Communication networks of men facing a diagnosis of prostate cancer.

PubMed

Brown, Dot; Oetzel, John; Henderson, Alison

2016-11-01

This study seeks to identify the factors that shape the communication networks of men who face a potential diagnosis of prostate cancer, and how these factors relate to their disclosure about their changing health status. Men facing a potential diagnosis of prostate cancer are in a challenging situation; the support benefits of disclosing their changing health status to others in their communication networks is set against a backdrop of the potential stigma and uncertainty of the diagnosis. All men on a prostate biopsy waiting list were eligible for inclusion in an exploratory and interpretive study. Semi-structured interviews with 40 men explored their network structures and disclosure of health information. Thematic analysis highlighted the factors which contributed to their network structures and their disclosure about their health status. Four network factors shaped men's perspectives about disclosing their health status: (1) tie strength, comprising both strong and weak ties; (2) knowledgeable others, with a focus on medical professionals in the family; (3) homophily, which included other individuals with a similar medical condition; and (4) geographical proximity, with a preference for face-to-face communication. Communication networks influence men's disclosure of their health status and in particular weak ties with medical knowledge have an important role. Men who use the potential for support in their networks may experience improved psychosocial outcomes. Using these four network factors-tie strength, knowledgeable others, homophily or geographical proximity-to forecast men's willingness to disclose helps identify men who lack potential support and so are at risk of poor psychosocial health. Those with few strong ties or knowledgeable others in their networks may be in the at-risk cohort. The support provided in communication networks complements formal medical care from nurses and other health professionals, and encouraging patients to use their communication networks improves the psychosocial health of the men themselves, their partners and their families. © 2016 John Wiley & Sons Ltd.

Weather Effects on Mobile Social Interactions: A Case Study of Mobile Phone Users in Lisbon, Portugal

PubMed Central

Phithakkitnukoon, Santi; Leong, Tuck W.; Smoreda, Zbigniew; Olivier, Patrick

2012-01-01

The effect of weather on social interactions has been explored through the analysis of a large mobile phone use dataset. Time spent on phone calls, numbers of connected social ties, and tie strength were used as proxies for social interactions; while weather conditions were characterized in terms of temperature, relative humidity, air pressure, and wind speed. Our results are based on the analysis of a full calendar year of data for 22,696 mobile phone users (53.2 million call logs) in Lisbon, Portugal. The results suggest that different weather parameters have correlations to the level and character of social interactions. We found that although weather did not show much influence upon people's average call duration, the likelihood of longer calls was found to increase during periods of colder weather. During periods of weather that were generally considered to be uncomfortable (i.e., very cold/warm, very low/high air pressure, and windy), people were found to be more likely to communicate with fewer social ties. Despite this tendency, we found that people are more likely to maintain their connections with those they have strong ties with much more than those of weak ties. This study sheds new light on the influence of weather conditions on social relationships and how mobile phone data can be used to investigate the influence of environmental factors on social dynamics. PMID:23071523

Weather effects on mobile social interactions: a case study of mobile phone users in Lisbon, Portugal.

PubMed

Phithakkitnukoon, Santi; Leong, Tuck W; Smoreda, Zbigniew; Olivier, Patrick

2012-01-01

The effect of weather on social interactions has been explored through the analysis of a large mobile phone use dataset. Time spent on phone calls, numbers of connected social ties, and tie strength were used as proxies for social interactions; while weather conditions were characterized in terms of temperature, relative humidity, air pressure, and wind speed. Our results are based on the analysis of a full calendar year of data for 22,696 mobile phone users (53.2 million call logs) in Lisbon, Portugal. The results suggest that different weather parameters have correlations to the level and character of social interactions. We found that although weather did not show much influence upon people's average call duration, the likelihood of longer calls was found to increase during periods of colder weather. During periods of weather that were generally considered to be uncomfortable (i.e., very cold/warm, very low/high air pressure, and windy), people were found to be more likely to communicate with fewer social ties. Despite this tendency, we found that people are more likely to maintain their connections with those they have strong ties with much more than those of weak ties. This study sheds new light on the influence of weather conditions on social relationships and how mobile phone data can be used to investigate the influence of environmental factors on social dynamics.

Strong Ties, Weak Ties, and Human Capital: Latino Immigrant Employment outside the Enclave

ERIC Educational Resources Information Center

Pfeffer, Max J.; Parra, Pilar A.

2009-01-01

This study focuses on the role of social ties and human capital in the integration of Latino immigrants into the local economy. This analysis extends earlier research by focusing on more rural contexts with limited labor-market opportunities and less access to social resources provided by coethnics. We reconsider conclusions of previous studies by…

The Strength of Strong Ties for Older Rural Adults: Regional Distinctions in the Relationship between Social Interaction and Subjective Well-Being

ERIC Educational Resources Information Center

Mair, Christine A.; Thivierge-Rikard, R. V.

2010-01-01

Classic and contemporary sociological theories suggest that social interaction differs in rural and urban areas. Intimate, informal interactions (strong ties) are theorized to characterize rural areas while urban areas may possess more formal and rationalized interactions (weak ties). Aging and social support literature stresses social interaction…

Perceived Stress in Online Prostate Cancer Community Participants: Examining Relationships with Stigmatization, Social Support Network Preference, and Social Support Seeking.

PubMed

Rising, Camella J; Bol, Nadine; Burke-Garcia, Amelia; Rains, Stephen; Wright, Kevin B

2017-06-01

Men with prostate cancer often need social support to help them cope with illness-related physiological and psychosocial challenges. Whether those needs are met depends on receiving support optimally matched to their needs. This study examined relationships between perceived stress, prostate cancer-related stigma, weak-tie support preference, and online community use for social support in a survey of online prostate cancer community participants (n = 149). Findings revealed a positive relationship between stigma and perceived stress. This relationship, however, was moderated by weak-tie support preference and online community use for social support. Specifically, stigma was positively related to perceived stress when weak-tie support was preferred. Analyses also showed a positive relationship between stigma and perceived stress in those who used their online community for advice or emotional support. Health communication scholars should work collaboratively with diagnosed men, clinicians, and online community administrators to develop online interventions that optimally match social support needs.

A small world of weak ties provides optimal global integration of self-similar modules in functional brain networks.

PubMed

Gallos, Lazaros K; Makse, Hernán A; Sigman, Mariano

2012-02-21

The human brain is organized in functional modules. Such an organization presents a basic conundrum: Modules ought to be sufficiently independent to guarantee functional specialization and sufficiently connected to bind multiple processors for efficient information transfer. It is commonly accepted that small-world architecture of short paths and large local clustering may solve this problem. However, there is intrinsic tension between shortcuts generating small worlds and the persistence of modularity, a global property unrelated to local clustering. Here, we present a possible solution to this puzzle. We first show that a modified percolation theory can define a set of hierarchically organized modules made of strong links in functional brain networks. These modules are "large-world" self-similar structures and, therefore, are far from being small-world. However, incorporating weaker ties to the network converts it into a small world preserving an underlying backbone of well-defined modules. Remarkably, weak ties are precisely organized as predicted by theory maximizing information transfer with minimal wiring cost. This trade-off architecture is reminiscent of the "strength of weak ties" crucial concept of social networks. Such a design suggests a natural solution to the paradox of efficient information flow in the highly modular structure of the brain.

"I did a lot of Googling": A qualitative study of exclusive breastfeeding support through social media.

PubMed

Alianmoghaddam, Narges; Phibbs, Suzanne; Benn, Cheryl

2018-06-16

Little qualitative research has been done to explore the quality of breastfeeding support through social media in New Zealand. This article aims to explore the influence of social media on exclusive breastfeeding practice. A qualitative study involving face-to-face postpartum interviews with 30 mothers who were recruited from the lower North Island of New Zealand. Each participant was followed via short monthly audio-recorded telephone interviews until giving up exclusive breastfeeding or until six months after the birth. The theories "strength of weak ties" and "landscapes of care" are applied to the thematic analysis of the interview material to illuminate the influence of social media on breastfeeding practices. Qualitative analysis of the interview material identified four themes: 1) Mothers need reliable online infant feeding information; 2) Smartphone apps can be a good option for promoting breastfeeding; 3) Information is accessed through weak ties among breastfeeding mothers on Facebook, and 4) the utility of geographically distant infant feeding support via Skype. Most participants sourced post-partum information and advice to support breastfeeding through the Internet, while those with geographically distant family members accessed emotional and practical breastfeeding support via Skype. Breastfeeding advocates should use social media to promote and support exclusive breast-feeding practice. The influence of social media on breastfeeding points to the relational nature of breastfeeding which is embedded in 'real' world and virtual social networks as well as the cultural, geographic and social contexts of a mother's life. Copyright © 2018 Australian College of Midwives. Published by Elsevier Ltd. All rights reserved.

Quantifying the impact of weak, strong, and super ties in scientific careers

PubMed Central

Petersen, Alexander Michael

2015-01-01

Scientists are frequently faced with the important decision to start or terminate a creative partnership. This process can be influenced by strategic motivations, as early career researchers are pursuers, whereas senior researchers are typically attractors, of new collaborative opportunities. Focusing on the longitudinal aspects of scientific collaboration, we analyzed 473 collaboration profiles using an egocentric perspective that accounts for researcher-specific characteristics and provides insight into a range of topics, from career achievement and sustainability to team dynamics and efficiency. From more than 166,000 collaboration records, we quantify the frequency distributions of collaboration duration and tie strength, showing that collaboration networks are dominated by weak ties characterized by high turnover rates. We use analytic extreme value thresholds to identify a new class of indispensable super ties, the strongest of which commonly exhibit >50% publication overlap with the central scientist. The prevalence of super ties suggests that they arise from career strategies based upon cost, risk, and reward sharing and complementary skill matching. We then use a combination of descriptive and panel regression methods to compare the subset of publications coauthored with a super tie to the subset without one, controlling for pertinent features such as career age, prestige, team size, and prior group experience. We find that super ties contribute to above-average productivity and a 17% citation increase per publication, thus identifying these partnerships—the analog of life partners—as a major factor in science career development. PMID:26261301

Gauge Bosons--The Ties That Bind.

ERIC Educational Resources Information Center

Hill, Christopher T.

1982-01-01

Discusses four basic forces/interactions in nature (strong force, weak force, electromagnetic force and gravity), associated with elementary particles. Focuses on "gauge bosons" (for example, photons), thought to account for strong, weak, and electromagnetic forces. (Author/JN)

The strength-of-weak-ties perspective on creativity: a comprehensive examination and extension.

PubMed

Baer, Markus

2010-05-01

Disentangling the effects of weak ties on creativity, the present study separated, both theoretically and empirically, the effects of the size and strength of actors' idea networks and examined their joint impact while simultaneously considering the separate, moderating role of network diversity. I hypothesized that idea networks of optimal size and weak strength were more likely to boost creativity when they afforded actors access to a wide range of different social circles. In addition, I examined whether the joint effects of network size, strength, and diversity on creativity were further qualified by the openness to experience personality dimension. As expected, results indicated that actors were most creative when they maintained idea networks of optimal size, weak strength, and high diversity and when they scored high on the openness dimension. The implications of these results are discussed. PsycINFO Database Record (c) 2010 APA, all rights reserved.

Social Capital and International Migration from Latin America

PubMed Central

Massey, Douglas S.; Aysa-Lastra, María

2011-01-01

We combine data from the Latin American Migration Project and the Mexican Migration Project to estimate models predicting the likelihood of taking of first and later trips to the United States from five nations: Mexico, the Dominican Republic, Costa Rica, Nicaragua, and Peru. The models test specific hypotheses about the effects of social capital on international migration and how these effects vary with respect to contextual factors. Our findings confirm the ubiquity of migrant networks and the universality of social capital effects throughout Latin America. They also reveal how the sizes of these effects are not uniform across settings. Social capital operates more powerfully on first as opposed to later trips and interacts with the cost of migration. In addition, effects are somewhat different when considering individual social capital (measuring strong ties) and community social capital (measuring weak ties). On first trips, the effect of strong ties in promoting migration increases with distance whereas the effect of weak ties decreases with distance. On later trips, the direction of effects for both individual and community social capital is negative for long distances but positive for short distances. PMID:21915379

A network approach for researching partnerships in health.

PubMed

Lewis, Jenny M

2005-10-07

The last decade has witnessed a significant move towards new modes of governing that are based on coordination and collaboration. In particular, local level partnerships have been widely introduced around the world. There are few comprehensive approaches for researching the effects of these partnerships. The aim of this paper is to outline a network approach that combines structure and agency based explanations to research partnerships in health. Network research based on two Primary Care Partnerships (PCPs) in Victoria is used to demonstrate the utility of this approach. The paper examines multiple types of ties between people (structure), and the use and value of relationships to partners (agency), using interviews with the people involved in two PCPs--one in metropolitan Melbourne and one in a rural area. Network maps of ties based on work, strategic information and policy advice, show that there are many strong connections in both PCPs. Not surprisingly, PCP staff are central and highly connected. Of more interest are the ties that are dependent on these dedicated partnership staff, as they reveal which actors become weakly linked or disconnected without them. Network measures indicate that work ties are the most dispersed and strategic information ties are the most concentrated around fewer people. Divisions of general practice are weakly linked, while local government officials and Department of Human Services (DHS) regional staff appear to play important bridging roles. Finally, the relationships between partners have changed and improved, and most of those interviewed value their new or improved links with partners. Improving service coordination and health promotion planning requires engaging people and building strong relationships. Mapping ties is a useful means for assessing the strengths and weaknesses of partnerships, and network analysis indicates concentration and dispersion, the importance of particular individuals, and the points at which they will fragment. A narrative approach adds an assessment of whether the partnerships are being used and valued. The approach outlined here, which examines structure and agency as separate but related explanations, has much to offer in examining partnerships.

Latent Class Models in action: bridging social capital & Internet usage.

PubMed

Neves, Barbara Barbosa; Fonseca, Jaime R S

2015-03-01

This paper explores how Latent Class Models (LCM) can be applied in social research, when the basic assumptions of regression models cannot be validated. We examine the usefulness of this method with data collected from a study on the relationship between bridging social capital and the Internet. Social capital is defined here as the resources that are potentially available in one's social ties. Bridging is a dimension of social capital, usually related to weak ties (acquaintances), and a source of instrumental resources such as information. The study surveyed a stratified random sample of 417 inhabitants of Lisbon, Portugal. We used LCM to create the variable bridging social capital, but also to estimate the relationship between bridging social capital and Internet usage when we encountered convergence problems with the logistic regression analysis. We conclude by showing a positive relationship between bridging and Internet usage, and by discussing the potential of LCM for social science research. Copyright © 2014 Elsevier Inc. All rights reserved.

From calls to communities: a model for time-varying social networks

NASA Astrophysics Data System (ADS)

Laurent, Guillaume; Saramäki, Jari; Karsai, Márton

2015-11-01

Social interactions vary in time and appear to be driven by intrinsic mechanisms that shape the emergent structure of social networks. Large-scale empirical observations of social interaction structure have become possible only recently, and modelling their dynamics is an actual challenge. Here we propose a temporal network model which builds on the framework of activity-driven time-varying networks with memory. The model integrates key mechanisms that drive the formation of social ties - social reinforcement, focal closure and cyclic closure, which have been shown to give rise to community structure and small-world connectedness in social networks. We compare the proposed model with a real-world time-varying network of mobile phone communication, and show that they share several characteristics from heterogeneous degrees and weights to rich community structure. Further, the strong and weak ties that emerge from the model follow similar weight-topology correlations as real-world social networks, including the role of weak ties.

A network approach for researching partnerships in health

PubMed Central

Lewis, Jenny M

2005-01-01

Background The last decade has witnessed a significant move towards new modes of governing that are based on coordination and collaboration. In particular, local level partnerships have been widely introduced around the world. There are few comprehensive approaches for researching the effects of these partnerships. The aim of this paper is to outline a network approach that combines structure and agency based explanations to research partnerships in health. Network research based on two Primary Care Partnerships (PCPs) in Victoria is used to demonstrate the utility of this approach. The paper examines multiple types of ties between people (structure), and the use and value of relationships to partners (agency), using interviews with the people involved in two PCPs – one in metropolitan Melbourne and one in a rural area. Results Network maps of ties based on work, strategic information and policy advice, show that there are many strong connections in both PCPs. Not surprisingly, PCP staff are central and highly connected. Of more interest are the ties that are dependent on these dedicated partnership staff, as they reveal which actors become weakly linked or disconnected without them. Network measures indicate that work ties are the most dispersed and strategic information ties are the most concentrated around fewer people. Divisions of general practice are weakly linked, while local government officials and Department of Human Services (DHS) regional staff appear to play important bridging roles. Finally, the relationships between partners have changed and improved, and most of those interviewed value their new or improved links with partners. Conclusion Improving service coordination and health promotion planning requires engaging people and building strong relationships. Mapping ties is a useful means for assessing the strengths and weaknesses of partnerships, and network analysis indicates concentration and dispersion, the importance of particular individuals, and the points at which they will fragment. A narrative approach adds an assessment of whether the partnerships are being used and valued. The approach outlined here, which examines structure and agency as separate but related explanations, has much to offer in examining partnerships. PMID:16209718

A small world of weak ties provides optimal global integration of self-similar modules in functional brain networks

PubMed Central

Gallos, Lazaros K.; Makse, Hernán A.; Sigman, Mariano

2012-01-01

The human brain is organized in functional modules. Such an organization presents a basic conundrum: Modules ought to be sufficiently independent to guarantee functional specialization and sufficiently connected to bind multiple processors for efficient information transfer. It is commonly accepted that small-world architecture of short paths and large local clustering may solve this problem. However, there is intrinsic tension between shortcuts generating small worlds and the persistence of modularity, a global property unrelated to local clustering. Here, we present a possible solution to this puzzle. We first show that a modified percolation theory can define a set of hierarchically organized modules made of strong links in functional brain networks. These modules are “large-world” self-similar structures and, therefore, are far from being small-world. However, incorporating weaker ties to the network converts it into a small world preserving an underlying backbone of well-defined modules. Remarkably, weak ties are precisely organized as predicted by theory maximizing information transfer with minimal wiring cost. This trade-off architecture is reminiscent of the “strength of weak ties” crucial concept of social networks. Such a design suggests a natural solution to the paradox of efficient information flow in the highly modular structure of the brain. PMID:22308319

For Whom Money Matters Less: Social Connectedness as a Resilience Resource in the UK.

PubMed

Richards, Lindsay

The current literature shows that both absolute and relative income are important for happiness, but there is little work emphasising how the strength of the relationship is dependent on personal and social factors. I hypothesise that social connectedness influences the money-happiness relationship because the effect of money is in part felt through the acquisition of social status, whereas status (and associated psychological benefits such as self-worth) can alternatively be gained through social connectedness. In particular, it is theorised that 'weak ties' when co-existing with good quality informal ties have a separable and additional benefit to subjective well-being, and that it is the socially isolated who have the most to gain from doing well financially. Social connectedness is conceptualised as a 'resilience resource' which has a buffering effect on subjective well-being. Data from the British Household Panel Survey are used, first to establish a measurement schema of connectedness using latent class analysis, and secondly in a multilevel model of life satisfaction with observations from seven consecutive years nested within individuals. The results show that connectedness makes a larger difference to satisfaction in times of financial stress, and that the satisfaction of the socially isolated can 'catch up' to some degree with those with larger networks when things are going well financially. The findings also confirm that those for whom money makes the smallest contribution to happiness are those with both strong and weak ties. Weak ties have an additional benefit compared to having strong ties alone. In summary, connectedness has the power to narrow the well-being gap that exists between times of financial struggle and times of relative comfort. It suggests that the psychological benefits of social integration have the capacity to displace money as a source of status and self-worth, and similarly that the importance of money may be exaggerated where these psychological gains are not available through other domains of life.

Grandparents' resources and grandchildren's schooling: Does grandparental involvement moderate the grandparent effect?

PubMed

Bol, Thijs; Kalmijn, Matthijs

2016-01-01

Recent studies have argued that grandparents have a direct effect on grandchildren's achievements, net of parental resources. However, little is known about the underlying mechanisms. One explanation is that grandchildren can benefit from the cultural resources that grandparents transmit to their grandchildren. If this is the case, one would expect strong effects in families where grandparents are highly involved in the lives of their grandchildren and weak or no effects in other families. Using new nationally representative survey data on three generations in the Netherlands, we examine if and how grandchildren's educational attainment is affected by three grandparental resources: education, occupational status, and cultural resources. We explore how these effects vary by the strength of the tie between grandparent and grandchild. We find no evidence for a main direct grandparental effect, nor do we find interactions with the strength of the tie between grandparent and grandchild. These null-findings are discussed in light of the mixed body of evidence that has been accumulated in the literature and contemporary theorizing on grandparenting. Copyright © 2015 Elsevier Inc. All rights reserved.

Geographies of an Online Social Network.

PubMed

Lengyel, Balázs; Varga, Attila; Ságvári, Bence; Jakobi, Ákos; Kertész, János

2015-01-01

How is online social media activity structured in the geographical space? Recent studies have shown that in spite of earlier visions about the "death of distance", physical proximity is still a major factor in social tie formation and maintenance in virtual social networks. Yet, it is unclear, what are the characteristics of the distance dependence in online social networks. In order to explore this issue the complete network of the former major Hungarian online social network is analyzed. We find that the distance dependence is weaker for the online social network ties than what was found earlier for phone communication networks. For a further analysis we introduced a coarser granularity: We identified the settlements with the nodes of a network and assigned two kinds of weights to the links between them. When the weights are proportional to the number of contacts we observed weakly formed, but spatially based modules resemble to the borders of macro-regions, the highest level of regional administration in the country. If the weights are defined relative to an uncorrelated null model, the next level of administrative regions, counties are reflected.

Geographies of an Online Social Network

PubMed Central

Lengyel, Balázs; Varga, Attila; Ságvári, Bence; Jakobi, Ákos; Kertész, János

2015-01-01

How is online social media activity structured in the geographical space? Recent studies have shown that in spite of earlier visions about the “death of distance”, physical proximity is still a major factor in social tie formation and maintenance in virtual social networks. Yet, it is unclear, what are the characteristics of the distance dependence in online social networks. In order to explore this issue the complete network of the former major Hungarian online social network is analyzed. We find that the distance dependence is weaker for the online social network ties than what was found earlier for phone communication networks. For a further analysis we introduced a coarser granularity: We identified the settlements with the nodes of a network and assigned two kinds of weights to the links between them. When the weights are proportional to the number of contacts we observed weakly formed, but spatially based modules resemble to the borders of macro-regions, the highest level of regional administration in the country. If the weights are defined relative to an uncorrelated null model, the next level of administrative regions, counties are reflected. PMID:26359668

Social Features of Online Networks: The Strength of Intermediary Ties in Online Social Media

PubMed Central

Grabowicz, Przemyslaw A.; Ramasco, José J.; Moro, Esteban; Pujol, Josep M.; Eguiluz, Victor M.

2012-01-01

An increasing fraction of today's social interactions occur using online social media as communication channels. Recent worldwide events, such as social movements in Spain or revolts in the Middle East, highlight their capacity to boost people's coordination. Online networks display in general a rich internal structure where users can choose among different types and intensity of interactions. Despite this, there are still open questions regarding the social value of online interactions. For example, the existence of users with millions of online friends sheds doubts on the relevance of these relations. In this work, we focus on Twitter, one of the most popular online social networks, and find that the network formed by the basic type of connections is organized in groups. The activity of the users conforms to the landscape determined by such groups. Furthermore, Twitter's distinction between different types of interactions allows us to establish a parallelism between online and offline social networks: personal interactions are more likely to occur on internal links to the groups (the weakness of strong ties); events transmitting new information go preferentially through links connecting different groups (the strength of weak ties) or even more through links connecting to users belonging to several groups that act as brokers (the strength of intermediary ties). PMID:22247773

Impact of weak social ties and networks on poor sleep quality: A case study of Iranian employees.

PubMed

Masoudnia, Ebrahim

2015-12-01

The poor sleep quality is one of the major risk factors of somatic, psychiatric and social disorders and conditions as well as the major predictors of quality of employees' performance. The previous studies in Iran had neglected the impacts of social factors including social networks and ties on adults sleep quality. Thus, the aim of the current research was to determine the relationship between social networks and adult employees' sleep quality. This study was conducted with a correlational and descriptive design. Data were collected from 360 participants (183 males and 177 females) who were employed in Yazd public organizations in June and July of 2014. These samples were selected based on random sampling method. In addition, the measuring tools were the Pittsburgh Sleep Quality Index (PSQI) and Social Relations Inventory (SRI). Based on the results, the prevalence rate of sleep disorder among Iranian adult employees was 63.1% (total PSQI>5). And, after controlling for socio-demographic variables, there was significant difference between individuals with strong and poor social network and ties in terms of overall sleep quality (p<.01), subjective sleep quality (p<.01), habitual sleep efficiency (p<.05), and daytime dysfunction (p<.01). The results also revealed that the employees with strong social network and ties had better overall sleep quality, had the most habitual sleep efficiency, and less daytime dysfunction than employees with poor social network and ties. It can be implied that the weak social network and ties serve as a risk factor for sleep disorders or poor sleep quality for adult employees. Therefore, the social and behavioral interventions seem essential to improve the adult's quality sleep. Copyright © 2015 Elsevier B.V. All rights reserved.

Do Social Ties Affect Our Health? Exploring the Biology of Relationships

MedlinePlus

... Do Social Ties Affect Our Health? Exploring the Biology of Relationships En español Send us your comments ... neighbors, or others, social connections can influence our biology and well-being. Wide-ranging research suggests that ...

Breaking up Isn't Hard to Do: Exploring the Dissolution of Teachers' and School Leaders' Work-Related Ties

ERIC Educational Resources Information Center

Spillane, James P.; Shirrell, Matthew

2017-01-01

Purpose: School leaders are central to the development of work-related ties among school staff. Although prior work has examined the predictors of the presence of work-related ties, little is known about the breakup or dissolution of ties among school staff. This study examines the extent of tie dissolution among school staff, as well as both the…

Modelling the Evolution of Social Structure

PubMed Central

Sutcliffe, A. G.; Dunbar, R. I. M.; Wang, D.

2016-01-01

Although simple social structures are more common in animal societies, some taxa (mainly mammals) have complex, multi-level social systems, in which the levels reflect differential association. We develop a simulation model to explore the conditions under which multi-level social systems of this kind evolve. Our model focuses on the evolutionary trade-offs between foraging and social interaction, and explores the impact of alternative strategies for distributing social interaction, with fitness criteria for wellbeing, alliance formation, risk, stress and access to food resources that reward social strategies differentially. The results suggest that multi-level social structures characterised by a few strong relationships, more medium ties and large numbers of weak ties emerge only in a small part of the overall fitness landscape, namely where there are significant fitness benefits from wellbeing and alliance formation and there are high levels of social interaction. In contrast, ‘favour-the-few’ strategies are more competitive under a wide range of fitness conditions, including those producing homogeneous, single-level societies of the kind found in many birds and mammals. The simulations suggest that the development of complex, multi-level social structures of the kind found in many primates (including humans) depends on a capacity for high investment in social time, preferential social interaction strategies, high mortality risk and/or differential reproduction. These conditions are characteristic of only a few mammalian taxa. PMID:27427758

Family Ties and Health Cross-Nationally: The Contextualizing Role of Familistic Culture and Public Pension Spending in Europe

PubMed Central

2013-01-01

Objectives. Although previous research theorizes that cross-national variation in the relationship between family ties and health is due to nation-level differences in culture and policy/economics, no study has examined this theorization empirically. Method. Using data from the Survey of Health, Ageing, and Retirement in Europe (SHARE) and the Organization for Economic Co-operation and Development (OECD), this study uses multilevel modeling to analyze individual-, nation-, and cross-level effects for 30,291 older adults in 14 nations. Results. Family ties to spouses/partners and parents are associated with better health, but ties to coresident children are associated with poorer health in certain contexts. Familistic culture and public pension spending have a weak but statistically significant moderating effect on the relationship between intergenerational family ties and health. Discussion. This article underscores the complexity of family and highlights the need for continued theorization and measurement at the nation level to promote older adults’ health in diverse contexts. PMID:24043356

Family ties and health cross-nationally: the contextualizing role of familistic culture and public pension spending in Europe.

PubMed

Mair, Christine A

2013-11-01

Although previous research theorizes that cross-national variation in the relationship between family ties and health is due to nation-level differences in culture and policy/economics, no study has examined this theorization empirically. Using data from the Survey of Health, Ageing, and Retirement in Europe (SHARE) and the Organization for Economic Co-operation and Development (OECD), this study uses multilevel modeling to analyze individual-, nation-, and cross-level effects for 30,291 older adults in 14 nations. Family ties to spouses/partners and parents are associated with better health, but ties to coresident children are associated with poorer health in certain contexts. Familistic culture and public pension spending have a weak but statistically significant moderating effect on the relationship between intergenerational family ties and health. This article underscores the complexity of family and highlights the need for continued theorization and measurement at the nation level to promote older adults' health in diverse contexts.

A community of strangers: the dis-embedding of social ties.

PubMed

Parigi, Paolo; State, Bogdan; Dakhlallah, Diana; Corten, Rense; Cook, Karen

2013-01-01

In this paper we explore two contrasting perspectives on individuals' participation in associations. On the one hand, some have considered participation the byproduct of pre-existing friendship ties--the more friends one already has in the association, the more likely he or she is to participate. On the other hand, some have considered participation to be driven by the association's capacity to form new identities--the more new friends one meets in the association, the more likely he or she is to participate. We use detailed temporal data from an online association to adjudicate between these two mechanisms and explore their interplay. Our results show a significant impact of new friendship ties on participation, compared to a negligible impact of pre-existing friends, defined here as ties to other members formed outside of the organization's context. We relate this finding to the sociological literature on participation and we explore its implications in the discussion.

Survey of Quantification and Distance Functions Used for Internet-based Weak-link Sociological Phenomena

DTIC Science & Technology

2013-01-16

linkages, as well as the social strong and weak ties, social cohesion , position and distance. See Appendix II. 8) The co-PI was willing to write it out...Dawn Robinson, A Summary of Sociological Concepts Related to Social Network and Its Techniques for Quantifying Social Cohesion , Social Position, Social Distance, a manuscript, 2013. 3

The Effects of Gendered Social Capital on U.S. Migration: A Comparison of Four Latin American Countries.

PubMed

Côté, Rochelle R; Jensen, Jessica Eva; Roth, Louise Marie; Way, Sandra M

2015-06-01

This article contributes to understandings of gendered social capital by analyzing the effects of gendered ties on the migration of men and women from four Latin American countries (Mexico, Costa Rica, Nicaragua, and the Dominican Republic) to the United States. The research theorizes the importance of strong and weak ties to men and women in each sending country as a product of the gender equity gap in economic participation (low/high) and incidence of female-led families (low/high). The findings reveal that ties to men increase the odds of migration from countries where gender equity and incidence of female-led families are low, while ties to women are more important for migration from countries where gender equity and female-led families are high. Previous research on migration and social capital details the importance of network ties for providing resources and the role of gender in mediating social capital quality and access to network support. Results reveal that not only are different kinds of ties important to female and male migration, but migrants from different countries look to different sources of social capital for assistance.

A Community of Strangers: The Dis-Embedding of Social Ties

PubMed Central

Parigi, Paolo; State, Bogdan; Dakhlallah, Diana; Corten, Rense; Cook, Karen

2013-01-01

In this paper we explore two contrasting perspectives on individuals' participation in associations. On the one hand, some have considered participation the byproduct of pre-existing friendship ties — the more friends one already has in the association, the more likely he or she is to participate. On the other hand, some have considered participation to be driven by the association's capacity to form new identities — the more new friends one meets in the association, the more likely he or she is to participate. We use detailed temporal data from an online association to adjudicate between these two mechanisms and explore their interplay. Our results show a significant impact of new friendship ties on participation, compared to a negligible impact of pre-existing friends, defined here as ties to other members formed outside of the organization's context. We relate this finding to the sociological literature on participation and we explore its implications in the discussion. PMID:23861761

Consequences of Arizona's immigration policy on social capital among Mexican mothers with unauthorized immigration status

PubMed Central

Valdez, Carmen R.; Padilla, Brian; Valentine, Jessa Lewis

2013-01-01

This study explores the consequences of increasingly restrictive immigration policies on social capital among Mexican mothers with unauthorized immigrant status in Arizona. Three focus groups conducted in Arizona explore how mothers’ experiences with immigration policies have affected their neighborhood, community, and family ties. Focus group content and interactions revealed that perceived racial profiling was common among mothers and led to fear of family separation. Several described direct experiences with detention and deportation. Although detention and deportation strengthened social ties between mothers and other unauthorized immigrants, these experiences were detrimental to social ties between mothers and members of the mainstream society, including their children's teachers. Finally, immigration policies were perceived to affect parent-child ties negatively, as mothers reported family stress, financial hardship, and decreased parental availability. PMID:24371370

Changing Views on Intergenerational Ties

PubMed Central

Fingerman, Karen L.; Sechrist, Jori; Birditt, Kira

2015-01-01

Ties to parents or grown children may be the most important social relationships in an adult’s life. Research examining intergenerational relationships has focused on three broader topics: (a) the strength of emotional bonds, (b) exchanges of social support, and (c) the effects of the relationship on individual well-being. This review considers some of the major theoretical developments in the field including solidarity and intergenerational ambivalence theory as well as the newly developed multidimensional model of support. We also consider weaknesses in the research and theories to date and provide suggestions for future research. PMID:23037718

The ties that bind: Ingroup ties are linked with diminished inflammatory immune responses and fewer mental health symptoms through less rumination.

PubMed

Ysseldyk, Renate; McQuaid, Robyn J; McInnis, Opal A; Anisman, Hymie; Matheson, Kimberly

2018-01-01

The present research explored whether components of social identity, namely ingroup ties, affect, and centrality, were differentially linked to mental health and inflammatory immune responses, and whether rumination mediated those relations. Study 1 (N = 138) indicated that stronger ingroup ties were associated with fewer mental health (depressive and post-traumatic stress) symptoms; those relations were mediated by the tendency for individuals with strong ties to rely less on ruminative coping to deal with a stressful life event. Study 2 (N = 54) demonstrated that ingroup ties were negatively associated with depressive symptoms, dispositional rumination, as well as stress-linked inflammatory elements at the physiological level. Consistent associations for centrality and ingroup affect were absent, suggesting that ingroup ties may have unique health benefits.

The ties that bind: Ingroup ties are linked with diminished inflammatory immune responses and fewer mental health symptoms through less rumination

PubMed Central

McQuaid, Robyn J.; McInnis, Opal A.; Anisman, Hymie; Matheson, Kimberly

2018-01-01

The present research explored whether components of social identity, namely ingroup ties, affect, and centrality, were differentially linked to mental health and inflammatory immune responses, and whether rumination mediated those relations. Study 1 (N = 138) indicated that stronger ingroup ties were associated with fewer mental health (depressive and post-traumatic stress) symptoms; those relations were mediated by the tendency for individuals with strong ties to rely less on ruminative coping to deal with a stressful life event. Study 2 (N = 54) demonstrated that ingroup ties were negatively associated with depressive symptoms, dispositional rumination, as well as stress-linked inflammatory elements at the physiological level. Consistent associations for centrality and ingroup affect were absent, suggesting that ingroup ties may have unique health benefits. PMID:29684053

Reducing Electromagnetic Interference in a Grid Tied Single Phase Power Inverter

DTIC Science & Technology

2016-09-01

ELECTROMAGNETIC INTERFERENCE IN A GRID TIED SINGLE PHASE POWER INVERTER by Jason Hassan Valiani September 2016 Thesis Advisor: Giovanna Oriti...3. REPORT TYPE AND DATES COVERED Master’s thesis 4. TITLE AND SUBTITLE REDUCING ELECTROMAGNETIC INTERFERENCE IN A GRID TIED SINGLE PHASE POWER...explored. The primary goal is to understand the effects each modulation strategy has on the conducted electromagnetic interference (EMI) and then

Access, engagement, networks, and norms: Dimensions of social capital at work in a first grade classroom

NASA Astrophysics Data System (ADS)

Wexler-Robock, Stephanie

Social capital refers to access and use of resources available through one's networks to solve problems, and the norms that reflect inclusive or exclusive access to those networks and resources. Research has found positive relationships between social capital, academic achievement, and attainment. Studies, however, have generally examined social capital through factors that occur outside the classroom; students who have social capital, acquired through their family and community relationships, seem to be more successful academically. Limited research has explored what if any factors within the classroom might impact the production, and nature of social capital, or its workings in a classroom. The purpose of this study was to explore the workings and nature of classroom social capital, including its possible relationships to engagement and cognition among 5 student participants. Using methods of qualitative data collection, mixed methods were used to analyze information resources, participants' networking, student work, and classroom discourse. Eight interdependent networking factors and 3 overarching patterns of norms were discovered. The networking factors reflected the structure, content, processes, purposes, and acceptability of participants' networking. The norms, also working interdependently, appeared to promote or inhibit among other things, engagement in networking, help seeking, access, sharing, and intertextual use of diverse, often complex sources of information. Through interaction of the 8 factors and 3 overarching norms, ongoing outcomes of networking appeared to include the creation of bridging (inclusive) and bonding (exclusive) forms of social capital, and depth of scientific conceptual understanding, in this case, about birds. Bridging social capital appeared related to willingness to engage in strong and weak tie networking, help seeking, intertextuality, and possibly to mastery goal orientation for all participants, regardless of reading level. Expository sources more so than narrative texts generated intertextually dense, social and cognitive networks, often between members with weak ties. Together the networking factors and norms shed light on the way discourse, resources, and practice might impact social capital, suggesting that forms of social capital may be produced, accumulated, and depleted by factors and norms that are open to variation and occur within the classroom.

Assessment of the possible contribution of space ties on-board GNSS satellites to the terrestrial reference frame

NASA Astrophysics Data System (ADS)

Bruni, Sara; Rebischung, Paul; Zerbini, Susanna; Altamimi, Zuheir; Errico, Maddalena; Santi, Efisio

2018-04-01

The realization of the international terrestrial reference frame (ITRF) is currently based on the data provided by four space geodetic techniques. The accuracy of the different technique-dependent materializations of the frame physical parameters (origin and scale) varies according to the nature of the relevant observables and to the impact of technique-specific errors. A reliable computation of the ITRF requires combining the different inputs, so that the strengths of each technique can compensate for the weaknesses of the others. This combination, however, can only be performed providing some additional information which allows tying together the independent technique networks. At present, the links used for that purpose are topometric surveys (local/terrestrial ties) available at ITRF sites hosting instruments of different techniques. In principle, a possible alternative could be offered by spacecrafts accommodating the positioning payloads of multiple geodetic techniques realizing their co-location in orbit (space ties). In this paper, the GNSS-SLR space ties on-board GPS and GLONASS satellites are thoroughly examined in the framework of global reference frame computations. The investigation focuses on the quality of the realized physical frame parameters. According to the achieved results, the space ties on-board GNSS satellites cannot, at present, substitute terrestrial ties in the computation of the ITRF. The study is completed by a series of synthetic simulations investigating the impact that substantial improvements in the volume and quality of SLR observations to GNSS satellites would have on the precision of the GNSS frame parameters.

Social support and social interaction ties on internet addiction: integrating online and offline contexts.

PubMed

Wang, Edward Shih-Tse; Wang, Michael Chih-Hung

2013-11-01

This study explores the relationship between social support and social interaction ties on Internet addiction by integrating both online and offline social encounters. A total of 1,642 members of online social communities participated in this research, for which structural equation modeling was used for analysis. The findings show that social support is positively associated with social interaction ties in both online and offline contexts. In addition, online social support and online social interaction ties are positively associated with Internet addiction, whereas offline social support and social interaction ties on Internet addiction are negatively associated. This finding has important implications not only for understanding the cause of Internet addiction but also for understanding the diminishing Internet addiction due to social support and social interaction ties.

Bridging, brokerage and betweenness

PubMed Central

Everett, Martin G.; Valente, Thomas W.

2017-01-01

Valente and Fujimoto (2010) proposed a measure of brokerage in networks based on Granovetter’s classic work on the strength of weak ties. Their paper identified the need for finding node-based measures of brokerage that consider the entire network structure, not just a node’s local environment. The measures they propose, aggregating the average change in cohesion for a node’s links, has several limitations. In this paper we review their method and show how the idea can be modified by using betweenness centrality as an underpinning concept. We explore the properties of the new method and provide point, normalized, and network level variations. This new approach has two advantages, first it provides a more robust means to normalize the measure to control for network size, and second, the modified measure is computationally less demanding making it applicable to larger networks. PMID:28239229

Dyadic Interactions in Service Encounter: Bayesian SEM Approach

NASA Astrophysics Data System (ADS)

Sagan, Adam; Kowalska-Musiał, Magdalena

Dyadic interactions are an important aspects in service encounters. They may be observed in B2B distribution channels, professional services, buying centers, family decision making or WOM communications. The networks consist of dyadic bonds that form dense but weak ties among the actors.

Work-family life courses and markers of stress and inflammation in mid-life: evidence from the National Child Development Study

PubMed Central

Lacey, Rebecca E; Sacker, Amanda; Kumari, Meena; Worts, Diana; McDonough, Peggy; Booker, Cara; McMunn, Anne

2016-01-01

Abstract Background: This study investigated associations between work-family life courses and biomarkers of inflammation and stress in mid-life among British men and women. Gender differences in these associations were also explored. Methods: A novel statistical method—multi-channel sequence analysis—defined work-family life courses between the ages of 16 and 42 years, combining annual information on work, partnership and parenthood. Associations between work-family life courses and inflammation [C-reactive protein (CRP), fibrinogen and von Willebrand factor] and cortisol at age 44/45 years were tested using multivariate linear regression using multiply-imputed data on almost 6500 participants from the National Child Development Study 1958 British birth cohort. Results: Compared with those who combined strong ties to paid work with later transitions to stable family lives (‘Work, later family’ group), ‘Teen parents’ had higher CRP [40.6% higher, 95% confidence interval (CI): 5.6, 87.0] and fibrinogen (7.8% higher, 95% CI: 2.3, 13.5) levels, and homemakers (‘No paid work, early family’) had raised fibrinogen levels (4.7% higher, 95% CI: 0.7, 9.0), independent of childhood health and socioeconomic position, adult socioeconomic position, health behaviours and body mass index (BMI). Those who combined later transitions to stable family ties with a career break for childrearing had higher post-waking cortisol than the ‘Work, later family’ group; however, no associations were seen for other work-family types, therefore suggesting a null finding with cortisol. No statistically significant gender interactions in associations between work-family types and inflammatory or cortisol outcomes were found. Conclusions: Work-family life courses characterised by early parenthood or weak work ties were associated with a raised risk profile in relation to chronic inflammation. PMID:26467761

Error assessment of local tie vectors in space geodesy

NASA Astrophysics Data System (ADS)

Falkenberg, Jana; Heinkelmann, Robert; Schuh, Harald

2014-05-01

For the computation of the ITRF, the data of the geometric space-geodetic techniques on co-location sites are combined. The combination increases the redundancy and offers the possibility to utilize the strengths of each technique while mitigating their weaknesses. To enable the combination of co-located techniques each technique needs to have a well-defined geometric reference point. The linking of the geometric reference points enables the combination of the technique-specific coordinate to a multi-technique site coordinate. The vectors between these reference points are called "local ties". The realization of local ties is usually reached by local surveys of the distances and or angles between the reference points. Identified temporal variations of the reference points are considered in the local tie determination only indirectly by assuming a mean position. Finally, the local ties measured in the local surveying network are to be transformed into the ITRF, the global geocentric equatorial coordinate system of the space-geodetic techniques. The current IERS procedure for the combination of the space-geodetic techniques includes the local tie vectors with an error floor of three millimeters plus a distance dependent component. This error floor, however, significantly underestimates the real accuracy of local tie determination. To fullfill the GGOS goals of 1 mm position and 0.1 mm/yr velocity accuracy, an accuracy of the local tie will be mandatory at the sub-mm level, which is currently not achievable. To assess the local tie effects on ITRF computations, investigations of the error sources will be done to realistically assess and consider them. Hence, a reasonable estimate of all the included errors of the various local ties is needed. An appropriate estimate could also improve the separation of local tie error and technique-specific error contributions to uncertainties and thus access the accuracy of space-geodetic techniques. Our investigations concern the simulation of the error contribution of each component of the local tie definition and determination. A closer look into the models of reference point definition, of accessibility, of measurement, and of transformation is necessary to properly model the error of the local tie. The effect of temporal variations on the local ties will be studied as well. The transformation of the local survey into the ITRF can be assumed to be the largest error contributor, in particular the orientation of the local surveying network to the ITRF.

Driving magnetic turbulence using flux ropes in a moderate guide field linear system

NASA Astrophysics Data System (ADS)

Brookhart, Matthew I.; Stemo, Aaron; Waleffe, Roger; Forest, Cary B.

2017-12-01

We present a series of experiments on novel, line-tied plasma geometries as a study of the generation of chaos and turbulence in line-tied systems. Plasma production and the injection scale for magnetic energy is provided by spatially discrete plasma guns that inject both plasma and current. The guns represent a technique for controlling the injection scale of magnetic energy. A two-dimensional (2-D) array of magnetic probes provides spatially resolved time histories of the magnetic fluctuations at a single cross-section of the experimental cylinder, allowing simultaneous spatial measurements of chaotic and turbulent behaviour. The first experiment shows chaotic fluctuations and self-organization in a hollow-current line-tied screw pinch. These dynamics is modulated primarily by the applied magnetic field and weakly by the plasma current and safety factor. The second experiment analyses the interactions of multiple line-tied flux ropes. The flux ropes all exhibit chaotic behaviour, and under certain conditions develop an inverse cascade to larger scales and a turbulent inertial range with magnetic energy ( ) related to perpendicular wave number ( \\bot $ ) as \\bot -2.5\\pm 0.5$ .

Acculturation Versus Cultural Retention: The Interactive Impact of Acculturation and Co-ethnic Ties on Substance Use Among Chinese Students in the United States.

PubMed

Yang, Xiaozhao Yousef; Yang, Fenggang

2018-06-01

Acculturation is often found to increase substance use among immigrants in the U.S., but such effect may depend on how immigrants are attached to their co-ethnic community. Meanwhile, the high socioeconomic status of some new immigrant groups also challenges the classical assumption that ties to co-ethnic community are associated with deviance. With a sample (n = 960) collected from a population of Chinese students in a large public university in the U.S., we tested how do the interplays between acculturation and co-ethnic ties affect substance use. This study establishes that: (1) different dimensions of acculturation have opposite effects on substance use; (2) acculturative stress does not explain the association between acculturation and substance use; (3) acculturation increases the likelihood of substance use only when one has weak attachment to their co-ethnic community. The findings are consistent for three dependent variables: smoking, drinking, and drunkenness, and for the different constructs of acculturation and co-ethnic ties. Ties to co-ethnic community may provide important social support for immigrants, while acculturation may alleviate the insular subculture that promotes at-risk behaviors. We encourage policy makers to consider the cooperative nature of acculturation and cultural retention for the improvement of health among this growing population.

The weakness of family ties and their perpetuating effects on gender violence: a qualitative study in Mexico.

PubMed

Agoff, Carolina; Herrera, Cristina; Castro, Roberto

2007-11-01

Research into intimate partner violence has shown that social isolation constitutes a risk factor, and the presence of social networks can be an important source of social support. This research note presents some results of an empirical study carried out in Mexico into women's social relations, especially their family relations, and their role in the promotion of traditional gender norms. Findings indicate that some of the main conditions that are associated with the production of violence against women are either generated or reinforced within the realm of what can be regarded as women's "strong ties."

Raman spectra of adsorbed layers on space shuttle and AOTV thermal protection system surface

NASA Technical Reports Server (NTRS)

Willey, Ronald J.

1987-01-01

Surfaces of interest to space vehicle heat shield design were struck by a 2 W argon ion laser line while subjected to supersonic arc jet flow conditions. Emission spectra were taken at 90 deg to the angle of laser incidence on the test object. Results showed possible weak Raman shifts which could not be directly tied to any particular parameter such as surface temperature or gas composition. The investigation must be considered exploratory in terms of findings. Many undesirable effects were found and corrected as the project progressed. For instance, initial spectra settings led to ghosts which were eliminated by closing the intermediate of filter slit of the Spex from 8 to 3 mm. Further, under certain conditions, plasma lines from the laser were observed. Several materials were also investigated at room temperature for Raman shifts. Results showed Raman shifts for RCC and TEOS coated materials. The HRSI materials showed only weak Raman shifts, however, substantial efforts were made in studying these materials. Baseline materials showed the technique to be sound. The original goal was to find a Raman shift for the High-temperature Reusable Surface Insulation (HRSI) Reaction Cured borosilicate Glass (RCG) coated material and tie the amplitude of this peak to Arc jet conditions. Weak Raman shifts may be present, however, time limitations prevented confirmation.

Indigeneity and Homeland: Land, History, Ceremony, and Language

ERIC Educational Resources Information Center

Lerma, Michael

2012-01-01

What is the relationship between Indigenous peoples and violent reactions to contemporary states? This research explores differing, culturally informed notions of attachment to land or place territory. Mechanistic ties and organic ties to land are linked to a key distinction between Indigenous peoples and non-Indigenous peoples. Utilizing the…

Models for financing the regulation of pharmaceutical promotion.

PubMed

Lexchin, Joel

2012-07-11

Pharmaceutical companies spend huge sums promoting their products whereas regulation of promotional activities is typically underfinanced. Any option for financing the monitoring and regulation of promotion should adhere to three basic principles: stability, predictability and lack of (perverse) ties between the level of financing and performance. This paper explores the strengths and weaknesses of six different models. All these six models considered here have positive and negative features and none may necessarily be ideal in any particular country. Different countries may choose to utilize a combination of two or more of these models in order to raise sufficient revenue. Financing of regulation of drug promotion should more than pay for itself through the prevention of unnecessary drug costs and the avoidance of adverse health effects due to inappropriate prescribing. However, it involves an initial outlay of money that is currently not being spent and many national governments, in both rich and poor countries, are unwilling to incur extra costs.

Social bonds and internet pornographic exposure among adolescents.

PubMed

Mesch, Gustavo S

2009-06-01

Concern has grown regarding possible harm to the social and psychological development of children and adolescents exposed to Internet pornography. Parents, academics and researchers have documented pornography from the supply side, assuming that its availability explains consumption satisfactorily. The current paper explored the user's dimension, probing whether pornography consumers differed from other Internet users, as well as the social characteristics of adolescent frequent pornography consumers. Data from a 2004 survey of a national representative sample of the adolescent population in Israel were used (n=998). Adolescent frequent users of the Internet for pornography were found to differ in many social characteristics from the group that used the Internet for information, social communication and entertainment. Weak ties to mainstream social institutions were characteristic of the former group but not of the latter. X-rated material consumers proved to be a distinct sub-group at risk of deviant behaviour.

Coexpression of Ang1 and Tie2 in Odontoblasts of Mouse Developing and Mature Teeth—A New Insight into Dentinogenesis

PubMed Central

Nakajima, Kazunori; Shibata, Yasuaki; Hishikawa, Yoshitaka; Suematsu, Takashi; Mori, Masako; Fukuhara, Shigetomo; Koji, Takehiko; Sawase, Takashi; Ikeda, Tohru

2014-01-01

Angiopoietin-1 regulates vascular angiogenesis and stabilization, and is reported to promote bone formation by facilitating angiogenesis. To estimate the role of Ang1 in odontogenesis, we explored the distribution of Ang1 and the receptor, Tie2 in the mouse developing and mature first molar of the mandible. At embryonic day 18, when differentiation of odontoblasts begins, immunosignals for Ang1 were intensely detected in the basement membrane and the distal side, which faced the basement membrane of odontoblasts. In situ hybridization revealed that Ang1 was expressed in odontoblasts and ameloblasts facing the basement membrane. Tie2 was localized in the distal side of odontoblasts. After birth, Ang1 was detected in the predentin, whereas both Ang1 and Tie2 were colocalized in odontoblasts and odontoblast processes. These distributions were retained up to 8 weeks. In contrast to odontoblasts, ameloblasts, cementoblasts and osteoblasts expressed Ang1 but did not express Tie2. Colocalization of Ang1 and Tie2 in odontoblasts and selective expression of Tie2 in odontoblasts among cells responsible for calcified tissue formation suggested the involvement of autocrine signals of Ang1-Tie2 in dentinogenesis. PMID:24761046

Social Network Type and Long-Term Condition Management Support: A Cross-Sectional Study in Six European Countries.

PubMed

Vassilev, Ivaylo; Rogers, Anne; Kennedy, Anne; Wensing, Michel; Koetsenruijter, Jan; Orlando, Rosanna; Portillo, Maria Carmen; Culliford, David

2016-01-01

Network types and characteristics have been linked to the capacity of inter-personal environments to mobilise and share resources. The aim of this paper is to examine personal network types in relation to long-term condition management in order to identify the properties of network types most likely to provide support for those with a long-term condition. A cross-sectional observational survey of people with type 2 diabetes using interviews and questionnaires was conducted between April and October 2013 in six European countries: Greece, Spain, Bulgaria, Norway, United Kingdom, and Netherlands. 1862 people with predominantly lower socio-economic status were recruited from each country. We used k-means clustering analysis to derive the network types, and one-way analysis of variance and multivariate logistic regression analysis to explore the relationship between network type socio-economic characteristics, self-management monitoring and skills, well-being, and network member work. Five network types of people with long-term conditions were identified: restricted, minimal family, family, weak ties, and diverse. Restricted network types represented those with the poorest self-management skills and were associated with limited support from social network members. Restricted networks were associated with poor indicators across self-management capacity, network support, and well-being. Diverse networks were associated with more enhanced self-management skills amongst those with a long-term condition and high level of emotional support. It was the three network types which had a large number of network members (diverse, weak ties, and family) where healthcare utilisation was most likely to correspond to existing health needs. Our findings suggest that type of increased social involvement is linked to greater self-management capacity and potentially lower formal health care costs indicating that diverse networks constitute the optimal network type as a policy in terms of the design of LTCM interventions and building support for people with LTCs.

Credit Squeeze Exposes Weaknesses in Investments

ERIC Educational Resources Information Center

Blumenstyk, Goldie; Field, Kelly

2008-01-01

This article reports that the credit crisis tying global financing systems into knots has left hundreds of colleges scrambling for cash to pay their bills and to cover the spiking interest on their debts. While it is still unclear to what extent the federal government's new $700-billion bailout package will help unwind the credit tangle, the…

Whose Evidence Is It Anyway?

ERIC Educational Resources Information Center

Gorard, Stephen

2008-01-01

When governments and pressure groups attend only to research that suits their political purposes, it makes a mockery of the idea of evidence-informed policy and practice. In this article, the author cites examples of research that picked up weak and misleading evidence for political purposes. The author argues that researchers are tied in to the…

Teaching to the Tails: Teacher Performance Pay and the Distribution of Student Achievement

ERIC Educational Resources Information Center

Loyalka, Prashant; Sylvia, Sean; Liu, Chengfang; Chu, James; Rozelle, Scott

2015-01-01

Growing evidence suggests that teachers in developing countries often have weak or misaligned incentives for improving student outcomes. In response, policymakers and researchers have proposed performance pay as a way to improve student outcomes by tying concrete measures like achievement scores to teacher pay. While evidence from randomized…

Associations Between Long-Term Gang Membership and Informal Social Control Processes, Drug Use, and Delinquent Behavior Among Mexican American Youth

PubMed Central

Cepeda, Alice; Saint Onge, Jarron M.; Nowotny, Kathryn M.; Valdez, Avelardo

2018-01-01

Research has found that among juveniles weak ties to informal social control entities such as parents, school, and conventional peers increase the probability of the initiation and continuation of deviant behaviors such as drug use and crime. Given the weak ties of formal social control mechanisms in highly disadvantaged communities, informal social control mechanisms are often an important deterrent that reduce or moderate engagement in deviant behaviors among serious and persistent offenders. This analysis examines the association between long-term gang membership and adolescent informal social control processes, drug use, and delinquency. This research is based on data from a study of 160 Mexican American male gang members between the ages of 16 and 20. Findings suggest that among gang members in this context, commonly studied informal control mechanisms such as the family and schools do not function to deter long-term gang membership that is associated with serious criminal and violent behavior and drug use. The implications for future research on desistance or continuation of antisocial behavior across the life course are discussed. PMID:25979430

Disseminating educational innovations in health care practice: training versus social networks.

PubMed

Jippes, Erik; Achterkamp, Marjolein C; Brand, Paul L P; Kiewiet, Derk Jan; Pols, Jan; van Engelen, Jo M L

2010-05-01

Improvements and innovation in health service organization and delivery have become more and more important due to the gap between knowledge and practice, rising costs, medical errors, and the organization of health care systems. Since training and education is widely used to convey and distribute innovative initiatives, we examined the effect that following an intensive Teach-the-Teacher training had on the dissemination of a new structured competency-based feedback technique of assessing clinical competencies among medical specialists in the Netherlands. We compared this with the effect of the structure of the social network of medical specialists, specifically the network tie strength (strong ties versus weak ties). We measured dissemination of the feedback technique by using a questionnaire filled in by Obstetrics & Gynecology and Pediatrics residents (n=63). Data on network tie strength was gathered with a structured questionnaire given to medical specialists (n=81). Social network analysis was used to compose the required network coefficients. We found a strong effect for network tie strength and no effect for the Teach-the-Teacher training course on the dissemination of the new structured feedback technique. This paper shows the potential that social networks have for disseminating innovations in health service delivery and organization. Further research is needed into the role and structure of social networks on the diffusion of innovations between departments and the various types of innovations involved. Copyright (c) 2010 Elsevier Ltd. All rights reserved.

