a good visual environment in occupations involving visually demanding near work. PMID:28832612

Neck/shoulder discomfort due to visually demanding experimental near work is influenced by previous neck pain, task duration, astigmatism, internal eye discomfort and accommodation.

PubMed

Zetterberg, Camilla; Forsman, Mikael; Richter, Hans O

2017-01-01

Visually demanding near work can cause eye discomfort, and eye and neck/shoulder discomfort during, e.g., computer work are associated. To investigate direct effects of experimental near work on eye and neck/shoulder discomfort, 33 individuals with chronic neck pain and 33 healthy control subjects performed a visual task four times using four different trial lenses (referred to as four different viewing conditions), and they rated eye and neck/shoulder discomfort at baseline and after each task. Since symptoms of eye discomfort may differ depending on the underlying cause, two categories were used; internal eye discomfort, such as ache and strain, that may be caused by accommodative or vergence stress; and external eye discomfort, such as burning and smarting, that may be caused by dry-eye disorders. The cumulative performance time (reflected in the temporal order of the tasks), astigmatism, accommodation response and concurrent symptoms of internal eye discomfort all aggravated neck/shoulder discomfort, but there was no significant effect of external eye discomfort. There was also an interaction effect between the temporal order and internal eye discomfort: participants with a greater mean increase in internal eye discomfort also developed more neck/shoulder discomfort with time. Since moderate musculoskeletal symptoms are a risk factor for more severe symptoms, it is important to ensure a good visual environment in occupations involving visually demanding near work.

Quantitative Determination of Isotope Ratios from Experimental Isotopic Distributions

PubMed Central

Kaur, Parminder; O’Connor, Peter B.

2008-01-01

Isotope variability due to natural processes provides important information for studying a variety of complex natural phenomena from the origins of a particular sample to the traces of biochemical reaction mechanisms. These measurements require high-precision determination of isotope ratios of a particular element involved. Isotope Ratio Mass Spectrometers (IRMS) are widely employed tools for such a high-precision analysis, which have some limitations. This work aims at overcoming the limitations inherent to IRMS by estimating the elemental isotopic abundance from the experimental isotopic distribution. In particular, a computational method has been derived which allows the calculation of 13C/12C ratios from the whole isotopic distributions, given certain caveats, and these calculations are applied to several cases to demonstrate their utility. The limitations of the method in terms of the required number of ions and S/N ratio are discussed. For high-precision estimates of the isotope ratios, this method requires very precise measurement of the experimental isotopic distribution abundances, free from any artifacts introduced by noise, sample heterogeneity, or other experimental sources. PMID:17263354

A multiscale-based approach for composite materials with embedded PZT filaments for energy harvesting

NASA Astrophysics Data System (ADS)

El-Etriby, Ahmed E.; Abdel-Meguid, Mohamed E.; Hatem, Tarek M.; Bahei-El-Din, Yehia A.

2014-03-01

Ambient vibrations are major source of wasted energy, exploiting properly such vibration can be converted to valuable energy and harvested to power up devices, i.e. electronic devices. Accordingly, energy harvesting using smart structures with active piezoelectric ceramics has gained wide interest over the past few years as a method for converting such wasted energy. This paper provides numerical and experimental analysis of piezoelectric fiber based composites for energy harvesting applications proposing a multi-scale modeling approach coupled with experimental verification. The multi-scale approach suggested to predict the behavior of piezoelectric fiber-based composites use micromechanical model based on Transformation Field Analysis (TFA) to calculate the overall material properties of electrically active composite structure. Capitalizing on the calculated properties, single-phase analysis of a homogeneous structure is conducted using finite element method. The experimental work approach involves running dynamic tests on piezoelectric fiber-based composites to simulate mechanical vibrations experienced by a subway train floor tiles. Experimental results agree well with the numerical results both for static and dynamic tests.

Get away special the low-cost route to orbit

NASA Technical Reports Server (NTRS)

Prouty, C.

1986-01-01

NASA has established the Get Away Special (GAS) program as a means for providing anyone who wishes the opportunity to place a small self-contained experimental payload aboard a Space Shuttle mission for a very low cost. The GAS program is now well established, and has a respectable history with 53 payloads flown to date. The GAS experimenters are a diverse group who have demonstrated that people from all walks of life, and from many nations, are interested in working in space. This paper traces the history of the program from its concept through the development phase to the present time, and takes a brief look at the future. It also addresses the steps involved in making a payload reservation and the programmatic and technical relationships that are established between NASA and GAS customers.

On heart rate variability and autonomic activity in homeostasis and in systemic inflammation.

PubMed

Scheff, Jeremy D; Griffel, Benjamin; Corbett, Siobhan A; Calvano, Steve E; Androulakis, Ioannis P

2014-06-01

Analysis of heart rate variability (HRV) is a promising diagnostic technique due to the noninvasive nature of the measurements involved and established correlations with disease severity, particularly in inflammation-linked disorders. However, the complexities underlying the interpretation of HRV complicate understanding the mechanisms that cause variability. Despite this, such interpretations are often found in literature. In this paper we explored mathematical modeling of the relationship between the autonomic nervous system and the heart, incorporating basic mechanisms such as perturbing mean values of oscillating autonomic activities and saturating signal transduction pathways to explore their impacts on HRV. We focused our analysis on human endotoxemia, a well-established, controlled experimental model of systemic inflammation that provokes changes in HRV representative of acute stress. By contrasting modeling results with published experimental data and analyses, we found that even a simple model linking the autonomic nervous system and the heart confound the interpretation of HRV changes in human endotoxemia. Multiple plausible alternative hypotheses, encoded in a model-based framework, equally reconciled experimental results. In total, our work illustrates how conventional assumptions about the relationships between autonomic activity and frequency-domain HRV metrics break down, even in a simple model. This underscores the need for further experimental work towards unraveling the underlying mechanisms of autonomic dysfunction and HRV changes in systemic inflammation. Understanding the extent of information encoded in HRV signals is critical in appropriately analyzing prior and future studies. Copyright © 2014 Elsevier Inc. All rights reserved.

On heart rate variability and autonomic activity in homeostasis and in systemic inflammation

PubMed Central

Scheff, Jeremy D.; Griffel, Benjamin; Corbett, Siobhan A.; Calvano, Steve E.; Androulakis, Ioannis P.

2014-01-01

Analysis of heart rate variability (HRV) is a promising diagnostic technique due to the noninvasive nature of the measurements involved and established correlations with disease severity, particularly in inflammation-linked disorders. However, the complexities underlying the interpretation of HRV complicate understanding the mechanisms that cause variability. Despite this, such interpretations are often found in literature. In this paper we explored mathematical modeling of the relationship between the autonomic nervous system and the heart, incorporating basic mechanisms such as perturbing mean values of oscillating autonomic activities and saturating signal transduction pathways to explore their impacts on HRV. We focused our analysis on human endotoxemia, a well-established, controlled experimental model of systemic inflammation that provokes changes in HRV representative of acute stress. By contrasting modeling results with published experimental data and analyses, we found that even a simple model linking the autonomic nervous system and the heart confound the interpretation of HRV changes in human endotoxemia. Multiple plausible alternative hypotheses, encoded in a model-based framework, equally reconciled experimental results. In total, our work illustrates how conventional assumptions about the relationships between autonomic activity and frequency-domain HRV metrics break down, even in a simple model. This underscores the need for further experimental work towards unraveling the underlying mechanisms of autonomic dysfunction and HRV changes in systemic inflammation. Understanding the extent of information encoded in HRV signals is critical in appropriately analyzing prior and future studies. PMID:24680646

Determination of full piezoelectric complex parameters using gradient-based optimization algorithm

NASA Astrophysics Data System (ADS)

Kiyono, C. Y.; Pérez, N.; Silva, E. C. N.

2016-02-01

At present, numerical techniques allow the precise simulation of mechanical structures, but the results are limited by the knowledge of the material properties. In the case of piezoelectric ceramics, the full model determination in the linear range involves five elastic, three piezoelectric, and two dielectric complex parameters. A successful solution to obtaining piezoceramic properties consists of comparing the experimental measurement of the impedance curve and the results of a numerical model by using the finite element method (FEM). In the present work, a new systematic optimization method is proposed to adjust the full piezoelectric complex parameters in the FEM model. Once implemented, the method only requires the experimental data (impedance modulus and phase data acquired by an impedometer), material density, geometry, and initial values for the properties. This method combines a FEM routine implemented using an 8-noded axisymmetric element with a gradient-based optimization routine based on the method of moving asymptotes (MMA). The main objective of the optimization procedure is minimizing the quadratic difference between the experimental and numerical electrical conductance and resistance curves (to consider resonance and antiresonance frequencies). To assure the convergence of the optimization procedure, this work proposes restarting the optimization loop whenever the procedure ends in an undesired or an unfeasible solution. Two experimental examples using PZ27 and APC850 samples are presented to test the precision of the method and to check the dependency of the frequency range used, respectively.

Spatial Variation of Pressure in the Lyophilization Product Chamber Part 1: Computational Modeling.

PubMed

Ganguly, Arnab; Varma, Nikhil; Sane, Pooja; Bogner, Robin; Pikal, Michael; Alexeenko, Alina

2017-04-01

The flow physics in the product chamber of a freeze dryer involves coupled heat and mass transfer at different length and time scales. The low-pressure environment and the relatively small flow velocities make it difficult to quantify the flow structure experimentally. The current work presents the three-dimensional computational fluid dynamics (CFD) modeling for vapor flow in a laboratory scale freeze dryer validated with experimental data and theory. The model accounts for the presence of a non-condensable gas such as nitrogen or air using a continuum multi-species model. The flow structure at different sublimation rates, chamber pressures, and shelf-gaps are systematically investigated. Emphasis has been placed on accurately predicting the pressure variation across the subliming front. At a chamber set pressure of 115 mtorr and a sublimation rate of 1.3 kg/h/m 2 , the pressure variation reaches about 9 mtorr. The pressure variation increased linearly with sublimation rate in the range of 0.5 to 1.3 kg/h/m 2 . The dependence of pressure variation on the shelf-gap was also studied both computationally and experimentally. The CFD modeling results are found to agree within 10% with the experimental measurements. The computational model was also compared to analytical solution valid for small shelf-gaps. Thus, the current work presents validation study motivating broader use of CFD in optimizing freeze-drying process and equipment design.

Computational Nanophotonics: modeling optical interactions and transport in tailored nanosystem architectures

DOE Office of Scientific and Technical Information (OSTI.GOV)

Schatz, George; Ratner, Mark

2014-02-27

This report describes research by George Schatz and Mark Ratner that was done over the period 10/03-5/09 at Northwestern University. This research project was part of a larger research project with the same title led by Stephen Gray at Argonne. A significant amount of our work involved collaborations with Gray, and there were many joint publications as summarized later. In addition, a lot of this work involved collaborations with experimental groups at Northwestern, Argonne, and elsewhere. The research was primarily concerned with developing theory and computational methods that can be used to describe the interaction of light with noble metalmore » nanoparticles (especially silver) that are capable of plasmon excitation. Classical electrodynamics provides a powerful approach for performing these studies, so much of this research project involved the development of methods for solving Maxwell’s equations, including both linear and nonlinear effects, and examining a wide range of nanostructures, including particles, particle arrays, metal films, films with holes, and combinations of metal nanostructures with polymers and other dielectrics. In addition, our work broke new ground in the development of quantum mechanical methods to describe plasmonic effects based on the use of time dependent density functional theory, and we developed new theory concerned with the coupling of plasmons to electrical transport in molecular wire structures. Applications of our technology were aimed at the development of plasmonic devices as components of optoelectronic circuits, plasmons for spectroscopy applications, and plasmons for energy-related applications.« less

Using a Large-scale Neural Model of Cortical Object Processing to Investigate the Neural Substrate for Managing Multiple Items in Short-term Memory.

PubMed

Liu, Qin; Ulloa, Antonio; Horwitz, Barry

2017-11-01

Many cognitive and computational models have been proposed to help understand working memory. In this article, we present a simulation study of cortical processing of visual objects during several working memory tasks using an extended version of a previously constructed large-scale neural model [Tagamets, M. A., & Horwitz, B. Integrating electrophysiological and anatomical experimental data to create a large-scale model that simulates a delayed match-to-sample human brain imaging study. Cerebral Cortex, 8, 310-320, 1998]. The original model consisted of arrays of Wilson-Cowan type of neuronal populations representing primary and secondary visual cortices, inferotemporal (IT) cortex, and pFC. We added a module representing entorhinal cortex, which functions as a gating module. We successfully implemented multiple working memory tasks using the same model and produced neuronal patterns in visual cortex, IT cortex, and pFC that match experimental findings. These working memory tasks can include distractor stimuli or can require that multiple items be retained in mind during a delay period (Sternberg's task). Besides electrophysiology data and behavioral data, we also generated fMRI BOLD time series from our simulation. Our results support the involvement of IT cortex in working memory maintenance and suggest the cortical architecture underlying the neural mechanisms mediating particular working memory tasks. Furthermore, we noticed that, during simulations of memorizing a list of objects, the first and last items in the sequence were recalled best, which may implicate the neural mechanism behind this important psychological effect (i.e., the primacy and recency effect).

Comparative Investigation on Tool Wear during End Milling of AISI H13 Steel with Different Tool Path Strategies

NASA Astrophysics Data System (ADS)

Adesta, Erry Yulian T.; Riza, Muhammad; Avicena

2018-03-01

Tool wear prediction plays a significant role in machining industry for proper planning and control machining parameters and optimization of cutting conditions. This paper aims to investigate the effect of tool path strategies that are contour-in and zigzag tool path strategies applied on tool wear during pocket milling process. The experiments were carried out on CNC vertical machining centre by involving PVD coated carbide inserts. Cutting speed, feed rate and depth of cut were set to vary. In an experiment with three factors at three levels, Response Surface Method (RSM) design of experiment with a standard called Central Composite Design (CCD) was employed. Results obtained indicate that tool wear increases significantly at higher range of feed per tooth compared to cutting speed and depth of cut. This result of this experimental work is then proven statistically by developing empirical model. The prediction model for the response variable of tool wear for contour-in strategy developed in this research shows a good agreement with experimental work.

Femtosecond laser irradiation on Nd:YAG crystal: Surface ablation and high-spatial-frequency nanograting

NASA Astrophysics Data System (ADS)

Ren, Yingying; Zhang, Limu; Romero, Carolina; Vázquez de Aldana, Javier R.; Chen, Feng

2018-05-01

In this work, we systematically study the surface modifications of femtosecond (fs) laser irradiated Nd:YAG crystal in stationary focusing case (i.e., the beam focused on the target in the steady focusing geometry) or dynamic scanning case (i.e., focused fs-laser beam scanning over the target material). Micro-sized structures (e.g. micro-craters or lines) are experimentally produced in a large scale of parameters in terms of pulse energy as well as (effective) pulse number. Surface ablation of Nd:YAG surface under both processing cases are investigated, involving the morphological evolution, parameter dependence, the ablation threshold fluences and the incubation factors. Meanwhile, under specific irradiation conditions, periodic surface structures with high-spatial-frequency (<λ/2) can be generated. The obtained period is as short as 157 nm in this work. Investigations on the evolution of nanograting formation and fluence dependence of period are performed. The experimental results obtained under different cases and the comparison between them reveal that incubation effect plays an important role not only in the ablation of Nd:YAG surface but also in the processes of nanograting formation.

Containment system for experiments on radioactive and other hazardous materials in a Paris-Edinburgh press

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jacobsen, M. K., E-mail: mjacobsen@lanl.gov; Velisavljevic, N.

2015-11-15

Recent technical developments using the large volume Paris-Edinburgh press platform have enabled x-ray synchrotron studies at high pressure and temperature conditions. However, its application to some materials of interest, such as high hazard materials that require special handling due to safety issues, reactivity, or other challenges, has not been feasible without the introduction of special containment systems to eliminate the hazards. However, introduction of a containment system is challenging due to the requirement to provide full safety containment for operation in the variety of environments available, while not hindering any of the experimental probes that are available for inert samplemore » measurement. In this work, we report on the development and implementation of a full safety enclosure for a Paris-Edinburgh type press. During the initial development and subsequent application stage of work, experiments were performed on both cerium dioxide (CeO{sub 2}) and uranium (U). This device allows for full implementation of all currently available experimental probes involving the Paris-Edinburgh press at the High Pressure Collaborative Access Team sector of the Advanced Photon Source.« less

Analysis of Residual Acceleration Effects on Transport and Segregation During Directional Solidification of Tin-Bismuth in the MEPHISTO Furnace Facility

NASA Technical Reports Server (NTRS)

Alexander, J. Iwan D.; Lizee, Arnaud

1996-01-01

The object of this work, started in March of 1995, is to approach the problem of determining the transport conditions (and effects of residual acceleration) during the plane-front directional solidification of a tin-bismuth alloy under low gravity conditions. The work involves using a combination of 2- and 3-D numerical models, scaling analyses, 1-D models and the results of ground-based and low-gravity experiments. The experiments conducted in the MEPHISTO furnace facility during the USMP-3 spaceflight which took place earlier this year (22 Feb. - 6 Mar. 1996). This experiment represents an unprecedented opportunity to make a quantitative correlation between residual accelerations and the response of an actual experimental solidification system

Traveling waves for the mass in mass model of granular chains

DOE PAGES

Kevrekidis, Panayotis G.; Stefanov, Atanas G.; Xu, Haitao

2016-06-03

In this work, we consider the mass in mass (or mass with mass) system of granular chains, namely, a granular chain involving additionally an internal (or, respectively, external) resonator. For these chains, we rigorously establish that under suitable “anti-resonance” conditions connecting the mass of the resonator and the speed of the wave, bell-shaped traveling-wave solutions continue to exist in the system, in a way reminiscent of the results proven for the standard granular chain of elastic Hertzian contacts. Finally, we also numerically touch upon settings, where the conditions do not hold, illustrating, in line also with recent experimental work, thatmore » non-monotonic waves bearing non-vanishing tails may exist in the latter case.« less

Numerical Investigations of High Pressure Acoustic Waves in Resonators

NASA Technical Reports Server (NTRS)

Athavale, Mahesh; Pindera, Maciej; Daniels, Christopher C.; Steinetz, Bruce M.

2004-01-01

This presentation presents work on numerical investigations of nonlinear acoustic phenomena in resonators that can generate high-pressure waves using acoustic forcing of the flow. Time-accurate simulations of the flow in a closed cone resonator were performed at different oscillation frequencies and amplitudes, and the numerical results for the resonance frequency and fluid pressure increase match the GRC experimental data well. Work on cone resonator assembly simulations has started and will involve calculations of the flow through the resonator assembly with and without acoustic excitation. A new technique for direct calculation of resonance frequency of complex shaped resonators is also being investigated. Script-driven command procedures will also be developed for optimization of the resonator shape for maximum pressure increase.

Molybdenum disulfide and water interaction parameters

NASA Astrophysics Data System (ADS)

Heiranian, Mohammad; Wu, Yanbin; Aluru, Narayana R.

2017-09-01

Understanding the interaction between water and molybdenum disulfide (MoS2) is of crucial importance to investigate the physics of various applications involving MoS2 and water interfaces. An accurate force field is required to describe water and MoS2 interactions. In this work, water-MoS2 force field parameters are derived using the high-accuracy random phase approximation (RPA) method and validated by comparing to experiments. The parameters obtained from the RPA method result in water-MoS2 interface properties (solid-liquid work of adhesion) in good comparison to the experimental measurements. An accurate description of MoS2-water interaction will facilitate the study of MoS2 in applications such as DNA sequencing, sea water desalination, and power generation.

Traveling waves for the mass in mass model of granular chains

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kevrekidis, Panayotis G.; Stefanov, Atanas G.; Xu, Haitao

In this work, we consider the mass in mass (or mass with mass) system of granular chains, namely, a granular chain involving additionally an internal (or, respectively, external) resonator. For these chains, we rigorously establish that under suitable “anti-resonance” conditions connecting the mass of the resonator and the speed of the wave, bell-shaped traveling-wave solutions continue to exist in the system, in a way reminiscent of the results proven for the standard granular chain of elastic Hertzian contacts. Finally, we also numerically touch upon settings, where the conditions do not hold, illustrating, in line also with recent experimental work, thatmore » non-monotonic waves bearing non-vanishing tails may exist in the latter case.« less

Microglial activation and the nitric oxide/cGMP/PKG pathway underlie enhanced neuronal vulnerability to mitochondrial dysfunction in experimental multiple sclerosis.

PubMed

Mancini, Andrea; Tantucci, Michela; Mazzocchetti, Petra; de Iure, Antonio; Durante, Valentina; Macchioni, Lara; Giampà, Carmela; Alvino, Alessandra; Gaetani, Lorenzo; Costa, Cinzia; Tozzi, Alessandro; Calabresi, Paolo; Di Filippo, Massimiliano

2018-05-01

During multiple sclerosis (MS), a close link has been demonstrated to occur between inflammation and neuro-axonal degeneration, leading to the hypothesis that immune mechanisms may promote neurodegeneration, leading to irreversible disease progression. Energy deficits and inflammation-driven mitochondrial dysfunction seem to be involved in this process. In this work we investigated, by the use of striatal electrophysiological field-potential recordings, if the inflammatory process associated with experimental autoimmune encephalomyelitis (EAE) is able to influence neuronal vulnerability to the blockade of mitochondrial complex IV, a crucial component for mitochondrial activity responsible of about 90% of total cellular oxygen consumption. We showed that during the acute relapsing phase of EAE, neuronal susceptibility to mitochondrial complex IV inhibition is markedly enhanced. This detrimental effect was counteracted by the pharmacological inhibition of microglia, of nitric oxide (NO) synthesis and its intracellular pathway (involving soluble guanylyl cyclase, sGC, and protein kinase G, PKG). The obtained results suggest that mitochondrial complex IV exerts an important role in maintaining neuronal energetic homeostasis during EAE. The pathological processes associated with experimental MS, and in particular the activation of microglia and of the NO pathway, lead to an increased neuronal vulnerability to mitochondrial complex IV inhibition, representing promising pharmacological targets. Copyright © 2018 Elsevier Inc. All rights reserved.

Interdisciplinary Learning Through the Teaching of Science and Art

NASA Astrophysics Data System (ADS)

Illingworth, Samuel; Verran, Joanna; Griffiths, Dave; Carpenter, Annie

2017-04-01

Science and Art are two disciplines that are usually treated as mutually exclusive entities, and yet which have much to offer each other in terms of process, experimentation and analysis. The field of SciArt (or ArtSci) is a relatively new one, in which scientists and artists work together to create information and demonstrations that are neither the science of art nor the art of science but are instead interdisciplinary investigations that utilise the unique strengths and overlapping commonalities of both fields. As well as the products and processes that are created via such collaboration, the introduction of artists and scientists to one another is an exceptionally valuable prospect which can have a significant impact on the working practices of both sets of collaborators. To further develop this field and these opportunities for collaboration, it is necessary to introduce scientists and artists to the potential of working together at an early point in their careers, ideally when they are still in tertiary education. Manchester Metropolitan University has been involved in several art and science programmes that involve science and art undergraduate and postgraduate students working together to create performances, experiments and demonstrations. This includes the UK's first dedicated SciArt course, residential field trips, and exhibiting at an internationally- renowned gallery. Here we present the outcomes of this work, discussing the development of these schemes and presenting future opportunities for early career scientists and artists to collaborate further.

Modelling neural correlates of working memory: A coordinate-based meta-analysis

PubMed Central

Rottschy, C.; Langner, R.; Dogan, I.; Reetz, K.; Laird, A.R.; Schulz, J.B.; Fox, P.T.; Eickhoff, S.B.

2011-01-01

Working memory subsumes the capability to memorize, retrieve and utilize information for a limited period of time which is essential to many human behaviours. Moreover, impairments of working memory functions may be found in nearly all neurological and psychiatric diseases. To examine what brain regions are commonly and differently active during various working memory tasks, we performed a coordinate-based meta-analysis over 189 fMRI experiments on healthy subjects. The main effect yielded a widespread bilateral fronto-parietal network. Further meta-analyses revealed that several regions were sensitive to specific task components, e.g. Broca’s region was selectively active during verbal tasks or ventral and dorsal premotor cortex were preferentially involved in memory for object identity and location, respectively. Moreover, the lateral prefrontal cortex showed a division in a rostral and a caudal part based on differential involvement in task-set and load effects. Nevertheless, a consistent but more restricted “core” network emerged from conjunctions across analyses of specific task designs and contrasts. This “core” network appears to comprise the quintessence of regions, which are necessary during working memory tasks. It may be argued that the core regions form a distributed executive network with potentially generalized functions for focusing on competing representations in the brain. The present study demonstrates that meta-analyses are a powerful tool to integrate the data of functional imaging studies on a (broader) psychological construct, probing the consistency across various paradigms as well as the differential effects of different experimental implementations. PMID:22178808

Computational investigation of kinetics of cross-linking reactions in proteins: importance in structure prediction.

PubMed

Bandyopadhyay, Pradipta; Kuntz, Irwin D

2009-01-01

The determination of protein structure using distance constraints is a new and promising field of study. One implementation involves attaching residues of a protein using a cross-linking agent, followed by protease digestion, analysis of the resulting peptides by mass spectroscopy, and finally sequence threading to detect the protein folds. In the present work, we carry out computational modeling of the kinetics of cross-linking reactions in proteins using the master equation approach. The rate constants of the cross-linking reactions are estimated using the pKas and the solvent-accessible surface areas of the residues involved. This model is tested with fibroblast growth factor (FGF) and cytochrome C. It is consistent with the initial experimental rate data for individual lysine residues for cytochrome C. Our model captures all observed cross-links for FGF and almost 90% of the observed cross-links for cytochrome C, although it also predicts cross-links that were not observed experimentally (false positives). However, the analysis of the false positive results is complicated by the fact that experimental detection of cross-links can be difficult and may depend on specific experimental conditions such as pH, ionic strength. Receiver operator characteristic plots showed that our model does a good job in predicting the observed cross-links. Molecular dynamics simulations showed that for cytochrome C, in general, the two lysines come closer for the observed cross-links as compared to the false positive ones. For FGF, no such clear pattern exists. The kinetic model and MD simulation can be used to study proposed cross-linking protocols.

Optimizing LX-17 Thermal Decomposition Model Parameters with Evolutionary Algorithms

NASA Astrophysics Data System (ADS)

Moore, Jason; McClelland, Matthew; Tarver, Craig; Hsu, Peter; Springer, H. Keo

2017-06-01

We investigate and model the cook-off behavior of LX-17 because this knowledge is critical to understanding system response in abnormal thermal environments. Thermal decomposition of LX-17 has been explored in conventional ODTX (One-Dimensional Time-to-eXplosion), PODTX (ODTX with pressure-measurement), TGA (thermogravimetric analysis), and DSC (differential scanning calorimetry) experiments using varied temperature profiles. These experimental data are the basis for developing multiple reaction schemes with coupled mechanics in LLNL's multi-physics hydrocode, ALE3D (Arbitrary Lagrangian-Eulerian code in 2D and 3D). We employ evolutionary algorithms to optimize reaction rate parameters on high performance computing clusters. Once experimentally validated, this model will be scalable to a number of applications involving LX-17 and can be used to develop more sophisticated experimental methods. Furthermore, the optimization methodology developed herein should be applicable to other high explosive materials. This work was performed under the auspices of the U.S. DOE by LLNL under contract DE-AC52-07NA27344. LLNS, LLC.

Stochastic simulations of fatty-acid proto-cell models

NASA Astrophysics Data System (ADS)

Mavelli, F.; Ruiz-Mirazo, K.

2007-06-01

In this contribution we tackle the problem of simulating the time behavior of self-assembling fatty acid vesicles in different experimental conditions. These systems have been (and are being) explored by various labs as possible precursor models of cellular compartments. By means of our recently developed stochastic simulation platform ('ENVIRONMENT') we are able to reproduce quite satisfactorily experimental data that have been reported on the different growth behavior of this type of proto-cellular systems, depending on the level of osmotic pressure they are under. The work here presented is part of a more general attempt to gain insight into the problem of how self-assembling vesicles (closed bilayer structures) could progressively turn into minimal self-producing and self-reproducing cells: i.e., into interesting candidates for (proto-)biological systems. This involves crossing the traditional gap between in silico and in vitro approaches, as we try to do here, convinced that major adavances in the field require the correct integration of both theoretical and experimental endeavors.

Stamp forming optimization for formability and crystallinity

NASA Astrophysics Data System (ADS)

Donderwinkel, T. G.; Rietman, B.; Haanappel, S. P.; Akkerman, R.

2016-10-01

The stamp forming process is well suited for high volume production of thermoplastic composite parts. The process can be characterized as highly non-isothermal as it involves local quench-cooling of a molten thermoplastic composite blank where it makes contact with colder tooling. The formability of the thermoplastic composite depends on the viscoelastic material behavior of the matrix material, which is sensitive to temperature and degree of crystallinity. An experimental study was performed to determine the effect of temperature and crystallinity on the storage modulus during cooling for a woven glass fiber polyamide-6 composite material. An increase of two decades in modulus was observed during crystallization. As this will significantly impede the blank formability, the onset of crystallization effectively governs the time available for forming. Besides the experimental work, a numerical model is developed to study the temperature and crystallinity throughout the stamp forming process. A process window can be determined by feeding the model with the experimentally obtained data on crystallization.

Structural model of the hUbA1-UbcH10 quaternary complex: in silico and experimental analysis of the protein-protein interactions between E1, E2 and ubiquitin.

PubMed

Correale, Stefania; de Paola, Ivan; Morgillo, Carmine Marco; Federico, Antonella; Zaccaro, Laura; Pallante, Pierlorenzo; Galeone, Aldo; Fusco, Alfredo; Pedone, Emilia; Luque, F Javier; Catalanotti, Bruno

2014-01-01

UbcH10 is a component of the Ubiquitin Conjugation Enzymes (Ubc; E2) involved in the ubiquitination cascade controlling the cell cycle progression, whereby ubiquitin, activated by E1, is transferred through E2 to the target protein with the involvement of E3 enzymes. In this work we propose the first three dimensional model of the tetrameric complex formed by the human UbA1 (E1), two ubiquitin molecules and UbcH10 (E2), leading to the transthiolation reaction. The 3D model was built up by using an experimentally guided incremental docking strategy that combined homology modeling, protein-protein docking and refinement by means of molecular dynamics simulations. The structural features of the in silico model allowed us to identify the regions that mediate the recognition between the interacting proteins, revealing the active role of the ubiquitin crosslinked to E1 in the complex formation. Finally, the role of these regions involved in the E1-E2 binding was validated by designing short peptides that specifically interfere with the binding of UbcH10, thus supporting the reliability of the proposed model and representing valuable scaffolds for the design of peptidomimetic compounds that can bind selectively to Ubcs and inhibit the ubiquitylation process in pathological disorders.

An overview of the nonequilibrium behavior of polymer glasses

NASA Technical Reports Server (NTRS)

Tant, M. R.; Wilkes, G. L.

1981-01-01

It is pointed out that research efforts are at present being directed in two areas, one comprising experimental studies of this phenomenon in various glassy polymer systems and the other involving the development of a quantitative theory capable of satisfactorily predicting aging behavior for a variety of polymer materials under different conditions. Recent work in both these areas is surveyed. The basic principles of nonequilibrium behavior are outlined, with emphasis placed on changes in material properties with annealing below the glass transition temperature. Free volume theory and thermodynamic theory are discussed.

Applications of mass spectrometry techniques to autoclave curing of materials

NASA Technical Reports Server (NTRS)

Smith, A. C.

1983-01-01

Mass spectrometer analysis of gases evolved from polymer materials during a cure cycle can provide a wealth of information useful for studying cure properties and procedures. In this paper data is presented for two materials to support the feasibility of using mass spectrometer gas analysis techniques to enhance the knowledge of autoclave curing of composite materials and provide additional information for process control evaluation. It is expected that this technique will also be useful in working out the details involved in determining the proper cure cycle for new or experimental materials.

Visualization experiments on steam injection in Hele-Shaw cells

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kong, Xianli; Haghighi, M.; Yortsos, Y.C.

1992-03-01

Flow visualization experiments have been successfully employed in reservoir engineering research for many years. They involve 2-D geometries in transparent Hele-Shaw cells and glass micromodels. Although much work has been done on immiscible flows (drainage or imbibition), visualization of steamfloods, which constitute a major part of current EOR methods, has not been attempted to data. In this paper, we present experimental results on steam injection in a transparent, pyrex glass Hele-Shaw cell. Both synthetic (Dutrex 739) and natural heavy oils were used under a variety of conditions, including effects of gravity.

Polymorphism at the REF(2)P Locus in DROSOPHILA MELANOGASTER: Preliminary Experiments concerning the Selection Mechanisms Involved in Its Maintenance

PubMed Central

Fleuriet, Annie

1981-01-01

It has been shown previously that a polymorphism for two alleles of the ref(2)P locus is a regular feature of French natural populations of Drosophila melanogaster and that this is maintained in laboratory populations raised in cages. In this paper, an experimental population and egg-collection experiments are reported. Differential survival of the three genotypes would be the main factor leading to the equilibrium frequencies, working only in drastic conditions of larval competition. PMID:6791986

Collective gradient sensing and chemotaxis: modeling and recent developments

NASA Astrophysics Data System (ADS)

Camley, Brian A.

2018-06-01

Cells measure a vast variety of signals, from their environment’s stiffness to chemical concentrations and gradients; physical principles strongly limit how accurately they can do this. However, when many cells work together, they can cooperate to exceed the accuracy of any single cell. In this topical review, I will discuss the experimental evidence showing that cells collectively sense gradients of many signal types, and the models and physical principles involved. I also propose new routes by which experiments and theory can expand our understanding of these problems.

Vortex rope instabilities in a model of conical draft tube

NASA Astrophysics Data System (ADS)

Skripkin, Sergey; Tsoy, Mikhail; Kuibin, Pavel; Shtork, Sergey

2017-10-01

We report on experimental studies of the formation of vortex ropes in a laboratory simplified model of hydroturbine draft tube. Work is focused on the observation of various flow patterns at the different rotational speed of turbine runner at fixed flow rate. The measurements involve high-speed visualization and pressure pulsations recordings. Draft tube wall pressure pulsations are registered by pressure transducer for different flow regimes. Vortex rope precession frequency were calculated using FFT transform. The experiments showed interesting features of precessing vortex rope like twin spiral and formation of vortex ring.

A building block for hardware belief networks.

PubMed

Behin-Aein, Behtash; Diep, Vinh; Datta, Supriyo

2016-07-21

Belief networks represent a powerful approach to problems involving probabilistic inference, but much of the work in this area is software based utilizing standard deterministic hardware based on the transistor which provides the gain and directionality needed to interconnect billions of them into useful networks. This paper proposes a transistor like device that could provide an analogous building block for probabilistic networks. We present two proof-of-concept examples of belief networks, one reciprocal and one non-reciprocal, implemented using the proposed device which is simulated using experimentally benchmarked models.

Comment on 'Realism and quantum flux tunneling'

NASA Technical Reports Server (NTRS)

Leggett, A. J.; Garg, Anupam

1987-01-01

A reply is presented to Ballentine's (1987) critique of the Legett and Garg (1985) experiment to discriminate between the experimental predictions of quantum mechanics (QM) and those of a class of macrorealistic theories. Legett and Garg uphold their earlier conclusions on the basis of the fact that the present critique refers to an experiment which was not in fact proposed. It is stressed that the original work involved an analysis according to macrorealism, while the calculations of Ballentine only demonstrate the internal consistency of the formalism of QM when applied to three consecutive actually performed experiments.

Prediction of gas-liquid two-phase flow regime in microgravity

NASA Technical Reports Server (NTRS)

Lee, Jinho; Platt, Jonathan A.

1993-01-01

An attempt is made to predict gas-liquid two-phase flow regime in a pipe in a microgravity environment through scaling analysis based on dominant physical mechanisms. Simple inlet geometry is adopted in the analysis to see the effect of inlet configuration on flow regime transitions. Comparison of the prediction with the existing experimental data shows good agreement, though more work is required to better define some physical parameters. The analysis clarifies much of the physics involved in this problem and can be applied to other configurations.

GRIPs (Group Investigation Problems) for Introductory Physics

NASA Astrophysics Data System (ADS)

Moore, Thomas A.

2006-12-01

GRIPs lie somewhere between homework problems and simple labs: they are open-ended questions that require a mixture of problem-solving skills and hands-on experimentation to solve practical puzzles involving simple physical objects. In this talk, I will describe three GRIPs that I developed for a first-semester introductory calculus-based physics course based on the "Six Ideas That Shaped Physics" text. I will discuss the design of the three GRIPs we used this past fall, our experience in working with students on these problems, and students' response as reported on course evaluations.

Glenn Heat Transfer Simulation and Solver Graphical User Interface: Development and Testing

NASA Technical Reports Server (NTRS)

Kardamis, Joseph R.

2004-01-01

In the Tui ine Branch of the Turbomachinery and Propulsion Systems Division, researching and developing efficient turbine aerothermodynamics technologies is the main objective. Creating effective turbines for jet engines is a process which, if based purely on physical experimental testing, would be extremely expensive. It is for this reason, and also for the reasons of speed and ease, that the Turbine Branch spends a large amount of effort working with simulations of turbines. Specifically, they focus their work on two main fields: Computational Field Dynamics (CFD), and Experimental data analysis. The experimental field involves comparing experimental results to simulated results, whereas the CFD field involves running these simulations. The simulations are applied to aerodynamics and heat transfer cases, for both steady and unsteady flow conditions. By and large this work is applied to the domain of flow and heat transfer in axial turbines. The main application used to run these heat flow simulations is GlennHT. This program, recently rewritten in FORTRAN 90, allows the user to input a job file which specifies all the necessary parameters needed to simulate flow through a user-defined grid. There are several other executables used as well, ranging in application from converting grid files to and from particular formats, to merging blocks in a connectivity file, to converting connectivity files to a GlennHT compatible format. All of these executables are run from the command line in a terminal; some of them have interactive prompts where the user must specify the files to be manipulated after the program starts, while others take all of their parameters from the command line. With this amount of variation comes a good deal of commands and formats to memorize, which can cause slower and less efficient work, as users may forget how to execute a certain program, or not remember the pathnames of the files they wish to use. Two years ago, steps were made to expedite this process with a graphical user interface (GUI) that combines the functionality of all the executables along with adding some new functionality, such as residuals graphing and boundary conditions creation. Upon my beginning here at Glenn, many parts of the GUI, which was developed in Java, were nonfunctional. There were also issues with cross-platforming, as systems in the branch were transitioning from Silicon Graphics (SGI) machines to Linux machines. My goals this summer are to finish the parts of the GUI that are not yet completed, fix parts that did not work correctly, expand the functionality to include other useful features, such as grid surface highlighting, and make the system compatible with both Linux and SGI. I will also be heavily testing the system and providing sufficient documentation on how to use the GUI, as no such documentation existed previously.

Measuring and Advancing Experimental Design Ability in an Introductory Course without Altering Existing Lab Curriculum†

PubMed Central

Shanks, Ryan A.; Robertson, Chuck L.; Haygood, Christian S.; Herdliksa, Anna M.; Herdliska, Heather R.; Lloyd, Steven A.

