75 FR 33682 - Export Administration Regulations; Technical Amendments

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-15

...-01] RIN 0694-AE93 Export Administration Regulations; Technical Amendments AGENCY: Bureau of Industry... Bureau of Industry and Security (BIS) makes a technical amendment to the Export Administration... review of final decisions and orders issued in BIS export control administrative enforcement proceedings...

78 FR 54623 - Effects of Foreign Policy-Based Export Controls

Federal Register 2010, 2011, 2012, 2013, 2014

2013-09-05

... Foreign Policy-Based Export Controls AGENCY: Bureau of Industry and Security, Commerce. ACTION: Request... export controls in the Export Administration Regulations. BIS is requesting public comments to conduct... with industry on the effect of such controls and to report the results of the consultations to Congress...

48 CFR 204.7302 - General.

Code of Federal Regulations, 2011 CFR

2011-10-01

... DEFENSE GENERAL ADMINISTRATIVE MATTERS Export-Controlled Items 204.7302 General. Certain types of items are subject to export controls in accordance with the Arms Export Control Act (22 U.S.C. 2751, et seq.), the International Traffic in Arms Regulations (22 CFR parts 120-130), the Export Administration Act of...

48 CFR 204.7302 - General.

Code of Federal Regulations, 2010 CFR

2010-10-01

... DEFENSE GENERAL ADMINISTRATIVE MATTERS Export-Controlled Items 204.7302 General. Certain types of items are subject to export controls in accordance with the Arms Export Control Act (22 U.S.C. 2751, et seq.), the International Traffic in Arms Regulations (22 CFR parts 120-130), the Export Administration Act of...

77 FR 37523 - Proposed Revisions to the Export Administration Regulations: Implementation of Export Control...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-21

... manufacturers to design out and avoid U.S.-origin content and services, and (iii) allowing export control... they are ``dual- use'' items. The CCL controls ``dual use'' (e.g., items designed for both military and...: Implementation of Export Control Reform; Revisions to License Exceptions After Retrospective Regulatory Review...

31 CFR 592.201 - Prohibited importation and exportation of any rough diamond; permitted importation or exportation...

Code of Federal Regulations, 2011 CFR

2011-07-01

... of any rough diamond; permitted importation or exportation of any rough diamond. 592.201 Section 592... FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY ROUGH DIAMONDS CONTROL REGULATIONS Prohibitions § 592.201 Prohibited importation and exportation of any rough diamond; permitted importation or exportation...

31 CFR 592.201 - Prohibited importation and exportation of any rough diamond; permitted importation or exportation...

Code of Federal Regulations, 2012 CFR

2012-07-01

... of any rough diamond; permitted importation or exportation of any rough diamond. 592.201 Section 592... FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY ROUGH DIAMONDS CONTROL REGULATIONS Prohibitions § 592.201 Prohibited importation and exportation of any rough diamond; permitted importation or exportation...

31 CFR 592.201 - Prohibited importation and exportation of any rough diamond; permitted importation or exportation...

Code of Federal Regulations, 2013 CFR

2013-07-01

... of any rough diamond; permitted importation or exportation of any rough diamond. 592.201 Section 592... FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY ROUGH DIAMONDS CONTROL REGULATIONS Prohibitions § 592.201 Prohibited importation and exportation of any rough diamond; permitted importation or exportation...

31 CFR 592.201 - Prohibited importation and exportation of any rough diamond; permitted importation or exportation...

Code of Federal Regulations, 2014 CFR

2014-07-01

... of any rough diamond; permitted importation or exportation of any rough diamond. 592.201 Section 592... FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY ROUGH DIAMONDS CONTROL REGULATIONS Prohibitions § 592.201 Prohibited importation and exportation of any rough diamond; permitted importation or exportation...

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hagen, Gary D.

Export Control Reform has been in motion for six years. In 2014, the ITAR regulations surrendered export control of nuclear weapons technology to the control of DOE. Yet no Federal Register notice by DOE detailed where those new regulations could be found. This article explains the disposition that occurred.

21 CFR 1312.23 - Issuance of export permit.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 21 Food and Drugs 9 2010-04-01 2010-04-01 false Issuance of export permit. 1312.23 Section 1312.23... CONTROLLED SUBSTANCES Exportation of Controlled Substances § 1312.23 Issuance of export permit. (a) The... regulation in § 1312.30 of this part be exported only pursuant to the issuance of an export permit. The...

31 CFR 538.507 - Reexports by non-U.S. persons.

Code of Federal Regulations, 2010 CFR

2010-07-01

...) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY SUDANESE SANCTIONS REGULATIONS Licenses... technology subject to export license application requirements under other United States regulations. The... the United States, the exportation of which to Sudan is subject to export or reexport license...

JPL Export Compliance Program

NASA Technical Reports Server (NTRS)

Momjian, E.; Lam, C.

2000-01-01

The transfer of commodities, software, or technlogies to foreign persons is subject to U.S. export control laws and regulations. These export controls are applicable, regardless of whether the transfer occurs in the U.S. or outside of the U.S.

76 FR 41046 - Addition of the New State of the Republic of South Sudan to the Export Administration Regulations

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-13

... Administration Regulations AGENCY: Bureau of Industry and Security, Commerce. ACTION: Final rule. SUMMARY: In this final rule, the Bureau of Industry and Security (BIS) amends the Export Administration Regulations (EAR) to add controls on exports and reexports of U.S.-origin dual-use items to a new nation, the...

48 CFR 204.7301 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 48 Federal Acquisition Regulations System 3 2012-10-01 2012-10-01 false Definitions. 204.7301 Section 204.7301 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE GENERAL ADMINISTRATIVE MATTERS Export-Controlled Items 204.7301 Definitions. Export...

48 CFR 204.7301 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Definitions. 204.7301 Section 204.7301 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE GENERAL ADMINISTRATIVE MATTERS Export-Controlled Items 204.7301 Definitions. Export...

48 CFR 204.7301 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 48 Federal Acquisition Regulations System 3 2011-10-01 2011-10-01 false Definitions. 204.7301 Section 204.7301 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE GENERAL ADMINISTRATIVE MATTERS Export-Controlled Items 204.7301 Definitions. Export...

77 FR 25932 - Revisions to the Export Administration Regulations (EAR): Control of Energetic Materials and...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-02

... the fact that they apply to the same group of destinations as missile technology controls (i.e., both... Requirements section of ECCN 1E101, consistent with the ``technology'' controls of the Nuclear Suppliers Group.... 120105018-2011-01] RIN 0694-AF53 Revisions to the Export Administration Regulations (EAR): Control of...

78 FR 43849 - Submission for OMB Review; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-22

...: Export Fruit Regulations. OMB Control Number: 0581-0143. Summary of Collection: Fresh apples and grapes... requirements established by regulations issued under the Export Apple Act (7 CFR Part 33) and the Export Grape... States in apples and grapes; to protect the reputation of these American-grown commodities; and to...

75 FR 50679 - Continuation of Emergency Regarding Export Control Regulations

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-16

... Part III The President Notice of August 12, 2010--Continuation of Emergency Regarding Export Control Regulations #0; #0; #0; Presidential Documents #0; #0; #0;#0;Federal Register / Vol. 75, No. 157 / Monday, August 16, 2010 / Presidential Documents#0;#0; #0; #0;Title 3-- #0;The President [[Page 50681...

31 CFR 592.304 - Exporting authority.

Code of Federal Regulations, 2014 CFR

2014-07-01

... FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY ROUGH DIAMONDS CONTROL REGULATIONS General Definitions... a Participant from whose territory a shipment of rough diamonds is being exported as having the...

31 CFR 592.304 - Exporting authority.

Code of Federal Regulations, 2011 CFR

2011-07-01

... FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY ROUGH DIAMONDS CONTROL REGULATIONS General Definitions... a Participant from whose territory a shipment of rough diamonds is being exported as having the...

31 CFR 592.304 - Exporting authority.

Code of Federal Regulations, 2013 CFR

2013-07-01

... FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY ROUGH DIAMONDS CONTROL REGULATIONS General Definitions... a Participant from whose territory a shipment of rough diamonds is being exported as having the...

31 CFR 592.304 - Exporting authority.

Code of Federal Regulations, 2012 CFR

2012-07-01

... FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY ROUGH DIAMONDS CONTROL REGULATIONS General Definitions... a Participant from whose territory a shipment of rough diamonds is being exported as having the...

32 CFR 250.9 - Notice to accompany the dissemination of export-controlled technical data.

Code of Federal Regulations, 2011 CFR

2011-07-01

... Commerce for items controlled by the Export Administration Regulations (EAR), may constitute a violation of..., the penalty for unlawful export of items or information controlled under the EAR is a fine of up to $1... resulting from manufacture or use for any purpose of any product, article, system, or material involving...

32 CFR 250.9 - Notice to accompany the dissemination of export-controlled technical data.

Code of Federal Regulations, 2012 CFR

2012-07-01

... Commerce for items controlled by the Export Administration Regulations (EAR), may constitute a violation of..., the penalty for unlawful export of items or information controlled under the EAR is a fine of up to $1... resulting from manufacture or use for any purpose of any product, article, system, or material involving...

32 CFR 250.9 - Notice to accompany the dissemination of export-controlled technical data.

Code of Federal Regulations, 2013 CFR

2013-07-01

... Commerce for items controlled by the Export Administration Regulations (EAR), may constitute a violation of..., the penalty for unlawful export of items or information controlled under the EAR is a fine of up to $1... resulting from manufacture or use for any purpose of any product, article, system, or material involving...

32 CFR 250.9 - Notice to accompany the dissemination of export-controlled technical data.

Code of Federal Regulations, 2014 CFR

2014-07-01

... Commerce for items controlled by the Export Administration Regulations (EAR), may constitute a violation of..., the penalty for unlawful export of items or information controlled under the EAR is a fine of up to $1... resulting from manufacture or use for any purpose of any product, article, system, or material involving...

77 FR 72917 - Editorial Corrections to the Commerce Control List of the Export Administration Regulations

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-07

... DEPARTMENT OF COMMERCE Bureau of Industry and Security 15 CFR Part 774 [Docket No. 120320200-2296-01] RIN 0694-AF62 Editorial Corrections to the Commerce Control List of the Export Administration Regulations AGENCY: Bureau of Industry and Security, Commerce. ACTION: Final rule. SUMMARY: This final rule...

15 CFR 742.17 - Exports of firearms to OAS member countries.

Code of Federal Regulations, 2010 CFR

2010-01-01

... REGULATIONS CONTROL POLICY-CCL BASED CONTROLS § 742.17 Exports of firearms to OAS member countries. (a... not entered into force. (b) Licensing policy. Applications supported by an Import Certificate or... be approved, except there is a policy of denial for applications to export items linked to such...

78 FR 70916 - Regulations and Procedures Technical Advisory Committee; Notice of Partially Closed Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2013-11-27

... Session 1. Opening remarks by the Chairman. 2. Opening remarks by Bureau of Industry and Security. 3. Export Enforcement update. 4. Regulations update. 5. Update on Export Control Reform Training for Customs...

Global Research in an Age of Export Controls

ERIC Educational Resources Information Center

Monastersky, Richard

2008-01-01

When a jury convicted a Tennessee professor this month of illegally exporting information to foreign countries via his graduate students and a trip to China, it sent a message to colleges that they need to scrupulously monitor their faculty members' research and their compliance with the often confusing universe of export-control regulations. In…

78 FR 35195 - Acquisition Regulations: Export Control

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-12

... Control AGENCY: Department of Energy. ACTION: Notice of proposed rulemaking. SUMMARY: The Department of... control requirements applicable to the performance of DOE contracts. DATES: Written comments on this... comments, identified by ``DEAR: Export Control and RIN 1991-AB99,'' by any of the following methods...

Influence of export control policy on the competitiveness of machine tool producing organizations

NASA Astrophysics Data System (ADS)

Ahrstrom, Jeffrey D.

The possible influence of export control policies on producers of export controlled machine tools is examined in this quantitative study. International market competitiveness theories hold that market controlling policies such as export control regulations may influence an organization's ability to compete (Burris, 2010). Differences in domestic application of export control policy on machine tool exports may impose throttling effects on the competitiveness of participating firms (Freedenberg, 2010). Commodity shipments from Japan, Germany, and the United States to the Russian market will be examined using descriptive statistics; gravity modeling of these specific markets provides a foundation for comparison to actual shipment data; and industry participant responses to a user developed survey will provide additional data for analysis using a Kruskal-Wallis one-way analysis of variance. There is scarce academic research data on the topic of export control effects within the machine tool industry. Research results may be of interest to industry leadership in market participation decisions, advocacy arguments, and strategic planning. Industry advocates and export policy decision makers could find data of interest in supporting positions for or against modifications of export control policies.