Consume, Modify, Share (CMS): The Interplay between Individual Decisions and Structural Network Properties in the Diffusion of Information

PubMed Central

Koren, Hila; Kaminer, Ido

2016-01-01

Widely used information diffusion models such as Independent Cascade Model, Susceptible Infected Recovered (SIR) and others fail to acknowledge that information is constantly subject to modification. Some aspects of information diffusion are best explained by network structural characteristics while in some cases strong influence comes from individual decisions. We introduce reinvention, the ability to modify information, as an individual level decision that affects the diffusion process as a whole. Based on a combination of constructs from the Diffusion of Innovations and the Critical Mass Theories, the present study advances the CMS (consume, modify, share) model which accounts for the interplay between network structure and human behavior and interactions. The model's building blocks include processes leading up to and following the formation of a critical mass of information adopters and disseminators. We examine the formation of an inflection point, information reach, sustainability of the diffusion process and collective value creation. The CMS model is tested on two directed networks and one undirected network, assuming weak or strong ties and applying constant and relative modification schemes. While all three networks are designed for disseminating new knowledge they differ in structural properties. Our findings suggest that modification enhances the diffusion of information in networks that support undirected connections and carries the biggest effect when information is shared via weak ties. Rogers' diffusion model and traditional information contagion models are fine tuned. Our results show that modifications not only contribute to a sustainable diffusion process, but also aid information in reaching remote areas of the network. The results point to the importance of cultivating weak ties, allowing reciprocal interaction among nodes and supporting the modification of information in promoting diffusion processes. These results have theoretical and practical implications for designing networks aimed at accelerating the creation and diffusion of information. PMID:27798636

Consume, Modify, Share (CMS): The Interplay between Individual Decisions and Structural Network Properties in the Diffusion of Information.

PubMed

Koren, Hila; Kaminer, Ido; Raban, Daphne Ruth

2016-01-01

Widely used information diffusion models such as Independent Cascade Model, Susceptible Infected Recovered (SIR) and others fail to acknowledge that information is constantly subject to modification. Some aspects of information diffusion are best explained by network structural characteristics while in some cases strong influence comes from individual decisions. We introduce reinvention, the ability to modify information, as an individual level decision that affects the diffusion process as a whole. Based on a combination of constructs from the Diffusion of Innovations and the Critical Mass Theories, the present study advances the CMS (consume, modify, share) model which accounts for the interplay between network structure and human behavior and interactions. The model's building blocks include processes leading up to and following the formation of a critical mass of information adopters and disseminators. We examine the formation of an inflection point, information reach, sustainability of the diffusion process and collective value creation. The CMS model is tested on two directed networks and one undirected network, assuming weak or strong ties and applying constant and relative modification schemes. While all three networks are designed for disseminating new knowledge they differ in structural properties. Our findings suggest that modification enhances the diffusion of information in networks that support undirected connections and carries the biggest effect when information is shared via weak ties. Rogers' diffusion model and traditional information contagion models are fine tuned. Our results show that modifications not only contribute to a sustainable diffusion process, but also aid information in reaching remote areas of the network. The results point to the importance of cultivating weak ties, allowing reciprocal interaction among nodes and supporting the modification of information in promoting diffusion processes. These results have theoretical and practical implications for designing networks aimed at accelerating the creation and diffusion of information.

A Multirelational Social Network Analysis of an Online Health Community for Smoking Cessation.

PubMed

Zhao, Kang; Wang, Xi; Cha, Sarah; Cohn, Amy M; Papandonatos, George D; Amato, Michael S; Pearson, Jennifer L; Graham, Amanda L

2016-08-25

Online health communities (OHCs) provide a convenient and commonly used way for people to connect around shared health experiences, exchange information, and receive social support. Users often interact with peers via multiple communication methods, forming a multirelational social network. Use of OHCs is common among smokers, but to date, there have been no studies on users' online interactions via different means of online communications and how such interactions are related to smoking cessation. Such information can be retrieved in multirelational social networks and could be useful in the design and management of OHCs. To examine the social network structure of an OHC for smoking cessation using a multirelational approach, and to explore links between subnetwork position (ie, centrality) and smoking abstinence. We used NetworkX to construct 4 subnetworks based on users' interactions via blogs, group discussions, message boards, and private messages. We illustrated topological properties of each subnetwork, including its degree distribution, density, and connectedness, and compared similarities among these subnetworks by correlating node centrality and measuring edge overlap. We also investigated coevolution dynamics of this multirelational network by analyzing tie formation sequences across subnetworks. In a subset of users who participated in a randomized, smoking cessation treatment trial, we conducted user profiling based on users' centralities in the 4 subnetworks and identified user groups using clustering techniques. We further examined 30-day smoking abstinence at 3 months postenrollment in relation to users' centralities in the 4 subnetworks. The 4 subnetworks have different topological characteristics, with message board having the most nodes (36,536) and group discussion having the highest network density (4.35×10(-3)). Blog and message board subnetworks had the most similar structures with an in-degree correlation of .45, out-degree correlation of .55, and Jaccard coefficient of .23 for edge overlap. A new tie in the group discussion subnetwork had the lowest probability of triggering subsequent ties among the same two users in other subnetworks: 6.33% (54,142/855,893) for 2-tie sequences and 2.13% (18,207/855,893) for 3-tie sequences. Users' centralities varied across the 4 subnetworks. Among a subset of users enrolled in a randomized trial, those with higher centralities across subnetworks generally had higher abstinence rates, although high centrality in the group discussion subnetwork was not associated with higher abstinence rates. A multirelational approach revealed insights that could not be obtained by analyzing the aggregated network alone, such as the ineffectiveness of group discussions in triggering social ties of other types, the advantage of blogs, message boards, and private messages in leading to subsequent social ties of other types, and the weak connection between one's centrality in the group discussion subnetwork and smoking abstinence. These insights have implications for the design and management of online social networks for smoking cessation.

A Multirelational Social Network Analysis of an Online Health Community for Smoking Cessation

PubMed Central

Wang, Xi; Cha, Sarah; Cohn, Amy M; Papandonatos, George D; Amato, Michael S; Pearson, Jennifer L; Graham, Amanda L

2016-01-01

Background Online health communities (OHCs) provide a convenient and commonly used way for people to connect around shared health experiences, exchange information, and receive social support. Users often interact with peers via multiple communication methods, forming a multirelational social network. Use of OHCs is common among smokers, but to date, there have been no studies on users’ online interactions via different means of online communications and how such interactions are related to smoking cessation. Such information can be retrieved in multirelational social networks and could be useful in the design and management of OHCs. Objective To examine the social network structure of an OHC for smoking cessation using a multirelational approach, and to explore links between subnetwork position (ie, centrality) and smoking abstinence. Methods We used NetworkX to construct 4 subnetworks based on users’ interactions via blogs, group discussions, message boards, and private messages. We illustrated topological properties of each subnetwork, including its degree distribution, density, and connectedness, and compared similarities among these subnetworks by correlating node centrality and measuring edge overlap. We also investigated coevolution dynamics of this multirelational network by analyzing tie formation sequences across subnetworks. In a subset of users who participated in a randomized, smoking cessation treatment trial, we conducted user profiling based on users’ centralities in the 4 subnetworks and identified user groups using clustering techniques. We further examined 30-day smoking abstinence at 3 months postenrollment in relation to users’ centralities in the 4 subnetworks. Results The 4 subnetworks have different topological characteristics, with message board having the most nodes (36,536) and group discussion having the highest network density (4.35×10−3). Blog and message board subnetworks had the most similar structures with an in-degree correlation of .45, out-degree correlation of .55, and Jaccard coefficient of .23 for edge overlap. A new tie in the group discussion subnetwork had the lowest probability of triggering subsequent ties among the same two users in other subnetworks: 6.33% (54,142/855,893) for 2-tie sequences and 2.13% (18,207/855,893) for 3-tie sequences. Users’ centralities varied across the 4 subnetworks. Among a subset of users enrolled in a randomized trial, those with higher centralities across subnetworks generally had higher abstinence rates, although high centrality in the group discussion subnetwork was not associated with higher abstinence rates. Conclusions A multirelational approach revealed insights that could not be obtained by analyzing the aggregated network alone, such as the ineffectiveness of group discussions in triggering social ties of other types, the advantage of blogs, message boards, and private messages in leading to subsequent social ties of other types, and the weak connection between one’s centrality in the group discussion subnetwork and smoking abstinence. These insights have implications for the design and management of online social networks for smoking cessation. PMID:27562640

Children in Residential Group Care with No Family Ties: Facing Existential Aloneness

ERIC Educational Resources Information Center

Dvir, Orly; Weiner, Anita; Kupermintz, Hagai

2012-01-01

The issue of children living in residential group care in Israel completely without family ties is studied in order to explore the feelings of staff and uncover possible characteristics of these children. Data were collected through focus groups, questionnaires, and life stories of children who left group care at 18 years of age. Results reveal…

Impact of Cross-Tie Properties on the Modal Behavior of Cable Networks on Cable-Stayed Bridges

PubMed Central

Ahmad, Javaid; Ghrib, Faouzi

2015-01-01

Dynamic behaviour of cable networks is highly dependent on the installation location, stiffness, and damping of cross-ties. Thus, these are the important design parameters for a cable network. While the effects of the former two on the network response have been investigated to some extent in the past, the impact of cross-tie damping has rarely been addressed. To comprehend our knowledge of mechanics associated with cable networks, in the current study, an analytical model of a cable network will be proposed by taking into account both cross-tie stiffness and damping. In addition, the damping property of main cables in the network will also be considered in the formulation. This would allow exploring not only the effectiveness of a cross-tie design on enhancing the in-plane stiffness of a constituted cable network, but also its energy dissipation capacity. The proposed analytical model will be applied to networks with different configurations. The influence of cross-tie stiffness and damping on the modal response of various types of networks will be investigated by using the corresponding undamped rigid cross-tie network as a reference base. Results will provide valuable information on the selection of cross-tie properties to achieve more effective cable vibration control. PMID:26167539

Impact of Cross-Tie Properties on the Modal Behavior of Cable Networks on Cable-Stayed Bridges.

PubMed

Ahmad, Javaid; Cheng, Shaohong; Ghrib, Faouzi

2015-01-01

Dynamic behaviour of cable networks is highly dependent on the installation location, stiffness, and damping of cross-ties. Thus, these are the important design parameters for a cable network. While the effects of the former two on the network response have been investigated to some extent in the past, the impact of cross-tie damping has rarely been addressed. To comprehend our knowledge of mechanics associated with cable networks, in the current study, an analytical model of a cable network will be proposed by taking into account both cross-tie stiffness and damping. In addition, the damping property of main cables in the network will also be considered in the formulation. This would allow exploring not only the effectiveness of a cross-tie design on enhancing the in-plane stiffness of a constituted cable network, but also its energy dissipation capacity. The proposed analytical model will be applied to networks with different configurations. The influence of cross-tie stiffness and damping on the modal response of various types of networks will be investigated by using the corresponding undamped rigid cross-tie network as a reference base. Results will provide valuable information on the selection of cross-tie properties to achieve more effective cable vibration control.

How Do Communities Act? Unique Events and Purposeful Strategies in the Formation of an Industrial Base in Rivertown. [Revised].

ERIC Educational Resources Information Center

Brown, Ralph B.

Effective rural education depends on active community involvement. This ethnographic case study examines three models of community organization as an explanation of how community action occurs. The three models are: (1) individuals interacting in formal and informal groups; (2) networks of "weak ties" effective for diffusing information and…

ERT and Well Data Tie for Nickel Laterite Characterization

NASA Astrophysics Data System (ADS)

Aswad, Sabrianto; Mamela Mais, Difar; Syamsuddin; Wanni

2018-03-01

The need of ERT method in nickel latentes exploration can’t be deny. This method have capability to make exploration more effective and efficient. In reality this method still remain ambiguity in its application, especially for geologist and mining expert. These ambiguity related with layer zone determination (limonite, saprolite and bedrock), the same resistivity values in the different zones and determination of bedrock. This paper try to expose interesting fact to overcome this ambiguity by using ERT data and drill data tie. This tie will show characteristic of nickel lateric based on resisitivity value and the contribution of chemistry element for resistivity value. Data ERT was collected by using gradient configuration and well data consist of mayor element and minor element. Tie result showed difference resistivity value in limonite layer influence by Fe, H2O and Ni, where resistivity value from saprolite layer influenced by Fe, H2O, Si02, MgO, Al, Cr, and Ni in certain accumulation. In bedrock layer, almost all drill data did not reach bedrock but only reached the boulder alone, it is supported by the value of the resistivity of rock unserpentinized peridotite which should show a relatively large resistivity value

Skeleton of weighted social network

NASA Astrophysics Data System (ADS)

Zhang, X.; Zhu, J.

2013-03-01

In the literature of social networks, understanding topological structure is an important scientific issue. In this paper, we construct a network from mobile phone call records and use the cumulative number of calls as a measure of the weight of a social tie. We extract skeletons from the weighted social network on the basis of the weights of ties, and we study their properties. We find that strong ties can support the skeleton in the network by studying the percolation characters. We explore the centrality of w-skeletons based on the correlation between some centrality measures and the skeleton index w of a vertex, and we find that the average centrality of a w-skeleton increases as w increases. We also study the cumulative degree distribution of the successive w-skeletons and find that as w increases, the w-skeleton tends to become more self-similar. Furthermore, fractal characteristics appear in higher w-skeletons. We also explore the global information diffusion efficiency of w-skeletons using simulations, from which we can see that the ties in the high w-skeletons play important roles in information diffusion. Identifying such a simple structure of a w-skeleton is a step forward toward understanding and representing the topological structure of weighted social networks.

More Stable Ties or Better Structure? An Examination of the Impact of Co-author Network on Team Knowledge Creation

PubMed Central

Li, Mingze; Zhuang, Xiaoli; Liu, Wenxing; Zhang, Pengcheng

2017-01-01

This study aims to explore the influence of co-author network on team knowledge creation. Integrating the two traditional perspectives of network relationship and network structure, we examine the direct and interactive effects of tie stability and structural holes on team knowledge creation. Tracking scientific articles published by 111 scholars in the research field of human resource management from the top 8 American universities, we analyze scholars’ scientific co-author networks. The result indicates that tie stability changes the teams’ information processing modes and, when graphed, results in an inverted U-shape relationship between tie stability and team knowledge creation. Moreover, structural holes in co-author network are proved to be harmful to team knowledge sharing and diffusion, thereby impeding team knowledge creation. Also, tie stability and structural hole interactively influence team knowledge creation. When the number of structural hole is low in the co-author network, the graphical representation of the relationship between tie stability and team knowledge creation tends to be a more distinct U-shape. PMID:28993744

More Stable Ties or Better Structure? An Examination of the Impact of Co-author Network on Team Knowledge Creation.

PubMed

Li, Mingze; Zhuang, Xiaoli; Liu, Wenxing; Zhang, Pengcheng

2017-01-01

This study aims to explore the influence of co-author network on team knowledge creation. Integrating the two traditional perspectives of network relationship and network structure, we examine the direct and interactive effects of tie stability and structural holes on team knowledge creation. Tracking scientific articles published by 111 scholars in the research field of human resource management from the top 8 American universities, we analyze scholars' scientific co-author networks. The result indicates that tie stability changes the teams' information processing modes and, when graphed, results in an inverted U-shape relationship between tie stability and team knowledge creation. Moreover, structural holes in co-author network are proved to be harmful to team knowledge sharing and diffusion, thereby impeding team knowledge creation. Also, tie stability and structural hole interactively influence team knowledge creation. When the number of structural hole is low in the co-author network, the graphical representation of the relationship between tie stability and team knowledge creation tends to be a more distinct U-shape.

Work-family life courses and markers of stress and inflammation in mid-life: evidence from the National Child Development Study.

PubMed

Lacey, Rebecca E; Sacker, Amanda; Kumari, Meena; Worts, Diana; McDonough, Peggy; Booker, Cara; McMunn, Anne

2016-08-01

This study investigated associations between work-family life courses and biomarkers of inflammation and stress in mid-life among British men and women. Gender differences in these associations were also explored. A novel statistical method-multi-channel sequence analysis-defined work-family life courses between the ages of 16 and 42 years, combining annual information on work, partnership and parenthood. Associations between work-family life courses and inflammation [C-reactive protein (CRP), fibrinogen and von Willebrand factor] and cortisol at age 44/45 years were tested using multivariate linear regression using multiply-imputed data on almost 6500 participants from the National Child Development Study 1958 British birth cohort. Compared with those who combined strong ties to paid work with later transitions to stable family lives ('Work, later family' group), 'Teen parents' had higher CRP [40.6% higher, 95% confidence interval (CI): 5.6, 87.0] and fibrinogen (7.8% higher, 95% CI: 2.3, 13.5) levels, and homemakers ('No paid work, early family') had raised fibrinogen levels (4.7% higher, 95% CI: 0.7, 9.0), independent of childhood health and socioeconomic position, adult socioeconomic position, health behaviours and body mass index (BMI). Those who combined later transitions to stable family ties with a career break for childrearing had higher post-waking cortisol than the 'Work, later family' group; however, no associations were seen for other work-family types, therefore suggesting a null finding with cortisol. No statistically significant gender interactions in associations between work-family types and inflammatory or cortisol outcomes were found. Work-family life courses characterised by early parenthood or weak work ties were associated with a raised risk profile in relation to chronic inflammation. © The Author 2015. Published by Oxford University Press on behalf of the International Epidemiological Association.

Root strength changes after logging in southeast Alaska

Treesearch

R. R. Ziemer; D. N. Swanston

1977-01-01

Abstract - A crucial factor in the stability of steep forested slopes is the role of plant roots in maintaining the shear strength of soil mantles. Roots add strength to the soil by vertically anchoring through the soil mass into failures in the bedrock and by laterally tying the slope together across zones of weakness or instability. Once the covering vegetation is...

Models for financing the regulation of pharmaceutical promotion

PubMed Central

2012-01-01

Pharmaceutical companies spend huge sums promoting their products whereas regulation of promotional activities is typically underfinanced. Any option for financing the monitoring and regulation of promotion should adhere to three basic principles: stability, predictability and lack of (perverse) ties between the level of financing and performance. This paper explores the strengths and weaknesses of six different models. All these six models considered here have positive and negative features and none may necessarily be ideal in any particular country. Different countries may choose to utilize a combination of two or more of these models in order to raise sufficient revenue. Financing of regulation of drug promotion should more than pay for itself through the prevention of unnecessary drug costs and the avoidance of adverse health effects due to inappropriate prescribing. However, it involves an initial outlay of money that is currently not being spent and many national governments, in both rich and poor countries, are unwilling to incur extra costs. PMID:22784944

Peer influence processes for youth delinquency and depression.

PubMed

Reynolds, Andrew D; Crea, Thomas M

2015-08-01

This study explores the multiple factors that account for peer influence processes of adolescent delinquency and depression using data from Waves I and II of the National Longitudinal Study of Adolescent to Adult Health (Add Health). Random-effects longitudinal negative binomial models were used to predict depression and delinquency, controlling for social connection variables to account for selection bias. Findings suggest peer depression and delinquency are both predictive of youth delinquency, while peer influences of depression are much more modest. Youth who are more connected to parents and communities and who are more popular within their networks are more susceptible to peer influence, while self-regulating youth are less susceptible. We find support for theories of popularity-socialization as well as weak-ties in explaining social network factors that amplify or constrain peer influence. We argue that practitioners working with youth should consider network-informed interventions to improve program efficacy and avoid iatrogenic effects. Copyright © 2015 The Foundation for Professionals in Services for Adolescents. Published by Elsevier Ltd. All rights reserved.

Microgravity effects on fine motor skills: tying surgical knots during parabolic flight.

PubMed

Rafiq, Azhar; Hummel, Russ; Lavrentyev, Vladimir; Derry, William; Williams, David; Merrell, Ronald C

2006-08-01

The health provider on a space exploration mission cannot evacuate a patient to Earth. Contingency plans for medical intervention must be designed for autonomy. This study measured the effect of microgravity on performance of fine motor skills such as basic surgical tasks. Eight subjects, six with medical and two with non-medical backgrounds, were evaluated during parabolic microgravity flights aboard NASA's KC-135. We evaluated their skill in tying surgical knots on simulated skin made of silicone using standard techniques for minimally invasive surgery. LabView software was developed to archive forces applied to the laparoscopic tool handles during knot-tying. Studies were controlled for medication (ScopeDex) and the aircraft environment. All participants completed the tests successfully. The data indicated that increased force was applied to the instruments and knot quality decreased during flight compared with ground control sessions. Specific metrics of surgical task performance are essential in developing education modules for providers of medical care during exploration-class missions.

Community Detection in Signed Networks: the Role of Negative ties in Different Scales

PubMed Central

Esmailian, Pouya; Jalili, Mahdi

2015-01-01

Extracting community structure of complex network systems has many applications from engineering to biology and social sciences. There exist many algorithms to discover community structure of networks. However, it has been significantly under-explored for networks with positive and negative links as compared to unsigned ones. Trying to fill this gap, we measured the quality of partitions by introducing a Map Equation for signed networks. It is based on the assumption that negative relations weaken positive flow from a node towards a community, and thus, external (internal) negative ties increase the probability of staying inside (escaping from) a community. We further extended the Constant Potts Model, providing a map spectrum for signed networks. Accordingly, a partition is selected through balancing between abridgment and expatiation of a signed network. Most importantly, multi-scale spectrum of signed networks revealed how informative are negative ties in different scales, and quantified the topological placement of negative ties between dense positive ones. Moreover, an inconsistency was found in the signed Modularity: as the number of negative ties increases, the density of positive ties is neglected more. These results shed lights on the community structure of signed networks. PMID:26395815

DoD Workshop on Southeast Regional Planning and Sustainability

DTIC Science & Technology

2007-04-01

development (Berke, 2007). Weak plans and ordinances in these locations mean limited knowledge about existing human and natural resource systems...research on sustainable community design, and disseminate that knowledge through innovative teaching and outreach. Rather than serving as outside...technical work is being done to address these issues, much institutional change will be needed to tie this knowledge to advance regional plans and

Internet Freedom and Political Space

DTIC Science & Technology

2013-01-01

information across a wide range of different commu- nities. Thus, weak ties can deliver information in communities that are not interlinked with each... information .77 Such a top-down communication left little opportu- nity for grassroots input into the movement’s goals and its development of...Republic of Egypt, Ministry of Communications and Information Technologies, The Future of Internet Economy in Egypt: A Statistical Profile, May 2011

An epidemic model of rumor diffusion in online social networks

NASA Astrophysics Data System (ADS)

Cheng, Jun-Jun; Liu, Yun; Shen, Bo; Yuan, Wei-Guo

2013-01-01

So far, in some standard rumor spreading models, the transition probability from ignorants to spreaders is always treated as a constant. However, from a practical perspective, the case that individual whether or not be infected by the neighbor spreader greatly depends on the trustiness of ties between them. In order to solve this problem, we introduce a stochastic epidemic model of the rumor diffusion, in which the infectious probability is defined as a function of the strength of ties. Moreover, we investigate numerically the behavior of the model on a real scale-free social site with the exponent γ = 2.2. We verify that the strength of ties plays a critical role in the rumor diffusion process. Specially, selecting weak ties preferentially cannot make rumor spread faster and wider, but the efficiency of diffusion will be greatly affected after removing them. Another significant finding is that the maximum number of spreaders max( S) is very sensitive to the immune probability μ and the decay probability v. We show that a smaller μ or v leads to a larger spreading of the rumor, and their relationships can be described as the function ln(max( S)) = Av + B, in which the intercept B and the slope A can be fitted perfectly as power-law functions of μ. Our findings may offer some useful insights, helping guide the application in practice and reduce the damage brought by the rumor.

Risk Factors for Social Isolation in Older Korean Americans.

PubMed

Jang, Yuri; Park, Nan Sook; Chiriboga, David A; Yoon, Hyunwoo; Ko, Jisook; Lee, Juyoung; Kim, Miyong T

2016-02-01

Given the importance of social ties and connectedness in the lives of older ethnic immigrants, the present study examined the prevalence of social isolation and its risk factors in older Korean Americans. Using survey data from 1,301 participants (Mage = 70.5, SD = 7.24), risk groups for marginal social ties with family and friends were identified and predictors of each type of social isolation explored. Male gender and poorer rating of health were identified as common risk factors for marginal ties to both family and friends. Findings also present specific risk factors for each type of social isolation. For example, an increased risk of having marginal ties with friends was observed among individuals with perceived financial strain, greater functional impairment, and a shorter stay in the United States. The common and specific risk factors should be incorporated in programs to reduce social isolation in older immigrant populations. © The Author(s) 2015.

Exploring the Academic Benefits of Friendship Ties for Latino Boys and Girls*

PubMed

Riegle-Crumb, Catherine; Callahan, Rebecca M

2009-09-01

OBJECTIVES: We examine how the racial/ethnic and generational status composition of Latino students' friendship groups is related to their academic achievement and whether there are differential effects by gender. METHODS: We use multivariate regression analyses to examine the effects of friends' characteristics on Latino students' end of high school grades, utilizing data from the Adolescent Health and Academic Achievement Study (AHAA), and its parent survey, the National Longitudinal Study of Adolescent Health (Add Health). RESULTS: For Latina girls, there are positive effects of having more friendship ties to third-plus-generation Latino peers in contrast to dominant culture peers; yet Latino boys benefit academically from ties to all co-ethnic peers. Having friends with higher parental education promotes achievement of both genders. CONCLUSION: Our results counter notions of a pervasive negative peer influence of minority youth and suggest that co-ethnic ties are an important source of social capital for Latino students' achievement.

Enserch Garden Banks 388 field development template tie-back of existing subsea satellite wells

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hellums, J.W.; Granhaug, O.

1995-12-31

The Flowline Jumper System (FJS) will be used by Enserch Exploration, Inc. to tie in three existing wells to the 24 well production template installed in Garden Banks Block 388. The FJS allows these existing satellite wells to be connected to the production template via standard wellbays, eliminating the need for dedicated receiver structures, or tie-in porches. Wellbays used for satellite well tie-ins are available for use as template wells following the removal of the jumper. This paper describes the considerations that led to the selection and influenced the design of the FJS. The advantages of vertical jumper systems aremore » fully discussed with respect to the GB-388 Project. A description of the major components and how they interface with the template is included to provide a better understanding of the FJS. Also included is an outline of the System Integration Testing (SIT) of the FJS.« less

The Role of Attachment Style in Facebook Use and Social Capital: Evidence from University Students and a National Sample

PubMed Central

2015-01-01

Abstract Social networking sites (SNSs) can be beneficial tools for users to gain social capital. Although social capital consists of emotional and informational resources accumulated through interactions with strong or weak social network ties, the existing literature largely ignores attachment style in this context. This study employed attachment theory to explore individuals' attachment orientations toward Facebook usage and toward online and offline social capital. A university student sample (study 1) and a representative national sample (study 2) showed consistent results. Secure attachment was positively associated with online bonding and bridging capital and offline bridging capital. Additionally, secure attachment had an indirect effect on all capital through Facebook time. Avoidant attachment was negatively associated with online bonding capital. Anxious–ambivalent attachment had a direct association with online bonding capital and an indirect effect on all capital through Facebook. Interaction frequency with good friends on Facebook positively predicted all online and offline capital, whereas interaction frequency with average friends on Facebook positively predicted online bridging capital. Interaction frequency with acquaintances on Facebook was negatively associated with offline bonding capital. The study concludes that attachment style is a significant factor in guiding social orientation toward Facebook connections with different ties and influences online social capital. The study extends attachment theory among university students to a national sample to provide more generalizable evidence for the current literature. Additionally, this study extends attachment theory to the SNS setting with a nuanced examination of types of Facebook friends after controlling extraversion. Implications for future research are discussed. PMID:25751049

The role of attachment style in Facebook use and social capital: evidence from university students and a national sample.

PubMed

Lin, Jih-Hsuan

2015-03-01

Social networking sites (SNSs) can be beneficial tools for users to gain social capital. Although social capital consists of emotional and informational resources accumulated through interactions with strong or weak social network ties, the existing literature largely ignores attachment style in this context. This study employed attachment theory to explore individuals' attachment orientations toward Facebook usage and toward online and offline social capital. A university student sample (study 1) and a representative national sample (study 2) showed consistent results. Secure attachment was positively associated with online bonding and bridging capital and offline bridging capital. Additionally, secure attachment had an indirect effect on all capital through Facebook time. Avoidant attachment was negatively associated with online bonding capital. Anxious-ambivalent attachment had a direct association with online bonding capital and an indirect effect on all capital through Facebook. Interaction frequency with good friends on Facebook positively predicted all online and offline capital, whereas interaction frequency with average friends on Facebook positively predicted online bridging capital. Interaction frequency with acquaintances on Facebook was negatively associated with offline bonding capital. The study concludes that attachment style is a significant factor in guiding social orientation toward Facebook connections with different ties and influences online social capital. The study extends attachment theory among university students to a national sample to provide more generalizable evidence for the current literature. Additionally, this study extends attachment theory to the SNS setting with a nuanced examination of types of Facebook friends after controlling extraversion. Implications for future research are discussed.

"It's making contacts": notions of social capital and implications for widening access to medical education.

PubMed

Nicholson, S; Cleland, J A

2017-05-01

In the UK widening access (WA) activities and policies aim to increase the representation from lower socio-economic groups into Higher Education. Whilst linked to a political rhetoric of inclusive education such initiatives have however failed to significantly increase the number of such students entering medicine. This is compounded by a discourse that portrays WA applicants and students as lacking the essential skills or attributes to be successful in medical education. Much of the research in this area to date has been weak and it is critical to better understand how WA applicants and students negotiate medical admissions and education to inform change. To address this gap we amalgamated a larger dataset from three qualitative studies of student experiences of WA to medicine (48 participants in total). Inductively analysing the findings using social capital as a theoretical lens we created and clustered codes into categories, informed by the concepts of "weak ties" and "bridging and linking capital", terms used by previous workers in this field, to better understand student journeys in medical education. Successful applicants from lower socio-economic groups recognise and mobilise weak ties to create linking capital. However once in medical school these students seem less aware of the need for, or how to create, capital effectively. We argue WA activities should support increasing the social capital of under-represented applicants and students, and future selection policy needs to take into account the varying social capital of students, so as to not overtly disadvantage some social groups.

Defining Command, Leadership, and Management Success Factors Within Stability Operations

DTIC Science & Technology

2011-06-01

concepts are identified, and strengths, weaknesses, opportunities, and threats ( SWOT ) analysis is conducted. The enti- ties of the EU, NATO, and the...ICRC all receive a simi- lar treatment identifying their mandates and methods and having SWOT applied. The NATO discussions are continued in the...essence describes the prevention-interven- tion-stabilization curve in the current environment. The essential concepts from a stability operation con - text

Structure and evolution of online social relationships: Heterogeneity in unrestricted discussions.

PubMed

Goh, K-I; Eom, Y-H; Jeong, H; Kahng, B; Kim, D

2006-06-01

With the advancement in the information age, people are using electronic media more frequently for communications, and social relationships are also increasingly resorting to online channels. While extensive studies on traditional social networks have been carried out, little has been done on online social networks. Here we analyze the structure and evolution of online social relationships by examining the temporal records of a bulletin board system (BBS) in a university. The BBS dataset comprises of 1908 boards, in which a total of 7446 students participate. An edge is assigned to each dialogue between two students, and it is defined as the appearance of the name of a student in the from- and to-field in each message. This yields a weighted network between the communicating students with an unambiguous group association of individuals. In contrast to a typical community network, where intracommunities (intercommunities) are strongly (weakly) tied, the BBS network contains hub members who participate in many boards simultaneously but are strongly tied, that is, they have a large degree and betweenness centrality and provide communication channels between communities. On the other hand, intracommunities are rather homogeneously and weakly connected. Such a structure, which has never been empirically characterized in the past, might provide a new perspective on the social opinion formation in this digital era.

Circulating Angiopoietin-2 and Its Soluble Receptor Tie-2 Concentrations Are Related to Renal Function in Two Population-Based Cohorts

PubMed Central

Hennings, Anna; Hannemann, Anke; Rettig, Rainer; Dörr, Marcus; Nauck, Matthias; Völzke, Henry; Lerch, Markus M.; Lieb, Wolfgang; Friedrich, Nele

2016-01-01

Background An intact angiopoietin/Tie-2 ligand receptor system is indispensable for life. High circulating angiopoietin-2 (Ang-2) concentrations are strongly associated with kidney disease involving the progressive loss of glomerular filtration. The aim of our study was to investigate the associations between renal function and serum Ang-2 or serum Tie-2 concentrations in the general population. Methods Data of 3081 and 4088 subjects from two population-based studies, the Study of Health in Pomerania (SHIP-1) and SHIP-Trend, were used. Renal function was assessed by serum creatinine, cystatin C concentration, creatinine-based estimated glomerular filtration rate [eGFR(crea)], cystatin C-based eGFR [eGFR(cys)] and urinary albumin-to-creatinine ratio (uACR). Analyses of variance and linear regression models were calculated. Results In both cohorts, strong positive associations between serum cystatin C concentrations and serum Ang-2 or Tie-2 concentrations as well as inverse associations between eGFR(cys) and serum Ang-2 or Tie-2 concentrations were found. These relations were also present in a subpopulation without hypertension or diabetes mellitus type 2. Furthermore, we detected weak U-shaped associations between serum creatinine concentrations or eGFR(crea) and serum Ang-2 concentrations. With respect to uACR a strong positive association with serum Ang-2 concentrations was revealed. Conclusion Serum Ang-2 concentrations are strongly associated with sensitive parameters of renal impairment like serum cystatin C, uACR and eGFR(cys). These findings persisted even after exclusion of subjects with hypertension or diabetes mellitus type 2, conditions that predispose to chronic renal disease and are associated with increased Ang-2 concentrations. Interestingly, we did not detect the same strong relations between serum creatinine and eGFR(crea) with serum Ang-2 concentration. Additionally, significant association of serum Tie-2 concentrations with cystatin C and eGFR(cys) were detected. PMID:27893762

Circulating Angiopoietin-2 and Its Soluble Receptor Tie-2 Concentrations Are Related to Renal Function in Two Population-Based Cohorts.

PubMed

Hennings, Anna; Hannemann, Anke; Rettig, Rainer; Dörr, Marcus; Nauck, Matthias; Völzke, Henry; Lerch, Markus M; Lieb, Wolfgang; Friedrich, Nele

2016-01-01

An intact angiopoietin/Tie-2 ligand receptor system is indispensable for life. High circulating angiopoietin-2 (Ang-2) concentrations are strongly associated with kidney disease involving the progressive loss of glomerular filtration. The aim of our study was to investigate the associations between renal function and serum Ang-2 or serum Tie-2 concentrations in the general population. Data of 3081 and 4088 subjects from two population-based studies, the Study of Health in Pomerania (SHIP-1) and SHIP-Trend, were used. Renal function was assessed by serum creatinine, cystatin C concentration, creatinine-based estimated glomerular filtration rate [eGFR(crea)], cystatin C-based eGFR [eGFR(cys)] and urinary albumin-to-creatinine ratio (uACR). Analyses of variance and linear regression models were calculated. In both cohorts, strong positive associations between serum cystatin C concentrations and serum Ang-2 or Tie-2 concentrations as well as inverse associations between eGFR(cys) and serum Ang-2 or Tie-2 concentrations were found. These relations were also present in a subpopulation without hypertension or diabetes mellitus type 2. Furthermore, we detected weak U-shaped associations between serum creatinine concentrations or eGFR(crea) and serum Ang-2 concentrations. With respect to uACR a strong positive association with serum Ang-2 concentrations was revealed. Serum Ang-2 concentrations are strongly associated with sensitive parameters of renal impairment like serum cystatin C, uACR and eGFR(cys). These findings persisted even after exclusion of subjects with hypertension or diabetes mellitus type 2, conditions that predispose to chronic renal disease and are associated with increased Ang-2 concentrations. Interestingly, we did not detect the same strong relations between serum creatinine and eGFR(crea) with serum Ang-2 concentration. Additionally, significant association of serum Tie-2 concentrations with cystatin C and eGFR(cys) were detected.

Toward a Behavioral Approach to Privacy for Online Social Networks

NASA Astrophysics Data System (ADS)

Banks, Lerone D.; Wu, S. Felix

We examine the correlation between user interactions and self reported information revelation preferences for users of the popular Online Social Network (OSN), Facebook. Our primary goal is to explore the use of indicators of tie strength to inform localized, per-user privacy preferences for users and their ties within OSNs. We examine the limitations of such an approach and discuss future plans to incorporate this approach into the development of an automated system for helping users define privacy policy. As part of future work, we discuss how to define/expand policy to the entire social network. We also present additional collected data similar to other studies such as perceived tie strength and information revelation preferences for OSN users.

Typical intellectual engagement and cognition in the ninth decade of life: The Lothian Birth Cohort 1921.

PubMed

von Stumm, Sophie; Deary, Ian J

2012-09-01

Investment traits--the tendency to seek out and engage in cognitive activity--might affect intellectual growth across the life span, specifically the development from fluid to crystallized intelligence. Here we explore how childhood IQ at age 11 years, IQ at age 79, and the investment trait Typical Intellectual Engagement (TIE) at age 81 affect the mean level and change in verbal fluency scores, used as an indicator of crystallized intelligence, across the ages 79, 83, and 87 in the Lothian Birth Cohort 1921 (maximum N = 569; Deary, Whiteman, Starr, Whalley, & Fox, 2004). A first latent growth model showed significant variance in the mean level of verbal fluency and significant decline in verbal fluency from age 79 to age 87. The rate of change was invariant across study participants in the Lothian Birth Cohort 1921. A second model found that IQ at age 11 significantly predicted IQ at age 79 (β = .66; p < .001), which in turn predicted verbal fluency and TIE in the ninth decade of life with standardized path parameters of .46 and .15 (p < .001), respectively. TIE had a significant association with verbal fluency (β = .14, p = .002); together, IQ at age 11 and 79 and TIE accounted for 25.5% of the variance in verbal fluency. A final model identified the TIE subfactor of intellectual curiosity as a significant mediator of the effect of IQ on verbal fluency; the TIE subfactors abstract thinking, reading, and problem solving showed no significant associations. In summary, TIE--in particular, intellectual curiosity--significantly mediated the effects of IQ on crystallized intelligence in old age. Because there was no significant between-subjects variance in verbal fluency trajectories in the current study, neither TIE nor IQ were associated with individual differences in cognitive decline.

A Case Study of International Students' Social Adjustment, Friendship Development, and Physical Activity

ERIC Educational Resources Information Center

Li, Shuang; Zizzi, Sam

2018-01-01

Previous literature has focused on international student's social transition and monocultural and bicultural ties. Little research has explored international students' multicultural friendship development and the role that physical activity plays in their social interaction. The current case study explored a group of international students'…

The Conundrum of Functional Brain Networks: Small-World Efficiency or Fractal Modularity

PubMed Central

Gallos, Lazaros K.; Sigman, Mariano; Makse, Hernán A.

2012-01-01

The human brain has been studied at multiple scales, from neurons, circuits, areas with well-defined anatomical and functional boundaries, to large-scale functional networks which mediate coherent cognition. In a recent work, we addressed the problem of the hierarchical organization in the brain through network analysis. Our analysis identified functional brain modules of fractal structure that were inter-connected in a small-world topology. Here, we provide more details on the use of network science tools to elaborate on this behavior. We indicate the importance of using percolation theory to highlight the modular character of the functional brain network. These modules present a fractal, self-similar topology, identified through fractal network methods. When we lower the threshold of correlations to include weaker ties, the network as a whole assumes a small-world character. These weak ties are organized precisely as predicted by theory maximizing information transfer with minimal wiring costs. PMID:22586406

Network Ecology and Adolescent Social Structure

PubMed Central

McFarland, Daniel A.; Moody, James; Diehl, David; Smith, Jeffrey A.; Thomas, Reuben J.

2014-01-01

Adolescent societies—whether arising from weak, short-term classroom friendships or from close, long-term friendships—exhibit various levels of network clustering, segregation, and hierarchy. Some are rank-ordered caste systems and others are flat, cliquish worlds. Explaining the source of such structural variation remains a challenge, however, because global network features are generally treated as the agglomeration of micro-level tie-formation mechanisms, namely balance, homophily, and dominance. How do the same micro-mechanisms generate significant variation in global network structures? To answer this question we propose and test a network ecological theory that specifies the ways features of organizational environments moderate the expression of tie-formation processes, thereby generating variability in global network structures across settings. We develop this argument using longitudinal friendship data on schools (Add Health study) and classrooms (Classroom Engagement study), and by extending exponential random graph models to the study of multiple societies over time. PMID:25535409

Network Ecology and Adolescent Social Structure.

PubMed

McFarland, Daniel A; Moody, James; Diehl, David; Smith, Jeffrey A; Thomas, Reuben J

2014-12-01

Adolescent societies-whether arising from weak, short-term classroom friendships or from close, long-term friendships-exhibit various levels of network clustering, segregation, and hierarchy. Some are rank-ordered caste systems and others are flat, cliquish worlds. Explaining the source of such structural variation remains a challenge, however, because global network features are generally treated as the agglomeration of micro-level tie-formation mechanisms, namely balance, homophily, and dominance. How do the same micro-mechanisms generate significant variation in global network structures? To answer this question we propose and test a network ecological theory that specifies the ways features of organizational environments moderate the expression of tie-formation processes, thereby generating variability in global network structures across settings. We develop this argument using longitudinal friendship data on schools (Add Health study) and classrooms (Classroom Engagement study), and by extending exponential random graph models to the study of multiple societies over time.

Method and apparatus for constructing an underground barrier wall structure

DOEpatents

Dwyer, Brian P.; Stewart, Willis E.; Dwyer, Stephen F.

2002-01-01

A method and apparatus for constructing a underground barrier wall structure using a jet grout injector subassembly comprising a pair of primary nozzles and a plurality of secondary nozzles, the secondary nozzles having a smaller diameter than the primary nozzles, for injecting grout in directions other than the primary direction, which creates a barrier wall panel having a substantially uniform wall thickess. This invention addresses the problem of the weak "bow-tie" shape that is formed during conventional jet injection when using only a pair of primary nozzles. The improvement is accomplished by using at least four secondary nozzles, of smaller diameter, located on both sides of the primary nozzles. These additional secondary nozzles spray grout or permeable reactive materials in other directions optimized to fill in the thin regions of the bow-tie shape. The result is a panel with increased strength and substantially uniform wall thickness.

Social capital and health: civic engagement, community size, and recall of health messages.

PubMed

Viswanath, Kasisomayajula; Randolph Steele, Whitney; Finnegan, John R

2006-08-01

We explored the effects of community integration and pluralism on recall of cardiovascular disease health information messages. With 1980-1983 data from the Minnesota Heart Health Program, we examined whether ties to community groups were associated with recall of health messages, and whether this relation was modified by size and degree of differentiation of the community. A higher level of civic engagement through ties to community groups was associated with better recall of health messages. Ties to community groups independently contributed to better message recall even after control for gender, education, and other variables. The moderating role of community size was non-significant but intriguing. Community group membership could increase exposure to health messages, providing a critical pathway for social capital to influence health promotion and, thus, public health outcomes.

Problems of Anti-Bacteriological Defense: According to Data from Foreign Literature

DTIC Science & Technology

1961-10-01

tuberculosis . The illness usually starts ;’rad- lually with general malaise, weakness, emaciation. The duration of the disease ranges from 2 - 3 months...proper- ties the nocardia stands very close to the actinomycetes and the agent of tuberculosis , its relatively high degree of resistance Ls totb assumed...diagnosis was es- tablished only in the terminal stage or even at autoDsy. The clinical signs of the illness are very similar to! tuberculosis . The

Analyzing Ukraine’s Prospects for NATO Membership

DTIC Science & Technology

2008-12-01

the Ukrainian language as ‘ bourgeoisie nationalism.’”61 Even though Kravchuk had ties to the former Soviet regime, he sought to strengthen Ukraine’s...Ukraine’s qualifications for a MAP are weak, and in part because they are concerned about damaging relations with Russia.”187 Germany and France in...Allies seem to indicate that this situation has not changed. In April 2008, Francois Fillon, the Prime Minister of France , stated that “ France will

Fighting Dark Networks: Using Social Network Analysis to Implement the Special Operations Targeting Process for Direct and Indirect Approaches

DTIC Science & Technology

2013-03-01

Wouter De Nooy, Andrej Mrvar and Vladimir Batagelj , Exploratory Social Network Analysis with Pajek, (New York: Cambridge University Press, 2005), 5...Granovetter, “The Strength of Weak Ties,” 1350–1368. 151 de Nooy, Mrvar , and Batagelj , Exploratory Social Network Analysis with Pajek, 151. 152...Spacetime Wrinkles Exhibit (1995). de Nooy, Wouter, Andrej Mrvar , and Vladimir Batagelj . Exploratory Social Network Analysis with Pajek. Cambridge

Mine safety assessment using gray relational analysis and bow tie model

PubMed Central

2018-01-01

Mine safety assessment is a precondition for ensuring orderly and safety in production. The main purpose of this study was to prevent mine accidents more effectively by proposing a composite risk analysis model. First, the weights of the assessment indicators were determined by the revised integrated weight method, in which the objective weights were determined by a variation coefficient method and the subjective weights determined by the Delphi method. A new formula was then adopted to calculate the integrated weights based on the subjective and objective weights. Second, after the assessment indicator weights were determined, gray relational analysis was used to evaluate the safety of mine enterprises. Mine enterprise safety was ranked according to the gray relational degree, and weak links of mine safety practices identified based on gray relational analysis. Third, to validate the revised integrated weight method adopted in the process of gray relational analysis, the fuzzy evaluation method was used to the safety assessment of mine enterprises. Fourth, for first time, bow tie model was adopted to identify the causes and consequences of weak links and allow corresponding safety measures to be taken to guarantee the mine’s safe production. A case study of mine safety assessment was presented to demonstrate the effectiveness and rationality of the proposed composite risk analysis model, which can be applied to other related industries for safety evaluation. PMID:29561875

Exploring Innovative Entrepreneurship and Its Ties to Higher Educational Experiences

ERIC Educational Resources Information Center

Mayhew, Matthew J.; Simonoff, Jeffrey S.; Baumol, William J.; Wiesenfeld, Batia M.; Klein, Michael W.

2012-01-01

The purpose of this paper was to explore innovative entrepreneurship and to gain insight into the educational practices and experiences that increase the likelihood that a student would graduate with innovative entrepreneurial intentions. To this end, we administered a battery of assessments to 3,700 undergraduate seniors who matriculated in the…

Consequences of Arizona's Immigration Policy on Social Capital among Mexican Mothers with Unauthorized Immigration Status

ERIC Educational Resources Information Center

Valdez, Carmen R.; Padilla, Brian; Valentine, Jessa Lewis

2013-01-01

This study explores the consequences of increasingly restrictive immigration policies on social capital among Mexican mothers with unauthorized immigrant status in Arizona. Three focus groups conducted in Arizona explore how mothers' experiences with immigration policies have affected their neighborhood, community, and family ties. Focus group…

International Environmental Law and Biochemistry: An Innovative Teaching Opportunity.

ERIC Educational Resources Information Center

Candlish, John

1998-01-01

Explores the ties between international environmental law and biochemistry with respect to genetically modified organisms, biodiversity, marine pollution, cancer biology, and pesticide contamination of food. Contains 30 references. (DDR)

Social Capital and Health: Civic Engagement, Community Size, and Recall of Health Messages

PubMed Central

Viswanath, Kasisomayajula; Randolph Steele, Whitney; Finnegan, John R.

2006-01-01

Objectives. We explored the effects of community integration and pluralism on recall of cardiovascular disease health information messages. Methods. With 1980–1983 data from the Minnesota Heart Health Program, we examined whether ties to community groups were associated with recall of health messages, and whether this relation was modified by size and degree of differentiation of the community. Results. A higher level of civic engagement through ties to community groups was associated with better recall of health messages. Ties to community groups independently contributed to better message recall even after control for gender, education, and other variables. The moderating role of community size was non-significant but intriguing. Conclusions. Community group membership could increase exposure to health messages, providing a critical pathway for social capital to influence health promotion and, thus, public health outcomes. PMID:16809608

Social networks, migration, and HIV testing among Latinos in a new immigrant destination: Insights from a qualitative study.

PubMed

Barrington, Clare; Gandhi, Anisha; Gill, Adrienne; Villa Torres, Laura; Brietzke, Maria Priscila; Hightow-Weidman, Lisa

2017-12-03

Latinos in the U.S. are disproportionately affected by HIV and are more likely than non-Latinos to present with a late diagnosis, which delays engagement in HIV care and treatment. Social networks may provide normative influence and social support for HIV testing, but a contextualised understanding of networks is needed in order to maximise these social resources. We conducted qualitative interviews with foreign-born Latino men and transgender women (n = 17) in a new immigrant destination to explore their social networks. Most participants described having smaller social networks after migrating. Networks included both local and transnational ties, but most participants had few close ties. Contextual factors including stigma and geographic dispersion limited the re-construction of networks with close ties after migration. HIV testing was not a common topic of discussion with social network ties. Efforts to improve early uptake of HIV testing among Latino immigrants may benefit from engaging with social networks, but such efforts need to address how the context in which networks operate enables access to testing.

Analysis of ILRS Site Ties

NASA Astrophysics Data System (ADS)

Husson, V. S.; Long, J. L.; Pearlman, M.

2001-12-01

By the end of 2000, 94% of ILRS stations had completed station and site information forms (i.e. site logs). These forms contain six types of information. These six categories include site identifiers, contact information, approximate coordinates, system configuration history, system ranging capabilities, and local survey ties. The ILRS Central Bureau, in conjunction with the ILRS Networks and Engineering Working Group, has developed procedures to quality control site log contents. Part of this verification entails data integrity checks of local site ties and is the primary focus of this paper. Local survey ties are critical to the combination of space geodetic network coordinate solutions (i.e. GPS, SLR, VLBI, DORIS) of the International Terrestrial Reference Frame (ITRF). Approximately 90% of active SLR sites are collocated with at least one other space geodetic technique. The process used to verify these SLR ties, at collocated sites, is identical to the approach used in ITRF2000. Local vectors (X, Y, Z) from each ILRS site log are differenced from its corresponding ITRF2000 position vectors (i.e. no transformations). These X, Y, and Z deltas are converted into North, East, and Up. Any deltas, in any component, larger than 5 millimeter is flagged for investigation. In the absence of ITRF2000 SLR positions, CSR positions were used. To further enhance this comparison and to fill gaps in information, local ties contained in site logs from the other space geodetic services (i.e. IGS, IVS, IDS) were used in addition to ITRF2000 ties. Case studies of two collocated sites (McDonald/Ft. Davis and Hartebeeshtoek) will be explored in-depth. Recommendations on how local site surveys should be conducted and how this information should be managed will also be presented.

Effects of Nano-Hydroxyapatite/Polyetheretherketone-Coated, Sandblasted, Large-Grit, and Acid-Etched Implants on Inflammatory Cytokines and Osseointegration in a Peri-Implantitis Model in Beagle Dogs.

PubMed

Yang, Hua-Wei; Tang, Xiao-Shan; Tian, Zhuo-Wei; Wang, Yang; Yang, Wen-Yi; Hu, Jing-Zhou

2017-09-25

BACKGROUND This study explored the effects of nano-hydroxyapatite/polyetheretherketone (n-HA/PEEK)- coated sandblasted, large-grit, and acid-etched (SLA) implants on inflammatory cytokines and osseointegration in peri-implantitis model beagle dogs. MATERIAL AND METHODS Peri-implantitis models were established. Eight beagle dogs were randomly and evenly assigned into SLA tied, SLA + n-HA/PEEK tied, SLA untied, or SLA + n-HA/PEEK untied groups. A special periodontal probe was used to detect the plaque index (PLI), probing depth (PD), and modified Sulcus Bleeding Index (mSBI). Gingival crevicular fluid was collected and an ELISA kit was utilized to detect IL-1, IL-6, and IL-17 levels. The colony-forming units were counted and the maximum shear strength of implants was tested using the axial pullout test. HE staining was used to detect the inflammation of peri-implant bone tissues. Osseointegration was observed through toluidine blue staining. Bone-to-implant contact (BIC) was obtained through histological observation and the mineral apposition rate (MAR) was calculated after immune fluorescent double staining. RESULTS The SLA tied group demonstrated higher levels of PLI, PD, mSBI, IL-1, IL-6, and IL-17 and a higher degree of inflammation than the SLA + n-HA/PEEK tied group. The tied groups also displayed similar results over the untied groups at the same time point. The maximum shear strength, BIC, and MAR in the SLA tied group were significantly lower than in the SLA + n-HA/PEEK tied group. CONCLUSIONS Our findings demonstrate that SLA + n-HA/PEEK implants can promote osseointegration and relieve the inflammation response of peri-implantitis in beagle dogs.

To participate or not in the physician quality reporting initiative (PQRI); that is the question.

PubMed

Elliott, Brett

2007-05-01

The Tax Relief and Health Care Act of 2006 authorized the establishment of a physician quality reporting system which would tie a reimbursement incentive to compliance with benchmarks that are considered proxies of quality patient care. The Centers for Medicare and Medicare Services (CMS) has called this the Physician Quality Reporting Initiative (PQRI). A brief historical background about how this program evolved, how one participates in this initiative, and the strengths and weaknesses of current and new benchmarks is presented.

The Ties that Bind and the Shackles that Separate: Race, Gender, Class, and Color in a Research Process.

ERIC Educational Resources Information Center

Johnson-Bailey, Juanita

1999-01-01

Explores the intricacies of researching within one's own culture. Addresses issues that arose when an African-American woman researcher interviewed other African-American women. Explores how race and gender brought the author closer to the participants and the effects of color differences and perceived class differences. (CMK)

Evaluation of HIV testing algorithms in Ethiopia: the role of the tie-breaker algorithm and weakly reacting test lines in contributing to a high rate of false positive HIV diagnoses.

PubMed

Shanks, Leslie; Siddiqui, M Ruby; Kliescikova, Jarmila; Pearce, Neil; Ariti, Cono; Muluneh, Libsework; Pirou, Erwan; Ritmeijer, Koert; Masiga, Johnson; Abebe, Almaz

2015-02-03

In Ethiopia a tiebreaker algorithm using 3 rapid diagnostic tests (RDTs) in series is used to diagnose HIV. Discordant results between the first 2 RDTs are resolved by a third 'tiebreaker' RDT. Médecins Sans Frontières uses an alternate serial algorithm of 2 RDTs followed by a confirmation test for all double positive RDT results. The primary objective was to compare the performance of the tiebreaker algorithm with a serial algorithm, and to evaluate the addition of a confirmation test to both algorithms. A secondary objective looked at the positive predictive value (PPV) of weakly reactive test lines. The study was conducted in two HIV testing sites in Ethiopia. Study participants were recruited sequentially until 200 positive samples were reached. Each sample was re-tested in the laboratory on the 3 RDTs and on a simple to use confirmation test, the Orgenics Immunocomb Combfirm® (OIC). The gold standard test was the Western Blot, with indeterminate results resolved by PCR testing. 2620 subjects were included with a HIV prevalence of 7.7%. Each of the 3 RDTs had an individual specificity of at least 99%. The serial algorithm with 2 RDTs had a single false positive result (1 out of 204) to give a PPV of 99.5% (95% CI 97.3%-100%). The tiebreaker algorithm resulted in 16 false positive results (PPV 92.7%, 95% CI: 88.4%-95.8%). Adding the OIC confirmation test to either algorithm eliminated the false positives. All the false positives had at least one weakly reactive test line in the algorithm. The PPV of weakly reacting RDTs was significantly lower than those with strongly positive test lines. The risk of false positive HIV diagnosis in a tiebreaker algorithm is significant. We recommend abandoning the tie-breaker algorithm in favour of WHO recommended serial or parallel algorithms, interpreting weakly reactive test lines as indeterminate results requiring further testing except in the setting of blood transfusion, and most importantly, adding a confirmation test to the RDT algorithm. It is now time to focus research efforts on how best to translate this knowledge into practice at the field level. Clinical Trial registration #: NCT01716299.

Quasi-static and dynamic magnetic tension forces in arched, line-tied magnetic flux ropes

DOE Office of Scientific and Technical Information (OSTI.GOV)

Myers, C. E.; Yamada, M.; Ji, H.

Solar eruptions are often driven by magnetohydrodynamic instabilities such as the torus and kink instabilities that act on line-tied magnetic flux ropes. We designed our recent laboratory experiments to study these eruptive instabilities which have demonstrated the key role of both dynamic (Myers et al 2015 Nature 528 526) and quasi-static (Myers et al 2016 Phys. Plasmas 23 112102) magnetic tension forces in contributing to the equilibrium and stability of line-tied magnetic flux ropes. In our paper, we synthesize these laboratory results and explore the relationship between the dynamic and quasi-static tension forces. And while the quasi-static tension force ismore » found to contribute to the flux rope equilibrium in a number of regimes, the dynamic tension force is substantial mostly in the so-called failed torus regime where magnetic self-organization events prevent the flux rope from erupting.« less

Quasi-static and dynamic magnetic tension forces in arched, line-tied magnetic flux ropes

DOE PAGES

Myers, C. E.; Yamada, M.; Ji, H.; ...

2016-11-22

Solar eruptions are often driven by magnetohydrodynamic instabilities such as the torus and kink instabilities that act on line-tied magnetic flux ropes. We designed our recent laboratory experiments to study these eruptive instabilities which have demonstrated the key role of both dynamic (Myers et al 2015 Nature 528 526) and quasi-static (Myers et al 2016 Phys. Plasmas 23 112102) magnetic tension forces in contributing to the equilibrium and stability of line-tied magnetic flux ropes. In our paper, we synthesize these laboratory results and explore the relationship between the dynamic and quasi-static tension forces. And while the quasi-static tension force ismore » found to contribute to the flux rope equilibrium in a number of regimes, the dynamic tension force is substantial mostly in the so-called failed torus regime where magnetic self-organization events prevent the flux rope from erupting.« less

Stigma Management Trajectories in Youth with Perinatally Acquired HIV and Their Families: A Qualitative Perspective.