2017-01-01

Introductory biology courses provide an important opportunity to prepare students for future courses, yet existing cookbook labs, although important in their own way, fail to provide many of the advantages of semester-long research experiences. Engaging, authentic research experiences aid biology students in meeting many learning goals. Therefore, overlaying a research experience onto the existing lab structure allows faculty to overcome barriers involving curricular change. Here we propose a working model for this overlay design in an introductory biology course and detail a means to conduct this lab with minimal increases in student and faculty workloads. Furthermore, we conducted exploratory factor analysis of the Experimental Design Ability Test (EDAT) and uncovered two latent factors which provide valid means to assess this overlay model’s ability to increase advanced experimental design abilities. In a pre-test/post-test design, we demonstrate significant increases in both basic and advanced experimental design abilities in an experimental and comparison group. We measured significantly higher gains in advanced experimental design understanding in students in the experimental group. We believe this overlay model and EDAT factor analysis contribute a novel means to conduct and assess the effectiveness of authentic research experiences in an introductory course without major changes to the course curriculum and with minimal increases in faculty and student workloads. PMID:28904647

16 CFR § 1702.10 - Human experimental data involving the testing of human subjects.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 16 Commercial Practices 2 2013-01-01 2013-01-01 false Human experimental data involving the testing of human subjects. § 1702.10 Section § 1702.10 Commercial Practices CONSUMER PRODUCT SAFETY... PREVENTION PACKAGING ACT REQUIREMENTS; PETITION PROCEDURES AND REQUIREMENTS § 1702.10 Human experimental data...

Development of Methods to Predict the Effects of Test Media in Ground-Based Propulsion Testing

NASA Technical Reports Server (NTRS)

Drummond, J. Philip; Danehy, Paul M.; Gaffney, Richard L., Jr.; Parker, Peter A.; Tedder, Sarah A.; Chelliah, Harsha K.; Cutler, Andrew D.; Bivolaru, Daniel; Givi, Peyman; Hassan, Hassan A.

2009-01-01

This report discusses work that began in mid-2004 sponsored by the Office of the Secretary of Defense (OSD) Test & Evaluation/Science & Technology (T&E/S&T) Program. The work was undertaken to improve the state of the art of CFD capabilities for predicting the effects of the test media on the flameholding characteristics in scramjet engines. The program had several components including the development of advanced algorithms and models for simulating engine flowpaths as well as a fundamental experimental and diagnostic development effort to support the formulation and validation of the mathematical models. This report provides details of the completed work, involving the development of phenomenological models for Reynolds averaged Navier-Stokes codes, large-eddy simulation techniques and reduced-kinetics models. Experiments that provided data for the modeling efforts are also described, along with with the associated nonintrusive diagnostics used to collect the data.

Predicting the Effects of Test Media in Ground-Based Propulsion Testing

NASA Technical Reports Server (NTRS)

Drummond, J. Philip; Danehy, Paul M.; Bivolaru, Daniel; Gaffney, Richard L.; Parker, Peter A.; Chelliah, Harsha K.; Cutler, Andrew D.; Givi, Peyman; Hassan, Hassan, A.

2006-01-01

This paper discusses the progress of work which began in mid-2004 sponsored by the Office of the Secretary of Defense (OSD) Test & Evaluation/Science & Technology (T&E/S&T) Program. The purpose of the work is to improve the state of the art of CFD capabilities for predicting the effects of the test media on the flameholding characteristics in scramjet engines. The program has several components including the development of advance algorithms and models for simulating engine flowpaths as well as a fundamental experimental and diagnostic development effort to support the formulation and validation of the mathematical models. The paper will provide details of current work involving the development of phenomenological models for Reynolds averaged Navier-Stokes codes, large-eddy simulation techniques and reduced-kinetics models. Experiments that will provide data for the modeling efforts will also be described, along with with the associated nonintrusive diagnostics used to collect the data.

Stress, Psychosocial Mediators, and Cognitive Mediators in Parents of Child Cancer Patients and Cancer Survivors: Attention and Working Memory Pathway Perspectives.

PubMed

Vander Haegen, Marie; Luminet, Olivier

2015-01-01

This review examines stress and its consequences on attention and working memory, stress symptoms in parents of child cancer patients and survivors and long-term consequences of stress on cognitive processing in parents of child cancer survivors. Eligible studies were experimental, meta-analyses, and qualitative (2000-2013) from Pubmed, Medline, the Cochrane Library, PsycArticles, and Google Scholar. We identified 92 eligible papers. They showed that elevated stress can impede performances on tasks requiring attention and memory patterns. In pediatric oncology, parental stress increased shortly after diagnosis involving depression and anxiety. Consequences of stress on cognitive performances were observed mainly among depressed individuals. As regards parents of child cancer survivors, female gender, low Socioeconomic Status (SES), and innate traits of anxiety/anger predicted the development of PTSS. Evidence of stress on attention and working memory processes in parents of child cancer survivors is insufficiently developed.

(Experimental studies of elementary particle interactions at high energies)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Khuri, N.N.

1990-01-01

This report includes descriptions of the combined work of both Tasks B and B{sub 1} at Rockefeller University. Some highlights are worth stressing in this brief introduction. First, one should note the active involvement of two members of our group, Ren and Callaway, in understanding the problem of superconductivity, both high and low {Tc}. This reflects the broad reach of many, but perhaps not all, particle physicists. Second, spurred by the Rockefeller environment, some in our group are also looking at problems in biology. As for our main purpose, I would like to single out the results of Sanda andmore » Morozumi on the {Delta}I = {1/2} rule, the work of Bitar, Ren and myself on a new approach to the path integral, S.Y. Pi's results on Chern-Simons non-relativistic quantum mechanics, and finally the work by Lee and collaborators on the origin of Fermion masses and mixing.« less

Predicting gene regulatory networks by combining spatial and temporal gene expression data in Arabidopsis root stem cells

PubMed Central

de Luis Balaguer, Maria Angels; Fisher, Adam P.; Clark, Natalie M.; Fernandez-Espinosa, Maria Guadalupe; Möller, Barbara K.; Weijers, Dolf; Williams, Cranos; Lorenzo, Oscar; Sozzani, Rosangela

2017-01-01

Identifying the transcription factors (TFs) and associated networks involved in stem cell regulation is essential for understanding the initiation and growth of plant tissues and organs. Although many TFs have been shown to have a role in the Arabidopsis root stem cells, a comprehensive view of the transcriptional signature of the stem cells is lacking. In this work, we used spatial and temporal transcriptomic data to predict interactions among the genes involved in stem cell regulation. To accomplish this, we transcriptionally profiled several stem cell populations and developed a gene regulatory network inference algorithm that combines clustering with dynamic Bayesian network inference. We leveraged the topology of our networks to infer potential major regulators. Specifically, through mathematical modeling and experimental validation, we identified PERIANTHIA (PAN) as an important molecular regulator of quiescent center function. The results presented in this work show that our combination of molecular biology, computational biology, and mathematical modeling is an efficient approach to identify candidate factors that function in the stem cells. PMID:28827319

Requirement Generation for Space Infrastructure Systems

NASA Astrophysics Data System (ADS)

Hempsell, M.

Despite heavy investment, in the half-century period between 1970 and 2020 there will almost no progress in the capability provided by the space infrastructure. It is argued that this is due to a failure during the requirement generation phase of the infrastructure's elements, a failure that is primarily due to following the accepted good practice of involving stakeholders while establishing a mission based set of technical requirements. This argument is supported by both a consideration of the history of the requirement generation phase of past space infrastructure projects, in particular the Space Shuttle, and an analysis of the interactions of the stakeholders during this phase. Traditional stakeholder involvement only works well in mature infrastructures where investment aims to make minor improvements, whereas space activity is still in the early experimental stages and is open to major new initiatives that aim to radically change the way we work in space. A new approach to requirement generation is proposed, which is more appropriate to these current circumstances. This uses a methodology centred on the basic functions the system is intended to perform rather than its expected missions.

Limitations in electrophysiological model development and validation caused by differences between simulations and experimental protocols.

PubMed

Carro, Jesús; Rodríguez-Matas, José F; Monasterio, Violeta; Pueyo, Esther

2017-10-01

Models of ion channel dynamics are usually built by fitting isolated cell experimental values of individual parameters while neglecting the interaction between them. Another shortcoming regards the estimation of ionic current conductances, which is often based on quantification of Action Potential (AP)-derived markers. Although this procedure reduces the uncertainty in the calculation of conductances, many studies evaluate electrophysiological AP-derived markers from single cell simulations, whereas experimental measurements are obtained from tissue preparations. In this work, we explore the limitations of these approaches to estimate ion channel dynamics and maximum current conductances and how they could be overcome by using multiscale simulations of experimental protocols. Four human ventricular cell models, namely ten Tusscher and Panfilov (2006), Grandi et al. (2010), O'Hara et al. (2011), and Carro et al. (2011), were used. Two problems involving scales from ion channels to tissue were investigated: 1) characterization of L-type calcium voltage-dependent inactivation I Ca,L ; 2) identification of major ionic conductance contributors to steady-state AP markers, including APD 90 , APD 75 , APD 50 , APD 25 , Triangulation and maximal and minimal values of V and dV/dt during the AP (V max , V min , dV/dt max , dV/dt min ). Our results show that: 1) I Ca,L inactivation characteristics differed significantly when calculated from model equations and from simulations reproducing the experimental protocols. 2) Large differences were found in the ionic currents contributors to APD 25 , Triangulation, V max , dV/dt max and dV/dt min between single cells and 1D-tissue. When proposing any new model formulation, or evaluating an existing model, consistency between simulated and experimental data should be verified considering all involved effects and scales. Copyright © 2016 Elsevier Ltd. All rights reserved.

Don't wait to incubate: immediate versus delayed incubation in divergent thinking.

PubMed

Gilhooly, Kenneth J; Georgiou, George J; Garrison, Jane; Reston, Jon D; Sirota, Miroslav

2012-08-01

Previous evidence for the effectiveness of immediate incubation in divergent creative tasks has been weak, because earlier studies exhibited a range of methodological problems. This issue is theoretically important, as a demonstration of the effects of immediate incubation would strengthen the case for the involvement of unconscious work in incubation effects. For the present experiment, we used a creative divergent-thinking task (alternative uses) in which separate experimental groups had incubation periods that were either delayed or immediate and that consisted of either spatial or verbal tasks. Control groups were tested without incubation periods, and we carried out checks for intermittent conscious work on the target task during the incubation periods. The results showed significant incubation effects that were stronger for immediate than for delayed incubation. Performance was not different between the verbal and spatial incubation conditions, and we found no evidence for intermittent conscious working during the incubation periods. These results support a role for unconscious work in creative divergent thinking, particularly in the case of immediate incubation.

The impact of cognitive control, incentives, and working memory load on the P3 responses of externalizing prisoners.

PubMed

Baskin-Sommers, Arielle R; Krusemark, Elizabeth A; Curtin, John J; Lee, Christopher; Vujnovich, Aleice; Newman, Joseph P

2014-02-01

The P3 amplitude reduction is one of the most common correlates of externalizing. However, few studies have used experimental manipulations designed to challenge different cognitive functions in order to clarify the processes that impact this reduction. To examine factors moderating P3 amplitude in trait externalizing, we administered an n-back task that manipulated cognitive control demands, working memory load, and incentives to a sample of male offenders. Offenders with high trait externalizing scores did not display a global reduction in P3 amplitude. Rather, the negative association between trait externalizing and P3 amplitude was specific to trials involving inhibition of a dominant response during infrequent stimuli, in the context of low working memory load, and incentives for performance. In addition, we discuss the potential implications of these findings for externalizing-related psychopathologies. The results complement and expand previous work on the process-level dysfunction contributing to externalizing-related deficits in P3. Copyright © 2013 Elsevier B.V. All rights reserved.

Age- and diabetes-related nonenzymatic crosslinks in collagen fibrils: candidate amino acids involved in Advanced Glycation End-products.

PubMed

Gautieri, Alfonso; Redaelli, Alberto; Buehler, Markus J; Vesentini, Simone

2014-02-01

Ageing and diabetes share a common deleterious phenomenon, the formation of Advanced Glycation Endproducts (AGEs), which accumulate predominantly in collagen due to its low turnover. Though the general picture of glycation has been identified, the detailed knowledge of which collagen amino acids are involved in AGEs is still missing. In this work we use an atomistic model of a collagen fibril to pinpoint, for the first time, the precise location of amino acids involved in the most relevant AGE, glucosepane. The results show that there are 14 specific lysine-arginine pairs that, due to their relative position and configuration, are likely to form glucosepane. We find that several residues involved in AGE crosslinks are within key collagen domains, such as binding sites for integrins, proteoglycans and collagenase, hence providing molecular-level explanations of previous experimental results showing decreased collagen affinity for key molecules. Altogether, these findings reveal the molecular mechanism by which glycation affects the biological properties of collagen tissues, which in turn contribute to age- and diabetes-related pathological states. © 2013.

PDGF activates K-Cl cotransport through phosphoinositide 3-kinase and protein phosphatase-1 in primary cultures of vascular smooth muscle cells.

PubMed

Zhang, Jing; Lauf, Peter K; Adragna, Norma C

2005-07-15

K-Cl cotransport (K-Cl COT, KCC) is an electroneutrally coupled movement of K and Cl present in most cells. In this work, we studied the pathways of regulation of K-Cl COT by platelet-derived growth factor (PDGF) in primary cultures of vascular smooth muscle cells (VSMCs). Wortmannin and LY 294002 blocked the PDGF-induced K-Cl COT activation, indicating that the phosphoinositide 3-kinase (PI 3-K) pathway is involved. However, PD 98059 had no effect on K-Cl COT activation by PDGF, suggesting that the mitogen-activated protein kinase pathway is not involved under the experimental conditions tested. Involvement of phosphatases was also examined. Sodium orthovanadate, cyclosporin A and okadaic acid had no effect on PDGF-stimulated K-Cl COT. Calyculin A blocked the PDGF-stimulated K-Cl COT by 60%, suggesting that protein phosphatase-1 (PP-1) is a mediator in the PDGF signaling pathway/s. In conclusion, our results indicate that the PDGF-mediated pathways of K-Cl COT regulation involve the signaling molecules PI 3-K and PP-1.

Breakup of loosely bound nuclei at intermediate energies for nuclear astrophysics and the development of a position sensitive microstrip detector system and its readout electronics using ASICs technologies

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bertulani, Carlos A.

2016-01-12

The work performed under this grant has led to the development of a detection system that will be used to measure reaction rates for proton or neutron capture reactions at stellar energies on radioactive ions far from stability. The reaction rates are needed to better understand the physics of nucleosynthesis in explosive stellar processes such as supernovae and x-ray burst events. The radioactive ions will be produced at the Radioactive Ion Beam Facility (RIBF) at RIKEN near Tokyo, Japan. During the course of this work, the group involved in this project has expanded by several institutions in Europe and Japanmore » and now involves collaborators from the U.S., Japan, Hungary, Romania, Germany, Spain, Italy, China, and South Korea. As part of the project, a novel design based on large-area silicon detectors has been built and tested. The work has involved mechanical construction of a special purpose vacuum chamber, with a precision mounting system for the silicon detectors, development of a new ASICs readout system that has applications with a wide variety of silicon detector systems, and the development of a data acquisition system that is integrated into the computer system being used at RIBF. The parts noted above that are needed to carry out the research program are completed and ready for installation. Several approved experiments that will use this system will be carried out in the near future. The experimental work has been delayed due to a large increase in the cost and availability of electrical power for RIBF that occurred following the massive earthquake and tsunami that hit Japan in the spring of 2011. Another component of the research carried out with this grant involved developing the theoretical tools that are required to extract the information from the experiments that is needed to determine the stellar reaction rates. The tools developed through this part of the work will be made freely available for general use.« less

Structure of Nuclei Far From Stability

DOE Office of Scientific and Technical Information (OSTI.GOV)

Blackmon, Jeffery C.; Tribble, Robert E.; Sobotka, Lee G.

2015-12-29

The work performed under this grant has led to the development of a detection system that will be used to measure reaction rates for proton or neutron capture reactions at stellar energies on radioactive ions far from stability. The reaction rates are needed to better understand the physics of nucleosynthesis in explosive stellar processes such as supernovae and X-ray burst explosions. The radioactive ions will be produced at the Radioactive Ion Beam Facility (RIBF) at RIKEN near Tokyo, Japan. During the course of this work, the group involved in this project has expanded by several institutions in Europe and Japanmore » and now involves collaborators from the U.S., Japan, Hungary, Romania, Germany, Spain, Italy, China, and South Korea. As part of the project, a novel design based on large-area silicon detectors has been built and tested and the performance characterized in a series of tests using particle beams with a variety of atomic numbers at the Cyclotron Institute of Texas A&M University and the Heavy Ion Medical Accelerator in Chiba facility (HIMAC) in Chiba, Japan. The work has involved mechanical construction of a special purpose vacuum chamber, with a precision mounting system for the silicon detectors, development of a new ASICs readout system that has applications with a wide variety of silicon detector systems, and the development of a data acquisition system that is integrated into the computer system being used at RIBF. The parts noted above that are needed to carry out the research program are completed and ready for installation. Several approved experiments that will use this system will be carried out in the near future. The experimental work has been delayed due to a large increase in the cost and availability of electrical power for RIBF that occurred following the massive earthquake and tsunami that hit Japan in the spring of 2011. Another component of the research carried out with this grant involved developing the theoretical tools that are required to extract the information from the experiments that is needed to determine the stellar reaction rates. The tools developed through this part of the work will be made freely available for general use.« less

Sustained hyperhydration with glycerol ingestion.

PubMed

Koenigsberg, P S; Martin, K K; Hlava, H R; Riedesel, M L

1995-01-01

Heavy exercise lasting more than three hours tends to result in dehydration, as the fluid intake is less than fluid loss by sweat and urine. Dehydration as small as one percent of body weight has been reported to decrease work capacity. In present and previous studies insensible water loss and sweat are assumed to be the same in both control and experimental conditions. Fluid intake less urine volume is utilized as an indicator of euhydration, hypohydration, or hyperhydration. Previous studies involving glycerol intake describe hyperhydration for 4.5 to 8 hours. The objective of this study was to keep subjects hyperhydrated (retention of water) for 32 or 49 hours. The experimental protocol involved ingestion of a large volume of fluid (39.2 or 51.1 ml/kg/d) with glycerol (2.9 to 3.1 g/kg/d) and without glycerol. In both Series I (49 h) and Series II (32 h) experiments, the intake of glycerol resulted in smaller urine volumes. This study demonstrates it is possible to keep human subjects hyperhydrated for extended periods of time and thereby reduce the amount of fluid consumption necessary just prior to or during bouts of negative fluid balance situations.

Sustained prediction ability of net analyte preprocessing methods using reduced calibration sets. Theoretical and experimental study involving the spectrophotometric analysis of multicomponent mixtures.

PubMed

Goicoechea, H C; Olivieri, A C

2001-07-01

A newly developed multivariate method involving net analyte preprocessing (NAP) was tested using central composite calibration designs of progressively decreasing size regarding the multivariate simultaneous spectrophotometric determination of three active components (phenylephrine, diphenhydramine and naphazoline) and one excipient (methylparaben) in nasal solutions. Its performance was evaluated and compared with that of partial least-squares (PLS-1). Minimisation of the calibration predicted error sum of squares (PRESS) as a function of a moving spectral window helped to select appropriate working spectral ranges for both methods. The comparison of NAP and PLS results was carried out using two tests: (1) the elliptical joint confidence region for the slope and intercept of a predicted versus actual concentrations plot for a large validation set of samples and (2) the D-optimality criterion concerning the information content of the calibration data matrix. Extensive simulations and experimental validation showed that, unlike PLS, the NAP method is able to furnish highly satisfactory results when the calibration set is reduced from a full four-component central composite to a fractional central composite, as expected from the modelling requirements of net analyte based methods.

Review of computational fluid dynamics applications in biotechnology processes.

PubMed

Sharma, C; Malhotra, D; Rathore, A S

2011-01-01

Computational fluid dynamics (CFD) is well established as a tool of choice for solving problems that involve one or more of the following phenomena: flow of fluids, heat transfer,mass transfer, and chemical reaction. Unit operations that are commonly utilized in biotechnology processes are often complex and as such would greatly benefit from application of CFD. The thirst for deeper process and product understanding that has arisen out of initiatives such as quality by design provides further impetus toward usefulness of CFD for problems that may otherwise require extensive experimentation. Not surprisingly, there has been increasing interest in applying CFD toward a variety of applications in biotechnology processing in the last decade. In this article, we will review applications in the major unit operations involved with processing of biotechnology products. These include fermentation,centrifugation, chromatography, ultrafiltration, microfiltration, and freeze drying. We feel that the future applications of CFD in biotechnology processing will focus on establishing CFD as a tool of choice for providing process understanding that can be then used to guide more efficient and effective experimentation. This article puts special emphasis on the work done in the last 10 years. © 2011 American Institute of Chemical Engineers

Sodium bicarbonate supplementation improves severe-intensity intermittent exercise under moderate acute hypoxic conditions.

PubMed

Deb, Sanjoy K; Gough, Lewis A; Sparks, S Andy; McNaughton, Lars R

2018-03-01

Acute moderate hypoxic exposure can substantially impair exercise performance, which occurs with a concurrent exacerbated rise in hydrogen cation (H + ) production. The purpose of this study was therefore, to alleviate this acidic stress through sodium bicarbonate (NaHCO 3 ) supplementation and determine the corresponding effects on severe-intensity intermittent exercise performance. Eleven recreationally active individuals participated in this randomised, double-blind, crossover study performed under acute normobaric hypoxic conditions (FiO 2 % = 14.5%). Pre-experimental trials involved the determination of time to attain peak bicarbonate anion concentrations ([HCO 3 - ]) following NaHCO 3 ingestion. The intermittent exercise tests involved repeated 60-s work in their severe-intensity domain and 30-s recovery at 20 W to exhaustion. Participants ingested either 0.3 g kg bm -1 of NaHCO 3 or a matched placebo of 0.21 g kg bm -1 of sodium chloride prior to exercise. Exercise tolerance (+ 110.9 ± 100.6 s; 95% CI 43.3-178 s; g = 1.0) and work performed in the severe-intensity domain (+ 5.8 ± 6.6 kJ; 95% CI 1.3-9.9 kJ; g = 0.8) were enhanced with NaHCO 3 supplementation. Furthermore, a larger post-exercise blood lactate concentration was reported in the experimental group (+ 4 ± 2.4 mmol l -1 ; 95% CI 2.2-5.9; g = 1.8), while blood [HCO 3 - ] and pH remained elevated in the NaHCO 3 condition throughout experimentation. In conclusion, this study reported a positive effect of NaHCO 3 under acute moderate hypoxic conditions during intermittent exercise and therefore, may offer an ergogenic strategy to mitigate hypoxic induced declines in exercise performance.

The effects of human relations training on reported teacher stress, pupil control ideology and locus of control.

PubMed

Hall, E; Hall, C; Abaci, R

1997-12-01

This study presents the reported outcomes of a two-year, part-time Masters' programme in human relations using an experiential learning methodology based mainly on humanistic psychological theory. The following hypotheses were examined. That as a result of the two-year programme: the experience of reported stress would be reduced; reported attitudes to student classroom control would shift from custodial to humanistic; there would be an increase in reports from participants of a sense of control over their lives; changes of behaviour in work, social settings and at home related to these three variables would be reported. Involved in the study were 42 experienced teachers. These included 32 women and 10 men, with an average age of 35, who worked in a wide range of educational institutions. Their learning style preferences were also considered as independent variables. A control group of 42 was established with similar demographic characteristics. Prior to the course, the experimental group and the control group were given the Maslach Burnout Inventory and the Pupil Control Ideology Form. In the early stages of the course, the experimental group completed the Kolb Learning Style Inventory and an informal measure of locus of control which was repeated at the end of the first year of the course. A sample of 32 from the experimental group were given semi-structured interviews relating to changes in their professional and personal lives. The results indicated that, following the training, there was a reduction in reported stress, indications of a more humanistic orientation towards pupil control and an increase in a sense of an internal locus of control. The quantitative data were confirmed by qualitative data generated from semi-structured interviews, which involved substantial reports of applications of the training in their professional and personal lives. These results provide support for including experiential human relations training as part of both the in-service and initial teacher training programmes.

Development of a Pyramid Wave-front Sensor

NASA Astrophysics Data System (ADS)

El Hadi, Kacem; Vignaux, Mael; Fusco, Thierry

2013-12-01

Within the framework of the E-ELT studies, several laboratories are involved on some instruments: HARMONY with its ATLAS adaptive optics [AO] system, EAGLE or EPICS. Most of the AO systems will probably integrate one or several pyramidal wavefront sensors, PWFS (R. Ragazzoni [1]). The coupling in an AO loop and the control in laboratory (then on sky) of this type of sensor is fundamental for the continuation of the projects related to OA systems on the E-ELT. LAM (Laboratory of Astrophysics of Marseille) is involved in particular in the VLT-SPHERE, ATLAS, EPICS projects. For the last few years, our laboratory has been carrying out different R&D activities in AO instrumentation for ELTs. An experimental AO bench is designed and being developed to allow the validation of new wave-front sensing and control concepts [2]. One the objectives of this bench, is the experimental validation of a pyramid WFS. Theoretical investigations on its behavior have been already made. The world's fastest and most sensitive camera system (OCAM2) has been recently developed at LAM (J.L Gach [3], First Light Imaging). Conjugating this advantage with the pyramid concept, we plan to demonstrate a home made Pyramid sensor for Adaptive Optics whose the speed and the precision are the key points. As a joint collaboration with ONERA and Shaktiware, our work aims at the optimization (measurement process, calibration and operation) in laboratory then on the sky of a pyramid sensor dedicated to the first generation instruments for ELTs. The sensor will be implemented on the ONERA ODISSEE AO bench combining thus a pyramid and a Shack-Hartmann wavefront sensors. What would give the possibility to compare strictly these two WFS types and make this bench unique in France and even in Europe. Experimental work on laboratory demonstration is undergoing. The status of our development will presented at the conference.

An "unreasonable effectiveness" of Hilbert transform for the transition phase behavior in an Aharonov-Bohm two-path interferometer

NASA Astrophysics Data System (ADS)

Englman, R.

2016-08-01

The recent phase shift data of Takada et al. (Phys. Rev. Lett. 113 (2014) 126601) for a two level system are reconstructed from their current intensity curves by the method of Hilbert transform, for which the underlying Physics is the principle of causality. An introductory algebraic model illustrates pedagogically the working of the method and leads to newly derived relationships involving phenomenological parameters, in particular for the sign of the phase slope between the resonance peaks. While the parametrization of the experimental current intensity data in terms of a few model parameters shows only a qualitative agreement for the phase shift, due to the strong impact of small, detailed variations in the experimental intensity curve on the phase behavior, the numerical Hilbert transform yields a satisfactory reproduction of the phase.

Brainlab: A Python Toolkit to Aid in the Design, Simulation, and Analysis of Spiking Neural Networks with the NeoCortical Simulator.

PubMed

Drewes, Rich; Zou, Quan; Goodman, Philip H

2009-01-01

Neuroscience modeling experiments often involve multiple complex neural network and cell model variants, complex input stimuli and input protocols, followed by complex data analysis. Coordinating all this complexity becomes a central difficulty for the experimenter. The Python programming language, along with its extensive library packages, has emerged as a leading "glue" tool for managing all sorts of complex programmatic tasks. This paper describes a toolkit called Brainlab, written in Python, that leverages Python's strengths for the task of managing the general complexity of neuroscience modeling experiments. Brainlab was also designed to overcome the major difficulties of working with the NCS (NeoCortical Simulator) environment in particular. Brainlab is an integrated model-building, experimentation, and data analysis environment for the powerful parallel spiking neural network simulator system NCS.

Brainlab: A Python Toolkit to Aid in the Design, Simulation, and Analysis of Spiking Neural Networks with the NeoCortical Simulator

PubMed Central

Drewes, Rich; Zou, Quan; Goodman, Philip H.

2008-01-01

Neuroscience modeling experiments often involve multiple complex neural network and cell model variants, complex input stimuli and input protocols, followed by complex data analysis. Coordinating all this complexity becomes a central difficulty for the experimenter. The Python programming language, along with its extensive library packages, has emerged as a leading “glue” tool for managing all sorts of complex programmatic tasks. This paper describes a toolkit called Brainlab, written in Python, that leverages Python's strengths for the task of managing the general complexity of neuroscience modeling experiments. Brainlab was also designed to overcome the major difficulties of working with the NCS (NeoCortical Simulator) environment in particular. Brainlab is an integrated model-building, experimentation, and data analysis environment for the powerful parallel spiking neural network simulator system NCS. PMID:19506707

Collapse of Experimental Colloidal Aging using Record Dynamics

NASA Astrophysics Data System (ADS)

Robe, Dominic; Boettcher, Stefan; Sibani, Paolo; Yunker, Peter

The theoretical framework of record dynamics (RD) posits that aging behavior in jammed systems is controlled by short, rare events involving activation of only a few degrees of freedom. RD predicts dynamics in an aging system to progress with the logarithm of t /tw . This prediction has been verified through new analysis of experimental data on an aging 2D colloidal system. MSD and persistence curves spanning three orders of magnitude in waiting time are collapsed. These predictions have also been found consistent with a number of experiments and simulations, but verification of the specific assumptions that RD makes about the underlying statistics of these rare events has been elusive. Here the observation of individual particles allows for the first time the direct verification of the assumptions about event rates and sizes. This work is suppoted by NSF Grant DMR-1207431.

Oxidation of Ethidium using TAML Activators: A Model for High School Research Performed in Partnership with University Scientists

PubMed Central

Pueyo, Natalie C.; Raub, Andrew G.; Jackson, Sean; Metz, Madalyn M.; Mount, Allegra C.; Naughton, Kyle L.; Eaton, Ashley L.; Thomas, Nicole M.; Hastings, Peter; Greaves, John; Blumberg, Bruce; Collins, Terrence J.; Sogo, Steven G.

2013-01-01

A chemical research program at a public high school has been developed. The full-year Advanced Chemical Research class (ACR) in the high school enrolls 20 to 30 seniors each year, engaging them in long-term experimental projects. Through partnerships involving university scientists, ACR high school students have had the opportunity to explore a number of highly sophisticated original research projects. As an example of the quality of experimental work made possible through these high school–university partnerships, this article describes the development of a novel method for the oxidation of ethidium bromide, a mutagen commonly used in molecular biology. Data collected from ACR alumni show that the ACR program is instrumental in encouraging students to pursue careers in scientific fields and in creating life-long problem-solvers. PMID:23585695

Oxidation of Ethidium using TAML Activators: A Model for High School Research Performed in Partnership with University Scientists.

PubMed

Pueyo, Natalie C; Raub, Andrew G; Jackson, Sean; Metz, Madalyn M; Mount, Allegra C; Naughton, Kyle L; Eaton, Ashley L; Thomas, Nicole M; Hastings, Peter; Greaves, John; Blumberg, Bruce; Collins, Terrence J; Sogo, Steven G

2013-03-12

A chemical research program at a public high school has been developed. The full-year Advanced Chemical Research class (ACR) in the high school enrolls 20 to 30 seniors each year, engaging them in long-term experimental projects. Through partnerships involving university scientists, ACR high school students have had the opportunity to explore a number of highly sophisticated original research projects. As an example of the quality of experimental work made possible through these high school-university partnerships, this article describes the development of a novel method for the oxidation of ethidium bromide, a mutagen commonly used in molecular biology. Data collected from ACR alumni show that the ACR program is instrumental in encouraging students to pursue careers in scientific fields and in creating life-long problem-solvers.

Tissue Anisotropy Modeling Using Soft Composite Materials.

PubMed

Chanda, Arnab; Callaway, Christian

2018-01-01

Soft tissues in general exhibit anisotropic mechanical behavior, which varies in three dimensions based on the location of the tissue in the body. In the past, there have been few attempts to numerically model tissue anisotropy using composite-based formulations (involving fibers embedded within a matrix material). However, so far, tissue anisotropy has not been modeled experimentally. In the current work, novel elastomer-based soft composite materials were developed in the form of experimental test coupons, to model the macroscopic anisotropy in tissue mechanical properties. A soft elastomer matrix was fabricated, and fibers made of a stiffer elastomer material were embedded within the matrix material to generate the test coupons. The coupons were tested on a mechanical testing machine, and the resulting stress-versus-stretch responses were studied. The fiber volume fraction (FVF), fiber spacing, and orientations were varied to estimate the changes in the mechanical responses. The mechanical behavior of the soft composites was characterized using hyperelastic material models such as Mooney-Rivlin's, Humphrey's, and Veronda-Westmann's model and also compared with the anisotropic mechanical behavior of the human skin, pelvic tissues, and brain tissues. This work lays the foundation for the experimental modelling of tissue anisotropy, which combined with microscopic studies on tissues can lead to refinements in the simulation of localized fiber distribution and orientations, and enable the development of biofidelic anisotropic tissue phantom materials for various tissue engineering and testing applications.

Tissue Anisotropy Modeling Using Soft Composite Materials

PubMed Central

Callaway, Christian

2018-01-01

Soft tissues in general exhibit anisotropic mechanical behavior, which varies in three dimensions based on the location of the tissue in the body. In the past, there have been few attempts to numerically model tissue anisotropy using composite-based formulations (involving fibers embedded within a matrix material). However, so far, tissue anisotropy has not been modeled experimentally. In the current work, novel elastomer-based soft composite materials were developed in the form of experimental test coupons, to model the macroscopic anisotropy in tissue mechanical properties. A soft elastomer matrix was fabricated, and fibers made of a stiffer elastomer material were embedded within the matrix material to generate the test coupons. The coupons were tested on a mechanical testing machine, and the resulting stress-versus-stretch responses were studied. The fiber volume fraction (FVF), fiber spacing, and orientations were varied to estimate the changes in the mechanical responses. The mechanical behavior of the soft composites was characterized using hyperelastic material models such as Mooney-Rivlin's, Humphrey's, and Veronda-Westmann's model and also compared with the anisotropic mechanical behavior of the human skin, pelvic tissues, and brain tissues. This work lays the foundation for the experimental modelling of tissue anisotropy, which combined with microscopic studies on tissues can lead to refinements in the simulation of localized fiber distribution and orientations, and enable the development of biofidelic anisotropic tissue phantom materials for various tissue engineering and testing applications. PMID:29853996

Redesigning the work system of rubber industries based on total ergonomics and ergo-micmac integration

NASA Astrophysics Data System (ADS)

Setiawan, H.

2018-01-01

The factory capacity achievement and the bottleneck reduction of production process at wet-blanket workstations are influenced by the balance of life quality rates and worker’s productivity, along with the worker’s ability and limitations, tasks, organization and work environment. The life quality of workers is indicated by: the reduction of workload, and fatigue. Meanwhile, work productivity is measured by increasing production results per work shift. The optimization of the quality of life and productivity of workers is achieved by redesigning the system and workstations based on ergonomics integrating Total Ergonomics with Ergo-MicMac (Micro Ergonomics and Macro Ergonomics), which includes redesigning wet-blanket folding worktable, regulating the system pattern of working in pairs, giving official break time, giving extra nutritious intakes such as sweet tea and snack Pempek, giving personal protective equipments, and redesigning physical working environments.This study was an experimental study, with treatment by subject design involving 30 workers sampled at a workstation condition before and after Ergonomics based redesign. The findings and conclusions of the study were derived from the reduction of the workload by 16.06%, fatigue by 18.84% and the increase of production results per work shift by 20.29%.

Ergonomic Work Station Design to Improve Workload Quality and Productivity of the Craffsmen

NASA Astrophysics Data System (ADS)

Widana, IK; Wayan Sumetri, Ni; Ketut Sutapa, I.

2018-01-01

This study is a research on ergonomics field, especially for ergonomics work station. This research begins with direct observation on the work process of carving craft. In addition to the aspect of occupational health, the stages of the process are also subject matter in the effort to solve the research problem. In accordance with the master plan of research of Bali State Polytechnic, problem solving will be focused on human aspect and utilization of appropriate technology, so that will get the work process ENASEP (effective, convenient, safe, healthy, efficient and productive) Technical easy to work, economical, ergonomic, energy saving, environmentally friendly and in accordance with the trend of the era. The method to be used in this research is experimental with the same subject design. Involves 9 samples who perform activities on conditions before and after treatment. Data on environmental conditions were analyzed by Mann-Whitney test. Data on work productivity and workload were tested with two pair sample t-test at a significance level of 5%. The results showed that by utilizing ergonomic work stations, occupational health indicators such as workload showed better signs, indicated by decreased the workload. In addition to occupational health, productivity indicators also increased significantly.

Why orphan drug coverage reimbursement decision-making needs patient and public involvement.

PubMed

Douglas, Conor M W; Wilcox, Elizabeth; Burgess, Michael; Lynd, Larry D

2015-05-01

Recently there has been an increase in the active involvement of publics and patients in healthcare and research, which is extending their roles beyond the passive recipients of medicines. However, there has been noticeably less work engaging them into decision-making for healthcare rationing exercises, priority setting, health technology assessment, and coverage decision-making. This is particularly evident in reimbursement decision-making for 'orphan drugs' or drugs for rare diseases. Medicinal products for rare disease offer particular challenges in coverage decision-making because they often lack the 'evidence of efficacy' profiles of common drugs that have been trialed on larger populations. Furthermore, many of these drugs are priced in the high range, and with limited health care budgets the prospective opportunity costs of funding them means that those resources cannot be allocated elsewhere. Here we outline why decision-making for drugs for rare diseases could benefit from increased levels of publics and patients involvement, suggest some possible forms that involvement could take, and advocate for empirical experimentation in this area to evaluate the effects of such involvement. Focus is given to the Canadian context in which we are based; however, potentialities and challenges relating to involvement in this area are likely to be similar elsewhere. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

Propagation of fires along mine workings: criteria and limits

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pervushin, Yu.V.

1978-01-01

Underground fires account for over 50% of the accidents occuring in Soviet mines. Their prevention therefore occupies a central place in mine rescue practice and accident prevention. The general features of the physical processes occurring during propagation of a flame have been studied in some detail. Attempts have been made to describe underground fires on the basis of experimental data. However, it is not yet possible to make accurate preductions of the behavior of fires in mine workings: very many factors influence their development. The dynamics of spread of a flame along a working involves such diverse phenomena as heatmore » transfer by thermal conduction, radiation, and convection, transfer of oxygen and combustible gaseous components by draughts and diffusion, various chemical reactions on the surface of combustible materials and within the flames, and finally complex surface effects accompanying heat and mass transfer at interfaces between media. In addition, we must take account of the specific conditions prevailing in a mine - the complex geometrical configuration of the workings, the nonuniformity of the combustible materials, and the role of ventilation and its instability during fires. There can be many approaches to the study of such a many-sided process. The most promising lines seem to be those in which experimental models of the complex of possible phenomena are combined with mathematical models of the process, based on the equations of chemical hydrodynamics, in which the alternative variants are realized on a computer.« less

Aircraft engine hot section technology: An overview of the HOST Project

NASA Technical Reports Server (NTRS)

Sokolowski, Daniel E.; Hirschberg, Marvin H.

1990-01-01

NASA sponsored the Turbine Engine Hot Section (HOST) project to address the need for improved durability in advanced aircraft engine combustors and turbines. Analytical and experimental activities aimed at more accurate prediction of the aerothermal environment, the thermomechanical loads, the material behavior and structural responses to loads, and life predictions for cyclic high temperature operation were conducted from 1980 to 1987. The project involved representatives from six engineering disciplines who are spread across three work disciplines - industry, academia, and NASA. The HOST project not only initiated and sponsored 70 major activities, but also was the keystone in joining the multiple disciplines and work sectors to focus on critical research needs. A broad overview of the project is given along with initial indications of the project's impact.

Embryonic vaccines against cancer: an early history.

PubMed

Brewer, Bradley G; Mitchell, Robert A; Harandi, Amir; Eaton, John W

2009-06-01

Almost 100 years have passed since the seminal observations of Schöne showing that vaccination of animals with fetal tissue would prevent the growth of transplantable tumors. Many subsequent reports have affirmed the general idea that immunologic rejection of transplantable tumors, as well as prevention of carcinogenesis, may be affected by vaccination with embryonic/fetal material. Following a decade of intense research on this phenomenon during approximately 1964-1974, interest appears to have waned. This earlier experimental work may be particularly pertinent in view of the rising interest in so-called cancer stem cells. We believe that further work - perhaps involving the use of embryonic stem cells as immunogens - is warranted and that the results reviewed herein support the concept that vaccination against the appearance of cancers of all kinds is a real possibility.