31 CFR 538.510 - Importation and exportation of certain gifts authorized.

Code of Federal Regulations, 2012 CFR

2012-07-01

... Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY SUDANESE SANCTIONS... as gifts between individuals; and the goods are not controlled for chemical and biological weapons... Control List, 15 CFR part 774 of the Export Administration Regulations). ...

78 FR 22659 - Revisions to the Export Administration Regulations: Initial Implementation of Export Control Reform

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-16

... Designed'' Definition B. Other Definitions XXIV. Part 774--The Commerce Control List A. Product Group... Changes H. Country Groups XII. Part 742--Control Policy A. National Security (NS) Review Policy B...-all controls on parts, components, accessories, and attachments specifically designed or modified for...

31 CFR 560.506 - Importation and exportation of certain gifts authorized.

Code of Federal Regulations, 2014 CFR

2014-07-01

... Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY IRANIAN TRANSACTIONS AND... controlled for chemical and biological weapons (CB), missile technology (MT), national security (NS), or nuclear proliferation (NP). See Commerce Control List, Export Administration Regulations (15 CFR part 774). ...

31 CFR 560.506 - Importation and exportation of certain gifts authorized.

Code of Federal Regulations, 2013 CFR

2013-07-01

... Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY IRANIAN TRANSACTIONS AND... controlled for chemical and biological weapons (CB), missile technology (MT), national security (NS), or nuclear proliferation (NP). See Commerce Control List, Export Administration Regulations (15 CFR part 774). ...

31 CFR 560.506 - Importation and exportation of certain gifts authorized.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY IRANIAN... controlled for chemical and biological weapons (CB), missile technology (MT), national security (NS), or nuclear proliferation (NP). See Commerce Control List, Export Administration Regulations (15 CFR part 774...

31 CFR 538.510 - Importation and exportation of certain gifts authorized.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY SUDANESE... normally given as gifts between individuals; and the goods are not controlled for chemical and biological... Control List, 15 CFR part 774 of the Export Administration Regulations). ...

76 FR 76072 - Revisions to the Export Administration Regulations (EAR): Control of Gas Turbine Engines and...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-06

... WAML numbering approach, BIS believes that it would be more efficient to list all 600 series controls... ``specially designed'' for articles in the relevant 600 series ECCN and corresponding USML category. ECCN... export of a 600 series item is eligible for License Exception STA if, at the time of export, reexport or...

AKT3 controls mitochondrial biogenesis and autophagy via regulation of the major nuclear export protein CRM-1

PubMed Central

Corum, Daniel G.; Tsichlis, Philip N.; Muise-Helmericks, Robin C.

2014-01-01

Our previous work has shown that Akt3 is required for mitochondrial biogenesis in primary human endothelial cells (ECs) and in Akt3-null mice; Akt3 affects subcellular localization of peroxisome proliferator-activated receptor γ coactivator-1 (PGC-1α), the master regulator of mitochondrial biogenesis. The purpose of this study is to determine the mechanism by which Akt3 controls the subcellular distribution of PGC-1α and to explore the effect on mitochondrial biogenesis and turnover during angiogenesis. Here we use standard biochemical analyses and Akt3-knockdown strategies to show that Akt3 controls the stabilization of chromosome maintenance region-1 (CRM-1), the major nuclear export receptor. Site-directed mutagenesis and association analyses show that PGC-1α nuclear export is CRM-1 dependent. Akt3 knockdown and CRM-1 overexpression cause 3-fold reductions in PGC-1α target gene expression, compared to control levels. Akt3 inhibition causes autophagy, as measured by autophagosome formation, in a CRM-1-dependent, Akt1/mTOR-independent pathway. In vivo, Akt3-null and heterozygous mice show dose-dependent decreases in angiogenesis compared to wild-type littermates (∼5- and 2.5-fold decreases, respectively), as assessed by Matrigel plug assays. This correlates with an ∼1.5-fold decrease in mitochondrial Cox IV expression. Our studies suggest that Akt3 is a regulator of mitochondrial dynamics in the vasculature via regulation of CRM-1-dependent nuclear export.—Corum, D. G., Tsichlis, P. N., Muise-Helmericks, R. C. AKT3 controls mitochondrial biogenesis and autophagy via regulation of the major nuclear export protein CRM-1. PMID:24081905

22 CFR 126.10 - Disclosure of information.

Code of Federal Regulations, 2011 CFR

2011-04-01

....10 Foreign Relations DEPARTMENT OF STATE INTERNATIONAL TRAFFIC IN ARMS REGULATIONS GENERAL POLICIES... Trade Controls. (b) Determinations required by law. Section 38(e) of the Arms Export Control Act (22 U.S... of certain persons, in accordance with Section 38 of the Arms Export Control Act. The requirements...

Rethinking Import and Export Controls for Defense-Related Goods

DTIC Science & Technology

2013-05-01

restrictions were imposed on the basis of country (Trading with the Enemy Act) or product (Neutrality Act). However, in the post-war environment, a more mixed...described below. • Arms Export Control Act (AECA) of 1976—grants the President the power to control the export of defense products and services. The act...defense-related items and services. The products regulated include weapons systems (e.g., aircraft, tanks, etc.) but also include subsystems or

Revision of Import and Export Requirements for Controlled Substances, Listed Chemicals, and Tableting and Encapsulating Machines, Including Changes To Implement the International Trade Data System (ITDS); Revision of Reporting Requirements for Domestic Transactions in Listed Chemicals and Tableting and Encapsulating Machines; and Technical Amendments. Final rule.

PubMed

2016-12-30

The Drug Enforcement Administration is updating its regulations for the import and export of tableting and encapsulating machines, controlled substances, and listed chemicals, and its regulations relating to reports required for domestic transactions in listed chemicals, gamma-hydroxybutyric acid, and tableting and encapsulating machines. In accordance with Executive Order 13563, the Drug Enforcement Administration has reviewed its import and export regulations and reporting requirements for domestic transactions in listed chemicals (and gamma-hydroxybutyric acid) and tableting and encapsulating machines, and evaluated them for clarity, consistency, continued accuracy, and effectiveness. The amendments clarify certain policies and reflect current procedures and technological advancements. The amendments also allow for the implementation, as applicable to tableting and encapsulating machines, controlled substances, and listed chemicals, of the President's Executive Order 13659 on streamlining the export/import process and requiring the government-wide utilization of the International Trade Data System (ITDS). This rule additionally contains amendments that implement recent changes to the Controlled Substances Import and Export Act (CSIEA) for reexportation of controlled substances among members of the European Economic Area made by the Improving Regulatory Transparency for New Medical Therapies Act. The rule also includes additional substantive and technical and stylistic amendments.

The localization of nuclear exporters of the importin-beta family is regulated by Snf1 kinase, nutrient supply and stress.

PubMed

Quan, XinXin; Yu, Jennifer; Bussey, Howard; Stochaj, Ursula

2007-07-01

In the budding yeast Saccharomyces cerevisiae, four members of the importin-beta family of nuclear carriers, Xpo1p/Crm1p, Cse1p, Msn5p and Los1p, function as exporters of protein and tRNA. Under normal growth conditions GFP-tagged exporters are predominantly associated with nuclei. The presence of Snf1 kinase, a key regulator of cell growth and a metabolic sensor, controls the localization of GFP-exporters. Additional glucose-dependent, but Snf1-independent, mechanisms regulate carrier distribution and a switch from fermentable to non-fermentable carbon sources relocates all of the carriers, suggesting a link to the nutritional status of the cell. Moreover, stress controls the proper localization of GFP-exporters, which mislocalize upon exposure to heat, ethanol and starvation. Stress may activate the MAPK cell integrity cascade, and we tested the role of this pathway in exporter localization. Under non-stress conditions, the proper distribution of GFP-Cse1p and Xpo1p/Crm1p-GFP requires kinases of the cell integrity cascade. By contrast, Msn5p-GFP and Los1p-GFP rely on the MAPK module to relocate to the cytoplasm when cells are stressed with ethanol. Our results indicate that the association of nuclear exporters with nuclei is controlled by multiple mechanisms that are organized in a hierarchical fashion and linked to the physiological state of the cell.

Role of ER Export Signals in Controlling Surface Potassium Channel Numbers

NASA Astrophysics Data System (ADS)

Ma, Dzwokai; Zerangue, Noa; Lin, Yu-Fung; Collins, Anthony; Yu, Mei; Jan, Yuh Nung; Yeh Jan, Lily

2001-01-01

Little is known about the identity of endoplasmic reticulum (ER) export signals and how they are used to regulate the number of proteins on the cell surface. Here, we describe two ER export signals that profoundly altered the steady-state distribution of potassium channels and were required for channel localization to the plasma membrane. When transferred to other potassium channels or a G protein-coupled receptor, these ER export signals increased the number of functional proteins on the cell surface. Thus, ER export of membrane proteins is not necessarily limited by folding or assembly, but may be under the control of specific export signals.

A Proven Method for Meeting Export Control Objectives in Postal and Shipping Sectors

DTIC Science & Technology

2015-02-01

months, the USPIS team developed and implemented an export screening standard operating procedure, implemented new and updated processes and systems ...support and protect the U.S. Postal Service and its employees, infrastructure, and customers; enforce the laws that defend the nation’s mail system ...the incidence of mail shipments violating export control laws, regulations, and standards . • Evaluate current processes and systems and identify

32 CFR 250.9 - Notice to accompany the dissemination of export-controlled technical data.

Code of Federal Regulations, 2010 CFR

2010-07-01

... PUBLIC DISCLOSURE § 250.9 Notice to accompany the dissemination of export-controlled technical data. (a... for items controlled by the International Traffic in Arms Regulations (ITAR), or the Department of... not include or involve any license rights. (h) A copy of this notice shall be provided with any...

15 CFR 720.4 - Effect of denial.

Code of Federal Regulations, 2012 CFR

2012-01-01

... considered a “person denied export privileges” for purposes of the Export Administration Regulations (EAR... EAR are published in the Federal Register when they are issued and are legally controlling documents...

15 CFR 720.4 - Effect of denial.

Code of Federal Regulations, 2013 CFR

2013-01-01

... considered a “person denied export privileges” for purposes of the Export Administration Regulations (EAR... EAR are published in the Federal Register when they are issued and are legally controlling documents...

15 CFR 720.4 - Effect of denial.

Code of Federal Regulations, 2014 CFR

2014-01-01

... considered a “person denied export privileges” for purposes of the Export Administration Regulations (EAR... EAR are published in the Federal Register when they are issued and are legally controlling documents...

15 CFR Supplement No. 2 to Part 730 - Technical Advisory Committees

Code of Federal Regulations, 2011 CFR

2011-01-01

... (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE EXPORT ADMINISTRATION REGULATIONS GENERAL..., materials, or supplies, including technology, software, and other information, that are subject to export controls, or are being considered for such controls because of their significance to the national security...

78 FR 18814 - Amendment to the Export Administration Regulations: List of Items Classified Under Export Control...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-28

... RIN 0694-AF73. FOR FURTHER INFORMATION CONTACT: Elizabeth Sangine, Director, Chemical and Biological... detection, identification, warning or monitoring of biological agents that is subject to the licensing... approved collections: (1) The Simplified Network Application Processing + System (control number 0694-0088...

Export Controls and the Tensions between Academic Freedom and National Security

ERIC Educational Resources Information Center

Evans, Samuel A. W.; Valdivia, Walter D.

2012-01-01

In the U.S.A., advocates of academic freedom--the ability to pursue research unencumbered by government controls--have long found sparring partners in government officials who regulate technology trade. From concern over classified research in the 1950s, to the expansion of export controls to cover trade in information in the 1970s, to current…

78 FR 75458 - Addition of Certain Persons to the Entity List; Amendment of Entity List Entries; and Removal of...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-12

... and export control violations involving abuse of human rights. Certain exports, reexports, and... (Control Policy: End-User and End-Use Based) of the EAR. The End-user Review Committee (ERC), composed of... Assets Control regulations and the EAR: Anvik Technologies Sdn. Bhd., Montana Advanced Engineering Sdn...