PubMed

Proulx-Boucher, Karène; Fernet, Mylène; Blais, Martin; Lapointe, Normand; Samson, Johanne; Lévy, Joseph J; Otis, Joanne; Morin, Guylaine; Thériault, Jocelyne; Trottier, Germain

2017-09-01

This study explores how family, secrecy and silence contribute to the adoption of stigma management strategies among youth with perinatally acquired HIV (PAHIV). A qualitative method was used. Eighteen youths with PAHIV aged 13-22 years old took part in a semi-structured interview. An exploratory content analysis was performed. Analyses of interviews allowed identification of two HIV stigma management trajectories, both sensitive to the family context: [1] a consolidation of family ties, which contributes to solidarity in stigma management; and [2] a weakening or dissolution of family ties, which contributes to solitary stigma management strategy. Family conditions that support the children in their efforts to develop active stigma management strategies are described. Children likely to experience weakening or dissolution family ties must build strong bonds in the clinical environment and maintain these into adulthood so as to afford them the support they need.

Friends or Foes? Relational Dissonance and Adolescent Psychological Wellbeing

PubMed Central

Bond, Lyndal; Lusher, Dean; Williams, Ian; Butler, Helen

2014-01-01

The interaction of positive and negative relationships (i.e. I like you, but you dislike me – referred to as relational dissonance) is an underexplored phenomenon. Further, it is often only poor (or negative) mental health that is examined in relation to social networks, with little regard for positive psychological wellbeing. Finally, these issues are compounded by methodological constraints. This study explores a new concept of relational dissonance alongside mutual antipathies and friendships and their association with mental health using multivariate exponential random graph models with an Australian sample of secondary school students. Results show male students with relationally dissonant ties have lower positive mental health measures. Girls with relationally dissonant ties have lower depressed mood, but those girls being targeted by negative ties are more likely to have depressed mood. These findings have implications for the development of interventions focused on promoting adolescent wellbeing and consideration of the appropriate measurement of wellbeing and mental illness. PMID:24498257

Perspectives on evolving dental care payment and delivery models.

PubMed

Rubin, Marcie S; Edelstein, Burton L

2016-01-01

Health care reform is well under way in the United States as reflected in evolving delivery, financing, and payment approaches that are affecting medicine ahead of dentistry. The authors explored health systems changes under way, distinguished historical and organizational differences between medicine and dentistry, and developed alternative models to characterize the relationships between these professions. The authors explored a range of medical payment approaches, including those tied to objective performance metrics, and their potential application to dentistry. Advances in understanding the essential role of oral health in general health have pulled dentistry into the broader discussion of care integration and payment reform. Dentistry's fit with primary and specialty medical care may take a variety of forms. Common provider payment approaches in dentistry-fee-for-service, capitation, and salary-are tied insufficiently to performance when measured as either health processes or health outcomes. Dentistry can anticipate potential payment reforms by observing changes already under way in medicine and by understanding alternative payment approaches that are tied to performance metrics, such as those now in development by the Dental Quality Alliance and others. Novel forms of dental practice may be expected to evolve continuously as medical-dental integration and payment reforms that promote accountability evolve. Copyright © 2016 American Dental Association. Published by Elsevier Inc. All rights reserved.

The association between network social capital and self-rated health: pouring old wine in new bottles?

PubMed

Verhaeghe, Pieter-Paul; Pattyn, Elise; Bracke, Piet; Verhaeghe, Mieke; Van De Putte, Bart

2012-03-01

This study examines whether there is an association between network social capital and self-rated health after controlling for social support. Moreover, we distinguish between network social capital that emerges from strong ties and weak ties. We used a cross-sectional representative sample of 815 adults from the Belgian population. Social capital is measured with the position generator and perceived social support with the MOS Social Support-scale. Results suggest that network social capital is associated with self-rated health after adjustment for social support. Because different social classes have access to different sets of resources, resources of friends and family from the intermediate and higher service classes are beneficial for self-rated health, whereas resources of friends and family from the working class appear to be rather detrimental for self-rated health. From a health-promoting perspective, these findings indicate that policy makers should deal with the root causes of socioeconomic disadvantages in society. Copyright © 2011 Elsevier Ltd. All rights reserved.

Optimal social-networking strategy is a function of socioeconomic conditions.

PubMed

Oishi, Shigehiro; Kesebir, Selin

2012-12-01

In the two studies reported here, we examined the relation among residential mobility, economic conditions, and optimal social-networking strategy. In study 1, a computer simulation showed that regardless of economic conditions, having a broad social network with weak friendship ties is advantageous when friends are likely to move away. By contrast, having a small social network with deep friendship ties is advantageous when the economy is unstable but friends are not likely to move away. In study 2, we examined the validity of the computer simulation using a sample of American adults. Results were consistent with the simulation: American adults living in a zip code where people are residentially stable but economically challenged were happier if they had a narrow but deep social network, whereas in other socioeconomic conditions, people were generally happier if they had a broad but shallow networking strategy. Together, our studies demonstrate that the optimal social-networking strategy varies as a function of socioeconomic conditions.

"A Gentleman's Handshake": The Role of Social Capital and Trust in Transforming Information into Usable Knowledge

ERIC Educational Resources Information Center

Fisher, Rhiannon

2013-01-01

This paper explores the role of various social ties in building trust and providing opportunities for information acquisition and knowledge exchange (IAKE). Social capital is used as a vehicle to explore the relationships between farmers and their advisors using bovine tuberculosis (bTB), a major disease facing the English cattle industry, as a…

The role of the geophysical template and environmental regimes in controlling stream-living trout populations

Treesearch

Brooke E. Penaluna; Steve F. Railsback; Jason B. Dunham; Sherri Johnson; Robert E. Bilby; Arne E. Skaugset; Michael Bradford

2015-01-01

The importance of multiple processes and instream factors to aquatic biota has been explored extensively, but questions remain about how local spatiotemporal variability of aquatic biota is tied to environmental regimes and the geophysical template of streams. We used an individual-based trout model to explore the relative role of the geophysical template versus...

Exploring relationship between human mobility and social ties: Physical distance is not dead

NASA Astrophysics Data System (ADS)

Jin, Bo; Liao, Binbing; Yuan, Ning; Wang, Wenjun

2015-06-01

Partly due to the difficulty of the access to a worldwide dataset that simultaneously captures the location history and social networks, our understanding of the relationship between human mobility and the social ties has been limited. However, this topic is essential for a deeper study from human dynamics and social networks aspects. In this paper, we examine the location history data and social networks data of 712 email users and 399 offline events users from a map-editing based social network website. Based on these data, we expand all our experiment both from individual aspect and community aspect. We find that the physical distance is still the most influential factor to social ties among the nine representative human mobility features extracted from our GPS trajectory dataset, although Internet revolution has made long-distance communication dramatically faster, easier and cheaper than ever before, and in turn, partly expand the physical scope of social networks. Furthermore, we find that to a certain extent, the proximity of South-North direction is more influential than East-West direction to social ties. To the our best of our knowledge, this difference between South-North and East-West is the first time to be raised and quantitatively supported by a large dataset. We believe our findings on the interplay of human mobility and social ties offer a new perspective to this field of study.

Older Veteran Digital Disparities: Examining the Potential for Solutions Within Social Networks

PubMed Central

Hogan, Timothy P; Richardson, Lorilei M; Cioffari-Bailiff, Lisa; Harvey, Kimberly; Houston, Thomas K

2016-01-01

Background Older adults typically have less access to the Internet than other age groups, and older Veterans may use the Internet even less due to economic and geographic reasons. Objective To explore solutions to this problem, our study examined older Veterans’ reported ability to access technology through their close social ties. Methods Data were collected via mail survey from a sample of Veterans aged 65 years and older (N=266). Results Nearly half (44.0%, 117/266) of the sample reported having no Internet access. Yet, among those without current access, older Veterans reported having a median of 5 (IQR 7) close social ties with home Internet access. These older Veterans also reported that they would feel comfortable asking a median of 2 (IQR 4) social ties for help to access the Internet, and that a median of 2 (IQR 4) social ties would directly access the Internet for the older Veteran to help with health management. Conclusions Findings suggest that even older Veterans without current Internet access have at least two social ties with home Internet who could be called upon for technology support. Thus, older Veterans may be willing to call upon these “surrogate seekers” for technology assistance and support in health management. This has implications for the digital divide, technology design, and health care policy. PMID:27881361

The Physical-Digital Divide: Exploring the Social Gap Between Digital Natives and Physical Natives.

PubMed

Ball, Christopher; Francis, Jessica; Huang, Kuo-Ting; Kadylak, Travis; Cotten, Shelia R; Rikard, R V

2017-09-01

Older adults are the most digitally divided demographic group. The present study explores how older adults perceive the physical use of information and communication technologies (ICTs), particularly across generations and contexts. Data for the present study come from nine focus groups. Seniors acknowledge that ICTs help them connect with geographically distant social ties, but that they lead to feelings of disconnection with geographically close social ties. We label this phenomenon the "physical-digital divide," which exists when a group feels ostracized or offended when those around them engage with ICTs while they themselves are not or cannot engage with ICTs. Younger generations are often referred to as "digital natives" and older generations as "digital immigrants." A more apt label for older adults may be "physical natives," as their preferred method of communication involves physical face-to-face interactions and traditional codes of etiquette. Suggestions are made for reducing the physical-digital divide.

How Social Ties Influence Consumer: Evidence from Event-Related Potentials.

PubMed

Luan, Jing; Yao, Zhong; Bai, Yan

2017-01-01

A considerable amount of marketing research has reported that consumers are more saliently influenced by friends (strong social ties) than by acquaintances and strangers (weak social ties). To shed light on the neural and psychological processes underlying such phenomenon, in this study we designed an amended S1-S2 paradigm (product-[reviewer-review]) that is based on realistic consumer purchase experiences. After incoming all given information (product, reviewer, review), participants were required to state their purchase intentions. The neurocognitive and emotional processes related to friend and stranger stimuli were delineated to suggest how social ties influence consumers during their shopping processes. Larger P2 (fronto-central scalp areas) and P3 (central and posterior-parietal scalp areas) components under stranger condition were elicited successfully. These findings demonstrate that the cognitive and emotional processing of friend and stranger stimuli occurs at stages of neural activity, and can be indicated by the P2 and P3 components. Electrophysiological data also support the hypothesis that different neural and emotional processing magnitude and strength underlie friend and stranger effect in the context of consumer purchase. During this process, the perception of stimuli evoked P2, subsequently emotional processing and attention modulation were activated and indicated by P2 and P3. The friend dominated phenomenon can be interpreted as the result of distinctive neurocognitive and emotional processing magnitude, which suggests that psychological and emotional factors can guide consumer decision making. This study consolidates that event related potential (ERP) methodology is likely to be a more sensitive method for investigating consumer behaviors. From the perspectives of management and marketing, our findings show that the P2 and P3 components can be employed as an indicator to probe the influential factors of consumer purchase intentions.

How Social Ties Influence Consumer: Evidence from Event-Related Potentials

PubMed Central

Yao, Zhong

2017-01-01

A considerable amount of marketing research has reported that consumers are more saliently influenced by friends (strong social ties) than by acquaintances and strangers (weak social ties). To shed light on the neural and psychological processes underlying such phenomenon, in this study we designed an amended S1-S2 paradigm (product-[reviewer-review]) that is based on realistic consumer purchase experiences. After incoming all given information (product, reviewer, review), participants were required to state their purchase intentions. The neurocognitive and emotional processes related to friend and stranger stimuli were delineated to suggest how social ties influence consumers during their shopping processes. Larger P2 (fronto-central scalp areas) and P3 (central and posterior-parietal scalp areas) components under stranger condition were elicited successfully. These findings demonstrate that the cognitive and emotional processing of friend and stranger stimuli occurs at stages of neural activity, and can be indicated by the P2 and P3 components. Electrophysiological data also support the hypothesis that different neural and emotional processing magnitude and strength underlie friend and stranger effect in the context of consumer purchase. During this process, the perception of stimuli evoked P2, subsequently emotional processing and attention modulation were activated and indicated by P2 and P3. The friend dominated phenomenon can be interpreted as the result of distinctive neurocognitive and emotional processing magnitude, which suggests that psychological and emotional factors can guide consumer decision making. This study consolidates that event related potential (ERP) methodology is likely to be a more sensitive method for investigating consumer behaviors. From the perspectives of management and marketing, our findings show that the P2 and P3 components can be employed as an indicator to probe the influential factors of consumer purchase intentions. PMID:28081196

Creature comforts: personal communities, pets and the work of managing a long-term condition.

PubMed

Brooks, Helen L; Rogers, Anne; Kapadia, Dharmi; Pilgrim, Jack; Reeves, David; Vassilev, Ivaylo

2013-06-01

To explore in the context of peoples' personal social networks, the contribution that pets make to 'the work' associated with the management of long-term conditions. Mixed methods survey with nested parallel qualitative study; 300 participants were drawn from diabetes and chronic heart disease registers of General Practices across Greater Manchester in the North West of England. Notions of 'work' were used to describe the illness and everyday activities associated with chronic illness. Nineteen percent of participants identified at least one pet within their network. Pets contributed mostly to managing emotions (emotional work), to enhancing a sense of self identity (biographical work) and to a lesser extent practical tasks (everyday work). There were indicators that pets mediated relationships for people living with a long-term condition through very weak ties with others in domestic and community settings. The findings suggest that pets have unique qualities and are not simply substitutes for human relationships in long-term condition management. The study has potential implications for furthering a social contextual analysis of chronic illness, the understanding of relationships, and the meaning and the role of companion animals in long-term condition management.

Creature comforts: personal communities, pets and the work of managing a long-term condition

PubMed Central

Brooks, Helen L; Rogers, Anne; Kapadia, Dharmi; Pilgrim, Jack; Reeves, David; Vassilev, Ivaylo

2013-01-01

Objectives: To explore in the context of peoples’ personal social networks, the contribution that pets make to ‘the work’ associated with the management of long-term conditions. Method: Mixed methods survey with nested parallel qualitative study; 300 participants were drawn from diabetes and chronic heart disease registers of General Practices across Greater Manchester in the North West of England. Notions of ‘work’ were used to describe the illness and everyday activities associated with chronic illness. Results: Nineteen percent of participants identified at least one pet within their network. Pets contributed mostly to managing emotions (emotional work), to enhancing a sense of self identity (biographical work) and to a lesser extent practical tasks (everyday work). There were indicators that pets mediated relationships for people living with a long-term condition through very weak ties with others in domestic and community settings. Conclusion: The findings suggest that pets have unique qualities and are not simply substitutes for human relationships in long-term condition management. The study has potential implications for furthering a social contextual analysis of chronic illness, the understanding of relationships, and the meaning and the role of companion animals in long-term condition management. PMID:22777565

Initial Efforts toward Mission-Representative Imaging Surveys from Aerial Explorers

NASA Technical Reports Server (NTRS)

Pisanich, Greg; Plice, Laura; Ippolito, Corey; Young, Larry A.; Lau, Benton; Lee, Pascal

2004-01-01

Numerous researchers have proposed the use of robotic aerial explorers to perform scientific investigation of planetary bodies in our solar system. One of the essential tasks for any aerial explorer is to be able to perform scientifically valuable imaging surveys. The focus of this paper is to discuss the challenges implicit in, and recent observations related to, acquiring mission-representative imaging data from a small fixed-wing UAV, acting as a surrogate planetary aerial explorer. This question of successfully performing aerial explorer surveys is also tied to other topics of technical investigation, including the development of unique bio-inspired technologies.

Enduring Ties: Older Adults' Parental Role and Responsibilities.

ERIC Educational Resources Information Center

Blieszner, Rosemary; Mancini, Jay A.

1987-01-01

Used quantitative and qualitative data from 23 independent older adults to explore these salient aspects of their parenting role: change over time; current need for the role; current expectations of adult children; and rights and responsibilities of older parents. (Author/ABB)

Macrocognition in Teams and Analysis of Information Flow During the Haiti Disaster Relief

DTIC Science & Technology

2011-06-01

supplies, clean water and electricity. TIE TIE TIE Local soccer field is now a safe landing ground for helicopters. TIE TIE TIE Five flights have...TIE TIE OR’s adequate medical supplies, clean water and electricity (generator) TIE TIE TIE Local soccer field is landing pad. TIE TIE TIE 5... soccer /helo pad, TIE TIE TIE Have own ambulances for transport. TIE TIE TIE 62 Contact: "NAME" (Ground Coordinator) Haiti cell "PHONE", "E

Together Achieving More: Primary Care Team Communication and Alcohol-Related Health Care Utilization and Costs

PubMed Central

Mundt, Marlon P.; Zakletskaia, Larissa I.; Shoham, David A.; Tuan, Wen-Jan; Carayon, Pascale

2015-01-01

Background Identifying and engaging excessive alcohol users in primary care may be an effective way to improve patient health outcomes, reduce alcohol-related acute care events, and lower costs. Little is known about what structures of primary care team communication are associated with alcohol-related patient outcomes. Methods Using a sociometric survey of primary care clinic communication, this study evaluated the relation between team communication networks and alcohol-related utilization of care and costs. Between May 2013 and December 2013, a total of 155 healthcare employees at 6 primary care clinics participated in a survey on team communication. Three-level hierarchical modeling evaluated the link between connectedness within the care team and the number of alcohol-related emergency department visits, hospital days, and associated medical care costs in the past 12 months for each team’s primary care patient panel. Results Teams (n=31) whose RNs displayed more strong (at least daily) face-to-face ties and strong (at least daily) electronic communication ties had 10% fewer alcohol-related hospital days (RR=0.90; 95% CI: 0.84, 0.97). Furthermore, in an average team size of 19, each additional team member with strong interaction ties across the whole team was associated with $1030 (95% CI: −$1819, −$241) lower alcohol-related patient health care costs per 1000 team patients in the past 12 months. Conversely, teams whose primary care practitioner had more strong face-to-face communication ties and more weak (weekly or several times a week) electronic communication ties had 12% more alcohol-related hospital days (RR=1.12; 95: CI: 1.03, 1.23) and $1428 (95% CI: $378, $2478) higher alcohol-related healthcare costs per 1000 patients in the past 12 months. The analyses controlled for patient age, gender, insurance, and co-morbidity diagnoses. Conclusions Excessive alcohol-using patients may fair better if cared for by teams whose face-to-face and electronic communication networks include more team members and whose communication to the PCP has been streamlined to fewer team members. PMID:26350957

Together Achieving More: Primary Care Team Communication and Alcohol-Related Healthcare Utilization and Costs.

PubMed

Mundt, Marlon P; Zakletskaia, Larissa I; Shoham, David A; Tuan, Wen-Jan; Carayon, Pascale

2015-10-01

Identifying and engaging excessive alcohol users in primary care may be an effective way to improve patient health outcomes, reduce alcohol-related acute care events, and lower costs. Little is known about what structures of primary care team communication are associated with alcohol-related patient outcomes. Using a sociometric survey of primary care clinic communication, this study evaluated the relation between team communication networks and alcohol-related utilization of care and costs. Between May 2013 and December 2013, a total of 155 healthcare employees at 6 primary care clinics participated in a survey on team communication. Three-level hierarchical modeling evaluated the link between connectedness within the care team and the number of alcohol-related emergency department visits, hospital days, and associated medical care costs in the past 12 months for each team's primary care patient panel. Teams (n = 31) whose registered nurses displayed more strong (at least daily) face-to-face ties and strong (at least daily) electronic communication ties had 10% fewer alcohol-related hospital days (rate ratio [RR] = 0.90; 95% confidence interval [CI]: 0.84, 0.97). Furthermore, in an average team size of 19, each additional team member with strong interaction ties across the whole team was associated with $1,030 (95% CI: -$1,819, -$241) lower alcohol-related patient healthcare costs per 1,000 team patients in the past 12 months. Conversely, teams whose primary care practitioner (PCP) had more strong face-to-face communication ties and more weak (weekly or several times a week) electronic communication ties had 12% more alcohol-related hospital days (RR = 1.12; 95% CI: 1.03, 1.23) and $1,428 (95% CI: $378, $2,478) higher alcohol-related healthcare costs per 1,000 patients in the past 12 months. The analyses controlled for patient age, gender, insurance, and comorbidity diagnoses. Excessive alcohol-using patients may fair better if cared for by teams whose face-to-face and electronic communication networks include more team members and whose communication to the PCP has been streamlined to fewer team members. Copyright © 2015 by the Research Society on Alcoholism.

Icebreaker: The Evaluation

ERIC Educational Resources Information Center

Peerbhoy, Denise; Bourke, Cathriona

2007-01-01

Objective: To document young people's and teachers' responses to "Icebreaker", a Theatre in Education (TIE) performance exploring themes of sexual health and relationships, in relation to "Healthy Arts"' objectives. Design: Data reported here were part of a wider evaluation of a government funded scheme. Setting: Data was…

Federal funding of rail rehabilitation : a review of alternative approaches

DOT National Transportation Integrated Search

1975-09-01

This study explores the proposed mechanisms for injecting federal funds into the rehabilitation of the fixed plant of U.S. railroads--that is, the roadbed, ballast, ties, signaling systems, yards and terminals that make up the physical rail system. T...

The Catholic University.

ERIC Educational Resources Information Center

Danneels, Godfried

2001-01-01

Explores the nature and mission of the Catholic university, addressing a wide range of topics, including the search for truth, the full depth of humanity, institutional autonomy, harmonization of knowledge, ties to the church, cross-cultural dialogue, evangelization, academic freedom, pluralism, the Catholic sensibility, and leadership. (EV)

Evolutionary dynamics on any population structure

NASA Astrophysics Data System (ADS)

Allen, Benjamin; Lippner, Gabor; Chen, Yu-Ting; Fotouhi, Babak; Momeni, Naghmeh; Yau, Shing-Tung; Nowak, Martin A.

2017-03-01

Evolution occurs in populations of reproducing individuals. The structure of a population can affect which traits evolve. Understanding evolutionary game dynamics in structured populations remains difficult. Mathematical results are known for special structures in which all individuals have the same number of neighbours. The general case, in which the number of neighbours can vary, has remained open. For arbitrary selection intensity, the problem is in a computational complexity class that suggests there is no efficient algorithm. Whether a simple solution for weak selection exists has remained unanswered. Here we provide a solution for weak selection that applies to any graph or network. Our method relies on calculating the coalescence times of random walks. We evaluate large numbers of diverse population structures for their propensity to favour cooperation. We study how small changes in population structure—graph surgery—affect evolutionary outcomes. We find that cooperation flourishes most in societies that are based on strong pairwise ties.

The fraternal WIMP miracle

DOE PAGES

Craig, Nathaniel; Katz, Andrey

2015-10-27

We identify and analyze thermal dark matter candidates in the fraternal twin Higgs model and its generalizations. The relic abundance of fraternal twin dark matter is set by twin weak interactions, with a scale tightly tied to the weak scale of the Standard Model by naturalness considerations. As such, the dark matter candidates benefit from a "fraternal WIMP miracle'', reproducing the observed dark matter abundance for dark matter masses between 50 and 150 GeV . However, the couplings dominantly responsible for dark matter annihilation do not lead to interactions with the visible sector. The direct detection rate is instead setmore » via fermionic Higgs portal interactions, which are likewise constrained by naturalness considerations but parametrically weaker than those leading to dark matter annihilation. Finally, the predicted direct detection cross section is close to current LUX bounds and presents an opportunity for the next generation of direct detection experiments.« less

The dynamic evolution of social ties and user-generated content: a case study on a Douban group

NASA Astrophysics Data System (ADS)

Shan, Siqing; Ren, Jie; Li, Cangyan

2017-11-01

As platforms based on user-generated content (UGC), social media platforms emphasise the social ties between users and user participation, which promote the communication and propagation of ideas and help to build and maintain relationships. However, many researchers have studied only predefined social networks, such as academic social networks. We believe that there are certain characteristics associated with the network's UGC worth evaluating. We conducted research in communities in which content attracts discussion and new members and examined the evolution patterns of social and content networks in a topic-oriented Douban group. Datasets of user and content information in communities of interest were collected through web crawler software. Networks based on social and content ties were constructed and analysed. We chose scale, density, centrality, average path length and cluster coefficient as measures for exploring the evolution and correlation of both types of networks. These findings are valuable for social media marketing and helpful in directing and controlling public opinion.

The influence of body weight on social network ties among adolescents.

PubMed

Ali, Mir M; Amialchuk, Aliaksandr; Rizzo, John A

2012-01-01

Evidence of negative stereotypes, prejudice and discrimination towards obese individuals has been widely documented. However, the effect of a larger body size on social network ties or friendship formations is less well understood. In this paper, we explore the extent to which higher body weight results in social marginalization of adolescents. Using data from a nationally representative sample of adolescents, we estimate endogeneity-corrected models including school-level fixed effects that account for bi-directionality and unobserved confounders to ascertain the effect of body weight on social network ties. We find that obese adolescents have fewer friends and are less socially integrated than their non-obese counterparts. We also find that such penalties in friendship networks are present among whites but not African-Americans or Hispanics, with the largest effect among white females. These results are robust to common environmental influences at the school-level and to controls for preferences, risk attitudes, low self-esteem and objective measures of physical attractiveness. Published by Elsevier B.V.

Balancing the cost of leaving with the cost of living: drivers of long-term retention of health workers: an explorative study in three rural districts in Eastern Uganda

PubMed Central

Namusoke Kiwanuka, Suzanne; Akulume, Martha; Tetui, Moses; Muhumuza Kananura, Rornald; Bua, John; Ekirapa-Kiracho, Elizabeth

2017-01-01

ABSTRACT Background: Health worker retention in rural and underserved areas remains a persisting problem in many low and middle income countries, and this directly affects the quality of health services offered. Objective: This paper explores the drivers of long-term retention and describes health worker coping mechanisms in rural Uganda. Methods: A descriptive qualitative study explored the factors that motivated health workers to stay, in three rural districts of Uganda: Kamuli, Pallisa, and Kibuku. In-depth interviews conducted among health workers who have been retained for at least 10 years explored factors motivating the health workers to stay within the district, opportunities, and the benefits of staying. Results: Twenty-one health workers participated. Ten of them male and 11 female with the age range of 33–51 years. The mean duration of stay among the participants was 13, 15, and 26 years for Kamuli, Kibuku, and Pallisa respectively. Long-term retention was related to personal factors, such as having family ties, community ties, and opportunities to invest. The decentralization policy and pension benefits also kept workers in place. Opportunities for promotion or leadership motivated long stay only if they came with financial benefits. Workload reportedly increased over the years, but staffing and emoluments had not increased. Multiple job, family support, and community support helped health workers cope with the costs of living, and holding a secure pensionable government job was valued more highly than seeking uncertain job opportunities elsewhere. Conclusion: The interplay between the costs of leaving and the benefit of staying is demonstrated. Family proximity, community ties, job security, and pension enhance staying, while higher costs of living and an unpredictable employment market make leaving risky. Health workers should be able to access investment opportunities in order to cope with inadequate remuneration. Promotions and leadership opportunities only motivate if accompanied by financial benefits. PMID:28838292

Network effects on scientific collaborations.

PubMed

Uddin, Shahadat; Hossain, Liaquat; Rasmussen, Kim

2013-01-01

The analysis of co-authorship network aims at exploring the impact of network structure on the outcome of scientific collaborations and research publications. However, little is known about what network properties are associated with authors who have increased number of joint publications and are being cited highly. Measures of social network analysis, for example network centrality and tie strength, have been utilized extensively in current co-authorship literature to explore different behavioural patterns of co-authorship networks. Using three SNA measures (i.e., degree centrality, closeness centrality and betweenness centrality), we explore scientific collaboration networks to understand factors influencing performance (i.e., citation count) and formation (tie strength between authors) of such networks. A citation count is the number of times an article is cited by other articles. We use co-authorship dataset of the research field of 'steel structure' for the year 2005 to 2009. To measure the strength of scientific collaboration between two authors, we consider the number of articles co-authored by them. In this study, we examine how citation count of a scientific publication is influenced by different centrality measures of its co-author(s) in a co-authorship network. We further analyze the impact of the network positions of authors on the strength of their scientific collaborations. We use both correlation and regression methods for data analysis leading to statistical validation. We identify that citation count of a research article is positively correlated with the degree centrality and betweenness centrality values of its co-author(s). Also, we reveal that degree centrality and betweenness centrality values of authors in a co-authorship network are positively correlated with the strength of their scientific collaborations. Authors' network positions in co-authorship networks influence the performance (i.e., citation count) and formation (i.e., tie strength) of scientific collaborations.

Heard it through the grapevine: indirect networks and employee creativity.

PubMed

Hirst, Giles; Van Knippenberg, Daan; Zhou, Jing; Quintane, Eric; Zhu, Cherrie

2015-03-01

Social networks can be important sources of information and insights that may spark employee creativity. The cross-fertilization of ideas depends not just on access to information and insights through one's direct network-the people one actually interacts with--but at least as much on access to the indirect network one's direct ties connect one to (i.e., people one does not interact with directly, but with whom one's direct ties interact). We propose that the reach efficiency of this indirect network--its nonredundancy in terms of interconnections--is positively related to individual creativity. To help specify the boundaries of this positive influence of the indirect network, we also explore how many steps removed the indirect network still adds to creativity. In addition, we propose that the efficiency (nonredundancy) of one's direct network is important here, because more efficient direct networks give one access to indirect networks with greater reach efficiency. Our hypotheses were supported in a multilevel analysis of multisource survey data from 223 sales representatives nested within 11 divisions of a Chinese pharmaceutical company. This analysis also showed that the creative benefits of reach efficiency were evident for 3 and 4 degrees of separation but were greatest for indirect ties that depend only on one's direct ties. PsycINFO Database Record (c) 2015 APA, all rights reserved.

The DNA of Materials

ERIC Educational Resources Information Center

Abdul-Razzaq, Wathiq N.; Bushey, Ryan K.

2009-01-01

Introductory physics labs provide many challenging yet applicable experiments and concepts to the many fields of engineering. One such lab has been developed at West Virginia University that explores resistivities of several different materials and ties this concept into electrical engineering practices and standards. Many students do not realize…

Negotiating Inequality among Adult Siblings: Two Case Studies

ERIC Educational Resources Information Center

Connidis, Ingrid Arnet

2007-01-01

Qualitative instrumental case study analysis of adult siblings from 2 families explores how socioeconomic inequality among them affects their relationships to one another. Eight middle-aged siblings' observations of childhood, parental expectations, work and family history, lifestyle, and current sibling ties indicate that childhood…

Tie Points Extraction for SAR Images Based on Differential Constraints

NASA Astrophysics Data System (ADS)

Xiong, X.; Jin, G.; Xu, Q.; Zhang, H.

2018-04-01

Automatically extracting tie points (TPs) on large-size synthetic aperture radar (SAR) images is still challenging because the efficiency and correct ratio of the image matching need to be improved. This paper proposes an automatic TPs extraction method based on differential constraints for large-size SAR images obtained from approximately parallel tracks, between which the relative geometric distortions are small in azimuth direction and large in range direction. Image pyramids are built firstly, and then corresponding layers of pyramids are matched from the top to the bottom. In the process, the similarity is measured by the normalized cross correlation (NCC) algorithm, which is calculated from a rectangular window with the long side parallel to the azimuth direction. False matches are removed by the differential constrained random sample consensus (DC-RANSAC) algorithm, which appends strong constraints in azimuth direction and weak constraints in range direction. Matching points in the lower pyramid images are predicted with the local bilinear transformation model in range direction. Experiments performed on ENVISAT ASAR and Chinese airborne SAR images validated the efficiency, correct ratio and accuracy of the proposed method.

Local Groups Online: Political Learning and Participation

NASA Astrophysics Data System (ADS)

Kavanaugh, Andrea; Zin, Thanthan; Schmitz, Joseph; Rosson, Mary Beth; Kim, B. Joon; Carroll, John M.

Voluntary associations serve crucial roles in local communities and within our larger democratic society. They aggregate shared interests, collective will, and cultivate civic competencies that nurture democratic participation. People active in multiple local groups frequently act as opinion leaders and create “weak” social ties across groups. In Blacksburg and surrounding Montgomery County, Virginia, the Blacksburg Electronic Village (BEV) community computer network has helped to foster nearly universal Internet penetration. Set in this dense Internet context, the present study investigated whether and how personal affiliation with local groups enhanced political participation in this high information and communication technology environment. This paper presents findings from longitudinal survey data which indicate that as individuals’ uses of information technology within local formal groups increase over time, so do their levels and types of involvement in the group. Furthermore, these increases most often appear among people who serve as opinion leaders and maintain weak social ties in their communities. Individuals’ changes in community participation, interests and activities, and Internet use suggest ways in which group members act upon political motivations and interests across various group types.

The association between social capital measures and self-reported health among Muslim majority nations.

PubMed

Kim, Harris Hyun-soo

2014-10-01

Much evidence suggests that social capital (e.g. networks, trust, organizational memberships) has a significant effect on self-reported health. Previous research, however, has focused primarily on Western countries. The current research seeks to remedy this problem by investigating the association between multiple social capital indicators and subjective health in a novel empirical setting. The data come from the Comparative Values Survey of Islamic Countries (1999-2006) which consists of probabilistic samples from Muslim majority nations. Three-way multilevel analysis is used to examine the social determinants of health. Statistical results from hierarchical linear modeling shows that frequent contact with strong and intermediate ties (i.e. family members and friends, respectively) is significant, while interaction with weak ties (coworkers) has no association. General trust and trust in the central government are also significantly related to subjective health, as is trust in religious authority, albeit in an inverse way. This study calls for a more contingent view of the relationship between social capital and self-reported health. Future research needs to take this into consideration in hypothesizing and testing the potential health benefits of social capital.

Competition between Homophily and Information Entropy Maximization in Social Networks

PubMed Central

Zhao, Jichang; Liang, Xiao; Xu, Ke

2015-01-01

In social networks, it is conventionally thought that two individuals with more overlapped friends tend to establish a new friendship, which could be stated as homophily breeding new connections. While the recent hypothesis of maximum information entropy is presented as the possible origin of effective navigation in small-world networks. We find there exists a competition between information entropy maximization and homophily in local structure through both theoretical and experimental analysis. This competition suggests that a newly built relationship between two individuals with more common friends would lead to less information entropy gain for them. We demonstrate that in the evolution of the social network, both of the two assumptions coexist. The rule of maximum information entropy produces weak ties in the network, while the law of homophily makes the network highly clustered locally and the individuals would obtain strong and trust ties. A toy model is also presented to demonstrate the competition and evaluate the roles of different rules in the evolution of real networks. Our findings could shed light on the social network modeling from a new perspective. PMID:26334994

Integrating visualization and interaction research to improve scientific workflows.

PubMed

Keefe, Daniel F

2010-01-01

Scientific-visualization research is, nearly by necessity, interdisciplinary. In addition to their collaborators in application domains (for example, cell biology), researchers regularly build on close ties with disciplines related to visualization, such as graphics, human-computer interaction, and cognitive science. One of these ties is the connection between visualization and interaction research. This isn't a new direction for scientific visualization (see the "Early Connections" sidebar). However, momentum recently seems to be increasing toward integrating visualization research (for example, effective visual presentation of data) with interaction research (for example, innovative interactive techniques that facilitate manipulating and exploring data). We see evidence of this trend in several places, including the visualization literature and conferences.

Alcohol Use among Adolescent Youth: The Role of Friendship Networks and Family Factors in Multiple School Studies

PubMed Central

Wang, Cheng; Hipp, John R.; Butts, Carter T.; Jose, Rupa; Lakon, Cynthia M.

2015-01-01

To explore the co-evolution of friendship tie choice and alcohol use behavior among 1,284 adolescents from 12 small schools and 976 adolescents from one big school sampled in the National Longitudinal Study of Adolescent to Adult Health (AddHealth), we apply a Stochastic Actor-Based (SAB) approach implemented in the R-based Simulation Investigation for Empirical Network Analysis (RSiena) package. Our results indicate the salience of both peer selection and peer influence effects for friendship tie choice and adolescent drinking behavior. Concurrently, the main effect models indicate that parental monitoring and the parental home drinking environment affected adolescent alcohol use in the small school sample, and that parental home drinking environment affected adolescent drinking in the large school sample. In the small school sample, we detect an interaction between the parental home drinking environment and choosing friends that drink as they multiplicatively affect friendship tie choice. Our findings suggest that future research should investigate the synergistic effects of both peer and parental influences for adolescent friendship tie choices and drinking behavior. And given the tendency of adolescents to form ties with their friends' friends, and the evidence of local hierarchy in these networks, popular youth who do not drink may be uniquely positioned and uniquely salient as the highest rank of the hierarchy to cause anti-drinking peer influences to diffuse down the social hierarchy to less popular youth. As such, future interventions should harness prosocial peer influences simultaneously with strategies to increase parental support and monitoring among parents to promote affiliation with prosocial peers. PMID:25756364

Swedish and South African nursing students' descriptions of family.

PubMed

Erlingsson, Christen; Brysiewicz, Petra

2015-05-01

The purpose of this study was to compare and contrast descriptions of "family" amongst Swedish and South African university nursing students. This qualitative inquiry, using convenience sampling, explored how 232 undergraduate and postgraduate nursing students responded to a two-query, open-response questionnaire designed to elicit a definition of family and a description of who students considered to be members of their own families. Free-text responses were analyzed using manifest and qualitative content analysis. Five categories emerged from the data: Ties of Kinship, Ties of Love, Ties of Influence, Ties of Everyday Life, and Tied by Slipknots. Analysis clarified that students' responses from both countries were addressing the same issues and as such were in general very similar. Contrasting Swedish and South African responses, a noticeable difference in proportions of responses coded into each category was evident. Three conceptualizations of family are offered: for the total sample, Swedish sample, and South African sample. The study provides data on students' conceptualization of family usable in family research, nursing education, and practice as a basis for comparison, and as a starting point for discussions on the nursing of families, not only in South Africa and Sweden, but also in broader international contexts. Because understanding family is important for healthcare providers in their everyday work, awareness about what is meant by family can assist nurses through increasing understanding of the complexities surrounding this issue and encouraging cultural sensitivity and openness to patients' and families' views about who is a family member. © 2015 Sigma Theta Tau International.

An Ecological Critique of Education

ERIC Educational Resources Information Center

LeFay, Raven

2006-01-01

This discussion is a critical analysis of mainstream Western education. It explores the system's historical ties with industrial civilization, and considers how both have emerged from a mechanistic worldview, and how the education system has evolved to serve the interests of capitalism and colonialism. The corporate takeover of the education…

Scholars, Intellectuals, and Bricoleurs

ERIC Educational Resources Information Center

Papson, Stephen

2014-01-01

This essay explores three orientations to knowledge: the scholar, the intellectual, and the bricoleur. It argues that although the scholar and the intellectual are tied closely to the Liberal Arts and Humanities and dominate academic public relations discourse, both students and faculty increasingly use the practice of bricolage to gather and…

Exploring Indigenous Identities of Urban American Indian Youth of the Southwest

ERIC Educational Resources Information Center

Kulis, Stephen; Wagaman, M. Alex; Tso, Crescentia; Brown, Eddie F.

2013-01-01

This study examined the indigenous identities of urban American Indian youth using measures related to three theoretical dimensions of Markstrom's identity model: identification (tribal and ethnic heritage), connection (reservation ties), and involvement in traditional cultural practices and spirituality. Data came from self-administered…

Investigating the Educational Needs of Black Girls: A Research Note.

ERIC Educational Resources Information Center

Murray, Saundra Rice

1984-01-01

Describes how evaluative studies of social and educational programs can be useful in (1) providing data about Black girls and their needs, (2) examining Black girls' experiences that have not been explored in basic research, and (3) tying data to matters of future practice. (KH)

What Should Gerontology Learn from Health Education Accreditation?

ERIC Educational Resources Information Center

Bradley, Dana Burr; Fitzgerald, Kelly

2012-01-01

Quality assurance and accreditation are closely tied together. This article documents the work toward a unified and comprehensive national accreditation program in health education. By exploring the accreditation journey of another discipline, the field of gerontology should learn valuable lessons. These include an attention to inclusivity, a…

CASE STUDY 6.26: UNSUCCESSFUL TOXICITY IDENTIFICATION AND EVALUATIONS MANIPULATIONS: SEAWATER BUFFERS AND STERILIZATION METHODS

EPA Science Inventory

This paper summarizes several unsuccessful attempts to develop Toxicity Identification and Evaluation (TIE) manipulations for aqueous samples during the first 5 years of our research. The first part of the paper explores irradiation as a sterilization technique to discern if sam...

How to Desire Differently: Home Education as a Heterotopia

ERIC Educational Resources Information Center

Pattison, Harriet

2015-01-01

This article explores the co-existence of, and relationship between, alternative education in the form of home education and mainstream schooling. Home education is conceptually subordinate to schooling, relying on schooling for its status as alternative, but also being tied to schooling through the dominant discourse that forms our understandings…

The Contemporary City as Backbone: Museum Rotterdam Meets the Challenge

ERIC Educational Resources Information Center

van de Laar, Paul Th.

2013-01-01

Changes at Museum Rotterdam illustrate how history museums can rethink their relationship to history and community. Recognizing that its residents are increasingly transnational, without ties to the Rotterdam of the past, Museum Rotterdam is using the tools of urban anthropologists to involve residents in exploring contemporary heritage. Museum…

Exploring the Meta-Pragmatic Realm in English Language Teaching

ERIC Educational Resources Information Center

McConachy, Troy

2013-01-01

As the speakership of English worldwide continues to grow, English language teachers are required to devise ways to prepare their learners for communicating successfully across cultures. As pragmatics is particularly tied up with culture, the ways in which individuals from different cultures will orient to pragmatic phenomena in their interaction…

The Supreme Court, Religion and the Temper of the Times.

ERIC Educational Resources Information Center

Hunt, Thomas C.

1986-01-01

Explores ties between contemporary social issues and Supreme Court decisions during four periods. Considers Meyer v. Nebraska (1923), Pierce v. Society of Sisters (1925), Central School District v. Allen (1968), Lemon v. Kurtzman (1971), Wallace v. Jaffree (1985), Aguilar v. Felton (1985), and other decisions. (DMM)

Challenging Neoliberalism and Multicultural Love in Art Therapy

ERIC Educational Resources Information Center

Gipson, Leah

2017-01-01

In this article, I examine the ties between neoliberalism and multiculturalism in art therapy in the United States. I explore the neoliberal privatization of society as an influence of individualistic norms in the profession. I explain my analysis of multiculturalism using the 1954 film "Magnificent Obsession" and introduce the concept…

Detail of interior of compressed air chamber showing top of ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Detail of interior of compressed air chamber showing top of working chamber and tie rods that strengthen the outer shell plates of the compression chamber. - Sub Marine Explorer, Located along the beach of Isla San Telmo, Pearl Islands, Isla San Telmo, Former Panama Canal Zone, CZ

Community Size, Community Attachment and Newspaper Readership.

ERIC Educational Resources Information Center

Stephens, Lowndes F.

Residents in several states and communities ranging in size from farms to inner cities of more than 500,000 people were surveyed to further explore the strong relationship between community ties and newspaper readership indicated by results of a previous study sponsored by the American Newspaper Publishers Association. The findings revealed that…

Student Projects as a Funding Source

ERIC Educational Resources Information Center

Henson, Kerry L.

2010-01-01

Prompted by restricted funding for a lab which supported student software development work on real-world projects, a contribution program was established to facilitate monetary support from the external clients. The paper explores the relationships between instructor, students and client and how a funding component can affect these ties.…

Cracking the Egg: The South Carolina Digital Library's New Perspective

ERIC Educational Resources Information Center

Vinson, Christopher G.; Boyd, Kate Foster

2008-01-01

This article explores the historical foundations of the South Carolina Digital Library, a collaborative statewide program that ties together academic special collections and archives, public libraries, state government archives, and other cultural resource institutions in an effort to provide the state with a comprehensive database of online…

Selected topics in robotics for space exploration

NASA Technical Reports Server (NTRS)

Montgomery, Raymond C. (Editor); Kaufman, Howard (Editor)

1993-01-01

Papers and abstracts included represent both formal presentations and experimental demonstrations at the Workshop on Selected Topics in Robotics for Space Exploration which took place at NASA Langley Research Center, 17-18 March 1993. The workshop was cosponsored by the Guidance, Navigation, and Control Technical Committee of the NASA Langley Research Center and the Center for Intelligent Robotic Systems for Space Exploration (CIRSSE) at RPI, Troy, NY. Participation was from industry, government, and other universities with close ties to either Langley Research Center or to CIRSSE. The presentations were very broad in scope with attention given to space assembly, space exploration, flexible structure control, and telerobotics.

Geometric Stitching Method for Double Cameras with Weak Convergence Geometry

NASA Astrophysics Data System (ADS)

Zhou, N.; He, H.; Bao, Y.; Yue, C.; Xing, K.; Cao, S.

2017-05-01

In this paper, a new geometric stitching method is proposed which utilizes digital elevation model (DEM)-aided block adjustment to solve relative orientation parameters for dual-camera with weak convergence geometry. A rational function model (RFM) with affine transformation is chosen as the relative orientation model. To deal with the weak geometry, a reference DEM is used in this method as an additional constraint in the block adjustment, which only calculates the planimetry coordinates of tie points (TPs). After that we can use the obtained affine transform coefficients to generate virtual grid, and update rational polynomial coefficients (RPCs) to complete the geometric stitching. Our proposed method was tested on GaoFen-2(GF-2) dual-camera panchromatic (PAN) images. The test results show that the proposed method can achieve an accuracy of better than 0.5 pixel in planimetry and have a seamless visual effect. For regions with small relief, when global DEM with 1 km grid, SRTM with 90 m grid and ASTER GDEM V2 with 30 m grid replaced DEM with 1m grid as elevation constraint it is almost no loss of accuracy. The test results proved the effectiveness and feasibility of the stitching method.

Anthropology, HIV and contingent identities.

PubMed

Gatter, P N

1995-12-01

The paper explores the relationship between social identity and HIV/AIDS, with special reference to gay men in Britain. This relationship was first seen as significant since it might have a bearing on the spread of HIV in the population. Three major forms of commentary have emerged on the issue: (i) basic research into the relationship between sexual identities and behaviours; (ii) applied research on how to convert the findings from (i) into health promotional materials, and (iii) discourse from within the politically gay community on what HIV/AIDS means for gay people. These different forms of commentary arise from a diverse range of voices, within and outside academia. The paper draws comparison between different disciplinary approaches to questions of identity and HIV/AIDS, in terms of their relative strengths and weaknesses (for example, contrasting psychology with anthropology). An ethnography of a day centre for people living with HIV/AIDS is used to illustrate the need to understand identity from a processual perspective, so that both individual and collective identities are seen as emerging from specific historical circumstances and struggles. A dialogic approach to understanding identity, tied to qualitative empirical research, is suggested as necessary to understanding how different forms of identity engage with HIV/AIDS (gender, ethnicity, age, sexual orientation), and how the identities of individuals and groups are always complex, shifting mosaics.

Strong, female and Black: Stereotypes of African Caribbean women's body shape and their effects on clinical encounters.

PubMed

Andrews, Nicole; Greenfield, Sheila; Drever, Will; Redwood, Sabi

2017-03-01

The aim of this article is to explore how tendencies to stereotype minority ethnic groups intersect with lay discourses about them in ways that can reproduce cultural prejudices and reinforce inequalities in access to services and health outcomes. Drawing upon Black feminist and cultural studies literature, we present a theoretical examination, the stereotypes of the Black woman as 'mammy' and 'matriarch'. We suggest that the influence of these two images is central to understanding the normalisation of the larger Black female body within African Caribbean communities. This representation of excess weight contradicts mainstream negative discourses of large bodies that view it as a form of moral weakness. Seeking to stimulate reflection on how unacknowledged stereotypes may shape clinical encounters, we propose that for Black women, it is the perception of strength, tied into these racial images of 'mammy' and 'matriarch' which may influence when or how health services or advice are both sought by them and offered to them. This has particular significance in relation to how body weight and weight management are/are not talked about in primary care-based interactions and what support Black women are/are not offered. We argue that unintentional bias can have tangible impacts and health outcomes for Black women and possibly other minority ethnic groups.

Social inequalities in oral health and in use of oral health care services among adolescents in Uganda.

PubMed

Okullo, I; Astrøm, A N; Haugejorden, O

2004-09-01

The aim of this study was to describe clinical and self-perceived indicators of oral health status and the use of oral health care services by social and demographic characteristics. In 2001, a cross-sectional random sample survey was conducted in urban and rural settings in Uganda (Kampala and Lira, respectively), and 1146 secondary school students with a mean age of 15.8 years completed questionnaires in school. Dental caries was recorded by one examiner on a random subsample of 372 students. Logistic regression analyses revealed that being an urban resident was associated with higher odds for having dental caries (dmft > 0), seeking care because of toothache (delayed treatment demand) and being dissatisfied with one's own oral health status [adjusted odds ratio (OR) = 1.5-2.1]. Being an urban resident was associated with lower odds for oral health care attendance generally and for having missing teeth in particular (adjusted OR = 0.6-0.4). Students who had parents with a higher education and those with weak social ties were, respectively, less and more likely to be dissatisfied with their oral health status. As compared to caries-free participants, the odds for being dissatisfied with oral health and delayed treatment demand increased significantly with an increasing dmft score (adjusted OR = 2.1-3.2). Urban students were most likely to have a dmft > 0 and to rate their oral health status negatively. Having received dental care and the prevalence of missing teeth, and delayed treatment demand were, respectively, most and least prevalent among rural students. Dental caries at different diagnostic cut-off points and weak social ties affected self-reported oral health negatively, independently of social and demographic characteristics. Copyright 2004 BSPD and IAPD

Assessment of Neighborhood Context in a Nationally Representative Study

PubMed Central

Cagney, Kathleen A.

2014-01-01

Objectives. This paper introduces new measures of neighborhood context that are included in the second wave of the National Social Life, Health, and Aging Project (NSHAP). We describe the use of field interviewer ratings of respondents’ neighborhood conditions, as well as the adaptation of existing measures for the assessment of neighborhood social context among urban and nonurban older adults. Method. We construct scales of neighborhood problems, neighborhood social cohesion, neighborhood social ties, and perceived neighborhood danger, and assess their reliability and validity. We then calculate descriptive statistics for measures of neighborhood context across respondent age, gender, and racial/ethnic background, and across low-, moderate-, and high-density residential blocks. Results. We find that older women report greater neighborhood cohesion and more neighborhood ties than older men, but women also perceive more neighborhood danger. Black and Hispanic older adults reside in neighborhoods with more problems, lower cohesion, fewer social ties, and greater perceived danger. Neighborhood characteristics also vary across residential densities. Neighborhood problems and perceived danger increase with block-level density, but neighborhood social cohesion and social ties were lowest among residents of moderate-density blocks. Discussion. The inclusion of neighborhood context measures in the second wave of NSHAP provides a unique opportunity to explore associations among neighborhood context, social connectedness, and indicators of health and function among older adults. We discuss limitations of the measures and provide recommendations for their use. PMID:24875376

Relationships with former stepgrandparents after remarriage dissolution.

PubMed

Sanner, Caroline; Coleman, Marilyn; Ganong, Lawrence

2018-03-01

Increases in stepfamily formation and longevity suggest that more children have stepgrandparent relationships than ever before. Because remarriages end in divorce more often than first marriages, many children experience the involuntary dissolution of stepgrandparent ties. Little is known about stepgrandparent relationships in general, and even less is known about how these relationships are affected by remarriage dissolution. Guided by symbolic interaction theory, the purpose of this study was to understand how stepgrandchildren make sense of their relationships with former stepgrandparents. We explored their perceptions of why relationships were or were not maintained and the impact of continued or dissolved ties on their personal well-being. Former stepgrandchildren (N = 29) aged 18 to 37 were interviewed about their former stepgrandparents. The quality and continuity of these relationships were contingent on stepgrandchildren's relationships with former stepparents, biological parents' relationships with former stepgrandparents, and efforts by former stepgrandparents to remain involved. Losing ties with former stepgrandparents was upsetting, especially when relationships with biological grandparents were not close. Individuals who maintained relationships with former stepgrandparents benefitted from continued access to valuable resources (e.g., positive role models, additional sources of love and support). Our findings have important implications for clinicians' and researchers' understanding of the effects of remarriage dissolution on children as well as the intergenerational efforts that may be critical for preserving meaningful stepfamily ties. (PsycINFO Database Record (c) 2018 APA, all rights reserved).

Empowerment of Women through Education in Twenty First Century

ERIC Educational Resources Information Center

Moradi Sheykhjan, Tohid; Rajeswari, K.; Jabari, Kamran

2014-01-01

This article explores theoretical and practical issues related to the impact of women's education in their empowerment. The development of women's education is discussed in this study. As women's education has become one of the key development objectives in the recent decades, the concept of empowerment has been tied to the range of activities…

Culture Clash or Ties That Bind? What Australian Academics Think of Professional Staff

ERIC Educational Resources Information Center

Gray, Stephen

2015-01-01

This paper uses a framework analysis to explore the opinions a cohort of Australian academic staff hold towards professional staff. Five indicative themes were identified from the extant literature on university professional staff: the professional other; managerialism; an expensive bureaucracy; complementary agendas; and the third space and…

Two Generations: Partners in Prevention. Youth in Action. Bulletin, Number 5.

ERIC Educational Resources Information Center

Department of Justice, Washington, DC. Office of Juvenile Justice and Delinquency Prevention.

Young and old joining together in intergenerational projects where they share their insights, skills, and experiences can strengthen community ties and improve the well-being of all participants. This bulletin explores ways both younger and older members of a community can work together on a crime prevention initiative. Such a partnership in…

Tied to the Common Core: Exploring the Characteristics of Reform Advice Relationships of Educational Leaders

ERIC Educational Resources Information Center

Liou, Yi-Hwa

2016-01-01

Purpose: Researchers and scholars have called for greater attention to collaboration among and between educational leaders in districtwide reform. This work underlines the important social aspect of such collaboration and further investigates the type of professional interaction among/between district and school leaders particularly around the…

Why So Difficult? Exploring Negative Relationships between Educational Leaders: The Role of Trust, Climate, and Efficacy

ERIC Educational Resources Information Center

Daly, Alan J.; Moolenaar, Nienke M.; Liou, Yi-Hwa; Tuytens, Melissa; del Fresno, Miguel

2015-01-01

Recent work suggests the importance of collaboration among district-office and school leaders. Most studies examine prosocial relationships, but negative social ties, which may be more consequential, are rarely examined. We collected survey data from 78 educational leaders on perceptions of culture and negative relationships and used…

Intra-Nationalization of Higher Education: The Hong Kong Case

ERIC Educational Resources Information Center

Chao, Roger Y.

2012-01-01

This paper explores the internationalization of higher education initiatives of Hong Kong, being one of the Special Administrative Regions (SAR) of China, within the context of the Chinese Mainland-Hong Kong (CM-HK) relations. Historical, social, economic, and political ties between Hong Kong and the Mainland of China, their economic and political…

Policing Alcohol and Related Crimes on Campus

ERIC Educational Resources Information Center

Allen, Andrea N.

2013-01-01

Research shows that college students drink alcohol frequently and heavily. This can compromise their health and well-being. Student drinking is also tied to crime. While prior work explores the nature and extent of crimes involving alcohol on campus, to date no study has examined how police handle these incidents or crime generally. This study…

The Elephant in the Schoolhouse: The Role of Propinquity in School Staff Interactions about Teaching

ERIC Educational Resources Information Center

Spillane, James P.; Shirrell, Matthew; Sweet, Tracy M.

2017-01-01

Although the physical arrangement of workspaces can both constrain and enable interactions among organizational members, sociological research in education has not extensively examined the role of physical proximity in determining work-related social ties among school staff. Using social network analysis, this article explores the relationship…

Profiling Students Who Take Online Courses Using Data Mining Methods

ERIC Educational Resources Information Center

Yu, Chong Ho; Digangi, Samuel; Jannasch-Pennell, Angel Kay; Kaprolet, Charles

2008-01-01

The efficacy of online learning programs is tied to the suitability of the program in relation to the target audience. Based on the dataset that provides information on student enrollment, academic performance, and demographics extracted from a data warehouse of a large Southwest institution, this study explored the factors that could distinguish…

Estimating Deterioration in the Concrete Tie-Ballast Interface Based on Vertical Tie Deflection Profile: A Numerical Study

DOT National Transportation Integrated Search

2016-04-12

In ballasted concrete tie track, the tie-ballast interface can : deteriorate resulting in concrete tie bottom abrasion, ballast : pulverization and/or voids in tie-ballast interfaces. Tie-ballast : voids toward tie ends can lead to unfavorable center...

An agent-based model for emotion contagion and competition in online social media

NASA Astrophysics Data System (ADS)

Fan, Rui; Xu, Ke; Zhao, Jichang

2018-04-01

Recent studies suggest that human emotions diffuse in not only real-world communities but also online social media. However, a comprehensive model that considers up-to-date findings and multiple online social media mechanisms is still missing. To bridge this vital gap, an agent-based model, which concurrently considers emotion influence and tie strength preferences, is presented to simulate the emotion contagion and competition. Our model well reproduces patterns observed in the empirical data, like anger's preference on weak ties, anger-dominated users' high vitalities and angry tweets' short retweet intervals, and anger's competitiveness in negative events. The comparison with a previously presented baseline model further demonstrates its effectiveness in modeling online emotion contagion. It is also surprisingly revealed by our model that as the ratio of anger approaches joy with a gap less than 12%, anger will eventually dominate the online social media and arrives the collective outrage in the cyber space. The critical gap disclosed here can be indeed warning signals at early stages for outrage control. Our model would shed lights on the study of multiple issues regarding emotion contagion and competition in terms of computer simulations.