A Preliminary Study on the Vapor/Mist Phase Lubrication of a Spur Gearbox

NASA Technical Reports Server (NTRS)

Morales, Wilfredo; Handschuh, Robert F.

1999-01-01

Organophosphates have been the primary compounds used in vapor/mist phase lubrication studies involving ferrous bearing material. Experimental results have indicated that the initial formation of an iron phosphate film on a rubbing ferrous surface, followed by the growth (by cationic diffusion) of a lubricious pyrophosphate-type coating over the iron phosphate, is the reason organophosphates work well as vapor/mist phase lubricants. Recent work, however, has shown that this mechanism leads to the depletion of surface iron atoms and to eventual lubrication failure. A new organophosphate formulation was developed which circumvents surface iron depletion. This formulation was tested by generating an iron phosphate coating on an aluminum surface. The new formulation was then used to vapor/mist phase lubricate a spur gearbox in a preliminary study.

Thermal Spray Maps: Material Genomics of Processing Technologies

NASA Astrophysics Data System (ADS)

Ang, Andrew Siao Ming; Sanpo, Noppakun; Sesso, Mitchell L.; Kim, Sun Yung; Berndt, Christopher C.

2013-10-01

There is currently no method whereby material properties of thermal spray coatings may be predicted from fundamental processing inputs such as temperature-velocity correlations. The first step in such an important understanding would involve establishing a foundation that consolidates the thermal spray literature so that known relationships could be documented and any trends identified. This paper presents a method to classify and reorder thermal spray data so that relationships and correlations between competing processes and materials can be identified. Extensive data mining of published experimental work was performed to create thermal spray property-performance maps, known as "TS maps" in this work. Six TS maps will be presented. The maps are based on coating characteristics of major importance; i.e., porosity, microhardness, adhesion strength, and the elastic modulus of thermal spray coatings.

High-temperature experimental and thermodynamic modelling research on the pyrometallurgical processing of copper

NASA Astrophysics Data System (ADS)

Hidayat, Taufiq; Shishin, Denis; Decterov, Sergei A.; Hayes, Peter C.; Jak, Evgueni

2017-01-01

Uncertainty in the metal price and competition between producers mean that the daily operation of a smelter needs to target high recovery of valuable elements at low operating cost. Options for the improvement of the plant operation can be examined and decision making can be informed based on accurate information from laboratory experimentation coupled with predictions using advanced thermodynamic models. Integrated high-temperature experimental and thermodynamic modelling research on phase equilibria and thermodynamics of copper-containing systems have been undertaken at the Pyrometallurgy Innovation Centre (PYROSEARCH). The experimental phase equilibria studies involve high-temperature equilibration, rapid quenching and direct measurement of phase compositions using electron probe X-ray microanalysis (EPMA). The thermodynamic modelling deals with the development of accurate thermodynamic database built through critical evaluation of experimental data, selection of solution models, and optimization of models parameters. The database covers the Al-Ca-Cu-Fe-Mg-O-S-Si chemical system. The gas, slag, matte, liquid and solid metal phases, spinel solid solution as well as numerous solid oxide and sulphide phases are included. The database works within the FactSage software environment. Examples of phase equilibria data and thermodynamic models of selected systems, as well as possible implementation of the research outcomes to selected copper making processes are presented.

41 CFR 102-5.80 - What are some examples of positions that may involve field work?

Code of Federal Regulations, 2010 CFR

2010-07-01

... of positions that may involve field work? 102-5.80 Section 102-5.80 Public Contracts and Property...-HOME-TO-WORK TRANSPORTATION Authorizing Home-to-Work Transportation § 102-5.80 What are some examples of positions that may involve field work? Examples of positions that may involve field work include...

41 CFR 102-5.80 - What are some examples of positions that may involve field work?

Code of Federal Regulations, 2013 CFR

2013-07-01

... of positions that may involve field work? 102-5.80 Section 102-5.80 Public Contracts and Property...-HOME-TO-WORK TRANSPORTATION Authorizing Home-to-Work Transportation § 102-5.80 What are some examples of positions that may involve field work? Examples of positions that may involve field work include...

41 CFR 102-5.80 - What are some examples of positions that may involve field work?

Code of Federal Regulations, 2012 CFR

2012-01-01

... of positions that may involve field work? 102-5.80 Section 102-5.80 Public Contracts and Property...-HOME-TO-WORK TRANSPORTATION Authorizing Home-to-Work Transportation § 102-5.80 What are some examples of positions that may involve field work? Examples of positions that may involve field work include...

41 CFR 102-5.80 - What are some examples of positions that may involve field work?

Code of Federal Regulations, 2011 CFR

2011-01-01

... of positions that may involve field work? 102-5.80 Section 102-5.80 Public Contracts and Property...-HOME-TO-WORK TRANSPORTATION Authorizing Home-to-Work Transportation § 102-5.80 What are some examples of positions that may involve field work? Examples of positions that may involve field work include...

41 CFR 102-5.80 - What are some examples of positions that may involve field work?

Code of Federal Regulations, 2014 CFR

2014-01-01

... of positions that may involve field work? 102-5.80 Section 102-5.80 Public Contracts and Property...-HOME-TO-WORK TRANSPORTATION Authorizing Home-to-Work Transportation § 102-5.80 What are some examples of positions that may involve field work? Examples of positions that may involve field work include...

Precison Muon Physics

NASA Astrophysics Data System (ADS)

Hertzog, David

2013-04-01

The worldwide, vibrant experimental program involving precision measurements with muons will be presented. Recent achievements in this field have greatly improved our knowledge of fundamental parameters: Fermi constant (lifetime), weak-nucleon pseudoscalar coupling (μp capture), Michel decay parameters, and the proton charged radius (Lamb shift). The charged-lepton-violating decay μ->eγ sets new physics limits. Updated Standard Model theory evaluations of the muon anomalous magnetic moment has increased the significance beyond 3 σ for the deviation with respect to experiment. Next-generation experiments are mounting, with ambitious sensitivity goals for the muon-to-electron search approaching 10-17 sensitivity and for a 0.14 ppm determination of g-2. The broad physics reach of these efforts involves atomic, nuclear and particle physics communities. I will select from recent work and outline the most important efforts that are in preparation.

Dynamics of Infection and Spread of Diseases

NASA Astrophysics Data System (ADS)

Zorzenon dos Santos, Rita Maria

2003-03-01

This text summarizes a series of four lectures presented at the PASI on Modern Challenges in Statistical Mechanics. The idea was to give to the students a flavor of the biological aspects involved in the dynamics of infection and the spread of diseases, the complexity of the systems involved, and how we can improve our modeling of such systems by using different approaches in order to get closer to experimental results. In a huge universe of publications about the subject, we restrict the list of references to the ones that may be useful to the students and will lead them to other important work. Therefore, the text should not be taken as a review of the subject, but rather as an introductory text for physicists about the dynamics of infection and spread of diseases and the role of biological physics in this interdisciplinary field.

Geo-material microfluidics at reservoir conditions for subsurface energy resource applications.

PubMed

Porter, Mark L; Jiménez-Martínez, Joaquín; Martinez, Ricardo; McCulloch, Quinn; Carey, J William; Viswanathan, Hari S

2015-10-21

Microfluidic investigations of flow and transport in porous and fractured media have the potential to play a significant role in the development of future subsurface energy resource technologies. However, the majority of experimental systems to date are limited in applicability due to operating conditions and/or the use of engineered material micromodels. We have developed a high pressure and temperature microfluidic experimental system that allows for direct observations of flow and transport within geo-material micromodels (e.g. rock, cement) at reservoir conditions. In this manuscript, we describe the experimental system, including our novel micromodel fabrication method that works in both geo- and engineered materials and utilizes 3-D tomography images of real fractures as micromodel templates to better represent the pore space and fracture geometries expected in subsurface formations. We present experimental results that highlight the advantages of using real-rock micromodels and discuss potential areas of research that could benefit from geo-material microfluidic investigations. The experiments include fracture-matrix interaction in which water imbibes into the shale rock matrix from etched fractures, supercritical CO2 (scCO2) displacing brine in idealized and realistic fracture patterns, and three-phase flow involving scCO2-brine-oil.

Jet-mixing of initially-stratified liquid-liquid pipe flows: experiments and numerical simulations

NASA Astrophysics Data System (ADS)

Wright, Stuart; Ibarra-Hernandes, Roberto; Xie, Zhihua; Markides, Christos; Matar, Omar

2016-11-01

Low pipeline velocities lead to stratification and so-called 'phase slip' in horizontal liquid-liquid flows due to differences in liquid densities and viscosities. Stratified flows have no suitable single point for sampling, from which average phase properties (e.g. fractions) can be established. Inline mixing, achieved by static mixers or jets in cross-flow (JICF), is often used to overcome liquid-liquid stratification by establishing unstable two-phase dispersions for sampling. Achieving dispersions in liquid-liquid pipeline flows using JICF is the subject of this experimental and modelling work. The experimental facility involves a matched refractive index liquid-liquid-solid system, featuring an ETFE test section, and experimental liquids which are silicone oil and a 51-wt% glycerol solution. The matching then allows the dispersed fluid phase fractions and velocity fields to be established through advanced optical techniques, namely PLIF (for phase) and PTV or PIV (for velocity fields). CFD codes using the volume of a fluid (VOF) method are then used to demonstrate JICF breakup and dispersion in stratified pipeline flows. A number of simple jet configurations are described and their dispersion effectiveness is compared with the experimental results. Funding from Cameron for Ph.D. studentship (SW) gratefully acknowledged.

ARMOUR - A Rice miRNA: mRNA Interaction Resource.

PubMed

Sanan-Mishra, Neeti; Tripathi, Anita; Goswami, Kavita; Shukla, Rohit N; Vasudevan, Madavan; Goswami, Hitesh

2018-01-01

ARMOUR was developed as A Rice miRNA:mRNA interaction resource. This informative and interactive database includes the experimentally validated expression profiles of miRNAs under different developmental and abiotic stress conditions across seven Indian rice cultivars. This comprehensive database covers 689 known and 1664 predicted novel miRNAs and their expression profiles in more than 38 different tissues or conditions along with their predicted/known target transcripts. The understanding of miRNA:mRNA interactome in regulation of functional cellular machinery is supported by the sequence information of the mature and hairpin structures. ARMOUR provides flexibility to users in querying the database using multiple ways like known gene identifiers, gene ontology identifiers, KEGG identifiers and also allows on the fly fold change analysis and sequence search query with inbuilt BLAST algorithm. ARMOUR database provides a cohesive platform for novel and mature miRNAs and their expression in different experimental conditions and allows searching for their interacting mRNA targets, GO annotation and their involvement in various biological pathways. The ARMOUR database includes a provision for adding more experimental data from users, with an aim to develop it as a platform for sharing and comparing experimental data contributed by research groups working on rice.

Microfluidic Investigation of Oil Mobilization in Shale Fracture Networks at Reservoir Conditions

NASA Astrophysics Data System (ADS)

Porter, M. L.; Jimenez-Martinez, J.; Carey, J. W.; Viswanathan, H. S.

2015-12-01

Investigations of pore-scale fluid flow and transport phenomena using engineered micromodels has steadily increased in recent years. In these investigations fluid flow is restricted to two-dimensions allowing for real time visualization and quantification of complex flow and reactive transport behavior, which is difficult to obtain in other experimental systems. One drawback to these studies is the use of engineered materials that do not faithfully represent the rock properties (e.g., porosity, wettability, roughness, etc.) encountered in subsurface formations. In this work, we describe a unique high pressure (up to 1500 psi) and temperature (up to 80 °C) microfluidics experimental system in which we investigate fluid flow and transport in geo-material (e.g., shale, Portland cement, etc.) micromodels. The use of geo-material micromodels allows us to better represent fluid-rock interactions including wettability, chemical reactivity, and nano-scale porosity at conditions representative of natural subsurface environments. Here, we present experimental results in fracture systems with applications to hydrocarbon mobility in hydraulically fractured shale. Complex fracture network patterns are derived from 3D x-ray tomography images of actual fractures created in shale rock cores. We use both shale and glass micromodels, allowing for a detailed comparison between flow phenomena in the different materials. We discuss results from two-phase huff-and-puff experiments involving N2 and n-Decane, as well as three-phase displacement experiments involving supercritical CO2, brine, and n-Decane.

Experimental and numerical analysis of coastal protection provided by natural ecosystems

NASA Astrophysics Data System (ADS)

Maza, M.; Lara, J. L.; Losada, I. J.; Nepf, H. M.

2016-12-01

The risk of flooding and erosion is increasing for many coastal areas owing to global and regional changes in climate conditions together with increasing exposure and vulnerability. After hurricane Katrina (2005) and Sandy (2012) and the tsunami in Indonesia (2004), coastal managers have become interested in low environmental impact alternatives, or nature-based solutions, to protect the coast. Although capacity for coastal ecosystems to damp flow energy has been widely recognized, they have not been firmly considered in the portfolio of coastal protection options. This is mainly due to the complexity of flow-vegetation interaction and of quantifying the value of coastal protection provided by these ecosystems. This complex problem involves different temporal and spatial scales and disciplines, such as engineering, ecology and economics. This work aims to make a step forward in better understanding the physics involved in flow-vegetation interaction leading to new formulations and parameterizations to address some unsolved questions in literature: the representation of plants and field properties; the influence of wave parameters on the relevant processes; the role of the combined effect of waves and currents and the effect of extreme events on vegetation elements. The three main coastal vegetated ecosystems (seagrasses, saltmarshes and mangroves) are studied with an experimental and numerical approach. Experimental analysis is carried out using mimics and real vegetation, considering different flow and vegetation parameters and characterizing flow energy attenuation for the different scenarios. Numerical simulations are performed using 2-D and 3-D Navier-Stokes models in which the effect of vegetation is implemented and validated. These models are used to extend experimental results by simulating different vegetation distributions and analyzing variables such as high-spatial-resolution free surface and velocity data and forces exerted on vegetation elements.

Design, Construction and Testing of Annular Diffusers for High Speed Civil Transportation Combustor Applications

NASA Technical Reports Server (NTRS)

Okhio, Cyril B.

1996-01-01

A theoretical and an experimental design study of subsonic flow through curved-wall annular diffusers has been initiated under this award in order to establish the most pertinent design parameters and hence performance characteristics for such devices, an the implications of their application in the design of engine components in the aerospace industries. The diffusers under this study are expected to contain appreciable regions of stall and the effects of swirl on their performance are being studied. The experimental work involves the application of Computer Aided Design software tool to the development of a suitable annular diffuse geometry and the subsequent downloading of such data to a CNC machine at Central State University (CSU). Two experimental run segments have been completed so far during FY-95 involving flow visualization and diffuser performance evaluation based on Kinetic Energy Dissipation. The method of calculation of the performance of diffusers based on pressure recovery coefficient has been shown to have some shortcomings and so the kinetic energy dissipation approach has been introduced in the run segment two with some success. The application of the discretized, full Navier Stokes and Continuity equations to the numerical study of the problem described above for the time-mean flow is expected to follow. Various models of turbulence are being evaluated for adoption throughout the study and comparisons would be made with experimental data where they exist. Assessment of diffuser performance based on the dissipated mechanical energy would also be made. The result of the investigations are expected to indicate that more cost effective component design of such devices as diffusers which normally contain complex flows can still be achieved.

Parents as Role Models: Parental Behavior Affects Adolescents' Plans for Work Involvement

ERIC Educational Resources Information Center

Wiese, Bettina S.; Freund, Alexandra M.

2011-01-01

This study (N = 520 high-school students) investigates the influence of parental work involvement on adolescents' own plans regarding their future work involvement. As expected, adolescents' perceptions of parental work behavior affected their plans for own work involvement. Same-sex parents served as main role models for the adolescents' own…

Evaluation of a Commercial Tractor Safety Monitoring System Using a Reverse Engineering Procedure.

PubMed

Casazza, Camilla; Martelli, Roberta; Rondelli, Valda

2016-10-17

There is a high rate of work-related deaths in agriculture. In Italy, despite the obligato-ry installation of ROPS, fatal accidents involving tractors represent more than 40% of work-related deaths in agriculture. As death is often due to an overturn that the driver is incapable of predicting, driver assistance devices that can signal critical stability conditions have been studied and marketed to prevent accidents. These devices measure the working parameters of the tractor through sensors and elaborate the values using an algorithm that, taking into account the geometric characteristics of the tractor, pro-vides a risk index based on models elaborated on a theoretical basis. This research aimed to verify one of these stability indexes in the field, using a commercial driver as-sistance device to monitor five tractors on the University of Bologna experimental farm. The setup of the device involved determining the coordinates of the center of gravity of the tractor and the implement mounted on the tractor. The analysis of the stability in-dex, limited to events with a significant risk level, revealed a clear separation into two groups: events with high values of roll or pitch and low speeds, typical of a tractor when working, and events with low values of roll and pitch and high steering angle and forward speed, typical of travel on the road. The equation for calculating the critical speed when turning provided a significant contribution only for events that were typi-cal of travel rather than field work, suggesting a diversified calculation approach ac-cording to the work phase. Copyright© by the American Society of Agricultural Engineers.

Work hours and work-family conflict: the double-edged sword of involvement in work and family.

PubMed

Matthews, Russell A; Swody, Cathleen A; Barnes-Farrell, Janet L

2012-08-01

In this study, we examine the role of work hours in a model that incorporates involvement in both work and family with experiences of work-family conflict and subjective well-being. Self-report data were collected from 383 full-time employees and analysed using structural equation modelling techniques. Results demonstrate that role salience was positively related to behavioural involvement with work and with family. In turn, behavioural family involvement was negatively related to work hours and family-to-work conflict, while behavioural work involvement was positively related to work hours. Behavioural family involvement was also positively related to life satisfaction. Finally, both family-to-work conflict and end-of-workday strain were negatively related to life satisfaction. Our results provide insight into unexpected problems that might arise when employees place overly high importance on work and work long hours. This study serves as a foundation for researchers to examine the interplay of time spent with work and family with other aspects of the work-family interface. Copyright © 2011 John Wiley & Sons, Ltd.

Preface: Special Topic on Atomic and Molecular Layer Processing: Deposition, Patterning, and Etching

NASA Astrophysics Data System (ADS)

Engstrom, James R.; Kummel, Andrew C.

2017-02-01

Thin film processing technologies that promise atomic and molecular scale control have received increasing interest in the past several years, as traditional methods for fabrication begin to reach their fundamental limits. Many of these technologies involve at their heart phenomena occurring at or near surfaces, including adsorption, gas-surface reactions, diffusion, desorption, and re-organization of near-surface layers. Moreover many of these phenomena involve not just reactions occurring under conditions of local thermodynamic equilibrium but also the action of energetic species including electrons, ions, and hyperthermal neutrals. There is a rich landscape of atomic and molecular scale interactions occurring in these systems that is still not well understood. In this Special Topic Issue of The Journal of Chemical Physics, we have collected recent representative examples of work that is directed at unraveling the mechanistic details concerning atomic and molecular layer processing, which will provide an important framework from which these fields can continue to develop. These studies range from the application of theory and computation to these systems to the use of powerful experimental probes, such as X-ray synchrotron radiation, probe microscopies, and photoelectron and infrared spectroscopies. The work presented here helps in identifying some of the major challenges and direct future activities in this exciting area of research involving atomic and molecular layer manipulation and fabrication.

Preface: Special Topic on Atomic and Molecular Layer Processing: Deposition, Patterning, and Etching.

PubMed

Engstrom, James R; Kummel, Andrew C

2017-02-07

Thin film processing technologies that promise atomic and molecular scale control have received increasing interest in the past several years, as traditional methods for fabrication begin to reach their fundamental limits. Many of these technologies involve at their heart phenomena occurring at or near surfaces, including adsorption, gas-surface reactions, diffusion, desorption, and re-organization of near-surface layers. Moreover many of these phenomena involve not just reactions occurring under conditions of local thermodynamic equilibrium but also the action of energetic species including electrons, ions, and hyperthermal neutrals. There is a rich landscape of atomic and molecular scale interactions occurring in these systems that is still not well understood. In this Special Topic Issue of The Journal of Chemical Physics, we have collected recent representative examples of work that is directed at unraveling the mechanistic details concerning atomic and molecular layer processing, which will provide an important framework from which these fields can continue to develop. These studies range from the application of theory and computation to these systems to the use of powerful experimental probes, such as X-ray synchrotron radiation, probe microscopies, and photoelectron and infrared spectroscopies. The work presented here helps in identifying some of the major challenges and direct future activities in this exciting area of research involving atomic and molecular layer manipulation and fabrication.

Gene fusion analysis in the battle against the African endemic sleeping sickness.

PubMed

Trimpalis, Philip; Koumandou, Vassiliki Lila; Pliakou, Evangelia; Anagnou, Nicholas P; Kossida, Sophia

2013-01-01

The protozoan Trypanosoma brucei causes African Trypanosomiasis or sleeping sickness in humans, which can be lethal if untreated. Most available pharmacological treatments for the disease have severe side-effects. The purpose of this analysis was to detect novel protein-protein interactions (PPIs), vital for the parasite, which could lead to the development of drugs against this disease to block the specific interactions. In this work, the Domain Fusion Analysis (Rosetta Stone method) was used to identify novel PPIs, by comparing T. brucei to 19 organisms covering all major lineages of the tree of life. Overall, 49 possible protein-protein interactions were detected, and classified based on (a) statistical significance (BLAST e-value, domain length etc.), (b) their involvement in crucial metabolic pathways, and (c) their evolutionary history, particularly focusing on whether a protein pair is split in T. brucei and fused in the human host. We also evaluated fusion events including hypothetical proteins, and suggest a possible molecular function or involvement in a certain biological process. This work has produced valuable results which could be further studied through structural biology or other experimental approaches so as to validate the protein-protein interactions proposed here. The evolutionary analysis of the proteins involved showed that, gene fusion or gene fission events can happen in all organisms, while some protein domains are more prone to fusion and fission events and present complex evolutionary patterns.

The roles of fluid motion and other transport phenomena in the morphology of materials

NASA Technical Reports Server (NTRS)

Saville, D. A.

1993-01-01

Two crystallization problems were studied: the growth of protein crystals, in particular the influence of colloidal forces and convection, and the influence of interface resistance on the growth of dendritic crystals. The protein study involved both experimental and theoretical work; the work of dendrites was entirely theoretical. In the study of protein crystallization, experiments were carried out where crystals were grown in the presence and absence of natural convection. No evidence was found that convection retards crystal growth. The theoretical study focused on the influence of colloidal forces (electrostatic and London-van der Waals) on the interaction between a protein molecule and a flat crystal surface. It was shown that the interaction is extremely sensitive to colloidal forces and that electrostatic interactions play a strong role in deciding whether or not a molecule will find a favorable site for adsorption. In the study of dendritic growth, the role of an interfacial resistance on the selection processes was examined. Using a computational scheme, it was found that the selected velocity is strongly dependent on the magnitude of the interfacial resistance to heat transfer. This is a possible explanation for discrepancies between the theoretical and experimental results on succinonitrile.

External gear pumps operating with non-Newtonian fluids: Modelling and experimental validation

NASA Astrophysics Data System (ADS)

Rituraj, Fnu; Vacca, Andrea

2018-06-01

External Gear Pumps are used in various industries to pump non-Newtonian viscoelastic fluids like plastics, paints, inks, etc. For both design and analysis purposes, it is often a matter of interest to understand the features of the displacing action realized by meshing of the gears and the description of the behavior of the leakages for this kind of pumps. However, very limited work can be found in literature about methodologies suitable to model such phenomena. This article describes the technique of modelling external gear pumps that operate with non-Newtonian fluids. In particular, it explains how the displacing action of the unit can be modelled using a lumped parameter approach which involves dividing fluid domain into several control volumes and internal flow connections. This work is built upon the HYGESim simulation tool, conceived by the authors' research team in the last decade, which is for the first time extended for the simulation of non-Newtonian fluids. The article also describes several comparisons between simulation results and experimental data obtained from numerous experiments performed for validation of the presented methodology. Finally, operation of external gear pump with fluids having different viscosity characteristics is discussed.

MRMPlus: an open source quality control and assessment tool for SRM/MRM assay development.

PubMed

Aiyetan, Paul; Thomas, Stefani N; Zhang, Zhen; Zhang, Hui

2015-12-12

Selected and multiple reaction monitoring involves monitoring a multiplexed assay of proteotypic peptides and associated transitions in mass spectrometry runs. To describe peptide and associated transitions as stable, quantifiable, and reproducible representatives of proteins of interest, experimental and analytical validation is required. However, inadequate and disparate analytical tools and validation methods predispose assay performance measures to errors and inconsistencies. Implemented as a freely available, open-source tool in the platform independent Java programing language, MRMPlus computes analytical measures as recommended recently by the Clinical Proteomics Tumor Analysis Consortium Assay Development Working Group for "Tier 2" assays - that is, non-clinical assays sufficient enough to measure changes due to both biological and experimental perturbations. Computed measures include; limit of detection, lower limit of quantification, linearity, carry-over, partial validation of specificity, and upper limit of quantification. MRMPlus streamlines assay development analytical workflow and therefore minimizes error predisposition. MRMPlus may also be used for performance estimation for targeted assays not described by the Assay Development Working Group. MRMPlus' source codes and compiled binaries can be freely downloaded from https://bitbucket.org/paiyetan/mrmplusgui and https://bitbucket.org/paiyetan/mrmplusgui/downloads respectively.

A pattern recognition approach to transistor array parameter variance

NASA Astrophysics Data System (ADS)

da F. Costa, Luciano; Silva, Filipi N.; Comin, Cesar H.

2018-06-01

The properties of semiconductor devices, including bipolar junction transistors (BJTs), are known to vary substantially in terms of their parameters. In this work, an experimental approach, including pattern recognition concepts and methods such as principal component analysis (PCA) and linear discriminant analysis (LDA), was used to experimentally investigate the variation among BJTs belonging to integrated circuits known as transistor arrays. It was shown that a good deal of the devices variance can be captured using only two PCA axes. It was also verified that, though substantially small variation of parameters is observed for BJT from the same array, larger variation arises between BJTs from distinct arrays, suggesting the consideration of device characteristics in more critical analog designs. As a consequence of its supervised nature, LDA was able to provide a substantial separation of the BJT into clusters, corresponding to each transistor array. In addition, the LDA mapping into two dimensions revealed a clear relationship between the considered measurements. Interestingly, a specific mapping suggested by the PCA, involving the total harmonic distortion variation expressed in terms of the average voltage gain, yielded an even better separation between the transistor array clusters. All in all, this work yielded interesting results from both semiconductor engineering and pattern recognition perspectives.

Fluids and Materials Science Studies Utilizing the Microgravity-vibration Isolation Mount (MIM)

NASA Technical Reports Server (NTRS)

Herring, Rodney; Tryggvason, Bjarni; Duval, Walter

1998-01-01

Canada's Microgravity Sciences Program (MSP) is the smallest program of the ISS partners and so can participate in only a few, highly focused projects in order to make a scientific and technological impact. One focused project involves determining the effect of accelerations (g-jitter) on scientific measurements in a microgravity environment utilizing the Microgravity-vibration Isolation Mount (MIM). Many experiments share the common characteristic of having a fluid stage in their process. The quality of the experimental measurements have been expected to be affected by g-jitters which has lead the ISS program to include specifications to limit the level of acceleration allowed on a subset of experimental racks. From finite element analysis (FEM), the ISS structure will not be able to meet the acceleration specifications. Therefore, isolation systems are necessary. Fluid science results and materials science results show significant sensitivity to g-jitter. The work done to date should be viewed only as a first look at the issue of g-jitter sensitivity. The work should continue with high priority such that the international science community and the ISS program can address the requirement and settle on an agreed to overall approach as soon as possible.

Modeling of Particle Emission During Dry Orthogonal Cutting

NASA Astrophysics Data System (ADS)

Khettabi, Riad; Songmene, Victor; Zaghbani, Imed; Masounave, Jacques

2010-08-01

Because of the risks associated with exposure to metallic particles, efforts are being put into controlling and reducing them during the metal working process. Recent studies by the authors involved in this project have presented the effects of cutting speeds, workpiece material, and tool geometry on particle emission during dry machining; the authors have also proposed a new parameter, named the dust unit ( D u), for use in evaluating the quantity of particle emissions relative to the quantity of chips produced during a machining operation. In this study, a model for predicting the particle emission (dust unit) during orthogonal turning is proposed. This model, which is based on the energy approach combined with the microfriction and the plastic deformation of the material, takes into account the tool geometry, the properties of the worked material, the cutting conditions, and the chip segmentation. The model is validated using experimental results obtained during the orthogonal turning of 6061-T6 aluminum alloy, AISI 1018, AISI 4140 steels, and grey cast iron. A good agreement was found with experimental results. This model can help in designing strategies for reducing particle emission during machining processes, at the source.

The roles of fluid motion and other transport phenomena in the morphology of materials

NASA Astrophysics Data System (ADS)

Saville, D. A.

1993-11-01

Two crystallization problems were studied: the growth of protein crystals, in particular the influence of colloidal forces and convection, and the influence of interface resistance on the growth of dendritic crystals. The protein study involved both experimental and theoretical work; the work of dendrites was entirely theoretical. In the study of protein crystallization, experiments were carried out where crystals were grown in the presence and absence of natural convection. No evidence was found that convection retards crystal growth. The theoretical study focused on the influence of colloidal forces (electrostatic and London-van der Waals) on the interaction between a protein molecule and a flat crystal surface. It was shown that the interaction is extremely sensitive to colloidal forces and that electrostatic interactions play a strong role in deciding whether or not a molecule will find a favorable site for adsorption. In the study of dendritic growth, the role of an interfacial resistance on the selection processes was examined. Using a computational scheme, it was found that the selected velocity is strongly dependent on the magnitude of the interfacial resistance to heat transfer. This is a possible explanation for discrepancies between the theoretical and experimental results on succinonitrile.

Containment system for experiments on radioactive and other hazardous materials in a Paris-Edinburgh press

DOE PAGES

Jacobsen, M. K.; Velisavljevic, N.

2015-11-20

Recent technical developments using the large volume Paris-Edinburgh press platform have enabled x-ray synchrotron studies at high pressure and temperature conditions. However, its application to some materials of interest, such as high hazard materials that require special handling due to safety issues, reactivity, or other challenges, has not been feasible without the introduction of special containment systems to eliminate the hazards. However, introduction of a containment system is challenging due to the requirement to provide full safety containment for operation in the variety of environments available, while not hindering any of the experimental probes that are available for inert samplemore » measurement. In this work, we report on the development and implementation of a full safety enclosure for a Paris-Edinburgh type press. During the initial development and subsequent application stage of work, experiments were performed on both cerium dioxide (CeO2) and uranium (U). As a result, this device allows for full implementation of all currently available experimental probes involving the Paris-Edinburgh press at the High Pressure Collaborative Access Team sector of the Advanced Photon Source.« less

Overview of Recent Radiation Transport Code Comparisons for Space Applications

NASA Astrophysics Data System (ADS)

Townsend, Lawrence

Recent advances in radiation transport code development for space applications have resulted in various comparisons of code predictions for a variety of scenarios and codes. Comparisons among both Monte Carlo and deterministic codes have been made and published by vari-ous groups and collaborations, including comparisons involving, but not limited to HZETRN, HETC-HEDS, FLUKA, GEANT, PHITS, and MCNPX. In this work, an overview of recent code prediction inter-comparisons, including comparisons to available experimental data, is presented and discussed, with emphases on those areas of agreement and disagreement among the various code predictions and published data.

The finite element method in the deformation and consolidation of porous media

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lewis, R.W.; Schrefler, B.A.

1987-01-01

The authors start with an introduction to the concepts involved in physics giving the equations of flow through porous media and the deformation characteristics of soils and rocks. Succeeding chapters deal with the practical implications of these phenomena and explain the application of theory in both experimental and field work. Details are given of actual incidents, such as the subsidence experienced in Venice and Ravenna. The authors have also formulated a consolidation code, which is detailed at the end of the book, and provide instructions on how to modify the given program.

Microelectronic components and metallic oxide studies and applications

NASA Technical Reports Server (NTRS)

Williams, L., Jr.

1976-01-01

The project involved work in two basic areas: (1) Evaluation of commercial screen printable thick film conductors, resistors, thermistors and dielectrics as well as alumina substrates used in hybird microelectronics industries. Results of tests made on materials produced by seven companies are presented. (2) Experimental studies on metallic oxides of copper and vanadium, in an effort to determine their electrochemical properties in crystalline, powder mixtures and as screen printable thick films constituted the second phase of the research effort. Oxide investigations were aimed at finding possible applications of these materials as switching devices memory elements and sensors.

3D magnetohydrodynamic modelling of a dc low-current plasma arc batch reactor at very high pressure in helium

NASA Astrophysics Data System (ADS)

Lebouvier, A.; Iwarere, S. A.; Ramjugernath, D.; Fulcheri, L.

2013-04-01

This paper deals with a three-dimensional (3D) time-dependent magnetohydrodynamic (MHD) model under peculiar conditions of very high pressures (from 2 MPa up to 10 MPa) and low currents (<1 A). Studies on plasma arc working under these unusual conditions remain almost unexplored because of the technical and technological challenges to develop a reactor able to sustain a plasma at very high pressures. The combined effect of plasma reactivity and high pressure would probably open the way towards new promising applications in various fields: chemistry, lightning, materials or nanomaterial synthesis. A MHD model helps one to understand the complex and coupled phenomena surrounding the plasma which cannot be understood by simply experimentation. The model also provides data which are difficult to directly determine experimentally. The model simulates an experimental-based batch reactor working with helium. The particular reactor in question was used to investigate the Fischer-Tropsch application, fluorocarbon production and CO2 retro-conversion. However, as a first approach in terms of MHD, the model considers the case for helium as a non-reactive working gas. After a detailed presentation of the model, a reference case has been fully analysed (P = 8 MPa, I = 0.35 A) in terms of physical properties. The results show a bending of the arc and displacement of the anodic arc root towards the top of the reactor, due to the combined effects of convection, gravity and electromagnetic forces. A parametric study on the pressure (2-10 MPa) and current (0.25-0.4 A) was then investigated. The operating pressure does not show an influence on the contraction of the arc but higher pressures involve a higher natural convection in the reactor, driven by the density gradients between the cold and hot gas.

Project EX: A Program of Empirical Research on Adolescent Tobacco Use Cessation

PubMed Central

Sussman, Steve; McCuller, William J; Zheng, Hong; Pfingston, Yvonne M; Miyano, James; Dent, Clyde W

2004-01-01

This paper presents the Project EX research program. The historical background for Project EX is presented, including a brief summary of reasons youth fail to quit tobacco use, the disappointing status of previous cessation research, and the teen cessation trial that provided the template for the current project (Project TNT). Next, program development studies for Project EX are described. Through use of focus groups, a theme study (concept evaluation of written activity descriptions), a component study, and pilot studies, an eight-session program was developed. This program involves novel activities (e.g., "talk show enactments," games, and alternative medicine-type activities such as yoga and meditation) in combination with motivation enhancement and cognitive-behavioral strategies to motivate and instruct in cessation initiation and maintenance efforts. The outcomes of the first experimental trial of Project EX, a school-based clinic program, are described, followed by a posthoc analysis of its effects mediation. A second EX study, a multiple baseline single group pilot study design in Wuhan, China, is described next. Description of a second experimental trial follows, which tested EX with nicotine gum versus a natural herb. A third experimental trial that tests a classroom prevention/cessation version of EX is then introduced. Finally, the implications of this work are discussed. The intent-to-treat quit rate for Project EX is approximately 15% across studies, double that of a standard care comparison. Effects last up to a six-month post-program at regular and alternative high schools. Through a systematic protocol of empirical program development and field trials, an effective and replicable model teen tobacco use cessation program is established. Future cessation work might expand on this work.

Project EX: A Program of Empirical Research on Adolescent Tobacco Use Cessation

PubMed Central

Sussman, Steve; McCuller, William J; Zheng, Hong; Pfingston, Yvonne M; Miyano, James; Dent, Clyde W

2004-01-01

This paper presents the Project EX research program. The historical background for Project EX is presented, including a brief summary of reasons youth fail to quit tobacco use, the disappointing status of previous cessation research, and the teen cessation trial that provided the template for the current project (Project TNT). Next, program development studies for Project EX are described. Through use of focus groups, a theme study (concept evaluation of written activity descriptions), a component study, and pilot studies, an eight-session program was developed. This program involves novel activities (e.g., "talk show enactments," games, and alternative medicine-type activities such as yoga and meditation) in combination with motivation enhancement and cognitive-behavioral strategies to motivate and instruct in cessation initiation and maintenance efforts. The outcomes of the first experimental trial of Project EX, a school-based clinic program, are described, followed by a posthoc analysis of its effects mediation. A second EX study, a multiple baseline single group pilot study design in Wuhan, China, is described next. Description of a second experimental trial follows, which tested EX with nicotine gum versus a natural herb. A third experimental trial that tests a classroom prevention/cessation version of EX is then introduced. Finally, the implications of this work are discussed. The intent-to-treat quit rate for Project EX is approximately 15% across studies, double that of a standard care comparison. Effects last up to a six-month post-program at regular and alternative high schools. Through a systematic protocol of empirical program development and field trials, an effective and replicable model teen tobacco use cessation program is established. Future cessation work might expand on this work. PMID:19570278

Experimental Acid Weathering of Fe-Bearing Mars Analog Minerals and Rocks: Implications for Aqueous Origin of Hematite-Bearing Sediments in Meridiani Planum, Mars

NASA Technical Reports Server (NTRS)

Golden, D. C.; Koster, A. M.; Ming, D. W.; Morris, R. V.; Mertzman, S. A.

2011-01-01

A working hypothesis for Meridiani evaporite formation involves the evaporation of fluids derived from acid weathering of Martian basalts and subsequent diagenesis [1, 2]. However, there are no reported experimental studies for the formation of jarosite and gray hematite (spherules), which are characteristic of Meridiani rocks from Mars analog precursor minerals. A terrestrial analog for hematite spherule formation from basaltic rocks under acidic hydrothermal conditions has been reported [3], and we have previously shown that the hematite spherules and jarosite can be synthetically produced in the laboratory using Fe3+ -bearing sulfate brines under hydrothermal conditions [4]. Here we expand and extend these studies by reacting Mars analog minerals with sulfuric acid to form Meridiani-like rock-mineral compositions. The objective of this study is to provide environmental constraints on past aqueous weathering of basaltic materials on Mars.

Spontaneous Scalarization: Dead or Alive?

NASA Astrophysics Data System (ADS)

Berti, Emanuele; Crispino, Luis; Gerosa, Davide; Gualtieri, Leonardo; Horbatsch, Michael; Macedo, Caio; Okada da Silva, Hector; Pani, Paolo; Sotani, Hajime; Sperhake, Ulrich

2015-04-01

In 1993, Damour and Esposito-Farese showed that a wide class of scalar-tensor theories can pass weak-field gravitational tests and exhibit nonperturbative strong-field deviations away from General Relativity in systems involving neutron stars. These deviations are possible in the presence of ``spontaneous scalarization,'' a phase transition similar in nature to spontaneous magnetization in ferromagnets. More than twenty years after the original proposal, binary pulsar experiments have severely constrained the possibility of spontaneous scalarization occurring in nature. I will show that these experimental constraints have important implications for the torsional oscillation frequencies of neutron stars and for the so-called ``I-Love-Q'' relations in scalar-tensor theories. I will also argue that there is still hope to observe strong scalarization effects, despite the strong experimental bounds on the original mechanism. In particular, I will discuss two mechanisms that could produce strong scalarization in neutron stars: anisotropy and multiscalarization. This work was supported by NSF CAREER Award PHY-1055103.

TACT glossary: technoscience.