77 FR 71213 - Revisions to the Export Administration Regulations (EAR) To Make the Commerce Control List (CCL...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-29

...On December 9, 2010, the Bureau of Industry and Security (BIS) published an advance notice of proposed rulemaking entitled Commerce Control List: Revising Descriptions of Items and Foreign Availability as part of the President's Export Control Reform (ECR) Initiative. The December 9, 2010 notice sought, among other things, public comments on how descriptions of items controlled on the Commerce Control List (CCL) could be made clearer. This proposed rule would implement changes identified by BIS and the public that would make the CCL clearer. This rule would only implement changes that can be made to the CCL without requiring changes to multilateral export control regime guidelines or lists. However, BIS has identified changes that would require a decision of a multilateral regime to implement. For those changes, the U.S. Government is developing regime change proposals for consideration by members of those multilateral export control regimes. BIS will implement those changes in separate rulemakings, if approved by the respective multilateral export control regimes.

22 CFR 124.3 - Exports of technical data in furtherance of an agreement.

Code of Federal Regulations, 2010 CFR

2010-04-01

... approved in writing by the Directorate of Defense Trade Controls (DDTC) and the technical data does not... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Exports of technical data in furtherance of an... REGULATIONS AGREEMENTS, OFF-SHORE PROCUREMENT AND OTHER DEFENSE SERVICES § 124.3 Exports of technical data in...

31 CFR 592.502 - Annual reports by rough diamond importers and exporters.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 31 Money and Finance:Treasury 3 2012-07-01 2012-07-01 false Annual reports by rough diamond... and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY ROUGH DIAMONDS CONTROL REGULATIONS Records and Reports § 592.502 Annual reports by rough diamond importers and exporters...

31 CFR 592.502 - Annual reports by rough diamond importers and exporters.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 31 Money and Finance:Treasury 3 2014-07-01 2014-07-01 false Annual reports by rough diamond... and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY ROUGH DIAMONDS CONTROL REGULATIONS Records and Reports § 592.502 Annual reports by rough diamond importers and exporters...

31 CFR 592.502 - Annual reports by rough diamond importers and exporters.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 31 Money and Finance:Treasury 3 2011-07-01 2011-07-01 false Annual reports by rough diamond... and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY ROUGH DIAMONDS CONTROL REGULATIONS Records and Reports § 592.502 Annual reports by rough diamond importers and exporters...

31 CFR 592.502 - Annual reports by rough diamond importers and exporters.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 31 Money and Finance:Treasury 3 2013-07-01 2013-07-01 false Annual reports by rough diamond... and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY ROUGH DIAMONDS CONTROL REGULATIONS Records and Reports § 592.502 Annual reports by rough diamond importers and exporters...

77 FR 12201 - Amendment to the International Traffic in Arms Regulations: Haiti

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-29

... controlling the import and export of defense articles and services is a foreign affairs function of the United... Department is of the opinion that controlling the import and export of defense articles and services is a... this rulemaking will not have tribal implications, will not impose substantial direct compliance costs...

AKT3 controls mitochondrial biogenesis and autophagy via regulation of the major nuclear export protein CRM-1.

PubMed

Corum, Daniel G; Tsichlis, Philip N; Muise-Helmericks, Robin C

2014-01-01

Our previous work has shown that Akt3 is required for mitochondrial biogenesis in primary human endothelial cells (ECs) and in Akt3-null mice; Akt3 affects subcellular localization of peroxisome proliferator-activated receptor γ coactivator-1 (PGC-1α), the master regulator of mitochondrial biogenesis. The purpose of this study is to determine the mechanism by which Akt3 controls the subcellular distribution of PGC-1α and to explore the effect on mitochondrial biogenesis and turnover during angiogenesis. Here we use standard biochemical analyses and Akt3-knockdown strategies to show that Akt3 controls the stabilization of chromosome maintenance region-1 (CRM-1), the major nuclear export receptor. Site-directed mutagenesis and association analyses show that PGC-1α nuclear export is CRM-1 dependent. Akt3 knockdown and CRM-1 overexpression cause 3-fold reductions in PGC-1α target gene expression, compared to control levels. Akt3 inhibition causes autophagy, as measured by autophagosome formation, in a CRM-1-dependent, Akt1/mTOR-independent pathway. In vivo, Akt3-null and heterozygous mice show dose-dependent decreases in angiogenesis compared to wild-type littermates (~5- and 2.5-fold decreases, respectively), as assessed by Matrigel plug assays. This correlates with an ~1.5-fold decrease in mitochondrial Cox IV expression. Our studies suggest that Akt3 is a regulator of mitochondrial dynamics in the vasculature via regulation of CRM-1-dependent nuclear export.

75 FR 18029 - Defense Federal Acquisition Regulation Supplement; Export-Controlled Items (DFARS Case 2004-D010)

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-08

... increased security benefits will be reaped if DoD diligently identifies those portions of fundamental.... Fundamental Research and the Clause at DFARS 252.204-7000, Disclosure of Information Comments: The fundamental..., universities under contracts with DoD can and do have access to export-controlled items in fundamental research...

22 CFR 126.6 - Foreign-owned military aircraft and naval vessels, and the Foreign Military Sales program.

Code of Federal Regulations, 2011 CFR

2011-04-01

... INTERNATIONAL TRAFFIC IN ARMS REGULATIONS GENERAL POLICIES AND PROVISIONS § 126.6 Foreign-owned military... pursuant to the Arms Export Control Act or the Foreign Assistance Act of 1961, as amended, and (2) The... the Arms Export Control Act pursuant to an Letter of Offer and Acceptance (LOA) authorizing such...

78 FR 22740 - Amendment to the International Traffic in Arms Regulations: Initial Implementation of Export...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-16

...As part of the President's Export Control Reform (ECR) effort, the Department of State is amending the International Traffic in Arms Regulations (ITAR) to revise four U.S Munitions List (USML) categories and provide new definitions and other changes. Additionally, policies and procedures regarding the licensing of items moving from the export jurisdiction of the Department of State to the Department of Commerce are provided. The revisions contained in this rule are part of the Department of State's retrospective plan under E.O. 13563 completed on August 17, 2011.

77 FR 29564 - Revisions to the Export Administration Regulations: Auxiliary and Miscellaneous Items That No...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-18

...The Bureau of Industry and Security (BIS) publishes this action to propose how auxiliary and miscellaneous military equipment and related articles the President determines no longer warrant control under Category XIII (Auxiliary Military Equipment) of the United States Munitions List (USML) would be controlled under the Commerce Control List (CCL) in new Export Control Classification Numbers (ECCNs) 0A617, 0B617, 0C617, 0D617, and 0E617 as part of the proposed new ``600 series'' of ECCNs. This rule proposes also to integrate into those five new ECCNs items within the scope of Wassenaar Arrangement Munitions List (WAML) Category 17 that would be removed from the USML, or that are not specifically identified on the USML or CCL but that are currently subject to USML jurisdiction. Finally, this rule proposes to control some items now classified under ECCNs 0A018, 0A918 and 0E018 under new ECCNs 0A617 and 0E617. This action would consolidate the above- mentioned auxiliary and miscellaneous military equipment and related articles on the CCL in the proposed new ``600 series.'' This rule is one of a planned series proposing how various types of articles that the President determines, as part of the Administration's Export Control Reform Initiative, no longer warrant control on the USML under the International Traffic in Arms Regulations (ITAR), would be controlled on the CCL in accordance with the requirements of the Export Administration Regulations (EAR). This proposed rule is being published in conjunction with a proposed rule from the Department of State, Directorate of Defense Trade Controls, which would amend the list of articles controlled by USML Category XIII.

15 CFR 742.15 - Encryption items.

Code of Federal Regulations, 2010 CFR

2010-01-01

... Memorandum of November 15, 1996, exports and reexports of encryption software, like exports and reexports of... because of any informational or theoretical value that such software may reflect, contain, or represent... encryption software are distinguished from controls on other software regulated under the EAR. (a) Licensing...

U.S. government export control reform initiative - what's going on?

NASA Astrophysics Data System (ADS)

Cook, J.; Cook, K.

While there is still more work to be done, taken together, these reforms will focus our resources on the threats that matter most, and help us work more effectively with our allies in the field. They'll bring transparency and coherence to a field of regulation which has long been lacking both. And by enhancing the competitiveness of our manufacturing and technology sectors, they'll help us not just increase exports and create jobs, but strengthen our national security as well.” - President Obama, Department of Commerce Annual Export Controls Update Conference, August 30, 2010. This paper will provide background information and discuss the need for export control reform. It will lay out the schedule for the Export Control Reform Initiative as well as provide an update on the current status of the ECR Initiative, including advances made in Phases I and II. It will provide insight into the proposed changes to the USML and the CCL and will discuss the proposed IT system modernization and the Export Enforcement Coordination Center (E2C2).

Regulation of RNA-binding proteins affinity to export receptors enables the nuclear basket proteins to distinguish and retain aberrant mRNAs

PubMed Central

Soheilypour, M.; Mofrad, M. R. K.

2016-01-01

Export of messenger ribonucleic acids (mRNAs) into the cytoplasm is a fundamental step in gene regulation processes, which is meticulously quality controlled by highly efficient mechanisms in eukaryotic cells. Yet, it remains unclear how the aberrant mRNAs are recognized and retained inside the nucleus. Using a new modelling approach for complex systems, namely the agent-based modelling (ABM) approach, we develop a minimal model of the mRNA quality control (QC) mechanism. Our results demonstrate that regulation of the affinity of RNA-binding proteins (RBPs) to export receptors along with the weak interaction between the nuclear basket protein (Mlp1 or Tpr) and RBPs are the minimum requirements to distinguish and retain aberrant mRNAs. Our results show that the affinity between Tpr and RBPs is optimized to maximize the retention of aberrant mRNAs. In addition, we demonstrate how the length of mRNA affects the QC process. Since longer mRNAs spend more time in the nuclear basket to form a compact conformation and initiate their export, nuclear basket proteins could more easily capture and retain them inside the nucleus. PMID:27805000

Regulation of RNA-binding proteins affinity to export receptors enables the nuclear basket proteins to distinguish and retain aberrant mRNAs.

PubMed

Soheilypour, M; Mofrad, M R K

2016-11-02

Export of messenger ribonucleic acids (mRNAs) into the cytoplasm is a fundamental step in gene regulation processes, which is meticulously quality controlled by highly efficient mechanisms in eukaryotic cells. Yet, it remains unclear how the aberrant mRNAs are recognized and retained inside the nucleus. Using a new modelling approach for complex systems, namely the agent-based modelling (ABM) approach, we develop a minimal model of the mRNA quality control (QC) mechanism. Our results demonstrate that regulation of the affinity of RNA-binding proteins (RBPs) to export receptors along with the weak interaction between the nuclear basket protein (Mlp1 or Tpr) and RBPs are the minimum requirements to distinguish and retain aberrant mRNAs. Our results show that the affinity between Tpr and RBPs is optimized to maximize the retention of aberrant mRNAs. In addition, we demonstrate how the length of mRNA affects the QC process. Since longer mRNAs spend more time in the nuclear basket to form a compact conformation and initiate their export, nuclear basket proteins could more easily capture and retain them inside the nucleus.

Factors controlling the long-term temporal and spatial patterns of nitrate-nitrogen export in a dairy farming watershed.

PubMed

Jiang, Rui; Wang, Chun-ying; Hatano, Ryusuke; Kuramochi, Kanta; Hayakawa, Atsushi; Woli, Krishna P

2015-04-01

It is difficult to investigate the factors that control the riverine nitrate-nitrogen (NO3--N) export in a watershed which gains or losses groundwater. To control the NO3--N contamination in these watersheds, it is necessary to investigate the factors that are related to the export of NO3--N that is only produced by the watershed itself. This study was conducted in the Shibetsu watershed located in eastern Hokkaido, Japan, which gains external groundwater contribution (EXT) and 34% of the annual NO3--N loading occurs through EXT. The riverine NO3--N exports from 1980 to 2009 were simulated by the SWAT model, and the factors controlling the temporal and spatial patterns of NO3--N exports were investigated without considering the EXT. The results show that hydrological events control NO3--N export at the seasonal scale, while the hydrological and biogeochemical processes are likely to control NO3--N export at the annual scale. There was an integrated effect among the land use, topography, and soil type related to denitrification process, that regulated the spatial patterns of NO3--N export. The spatial distribution of NO3--N export from hydrologic response units (HRUs) identified the agricultural areas with surplus N that are vulnerable to nitrate contamination. A new standard for the N fertilizer application rate including manure application should be given to control riverine NO3--N export. This study demonstrates that applying the SWAT model is an appropriate method to determine the temporal and spatial patterns of NO3--N export from the watershed which includes EXT and to identify the crucial pollution areas within a watershed in which the management practices can be improved to more effectively control NO3--N export to water bodies.