Analysis Influence of Managerial Competence, Technical Competence, and Strategic Competence on Firm Performance in Electrical Engineering Company in Bandung

NASA Astrophysics Data System (ADS)

Wijaya, E. R.; Irianto, D.

2018-03-01

The industry sectors that have an important role in the era of globalization is the electro engineering sector. The era of globalization led to intense competition. One of the negative effects of the intense competition is declining profits. Drop in profits caused many firms reduces their employees without seeking the root cause of declining profits in detail. Whereas, employee is the important resources to maintain competitive advantage. Competitive advantage can be measured by the performance of which is owned by the firm. The firm's performance can be formed of competencies that is unique, rare, irreplaceable, and difficult to imitate within the firm, one of them is the competence of the individual. According to a competency-based approach and the resource- based approach, individual competence that affect the performance of the firm is managerial competence, technical competence, and strategic competence. Questionnaire is built based on the dimensions of the firm's performance, managerial competence, technical competence, and strategic competence, are processed using partial least squares application. The results indicate that managerial competence negatively impact firm’s performance with weak ties. The technical competence and strategic competence positively affect firm’s performance with moderate ties.

Network Effects on Scientific Collaborations

PubMed Central

Uddin, Shahadat; Hossain, Liaquat; Rasmussen, Kim

2013-01-01

Background The analysis of co-authorship network aims at exploring the impact of network structure on the outcome of scientific collaborations and research publications. However, little is known about what network properties are associated with authors who have increased number of joint publications and are being cited highly. Methodology/Principal Findings Measures of social network analysis, for example network centrality and tie strength, have been utilized extensively in current co-authorship literature to explore different behavioural patterns of co-authorship networks. Using three SNA measures (i.e., degree centrality, closeness centrality and betweenness centrality), we explore scientific collaboration networks to understand factors influencing performance (i.e., citation count) and formation (tie strength between authors) of such networks. A citation count is the number of times an article is cited by other articles. We use co-authorship dataset of the research field of ‘steel structure’ for the year 2005 to 2009. To measure the strength of scientific collaboration between two authors, we consider the number of articles co-authored by them. In this study, we examine how citation count of a scientific publication is influenced by different centrality measures of its co-author(s) in a co-authorship network. We further analyze the impact of the network positions of authors on the strength of their scientific collaborations. We use both correlation and regression methods for data analysis leading to statistical validation. We identify that citation count of a research article is positively correlated with the degree centrality and betweenness centrality values of its co-author(s). Also, we reveal that degree centrality and betweenness centrality values of authors in a co-authorship network are positively correlated with the strength of their scientific collaborations. Conclusions/Significance Authors’ network positions in co-authorship networks influence the performance (i.e., citation count) and formation (i.e., tie strength) of scientific collaborations. PMID:23469021

Revisiting Nuclear Thermal Propulsion for Human Mars Exploration

NASA Technical Reports Server (NTRS)

Percy, Thomas K.; Rodriguez, Mitchell

2017-01-01

Nuclear Thermal Propulsion (NTP) has long been considered as a viable in-space transportation alternative for delivering crew and cargo to the Martian system. While technology development work in nuclear propulsion has continued over the year, general interest in NTP propulsion applications has historically been tied directly to the ebb and flow of interest in sending humans to explore Mars. As far back as the 1960’s, plans for NTP-based human Mars exploration have been proposed and periodically revisited having most recently been considered as part of NASA Design Reference Architecture (DRA) 5.0. NASA has been investigating human Mars exploration strategies tied to its current Journey to Mars for the past few years however, NTP has only recently been added into the set of alternatives under consideration for in-space propulsion under the Mars Study Capability (MSC) team, formerly the Evolvable Mars Campaign (EMC) team. The original charter of the EMC was to find viable human Mars exploration approaches that relied heavily on technology investment work already underway, specifically related to the development of large Solar Electric Propulsion (SEP) systems. The EMC team baselined several departures from traditional Mars exploration ground rules to enable these types of architectures. These ground rule changes included lower energy conjunction class trajectories with corresponding longer flight times, aggregation of mission elements in cis-Lunar space rather than Low Earth Orbit (LEO) and, in some cases, the pre-deployment of Earth return propulsion systems to Mars. As the MSC team continues to refine the in-space transportation trades, an NTP-based architecture that takes advantage of some of these ground rule departures is being introduced.

Mapping and localization for extraterrestrial robotic explorations

NASA Astrophysics Data System (ADS)

Xu, Fengliang

In the exploration of an extraterrestrial environment such as Mars, orbital data, such as high-resolution imagery Mars Orbital Camera-Narrow Angle (MOC-NA), laser ranging data Mars Orbital Laser Altimeter (MOLA), and multi-spectral imagery Thermal Emission Imaging System (THEMIS), play more and more important roles. However, these remote sensing techniques can never replace the role of landers and rovers, which can provide a close up and inside view. Similarly, orbital mapping can not compete with ground-level close-range mapping in resolution, precision, and speed. This dissertation addresses two tasks related to robotic extraterrestrial exploration: mapping and rover localization. Image registration is also discussed as an important aspect for both of them. Techniques from computer vision and photogrammetry are applied for automation and precision. Image registration is classified into three sub-categories: intra-stereo, inter-stereo, and cross-site, according to the relationship between stereo images. In the intra-stereo registration, which is the most fundamental sub-category, interest point-based registration and verification by parallax continuity in the principal direction are proposed. Two other techniques, inter-scanline search with constrained dynamic programming for far range matching and Markov Random Field (MRF) based registration for big terrain variation, are explored as possible improvements. Creating using rover ground images mainly involves the generation of Digital Terrain Model (DTM) and ortho-rectified map (orthomap). The first task is to derive the spatial distribution statistics from the first panorama and model the DTM with a dual polynomial model. This model is used for interpolation of the DTM, using Kriging in the close range and Triangular Irregular Network (TIN) in the far range. To generate a uniformly illuminated orthomap from the DTM, a least-squares-based automatic intensity balancing method is proposed. Finally a seamless orthomap is constructed by a split-and-merge technique: the mapped area is split or subdivided into small regions of image overlap, and then each small map piece was processed and all of the pieces are merged together to form a seamless map. Rover localization has three stages, all of which use a least-squares adjustment procedure: (1) an initial localization which is accomplished by adjustment over features common to rover images and orbital images, (2) an adjustment of image pointing angles at a single site through inter and intra-stereo tie points, and (3) an adjustment of the rover traverse through manual cross-site tie points. The first stage is based on adjustment of observation angles of features. The second stage and third stage are based on bundle-adjustment. In the third-stage an incremental adjustment method was proposed. Automation in rover localization includes automatic intra/inter-stereo tie point selection, computer-assisted cross-site tie point selection, and automatic verification of accuracy. (Abstract shortened by UMI.)

Rehabilitation in practice: management of lower motor neuron weakness.

PubMed

Ramdharry, Gita M

2010-05-01

This series of articles for rehabilitation in practice aims to cover a knowledge element of the rehabilitation medicine curriculum. Nevertheless they are intended to be of interest to a multidisciplinary audience. The competency addressed in this article is 'The trainee consistently demonstrates a knowledge of the pathophysiology of various specific impairments including lower motor neuron weakness' and 'management approaches for specific impairments including lower motor neuron weakness'.This article explores weakness as a lower motor symptom. Weakness as a primary impairment of neuromuscular diseases is addressed, with recognition of the phenomenon of disuse atrophy, and how weakness impacts on the functional abilities of people with myopathy and neuropathy. Interventions to reduce weakness or address the functional consequences of weakness are evaluated with consideration of safety and clinical application. This paper will allow readers to: (1) appraise the contribution of research in rehabilitation of lower motor neuron weakness to clinical decision making and (2) engage with the issues that arise when researching rehabilitation interventions for lower motor neuron weakness. Impairments associated with neuromuscular conditions can lead to significant functional difficulties that can impact on a person's daily participation. This article focuses on the primary impairment of weakness and explores the research evidence for rehabilitation interventions that directly influence weakness or address the impact of weakness on function.

Ethics and technology transfer: patients, patents, and public trust.

PubMed

Zucker, Deborah

2011-06-01

Universities and academic medical centers have been increasing their focus on technology transfer and research commercialization. With this shift in focus, academic-industry ties have become prevalent. These relationships can benefit academic researchers and help then to transform their research into tangible societal benefits. However, there also are concerns that these ties and the greater academic focus on commercialization might lead to conflicts of interest, especially financial conflicts of interest. This paper briefly explores some of these conflicts of interest, particularly relating to research and training. This paper also discusses some of the policies that have been, and are being, developed to try to mitigate and manage these conflicts so that academic involvement in technology transfer and commercialization can continue without jeopardizing academic work or the public's trust in them.

Selective removal of organic contaminants from sediments: A methodology for toxicity identification evaluations (TIEs)

USGS Publications Warehouse

Lebo, J.A.; Huckins, J.N.; Petty, J.D.; Ho, K.T.; Stern, E.A.

2000-01-01

Aqueous slurries of a test sediment spiked with dibenz[a,h]anthracene, 2,4,5,2′,4′,5′-hexachlorobiphenyl, p,p′-DDE, or phenanthrene were subjected to decontamination experimentation. The spiked sediments were agitated at elevated temperatures for at least 96 h in the presence of either of the two contaminant-absorbing media: clusters of polyethylene membrane or lipid-containing semipermeable membrane devices (SPMDs). The effects of treatment temperature and surface area of media on the removal of contaminants were explored. This work is part of a larger methodology for whole-sediment toxicity identification evaluation (TIE). A method is being sought that is capable of detoxifying sediments with respect to organic contaminants while leaving toxicity attributable to inorganic contaminants unaffected.

Recognizing surgeon's actions during suture operations from video sequences

NASA Astrophysics Data System (ADS)

Li, Ye; Ohya, Jun; Chiba, Toshio; Xu, Rong; Yamashita, Hiromasa

2014-03-01

Because of the shortage of nurses in the world, the realization of a robotic nurse that can support surgeries autonomously is very important. More specifically, the robotic nurse should be able to autonomously recognize different situations of surgeries so that the robotic nurse can pass necessary surgical tools to the medical doctors in a timely manner. This paper proposes and explores methods that can classify suture and tying actions during suture operations from the video sequence that observes the surgery scene that includes the surgeon's hands. First, the proposed method uses skin pixel detection and foreground extraction to detect the hand area. Then, interest points are randomly chosen from the hand area so that their 3D SIFT descriptors are computed. A word vocabulary is built by applying hierarchical K-means to these descriptors, and the words' frequency histogram, which corresponds to the feature space, is computed. Finally, to classify the actions, either SVM (Support Vector Machine), Nearest Neighbor rule (NN) for the feature space or a method that combines "sliding window" with NN is performed. We collect 53 suture videos and 53 tying videos to build the training set and to test the proposed method experimentally. It turns out that the NN gives higher than 90% accuracies, which are better recognition than SVM. Negative actions, which are different from either suture or tying action, are recognized with quite good accuracies, while "Sliding window" did not show significant improvements for suture and tying and cannot recognize negative actions.

Fluid Centrality: A Social Network Analysis of Social-Technical Relations in Computer-Mediated Communication

ERIC Educational Resources Information Center

Enriquez, Judith Guevarra

2010-01-01

In this article, centrality is explored as a measure of computer-mediated communication (CMC) in networked learning. Centrality measure is quite common in performing social network analysis (SNA) and in analysing social cohesion, strength of ties and influence in CMC, and computer-supported collaborative learning research. It argues that measuring…

Despite available habitat at range edge, yellow-cedar migration is punctuated with a past pulse tied to colder conditions

Treesearch

John Krapek; Paul E. Hennon; David V. D' Amore; Brian Buma

2017-01-01

Aim: To explore the recent (past ~1,000 year) migration history of yellow-cedar (Callitropsis nootkatensis), a climate-threatened tree, which appears to lag behind its potential climatic niche at a leading northern range edge, and infer its continued migration potential under changing climate. Location:...

Dominicanas entre La Gran Manzana y Quisqueya: Family, Schooling, and Language Learning in a Transnational Context

ERIC Educational Resources Information Center

Rodriguez, Tracy

2009-01-01

Drawing from a one-year qualitative research study, this article explores the transnational lives and experiences of three young women and their little sisters in New York with close ties to the Dominican Republic. Using ethnographic research methods--life history interviews, focus groups, participant observation, and document analysis, I examine…

A Place for Everything: Geographic Analysis and Geospatial Tech in Schools

ERIC Educational Resources Information Center

Fitzpatrick, Charlie

2011-01-01

Everyone should be able to read, communicate their ideas, and work effectively with everyday numbers and scientific thinking. But many need a closer tie between book learning and the real world, a reason to dig deeper into facts and principles, the opportunity to relate subjects to what they know. Kids are natural explorers and integrators. The…

The Performance Cycle: The Association between Student Achievement and State Policies Tying Together Teacher Performance, Student Achievement, and Accountability

ERIC Educational Resources Information Center

Alexander, Nicola A.; Jang, Sung Tae; Kankane, Shipi

2017-01-01

This article explores the associations between student performance and the presence of state policies that include student achievement in teacher evaluations. We examined performance among states from 2007 through 2013. Including student performance in state teacher evaluation policies is modestly associated with higher reading achievement but had…

Intentional Families: Fictive Kin Ties between Cross-Gender, Different Sexual Orientation Friends

ERIC Educational Resources Information Center

Muraco, Anna

2006-01-01

This study explores the nature of intentional family relationships between friends of different genders and different sexual orientations. Drawing on in-depth interviews with 46 members of 23 friendship dyads, I first make the case that the friends considered one another family and I specify the criteria they use for making such designations. I…

From Credit to Collective Action: The Role of Microfinance in Promoting Women's Social Capital and Normative Influence

ERIC Educational Resources Information Center

Sanyal, Paromita

2009-01-01

Can economic ties positively influence social relations and actions? If so, how does this influence operate? Microfinance programs, which provide credit through a group-based lending strategy, provide the ideal setting for exploring these questions. This article examines whether structuring socially isolated women into peer-groups for an…

Exploring Capacity for Meaning Making in Relation to Educational Resilience in First-Year, Full-Time College Students

ERIC Educational Resources Information Center

Korgan, Christos; Durdella, Nathan

2016-01-01

Students' success in overcoming difficult academic and social circumstances is tied to educational resilience, yet the current body of literature fails to unpack the complexities of resilience in relation to students' interpretation of themselves and environmental messages. To examine this phenomenon, this study used a narrative inquiry approach…

Perceived Influence of an Instructional Coaching Program on Teacher Self-Efficacy: Voluntary Participation in Comparison to Mandated Participation

ERIC Educational Resources Information Center

Wiedlich, David Matthew

2017-01-01

This research study explored perceived influence of an instructional coaching program on teacher self-efficacy based on voluntary participation in comparison to mandated participation. At the time of this study, the literature on instructional coaching incorporated studies that tie instructional coaching to increases in teacher self-efficacy;…

Food, Obesity Discourses and the Subjugation of Environmental Knowledge

ERIC Educational Resources Information Center

O'Flynn, Gabrielle

2015-01-01

In this article, I critically analyse how meanings of health and food, tied to obesity reduction, "subjugate" environmental priorities and knowledges of food. To do this, I explore the meanings of health and food constructed in the NSW Health Munch & Move program. I examine the use of language to construct notions of food and health…

75 FR 70061 - Bureau of Educational and Cultural Affairs (ECA) Request for Grant Proposals: The Future Leaders...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-16

... American society for an academic year. In turn, these students will expose U.S. citizens to the culture... of Eurasia and the United States by enabling students to: Gain an understanding of American culture... countries and cultures; Interact with Americans and generate enduring ties; Explore and acquire an...

Adoptive Parents, Adaptive Parents: Evaluating the Importance of Biological Ties for Parental Investment

ERIC Educational Resources Information Center

Hamilton, Laura; Cheng, Simon; Powell, Brian

2007-01-01

Contemporary legal and scholarly debates emphasize the importance of biological parents for children's well-being. Scholarship in this vein often relies on stepparent families even though adoptive families provide an ideal opportunity to explore the role of biology in family life. In this study, we compare two-adoptive-parent families with other…

Tongue-Tied No More: Diversity Pedagogy and Sense of Place in the Learning Gardens

ERIC Educational Resources Information Center

Williams, Dilafruz; Anderson, Jennifer

2015-01-01

This case study explores what it is like for culturally and linguistically diverse adolescents who are low-income English Language Learners to experience garden-based education at their school's Learning Gardens in southeast Portland, Oregon, even as they and their families--driven from their homelands as immigrants and refugees--try to establish…

When Money Really Matters: Tying Resources of Specific Programmatic and Instructional Elements to Student Academic Growth

ERIC Educational Resources Information Center

Goetz, Michael Eric

2012-01-01

This study explores the cost-effectiveness ratios associated with individual tutoring, intensive reading/language arts instruction, and a focus on core subject areas. Using the Early Childhood Longitudinal Study (ECLS-K) database, this study analyzes these programs using a three-level hierarchical linear model (HLM) with a nationally…

The patient safety culture: a systematic review by characteristics of Hospital Survey on Patient Safety Culture dimensions.

PubMed

Reis, Cláudia Tartaglia; Paiva, Sofia Guerra; Sousa, Paulo

2018-05-08

To learn the weaknesses and strengths of safety culture as expressed by the dimensions measured by the Hospital Survey on Patient Safety Culture (HSOPSC) at hospitals in the various cultural contexts. The aim of this study was to identify studies that have used the HSOPSC to collect data on safety culture at hospitals; to survey their findings in the safety culture dimensions and possible contributions to improving the quality and safety of hospital care. Medline (via PubMed), Web of Science and Scopus were searched from 2005 to July 2016 in English, Portuguese and Spanish. Studies were identified using specific search terms and inclusion criteria. A total of 33 articles, reporting on 21 countries, was included. Scores were extracted by patient safety culture dimensions assessed by the HSOPSC. The quality of the studies was evaluated by the STROBE Statement. The dimensions that proved strongest were 'Teamwork within units' and 'Organisational learning-continuous improvement'. Particularly weak dimensions were 'Non-punitive response to error', 'Staffing', 'Handoffs and transitions' and 'Teamwork across units'. The studies revealed a predominance of hospital organisational cultures that were underdeveloped or weak as regards patient safety. For them to be effective, safety culture evaluation should be tied to strategies designed to develop safety culture hospital-wide.

Geographical impacts on social networks from perspectives of space and place: an empirical study using mobile phone data

NASA Astrophysics Data System (ADS)

Shi, Li; Wu, Lun; Chi, Guanghua; Liu, Yu

2016-10-01

Space and place are two fundamental concepts in geography. Geographical factors have long been known as drivers of many aspects of people's social networks. But whether and how space and place affect social networks differently are still unclear. The widespread use of location-aware devices provides a novel source for distinguishing the mechanisms of their impacts on social networks. Using mobile phone data, this paper explores the effects of space and place on social networks. From the perspective of space, we confirm the distance decay effect in social networks, based on a comparison between synthetic social ties generated by a null model and actual social ties derived from real-world data. From the perspective of place, we introduce several measures to evaluate interactions between individuals and inspect the trio relationship including distance, spatio-temporal co-occurrence, and social ties. We found that people's interaction is a more important factor than spatial proximity, indicating that the spatial factor has a stronger impact on social networks in place compared to that in space. Furthermore, we verify the hypothesis that interactions play an important role in strengthening friendships.

Resilience in Elders of the Sardinian Blue Zone: An Explorative Study.

PubMed

Fastame, Maria Chiara; Hitchcott, Paul Kenneth; Mulas, Ilaria; Ruiu, Marilena; Penna, Maria Pietronilla

2018-02-26

Background : older adults from the Sardinian Blue Zone self-report low depressive symptoms and high psychological well-being. However, the role of dispositional resilience as a determinant of these characteristics is unknown. Objectives : the current study had three aims. First, to investigate associations among several putative predictors, including dispositional resilience and three established markers of positive and negative mental health. Second, to determine if gender differences in dispositional resilience, independent of age and cognitive impairment, are present in this population. Third, to examine the relative importance of the predictors of self-reported mental health and well-being. Methods : 160 elders were recruited in the Sardinian Blue Zone. The participants completed self-report measures of dispositional resilience, satisfaction with social ties, physical health, depressive symptoms, and psychological well-being. Results : trait resilience was significantly associated with predictors and markers of mental health. Males had significantly greater trait resilience. In regression analyses, dispositional resilience and satisfaction with social ties were significant predictors of all markers of mental health. Other factors were significantly associated only with certain markers. Conclusions : trait resilience and strong social ties appear to be key determinants of the high mental health of Sardinian Blue Zone older adults.

Contextualising migrants' health behaviour - a qualitative study of transnational ties and their implications for participation in mammography screening.

PubMed

Lue Kessing, Linnea; Norredam, Marie; Kvernrod, Ann-Britt; Mygind, Anna; Kristiansen, Maria

2013-05-03

Lower participation rates in mammography screening are common among migrant women compared to native-born women. Explanations of these lower rates have mainly been based on behavioural theories investigating how lack of knowledge, access to services and culture influence the screening behaviour. The aim of the present study was to contextualise screening behaviour by exploring migrants' transnational ties and their influence on participation in mammography screening in Denmark. The study is based on the analysis of qualitative interviews with 29 women residing in greater Copenhagen, Denmark and born in Somalia, Turkey, India, Iran, Pakistan and Arab-speaking countries. We found that while women had knowledge about breast cancer and mammography screening, it was not prioritised. All women were embedded in transnational ties, which they struggled to retain through emotional and financial obligations, and these current struggles in their everyday life seemed to leave little room for concerns about breast cancer and therefore seemed to contribute to their lower participation in screening. The study emphasises the need to take into account the multi-layered and multi-sided factors in migrants' everyday life in order to further understand their health behaviour.

Control of gel swelling and phase separation of weakly charged thermoreversible gels by salt addition

PubMed Central

Solis, Francisco J.; Vernon, Brent

2009-01-01

Doping of thermoreversible polymer gels with charged monomers provides a way to control phase separation and gelation conditions by coupling the properties of the gel with a tunable ionic environment. We analyze the dependence of the gelation and phase separation conditions on the amount of salt present using a mean field model of weakly charged associative polymers. The ions and co-ions present are explicitly considered at the mean field level, and we determine their concentrations in the different equilibrium phases when the system undergoes phase separation. For weak polymer charge, the entropic contributions of the ions to the free energy of the system play a central role in the determination of the location of phase equilibrium. In the simplest case, when the associative interaction responsible for gel formation is independent of the electrostatic interaction, the addition of salt changes the polymer equilibrium concentrations and indirectly changes the measurable swelling of the gel. We construct phase diagrams of these systems showing the location of the coexistence region, the gel-sol boundary and the location of the tie-lines. We determine the swelling of the gel within the co-existence region. Our main result is that the description of the effect of the salt on the properties of the weakly charged gel can be described through an extra contribution to the effective immiscibility parameter χ proportional to the square of the doping degree f2 and to the inverse square of the added salt concentration s−2. PMID:19759854

Ties that bind.

PubMed

Kirkman, A M

2001-01-01

SUMMARY This paper explores how a group of Pakeha women who self-identify as lesbian, gay, or homosexual set about constructing new ways of being Christian, influenced by feminist world-views and an ethos of self-awareness. This construction meshes with new ways of being religious in modern societies, but it also demonstrates how lesbian women have much in common with other women within Christian churches. This paper, therefore, signals the continuing importance of gender as an intervening structure when exploring the relationship between sexuality and religion, specifically, the relationship between being lesbian and being Christian.

Modeling the effect of social networks on adoption of multifunctional agriculture.

PubMed

Manson, Steven M; Jordan, Nicholas R; Nelson, Kristen C; Brummel, Rachel F

2016-01-01

Rotational grazing (RG) has attracted much attention as a cornerstone of multifunctional agriculture (MFA) in animal systems, potentially capable of producing a range of goods and services of value to diverse stakeholders in agricultural landscapes and rural communities, as well as broader societal benefits. Despite these benefits, global adoption of MFA has been uneven, with some places seeing active participation, while others have seen limited growth. Recent conceptual models of MFA emphasize the potential for bottom-up processes and linkages among social and environmental systems to promote multifunctionality. Social networks are critical to these explanations but how and why these networks matter is unclear. We investigated fifty-three farms in three states in the United States (New York, Wisconsin, Pennsylvania) and developed a stylized model of social networks and systemic change in the dairy farming system. We found that social networks are important to RG adoption but their impact is contingent on social and spatial factors. Effects of networks on farmer decision making differ according to whether they comprise weak-tie relationships, which bridge across disparate people and organizations, or strong-tie relationships, which are shared by groups in which members are well known to one another. RG adoption is also dependent on features of the social landscape including the number of dairy households, the probability of neighboring farmers sharing strong ties, and the role of space in how networks are formed. The model replicates features of real-world adoption of RG practices in the Eastern US and illustrates pathways toward greater multifunctionality in the dairy landscape. Such models are likely to be of heuristic value in network-focused strategies for agricultural development.

Modeling the effect of social networks on adoption of multifunctional agriculture

PubMed Central

Manson, Steven M.; Jordan, Nicholas R.; Nelson, Kristen C.; Brummel, Rachel F.

2014-01-01

Rotational grazing (RG) has attracted much attention as a cornerstone of multifunctional agriculture (MFA) in animal systems, potentially capable of producing a range of goods and services of value to diverse stakeholders in agricultural landscapes and rural communities, as well as broader societal benefits. Despite these benefits, global adoption of MFA has been uneven, with some places seeing active participation, while others have seen limited growth. Recent conceptual models of MFA emphasize the potential for bottom-up processes and linkages among social and environmental systems to promote multifunctionality. Social networks are critical to these explanations but how and why these networks matter is unclear. We investigated fifty-three farms in three states in the United States (New York, Wisconsin, Pennsylvania) and developed a stylized model of social networks and systemic change in the dairy farming system. We found that social networks are important to RG adoption but their impact is contingent on social and spatial factors. Effects of networks on farmer decision making differ according to whether they comprise weak-tie relationships, which bridge across disparate people and organizations, or strong-tie relationships, which are shared by groups in which members are well known to one another. RG adoption is also dependent on features of the social landscape including the number of dairy households, the probability of neighboring farmers sharing strong ties, and the role of space in how networks are formed. The model replicates features of real-world adoption of RG practices in the Eastern US and illustrates pathways toward greater multifunctionality in the dairy landscape. Such models are likely to be of heuristic value in network-focused strategies for agricultural development. PMID:26744579

Use of Appreciative Inquiry to Explore the Experiences of Faculty Advisors

ERIC Educational Resources Information Center

Myers, Valerie Ann-Marie

2013-01-01

Academic advising significantly impacts student achievement, persistence, and retention, yet it continues to be an area of weakness for many institutions. The purpose of this sequential mixed-methods case study was to explore the experiences of faculty advisors to identify strengths and weaknesses in their knowledge and skills. Appreciative…

Analyzing Unstructured Communication in a Computer-Mediated Environment for Adults With Type 2 Diabetes: A Research Protocol.

PubMed

Lewinski, Allison A; Anderson, Ruth A; Vorderstrasse, Allison A; Fisher, Edwin B; Pan, Wei; Johnson, Constance M

2017-04-24

Individuals with type 2 diabetes have an increased risk for comorbidities such as heart disease, lower limb amputations, stroke, and renal failure. Multiple factors influence development of complications in a person living with type 2 diabetes; however, an individual's self-management behaviors may delay the onset of, or lessen the severity of, these complications. Social support provides personal, informal advice and knowledge that helps individuals initiate and sustain self-management and adherence. Our aim was to gain an understanding of type 2 diabetes social interaction in a virtual environment, one type of computer-mediated environment (CME), and the social support characteristics that increase and sustain self-management in adults living with chronic illness. This study is a secondary analysis of longitudinal data collected in a CME study, Second Life Impacts Diabetes Education & Self-Management (1R21-LM010727-01). This virtual environment replicated a real-life community where 6 months of naturalistic synchronous voice conversations, emails, and text chats were recorded among participants and providers. This analysis uses a mixed-methods approach to explore and compare qualitative and quantitative findings. This analysis is guided by two theories: Strong/Weak Ties Theory and Social Penetration Theory. Qualitative data will be analyzed using content analysis, and we will complete descriptive statistics on the quantified variables (eg, average number of ties). Institutional review board approval was obtained in June 2016. This study is in progress. Interventions provided through virtual environments are a promising solution to increasing self-management practices. However, little is known of the depth, breadth, and quality of social support that is exchanged and how interaction supports self-management and relates to health outcomes. This study will provide knowledge that will help guide clinical practice and policy to enhance social support for chronic illness via the Internet. ©Allison A Lewinski, Ruth A Anderson, Allison A Vorderstrasse, Edwin B Fisher, Wei Pan, Constance M Johnson. Originally published in JMIR Research Protocols (http://www.researchprotocols.org), 24.04.2017.

Experiences of Family Relationships Among Donor-Conceived Families: A Meta-Ethnography.

PubMed

Wyverkens, Elia; Van Parys, Hanna; Buysse, Ann

2015-09-01

In this qualitative evidence synthesis, we explore how family relationships are experienced by parents who used gamete donation to conceive. We systematically searched four databases (PubMed, Web of Science, PsycINFO, and ProQuest) for literature related to this topic and retrieved 25 studies. Through the analysis of the qualitative studies, a comprehensive synthesis and framework was constructed. Following the meta-ethnography approach of Noblit and Hare, four main themes were identified: (a) balancing the importance of genetic and social ties, (b) normalizing and legitimizing the family, (c) building strong family ties, and (d) minimizing the role of the donor. Underlying these four main themes, a sense of being "different" and "similar" at the same time was apparent. Findings are discussed in terms of their implications for studying and counseling donor-conceived families. © The Author(s) 2014.

[Railroads, disease, and tropical medicine in Brazil under the First Republic].

PubMed

Benchimol, Jaime Larry; da Silva, André Felipe Cândido

2008-01-01

The article explores the impact of malaria on infrastructure works--above all, railroads--under the republican drive towards modernization. Railways helped tie the territory together and foster the symbolic and material expansion of the Brazilian nation. The scientists entrusted with vanquishing such epidemic outbreaks did not just conduct campaigns; they also undertook painstaking observations of aspects of the disease, including its relations to hosts and the environment, thus contributing to the production of new knowledge of malaria and to the institutionalization of a new field in Brazil, then taking root in Europe's colonies: "tropical medicine." The article shows the ties between these innovations (especially the theory of domiciliary infection) and the sanitary campaigns that helped the railways, which in the 1920s were followed by a new phase in Brazil's anti-malaria efforts.

"They Look Scared": Moving from Service Learning to Learning to Serve in Teacher Education--A Social Justice Perspective

ERIC Educational Resources Information Center

Kirkland, David E.

2014-01-01

This article investigates three teacher learners' service learning experiences, in order to explore the extent to which approaches to service learning can lead to legitimate learning outcomes tied to transformative teacher growth and situated in tenets of social justice. Using student interview data, the author posits that service learning fails…

Community, Diversity, and Conflict among Schoolteachers: The Ties That Blind. Advances in Contemporary Educational Thought Series.

ERIC Educational Resources Information Center

Achinstein, Betty

This book explores how teacher communities differ dramatically in how they deal with conflict, collaborate, think about the purposes of schooling in relation to issues of conflict, frame and seek solutions, and utilize mechanisms to manage their differences. It reflects on current social theories of community and democracy to promote values that…

It's the Quality Not the Quantity of Ties That Matters: Social Networks and Self-Efficacy Beliefs

ERIC Educational Resources Information Center

Siciliano, Michael D.

2016-01-01

This study explores the role of knowledge access and peer influence as mechanisms by which networks may shape teacher self-efficacy. The basic premise is twofold: (a) that peer interaction provides opportunities to access teaching relevant knowledge and thus may reduce uncertainty and (b) that self-efficacy beliefs may be shaped by the efficacy…

Teachers and Their International Relocation: The Effect of Self-Efficacy and Flexibility on Adjustment and Outcome Variables

ERIC Educational Resources Information Center

von Kirchenheim, Clement; Richardson, Warnie

2005-01-01

In this study the adjustment process in a designated group of expatriates, (teachers), who have severed ties with their home country and employer is investigated. Based on existing literature, the value of self-efficacy and flexibility on the adjustment process was explored. It was hypothesised that adjustment would result in reduced turnover…

Becoming a Woman Doctor in Iran: The Formation of Classed and Gendered Selves

ERIC Educational Resources Information Center

Fathi, Mastoureh

2018-01-01

This paper analyses the pedagogical pathways of a group of first-generation Iranian migrant doctors in the UK. It explores the complex system of class production and growing up as a classed subject in Iran, a process that ties young women's educational aspirations to female independence on the one hand and to the modern feminine, heterosexual…

The past, present, and future of soils and human health studies

USDA-ARS?s Scientific Manuscript database

The idea that human health is tied to the soil is not a new one. As far back as approximately 1400 B.C. the Bible depicts Moses as understanding that fertile soil was essential to the well-being of his people. While exploring Canaan, Moses charged the men he sent to evaluate the fertility of the soi...

Children's Implicit and Explicit Ethnic Group Attitudes, Ethnic Group Identification, and Self-Esteem

ERIC Educational Resources Information Center

Davis, Stephanie C.; Leman, Patrick J.; Barrett, Martyn

2007-01-01

An increasing amount of research explores how children distinguish different aspects of ethnic group attitudes. However, little work has focused on how these aspects tie in with other social and psychological processes. In the present study, 112 black and white children aged 5-, 7- and 9-years completed tests of implicit and explicit ethnic group…

The Stories of Our National Past: History and Heritage in a Jewish High School

ERIC Educational Resources Information Center

Zakai, Sivan

2015-01-01

This paper explores the relationship between the teaching of history (the academic study of the past) and the teaching of heritage (meaningful stories tying people to a collective past). The research was conducted in a Jewish high school whose explicit mission involves teaching history through a US history course and heritage through an Israeli…

New BVI C Photometry of Low-Mass Pleiades Stars: Exploring the Effects of Rotation on Broadband Colors

DTIC Science & Technology

2014-08-01

could be distance uncertain- ties and/or metallicity effects. The Hyades is much closer than the Pleiades and Praesepe, and consequently one cannot...statistical significance, the sug- gestion of Stauffer et al. (2003) that for K and early M dwarfs (1.0 < B−V < 1.45) in the Pleiades rapid rotation

Integrated diagnostics

NASA Technical Reports Server (NTRS)

Hunthausen, Roger J.

1988-01-01

Recently completed projects in which advanced diagnostic concepts were explored and/or demonstrated are summarized. The projects begin with the design of integrated diagnostics for the Army's new gas turbine engines, and advance to the application of integrated diagnostics to other aircraft subsystems. Finally, a recent project is discussed which ties together subsystem fault monitoring and diagnostics with a more complete picture of flight domain knowledge.

The Weakening of Kin Ties: Exploring the Need for Life-World Led Interventions

PubMed Central

Schout, Gert; de Jong, Gideon

2018-01-01

The protective features that families and wider social relationships can have are required to meet the demands of life in contemporary Western societies. Choice and detraditionalization, however; impede this source of solidarity. Family Group Conferencing (FGC) and other life-world led interventions have the potential to strengthen primary groups. This paper explores the need for such a social intervention, using insights from sociological and philosophical theories and empirical findings from a case study of the research project ‘FGC in mental health’. This need is understandable considering the weakening of kin ties, the poor qualities of state agencies to mobilise self-care and informal care, its capacity to produce a shift of power from public to private spheres and its capacity to mitigate the co-isolation of individuals, families and communities. A life-world led intervention like FGC with a specific and modest ambition contributes to small-scale solidarity. This ambition is not inclined to establish a broad social cohesion within society but to restore; in terms of the German philosopher Peter Sloterdijk; immunity (protection) and solidarity in primary groups, and consequently, resolve issues with those (family, neighbours, colleagues) who share a sphere (a situation, a process, a fate). PMID:29370135

The Weakening of Kin Ties: Exploring the Need for Life-World Led Interventions.

PubMed

Schout, Gert; de Jong, Gideon

2018-01-25

The protective features that families and wider social relationships can have are required to meet the demands of life in contemporary Western societies. Choice and detraditionalization, however; impede this source of solidarity. Family Group Conferencing (FGC) and other life-world led interventions have the potential to strengthen primary groups. This paper explores the need for such a social intervention, using insights from sociological and philosophical theories and empirical findings from a case study of the research project 'FGC in mental health'. This need is understandable considering the weakening of kin ties, the poor qualities of state agencies to mobilise self-care and informal care, its capacity to produce a shift of power from public to private spheres and its capacity to mitigate the co-isolation of individuals, families and communities. A life-world led intervention like FGC with a specific and modest ambition contributes to small-scale solidarity. This ambition is not inclined to establish a broad social cohesion within society but to restore; in terms of the German philosopher Peter Sloterdijk; immunity (protection) and solidarity in primary groups, and consequently, resolve issues with those (family, neighbours, colleagues) who share a sphere (a situation, a process, a fate).

Temporal and Spatial Post-Transcriptional Regulation of Zebrafish Tie1 mRNA by Long Noncoding RNA During Brain Vascular Assembly.

PubMed

Chowdhury, Tamjid A; Koceja, Chris; Eisa-Beygi, Shahram; Kleinstiver, Benjamin P; Kumar, Suresh N; Lin, Chien-Wei; Li, Keguo; Prabhudesai, Shubhangi; Joung, J Keith; Ramchandran, Ramani

2018-05-03

Tie1 (tyrosine kinase containing immunoglobulin and epidermal growth factor homology 1), an endothelial and hematopoietic cell-specific receptor tyrosine kinase, is an important regulator of angiogenesis and critical for maintaining vascular integrity. The post-transcriptional regulation of tie1 mRNA expression is not understood, but it might partly explain Tie1's differential expression pattern in endothelium. Following up on our previous work that identified natural antisense transcripts from the tie1 locus- tie1 antisense ( tie1AS ), which regulates tie1 mRNA levels in zebrafish-we attempted to identify the mechanism of this regulation. Through in vitro and in vivo ribonucleoprotein binding studies, we demonstrated that tie1AS long noncoding RNA interacts with an RNA binding protein-embryonic lethal and abnormal vision Drosophila-like 1 (Elavl1)-that regulates tie1 mRNA levels. When we disrupted the interaction between tie1AS and Elavl1 by using constitutively active antisense morpholino oligonucleotides or photoactivatable morpholino oligonucleotides, tie1 mRNA levels increased between 26 and 31 hours post-fertilization, particularly in the head. This increase correlated with dilation of primordial midbrain channels, smaller eyes, and reduced ventricular space. We also observed these phenotypes when we used CRISPR (clustered regularly interspaced short palindromic repeats)-mediated CRISPRi (CRISPR-mediated interference) to knock down tie1AS . Treatment of the morpholino oligonucleotide-injected embryos with a small molecule that decreased tie1 mRNA levels rescued all 3 abnormal phenotypes. We identified a novel mode of temporal and spatial post-transcriptional regulation of tie1 mRNA. It involves long noncoding RNA, tie1AS, and Elavl1 (an interactor of tie1AS ). © 2018 American Heart Association, Inc.

Disturbed balance between serum levels of receptor tyrosine kinases Tie-1, Tie-2 and angiopoietins in systemic sclerosis.

PubMed

Gerlicz, Zofia; Dziankowska-Bartkowiak, Bozena; Dziankowska-Zaborszczyk, Elzbieta; Sysa-Jedrzejowska, Anna

2014-01-01

The aim of this study was to determine the characteristic factors for vascular development and maintenance levels as well as correlation between Tie-1 receptors, Tie-2 receptors and the corresponding ligands--angiopoietins--in systemic sclerosis (SSc) patients. Serum levels of Tie-1, Tie-2, Ang-1 and Ang-2 were measured in 25 SSc patients and healthy controls. There was a statistically significant difference in serum Tie-1 (p = 0.009) and Ang-2 (p = 0.001) levels in SSc patients compared with healthy controls. Significant correlations between Tie-1 and Tie-2 (ρ = 0.70, p = 0.0001) and between Tie-1 and Ang-2 (ρ = -0.92, p = 0.002) were found in the SSc group. Serum levels of Tie-2 were positively associated with esophagus changes (U = 2.03, p = 0.041) and Ang-1 was negatively correlated with duration of Raynaud's phenomenon (ρ = -0.75, p = 0.00008). The increase in serum concentration of Tie-1 and Ang-2 in patients with SSc may confirm a molecular imbalance between receptor tyrosine kinases Tie and their ligands. © 2014 S. Karger AG, Basel.

Weak Central Coherence and Its Relations to Theory of Mind and Anxiety in Autism

ERIC Educational Resources Information Center

Burnette, Courtney P.; Mundy, Peter C.; Meyer, Jessica A.; Sutton, Steven K.; Vaughan, Amy E.; Charak, David

2005-01-01

Recent theory and research suggests that weak central coherence, a specific perceptual-cognitive style, underlies the central disturbance in autism. This study sought to provide a test of the weak central coherence hypothesis. In addition, this study explored the relations between the weak central coherence hypothesis, theory of mind skills, and…

PWR integral tie plate and locking mechanism

DOE Office of Scientific and Technical Information (OSTI.GOV)

Flora, B.S.; Osborne, J.L.

1980-08-26

A locking mechanism for securing an upper tie plate to the tie rods of a nuclear fuel bundle is described. The mechanism includes an upper tie plate assembly and locking sleeves fixed to the ends of the tie rods. The tie plate is part of the upper tie plate assembly and is secured to the fuel bundle by securing the entire upper tie plate assembly to the locking sleeves fixed to the tie rods. The assembly includes, in addition to the tie plate, locking nuts for engaging the locking sleeves, retaining sleeves to operably connect the locking nuts to themore » assembly, a spring biased reaction plate to restrain the locking nuts in the locked position and a means to facilitate the removal of the entire assembly as a unit from the fuel bundle.« less

Enabling Teachers to Explore Grade Patterns to Identify Individual Needs and Promote Fairer Student Assessment

ERIC Educational Resources Information Center

Friedler, Sorelle A.; Tan, Yee Lin; Peer, Nir J.; Shneiderman, Ben

2008-01-01

Exploring student test, homework, and other assessment scores is a challenge for most teachers, especially when attempting to identify cross-assessment weaknesses and produce final course grades. During the course, teachers need to identify subject weaknesses in order to help students who are struggling with a particular topic. This identification…

Charge segregation in weakly ionized microgels

DOE PAGES

Hyatt, John S.; Douglas, Alison M.; Stanley, Chris; ...

2017-01-19

Here we investigate microgels synthesized from N-isopropylacrylamide (NIPAM) copolymerized with a large mol% of acrylic acid, finding that when the acid groups are partially ionized at high temperatures, competition between ion-induced swelling and hydrophobic deswelling of poly(NIPAM) chains results in microphase separation. In cross-linked microgels, this manifests as a dramatic decrease in the ratio between the radius of gyration and the hydrodynamic radius to ~0.2, indicating that almost all the mass of the microgel is concentrated near the particle center. We also observe a concurrent decrease of the polymer network length scale via small-angle neutron scattering, confirming the presence ofmore » a dense, deswollen core surrounded by a diffuse, charged periphery. We compare these results to those obtained for a system of charged ultralow-cross-linked microgels; the form factor shows a distinct peak at high q when the temperature exceeds a threshold value. Lastly, we successfully fit the form factor to theory developed to describe scattering from weakly charged gels in poor solvents, and we tie this behavior to charge segregation in the case of the cross-linked microgels.« less

Expression and significance of Tie-1 and Tie-2 receptors, and angiopoietins-1, 2 and 4 in colorectal adenocarcinoma: Immunohistochemical analysis and correlation with clinicopathological factors

PubMed Central

Nakayama, Toshiyuki; Hatachi, Go; Wen, Chun-Yang; Yoshizaki, Ayumi; Yamazumi, Kazuyuki; Niino, Daisuke; Sekine, Ichiro

2005-01-01

AIM: There is strong evidence that tyrosine kinases are involved in the regulation of tumor progression, cellular growth and differentiation. Recently, many kinds of tyrosine kinase receptors have been reported, among them Tie-1 and Tie-2 receptors constitute a major class. Angiopoietin (Ang)-1 is known as a ligand of Tie-2 tyrosine kinase receptor. The objective of this study was to establish a comprehensive Tie-1 and Tie-2 and Ang-1, 2 and 4 expression profile in human colorectal adenocarcinomas. METHODS: We examined 96 cases of surgically resected human colorectal adenocarcinoma by immunohistochemistry and investigated the statistical correlation between the expressions of Ties and Angs and clinicopathological factors. RESULTS: Among the 96 cases of adenocarcinoma, 87 (90.6%), 92 (95.8%), 83 (86.5%), 89 (92.7%), and 76 cases (79.2%) showed positive staining in the cytoplasm of carcinoma cells for the Tie-1 and Tie-2 and Ang-1, 2 and 4 proteins, respectively. Histologically, the expressions of Ties and Angs were variable. The expressions of Ties and Angs were correlated with several clinicopathological factors, but did not correlate with the presence of lymph node metastasis. Ties and Angs were highly expressed in human colorectal adenocarcinoma cells. CONCLUSION: These findings suggest that the Tie-Ang receptor-ligand complex is one of the factors involved in the cellular differentiation and progression of human colorectal adenocarcinoma. PMID:15742397

Does the Model Matter? Exploring the Relationship between Different Student Achievement-Based Teacher Assessments. CEDR Working Paper. WP #2012-6

ERIC Educational Resources Information Center

Goldhaber, Dan; Walch, Joe; Gabele, Brian

2012-01-01

Policymakers appear increasingly inclined to utilize measures of student achievement, often state assessment results, to inform high-stakes teacher personnel decisions. This has been spurred on by the federal government's Teacher Incentive Fund (TIF) and Race to the Top (RttT) grant programs, each of which urge states and localities to tie teacher…

Unlocking the Potential Within: A Preliminary Study of Individual and Community Outcomes from a University Enabling Program in Rural Australia

ERIC Educational Resources Information Center

Johns, Susan; Crawford, Nicole; Hawkins, Cherie; Jarvis, Lynn; Harris, Mike; McCormack, David

2016-01-01

Many rural communities have a pool of mature-aged local people seeking a career change or better lifestyle, which inevitably involves reskilling or upskilling. These people have strong local ties and are committed to their community. University enabling programs provide a bridge to higher education. This longitudinal study explores the impact on…

Exploring Teachers' and Students' Gender Role Bias and Students' Confidence in STEM Fields

ERIC Educational Resources Information Center

Hand, Sarah; Rice, Lindsay; Greenlee, Eric

2017-01-01

There is a shortfall of girls and women pursuing STEM disciplines, a deficit that may be partially attributed to subtle forms of bias that are tied to traditional gender role stereotypes. The current study examined these subtle biases in high school teachers and students in two ways: by asking teachers and students to attribute masculine and…

Negotiating Emotional Support: Sober Gay Latinos and their Families

PubMed Central

Moore, Mignon R.; McCuller, William J.; Zaldívar, Richard; Moore, Alison A.

2014-01-01

This study explores how sober gay Latino men obtain support from their families. Familial ties can be a protective health factor, yet many gay Latinos experience rejection from family members because of their sexuality. There are very few studies that examine the extent and quality of emotional support from kin for this population. Understanding family dynamics within the context of recovery and sexuality can increase our understanding of how to leverage family ties to develop alcohol abuse interventions. The study was conducted semi-structured interviews with 30 sober gay Latinos using a grounded theory approach. Analyses of the qualitative data identified the following themes: Family values shaped the participants’ perception of their range of choices and emotional responses; participants reported feeling loved and supported even when sexuality was not discussed with parents; and family support for sobriety is essential. Findings suggest that familial ties shape perceptions of support and importance of disclosing sexual identity. Family support often results from agreements about sexual identity disclosure, and some families can overcome cultural and religious taboos on sexuality. Future studies should investigate families that negotiate acceptance with their gay members, and whether they exhibit heterosexual biases that may influence the psychological stress of gay Latino men who wish to be sober. PMID:25057235

A Comparative Analysis of Domestic Violence Shelter Staff Perceptions Regarding Barriers to Services in Bosnia and Herzegovina and the United States.

PubMed

Grubb, Jonathan A; Muftić, Lisa R

2017-11-01

Service provision for domestic violence (DV) survivors has been a long-standing staple of shelters in the United States. Although shelter services provide numerous benefits for survivors, barriers tied to acquisition remain a pressing concern when combatting DV. Nevertheless, there has been minimal research exploring barriers to service acquisition on a cross-national level. As such, the current research cross-nationally examines perceptions of shelter staff regarding acquisition barriers as well as the effectiveness of local agencies to meet survivor needs and differences in populations served in the United States (specifically Texas) as well as in Bosnia and Herzegovina. Data collection stemmed from self-report surveys originally constructed in English and translated into Bosnian/Serbian/Croatian. Results underscored differences between populations served, perceptions of local agencies assisting survivors of DV, and barriers tied to cultural and financial concerns. Implications, limitations, and future directions are also discussed.

The Social Environment and Childbearing Expectations: Implications for Strength-Based Sexual Health Interventions for Latino Youth.

PubMed

vanDommelen-Gonzalez, Evan; Deardorff, Julianna; Herd, Denise; Minnis, Alexandra M

2016-06-01

In the United States, adolescent childbearing is disproportionately higher among Latino youth, a growing population facing substantial social exclusion. Exploring the relationship between the social environment and sexual health outcomes among Latino youth may offer insights into the development of novel interventions. In this study, Latino youth in partnerships were recruited from neighborhood venues in San Francisco and completed in-depth interviews. Youth reported a desire to complete higher education goals prior to starting a family to improve future opportunities and further personal development. Youth stated that social network members, family and partners, were supportive of their individual childbearing expectations. Social environment barriers tied to poverty, immigration status, and gang violence hindered educational attainment. Some differences were noted by gender and immigrant generation. Building on protective social ties and creating avenues in poor, urban neighborhoods for Latino youth to fully access educational opportunities may counter early childbearing and improve sexual health.

Culture or anonymity? Differences in proposer behaviour in Korea and Germany.

PubMed

Horak, Sven

2015-10-01

This study explores the proposer behaviour in an ultimatum game (UG) frame under anonymous and non-anonymous conditions among a Korean and German subject pool (n = 590) in comparison. Whereas the anonymous condition is represented by the standard UG, the non-anonymous condition integrates an aggregate of the Korean cultural context variables university affiliation, regional origin and seniority. The latter, a classic Confucian context variable, is measured by age differentials. The former two are impactful components of so-called Yongo networks, a unique Korean informal institution identical to Chinese Guanxi ties. Yongo networks, yet underrepresented in research, are said to be a central context variable to explain Korean social ties and decision-making behaviour. We observe significant differences between the offer behaviours of Korean and German subjects when exposing selected cultural variables. We argue that the behavioural differences observed are in fact due to culture not anonymity. © 2015 International Union of Psychological Science.

Managing Boundaries: The Role of Non-Profit Organisations in Russia’s Managed Democracy

PubMed Central

Ljubownikow, Sergej; Crotty, Jo

2017-01-01

This article examines Russian human service non-profit organisations (NPOs) to investigate the nature of civil society in a managed democracy. Specifically the focus is on emerging vertical ties between NPOs and ruling and governing elites. Drawing on qualitative data collected from health and education NPOs in three industrial regions, we find that in establishing such vertical ties the role of organisations and individuals within is changing – they have moved away from ignored outsiders towards accessing the circles of power and being tasked with managing the boundary between the state and civil society. In exploring these arrangements this article highlights that in the post-Soviet space, NPOs and the state are closely intertwined resembling co-optation. As a result the democratisation potential of human service NPOs is constrained. In discussing these insights we also draw parallels to contexts in which the state has outsourced welfare service to human service NPOs. PMID:28989196

Anchoring historical sequences using a new source of astro-chronological tie-points

NASA Astrophysics Data System (ADS)

Dee, Michael W.; Pope, Benjamin J. S.

2016-08-01

The discovery of past spikes in atmospheric radiocarbon activity, caused by major solar energetic particle events, has opened up new possibilities for high-precision chronometry. The two spikes, or Miyake Events, have now been widely identified in tree-rings that grew in the years 775 and 994 CE. Furthermore, all other plant material that grew in these years would also have incorporated the anomalously high concentrations of radiocarbon. Crucially, some plant-based artefacts, such as papyrus documents, timber beams and linen garments, can also be allocated to specific positions within long, currently unfixed, historical sequences. Thus, Miyake Events represent a new source of tie-points that could provide the means for anchoring early chronologies to the absolute timescale. Here, we explore this possibility, outlining the most expeditious approaches, the current challenges and obstacles, and how they might best be overcome.

When he is "tied": power, vulnerability, and embodied masculinity in Egypt.

PubMed

Ghannam, Farha

2017-10-01

This paper looks at the notion of rabt [tying], the inability of the groom to engage in penetrative intercourse on the wedding night, to explore the relationship between masculinity, embodiment, and sexual performance. Drawing on ethnographic fieldwork in Egypt between 1993 and 2015, this paper explores the notion of groom rabt, how it is socially defined and managed. After presenting my conceptual framework for the study of sexuality and embodiment, the paper moves to discuss the meaning of the wedding night; the social clues people draw on when they identify rabt; how these clues relate different events to the (in)abilities of the groom; and how women, particularly mothers, work to protect and heal their male relatives from this affliction. To understand moments when individuals are unable, or "fail," to produce desirable physical and social effects, it is important that we do not exclusively consider the individual sexed body - the body that is clearly defined, bounded, and invested with unique desires and feelings. We must also consider the broader configurations that connect different bodies, endow them with certain meanings, and produce their materiality. My discussion shows that our understanding of sexuality and reproductive health will continue to be limited if we consider only men or women as separate individuals or as autonomous couples. Exploring moments of biological-social vulnerability, such as rabt, and how they relate to broader projects of gendering helps us understand issues linked to reproductive health and sexual rights in a deeper sense.

Neighbourhood social ties: how much do residential, physical and virtual mobility matter?

PubMed

Knies, Gundi

2013-09-01

Following up on the prediction by classical sociological theorists that neighbours will become irrelevant as societies become more mobile, this research examines the strength of people's social ties with neighbours and the associations thereof with residential, physical and virtual mobility using longitudinal data for Germany. Unlike previous studies, the research considers the three forms of mobility simultaneously and contrasts its effects on social ties with neighbours to those with family. The results show that residential and physical mobility are negatively associated with social ties to neighbours and positively with ties to family. Virtual mobility does not weaken social ties with neighbours but ties with family. The positive association between mobility and social ties with family may not be strong enough to ascertain that people maintain as close social ties to others in the future as it does not outweigh the negative association with visiting neighbours. © London School of Economics and Political Science 2013.

Reforming Long-Term Care Funding in Alberta.

PubMed

Crump, R Trafford; Repin, Nadya; Sutherland, Jason M

2015-01-01

Like many provinces across Canada, Alberta is facing growing demand for long-term care. Issues with the mixed funding model used to pay long-term care providers had Alberta Health Services concerned that it was not efficiently meeting the demand for long-term care. Consequently, in 2010, Alberta Health Services introduced the patient/care-based funding (PCBF) model. PCBF is similar to activity-based funding in that it directly ties the complexity and care needs of long-term care residents to the payment received by long-term care providers. This review describes PCBF and discusses some of its strengths and weaknesses. In doing so, this review is intended to inform other provinces faced with similar long-term care challenges and contemplating their own funding reforms.

Stepfamily Formation: Implications for Adolescent Ties to Mothers, Nonresident Fathers, and Stepfathers

PubMed Central

King, Valarie

2009-01-01

This study examines how the entrance of a stepfather influences adolescent ties to mothers and nonresident fathers, and how prior ties to each biological parent influences the development of stepfather-stepchild ties. Data come from 1753 adolescents in the National Longitudinal Study of Adolescent Health who lived with a single mother in Wave 1 that remained single, cohabited, or married by Wave 2, approximately one year later. Stepfamily formation had little consequence for adolescent-nonresident father ties. Adolescent-mother closeness, however, declined when cohabiting, but not married, stepfathers entered the household. Close ties to married stepfathers were more likely to develop when adolescents were closer to their mothers before stepfather entry. Prior ties to nonresident fathers were unrelated to stepfather-stepchild ties. PMID:20161429

[Construction of recombinant lentiviral vector of Tie2-RNAi and its influence on malignant melanoma cells in vitro].

PubMed

Shan, Xiu-ying; Liu, Zhao-liang; Wang, Biao; Guo, Guo-xiang; Wang, Mei-shui; Zhuang, Fu-lian; Cai, Chuan-shu; Zhang, Ming-feng; Zhang, Yan-ding

2011-07-01

To construct lentivector carrying Tie2-Small interfering RNA (SiRNA), so as to study its influence on malignant melanoma cells. Recombinant plasmid pSilencer 1.0-U6-Tie2-siRNA and plasmid pNL-EGFP were digested with XbaI, ligated a target lentiviral transfer plasmid of pNL-EGFP-U6-Tie2-I or pNL-EGFP-U6-Tie2-II, and then the electrophoresis clones was sequenced. Plasmids of pNL-EGFP-U6-Tie2-I and pNL-EGFP-U6-Tie2-II were constructed and combined with pVSVG and pHelper, respectively, to constitute lentiviral vector system of three plasmids. The Lentiviral vector system was transfected into 293T cell to produce pNL-EGFP-U6-Tie2- I and pNL-EGFP-U6-Tie2-II lentivirus. Then the supernatant was collected to determine the titer. Malignant melanoma cells were infected by both lentiviruses and identified by Realtime RT-PCR to assess inhibitory efficiency. The recombinant lentiviral vectors of Tie2-RNAi were constructed successfully which were analyzed with restriction enzyme digestion and identified by sequencing. And the titer of lentiviral vector was 8.8 x 10(3)/ml, which was determined by 293T cell. The results of Realtime RT-PCR demonstrated that the lentiviral vectors of Tie2-RNAi could infect malignant melanoma cells and inhibit the expression of Tie2 genes in malignant melanoma cells (P<0.01). There was no significant difference in the expression level (P>0.05) between the two lentiviral vectors of Tie2-RNAi. Lentivector carrying Tie2-SiRNA can be constructed successfully and inhibit the expression of Tie2 gene in vitro significantly. The study will supply the theory basis for the further research on the inhibition of tumor growth in vivo.