PubMed

Tambone, V; Pennacchini, M

2010-01-01

The term technoscience (T) indicates the complex interactions between contemporary science and technology, that have become practically inseparable. From an epistemological point of view, T only considers the quantitative knowledge in a reductionist way. Nature has been reduced to a machine that works according to laws learnt through the experimental science. At present, technical efficiency represents an operational dominion on Nature; it gives the power to those who possess it. Scientists, considered as visionaries, have the assignment to lead society. They create new cosmos-visions that are technocentric, thus Ts use the human being as subject of experimentation and they transform some essential dimensions of the human being. All this suggests the necessity of an ethical evaluation of the action integration of different subjects in what we call integrated action. This configuration involves ethical obligations for the agent: he/she has to act preserving and allowing the collaboration, and respecting the professional's individual responsibility.

Disproportionation of rosin on an industrial Pd/C catalyst: reaction pathway and kinetic model discrimination.

PubMed

Souto, Juan Carlos; Yustos, Pedro; Ladero, Miguel; Garcia-Ochoa, Felix

2011-02-01

In this work, a phenomenological study of the isomerisation and disproportionation of rosin acids using an industrial 5% Pd on charcoal catalyst from 200 to 240°C is carried out. Medium composition is determined by elemental microanalysis, GC-MS and GC-FID. Dehydrogenated and hydrogenated acid species molar amounts in the final product show that dehydrogenation is the main reaction. Moreover, both hydrogen and non-hydrogen concentration considering kinetic models are fitted to experimental data using a multivariable non-linear technique. Statistical discrimination among the proposed kinetic models lead to the conclusion hydrogen considering models fit much better to experimental results. The final kinetic model involves first-order isomerisation reactions of neoabietic and palustric acids to abietic acid, first-order dehydrogenation and hydrogenation of this latter acid, and hydrogenation of pimaric acids. Hydrogenation reactions are partial first-order regarding the acid and hydrogen. Copyright © 2010 Elsevier Ltd. All rights reserved.

The Roland Maze Project — Cosmic Ray Registration at Schools

NASA Astrophysics Data System (ADS)

Feder, J.; JȨDRZEJCZAK, K.; Karczmarczyk, J.; Lewandowski, R.; Swarzyński, J.; Szabelska, B.; Szabelski, J.; Tokarski, P.; Wibig, T.

Experimental studies of cosmic rays at the highest energies (above 1018 eV) are the main scientific goal of the projected large area network of extensive air shower detectors. Placing the detectors on the roofs of high school buildings will lower the cost by using the existing urban infrastructure (INTERNET, power supply, etc.), and can be a very efficient way of science popularisation by engaging high school students in the research program. 30 high schools in Łódź are already involved in the project. The project has recently obtained some financial support from the City Council of Łódź. The donation enabled us to start experimental work on detector construction details. A cycle of lectures and seminars devoted to different aspects of project realization (detector construction, on-line data acquisition system, C++ programming) has been organized for students at our Institute and at schools.

Hatching behavior in turtles.

PubMed

Spencer, Ricky-John; Janzen, Fredric J

2011-07-01

Incubation temperature plays a prominent role in shaping the phenotypes and fitness of embryos, including affecting developmental rates. In many taxa, including turtles, eggs are deposited in layers such that thermal gradients alter developmental rates within a nest. Despite this thermal effect, a nascent body of experimental work on environmentally cued hatching in turtles has revealed unexpected synchronicity in hatching behavior. This review discusses environmental cues for hatching, physiological mechanisms behind synchronous hatching, proximate and ultimate causes for this behavior, and future directions for research. Four freshwater turtle species have been investigated experimentally, with hatching in each species elicited by different environmental cues and responding via various physiological mechanisms. Hatching of groups of eggs in turtles apparently involves some level of embryo-embryo communication and thus is not a purely passive activity. Although turtles are not icons of complex social behavior, life-history theory predicts that the group environment of the nest can drive the evolution of environmentally cued hatching.

The materials processing research base of the Materials Processing Center. Report for FY 1982

NASA Technical Reports Server (NTRS)

Flemings, M. C.

1983-01-01

The work described, while involving research in the broad field of materials processing, has two common features: the problems are closed related to space precessing of materials and have both practical and fundamental significance. An interesting and important feature of many of the projects is that the interdisciplinary nature of the problem mandates complementary analytical modeling/experimental approaches. An other important aspect of many of the projects is the increasing use of mathematical modeling techniques as one of the research tools. The predictive capability of these models, when tested against measurements, plays a very important role in both the planning of experimental programs and in the rational interpretation of the results. Many of the projects described have a space experiment as their ultimate objective. Mathematical models are proving to be extremely valuable in projecting the findings of ground - based experiments to microgravity conditions.

Tissue-Informative Mechanism for Wearable Non-invasive Continuous Blood Pressure Monitoring

NASA Astrophysics Data System (ADS)

Woo, Sung Hun; Choi, Yun Young; Kim, Dae Jung; Bien, Franklin; Kim, Jae Joon

2014-10-01

Accurate continuous direct measurement of the blood pressure is currently available thru direct invasive methods via intravascular needles, and is mostly limited to use during surgical procedures or in the intensive care unit (ICU). Non-invasive methods that are mostly based on auscultation or cuff oscillometric principles do provide relatively accurate measurement of blood pressure. However, they mostly involve physical inconveniences such as pressure or stress on the human body. Here, we introduce a new non-invasive mechanism of tissue-informative measurement, where an experimental phenomenon called subcutaneous tissue pressure equilibrium is revealed and related for application in detection of absolute blood pressure. A prototype was experimentally verified to provide an absolute blood pressure measurement by wearing a watch-type measurement module that does not cause any discomfort. This work is supposed to contribute remarkably to the advancement of continuous non-invasive mobile devices for 24-7 daily-life ambulatory blood-pressure monitoring.

Rotational and frictional dynamics of the slamming of a door

NASA Astrophysics Data System (ADS)

Klein, Pascal; Müller, Andreas; Gröber, Sebastian; Molz, Alexander; Kuhn, Jochen

2017-01-01

A theoretical and experimental investigation of the rotational dynamics, including friction, of a slamming door is presented. Based on existing work regarding different damping models for rotational and oscillatory motions, we examine different forms for the (angular) velocity dependence (ωn, n = 0, 1, 2) of the frictional force. An analytic solution is given when all three friction terms are present and several solutions for specific cases known from the literature are reproduced. The motion of a door is investigated experimentally using a smartphone, and the data are compared with the theoretical results. A laboratory experiment under more controlled conditions is conducted to gain a deeper understanding of the movement of a slammed door. Our findings provide quantitative evidence that damping models involving quadratic air drag are most appropriate for the slamming of a door. Examining this everyday example of a physical phenomenon increases student motivation, because they can relate it to their own personal experience.

Modeling of Austenite Grain Growth During Austenitization in a Low Alloy Steel

NASA Astrophysics Data System (ADS)

Dong, Dingqian; Chen, Fei; Cui, Zhenshan

2016-01-01

The main purpose of this work is to develop a pragmatic model to predict austenite grain growth in a nuclear reactor pressure vessel steel. Austenite grain growth kinetics has been investigated under different heating conditions, involving heating temperature, holding time, as well as heating rate. Based on the experimental results, the mathematical model was established by regression analysis. The model predictions present a good agreement with the experimental data. Meanwhile, grain boundary precipitates and pinning effects on grain growth were studied by transmission electron microscopy. It is found that with the increasing of the temperature, the second-phase particles tend to be dissolved and the pinning effects become smaller, which results in a rapid growth of certain large grains with favorable orientation. The results from this study provide the basis for the establishment of large-sized ingot heating specification for SA508-III steel.

Optimization to the Culture Conditions for Phellinus Production with Regression Analysis and Gene-Set Based Genetic Algorithm

PubMed Central

Li, Zhongwei; Xin, Yuezhen; Wang, Xun; Sun, Beibei; Xia, Shengyu; Li, Hui

2016-01-01

Phellinus is a kind of fungus and is known as one of the elemental components in drugs to avoid cancers. With the purpose of finding optimized culture conditions for Phellinus production in the laboratory, plenty of experiments focusing on single factor were operated and large scale of experimental data were generated. In this work, we use the data collected from experiments for regression analysis, and then a mathematical model of predicting Phellinus production is achieved. Subsequently, a gene-set based genetic algorithm is developed to optimize the values of parameters involved in culture conditions, including inoculum size, PH value, initial liquid volume, temperature, seed age, fermentation time, and rotation speed. These optimized values of the parameters have accordance with biological experimental results, which indicate that our method has a good predictability for culture conditions optimization. PMID:27610365

V/STOL and STOL ground effects and testing techniques

NASA Technical Reports Server (NTRS)

Kuhn, R. E.

1987-01-01

The ground effects associated with V/STOL operation were examined and an effort was made to develop the equipment and testing techniques needed for that understanding. Primary emphasis was on future experimental programs in the 40 x 80 and the 80 x 120 foot test sections and in the outdoor static test stand associated with these facilities. The commonly used experimental techniques are reviewed and data obtained by various techniques are compared with each other and with available estimating methods. These reviews and comparisons provide insight into the limitations of past studies and the testing techniques used and identify areas where additional work is needed. The understanding of the flow mechanics involved in hovering and in transition in and out of ground effect is discussed. The basic flow fields associated with hovering, transition and STOL operation of jet powered V/STOL aircraft are depicted.

Towards the Physics of Calcium Signalling in Plants

PubMed Central

Vaz Martins, Teresa; Evans, Matthew J.; Woolfenden, Hugh C.; Morris, Richard J.

2013-01-01

Calcium is an abundant element with a wide variety of important roles within cells. Calcium ions are inter- and intra-cellular messengers that are involved in numerous signalling pathways. Fluctuating compartment-specific calcium ion concentrations can lead to localised and even plant-wide oscillations that can regulate downstream events. Understanding the mechanisms that give rise to these complex patterns that vary both in space and time can be challenging, even in cases for which individual components have been identified. Taking a systems biology approach, mathematical and computational techniques can be employed to produce models that recapitulate experimental observations and capture our current understanding of the system. Useful models make novel predictions that can be investigated and falsified experimentally. This review brings together recent work on the modelling of calcium signalling in plants, from the scale of ion channels through to plant-wide responses to external stimuli. Some in silico results that have informed later experiments are highlighted. PMID:27137393

[Development of an experimental apparatus for energy calibration of a CdTe detector by means of diagnostic X-ray equipment].

PubMed

Fukuda, Ikuma; Hayashi, Hiroaki; Takegami, Kazuki; Konishi, Yuki

2013-09-01

Diagnostic X-ray equipment was used to develop an experimental apparatus for calibrating a CdTe detector. Powder-type samples were irradiated with collimated X-rays. On excitation of the atoms, characteristic X-rays were emitted. We prepared Nb2O5, SnO2, La2O3, Gd2O3, and WO3 metal oxide samples. Experiments using the diagnostic X-ray equipment were carried out to verify the practicality of our apparatus. First, we verified that the collimators involving the apparatus worked well. Second, the X-ray spectra were measured using the prepared samples. Finally, we analyzed the spectra, which indicated that the energy calibration curve had been obtained at an accuracy of ±0.06 keV. The developed apparatus could be used conveniently, suggesting it to be useful for the practical training of beginners and researchers.

X-ray crystallography, an essential tool for the determination of thermodynamic relationships between crystalline polymorphs.

PubMed

Céolin, R; Rietveld, I-B

2016-01-01

After a short review of the controversies surrounding the discovery of crystalline polymorphism in relation to our present day understanding, the methods of how to solve the stability hierarchy of different polymorphs will be briefly discussed. They involve either theoretical calculations, or, more commonly, experimental methods based on classical thermodynamics. The experimental approach is mainly carried out using heat-exchange data associated to the transition of one form into another. It will be demonstrated that work-related data associated to the phase transition should be taken into account and the role of X-ray crystallography therein will be discussed. X-ray crystallography has become increasingly precise and can nowadays provide specific volumes and their differences as a function of temperature, and also as a function of pressure, humidity, and time. Copyright © 2015 Académie Nationale de Pharmacie. Published by Elsevier Masson SAS. All rights reserved.

β-decay half-life of V50 calculated by the shell model

NASA Astrophysics Data System (ADS)

Haaranen, M.; Srivastava, P. C.; Suhonen, J.; Zuber, K.

2014-10-01

In this work we survey the detectability of the β- channel of 2350V leading to the first excited 2+ state in 2450Cr. The electron-capture (EC) half-life corresponding to the transition of 2350V to the first excited 2+ state in 2250Ti had been measured earlier. Both of the mentioned transitions are 4th-forbidden non-unique. We have performed calculations of all the involved wave functions by using the nuclear shell model with the GXPF1A interaction in the full f-p shell. The computed half-life of the EC branch is in good agreement with the measured one. The predicted half-life for the β- branch is in the range ≈2×1019 yr whereas the present experimental lower limit is 1.5×1018 yr. We discuss also the experimental lay-out needed to detect the β--branch decay.

Experimental study designs to improve the evaluation of road mitigation measures for wildlife.

PubMed

Rytwinski, Trina; van der Ree, Rodney; Cunnington, Glenn M; Fahrig, Lenore; Findlay, C Scott; Houlahan, Jeff; Jaeger, Jochen A G; Soanes, Kylie; van der Grift, Edgar A

2015-05-01

An experimental approach to road mitigation that maximizes inferential power is essential to ensure that mitigation is both ecologically-effective and cost-effective. Here, we set out the need for and standards of using an experimental approach to road mitigation, in order to improve knowledge of the influence of mitigation measures on wildlife populations. We point out two key areas that need to be considered when conducting mitigation experiments. First, researchers need to get involved at the earliest stage of the road or mitigation project to ensure the necessary planning and funds are available for conducting a high quality experiment. Second, experimentation will generate new knowledge about the parameters that influence mitigation effectiveness, which ultimately allows better prediction for future road mitigation projects. We identify seven key questions about mitigation structures (i.e., wildlife crossing structures and fencing) that remain largely or entirely unanswered at the population-level: (1) Does a given crossing structure work? What type and size of crossing structures should we use? (2) How many crossing structures should we build? (3) Is it more effective to install a small number of large-sized crossing structures or a large number of small-sized crossing structures? (4) How much barrier fencing is needed for a given length of road? (5) Do we need funnel fencing to lead animals to crossing structures, and how long does such fencing have to be? (6) How should we manage/manipulate the environment in the area around the crossing structures and fencing? (7) Where should we place crossing structures and barrier fencing? We provide experimental approaches to answering each of them using example Before-After-Control-Impact (BACI) study designs for two stages in the road/mitigation project where researchers may become involved: (1) at the beginning of a road/mitigation project, and (2) after the mitigation has been constructed; highlighting real case studies when available. Copyright © 2015 Elsevier Ltd. All rights reserved.

Nonlocality in many-body quantum systems detected with two-body correlators

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tura, J., E-mail: jordi.tura@icfo.es; Augusiak, R.; Sainz, A.B.

Contemporary understanding of correlations in quantum many-body systems and in quantum phase transitions is based to a large extent on the recent intensive studies of entanglement in many-body systems. In contrast, much less is known about the role of quantum nonlocality in these systems, mostly because the available multipartite Bell inequalities involve high-order correlations among many particles, which are hard to access theoretically, and even harder experimentally. Standard, “theorist- and experimentalist-friendly” many-body observables involve correlations among only few (one, two, rarely three...) particles. Typically, there is no multipartite Bell inequality for this scenario based on such low-order correlations. Recently, however,more » we have succeeded in constructing multipartite Bell inequalities that involve two- and one-body correlations only, and showed how they revealed the nonlocality in many-body systems relevant for nuclear and atomic physics [Tura et al., Science 344 (2014) 1256]. With the present contribution we continue our work on this problem. On the one hand, we present a detailed derivation of the above Bell inequalities, pertaining to permutation symmetry among the involved parties. On the other hand, we present a couple of new results concerning such Bell inequalities. First, we characterize their tightness. We then discuss maximal quantum violations of these inequalities in the general case, and their scaling with the number of parties. Moreover, we provide new classes of two-body Bell inequalities which reveal nonlocality of the Dicke states—ground states of physically relevant and experimentally realizable Hamiltonians. Finally, we shortly discuss various scenarios for nonlocality detection in mesoscopic systems of trapped ions or atoms, and by atoms trapped in the vicinity of designed nanostructures.« less

Electro-Analytical Study of Material Interfaces Relevant for Chemical Mechanical Planarization and Lithium Ion Batteries

NASA Astrophysics Data System (ADS)

Turk, Michael C.

This dissertation work involves two areas of experimental research, focusing specifically on the applications of electro-analytical techniques for interfacial material characterization. The first area of the work is centered on the evaluation and characterization of material components used for chemical mechanical planarization (CMP) in the fabrication of semiconductor devices. This part also represents the bulk of the projects undertaken for the present dissertation. The other area of research included here involves exploratory electrochemical studies of certain electrolyte and electrode materials for applications in the development of advanced lithium ion secondary batteries. The common element between the two areas of investigation is the technical approach that combines a broad variety of electro-analytical characterization techniques to examine application specific functions of the associated materials and devices. The CMP related projects concentrate on designing and evaluating materials for CMP slurries that would be useful in the processing of copper interconnects for the sub-22 nm technology node. Specifically, ruthenium and cobalt are nontraditional barrier materials currently considered for the new interconnects. The CMP schemes used to process the structures based on these metals involve complex surface chemistries of Ru, Co and Cu (used for wiring lines). The strict requirement of defect-control while maintaining material removal by precisely regulated tribo-corrosion complicates the designs of the CMP slurries needed to process these systems. Since Ru is electrochemically more noble than Cu, the surface regions of Cu assembled in contact with Ru tend to generate defects due to galvanic corrosion in the CMP environment. At the same time, Co is strongly reactive in the typical slurry environment and is prone to developing galvanic corrosion induced by Cu. The present work explores a selected class of alkaline slurry formulations aimed at reducing these galvanic corrosions in chemically controlled low-pressure CMP. The CMP specific functions of the slurry components are characterized in the tribo-electro-analytical approach by using voltammetry, open circuit potential (OCP) measurements and electrochemical impedance spectroscopy (EIS) in the presence as well as in the absence of surface abrasion, both with and without the inclusion of colloidal silica (SiO2) abrasives. The results are used to understand the reaction mechanisms responsible for supporting material removal and corrosion suppression. The project carried out in the area of Li ion batteries (LIBs) uses electro-analytical techniques to probe electrolyte characteristics as well as electrode material performance. The investigation concentrates on optimizing a tactically chosen set of electrolyte compositions for low-to-moderate temperature applications of lithium titanium oxide (LTO), a relatively new anode material for such batteries. For this application, mixtures of non-aqueous carbonate based solvents are studied in combination with lithium perchlorate. The temperature dependent conductivities of the electrolytes are rigorously measured and analyzed using EIS. The experimental considerations and the working principle of this EIS based approach are carefully examined and standardized in the course of this study. These experiments also investigate the effects of temperature variations (below room temperature) on the solid electrolyte interphase (SEI) formation characteristics of LTO in the given electrolytes. This dissertation is organized as follows: Each experimental system and its relevance for practical applications are briefly introduced in each chapter. The experimental approach and the motivation for carrying out the investigation are also noted in that context. The experimental details specific to the particular study are described. This is followed by the results and their discussion, and subsequently, by the specific conclusions drawn from the given set of experiments. A general summary of the obtained results is presented at the end of the dissertation. Possible extensions of the present studies have also been briefly noted there.

Droplet formation at the non-equilibrium water/water (w/w) interface

NASA Astrophysics Data System (ADS)

Chao, Youchuang; Mak, Sze Yi; Kong, Tiantian; Ding, Zijing; Shum, Ho Cheung

2017-11-01

The interfacial instability at liquid-liquid interfaces has been intensively studied in recent years due to their important role in nature and technology. Among them, two classic instabilities are Rayleigh-Taylor (RT) and double diffusive (DD) instabilities, which are practically relevant to many industrial processes, such as geologic CO2 sequestration. Most experimental and theoretical works have focused on RT or DD instability in binary systems. However, the study of such instability in complex systems, such as non-equilibrium ternary systems that involves mass-transfer-induced phase separation, has received less attention. Here, by using a ternary system known as the aqueous two-phase system (ATPS), we investigate experimentally the behavior of non-equilibrium water/water (w/w) interfaces in a vertically orientated Hele-Shaw cell. We observe that an array of fingers emerge at the w/w interface, and then break into droplets. We explore the instability using different concentrations of two aqueous phases. Our experimental findings are expected to inspire the mass production of all-aqueous emulsions in a simple setup.

Understanding the pseudocapacitance of RuO2 from joint density functional theory

NASA Astrophysics Data System (ADS)

Zhan, Cheng; Jiang, De-en

2016-11-01

Pseudocapacitors have been experimentally studied for many years in electric energy storage. However, first principles understanding of the pseudocapacitive behavior is still not satisfactory due to the complexity involved in modeling electrochemistry. In this paper, we applied joint density functional theory (JDFT) to simulate the pseudocapacitive behavior of RuO2, a prototypical material, in a model electrolyte. We obtained from JDFT a capacitive curve which showed a redox peak position comparable to that in the experimental cyclic voltammetry (CV) curve. We found that the experimental turning point from double-layer to pseudocapacitive charge storage at low scan rates could be explained by the hydrogen adsorption at low coverage. As the electrode voltage becomes more negative, H coverage increases and causes the surface-structure change, leading to bended -OH bonds at the on-top oxygen atoms and large capacitance. This H coverage-dependent capacitance can explain the high pseudocapacitance of hydrous RuO2. Our work here provides a first principles understanding of the pseudocapacitance for RuO2 in particular and for transition-metal oxides in general.

Fantastic plastic? Experimental evaluation of polyurethane bone substitutes as proxies for human bone in trauma simulations.

PubMed

Smith, Martin J; James, Stephen; Pover, Tim; Ball, Nina; Barnetson, Victoria; Foster, Bethany; Guy, Carl; Rickman, John; Walton, Virginia

2015-09-01

Recent years have seen steady improvements in the recognition and interpretation of violence related injuries in human skeletal remains. Such work has at times benefited from the involvement of biological anthropologists in forensic casework and has often relied upon comparison of documented examples with trauma observed in skeletal remains. In cases where no such example exists investigators must turn to experimentation. The selection of experimental samples is problematic as animal proxies may be too dissimilar to humans and human cadavers may be undesirable for a raft of reasons. The current article examines a third alternative in the form of polyurethane plates and spheres marketed as viable proxies for human bone in ballistic experiments. Through subjecting these samples to a range of impacts from both modern and archaic missile weapons it was established that such material generally responds similarly to bone on a broad, macroscopic scale but when examined in closer detail exhibits a range of dissimilarities that call for caution in extrapolating such results to real bone. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

Blade Surface Pressure Distributions in a Rocket Engine Turbine: Experimental Work With On-Blade Pressure Transducers

NASA Technical Reports Server (NTRS)

Hudson, Susan T.; Zoladz, Thomas F.; Griffin, Lisa W.; Turner, James E. (Technical Monitor)

2000-01-01

Understanding the unsteady aspects of turbine rotor flowfields is critical to successful future turbine designs. A technology program was conducted at NASA's Marshall Space Flight Center to increase the understanding of unsteady environments for rocket engine turbines. The experimental program involved instrumenting turbine rotor blades with surface-mounted high frequency response pressure transducers. The turbine model was then tested to measure the unsteady pressures on the rotor blades. The data obtained from the experimental program is unique in three respects. First, much more unsteady data was obtained (several minutes per set point) than has been possible in the past. Also, two independent unsteady data acquisition systems and fundamental signal processing approaches were used. Finally, an extensive steady performance database existed for the turbine model. This allowed an evaluation of the effect of the on-blade instrumentation on the turbine's performance. This unique data set, the lessons learned for acquiring this type of data, and the improvements made to the data analysis and prediction tools will contribute to future turbine programs such as those for reusable launch vehicles.

Characterizing Adhesion between a Micropatterned Surface and a Soft Synthetic Tissue.

PubMed

Kern, Madalyn D; Qi, Yuan; Long, Rong; Rentschler, Mark E

2017-01-31

The work of adhesion and work of separation are characteristic properties of a contact interface that describe the amount of energy per unit area required to adhere or separate two contacting substrates, respectively. In this work, the authors present experimental and data analysis procedures that allow the contact interface between a soft synthetic tissue and a smooth or micropatterned poly(dimethylsiloxane) (PDMS) substrate to be characterized in terms of these characteristic parameters. Because of physical geometry limitations, the experimental contact geometry chosen for this study differs from conventional test geometries. Therefore, the authors used finite element modeling to develop correction factors specific to the experimental contact geometry used in this work. A work of adhesion was directly extracted from experimental data while the work of separation was estimated on the basis of experimental results. These values are compared to other theoretical calculations for validation. The results of this work indicate that the micropatterned PDMS substrate significantly decreases both the work of adhesion and work of separation as compared to a smooth PDMS substrate when in contact with a soft synthetic tissue substrate.

Bayesian inference on multiscale models for poisson intensity estimation: applications to photon-limited image denoising.

PubMed

Lefkimmiatis, Stamatios; Maragos, Petros; Papandreou, George

2009-08-01

We present an improved statistical model for analyzing Poisson processes, with applications to photon-limited imaging. We build on previous work, adopting a multiscale representation of the Poisson process in which the ratios of the underlying Poisson intensities (rates) in adjacent scales are modeled as mixtures of conjugate parametric distributions. Our main contributions include: 1) a rigorous and robust regularized expectation-maximization (EM) algorithm for maximum-likelihood estimation of the rate-ratio density parameters directly from the noisy observed Poisson data (counts); 2) extension of the method to work under a multiscale hidden Markov tree model (HMT) which couples the mixture label assignments in consecutive scales, thus modeling interscale coefficient dependencies in the vicinity of image edges; 3) exploration of a 2-D recursive quad-tree image representation, involving Dirichlet-mixture rate-ratio densities, instead of the conventional separable binary-tree image representation involving beta-mixture rate-ratio densities; and 4) a novel multiscale image representation, which we term Poisson-Haar decomposition, that better models the image edge structure, thus yielding improved performance. Experimental results on standard images with artificially simulated Poisson noise and on real photon-limited images demonstrate the effectiveness of the proposed techniques.

[Protective role of autotypic contacts under cerebellar neural net injury by toxic doses of NO-generative compounds].

PubMed

Samosudova, N V; Reutov, V P; Larionova, N P; Chaĭlakhian, L M

2005-01-01

In the present work, cerebellar neural net injury was induced by toxic doses of NO-generative compound (NaNO2). A protective role of glial cells was revealed in such conditions. The present results were compared with those of the previous work concerning the action of high concentration glutamate on the frog cerebellum (Samosudova et al., 1996). In both cases we observed the appearance of spiral-like structures--"wrappers)"--involving several rows of transformed glial processes with smaller width and bridges connecting the inner sides of row (autotypic contact). A statistic analysis was made according to both previous and present data. We calculated the number and width of rows, and intervals between bridges depending on experimental conditions. As the injury increased (stimulation in the NO-presence), the row number in "wrappers" also increased, while the row width and intervals between bridges decreased. The presence of autotypic contacts in glial "wrappers" enables us to suppose the involvement of adhesive proteins--cadherins in its formation. The obtained data suggested that the formation of spiral structures--"wrappers" may be regarded as a compensative-adaptive reaction on the injury of cerebellar neural net glutamate and NO-generative compounds.

Bioinspired turbine blades offer new perspectives for wind energy

NASA Astrophysics Data System (ADS)

Cognet, V.; Courrech du Pont, S.; Dobrev, I.; Massouh, F.; Thiria, B.

2017-02-01

Wind energy is becoming a significant alternative solution for future energy production. Modern turbines now benefit from engineering expertise, and a large variety of different models exists, depending on the context and needs. However, classical wind turbines are designed to operate within a narrow zone centred around their optimal working point. This limitation prevents the use of sites with variable wind to harvest energy, involving significant energetic and economic losses. Here, we present a new type of bioinspired wind turbine using elastic blades, which passively deform through the air loading and centrifugal effects. This work is inspired from recent studies on insect flight and plant reconfiguration, which show the ability of elastic wings or leaves to adapt to the wind conditions and thereby to optimize performance. We show that in the context of energy production, the reconfiguration of the elastic blades significantly extends the range of operating regimes using only passive, non-consuming mechanisms. The versatility of the new turbine model leads to a large increase of the converted energy rate, up to 35%. The fluid/elasticity mechanisms involved for the reconfiguration capability of the new blades are analysed in detail, using experimental observations and modelling.

Transcription Factors in Long-Term Memory and Synaptic Plasticity

PubMed Central

Alberini, Cristina M.

2013-01-01

Transcription is a molecular requisite for long-term synaptic plasticity and long-term memory formation. Thus, in the last several years, one main interest of molecular neuroscience has been the identification of families of transcription factors that are involved in both of these processes. Transcription is a highly regulated process that involves the combined interaction and function of chromatin and many other proteins, some of which are essential for the basal process of transcription, while others control the selective activation or repression of specific genes. These regulated interactions ultimately allow a sophisticated response to multiple environmental conditions, as well as control of spatial and temporal differences in gene expression. Evidence based on correlative changes in expression, genetic mutations, and targeted molecular inhibition of gene expression have shed light on the function of transcription in both synaptic plasticity and memory formation. This review provides a brief overview of experimental work showing that several families of transcription factors, including CREB, C/EBP, Egr, AP-1, and Rel have essential functions in both processes. The results of this work suggest that patterns of transcription regulation represent the molecular signatures of long-term synaptic changes and memory formation. PMID:19126756

Debates, divisions, and decisions: recombinant DNA advisory committee (RAC) authorization of the first human gene transfer experiments.

PubMed Central

Carmen, I H

1992-01-01

Possibly the most far-reaching, controversial research currently being conducted in the international biological science community involves human gene therapy experimentation. In this paper, I report the dynamics of the political process which ultimately found the Recombinant DNA Advisory Committee (RAC) of the National Institutes of Health approving for the first time protocols of this genre. A full appreciation of the policy-making dialogue shows that significant participants perceived the process from very different vantage points regarding the way in which the American political system works and the way in which it ought to work. I argue that, if we are to understand how the RAC should proceed in orchestrating a human gene therapy policy agenda, then we must flesh out and critically analyze these competing vantage points. To that end, I postulate seven possible "action models" for characterizing how protocol assessments of the type at issue might be developed given the nature of our politics, reaching the conclusion that one of these models holds out the most promise for synthesizing efficaciously the key factors involved. In conclusion, I discuss how the RAC might profitably employ this preferred strategy in these and other cases. PMID:1734711

Interaction between emotion and memory: importance of mammillary bodies damage in a mouse model of the alcoholic Korsakoff syndrome.

PubMed

Béracochéa, Daniel

2005-01-01

Chronic alcohol consumption (CAC) can lead to the Korsakoff syndrome (KS), a memory deficiency attributed to diencephalic damage and/or to medial temporal or cortical related dysfunction. The etiology of KS remains unclear. Most animal models of KS involve thiamine-deficient diets associated with pyrithiamine treatment. Here we present a mouse model of CAC-induced KS. We demonstrate that CAC-generated retrieval memory deficits in working/ episodic memory tasks, together with a reduction of fear reactivity, result from damage to the mammillary bodies (MB). Experimental lesions of MB in non-alcoholic mice produced the same memory and emotional impairments. Drugs having anxiogenic-like properties counteract such impairments produced by CAC or by MB lesions. We suggest (a) that MB are the essential components of a brain network underlying emotional processes, which would be critically important in the retrieval processes involved in working/ episodic memory tasks, and (b) that failure to maintain emotional arousal due to MB damage can be a main factor of CAC-induced memory deficits. Overall, our animal model fits well with general neuropsychological and anatomic impairments observed in KS.

Interaction Between Emotion and Memory: Importance of Mammillary Bodies Damage in a Mouse Model of the Alcoholic Korsakoff Syndrome

PubMed Central

Béracochéa, Daniel

2005-01-01

Chronic alcohol consumption (CAC) can lead to the Korsakoff syndrome (KS), a memory deficiency attributed to diencephalie damage and/or to medial temporal or cortical related dysfunction. The etiology of KS remains unclear. Most animal models of KS involve thiaminedeficient diets associated with pyrithiamine treatment. Here we present a mouse model of CAC-induced KS. We demonstrate that CAC-generated retrieval memory deficits in working/ episodic memory tasks, together with a reduction of fear reactivity, result from damage to the mammillary bodies (MB). Experimental lesions of MB in non-alcoholic mice produced the same memory and emotional impairments. Drugs having anxiogenic-like properties counteract such impairments produced by CAC or by MB lesions. We suggest (a) that MB are the essential components of a brain network underlying emotional processes, which would be critically important in the retrieval processes involved in working/ episodic memory tasks, and (b) that failure to maintain emotional arousal due to MB damage can be a main factor of CAC-induced memory deficits. Overall, our animal model fits well with general neuropsychological and anatomic impairments observed in KS. PMID:16444899

Analytical and experimental investigation of the effects of concrete removal operations on adjacent concrete that is to remain

DOT National Transportation Integrated Search

2002-01-15

This report contains both analytical and experimental work, as well as mathematical work on concrete bridge, located on Route 89 in Vermont. The bridge was renovated by replacing the deck. The experimental work included monitoring the effect of the H...

FY2017 Report on NISC Measurements and Detector Simulations

DOE Office of Scientific and Technical Information (OSTI.GOV)

Andrews, Madison Theresa; Meierbachtol, Krista Cruse; Jordan, Tyler Alexander

FY17 work focused on automation, both of the measurement analysis and comparison of simulations. The experimental apparatus was relocated and weeks of continuous measurements of the spontaneous fission source 252Cf was performed. Programs were developed to automate the conversion of measurements into ROOT data framework files with a simple terminal input. The complete analysis of the measurement (which includes energy calibration and the identification of correlated counts) can now be completed with a documented process which involves one simple execution line as well. Finally, the hurdles of slow MCNP simulations resulting in low simulation statistics have been overcome with themore » generation of multi-run suites which make use of the highperformance computing resources at LANL. Preliminary comparisons of measurements and simulations have been performed and will be the focus of FY18 work.« less

A Realtime Active Feedback Control System For Coupled Nonlinear Chemical Oscillators

NASA Astrophysics Data System (ADS)

Tompkins, Nathan; Fraden, Seth

2012-02-01

We study the manipulation and control of oscillatory networks. As a model system we use an emulsion of Belousov-Zhabotinsky (BZ) oscillators packed on a hexagonal lattice. Each drop is observed and perturbed by a Programmable Illumination Microscope (PIM). The PIM allows us to track individual BZ oscillators, calculate the phase and order parameters of every drop, and selectively perturb specific drops with photo illumination, all in realtime. To date we have determined the native attractor patterns for drops in 1D arrays and 2D hexagonal packing as a function of coupling strength as well as determined methods to move the system from one attractor basin to another. Current work involves implementing these attractor control methods with our experimental system and future work will likely include implementing a model neural network for use with photo controllable BZ emulsions.

Involvement of the European Confederation of the Soil Science Societies in soil protection policy development

NASA Astrophysics Data System (ADS)

Boivin, Pascal

2017-04-01

The European Confederation of the Soil Science Societies (ECSSS) was founded not only to organize the Eurosoil congress, but also to continuously support and promote the soil causes in the European area. A work is in progress to define the best way to achieve this goal, with integrating voices of the European structures and networks, and the national societies. One of the major objectives is to develop a modern approach of soil protection, including leading experimentations shared with all the members, and active lobbying. Such an approach requires the buildup of an efficient interface with policy makers, stake holders, engineering and science, which should be concretized in a new the dimension of the Eurosoil congress. This communication will sketch the on-going work, with reviewing the perspectives, conditions, strengths, questions and difficulties identified.

Building NYX [Engineering Materials

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1988-01-01

From April, 1951, to August 1954, New York Shipbuilding corporation carried out a subcontract with E.I. du Pont de Nemours company that was without parallel in the shipyard's history. The work, designated the NYX Project'' for reasons of security, which was vital to the operations of the Savannah River Plant, Aiken, S.C., which was then being designed and constructed by du Pont for the Atomic Energy Commission. It consisted of three broad parts: Development and experimental work; fabrication and testing of a prototype unit; and fabrication of production units. Five production units were ultimately built, one of them converted frommore » the prototype. All were fabricated from stainless steel, and involved welding techniques, control of thermal distortion and tolerances never previously attempted on assemblies of comparable size. This report provides engineering drawings for this project.« less

Building NYX [Engineering Materials

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1988-12-31

From April, 1951, to August 1954, New York Shipbuilding corporation carried out a subcontract with E.I. du Pont de Nemours & company that was without parallel in the shipyard`s history. The work, designated the ``NYX Project`` for reasons of security, which was vital to the operations of the Savannah River Plant, Aiken, S.C., which was then being designed and constructed by du Pont for the Atomic Energy Commission. It consisted of three broad parts: Development and experimental work; fabrication and testing of a prototype unit; and fabrication of production units. Five production units were ultimately built, one of them convertedmore » from the prototype. All were fabricated from stainless steel, and involved welding techniques, control of thermal distortion and tolerances never previously attempted on assemblies of comparable size. This report provides engineering drawings for this project.« less

Prediction of the acoustic pressure above periodically uneven facings in industrial workplaces

NASA Astrophysics Data System (ADS)

Ducourneau, J.; Bos, L.; Planeau, V.; Faiz, Adil; Skali Lami, Salah; Nejade, A.

2010-05-01

The aim of this work is to predict sound pressure in front of wall facings based on periodic sound scattering surface profiles. The method involves investigating plane wave reflections randomly incident upon an uneven surface. The waveguide approach is well suited to the geometries usually encountered in industrial workplaces. This method simplifies the profile geometry by using elementary rectangular volumes. The acoustic field in the profile interstices can then be expressed as the superposition of waveguide modes. In past work, walls considered are of infinite dimensions and are subjected to a periodic surface profile in only one direction. We therefore generalise this approach by extending its applicability to "double-periodic" wall facings. Free-field measurements have been taken and the observed agreement between numerical and experimental results supports the validity of the waveguide method.

The control of snail hosts of bilharziasis and fascioliasis in Southern Rhodesia.

PubMed

CLARKE, V D; SHIFF, C J; BLAIR, D M

1961-01-01

The authors review the experimental work that has been done since the Second World War on the use of chemical molluscicides in Southern Rhodesia and describe the development of a co-operative snail control campaign involving local landowners and various Government departments. In 1959 and 1960 efforts were concentrated on four large-scale experiments to test the methods of application of copper sulfate, sodium pentachlorophenate and Bayer 73 under a variety of climatic and physiographic conditions.From this work the authors conclude that it would appear possible and practicable to control vector snails in natural water courses and reservoirs in savannah areas of Central Africa to a degree at which it is thought that transmission of bilharziasis from man to man and of fascioliasis from animal to animal does not take place.

The control of snail hosts of bilharziasis and fascioliasis in Southern Rhodesia

PubMed Central

Clarke, V. DE V.; Shiff, C. J.; Blair, D. M.

1961-01-01

The authors review the experimental work that has been done since the Second World War on the use of chemical molluscicides in Southern Rhodesia and describe the development of a co-operative snail control campaign involving local landowners and various Government departments. In 1959 and 1960 efforts were concentrated on four large-scale experiments to test the methods of application of copper sulfate, sodium pentachlorophenate and Bayer 73 under a variety of climatic and physiographic conditions. From this work the authors conclude that it would appear possible and practicable to control vector snails in natural water courses and reservoirs in savannah areas of Central Africa to a degree at which it is thought that transmission of bilharziasis from man to man and of fascioliasis from animal to animal does not take place. PMID:13879773

Delivering the lateral inhibition punchline: it's all about the timing.

PubMed

Axelrod, Jeffrey D

2010-10-26

Experimental and theoretical biologists have long been fascinated with the emergence of self-organizing patterns in developing organisms, and much attention has focused on Notch-mediated lateral inhibition. Within sheets of cells that may adopt either of two possible cell fates, lateral inhibition establishes patterns through the activity of a negative intercellular feedback loop involving the receptor, Notch, and its ligands Delta or Serrate. Despite a long history of intensive study in Drosophila, where the mechanism was first described, as well as in other organisms, new work continues to yield important insights. Mathematical modeling, combined with biological analyses, has now shed light on two features of the process: how antagonistic and activating ligand-receptor interactions work together to accelerate inhibition and ensure fidelity, and how filopodial dynamics contribute to the observed pattern refinement and spacing.