HIV-1 Rev protein specifies the viral RNA export pathway by suppressing TAP/NXF1 recruitment

PubMed Central

Taniguchi, Ichiro; Mabuchi, Naoto; Ohno, Mutsuhito

2014-01-01

Nuclear RNA export pathways in eukaryotes are often linked to the fate of a given RNA. Therefore, the choice of export pathway should be well-controlled to avoid an unfavorable effect on gene expression. Although some RNAs could be exported by more than one pathway, little is known about how the choice is regulated. This issue is highlighted when the human immunodeficiency virus type 1 (HIV-1) Rev protein induces the export of singly spliced and unspliced HIV-1 transcripts. How these RNAs are exported is not well understood because such transcripts should have the possibility of utilizing CRM1-dependent export via Rev or cellular TAP/NXF1-dependent export via the transcription/export (TREX) complex, or both. Here we found that Rev suppressed TAP/NXF1-dependent export of model RNA substrates that recapitulated viral transcripts. In this effect, Rev interacted with the cap-binding complex and inhibited the recruitment of the TREX complex. Thus, Rev controls the identity of the factor occupying the cap-proximal region that determines the RNA export pathway. This ribonucleoprotein remodeling activity of Rev may favor viral gene expression. PMID:24753416

31 CFR 500.533 - Exportations, reexportations, and incidental transactions.

Code of Federal Regulations, 2010 CFR

2010-07-01

... CONTROL REGULATIONS Licenses, Authorizations and Statements of Licensing Policy § 500.533 Exportations..., software, or technology (including technical data) from the United States or reexportation of U.S.-origin goods, software, or technology from a foreign country to any person in a designated foreign country or...

75 FR 8917 - Action Affecting Export Privileges; Afshin Rezaei

Federal Register 2010, 2011, 2012, 2013, 2014

2010-02-26

... DEPARTMENT OF COMMERCE Bureau of Industry and Security Action Affecting Export Privileges; Afshin... any item subject to the Regulations; B. Take any action that facilitates the acquisition or attempted..., possession or control; C. Take any action to acquire from or to facilitate the acquisition or attempted...

15 CFR 752.11 - Internal Control Programs.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 15 Commerce and Foreign Trade 2 2010-01-01 2010-01-01 false Internal Control Programs. 752.11 Section 752.11 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE EXPORT ADMINISTRATION REGULATIONS SPECIAL COMPREHENSIVE LICENSE § 752.11 Internal Control...

76 FR 68675 - Revisions to the Export Administration Regulations (EAR): Control of Aircraft and Related Items...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-07

...(g) of the July 15 proposed rule) and all other 600 series items if, at the time of export, reexport... designed'' for a defense article would become subject to the new 600 series controls on the CCL as... the extent an item is ``specially designed'' for a military use, it is subject to a 600 series ECCN in...

A peptide export-import control circuit modulating bacterial development regulates protein phosphatases of the phosphorelay.

PubMed

Perego, M

1997-08-05

The phosphorelay signal transduction system activates developmental transcription in sporulation of Bacillus subtilis by phosphorylation of aspartyl residues of the Spo0F and Spo0A response regulators. The phosphorylation level of these response regulators is determined by the opposing activities of protein kinases and protein aspartate phosphatases that interpret positive and negative signals for development in a signal integration circuit. The RapA protein aspartate phosphatase of the phosphorelay is regulated by a peptide that directly inhibits its activity. This peptide is proteolytically processed from an inactive pre-inhibitor protein encoded in the phrA gene. The pre-inhibitor is cleaved by the protein export apparatus to a putative pro-inhibitor that is further processed to the active inhibitor peptide and internalized by the oligopeptide permease. This export-import circuit is postulated to be a mechanism for timing phosphatase activity where the processing enzymes regulate the rate of formation of the active inhibitor. The processing events may, in turn, be controlled by a regulatory hierarchy. Chromosome sequencing has revealed several other phosphatase-prepeptide gene pairs in B. subtilis, suggesting that the use of this mechanism may be widespread in signal transduction.

15 CFR 748.9 - Support documents for license applications.

Code of Federal Regulations, 2014 CFR

2014-01-01

... Foreign Aid, U.S. Agency for International Development, for export to a member agency in the foreign... circumstances beyond your control. An exception will not be granted contrary to the objectives of the U.S... (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE EXPORT ADMINISTRATION REGULATIONS...

15 CFR 748.9 - Support documents for license applications.

Code of Federal Regulations, 2012 CFR

2012-01-01

... Foreign Aid, U.S. Agency for International Development, for export to a member agency in the foreign... circumstances beyond your control. An exception will not be granted contrary to the objectives of the U.S... (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE EXPORT ADMINISTRATION REGULATIONS...

15 CFR 748.9 - Support documents for license applications.

Code of Federal Regulations, 2013 CFR

2013-01-01

... Foreign Aid, U.S. Agency for International Development, for export to a member agency in the foreign... circumstances beyond your control. An exception will not be granted contrary to the objectives of the U.S... (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE EXPORT ADMINISTRATION REGULATIONS...

75 FR 28848 - Lifting of Policy of Denial of Munitions Export Licenses and Other Approvals Destined for Tula...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-24

...The Department of State is lifting the policy of denial for Tula Instrument Design Bureau pursuant to section 38 of the Arms Export Control Act (AECA) and section 126.7 of the International Traffic in Arms Regulations (ITAR).

22 CFR 120.27 - U.S. criminal statutes.

Code of Federal Regulations, 2014 CFR

2014-04-01

... Foreign Relations DEPARTMENT OF STATE INTERNATIONAL TRAFFIC IN ARMS REGULATIONS PURPOSE AND DEFINITIONS... means: (1) Section 38 of the Arms Export Control Act (22 U.S.C. 2778); (2) Section 11 of the Export... underlying offense involves a defense article, including technical data, or violations related to the Arms...

75 FR 32742 - Action Affecting Export Privileges; Joseph Piquet

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-09

... DEPARTMENT OF COMMERCE Bureau of Industry and Security Action Affecting Export Privileges; Joseph... on behalf of the Denied Person any item subject to the Regulations; B. Take any action that... or attempts to acquire such ownership, possession or control; C. Take any action to acquire from or...

76 FR 13127 - Action Affecting Export Privileges; Amy Farrow

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-10

... DEPARTMENT OF COMMERCE Bureau of Industry and Security Action Affecting Export Privileges; Amy... reexport to or on behalf of the Denied Person any item subject to the Regulations; B. Take any action that... Denied Person acquires or attempts to acquire such ownership, possession or control; C. Take any action...

7 CFR 33.60 - OMB control number assigned pursuant to the Paperwork Reduction Act.

Code of Federal Regulations, 2010 CFR

2010-01-01

... MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE COMMODITY STANDARDS AND STANDARD CONTAINER REGULATIONS REGULATIONS ISSUED UNDER AUTHORITY OF THE EXPORT APPLE ACT...

76 FR 58396 - Editorial Correction to the Export Administration Regulations

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-21

... No. 100325169-0629-01] RIN 0694-AE90 Editorial Correction to the Export Administration Regulations... reference and typographical errors in the Export Administration Regulations (EAR). The corrections are...: Sec. 772.1 Definitions of terms as used in the Export Administration Regulations (EAR...

75 FR 31678 - Export Administration Regulations: Technical Corrections

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-04

... and 774 [Docket No. 0907271167-91198-01] RIN 0694-AE69 Export Administration Regulations: Technical... clarifies language concerning the de minimis provisions of the Export Administration Regulations and certain... Items The Export Administration Regulations (EAR) generally do not apply to items that were made and are...

Inspection of the Department`s export licensing process for dual-use and munitions commodities

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1993-08-10

The purpose of our inspection was to review the Department of Energy`s (Energy) export licensing process for dual-use and military (munitions) commodities subject to nuclear nonproliferation controls. Specifically, we reviewed Energy`s authorities, procedures, and policies pertaining to the export licensing process and examined procedures for safeguarding data transmitted between Energy and other agencies involved in the export licensing process. We also reviewed Energy`s role as a member of the Subgroup on Nuclear Export Coordination. Our review of the sample of 60 export cases did not find evidence to lead us to believe that Energy`s recommendations for these cases were inappropriatemore » or incorrect. We identified, however, problems regarding management systems associated with the export license review process. We found that without documentation supporting export licensing decisions by the Export Control Operations Division (ECOD), we could not determine whether ECOD analysts considered all required criteria in their review of export cases referred to Energy. For example, we found that the ECOD did not retain records documenting the bases for its advice, recommendations, or decisions regarding its reviews of export license cases or revisions to lists of controlled commodities and, therefore, was not in compliance with certain provisions of the Export Administration Act, as amended, and Energy records management directives. Additionally, we found that the degree of compliance by Energy with the export licensing review criteria contained in the Export Administration Regulations and the Nuclear Non-Proliferation Act of 1978 could not be determined because ECOD did not retain records documenting the bases for its advice and recommendations on export cases.« less

Military Standard. Marking Technical Data Prepared by or for the Department of Defense

DTIC Science & Technology

1990-02-01

Regulations f. ECCN - Export Commodity Control Number g. ED - Executive Order h. FOIA - Freedom of Information Act i. IEP - International Exchange...critical are explicitly covered in the CCL, ",, the Export Commodity Control Number ( ECCN ) reference is provided. In o~ner cases where the ECCN statement...controlling mechanism is in supplement three of the EAR. 3,7 MIL-STD-1806 APPENDIX B A listing such as " ECCN 1355A" means the technology is specifically

75 FR 36511 - Revisions to the Export Administration Regulations Based Upon a Systematic Review of the Commerce...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-28

... DEPARTMENT OF COMMERCE Bureau of Industry and Security 15 CFR Parts 734, 738, 740, 742, 772, and... Based Upon a Systematic Review of the Commerce Control List: Additional Changes AGENCY: Bureau of Industry and Security, Commerce. ACTION: Final rule. SUMMARY: This rule amends the Export Administration...

31 CFR 537.202 - Prohibited exportation or reexportation of financial services to Burma.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 31 Money and Finance:Treasury 3 2011-07-01 2011-07-01 false Prohibited exportation or reexportation of financial services to Burma. 537.202 Section 537.202 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY...

31 CFR 538.205 - Prohibited exportation and reexportation of goods, technology, or services to Sudan.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 31 Money and Finance:Treasury 3 2011-07-01 2011-07-01 false Prohibited exportation and reexportation of goods, technology, or services to Sudan. 538.205 Section 538.205 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE...

22 CFR 120.27 - U.S. criminal statutes.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 22 Foreign Relations 1 2013-04-01 2013-04-01 false U.S. criminal statutes. 120.27 Section 120.27 Foreign Relations DEPARTMENT OF STATE INTERNATIONAL TRAFFIC IN ARMS REGULATIONS PURPOSE AND DEFINITIONS... means: (1) Section 38 of the Arms Export Control Act (22 U.S.C. 2778); (2) Section 11 of the Export...

22 CFR 120.27 - U.S. criminal statutes.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 22 Foreign Relations 1 2011-04-01 2011-04-01 false U.S. criminal statutes. 120.27 Section 120.27 Foreign Relations DEPARTMENT OF STATE INTERNATIONAL TRAFFIC IN ARMS REGULATIONS PURPOSE AND DEFINITIONS... means: (1) Section 38 of the Arms Export Control Act (22 U.S.C. 2778); (2) Section 11 of the Export...

22 CFR 120.27 - U.S. criminal statutes.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 22 Foreign Relations 1 2012-04-01 2012-04-01 false U.S. criminal statutes. 120.27 Section 120.27 Foreign Relations DEPARTMENT OF STATE INTERNATIONAL TRAFFIC IN ARMS REGULATIONS PURPOSE AND DEFINITIONS... means: (1) Section 38 of the Arms Export Control Act (22 U.S.C. 2778); (2) Section 11 of the Export...

75 FR 14335 - Revisions to the Export Administration Regulations To Enhance U.S. Homeland Security: Addition of...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-25

... identified by an interagency working group that is reviewing export control issues related to homeland security. The interagency working group is made up of representatives from the Departments of Commerce, Defense, Homeland Security and State. The purpose of the interagency working group is to ensure that...

15 CFR 30.17 - Customs and Border Protection regulations.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 15 Commerce and Foreign Trade 1 2010-01-01 2010-01-01 false Customs and Border Protection regulations. 30.17 Section 30.17 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade BUREAU OF THE CENSUS, DEPARTMENT OF COMMERCE FOREIGN TRADE REGULATIONS Export Control and Licensing...