Working Group Reports and Presentations: Mars Science and Exploration

NASA Technical Reports Server (NTRS)

Beaty, David

2006-01-01

In Mars, the spirit of exploring an exciting and rewarding new frontier is alive. Mars not only offers a unique destination for exploration, but it is also a critical destination for the advancement of human society and preservation of humanity. The exploration of Mars will provide significant social and technological benefits to enhance life on Earth as well. International cooperation will not only be essential to the success of a human presence on Mars, but development of such interactions will jumpstart collaboration on global issues. The eventual commercialization of space holds tremendous opportunities for economic growth. Finally, there is an undeniable basic human need to explore and define our place in the universe. The overarching theme that ties together all of these reasons for exploration is to inspire and unite the global community to pursue a common cause that is much larger than disagreements over ethnic differences or national borders. Continuous inspiration of the public, the scientific community, and the community of Earth are required in order to explore Mars.

Course of Discovery: Educators Living along the Route Traveled by Lewis and Clark Infuse Their Teaching with Modern Tools for Exploration.

ERIC Educational Resources Information Center

Boss, Suzie

2003-01-01

A project to help teachers use technology to enhance learning is tied to the Lewis and Clark Expedition bicentennial, to bring a sense of adventure to learning. A 3-day outdoor workshop emphasizing the Nez Perce role in the expedition and a mapping project tracing changes in Lewiston (Idaho) had 8th-graders using global positioning systems,…

When Names and Schools Collide: Critically Analyzing Depictions of Culturally and Linguistically Diverse Children Negotiating Their Names in Picture Books

ERIC Educational Resources Information Center

Keller, Tina; Franzak, Judith K.

2016-01-01

Names and experiences in schools are often tied together in a child's identity formation. This is true for all children, but becomes an increasingly important topic as classrooms in the United States are becoming more diverse. In this study, we seek to explore the idea of names as identity in picture books depicting minority children. In doing so,…

The flow dependency of Tie2 expression in endotoxemia.

PubMed

Kurniati, Neng F; Jongman, Rianne M; vom Hagen, Franziska; Spokes, Katherine C; Moser, Jill; Regan, Erzsébet Ravasz; Krenning, Guido; Moonen, Jan-Renier A J; Harmsen, Martin C; Struys, Michel M R F; Hammes, Hans-Peter; Zijlstra, Jan G; Aird, William C; Heeringa, Peter; Molema, Grietje; van Meurs, Matijs

2013-07-01

Tie2 is predominantly expressed by endothelial cells and is involved in vascular integrity control during sepsis. Changes in Tie2 expression during sepsis development may contribute to microvascular dysfunction. Understanding the kinetics and molecular basis of these changes may assist in the development of therapeutic intervention to counteract microvascular dysfunction. To investigate the molecular mechanisms underlying the changes in Tie2 expression upon lipopolysaccharide (LPS) challenge. Studies were performed in LPS and pro-inflammatory cytokine challenged mice as well as in mice subjected to hemorrhagic shock, primary endothelial cells were used for in vitro experiments in static and flow conditions. Eight hours after LPS challenge, Tie2 mRNA loss was observed in all major organs, while loss of Tie2 protein was predominantly observed in lungs and kidneys, in the capillaries. A similar loss could be induced by secondary cytokines TNF-α and IL-1β. Ang2 protein administration did not affect Tie2 protein expression nor was Tie2 protein rescued in LPS-challenged Ang2-deficient mice, excluding a major role for Ang2 in Tie2 down regulation. In vitro, endothelial loss of Tie2 was observed upon lowering of shear stress, not upon LPS and TNF-α stimulation, suggesting that inflammation related haemodynamic changes play a major role in loss of Tie2 in vivo, as also hemorrhagic shock induced Tie2 mRNA loss. In vitro, this loss was partially counteracted by pre-incubation with a pharmacologically NF-кB inhibitor (BAY11-7082), an effect further substantiated in vivo by pre-treatment of mice with the NF-кB inhibitor prior to the inflammatory challenge. Microvascular bed specific loss of Tie2 mRNA and protein in vivo upon LPS, TNFα, IL-1β challenge, as well as in response to hemorrhagic shock, is likely an indirect effect caused by a change in endothelial shear stress. This loss of Tie2 mRNA, but not Tie2 protein, induced by TNFα exposure was shown to be controlled by NF-кB signaling. Drugs aiming at restoring vascular integrity in sepsis could focus on preventing the Tie2 loss.

The Selective Tie2 Inhibitor Rebastinib Blocks Recruitment and Function of Tie2Hi Macrophages in Breast Cancer and Pancreatic Neuroendocrine Tumors.

PubMed

Harney, Allison S; Karagiannis, George S; Pignatelli, Jeanine; Smith, Bryan D; Kadioglu, Ece; Wise, Scott C; Hood, Molly M; Kaufman, Michael D; Leary, Cynthia B; Lu, Wei-Ping; Al-Ani, Gada; Chen, Xiaoming; Entenberg, David; Oktay, Maja H; Wang, Yarong; Chun, Lawrence; De Palma, Michele; Jones, Joan G; Flynn, Daniel L; Condeelis, John S

2017-11-01

Tumor-infiltrating myeloid cells promote tumor progression by mediating angiogenesis, tumor cell intravasation, and metastasis, which can offset the effects of chemotherapy, radiation, and antiangiogenic therapy. Here, we show that the kinase switch control inhibitor rebastinib inhibits Tie2, a tyrosine kinase receptor expressed on endothelial cells and protumoral Tie2-expressing macrophages in mouse models of metastatic cancer. Rebastinib reduces tumor growth and metastasis in an orthotopic mouse model of metastatic mammary carcinoma through reduction of Tie2 + myeloid cell infiltration, antiangiogenic effects, and blockade of tumor cell intravasation mediated by perivascular Tie2 Hi /Vegf-A Hi macrophages in the tumor microenvironment of metastasis (TMEM). The antitumor effects of rebastinib enhance the efficacy of microtubule inhibiting chemotherapeutic agents, either eribulin or paclitaxel, by reducing tumor volume, metastasis, and improving overall survival. Rebastinib inhibition of angiopoietin/Tie2 signaling impairs multiple pathways in tumor progression mediated by protumoral Tie2 + macrophages, including TMEM-dependent dissemination and angiopoietin/Tie2-dependent angiogenesis. Rebastinib is a promising therapy for achieving Tie2 inhibition in cancer patients. Mol Cancer Ther; 16(11); 2486-501. ©2017 AACR . ©2017 American Association for Cancer Research.

A 10-Year Follow-Up Study of Social Ties and Functional Health among the Old: The AGES Project

PubMed Central

Murata, Chiyoe; Saito, Tami; Tsuji, Taishi; Saito, Masashige

2017-01-01

In Asian nations, family ties are considered important. However, it is not clear what happens among older people with no such ties. To investigate the association, we used longitudinal data from the Aichi Gerontological Evaluation Study (AGES) project. Functionally independent older people at baseline (N = 14,088) in 10 municipalities were followed from 2003 to 2013. Social ties were assessed by asking about their social support exchange with family, relatives, friends, or neighbors. Cox proportional hazard models were employed to investigate the association between social ties and the onset of functional disability adjusting for age, health status, and living arrangement. We found that social ties with co-residing family members, and those with friends or neighbors, independently protected functional health with hazard ratios of 0.81 and 0.85 among men. Among women, ties with friend or neighbors had a stronger effect on health compared to their male counterparts with a hazard ratio of 0.89. The fact that social ties with friends or neighbors are associated with a lower risk of functional decline, independent of family support, serves to underscore the importance of promoting social ties, especially among those lacking family ties. PMID:28671627

Temperature Profile in Fuel and Tie-Tubes for Nuclear Thermal Propulsion Systems

DOE Office of Scientific and Technical Information (OSTI.GOV)

Vishal Patel

A finite element method to calculate temperature profiles in heterogeneous geometries of tie-tube moderated LEU nuclear thermal propulsion systems and HEU designs with tie-tubes is developed and implemented in MATLAB. This new method is compared to previous methods to demonstrate shortcomings in those methods. Typical methods to analyze peak fuel centerline temperature in hexagonal geometries rely on spatial homogenization to derive an analytical expression. These methods are not applicable to cores with tie-tube elements because conduction to tie-tubes cannot be accurately modeled with the homogenized models. The fuel centerline temperature directly impacts safety and performance so it must be predictedmore » carefully. The temperature profile in tie-tubes is also important when high temperatures are expected in the fuel because conduction to the tie-tubes may cause melting in tie-tubes, which may set maximum allowable performance. Estimations of maximum tie-tube temperature can be found from equivalent tube methods, however this method tends to be approximate and overly conservative. A finite element model of heat conduction on a unit cell can model spatial dependence and non-linear conductivity for fuel and tie-tube systems allowing for higher design fidelity of Nuclear Thermal Propulsion.« less

Evaluation of longitudinal joint tie bar system.

DOT National Transportation Integrated Search

2011-09-01

"An adequate longitudinal joint tie bar system is essential in the overall performance of concrete pavement. Excessive : longitudinal joint openings are believed to be caused by either inadequate tie bar size or spacing or improper tie bar : installa...

23 CFR 635.111 - Tied bids.

Code of Federal Regulations, 2010 CFR

2010-04-01

... MAINTENANCE Contract Procedures § 635.111 Tied bids. (a) The STD may tie or permit the tying of Federal-aid...-financed highway projects may be combined in one contract if the conditions of the projects are so similar...

Look Who's Talking. Explaining Water-Related Information Sharing and Demand for Action Among Ugandan Villagers

NASA Astrophysics Data System (ADS)

Holvoet, Nathalie; Dewachter, Sara; Molenaers, Nadia

2016-11-01

Many national water policies propagate community-based participatory approaches to overcome weaknesses in supply-driven rural water provision, operation, and maintenance. Citizen involvement is thought to stimulate bottom-up accountability and broaden the information base, which may enrich design and implementation processes and foster improved water accessibility and sustainability. Practices on the ground, however, are embedded in socio-political realities which mediate possible beneficial effects of participatory approaches. This paper builds on full social network data collected in a Ugandan village to study the social and political reality of two distinct levels of participation, i.e. local information sharing among citizens and a more active appeal to fellow citizens to improve water services. We use Logistic Regression Quadratic Assignment Procedure to explore what type of actor and network traits influence information sharing and whether the same factors are in play in the demand for action to remedy water-related problems. Whereas social aspects (social support relations) and homophily (using the same water source, the same gender) play an important role in information sharing, it is the educational level, in particular, of the villager who is called upon that is important when villagers demand action. Our findings also demonstrate that those most in need of safe water do not mobilize their information sharing ties to demand for action. This indicates that building local water policies and practice exclusively on locally existing demand for action may fail to capture the needs of the most deprived citizens.

Drum tie-down apparatus

DOEpatents

Morse, H.E.

A drum tie-down apparatus for securing drum-like containers in an upright position to a floor or platform of a transportation vehicle having spaced apart cargo tie-down points. The apparatus comprises a pair of cylindrical, hollow tube segments horizontally oriented and engageable with a drum lid adjacent opposite rim edges, flexible strap segments for connecting upper and lower central portions of the tube segments together across the drum lid and a pair of elongated flexible tie-down segments, one extending horizontally through each of the tube segments, the ends thereof being attached to said spaced apart tie-down points such that end portions of the pair of tie-down segments extend downwardly and radially outwardly from the tube segments to the tie-down points.

Drum tie-down apparatus

DOEpatents

Morse, Harvey E.

1984-01-01

A drum tie-down apparatus for securing drum-like containers in an upright position to a floor or platform of a transportation vehicle having spaced apart cargo tie-down points. The apparatus comprises a pair of cylindrical, hollow tube segments horizontally oriented and engageable with a drum lid adjacent opposite rim edges, flexible strap segments for connecting upper and lower central portions of the tube segments together across the drum lid and a pair of elongated flexible tie-down segments, one extending horizontally through each of the tube segments, the ends thereof being attached to said spaced apart tie-down points such that end portions of the pair of tie-down segments extend downwardly and radially outwardly from the tube segments to the tie-down points.

How university students with reading difficulties are supported in achieving their goals.

PubMed

Stack-Cutler, Holly L; Parrila, Rauno K; Jokisaari, Markku; Nurmi, Jari-Erik

2015-01-01

We examine (a) what social ties university students with a history of reading difficulty (RD) report assisting them to achieve their goals, (b) outlets available for developing social ties, (c) resources mobilized within these relationships, and (d) the impact of social ties' status on academic achievement. Participants were 107 university students with RD who were currently completing or had recently completed a university degree. Results showed that university students with RD named friends, parents, and significant others (e.g., boy/girlfriend, spouse) as social ties most often. Personal social ties were developed through social media networking sites and within close relationships, and institutional social ties through academic centers and university general services, among others. Resources mobilized among personal and institutional social ties included emotional and social support, advice and planning, writing and studying help, and goal setting. Institutional social ties also afforded job search assistance, accommodations, skill development, financial support, and mental health services. Finally, the status of employed, but not student, social ties explained academic achievement. © Hammill Institute on Disabilities 2013.

Signaling Network Map of Endothelial TEK Tyrosine Kinase

PubMed Central

Sandhya, Varot K.; Singh, Priyata; Parthasarathy, Deepak; Kumar, Awinav; Gattu, Rudrappa; Mathur, Premendu Prakash; Mac Gabhann, F.; Pandey, Akhilesh

2014-01-01

TEK tyrosine kinase is primarily expressed on endothelial cells and is most commonly referred to as TIE2. TIE2 is a receptor tyrosine kinase modulated by its ligands, angiopoietins, to regulate the development and remodeling of vascular system. It is also one of the critical pathways associated with tumor angiogenesis and familial venous malformations. Apart from the vascular system, TIE2 signaling is also associated with postnatal hematopoiesis. Despite the involvement of TIE2-angiopoietin system in several diseases, the downstream molecular events of TIE2-angiopoietin signaling are not reported in any pathway repository. Therefore, carrying out a detailed review of published literature, we have documented molecular signaling events mediated by TIE2 in response to angiopoietins and developed a network map of TIE2 signaling. The pathway information is freely available to the scientific community through NetPath, a manually curated resource of signaling pathways. We hope that this pathway resource will provide an in-depth view of TIE2-angiopoietin signaling and will lead to identification of potential therapeutic targets for TIE2-angiopoietin associated disorders. PMID:25371820

Pathways for best practice diffusion: the structure of informal relationships in Canada's long-term care sector.

PubMed

Dearing, James W; Beacom, Amanda M; Chamberlain, Stephanie A; Meng, Jingbo; Berta, Whitney B; Keefe, Janice M; Squires, Janet E; Doupe, Malcolm B; Taylor, Deanne; Reid, Robert Colin; Cook, Heather; Cummings, Greta G; Baumbusch, Jennifer L; Knopp-Sihota, Jennifer; Norton, Peter G; Estabrooks, Carole A

2017-02-03

Initiatives to accelerate the adoption and implementation of evidence-based practices benefit from an association with influential individuals and organizations. When opinion leaders advocate or adopt a best practice, others adopt too, resulting in diffusion. We sought to identify existing influence throughout Canada's long-term care sector and the extent to which informal advice-seeking relationships tie the sector together as a network. We conducted a sociometric survey of senior leaders in 958 long-term care facilities operating in 11 of Canada's 13 provinces and territories. We used an integrated knowledge translation approach to involve knowledge users in planning and administering the survey and in analyzing and interpreting the results. Responses from 482 senior leaders generated the names of 794 individuals and 587 organizations as sources of advice for improving resident care in long-term care facilities. A single advice-seeking network appears to span the nation. Proximity exhibits a strong effect on network structure, with provincial inter-organizational networks having more connections and thus a denser structure than interpersonal networks. We found credible individuals and organizations within groups (opinion leaders and opinion-leading organizations) and individuals and organizations that function as weak ties across groups (boundary spanners and bridges) for all studied provinces and territories. A good deal of influence in the Canadian long-term care sector rests with professionals such as provincial health administrators not employed in long-term care facilities. The Canadian long-term care sector is tied together through informal advice-seeking relationships that have given rise to an emergent network structure. Knowledge of this structure and engagement with its opinion leaders and boundary spanners may provide a route for stimulating the adoption and effective implementation of best practices, improving resident care and strengthening the long-term care advice network. We conclude that informal relational pathways hold promise for helping to transform the Canadian long-term care sector.

Prevention of derailments due to concrete tie rail seat deterioration

DOT National Transportation Integrated Search

2007-03-13

Concrete tie rail seat abrasion/deterioration (RSA) has : been an issue since the inception of concrete ties. As a : result of recent derailments involving abraded concrete : ties on curved track, the Federal Railroad Administration : set up a task f...

Computational and Experimental Assessment of Jets in Cross Flow (Evaluation Numerique et Experimentale des Jets dans des Courants Transversaux)

DTIC Science & Technology

1993-11-01

sont caracterises par la striosconic continue tic la la partie tie la couche tie melange situde sous le jet figure 3 ainsi que par la tomoscopie tie... caracterisent les ondzs). Ces ondes un disque; de Mach. Sur la figuire 4, on observe la semblent proveriir tie la r6gion tie l’jccteur, juste trace du

Rival ecologies of global commerce: Adam Smith and the natural historians.

PubMed

Jonsson, Fredrik Albritton

2010-01-01

This essay explores how the defense of global commerce pioneered in the Enlightenment was tied to the improvement of the natural order. Two rival ecologies, one made by natural historians and the other developed by Adam Smith and his liberal successors, vied for intellectual precedence as well as for practical application in the metropole and the colonies. Together they constitute the beginnings of an ongoing quarrel over the environmental foundation of capitalism.

A Technology Integration Education (TIE) Model for Millennial Preservice Teachers: Exploring the Canonical Correlation Relationships among Attitudes, Subjective Norms, Perceived Behavioral Controls, Motivation, and Technological, Pedagogical, and Content Knowledge (TPACK) Competencies

ERIC Educational Resources Information Center

Holland, Denise D.; Piper, Randy T.

2016-01-01

Intellectual goods can follow the same pattern as physical goods with the product life cycle of birth, growth, maturity, and decline. For the intellectual good of technological, pedagogical, and content knowledge (TPACK), its birth began with Shulman (1986, 1987). Canonical correlation analysis (CCA) was used to test the relationships among five…

Minimum accommodation for aerobrake assembly, phase 2

NASA Technical Reports Server (NTRS)

Katzberg, Stephen J.; Haynes, Davy A.; Tutterow, Robin D.; Watson, Judith J.; Russell, James W.

1994-01-01

A multi-element study was done to assess the practicality of a Space Station Freedom-based aerobrake system for the Space Exploration Initiative. The study was organized into six parts related to structure, aerodynamics, robotics and assembly, thermal protection system, inspection, and verification, all tied together by an integration study. The integration activity managed the broad issues related to meeting mission requirements. This report is a summary of the issues addressed by the integration team.

An Exploration of Cohesion in the Land of Combat Service Support

DTIC Science & Technology

1991-12-18

the group AAR the soldier finds that the companions he could not see were doing the same things that he was. Leaders discover actions of subordinates...seventy-eight years, and many wars ago. 39 ENDOUES. £ William Shakespeare , Tie Complete Works of William Shakespeare . (London: Octopus Books, 1986), 478...Beverly Hill, CA: Sage Publications, 1980. Shakespeare , William. The ComDlete Works of William Shakespeare . London: Octopus Books, 1985. Simpkin

Common Cents? The Role of Pennies in the U.S. Economy

DTIC Science & Technology

2006-12-01

economy. This debate stems from political and economical sources with ties to historical references. This paper explores the various reasons for...roughly $.50. Today, that same pound of zinc costs nearly $1.50.14 Additionally, China is currently experiencing an economic whirlwind. The... economic growth in China has turned it from one of the world’s largest zinc exporters to one of the largest zinc importers.15 As a result, many items

Aerothermodynamic Testing of Protuberances and Penetrations on the NASA Crew Exploration Vehicle Heat Shield in the NASA Langley 20-Inch Mach 6 Air Tunnel

NASA Technical Reports Server (NTRS)

Liechty, Derek S.

2008-01-01

An experimental wind tunnel program is being conducted in support of an Agency wide effort to develop a replacement for the Space Shuttle and to support the NASA s long-term objective of returning to the moon and then on to Mars. This paper documents experimental measurements made on several scaled ceramic heat transfer models of the proposed Crew Exploration Vehicle. Global heat transfer images and heat transfer distributions obtained using phosphor thermography were used to infer interference heating on the Crew Exploration Vehicle Cycle 1 heat shield from local protuberances and penetrations for both laminar and turbulent heating conditions. Test parametrics included free stream Reynolds numbers of 1.0x10(exp 6)/ft to 7.25x10(exp 6)/ft in Mach 6 air at a fixed angle-of-attack. Single arrays of discrete boundary layer trips were used to trip the boundary layer approaching the protuberances/penetrations to a turbulent state. Also, the effects of three compression pad diameters, two radial locations of compression pad/tension tie location, compression pad geometry, and rotational position of compression pad/tension tie were examined. The experimental data highlighted in this paper are to be used to validate CFD tools that will be used to generate the flight aerothermodynamic database. Heat transfer measurements will also assist in the determination of the most appropriate engineering methods that will be used to assess local flight environments associated with protuberances/penetrations of the CEV thermal protection system.

The design and application of a Transportable Inference Engine (TIE1)

NASA Technical Reports Server (NTRS)

Mclean, David R.

1986-01-01

A Transportable Inference Engine (TIE1) system has been developed by the author as part of the Interactive Experimenter Planning System (IEPS) task which is involved with developing expert systems in support of the Spacecraft Control Programs Branch at Goddard Space Flight Center in Greenbelt, Maryland. Unlike traditional inference engines, TIE1 is written in the C programming language. In the TIE1 system, knowledge is represented by a hierarchical network of objects which have rule frames. The TIE1 search algorithm uses a set of strategies, including backward chaining, to obtain the values of goals. The application of TIE1 to a spacecraft scheduling problem is described. This application involves the development of a strategies interpreter which uses TIE1 to do constraint checking.

Fatigue is associated with muscle weakness in Ehlers-Danlos syndrome: an explorative study.

PubMed

Voermans, N C; Knoop, H; Bleijenberg, G; van Engelen, B G

2011-06-01

Ehlers-Danlos syndrome (EDS) is a clinically and genetically heterogeneous group of inherited connective tissue disorders characterised by joint hypermobility, skin hyperextensibility and tissue fragility. It has recently been shown that muscle weakness occurs frequently in EDS, and that fatigue is a common and clinically important symptom. The aim of this study was to investigate the relationship between fatigue severity and subjective and objective measures of muscle weakness. Furthermore, the predictive value of muscle weakness for fatigue severity was determined, together with that of pain and physical activity. An explorative, cross-sectional, observational study. Thirty EDS patients, recruited from the Dutch patient association, were investigated at the neuromuscular outpatient department of a tertiary referral centre in The Netherlands. Muscle strength measured with manual muscle strength testing and hand-held dynamometry. Self-reported muscle weakness, pain, physical activity levels and fatigue were assessed with standardised questionnaires. Fatigue severity in EDS was significantly correlated with measured and self-reported muscle weakness (r=-0.408 for manual muscle strength, r=0.461 for hand-held dynamometry and r=0.603 for self-reported muscle weakness). Both muscle weakness and pain severity were significant predictors of fatigue severity in a multiple regression analysis. The results suggest a positive and direct relationship between fatigue severity and muscle weakness in EDS. Future research should focus on the relationship between fatigue, muscle weakness and objectively measured physical activity, preferably in a larger cohort of EDS patients. Copyright © 2010 Chartered Society of Physiotherapy. Published by Elsevier Ltd. All rights reserved.

Selective Inhibition of the Human tie-1 Promoter with Triplex-Forming Oligonucleotides Targeted to Ets Binding Sites

PubMed Central

Hewett, Peter W; Daft, Emma L; Laughton, Charles A; Ahmad, Shakil; Ahmed, Asif; Murray, J Clifford

2006-01-01

The Tie receptors (Tie-1 and Tie-2/Tek) are essential for angiogenesis and vascular remodeling/integrity. Tie receptors are up-regulated in tumor-associated endothelium, and their inhibition disrupts angiogenesis and can prevent tumor growth as a consequence. To investigate the potential of anti-gene approaches to inhibit tie gene expression for anti-angiogenic therapy, we have examined triple-helical (triplex) DNA formation at 2 tandem Ets transcription factor binding motifs (designated E-1 and E-2) in the human tie-1 promoter. Various tie-1 promoter deletion/mutation luciferase reporter constructs were generated and transfected into endothelial cells to examine the relative activities of E-1 and E-2. The binding of antiparallel and parallel (control) purine motif oligonucleotides (21–22 bp) targeted to E-1 and E-2 was assessed by plasmid DNA fragment binding and electrophoretic mobility shift assays. Triplex-forming oligonucleotides were incubated with tie-1 reporter constructs and transfected into endothelial cells to determine their activity. The Ets binding motifs in the E-1 sequence were essential for human tie-1 promoter activity in endothelial cells, whereas the deletion of E-2 had no effect. Antiparallel purine motif oligonucleotides targeted at E-1 or E-2 selectively formed strong triplex DNA (Kd ~10−7 M) at 37 °C. Transfection of tie-1 reporter constructs with triplex DNA at E-1, but not E-2, specifically inhibited tie-1 promoter activity by up to 75% compared with control oligonucleotides in endothelial cells. As similar multiple Ets binding sites are important for the regulation of several endothelial-restricted genes, this approach may have broad therapeutic potential for cancer and other pathologies involving endothelial proliferation/dysfunction. PMID:16838069

Selective inhibition of the human tie-1 promoter with triplex-forming oligonucleotides targeted to Ets binding sites.

PubMed

Hewett, Peter W; Daft, Emma L; Laughton, Charles A; Ahmad, Shakil; Ahmed, Asif; Murray, J Clifford

2006-01-01

The Tie receptors (Tie-1 and Tie-2/Tek) are essential for angiogenesis and vascular remodeling/integrity. Tie receptors are up-regulated in tumor-associated endothelium, and their inhibition disrupts angiogenesis and can prevent tumor growth as a consequence. To investigate the potential of anti-gene approaches to inhibit tie gene expression for anti-angiogenic therapy, we have examined triple-helical (triplex) DNA formation at 2 tandem Ets transcription factor binding motifs (designated E-1 and E-2) in the human tie-1 promoter. Various tie-1 promoter deletion/mutation luciferase reporter constructs were generated and transfected into endothelial cells to examine the relative activities of E-1 and E-2. The binding of antiparallel and parallel (control) purine motif oligonucleotides (21-22 bp) targeted to E-1 and E-2 was assessed by plasmid DNA fragment binding and electrophoretic mobility shift assays. Triplex-forming oligonucleotides were incubated with tie-1 reporter constructs and transfected into endothelial cells to determine their activity. The Ets binding motifs in the E-1 sequence were essential for human tie-1 promoter activity in endothelial cells, whereas the deletion of E-2 had no effect. Antiparallel purine motif oligonucleotides targeted at E-1 or E-2 selectively formed strong triplex DNA (K(d) approximately 10(-7) M) at 37 degrees C. Transfection of tie-1 reporter constructs with triplex DNA at E-1, but not E-2, specifically inhibited tie-1 promoter activity by up to 75% compared with control oligonucleotides in endothelial cells. As similar multiple Ets binding sites are important for the regulation of several endothelial-restricted genes, this approach may have broad therapeutic potential for cancer and other pathologies involving endothelial proliferation/dysfunction.

ORGAN EXTRACTS AND THE DEVELOPMENT OF PSYCHIATRY: HORMONAL TREATMENTS AT THE MAUDSLEY HOSPITAL 1923–1938

PubMed Central

Evans, Bonnie; Jones, Edgar

2012-01-01

The use of organ extracts to treat psychiatric disorder in the interwar period is an episode in the history of psychiatry which has largely been forgotten. An analysis of case-notes from The Maudsley Hospital from the period 1923–1938 shows that the prescription of extracts taken from animal testes, ovaries, thyroids, and other organs was widespread within this London Hospital. This article explores the way in which Maudsley doctors justified these treatments by tying together psychological theories of the unconscious with experimental data drawn from laboratory studies of human organs. It explores the logic behind these treatments and examines beliefs about their efficacy. The connection between this historical episode and current research in endocrinology and psychology is explored. © 2012 Wiley Periodicals, Inc. PMID:22644956

Multicentre randomised double bind crossover trial on contamination of conventional ties and bow ties in routine obstetric and gynaecological practice.

PubMed Central

Biljan, M M; Hart, C A; Sunderland, D; Manasse, P R; Kingsland, C R

1993-01-01

OBJECTIVE--To assess level of contamination of neckwear worn by gynaecologists and obstetricians during routine working week. DESIGN--Multicentre randomised double blind crossover trial. Participants wore the same conventional ties for three days in one week and bow ties for the same period in second week. SETTING--Two teaching and three district general hospitals in the midlands, Wales, and north England. SUBJECTS--15 registrars and senior registrars. INTERVENTIONS--A swab soaked in sterile saline was taken from specific area on ties at end of first and third working days and sent in transport medium for culture on chocolatised blood and MacConkey agar for 48 hours. MAIN OUTCOME MEASURES--Level of bacteriological growth assessed semiquantitatively (0 for no contamination; for heavy contamination) after swabs had been cultured. At end of study the participants completed a questionnaire to assess their attitude toward wearing different types of necktie. RESULTS--12 doctors (80%) completed the study. Although bow ties were significantly less contaminated at end of first working day (z = -2.354, p = 0.019), this difference was not maintained; there was no difference in level of contamination on third day. Level of contamination did not increase between first and third day of wearing the same garment. One of the 10 doctors who returned the questionnaire found the bow tie very uncomfortable. All participants would consider wearing a bow tie if it proved to be less contaminated than a conventional tie. CONCLUSIONS--Although a significant difference in contamination was established between conventional and bow ties on first day of study, this difference was not confirmed on third day and there is unlikely to be any real association between tie type and bacterial contamination. Because of its negative image and difficulty to tie, the bow tie will probably remain a minority fashion. Images p1583-a PMID:8292945

Determining the transfer length in prestressed concrete railroad ties produced in the United States.

DOT National Transportation Integrated Search

2012-05-01

This paper presents results from transfer length measurements on prestressed concrete railroad ties. Results are shown from : the four main producers of concrete ties in the United States. Six prestressed concrete tie plants were visited by the : res...

Angiopoietin receptor Tie2 is required for vein specification and maintenance via regulating COUP-TFII.

PubMed

Chu, Man; Li, Taotao; Shen, Bin; Cao, Xudong; Zhong, Haoyu; Zhang, Luqing; Zhou, Fei; Ma, Wenjuan; Jiang, Haijuan; Xie, Pancheng; Liu, Zhengzheng; Dong, Ningzheng; Xu, Ying; Zhao, Yun; Xu, Guoqiang; Lu, Peirong; Luo, Jincai; Wu, Qingyu; Alitalo, Kari; Koh, Gou Young; Adams, Ralf H; He, Yulong

2016-12-22

Mechanisms underlying the vein development remain largely unknown. Tie2 signaling mediates endothelial cell (EC) survival and vascular maturation and its activating mutations are linked to venous malformations. Here we show that vein formation are disrupted in mouse skin and mesentery when Tie2 signals are diminished by targeted deletion of Tek either ubiquitously or specifically in embryonic ECs. Postnatal Tie2 attenuation resulted in the degeneration of newly formed veins followed by the formation of haemangioma-like vascular tufts in retina and venous tortuosity. Mechanistically, Tie2 insufficiency compromised venous EC identity, as indicated by a significant decrease of COUP-TFII protein level, a key regulator in venogenesis. Consistently, angiopoietin-1 stimulation increased COUP-TFII in cultured ECs, while Tie2 knockdown or blockade of Tie2 downstream PI3K/Akt pathway reduced COUP-TFII which could be reverted by the proteasome inhibition. Together, our results imply that Tie2 is essential for venous specification and maintenance via Akt mediated stabilization of COUP-TFII.

Commentary on: Are we overpathologizing everyday life? A tenable blueprint for behavioral addiction research

PubMed Central

Van Der Linden, Martial

2015-01-01

This commentary proposes a complementary perspective to that developed by Billieux, Schimmenti, Khazaal, Maurage and Heeren (2015). The addiction-as-disease approach tends to sideline explanatory factors of a psychosocial, cultural, political, or historical nature. I therefore suggest taking into account not only the personal characteristics (loss of self-control, impulsivity) related to the disease model, but also the social determinants of addictive behaviors (weak social ties, social exclusion, hyperindividualism, poverty, unemployment, etc.). Moreover, the disease model of addiction removes addictive behaviors from the cultural and historical contexts that shape them. I argue that the cultural and historical reasons for which certain factors (such as loss of self-control) became so important in the explanation of addictive behaviors should be more thoroughly considered. PMID:26551902

HIV/AIDS, social capital, and online social networks.

PubMed

Drushel, Bruce E

2013-01-01

The prospects for online social networks as sites of information-gathering and affiliation for persons with AIDS and others concerned about HIV/AIDS not only represent the latest development in a trend toward circumventing traditional media and official information sources, but also may offer hope for a revitalization of HIV/AIDS discourse in the public sphere. This article provides an overview of three decades of information-seeking on the pandemic and its social and personal implications, as well as case studies of three examples of social networking surrounding HIV/AIDS. It finds preliminary evidence of the formation of strong and weak ties as described in Social Network Theory and suggests that the online accumulation of social capital by opinion leaders could facilitate dissemination of messages on HIV/AIDS awareness and testing.

An experimental study of search in global social networks.

PubMed

Dodds, Peter Sheridan; Muhamad, Roby; Watts, Duncan J

2003-08-08

We report on a global social-search experiment in which more than 60,000 e-mail users attempted to reach one of 18 target persons in 13 countries by forwarding messages to acquaintances. We find that successful social search is conducted primarily through intermediate to weak strength ties, does not require highly connected "hubs" to succeed, and, in contrast to unsuccessful social search, disproportionately relies on professional relationships. By accounting for the attrition of message chains, we estimate that social searches can reach their targets in a median of five to seven steps, depending on the separation of source and target, although small variations in chain lengths and participation rates generate large differences in target reachability. We conclude that although global social networks are, in principle, searchable, actual success depends sensitively on individual incentives.

The Social Environment and Childbearing Expectations: Implications for Strengths-based Sexual Health Interventions for Latino Youth

PubMed Central

vanDommelen-Gonzalez, Evan; Deardorff, Julianna; Herd, Denise; Minnis, Alexandra M.

2015-01-01

In the United States, adolescent childbearing is disproportionately higher among Latino youth, a growing population facing substantial social exclusion. Exploring the relationship between the social environment and sexual health outcomes among Latino youth may offer insights into the development of novel interventions. In this study, Latino youth in partnerships were recruited from neighborhood venues in San Francisco and completed in-depth interviews. Youth reported a desire to complete higher education goals prior to starting a family to improve future opportunities and further personal development. Youth stated that social network members, family and partners, were supportive of their individual childbearing expectations. Social environment barriers tied to poverty, immigration status, and gang violence hindered educational attainment. Some differences were noted by gender and immigrant generation. Building on protective social ties and creating avenues in poor, urban neighborhoods for Latino youth to fully access educational opportunities may counter early childbearing and improve sexual health. PMID:27271070

A right to health: medicine as Western cultural imperialism?

PubMed

Matheson, Donna

2009-01-01

Western medicine is intrinsically tied with modern Western culture, and as such is foreign to many African cultures. Relying on personal observations from working in Angola as a physiotherapist as well as secondary research, the author explores the divide between Angolan culture and medical practices which are deeply rooted in scientific research. Most strikingly, the author finds that concepts of evidence-based medicine as well as individual human or patients' rights contain aspects foreign to Angolan culture. Illustrative examples are given of differences in attitudes towards finances and religion in relation to medicine. Finally, the author proposes that factors such as poverty and illiteracy can play an important role in differences in practices and customs commonly seen as being strictly tied to culture. Although medicine does carry with it components of Western culture, there may be positive components of medicine that non-Westerners would like to adopt. This article suggests that Westerners and Angolans can combine beneficial aspects of Angolan culture with medicine to improve health care for the people of Angola.

Two-phase pressure drop reduction BWR assembly design

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dix, G.E.; Crowther, R.L.; Colby, M.J.

1991-05-21

This patent describes an improved fuel assembly for a boiling water reactor. It comprises: a fuel channel; a lower tie plate; an upper tie plate; the lower tie plate and the upper tie plate defining a two-dimensional matrix; at least one water rod the fuel rods being partial length rods.

nGASP - the nematode genome annotation assessment project

DOE Office of Scientific and Technical Information (OSTI.GOV)

Coghlan, A; Fiedler, T J; McKay, S J

2008-12-19

While the C. elegans genome is extensively annotated, relatively little information is available for other Caenorhabditis species. The nematode genome annotation assessment project (nGASP) was launched to objectively assess the accuracy of protein-coding gene prediction software in C. elegans, and to apply this knowledge to the annotation of the genomes of four additional Caenorhabditis species and other nematodes. Seventeen groups worldwide participated in nGASP, and submitted 47 prediction sets for 10 Mb of the C. elegans genome. Predictions were compared to reference gene sets consisting of confirmed or manually curated gene models from WormBase. The most accurate gene-finders were 'combiner'more » algorithms, which made use of transcript- and protein-alignments and multi-genome alignments, as well as gene predictions from other gene-finders. Gene-finders that used alignments of ESTs, mRNAs and proteins came in second place. There was a tie for third place between gene-finders that used multi-genome alignments and ab initio gene-finders. The median gene level sensitivity of combiners was 78% and their specificity was 42%, which is nearly the same accuracy as reported for combiners in the human genome. C. elegans genes with exons of unusual hexamer content, as well as those with many exons, short exons, long introns, a weak translation start signal, weak splice sites, or poorly conserved orthologs were the most challenging for gene-finders. While the C. elegans genome is extensively annotated, relatively little information is available for other Caenorhabditis species. The nematode genome annotation assessment project (nGASP) was launched to objectively assess the accuracy of protein-coding gene prediction software in C. elegans, and to apply this knowledge to the annotation of the genomes of four additional Caenorhabditis species and other nematodes. Seventeen groups worldwide participated in nGASP, and submitted 47 prediction sets for 10 Mb of the C. elegans genome. Predictions were compared to reference gene sets consisting of confirmed or manually curated gene models from WormBase. The most accurate gene-finders were 'combiner' algorithms, which made use of transcript- and protein-alignments and multi-genome alignments, as well as gene predictions from other gene-finders. Gene-finders that used alignments of ESTs, mRNAs and proteins came in second place. There was a tie for third place between gene-finders that used multi-genome alignments and ab initio gene-finders. The median gene level sensitivity of combiners was 78% and their specificity was 42%, which is nearly the same accuracy as reported for combiners in the human genome. C. elegans genes with exons of unusual hexamer content, as well as those with many exons, short exons, long introns, a weak translation start signal, weak splice sites, or poorly conserved orthologs were the most challenging for gene-finders.« less

China’s Military Support Facility in Djibouti: The Economic and Security Dimensions of China’s First Overseas Base

DTIC Science & Technology

2017-07-01

Cleared for Public Release China’s Military Support Facility in Djibouti: The Economic and Security Dimensions of China’s...paper provides a preliminary look at the origins of China’s military support facility in Djibouti. It explores the evolution of the economic and security...military facilities abroad. It also assesses the implications of the growing economic and military ties between the two countries for the United

21 CFR 876.5820 - Hemodialysis system and accessories.

Code of Federal Regulations, 2010 CFR

2010-04-01

... chair without a scale, the dialyzer holder set, dialysis tie gun and ties, and hemodialysis start/stop..., dialyzer holder set, and dialysis tie gun and ties. The devices subject to this paragraph (b)(2) are exempt from the premarket notification procedures in subpart E of part 807 of this chapter subject to the...

77 FR 21620 - Notice of the Buy America Waiver Request for Vossloh 101-LV Concrete Ties

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-10

... the Buy America Waiver Request for Vossloh 101-LV Concrete Ties AGENCY: Federal Railroad... concrete ties, which contain certain components not manufactured in the United States. In furtherance of... concrete ties. FRA has received this request from the four States for the following projects: (a) The...

78 FR 75545 - Prestressed Concrete Steel Rail Tie Wire From the People's Republic of China: Preliminary...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-12

... Rail Tie Wire From the People's Republic of China: Preliminary Determination of Sales at Less Than Fair... (``Department'') preliminarily determines that prestressed concrete steel rail tie wire (``PC tie wire'') from... steel wire; stress relieved or low relaxation; indented or otherwise deformed; meeting at a minimum the...

Angiopoietin receptor Tie2 is required for vein specification and maintenance via regulating COUP-TFII

PubMed Central

Chu, Man; Li, Taotao; Shen, Bin; Cao, Xudong; Zhong, Haoyu; Zhang, Luqing; Zhou, Fei; Ma, Wenjuan; Jiang, Haijuan; Xie, Pancheng; Liu, Zhengzheng; Dong, Ningzheng; Xu, Ying; Zhao, Yun; Xu, Guoqiang; Lu, Peirong; Luo, Jincai; Wu, Qingyu; Alitalo, Kari; Koh, Gou Young; Adams, Ralf H; He, Yulong

2016-01-01

Mechanisms underlying the vein development remain largely unknown. Tie2 signaling mediates endothelial cell (EC) survival and vascular maturation and its activating mutations are linked to venous malformations. Here we show that vein formation are disrupted in mouse skin and mesentery when Tie2 signals are diminished by targeted deletion of Tek either ubiquitously or specifically in embryonic ECs. Postnatal Tie2 attenuation resulted in the degeneration of newly formed veins followed by the formation of haemangioma-like vascular tufts in retina and venous tortuosity. Mechanistically, Tie2 insufficiency compromised venous EC identity, as indicated by a significant decrease of COUP-TFII protein level, a key regulator in venogenesis. Consistently, angiopoietin-1 stimulation increased COUP-TFII in cultured ECs, while Tie2 knockdown or blockade of Tie2 downstream PI3K/Akt pathway reduced COUP-TFII which could be reverted by the proteasome inhibition. Together, our results imply that Tie2 is essential for venous specification and maintenance via Akt mediated stabilization of COUP-TFII. DOI: http://dx.doi.org/10.7554/eLife.21032.001 PMID:28005008

Ambivalent versus Problematic Social Ties: Implications for Psychological Health, Functional Health, and Interpersonal Coping

PubMed Central

Rook, Karen S.; Luong, Gloria; Sorkin, Dara H.; Newsom, Jason T.; Krause, Neal

2013-01-01

Older adults often seek to manage their social networks to foster positive interactions, but they nonetheless sometimes experience negative interactions that detract from their health and well-being. Negative interactions may occur with ambivalent social partners (i.e., partners involved in both positive and negative exchanges) or exclusively problematic social partners (i.e., partners involved negative exchanges only), but conflicting views exist in the literature regarding which type of social partner is likely to be more detrimental to older adults’ physical and emotional health. This study examined the implications of the two kinds of network members for physical and psychological health and interpersonal coping responses in a representative sample of 916 older adults. Within this elderly sample, older age was associated with fewer ambivalent kin ties and fewer exclusively problematic kin ties. Analyses revealed that ambivalent social ties were more strongly related to functional health limitations than were exclusively problematic social ties, whereas problematic ties were more consistently related to psychological health than were ambivalent ties. Furthermore, negative exchanges that occurred with exclusively problematic social ties, as compared to those that occurred with ambivalent social ties, were associated with more avoidant and fewer conciliatory coping responses, stronger and longer-lasting negative emotions, and lower perceived coping effectiveness. A comprehensive understanding of the significance of social network ties in older adults’ lives may benefit not only from attention to sources of social support but also from efforts to distinguish between different sources of conflict and disappointment. PMID:22775360

Tie-fibre structure and organization in the knee menisci

PubMed Central

Andrews, Stephen H J; Rattner, Jerome B; Abusara, Ziad; Adesida, Adetola; Shrive, Nigel G; Ronsky, Janet L

2014-01-01

The collagenous structure of the knee menisci is integral to the mechanical integrity of the tissue and the knee joint. The tie-fibre structure of the tissue has largely been neglected, despite previous studies demonstrating its correlation with radial stiffness. This study has evaluated the structure of the tie-fibres of bovine menisci using 2D and 3D microscopy techniques. Standard collagen and proteoglycan (PG) staining and 2D light microscopy techniques were conducted. For the first time, the collagenous structure of the menisci was evaluated using 3D, second harmonic generation (SHG) microscopy. This technique facilitated the imaging of collagen structure in thick sections (50–100 μm). Imaging identified that tie-fibres of the menisci arborize from the outer margin of the meniscus toward the inner tip. This arborization is associated with the structural arrangement of the circumferential fibres. SHG microscopy has definitively demonstrated the 3D organization of tie-fibres in both sheets and bundles. The hierarchy of the structure is related to the organization of circumferential fascicles. Large tie-fibre sheets bifurcate into smaller sheets to surround circumferential fascicles of decreasing size. The tie-fibres emanate from the lamellar layer that appears to surround the entire meniscus. At the tibial and femoral surfaces these tie-fibre sheets branch perpendicularly into the meniscal body. The relationship between tie-fibres and blood vessels in the menisci was also observed in this study. Tie-fibre sheets surround the blood vessels and an associated PG-rich region. This subunit of the menisci has not previously been described. The size of tie-fibre sheets surrounding the vessels appeared to be associated with the size of blood vessel. These structural findings have implications in understanding the mechanics of the menisci. Further, refinement of the complex structure of the tie-fibres is important in understanding the consequences of injury and disease in the menisci. The framework of meniscus architecture also defines benchmarks for the development of tissue-engineered replacements in the future. PMID:24617800

Does Primary Productivity Turn Up the Volume? Exploring the Relationship Between Chlorophyll a and the Soundscape of Coral Reefs in the Pacific.

PubMed

Fisher-Pool, Pollyanna I; Lammers, Marc O; Gove, Jamison; Wong, Kevin B

2016-01-01

Chlorophyll is the basis for ecosystem productivity in most marine environments. We report on an ongoing effort to examine whether ambient sounds are tied to chlorophyll levels. We hypothesized that an increase in food-web available energy will be distributed across trophic levels, eventually reaching sound-producing animals and increasing acoustic levels. To test our hypothesis, we compared reef environments to explore links between soundscapes and chlorophyll a concentrations. The study sites resided in disparate oceanographic regimes that experienced substantially different oceanographic conditions. We anticipated that the results would show differing patterns of primary productivity between sites and therefore would be reflected in the soundscapes.

Deuterium Abundance Toward G191-B2B: Results from the Far Ultraviolet Spectroscopic Explorer (FUSE) Mission

NASA Technical Reports Server (NTRS)

Lemoine, M.; Vidal-Madjar, A.; Hebrard, G.; Desert, J.-M.; Ferlet, R.; LecavelierdesEtangs, A.; Howk, J. C.; Andre, M.; Blair, W. P.; Friedman, S. D.;

The swine flu vaccine, public attitudes, and researcher interpretations: a systematic review of qualitative research.

PubMed

Carlsen, Benedicte; Glenton, Claire

2016-06-24

During pandemics, health authorities may be uncertain about the spread and severity of the disease and the effectiveness and safety of available interventions. This was the case during the swine flu (H1N1) pandemic of 2009-2010, and governments were forced to make decisions despite these uncertainties. While many countries chose to implement wide scale vaccination programmes, few accomplished their vaccination goals. Many research studies aiming to explore barriers and facilitators to vaccine uptake have been conducted in the aftermath of the pandemic, including several qualitative studies. 1. To explore public attitudes to the swine flu vaccine in different countries through a review of qualitative primary studies. 2. To describe and discuss the implications drawn by the primary study authors. Systematic review of qualitative research studies, using a broadly comparative cross case-study approach. Study quality was appraised using an adaptation of the Critical Appraisal Skills Programme (CASP) quality assessment tool. The review indicates that the public had varying opinions about disease risk and prevalence and had concerns about vaccine safety. Most primary study authors concluded that participants were uninformed, and that more information about the disease and the vaccine would have led to an increase in vaccine uptake. We find these conclusions problematic. We suggest instead that people's questions and concerns were legitimate given the uncertainties of the situation at the time and the fact that the authorities did not have the necessary information to convince the public. Our quality assessment of the included studies points to a lack of reflexivity and a lack of information about study context. We suggest that these study weaknesses are tied to primary study authors' lack of acknowledgement of the uncertainties surrounding the disease and the vaccine. While primary study authors suggest that authorities could increase vaccine uptake through increased information, we suggest instead that health authorities should be more transparent in their information and decision-making processes in future pandemic situations.

Who Can You Turn to? Tie Activation within Core Business Discussion Networks

ERIC Educational Resources Information Center

Renzulli, Linda A.; Aldrich, Howard

2005-01-01

We examine the connection between personal network characteristics and the activation of ties for access to resources during routine times. We focus on factors affecting business owners' use of their core network ties to obtain legal, loan, financial and expert advice. Owners rely more on core business ties when their core networks contain a high…

78 FR 75544 - Prestressed Concrete Steel Rail Tie Wire From Mexico: Preliminary Determination of Sales at Less...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-12

... Rail Tie Wire From Mexico: Preliminary Determination of Sales at Less Than Fair Value and Postponement...'') preliminarily determines that prestressed concrete steel rail tie wire (``PC tie wire'') from Mexico is being... covered by this investigation is high carbon steel wire; stress relieved or low relaxation; indented or...

78 FR 57619 - Prestressed Concrete Steel Rail Tie Wire From Mexico, Thailand, and the People's Republic of...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-09-19

...] Prestressed Concrete Steel Rail Tie Wire From Mexico, Thailand, and the People's Republic of China... prestressed concrete steel rail tie wire from Mexico, Thailand, and the People's Republic of China. See Prestressed Concrete Steel Rail Tie Wire From Mexico, the People's Republic of China, and Thailand: Initiation...

The role of rewarding and novel events in facilitating memory persistence in a separate spatial memory task.

PubMed

Salvetti, Beatrice; Morris, Richard G M; Wang, Szu-Han

2014-01-15

Many insignificant events in our daily life are forgotten quickly but can be remembered for longer when other memory-modulating events occur before or after them. This phenomenon has been investigated in animal models in a protocol in which weak memories persist longer if exploration in a novel context is introduced around the time of memory encoding. This study aims to understand whether other types of rewarding or novel tasks, such as rewarded learning in a T-maze and novel object recognition, can also be effective memory-modulating events. Rats were trained in a delayed matching-to-place task to encode and retrieve food locations in an event arena. Weak encoding with only one food pellet at the sample location induced memory encoding but forgetting over 24 h. When this same weak encoding was followed by a rewarded task in a T-maze, the memory persisted for 24 h. Moreover, the same persistence of memory over 24 h could be achieved by exploration in a novel box or by a rewarded T-maze task after a "non-rewarded" weak encoding. When the one-pellet weak encoding was followed by novel object exploration, the memory did not persist at 24 h. Together, the results confirm that place encoding is possible without explicit reward, and that rewarded learning in a separate task lacking novelty can be an effective memory-modulating event. The behavioral and neurobiological implications are discussed.

Sharing motherhood: maternal jealousy among lesbian co-mothers.

PubMed

Pelka, Suzanne

2009-01-01

Previous research has not adequately addressed how gay and lesbian couples emotionally negotiate unequal biological ties to their children. Because each co-parent has the potential to be their child's biological parent and because same-sex couples highly value relationship equality, unequal biological ties to children may cause feelings of jealousy between co-parents. To counter this, increasing numbers of lesbian couples have been using in-vitro fertilization (IVF) to biologically co-mother, using the eggs of one partner and the womb of the other. While hardly common, this strategy can affect the emotional dynamics between the co-mothers and their children. This article explores how variables common to many lesbian-led families (including method of conception) may contribute to or protect against jealousy. Presented data comes from an 18-month ethnographic study of 30 lesbian-led families with young children living in a major northeastern city. Ten couples adopted infants, 10 couples used assisted insemination (AI), and 10 couples used IVF to biologically co-mother. Lesbians' use of IVF to co-mother has not been previously studied. Methods included in-depth interviews, participant observation, and self-administered questionnaires. Couples who adopted or used IVF reported less jealousy than couples who conceived using AI. Factors that correlate with the likelihood of experiencing maternal jealousy include both partners wanting to be a birth mother, perceptions of unequal biological ties to children, and infertility. Professionals serving lesbian co-mothers should be sensitive to the presence and absence of the above factors.

Utilizing combinatorial engineering to develop Tie2 targeting antagonistic angiopoetin-2 ligands as candidates for anti-angiogenesis therapy.

PubMed

Shlamkovich, Tomer; Aharon, Lidan; Barton, William A; Papo, Niv

2017-05-16

In many human cancers, the receptor tyrosine kinase (RTK) Tie2 plays important roles in mediating proliferation, survival, migration and angiogenesis. Thus, molecules that could potently inhibit activation of the Tie2 receptor would have a significant impact on cancer therapy. Nevertheless, attempts to develop Tie2-targeted inhibitors have met with little success, and there is currently no FDA-approved therapeutic selectively targeting Tie2. We used a combinatorial protein engineering approach to develop a new generation of angiopoietin (Ang)2-derived Tie2 antagonists as potential cancer therapeutics and as tools to study angiogenesis. The construct for designing a yeast surface display (YSD) library of potential antagonists was an Ang2 binding domain (Ang2-BD) that retains Tie2 binding ability but prevents ligand multimerization and receptor dimerization and activation. This mutant library was then screened by quantitative high-throughput flow cytometric sorting to identify Ang2-BD variants with increased expression, stability and affinity to Tie2. The selected variants were recombinantly expressed and showed high affinity to soluble and cellular Tie2 and strongly inhibited both Tie2 phosphorylation and endothelial capillary tube formation and cell invasion compared to the parental Ang2-BD. The significance of the study lies in the insight it provides into the sequence-structure-function relationships and mechanism of action of the antagonistic Ang mutants. The approach of using a natural protein ligand as a molecular scaffold for engineering high-affinity agents can be applied to other ligands to create functional protein antagonists against additional biomedical targets.

A longitudinal examination of the bidirectional association between sleep problems and social ties at university: the mediating role of emotion regulation.

PubMed

Tavernier, Royette; Willoughby, Teena

2015-02-01

Despite the growing body of research linking sleep problems and social ties, research investigating the direction of effects between these two constructs is lacking. Furthermore, there remains a dearth of research examining the mechanisms that may explain the association between sleep problems and social ties within a longitudinal design. The present 3-year longitudinal study addressed two research questions: (1) Is there a bidirectional association between sleep problems and social ties at university? and (2) Does emotion regulation mediate the association between sleep problems and social ties at university? Participants (N = 942, 71.5% female; M = 19.01 years at Time 1, SD = 0.90) were university students who completed annual assessments of sleep problems, social ties, and emotion regulation, for three consecutive years. Results of path analysis indicated that the bidirectional association between sleep problems and social ties was statistically significant (controlling for demographics, sleep-wake inconsistency, sleep duration, and alcohol). Analyses of indirect effects indicated that emotion regulation mediated this link, such that better sleep quality (i.e., less sleep problems) led to more effective emotion regulation, which, subsequently, led to more positive social ties. In addition, more positive social ties led to more effective emotion regulation, which, in turn, led to less sleep problems. The findings highlight the critical role that emotional regulation plays in the link between sleep problems and social ties, and emphasize the need for students as well as university administration to pay close attention to both the sleep and social environment of university students.

Recovery from radiation-induced bone marrow damage by HSP25 through Tie2 signaling.

PubMed

Lee, Hae-June; Kwon, Hee-Chung; Chung, Hee-Yong; Lee, Yoon-Jin; Lee, Yun-Sil

2012-09-01

Whole-body radiation therapy can cause severe injury to the hematopoietic system, and therefore it is necessary to identify a novel strategy for overcoming this injury. Mice were irradiated with 4.5 Gy after heat shock protein 25 (HSP25) gene transfer using an adenoviral vector. Then, peripheral blood cell counts, histopathological analysis, and Western blotting on bone marrow (BM) cells were performed. The interaction of HSP25 with Tie2 was investigated with mouse OP9 and human BM-derived mesenchymal stem cells to determine the mechanism of HSP25 in the hematopoietic system. HSP25 transfer increased BM regeneration and reduced apoptosis following whole-body exposure to ionizing radiation (IR). The decrease in Tie2 protein expression that followed irradiation of the BM was blocked by HSP25 transfer, and Tie2-positive cells were more abundant among the BM cells of HSP25-transferred mice, even after IR exposure. Following systemic RNA interference of Tie2 before IR, HSP25-mediated radioprotective effects were partially blocked in both mice and cell line systems. Stability of Tie2 was increased by HSP25, a response mediated by the interaction of HSP25 with Tie2. IR-induced tyrosine phosphorylation of Tie2 was augmented by HSP25 overexpression; downstream events in the Tie2 signaling pathway, including phosphorylation of AKT and EKR1/2, were also activated. HSP25 protects against radiation-induced BM damage by interacting with and stabilizing Tie2. This may be a novel strategy for HSP25-mediated radioprotection in BM. Copyright © 2012 Elsevier Inc. All rights reserved.

The Weak Stability Boundary, A Gateway for Human Exploration of Space

NASA Technical Reports Server (NTRS)

Mendell, Wendell W.