A model for ionic polymer metal composites as sensors

NASA Astrophysics Data System (ADS)

Bonomo, C.; Fortuna, L.; Giannone, P.; Graziani, S.; Strazzeri, S.

2006-06-01

This paper introduces a comprehensive model of sensors based on ionic polymer metal composites (IPMCs) working in air. Significant quantities ruling the sensing properties of IPMC-based sensors are taken into account and the dynamics of the sensors are modelled. A large amount of experimental evidence is given for the excellent agreement between estimations obtained using the proposed model and the observed signals. Furthermore, the effect of sensor scaling is investigated, giving interesting support to the activities involved in the design of sensing devices based on these novel materials. We observed that the need for a wet environment is not a key issue for IPMC-based sensors to work well. This fact allows us to put IPMC-based sensors in a totally different light to the corresponding actuators, showing that sensors do not suffer from the same drawbacks.

Father's role in parent training for children with developmental delay.

PubMed

Bagner, Daniel M

2013-08-01

The current pilot study was a quasi-experimental examination of the impact of father involvement in parent training among 44 families with a young child who presented with elevated externalizing behavior problems and developmental delay. All families were offered to receive Parent-Child Interaction Therapy (PCIT), an evidence-based parent-training intervention, at a hospital-based outpatient clinic. Single-mother families were significantly more likely to drop out of treatment than two-parent families. Of the families that completed treatment, children from families in which a father participated in treatment had lower levels of parent-reported externalizing behavior problems than children from single-mother families and children from two-parent families in which the father did not participate in treatment. Additionally, children from father-involved families were significantly more compliant during a cleanup task than children from single-mother families following treatment. The current study is consistent with the limited research examining father involvement in parent training and extends the findings to children with developmental delay. These findings highlight the importance of involving fathers in parent training, particularly when working with children with developmental delay. © 2013 American Psychological Association

Microstructural evolution in fast-neutron-irradiated austenitic stainless steels

DOE Office of Scientific and Technical Information (OSTI.GOV)

Stoller, R.E.

1987-12-01

The present work has focused on the specific problem of fast-neutron-induced radiation damage to austenitic stainless steels. These steels are used as structural materials in current fast fission reactors and are proposed for use in future fusion reactors. Two primary components of the radiation damage are atomic displacements (in units of displacements per atom, or dpa) and the generation of helium by nuclear transmutation reactions. The radiation environment can be characterized by the ratio of helium to displacement production, the so-called He/dpa ratio. Radiation damage is evidenced microscopically by a complex microstructural evolution and macroscopically by density changes and alteredmore » mechanical properties. The purpose of this work was to provide additional understanding about mechanisms that determine microstructural evolution in current fast reactor environments and to identify the sensitivity of this evolution to changes in the He/dpa ratio. This latter sensitivity is of interest because the He/dpa ratio in a fusion reactor first wall will be about 30 times that in fast reactor fuel cladding. The approach followed in the present work was to use a combination of theoretical and experimental analysis. The experimental component of the work primarily involved the examination by transmission electron microscopy of specimens of a model austenitic alloy that had been irradiated in the Oak Ridge Research Reactor. A major aspect of the theoretical work was the development of a comprehensive model of microstructural evolution. This included explicit models for the evolution of the major extended defects observed in neutron irradiated steels: cavities, Frank faulted loops and the dislocation network. 340 refs., 95 figs., 18 tabs.« less

Using collaborative technologies in remote lab delivery systems for topics in automation

NASA Astrophysics Data System (ADS)

Ashby, Joe E.

Lab exercises are a pedagogically essential component of engineering and technology education. Distance education remote labs are being developed which enable students to access lab facilities via the Internet. Collaboration, students working in teams, enhances learning activity through the development of communication skills, sharing observations and problem solving. Web meeting communication tools are currently used in remote labs. The problem identified for investigation was that no standards of practice or paradigms exist to guide remote lab designers in the selection of collaboration tools that best support learning achievement. The goal of this work was to add to the body of knowledge involving the selection and use of remote lab collaboration tools. Experimental research was conducted where the participants were randomly assigned to three communication treatments and learning achievement was measured via assessments at the completion of each of six remote lab based lessons. Quantitative instruments used for assessing learning achievement were implemented, along with a survey to correlate user preference with collaboration treatments. A total of 53 undergraduate technology students worked in two-person teams, where each team was assigned one of the treatments, namely (a) text messaging chat, (b) voice chat, or (c) webcam video with voice chat. Each had little experience with the subject matter involving automation, but possessed the necessary technical background. Analysis of the assessment score data included mean and standard deviation, confirmation of the homogeneity of variance, a one-way ANOVA test and post hoc comparisons. The quantitative and qualitative data indicated that text messaging chat negatively impacted learning achievement and that text messaging chat was not preferred. The data also suggested that the subjects were equally divided on preference to voice chat verses webcam video with voice chat. To the end of designing collaborative communication tools for remote labs involving automation equipment, the results of this work points to making voice chat the default method of communication; but the webcam video with voice chat option should be included. Standards are only beginning to be developed for the design of remote lab systems. Research, design and innovation involving collaboration and presence should be included.

Aluminum work function: Effect of oxidation, mechanical scraping and ion bombardment

NASA Technical Reports Server (NTRS)

Vinet, P.; Lemogne, T.; Montes, H.

1985-01-01

Surface studies have been performed on aluminum polycrystalline surfaces which have been mechanically scraped. Such studies were initiated in order to understand surface effects occurring in tribological processes which involve rubbing surfaces and the effects of adsorption of oxygen. To characterize the surfaces, the following three different experimental approaches have been used: (1) X.P.S. (X-ray photoelectron spectroscopy), in order to check the cleanliness of the surfaces and follow the adsorption and oxidation kinetics; (2) Analysis of the work function changes by following the energy spectra of secondary electrons emitted under low energy electron bombardment; and (3) Analysis of photoemission intensities under U.V. excitation. The reference state being chosen to be the surface cleaned by ion bombardment and exposures to oxygen atmospheres have been shown to lower the work function of clean polycrystalline aluminum by 1.2 eV. The oxygen pressure is found to affect only the kinetics of these experiments. Mechanical scraping has been shown to induce a decrease ( 0.3 eV) in the work function, which could sharply modify the kinetics of adsorption on the surface.

Promised and delivered inducements and contributions: an integrated view of psychological contract appraisal.

PubMed

Lambert, Lisa Schurer

2011-07-01

The reciprocal exchange of employees' work for pay that is central to employment relationships is viewed here through the lens of the psychological contract. A psychological contract involves promised inducements, promised contributions, delivered inducements, and delivered contributions: How an employee cognitively integrates these 4 elements is a central question in psychological contract theory. Three alternative approaches for integrating the 4 elements were drawn from discrepancy theory, from equity theory, and from need theories of satisfaction, respectively. Experimental findings disconfirmed the discrepancy and equity approaches. Findings were consistent with the premise of the needs model, which is that appraisal is driven by how psychological contract elements facilitate or hinder an employee's effort to fulfill personal needs. Results showed that promised and delivered pay and work contribute uniquely to appraisal but that they vary in their influence on appraisal. These findings were consistent with the needs model principle that elements proximal to need satisfaction matter more than distal elements. That is, what is delivered (for pay and for work) matters more than what is promised, and pay matters more than work.

Effects of Amplitude Variations on Deformation and Damage Evolution in SnAgCu Solder in Isothermal Cycling

NASA Astrophysics Data System (ADS)

Wentlent, Luke; Alghoul, Thaer M.; Greene, Christopher M.; Borgesen, Peter

2018-02-01

Although apparently simpler than in thermal cycling, the behavior of SnAgCu (SAC) solder joints in cyclic bending or vibration is not currently well understood. The rate of damage has been shown to scale with the inelastic work per cycle, and excursions to higher amplitudes lead to an apparent softening, some of which remains so that damage accumulation is faster in subsequent cycling at lower amplitudes. This frequently leads to a dramatic breakdown of current damage accumulation rules. An empirical damage accumulation rule has been proposed to account for this, but any applicability to the extrapolation of accelerated test results to life under realistic long-term service conditions remains to be validated. This will require a better understanding of the underlying mechanisms. The present work provides experimental evidence to support recent suggestions that the observed behavior is a result of cycling-induced dislocation structures providing for increased diffusion creep. It is argued that this means that the measured work is an indicator of the instantaneous dislocation density, rather than necessarily reflecting the actual work involved in the creation of the damage.

Resource scarcity, effort, and performance in physically demanding jobs: An evolutionary explanation.

PubMed

Pitesa, Marko; Thau, Stefan

2018-03-01

Based on evolutionary theory, we predicted that cues of resource scarcity in the environment (e.g., news of droughts or food shortages) lead people to reduce their effort and performance in physically demanding work. We tested this prediction in a 2-wave field survey among employees and replicated it experimentally in the lab. In Study 1, employees who perceived resources in the environment to be scarce reported exerting less effort when their jobs involved much (but not little) physical work. In Study 2, participants who read that resources in the environment were scarce performed worse on a task demanding more (carrying books) but not less (transcribing book titles) physical work. This result was found even though better performance increased participants' chances of additional remuneration, and even though scarcity cues did not affect individuals' actual ability to meet their energy needs. We discuss implications for managing effort and performance, and the potential of evolutionary psychology to explain core organizational phenomena. (PsycINFO Database Record (c) 2018 APA, all rights reserved).

Social Work Field Training for the Community: A Student Self-Directed Approach in the Environmental Domain in Jordan

PubMed Central

Al-Makhamreh, Sahar; Alnabulsi, Hana; Asfour, Hana

2016-01-01

This article outlines innovative field training methods that foster the abilities of undergraduate social work students so that they are able to empower the local community and raise awareness of environmental issues. In this study, students were engaged in a local community assessment that sought to understand their views on environmental and community impacts of the Synchrotron-Light for Experimental Science and Applications in the Middle East (SESAME) Project on the lives of the host village's residents. A students' self-directed approach was applied for the fieldwork out of which interventions were developed ( Garrison, 1997). Quantitative data were gathered by eighteen students through a survey of 361 questionnaires targeting Allan society. In addition to students' field notes, pre and post focus groups were used to collect qualitative information. Study findings highlighted the effectiveness of students' self-directed projects in cultivating culturally competent practices; ensuring sustainable development; and providing evidence-based knowledge on social work practice involving environmental issues. PMID:27559202

Social Work Field Training for the Community: A Student Self-Directed Approach in the Environmental Domain in Jordan.

PubMed

Al-Makhamreh, Sahar; Alnabulsi, Hana; Asfour, Hana

2016-06-01

This article outlines innovative field training methods that foster the abilities of undergraduate social work students so that they are able to empower the local community and raise awareness of environmental issues. In this study, students were engaged in a local community assessment that sought to understand their views on environmental and community impacts of the Synchrotron-Light for Experimental Science and Applications in the Middle East (SESAME) Project on the lives of the host village's residents. A students' self-directed approach was applied for the fieldwork out of which interventions were developed ( Garrison, 1997). Quantitative data were gathered by eighteen students through a survey of 361 questionnaires targeting Allan society. In addition to students' field notes, pre and post focus groups were used to collect qualitative information. Study findings highlighted the effectiveness of students' self-directed projects in cultivating culturally competent practices; ensuring sustainable development; and providing evidence-based knowledge on social work practice involving environmental issues.

Study of development and utilization of a multipurpose atmospheric corrosion sensor

NASA Technical Reports Server (NTRS)

Diwan, Ravinder M.; Raman, A.; Bhattacharya, P. K.

1994-01-01

There has been a critical need for analyzing various aspects of atmospheric corrosion and for the development of atmospheric corrosion microsensors. The project work has involved the following activities: (1) making of multielectrode corrosion monitors on dielectric substrates; (2) testing them in the laboratory for functional characteristics; (3) preparing a report on the state of the art of atmospheric corrosion sensor development around the world; and (4) corrosion testing of electrochemical changes of sensor specimens and related fog testing. The study included work on the subject of development and utilization of a multipurpose atmospheric corrosion sensor and this report is the annual report on work carried out on this research project. This has included studies on the development of sensors of two designs, stage 1 and stage 2, and with glass and alumina substrate, experimentation and development and characterization of the coating uniformity, aspects of corrosion monitoring, literature search on the corrosion sensors and their development. A state of the art report on atmospheric corrosion sensor development was prepared and submitted.

Testing single point incremental forming moulds for rotomoulding operations

NASA Astrophysics Data System (ADS)

Afonso, Daniel; de Sousa, Ricardo Alves; Torcato, Ricardo

2017-10-01

Low pressure polymer processes as thermoforming or rotational moulding use much simpler moulds than high pressure processes like injection. However, despite the low forces involved in the process, moulds manufacturing for these applications is still a very material, energy and time consuming operation. Particularly in rotational moulding there is no standard for the mould manufacture and very different techniques are applicable. The goal of this research is to develop and validate a method for manufacturing plastically formed sheet metal moulds by single point incremental forming (SPIF) for rotomoulding and rotocasting operations. A Stewart platform based SPIF machine allow the forming of thick metal sheets, granting the required structural stiffness for the mould surface, and keeping a short manufacture lead time and low thermal inertia. The experimental work involves the proposal of a hollow part, design and fabrication of a sheet metal mould using dieless incremental forming techniques and testing its operation in the production of prototype parts.

Electron beam interaction with space plasmas.

NASA Astrophysics Data System (ADS)

Krafft, C.; Bolokitin, A. S.

1999-12-01

Active space experiments involving the controlled injection of electron beams and the formation of artificially generated currents can provide in many cases a calibration of natural phenomena connected with the dynamic interaction of charged particles with fields. They have a long history beginning from the launches of small rockets with electron guns in order to map magnetic fields lines in the Earth's magnetosphere or to excite artificial auroras. Moreover, natural beams of charged particles exist in many space and astrophysical plasmas and were identified in situ by several satellites; a few examples are beams connected with solar bursts, planetary foreshocks or suprathermal fluxes traveling in planetary magnetospheres. Many experimental and theoretical works have been performed in order to interpret or plan space experiments involving beam injection as well as to understand the physics of wave-particle interaction, as wave radiation, beam dynamics and background plasma modification.

A kinetic study of xanthohumol cyclization to isoxanthohumol - A role of water

NASA Astrophysics Data System (ADS)

Kamiński, Daniel M.; Gawęda, Karolina; Arczewska, Marta; Senczyna, Bogusław; Gagoś, Mariusz

2017-07-01

Xanthohumol, a major prenylated chalcone found in hop resin, has recently attracted scientific interest due to its health-promoting properties. In the present work, we investigated the mechanism of xanthohumol cyclization to isoxanthohumol in an aqueous solution with a high pH by means of UV-Vis spectroscopy and liquid chromatography. The results were modeled by DFT methods with the SMD solvation model. The results of theoretical calculations were consistent with experimental data. The proposed mechanism comprises two stages, where the first step involves cyclization of xanthohumol ions and the second step involves the addition of H+ ion from a water molecule to an isoxanthohumol ion. The second step is responsible for the stabilization of isoxanthohumol. Based on these results some practical information can be drawn, which may be important from the point of view of the problem xanthohumol stability in commercial dietary supplements.

Comparative genomics of Paracoccus sp. SM22M-07 isolated from coral mucus: insights into bacteria-host interactions.

PubMed

Carlos, Camila; Pereira, Letícia Bianca; Ottoboni, Laura Maria Mariscal

2017-06-01

One of the main goals of coral microbiology is to understand the ways in which coral-bacteria associations are established and maintained. This work describes the sequencing of the genome of Paracoccus sp. SM22M-07 isolated from the mucus of the endemic Brazilian coral species Mussismilia hispida. Comparative analysis was used to identify unique genomic features of SM22M-07 that might be involved in its adaptation to the marine ecosystem and the nutrient-rich environment provided by coral mucus, as well as in the establishment and strengthening of the interaction with the host. These features included genes related to the type IV protein secretion system, erythritol catabolism, and succinoglycan biosynthesis. We experimentally confirmed the production of succinoglycan by Paracoccus sp. SM22M-07 and we hypothesize that it may be involved in the association of the bacterium with coral surfaces.

Multisensory visual servoing by a neural network.

PubMed

Wei, G Q; Hirzinger, G

1999-01-01

Conventional computer vision methods for determining a robot's end-effector motion based on sensory data needs sensor calibration (e.g., camera calibration) and sensor-to-hand calibration (e.g., hand-eye calibration). This involves many computations and even some difficulties, especially when different kinds of sensors are involved. In this correspondence, we present a neural network approach to the motion determination problem without any calibration. Two kinds of sensory data, namely, camera images and laser range data, are used as the input to a multilayer feedforward network to associate the direct transformation from the sensory data to the required motions. This provides a practical sensor fusion method. Using a recursive motion strategy and in terms of a network correction, we relax the requirement for the exactness of the learned transformation. Another important feature of our work is that the goal position can be changed without having to do network retraining. Experimental results show the effectiveness of our method.

Genome-based analysis of heme biosynthesis and uptake in prokaryotic systems.

PubMed

Cavallaro, Gabriele; Decaria, Leonardo; Rosato, Antonio

2008-11-01

Heme is the prosthetic group of many proteins that carry out a variety of key biological functions. In addition, for many pathogenic organisms, heme (acquired from the host) may constitute a very important source of iron. Organisms can meet their heme demands by taking it up from external sources, by producing the cofactor through a dedicated biosynthetic pathway, or both. Here we analyzed the distribution of proteins specifically involved in the processes of heme biosynthesis and heme uptake in 474 prokaryotic organisms. These data allowed us to identify which organisms are capable of performing none, one, or both processes, based on the similarity to known systems. Some specific instances where one or more proteins along the pathways had unusual modifications were singled out. For two key protein domains involved in heme uptake, we could build a series of structural models, which suggested possible alternative modes of heme binding. Future directions for experimental work are given.

Sheet metals characterization using the virtual fields method

NASA Astrophysics Data System (ADS)

Marek, Aleksander; Davis, Frances M.; Pierron, Fabrice

2018-05-01

In this work, a characterisation method involving a deep-notched specimen subjected to a tensile loading is introduced. This specimen leads to heterogeneous states of stress and strain, the latter being measured using a stereo DIC system (MatchID). This heterogeneity enables the identification of multiple material parameters in a single test. In order to identify material parameters from the DIC data, an inverse method called the Virtual Fields Method is employed. The method combined with recently developed sensitivity-based virtual fields allows to optimally locate areas in the test where information about each material parameter is encoded, improving accuracy of the identification over the traditional user-defined virtual fields. It is shown that a single test performed at 45° to the rolling direction is sufficient to obtain all anisotropic plastic parameters, thus reducing experimental effort involved in characterisation. The paper presents the methodology and some numerical validation.

Problems in Microgravity Fluid Mechanics: G-Jitter Convection

NASA Technical Reports Server (NTRS)

Homsy, G. M.

2005-01-01

This is the final report on our NASA grant, Problems in Microgravity Fluid Mechanics NAG3-2513: 12/14/2000 - 11/30/2003, extended through 11/30/2004. This grant was made to Stanford University and then transferred to the University of California at Santa Barbara when the PI relocated there in January 2001. Our main activity has been to conduct both experimental and theoretical studies of instabilities in fluids that are relevant to the microgravity environment, i.e. those that do not involve the action of buoyancy due to a steady gravitational field. Full details of the work accomplished under this grant are given below. Our work has focused on: (i) Theoretical and computational studies of the effect of g-jitter on instabilities of convective states where the convection is driven by forces other than buoyancy (ii) Experimental studies of instabilities during displacements of miscible fluid pairs in tubes, with a focus on the degree to which these mimic those found in immiscible fluids. (iii) Theoretical and experimental studies of the effect of time dependent electrohydrodynamic forces on chaotic advection in drops immersed in a second dielectric liquid. Our objectives are to acquire insight and understanding into microgravity fluid mechanics problems that bear on either fundamental issues or applications in fluid physics. We are interested in the response of fluids to either a fluctuating acceleration environment or to forces other than gravity that cause fluid mixing and convection. We have been active in several general areas.

Jacques Loeb, B. F. Skinner, and the legacy of prediction and control

PubMed Central

Hackenberg, Timothy D.

1995-01-01

The biologist Jacques Loeb is an important figure in the history of behavior analysis. Between 1890 and 1915, Loeb championed an approach to experimental biology that would later exert substantial influence on the work of B. F. Skinner and behavior analysis. This paper examines some of these sources of influence, with a particular emphasis on Loeb's firm commitment to prediction and control as fundamental goals of an experimental life science, and how these goals were extended and broadened by Skinner. Both Loeb and Skinner adopted a pragmatic approach to science that put practical control of their subject matter above formal theory testing, both based their research programs on analyses of reproducible units involving the intact organism, and both strongly endorsed technological applications of basic laboratory science. For Loeb, but especially for Skinner, control came to mean something more than mere experimental or technological control for its own sake; it became synonomous with scientific understanding. This view follows from (a) the successful working model of science Loeb and Skinner inherited from Ernst Mach, in which science is viewed as human social activity, and effective practical action is taken as the basis of scientific knowledge, and (b) Skinner's analysis of scientific activity, situated in the world of direct experience and related to practices arranged by scientific verbal communities. From this perspective, prediction and control are human acts that arise from and are maintained by social circumstances in which such acts meet with effective consequences. PMID:22478220

Comparison between Theoretical Calculation and Experimental Results of Excitation Functions for Production of Relevant Biomedical Radionuclides

NASA Astrophysics Data System (ADS)

Menapace, E.; Birattari, C.; Bonardi, M. L.; Groppi, F.; Morzenti, S.; Zona, C.

2005-05-01

The radionuclide production for biomedical applications has been brought up in the years, as a special nuclear application, at INFN LASA Laboratory, particularly in co-operation with the JRC-Ispra of EC. Mainly scientific aspects concerning radiation detection and the relevant instruments, the measurements of excitation functions of the involved nuclear reactions, the requested radiochemistry studies and further applications have been investigated. On the side of the nuclear data evaluations, based on nuclear model calculations and critically selected experimental data, the appropriate competence has been developed at ENEA Division for Advanced Physics Technologies. A series of high specific activity accelerator-produced radionuclides in no-carrier-added (NCA) form, for uses in metabolic radiotherapy and for PET radiodiagnostics, are investigated. In this work, last revised measurements and model calculations are reviewed for excitation functions of natZn(d,X)64Cu, 66Ga reactions, referring to irradiation experiments at K=38 variable energy Cyclotron of JRC-Ispra. Concerning the reaction data for producing 186gRe and 211At/211gPo (including significant emission spectra) and 210At, most recent and critically selected experimental results are considered and discussed in comparison with model calculations paying special care to pre-equilibrium effects estimate and to the appropriate overall parameterization. Model calculations are presented for 226Ra(p,2n)225Ac reaction, according to the working program of the ongoing IAEA CRP on the matter.

Crystal growth of ZnSe and related ternary compound semiconductors by physical vapor transport

NASA Technical Reports Server (NTRS)

Su, Ching-Hua

1993-01-01

The materials to be investigated are ZnSe and related ternary semiconducting alloys (e.g., ZnS(x)Se(1-x), ZnTe(x)Se(1-x), and Zn(1-x)Cd(x)Se). These materials are useful for opto-electronic applications such as high efficient light emitting diodes and low power threshold and high temperature lasers in the blue-green region of the visible spectrum. The recent demonstration of its optical bistable properties also makes ZnSe a possible candidate material for digital optical computers. The investigation consists of an extensive ground-based study followed by flight experimentation, and involves both experimental and theoretical work. The objectives of the ground-based work are to establish the characteristics of the crystals grown on Earth as a basis for subsequent comparative evaluations of the crystals grown in a low gravity environment and to obtain the experimental data and perform the analyses required to define the optimum parameters for the flight experiments. During the six months of the Preliminary Definition Phase, the research efforts were concentrated on the binary compound ZnSe - the purification of starting materials of Se by zone refining, the synthesis of ZnSe starting materials, the heat treatments of the starting materials, the vapor transport rate measurements, the vapor partial pressure measurements of ZnSe, the crystal growth of ZnSe by physical vapor transport, and various characterization on the grown ZnSe crystals.

Comparison between Theoretical Calculation and Experimental Results of Excitation Functions for Production of Relevant Biomedical Radionuclides

DOE Office of Scientific and Technical Information (OSTI.GOV)

Menapace, E.; Birattari, C.; Bonardi, M.L.

The radionuclide production for biomedical applications has been brought up in the years, as a special nuclear application, at INFN LASA Laboratory, particularly in co-operation with the JRC-Ispra of EC. Mainly scientific aspects concerning radiation detection and the relevant instruments, the measurements of excitation functions of the involved nuclear reactions, the requested radiochemistry studies and further applications have been investigated. On the side of the nuclear data evaluations, based on nuclear model calculations and critically selected experimental data, the appropriate competence has been developed at ENEA Division for Advanced Physics Technologies. A series of high specific activity accelerator-produced radionuclides inmore » no-carrier-added (NCA) form, for uses in metabolic radiotherapy and for PET radiodiagnostics, are investigated. In this work, last revised measurements and model calculations are reviewed for excitation functions of natZn(d,X)64Cu, 66Ga reactions, referring to irradiation experiments at K=38 variable energy Cyclotron of JRC-Ispra. Concerning the reaction data for producing 186gRe and 211At/211gPo (including significant emission spectra) and 210At, most recent and critically selected experimental results are considered and discussed in comparison with model calculations paying special care to pre-equilibrium effects estimate and to the appropriate overall parameterization. Model calculations are presented for 226Ra(p,2n)225Ac reaction, according to the working program of the ongoing IAEA CRP on the matter.« less

Rendering the "Not-So-Simple" Pendulum Experimentally Accessible.

ERIC Educational Resources Information Center

Jackson, David P.

1996-01-01

Presents three methods for obtaining experimental data related to acceleration of a simple pendulum. Two of the methods involve angular position measurements and the subsequent calculation of the acceleration while the third method involves a direct measurement of the acceleration. Compares these results with theoretical calculations and…

Allosteric modulation model of the mu opioid receptor by herkinorin, a potent not alkaloidal agonist

NASA Astrophysics Data System (ADS)

Marmolejo-Valencia, A. F.; Martínez-Mayorga, K.

2017-05-01

Modulation of opioid receptors is the primary choice for pain management and structural information studies have gained new horizons with the recently available X-ray crystal structures. Herkinorin is one of the most remarkable salvinorin A derivative with high affinity for the mu opioid receptor, moderate selectivity and lack of nitrogen atoms on its structure. Surprisingly, binding models for herkinorin are lacking. In this work, we explore binding models of herkinorin using automated docking, molecular dynamics simulations, free energy calculations and available experimental information. Our herkinorin D-ICM-1 binding model predicted a binding free energy of -11.52 ± 1.14 kcal mol-1 by alchemical free energy estimations, which is close to the experimental values -10.91 ± 0.2 and -10.80 ± 0.05 kcal mol-1 and is in agreement with experimental structural information. Specifically, D-ICM-1 molecular dynamics simulations showed a water-mediated interaction between D-ICM-1 and the amino acid H2976.52, this interaction coincides with the co-crystallized ligands. Another relevant interaction, with N1272.63, allowed to rationalize herkinorin's selectivity to mu over delta opioid receptors. Our suggested binding model for herkinorin is in agreement with this and additional experimental data. The most remarkable observation derived from our D-ICM-1 model is that herkinorin reaches an allosteric sodium ion binding site near N1503.35. Key interactions in that region appear relevant for the lack of β-arrestin recruitment by herkinorin. This interaction is key for downstream signaling pathways involved in the development of side effects, such as tolerance. Future SAR studies and medicinal chemistry efforts will benefit from the structural information presented in this work.

First cross-section measurements of the reactions Ag,109107(p ,γ )Cd,110108 at energies relevant to the p process

NASA Astrophysics Data System (ADS)

Khaliel, A.; Mertzimekis, T. J.; Asimakopoulou, E.-M.; Kanellakopoulos, A.; Lagaki, V.; Psaltis, A.; Psyrra, I.; Mavrommatis, E.

2017-09-01

Background: One of the primary objectives of the field of Nuclear Astrophysics is the study of the elemental and isotopic abundances in the universe. Although significant progress has been made in understanding the mechanisms behind the production of a large number of nuclides in the isotopic chart, there are still many open questions regarding a number of neutron-deficient nuclei, the p nuclei. To that end, experimentally deduced nuclear reaction cross sections can provide invaluable input to astrophysical models. Purpose: The reactions Ag,109107(p ,γ )Cd,110108 have been studied at energies inside the astrophysically relevant energy window in an attempt to provide experimental data required for the testing of reaction-rate predictions in terms of the statistical model of Hauser-Feshbach around the p nucleus 108Cd. Methods: The experiments were performed with in-beam γ -ray spectroscopy with proton beams accelerated by the Tandem Van de Graaff Accelerator at NCSR "Demokritos" impinging a target of natural silver. A set of high-purity germanium detectors was employed to record the emitted radiation. Results: A first set of total cross-section measurements in radiative proton-capture reactions involving Ag,109107, producing the p -nucleus 108Cd, inside the astrophysically relevant energy window is reported. The experimental results are compared to theoretical calculations, using talys. An overall good agreement between the data and the theoretical calculations has been found. Conclusions: The results reported in this work add new information to the relatively unexplored p process. The present measurements can serve as a reference point in understanding the nuclear parameters in the related astrophysical environments and for future theoretical modeling and experimental works.

Developments in the field of allergy in 2011 through the eyes of Clinical and Experimental Allergy.

PubMed

Arshad, S H; Dharmage, S C; Ferreira, F; Fixman, E D; Gadermaier, G; Hauser, M; Sampson, A P; Teran, L M; Wallner, M; Wardlaw, A J

2012-12-01

As in previous years, we felt it would be of value to our readership to summarize the new information provided by the authors who have published in Clinical and Experimental Allergy in 2011 and set this in the context of recent advances in our understanding of the pathogenesis and management of allergic disease in all its many manifestations. In 2011, about 210 articles were published in Clinical and Experimental Allergy including editorials, reviews, opinion articles, guidelines, letters, book reviews and of course at the heart of the journal, papers containing original data. As before, this review is divided into sections based on the way the journal is structured, although this year we have grouped together all the papers dealing with mechanisms of allergic disease, whether they involve patients (clinical mechanisms), pure in vitro studies (basic mechanisms) or animal models (experimental models), as we felt this was a more coherent way to deal with the subject. In the field of asthma and rhinitis, the relationship between airway inflammation and airway dysfunction was of perennial interest to investigators, as were phenotypes and biomarkers. Aspirin hypersensitivity appeared in studies in several papers and there was new interest in asthma in the elderly. The mechanisms involved in allergic disease describe advances in our understanding of T cell responses, the relationship between inflammation and disease, mast cell and basophil activation, steroid resistance and novel therapies. In the section dealing with epidemiology, studies seeking to identify risk factors for allergic disease including vitamin D are prominent, as once again are studies investigating gene-environment interactions. The clinical allergy section focuses on drug allergy, food allergy and immunotherapy. The area of oral immunotherapy for food allergy is well covered and we were grateful to Stephen Durham for guest editing an outstanding special issue on immunotherapy in the centenary year of Leonard Noon's pioneering work. Lastly, in the field of allergens, the interest in component-resolved diagnosis continues to grow and there are also articles describing important novel cultivars and the effect of food processing on the allergenic properties of foods. Another terrific year, full of important and high-quality work,which the journal has been proud to bring to the allergy community. © 2012 Blackwell Publishing Ltd.

Independent component model for cognitive functions of multiple subjects using [15O]H2O PET images.

PubMed

Park, Hae-Jeong; Kim, Jae-Jin; Youn, Tak; Lee, Dong Soo; Lee, Myung Chul; Kwon, Jun Soo

2003-04-01

An independent component model of multiple subjects' positron emission tomography (PET) images is proposed to explore the overall functional components involved in a task and to explain subject specific variations of metabolic activities under altered experimental conditions utilizing the Independent component analysis (ICA) concept. As PET images represent time-compressed activities of several cognitive components, we derived a mathematical model to decompose functional components from cross-sectional images based on two fundamental hypotheses: (1) all subjects share basic functional components that are common to subjects and spatially independent of each other in relation to the given experimental task, and (2) all subjects share common functional components throughout tasks which are also spatially independent. The variations of hemodynamic activities according to subjects or tasks can be explained by the variations in the usage weight of the functional components. We investigated the plausibility of the model using serial cognitive experiments of simple object perception, object recognition, two-back working memory, and divided attention of a syntactic process. We found that the independent component model satisfactorily explained the functional components involved in the task and discuss here the application of ICA in multiple subjects' PET images to explore the functional association of brain activations. Copyright 2003 Wiley-Liss, Inc.

Advances in dual-tone development for pitch frequency doubling

NASA Astrophysics Data System (ADS)

Fonseca, Carlos; Somervell, Mark; Scheer, Steven; Kuwahara, Yuhei; Nafus, Kathleen; Gronheid, Roel; Tarutani, Shinji; Enomoto, Yuuichiro

2010-04-01

Dual-tone development (DTD) has been previously proposed as a potential cost-effective double patterning technique1. DTD was reported as early as in the late 1990's2. The basic principle of dual-tone imaging involves processing exposed resist latent images in both positive tone (aqueous base) and negative tone (organic solvent) developers. Conceptually, DTD has attractive cost benefits since it enables pitch doubling without the need for multiple etch steps of patterned resist layers. While the concept for DTD technique is simple to understand, there are many challenges that must be overcome and understood in order to make it a manufacturing solution. Previous work by the authors demonstrated feasibility of DTD imaging for 50nm half-pitch features at 0.80NA (k1 = 0.21) and discussed challenges lying ahead for printing sub-40nm half-pitch features with DTD. While previous experimental results suggested that clever processing on the wafer track can be used to enable DTD beyond 50nm halfpitch, it also suggest that identifying suitable resist materials or chemistries is essential for achieving successful imaging results with novel resist processing methods on the wafer track. In this work, we present recent advances in the search for resist materials that work in conjunction with novel resist processing methods on the wafer track to enable DTD. Recent experimental results with new resist chemistries, specifically designed for DTD, are presented in this work. We also present simulation studies that help and support identifying resist properties that could enable DTD imaging, which ultimately lead to producing viable DTD resist materials.

A survey of urban climate change experiments in 100 cities

PubMed Central

Castán Broto, Vanesa; Bulkeley, Harriet

2013-01-01

Cities are key sites where climate change is being addressed. Previous research has largely overlooked the multiplicity of climate change responses emerging outside formal contexts of decision-making and led by actors other than municipal governments. Moreover, existing research has largely focused on case studies of climate change mitigation in developed economies. The objective of this paper is to uncover the heterogeneous mix of actors, settings, governance arrangements and technologies involved in the governance of climate change in cities in different parts of the world. The paper focuses on urban climate change governance as a process of experimentation. Climate change experiments are presented here as interventions to try out new ideas and methods in the context of future uncertainties. They serve to understand how interventions work in practice, in new contexts where they are thought of as innovative. To study experimentation, the paper presents evidence from the analysis of a database of 627 urban climate change experiments in a sample of 100 global cities. The analysis suggests that, since 2005, experimentation is a feature of urban responses to climate change across different world regions and multiple sectors. Although experimentation does not appear to be related to particular kinds of urban economic and social conditions, some of its core features are visible. For example, experimentation tends to focus on energy. Also, both social and technical forms of experimentation are visible, but technical experimentation is more common in urban infrastructure systems. While municipal governments have a critical role in climate change experimentation, they often act alongside other actors and in a variety of forms of partnership. These findings point at experimentation as a key tool to open up new political spaces for governing climate change in the city. PMID:23805029

Cryptococcus neoformans can form titan-like cells in vitro in response to multiple signals.

PubMed

Trevijano-Contador, Nuria; de Oliveira, Haroldo Cesar; García-Rodas, Rocío; Rossi, Suélen Andreia; Llorente, Irene; Zaballos, Ángel; Janbon, Guilhem; Ariño, Joaquín; Zaragoza, Óscar

2018-05-01

Cryptococcus neoformans is an encapsulated pathogenic yeast that can change the size of the cells during infection. In particular, this process can occur by enlarging the size of the capsule without modifying the size of the cell body, or by increasing the diameter of the cell body, which is normally accompanied by an increase of the capsule too. This last process leads to the formation of cells of an abnormal enlarged size denominated titan cells. Previous works characterized titan cell formation during pulmonary infection but research on this topic has been hampered due to the difficulty to obtain them in vitro. In this work, we describe in vitro conditions (low nutrient, serum supplemented medium at neutral pH) that promote the transition from regular to titan-like cells. Moreover, addition of azide and static incubation of the cultures in a CO2 enriched atmosphere favored cellular enlargement. This transition occurred at low cell densities, suggesting that the process was regulated by quorum sensing molecules and it was independent of the cryptococcal serotype/species. Transition to titan-like cell was impaired by pharmacological inhibition of PKC signaling pathway. Analysis of the gene expression profile during the transition to titan-like cells showed overexpression of enzymes involved in carbohydrate metabolism, as well as proteins from the coatomer complex, and related to iron metabolism. Indeed, we observed that iron limitation also induced the formation of titan cells. Our gene expression analysis also revealed other elements involved in titan cell formation, such as calnexin, whose absence resulted in appearance of abnormal large cells even in regular rich media. In summary, our work provides a new alternative method to investigate titan cell formation devoid the bioethical problems that involve animal experimentation.

Advances in Constraining Solubilities of H-O-C-S-Cl-bearing Fluids in Silicate Melts

NASA Astrophysics Data System (ADS)

Webster, J. D.

2009-12-01

Magmatic-hydrothermal fluids that are variably enriched in the volatile components H2O, CO2/CH4, H2S/SO2, Cl, F, ± B alter rock; dissolve, transport, and deposit ore metals, and drive volcanism. The efficacy of these processes varies directly with the compositions and quantities, and in particular, with the molar volumes of the fluids involved. Although natural hydrothermal fluids are geochemically diverse, experimental constraints on volatile solubilities in silicate melts are largely limited to two volatiles. Recent experimental research, however, has begun to address mutual solubility relationships of three and four volatiles in felsic to intermediate aluminosilicate melts at shallow crustal pressures. Following well-established correlations demonstrating that as little as a few hundred to thousand ppm CO2 or Cl reduce H2O solubility in melts, and hence enhance the tendency for magma to exsolve one or two fluid phases, recent work shows fundamentally important solubility relationships involving H2O, S, and Cl. Research on rhyodacitic (Botcharnikov et al., 2004) and phonolitic melts at 200 MPa reveals that hundreds to thousands of ppm S will reduce Cl solubility in these melts. Thus, S reduces Cl solubility, which in turn reduces H2O solubility in melts. Other investigations have determined that CaSO4 solubility in oxidizing hydrothermal fluids varies directly with the concentrations of NaCl ± KCl in these fluids (Newton and Manning, 2005; Webster et al., 2009). The CaSO4 contents in the most alkali chloride-enriched fluids exceed 60 wt.%. It follows that some mineralizing saline magmatic fluids are strongly enriched in Ca, Na, K, Cl, SO4, and reduced S species. Research on H2O-, CO2-, and Cl-bearing melts at 200 MPa also highlights critical reciprocal volatile solubility behavior. Work at 1200°C on andesitic melts saturated in two fluids determines that the presence of CO2 enlarges the immiscibility gap for vapor plus brine and increases the activities of H2O and Cl (Botcharnikov et al. 2007). Conversely, other work involving Cl-enriched phonolitic melts plus two fluids at 900°C observes that the presence of Cl strongly reduces CO2 solubility in the melt. In fact, for runs containing as much as 80 mole percent CO2 in the fluid, the CO2/CO3 contents of the melts were reduced to values below the limit of detection for FTIR (< ca. 30-40 ppm). Thus, Cl works to reduce CO2 solubility, which in turn reduces H2O solubility in phonolitic melts. Current work on the solubility of H-O-C-S in haplogranitic melts at 200 MPa demonstrates that the addition of C reduces the (fluid/melt) partition coefficient for S. In addition, these experimentally determined partition coefficients decrease in the order CO2 > S > H2O, and their ranges are virtually identical to and thus confirm modeled values computed (Scaillet and Pichavant, 2003) for pre-eruptive magmatic fluids based on volatile fugacities of volcanic gases of arc-related magmas. Botcharnikov R et al (2004) Chem. Geol. 213, 207-225. Botcharnikov R, Holtz F, Behrens H (2007) Eur. J. Mineral. 19, 671-680. Newton R, Manning C (2005) J. Petrol. 46, 701-716. Scaillet B, Pichavant M (2003) Volcanic Degassing, Geol. Soc. Spec. Pub. 213, 23-52. Webster J, Sintoni M, De Vivo B (2009) Chem. Geol. 263, 19-36.