76 FR 80282 - Revisions to the Export Administration Regulations (EAR): Control of Vessels of War and Related...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-23

... (ECCNs) 8A609, 8B609, 8C609, 8D609, and 8E609. This rule is one of a planned series of proposed rules... controlled on the CCL--the military vehicles proposal was the first in a series of such proposed rules to be... additional exceptions. The goal of such amendments would be to give exporters sufficient time to implement...

15 CFR Supplement No. 1 to Part 774 - The Commerce Control List

Code of Federal Regulations, 2010 CFR

2015-01-01

... 15 Commerce and Foreign Trade 2 2015-01-01 2015-01-01 false The Commerce Control List No. Supplement No. 1 to Part 774 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE EXPORT ADMINISTRATION REGULATIONS THE COMMERCE CONTROL LIST Pt. 774, Supp. 1...

15 CFR Supplement No. 1 to Part 774 - The Commerce Control List

Code of Federal Regulations, 2010 CFR

2010-01-01

... 15 Commerce and Foreign Trade 2 2010-01-01 2010-01-01 false The Commerce Control List No. Supplement No. 1 to Part 774 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE EXPORT ADMINISTRATION REGULATIONS THE COMMERCE CONTROL LIST Pt. 774, Supp. 1...

15 CFR Supplement No. 1 to Part 774 - The Commerce Control List

Code of Federal Regulations, 2013 CFR

2013-01-01

... 15 Commerce and Foreign Trade 2 2013-01-01 2013-01-01 false The Commerce Control List No. Supplement No. 1 to Part 774 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE EXPORT ADMINISTRATION REGULATIONS THE COMMERCE CONTROL LIST Pt. 774, Supp. 1...

15 CFR Supplement No. 1 to Part 774 - The Commerce Control List

Code of Federal Regulations, 2011 CFR

2011-01-01

... 15 Commerce and Foreign Trade 2 2011-01-01 2011-01-01 false The Commerce Control List No. Supplement No. 1 to Part 774 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE EXPORT ADMINISTRATION REGULATIONS THE COMMERCE CONTROL LIST Pt. 774, Supp. 1...

15 CFR Supplement No. 1 to Part 774 - The Commerce Control List

Code of Federal Regulations, 2012 CFR

2012-01-01

... 15 Commerce and Foreign Trade 2 2012-01-01 2012-01-01 false The Commerce Control List No. Supplement No. 1 to Part 774 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE EXPORT ADMINISTRATION REGULATIONS THE COMMERCE CONTROL LIST Pt. 774, Supp. 1...

15 CFR Supplement No. 1 to Part 774 - The Commerce Control List

Code of Federal Regulations, 2014 CFR

2014-01-01

... 15 Commerce and Foreign Trade 2 2014-01-01 2014-01-01 false The Commerce Control List No. Supplement No. 1 to Part 774 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE EXPORT ADMINISTRATION REGULATIONS THE COMMERCE CONTROL LIST Pt. 774, Supp. 1...

15 CFR 772.1 - Definitions of terms as used in the Export Administration Regulations (EAR).

Code of Federal Regulations, 2010 CFR

2001-01-01

... 15 Commerce and Foreign Trade 2 2001-01-01 2001-01-01 false Definitions of terms as used in the Export Administration Regulations (EAR). 772.1 Section 772.1 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) BUREAU OF EXPORT ADMINISTRATION, DEPARTMENT OF COMMERCE EXPORT ADMINISTRATION REGULATIONS DEFINITION...

15 CFR 772.1 - Definitions of terms as used in the Export Administration Regulations (EAR).

Code of Federal Regulations, 2010 CFR

2002-01-01

... 15 Commerce and Foreign Trade 2 2002-01-01 2002-01-01 false Definitions of terms as used in the Export Administration Regulations (EAR). 772.1 Section 772.1 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) BUREAU OF EXPORT ADMINISTRATION, DEPARTMENT OF COMMERCE EXPORT ADMINISTRATION REGULATIONS DEFINITION...

26 CFR 1.927(a)-1T - Temporary regulations; definition of export property.

Code of Federal Regulations, 2010 CFR

2010-04-01

... as commission agent, to another FSC which is a member of the same controlled group (as defined in... customers generally would not constitute services and would be export property if the requirements of this... manufactured or produced, as defined in § 1.954-3(a)(4). For purposes of this section, however, in determining...

9 CFR 327.2 - Eligibility of foreign countries for importation of products into the United States.

Code of Federal Regulations, 2012 CFR

2012-01-01

... regulations governing meat inspection of the U.S. Department of Agriculture. Control numbers Name Address Date... country, with respect to establishments preparing products in such country for export to the United States... establishments throughout the system at which products are prepared for export to the United States; (B) Ultimate...

9 CFR 327.2 - Eligibility of foreign countries for importation of products into the United States.

Code of Federal Regulations, 2011 CFR

2011-01-01

... regulations governing meat inspection of the U.S. Department of Agriculture. Control numbers Name Address Date... country, with respect to establishments preparing products in such country for export to the United States... establishments throughout the system at which products are prepared for export to the United States; (B) Ultimate...

9 CFR 327.2 - Eligibility of foreign countries for importation of products into the United States.

Code of Federal Regulations, 2013 CFR

2013-01-01

... regulations governing meat inspection of the U.S. Department of Agriculture. Control numbers Name Address Date... country, with respect to establishments preparing products in such country for export to the United States... establishments throughout the system at which products are prepared for export to the United States; (B) Ultimate...

9 CFR 327.2 - Eligibility of foreign countries for importation of products into the United States.

Code of Federal Regulations, 2014 CFR

2014-01-01

... regulations governing meat inspection of the U.S. Department of Agriculture. Control numbers Name Address Date... country, with respect to establishments preparing products in such country for export to the United States... establishments throughout the system at which products are prepared for export to the United States; (B) Ultimate...

77 FR 22191 - Revisions to the Export Administration Regulations (EAR): Export Control Classification Number...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-13

... for one year following the date of Federal Register publication, unless the item is re-classified... two one-year periods to provide time for the U.S. Government and multilateral regime(s) to reach... for no more than two one-year extensions provided that the Departments of Commerce, State and Defense...

Convention on International Trade in Endangered Species of Wild Fauna and Flora.

ERIC Educational Resources Information Center

Supplement to IUCN Bulletin, 1973

1973-01-01

Concern for the endangered species of wild animals and plants of the world prompted the drafting of this international convention regulating the import, export, and re-export of such species. Nations signing this document are required to impose strict controls on the international trade of these plants and animals or their recognizable parts. The…

31 CFR 515.530 - Exportation of powers of attorney or instructions relating to certain types of transactions.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 31 Money and Finance:Treasury 3 2012-07-01 2012-07-01 false Exportation of powers of attorney or instructions relating to certain types of transactions. 515.530 Section 515.530 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE...

31 CFR 515.530 - Exportation of powers of attorney or instructions relating to certain types of transactions.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 31 Money and Finance:Treasury 3 2014-07-01 2014-07-01 false Exportation of powers of attorney or instructions relating to certain types of transactions. 515.530 Section 515.530 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE...

31 CFR 515.530 - Exportation of powers of attorney or instructions relating to certain types of transactions.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 31 Money and Finance:Treasury 3 2011-07-01 2011-07-01 false Exportation of powers of attorney or instructions relating to certain types of transactions. 515.530 Section 515.530 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE...

31 CFR 515.530 - Exportation of powers of attorney or instructions relating to certain types of transactions.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 31 Money and Finance:Treasury 3 2013-07-01 2013-07-01 false Exportation of powers of attorney or instructions relating to certain types of transactions. 515.530 Section 515.530 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE...

27 CFR 478.2 - Relation to other provisions of law.

Code of Federal Regulations, 2010 CFR

2010-04-01

... ammunition. For regulations applicable to traffic in machine guns, destructive devices, and certain other... of war, see section 38 of the Arms Export Control Act (22 U.S.C. 2778) and regulations thereunder and...

27 CFR 478.2 - Relation to other provisions of law.

Code of Federal Regulations, 2013 CFR

2013-04-01

... ammunition. For regulations applicable to traffic in machine guns, destructive devices, and certain other... of war, see section 38 of the Arms Export Control Act (22 U.S.C. 2778) and regulations thereunder and...

27 CFR 478.2 - Relation to other provisions of law.

Code of Federal Regulations, 2014 CFR

2014-04-01

... ammunition. For regulations applicable to traffic in machine guns, destructive devices, and certain other... of war, see section 38 of the Arms Export Control Act (22 U.S.C. 2778) and regulations thereunder and...

27 CFR 478.2 - Relation to other provisions of law.

Code of Federal Regulations, 2012 CFR

2012-04-01

... ammunition. For regulations applicable to traffic in machine guns, destructive devices, and certain other... of war, see section 38 of the Arms Export Control Act (22 U.S.C. 2778) and regulations thereunder and...

27 CFR 478.2 - Relation to other provisions of law.

Code of Federal Regulations, 2011 CFR

2011-04-01

... ammunition. For regulations applicable to traffic in machine guns, destructive devices, and certain other... of war, see section 38 of the Arms Export Control Act (22 U.S.C. 2778) and regulations thereunder and...

77 FR 40493 - Export Administration Regulations

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-10

... 760 Export Administration Regulations CFR Correction In Title 15 of the Code of Federal Regulations... Sec. 740.1, correctly revise the heading of paragraph (d) to read ``Shippers Export Declaration or Automated Export System Record''. 0 2. On page 321, in Sec. 742.15, move the note to introductory paragraph...

Heme controls ferroportin1 (FPN1) transcription involving Bach1, Nrf2 and a MARE/ARE sequence motif at position -7007 of the FPN1 promoter.

PubMed

Marro, Samuele; Chiabrando, Deborah; Messana, Erika; Stolte, Jens; Turco, Emilia; Tolosano, Emanuela; Muckenthaler, Martina U

2010-08-01

Macrophages of the reticuloendothelial system play a key role in recycling iron from hemoglobin of senescent or damaged erythrocytes. Heme oxygenase 1 degrades the heme moiety and releases inorganic iron that is stored in ferritin or exported to the plasma via the iron export protein ferroportin. In the plasma, iron binds to transferrin and is made available for de novo red cell synthesis. The aim of this study was to gain insight into the regulatory mechanisms that control the transcriptional response of iron export protein ferroportin to hemoglobin in macrophages. Iron export protein ferroportin mRNA expression was analyzed in RAW264.7 mouse macrophages in response to hemoglobin, heme, ferric ammonium citrate or protoporphyrin treatment or to siRNA mediated knockdown or overexpression of Btb And Cnc Homology 1 or nuclear accumulation of Nuclear Factor Erythroid 2-like. Iron export protein ferroportin promoter activity was analyzed using reporter constructs that contain specific truncations of the iron export protein ferroportin promoter or mutations in a newly identified MARE/ARE element. We show that iron export protein ferroportin is transcriptionally co-regulated with heme oxygenase 1 by heme, a degradation product of hemoglobin. The protoporphyrin ring of heme is sufficient to increase iron export protein ferroportin transcriptional activity while the iron released from the heme moiety controls iron export protein ferroportin translation involving the IRE in the 5'untranslated region. Transcription of iron export protein ferroportin is inhibited by Btb and Cnc Homology 1 and activated by Nuclear Factor Erythroid 2-like involving a MARE/ARE element located at position -7007/-7016 of the iron export protein ferroportin promoter. This finding suggests that heme controls a macrophage iron recycling regulon involving Btb and Cnc Homology 1 and Nuclear Factor Erythroid 2-like to assure the coordinated degradation of heme by heme oxygenase 1, iron storage and detoxification by ferritin, and iron export by iron export protein ferroportin.

48 CFR 225.7902 - Defense Trade Cooperation Treaties.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 48 Federal Acquisition Regulations System 3 2013-10-01 2013-10-01 false Defense Trade Cooperation Treaties. 225.7902 Section 225.7902 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE SOCIOECONOMIC PROGRAMS FOREIGN ACQUISITION EXPORT CONTROL 225.7902 Defense Trade Cooperation Treaties. This...

48 CFR 225.7902 - Defense Trade Cooperation Treaties.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 48 Federal Acquisition Regulations System 3 2014-10-01 2014-10-01 false Defense Trade Cooperation Treaties. 225.7902 Section 225.7902 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE SOCIOECONOMIC PROGRAMS FOREIGN ACQUISITION EXPORT CONTROL 225.7902 Defense Trade Cooperation Treaties. This...

15 CFR Supplement No. 1 to Part 774 - The Commerce Control List

Code of Federal Regulations, 2010 CFR

2017-01-01

... 15 Commerce and Foreign Trade 2 2017-01-01 2017-01-01 false The Commerce Control List No. Supplement No. 1 to Part 774 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE EXPORT ADMINISTRATION REGULATIONS THE COMMERCE CONTROL LIST Pt. 774, Supp. No. 1...