2000-01-01

NASA plans for future human exploration of the Solar System describe only missions to Mars. Before such missions can be initiated, much study remains to be done in technology development, mission operations and human performance. While, for example, technology validation and operational experience could be gained in the context of lunar exploration missions, a NASA lunar program is seen as a competitor to a Mars mission rather than a step towards it. The recently characterized Weak Stability Boundary in the Earth-Moon gravitational field may provide an operational approach to all types of planetary exploration, and infrastructure developed for a gateway to the Solar System may be a programmatic solution for exploration that avoids the fractious bickering between Mars and Moon advocates. This viewpoint proposes utilizing the concept of Greater Earth to educate policy makers, opinion makers and the public about these subtle attributes of our space neighborhood.

Evolution of Bow-Tie Architectures in Biology

PubMed Central

Friedlander, Tamar; Mayo, Avraham E.; Tlusty, Tsvi; Alon, Uri

2015-01-01

Bow-tie or hourglass structure is a common architectural feature found in many biological systems. A bow-tie in a multi-layered structure occurs when intermediate layers have much fewer components than the input and output layers. Examples include metabolism where a handful of building blocks mediate between multiple input nutrients and multiple output biomass components, and signaling networks where information from numerous receptor types passes through a small set of signaling pathways to regulate multiple output genes. Little is known, however, about how bow-tie architectures evolve. Here, we address the evolution of bow-tie architectures using simulations of multi-layered systems evolving to fulfill a given input-output goal. We find that bow-ties spontaneously evolve when the information in the evolutionary goal can be compressed. Mathematically speaking, bow-ties evolve when the rank of the input-output matrix describing the evolutionary goal is deficient. The maximal compression possible (the rank of the goal) determines the size of the narrowest part of the network—that is the bow-tie. A further requirement is that a process is active to reduce the number of links in the network, such as product-rule mutations, otherwise a non-bow-tie solution is found in the evolutionary simulations. This offers a mechanism to understand a common architectural principle of biological systems, and a way to quantitate the effective rank of the goals under which they evolved. PMID:25798588

The evolution of prompt reaction to adverse ties.

PubMed

Van Segbroeck, Sven; Santos, Francisco C; Nowé, Ann; Pacheco, Jorge M; Lenaerts, Tom

2008-10-17

In recent years it has been found that the combination of evolutionary game theory with population structures modelled in terms of dynamical graphs, in which individuals are allowed to sever unwanted social ties while keeping the good ones, provides a viable solution to the conundrum of cooperation. It is well known that in reality individuals respond differently to disadvantageous interactions. Yet, the evolutionary mechanism determining the individuals' willingness to sever unfavourable ties remains unclear. We introduce a novel way of thinking about the joint evolution of cooperation and social contacts. The struggle for survival between cooperators and defectors leads to an arms race for swiftness in adjusting social ties, based purely on a self-regarding, individual judgement. Since defectors are never able to establish social ties under mutual agreement, they break adverse ties more rapidly than cooperators, who tend to evolve stable and long-term relations. Ironically, defectors' constant search for partners to exploit leads to heterogeneous networks that improve the survivability of cooperators, compared to the traditional homogenous population assumption. When communities face the prisoner's dilemma, swift reaction to adverse ties evolves when competition is fierce between cooperators and defectors, providing an evolutionary basis for the necessity of individuals to adjust their social ties. Our results show how our innate resilience to change relates to mutual agreement between cooperators and how "loyalty" or persistent social ties bring along an evolutionary disadvantage, both from an individual and group perspective.

Tie2 signaling cooperates with TNF to promote the pro-inflammatory activation of human macrophages independently of macrophage functional phenotype.

PubMed

García, Samuel; Krausz, Sarah; Ambarus, Carmen A; Fernández, Beatriz Malvar; Hartkamp, Linda M; van Es, Inge E; Hamann, Jörg; Baeten, Dominique L; Tak, Paul P; Reedquist, Kris A

2014-01-01

Angiopoietin (Ang) -1 and -2 and their receptor Tie2 play critical roles in regulating angiogenic processes during development, homeostasis, tumorigenesis, inflammation and tissue repair. Tie2 signaling is best characterized in endothelial cells, but a subset of human and murine circulating monocytes/macrophages essential to solid tumor formation express Tie2 and display immunosuppressive properties consistent with M2 macrophage polarization. However, we have recently shown that Tie2 is strongly activated in pro-inflammatory macrophages present in rheumatoid arthritis patient synovial tissue. Here we examined the relationship between Tie2 expression and function during human macrophage polarization. Tie2 expression was observed under all polarization conditions, but was highest in IFN-γ and IL-10 -differentiated macrophages. While TNF enhanced expression of a common restricted set of genes involved in angiogenesis and inflammation in GM-CSF, IFN-γ and IL-10 -differentiated macrophages, expression of multiple chemokines and cytokines, including CXCL3, CXCL5, CXCL8, IL6, and IL12B was further augmented in the presence of Ang-1 and Ang-2, via Tie2 activation of JAK/STAT signaling. Conditioned medium from macrophages stimulated with Ang-1 or Ang-2 in combination with TNF, sustained monocyte recruitment. Our findings suggest a general role for Tie2 in cooperatively promoting the inflammatory activation of macrophages, independently of polarization conditions.

Neural dynamics of social tie formation in economic decision-making.

PubMed

Bault, Nadège; Pelloux, Benjamin; Fahrenfort, Johannes J; Ridderinkhof, K Richard; van Winden, Frans

2015-06-01

The disposition for prosocial conduct, which contributes to cooperation as arising during social interaction, requires cortical network dynamics responsive to the development of social ties, or care about the interests of specific interaction partners. Here, we formulate a dynamic computational model that accurately predicted how tie formation, driven by the interaction history, influences decisions to contribute in a public good game. We used model-driven functional MRI to test the hypothesis that brain regions key to social interactions keep track of dynamics in tie strength. Activation in the medial prefrontal cortex (mPFC) and posterior cingulate cortex tracked the individual's public good contributions. Activation in the bilateral posterior superior temporal sulcus (pSTS), and temporo-parietal junction was modulated parametrically by the dynamically developing social tie-as estimated by our model-supporting a role of these regions in social tie formation. Activity in these two regions further reflected inter-individual differences in tie persistence and sensitivity to behavior of the interaction partner. Functional connectivity between pSTS and mPFC activations indicated that the representation of social ties is integrated in the decision process. These data reveal the brain mechanisms underlying the integration of interaction dynamics into a social tie representation which in turn influenced the individual's prosocial decisions. © The Author (2014). Published by Oxford University Press. For Permissions, please email: journals.permissions@oup.com.

Stepfamily Formation: Implications for Adolescent Ties to Mothers, Nonresident Fathers, and Stepfathers

ERIC Educational Resources Information Center

King, Valarie

2009-01-01

This study examines how the entrance of a stepfather influences adolescent ties to mothers and nonresident fathers and how prior ties to each biological parent influence the development of stepfather-stepchild ties. Data come from 1,753 adolescents in the National Longitudinal Study of Adolescent Health who lived with a single mother in Wave 1 who…

Social capital and core network ties: a validation study of individual-level social capital measures and their association with extra- and intra-neighborhood ties, and self-rated health.

PubMed

Moore, Spencer; Bockenholt, Ulf; Daniel, Mark; Frohlich, Katherine; Kestens, Yan; Richard, Lucie

2011-03-01

Research on social capital and health has assumed that measures of trust, participation, and perceived cohesion capture aspects of people's neighborhood social connections. This study uses data on the personal networks of 2707 Montreal adults in 300 different neighborhoods to examine the association of socio-demographic and social capital variables with the likelihood of having core ties, core neighborhood ties, and high self-rated health (SRH). Persons with higher household income were more likely to have core ties, but less likely to have core neighborhood ties. Persons with greater diversity in extra-neighborhood network capital were more likely to have core ties, and persons with greater diversity in intra-neighborhood network capital were more likely to have core neighborhood ties. Generalized trust, perceived neighborhood cohesion, and extra-neighborhood network diversity were shown associated with high SRH. Conventional measures of social capital may not capture network mechanisms. Findings suggest a critical appraisal of the mechanisms linking social capital and health, and the further delineation of network and psychosocial mechanisms in understanding these links. Copyright © 2010 Elsevier Ltd. All rights reserved.

Exploration of Advanced Probabilistic and Stochastic Design Methods

NASA Technical Reports Server (NTRS)

Mavris, Dimitri N.

2003-01-01

The primary objective of the three year research effort was to explore advanced, non-deterministic aerospace system design methods that may have relevance to designers and analysts. The research pursued emerging areas in design methodology and leverage current fundamental research in the area of design decision-making, probabilistic modeling, and optimization. The specific focus of the three year investigation was oriented toward methods to identify and analyze emerging aircraft technologies in a consistent and complete manner, and to explore means to make optimal decisions based on this knowledge in a probabilistic environment. The research efforts were classified into two main areas. First, Task A of the grant has had the objective of conducting research into the relative merits of possible approaches that account for both multiple criteria and uncertainty in design decision-making. In particular, in the final year of research, the focus was on the comparison and contrasting between three methods researched. Specifically, these three are the Joint Probabilistic Decision-Making (JPDM) technique, Physical Programming, and Dempster-Shafer (D-S) theory. The next element of the research, as contained in Task B, was focused upon exploration of the Technology Identification, Evaluation, and Selection (TIES) methodology developed at ASDL, especially with regards to identification of research needs in the baseline method through implementation exercises. The end result of Task B was the documentation of the evolution of the method with time and a technology transfer to the sponsor regarding the method, such that an initial capability for execution could be obtained by the sponsor. Specifically, the results of year 3 efforts were the creation of a detailed tutorial for implementing the TIES method. Within the tutorial package, templates and detailed examples were created for learning and understanding the details of each step. For both research tasks, sample files and tutorials are attached in electronic form with the enclosed CD.

Managing Requirements-Documents to Data

NASA Technical Reports Server (NTRS)

Orr, Kevin; Hudson, Abe

2017-01-01

Managing Requirements on long term projects like International Space Station (ISS) can go thru many phases, from initial product development to almost over 20 years of operations and sustainment. Over that time many authorized changes have been made to the requirement set, that apply to any new systems that would visit the ISS today, like commercial cargo/crew vehicles or payloads. Explore the benefits of managing requirements in a database while satisfying traditional documents needs for contracts and stakeholder/user consumption that are not tied into the database.

Preparing future space leaders - International Space University

NASA Technical Reports Server (NTRS)

Stone, Barbara A.; Van Reeth, George P.

1992-01-01

The International Space University (ISU) concept of developing a cadre of space professionals that will lead the universities and industries into space is discussed. ISU is an innovative, permanent worldwide organization for training and academic instruction in all aspects of space studies. ISU's major goal is to provide the young professional academic instruction in technical and nontechnical areas of modern space exploration and research, and a forum to exchange ideas and develop both personal and professional ties at an international level.

Do online gossipers promote brands?

PubMed

Okazaki, Shintaro; Rubio, Natalia; Campo, Sara

2013-02-01

Online gossip has been recognized as small talk on social networking sites (SNSs) that influences consumer behavior, but little attention has been paid to its role. This study makes three theoretical predictions: (a) propensity to gossip online leads to greater information value, entertainment value, and friendship value; (b) upon exposure to a high-involvement product, online gossipers are more willing to spread such information through electronic word-of-mouth (eWOM) in search of prestige or fame as a knowledge expert; and (c) this tendency will be more pronounced when they are connected with strong ties (rather than weak ties) and belong to a large network (rather than a small network). An experimental survey was conducted with a scenario method. In total, 818 general consumers participated in the survey. A multivariate analysis of variance (ANOVA) provides empirical support for prediction (1). With regard to predictions (2) and (3), a series of three-way and two-way between-subjective ANOVAs were performed. When a high-involvement product is promoted, gossipers, rather than nongossipers, are more willing to participate in eWOM on an SNS. Furthermore, a significant interaction effect indicates that online gossipers' willingness to particiapte in eWOM would be more pronounced if they belonged to a large network rather than a small network. However, when a low-involvement product is promoted, no interaction effect is found between online gossip and network size. In closing, theoretical and managerial implications are discussed, while important limitations are recognized.

Do Online Gossipers Promote Brands?

PubMed Central

Rubio, Natalia; Campo, Sara

2013-01-01

Abstract Online gossip has been recognized as small talk on social networking sites (SNSs) that influences consumer behavior, but little attention has been paid to its role. This study makes three theoretical predictions: (a) propensity to gossip online leads to greater information value, entertainment value, and friendship value; (b) upon exposure to a high-involvement product, online gossipers are more willing to spread such information through electronic word-of-mouth (eWOM) in search of prestige or fame as a knowledge expert; and (c) this tendency will be more pronounced when they are connected with strong ties (rather than weak ties) and belong to a large network (rather than a small network). An experimental survey was conducted with a scenario method. In total, 818 general consumers participated in the survey. A multivariate analysis of variance (ANOVA) provides empirical support for prediction (1). With regard to predictions (2) and (3), a series of three-way and two-way between-subjective ANOVAs were performed. When a high-involvement product is promoted, gossipers, rather than nongossipers, are more willing to participate in eWOM on an SNS. Furthermore, a significant interaction effect indicates that online gossipers' willingness to particiapte in eWOM would be more pronounced if they belonged to a large network rather than a small network. However, when a low-involvement product is promoted, no interaction effect is found between online gossip and network size. In closing, theoretical and managerial implications are discussed, while important limitations are recognized. PMID:23276259

Does frenotomy improve breast-feeding difficulties in infants with ankyloglossia?

PubMed

Ito, Yasuo

2014-08-01

The aim of this systematic review was to critically examine the existing literature regarding the effectiveness of tongue-tie division in infants with ankyloglossia, using the new grades of recommendations, assessment, development, and evaluation (GRADE) rating system. A clinical question was structured according to patient, intervention, comparison, and outcome, as follows: in infants with poor breast-feeding and ankyloglossia (patient), does frenotomy (intervention), compared to lactation support alone (comparison), improve feeding (outcome)? An electronic literature search was systematically conducted from databases including PubMed, Japana Centra Revuo Medicina (Igaku Chuo Zasshi), CINAHL, and Cochrane Library using the key words "ankyloglossia," "tongue-tie," "frenotomy," and/or "breast-feeding" in English and equivalent terms in Japanese. The literature search yielded four randomized clinical trials, and 12 observational studies for analysis. The quality of the literature was rated in regard to the two most important outcomes (sucking/latching, and nipple pain) and five less important outcomes (milk supply/milk production, continuation of breast-feeding, weight gain, adverse events, and dyad distress) in accordance with the GRADE system. Evidence levels of the most important outcomes were rated either A (strong evidence) or B (moderate evidence), and less important outcomes were rated C (weak evidence); every outcome consistently showed a favorable effect of frenotomy on breast-feeding. The literature review supported an overall moderate quality of evidence for the effectiveness of frenotomy for the treatment of breast-feeding difficulties in infants with ankyloglossia. No major complications from frenotomy were reported. © 2014 Japan Pediatric Society.

Relations Between Neighborhood Factors, Parenting Behaviors, Peer Deviance, and Delinquency Among Serious Juvenile Offenders

PubMed Central

Chung, He Len; Steinberg, Laurence

2009-01-01

The present study examined relations among neighborhood structural and social characteristics, parenting practices, peer group affiliations, and delinquency among a group of serious adolescent offenders. The sample of 14–18-year-old boys (N = 488) was composed primarily of economically disadvantaged, ethnic-minority youth living in urban communities. The results indicate that weak neighborhood social organization is indirectly related to delinquency through its associations with parenting behavior and peer deviance and that a focus on just 1 of these microsystems can lead to oversimplified models of risk for juvenile offending. The authors also find that community social ties may confer both pro- and antisocial influences to youth, and they advocate for a broad conceptualization of neighborhood social processes as these relate to developmental risk for youth living in disadvantaged communities. PMID:16569170

Epidemics on interconnected networks

NASA Astrophysics Data System (ADS)

Dickison, Mark; Havlin, S.; Stanley, H. E.

2012-06-01

Populations are seldom completely isolated from their environment. Individuals in a particular geographic or social region may be considered a distinct network due to strong local ties but will also interact with individuals in other networks. We study the susceptible-infected-recovered process on interconnected network systems and find two distinct regimes. In strongly coupled network systems, epidemics occur simultaneously across the entire system at a critical infection strength βc, below which the disease does not spread. In contrast, in weakly coupled network systems, a mixed phase exists below βc of the coupled network system, where an epidemic occurs in one network but does not spread to the coupled network. We derive an expression for the network and disease parameters that allow this mixed phase and verify it numerically. Public health implications of communities comprising these two classes of network systems are also mentioned.

Monthly AOD maps combining strengths of remote sensing products

NASA Astrophysics Data System (ADS)

Kinne, Stefan

2010-05-01

The mid-visible aerosol optical depth (AOD) is the most prominent property to quantify aerosol amount the atmospheric column. Almost all aerosol retrievals of satellite sensors provide estimates for this property, however, often with limited success. As sensors differ in capabilities individual retrievals have local and regional strengths and weaknesses. Focusing on individual retrieval strengths a satellite based AOD composite has been constructed. Hereby, every retrieval performance has been assessed in statistical comparisons to ground-based sun-photometry, which provide highly accurate references though only at few globally distributed monitoring sites. Based on these comparisons, which consider bias as well as spatial patterns and seasonality, the regionally best performing satellite AOD products are combined. The resulting remote sensing AOD composite provide a general reference for the spatial and temporal AOD distribution on an (almost) global basis - solely tied to sensor data.

Commentary on: Are we overpathologizing everyday life? A tenable blueprint for behavioral addiction research. Addictions as a psychosocial and cultural construction.

PubMed

van der Linden, Martial

2015-09-01

This commentary proposes a complementary perspective to that developed by Billieux, Schimmenti, Khazaal, Maurage and Heeren (2015). The addiction-as-disease approach tends to sideline explanatory factors of a psychosocial, cultural, political, or historical nature. I therefore suggest taking into account not only the personal characteristics (loss of self-control, impulsivity) related to the disease model, but also the social determinants of addictive behaviors (weak social ties, social exclusion, hyperindividualism, poverty, unemployment, etc.). Moreover, the disease model of addiction removes addictive behaviors from the cultural and historical contexts that shape them. I argue that the cultural and historical reasons for which certain factors (such as loss of self-control) became so important in the explanation of addictive behaviors should be more thoroughly considered.

New Instability Mode in A Driven Granular Gas: Athermal and Thermal Convection

NASA Astrophysics Data System (ADS)

Shukla, Priyanka; Alam, Meheboob

2017-11-01

For a thermally-driven granular gas confined between two plates under gravity, we report a new instability mode which is found to be active at very small values of the heat-loss parameter. We show that the origin of this new mode is tied to the ``thermal'' mode of the well-studied Rayleigh-Benard convection. This is dubbed purely elastic instability since it survives even for perfectly elastic collisions (en = 1). The distinction of this new instability mode from its dissipative/athermal counterpart is clarified for the first time. Furthermore, a weakly nonlinear analysis using Stuart-Landau equation has been carried out for both instability modes, and the underlying bifurcation scenario (supercritical/subcritical) from each mode is elucidated. The resulting linear and nonlinear patterns with respect to inelasticity and gravity are compared.

Socioeconomic determinants of health: community marginalisation and the diffusion of disease and disorder in the United States.

PubMed Central

Wallace, R.; Wallace, D.

1997-01-01

This article describes the cascading diffusion of "inner city problems" of disease and disorder in the United States--from the huge marginalised inner city communities of the largest municipalities, first along national travel routes to smaller cities, and then from central cities into surrounding more affluent suburbs-following the pattern of the daily journey to work. Public policies and economic practices which increase marginalisation act to damage the "weak ties" of the community social networks which bind central city neighbourhoods into functioning units. Spreading disease and disorder can be interpreted as indices of the resulting social disintegration, which is driven by policy. This "failure of containment" in the United States should serve as a warning for cities in Europe against reducing the municipal and other services that they provide to "unpopular" subpopulations. PMID:9158474

49 CFR 195.308 - Testing of tie-ins.

Code of Federal Regulations, 2010 CFR

2010-10-01

... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Pressure Testing § 195.308 Testing of tie-ins. Pipe associated with tie-ins must be pressure...

49 CFR 195.308 - Testing of tie-ins.

Code of Federal Regulations, 2011 CFR

2011-10-01

... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Pressure Testing § 195.308 Testing of tie-ins. Pipe associated with tie-ins must be pressure...

49 CFR 195.308 - Testing of tie-ins.

Code of Federal Regulations, 2012 CFR

2012-10-01

... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Pressure Testing § 195.308 Testing of tie-ins. Pipe associated with tie-ins must be pressure...

49 CFR 195.308 - Testing of tie-ins.

Code of Federal Regulations, 2013 CFR

2013-10-01

... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Pressure Testing § 195.308 Testing of tie-ins. Pipe associated with tie-ins must be pressure...

49 CFR 195.308 - Testing of tie-ins.

Code of Federal Regulations, 2014 CFR

2014-10-01

... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY TRANSPORTATION OF HAZARDOUS LIQUIDS BY PIPELINE Pressure Testing § 195.308 Testing of tie-ins. Pipe associated with tie-ins must be pressure...

27 CFR 6.72 - “Tie-in” sales.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false âTie-inâ sales. 6.72 Section 6.72 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY LIQUORS âTIED-HOUSEâ Unlawful Inducements Quota Sales § 6.72 “Tie-in” sales. The act by an industry member of requiring that a...

A Critique of Behavioral Psychotherapy: The Groundwork for an Integrated Model of Intervention.

ERIC Educational Resources Information Center

Wright, John; Sabourin, Stephane

1984-01-01

Discusses several strengths and weaknesses of the behavioral approach in psychotherapy. Possible remediation of some of the weaknesses are explored through integration of contributions from client-centered or psychodynamic approaches. Risks associated with an integrated model of psychotherapy are considered. (Author)

The Arabidopsis RING-Type E3 Ligase TEAR1 Controls Leaf Development by Targeting the TIE1 Transcriptional Repressor for Degradation[OPEN

PubMed Central

Zhang, Jinzhe; Wei, Baoye; Yuan, Rongrong; Yu, Hao

2017-01-01

The developmental plasticity of leaf size and shape is important for leaf function and plant survival. However, the mechanisms by which plants form diverse leaves in response to environmental conditions are not well understood. Here, we identified TIE1-ASSOCIATED RING-TYPE E3 LIGASE1 (TEAR1) and found that it regulates leaf development by promoting the degradation of TCP INTERACTOR-CONTAINING EAR MOTIF PROTEIN1 (TIE1), an important repressor of CINCINNATA (CIN)-like TEOSINTE BRANCHED1/CYCLOIDEA/PCF (TCP) transcription factors, which are key for leaf development. TEAR1 contains a typical C3H2C3-type RING domain and has E3 ligase activity. We show that TEAR1 interacts with the TCP repressor TIE1, which is ubiquitinated in vivo and degraded by the 26S proteasome system. We demonstrate that TEAR1 is colocalized with TIE1 in nuclei and negatively regulates TIE1 protein levels. Overexpression of TEAR1 rescued leaf defects caused by TIE1 overexpression, whereas disruption of TEAR1 resulted in leaf phenotypes resembling those caused by TIE1 overexpression or TCP dysfunction. Deficiency in TEAR partially rescued the leaf defects of TCP4 overexpression line and enhanced the wavy leaf phenotypes of jaw-5D. We propose that TEAR1 positively regulates CIN-like TCP activity to promote leaf development by mediating the degradation of the TCP repressor TIE1. PMID:28100709

The evolution of prompt reaction to adverse ties

PubMed Central

2008-01-01

Background In recent years it has been found that the combination of evolutionary game theory with population structures modelled in terms of dynamical graphs, in which individuals are allowed to sever unwanted social ties while keeping the good ones, provides a viable solution to the conundrum of cooperation. It is well known that in reality individuals respond differently to disadvantageous interactions. Yet, the evolutionary mechanism determining the individuals' willingness to sever unfavourable ties remains unclear. Results We introduce a novel way of thinking about the joint evolution of cooperation and social contacts. The struggle for survival between cooperators and defectors leads to an arms race for swiftness in adjusting social ties, based purely on a self-regarding, individual judgement. Since defectors are never able to establish social ties under mutual agreement, they break adverse ties more rapidly than cooperators, who tend to evolve stable and long-term relations. Ironically, defectors' constant search for partners to exploit leads to heterogeneous networks that improve the survivability of cooperators, compared to the traditional homogenous population assumption. Conclusion When communities face the prisoner's dilemma, swift reaction to adverse ties evolves when competition is fierce between cooperators and defectors, providing an evolutionary basis for the necessity of individuals to adjust their social ties. Our results show how our innate resilience to change relates to mutual agreement between cooperators and how "loyalty" or persistent social ties bring along an evolutionary disadvantage, both from an individual and group perspective. PMID:18928551

The pre-college teaching of geosciences in the USA

NASA Astrophysics Data System (ADS)

Stewart, R.

2003-04-01

Most students in the USA learn about the earth in elementary and middle school, with most of the learning in middle schools (students who are 12 to 15 years old). A few students study geosciences in high school (ages 15 to 19). In some states, for example Texas, the high-school courses are being de-emphasized, and very few students take geoscience courses after they are 15 years old. As a result, most high-school graduates know little about such important issues as global warming, air pollution, or water quality. In the USA, the geoscience curriculum is guided by national and state standards for teaching mathematics and science. But the guidance is weak. Curricula are determined essentially by local school boards and teachers with some overview by state governments. For example, the State of Texas requires all students to pass standardized examinations in science at grades 5,10, and 11. The tests are based on the Texas Essential Knowledge and Skills, the state's version of the national standards. The teaching of the geosciences, especially oceanography, is hindered by the weak guidance provided by the national standards. Because of the lack of strong guidance, textbooks include far too much material with very weak ties between the geosciences. As a result, students learn many disconnected facts, not earth system science. Improvements in the teaching of the geosciences requires a clear statement of the important in the geosciences. Why must they be taught? What must be taught? What are the major themes of geoscience research? What is important for all to know?

Neighborhoods and Intimate Partner Violence Against Women: The Direct and Interactive Effects of Social Ties and Collective Efficacy.

PubMed

Wright, Emily M; Skubak Tillyer, Marie

2017-06-01

This study examines the impact of several indicators of neighborhood social ties (e.g., residents' interactions with each other; residents' ability to recognize outsiders) on intimate partner violence (IPV) against women as well as whether neighborhood collective efficacy's impact on IPV is contingent upon such ties. This study used data from 4,151 women (46% Latina, 33% African American, 17% Caucasian, on average 32 years old) in 80 neighborhoods from the Project on Human Development in Chicago Neighborhoods. We estimated a series of random effects hierarchical Bernoulli models to assess the main and interactive effects of neighborhood social ties and collective efficacy on minor and severe forms of IPV against women. Results indicate that certain neighborhood social ties are associated with higher rates of minor forms of IPV against women (but not severe forms of IPV), and collective efficacy does not appear to influence IPV against women, regardless of the level of individual or neighborhood social ties. Unlike street crime, collective efficacy does not significantly reduce IPV against women, even in neighborhoods with strong social ties that may facilitate awareness of the violence. In fact, perpetrators of minor IPV may enjoy some protective benefit in communities with social ties that make neighbors hesitant to intervene in what some might perceive as "private matters."

Role of intratumoral infiltrating macrophages after transarterial immunoembolization for hepatocellular carcinoma.

PubMed

Kenjo, Akira; Sato, Tetsu; Marubashi, Shigeru; Saito, Takuro; Tsuchiya, Takao; Kimura, Takashi; Sato, Naoya; Takahashi, Atsushi; Ohira, Hiromasa; Gotoh, Mitsukazu

2016-05-01

Preoperative transarterial immunoembolization (TIE) for hepatocellular carcinoma (HCC) is effective for preventing recurrence. We aimed to investigate the intratumoral and peritumoral M1 macrophage-induced immune response following TIE treatment. We compared 13 patients treated with TIE between 2003 and 2009 (TIE group) and 13 patients treated with surgery alone during the same period of time at our institute (control group) using an immunohistological study with CD68 and CD163 antibodies. No significant differences in clinicopathological characteristics, except for surgical time, were observed between the two groups. The 3-year recurrence-free survival outcome of the TIE group was quite different from that of the control group (100% vs. 38.5%, P = 0.034). In the histological investigation, lytic necrosis and coagulation necrosis of the main tumor along with the presence of multinuclear giant cells were observed in 10 of the 13 patients in the TIE group. The immunohistological study showed that not only the numbers of intratumoral CD68(+) cells, but also the numbers of intratumoral and peritumoral CD8(+) cells were significantly increased in the TIE group. The suppression of tumor recurrence induced by preoperative TIE might be induced by intratumoral M1 macrophages that are activated by OK-432 and fibrinogen. © 2016 Japanese Society of Hepato-Biliary-Pancreatic Surgery.

The TIE1 Transcriptional Repressor Links TCP Transcription Factors with TOPLESS/TOPLESS-RELATED Corepressors and Modulates Leaf Development in Arabidopsis[W

PubMed Central

Tao, Qing; Guo, Dongshu; Wei, Baoye; Zhang, Fan; Pang, Changxu; Jiang, Hao; Zhang, Jinzhe; Wei, Tong; Gu, Hongya; Qu, Li-Jia; Qin, Genji

2013-01-01

Leaf size and shape are mainly determined by coordinated cell division and differentiation in lamina. The CINCINNATA (CIN)-like TEOSINTE BRANCHED1/CYCLOIDEA/PCF (TCP) transcription factors are key regulators of leaf development. However, the mechanisms that control TCP activities during leaf development are largely unknown. We identified the TCP Interactor containing EAR motif protein1 (TIE1), a novel transcriptional repressor, as a major modulator of TCP activities during leaf development. Overexpression of TIE1 leads to hyponastic and serrated leaves, whereas disruption of TIE1 causes epinastic leaves. TIE1 is expressed in young leaves and encodes a transcriptional repressor containing a C-terminal EAR motif, which mediates interactions with the TOPLESS (TPL)/TOPLESS-RELATED (TPR) corepressors. In addition, TIE1 physically interacts with CIN-like TCPs. We propose that TIE1 regulates leaf size and morphology by inhibiting the activities of TCPs through recruiting the TPL/TPR corepressors to form a tertiary complex at early stages of leaf development. PMID:23444332

Cross-border ties as a source of risk and resilience: Do cross-border ties moderate the relationship between migration-related stress and psychological distress among Latino migrants in the United States?

PubMed Central

Torres, Jacqueline M.; Alcántara, Carmela; Rudolph, Kara E.; Viruell-Fuentes, Edna A.

2017-01-01

Few studies have examined the associations between health and the cross-border ties that migrants maintain with their family members in communities of origin. We draw on theory related to social ties, ethnic identity, and mental health to examine cross-border ties as potential moderators of the association between migration-related stress and psychological distress among Latino migrants. Using data from the National Latino and Asian American Survey, we find that remittance sending is associated with significantly lower levels of psychological distress for Cuban migrants, and difficulty visiting home is associated with significantly greater psychological distress for Puerto Rican migrants. There were significant associations between migration-related stressors and psychological distress, although these associations fell to non-significance after accounting for multiple testing. We found little evidence that cross-border ties either buffer or exacerbate the association between migration-related stressors and psychological distress. We consider the findings within the current political and historical context of cross-border ties and separation. PMID:27803264

[Medical equipment companies and their ties with technology development centers in Mexico].

PubMed

Hernández, B; Arredondo, A; Cruz, C; Sánchez, E; Damián, T

1993-10-01

The purpose of this study was to determine the characteristics of the companies that produce, distribute, and service medical equipment in Mexico and the factors related to whether or not they had established ties with research and technology development centers. The data analyzed came from a survey of such companies carried out in Mexico City and environs in 1989. The information was updated in 1991. Multivariate analyses were carried out in order to identify the characteristics of companies that had established ties or wished to do so and the areas of interest of those companies. Of 208 companies surveyed, only 23% had ties with research centers. The companies that had such ties or were interested in establishing them tended to invest in research and to have made plans for expansion. The establishment of ties appeared to be a two-way process, with positive consequences for the companies involved, the research centers, and the health sector. It was concluded that it would be advantageous to design programs to promote ties with companies having the characteristics mentioned.

Cross-border Ties as Sources of Risk and Resilience: Do Cross-border Ties Moderate the Relationship between Migration-related Stress and Psychological Distress for Latino Migrants in the United States?

PubMed

Torres, Jacqueline M; Alcántara, Carmela; Rudolph, Kara E; Viruell-Fuentes, Edna A

2016-12-01

Few studies have examined the associations between health and the cross-border ties that migrants maintain with their family members in communities of origin. We draw on theory related to social ties, ethnic identity, and mental health to examine cross-border ties as potential moderators of the association between migration-related stress and psychological distress among Latino migrants. Using data from the National Latino and Asian American Survey, we find that remittance sending is associated with significantly lower levels of psychological distress for Cuban migrants, and difficulty visiting home is associated with significantly greater psychological distress for Puerto Rican migrants. There were significant associations between migration-related stressors and psychological distress, although these associations fell to nonsignificance after accounting for multiple testing. We found little evidence that cross-border ties either buffer or exacerbate the association between migration-related stressors and psychological distress. We consider the findings within the current political and historical context of cross-border ties and separation. © American Sociological Association 2016.

Corruption and Coercion: University Autonomy versus State Control

ERIC Educational Resources Information Center

Osipian, Ararat L.

2008-01-01

A substantial body of literature considers excessive corruption an indicator of a weak state. However, in nondemocratic societies, corruption--whether informally approved, imposed, or regulated by public authorities--is often an indicator of a vertical power rather than an indicator of a weak state. This article explores the interrelations between…

School-Based Sexuality Education in Portugal: Strengths and Weaknesses

ERIC Educational Resources Information Center

Rocha, Ana Cristina; Leal, Cláudia; Duarte, Cidália

2016-01-01

Portugal, like many other countries, faces obstacles regarding school-based sexuality education. This paper explores Portuguese schools' approaches to implementing sexuality education at a local level, and provides a critical analysis of potential strengths and weaknesses. Documents related to sexuality education in a convenience sample of 89…

Performance evaluation of concrete railroad ties on the northeast corridor.

DOT National Transportation Integrated Search

2014-03-01

Simpson Gumpertz & Heger Inc. conducted an investigation into the factors that caused widespread failure in prestressed concrete : railroad ties on the Northeast Corridor. The problem was apparent in ties manufactured and installed circa 19941998....

The Missing Link: the Role of Floodplain Tie Channels in Connecting Off River Water Bodies to Lowland Rivers

NASA Astrophysics Data System (ADS)

Rowland, J. C.; Dietrich, W. E.; Day, G.

2005-05-01

Along lowland river systems across the globe the exchange of water, sediment, carbon, nutrients and biota between main stem rivers and off-river water bodies (ORWB) is facilitated by the presence of stable secondary channels referred to here as tie channels. Sixty five percent of the ORWB along the middle Fly River in Papua New Guinea connect to the river through such channels. A similar percentage of the 37 ORWB located between Baton Rouge and Memphis on the lower Mississippi River at one time were linked to the river by tie or batture (as they are locally known) channels. Levee construction and other alterations aimed at flood control or navigation on the Mississippi have left only a handful of lakes connected to the river, of these, most are heavily altered by dredging or other modifications. Tie channels were also once common along major tributaries to the Mississippi, such as the Red River. In the much less disturbed Alaskan environment, tie channels are still common, especially along Birch Creek and the Koyukuk and Black rivers. Our studies on the Mississippi River, in Alaska and in Papua New Guinea indicate that tie channels possess a common channel form that is stable and self-maintaining for hundreds to possibly a thousand years. Tie channels exhibit narrow width to depth ratios (~ 5.5) and consistently scale in cross-sectional dimensions to the size of the lake into which they flow. Variations in river and lake stage drive flow bi-directionally through tie channels. A local high or sill in the bed of tie channels controls the degree and duration of connection between the river and ORWB, with many lakes becoming isolated during periods of low stage. The life-span of a tie channel depends on the rate of sediment loading to the ORWB. Our research indicates that this rate directly corresponds to the sediment loading in the main stem river. Along the Fly River, for example, a 5 to 7 fold increase in the river sediment load has resulted increases of 6 to 17 times in tie channel progradation rates. In a few instances Fly River tie channels have become filled with sediment following the increase in sediment loading. The precise role of tie channels in the ecology of lowland river systems has yet to be quantified, but given their critical role in connecting rivers with floodplain habitats it is likely they provide an important source of refuge, breeding habitat, and biomass production for many aquatic organisms. As restoration efforts increasingly focus on the improving or reestablishing connectivity between lowland rivers and their floodplains, consideration should be given as to whether tie channels are an important missing component of such systems.

Lay information mediary behavior uncovered: exploring how nonprofessionals seek health information for themselves and others online.

PubMed

Abrahamson, Jennie A; Fisher, Karen E; Turner, Anne G; Durrance, Joan C; Turner, Tammara Combs

2008-10-01

This research studied motivations for, barriers to, and effects of online health information seeking and explored lay information mediary behavior (LIMB) characteristics in the consumer health information domain. Lay information mediaries (LIMs) seek information on behalf or because of others, without necessarily being asked to do so or engaging in follow up, and have represented more than 50% of health information seekers in prior studies. A web-based survey was posted on NC Health Info (NCHI) with 211 respondents, self-identified per the information need that brought them to NCHI as 20% LIMs (n = 43), 58% direct users (n = 122), and 22% health or information providers (n = 46). Follow-up telephone interviews were performed with 10% (n = 21). Interview analysis focused on lay participants (n = 15 LIMs and direct users combined). Interviewees were reclassified post-survey as 12 LIMs and 3 direct users when studied information behavior extended beyond NCHI search. Interview data were analyzed using grounded theory approach. Surveyed LIMs were 77% female (n = 33) and searched on behalf or because of family members (81%, n = 35) and people they felt "extremely close" to (77%, n = 33). LIMs reported various information seeking barriers "sometimes" to "often." LIMs searched mostly without prompting (51%, n = 22). Interview results triangulated survey findings regarding gender, tie strength, and prompting. LIMB may be related to gender and relationship tie strength and appears more internally than externally motivated. Further LIMB research is warranted.

Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET

PubMed Central

Peinado, Héctor; Alečković, Maša; Lavotshkin, Simon; Matei, Irina; Costa-Silva, Bruno; Moreno-Bueno, Gema; Hergueta-Redondo, Marta; Williams, Caitlin; García-Santos, Guillermo; Nitadori-Hoshino, Ayuko; Hoffman, Caitlin; Badal, Karen; Garcia, Benjamin A.; Callahan, Margaret K.; Yuan, Jianda; Martins, Vilma R.; Skog, Johan; Kaplan, Rosandra N.; Brady, Mary S.; Wolchok, Jedd D.; Chapman, Paul B.; Kang, Yibin; Bromberg, Jacqueline; Lyden, David

2013-01-01

Tumor-derived exosomes are emerging mediators of tumorigenesis with tissue-specific addresses and messages. We explored the function of melanoma-derived exosomes in the formation of primary tumor and metastases in mouse and human subjects. Exosomes from highly metastatic melanoma increased the metastatic behavior of primary tumors by permanently “educating” bone marrow (BM) progenitors via the MET receptor. Melanoma-derived exosomes also induced vascular leakiness at pre-metastatic sites, and reprogrammed BM progenitors towards a c-Kit+Tie2+Met+ pro-vasculogenic phenotype. Reducing Met expression in exosomes diminished the pro-metastatic behavior of BM cells. Importantly, MET expression was elevated in circulating CD45−C-KITlow/+TIE2+ BM progenitors from metastatic melanoma subjects. RAB1a, RAB5b, RAB7, and RAB27a were highly expressed in melanoma cells and Rab27a RNA interference decreased exosome production, preventing BM education, tumor growth and metastasis. Finally, we identified an exosome-specific “melanoma signature” with prognostic and therapeutic potential, comprised of TYRP2, VLA-4, HSP70, an HSP90 isoform and the MET oncoprotein. PMID:22635005

Maternal Differential Treatment in Later Life Families and Within-Family Variations in Adult Sibling Closeness

PubMed Central

Suitor, J. Jill; Nam, Sangbo

2015-01-01

Objectives. In this article, we explore within-family differences in the closeness of sibling ties in adulthood. Specifically, we consider the sibship as a network and investigate the ways in which perceptions of mothers’ differential treatment play a role in within-family variations in sibling closeness in midlife. Method. Data were analyzed from 2,067 adult sibling dyads nested within 216 later life families, collected as part of the Within-Family Differences Study-II. Results. Respondents reported the greatest closeness to siblings whom they perceived as favored by their mothers when they were not favored themselves, whereas respondents were less likely to choose siblings whom they perceived as disfavored by their mothers when they did not perceive themselves as disfavored. Discussion. Variability in the strength of sibling ties within families suggests that some individuals receive greater benefits from this relationship than do their brothers and sisters. These findings shed new light on such within-family variations in sibling closeness by identifying how specific patterns of maternal differential treatment draw offspring toward some siblings and away from others. PMID:25324293

Progress and Plans for the HIT--SI Experiment

NASA Astrophysics Data System (ADS)

Sieck, P. E.; Gu, P.; Hamp, W. T.; Izzo, V. A.; Jarboe, T. R.; Nelson, B. A.; O'Neill, R. G.; Redd, A. J.; Rogers, J. A.; Smith, R. J.

2002-11-01

The next step in the Helicity Injected Torus (HIT) program is HIT--SI, a ``bow tie'' spheromak to be formed and sustained by Steady Inductive Helicity Injection (SIHI). SIHI injects helicity at a nearly constant rate with no open field lines intersecting the boundary.(T. R. Jarboe, Fusion Technology 36) (1), p. 85, 1999 HIT--SI has been designed with a bow tie geometry to achieve stable high-β (>10%) spheromak equilibria.(U. Shumlak and T. R. Jarboe, Phys. Plasmas 7) (7), p. 2959, 2000 Injector dynamics depend greatly on reconnection rates in two locations: deep in the injector, and at the edge of the spheromak equilibrium. The first stage of HIT--SI operation concentrates on formation of a spheromak and sustainment for 1 ms, where the injector dynamics can be studied and the formation parameter space can be explored. Once these goals are met, the experiment will move into the second stage of operation, where the discharge duration will be extended and the device will inherit a suite of diagnostics from the existing HIT--II device.

Implementing hospital innovation in Taiwan: the perspectives of institutional theory and social capital.

PubMed

Yang, Chen-Wei

2015-01-01

The main purpose of this study is to develop an innovation model for hospital organisations. For this purpose, this study explores and examines the determinants, capabilities and performance in the hospital sector. First, this discusses three categories of determinants that affect hospitals' innovative capability studies: (1) knowledge stock; (2) social ties; and (3) institutional pressures. Then, this study examines the idea of innovative hospital capabilities, defined as the ability of the hospital organisation to innovate their knowledge. Finally, the hospital evaluation rating, which identifies performance in the hospital sector, was examined. This study empirically tested the theoretical model at the organisation level. The findings suggest that a hospital's innovative capabilities are influenced by its knowledge stock, social ties, institutional pressures and the impact of hospital performance. However, in attempts to keep hospitals aligned with their highly institutionalised environments, it may prove necessary for hospital administrators to pay more attention to both existing knowledge stock and the process of innovation if the institutions are to survive. Finally, implications for theory and practitioners complete this study. Copyright © 2014 John Wiley & Sons, Ltd.

Associations between social identity diversity, compatibility, and recovery capital amongst young people in substance use treatment.

PubMed

Mawson, E; Best, D; Lubman, D I

2016-12-01

This study explored associations between group memberships and recovery capital amongst 20 young adults aged 18 to 21 years in residential alcohol and drug treatment. Participants completed an interviewer administered research interview based on measures of recovery capital and a social networks assessment mapping group memberships, group substance use, and relationships between groups. Higher personal and social recovery capital was associated with lower diversity of group memberships, a higher number of positive links between groups, and greater compatibility of lower substance-using groups with other groups in the network. Higher compatibility of heavier-using groups was also associated with having a higher number of negative, antagonistic ties between groups. These findings indicate that it is higher compatibility of a lower substance-using social identity and lower-using group memberships that contributes to recovery capital. Further, positive ties between groups and lower diversity of group memberships appear to be key aspects in how multiple social identities that are held by young adults relate to personal and social recovery capital.

Breaking Up is Hard to Do, Unless Everyone Else is Doing it Too: Social Network Effects on Divorce in a Longitudinal Sample

PubMed Central

McDermott, Rose; Fowler, James; Christakis, Nicholas

2014-01-01

Divorce represents the dissolution of a social tie, but it is also possible that attitudes about divorce flow across social ties. To explore how social networks influence divorce and vice versa, we exploit a longitudinal data set from the long-running Framingham Heart Study. The results suggest that divorce can spread between friends. Clusters of divorces extend to two degrees of separation in the network. Popular people are less likely to get divorced, divorcees have denser social networks, and they are much more likely to remarry other divorcees. Interestingly, the presence of children does not influence the likelihood of divorce, but each child reduces the susceptibility to being influenced by peers who get divorced. Overall, the results suggest that attending to the health of one’s friends’ marriages may serve to support and enhance the durability of one’s own relationship, and that, from a policy perspective, divorce should be understood as a collective phenomenon that extends beyond those directly affected. PMID:24748689

How Can Intergroup Interaction Be Bad If Intergroup Contact Is Good? Exploring and Reconciling an Apparent Paradox in the Science of Intergroup Relations

PubMed Central

Page-Gould, Elizabeth

2015-01-01

The outcomes of social interactions among members of different groups (e.g., racial groups, political groups, sexual orientation groups) have long been of interest to psychologists. Two related literatures on the topic have emerged—the intergroup interaction literature and the intergroup contact literature—in which divergent conclusions have been reported. Intergroup interaction is typically found to have negative effects tied to intergroup bias, producing heightened stress, intergroup anxiety, or outgroup avoidance, whereas intergroup contact is typically found to have positive effects tied to intergroup bias, predicting lower intergroup anxiety and lower prejudice. We examine these paradoxical findings, proposing that researchers contributing to the two literatures are examining different levels of the same phenomenon and that methodological differences can account for the divide between the literatures. Further, we introduce a mathematical model by which the findings of the two literatures can be reconciled. We believe that adopting this model will streamline thinking in the field and will generate integrative new research in which investigators examine how a person’s experiences with diversity unfold. PMID:25987510

Cryogenic support system

DOEpatents

Nicol, Thomas H.; Niemann, Ralph C.; Gonczy, John D.

1988-01-01

A support system is disclosed for restraining large masses at very low or cryogenic temperatures. The support system employs a tie bar that is pivotally connected at opposite ends to an anchoring support member and a sliding support member. The tie bar extends substantially parallel to the longitudinal axis of the cold mass assembly, and comprises a rod that lengthens when cooled and a pair of end attachments that contract when cooled. The rod and end attachments are sized so that when the tie bar is cooled to cryogenic temperature, the net change in tie bar length is approximately zero. Longitudinal force directed against the cold mass assembly is distributed by the tie bar between the anchoring support member and the sliding support member.

Influence of emergency physician's tying technique on knot security.

PubMed

Batra, E K; Franz, D A; Towler, M A; Rodeheaver, G T; Thacker, J G; Zimmer, C A; Edlich, R F

1992-01-01

The purpose of this study was to determine the influence of emergency physician's tying technique on knot security using 2-0 and 4-0 monofilament and multifilament nylon sutures. Using an Instron Tensile Tester and a portable tensiometer, knot security was achieved with these sutures using four-throw square knots (1 = 1 = 1 = 1). After didactic and psychomotor skill training, medical students were taught to construct the four-throw square knot using either a two-hand tie or an instrument tie. Using the portable tensiometer, their knot tying techniques were judged to be superior to those used by emergency physicians. The emergency physician's faulty technique can easily be corrected by didactic information and psychomotor skill training.

Concept Based Tie-breaking and Maximal Marginal Relevance Retrieval in Microblog Retrieval

DTIC Science & Technology

2014-11-01

the same score, another singal will be used to rank these documents to break the ties , but the relative orders of other documents against these...documents remain the same. The tie- breaking step above is repeatedly applied to further break ties until all candidate signals are applied and the ranking...searched it on the Yahoo! search engine, which returned some query sug- gestions for the query. The original queries as well as their query suggestions

ANG-1 TIE-2 and BMPR Signalling Defects Are Not Seen in the Nitrofen Model of Pulmonary Hypertension and Congenital Diaphragmatic Hernia

PubMed Central

Corbett, Harriet Jane; Connell, Marilyn Gwen; Fernig, David Garth

2012-01-01

Background Pulmonary hypertension (PH) is a lethal disease that is associated with characteristic histological abnormalities of the lung vasculature and defects of angiopoetin-1 (ANG-1), TIE-2 and bone morphogenetic protein receptor (BMPR)-related signalling. We hypothesized that if these signalling defects cause PH generically, they will be readily identifiable perinatally in congenital diaphragmatic hernia (CDH), where the typical pulmonary vascular changes are present before birth and are accompanied by PH after birth. Methods CDH (predominantly left-sided, LCDH) was created in Sprague-Dawley rat pups by e9.5 maternal nitrofen administration. Left lungs from normal and LCDH pups were compared at fetal and postnatal time points for ANG-1, TIE-2, phosphorylated-TIE-2, phosphorylated-SMAD1/5/8 and phosphorylated-ERK1/2 by immunoprecipitation and Western blotting of lung protein extracts and by immunohistochemistry on lung sections. Results In normal lung, pulmonary ANG-1 protein levels fall between fetal and postnatal life, while TIE-2 levels increase. Over the corresponding time period, LCDH lung retained normal expression of ANG-1, TIE-2, phosphorylated-TIE-2 and, downstream of BMPR, phosphorylated-SMAD1/5/8 and phosphorylated-p44/42. Conclusion In PH and CDH defects of ANG-1/TIE-2/BMPR-related signalling are not essential for the lethal vasculopathy. PMID:22539968

Impaired angiopoietin/Tie2 signaling compromises Schlemm’s canal integrity and induces glaucoma

PubMed Central

Kim, Jaeryung; Park, Dae-Young; Park, Do Young; Kim, Dongkyu; Lee, Choong-kun; Song, Sukhyun; Chung, Tae-Young; Lim, Dong Hui; Hong, Young-Kwon; Augustin, Hellmut G.

2017-01-01

Primary open-angle glaucoma (POAG) is often caused by elevated intraocular pressure (IOP), which arises due to increased resistance to aqueous humor outflow (AHO). Aqueous humor flows through Schlemm’s canal (SC), a lymphatic-like vessel encircling the cornea, and via intercellular spaces of ciliary muscle cells. However, the mechanisms underlying increased AHO resistance are poorly understood. Here, we demonstrate that signaling between angiopoietin (Angpt) and the Angpt receptor Tie2, which is critical for SC formation, is also indispensable for maintaining SC integrity during adulthood. Deletion of Angpt1/Angpt2 or Tie2 in adult mice severely impaired SC integrity and transcytosis, leading to elevated IOP, retinal neuron damage, and impairment of retinal ganglion cell function, all hallmarks of POAG in humans. We found that SC integrity is maintained by interconnected and coordinated functions of Angpt-Tie2 signaling, AHO, and Prox1 activity. These functions diminish in the SC during aging, leading to impaired integrity and transcytosis. Intriguingly, Tie2 reactivation using a Tie2 agonistic antibody rescued the POAG phenotype in Angpt1/Angpt2-deficient mice and rejuvenated the SC in aged mice. These results indicate that the Angpt-Tie2 system is essential for SC integrity. The impairment of this system underlies POAG-associated pathogenesis, supporting the possibility that Tie2 agonists could be a therapeutic option for glaucoma. PMID:28920924

Financial ties of principal investigators and randomized controlled trial outcomes: cross sectional study.

PubMed

Ahn, Rosa; Woodbridge, Alexandra; Abraham, Ann; Saba, Susan; Korenstein, Deborah; Madden, Erin; Boscardin, W John; Keyhani, Salomeh

2017-01-17

 To examine the association between the presence of individual principal investigators' financial ties to the manufacturer of the study drug and the trial's outcomes after accounting for source of research funding.  Cross sectional study of randomized controlled trials (RCTs).  Studies published in "core clinical" journals, as identified by Medline, between 1 January 2013 and 31 December 2013.  Random sample of RCTs focused on drug efficacy.  Association between financial ties of principal investigators and study outcome.  A total of 190 papers describing 195 studies met inclusion criteria. Financial ties between principal investigators and the pharmaceutical industry were present in 132 (67.7%) studies. Of 397 principal investigators, 231 (58%) had financial ties and 166 (42%) did not. Of all principal investigators, 156 (39%) reported advisor/consultancy payments, 81 (20%) reported speakers' fees, 81 (20%) reported unspecified financial ties, 52 (13%) reported honorariums, 52 (13%) reported employee relationships, 52 (13%) reported travel fees, 41 (10%) reported stock ownership, and 20 (5%) reported having a patent related to the study drug. The prevalence of financial ties of principal investigators was 76% (103/136) among positive studies and 49% (29/59) among negative studies. In unadjusted analyses, the presence of a financial tie was associated with a positive study outcome (odds ratio 3.23, 95% confidence interval 1.7 to 6.1). In the primary multivariate analysis, a financial tie was significantly associated with positive RCT outcome after adjustment for the study funding source (odds ratio 3.57 (1.7 to 7.7). The secondary analysis controlled for additional RCT characteristics such as study phase, sample size, country of first authors, specialty, trial registration, study design, type of analysis, comparator, and outcome measure. These characteristics did not appreciably affect the relation between financial ties and study outcomes (odds ratio 3.37, 1.4 to 7.9).  Financial ties of principal investigators were independently associated with positive clinical trial results. These findings may be suggestive of bias in the evidence base. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

Financial ties of principal investigators and randomized controlled trial outcomes: cross sectional study

PubMed Central

Ahn, Rosa; Woodbridge, Alexandra; Abraham, Ann; Saba, Susan; Korenstein, Deborah; Madden, Erin; Boscardin, W John

2017-01-01

Objective To examine the association between the presence of individual principal investigators’ financial ties to the manufacturer of the study drug and the trial’s outcomes after accounting for source of research funding. Design Cross sectional study of randomized controlled trials (RCTs). Setting Studies published in “core clinical” journals, as identified by Medline, between 1 January 2013 and 31 December 2013. Participants Random sample of RCTs focused on drug efficacy. Main outcome measure Association between financial ties of principal investigators and study outcome. Results A total of 190 papers describing 195 studies met inclusion criteria. Financial ties between principal investigators and the pharmaceutical industry were present in 132 (67.7%) studies. Of 397 principal investigators, 231 (58%) had financial ties and 166 (42%) did not. Of all principal investigators, 156 (39%) reported advisor/consultancy payments, 81 (20%) reported speakers’ fees, 81 (20%) reported unspecified financial ties, 52 (13%) reported honorariums, 52 (13%) reported employee relationships, 52 (13%) reported travel fees, 41 (10%) reported stock ownership, and 20 (5%) reported having a patent related to the study drug. The prevalence of financial ties of principal investigators was 76% (103/136) among positive studies and 49% (29/59) among negative studies. In unadjusted analyses, the presence of a financial tie was associated with a positive study outcome (odds ratio 3.23, 95% confidence interval 1.7 to 6.1). In the primary multivariate analysis, a financial tie was significantly associated with positive RCT outcome after adjustment for the study funding source (odds ratio 3.57 (1.7 to 7.7). The secondary analysis controlled for additional RCT characteristics such as study phase, sample size, country of first authors, specialty, trial registration, study design, type of analysis, comparator, and outcome measure. These characteristics did not appreciably affect the relation between financial ties and study outcomes (odds ratio 3.37, 1.4 to 7.9). Conclusions Financial ties of principal investigators were independently associated with positive clinical trial results. These findings may be suggestive of bias in the evidence base. PMID:28096109

Freeze-thaw performance testing of whole concrete railroad ties.

DOT National Transportation Integrated Search

2013-10-01

Freezing and thawing durability tests of prestressed concrete ties are normally performed according to ASTM C666 specifications. Small specimens are cut from the shoulders of concrete ties and tested through 300 cycles of freezing and thawing. Saw-cu...

Economics of Concrete and Wood Tie Track Structures

DOT National Transportation Integrated Search

1978-08-01

This report presents results from an evaluation of the economic benefits of concrete- versus wood-tie track. The analysis includes the life-cycle capital, maintenance, and renewal costs for concrete- and wood-tie track for four specific test cases an...

Aspects of some dualities in string theory

NASA Astrophysics Data System (ADS)

Kim, Bom Soo

AdS/CFT correspondence in string theory has changed landscape of the theoretical physics. Through this celebrated duality between gravity theory and field theory, one can investigate analytically strongly coupled gauge theories such as Quantum Chromodynamics (QCD) in terms of weakly coupled string theory such as supergravity theory and vice versa. In the first part of this thesis we used this duality to construct a new type of nonlocal field theory, called Puff Field Theory, in terms of D3 branes in type IIB string theory with a geometric twist. In addition to the strong-weak duality of AdS/CFT, there also exists a weak-weak duality, called Twistor String Theory. Twistor technique is successfully used to calculate the SYM scattering amplitude in an elegant fashion. Yet, the progress in the string theory side was hindered by a non-unitary conformal gravity. We extend the Twistor string theory by introducing mass terms, in the second part of the thesis. A chiral mass term is identified as a vacuum expectation value of a conformal supergravity field and is tied with the breaking of the conformal symmetry of gravity. As a prime candidate for a quantum theory of gravity, string theory revealed many promising successes such as counting the number of microstates in supersymmetric Black Holes thermodynamics and resolution of timelike and null singularities, to name a few. Yet, the fundamental string and M-theroy formulations are not yet available. Various string theories without gravity, such as Non-Commutative Open String (NCOS) and Open Membrane (OM) theories, are very nice playground to investigate the fundamental structure of string and M-theory without the complication of gravity. In the last part of the thesis, simpler Non-Relativistic String Theories are constructed and investigated. One important motivation for those theories is related to the connection between Non-Relativistic String Theories and Non-critical String Theories through the bosonization of betagamma CFT.

Enceladus Plumes: Causes of Decadal Variability

NASA Astrophysics Data System (ADS)

Ingersoll, Andrew P.; Ewald, Shawn P.