5 CFR 595.103 - What requirements must agencies establish for determining which physician positions are covered?

Code of Federal Regulations, 2011 CFR

2011-01-01

... research and experimental work, including the conduct of medical work pertaining to food, drugs, cosmetics, and devices (or the review or evaluation of such medical research and experimental work), or the... medical research and experimental programs. (c) The agency head may establish as separate categories any...

5 CFR 595.103 - What requirements must agencies establish for determining which physician positions are covered?

Code of Federal Regulations, 2014 CFR

2014-01-01

... research and experimental work, including the conduct of medical work pertaining to food, drugs, cosmetics, and devices (or the review or evaluation of such medical research and experimental work), or the... medical research and experimental programs. (c) The agency head may establish as separate categories any...

5 CFR 595.103 - What requirements must agencies establish for determining which physician positions are covered?

Code of Federal Regulations, 2013 CFR

2013-01-01

... research and experimental work, including the conduct of medical work pertaining to food, drugs, cosmetics, and devices (or the review or evaluation of such medical research and experimental work), or the... medical research and experimental programs. (c) The agency head may establish as separate categories any...

5 CFR 595.103 - What requirements must agencies establish for determining which physician positions are covered?

Code of Federal Regulations, 2012 CFR

2012-01-01

... research and experimental work, including the conduct of medical work pertaining to food, drugs, cosmetics, and devices (or the review or evaluation of such medical research and experimental work), or the... medical research and experimental programs. (c) The agency head may establish as separate categories any...

Breakup of loosely bound nuclei at intermediate energies for nuclear astrophysics and the development of a position sensitive microstrip detector system and its readout electronics using ASICs technologies

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tribble, Robert E.; Sobotka, Lee G.; Blackmon, Jeff C.

2015-12-29

The work performed under this grant has led to the development of a detection system that will be used to measure reaction rates for proton or neutron capture reactions at stellar energies on radioactive ions far from stability. The reaction rates are needed to better understand the physics of nucleosynthesis in explosive stellar processes such as supernovae and x-ray burst events. The radioactive ions will be produced at the Radioactive Ion Beam Facility (RIBF) at RIKEN near Tokyo, Japan. During the course of this work, the group involved in this project has expanded by several institutions in Europe and Japanmore » and now involves collaborators from the U.S., Japan, Hungary, Romania, Germany, Spain, Italy, China, and South Korea. As part of the project, a novel design based on large-area silicon detectors has been built and tested and the performance characterized in a series of tests using particle beams with a variety of atomic numbers at the Cyclotron Institute of Texas A&M University and the Heavy Ion Medical Accelerator in Chiba facility (HIMAC) in Chiba, Japan. The work has involved mechanical construction of a special purpose vacuum chamber, with a precision mounting system for the silicon detectors, development of a new ASICs readout system that has applications with a wide variety of silicon detector systems, and the development of a data acquisition system that is integrated into the computer system being used at RIBF. The parts noted above that are needed to carry out the research program are completed and ready for installation. Several approved experiments that will use this system will be carried out in the near future. The experimental work has been delayed due to a large increase in the cost and availability of electrical power for RIBF that occurred following the massive earthquake and tsunami that hit Japan in the spring of 2011. Another component of the research carried out with this grant involved developing the theoretical tools that are required to extract the information from the experiments that is needed to determine the stellar reaction rates. The tools developed through this part of the work will be made freely available for general use.« less

DOE Office of Scientific and Technical Information (OSTI.GOV)

Meadows, J.; Smith, D.; Greenwood, L.

Four sample packets containing elemental Ti, Fe, Ni, Cu, Nb, Ag, Eu, Tb and Hf have been irradiated in three distinct accelerator neutron fields, at Argonne National Laboratory and Los Alamos National Laboratory, USA, and Japan Atomic Energy Research Institute, Tokai, Japan. The acquired experimental data include differential cross sections and integral cross sections for the continuum neutron spectrum produced by 7-MeV deuterons incident on thick Be-metal target. The U-238(n,f) cross section was also measured at 10.3 MeV as a consistency check on the experimental technique. This the third progress report on a project which has been carried out undermore » the auspices of an IAEA Coordinated Research Program entitled ``Activation Cross Sections for the Generation Of Long-lived Radionuclides of Importance in Fusion Reactor Technology``. The present report provides the latest results from this work. Comparison is made between the 14.7-MeV cross-section values obtained from the separate investigations at Argonne and JAERI. Generally, good agreement observed within the experimental errors when consistent sample parameters, radioactivity decay data and reference cross values are employed. A comparison is also made between the experimental results and those derived from calculations using a nuclear model. Experimental neutron information on the Be(d,n) neutron spectrum was incorporated in the comparisons for the integral results. The agreement is satisfactory considering the various uncertainties that are involved.« less

The Implications of Contamination for Educational Experiments with Two Levels of Nesting

ERIC Educational Resources Information Center

Rhoads, Christopher

2016-01-01

Experimental evaluations that involve the educational system usually involve a hierarchical structure (students are nested within classrooms that are nested within schools, etc.). Concerns about contamination, where research subjects receive certain features of an intervention intended for subjects in a different experimental group, have often led…

Student Involvement in Learning and School Achievement.

ERIC Educational Resources Information Center

Anderson, Lorin W.

The purpose of the study was to investigate the relationship between selected student characteristics, student involvement in learning, and achievement. Both naturalistic (n = 28, 27) and experimental studies were conducted. In the experimental study, two classes (n = 29, 26) learned a sequence of matrix arithmetic by mastery learning strategies.…

Computational modeling of RNA 3D structures, with the aid of experimental restraints

PubMed Central

Magnus, Marcin; Matelska, Dorota; Łach, Grzegorz; Chojnowski, Grzegorz; Boniecki, Michal J; Purta, Elzbieta; Dawson, Wayne; Dunin-Horkawicz, Stanislaw; Bujnicki, Janusz M

2014-01-01

In addition to mRNAs whose primary function is transmission of genetic information from DNA to proteins, numerous other classes of RNA molecules exist, which are involved in a variety of functions, such as catalyzing biochemical reactions or performing regulatory roles. In analogy to proteins, the function of RNAs depends on their structure and dynamics, which are largely determined by the ribonucleotide sequence. Experimental determination of high-resolution RNA structures is both laborious and difficult, and therefore, the majority of known RNAs remain structurally uncharacterized. To address this problem, computational structure prediction methods were developed that simulate either the physical process of RNA structure formation (“Greek science” approach) or utilize information derived from known structures of other RNA molecules (“Babylonian science” approach). All computational methods suffer from various limitations that make them generally unreliable for structure prediction of long RNA sequences. However, in many cases, the limitations of computational and experimental methods can be overcome by combining these two complementary approaches with each other. In this work, we review computational approaches for RNA structure prediction, with emphasis on implementations (particular programs) that can utilize restraints derived from experimental analyses. We also list experimental approaches, whose results can be relatively easily used by computational methods. Finally, we describe case studies where computational and experimental analyses were successfully combined to determine RNA structures that would remain out of reach for each of these approaches applied separately. PMID:24785264

Rethinking 3R strategies: Digging deeper into AnimalTestInfo promotes transparency in in vivo biomedical research

PubMed Central

Dörendahl, Antje; Leich, Nora; Vietze, Julia; Steinfath, Matthias; Chmielewska, Justyna; Hensel, Andreas; Grune, Barbara; Schönfelder, Gilbert

2017-01-01

In the European Union (EU), animal welfare is seen as a matter of great importance. However, with respect to animal experimentation, European citizens feel quite uninformed. The European Directive 2010/63/EU for the protection of laboratory animals aims for greater transparency and requires that a comprehensible, nontechnical summary (NTS) of each authorised research project involving animals is published by the respective Member State. However, the NTSs remain sleeping beauties if their contents are not easily and systematically accessible. The German web-based NTS database AnimalTestInfo is a unique channel for scientists to communicate their work, and provides the opportunity for large-scale analyses of planned animal studies to inform researchers and the public. For an in-depth meta-analysis, we classified the duly completed NTSs submitted to AnimalTestInfo in 2014 and 2015 according to the International Classification of Diseases and Related Health Problems (ICD) system. Indexing the NTSs with ICD codes provided a fine-grained overview of the prospective uses of experimental animals. Using this approach, transparency, especially for highly controversial animal research involving, for example, nonhuman primates, is fostered, as it enables pinpointing the envisaged beneficiary down to the level of the addressed disease. Moreover, research areas with many planned projects involving animals can be specified in detail. The development of 3R (replacement, reduction, and refinement) measures in these research areas may be most efficient, as a large number of experimental animals would benefit from it. Indexing NTSs with ICD codes can support governments and funding agencies in advancing target-oriented funding of 3R research. Data drawn from NTSs can provide a basis for the development, validation, and implementation of directed 3R strategies as well as guidance for rethinking the role of animal research models. PMID:29240762

Understanding the bond-energy, hardness, and adhesive force from the phase diagram via the electron work function

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lu, Hao; Huang, Xiaochen; Li, Dongyang, E-mail: dongyang.li@ualberta.ca

2014-11-07

Properties of metallic materials are intrinsically determined by their electron behavior. However, relevant theoretical treatment involving quantum mechanics is complicated and difficult to be applied in materials design. Electron work function (EWF) has been demonstrated to be a simple but fundamental parameter which well correlates properties of materials with their electron behavior and could thus be used to predict material properties from the aspect of electron activities in a relatively easy manner. In this article, we propose a method to extract the electron work functions of binary solid solutions or alloys from their phase diagrams and use this simple approachmore » to predict their mechanical strength and surface properties, such as adhesion. Two alloys, Fe-Ni and Cu-Zn, are used as samples for the study. EWFs extracted from phase diagrams show same trends as experimentally observed ones, based on which hardness and surface adhesive force of the alloys are predicted. This new methodology provides an alternative approach to predict material properties based on the work function, which is extractable from the phase diagram. This work may also help maximize the power of phase diagram for materials design and development.« less

Consideration of Alternate Working Fluid Properties in Gas Lubricated Foil Journal Bearings

NASA Technical Reports Server (NTRS)

Smith, Matthew J.

2004-01-01

The Oil-Free Turbomachinery Program at the NASA Glenn Research center is committed to, revolutionary improvements in performance, efficiency and reliability of turbomachinery propulsion systems. One of the key breakthroughs by which this goal is being achieved is the maturation of air lubricated foil bearing technology. Through experimental testing, foil bearings have demonstrated a variety of exceptional qualities that show them to have an important role in the future of rotordynamic lubrication. Most of the work done with foil bearings thus far has considered ambient air at atmospheric pressure as the working fluid or lubricating fluid in the bearing. However, special applications of oil-free technology require the use of air at non- standard ambient conditions or completely different working fluids altogether. The NASA Jupiter Icy Moon Orbiter program presents power generation needs far beyond that of any previous space exploration effort. The proposed spacecraft will require significant power generation to provide the propulsion necessary to reach the moons of Jupiter and navigate between them. Once there, extensive scientific research will be conducted that will also present significant power requirements. Such extreme needs require exploring a new method for power generation in space. A proposed solution involves a Brayton cycle nuclear fission reactor. The nature of this application requires reliable performance of all reactor components for many years of operation under demanding conditions. This includes the bearings which will be operating with an alternative working fluid that is a combination of Helium and Xenon gases commonly known as HeXe. This fluid has transport and thermal properties that vary significantly from that of air and the effect of these property differences on bearing performance must be considered. One of the most promising applications of oil-free technology is in aircraft turbine engines. Eliminating the oil supply systems from aircraft engines will lead to significant weight and maintenance reduction. In such applications, the lubricating fluid will be high altitude air. This air will be at much lower pressure than that at sea level. Again this property change will result in a change in bearing performance, and analysis is required to quantify this effect. The study of these alternate working fluid properties will be conducted in two ways: analytically and experimentally. Analytical research will include the use of a mathematical code that can predict film thickness profiles for various ambient conditions. Estimations of load capacity can be made based upon the film thickness trends. These values will then be compared to those obtained from classical rigid bearing analysis. Experimental Research will include testing a foil bearing at a variety of ambient air pressures. The analytical and experimental data will be compared to draw conclusions on bearing performance under alternate working fluid properties.

[Return to work of a pacemaker bearing worker: the relationship between health problems and electromagnetic interferences].

PubMed

Taino, G; Frigerio, F

2004-01-01

The potential effects of electromagnetic fields is a problem that interest the public opinion, as the modern society expose all people to electromagnetic non ionizing radiations. The problem has a particular and important meaning facing the return to normal life and work conditions of a cardiopatic subject bearing a pacemaker (PM) or implantable cardioverter defibrillator (ICD). Electromagnetic interferences can produce temporary or permanent malfunctions in these devices. Checking for the absence of electromagnetic interferences is necessary considering that correct functioning of these medical devices is essential for the life of the bearer. Precautions normally adopted by these subjects are generally adequate to ensure protection from interferences present in life environment; for occupational environment, there is often lack of adequate information, also due to late involving of the doctor specialist in occupational health. This work intends to study in depth a specific job, a carpentry-workshop with welding activities, starting with a case of a PM bearer who asked a doctor specialist in occupational health to evaluate the problems involved in his return to work. Electric and magnetic fields produced by equipments present in the workshop were measured and compared to data supplied by the literature to evaluate the possibility of interactions in the normally functioning of implanted electronic devices. On the basis of our experience, we have found some criterions for specific risk assessement to adopt for the definition of operative protocols for return to work of PM or ICD carriers, also considering the lack of specific procedures and indications for the doctor specialist in occupational health. The collected information and data from the literature suggest that welding can be a risk for a subject with PM; as observed in experimental conditions, electromagnetic radiations can alter particular sensitive devices and those with uncorrected settings.

Recent Experiments Involving Few-Nucleon Systems

NASA Astrophysics Data System (ADS)

Tornow, W.

2014-08-01

Recent experimental results are presented for reactions involving A = 3 to A = 6 nuclear systems. The emphasis is on unique data obtained at new experimental facilities. It is shown that the inertial confinement fusion facilities OMEGA and NIF provide a largely unexpected opportunity for experimental few-body physics to both obtain data of unprecedented quality and extend previous measurements to energies not accessible in the past. Whenever possible, data are compared to state-of-the-art theoretical calculations.

A Dyadic Interactive Approach to the Study of Leader Behavior

DTIC Science & Technology

1975-07-01

supervisors and workers in a bogus greeting card company performed experimental tasks involving construction of " origami " cranes. The following variables...comprised of a supervisor and three workers who, in turn, were assigned the task of producing " origami " paper cranes and were paid on a piece-rate basis...behaviors as he inter- acted with his followers. Experimental Task The experimental task involved the construction of " origami " cranes from sheets of

Reactive Fluid Flow and Applications to Diagenesis, Mineral Deposits, and Crustal Rocks

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rye, Danny M.; Bolton, Edward W.

2002-11-04

The objective is to initiate new: modeling of coupled fluid flow and chemical reactions of geologic environments; experimental and theoretical studies of water-rock reactions; collection and interpretation of stable isotopic and geochemical field data at many spatial scales of systems involving fluid flow and reaction in environments ranging from soils to metamorphic rocks. Theoretical modeling of coupled fluid flow and chemical reactions, involving kinetics, has been employed to understand the differences between equilibrium, steady-state, and non-steady-state behavior of the chemical evolution of open fluid-rock systems. The numerical codes developed in this project treat multi-component, finite-rate reactions combined with advective andmore » dispersive transport in multi-dimensions. The codes incorporate heat, mass, and isotopic transfer in both porous and fractured media. Experimental work has obtained the kinetic rate laws of pertinent silicate-water reactions and the rates of Sr release during chemical weathering. Ab-initio quantum mechanical techniques have been applied to obtain the kinetics and mechanisms of silicate surface reactions and isotopic exchange between water and dissolved species. Geochemical field-based studies were carried out on the Wepawaug metamorphic schist, on the Irish base-metal sediment-hosted ore system, in the Dalradian metamorphic complex in Scotland, and on weathering in the Columbia River flood basalts. The geochemical and isotopic field data, and the experimental and theoretical rate data, were used as constraints on the numerical models and to determine the length and time scales relevant to each of the field areas.« less

32 CFR 537.15 - Statutory authority for maritime claims and claims involving civil works of a maritime nature.

Code of Federal Regulations, 2010 CFR

2010-07-01

... claims involving civil works of a maritime nature. 537.15 Section 537.15 National Defense Department of....15 Statutory authority for maritime claims and claims involving civil works of a maritime nature. (a... affirmative claims involving civil works of a maritime nature is set out at 33 U.S.C. 408. ...

32 CFR 537.15 - Statutory authority for maritime claims and claims involving civil works of a maritime nature.

Code of Federal Regulations, 2011 CFR

2011-07-01

... claims involving civil works of a maritime nature. 537.15 Section 537.15 National Defense Department of....15 Statutory authority for maritime claims and claims involving civil works of a maritime nature. (a... affirmative claims involving civil works of a maritime nature is set out at 33 U.S.C. 408. ...

32 CFR 537.15 - Statutory authority for maritime claims and claims involving civil works of a maritime nature.

Code of Federal Regulations, 2014 CFR

2014-07-01

... claims involving civil works of a maritime nature. 537.15 Section 537.15 National Defense Department of....15 Statutory authority for maritime claims and claims involving civil works of a maritime nature. (a... affirmative claims involving civil works of a maritime nature is set out at 33 U.S.C. 408. ...

32 CFR 537.15 - Statutory authority for maritime claims and claims involving civil works of a maritime nature.

Code of Federal Regulations, 2013 CFR

2013-07-01

... claims involving civil works of a maritime nature. 537.15 Section 537.15 National Defense Department of....15 Statutory authority for maritime claims and claims involving civil works of a maritime nature. (a... affirmative claims involving civil works of a maritime nature is set out at 33 U.S.C. 408. ...

32 CFR 537.15 - Statutory authority for maritime claims and claims involving civil works of a maritime nature.

Code of Federal Regulations, 2012 CFR

2012-07-01

... claims involving civil works of a maritime nature. 537.15 Section 537.15 National Defense Department of....15 Statutory authority for maritime claims and claims involving civil works of a maritime nature. (a... affirmative claims involving civil works of a maritime nature is set out at 33 U.S.C. 408. ...

Theoretical and Experimental Investigation of the Stability of an Evaporating Constrained Vapor Bubble

NASA Technical Reports Server (NTRS)

Wayner, P. C., Jr.; Plawsky, J. L.; Wong, Harris

2004-01-01

The major accomplishments of the experimental portion of the research were documented in Ling Zheng's doctoral dissertation. Using Pentane, he obtained a considerable amount of data on the stability and heat transfer characteristics of an evaporating meniscus. The important points are that experimental equipment to obtain data on the stability and heat transfer characteristics of an evaporating meniscus were built and successfully operated. The data and subsequent analyses were accepted by the Journal of Heat Transfer for publication in 2004 [PU4]. The work was continued by a new graduate student using HFE-7000 [PU3] and then Pentane at lower heat fluxes. The Pentane results are being analyzed for publication. The experimental techniques are currently being used in our other NASA Grant. The oscillation of the contact line observed in the experiments involves evaporation (retraction part) and spreading. Since both processes occur with finite contact angles, it is important to derive a precise equation of the intermolecular forces (disjoining pressure) valid for non-zero contact angles. This theoretical derivation was accepted for publication by Journal of Fluid Mechanics [PU5]. The evaporation process near the contact line is complicated, and an idealized micro heat pipe has been proposed to help in elucidating the detailed evaporation process [manuscripts in preparation].

Geo-material microfluidics at reservoir conditions for subsurface energy resource applications

DOE PAGES

Porter, Mark L.; Jiménez-Martínez, Joaquín; Martinez, Ricardo Martin; ...

2015-08-20

Microfluidic investigations of flow and transport in porous and fractured media have the potential to play a significant role in the development of future subsurface energy resource technologies. However, the majority of experimental systems to date are limited in applicability due to operating conditions and/or the use of engineered material micromodels. In this paper, we have developed a high pressure and temperature microfluidic experimental system that allows for direct observations of flow and transport within geo-material micromodels (e.g. rock, cement) at reservoir conditions. In this manuscript, we describe the experimental system, including our novel micromodel fabrication method that works inmore » both geo- and engineered materials and utilizes 3-D tomography images of real fractures as micromodel templates to better represent the pore space and fracture geometries expected in subsurface formations. We present experimental results that highlight the advantages of using real-rock micromodels and discuss potential areas of research that could benefit from geo-material microfluidic investigations. Finally, the experiments include fracture–matrix interaction in which water imbibes into the shale rock matrix from etched fractures, supercritical CO 2 (scCO 2) displacing brine in idealized and realistic fracture patterns, and three-phase flow involving scCO 2–brine–oil.« less

Assessment of radiation shield integrity of DD/DT fusion neutron generator facilities by Monte Carlo and experimental methods

NASA Astrophysics Data System (ADS)

Srinivasan, P.; Priya, S.; Patel, Tarun; Gopalakrishnan, R. K.; Sharma, D. N.

2015-01-01

DD/DT fusion neutron generators are used as sources of 2.5 MeV/14.1 MeV neutrons in experimental laboratories for various applications. Detailed knowledge of the radiation dose rates around the neutron generators are essential for ensuring radiological protection of the personnel involved with the operation. This work describes the experimental and Monte Carlo studies carried out in the Purnima Neutron Generator facility of the Bhabha Atomic Research Center (BARC), Mumbai. Verification and validation of the shielding adequacy was carried out by measuring the neutron and gamma dose-rates at various locations inside and outside the neutron generator hall during different operational conditions both for 2.5-MeV and 14.1-MeV neutrons and comparing with theoretical simulations. The calculated and experimental dose rates were found to agree with a maximum deviation of 20% at certain locations. This study has served in benchmarking the Monte Carlo simulation methods adopted for shield design of such facilities. This has also helped in augmenting the existing shield thickness to reduce the neutron and associated gamma dose rates for radiological protection of personnel during operation of the generators at higher source neutron yields up to 1 × 1010 n/s.

The Alkaline Hydrolysis of Sulfonate Esters: Challenges in Interpreting Experimental and Theoretical Data

PubMed Central

2013-01-01

Sulfonate ester hydrolysis has been the subject of recent debate, with experimental evidence interpreted in terms of both stepwise and concerted mechanisms. In particular, a recent study of the alkaline hydrolysis of a series of benzene arylsulfonates (Babtie et al., Org. Biomol. Chem.10, 2012, 8095) presented a nonlinear Brønsted plot, which was explained in terms of a change from a stepwise mechanism involving a pentavalent intermediate for poorer leaving groups to a fully concerted mechanism for good leaving groups and supported by a theoretical study. In the present work, we have performed a detailed computational study of the hydrolysis of these compounds and find no computational evidence for a thermodynamically stable intermediate for any of these compounds. Additionally, we have extended the experimental data to include pyridine-3-yl benzene sulfonate and its N-oxide and N-methylpyridinium derivatives. Inclusion of these compounds converts the Brønsted plot to a moderately scattered but linear correlation and gives a very good Hammett correlation. These data suggest a concerted pathway for this reaction that proceeds via an early transition state with little bond cleavage to the leaving group, highlighting the care that needs to be taken with the interpretation of experimental and especially theoretical data. PMID:24279349

Deposition and clearance of inhaled particles.

PubMed Central

Stuart, B O

1984-01-01

Theoretical models of respiratory tract deposition of inhaled particles are compared to experimental studies of deposition patterns in humans and animals, as governed principally by particle size, density, respiratory rate and flow parameters. Various models of inhaled particle deposition make use of approximations of the respiratory tract to predict fractional deposition caused by fundamental physical processes of particle impaction, sedimentation, and diffusion. These models for both total deposition and regional (nasopharyngeal, tracheobronchial, and pulmonary) deposition are compared with early and recent experimental studies. Reasonable correlation has been obtained between theoretical and experimental studies, but the behavior in the respiratory tract of very fine (less than 0.1 micron) particles requires further investigation. Properties of particle shape, charge and hygroscopicity as well as the degree of respiratory tract pathology also influence deposition patterns; definitive experimental work is needed in these areas. The influence upon deposition patterns of dynamic alterations in inspiratory flow profiles caused by a variety of breathing patterns also requires further study, and the use of differing ventilation techniques with selected inhaled particle sizes holds promise in diagnosis of respiratory tract diseases. Mechanisms of conducting airway and alveolar clearance processes involving the pulmonary macrophage, mucociliary clearance, dissolution, transport to systemic circulation, and translocation via regional lymphatic vessels are discussed. PMID:6376108

Weak Long-Range Correlated Motions in a Surface Patch of Ubiquitin Involved in Molecular Recognition

PubMed Central

2011-01-01

Long-range correlated motions in proteins are candidate mechanisms for processes that require information transfer across protein structures, such as allostery and signal transduction. However, the observation of backbone correlations between distant residues has remained elusive, and only local correlations have been revealed using residual dipolar couplings measured by NMR spectroscopy. In this work, we experimentally identified and characterized collective motions spanning four β-strands separated by up to 15 Å in ubiquitin. The observed correlations link molecular recognition sites and result from concerted conformational changes that are in part mediated by the hydrogen-bonding network. PMID:21634390

Zeno effect in spontaneous decay induced by coupling to an unstable level

NASA Astrophysics Data System (ADS)

Luis, Alfredo

2001-09-01

A metastable atomic level can be rendered unstable in a controllable way by coupling it to a decaying state. In this work we carry out a full dynamical analysis of the Zeno effect in this kind of unstable systems, comparing it to the inhibition of purely coherent Rabi oscillations. Simple and experimentally feasible measuring strategies involving three atomic levels are considered. It is shown that this induced decay is actually an example of a partial Zeno effect so that the observed evolution results from the competition of two Zeno effects. We also show that a three-level scheme can display both coherent, incoherent, and anti-Zeno effects.

The history of neurosurgical treatment of sports concussion.

PubMed

Stone, James L; Patel, Vimal; Bailes, Julian E

2014-10-01

Concussion has a long and interesting history spanning at least the 5 millennia of written medical record and closely mirrors the development of surgery and neurosurgery. Not surprisingly, much of the past and present experimental head injury and concussion work has been performed within neurosurgically driven laboratories or by several surgically oriented neurologists. This historical review chronicles the key aspects of neurosurgical involvement in sports concussion as related to the diagnosis, treatment, mitigation, and prevention of injury using the example of American football. In addition, we briefly trace the developments that led to our current understanding of the biomechanical and neurophysiological basis of concussion.

The mixing of particle clouds plunging into water

DOE Office of Scientific and Technical Information (OSTI.GOV)

Angelini, S.; Theofanous, T.G.; Yuen, W.W.

This work addresses certain fundamental aspects of the premixing phase of steam explosions, At issue are the multifield interaction aspects under highly transient, multidimensional conditions, and in presence of strong phase changes. They are addressed in an experiment (the MAGICO-2000) involving well-characterized particle clouds mixing with water, and detailed measurements on both external and internal characteristics of the mixing zone. Both cold and hot (up to 1500{degrees}C) particle clouds are considered in conjunction with saturated and subcooled water pools. The PMALPHA code is used as an aid in interpreting the experimental results, and the exercise reveals good predictive capabilities formore » it.« less

Guidelines for managing data and processes in bone and cartilage tissue engineering.

PubMed

Viti, Federica; Scaglione, Silvia; Orro, Alessandro; Milanesi, Luciano

2014-01-01

In the last decades, a wide number of researchers/clinicians involved in tissue engineering field published several works about the possibility to induce a tissue regeneration guided by the use of biomaterials. To this aim, different scaffolds have been proposed, and their effectiveness tested through in vitro and/or in vivo experiments. In this context, integration and meta-analysis approaches are gaining importance for analyses and reuse of data as, for example, those concerning the bone and cartilage biomarkers, the biomolecular factors intervening in cell differentiation and growth, the morphology and the biomechanical performance of a neo-formed tissue, and, in general, the scaffolds' ability to promote tissue regeneration. Therefore standards and ontologies are becoming crucial, to provide a unifying knowledge framework for annotating data and supporting the semantic integration and the unambiguous interpretation of novel experimental results. In this paper a conceptual framework has been designed for bone/cartilage tissue engineering domain, by now completely lacking standardized methods. A set of guidelines has been provided, defining the minimum information set necessary for describing an experimental study involved in bone and cartilage regenerative medicine field. In addition, a Bone/Cartilage Tissue Engineering Ontology (BCTEO) has been developed to provide a representation of the domain's concepts, specifically oriented to cells, and chemical composition, morphology, physical characterization of biomaterials involved in bone/cartilage tissue engineering research. Considering that tissue engineering is a discipline that traverses different semantic fields and employs many data types, the proposed instruments represent a first attempt to standardize the domain knowledge and can provide a suitable means to integrate data across the field.

E-Learning System for Experiments Involving Construction of Practical Electronic Circuits

ERIC Educational Resources Information Center

Takemura, Atsushi

2013-01-01

This paper proposes a novel e-learning system for technical experiments involving the construction of practical electronic circuits; this system would meet the various demands of individual experimenters. This mixed mode is beneficial for practical use in that an experimenter who does not have sufficient circuit components for circuit making can…

A Minimal Regulatory Network of Extrinsic and Intrinsic Factors Recovers Observed Patterns of CD4+ T Cell Differentiation and Plasticity

PubMed Central

Martinez-Sanchez, Mariana Esther; Mendoza, Luis; Villarreal, Carlos; Alvarez-Buylla, Elena R.

2015-01-01

CD4+ T cells orchestrate the adaptive immune response in vertebrates. While both experimental and modeling work has been conducted to understand the molecular genetic mechanisms involved in CD4+ T cell responses and fate attainment, the dynamic role of intrinsic (produced by CD4+ T lymphocytes) versus extrinsic (produced by other cells) components remains unclear, and the mechanistic and dynamic understanding of the plastic responses of these cells remains incomplete. In this work, we studied a regulatory network for the core transcription factors involved in CD4+ T cell-fate attainment. We first show that this core is not sufficient to recover common CD4+ T phenotypes. We thus postulate a minimal Boolean regulatory network model derived from a larger and more comprehensive network that is based on experimental data. The minimal network integrates transcriptional regulation, signaling pathways and the micro-environment. This network model recovers reported configurations of most of the characterized cell types (Th0, Th1, Th2, Th17, Tfh, Th9, iTreg, and Foxp3-independent T regulatory cells). This transcriptional-signaling regulatory network is robust and recovers mutant configurations that have been reported experimentally. Additionally, this model recovers many of the plasticity patterns documented for different T CD4+ cell types, as summarized in a cell-fate map. We tested the effects of various micro-environments and transient perturbations on such transitions among CD4+ T cell types. Interestingly, most cell-fate transitions were induced by transient activations, with the opposite behavior associated with transient inhibitions. Finally, we used a novel methodology was used to establish that T-bet, TGF-β and suppressors of cytokine signaling proteins are keys to recovering observed CD4+ T cell plastic responses. In conclusion, the observed CD4+ T cell-types and transition patterns emerge from the feedback between the intrinsic or intracellular regulatory core and the micro-environment. We discuss the broader use of this approach for other plastic systems and possible therapeutic interventions. PMID:26090929

Biodeterioration of the Cement Composites

NASA Astrophysics Data System (ADS)

Luptáková, Alena; Eštoková, Adriana; Mačingová, Eva; Kovalčíková, Martina; Jenčárová, Jana

2016-10-01

The destruction of natural and synthetic materials is the spontaneous and irreversible process of the elements cycling in nature. It can by accelerated or decelerated by physical, chemical and biological influences. Biological influences are represented by the influence of the vegetation and microorganisms (MO). The destruction of cement composites by different MO through the diverse mechanisms is entitled as the concrete biodeterioration. Several sulphur compounds and species of MO are involved in this complex process. Heterotrophic and chemolithotrophic bacteria together with fungi have all been found in samples of corroding cement composites. The MO involved in the process metabolise the presented sulphur compounds (hydrogen sulphide, elemental sulphur etc.) to sulphuric acid reacting with concrete. When sulphuric acid reacts with a concrete matrix, the first step involves a reaction between the acid and the calcium hydroxide forming calcium sulphate. This is subsequently hydrated to form gypsum, the appearance of which on the surface of concrete pipes takes the form of a white, mushy substance which has no cohesive properties. In the continuing attack, the gypsum would react with the calcium aluminate hydrate to form ettringite, an expansive product. The use supplementary cementing composite materials have been reported to improve the resistance of concrete to biodeterioration. The aim of this work was the study of the cement composites biodeterioration by the bacteria Acidithiobacillus thiooxidans. Experimental works were focused on the comparison of special cement composites and its resistance affected by the activities of used sulphur-oxidising

Design of a factorial experiment with randomization restrictions to assess medical device performance on vascular tissue.

PubMed

Diestelkamp, Wiebke S; Krane, Carissa M; Pinnell, Margaret F

2011-05-20

Energy-based surgical scalpels are designed to efficiently transect and seal blood vessels using thermal energy to promote protein denaturation and coagulation. Assessment and design improvement of ultrasonic scalpel performance relies on both in vivo and ex vivo testing. The objective of this work was to design and implement a robust, experimental test matrix with randomization restrictions and predictive statistical power, which allowed for identification of those experimental variables that may affect the quality of the seal obtained ex vivo. The design of the experiment included three factors: temperature (two levels); the type of solution used to perfuse the artery during transection (three types); and artery type (two types) resulting in a total of twelve possible treatment combinations. Burst pressures of porcine carotid and renal arteries sealed ex vivo were assigned as the response variable. The experimental test matrix was designed and carried out as a split-plot experiment in order to assess the contributions of several variables and their interactions while accounting for randomization restrictions present in the experimental setup. The statistical software package SAS was utilized and PROC MIXED was used to account for the randomization restrictions in the split-plot design. The combination of temperature, solution, and vessel type had a statistically significant impact on seal quality. The design and implementation of a split-plot experimental test-matrix provided a mechanism for addressing the existing technical randomization restrictions of ex vivo ultrasonic scalpel performance testing, while preserving the ability to examine the potential effects of independent factors or variables. This method for generating the experimental design and the statistical analyses of the resulting data are adaptable to a wide variety of experimental problems involving large-scale tissue-based studies of medical or experimental device efficacy and performance.

Electronic structure of O-doped SiGe calculated by DFT + U method

NASA Astrophysics Data System (ADS)

Zhao, Zong-Yan; Yang, Wen; Yang, Pei-Zhi

2016-12-01

To more in depth understand the doping effects of oxygen on SiGe alloys, both the micro-structure and properties of O-doped SiGe (including: bulk, (001) surface, and (110) surface) are calculated by DFT + U method in the present work. The calculated results are as follows. (i) The (110) surface is the main exposing surface of SiGe, in which O impurity prefers to occupy the surface vacancy sites. (ii) For O interstitial doping on SiGe (110) surface, the existences of energy states caused by O doping in the band gap not only enhance the infrared light absorption, but also improve the behaviors of photo-generated carriers. (iii) The finding about decreased surface work function of O-doped SiGe (110) surface can confirm previous experimental observations. (iv) In all cases, O doing mainly induces the electronic structures near the band gap to vary, but is not directly involved in these variations. Therefore, these findings in the present work not only can provide further explanation and analysis for the corresponding underlying mechanism for some of the experimental findings reported in the literature, but also conduce to the development of μc-SiGe-based solar cells in the future. Project supported by the Natural Science Foundation of Yunnan Province, China (Grant No. 2015FB123), the 18th Yunnan Province Young Academic and Technical Leaders Reserve Talent Project, China (Grant No. 2015HB015), and the National Natural Science Foundation of China (Grant No. U1037604).

Rational design of a carboxylic esterase RhEst1 based on computational analysis of substrate binding

DOE PAGES

Chen, Qi; Luan, Zheng -Jiao; Yu, Hui -Lei; ...

2015-10-31

A new carboxylic esterase RhEst1 which catalyzes the hydrolysis of (S)-(+)-2,2-dimethylcyclopropanecarboxylate (S-DmCpCe), the key chiral building block of cilastatin, was identified and subsequently crystallized in our previous work. Mutant RhEst 1A147I/V148F/G254A was found to show a 5-fold increase in the catalytic activity. In this work, molecular dynamic simulations were performed to elucidate the molecular determinant of the enzyme activity. Our simulations show that the substrate binds much more strongly in the A147I/V148F/G254A mutant than in wild type, with more hydrogen bonds formed between the substrate and the catalytic triad and the oxyanion hole. The OH group of the catalytic residuemore » Ser101 in the mutant is better positioned to initiate the nucleophilic attack on S-DmCpCe. Interestingly, the "170-179" loop which is involved in shaping the catalytic sites and facilitating the product release shows remarkable dynamic differences in the two systems. Based on the simulation results, six residues were identified as potential "hot-spots" for further experimental testing. Consequently, the G126S and R133L mutants show higher catalytic efficiency as compared with the wild type. In conclusion, this work provides molecular-level insights into the substrate binding mechanism of carboxylic esterase RhEst1, facilitating future experimental efforts toward developing more efficient RhEst1 variants for industrial applications.« less

Pulsed-Laser-Induced Melting and Solidification of Thin Metallic Films

NASA Astrophysics Data System (ADS)

Choi, Min Hwan

This thesis focused on investigating excimer-laser induced melting and solidification of thin metallic films on SiO2. Two distinct topics were pursued: (1) microstructural manipulation and optimization of Cu films via SLS of as-deposited Cu films on SiO2, and (2) investigation of oriented heterogeneous nucleation via complete melting and subsequent nucleation-initated solidification of Ni films on SiO2. Close examination of laterally grown grains, which quickly develop rolling direction crystallographic orientation texture due to occlusion of differently oriented grains, reveal, furthermore, that low-angle grain boundaries as well as twins can be generated during the growth. These intra-grain defects are found to appear in a systematic manner (as they are located at specific regions and observed under specific incident energy densities). Significantly longer lateral growth distances observed in Cu films (compared to that of Si films) was attributed to the fact that substantially higher growth rates are expected with simple metallic films at a given interfacial undercooling. The implementation of SLS using Cu films was accomplished quite effectively, as can be expected from the above lateral-growth-related results involving single-shot expeirments. We were able to achieve a variety of large-grained, grain-boundary location and grain-orientation controlled Cu films via various SLS techniques. When performed optimally in accordance with the findings made in chapter 2, the resulting microstructure exhibits large grains, which are primarily devoid of intra-grain defects. For example, 2-shot SLS processed Cu films led to strong rolling direction orientation, while avoiding the formation of low-angle grain boundaries and twin-boundaries. The highlight of SLS on Cu films correspond to a version of SLS (referred to as "2-Shot plus 2-Shot" SLS) in which the second 2-shot SLS is performed in the direction perpendicular to the first one. Through this approach, we were able to achieve grain-boundary-location controlled microstructure with a strong orientation texture in all three dimensions (forming, effectively, an ultra-large quasi-single crystal material). Nucleation of solids in laser-quenched Ni films was investigated using EBSD analysis. The surface orientation analysis of nucleated grains obtained within the complete melting regime reveal a clear sign of texture. From these and additional findings from previous work involving Al films, we were able to conclude that systematic heterogeneous nucleation has taken place, and, furthermore, that oriented nucleation of the solids must have taken place. Although always suspected to be the case, it is typically extremely challenging to prove with certainty, in conventional nucleation experiments, that the mechanism of nucleation corresponds to that of a heterogeneous one. Furthermore, although it has been suspected theoretically for over 50 years, experimental results that clearly show that oriented nucleation actually transpires have not been obtained until our work involving Al films; the present findings involving Ni films further strengthen this conclusion as the Ni system removes some of the experimental uncertainties that are associated with Al films, and, furthermore, suggests that the process of oriented nucleation is a general and rather pervasive phenomenon. Additionally, it was observed that the selected orientation changed as a function of incident energy density; in the low energy density regime (above the completed melting threshold) {110}-surface texture was observed, while {111}-surface texture became more dominent at higher densities. Motivated by our experimental work involving Al and Ni that clearly indicates that oriented heterogeneous nucleation is a major path through which heterogeneous nucleation of solids occurs, we have also carried out a 2-dimensional Winterbottom-type thermodynamic analysis that can be used to obtain a better understanding of the phenomenon. In contrast to the previous work on the subject, we consider in our modelling the anisotropic nature of both the solid-liquid and solid-substrate interfacial energy; we advocate that this is the only physically consistent combination. The results show that oriented nucleation can be systematically accounted for as stemming from the expected anisotropic nature of the involved interfacial energies. Furthermore, the analysis also suggests possible reasons for observing a transition in surface texture from one orientation to another. (Abstract shortened by UMI.).