15 CFR Supplement No. 1 to Part 774 - The Commerce Control List

Code of Federal Regulations, 2010 CFR

2016-01-01

... 15 Commerce and Foreign Trade 2 2016-01-01 2016-01-01 false The Commerce Control List No. Supplement No. 1 to Part 774 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE EXPORT ADMINISTRATION REGULATIONS THE COMMERCE CONTROL LIST Pt. 774, Supp. No. 1...

15 CFR Supplement No. 1 to Part 774 - The Commerce Control List

Code of Federal Regulations, 2010 CFR

2018-01-01

... 15 Commerce and Foreign Trade 2 2018-01-01 2018-01-01 false The Commerce Control List No. Supplement No. 1 to Part 774 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE EXPORT ADMINISTRATION REGULATIONS THE COMMERCE CONTROL LIST Pt. 774, Supp. No. 1...

A Herpesvirus Protein Selectively Inhibits Cellular mRNA Nuclear Export.

PubMed

Gong, Danyang; Kim, Yong Hoon; Xiao, Yuchen; Du, Yushen; Xie, Yafang; Lee, Kevin K; Feng, Jun; Farhat, Nisar; Zhao, Dawei; Shu, Sara; Dai, Xinghong; Chanda, Sumit K; Rana, Tariq M; Krogan, Nevan J; Sun, Ren; Wu, Ting-Ting

2016-11-09

Nuclear mRNA export is highly regulated to ensure accurate cellular gene expression. Viral inhibition of cellular mRNA export can enhance viral access to the cellular translation machinery and prevent anti-viral protein production but is generally thought to be nonselective. We report that ORF10 of Kaposi's sarcoma-associated herpesvirus (KSHV), a nuclear DNA virus, inhibits mRNA export in a transcript-selective manner to control cellular gene expression. Nuclear export inhibition by ORF10 requires an interaction with an RNA export factor, Rae1. Genome-wide analysis reveals a subset of cellular mRNAs whose nuclear export is blocked by ORF10 with the 3' UTRs of ORF10-targeted transcripts conferring sensitivity to export inhibition. The ORF10-Rae1 interaction is important for the virus to express viral genes and produce infectious virions. These results suggest that a nuclear DNA virus can selectively interfere with RNA export to restrict host gene expression for optimal replication. Published by Elsevier Inc.

75 FR 1020 - Amendments to the Export Administration Regulations (EAR) Based Upon the Accession of Albania and...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-08

...--Commerce Country Chart [Reason for control] Countries Chemical & biological Nuclear National Security Missile Regional Stability Firearms Crime control Anti-terrorism weapons nonproliferation Tech convention...

22 CFR 91.1 - Answering inquiries regarding tariff acts and customs regulations.

Code of Federal Regulations, 2012 CFR

2012-04-01

... customs regulations. 91.1 Section 91.1 Foreign Relations DEPARTMENT OF STATE LEGAL AND RELATED SERVICES IMPORT CONTROLS § 91.1 Answering inquiries regarding tariff acts and customs regulations. In replying to inquiries received from exporters, travelers, or other interested parties, concerning tariff acts or customs...

22 CFR 91.1 - Answering inquiries regarding tariff acts and customs regulations.

Code of Federal Regulations, 2014 CFR

2014-04-01

... customs regulations. 91.1 Section 91.1 Foreign Relations DEPARTMENT OF STATE LEGAL AND RELATED SERVICES IMPORT CONTROLS § 91.1 Answering inquiries regarding tariff acts and customs regulations. In replying to inquiries received from exporters, travelers, or other interested parties, concerning tariff acts or customs...

22 CFR 91.1 - Answering inquiries regarding tariff acts and customs regulations.

Code of Federal Regulations, 2013 CFR

2013-04-01

... customs regulations. 91.1 Section 91.1 Foreign Relations DEPARTMENT OF STATE LEGAL AND RELATED SERVICES IMPORT CONTROLS § 91.1 Answering inquiries regarding tariff acts and customs regulations. In replying to inquiries received from exporters, travelers, or other interested parties, concerning tariff acts or customs...

22 CFR 91.1 - Answering inquiries regarding tariff acts and customs regulations.

Code of Federal Regulations, 2011 CFR

2011-04-01

... customs regulations. 91.1 Section 91.1 Foreign Relations DEPARTMENT OF STATE LEGAL AND RELATED SERVICES IMPORT CONTROLS § 91.1 Answering inquiries regarding tariff acts and customs regulations. In replying to inquiries received from exporters, travelers, or other interested parties, concerning tariff acts or customs...

22 CFR 91.1 - Answering inquiries regarding tariff acts and customs regulations.

Code of Federal Regulations, 2010 CFR

2010-04-01

... customs regulations. 91.1 Section 91.1 Foreign Relations DEPARTMENT OF STATE LEGAL AND RELATED SERVICES IMPORT CONTROLS § 91.1 Answering inquiries regarding tariff acts and customs regulations. In replying to inquiries received from exporters, travelers, or other interested parties, concerning tariff acts or customs...

22 CFR 120.5 - Relation to regulations of other agencies.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 22 Foreign Relations 1 2014-04-01 2014-04-01 false Relation to regulations of other agencies. 120.5 Section 120.5 Foreign Relations DEPARTMENT OF STATE INTERNATIONAL TRAFFIC IN ARMS REGULATIONS... General collectively comprise the U.S. Munitions List under the Arms Export Control Act (AECA). As the...

Impacts of the Doha Round framework agreements on dairy policies.

PubMed

Suzuki, N; Kaiser, H M

2005-05-01

Dairy is highly regulated in many countries for several reasons. Perishability, seasonal imbalances, and inelastic supply and demand for milk can cause inherent market instability. Milk buyers typically have had more market power than dairy farmers. Comparative production advantages in some countries have led to regulations and policies to protect local dairy farmers by maintaining domestic prices higher than world prices. A worldwide consensus on reduction of border measures for protecting dairy products is unlikely, and dairy will probably be an exception in ongoing World Trade Organization (WTO) negotiations. Under the Doha Round framework agreements, countries may name some products such as dairy as "sensitive," thereby excluding them from further reforms. However, new Doha Round framework agreements depart from the current WTO rule and call for product-specific spending caps. Such caps will greatly affect the dairy sector because dairy accounts for much of the aggregate measure of support (AMS) in several countries, including the United States and Canada. Also, the amounts of dairy AMS in several countries may be recalculated relative to an international reference price. In addition, all export subsidies are targeted for elimination in the Doha Round, including export credit programs and state trading enterprises, which will limit options for disposing of surplus dairy products in foreign markets. Currently, with higher domestic prices, measures for cutting or disposing of surpluses have been used in many countries. Supply control, which is not regulated by WTO rules, remains as an option. Although explicit export subsidies are restricted by WTO rules, many countries use esoteric measures to promote dairy exports. If countries agree to eliminate "consumer financed" export subsidies using a theoretical definition and measurements proposed herein as Export Subsidy Equivalents (ESE), dairy exports in many countries may be affected. Although domestic supports and export subsidies will be reduced in the Doha Round, possible exclusion of "sensitive" products from tariff reduction will help some countries' dairy sectors survive after those final agreements. A key concern for those countries will be the simultaneous restriction of surplus-disposing measures. With fewer marketing options for surpluses, countries that continue border protection and high internal prices will likely be forced to use domestic supply control programs in the future.

Sierra/SolidMechanics 4.48 User's Guide: Addendum for Shock Capabilities.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Plews, Julia A.; Crane, Nathan K; de Frias, Gabriel Jose

This is an addendum to the Sierra/SolidMechanics 4.48 User's Guide that documents additional capabilities available only in alternate versions of the Sierra/SolidMechanics (Sierra/SM) code. These alternate versions are enhanced to provide capabilities that are regulated under the U.S. Department of State's International Traffic in Arms Regulations (ITAR) export-control rules. The ITAR regulated codes are only distributed to entities that comply with the ITAR export-control requirements. The ITAR enhancements to Sierra/SM in- clude material models with an energy-dependent pressure response (appropriate for very large deformations and strain rates) and capabilities for blast modeling. Since this is an addendum to the standardmore » Sierra/SM user's guide, please refer to that document first for general descriptions of code capability and use.« less

50 CFR 300.183 - Permit holder reporting and recordkeeping requirements.

Code of Federal Regulations, 2012 CFR

2012-10-01

... biweekly report of entries for consumption, exports and re-exports of fish and fish products regulated... products regulated under this subpart except shark fins were entered for consumption, exported, or re..., that is entered for consumption, exported, or re-exported. (3) A biweekly report is not required for...

50 CFR 300.183 - Permit holder reporting and recordkeeping requirements.

Code of Federal Regulations, 2013 CFR

2013-10-01

... biweekly report of entries for consumption, exports and re-exports of fish and fish products regulated... products regulated under this subpart except shark fins were entered for consumption, exported, or re..., that is entered for consumption, exported, or re-exported. (3) A biweekly report is not required for...

50 CFR 300.183 - Permit holder reporting and recordkeeping requirements.

Code of Federal Regulations, 2014 CFR

2014-10-01

... biweekly report of entries for consumption, exports and re-exports of fish and fish products regulated... products regulated under this subpart except shark fins were entered for consumption, exported, or re..., that is entered for consumption, exported, or re-exported. (3) A biweekly report is not required for...

76 FR 76097 - Amendment to the International Traffic in Arms Regulations: Establishment of U.S. Munitions List...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-06

...As part of the President's Export Control Reform effort, the Department of State proposes to amend the International Traffic in Arms Regulations (ITAR) to establish Category XIX of the U.S. Munitions List (USML) to describe gas turbine engines and associated equipment warranting control on the USML.

15 CFR Supplement No. 4 to Part 744 - Entity List

Code of Federal Regulations, 2012 CFR

2012-01-01

...) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE EXPORT ADMINISTRATION REGULATIONS CONTROL POLICY... Beijing; —Institute of Control Devices (BICD); —Beijing Institute of Aerospace Control Devices (BIACD); —Beijing Aerospace Control Instruments Institute; and —Design and Manufacture Center of Navigation and...

22 CFR 120.42 - Subject to the Export Administration Regulations (EAR).

Code of Federal Regulations, 2014 CFR

2014-04-01

... 22 Foreign Relations 1 2014-04-01 2014-04-01 false Subject to the Export Administration Regulations (EAR). 120.42 Section 120.42 Foreign Relations DEPARTMENT OF STATE INTERNATIONAL TRAFFIC IN ARMS REGULATIONS PURPOSE AND DEFINITIONS § 120.42 Subject to the Export Administration Regulations (EAR). Items...

22 CFR 120.25 - Empowered Official.

Code of Federal Regulations, 2011 CFR

2011-04-01

... Foreign Relations DEPARTMENT OF STATE INTERNATIONAL TRAFFIC IN ARMS REGULATIONS PURPOSE AND DEFINITIONS... liability and administrative penalties for violating the Arms Export Control Act and the International Traffic in Arms Regulations; and (4) Has the independent authority to: (i) Enquire into any aspect of a...

22 CFR 120.25 - Empowered Official.

Code of Federal Regulations, 2014 CFR

2014-04-01

... Foreign Relations DEPARTMENT OF STATE INTERNATIONAL TRAFFIC IN ARMS REGULATIONS PURPOSE AND DEFINITIONS... liability and administrative penalties for violating the Arms Export Control Act and the International Traffic in Arms Regulations; and (4) Has the independent authority to: (i) Inquire into any aspect of a...

22 CFR 120.25 - Empowered Official.

Code of Federal Regulations, 2012 CFR

2012-04-01

... Foreign Relations DEPARTMENT OF STATE INTERNATIONAL TRAFFIC IN ARMS REGULATIONS PURPOSE AND DEFINITIONS... liability and administrative penalties for violating the Arms Export Control Act and the International Traffic in Arms Regulations; and (4) Has the independent authority to: (i) Enquire into any aspect of a...

22 CFR 120.25 - Empowered Official.

Code of Federal Regulations, 2010 CFR

2010-04-01

... Foreign Relations DEPARTMENT OF STATE INTERNATIONAL TRAFFIC IN ARMS REGULATIONS PURPOSE AND DEFINITIONS... liability and administrative penalties for violating the Arms Export Control Act and the International Traffic in Arms Regulations; and (4) Has the independent authority to: (i) Enquire into any aspect of a...