2016-10-01

The Enceladus plumes have decreased over the decade that Cassini has been observing them. This long-term variation is superposed on the much shorter-term variation tied to the position of Enceladus in its orbit around Saturn. The observations are ISS and VIMS images, which reveal the particles in the plumes but not the gas. The decadal variability largely consists of a 2-fold decline in the mass of plume material, but there is a hint of a recent turnaround. Here we offer three hypotheses, each with its strengths and weaknesses, to explain the long-term variability. The first is seasonal change, from summer to fall in the southern hemisphere. The loss of sunlight could increase the build-up of ice around the tiger stripes. The weakness is that the sunlight is likely to have a small effect, e.g., decreasing the sublimation rate of the ice by only ~1 cm/year. The second hypothesis is a statistical fluctuation in the number of active plumes, which tend to turn themselves off due to build-up of ice at the throat of the vent. The weakness is that the plumes are likely to fluctuate independently, and if there are ~100 plumes, their sum will only fluctuate by 10%. The third hypothesis is that the variation is part of a well-known decadal cycle of orbital eccentricity, which varies by ±2.5% around a mean of 0.0047. The peak eccentricity occurred in 2009-2010, and the minimum occurred in 2015. Since eccentricity controls the short-term orbital cycle variations, it could also control the longer-term decadal variations. The weakness is that the eccentricity variation is small, from 0.0046 to 0.0048. It is not certain that such a small variation could cause a 2-fold variation in the strength of the plumes. An independent study, still in its infancy, is the possibility that liquid water reaches the surface during part of the orbital cycle.

Global TIE: Developing a Virtual Network of Robotic Observatories for K-12 Education

NASA Astrophysics Data System (ADS)

Mayo, L. A.; Clark, G.

2001-11-01

Astronomy in grades K-12 is traditionally taught (if at all) using textbooks and a few simple hands-on activities. In addition, most students, by High School graduation, will never have even looked through the eyepiece of a telescope. The possibility now exists to establish a network of research grade telescopes, no longer useful to the professional astronomical community, that can be made accessible to schools all across the country through existing IT technologies and applications. These telescopes could provide unparalleled research and educational opportunities for a broad spectrum of K-12 and college students and turns underutilized observatory facilities into valuable, state-of-the-art teaching centers. The NASA-sponsored Telescopes In Education (TIE, http://tie.jpl.nasa.gov) project has been wildly successful in engaging the K-12 education community in real-time, hands-on, interactive astronomy activities. Hundreds of schools in the US, Australia, Canada, England, and Japan have participated in the TIE program, remotely controlling the 24-inch telescope at the Mount Wilson Observatory from their classrooms. In recent years, several (approximately 20 to date) other telescopes have been, or are in the process of being, outfitted for remote use as TIE affiliates. Global TIE integrates these telescopes seamlessly into one virtual observatory and provides the services required to operate this facility, including a scheduling service, tools for data manipulation, an online proposal review environment, an online "Virtual TIE Student Ap J" for publication of results, and access to related educational materials provided by the TIE community. Global TIE provides unparalleled research and educational opportunities for a broad spectrum of K-12 and college students and turns essentially unused observatory facilities into valuable, state-of-the-art teaching centers. This presentation describes the Global TIE Observatory data and organizational systems and details the technology, partnerships, operational capabilities, science applications, and learning opportunities that this powerful virtual observatory network will provide.

Selection based on the size of the black tie of the great tit may be reversed in urban habitats.

PubMed

Senar, Juan Carlos; Conroy, Michael J; Quesada, Javier; Mateos-Gonzalez, Fernando

2014-07-01

A standard approach to model how selection shapes phenotypic traits is the analysis of capture-recapture data relating trait variation to survival. Divergent selection, however, has never been analyzed by the capture-recapture approach. Most reported examples of differences between urban and nonurban animals reflect behavioral plasticity rather than divergent selection. The aim of this paper was to use a capture-recapture approach to test the hypothesis that divergent selection can also drive local adaptation in urban habitats. We focused on the size of the black breast stripe (i.e., tie width) of the great tit (Parus major), a sexual ornament used in mate choice. Urban great tits display smaller tie sizes than forest birds. Because tie size is mostly genetically determined, it could potentially respond to selection. We analyzed capture/recapture data of male great tits in Barcelona city (N = 171) and in a nearby (7 km) forest (N = 324) from 1992 to 2008 using MARK. When modelling recapture rate, we found it to be strongly influenced by tie width, so that both for urban and forest habitats, birds with smaller ties were more trap-shy and more cautious than their larger tied counterparts. When modelling survival, we found that survival prospects in forest great tits increased the larger their tie width (i.e., directional positive selection), but the reverse was found for urban birds, with individuals displaying smaller ties showing higher survival (i.e., directional negative selection). As melanin-based tie size seems to be related to personality, and both are heritable, results may be explained by cautious personalities being favored in urban environments. More importantly, our results show that divergent selection can be an important mechanism in local adaptation to urban habitats and that capture-recapture is a powerful tool to test it.

Peer Influence, Peer Selection and Adolescent Alcohol Use: a Simulation Study Using a Dynamic Network Model of Friendship Ties and Alcohol Use.

PubMed

Wang, Cheng; Hipp, John R; Butts, Carter T; Jose, Rupa; Lakon, Cynthia M

2017-05-01

While studies suggest that peer influence can in some cases encourage adolescent substance use, recent work demonstrates that peer influence may be on average protective for cigarette smoking, raising questions about whether this effect occurs for other substance use behaviors. Herein, we focus on adolescent drinking, which may follow different social dynamics than smoking. We use a data-calibrated Stochastic Actor-Based (SAB) Model of adolescent friendship tie choice and drinking behavior to explore the impact of manipulating the size of peer influence and selection effects on drinking in two school-based networks. We first fit a SAB Model to data on friendship tie choice and adolescent drinking behavior within two large schools (n = 2178 and n = 976) over three time points using data from the National Longitudinal Study of Adolescent to Adult Health. We then alter the size of the peer influence and selection parameters with all other effects fixed at their estimated values and simulate the social systems forward 1000 times under varying conditions. Whereas peer selection appears to contribute to drinking behavior similarity among adolescents, there is no evidence that it leads to higher levels of drinking at the school level. A stronger peer influence effect lowers the overall level of drinking in both schools. There are many similarities in the patterning of findings between this study of drinking and previous work on smoking, suggesting that peer influence and selection may function similarly with respect to these substances.

Financial and Emotional Support in Close Personal Ties among Central Asian Migrant Women in Russia.

PubMed

Kornienko, Olga; Agadjanian, Victor; Menjívar, Cecilia; Zotova, Natalia

2018-05-01

This study advances research on the role of personal networks as sources of financial and emotional support in immigrants' close personal ties beyond the immediate family. Because resource scarcity experienced by members of immigrant communities is likely to disrupt normatively expected reciprocal support, we explored multi-level predictors of exchange processes with personal network members that involve (1) only receiving support, (2) only providing support, and (3) reciprocal support exchanges. We focus on an understudied case of Central Asian migrant women in the Russian Federation using a sample of 607 women from three ethnic groups-Kyrgyz, Tajik, Uzbek-who were surveyed in two large Russian cities-Nizhny Novgorod and Kazan. The survey collected information on respondents' demographic, socioeconomic, and migration-related characteristics, as well as characteristics of up to five individuals with whom they had a close relationship. Multi-level multinomial regression analyses were used to account for the nested nature of the data. Our results revealed that closer social relationships (siblings and friends) and greater levels of resources (income and regularized legal status) at both ego and alter levels were positively related to providing, receiving, and reciprocally exchanging financial and emotional support. Egos were more likely to provide financial assistance to transnational alters, whereas they were more likely to engage in mutual exchanges of emotional support with their network members from other countries. Personal network size and density showed no relationship with support exchanges. These findings provide a nuanced picture of close personal ties as conduits for financial and emotional support in migrant communities in a major, yet understudied, migrant-receiving context.

Challenging Ties between State and Tobacco Industry: Advocacy Lessons from India

PubMed Central

Bhojani, Upendra; Venkataraman, Vidya; Manganawar, Bheemaray

2013-01-01

Background: Globally, tobacco use is a major public health concern given its huge morbidity and mortality burden that is inequitably high in low- and middle-income countries. The World Health Organization has suggested banning the advertisement, promotion and sponsorship of tobacco. However, governments in some countries, including India, are either directly engaged in tobacco industry operations or have a mandate to promote tobacco industry development. This paper analyses a short-term advocacy campaign that challenged the state-tobacco industry ties to draw lessons for effective public health advocacy. Method: This paper uses a case study method to analyze advocacy efforts in India to thwart the state-tobacco industry partnership: the Indian government’s sponsorship and support to a global tobacco industry event. The paper explores multiple strategies employed in the five-month advocacy campaign (May to October 2010) to challenge this state-industry tie. In doing so, we describe the challenges faced and the lessons learnt for effective advocacy. Results: Government withdrew participation and financial sponsorship from the tobacco industry event. Use of multiple strategies including engaging all concerned government agencies from the beginning, strategic use of media, presence and mobilization of civil society, and use of legal tools to gain information and judicial action, were complementary in bringing desired outcomes. Conclusion: Use of multiple and complementary advocacy strategies could lead to positive outcomes in a short-time campaign. The Framework Convention on Tobacco Control could form an important advocacy tool, especially in countries that have ratified it, to advocate for improvements in national tobacco control regulations. PMID:24688958

Bone marrow endothelial progenitors augment atherosclerotic plaque regression in a mouse model of plasma lipid lowering

PubMed Central

Yao, Longbiao; Heuser-Baker, Janet; Herlea-Pana, Oana; Iida, Ryuji; Wang, Qilong; Zou, Ming-Hui; Barlic-Dicen, Jana

2012-01-01

The major event initiating atherosclerosis is hypercholesterolemia-induced disruption of vascular endothelium integrity. In settings of endothelial damage, endothelial progenitor cells (EPCs) are mobilized from bone marrow into circulation and home to sites of vascular injury where they aid endothelial regeneration. Given the beneficial effects of EPCs in vascular repair, we hypothesized that these cells play a pivotal role in atherosclerosis regression. We tested our hypothesis in the atherosclerosis-prone mouse model in which hypercholesterolemia, one of the main factors affecting EPC homeostasis, is reversible (Reversa mice). In these mice normalization of plasma lipids decreased atherosclerotic burden; however, plaque regression was incomplete. To explore whether endothelial progenitors contribute to atherosclerosis regression, bone marrow EPCs from a transgenic strain expressing green fluorescent protein under the control of endothelial cell-specific Tie2 promoter (Tie2-GFP+) were isolated. These cells were then adoptively transferred into atheroregressing Reversa recipients where they augmented plaque regression induced by reversal of hypercholesterolemia. Advanced plaque regression correlated with engraftment of Tie2-GFP+ EPCs into endothelium and resulted in an increase in atheroprotective nitric oxide and improved vascular relaxation. Similarly augmented plaque regression was also detected in regressing Reversa mice treated with the stem cell mobilizer AMD3100 which also mobilizes EPCs to peripheral blood. We conclude that correction of hypercholesterolemia in Reversa mice leads to partial plaque regression that can be augmented by AMD3100 treatment or by adoptive transfer of EPCs. This suggests that direct cell therapy or indirect progenitor cell mobilization therapy may be used in combination with statins to treat atherosclerosis. PMID:23081735

Resonant tunneling of 1-dimensional electrons across an array of 3-dimensionally confined potential wells

NASA Astrophysics Data System (ADS)

Allee, D. R.; Chou, S. Y.; Harris, J. S.; Pease, R. F. W.

A lateral resonant tunneling field effect transistor has been fabricated with a gate electrode in the form of a railway such that the two rails form a lateral double barrier potential at the GaAs/AlGaAs interface. The ties confine the electrons in the third dimension forming an array of potential boxes or three dimensionally confined potential wells. The width of the ties and rails is 50nm; the spacings between the ties and between the two rails are 230nm and 150nm respectively. The ties are 750nm long and extend beyond the the two rails forming one dimensional wires on either side. Conductance oscillations are observed in the drain current at 4.2K as the gate voltage is scanned. Comparison with devices with a solid gate, and with a monorail gate with ties fabricated on the same wafer suggest that these conductance oscillations are electron resonant tunneling from one dimensional wires through the quasi-bound states of the three dimensionally confined potential wells. Comparison with a device with a two rail gate without ties (previously published) indicates that additional confinement due to the ties enhances the strength of the conductance oscillations.

Linkage of genomic biomarkers to whole organism endpoints in a Toxicity Identification Evaluation (TIE).

EPA Science Inventory

Aquatic organisms are exposed to many toxic chemicals and interpreting the cause and effect relationships between occurrence and impairment is difficult. Toxicity Identification Evaluation (TIE) provides a systematic approach for identifying responsible toxicants. TIE relies on ...

Measurement Program for Evaluation of Concrete Ties and Fastenings in Transit Track

DOT National Transportation Integrated Search

1979-03-01

This report outlines a measurement program to obtain data on the performance of standard tie designs and associated fastening systems under field service conditions. In addition, the program identifies limited data to be obtained from a wood tie trac...

Performance and Characterization of Shear Ties for Use in Insulated Precast Concrete Sandwich Wall Panels

DTIC Science & Technology

2010-11-01

stainless 14 steel, galvanized carbon steel, carbon- fiber -reinforced polymer (CFRP), glass- fiber -reinforced polymer 15 (GFRP), and basalt - fiber ...CFRP Grid, (E) Universal Building Products GFRP Teplo Tie, and (F) Universal Building Products 6 Basalt FRP RockBar. Traditional steel connections...1.6 E Universal Building Products TeploTie GFRP Tie 10 mm dia. x 150 mm F RockBar Basalt FRP Bar 7 in. x 5/16 in. G TSA Manufacturing C-Clip

Characterization and Fate of Gun and Rocket Propellant Residues on Testing and Training Ranges

DTIC Science & Technology

2011-08-01

propellant sticks, is tied in three places with polyester and cotton thread ties. The bundle is then wrapped in lead foil (a de-coppering agent...sticks and the tying of the bundle in five places, again using polyester and cotton thread ties. The combustible case is manufactured mainly from...and brought back to DRDC to be weighed and extracted to measure the remaining 2,4-DNT. Most of what was collected was the remains of the cotton

Empirical Evaluation of a Model of Team Collaboration Using Selected Transcripts from September 11, 2001

DTIC Science & Technology

2009-06-01

close coordination between the FAA and NORAD is required in order to maintain safety of the U.S. airspace. In order to interpret how the FAA and...386 Sergeant Bianchi: Hi, Sergeant Lucas calling from Lotus . MISC MISC MISC 387 Sergeant Bianchi: Yeah. MISC MISC MISC 388 Sergeant Lucas...TIE These guys have been sitting here and messing with this stuff. TIE US TIE You need some kind of food . TIE MISC MISC Sir

Cross-border Ties and Arab American Mental Health

PubMed Central

Samari, Goleen

2016-01-01

Due to increasing discrimination and marginalization, Arab Americans are at a greater risk for mental health disorders. Social networks that include ties to the country of origin could help promote mental well-being in the face of discrimination. The role of countries of origin in immigrant mental health receives little attention compared to adjustment in destination contexts. This study addresses this gap by analyzing the relationship between nativity, cross-border ties, and psychological distress and happiness for Arab Americans living in the greater Detroit Metropolitan Area (N=896). I expect that first generation Arab Americans will have more psychological distress compared to one and half, second, and third generations, and Arab Americans with more cross-border ties will have less psychological distress and more happiness. Data come from the 2003 Detroit Arab American Study, which includes measures of nativity, cross-border ties – attitudes, social ties, media consumption, and community organizations, and the Kessler-10 scale of psychological distress and self-reported happiness. Ordered logistic regression analyses suggest that psychological distress and happiness do not vary much by nativity alone. However, cross-border ties have both adverse and protective effects on psychological distress and happiness. For all generations of Arab Americans, cross-border attitudes and social ties are associated with greater odds of psychological distress and for first generation Arab Americans, media consumption is associated with greater odds of unhappiness. In contrast, for all generations, involvement in cross-border community organizations is associated with less psychological distress and for the third generation, positive cross-border attitudes are associated with higher odds of happiness. These findings show the complex relationship between cross-border ties and psychological distress and happiness for different generations of Arab Americans. PMID:26999416

Cross-border ties and Arab American mental health.

PubMed

Samari, Goleen

2016-04-01

Due to increasing discrimination and marginalization, Arab Americans are at a greater risk for mental health disorders. Social networks that include ties to the country of origin could help promote mental well-being in the face of discrimination. The role of countries of origin in immigrant mental health receives little attention compared to adjustment in destination contexts. This study addresses this gap by analyzing the relationship between nativity, cross-border ties, and psychological distress and happiness for Arab Americans living in the greater Detroit Metropolitan Area (N = 896). I expect that first generation Arab Americans will have more psychological distress compared to one and half, second, and third generations, and Arab Americans with more cross-border ties will have less psychological distress and more happiness. Data come from the 2003 Detroit Arab American Study, which includes measures of nativity, cross-border ties--attitudes, social ties, media consumption, and community organizations, and the Kessler-10 scale of psychological distress and self-reported happiness. Ordered logistic regression analyses suggest that psychological distress and happiness do not vary much by nativity alone. However, cross-border ties have both adverse and protective effects on psychological distress and happiness. For all generations of Arab Americans, cross-border attitudes and social ties are associated with greater odds of psychological distress and for first generation Arab Americans, media consumption is associated with greater odds of unhappiness. In contrast, for all generations, involvement in cross-border community organizations is associated with less psychological distress and for the third generation, positive cross-border attitudes are associated with higher odds of happiness. These findings show the complex relationship between cross-border ties and psychological distress and happiness for different generations of Arab Americans. Copyright © 2016 Elsevier Ltd. All rights reserved.

Cryogenic support system

DOEpatents

Nicol, T.H.; Niemann, R.C.; Gonczy, J.D.

1988-11-01

A support system is disclosed for restraining large masses at very low or cryogenic temperatures. The support system employs a tie bar that is pivotally connected at opposite ends to an anchoring support member and a sliding support member. The tie bar extends substantially parallel to the longitudinal axis of the cold mass assembly, and comprises a rod that lengthens when cooled and a pair of end attachments that contract when cooled. The rod and end attachments are sized so that when the tie bar is cooled to cryogenic temperature, the net change in tie bar length is approximately zero. Longitudinal force directed against the cold mass assembly is distributed by the tie bar between the anchoring support member and the sliding support member. 7 figs.

Impact of ionization equilibrium on electrokinetic flow of weak electrolytes in nanochannels

NASA Astrophysics Data System (ADS)

Ji, Ziwei; Huang, Zhuo; Chen, Bowei; He, Yuhui; Tsutsui, Makusu; Miao, Xiangshui

2018-07-01

Weak electrolyte transport in nanochannels or nanopores has been actively explored in recent experiments. In this paper, we establish a new electrokinetic model where the ionization balance effect of weak electrolytes is outlined, and performed numerical calculations for H3PO4 concentration-biased nanochannel systems. By considering the roles of local chemical equilibrium in phosphorous acid ionization, the simulation results show quantitative agreement with experimental observations. Based on the model, we predict that enhanced energy harvesting capacity could be accomplished by utilizing weak electrolytes compared to the conventional strong electrolyte approaches in a concentration gradient-based power-generating system.

Effect of Wheel/Rail Loads on Concrete Tie Stresses and Rail Rollover.

DOT National Transportation Integrated Search

2011-09-21

As a result of vertical and lateral wheel/rail forces, high contact stresses can develop at the interface between the rail base and tie. Under certain conditions, these stresses can exceed the strength of the concrete tie and result in deterioration ...

Unmatter Plasma revisited

NASA Astrophysics Data System (ADS)

Smarandache, Florentin

2017-10-01

Unmmatter Plasma is a novel form of plasma, exclusively made of matter and its antimatter counterpart. The electron-positron beam plasma was generated in the laboratory in the beginning of 2015. This experimental fact shows that unmatter, a new form of matter that is formed by matter and antimatter bind together (mathematically predicted since 2004) really exists. That is the electron-positron plasma experiment of 2015 is the experimentum crucis verifying the mathematically predicted unmatter. Unmatter is formed by combinations of matter and antimatter that bind together, or by long-range mixture of matter and antimatter forming a weakly-coupled phase. Binding and bound state means that the interaction is sufficiently strong to tie together the particles of a system, therefore hindering them from becoming free. For example, a usual liquid is a bound state of molecules, while a gas is an un-bounded where the molecules can move freely in successive collisions.

Point matching: A new electronic method for homogenizing the phase characteristics of giant magnetoimpedance sensors

DOE Office of Scientific and Technical Information (OSTI.GOV)

Silva, E. Costa, E-mail: edusilva@ele.puc-rio.br; Gusmão, L. A. P.; Barbosa, C. R. Hall

2014-08-15

Recently, our research group at PUC-Rio discovered that magnetic transducers based on the impedance phase characteristics of GMI sensors have the potential to multiply by one hundred the sensitivity values when compared to magnitude-based GMI transducers. Those GMI sensors can be employed in the measurement of ultra-weak magnetic fields, which intensities are even lower than the environmental magnetic noise. A traditional solution for cancelling the electromagnetic noise and interference makes use of gradiometric configurations, but the performance is strongly tied to the homogeneity of the sensing elements. This paper presents a new method that uses electronic circuits to modify themore » equivalent impedance of the GMI samples, aiming at homogenizing their phase characteristics and, consequently, improving the performance of gradiometric configurations based on GMI samples. It is also shown a performance comparison between this new method and another homogenization method previously developed.« less

Excited Ejecta in Light of Sight from Eta Car

NASA Technical Reports Server (NTRS)

Vieira, G.; Gull, T. R.; Danks, A.

2003-01-01

In the NUV spectrum of Eta Car, we have resolved many narrow absorption lines of neutral and singly-ionized elements with the Space Telescope Imaging Spectrograph. We report for the first time the detection of interstellar vanadium in absorption, and many highly-excited absorption lines of Fe, Cr, Ti, Ni, Co, Mn, and Mg. These elements, normally tied up in dust grains in the ISM, are located within wall of the Homunculus within 20,000 A.U. of Eta Car. Stellar radiation and stellar wind are interacting with the wall. Dust is likely being modified and/or destroyed. Previous Homunculus studies have demonstrated that nitrogen is overabundant and that carbon and oxygen emission lines are weak, or non-existent. Are the large column densities of these heavy elements due to abundance effects, excitation mechanisms, or modified grains? We may gain insight as Eta Car goes through its spectroscopic minimum in the summer of 2003.

Scientific journal publishes second eratum regarding false information by scientists funded by asbestos interests.

PubMed

Ruff, Kathleen; Mirabelli, Dario; Magnani, Corrado

2016-01-01

In a paper published on Epidemiology, Biostatistics and Public Health, Ilgren et al. claimed that cases of mesothelioma among workers of the Balangero (a municipality of the province of Turin, Northern Italy) chrysotile mine and nearby residents were not caused by chrysotile, but by other forms of asbestos. In support, they cited a reference where no pertaining evidence can be found. One year after the paper, an erratum was published by the journal editors in chief, warning that an erroneous citation was present. The erratum is weak and misleading, concealing the fact that a false statement was supported by such error and that it may serve the interests of the chrysotile industry, by dismissing evidence of chrysotile carcinogenicity. Some of the article authors, of the editors in chief and members of the journal editorial board had financial ties to asbestos interests.

Marine Layer Stratus Study

NASA Astrophysics Data System (ADS)

Wells, Leonard A.

2007-06-01

The intent of this study is to develop a better understanding of the behavior of late spring through early fall marine layer stratus and fog at Vandenberg Air Force Base, which accounts for a majority of aviation forecasting difficulties. The main objective was to use Leipper (1995) study as a starting point to evaluate synoptic and mesoscale processes involved, and identify specific meteorological parameters that affected the behavior of marine layer stratus and fog. After identifying those parameters, the study evaluates how well the various weather models forecast them. The main conclusion of this study is that weak upper-air dynamic features work with boundary layer motions to influence marine layer behavior. It highlights the importance of correctly forecasting the surface temperature by showing how it ties directly to the wind field. That wind field, modified by the local terrain, establishes the low-level convergence and divergence pattern and the resulting marine layer cloud thicknesses and visibilities.

Optimum study designs.

PubMed

Gu, C; Rao, D C

2001-01-01

Because simplistic designs will lead to prohibitively large sample sizes, the optimization of genetic study designs is critical for successfully mapping genes for complex diseases. Creative designs are necessary for detecting and amplifying the usually weak signals for complex traits. Two important outcomes of a study design--power and resolution--are implicitly tied together by the principle of uncertainty. Overemphasis on either one may lead to suboptimal designs. To achieve optimality for a particular study, therefore, practical measures such as cost-effectiveness must be used to strike a balance between power and resolution. In this light, the myriad of factors involved in study design can be checked for their effects on the ultimate outcomes, and the popular existing designs can be sorted into building blocks that may be useful for particular situations. It is hoped that imaginative construction of novel designs using such building blocks will lead to enhanced efficiency in finding genes for complex human traits.

The strength of friendship ties in proximity sensor data.

PubMed

Sekara, Vedran; Lehmann, Sune

2014-01-01

Understanding how people interact and socialize is important in many contexts from disease control to urban planning. Datasets that capture this specific aspect of human life have increased in size and availability over the last few years. We have yet to understand, however, to what extent such electronic datasets may serve as a valid proxy for real life social interactions. For an observational dataset, gathered using mobile phones, we analyze the problem of identifying transient and non-important links, as well as how to highlight important social interactions. Applying the Bluetooth signal strength parameter to distinguish between observations, we demonstrate that weak links, compared to strong links, have a lower probability of being observed at later times, while such links-on average-also have lower link-weights and probability of sharing an online friendship. Further, the role of link-strength is investigated in relation to social network properties.

Bridging the bonding gap: the transition from primates to humans.

PubMed

Dunbar, R I M

2012-07-05

Primate societies are characterized by bonded social relationships of a kind that are rare in other mammal taxa. These bonded relationships, which provide the basis for coalitions, are underpinned by an endorphin mechanism mediated by social grooming. However, bonded relationships of this kind impose constraints on the size of social groups that are possible. When ecological pressures have demanded larger groups, primates have had to evolve new mechanisms to facilitate bonding. This has involved increasing the size of vocal and visual communication repertoires, increasing the time devoted to social interaction and developing a capacity to manage two-tier social relationships (strong and weak ties). I consider the implications of these constraints for the evolution of human social communities and argue that laughter was an early evolutionary innovation that helped bridge the bonding gap between the group sizes characteristic of chimpanzees and australopithecines and those in later hominins.

Structure and dating errors in the geologic time scale and periodicity in mass extinctions

NASA Technical Reports Server (NTRS)

Stothers, Richard B.

1989-01-01

Structure in the geologic time scale reflects a partly paleontological origin. As a result, ages of Cenozoic and Mesozoic stage boundaries exhibit a weak 28-Myr periodicity that is similar to the strong 26-Myr periodicity detected in mass extinctions of marine life by Raup and Sepkoski. Radiometric dating errors in the geologic time scale, to which the mass extinctions are stratigraphically tied, do not necessarily lessen the likelihood of a significant periodicity in mass extinctions, but do spread the acceptable values of the period over the range 25-27 Myr for the Harland et al. time scale or 25-30 Myr for the DNAG time scale. If the Odin time scale is adopted, acceptable periods fall between 24 and 33 Myr, but are not robust against dating errors. Some indirect evidence from independently-dated flood-basalt volcanic horizons tends to favor the Odin time scale.

IVF, same-sex couples and the value of biological ties.

PubMed

Di Nucci, Ezio

2016-12-01

Ought parents, in general, to value being biologically tied to their children? Is it important, in particular, that both parents be biologically tied to their children? I will address these fundamental questions by looking at a fairly new practice within IVF treatments, so-called IVF-with-ROPA (Reception of Oocytes from Partner), which allows lesbian couples to 'share motherhood', with one partner providing the eggs while the other becomes pregnant. I believe that IVF-with-ROPA is, just like other IVF treatments, morally permissible, but here I argue that the increased biological ties which IVF-with-ROPA allows for do not have any particular value beside the satisfaction of a legitimate wish, because there is no intrinsic value in a biological tie between parents and children; further, I argue that equality within parental projects cannot be achieved by redistributing biological ties. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

Angiopoietin–Tie signalling in the cardiovascular and lymphatic systems

PubMed Central

Eklund, Lauri; Kangas, Jaakko; Saharinen, Pipsa

2016-01-01

Endothelial cells that form the inner layer of blood and lymphatic vessels are important regulators of vascular functions and centrally involved in the pathogenesis of vascular diseases. In addition to the vascular endothelial growth factor (VEGF) receptor pathway, the angiopoietin (Ang)–Tie system is a second endothelial cell specific ligand–receptor signalling system necessary for embryonic cardiovascular and lymphatic development. The Ang–Tie system also regulates postnatal angiogenesis, vessel remodelling, vascular permeability and inflammation to maintain vascular homoeostasis in adult physiology. This system is implicated in numerous diseases where the vasculature has an important contribution, such as cancer, sepsis, diabetes, atherosclerosis and ocular diseases. Furthermore, mutations in the TIE2 signalling pathway cause defects in vascular morphogenesis, resulting in venous malformations and primary congenital glaucoma. Here, we review recent advances in the understanding of the Ang–Tie signalling system, including cross-talk with the vascular endothelial protein tyrosine phosphatase (VE-PTP) and the integrin cell adhesion receptors, focusing on the Ang–Tie system in vascular development and pathogenesis of vascular diseases. PMID:27941161

The relationship between perceived discrimination and high-risk social ties among illicit drug users in New York City, 2006-2009.

PubMed

Crawford, Natalie D; Ford, Chandra; Galea, Sandro; Latkin, Carl; Jones, Kandice C; Fuller, Crystal M

2013-01-01

Discrimination can influence risk of disease by promoting unhealthy behaviors (e.g., smoking, alcohol use). Whether it influences the formation of high-risk social ties that facilitate HIV transmission is unclear. Using cross-sectional data from a cohort of illicit drug users, this study examined the association between discrimination based on race, drug use and prior incarceration and risky sex and drug ties. Negative binomial regression models were performed. Participants who reported discrimination based on race and drug use had significantly more sex and drug-using ties. But, after accounting for both racial and drug use discrimination, only racial discrimination was associated with increased sex, drug-using, and injecting ties. Drug users who experience discrimination and subsequently develop more sex and drug-using ties, increase their risk of contracting HIV. Future longitudinal studies illuminating the pathways linking discrimination and social network development may guide intervention development and identify drug-using subpopulations at high risk for disease transmission.

Simulating the thermodynamics of charging in weak polyelectrolytes: the Debye-Hückel limit

NASA Astrophysics Data System (ADS)

Rathee, Vikramjit S.; Sikora, Benjamin J.; Sidky, Hythem; Whitmer, Jonathan K.

2018-01-01

The coil-globule transition in weak (annealed) polyelectrolytes involves a subtle balance of pH, charge strength, and solvation forces. In this work, we utilize a coarse-grained hybrid grand-canonical Monte Carlo and molecular dynamics approach to explore the swelling behavior of weak linear and star polyelectrolytes under different ionic screening conditions and pH. Importantly, we are able to quantify topology-dependent effects in charging which arise at the core of star polymers. Our results are suggestive of suppression of charging in star weak polyelectrolytes in comparison to linear weak polyelectrolytes. Furthermore, we characterize the coil-globule transition in linear and star weak polyelectrolyte through expanded ensemble density-of-states simulations which suggest a change from a first order to second order phase transition moving from linear to star polyelectrolytes. Lastly, we characterize the inhomogeneous charging across the weak star polyelectrolyte through observed shifts in {{Δ }}{{{pK}}}{{o}}, and compare with experimental work. We discuss these results in relation to surfaces functionalized by weak polyelectrolyte brushes and weak polyelectrolyte-based drug delivery applications.

Longitudinal analysis of large social networks: Estimating the effect of health traits on changes in friendship ties

PubMed Central

O'Malley, A James; Christakis, Nicholas A

2011-01-01

We develop novel mixed effects models to examine the role of health traits on the status of peoples' close friendship nominations in the Framingham Heart Study. The health traits considered are both mutable (body mass index (BMI), smoking, blood pressure, body proportion, muscularity, and depression) and, for comparison, basically immutable (height, birth order, personality type, only child, and handedness); and the traits have varying degrees of observability. We test the hypotheses that existing ties (i.e. close friendship nominations) are more likely to dissolve between people with dissimilar (mutable and observable) health traits whereas new ties are more likely to form between those with similar (mutable and observable) traits while controlling for persons' age, gender, geographic separation, and education. The mixed effects models contain random effects for both the nominator (ego) and nominated (alter) persons in a tie to account for the fact that people were involved in multiple relationships and contributed observations at multiple exams. Results for BMI support the hypotheses that people of similar BMI are less likely to dissolve existing ties and more likely to form ties, while smoker to non-smoker ties were the least likely to dissolve and smoker to smoker ties were the most likely to form. We also validated previously known findings regarding homophily on age and gender, and found evidence that homophily also depends upon geographic separation. Copyright © 2011 John Wiley & Sons, Ltd. PMID:21287589

Longitudinal analysis of large social networks: estimating the effect of health traits on changes in friendship ties.

PubMed

O'Malley, A James; Christakis, Nicholas A

2011-04-30

We develop novel mixed effects models to examine the role of health traits on the status of peoples' close friendship nominations in the Framingham Heart Study. The health traits considered are both mutable (body mass index (BMI), smoking, blood pressure, body proportion, muscularity, and depression) and, for comparison, basically immutable (height, birth order, personality type, only child, and handedness); and the traits have varying degrees of observability. We test the hypotheses that existing ties (i.e. close friendship nominations) are more likely to dissolve between people with dissimilar (mutable and observable) health traits whereas new ties are more likely to form between those with similar (mutable and observable) traits while controlling for persons' age, gender, geographic separation, and education. The mixed effects models contain random effects for both the nominator (ego) and nominated (alter) persons in a tie to account for the fact that people were involved in multiple relationships and contributed observations at multiple exams. Results for BMI support the hypotheses that people of similar BMI are less likely to dissolve existing ties and more likely to form ties, while smoker to non-smoker ties were the least likely to dissolve and smoker to smoker ties were the most likely to form. We also validated previously known findings regarding homophily on age and gender, and found evidence that homophily also depends upon geographic separation. Copyright © 2011 John Wiley & Sons, Ltd.

Cross-border ties, nativity, and inflammatory markers in a population-based prospective study of Latino adults.

PubMed

Torres, Jacqueline M; Epel, Elissa S; To, Tu My; Lee, Anne; Aiello, Allison E; Haan, Mary N

2018-05-16

Even after migration, immigrants and their descendants may continue to have ties to family and friends who remain in places of origin. Recent research suggests that these cross-border social ties have implications for health, although this scholarship has been limited to self-reported outcomes. Using data from the Sacramento Area Latino Study on Aging (SALSA), we estimate associations between cross-border social ties and inflammatory biomarkers among Latino adults (n = 1786). We find that immigrants who maintained any cross-border connection to family and friends in Latin America had significantly lower levels of baseline interleukin-6 (IL-6) and C-reactive protein (CRP) compared to their US-born counterparts with no cross-border ties. These results held for values of CRP at five-year follow-up for men only. In contrast, US-born women with cross-border ties to family and friends in Latin America had both significantly higher levels of CRP and significantly lower levels of tumor necrosis factor-alpha (TNF-α) at five-year follow-up relative to their US-born counterparts with no cross-border ties. We find descriptively that men who have cross-border ties are also less likely to be socially isolated within local contexts. Considering place-of-origin social connections may contribute critical nuance to studies of immigrant health, including disparities in inflammatory markers that may serve as indicators of underlying chronic disease. Copyright © 2018 Elsevier Ltd. All rights reserved.

A Strategic Vision and a New Management Approach for the Department of the Navy’s Research, Development, Test and Evaluation (RDT&E) Portfolio

DTIC Science & Technology

2014-08-01

level. The two bolded and underlined aspects of this paradigm are the central topics of this paper. They will be explored and specific...accounts and that ties them together as a coherent whole. This should be of much greater concern than the lack of oversight of non-ACAT programs, the...Research and Engineering) [ ASD R&E]), and with Congress. It has shrunk noticeably over the last several decades as a percentage of the DON topline

Contractors on the Battlefield: A Case Study of the Airborne Reconnaissance Low (ARL) Life-Cycle Logistics Support Contract - March 2000 Through August 2001

DTIC Science & Technology

2001-12-01

military vehicles, so they were forced to go to Heidelberg, Germany, to rent Ford Broncos (equivalent to U.S. Ford Explorers). They were also...several of the technicians had family ties to the area. The unit was relocated to El Paso, Texas, in late 1999. Following the relocation, more than...half of the contractor’s personnel resigned. Several were transferred to South Korea. Many individuals did not want to live in the El Paso area, and

Financing Estonia's unemployment insurance system: problems and prospects.

PubMed

Paas, T; Scannell, N J

2000-01-01

In recent years, favorable media coverage of the glowing employment situation in the United States has been the norm. History, for one, won't permit us, however, to become complacent with what appears on the books to be a rosy economic picture for the nation. Moreover, the mounting recognition that the U.S. economy is inextricably tied to those of other nations--large and small--serves to keep us vigilant. This paper allows us a comparative exploration of the employment conditions in Estonia and the problems and prospects of financing its unemployment insurance program.

Biosocial factors influencing women to become prostitutes in India.

PubMed

Chattopadhyay, M; Bandyopadhyay, S; Duttagupta, C

1994-01-01

Based on materials collected during a study of risk factors associated with cervix cancer among prostitutes in Domjur, Howrah, West Bengal, this report explores various biosocial factors which may lead women to prostitution. When family and marital ties fail or disintegrate for various reasons, the life situations which a woman encounters may themselves generate a "process" of anchorlessness. The failure of family support along with the lack of ability to provide for themselves due to poverty and illiteracy were key factors why the women in this study had adopted prostitution.

Track component property tests : property tests volume 1 : rail, tie, and fasteners.

DOT National Transportation Integrated Search

1979-08-01

This report describes the test procedures and the results of tests on the physical properties of rail, tie and fastener. The properties obtained are the bending rigidity of the tie, bending rigidity of the rail in both the vertical and lateral planes...

Chord Panel Post, Vertical X Bracing & Horizontal Tie Joint ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Chord Panel Post, Vertical X Bracing & Horizontal Tie Joint Detail; Chord Joining Block & Spacer Block Detail; Cross Bracing Joint Detail; Chord Panel Post Diagonal & Horizontal Tie Joint Detail - Jackson Covered Bridge, Spanning Sugar Creek, CR 775N (Changed from Spanning Sugar Creek), Bloomingdale, Parke County, IN

Employees and Creativity: Social Ties and Access to Heterogeneous Knowledge

ERIC Educational Resources Information Center

Huang, Chiung-En; Liu, Chih-Hsing Sam

2015-01-01

This study dealt with employee social ties, knowledge heterogeneity contacts, and the generation of creativity. Although prior studies demonstrated a relationship between network position and creativity, inadequate attention has been paid to network ties and heterogeneity knowledge contacts. This study considered the social interaction processes…

Exploring the Physics of Music with Temperament Studio

NASA Astrophysics Data System (ADS)

Durfee, Dallin; Colton, John

2016-03-01

The physics of waves, resonance, harmonics, and beats has determined how musical instruments are tuned, and has even affected the kinds of music written in different time periods. The laws of physics make it impossible for any fixed scale to have perfect consonance for all chords in all keys, and as a result, various musical scales, or temperaments, have been developed and used throughout history. The study of musical temperament is a rich application of wave physics. It ties several principles together in a context which can be very motivating for students. Furthermore, the topic is accessible to students in introductory classes. We have developed an open source application called Temperament Studio which allows students to explore musical temperament and to hear and measure the effects predicted by wave physics.

46 CFR 112.05-3 - Main-emergency bus-tie.

Code of Federal Regulations, 2013 CFR

2013-10-01

... Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) ELECTRICAL ENGINEERING EMERGENCY LIGHTING AND POWER SYSTEMS General § 112.05-3 Main-emergency bus-tie. Each bus-tie between a main switchboard... other source of electric power, except for interlock systems for momentary transfer of loads; and (c) If...

46 CFR 112.05-3 - Main-emergency bus-tie.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) ELECTRICAL ENGINEERING EMERGENCY LIGHTING AND POWER SYSTEMS General § 112.05-3 Main-emergency bus-tie. Each bus-tie between a main switchboard... other source of electric power, except for interlock systems for momentary transfer of loads; and (c) If...

46 CFR 112.05-3 - Main-emergency bus-tie.

Code of Federal Regulations, 2012 CFR

2012-10-01

... Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) ELECTRICAL ENGINEERING EMERGENCY LIGHTING AND POWER SYSTEMS General § 112.05-3 Main-emergency bus-tie. Each bus-tie between a main switchboard... other source of electric power, except for interlock systems for momentary transfer of loads; and (c) If...

46 CFR 112.05-3 - Main-emergency bus-tie.

Code of Federal Regulations, 2014 CFR

2014-10-01

... Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) ELECTRICAL ENGINEERING EMERGENCY LIGHTING AND POWER SYSTEMS General § 112.05-3 Main-emergency bus-tie. Each bus-tie between a main switchboard... other source of electric power, except for interlock systems for momentary transfer of loads; and (c) If...

What’s Causing Toxicity in Sediments? Results of Twenty Years of Toxicity Identification and Evaluations (TIEs)

EPA Science Inventory

Sediment Toxicity Identification and Evaluation (TIEs) methods have been used for twenty years to identify the causes of toxicity in sediments around the world. We summarized and categorized results of more than 80 peer-reviewed TIE studies into non-ionic organic, cationic, ammo...

A Proposed Performance-Based System for Teacher Interactive Electronic Continuous Professional Development (TIE-CPD)

ERIC Educational Resources Information Center

Razak, Rafiza Abdul; Yusop, Farrah Dina; Idris, Aizal Yusrina; Al-Sinaiyah, Yanbu; Halili, Siti Hajar

2016-01-01

The paper introduces Teacher Interactive Electronic Continuous Professional Development (TIE-CPD), an online interactive training system. The framework and methodology of TIE-CPD are designed with functionalities comparable with existing e-training systems. The system design and development literature offers several methodology and framework…

Diverless tie-in tool gets first test on deepwater line

DOE Office of Scientific and Technical Information (OSTI.GOV)

Knott, D.

1997-03-24

A diverless, deepwater tie-in and repair tool has been developed and successfully tested on the Norwegian Sea`s Haltenpipe project. Den Norske stats oljeselskap AS (Statoil) and Hydratight Ltd., Wolverhampton, U.K., have disclosed details of the technique and installation. Statoil funded development by Hydra-tight of its Morgrip mechanical connector as a diverless pipeline tie-in and repair system for use in water too deep for existing technologies. The paper discusses welding restrictions underwater, metal-to-metal sealing, the Haltenpipe tie-in, and further development plans.

Measurement of Compression Factor and Error Sensitivity Factor of Five Selected Two-Dimensional Facsimile Coding Techniques

DTIC Science & Technology

1979-09-01

et do $a mise en oeuvre done tie r~glon-pilote. La g~n~ralisation ultdrieure do lapplication realis~t dane cette region-pilote depend des reaultats...informiation*, une v~sritable " Banque tie donn(’es", ropartle stir des nioyens detraitoment nationaux et roglonaux, et qui devra rester alinientoe, mime A jour...tiouveaux 4 inettre en place pour aborder la roalisation du aysttme informatif. L’obligation tie fait e appel il des ordinateut’s tie troisi~me gcon

ParTIES: a toolbox for Paramecium interspersed DNA elimination studies.

PubMed

Denby Wilkes, Cyril; Arnaiz, Olivier; Sperling, Linda

2016-02-15

Developmental DNA elimination occurs in a wide variety of multicellular organisms, but ciliates are the only single-celled eukaryotes in which this phenomenon has been reported. Despite considerable interest in ciliates as models for DNA elimination, no standard methods for identification and characterization of the eliminated sequences are currently available. We present the Paramecium Toolbox for Interspersed DNA Elimination Studies (ParTIES), designed for Paramecium species, that (i) identifies eliminated sequences, (ii) measures their presence in a sequencing sample and (iii) detects rare elimination polymorphisms. ParTIES is multi-threaded Perl software available at https://github.com/oarnaiz/ParTIES. ParTIES is distributed under the GNU General Public Licence v3. © The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

Multipronged regulatory functions of a novel endonuclease (TieA) from Helicobacter pylori

PubMed Central

Devi, Savita; Ansari, Suhail A.; Tenguria, Shivendra; Kumar, Naveen; Ahmed, Niyaz

2016-01-01

Helicobacter pylori portrays a classical paradigm of persistent bacterial infections. A well balanced homeostasis of bacterial effector functions and host responses is purported to be the key in achieving long term colonization in specific hosts. H. pylori nucleases have been shown to assist in natural transformation, but their role in virulence and colonization remains elusive. Therefore, it is imperative to understand the involvement of these nucleases in the pathogenesis of H. pylori. Here, we report the multifaceted role of a TNFR-1 interacting endonuclease A (TieA) from H. pylori. tieA expression is differentially regulated in response to environmental stress and post adherence to gastric epithelial cells. Studies with isogenic knockouts of tieA revealed it to be a secretory protein which translocates into the host gastric epithelial cells independent of a type IV secretion system, gets phosphorylated by DNA-PK kinase and auto-phosphorylates as serine kinase. Furthermore, TieA binds to and cleaves DNA in a non-specific manner and promotes Fas mediated apoptosis in AGS cells. Additionally, TieA induced pro-inflammatory cytokine secretion via activation of transcription factor AP-1 and signaled through MAP kinase pathway. Collectively, TieA with its multipronged and moonlighting functions could facilitate H. pylori in maintaining a balance of bacterial adaptation, and elimination by the host responses. PMID:27550181

Expanding Disease Definitions in Guidelines and Expert Panel Ties to Industry: A Cross-sectional Study of Common Conditions in the United States

PubMed Central

Moynihan, Raymond N.; Cooke, Georga P. E.; Doust, Jenny A.; Bero, Lisa; Hill, Suzanne; Glasziou, Paul P.

2013-01-01

Background Financial ties between health professionals and industry may unduly influence professional judgments and some researchers have suggested that widening disease definitions may be one driver of over-diagnosis, bringing potentially unnecessary labeling and harm. We aimed to identify guidelines in which disease definitions were changed, to assess whether any proposed changes would increase the numbers of individuals considered to have the disease, whether potential harms of expanding disease definitions were investigated, and the extent of members' industry ties. Methods and Findings We undertook a cross-sectional study of the most recent publication between 2000 and 2013 from national and international guideline panels making decisions about definitions or diagnostic criteria for common conditions in the United States. We assessed whether proposed changes widened or narrowed disease definitions, rationales offered, mention of potential harms of those changes, and the nature and extent of disclosed ties between members and pharmaceutical or device companies. Of 16 publications on 14 common conditions, ten proposed changes widening and one narrowing definitions. For five, impact was unclear. Widening fell into three categories: creating “pre-disease”; lowering diagnostic thresholds; and proposing earlier or different diagnostic methods. Rationales included standardising diagnostic criteria and new evidence about risks for people previously considered to not have the disease. No publication included rigorous assessment of potential harms of proposed changes. Among 14 panels with disclosures, the average proportion of members with industry ties was 75%. Twelve were chaired by people with ties. For members with ties, the median number of companies to which they had ties was seven. Companies with ties to the highest proportions of members were active in the relevant therapeutic area. Limitations arise from reliance on only disclosed ties, and exclusion of conditions too broad to enable analysis of single panel publications. Conclusions For the common conditions studied, a majority of panels proposed changes to disease definitions that increased the number of individuals considered to have the disease, none reported rigorous assessment of potential harms of that widening, and most had a majority of members disclosing financial ties to pharmaceutical companies. Please see later in the article for the Editors' Summary PMID:23966841

Strong Dollar, Weak Dollar: Foreign Exchange Rates and the U.S. Economy.

ERIC Educational Resources Information Center

Schilling, Tim

Many generalizations sound simple enough--for example, "strong is good, weak is bad"--but they can be confusing when talking about money. This booklet explores how the U.S. dollar and foreign currencies affect each other and how their interaction affects the individual and the economy. The booklet contains the following sections:…

Early Learning and Adaptive Behaviour in Toddlers with Down Syndrome: Evidence for an Emerging Behavioural Phenotype?

ERIC Educational Resources Information Center

Fidler, Deborah; Hepburn, Susan; Rogers, Sally

2006-01-01

Background: Though the Down syndrome behavioural phenotype has been described as involving relative strengths in visuo-spatial processing and sociability, and relative weaknesses in verbal skills and motor planning, the early emergence of this phenotypic pattern of strengths and weaknesses has not yet been fully explored. Method: In this study, we…

Cognitive-Processing Bias in Chinese Student Teachers with Strong and Weak Professional Identity.

PubMed

Wang, Xin-Qiang; Zhu, Jun-Cheng; Liu, Lu; Chen, Xiang-Yu

2017-01-01

Professional identity plays an important role in career development. Although many studies have examined professional identity, differences in cognitive-processing biases between Chinese student teachers with strong and weak professional identity are poorly understood. The current study adopted Tversky's social-cognitive experimental paradigm to explore cognitive-processing biases in Chinese student teachers with strong and weak professional identity. Experiment 1 showed that participants with strong professional identity exhibited stronger positive-coding bias toward positive profession-related life events, relative to that observed in those with weak professional identity. Experiment 2 showed that participants with strong professional identity exhibited greater recognition bias for previously read items, relative to that observed in those with weak professional identity. Overall, the results suggested that participants with strong professional identity exhibited greater positive cognitive-processing bias relative to that observed in those with weak professional identity.

Cognitive-Processing Bias in Chinese Student Teachers with Strong and Weak Professional Identity

PubMed Central

Wang, Xin-qiang; Zhu, Jun-cheng; Liu, Lu; Chen, Xiang-yu

2017-01-01

Professional identity plays an important role in career development. Although many studies have examined professional identity, differences in cognitive-processing biases between Chinese student teachers with strong and weak professional identity are poorly understood. The current study adopted Tversky’s social-cognitive experimental paradigm to explore cognitive-processing biases in Chinese student teachers with strong and weak professional identity. Experiment 1 showed that participants with strong professional identity exhibited stronger positive-coding bias toward positive profession-related life events, relative to that observed in those with weak professional identity. Experiment 2 showed that participants with strong professional identity exhibited greater recognition bias for previously read items, relative to that observed in those with weak professional identity. Overall, the results suggested that participants with strong professional identity exhibited greater positive cognitive-processing bias relative to that observed in those with weak professional identity. PMID:28555123

Effect of flexibility on the growth of concentration fluctuations in a suspension of sedimenting fibers: Particle simulations

DOE Office of Scientific and Technical Information (OSTI.GOV)

Manikantan, Harishankar; Saintillan, David

2016-01-15

Three-dimensional numerical simulations are performed to study the stability of a sedimenting suspension of weakly flexible fibers. It is well known that a suspension of rigid rods sedimenting under gravity at low Reynolds number is unstable to concentration fluctuations owing to hydrodynamic interactions. Flexible fibers, however, reorient while settling and even weak flexibility can alter their collective dynamics. In our recent work [Manikantan et al., “The instability of a sedimenting suspension of weakly flexible fibres,” J. Fluid Mech. 756, 935–964 (2014)], we developed a mean-field theory to predict the linear stability of such a system. Here, we verify these predictionsmore » using accurate and efficient particle simulations based on a slender-body model. We also demonstrate the mechanisms by which flexibility-induced reorientation alters suspension microstructure, and through it, its stability. Specifically, we first show that the anisotropy of the base state in the case of a suspension of flexible fibers has a destabilizing effect compared to a suspension of rigid rods. Second, a conflicting effect of flexibility is also shown to suppress particle clustering and slow down the growth of the instability. The relative magnitude of filament flexibility and rotational Brownian motion dictates which effect dominates, and our simulations qualitatively follow theoretically predicted trends. The mechanism for either effects is tied to the flexibility-induced reorientation of particles, which we illustrate using velocity and orientation statistics from our simulations. Finally, we also show that, in the case of an initially homogeneous and isotropic suspension, flexibility always acts to suppress the growth of the instability.« less

The absent bow tie sign in bucket-handle tears of the menisci in the knee.

PubMed

Helms, C A; Laorr, A; Cannon, W D

1998-01-01

Bucket-handle tears of the menisci are one of the most frequently missed diagnoses in MR examinations of the knee. This article describes the "absent bow tie sign," which can be used to identify bucket-handle tears on routine MR examinations of the knee. The arthroscopic surgical reports (n = 350) from a single orthopedic surgeon's practice during a 24-month period were examined for patients who had a diagnosis of bucket-handle tear and who underwent MR imaging before surgery (n = 32). The MR examinations were retrospectively evaluated for the presence of a bow tie sign. The bow tie sign was considered normal when two sagittal images showed the body segment (a bow tie appearance). The bow tie sign was considered abnormal, consistent with a bucket-handle tear, when only one or no body segment was seen (the absent bow tie sign). Coronal images were evaluated for a truncated meniscus. Also, each MR examination was scrutinized for a displaced fragment and a double posterior cruciate ligament (PCL) sign. Thirty-three bucket-handle tears were found at arthroscopy in 32 patients. One patient had tears of the medial and lateral menisci. The absent bow tie sign was seen in 32 of the 33 cases (sensitivity, 97%) and correlated with the medial or lateral meniscus that was reported torn at arthroscopy. The single false-negative result occurred in a patient with a nondisplaced bucket-handle tear. The findings in 31 contralateral normal menisci were all negative for an absent bow tie sign (specificity, 100%). A displaced fragment was found in 30 (94%) of 32 cases. The coronal images showed a truncated meniscus in 21 (64%) of 33 cases. A double PCL sign was seen in 10 (30%) of 33 cases. The absent bow tie sign is an easily applied finding that can be used with good sensitivity to diagnose bucket-handle tears of the menisci on MR imaging. This sign has a higher accuracy rate than other findings common with bucket-handle tears, such as displaced fragments, a truncated appearance of the meniscus on coronal images, and the double PCL sign.

Financial ties and concordance between results and conclusions in meta-analyses: retrospective cohort study.

PubMed

Yank, Veronica; Rennie, Drummond; Bero, Lisa A

2007-12-08

To determine whether financial ties to one drug company are associated with favourable results or conclusions in meta-analyses on antihypertensive drugs. Retrospective cohort study. Meta-analyses published up to December 2004 that were not duplicates and evaluated the effects of antihypertensive drugs compared with any comparator on clinical end points in adults. Financial ties were categorised as one drug company compared with all others. The main outcomes were the results and conclusions of meta-analyses, with both outcomes separately categorised as being favourable or not favourable towards the study drug. We also collected data on characteristics of meta-analyses that the literature suggested might be associated with favourable results or conclusions. 124 meta-analyses were included in the study, 49 (40%) of which had financial ties to one drug company. On univariate logistic regression analyses, meta-analyses of better methodological quality were more likely to have favourable results (odds ratio 1.16, 95% confidence interval 1.07 to 1.27). Although financial ties to one drug company were not associated with favourable results, such ties constituted the only characteristic significantly associated with favourable conclusions (4.09, 1.30 to 12.83). When controlling for other characteristics of meta-analyses in multiple logistic regression analyses, meta-analyses that had financial ties to one drug company remained more likely to report favourable conclusions (5.11, 1.54 to 16.92). Meta-analyses on antihypertensive drugs and with financial ties to one drug company are not associated with favourable results but are associated with favourable conclusions.

Software With Strong Ties to Space

NASA Technical Reports Server (NTRS)

2003-01-01

TieFlow is a simple but powerful business process improvement solution. It can automate and simplify any generic or industry-specific work process, helping organizations to transform work inefficiencies and internal operations involving people, paper, and procedures into a streamlined, well-organized, electronicbased process. TieFlow increases business productivity by improving process cycle times. The software can expedite generic processes in the areas of product design and development, purchase orders, expense reports, benefits enrollment, budgeting, hiring, and sales. It can also shore up vertical market processes such as claims processing, loan application and processing, health care administration, contract management, and advertising agency traffic. The processes can be easily and rapidly captured in a graphical manner and enforced together with rules pertaining to assignments that need to be performed. Aside from boosting productivity, TieFlow also reduces organizational costs and errors. TieFlow was developed with Small Business Innovation Research (SBIR) assistance from Johnson. The SBIR support entitles all Federal Government agencies to utilize the TieFlow software technology free of charge. Tietronix emphasizes that TieFlow is an outstanding workflow resource that could produce dramatic productivity and cost improvements for all agencies, just as it has done and continues to do for NASA. The Space Agency is currently using the software throughout several mission-critical offices, including the Mission Operations Directorate and the Flight Director s Office, for worldwide participation of authorized users in NASA processes. At the Flight Director s Office, TieFlow allows personnel to electronically submit and review changes to the flight rules carried out during missions.

Clinical evaluation of the endothelial tie-2 crossmatch in ABO compatible and ABO incompatible renal transplants.