Effects of new ways of working on work hours and work location, health and job-related outcomes.

PubMed

Nijp, Hylco H; Beckers, Debby G J; van de Voorde, Karina; Geurts, Sabine A E; Kompier, Michiel A J

2016-01-01

New ways of working (NWW) is a type of work organization that is characterized by temporal and spatial flexibility, often combined with extensive use of information and communication technologies (ICT) and performance-based management. In a three-wave intervention study, we examined the effects of NWW on both the organization of work (changes in control over time and place of work; working hours and work location; and other key job characteristics), and on employees' outcomes (work-nonwork balance; health and well-being; and job-related outcomes). We applied a quasi-experimental design within a large Dutch financial company (N = 2,912). We studied an intervention group (n = 2,391) and made comparisons with a reference group (n = 521). There were three study waves: (i) one/two months before, and (ii) 4 months and (iii) 10 months after implementation of NWW. Repeated measures analyses of covariance (involving 361 participants from the intervention group and 80 participants from the reference group) showed a large and significant shift from hours worked at the office to hours worked at home after implementation of NWW. Accordingly, commuting time was reduced. Employees remained working on week days and during day time. Psychosocial work-characteristics, work-nonwork balance, stress, fatigue, and job-related outcomes remained favourable and largely unaffected, but the health score in the intervention group decreased (medium effect). These findings suggest that the implementation of NWW does not necessarily lead to changes in psychosocial work characteristics, well-being or job-related outcomes.

University of Oklahoma - High Energy Physics

DOE Office of Scientific and Technical Information (OSTI.GOV)

Skubic, Patrick L.

2013-07-31

The High Energy Physics program at the University of Oklahoma, Pat Skubic, Principal Investigator, is attempting to understand nature at the deepest level using the most advanced experimental and theoretical tools. The four experimental faculty, Brad Abbott, Phil Gutierrez, Pat Skubic, and Mike Strauss, together with post-doctoral associates and graduate students, are finishing their work as part of the D0 collaboration at Fermilab, and increasingly focusing their investigations at the Large Hadron Collidor (LHC) as part of the ATLAS Collaboration. Work at the LHC has become even more exciting with the recent discovery by ATLAS and the other collaboration, CMS,more » of the long-sought Higgs boson, which plays a key role in generating masses for the elementary constituents of matter. Work of the OUHEP group has been in the three areas of hardware, software, and analysis. Now that the Higgs boson has been discovered, completing the Standard Model of fundamental physics, new efforts will focus on finding hints of physics beyond the standard model, such as supersymmetry. The OUHEP theory group (Kim Milton, PI) also consists of four faculty members, Howie Baer, Chung Kao, Kim Milton, and Yun Wang, and associated students and postdocs. They are involved in understanding fundamental issues in formulating theories of the microworld, and in proposing models that carry us past the Standard Model, which is an incomplete description of nature. They therefore work in close concert with their experimental colleagues. One also can study fundamental physics by looking at the large scale structure of the universe; in particular the ``dark energy'' that seems to be causing the universe to expand at an accelerating rate, effectively makes up about 3/4 of the energy in the universe, and yet is totally unidentified. Dark energy and dark matter, which together account for nearly all of the energy in the universe, are an important probe of fundamental physics at the very shortest distances, or at the very highest energies. The outcomes of the group's combined experimental and theoretical research will be an improved understanding of nature, at the highest energies reachable, from which applications to technological innovation will surely result, as they always have from such studies in the past.« less

Night-shift work and breast cancer risk in a cohort of Chinese women.

PubMed

Pronk, Anjoeka; Ji, Bu-Tian; Shu, Xiao-Ou; Xue, Shouzheng; Yang, Gong; Li, Hong-Lan; Rothman, Nathaniel; Gao, Yu-Tang; Zheng, Wei; Chow, Wong-Ho

2010-05-01

Shift work involving disruption of circadian rhythms has been classified as a probable cause of human cancer by the International Agency for Research on Cancer, based on limited epidemiologic evidence and abundant experimental evidence. The authors investigated this association in a population-based prospective cohort study of Chinese women. At baseline (1996-2000), information on lifetime occupational history was obtained from 73,049 women. Lifetime night-shift exposure indices were created using a job exposure matrix. During 2002-2004, self-reported data on frequency and duration of night-shift work were collected. Hazard ratios and 95% confidence intervals, adjusted for major breast cancer risk factors, were calculated. During follow-up through 2007, 717 incident cases of breast cancer were diagnosed. Breast cancer risk was not associated with ever working the night shift on the basis of the job exposure matrix (adjusted hazard ratio = 1.0, 95% confidence interval: 0.9, 1.2) or self-reported history of night-shift work (adjusted hazard ratio = 0.9, 95% confidence interval: 0.7, 1.1). Risk was also not associated with frequency, duration, or cumulative amount of night-shift work. There were no indications of effect modification. The lack of an association between night-shift work and breast cancer adds to the inconsistent epidemiologic evidence. It may be premature to consider shift work a cause of cancer.

Working memory involved in predicting future outcomes based on past experiences.

PubMed

Dretsch, Michael N; Tipples, Jason

2008-02-01

Deficits in working memory have been shown to contribute to poor performance on the Iowa Gambling Task [IGT: Bechara, A., & Martin, E.M. (2004). Impaired decision making related to working memory deficits in individuals with substance addictions. Neuropsychology, 18, 152-162]. Similarly, a secondary memory load task has been shown to impair task performance [Hinson, J., Jameson, T. & Whitney, P. (2002). Somatic markers, working memory, and decision making. Cognitive, Affective, & Behavioural Neuroscience, 2, 341-353]. In the present study, we investigate whether the latter findings were due to increased random responding [Franco-Watkins, A. M., Pashler, H., & Rickard, T. C. (2006). Does working memory load lead to greater impulsivity? Commentary on Hinson, Jameson, and Whitney's (2003). Journal of Experimental Psychology: Learning, Memory & Cognition, 32, 443-447]. Participants were tested under Low Working Memory (LWM; n=18) or High Working Memory (HWM; n=17) conditions while performing the Reversed IGT in which punishment was immediate and reward delayed [Bechara, A., Dolan, S., & Hindes, A. (2002). Decision making and addiction (part II): Myopia for the future or hypersensitivity to reward? Neuropsychologia, 40, 1690-1705]. In support of a role for working memory in emotional decision making, compared to the LWM condition, participants in the HWM condition made significantly greater number of disadvantageous selections than that predicted by chance. Performance by the HWM group could not be fully explained by random responding.

Diagnostics of Carbon Nanotube Formation in a Laser Produced Plume: An Investigation of the Metal Catalyst by Laser Ablation Atomic Fluorescence Spectroscopy

NASA Technical Reports Server (NTRS)

deBoer, Gary; Scott, Carl

2003-01-01

Carbon nanotubes, elongated molecular tubes with diameters of nanometers and lengths in microns, hold great promise for material science. Hopes for super strong light-weight material to be used in spacecraft design is the driving force behind nanotube work at JSC. The molecular nature of these materials requires the appropriate tools for investigation of their structure, properties, and formation. The mechanism of nanotube formation is of particular interest because it may hold keys to controlling the formation of different types of nanotubes and allow them to be produced in much greater quantities at less cost than is currently available. This summer's work involved the interpretation of data taken last summer and analyzed over the academic year. The work involved diagnostic studies of carbon nanotube formation processes occurring in a laser-produced plume. Laser ablation of metal doped graphite to produce a plasma plume in which carbon nanotubes self assemble is one method of making carbon nanotube. The laser ablation method is amenable to applying the techniques of laser spectroscopy, a powerful tool for probing the energies and dynamics of atomic and molecular species. The experimental work performed last summer involved probing one of the metal catalysts, nickel, by laser induced fluorescence. The nickel atom was studied as a function of oven temperature, probe laser wavelength, time after ablation, and position in the laser produced plume. This data along with previously obtained data on carbon was analyzed over the academic year. Interpretations of the data were developed this summer along with discussions of future work. The temperature of the oven in which the target is ablated greatly influences the amount of material ablated and the propagation of the plume. The ablation conditions and the time scale of atomic and molecular lifetimes suggest that initial ablation of the metal doped carbon target results in atomic and small molecular species. The metal atoms survive for several milliseconds while the gaseous carbon atoms and small molecules nucleate more rapidly. Additional experiments and the development of in situ methods for carbon nanotube detection would allow these results to be interpreted from the perspective of carbon nanotube formation.

Proton channel models

PubMed Central

Pupo, Amaury; Baez-Nieto, David; Martínez, Agustín; Latorre, Ramón; González, Carlos

2014-01-01

Voltage-gated proton channels are integral membrane proteins with the capacity to permeate elementary particles in a voltage and pH dependent manner. These proteins have been found in several species and are involved in various physiological processes. Although their primary topology is known, lack of details regarding their structures in the open conformation has limited analyses toward a deeper understanding of the molecular determinants of their function and regulation. Consequently, the function-structure relationships have been inferred based on homology models. In the present work, we review the existing proton channel models, their assumptions, predictions and the experimental facts that support them. Modeling proton channels is not a trivial task due to the lack of a close homolog template. Hence, there are important differences between published models. This work attempts to critically review existing proton channel models toward the aim of contributing to a better understanding of the structural features of these proteins. PMID:24755912

Soccer science and the Bayes community: exploring the cognitive implications of modern scientific communication.

PubMed

Shrager, Jeff; Billman, Dorrit; Convertino, Gregorio; Massar, J P; Pirolli, Peter

2010-01-01

Science is a form of distributed analysis involving both individual work that produces new knowledge and collaborative work to exchange information with the larger community. There are many particular ways in which individual and community can interact in science, and it is difficult to assess how efficient these are, and what the best way might be to support them. This paper reports on a series of experiments in this area and a prototype implementation using a research platform called CACHE. CACHE both supports experimentation with different structures of interaction between individual and community cognition and serves as a prototype for computational support for those structures. We particularly focus on CACHE-BC, the Bayes community version of CACHE, within which the community can break up analytical tasks into "mind-sized" units and use provenance tracking to keep track of the relationship between these units. Copyright © 2009 Cognitive Science Society, Inc.

A keyword spotting model using perceptually significant energy features

NASA Astrophysics Data System (ADS)

Umakanthan, Padmalochini

The task of a keyword recognition system is to detect the presence of certain words in a conversation based on the linguistic information present in human speech. Such keyword spotting systems have applications in homeland security, telephone surveillance and human-computer interfacing. General procedure of a keyword spotting system involves feature generation and matching. In this work, new set of features that are based on the psycho-acoustic masking nature of human speech are proposed. After developing these features a time aligned pattern matching process was implemented to locate the words in a set of unknown words. A word boundary detection technique based on frame classification using the nonlinear characteristics of speech is also addressed in this work. Validation of this keyword spotting model was done using widely acclaimed Cepstral features. The experimental results indicate the viability of using these perceptually significant features as an augmented feature set in keyword spotting.

An automated microphysiological assay for toxicity evaluation.

PubMed

Eggert, S; Alexander, F A; Wiest, J

2015-08-01

Screening a newly developed drug, food additive or cosmetic ingredient for toxicity is a critical preliminary step before it can move forward in the development pipeline. Due to the sometimes dire consequences when a harmful agent is overlooked, toxicologists work under strict guidelines to effectively catalogue and classify new chemical agents. Conventional assays involve long experimental hours and many manual steps that increase the probability of user error; errors that can potentially manifest as inaccurate toxicology results. Automated assays can overcome many potential mistakes that arise due to human error. In the presented work, we created and validated a novel, automated platform for a microphysiological assay that can examine cellular attributes with sensors measuring changes in cellular metabolic rate, oxygen consumption, and vitality mediated by exposure to a potentially toxic agent. The system was validated with low buffer culture medium with varied conductivities that caused changes in the measured impedance on integrated impedance electrodes.

Microglia and neuroprotection: implications for Alzheimer's disease.

PubMed

Streit, Wolfgang J

2005-04-01

The first part of this paper summarizes some of the key observations from experimental work in animals that support a role of microglia as neuroprotective cells after acute neuronal injury. These studies point towards an important role of neuronal-microglial crosstalk in the facilitation of neuroprotection. Conceptually, injured neurons are thought to generate rescue signals that trigger microglial activation and, in turn, activated microglia produce trophic or other factors that help damaged neurons recover from injury. Against this background, the second part of this paper summarizes recent work from postmortem studies conducted in humans that have revealed the occurrence of senescent, or dystrophic, microglial cells in the aged and Alzheimer's disease brain. These findings suggest that microglial cells become increasingly dysfunctional with advancing age and that a loss of microglial cell function may involve a loss of neuroprotective properties that could contribute to the development of aging-related neurodegeneration.

Heinrich Hertz and Philipp Lenard: Two Distinguished Physicists, Two Disparate Men

NASA Astrophysics Data System (ADS)

Mulligan, Joseph F.

1999-12-01

Heinrich Hertz (1857-1894) and Philipp Lenard (1862-1947) both had distinguished careers as physicists. They were together in Bonn from April 1891 to January 1894, Hertz as Director of the Bonn Physics Institute, and Lenard as his assistant. Each did important experimental work on cathode rays and the photoelectric effect, and in 1905 Lenard received the Nobel Prize for his work in these fields. Lenard had great respect and admiration for Hertz before going to Bonn and while there, but gradually allowed his esteem for his mentor (who died in 1894) to diminish as Lenard became increasingly anti-Semitic and involved in National Socialism and the Nazi movement. This article illustrates how differences in their characters and personalities, together with the tragic events of the Great War and its aftermath, resulted in Hertz deservedly being much more highly regarded today both as a physicist and as a man than is Lenard.

Refractory materials for high-temperature thermoelectric energy conversion

NASA Technical Reports Server (NTRS)

Wood, C.; Emin, D.

1983-01-01

Theoretical work of two decades ago adequately explained the transport behavior and effectively guided the development of thermoelectric materials of high conversion efficiencies of conventional semiconductors (e.g., SiGe alloys). The more significant contributions involved the estimation of optimum doping concentrations, the reduction of thermal conductivity by solid solution doping and the development of a variety of materials with ZT approx. 1 in the temperature range 300 K to 1200 K. ZT approx. 1 is not a theoretical limitation although, experimentally, values in excess of one were not achieved. Work has continued with emphasis on higher temperature energy conversion. A number of promising materials have been discovered in which it appears that ZT 1 is realizable. These materials are divided into two classes: (1) the rare-earth chalcogenides which behave as itinerant highly-degenerate n-type semiconductors at room-temperature, and (2) the boron-rich borides, which exhibit p-type small-polaronic hopping conductivity.

Analysis and observation of moving domain fronts in a ring of coupled electronic self-oscillators

NASA Astrophysics Data System (ADS)

English, L. Q.; Zampetaki, A.; Kevrekidis, P. G.; Skowronski, K.; Fritz, C. B.; Abdoulkary, Saidou

2017-10-01

In this work, we consider a ring of coupled electronic (Wien-bridge) oscillators from a perspective combining modeling, simulation, and experimental observation. Following up on earlier work characterizing the pairwise interaction of Wien-bridge oscillators by Kuramoto-Sakaguchi phase dynamics, we develop a lattice model for a chain thereof, featuring an exponentially decaying spatial kernel. We find that for certain values of the Sakaguchi parameter α, states of traveling phase-domain fronts involving the coexistence of two clearly separated regions of distinct dynamical behavior, can establish themselves in the ring lattice. Experiments and simulations show that stationary coexistence domains of synchronization only manifest themselves with the introduction of a local impurity; here an incoherent cluster of oscillators can arise reminiscent of the chimera states in a range of systems with homogeneous oscillators and suitable nonlocal interactions between them.

Giving students the run of sprinting models

NASA Astrophysics Data System (ADS)

Heck, André; Ellermeijer, Ton

2009-11-01

A biomechanical study of sprinting is an interesting task for students who have a background in mechanics and calculus. These students can work with real data and do practical investigations similar to the way sports scientists do research. Student research activities are viable when the students are familiar with tools to collect and work with data from sensors and video recordings and with modeling tools for comparing simulation and experimental results. This article describes a multipurpose system, named COACH, that offers a versatile integrated set of tools for learning, doing, and teaching mathematics and science in a computer-based inquiry approach. Automated tracking of reference points and correction of perspective distortion in videos, state-of-the-art algorithms for data smoothing and numerical differentiation, and graphical system dynamics based modeling are some of the built-in techniques that are suitable for motion analysis. Their implementation and their application in student activities involving models of running are discussed.

A mechanistic investigation of the algae growth "Droop" model.

PubMed

Lemesle, V; Mailleret, L

2008-06-01

In this work a mechanistic explanation of the classical algae growth model built by M. R. Droop in the late sixties is proposed. We first recall the history of the construction of the "predictive" variable yield Droop model as well as the meaning of the introduced cell quota. We then introduce some theoretical hypotheses on the biological phenomena involved in nutrient storage by the algae that lead us to a "conceptual" model. Though more complex than Droop's one, our model remains accessible to a complete mathematical study: its confrontation to the Droop model shows both have the same asymptotic behavior. However, while Droop's cell quota comes from experimental bio-chemical measurements not related to intra-cellular biological phenomena, its analogous in our model directly follows our theoretical hypotheses. This new model should then be looked at as a re-interpretation of Droop's work from a theoretical biologist's point of view.

Automated payload and instruments for astrobiology research developed and studied by German medium-sized space industry in cooperation with European academia

NASA Astrophysics Data System (ADS)

Schulte, Wolfgang; Hofer, Stefan; Hofmann, Peter; Thiele, Hans; von Heise-Rotenburg, Ralf; Toporski, Jan; Rettberg, Petra

2007-06-01

For more than a decade Kayser-Threde, a medium-sized enterprise of the German space industry, has been involved in astrobiology research in partnership with a variety of scientific institutes from all over Europe. Previous projects include exobiology research platforms in low Earth orbit on retrievable carriers and onboard the Space Station. More recently, exobiology payloads for in situ experimentation on Mars have been studied by Kayser-Threde under ESA contracts, specifically the ExoMars Pasteur Payload. These studies included work on a sample preparation and distribution systems for Martian rock/regolith samples, instrument concepts such as Raman spectroscopy and a Life Marker Chip, advanced microscope systems as well as robotic tools for astrobiology missions. The status of the funded technical studies and major results are presented. The reported industrial work was funded by ESA and the German Aerospace Center (DLR).

Complex nonlinear dynamics in the limit of weak coupling of a system of microcantilevers connected by a geometrically nonlinear tunable nanomembrane.

PubMed

Jeong, Bongwon; Cho, Hanna; Keum, Hohyun; Kim, Seok; Michael McFarland, D; Bergman, Lawrence A; King, William P; Vakakis, Alexander F

2014-11-21

Intentional utilization of geometric nonlinearity in micro/nanomechanical resonators provides a breakthrough to overcome the narrow bandwidth limitation of linear dynamic systems. In past works, implementation of intentional geometric nonlinearity to an otherwise linear nano/micromechanical resonator has been successfully achieved by local modification of the system through nonlinear attachments of nanoscale size, such as nanotubes and nanowires. However, the conventional fabrication method involving manual integration of nanoscale components produced a low yield rate in these systems. In the present work, we employed a transfer-printing assembly technique to reliably integrate a silicon nanomembrane as a nonlinear coupling component onto a linear dynamic system with two discrete microcantilevers. The dynamics of the developed system was modeled analytically and investigated experimentally as the coupling strength was finely tuned via FIB post-processing. The transition from the linear to the nonlinear dynamic regime with gradual change in the coupling strength was experimentally studied. In addition, we observed for the weakly coupled system that oscillation was asynchronous in the vicinity of the resonance, thus exhibiting a nonlinear complex mode. We conjectured that the emergence of this nonlinear complex mode could be attributed to the nonlinear damping arising from the attached nanomembrane.

Design and development of experimental facilities for short duration, low-gravity combustion and fire experiments

NASA Technical Reports Server (NTRS)

Motevalli, Vahid

1994-01-01

This report contains the results of three projects conducted by undergraduate students from Worcester Polytechnic Institute at the NASA's Lewis Research Center under a NASA Award NCC3-312. The students involved in these projects spent part of the summer of 1993 at the Lewis Research Center (LeRC) under the direction of Dr. Howard Ross, head of the Combustion group and other NASA engineers and scientists. The Principal Investigator at Worcester Polytechnic Institute was Professor Vahid Motevalli. Professor Motevalli served as the principal project advisor for two of the three projects which were in Mechanical Engineering. The third project was advised by Professor Duckworth of Electrical and Computer Engineering, while Professor Motevalli acted as the co-advisor. These projects provided an excellent opportunity for the students to participate in the cutting edge research and engineering design, interact with NASA engineers and gain valuable exposure to a real working environment. Furthermore, the combustion group at LeRC was able to forward their goals by employing students to work on topics of immediate use and interest such as experimental research projects planned for the space shuttle, the future space station, or to develop demonstration tools to educate the public about LeRC activities.

Types of flow on the lee side of delta wings

NASA Astrophysics Data System (ADS)

Narayan, K. Yegna; Seshadri, S. N.

1997-03-01

Delta wings have found wide application in a variety of aerospace vehicles including high performance combat aircraft, supersonic civil aircraft, (proposed) hypersonic aircraft and the space shuttle orbiter. A considerable amount of research work has been carried out over the past three decades and an extensive body of literature is available. The present review focuses attention on the nine possible types of flow that can occur on the lee side of delta wings in a Mach number range which extends from subsonic to hypersonic. The dependence of the flow types on geometrical and freestream parameters has been discussed in detail. The extensive experimental data available has made it possible to obtain a broad physical understanding of the mechanisms underlying the different flow types. However much more work needs to be done to determine the effects of Reynolds number, particularly when either the state of the boundary layer is transitional or when the type of flow is changing from leading edge attached to separated. Computational methods have made spectacular advances in recent years. In particular, solutions of Reynolds averaged Navier-Stokes equations at fairly high Reynolds number have become possible and these computations have captured eight of the nine experimentally observed flow types, including those involving cross flow shock waves and shock-induced separation.

Effect of Crusher Type and Crusher Discharge Setting On Washability Characteristics of Coal

NASA Astrophysics Data System (ADS)

Ahila, P.; Battacharya, S.

2018-02-01

Natural resources have been serving the life of many civilizations, among these coals are of prime importance. Coal is the most important and abundant fossil fuel in India. It accounts for 55% of the country’s energy need. Coal will continue as the mainstay fuel for power generation. Previous researches has been made about the coal feed size and coal type had great influence on the crushing performance of the same jaw crusher and amount of fines generated from a particular coal depends not only upon coal friability but also on crusher type. Therefore, it necessitates crushing and grinding the coal for downstream process. In this paper the effect of crusher type and crusher discharge setting on washability characteristics of same crushed non-coking coal has been studied. Thus four different crushers were investigated at variable parameters like discharge settings, different capacities and feed openings. The experimental work conducted for all crushers with same feed size and HGI (Hardgrove Grindability Index). Based on the investigation the results indicate that the four crushers which has been involved for the experimental work shows that the variation in not only the product size distribution and also reduction ratio. Maximum breakage has been occurred at coarsest size fraction of irrespective of crusher type and discharge setting.

Development of Meteorological Towers Using Advanced Composite Materials

NASA Astrophysics Data System (ADS)

Alshurafa, Sami A.

The research program involved both numerical and experimental work. The numerical analysis was conducted to simulate the static and dynamic behaviour of the 81 m meteorological FRP guyed tower under wind and ice loading. The FRP tower consisted of 16 segments each made of 3 cells connected together to form an equilateral triangle having equal sides of 450 mm. The segments were interconnected using internal sleeves. Various non-linear finite element models were developed to study a number of design parameters for the 81 m FRP tower such as, different laminates containing a variety of stacking sequences of laminate orientations with various thicknesses, different cable diameters, and appropriate guy cable spacing levels. The effect of pre-stressing the guy cables up to 10 % of their breaking strength was investigated. The effect of fibre volume fraction on the design of the FRP tower was also examined. Furthermore, an 8.6 m FRP tower segment was designed using the finite element analysis and subject to the same loading conditions experienced by the bottom section of the 81 m FRP tower. A modal analysis was carried out for both the 8.6 m FRP tower segment with and without a mass on the top as well as for the 81 m FRP guyed tower to evaluate the vibration performance of these towers. The experimental work involved extensive material testing to define the material properties for use in the analysis of the 81 m FRP tower. It also involved the design and fabrication of a special collapsible mandrel for fabricating the FRP cells for the 8.6 m tower segment. The 8.6 m tower was tested horizontally under static lateral loading to 80 % of its estimated failure load using a "whiffle tree" arrangement, in order to simulate a uniformly distributed wind loading. Later, the same FRP tower was erected in a vertical position and was tested with and without a mass on top under dynamic loading to obtain the natural frequencies. Lastly, a comparative study was conducted between two 81 m FRP towers having different fibre volume fractions and a steel tower having a circular cross section.

Measuring saliency in images: which experimental parameters for the assessment of image quality?

NASA Astrophysics Data System (ADS)

Fredembach, Clement; Woolfe, Geoff; Wang, Jue

2012-01-01

Predicting which areas of an image are perceptually salient or attended to has become an essential pre-requisite of many computer vision applications. Because observers are notoriously unreliable in remembering where they look a posteriori, and because asking where they look while observing the image necessarily in uences the results, ground truth about saliency and visual attention has to be obtained by gaze tracking methods. From the early work of Buswell and Yarbus to the most recent forays in computer vision there has been, perhaps unfortunately, little agreement on standardisation of eye tracking protocols for measuring visual attention. As the number of parameters involved in experimental methodology can be large, their individual in uence on the nal results is not well understood. Consequently, the performance of saliency algorithms, when assessed by correlation techniques, varies greatly across the literature. In this paper, we concern ourselves with the problem of image quality. Specically: where people look when judging images. We show that in this case, the performance gap between existing saliency prediction algorithms and experimental results is signicantly larger than otherwise reported. To understand this discrepancy, we rst devise an experimental protocol that is adapted to the task of measuring image quality. In a second step, we compare our experimental parameters with the ones of existing methods and show that a lot of the variability can directly be ascribed to these dierences in experimental methodology and choice of variables. In particular, the choice of a task, e.g., judging image quality vs. free viewing, has a great impact on measured saliency maps, suggesting that even for a mildly cognitive task, ground truth obtained by free viewing does not adapt well. Careful analysis of the prior art also reveals that systematic bias can occur depending on instrumental calibration and the choice of test images. We conclude this work by proposing a set of parameters, tasks and images that can be used to compare the various saliency prediction methods in a manner that is meaningful for image quality assessment.

Effect of an office worksite-based yoga program on heart rate variability: outcomes of a randomized controlled trial

PubMed Central

2013-01-01

Background Chronic work-related stress is an independent risk factor for cardiometabolic diseases and associated mortality, particularly when compounded by a sedentary work environment. The purpose of this study was to determine if an office worksite-based hatha yoga program could improve physiological stress, evaluated via heart rate variability (HRV), and associated health-related outcomes in a cohort of office workers. Methods Thirty-seven adults employed in university-based office positions were randomized upon the completion of baseline testing to an experimental or control group. The experimental group completed a 10-week yoga program prescribed three sessions per week during lunch hour (50 min per session). An experienced instructor led the sessions, which emphasized asanas (postures) and vinyasa (exercises). The primary outcome was the high frequency (HF) power component of HRV. Secondary outcomes included additional HRV parameters, musculoskeletal fitness (i.e. push-up, side-bridge, and sit & reach tests) and psychological indices (i.e. state and trait anxiety, quality of life and job satisfaction). Results All measures of HRV failed to change in the experimental group versus the control group, except that the experimental group significantly increased LF:HF (p = 0.04) and reduced pNN50 (p = 0.04) versus control, contrary to our hypotheses. Flexibility, evaluated via sit & reach test increased in the experimental group versus the control group (p < 0.001). No other adaptations were noted. Post hoc analysis comparing participants who completed ≥70% of yoga sessions (n = 11) to control (n = 19) yielded the same findings, except that the high adherers also reduced state anxiety (p = 0.02) and RMSSD (p = 0.05), and tended to improve the push-up test (p = 0.07) versus control. Conclusions A 10-week hatha yoga intervention delivered at the office worksite during lunch hour did not improve HF power or other HRV parameters. However, improvements in flexibility, state anxiety and musculoskeletal fitness were noted with high adherence. Future investigations should incorporate strategies to promote adherence, involve more frequent and longer durations of yoga training, and enrol cohorts who suffer from higher levels of work-related stress. Trial registration ACTRN12611000536965 PMID:23574691

AN EXPERIMENTAL STUDY OF THE RELATIONSHIP OF FILM MOVEMENT AND EMOTIONAL RESPONSE, AND ITS EFFECT ON LEARNING AND ATTITUDE FORMATION.

ERIC Educational Resources Information Center

MILLER, WILLIAM CHARLES, III

THIS EXPERIMENTAL STUDY EXAMINED THE HYPOTHESES THAT FILM MOTION INCREASES AUDIENCE EMOTIONAL INVOLVEMENT, INCREASES POSITIVE ATTITUDE RESPONSE TO THE FILM AND DOES NOT AFFECT AUDIENCE INFORMATION RETENTION. OTHER HYPOTHESES WERE THAT THE GALVANIC SKIN RESPONSE (GSR) IS USEFUL FOR EVALUATING FILM AUDIENCE EMOTIONAL INVOLVEMENT, THAT AUDIENCE…

Auditory-motor interaction revealed by fMRI: speech, music, and working memory in area Spt.

PubMed

Hickok, Gregory; Buchsbaum, Bradley; Humphries, Colin; Muftuler, Tugan

2003-07-01

The concept of auditory-motor interaction pervades speech science research, yet the cortical systems supporting this interface have not been elucidated. Drawing on experimental designs used in recent work in sensory-motor integration in the cortical visual system, we used fMRI in an effort to identify human auditory regions with both sensory and motor response properties, analogous to single-unit responses in known visuomotor integration areas. The sensory phase of the task involved listening to speech (nonsense sentences) or music (novel piano melodies); the "motor" phase of the task involved covert rehearsal/humming of the auditory stimuli. A small set of areas in the superior temporal and temporal-parietal cortex responded both during the listening phase and the rehearsal/humming phase. A left lateralized region in the posterior Sylvian fissure at the parietal-temporal boundary, area Spt, showed particularly robust responses to both phases of the task. Frontal areas also showed combined auditory + rehearsal responsivity consistent with the claim that the posterior activations are part of a larger auditory-motor integration circuit. We hypothesize that this circuit plays an important role in speech development as part of the network that enables acoustic-phonetic input to guide the acquisition of language-specific articulatory-phonetic gestures; this circuit may play a role in analogous musical abilities. In the adult, this system continues to support aspects of speech production, and, we suggest, supports verbal working memory.

Using interprofessional simulation to improve collaborative competences for nursing, physiotherapy, and respiratory therapy students.

PubMed

King, Judy; Beanlands, Sarah; Fiset, Valerie; Chartrand, Louise; Clarke, Shelley; Findlay, Tarra; Morley, Michelle; Summers, Ian

2016-09-01

Within the care of people living with respiratory conditions, nursing, physiotherapy, and respiratory therapy healthcare professionals routinely work in interprofessional teams. To help students prepare for their future professional roles, there is a need for them to be involved in interprofessional education. The purpose of this project was to compare two different methods of patient simulation in improving interprofessional competencies for students in nursing, physiotherapy, and respiratory therapy programmes. The Canadian Interprofessional Health Collaborative competencies of communication, collaboration, conflict resolution patient/family-centred care, roles and responsibilities, and team functioning were measured. Using a quasi-experimental pre-post intervention approach two different interprofessional workshops were compared: the combination of standardised and simulated patients, and exclusively standardised patients. Students from nursing, physiotherapy, and respiratory therapy programmes worked together in these simulation-based activities to plan and implement care for a patient with a respiratory condition. Key results were that participants in both years improved in their self-reported interprofessional competencies as measured by the Interprofessional Collaborative Competencies Attainment Survey (ICCAS). Participants indicated that they found their interprofessional teams did well with communication and collaboration. But the participants felt they could have better involved the patients and their family members in the patient's care. Regardless of method of patient simulation used, mannequin or standardised patients, students found the experience beneficial and appreciated the opportunity to better understand the roles of other healthcare professionals in working together to help patients living with respiratory conditions.

Enhanced biocatalytic esterification with lipase-immobilized chitosan/graphene oxide beads.

PubMed

Lau, Siaw Cheng; Lim, Hong Ngee; Basri, Mahiran; Fard Masoumi, Hamid Reza; Ahmad Tajudin, Asilah; Huang, Nay Ming; Pandikumar, Alagarsamy; Chia, Chin Hua; Chia, Chi Hua; Andou, Yoshito

2014-01-01

In this work, lipase from Candida rugosa was immobilized onto chitosan/graphene oxide beads. This was to provide an enzyme-immobilizing carrier with excellent enzyme immobilization activity for an enzyme group requiring hydrophilicity on the immobilizing carrier. In addition, this work involved a process for the preparation of an enzymatically active product insoluble in a reaction medium consisting of lauric acid and oleyl alcohol as reactants and hexane as a solvent. This product enabled the stability of the enzyme under the working conditions and allowed the enzyme to be readily isolated from the support. In particular, this meant that an enzymatic reaction could be stopped by the simple mechanical separation of the "insoluble" enzyme from the reaction medium. Chitosan was incorporated with graphene oxide because the latter was able to enhance the physical strength of the chitosan beads by its superior mechanical integrity and low thermal conductivity. The X-ray diffraction pattern showed that the graphene oxide was successfully embedded within the structure of the chitosan. Further, the lipase incorporation on the beads was confirmed by a thermo-gravimetric analysis. The lipase immobilization on the beads involved the functionalization with coupling agents, N-hydroxysulfosuccinimide sodium (NHS) and 1-ethyl-(3-dimethylaminopropyl) carbodiimide (EDC), and it possessed a high enzyme activity of 64 U. The overall esterification conversion of the prepared product was 78% at 60 °C, and it attained conversions of 98% and 88% with commercially available lipozyme and novozyme, respectively, under similar experimental conditions.

Enhanced Biocatalytic Esterification with Lipase-Immobilized Chitosan/Graphene Oxide Beads

PubMed Central

Lau, Siaw Cheng; Lim, Hong Ngee; Basri, Mahiran; Fard Masoumi, Hamid Reza; Ahmad Tajudin, Asilah; Huang, Nay Ming; Pandikumar, Alagarsamy; Chia, Chi Hua; Andou, Yoshito

2014-01-01

In this work, lipase from Candida rugosa was immobilized onto chitosan/graphene oxide beads. This was to provide an enzyme-immobilizing carrier with excellent enzyme immobilization activity for an enzyme group requiring hydrophilicity on the immobilizing carrier. In addition, this work involved a process for the preparation of an enzymatically active product insoluble in a reaction medium consisting of lauric acid and oleyl alcohol as reactants and hexane as a solvent. This product enabled the stability of the enzyme under the working conditions and allowed the enzyme to be readily isolated from the support. In particular, this meant that an enzymatic reaction could be stopped by the simple mechanical separation of the “insoluble” enzyme from the reaction medium. Chitosan was incorporated with graphene oxide because the latter was able to enhance the physical strength of the chitosan beads by its superior mechanical integrity and low thermal conductivity. The X-ray diffraction pattern showed that the graphene oxide was successfully embedded within the structure of the chitosan. Further, the lipase incorporation on the beads was confirmed by a thermo-gravimetric analysis. The lipase immobilization on the beads involved the functionalization with coupling agents, N-hydroxysulfosuccinimide sodium (NHS) and 1-ethyl-(3-dimethylaminopropyl) carbodiimide (EDC), and it possessed a high enzyme activity of 64 U. The overall esterification conversion of the prepared product was 78% at 60°C, and it attained conversions of 98% and 88% with commercially available lipozyme and novozyme, respectively, under similar experimental conditions. PMID:25127038

Laser-Assisted Bending of Sharp Angles With Small Fillet Radius on Stainless Steel Sheets: Analysis of Experimental Set-Up and Processing Parameters

NASA Astrophysics Data System (ADS)

Gisario, Annamaria; Barletta, Massimiliano; Venettacci, Simone; Veniali, Francesco

2015-06-01

Achievement of sharp bending angles with small fillet radius on stainless steel sheets by mechanical bending requires sophisticated bending device and troublesome operational procedures, which can involve expensive molds, huge presses and large loads. In addition, springback is always difficult to control, thus often leading to final parts with limited precision and accuracy. In contrast, laser-assisted bending of metals is an emerging technology, as it often allows to perform difficult and multifaceted manufacturing tasks with relatively small efforts. In the present work, laser-assisted bending of stainless steel sheets to achieve sharp angles is thus investigated. First, bending trials were performed by combining laser irradiation with an auxiliary bending device triggered by a pneumatic actuator and based on kinematic of deformable quadrilaterals. Second, laser operational parameters, that is, scanning speed, power and number of passes, were varied to identify the most suitable processing settings. Bending angles and fillet radii were measured by coordinate measurement machine. Experimental data were elaborated by combined ANalysis Of Mean (ANOM) and ANalysis Of VAriance (ANOVA). Based on experimental findings, the best strategy to achieve an aircraft prototype from a stainless steel sheet was designed and implemented.

Development of quantitative radioactive methodologies on paper to determine important lateral-flow immunoassay parameters.

PubMed

Mosley, Garrett L; Nguyen, Phuong; Wu, Benjamin M; Kamei, Daniel T

2016-08-07

The lateral-flow immunoassay (LFA) is a well-established diagnostic technology that has recently seen significant advancements due in part to the rapidly expanding fields of paper diagnostics and paper-fluidics. As LFA-based diagnostics become more complex, it becomes increasingly important to quantitatively determine important parameters during the design and evaluation process. However, current experimental methods for determining these parameters have certain limitations when applied to LFA systems. In this work, we describe our novel methods of combining paper and radioactive measurements to determine nanoprobe molarity, the number of antibodies per nanoprobe, and the forward and reverse rate constants for nanoprobe binding to immobilized target on the LFA test line. Using a model LFA system that detects for the presence of the protein transferrin (Tf), we demonstrate the application of our methods, which involve quantitative experimentation and mathematical modeling. We also compare the results of our rate constant experiments with traditional experiments to demonstrate how our methods more appropriately capture the influence of the LFA environment on the binding interaction. Our novel experimental approaches can therefore more efficiently guide the research process for LFA design, leading to more rapid advancement of the field of paper-based diagnostics.