22 CFR 120.25 - Empowered Official.

Code of Federal Regulations, 2013 CFR

2013-04-01

... Foreign Relations DEPARTMENT OF STATE INTERNATIONAL TRAFFIC IN ARMS REGULATIONS PURPOSE AND DEFINITIONS... liability and administrative penalties for violating the Arms Export Control Act and the International Traffic in Arms Regulations; and (4) Has the independent authority to: (i) Enquire into any aspect of a...

15 CFR 738.1 - Introduction.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 15 Commerce and Foreign Trade 2 2011-01-01 2011-01-01 false Introduction. 738.1 Section 738.1 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE EXPORT ADMINISTRATION REGULATIONS COMMERCE CONTROL LIST...

15 CFR 738.1 - Introduction.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 15 Commerce and Foreign Trade 2 2013-01-01 2013-01-01 false Introduction. 738.1 Section 738.1 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE EXPORT ADMINISTRATION REGULATIONS COMMERCE CONTROL LIST...

15 CFR 738.1 - Introduction.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 15 Commerce and Foreign Trade 2 2014-01-01 2014-01-01 false Introduction. 738.1 Section 738.1 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE EXPORT ADMINISTRATION REGULATIONS COMMERCE CONTROL LIST...

15 CFR 738.1 - Introduction.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 15 Commerce and Foreign Trade 2 2012-01-01 2012-01-01 false Introduction. 738.1 Section 738.1 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE EXPORT ADMINISTRATION REGULATIONS COMMERCE CONTROL LIST...

15 CFR 738.1 - Introduction.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 15 Commerce and Foreign Trade 2 2010-01-01 2010-01-01 false Introduction. 738.1 Section 738.1 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE EXPORT ADMINISTRATION REGULATIONS COMMERCE CONTROL LIST...

78 FR 31431 - Export Administration Regulations (EAR): Control of Spacecraft Systems and Related Items the...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-24

.... Paragraph 9A515.b would control ground control systems and training simulators ``specially designed'' for.... Paragraph .d would control certain radiation hardened microelectronic circuits that are ``specially designed... .a would control test, inspection, and production ``equipment'' ``specially designed'' for the...

15 CFR 742.7 - Crime control.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 15 Commerce and Foreign Trade 2 2010-01-01 2010-01-01 false Crime control. 742.7 Section 742.7... INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE EXPORT ADMINISTRATION REGULATIONS CONTROL POLICY-CCL BASED CONTROLS § 742.7 Crime control. (a) License requirements. In support of U.S. foreign policy to promote the...

31 CFR 545.527 - Diplomatic pouches.

Code of Federal Regulations, 2010 CFR

2010-07-01

... FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY TALIBAN (AFGHANISTAN) SANCTIONS REGULATIONS Licenses... with the importation into the United States from the territory of Afghanistan controlled by the Taliban, or the exportation from the United States to the territory of Afghanistan controlled by the Taliban...

Regulation of the Expression of Bacterial Multidrug Exporters by Two-Component Signal Transduction Systems.

PubMed

Nishino, Kunihiko

2018-01-01

Bacterial multidrug exporters confer resistance to a wide range of antibiotics, dyes, and biocides. Recent studies have shown that there are many multidrug exporters encoded in bacterial genome. For example, it was experimentally identified that E. coli has at least 20 multidrug exporters. Because many of these multidrug exporters have overlapping substrate spectra, it is intriguing that bacteria, with their economically organized genomes, harbor such large sets of multidrug exporter genes. The key to understanding how bacteria utilize these multiple exporters lies in the regulation of exporter expression. Bacteria have developed signaling systems for eliciting a variety of adaptive responses to their environments. These adaptive responses are often mediated by two-component regulatory systems. In this chapter, the method to identify response regulators that affect expression of multidrug exporters is described.

Function of the conserved FHIPEP domain of the flagellar type III export apparatus, protein FlhA.

PubMed

Barker, Clive S; Inoue, Tomoharu; Meshcheryakova, Irina V; Kitanobo, Seiya; Samatey, Fadel A

2016-04-01

The Type III flagellar protein export apparatus of bacteria consists of five or six membrane proteins, notably FlhA, which controls the export of other proteins and is homologous to the large family of FHIPEP export proteins. FHIPEP proteins contain a highly-conserved cytoplasmic domain. We mutagenized the cloned Salmonella flhA gene for the 692 amino acid FlhA, changing a single, conserved amino acid in the 68-amino acid FHIPEP region. Fifty-two mutations at 30 positions mostly led to loss of motility and total disappearance of microscopically visible flagella, also Western blot protein/protein hybridization showed no detectable export of hook protein and flagellin. There were two exceptions: a D199A mutant strain, which produced short-stubby flagella; and a V151L mutant strain, which did not produce flagella and excreted mainly un-polymerized hook protein. The V151L mutant strain also exported a reduced amount of hook-cap protein FlgD, but when grown with exogenous FlgD it produced polyhooks and polyhook-filaments. A suppressor mutant in the cytoplasmic domain of the export apparatus membrane protein FlhB rescued export of hook-length control protein FliK and facilitated growth of full-length flagella. These results suggested that the FHIPEP region is part of the gate regulating substrate entry into the export apparatus pore. © 2015 John Wiley & Sons Ltd.

7 CFR 922.15 - Export.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 8 2010-01-01 2010-01-01 false Export. 922.15 Section 922.15 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and... WASHINGTON Order Regulating Handling Definitions § 922.15 Export. Export means to ship apricots beyond the...

7 CFR 948.17 - Export.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 8 2010-01-01 2010-01-01 false Export. 948.17 Section 948.17 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and... Regulating Handling Definitions § 948.17 Export. Export means the shipment of potatoes to any destination...

7 CFR 923.15 - Export.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 8 2010-01-01 2010-01-01 false Export. 923.15 Section 923.15 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and... IN WASHINGTON Order Regulating Handling Definitions § 923.15 Export. Export means to ship cherries...

7 CFR 924.15 - Export.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 8 2010-01-01 2010-01-01 false Export. 924.15 Section 924.15 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and... WASHINGTON AND IN UMATILLA COUNTY, OREGON Order Regulating Handling Definitions § 924.15 Export. Export means...

7 CFR 946.15 - Export.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 8 2010-01-01 2010-01-01 false Export. 946.15 Section 946.15 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and... Regulating Handling Definitions § 946.15 Export. Export means shipment of potatoes beyond the boundaries of...

7 CFR 958.14 - Export.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 8 2010-01-01 2010-01-01 false Export. 958.14 Section 958.14 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and... IN IDAHO, AND MALHEUR COUNTY, OREGON Order Regulating Handling Definitions § 958.14 Export. Export...

7 CFR 945.14 - Export.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 8 2010-01-01 2010-01-01 false Export. 945.14 Section 945.14 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and... COUNTIES IN IDAHO, AND MALHEUR COUNTY, OREGON Order Regulating Handling Definitions § 945.14 Export. Export...

7 CFR 927.12 - Export market.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 8 2010-01-01 2010-01-01 false Export market. 927.12 Section 927.12 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements... Order Regulating Handling Definitions § 927.12 Export market. Export market means any destination which...

p35 Regulates the CRM1-Dependent Nucleocytoplasmic Shuttling of Nuclear Hormone Receptor Coregulator-Interacting Factor 1 (NIF-1)

PubMed Central

Zhao, Xiao-Su; Fu, Wing-Yu; Chien, Winnie W. Y.; Li, Zhen; Fu, Amy K. Y.; Ip, Nancy Y.

2014-01-01

Cyclin-dependent kinase 5 (Cdk5) is a proline-directed serine/threonine kinase, which plays critical roles in a wide spectrum of neuronal functions including neuronal survival, neurite outgrowth, and synapse development and plasticity. Cdk5 activity is controlled by its specific activators: p35 or p39. While knockout studies reveal that Cdk5/p35 is critical for neuronal migration during early brain development, functions of Cdk5/p35 have been unraveled through the identification of the interacting proteins of p35, most of which are Cdk5/p35 substrates. However, it remains unclear whether p35 can regulate neuronal functions independent of Cdk5 activity. Here, we report that a nuclear protein, nuclear hormone receptor coregulator (NRC)-interacting factor 1 (NIF-1), is a new interacting partner of p35. Interestingly, p35 regulates the functions of NIF-1 independent of Cdk5 activity. NIF-1 was initially discovered as a transcriptional regulator that enhances the transcriptional activity of nuclear hormone receptors. Our results show that p35 interacts with NIF-1 and regulates its nucleocytoplasmic trafficking via the nuclear export pathway. Furthermore, we identified a nuclear export signal on p35; mutation of this site or blockade of the CRM1/exportin-dependent nuclear export pathway resulted in the nuclear accumulation of p35. Intriguingly, blocking the nuclear export of p35 attenuated the nuclear accumulation of NIF-1. These findings reveal a new p35-dependent mechanism in transcriptional regulation that involves the nucleocytoplasmic shuttling of transcription regulators. PMID:25329792

p35 regulates the CRM1-dependent nucleocytoplasmic shuttling of nuclear hormone receptor coregulator-interacting factor 1 (NIF-1).

PubMed

Zhao, Xiao-Su; Fu, Wing-Yu; Chien, Winnie W Y; Li, Zhen; Fu, Amy K Y; Ip, Nancy Y

2014-01-01

Cyclin-dependent kinase 5 (Cdk5) is a proline-directed serine/threonine kinase, which plays critical roles in a wide spectrum of neuronal functions including neuronal survival, neurite outgrowth, and synapse development and plasticity. Cdk5 activity is controlled by its specific activators: p35 or p39. While knockout studies reveal that Cdk5/p35 is critical for neuronal migration during early brain development, functions of Cdk5/p35 have been unraveled through the identification of the interacting proteins of p35, most of which are Cdk5/p35 substrates. However, it remains unclear whether p35 can regulate neuronal functions independent of Cdk5 activity. Here, we report that a nuclear protein, nuclear hormone receptor coregulator (NRC)-interacting factor 1 (NIF-1), is a new interacting partner of p35. Interestingly, p35 regulates the functions of NIF-1 independent of Cdk5 activity. NIF-1 was initially discovered as a transcriptional regulator that enhances the transcriptional activity of nuclear hormone receptors. Our results show that p35 interacts with NIF-1 and regulates its nucleocytoplasmic trafficking via the nuclear export pathway. Furthermore, we identified a nuclear export signal on p35; mutation of this site or blockade of the CRM1/exportin-dependent nuclear export pathway resulted in the nuclear accumulation of p35. Intriguingly, blocking the nuclear export of p35 attenuated the nuclear accumulation of NIF-1. These findings reveal a new p35-dependent mechanism in transcriptional regulation that involves the nucleocytoplasmic shuttling of transcription regulators.

77 FR 25133 - Order Temporarily Denying Export Privileges

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-27

... DEPARTMENT OF COMMERCE Bureau of Industry and Security Order Temporarily Denying Export Privileges... Section 766.24 of the Export Administration Regulations (``EAR'' or the ``Regulations''),\\1\\ the Bureau of Industry and Security (``BIS''), U.S. Department of Commerce, through its Office of Export Enforcement...

7 CFR 915.12 - Export.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 8 2010-01-01 2010-01-01 false Export. 915.12 Section 915.12 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and... Regulating Handling Definitions § 915.12 Export. Export means to ship avocados to any destination which is...

15 CFR 772.1 - Definitions of terms as used in the Export Administration Regulations (EAR).

Code of Federal Regulations, 2011 CFR

2011-01-01

... instructions include replacement of fixed storage devices, but not a physical change in wiring or... digital electronic control system for a gas turbine engine that is able to autonomously control the engine...

PI3K class II α regulates δ-opioid receptor export from the trans-Golgi network.

PubMed

Shiwarski, Daniel J; Darr, Marlena; Telmer, Cheryl A; Bruchez, Marcel P; Puthenveedu, Manojkumar A

2017-08-01

The interplay between signaling and trafficking by G protein-coupled receptors (GPCRs) has focused mainly on endocytic trafficking. Whether and how surface delivery of newly synthesized GPCRs is regulated by extracellular signals is less understood. Here we define a signaling-regulated checkpoint at the trans -Golgi network (TGN) that controls the surface delivery of the delta opioid receptor (δR). In PC12 cells, inhibition of phosphoinositide-3 kinase (PI3K) activity blocked export of newly synthesized δR from the Golgi and delivery to the cell surface, similar to treatment with nerve growth factor (NGF). Depletion of class II phosphoinositide-3 kinase α (PI3K C2A), but not inhibition of class I PI3K, blocked δR export to comparable levels and attenuated δR-mediated cAMP inhibition. NGF treatment displaced PI3K C2A from the Golgi and optogenetic recruitment of the PI3K C2A kinase domain to the TGN-induced δR export downstream of NGF. Of importance, PI3K C2A expression promotes export of endogenous δR in primary trigeminal ganglion neurons. Taken together, our results identify PI3K C2A as being required and sufficient for δR export and surface delivery in neuronal cells and suggest that it could be a key modulator of a novel Golgi export checkpoint that coordinates GPCR delivery to the surface. © 2017 Shiwarski et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

ExportAid: database of RNA elements regulating nuclear RNA export in mammals.