PubMed

Kafetzi, Maria L; Boletis, John N; Melexopoulou, Christine A; Tsakris, Athanassios; Iniotaki, Aliki G; Doxiadis, Ilias I N

2013-11-01

The necessity of detection of other than the classical major histocompatibility complex (MHC) and MHC class I-related chain A (MICA) directed antibodies prior to organ transplantation has already been repeatedly reported. A commercial flow cytometric endothelial crossmatch (CM) using isolated peripheral blood tie-2 positive cells provides a tool to detect non-MHC antibodies in addition to antibodies directed to MHC class I and II. The vast majority of circulating tie-2 positive cells expresses HLA-DR but not the A, B blood group antigens. Tie-2 cells are circulating surrogate endothelial cells. In this retrospective study we evaluated the endothelial CM in 51 renal transplantations, 30 with ABO compatible grafts and 21 with ABO incompatible grafts. Fifteen of the ABO compatible recipients (group A) developed unexplained rejection episodes (RE) while the remaining 15 had no RE (group B). Five cases of group A and none of group B had a positive tie-2 CM before transplantation (p=0.042). A positive tie-2 CM was also correlated with graft failure in ABO compatible transplants (p=0.02). No significant correlation was found between a positive pre-transplant tie-2 CM and RE in the ABO incompatible group. This study strongly suggest that a positive tie-2 CM may predict post-transplantation complications in ABO compatible grafts while negative reactions are not predictive. The test is not significantly correlated with RE in ABO incompatible grafts possibly due to applied desensitization. Copyright © 2013 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.

[A SWOT (strengths, weaknesses, opportunities, threats) analysis of the current immunization program in Zhejiang Province].

PubMed

He, Han-Qing; Ling, Luo-Ya; Xu, Xu-Qing

2009-02-01

To know the status of Immunization program in Zhejiang Province. The investigation on immunization program in zhejiang province was conducted, and the SWOT analysis was corducted to make a comprehensive evaluation. 11 cities, 22 counties and 44 towns were investigated in this study, and the current immunization program in Zhejiang province were explored by SWOT analysis. The SWOT Matrix, includes SO (strength-opportunity), ST (strength-threat), WO (weakness-opportunity) and WT (weakness-threat) can apply to make optimal strategy for the development of expanded program on immunization.

Information-reality complementarity in photonic weak measurements

NASA Astrophysics Data System (ADS)

Mancino, Luca; Sbroscia, Marco; Roccia, Emanuele; Gianani, Ilaria; Cimini, Valeria; Paternostro, Mauro; Barbieri, Marco

2018-06-01

The emergence of realistic properties is a key problem in understanding the quantum-to-classical transition. In this respect, measurements represent a way to interface quantum systems with the macroscopic world: these can be driven in the weak regime, where a reduced back-action can be imparted by choosing meter states able to extract different amounts of information. Here we explore the implications of such weak measurement for the variation of realistic properties of two-level quantum systems pre- and postmeasurement, and extend our investigations to the case of open systems implementing the measurements.

49 CFR 1242.15 - Roadway, tunnels and subways, bridges and culverts, ties, rails, other track material, ballast...

Code of Federal Regulations, 2012 CFR

2012-10-01

... 49 Transportation 9 2012-10-01 2012-10-01 false Roadway, tunnels and subways, bridges and culverts, ties, rails, other track material, ballast, track laying and surfacing, and road property damaged... culverts, ties, rails, other track material, ballast, track laying and surfacing, and road property damaged...

49 CFR 1242.15 - Roadway, tunnels and subways, bridges and culverts, ties, rails, other track material, ballast...

Code of Federal Regulations, 2011 CFR

2011-10-01

... 49 Transportation 9 2011-10-01 2011-10-01 false Roadway, tunnels and subways, bridges and culverts, ties, rails, other track material, ballast, track laying and surfacing, and road property damaged... culverts, ties, rails, other track material, ballast, track laying and surfacing, and road property damaged...

49 CFR 1242.15 - Roadway, tunnels and subways, bridges and culverts, ties, rails, other track material, ballast...

Code of Federal Regulations, 2013 CFR

2013-10-01

... 49 Transportation 9 2013-10-01 2013-10-01 false Roadway, tunnels and subways, bridges and culverts, ties, rails, other track material, ballast, track laying and surfacing, and road property damaged... culverts, ties, rails, other track material, ballast, track laying and surfacing, and road property damaged...

49 CFR 1242.15 - Roadway, tunnels and subways, bridges and culverts, ties, rails, other track material, ballast...

Code of Federal Regulations, 2014 CFR

2014-10-01

... 49 Transportation 9 2014-10-01 2014-10-01 false Roadway, tunnels and subways, bridges and culverts, ties, rails, other track material, ballast, track laying and surfacing, and road property damaged... culverts, ties, rails, other track material, ballast, track laying and surfacing, and road property damaged...

Experimental Effects of Program Management Approach on Teachers' Professional Ties and Social Capital

ERIC Educational Resources Information Center

Quinn, David M.; Kim, James S.

2018-01-01

Theory and empirical work suggest that teachers' social capital influences school improvement efforts. Social ties are prerequisite for social capital, yet little causal evidence exists on how malleable factors, such as instructional management approaches, affect teachers' ties. In this cluster-randomized trial, we apply a decision-making…

Dissemination Package for Transition into Electronics (TIE) Project, October 1979-June 1980.

ERIC Educational Resources Information Center

Evergreen Valley Coll., San Jose, CA.

This dissemination package consists of a variety of advertising materials, forms, questionnaires, tests, and handouts developed as a part of the Transition into Electronics (TIE) Project. (The TIE Project was a project that developed, implemented, and evaluated a model designed to encourage persons to pursue education and training leading to…

How University Students with Reading Difficulties Are Supported in Achieving Their Goals

ERIC Educational Resources Information Center

Stack-Cutler, Holly L.; Parrila, Rauno K.; Jokisaari, Markku; Nurmi, Jari-Erik

2015-01-01

We examine (a) what social ties university students with a history of reading difficulty (RD) report assisting them to achieve their goals, (b) outlets available for developing social ties, (c) resources mobilized within these relationships, and (d) the impact of social ties' status on academic achievement. Participants were 107 university…

Vibration Testing of Electrical Cables to Quantify Loads at Tie-Down Locations

NASA Technical Reports Server (NTRS)

Dutson, Joseph D.

2013-01-01

The standard method for defining static equivalent structural load factors for components is based on Mile s equation. Unless test data is available, 5% critical damping is assumed for all components when calculating loads. Application of this method to electrical cable tie-down hardware often results in high loads, which often exceed the capability of typical tie-down options such as cable ties and P-clamps. Random vibration testing of electrical cables was used to better understand the factors that influence component loads: natural frequency, damping, and mass participation. An initial round of vibration testing successfully identified variables of interest, checked out the test fixture and instrumentation, and provided justification for removing some conservatism in the standard method. Additional testing is planned that will include a larger range of cable sizes for the most significant contributors to load as variables to further refine loads at cable tie-down points. Completed testing has provided justification to reduce loads at cable tie-downs by 45% with additional refinement based on measured cable natural frequencies.

Toward a Dynamic Conceptualization of Social Ties and Context: Implications for Understanding Immigrant and Latino Health

PubMed Central

Schulz, Amy J.

2009-01-01

Researchers have posited that social ties and social support may contribute to better-than-expected health outcomes among Mexican immigrants vis-à-vis their US-born counterparts. However, in our review of studies examining social ties and health by immigration-related variables among this group, we found little support for this hypothesis. To better understand the social factors that contribute to the health of Mexicans in the United States, we conducted a qualitative analysis of social relationships and social context among first- and second-generation Mexican women. Our results highlight the interplay between immigration processes and social ties, draw attention to the importance of identity support and transnational social relationships, and suggest ways to reconceptualize the relationship between social contexts, social ties, and immigrant and Latino health. PMID:19833986

Fiber Optic Tamper Indicating Enclosure (TIE); A Case Study in Authentication

DOE Office of Scientific and Technical Information (OSTI.GOV)

Anheier, Norman C.; Benz, Jacob M.; Tanner, Jennifer E.

2015-07-15

A robust fiber optic-based tamper-indicating enclosure (TIE) has been developed by PNNL through funding by the National Nuclear Security Administration Office of Nuclear Verification over the past few years. The objective of this work is to allow monitors to have confidence in both the authenticity and integrity of the TIE and the monitoring equipment inside, throughout the time it may be located at a host facility. Incorporating authentication features into the design were the focus of fiscal year 2014 development efforts. Throughout the development process, modifications have been made to the physical TIE design based on lessons learned via exercisesmore » and expert elicitation. The end result is a robust and passive TIE which can be utilized to protect monitoring party equipment left in a host facility.« less

Creative benefits from well-connected leaders: leader social network ties as facilitators of employee radical creativity.

PubMed

Venkataramani, Vijaya; Richter, Andreas W; Clarke, Ronald

2014-09-01

Employee radical creativity critically depends on substantive informational resources from others across the wider organization. We propose that the social network ties of employees' immediate leaders assume a central role in garnering these resources, thereby fostering their employees' radical creativity both independent of and interactively with employees' own network ties. Drawing on data from 214 employees working in 30 teams of a public technology and environmental services organization, we find that team leaders' betweenness centrality in the idea network within their teams as well as among their peer leaders provides creative benefits beyond employees' own internal and external ties. Further, employees' and leaders' ties within and external to the team interactively predict employee radical creativity. Implications for theory and practice are discussed. PsycINFO Database Record (c) 2014 APA, all rights reserved.

Industry ties in otolaryngology: initial insights from the physician payment sunshine act.

PubMed

Rathi, Vinay K; Samuel, Andre M; Mehra, Saral

2015-06-01

To characterize nonresearch payments made by industry to otolaryngologists in order to explore how the potential for conflicts of interests varies among otolaryngologists and compares between otolaryngologists and other surgical specialists. Retrospective cross-sectional database analysis. Open Payments program database recently released by Centers for Medicare and Medicaid Services. Surgeons nationwide who were identified as receiving nonresearch payment from industry in accordance with the Physician Payment Sunshine Act. The proportion of otolaryngologists receiving payment, the mean payment per otolaryngologist, and the standard deviation thereof were determined using the Open Payments database and compared to other surgical specialties. Otolaryngologists were further compared by specialization, census region, sponsor, and payment amount. Less than half of otolaryngologists (48.1%) were reported as receiving payments over the study period, the second smallest proportion among surgical specialties. Otolaryngologists received the lowest mean payment per compensated individual ($573) compared to other surgical specialties. Although otolaryngology had the smallest variance in payment among surgical specialties (SD, $2806), the distribution was skewed by top earners; the top 10% of earners accounted for 87% ($2,199,254) of all payment to otolaryngologists. Otolaryngologists in the West census region were less likely to receive payments (38.6%, P < .001). Over the study period, otolaryngologists appeared to have more limited financial ties with industry compared to other surgeons, though variation exists within otolaryngology. Further refinement of the Open Payments database is needed to explore differences between otolaryngologists and leverage payment information as a tool for self-regulation. © American Academy of Otolaryngology—Head and Neck Surgery Foundation 2015.

Self-Regulatory Strategies in Daily Life: Selection, Optimization, and Compensation and Everyday Memory Problems

PubMed Central

Stephanie, Robinson; Margie, Lachman; Elizabeth, Rickenbach

2015-01-01

The effective use of self-regulatory strategies, such as selection, optimization, and compensation (SOC) requires resources. However, it is theorized that SOC use is most advantageous for those experiencing losses and diminishing resources. The present study explored this seeming paradox within the context of limitations or constraints due to aging, low cognitive resources, and daily stress in relation to everyday memory problems. We examined whether SOC usage varied by age and level of constraints, and if the relationship between resources and memory problems was mitigated by SOC usage. A daily diary paradigm was used to explore day-to-day fluctuations in these relationships. Participants (n=145, ages 22 to 94) completed a baseline interview and a daily diary for seven consecutive days. Multilevel models examined between- and within-person relationships between daily SOC use, daily stressors, cognitive resources, and everyday memory problems. Middle-aged adults had the highest SOC usage, although older adults also showed high SOC use if they had high cognitive resources. More SOC strategies were used on high stress compared to low stress days. Moreover, the relationship between daily stress and memory problems was buffered by daily SOC use, such that on high-stress days, those who used more SOC strategies reported fewer memory problems than participants who used fewer SOC strategies. The paradox of resources and SOC use can be qualified by the type of resource-limitation. Deficits in global resources were not tied to SOC usage or benefits. Conversely, under daily constraints tied to stress, the use of SOC increased and led to fewer memory problems. PMID:26997686

Ties that bind: multiple relationships between clinical researchers and the pharmaceutical industry.

PubMed

Henry, David; Doran, Evan; Kerridge, Ian; Hill, Suzanne; McNeill, Paul M; Day, Richard

2005-11-28

It is believed that pharmaceutical industry sponsorship of clinical research leads to the development of multiple ties between clinicians and the pharmaceutical industry. To quantify this relationship we conducted a survey of medical specialists listed in the Medical Directory of Australia in 2002 and 2003. A questionnaire was mailed that elicited information about all aspects of research relationships between clinicians and pharmaceutical companies. The odds of reporting multiple additional ties (financial and professional) with pharmaceutical companies by clinicians who had an active research relationship were compared with those who did not. All clinicians who returned a completed questionnaire about their research activities were included in the study. A questionnaire was mailed to 2120 medical specialists; 823 (39%) responded. Of these, 338 (41%) reported involvement in industry-sponsored research in the previous year. They were more likely than others to have been offered industry-sponsored items or activities valued at more than 500 AU dollars (>382 US dollars; odds ratio [OR], 3.5; 95% confidence interval [CI], 2.6-4.7) and support for attending international conferences (OR, 5.4; 95% CI, 3.9-7.4). The strongest associations were seen for acting as a paid consultant to industry (OR, 9.0; 95% CI, 3.9-20.4) and for membership on advisory boards (OR, 6.9; 95% CI, 5.1-9.6). There was a strong relationship between research collaboration and accumulation of industry ties. For 1 additional tie the OR was 2.2 (95% CI, 1.2-3.8) and rose to 6.3 (95% CI, 3.5-11.1) with 3 ties and 41.8 (95% CI, 14.5-143.4) with 6 or more ties. Medical specialists who have research relationships with the pharmaceutical industry are much more likely to have multiple additional ties than those who do not have research relationships. Institutional review should discourage clinical researchers from developing multiple ties.

The centrality of social ties to climate migration and mental health.

PubMed

Torres, Jacqueline M; Casey, Joan A

2017-07-06

Climate change-related hazards and disasters, known to adversely impact physical and mental health outcomes, are also expected to result in human migration above current levels. Environmentally-motivated migration and displacement may lead to the disruption of existing social ties, with potentially adverse consequences for mobile populations as well as their family members who remain in places of origin. We propose that the disruption of social ties is a key mechanism by which climate-related migration may negatively impact mental health, in particular. Existing social ties may provide social and material resources that buffer mental health stressors related to both prolonged and acute climate events. Preparation for such events may also strengthen these same ties and protect mental health. Communities may leverage social ties, first to mitigate climate change, and second, to adapt and rebuild post-disaster in communities of origin. Additionally, social ties can inform migration decisions and destinations. For example, scholars have found that the drought-motivated adaptive migration of West African Fulbe herders only occurred because of the long-term development of social networks between migrants and non-migrants through trade and seasonal grazing. On the other hand, social ties do not always benefit mental health. Some migrants, including those from poor regions or communities with no formal safety net, may face considerable burden to provide financial and emotional resources to family members who remain in countries of origin. In destination communities, migrants often face significant social marginalization. Therefore, policies and programs that aim to maintain ongoing social ties among migrants and their family and community members may be critically important in efforts to enhance population resilience and adaptation to climate change and to improve mental health outcomes. Several online platforms, like Refugee Start Force, serve to integrate refugees by connecting migrants directly to people and services in destination communities. These efforts may increasingly draw upon novel technologies to support and maintain social networks in the context of population mobility due to climatic and other factors.

N Channel JFET Based Digital Logic Gate Structure

NASA Technical Reports Server (NTRS)

Krasowski, Michael J (Inventor)

2013-01-01

An apparatus is provided that includes a first field effect transistor with a source tied to zero volts and a drain tied to voltage drain drain (Vdd) through a first resistor. The apparatus also includes a first node configured to tie a second resistor to a third resistor and connect to an input of a gate of the first field effect transistor in order for the first field effect transistor to receive a signal. The apparatus also includes a second field effect transistor configured as a unity gain buffer having a drain tied to Vdd and an uncommitted source.

Two-phase pressure drop reduction BWR assembly design

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dix, G.E.; Crowther, R.L.; Colby, M.J.

1992-05-12

This patent describes a boiling water reactor having discrete bundles of fuel rods confined within channel enclosed fuel assemblies, an improvement to a fuel bundle assembly for placement in the reactor. It comprises a fuel channel having vertically extending walls forming a continuous channel around a fuel assembly volume, the channel being open at the bottom end for engagement to a lower tie plate and open at the upper end for engagement to an upper tie plate; rods for placement within the chamber, each the rod containing fissile material for producing nuclear reaction when in the presence of sufficient moderatedmore » neutron flux; a lower tie plate for supporting the bundle of rods within the channel, the lower tie plate for supporting the bundle of rods within the channel, the lower tie plate joining the bottom of the channel to close the bottom end of the channel, the lower tie plate providing defined apertures for the inflow of water in the channel between the rods for the generating of steam during the nuclear reaction; the plurality of fuel rods extending from the lower tie plate wherein a single phase region of the water in the bundle is defined to an upward portion of the bundle wherein a two phase region of the water and steam in the bundle is defined during nuclear steam generating reaction in the fuel bundle.« less

Estimation of Model's Marginal likelihood Using Adaptive Sparse Grid Surrogates in Bayesian Model Averaging

NASA Astrophysics Data System (ADS)

Zeng, X.

2015-12-01

A large number of model executions are required to obtain alternative conceptual models' predictions and their posterior probabilities in Bayesian model averaging (BMA). The posterior model probability is estimated through models' marginal likelihood and prior probability. The heavy computation burden hinders the implementation of BMA prediction, especially for the elaborated marginal likelihood estimator. For overcoming the computation burden of BMA, an adaptive sparse grid (SG) stochastic collocation method is used to build surrogates for alternative conceptual models through the numerical experiment of a synthetical groundwater model. BMA predictions depend on model posterior weights (or marginal likelihoods), and this study also evaluated four marginal likelihood estimators, including arithmetic mean estimator (AME), harmonic mean estimator (HME), stabilized harmonic mean estimator (SHME), and thermodynamic integration estimator (TIE). The results demonstrate that TIE is accurate in estimating conceptual models' marginal likelihoods. The BMA-TIE has better predictive performance than other BMA predictions. TIE has high stability for estimating conceptual model's marginal likelihood. The repeated estimated conceptual model's marginal likelihoods by TIE have significant less variability than that estimated by other estimators. In addition, the SG surrogates are efficient to facilitate BMA predictions, especially for BMA-TIE. The number of model executions needed for building surrogates is 4.13%, 6.89%, 3.44%, and 0.43% of the required model executions of BMA-AME, BMA-HME, BMA-SHME, and BMA-TIE, respectively.

Multipronged regulatory functions of a novel endonuclease (TieA) from Helicobacter pylori.

PubMed

Devi, Savita; Ansari, Suhail A; Tenguria, Shivendra; Kumar, Naveen; Ahmed, Niyaz

2016-11-02

Helicobacter pylori portrays a classical paradigm of persistent bacterial infections. A well balanced homeostasis of bacterial effector functions and host responses is purported to be the key in achieving long term colonization in specific hosts. H. pylori nucleases have been shown to assist in natural transformation, but their role in virulence and colonization remains elusive. Therefore, it is imperative to understand the involvement of these nucleases in the pathogenesis of H. pylori Here, we report the multifaceted role of a TNFR-1 interacting endonuclease A (TieA) from H. pylori. tieA expression is differentially regulated in response to environmental stress and post adherence to gastric epithelial cells. Studies with isogenic knockouts of tieA revealed it to be a secretory protein which translocates into the host gastric epithelial cells independent of a type IV secretion system, gets phosphorylated by DNA-PK kinase and auto-phosphorylates as serine kinase. Furthermore, TieA binds to and cleaves DNA in a non-specific manner and promotes Fas mediated apoptosis in AGS cells. Additionally, TieA induced pro-inflammatory cytokine secretion via activation of transcription factor AP-1 and signaled through MAP kinase pathway. Collectively, TieA with its multipronged and moonlighting functions could facilitate H. pylori in maintaining a balance of bacterial adaptation, and elimination by the host responses. © The Author(s) 2016. Published by Oxford University Press on behalf of Nucleic Acids Research.

Validation of the Chinese Strengths and Weaknesses of ADHD-Symptoms and Normal-Behaviors Questionnaire in Hong Kong

ERIC Educational Resources Information Center

Lai, Kelly Y. C.; Leung, Patrick W. L.; Luk, Ernest S. L.; Wong, Ann S. Y.; Law, Lawrence S. C.; Ho, Karen K. Y.

2013-01-01

Objective: Unlike rating scales that focus on the severity of ADHD symptoms, the Strengths and Weaknesses of ADHD-Symptoms and Normal-Behaviors (SWAN) rating scale is phrased in neutral or positive terms for carers to compare the index child's behaviors with that of their peers. This study explores its psychometric properties when applied to…

Exploring teachers' perspectives on the impact of out-of-school science-based programs for secondary level physics classrooms in Nebraska

NASA Astrophysics Data System (ADS)

Baquerizo-Birth, Marisol

This exploratory phenomenological study investigates the lived experiences of six high school physics teachers in Nebraska regarding their perceptions on the impact of participating in a science-based out-of-school program. By exploring the research question, we discover how this experience relates to these teachers' self-concept and professional growth. Open-ended, semi-structured, one-on-one interviews are used as the data collection method to explore teachers' perceptions. Responses reveal that teachers participating in the Cosmic Ray Observatory Project (CROP) as a means of exploring advanced, extracurricular physics projects perceive their participation as an opportunity for enrichment, collaboration, helping their students, and empowerment. Intertwined in the presented narratives, teachers refer to their schools' limited administrative support as a source of struggle tied to the challenge of balancing school and teaching responsibilities with CROP participants' responsibilities. This study proposes teachers must feel confident with their specific subject area to achieve a progressive view of self, and that supplemental professional development opportunities are crucial to physics teaching.

Is it time for integration of surgical skills simulation into the United Kingdom undergraduate medical curriculum? A perspective from King's College London School of Medicine.

PubMed

Hamaoui, Karim; Sadideen, Hazim; Saadeddin, Munir; Onida, Sarah; Hoey, Andrew W; Rees, John

2013-01-01

Changes in undergraduate medical curricula, combined with reforms in postgraduate education, have training implications for surgical skills acquisition in a climate of reduced clinical exposure. Confidence and prior experience influences the educational impact of learning. Currently there is no basic surgical skills (BSS) programme integrated into undergraduate curricula in the United Kingdom. We explored the role of a dedicated BSS programme for undergraduates in improving confidence and influencing careers in King's College London School of Medicine, and the programme was evaluated. A programme was designed in-line with the established Royal College of Surgeons course. Undergraduates were taught four key skills over four weeks: knot-tying, basic-suturing, tying-at-depth and chest-drain insertion, using low-fidelity bench-top models. A Likert-style questionnaire was designed to determine educational value and influence on career choice. Qualitative data was collected. Only 29% and 42% of students had undertaken previous practice in knot-tying and basic suturing, respectively. 96% agreed that skills exposure prior to starting surgical rotations was essential and felt a dedicated course would augment undergraduate training. There was a significant increase in confidence in the practice and knowledge of all skills taught (p<0.01), with a greater motivation to be actively involved in the surgical firm and theatres. A simple, structured BSS programme can increase the confidence and motivation of students. Early surgical skills targeting is valuable for students entering surgical, related allied, and even traditionally non-surgical specialties such as general practice. Such experience can increase the confidence of future junior doctors and trainees. We advocate the introduction of a BSS programme into United Kingdom undergraduate curricula.

Is it time for integration of surgical skills simulation into the United Kingdom undergraduate medical curriculum? A perspective from King’s College London School of Medicine

PubMed Central

2013-01-01

Purpose: Changes in undergraduate medical curricula, combined with reforms in postgraduate education, have training implications for surgical skills acquisition in a climate of reduced clinical exposure. Confidence and prior experience influences the educational impact of learning. Currently there is no basic surgical skills (BSS) programme integrated into undergraduate curricula in the United Kingdom. We explored the role of a dedicated BSS programme for undergraduates in improving confidence and influencing careers in King’s College London School of Medicine, and the programme was evaluated. Methods: A programme was designed in-line with the established Royal College of Surgeons course. Undergraduates were taught four key skills over four weeks: knot-tying, basic-suturing, tying-at-depth and chest-drain insertion, using low-fidelity bench-top models. A Likert-style questionnaire was designed to determine educational value and influence on career choice. Qualitative data was collected. Results: Only 29% and 42% of students had undertaken previous practice in knot-tying and basic suturing, respectively. 96% agreed that skills exposure prior to starting surgical rotations was essential and felt a dedicated course would augment undergraduate training. There was a significant increase in confidence in the practice and knowledge of all skills taught (p<0.01), with a greater motivation to be actively involved in the surgical firm and theatres. Conclusion: A simple, structured BSS programme can increase the confidence and motivation of students. Early surgical skills targeting is valuable for students entering surgical, related allied, and even traditionally non-surgical specialties such as general practice. Such experience can increase the confidence of future junior doctors and trainees. We advocate the introduction of a BSS programme into United Kingdom undergraduate curricula. PMID:24498471

Sibling support and the educational prospects of young adults in Malawi

PubMed Central

Trinitapoli, Jenny; Yeatman, Sara; Fledderjohann, Jasmine

2014-01-01

BACKGROUND Extended kin networks are an important social and economic resource in Africa. Existing research has focused primarily on intergenerational ties, but much less is known about “lateral” ties, such as those between siblings. In contexts of high adult mortality (i.e., fewer parents and grandparents) sibling interdependencies may assume heightened importance, especially during the transition to adulthood. OBJECTIVE In this paper, we extend the resource dilution perspective that dominates research on sibling relationships in early childhood and propose an alternate framework in which siblings represent a source of economic support that contributes positively to educational outcomes at later stages of the life course. METHODS We draw upon longitudinal data from young adults (age 15–18) in southern Malawi to assess the scope and magnitude of economic transfers among sibship sets. We then explore the relationships between sibship size, net economic transfers between siblings, and four measures of educational progress. RESULTS First, exchanges of economic support between siblings are pervasive in the Malawian context and patterned, especially by birth order. Second, economic support from siblings is positively associated with educational attainment, as well as with the odds of being at grade level in school, both contemporaneously and prospectively. CONCLUSIONS During young-adulthood, economic support from siblings acts as a buffer against the negative association between sibship size and schooling outcomes that has been documented at earlier ages. COMMENTS We question the established notion that siblings unilaterally subtract from resource pools, and argue that sibling support may be consequential for a wide range of demographic outcomes in a variety of cultural contexts. Our findings point to the need for additional research on the importance of lateral kinship ties across cultural settings and throughout the life course. PMID:24855450

The location of Airy-0, the Mars prime meridian reference, from stereo photogrammetric processing of THEMIS IR imaging and digital elevation data

NASA Astrophysics Data System (ADS)

Duxbury, T. C.; Christensen, P.; Smith, D. E.; Neumann, G. A.; Kirk, R. L.; Caplinger, M. A.; Albee, A. A.; Seregina, N. V.; Neukum, G.; Archinal, B. A.

2014-12-01

The small crater Airy-0 was selected from Mariner 9 images to be the reference for the Mars prime meridian. Initial analyses in the year 2000 tied Viking Orbiter and Mars Orbiter Camera images of Airy-0 to the evolving Mars Orbiter Laser Altimeter global digital terrain model to update the location of Airy-0. Based upon this tie and radiometric tracking of landers/rovers from Earth, new expressions for the Mars spin axis direction, spin rate, and prime meridian epoch value were produced to define the orientation of the Martian surface in inertial space over time. Since the Mars Global Surveyor mission and Mars Orbiter Laser Altimeter global digital terrain model were completed some time ago, a more exhaustive study has been performed to determine the accuracy of the Airy-0 location and orientation of Mars at the standard epoch. Thermal Emission Imaging System (THEMIS) IR image cubes of the Airy and Gale crater regions were tied to the global terrain grid using precision stereo photogrammetric image processing techniques. The Airy-0 location was determined to be about 0.001° east of its predicted location using the currently defined International Astronomical Union (IAU) prime meridian location. Information on this new location and how it was derived will be provided to the NASA Mars Exploration Program Geodesy and Cartography Working Group for their assessment. This NASA group will make a recommendation to the IAU Working Group on Cartographic Coordinates and Rotational Elements to update the expression for the Mars spin axis direction, spin rate, and prime meridian location.

Disordered eating in college sorority women: A social network analysis of a subset of members from a single sorority chapter.

PubMed

Becker, Kendra R; Stojek, Monika M; Clifton, Allan; Miller, Joshua D

2018-06-07

Disordered eating attitudes and behaviors are prevalent among college women, and peers appear to influence current and future eating pathology. Social network analysis (SNA) is an innovative quantitative method to examine relationships (i.e., ties) among people based on their various attributes. In this study, the social network of one sorority was modeled using exponential random graph model (ERGM) to explore if homophily, or the tendency for relationship ties to exist based on shared attributes, was present according to sorority members' disordered eating behaviors/attitudes and their body mass index (BMI). Participants included members of one sorority at a large Southeastern university. All members were included on a roster unless they elected to opt out during the consent process, and 41 (19%) of the members completed the study measures. Participants completed the Social Network Questionnaire developed for this study (degree of "liking" of every member on the roster), the Eating Disorder Examination-Questionnaire (EDE-Q), and a demographics questionnaire in exchange for 1 h of community service credit. The final sample consisted of mostly White women with an average age of 20. Homophily across liking ties was examined based on the EDE-Q Global scale, episodes of binge eating, and BMI. The greater the difference in EDE-Q scores, the more likely the participants were to like one another. The greater the difference in BMI, the less likely the participants were to like one another. Binge eating was unrelated to homophily. College sorority women appear to prefer other women with dissimilar levels of disordered eating attitudes, suggesting complex interactions between stigmatized or valued disordered eating attributes. Women with similar BMI were more likely to like one another, confirming past findings. Copyright © 2018. Published by Elsevier Ltd.

Get Involved in Planetary Discoveries through New Worlds, New Discoveries

NASA Astrophysics Data System (ADS)

Shupla, Christine; Shipp, S. S.; Halligan, E.; Dalton, H.; Boonstra, D.; Buxner, S.; SMD Planetary Forum, NASA

2013-01-01

"New Worlds, New Discoveries" is a synthesis of NASA’s 50-year exploration history which provides an integrated picture of our new understanding of our solar system. As NASA spacecraft head to and arrive at key locations in our solar system, "New Worlds, New Discoveries" provides an integrated picture of our new understanding of the solar system to educators and the general public! The site combines the amazing discoveries of past NASA planetary missions with the most recent findings of ongoing missions, and connects them to the related planetary science topics. "New Worlds, New Discoveries," which includes the "Year of the Solar System" and the ongoing celebration of the "50 Years of Exploration," includes 20 topics that share thematic solar system educational resources and activities, tied to the national science standards. This online site and ongoing event offers numerous opportunities for the science community - including researchers and education and public outreach professionals - to raise awareness, build excitement, and make connections with educators, students, and the public about planetary science. Visitors to the site will find valuable hands-on science activities, resources and educational materials, as well as the latest news, to engage audiences in planetary science topics and their related mission discoveries. The topics are tied to the big questions of planetary science: how did the Sun’s family of planets and bodies originate and how have they evolved? How did life begin and evolve on Earth, and has it evolved elsewhere in our solar system? Scientists and educators are encouraged to get involved either directly or by sharing "New Worlds, New Discoveries" and its resources with educators, by conducting presentations and events, sharing their resources and events to add to the site, and adding their own public events to the site’s event calendar! Visit to find quality resources and ideas. Connect with educators, students and the public to share the exciting planetary science discoveries as they’re uncovered during this unprecedented period of solar system exploration!

Social Identity, Social Ties and Social Capital: A Study in Gaming Context

ERIC Educational Resources Information Center

Jiang, Hao

2012-01-01

This work will focus on how different social relationships, namely shared identity and personal tie, will impact cooperative behavior, a form of social capital. I designed and conducted an economic game study to show that shared identity and personal ties work differently on cooperation among people and resource flow in social groups. Many factors…

Effects of a Group Intervention on the Career Network Ties of Finnish Adolescents

ERIC Educational Resources Information Center

Jokisaari, Markku; Vuori, Jukka

2011-01-01

The authors evaluated how a group-based career intervention affected career network ties among Finnish adolescents as they made educational choices and prepared for their transition to secondary education. They examined the career-related network ties of 868 students during their last year in comprehensive school (junior high school) in a…

Polycyclic aromatic hydrocarbon migration from creosote-treated railway ties into ballast and adjacent wetlands

Treesearch

Kenneth M. Brooks

2004-01-01

Occasionally, creosote-treated railroad ties need to be replaced, sometimes in sensitive environments such as wetlands. To help determine if this is detrimental to the surrounding environment, more information is needed on the extent and pattern of creosote, or more specifically polycyclic aromatic hydrocarbon (PAH), migration from railroad ties and what effects this...

78 FR 25303 - Prestressed Concrete Steel Rail Tie Wire From China, Mexico, and Thailand

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-30

... Concrete Steel Rail Tie Wire From China, Mexico, and Thailand Institution of antidumping duty..., by reason of imports from prestressed concrete steel rail tie wire from China, Mexico, and Thailand... filed on April 23, 2013, by Davis Wire Corp. of Kent, WA and Insteel Wire Product Co. of Mount Airy, NC...

78 FR 37236 - Prestressed Concrete Steel Rail Tie Wire From China, Mexico, and Thailand

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-20

... Concrete Steel Rail Tie Wire From China, Mexico, and Thailand Determinations On the basis of the record \\1... imports from China, Mexico, and Thailand of prestressed concrete steel rail tie wire, provided for in... petition was filed with the Commission and Commerce by Davis Wire Corp. of Kent, WA and Insteel Wire...

78 FR 75547 - Prestressed Concrete Steel Rail Tie Wire From Thailand: Preliminary Determination of Sales at Not...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-12

... Rail Tie Wire From Thailand: Preliminary Determination of Sales at Not Less Than Fair Value and...'') preliminarily determines that prestressed concrete steel rail tire wire (``PC tie wire'') from Thailand is not... Investigation The product covered by this investigation is high carbon steel wire; stress relieved or low...

78 FR 29325 - Prestressed Concrete Steel Rail Tie Wire From Mexico, the People's Republic of China, and...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-20

...] Prestressed Concrete Steel Rail Tie Wire From Mexico, the People's Republic of China, and Thailand: Initiation... (Mexico), Brian Smith (the People's Republic of China (the ``PRC'')), or Kate Johnson (Thailand) at (202... Prestressed Concrete Steel Rail Tie Wire from the People's Republic of China, Mexico, and Thailand...

75 FR 34941 - Review of the Commission's Program Access Rules and Examination of Programming Tying Arrangements

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-21

... Commission's Program Access Rules and Examination of Programming Tying Arrangements AGENCY: Federal... Program Access Rules and Examination of Programming Tying Arrangements, MB Docket No. 07-198, FCC 10-17... information collection is contained in Sections 4(i), 303(r), and 628 of the Communications Act of 1934, as...

PREECLAMPSIA AND SMALL FOR GESTATIONAL AGE ARE ASSOCIATED WITH DECREASED CONCENTRATIONS OF A FACTOR INVOLVED IN ANGIOGENESIS: SOLUBLE TIE-2

PubMed Central

Gotsch, Francesca; Romero, Roberto; Kusanovic, Juan Pedro; Chaiworapongsa, Tinnakorn; Dombrowski, Michael; Erez, Offer; Than, Nandor Gabor; Mazaki-Tovi, Shali; Mittal, Pooja; Espinoza, Jimmy; Hassan, Sonia S

2009-01-01

OBJECTIVE An anti-angiogenic state has been described in patients with preeclampsia, small for gestational age (SGA) fetuses and fetal death, and changes in the concentration of circulating angiogenic and anti-angiogenic factors can precede the clinical recognition of preeclampsia and small for gestational age by several weeks. Gene deletion studies demonstrate that a selective group of endothelial growth factors are required for vascular development, including members of the vascular endothelial growth factor (VEGF) family, as well as Angiopoietin-1 and Angiopoietin-2, both ligands for the tyrosine kinase endothelial cell receptor Tie-2. These angiogenic factors have been proposed to promote angiogenesis in a coordinated and complementary fashion. Soluble Tie-2 (sTie-2) is the soluble form of the Tie-2 receptor which is detectable in biological fluids. The purpose of this study was to determine whether patients with preeclampsia and mothers who deliver a small for gestational age neonate have changes in the plasma concentrations of sTie-2. STUDY DESIGN This cross-sectional study included patients in the following groups: 1) non-pregnant women (n=40); 2) women with normal pregnancies (n=135); 3) patients with preeclampsia (n=112); and 4) patients who delivered a small for gestational age (SGA) neonate (n=53). Maternal plasma concentrations of sTie-2 were measured by a sensitive immunoassay. Parametric statistics were used for analysis. RESULTS 1) The median maternal plasma concentration of sTie-2 was lower in normal pregnant women than in non-pregnant women [median 16.0 ng/ml (range 5.0–71.6) vs. median 20.7 ng/ml (range 10.8–52.4), respectively; p=0.01)]; 2) Plasma sTie-2 concentrations in normal pregnancy changed significantly as a function of gestational age; 3) Patients with preeclampsia and those who delivered SGA neonates had a lower median maternal plasma concentration of sTie-2 than those with a normal pregnancy [Preeclampsia: median 14.9 ng/ml (range 4.9–67.3); SGA: median 10.9 ng/ml (range 5.1–29.1); Normal pregnancy: median 16.0 ng/ml (range 5.0–71.6); p=0.048 and p<0.001, respectively]; 4) Patients with SGA neonates had a lower median plasma concentration of sTie-2 than that of those with preeclampsia [median 10.9 ng/ml (range 5.1–29.1) vs. median 14.9 ng/ml (range 4.9–67.3), respectively; p<0.001)]; and 5) Patients with early-onset preeclampsia (≤34 weeks) had lower concentrations of sTie-2 than women with late-onset preeclampsia (>34 weeks) [median of delta values: −0.13 ng/ml (range −0.47–0.58) vs. median of delta values: −0.09 ng/ml (range: −0.60–0.58), respectively; p=0.043]. In contrast, there were no significant differences in the maternal plasma sTie-2 concentration between women with severe and mild preeclampsia (p=0.6). CONCLUSION Patients with preeclampsia and those with SGA fetuses have lower median plasma concentrations of soluble Tie-2 than women with normal pregnancies. PMID:18570117

Tie2 Expressing Monocytes in the Spleen of Patients with Primary Myelofibrosis

PubMed Central

Campanelli, Rita; Fois, Gabriela; Catarsi, Paolo; Poletto, Valentina; Villani, Laura; Erba, Benedetta Gaia; Maddaluno, Luigi; Jemos, Basilio; Salmoiraghi, Silvia; Guglielmelli, Paola; Abbonante, Vittorio; Di Buduo, Christian Andrea; Balduini, Alessandra; Iurlo, Alessandra; Barosi, Giovanni; Rosti, Vittorio; Massa, Margherita

2016-01-01

Primary myelofibrosis (PMF) is a Philadelphia-negative (Ph−) myeloproliferative disorder, showing abnormal CD34+ progenitor cell trafficking, splenomegaly, marrow fibrosis leading to extensive extramedullary haematopoiesis, and abnormal neoangiogenesis in either the bone marrow or the spleen. Monocytes expressing the angiopoietin-2 receptor (Tie2) have been shown to support abnormal angiogenic processes in solid tumors through a paracrine action that takes place in proximity to the vessels. In this study we investigated the frequency of Tie2 expressing monocytes in the spleen tissue samples of patients with PMF, and healthy subjects (CTRLs), and evaluated their possible role in favouring spleen angiogenesis. We show by confocal microscopy that in the spleen tissue of patients with PMF, but not of CTRLs, the most of the CD14+ cells are Tie2+ and are close to vessels; by flow cytometry, we found that Tie2 expressing monocytes were Tie2+CD14lowCD16brightCDL62−CCR2− (TEMs) and their frequency was higher (p = 0.008) in spleen tissue-derived mononuclear cells (MNCs) of patients with PMF than in spleen tissue-derived MNCs from CTRLs undergoing splenectomy for abdominal trauma. By in vitro angiogenesis assay we evidenced that conditioned medium of immunomagnetically selected spleen tissue derived CD14+ cells of patients with PMF induced a denser tube like net than that of CTRLs; in addition, CD14+Tie2+ cells sorted from spleen tissue derived single cell suspension of patients with PMF show a higher expression of genes involved in angiogenesis than that found in CTRLs. Our results document the enrichment of Tie2+ monocytes expressing angiogenic genes in the spleen of patients with PMF, suggesting a role for these cells in starting/maintaining the pathological angiogenesis in this organ. PMID:27281335

Combined Gene Therapy Using AdsVEGFR2 and AdsTie2 With Chemotherapy Reduces the Growth of Human Ovarian Cancer and Formation of Ascites in Mice.

PubMed

Tuppurainen, Laura; Sallinen, Hanna; Karvonen, Anni; Valkonen, Elina; Laakso, Hanne; Liimatainen, Timo; Hytönen, Elisa; Hämäläinen, Kirsi; Kosma, Veli-Matti; Anttila, Maarit; Ylä-Herttuala, Seppo

2017-06-01

Ovarian cancer is highly dependent on tumor microvessels and angiogenesis regulated by vascular endothelial growth factors (VEGFs) and their receptors (VEGFRs) and angiopoietins (Ang) and their Tie receptors. We studied the efficacy of adenoviral (Ad) gene therapy with soluble VEGFR2 and Tie2 combined with paclitaxel and carboplatin for the treatment of ovarian cancer. An intraperitoneal human ovarian cancer xenograft model in nude mice (n = 44) was used in this study. Gene therapy was given intravenously when the presence of sizable tumors was confirmed in magnetic resonance imaging. The study groups were as follows: AdCMV as a control (group I), AdCMV with chemotherapy (group II), AdsVEGFR2 and AdsTie2 (group III), and AdsVEGFR2 and AdsTie2 with chemotherapy (group IV). Antitumor effectiveness was assessed by overall tumor growth, ascites, immunohistochemistry, microvessel density, and sequential magnetic resonance imaging analyses. AdsVEGFR2 and AdsTie2 gene therapy (group III) significantly reduced tumor weights as compared with group II (P = 0.007). Accumulation of ascites was significantly reduced when the mice were treated with AdsVEGFR2 and AdsTie2 gene therapy or with combined gene therapy and chemotherapy as compared with controls (P = 0.029 and P = 0.010, respectively). Vascular endothelial growth factor and Ang2 levels in ascites fluid were elevated after the gene therapy. Combined inhibition of VEGF/VEGFR2 and Ang/Tie2 pathways provided efficient therapy for ovarian cancer in mice. In addition, antiangiogenic gene therapy has potential as a treatment for the accumulation of ascites.

Affect asymmetry and comfort food consumption.

PubMed

Dubé, Laurette; LeBel, Jordan L; Lu, Ji

2005-11-15

It is proposed that the emotional triggers of comfort food consumption can reliably be predicted by factors tied to affect asymmetry whereby negative affects dominate one's experience, decision making and behaviors in some instances while positive emotions prevail in others. Specifically, we relate three of these factors (age, gender, and culture) to differences in the emotional triggers of comfort food consumption and we further explore the possibility that the type of food eaten during comfort-seeking episodes can also be tied to affect asymmetry. Two hundred and seventy-seven participants completed a web-based survey conducted to assess the emotional antecedents and consequences of comfort food consumption. Consistent with expectations, results indicate that men's comfort food consumption was motivated by positive emotions whereas women's consumption was triggered by negative affects. Consumption of comfort foods alleviated women's negative emotions but also produced guilt. Positive affect was a particularly powerful trigger of comfort food consumption for older participants and for participants with French cultural background. Younger participants and participants with English background reported more intense negative emotions prior to consuming comfort foods. Foods high in sugar and fat content were more efficient in alleviating negative affects whereas low-calorie foods were more efficient in increasing positive emotions.

The promotion of unhealthy habits in gay, lesbian, and straight intimate partnerships

PubMed Central

Reczek, Corinne

2016-01-01

Health habits are linked to nearly half of U.S. and British deaths annually. While a legacy of research suggests that marriage has important positive consequences for health habits, recent work emphasizes that intimate ties can also deter from healthy habits and promote unhealthy habits. However, few studies examine the mechanisms through which unhealthy habits are promoted in marriage. Moreover, little research explores how unhealthy habits are promoted in intimate ties other than marriage—such as in gay and lesbian cohabiting relationships. The present study analyzes the mechanisms through which gay, lesbian, and straight long-term partners (N = 120) contribute to one another’s unhealthy habits. Three distinct mechanisms emerge. First, respondents identify a process of unilateral health habit diffusion wherein one partner’s health habits directly influence the other partners’ habits. Second, respondents describe bilateral unhealthy habit diffusion, wherein both partner’s unhealthy habits are reinforced via mutual pleasure seeking or mutual failed motivation. Third, respondents describe a discourse of personal responsibility, wherein both partners purposefully fail to deter one another’s unhealthy habits. Analysis further illustrates how these mechanisms operate differently for men and women in gay, lesbian, and straight relationships. PMID:22703888

Exploration of the strength of family links

NASA Astrophysics Data System (ADS)

Richmond, Peter; Roehner, Bertrand M.

2018-07-01

Ever since the studies of Louis-Adolphe Bertillon in the late 19th century it has been known that marital status and number of children markedly affect death and suicide rates. This led in 1898 Emile Durkheim to conjecture a connection between social isolation (especially at family level) and suicide. However, further progress was long hampered by the limited statistical data available from death certificates. Recently, it was shown by the present authors that disability data from census records can be used as a reliable substitute for mortality data. This opens a new route to investigations of family ties because census information goes much beyond the limited data reported on death certificates. It is shown that the disability rate of adults decreases when they have more family links. More precisely, the reduction of the parents' disability brought about by the presence of a child reveals that the strength of ties between parents and child is highest in the first year after birth and then weakens steadily as the child ages. It will also be seen that the strength of the bond between husband and wife is highest when they are of same age and decreases fairly steadily when the age gap increases.

Music as Illness; Music as Healing.

PubMed

Pritchard, Maureen

2015-09-01

Throughout the Soviet Union, the arts became tied to ethnicity through the project of Socialist Realism. When, in 1991, the Kyrgyz Republic became independent from the Soviet Union, its national narrative continued to be built upon tropes of Kyrgyz ethnicity. Through their engagement with images of the ethno-national self, the arts provide a great source of beauty. Defining beauty as a representation of the self that is pure whole, and stable, Julia Kristeva asserts that beauty and suffering are part of the same phenomena. Arthur Kleinman argues that suffering is best understood as existing within the triangulated relationship of cultural representation, collective experience, and subjectivity. Music too is part of this triangulated relationship, and therefore, a part of suffering. Drawing upon ten months of ethnographic fieldwork in Kyrgyzstan, this article explores the illness experience of a single Kyrgyz musician. In doing so, it illustrates music's role in self-formation and the development of social, economic, and political ties and the shifts that occur in these during illness. In drawing forth the role of music in the construction of racialized ethnicities, this article demonstrates how the experience of transformative beauty can coexist with turmoil, marginalization, and violence.

The promotion of unhealthy habits in gay, lesbian, and straight intimate partnerships.

PubMed

Reczek, Corinne

2012-09-01

Health habits are linked to nearly half of U.S. and British deaths annually. While a legacy of research suggests that marriage has important positive consequences for health habits, recent work emphasizes that intimate ties can also deter from healthy habits and promote unhealthy habits. However, few studies examine the mechanisms through which unhealthy habits are promoted in marriage. Moreover, little research explores how unhealthy habits are promoted in intimate ties other than marriage-such as in gay and lesbian cohabiting relationships. The present study analyzes the mechanisms through which gay, lesbian, and straight long-term partners (N = 120) contribute to one another's unhealthy habits. Three distinct mechanisms emerge. First, respondents identify a process of unilateral health habit diffusion wherein one partner's health habits directly influence the other partners' habits. Second, respondents describe bilateral unhealthy habit diffusion, wherein both partner's unhealthy habits are reinforced via mutual pleasure seeking or mutual failed motivation. Third, respondents describe a discourse of personal responsibility, wherein both partners purposefully fail to deter one another's unhealthy habits. Analysis further illustrates how these mechanisms operate differently for men and women in gay, lesbian, and straight relationships. Copyright © 2012 Elsevier Ltd. All rights reserved.

Reporting Science and Conflicts of Interest in the Lay Press

PubMed Central

Cook, Daniel M.; Boyd, Elizabeth A.; Grossmann, Claudia; Bero, Lisa A.

2007-01-01

Background Forthright reporting of financial ties and conflicts of interest of researchers is associated with public trust in and esteem for the scientific enterprise. Methods/Principal Findings We searched Lexis/Nexis Academic News for the top news stories in science published in 2004 and 2005. We conducted a content analysis of 1152 newspaper stories. Funders of the research were identified in 38% of stories, financial ties of the researchers were reported in 11% of stories, and 5% reported financial ties of sources quoted. Of 73 stories not reporting on financial ties, 27% had financial ties publicly disclosed in scholarly journals. Conclusions/Significance Because science journalists often did not report conflict of interest information, adherence to gold-standard recommendations for science journalism was low. Journalists work under many different constraints, but nonetheless news reports of scientific research were incomplete, potentially eroding public trust in science. PMID:18060060

Quality versus quantity of social ties in experimental cooperative networks.

PubMed

Shirado, Hirokazu; Fu, Feng; Fowler, James H; Christakis, Nicholas A

2013-01-01

Recent studies suggest that allowing individuals to choose their partners can help to maintain cooperation in human social networks; this behaviour can supplement behavioural reciprocity, whereby humans are influenced to cooperate by peer pressure. However, it is unknown how the rate of forming and breaking social ties affects our capacity to cooperate. Here we use a series of online experiments involving 1,529 unique participants embedded in 90 experimental networks, to show that there is a 'Goldilocks' effect of network dynamism on cooperation. When the rate of change in social ties is too low, subjects choose to have many ties, even if they attach to defectors. When the rate is too high, cooperators cannot detach from defectors as much as defectors re-attach and, hence, subjects resort to behavioural reciprocity and switch their behaviour to defection. Optimal levels of cooperation are achieved at intermediate levels of change in social ties.

Tie2 and Eph Receptor Tyrosine Kinase Activation and Signaling

PubMed Central

Barton, William A.; Dalton, Annamarie C.; Seegar, Tom C.M.; Himanen, Juha P.

2014-01-01

The Eph and Tie cell surface receptors mediate a variety of signaling events during development and in the adult organism. As other receptor tyrosine kinases, they are activated on binding of extracellular ligands and their catalytic activity is tightly regulated on multiple levels. The Eph and Tie receptors display some unique characteristics, including the requirement of ligand-induced receptor clustering for efficient signaling. Interestingly, both Ephs and Ties can mediate different, even opposite, biological effects depending on the specific ligand eliciting the response and on the cellular context. Here we discuss the structural features of these receptors, their interactions with various ligands, as well as functional implications for downstream signaling initiation. The Eph/ephrin structures are already well reviewed and we only provide a brief overview on the initial binding events. We go into more detail discussing the Tie-angiopoietin structures and recognition. PMID:24478383

Mapping Engagement in Twitter-Based Support Networks for Adult Smoking Cessation

PubMed Central

Pechmann, Cornelia; Wang, Cheng; Pan, Li; Delucchi, Kevin; Prochaska, Judith J.

2016-01-01

We examined engagement in novel quit-smoking private social support networks on Twitter, January 2012 to April 2014. We mapped communication patterns within 8 networks of adult smokers (n = 160) with network ties defined by participants’ tweets over 3 time intervals, and examined tie reciprocity, tie strength, in-degree centrality (popularity), 3-person triangles, 4-person cliques, network density, and abstinence status. On average, more than 50% of ties were reciprocated in most networks and most ties were between abstainers and nonabstainers. Tweets formed into more aggregated patterns especially early in the study. Across networks, 35.00% (7 days after the quit date), 49.38% (30 days), and 46.88% (60 days) abstained from smoking. We demonstrated that abstainers and nonabstainers engaged with one another in dyads and small groups. This study preliminarily suggests potential for Twitter as a platform for adult smoking-cessation interventions. PMID:27310342

Self-renewal of a purified Tie2+ hematopoietic stem cell population relies on mitochondrial clearance.

PubMed

Ito, Kyoko; Turcotte, Raphaël; Cui, Jinhua; Zimmerman, Samuel E; Pinho, Sandra; Mizoguchi, Toshihide; Arai, Fumio; Runnels, Judith M; Alt, Clemens; Teruya-Feldstein, Julie; Mar, Jessica C; Singh, Rajat; Suda, Toshio; Lin, Charles P; Frenette, Paul S; Ito, Keisuke

2016-12-02

A single hematopoietic stem cell (HSC) is capable of reconstituting hematopoiesis and maintaining homeostasis by balancing self-renewal and cell differentiation. The mechanisms of HSC division balance, however, are not yet defined. Here we demonstrate, by characterizing at the single-cell level a purified and minimally heterogeneous murine Tie2 + HSC population, that these top hierarchical HSCs preferentially undergo symmetric divisions. The induction of mitophagy, a quality control process in mitochondria, plays an essential role in self-renewing expansion of Tie2 + HSCs. Activation of the PPAR (peroxisome proliferator-activated receptor)-fatty acid oxidation pathway promotes expansion of Tie2 + HSCs through enhanced Parkin recruitment in mitochondria. These metabolic pathways are conserved in human TIE2 + HSCs. Our data thus identify mitophagy as a key mechanism of HSC expansion and suggest potential methods of cell-fate manipulation through metabolic pathways. Copyright © 2016, American Association for the Advancement of Science.

Self-renewal of a purified Tie2+ hematopoietic stem cell population relies on mitochondrial clearance

PubMed Central

Ito, Kyoko; Turcotte, Raphaël; Cui, Jinhua; Zimmerman, Samuel E.; Pinho, Sandra; Mizoguchi, Toshihide; Arai, Fumio; Runnels, Judith M.; Alt, Clemens; Teruya-Feldstein, Julie; Mar, Jessica C.; Singh, Rajat; Suda, Toshio; Lin, Charles P.; Frenette, Paul S.; Ito, Keisuke

2016-01-01

A single hematopoietic stem cell (HSC) is capable of reconstituting hematopoiesis and maintaining homeostasis by balancing self-renewal and cell differentiation. The mechanisms of HSC division balance, however, are not yet defined. Here we demonstrate, by characterizing at the single-cell level a purified and minimally heterogeneous murine Tie2+ HSC population, that these top hierarchical HSCs preferentially undergo symmetric divisions. The induction of mitophagy, a quality control process in mitochondria, plays an essential role in self-renewing expansion of Tie2+ HSCs. Activation of the PPAR (peroxisome proliferator–activated receptor)–fatty acid oxidation pathway promotes expansion of Tie2+ HSCs through enhanced Parkin recruitment in mitochondria. These metabolic pathways are conserved in human TIE2+ HSCs. Our data thus identify mitophagy as a key mechanism of HSC expansion and suggest potential methods of cell-fate manipulation through metabolic pathways. PMID:27738012

Quality versus quantity of social ties in experimental cooperative networks

PubMed Central

Shirado, Hirokazu; Fu, Feng; Fowler, James H.; Christakis, Nicholas A.

2013-01-01

Recent studies suggest that allowing individuals to choose their partners can help to maintain cooperation in human social networks; this behaviour can supplement behavioural reciprocity, whereby humans are influenced to cooperate by peer pressure. However, it is unknown how the rate of forming and breaking social ties affects our capacity to cooperate. Here we use a series of online experiments involving 1,529 unique participants embedded in 90 experimental networks, to show that there is a ‘Goldilocks’ effect of network dynamism on cooperation. When the rate of change in social ties is too low, subjects choose to have many ties, even if they attach to defectors. When the rate is too high, cooperators cannot detach from defectors as much as defectors re-attach and, hence, subjects resort to behavioural reciprocity and switch their behaviour to defection. Optimal levels of cooperation are achieved at intermediate levels of change in social ties. PMID:24226079

Mapping Engagement in Twitter-Based Support Networks for Adult Smoking Cessation.

PubMed

Lakon, Cynthia M; Pechmann, Cornelia; Wang, Cheng; Pan, Li; Delucchi, Kevin; Prochaska, Judith J

2016-08-01

We examined engagement in novel quit-smoking private social support networks on Twitter, January 2012 to April 2014. We mapped communication patterns within 8 networks of adult smokers (n = 160) with network ties defined by participants' tweets over 3 time intervals, and examined tie reciprocity, tie strength, in-degree centrality (popularity), 3-person triangles, 4-person cliques, network density, and abstinence status. On average, more than 50% of ties were reciprocated in most networks and most ties were between abstainers and nonabstainers. Tweets formed into more aggregated patterns especially early in the study. Across networks, 35.00% (7 days after the quit date), 49.38% (30 days), and 46.88% (60 days) abstained from smoking. We demonstrated that abstainers and nonabstainers engaged with one another in dyads and small groups. This study preliminarily suggests potential for Twitter as a platform for adult smoking-cessation interventions.

Nuclear Thermal Rocket - Arc Jet Integrated System Model

NASA Technical Reports Server (NTRS)

Taylor, Brian D.; Emrich, William

2016-01-01

In the post-shuttle era, space exploration is moving into a new regime. Commercial space flight is in development and is planned to take on much of the low earth orbit space flight missions. With the development of a heavy lift launch vehicle, the Space Launch, System, NASA has become focused on deep space exploration. Exploration into deep space has traditionally been done with robotic probes. More ambitious missions such as manned missions to asteroids and Mars will require significant technology development. Propulsion system performance is tied to the achievability of these missions and the requirements of other developing technologies that will be required. Nuclear thermal propulsion offers a significant improvement over chemical propulsion while still achieving high levels of thrust. Opportunities exist; however, to build upon what would be considered a standard nuclear thermal engine to attain improved performance, thus further enabling deep space missions. This paper discuss the modeling of a nuclear thermal system integrated with an arc jet to further augment performance. The performance predictions and systems impacts are discussed.