Controlling chaotic behavior in CO2 and other lasers

NASA Astrophysics Data System (ADS)

1993-06-01

Additional substantial experimental progress has been made, in the third month of the project, in setting up equipment and testing for producing chaotic behavior with a CO2 laser. The project goal is to synchronize and control chaos in CO2 and other lasers, and thereby increase the power in ensembles of coupled laser sources. Numerous investigations into the chaos regime have been made, a second CO2 laser has been brought on stream, and work is progressing in the fourth month toward coupling the two lasers and control of the first laser. It is also intended to submit at least two papers to the Second Experimental Chaos Conference which is supported by the Office of Naval Research. Abstracts to those two papers are attached. Last month's report discussed the experimental investigation of nonlinear dynamics of CO2 lasers which involved a new technique of inducing chaos. In this new technique, an acoustically modulated feedback of the laser light was used and led to chaotic dynamics at a very low modulation frequency of 375 Hz. Since then, new results have been obtained by an Electro-Optical Modulation (EOM) technique. In the new setup, the electro-optical modulator is placed in an external cavity outside the laser.

1D quantum simulation using a solid state platform

NASA Astrophysics Data System (ADS)

Kirkendall, Megan; Irvin, Patrick; Huang, Mengchen; Levy, Jeremy; Lee, Hyungwoo; Eom, Chang-Beom

Understanding the properties of large quantum systems can be challenging both theoretically and numerically. One experimental approach-quantum simulation-involves mapping a quantum system of interest onto a physical system that is programmable and experimentally accessible. A tremendous amount of work has been performed with quantum simulators formed from optical lattices; by contrast, solid-state platforms have had only limited success. Our experimental approach to quantum simulation takes advantage of nanoscale control of a metal-insulator transition at the interface between two insulating complex oxide materials. This system naturally exhibits a wide variety of ground states (e.g., ferromagnetic, superconducting) and can be configured into a variety of complex geometries. We will describe initial experiments that explore the magnetotransport properties of one-dimensional superlattices with spatial periods as small as 4 nm, comparable to the Fermi wavelength. The results demonstrate the potential of this solid-state quantum simulation approach, and also provide empirical constraints for physical models that describe the underlying oxide material properties. We gratefully acknowledge financial support from AFOSR (FA9550-12-1- 0057 (JL), FA9550-10-1-0524 (JL) and FA9550-12-1-0342 (CBE)), ONR N00014-15-1-2847 (JL), and NSF DMR-1234096 (CBE).

Analytical and experimental study of the acoustics and the flow field characteristics of cavitating self-resonating water jets

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chahine, G.L.; Genoux, P.F.; Johnson, V.E. Jr.

1984-09-01

Waterjet nozzles (STRATOJETS) have been developed which achieve passive structuring of cavitating submerged jets into discrete ring vortices, and which possess cavitation incipient numbers six times higher than obtained with conventional cavitating jet nozzles. In this study we developed analytical and numerical techniques and conducted experimental work to gain an understanding of the basic phenomena involved. The achievements are: (1) a thorough analysis of the acoustic dynamics of the feed pipe to the nozzle; (2) a theory for bubble ring growth and collapse; (3) a numerical model for jet simulation; (4) an experimental observation and analysis of candidate second-generation low-sigmamore » STRATOJETS. From this study we can conclude that intensification of bubble ring collapse and design of highly resonant feed tubes can lead to improved drilling rates. The models here described are excellent tools to analyze the various parameters needed for STRATOJET optimizations. Further analysis is needed to introduce such important factors as viscosity, nozzle-jet interaction, and ring-target interaction, and to develop the jet simulation model to describe the important fine details of the flow field at the nozzle exit.« less

Experimental characterization and modelization of ion exchange kinetics for a carboxylic resin in infinite solution volume conditions. Application to monovalent-trivalent cations exchange.

PubMed

Picart, Sébastien; Ramière, Isabelle; Mokhtari, Hamid; Jobelin, Isabelle

2010-09-02

This study is devoted to the characterization of ion exchange inside a microsphere of carboxylic resin. It aims at describing the kinetics of this exchange reaction which is known to be controlled by interdiffusion in the particle. The fractional attainment of equilibrium function of time depends on the concentration of the cations in the resin which can be modelized by the Nernst-Planck equation. A powerful approach for the numerical resolution of this equation is introduced in this paper. This modeling is based on the work of Helfferich but involves an implicit numerical scheme which reduces the computational cost. Knowing the diffusion coefficients of the cations in the resin and the radius of the spherical exchanger, the kinetics can be hence completely determined. When those diffusion parameters are missing, they can be deduced by fitting experimental data of fractional attainment of equilibrium. An efficient optimization tool coupled with the implicit resolution has been developed for this purpose. A monovalent/trivalent cation exchange had been experimentally characterized for a carboxylic resin. Diffusion coefficients and concentration profiles in the resin were then deduced through this new model.

Plasticity of attentional functions in older adults after non-action video game training: a randomized controlled trial.

PubMed

Mayas, Julia; Parmentier, Fabrice B R; Andrés, Pilar; Ballesteros, Soledad

2014-01-01

A major goal of recent research in aging has been to examine cognitive plasticity in older adults and its capacity to counteract cognitive decline. The aim of the present study was to investigate whether older adults could benefit from brain training with video games in a cross-modal oddball task designed to assess distraction and alertness. Twenty-seven healthy older adults participated in the study (15 in the experimental group, 12 in the control group. The experimental group received 20 1-hr video game training sessions using a commercially available brain-training package (Lumosity) involving problem solving, mental calculation, working memory and attention tasks. The control group did not practice this package and, instead, attended meetings with the other members of the study several times along the course of the study. Both groups were evaluated before and after the intervention using a cross-modal oddball task measuring alertness and distraction. The results showed a significant reduction of distraction and an increase of alertness in the experimental group and no variation in the control group. These results suggest neurocognitive plasticity in the old human brain as training enhanced cognitive performance on attentional functions. ClinicalTrials.gov NCT02007616.

Active Flow Control: Instrumentation Automation and Experimental Technique

NASA Technical Reports Server (NTRS)

Gimbert, N. Wes

1995-01-01

In investigating the potential of a new actuator for use in an active flow control system, several objectives had to be accomplished, the largest of which was the experimental setup. The work was conducted at the NASA Langley 20x28 Shear Flow Control Tunnel. The actuator named Thunder, is a high deflection piezo device recently developed at Langley Research Center. This research involved setting up the instrumentation, the lighting, the smoke, and the recording devices. The instrumentation was automated by means of a Power Macintosh running LabVIEW, a graphical instrumentation package developed by National Instruments. Routines were written to allow the tunnel conditions to be determined at a given instant at the push of a button. This included determination of tunnel pressures, speed, density, temperature, and viscosity. Other aspects of the experimental equipment included the set up of a CCD video camera with a video frame grabber, monitor, and VCR to capture the motion. A strobe light was used to highlight the smoke that was used to visualize the flow. Additional effort was put into creating a scale drawing of another tunnel on site and a limited literature search in the area of active flow control.

A metadata approach for clinical data management in translational genomics studies in breast cancer.

PubMed

Papatheodorou, Irene; Crichton, Charles; Morris, Lorna; Maccallum, Peter; Davies, Jim; Brenton, James D; Caldas, Carlos

2009-11-30

In molecular profiling studies of cancer patients, experimental and clinical data are combined in order to understand the clinical heterogeneity of the disease: clinical information for each subject needs to be linked to tumour samples, macromolecules extracted, and experimental results. This may involve the integration of clinical data sets from several different sources: these data sets may employ different data definitions and some may be incomplete. In this work we employ semantic web techniques developed within the CancerGrid project, in particular the use of metadata elements and logic-based inference to annotate heterogeneous clinical information, integrate and query it. We show how this integration can be achieved automatically, following the declaration of appropriate metadata elements for each clinical data set; we demonstrate the practicality of this approach through application to experimental results and clinical data from five hospitals in the UK and Canada, undertaken as part of the METABRIC project (Molecular Taxonomy of Breast Cancer International Consortium). We describe a metadata approach for managing similarities and differences in clinical datasets in a standardized way that uses Common Data Elements (CDEs). We apply and evaluate the approach by integrating the five different clinical datasets of METABRIC.

Is Working Memory Involved in the Transcribing and Editing of Texts?

ERIC Educational Resources Information Center

Hayes, John R.; Chenoweth, N. Ann

2006-01-01

Generally, researchers agree that verbal working memory plays an important role in cognitive processes involved in writing. However, there is disagreement about which cognitive processes make use of working memory. Kellogg has proposed that verbal working memory is involved in translating but not in editing or producing (i.e., typing) text. In…

Involvement of Working Memory in Mental Multiplication in Chinese Elementary Students

ERIC Educational Resources Information Center

Liu, Ru-De; Ding, Yi; Xu, Le; Wang, Jia

2017-01-01

The authors' aim was to examine the relation between two-digit mental multiplication and working memory. In Study 1, involving 30 fifth-grade students, we used digit span backward as an abbreviated measure of working memory. In Study 2, involving 41 fourth-grade students, working memory comprised measures of phonological loop, visuospatial…

Introduction to the internal fluid mechanics research session

NASA Technical Reports Server (NTRS)

Miller, Brent A.; Povinelli, Louis A.

1990-01-01

Internal fluid mechanics research at LeRC is directed toward an improved understanding of the important flow physics affecting aerospace propulsion systems, and applying this improved understanding to formulate accurate predictive codes. To this end, research is conducted involving detailed experimentation and analysis. The following three papers summarize ongoing work and indicate future emphasis in three major research thrusts: inlets, ducts, and nozzles; turbomachinery; and chemical reacting flows. The underlying goal of the research in each of these areas is to bring internal computational fluid mechanic to a state of practical application for aerospace propulsion systems. Achievement of this goal requires that carefully planned and executed experiments be conducted in order to develop and validate useful codes. It is critical that numerical code development work and experimental work be closely coupled. The insights gained are represented by mathematical models that form the basis for code development. The resultant codes are then tested by comparing them with appropriate experiments in order to ensure their validity and determine their applicable range. The ultimate user community must be a part of this process to assure relevancy of the work and to hasten its practical application. Propulsion systems are characterized by highly complex and dynamic internal flows. Many complex, 3-D flow phenomena may be present, including unsteadiness, shocks, and chemical reactions. By focusing on specific portions of a propulsion system, it is often possible to identify the dominant phenomena that must be understood and modeled for obtaining accurate predictive capability. The three major research thrusts serve as a focus leading to greater understanding of the relevant physics and to an improvement in analytic tools. This in turn will hasten continued advancements in propulsion system performance and capability.

Using Numerical Modeling to Simulate Space Capsule Ground Landings

NASA Technical Reports Server (NTRS)

Heymsfield, Ernie; Fasanella, Edwin L.

2009-01-01

Experimental work is being conducted at the National Aeronautics and Space Administration s (NASA) Langley Research Center (LaRC) to investigate ground landing capabilities of the Orion crew exploration vehicle (CEV). The Orion capsule is NASA s replacement for the Space Shuttle. The Orion capsule will service the International Space Station and be used for future space missions to the Moon and to Mars. To evaluate the feasibility of Orion ground landings, a series of capsule impact tests are being performed at the NASA Langley Landing and Impact Research Facility (LandIR). The experimental results derived at LandIR provide means to validate and calibrate nonlinear dynamic finite element models, which are also being developed during this study. Because of the high cost and time involvement intrinsic to full-scale testing, numerical simulations are favored over experimental work. Subsequent to a numerical model validated by actual test responses, impact simulations will be conducted to study multiple impact scenarios not practical to test. Twenty-one swing tests using the LandIR gantry were conducted during the June 07 through October 07 time period to evaluate the Orion s impact response. Results for two capsule initial pitch angles, 0deg and -15deg , along with their computer simulations using LS-DYNA are presented in this article. A soil-vehicle friction coefficient of 0.45 was determined by comparing the test stopping distance with computer simulations. In addition, soil modeling accuracy is presented by comparing vertical penetrometer impact tests with computer simulations for the soil model used during the swing tests.

Comparative theoretical and experimental study of a Shack-Hartmann and a phase diversity sensor, for high-precision wavefront sensing dedicated to space active optics

NASA Astrophysics Data System (ADS)

Montmerle Bonnefois, A.; Fusco, T.; Meimon, S.; Michau, V.; Mugnier, L.; Sauvage, J.-F.; Engel, C.; Escolle, C.; Ferrari, M.; Hugot, E.; Liotard, A.; Bernot, M.; Carlavan, M.; Falzon, F.; Bret-Dibat, T.; Laubier, D.

2017-11-01

Earth-imaging or Universe Science satellites are always in need of higher spatial resolutions, in order to discern finer and finer details in images. This means that every new generation of satellites must have a larger main mirror than the previous one, because of the diffraction. Since it allows the use of larger mirrors, active optics is presently studied for the next generation of satellites. To measure the aberrations of such an active telescope, the Shack-Hartmann (SH), and the phase-diversity (PD) are the two wavefront sensors (WFS) considered preferentially because they are able to work with an extended source like the Earth's surface, as well as point sources like stars. The RASCASSE project was commissioned by the French spatial agency (CNES) to study the SH and PD sensors for high-performance wavefront sensing. It involved ONERA and Thales Alenia Space (TAS), and LAM. Papers by TAS and LAM on the same project are available in this conference, too [1,2]. The purpose of our work at ONERA was to explore what the best performance both wavefront sensors can achieve in a space optics context. So we first performed a theoretical study in order to identify the main sources of errors and quantify them - then we validated those results experimentally. The outline of this paper follows this approach: we first discuss phase diversity theoretical results, then Shack-Hartmann's, then experimental results - to finally conclude on each sensor's performance, and compare their weak and strong points.

Taking two to tango: fMRI analysis of improvised joint action with physical contact

PubMed Central

Belyk, Michel; Brown, Steven

2018-01-01

Many forms of joint action involve physical coupling between the participants, such as when moving a sofa together or dancing a tango. We report the results of a novel two-person functional MRI study in which trained couple dancers engaged in bimanual contact with an experimenter standing next to the bore of the magnet, and in which the two alternated between being the leader and the follower of joint improvised movements. Leading showed a general pattern of self-orientation, being associated with brain areas involved in motor planning, navigation, sequencing, action monitoring, and error correction. In contrast, following showed a far more sensory, externally-oriented pattern, revealing areas involved in somatosensation, proprioception, motion tracking, social cognition, and outcome monitoring. We also had participants perform a “mutual” condition in which the movement patterns were pre-learned and the roles were symmetric, thereby minimizing any tendency toward either leading or following. The mutual condition showed greater activity in brain areas involved in mentalizing and social reward than did leading or following. Finally, the analysis of improvisation revealed the dual importance of motor-planning and working-memory areas. We discuss these results in terms of theories of both joint action and improvisation. PMID:29324862

Is parents' work involvement responsive to the quality of relationships with adolescent offspring?

PubMed

Fortner, Melissa R; Crouter, Ann C; McHale, Susan M

2004-09-01

Researchers know relatively little about how family relationships influence work involvement, although individuals are concerned about how family life interferes with or enhances work experiences. This study examined change in parents' work involvement as a function of relationship quality with offspring (mean age = 15 years) with data from 191 families participating in a longitudinal study. Results suggested a compensatory association between parents' feelings of acceptance and warmth toward offspring and work involvement. Less positive acceptance predicted (a) increasing emotional job involvement for mothers with sons and fathers with daughters and (b) increasing work hours for fathers with daughters. Results highlight how parents may compensate for less positive relationships with adolescents and are discussed in terms of research and applied implications. Copyright 2004 American Psychological Association

Prediction of thinning of the sheet metal in the program AutoForm and its experimental verification

NASA Astrophysics Data System (ADS)

Fedorko, M.; Urbánek, M.; Rund, M.

2017-02-01

The manufacture of press-formed parts often involves deep-drawing operations. Deep drawing, however, can be deemed an industrial branch in its own right. Today, many experimental as well as numerical methods are available for designing and optimizing deep drawing operations. The best option, however, is to combine both approaches. The present paper describes one such investigation. Here, measurements and numerical simulation were used for mapping the impact of anisotropy on thickness variation in a spherical-shaped drawn part of DC01 steel. Variation in sheet thickness was measured on spherical-shaped drawn parts of various geometries by means of two cameras, and evaluated with digital image correlation using the ARAMIS software from the company GOM. The forming experiment was carried out on an INOVA 200 kN servohydraulic testing machine in which the force vs. piston displacement curve was recorded. The same experiment was then numerically simulated and analyzed using the AUTOFORM software. Various parameters were monitored, such as thinning, strain magnitude, formability, and others. For the purpose of this simulation, a series of mechanical tests was conducted to obtain descriptions of the experimental material of 1.5 mm thickness. A material model was constructed from the tests data involving the work-hardening curve, the impact of anisotropy, and the forming limit diagram. Specifically, these tests included tensile tests, the Nakajima test, and the stacked test, which were carried out to determine materials data for the model. The actual sheet thickness was measured on a sectioned spherical-shaped drawn part using a NIKON optical microscope. The variations in thickness along defined lines on the sectioned drawn part were compared with the numerical simulations data using digital image correlation. The above-described experimental programme is suitable for calibrating a material model for any computational software and can correctly solve deep-drawing problems.

The Use Of High Speed Photography In Reactor Safety Studies At The Atomic Energy Establishment, Winfrith

NASA Astrophysics Data System (ADS)

Maddison, R. J.

1985-02-01

The investigation of certain areas of nuclear reactor safety involves the study of high speed phenomena with timescales ranging from microseconds to a few hundreds of milliseconds. Examples which have been extensively studied at Winfrith are firstly, the thermal interaction of molten fuel and reactor coolant which can generate high pressures on the 100 msec timescale, and which involves phenomena such as vapour film collapse which takes place on the microsecond timescale. Secondly, there is the response of reactor structures to such pressures, and finally there is the response of structural materials such as metals and concrete to the impulsive loading arising from the impact of heavy, high velocity missiles. A wide range of experimental techniques is used in these studies, many of which have been developed specially for this type of work which ranges from small laboratory scale to large field scale experiments. There are two important features which characterise many of these experiments:- i) a long period of meticulous preparation of very heavily instrumented, short duration experiments and; ii) the destructive nature of the experiments. Various forms of High Speed photography are included in the inventory of experimental techniques. These include the use of single and double exposure, short duration, spark photography; the use of an Image Convertor Camera (IMACON 790); and a number of rotating prism cine cameras. High Speed Photography is used both in a primary experimental role in the studies, and in a supportive role for other instrumentation. Because of the sometimes violent nature of these experiments, cameras are often heavily protected and operated remotely; lighting systems are sometimes destroyed. This has led to the development of unconventional techniques for camera operation and subject lighting. This paper will describe some of the experiments and the way in which High Speed Photography has been applied as an essential experimental tool. It will be illustrated with cine film taken during the experiments.

In silico prediction of protein-protein interactions in human macrophages

PubMed Central

2014-01-01

Background Protein-protein interaction (PPI) network analyses are highly valuable in deciphering and understanding the intricate organisation of cellular functions. Nevertheless, the majority of available protein-protein interaction networks are context-less, i.e. without any reference to the spatial, temporal or physiological conditions in which the interactions may occur. In this work, we are proposing a protocol to infer the most likely protein-protein interaction (PPI) network in human macrophages. Results We integrated the PPI dataset from the Agile Protein Interaction DataAnalyzer (APID) with different meta-data to infer a contextualized macrophage-specific interactome using a combination of statistical methods. The obtained interactome is enriched in experimentally verified interactions and in proteins involved in macrophage-related biological processes (i.e. immune response activation, regulation of apoptosis). As a case study, we used the contextualized interactome to highlight the cellular processes induced upon Mycobacterium tuberculosis infection. Conclusion Our work confirms that contextualizing interactomes improves the biological significance of bioinformatic analyses. More specifically, studying such inferred network rather than focusing at the gene expression level only, is informative on the processes involved in the host response. Indeed, important immune features such as apoptosis are solely highlighted when the spotlight is on the protein interaction level. PMID:24636261

Effects of Using Tricaine Methanesulfonate and Metomidate before Euthanasia on the Contractile Properties of Rainbow Trout (Oncorhynchus mykiss) Myocardium.

PubMed

Roberts, Jordan C; Syme, Douglas A

2016-01-01

Because many anesthetics work through depressing cell excitability, unanesthetized euthanasia has become common for research involving excitable tissues (for example muscle and nerve) to avoid these depressive effects. However, anesthetic use during euthanasia may be indicated for studies involving isolated tissues if the potential depressive effects of brief anesthetic exposure dissipate after subsequent tissue isolation, washout, and saline perfusion. We explore this here by measuring whether, when applied prior to euthanasia, standard immersion doses of 2 fish anesthetics, tricaine methanesulfonate (TMS; 100 mg/L, n = 6) and methyl 1-(1-phenylethyl)-1H-imidazole-5-carboxylate (metomidate, 10 mg/L, n = 6), have residual effects on the contractile properties (force and work output) of isolated and saline-perfused ventricular compact myocardium from rainbow trout (Oncorhynchus mykiss). Results suggest that direct exposure of muscle to immersion doses of TMS-but not metomidate-impairs muscle contractile performance. However, brief exposure (2 to 3 min) to either anesthetic during euthanasia only-providing that the agent is washed out prior to tissue experimentation-does not have an effect on the contractile properties of the myocardium. Therefore, the use of TMS, metomidate, and perhaps other anesthetics that depress cell excitability during euthanasia may be indicated when conducting research on isolated and rinsed tissues.

Changes in SeMSC, glucosinolates and sulforaphane levels, and in proteome profile in broccoli (Brassica oleracea var. Italica) fertilized with sodium selenate.

PubMed

Sepúlveda, Ignacio; Barrientos, Herna; Mahn, Andrea; Moenne, Alejandra

2013-05-07

The aim of this work was to analyze the effect of sodium selenate fortification on the content of selenomethyl selenocysteine (SeMSC), total glucosinolates and sulforaphane, as well as the changes in protein profile of the inflorescences of broccoli (Brassica oleracea var. Italica). Two experimental groups were considered: plants treated with 100 μmol/L sodium selenate (final concentration in the pot) and control plants treated with water. Fortification began 2 weeks after transplantation and was repeated once a week during 10 weeks. Broccoli florets were harvested when they reached appropriate size. SeMSC content in broccoli florets increased significantly with sodium selenate fortification; but total glucosinolates and sulforaphane content as well as myrosinase activity were not affected. The protein profile of broccoli florets changed due to fortification with sodium selenate. Some proteins involved in general stress-responses were up-regulated, whereas down-regulated proteins were identified as proteins involved in protection against pathogens. This is the first attempt to evaluate the physiological effect of fortification with sodium selenate on broccoli at protein level. The results of this work will contribute to better understanding the metabolic processes related with selenium uptake and accumulation in broccoli.

Aerodynamic Performance Predictions of Single and Twin Jet Afterbodies

NASA Technical Reports Server (NTRS)

Carlson, John R.; Pao, S. Paul; Abdol-Hamid, Khaled S.; Jones, William T.

1995-01-01

The multiblock three-dimensional Navier-Stokes method PAB3D was utilized by the Component Integration Branch (formerly Propulsion Aerodynamics Branch) at the NASA-Langley Research Center in an international study sponsored by AGARD Working Group #17 for the assessment of the state-of-the-art of propulsion-airframe integration testing techniques and CFD prediction technologies. Three test geometries from ONERA involving fundamental flow physics and four geometries from NASA-LaRC involving realistic flow interactions of wing, body, tail, and jet plumes were chosen by the Working Group. An overview of results on four (1 ONERA and 3 LaRC) of the seven test cases is presented. External static pressures, integrated pressure drag and total drag were calculated for the Langley test cases and jet plume velocity profiles and turbulent viscous stresses were calculated for the ONERA test case. Only selected data from these calculations are presented in this paper. The complete data sets calculated by the participants will be presented in an AGARD summary report. Predicted surface static pressures compared favorably with experimental data for the Langley geometries. Predicted afterbody drag compared well with experiment. Predicted nozzle drag was typically low due to over-compression of the flow near the trailing edge. Total drag was typically high. Predicted jet plume quantities on the ONERA case compared generally well with data.

The relationship between mathematics and language: academic implications for children with specific language impairment and English language learners.

PubMed

Alt, Mary; Arizmendi, Genesis D; Beal, Carole R

2014-07-01

The present study examined the relationship between mathematics and language to better understand the nature of the deficit and the academic implications associated with specific language impairment (SLI) and academic implications for English language learners (ELLs). School-age children (N = 61; 20 SLI, 20 ELL, 21 native monolingual English [NE]) were assessed using a norm-referenced mathematics instrument and 3 experimental computer-based mathematics games that varied in language demands. Group means were compared with analyses of variance. The ELL group was less accurate than the NE group only when tasks were language heavy. In contrast, the group with SLI was less accurate than the groups with NE and ELLs on language-heavy tasks and some language-light tasks. Specifically, the group with SLI was less accurate on tasks that involved comparing numerical symbols and using visual working memory for patterns. However, there were no group differences between children with SLI and peers without SLI on language-light mathematics tasks that involved visual working memory for numerical symbols. Mathematical difficulties of children who are ELLs appear to be related to the language demands of mathematics tasks. In contrast, children with SLI appear to have difficulty with mathematics tasks because of linguistic as well as nonlinguistic processing constraints.

Impaired working memory capacity is not caused by failures of selective attention in schizophrenia.

PubMed

Erickson, Molly A; Hahn, Britta; Leonard, Carly J; Robinson, Benjamin; Gray, Brad; Luck, Steven J; Gold, James

2015-03-01

The cognitive impairments associated with schizophrenia have long been known to involve deficits in working memory (WM) capacity. To date, however, the causes of WM capacity deficits remain unknown. The present study examined selective attention impairments as a putative contributor to observed capacity deficits in this population. To test this hypothesis, we used an experimental paradigm that assesses the role of selective attention in WM encoding and has been shown to involve the prefrontal cortex and the basal ganglia. In experiment 1, participants were required to remember the locations of 3 or 5 target items (red circles). In another condition, 3-target items were accompanied by 2 distractor items (yellow circles), which participants were instructed to ignore. People with schizophrenia (PSZ) exhibited significant impairment in memory for the locations of target items, consistent with reduced WM capacity, but PSZ and healthy control subjects did not differ in their ability to filter the distractors. This pattern was replicated in experiment 2 for distractors that were more salient. Taken together, these results demonstrate that reduced WM capacity in PSZ is not attributable to a failure of filtering irrelevant distractors. © The Author 2014. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. All rights reserved. For permissions, please email: journals.permissions@oup.com.

[The consolidation of memory, one century on].

PubMed

Prado-Alcala, R A; Quirarte, G L

The theory of memory consolidation, based on the work published by Georg Elias Muller and Alfons Pilzecker over a century ago, continues to guide research into the neurobiology of memory, either directly or indirectly. In their classic monographic work, they concluded that fixing memory requires the passage of time (consolidation) and that memory is vulnerable during this period of consolidation, as symptoms of amnesia appear when brain functioning is interfered with before the consolidation process is completed. Most of the experimental data concerning this phenomenon strongly support the theory. In this article we present a review of experiments that have made it possible to put forward a model that explains the amnesia produced in conventional learning conditions, as well as another model related to the protection of memory when the same instances of learning are submitted to a situation involving intensive training. Findings from relatively recent studies have shown that treatments that typically produce amnesia when they are administered immediately after a learning experience (during the period in which the memory would be consolidating itself) no longer have any effect when the instances of learning involve a relatively large number of trials or training sessions, or relatively high intensity aversive events. These results are not congruent with the prevailing theories about consolidation.

Working memory load predicts visual search efficiency: Evidence from a novel pupillary response paradigm.

PubMed

Attar, Nada; Schneps, Matthew H; Pomplun, Marc

2016-10-01

An observer's pupil dilates and constricts in response to variables such as ambient and focal luminance, cognitive effort, the emotional stimulus content, and working memory load. The pupil's memory load response is of particular interest, as it might be used for estimating observers' memory load while they are performing a complex task, without adding an interruptive and confounding memory test to the protocol. One important task in which working memory's involvement is still being debated is visual search, and indeed a previous experiment by Porter, Troscianko, and Gilchrist (Quarterly Journal of Experimental Psychology, 60, 211-229, 2007) analyzed observers' pupil sizes during search to study this issue. These authors found that pupil size increased over the course of the search, and they attributed this finding to accumulating working memory load. However, since the pupil response is slow and does not depend on memory load alone, this conclusion is rather speculative. In the present study, we estimated working memory load in visual search during the presentation of intermittent fixation screens, thought to induce a low, stable level of arousal and cognitive effort. Using standard visual search and control tasks, we showed that this paradigm reduces the influence of non-memory-related factors on pupil size. Furthermore, we found an early increase in working memory load to be associated with more efficient search, indicating a significant role of working memory in the search process.

[The 100th anniversary of Gustav Wilhelm Störring's "Lectures on Psychopathology". A review of his early years].

PubMed

Steinberg, H; Künstler, U

2000-06-01

The aim of this essay is to retell the life and work of philosopher and psychiatrist Gustav Wilhelm Störring (1860-1946) during his early years in Leipzig and Erdmannshain. His "Lectures on Psychopathology and its Impact on Normal Psychology", written 100 years ago, are acknowledged as his most important work. With this book Störring stands in opposition to many of his contemporaries, which is illustrated with his concept of mania. In some aspects, however, his ideas coincide with those of other well-known psychiatrists such as Emil Kraepelin. Both were inclined to the idea that psychiatry and psychology could mutually stimulate each other. Störring's work in Wundt's laboratory of experimental psychology had a major impact on his work. Wundt's ideas gave impetus to a lot of his work and also influenced papers Störring was to write later on. Störring's biography is followed until 1902 when he was appointed professor of philosophy of Zurich University, in which his friend Ernst Meumann was substantially involved. In Leipzig Störring had started his work as Flechsig's assistant at the hospital of psychiatry and neurology of Leipzig University. In 1897 he founded his own sanitarium for mentally and neurologically ill in Erdmannshain, a village near Leipzig, which he managed together with his wife Marie, née Bonacker. With the help of Wundt Störring qualifies as a university lecturer. During the years regarded here, however, he got more and more attracted to philosophical matters, thus turning away from neurosciences. In time he started to regard his work as physician as nothing more than necessary for making his living. His relationship with Wundt, who together with his laboratory of experimental psychology had previously made him wish to come to Leipzig, cooled down, at least on the part of the first. That puts an end to Störring's early years not only from the point of view of his biography but also from his work.

BPC 157's effect on healing.

PubMed

Seiwerth, S; Sikiric, P; Grabarevic, Z; Zoricic, I; Hanzevacki, M; Ljubanovic, D; Coric, V; Konjevoda, P; Petek, M; Rucman, R; Turkovic, B; Perovic, D; Mikus, D; Jandrijevic, S; Medvidovic, M; Tadic, T; Romac, B; Kos, J; Peric, J; Kolega, Z

1997-01-01

The 15 amino acid agent BPC 157, showing a wide range of organoprotective action in different experimental models, was used in our experiments in order to establish its influence on different elements connected with the healing process. Elements thought to be of greatest importance in the process of healing are formation of granulation tissue, angiogenesis and production of collagen. In our work we tested the influence of BPC 157 on: granulation tissue and collagen formation, on angiogenesis as well as on tensile strength development, using three experimental rat models: 1) skin incisional wounds; 2) colon-colon anastomoses; and 3) angiogenesis model with synthetic sponge implantation. The specimens were histologically assessed for collagen, reticulin and blood vessels using scoring and morphometry. In all experiments significant differences between BPC 157-treated animals and controls were found, showing a strong, promoting involvement of BPC in the healing process. It is worth noting that these effects were achieved by different routes of application, including intragastric and local, making BPC 157 a potentially useful therapeutic agent.

Adsorbate-induced lattice deformation in IRMOF-74 series

DOE PAGES

Jawahery, Sudi; Simon, Cory M.; Braun, Efrem; ...

2017-01-09

Here, IRMOF-74 analogues are among the most widely studied metal-organic frameworks (MOFs) for adsorption applications because of their one-dimensional channels and high metal density. Most studies involving the IRMOF-74 series assume that the crystal lattice is rigid. This assumption guides the interpretation of experimental data, as changes in the crystal symmetry have so far been ignored as a possibility in the literature. Here, we report a deformation pattern, induced by the adsorption of argon, for IRMOF-74-V. This work has two main implications. First, we use molecular simulations to demonstrate that the IRMOF-74 series undergoes a deformation that is similar tomore » the mechanism behind breathing MOFs, but is unique because the deformation pattern extends beyond a single unit cell of the original structure. Second, we provide an alternative interpretation of experimental small-angle X-ray scattering profiles of these systems, which changes how we view the fundamentals of adsorption in this MOF series.« less

Teaching psychology to jurists: initiatives and reactions prior to World War I.

PubMed

Mülberger, Annette

2009-05-01

This article deals with the kind of psychology suggested for jurists that was thought to be necessary training for their work. An analysis of the content of two textbooks by Otto Lipmann and Karl Marbe reveals that such teaching activity involves two different levels of historical analysis. On the one hand, it relates to experimental research done by psychologists on law-related issues; on the other, it concerns the professional experience psychologists accumulated by acting as expert witnesses in court. The paper investigates how psychologists presented psychology to jurists, which methods and theories they suggested as being essential for juristic training and professional performance, and whether jurists appreciated these materials and efforts. These inquiries are embedded in the debate on the history of criminal psychology, taking into account the European, particularly the German, context. The author shows how specific historical developments led to an increased exchange between experimental psychology and criminal law during the first decades of the 20th century.

Daniel Sennert, The Philosophical Hen, and The Epistolary Quest for a (Nearly-) Universal Medicine.

PubMed

Klein, Joel A

2015-02-01

This article explores the Wittenberg Professor Daniel Sennert's (1572-1637) pursuit of nearly universal medicines made from noble metals, which he described in his published works and in private correspondence with his brother-in-law, Michael Döring. Of the medicaments that Sennert sought, one called the Philosophical Hen was especially interesting, and involved feeding a hen silver or gold during propitious astrological conjunctions. Sennert's support of this experiment was rooted in his obsession with experience and can be partially explained by looking to an extensive tradition of natural philosophy and natural history. Sennert explained such nearly universal medicines according to the rational principles of academic medicine, arguing that they strengthened the body's innate heat or acted as universal purgatives. From Sennert's candid epistles, we receive a more historicised portrait of the collaborative experimental process by which chymical medicines were conceptualised and tested, and how the consequences of experimental failure and perceived credulity could be increased scepticism.

Optical properties of azobenzene-functionalized self-assembled monolayers: Intermolecular coupling and many-body interactions

NASA Astrophysics Data System (ADS)

Cocchi, Caterina; Moldt, Thomas; Gahl, Cornelius; Weinelt, Martin; Draxl, Claudia

2016-12-01

In a joint theoretical and experimental work, the optical properties of azobenzene-functionalized self-assembled monolayers (SAMs) are studied at different molecular packing densities. Our results, based on density-functional and many-body perturbation theory, as well as on differential reflectance (DR) spectroscopy, shed light on the microscopic mechanisms ruling photo-absorption in these systems. While the optical excitations are intrinsically excitonic in nature, regardless of the molecular concentration, in densely packed SAMs intermolecular coupling and local-field effects are responsible for a sizable weakening of the exciton binding strength. Through a detailed analysis of the character of the electron-hole pairs, we show that distinct excitations involved in the photo-isomerization at low molecular concentrations are dramatically broadened by intermolecular interactions. Spectral shifts in the calculated DR spectra are in good agreement with the experimental results. Our findings represent an important step forward to rationalize the excited-state properties of these complex materials.

Phosphorus vacancy cluster model for phosphorus diffusion gettering of metals in Si

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chen, Renyu; Trzynadlowski, Bart; Dunham, Scott T.

2014-02-07

In this work, we develop models for the gettering of metals in silicon by high phosphorus concentration. We first performed ab initio calculations to determine favorable configurations of complexes involving phosphorus and transition metals (Fe, Cu, Cr, Ni, Ti, Mo, and W). Our ab initio calculations found that the P{sub 4}V cluster, a vacancy surrounded by 4 nearest-neighbor phosphorus atoms, which is the most favorable inactive P species in heavily doped Si, strongly binds metals such as Cu, Cr, Ni, and Fe. Based on the calculated binding energies, we build continuum models to describe the P deactivation and Fe getteringmore » processes with model parameters calibrated against experimental data. In contrast to previous models assuming metal-P{sub 1}V or metal-P{sub 2}V as the gettered species, the binding of metals to P{sub 4}V satisfactorily explains the experimentally observed strong gettering behavior at high phosphorus concentrations.« less

Using Separable Nonnegative Matrix Factorization Techniques for the Analysis of Time-Resolved Raman Spectra

NASA Astrophysics Data System (ADS)

Luce, R.; Hildebrandt, P.; Kuhlmann, U.; Liesen, J.

2016-09-01

The key challenge of time-resolved Raman spectroscopy is the identification of the constituent species and the analysis of the kinetics of the underlying reaction network. In this work we present an integral approach that allows for determining both the component spectra and the rate constants simultaneously from a series of vibrational spectra. It is based on an algorithm for non-negative matrix factorization which is applied to the experimental data set following a few pre-processing steps. As a prerequisite for physically unambiguous solutions, each component spectrum must include one vibrational band that does not significantly interfere with vibrational bands of other species. The approach is applied to synthetic "experimental" spectra derived from model systems comprising a set of species with component spectra differing with respect to their degree of spectral interferences and signal-to-noise ratios. In each case, the species involved are connected via monomolecular reaction pathways. The potential and limitations of the approach for recovering the respective rate constants and component spectra are discussed.

Nonequilibrium Transport and the Bernoulli Effect of Electrons in a Two-Dimensional Electron Gas

NASA Astrophysics Data System (ADS)

Kaya, Ismet I.

2013-02-01

Nonequilibrium transport of charged carriers in a two-dimensional electron gas is summarized from an experimental point of view. The transport regime in which the electron-electron interactions are enhanced at high bias leads to a range of striking effects in a two-dimensional electron gas. This regime of transport is quite different than the ballistic transport in which particles propagate coherently with no intercarrier energy transfer and the diffusive transport in which the momentum of the electron system is lost with the involvement of the phonons. Quite a few hydrodynamic phenomena observed in classical gasses have the electrical analogs in the current flow. When intercarrier scattering events dominate the transport, the momentum sharing via narrow angle scattering among the hot and cold electrons lead to negative resistance and electron pumping which can be viewed as the analog of the Bernoulli-Venturi effect observed classical gasses. The recent experimental findings and the background work in the field are reviewed.

Comparative study of glass tube and mist chamber sampling techniques for the analysis of gaseous carbonyl compounds

NASA Astrophysics Data System (ADS)

François, Stéphanie; Perraud, Véronique; Pflieger, Maryline; Monod, Anne; Wortham, Henri

In this work, glass tube and mist chamber sampling techniques using 2,4-dinitrophenylhydrazine as derivative agent for the analysis of gaseous carbonyl compounds are compared. Trapping efficiencies of formaldehyde, acetaldehyde, propionaldehyde, acetone, acrolein, glyoxal, crotonaldehyde, benzaldehyde, butyraldehyde and valeraldehyde are experimentally determined using a gas-phase generator. In addition to generalise our results to all atmospheric gaseous compounds and derivative agents, theoretical trapping efficiencies and enrichment factors are expressed taking into account mechanisms involved in the two kinds of traps. Theoretical and experimental results show that, as expected, the trapping efficiencies of the glass tube depend mainly on solubility of compounds. The results provide new information and better understanding of phenomena occurring in the mist chamber and the ability of this sampler to concentrate the samples. Hence, the mist chamber is the more convenient sampling method when the trapping is associated to a fast derivatisation of the compounds and the glass tube technique must be used to trap atmospheric compounds without simultaneous derivatisation.