PubMed

Giulietti, Matteo; Milantoni, Sara Armida; Armeni, Tatiana; Principato, Giovanni; Piva, Francesco

2015-01-15

Regulation of nuclear mRNA export or retention is carried out by RNA elements but the mechanism is not yet well understood. To understand the mRNA export process, it is important to collect all the involved RNA elements and their trans-acting factors. By hand-curated literature screening we collected, in ExportAid database, experimentally assessed data about RNA elements regulating nuclear export or retention of endogenous, heterologous or artificial RNAs in mammalian cells. This database could help to understand the RNA export language and to study the possible export efficiency alterations owing to mutations or polymorphisms. Currently, ExportAid stores 235 and 96 RNA elements, respectively, increasing and decreasing export efficiency, and 98 neutral assessed sequences. Freely accessible without registration at http://www.introni.it/ExportAid/ExportAid.html. Database and web interface are implemented in Perl, MySQL, Apache and JavaScript with all major browsers supported. © The Author 2014. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

31 CFR 541.206 - Exempt transactions.

Code of Federal Regulations, 2010 CFR

2010-07-01

... country and the exportation to any country of information or informational materials, as defined in § 541... regulation or authorize transactions incident to the exportation of software subject to the Export Administration Regulations, 15 CFR parts 730-774, or to the exportation of goods, technology or software, or to...

31 CFR 542.206 - Exempt transactions.

Code of Federal Regulations, 2012 CFR

2012-07-01

... country and the exportation to any country of information or informational materials, as defined in § 542... regulation or authorize transactions incident to the exportation of software subject to the Export Administration Regulations, 15 CFR parts 730 through 799, or to the exportation of goods, technology or software...

31 CFR 542.206 - Exempt transactions.

Code of Federal Regulations, 2011 CFR

2011-07-01

... country and the exportation to any country of information or informational materials, as defined in § 542... regulation or authorize transactions incident to the exportation of software subject to the Export Administration Regulations, 15 CFR parts 730 through 799, or to the exportation of goods, technology or software...

31 CFR 541.206 - Exempt transactions.

Code of Federal Regulations, 2012 CFR

2012-07-01

... country and the exportation to any country of information or informational materials, as defined in § 541... regulation or authorize transactions incident to the exportation of software subject to the Export Administration Regulations, 15 CFR parts 730-774, or to the exportation of goods, technology or software, or to...

31 CFR 541.206 - Exempt transactions.

Code of Federal Regulations, 2014 CFR

2014-07-01

... country and the exportation to any country of information or informational materials, as defined in § 541... regulation or authorize transactions incident to the exportation of software subject to the Export Administration Regulations, 15 CFR parts 730-774, or to the exportation of goods, technology or software, or to...

31 CFR 541.206 - Exempt transactions.

Code of Federal Regulations, 2011 CFR

2011-07-01

... country and the exportation to any country of information or informational materials, as defined in § 541... regulation or authorize transactions incident to the exportation of software subject to the Export Administration Regulations, 15 CFR parts 730-774, or to the exportation of goods, technology or software, or to...

31 CFR 542.206 - Exempt transactions.

Code of Federal Regulations, 2013 CFR

2013-07-01

... country and the exportation to any country of information or informational materials, as defined in § 542... regulation or authorize transactions incident to the exportation of software subject to the Export Administration Regulations, 15 CFR parts 730 through 799, or to the exportation of goods, technology or software...

31 CFR 541.206 - Exempt transactions.

Code of Federal Regulations, 2013 CFR

2013-07-01

... country and the exportation to any country of information or informational materials, as defined in § 541... regulation or authorize transactions incident to the exportation of software subject to the Export Administration Regulations, 15 CFR parts 730-774, or to the exportation of goods, technology or software, or to...

31 CFR 542.206 - Exempt transactions.

Code of Federal Regulations, 2010 CFR

2010-07-01

... country and the exportation to any country of information or informational materials, as defined in § 542... regulation or authorize transactions incident to the exportation of software subject to the Export Administration Regulations, 15 CFR parts 730 through 799, or to the exportation of goods, technology or software...

Inspection report: the Department of Energy's export licensing process for dual-use and munitions commodities

DOE Office of Scientific and Technical Information (OSTI.GOV)

Friedman, Gregory H.

1999-05-01

Export of commodities, encouraged by both the private sector and the Federal Government, helps to improve our position in the global economy and is in the national interest of the US. However, exports of commodities or technologies, without regard to whether they may significantly contribute to the military potential of individual countries or combination of countries or enhance the proliferation of weapons of mass destruction, may adversely affect the national security of the US. The Federal Government, therefore, implements several laws, Executive Orders, and regulations to control the export of certain commodities and technologies. These commodities and technologies require amore » license for export. Some of the controlled items are designated as ''dual-use,'' that is, commodities and technologies that have both civilian and military application. Some dual-use commodities are designated as ''nuclear dual-use''--items controlled for nuclear nonproliferation purposes. Another group of controlled commodities is designated as munitions, which are goods and technologies that have solely military uses. The Department of Energy (Energy) conducts reviews of export license applications for nuclear dual-use items and certain munitions. On August 26, 1998, the Chairman of the Senate Committee on Governmental Affairs requested that the Inspectors General from the Departments of Commerce, Defense, Energy, State, and Treasury, and the Central Intelligence Agency (CIA), update and expand on a 1993 interagency review conducted by the Inspectors General of the Departments of Commerce, Defense, Energy, and State of the export licensing processes for dual-use and munitions commodities.« less

15 CFR 770.2 - Item interpretations.

Code of Federal Regulations, 2012 CFR

2012-01-01

... OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE EXPORT ADMINISTRATION REGULATIONS INTERPRETATIONS.... “Numerical control” units include computers with add-on “motion control boards”. A computer with add-on “motion control boards” for machine tools may be controlled under ECCN 2B001.a even when the computer...

15 CFR 770.2 - Item interpretations.

Code of Federal Regulations, 2013 CFR

2013-01-01

... OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE EXPORT ADMINISTRATION REGULATIONS INTERPRETATIONS.... “Numerical control” units include computers with add-on “motion control boards”. A computer with add-on “motion control boards” for machine tools may be controlled under ECCN 2B001.a even when the computer...

15 CFR 770.2 - Item interpretations.

Code of Federal Regulations, 2014 CFR

2014-01-01

... OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE EXPORT ADMINISTRATION REGULATIONS INTERPRETATIONS.... “Numerical control” units include computers with add-on “motion control boards”. A computer with add-on “motion control boards” for machine tools may be controlled under ECCN 2B001.a even when the computer...

78 FR 13463 - Editorial Corrections to the Export Administration Regulations

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-28

... typographical and formatting errors in the title of the Information Collection under OMB Control Number 0694... Monitoring Or Controls On Recyclable Metallic Materials; Public Hearings'' to remove extraneous quotation... the EAR with the correct contact information for the Directorate of Defense Trade Controls. More...

15 CFR 772.1 - Definitions of terms as used in the Export Administration Regulations (EAR).

Code of Federal Regulations, 2010 CFR

2003-01-01

... 15 Commerce and Foreign Trade 2 2003-01-01 2003-01-01 false Definitions of terms as used in the Export Administration Regulations (EAR). 772.1 Section 772.1 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE EXPORT ADMINISTRATION REGULATIONS DEFINITION...

15 CFR 772.1 - Definitions of terms as used in the Export Administration Regulations (EAR).

Code of Federal Regulations, 2010 CFR

2008-01-01

... 15 Commerce and Foreign Trade 2 2008-01-01 2008-01-01 false Definitions of terms as used in the Export Administration Regulations (EAR). 772.1 Section 772.1 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE EXPORT ADMINISTRATION REGULATIONS DEFINITION...

15 CFR 772.1 - Definitions of terms as used in the Export Administration Regulations (EAR).

Code of Federal Regulations, 2010 CFR

2004-01-01

... 15 Commerce and Foreign Trade 2 2004-01-01 2004-01-01 false Definitions of terms as used in the Export Administration Regulations (EAR). 772.1 Section 772.1 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE EXPORT ADMINISTRATION REGULATIONS DEFINITION...

15 CFR 772.1 - Definitions of terms as used in the Export Administration Regulations (EAR).

Code of Federal Regulations, 2010 CFR

2005-01-01

... 15 Commerce and Foreign Trade 2 2005-01-01 2005-01-01 false Definitions of terms as used in the Export Administration Regulations (EAR). 772.1 Section 772.1 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE EXPORT ADMINISTRATION REGULATIONS DEFINITION...

15 CFR 772.1 - Definitions of terms as used in the Export Administration Regulations (EAR).

Code of Federal Regulations, 2010 CFR

2007-01-01

... 15 Commerce and Foreign Trade 2 2007-01-01 2007-01-01 false Definitions of terms as used in the Export Administration Regulations (EAR). 772.1 Section 772.1 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE EXPORT ADMINISTRATION REGULATIONS DEFINITION...

15 CFR 772.1 - Definitions of terms as used in the Export Administration Regulations (EAR).

Code of Federal Regulations, 2010 CFR

2006-01-01

... 15 Commerce and Foreign Trade 2 2006-01-01 2006-01-01 false Definitions of terms as used in the Export Administration Regulations (EAR). 772.1 Section 772.1 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE EXPORT ADMINISTRATION REGULATIONS DEFINITION...

15 CFR 772.1 - Definitions of terms as used in the Export Administration Regulations (EAR).

Code of Federal Regulations, 2010 CFR

2009-01-01

... 15 Commerce and Foreign Trade 2 2009-01-01 2009-01-01 false Definitions of terms as used in the Export Administration Regulations (EAR). 772.1 Section 772.1 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE EXPORT ADMINISTRATION REGULATIONS DEFINITION...

15 CFR 772.1 - Definitions of terms as used in the Export Administration Regulations (EAR).

Code of Federal Regulations, 2014 CFR

2014-01-01

... 15 Commerce and Foreign Trade 2 2014-01-01 2014-01-01 false Definitions of terms as used in the Export Administration Regulations (EAR). 772.1 Section 772.1 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE EXPORT ADMINISTRATION REGULATIONS DEFINITION...

15 CFR 772.1 - Definitions of terms as used in the Export Administration Regulations (EAR).

Code of Federal Regulations, 2012 CFR

2012-01-01

... 15 Commerce and Foreign Trade 2 2012-01-01 2012-01-01 false Definitions of terms as used in the Export Administration Regulations (EAR). 772.1 Section 772.1 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE EXPORT ADMINISTRATION REGULATIONS DEFINITION...

15 CFR 772.1 - Definitions of terms as used in the Export Administration Regulations (EAR).

Code of Federal Regulations, 2013 CFR

2013-01-01

... 15 Commerce and Foreign Trade 2 2013-01-01 2013-01-01 false Definitions of terms as used in the Export Administration Regulations (EAR). 772.1 Section 772.1 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE EXPORT ADMINISTRATION REGULATIONS DEFINITION...

Amounts, isotopic character, and ages of organic and inorganic carbon exported from rivers to ocean margins: 2. Assessment of natural and anthropogenic controls

NASA Astrophysics Data System (ADS)

Hossler, Katie; Bauer, James E.

2013-04-01

Riverine exports of carbon (C) and organic matter (OM) are regulated by a variety of natural and anthropogenic factors. Understanding the relationships between these various factors and C and OM exports can help to constrain global C budgets and allow assessment of current and future anthropogenic impacts on both riverine and global C cycles. We quantified the effects of multiple natural and anthropogenic controls on riverine export fluxes and compositions of particulate organic C, dissolved organic C, and dissolved inorganic C for a regional group of eight rivers in the northeastern U.S. Potential controls related to hydrogeomorphology and regional climate, soil order, soil texture, bedrock lithology, land use, and anthropogenic factors were analyzed individually, collectively, and at scales of both local and regional influence. Factors related to hydrogeomorphology and climate, followed in importance by land use and anthropogenic factors, exhibited the strongest impacts on riverine C exports and compositions, particularly at smaller localized scales. The effects of hydrogeomorphology and climate were primarily related to volumetric flow, which resulted in greater exports of terrestrial and total C. Principal anthropogenic factors included impacts of wastewater treatment plants (WWTPs) and river impoundments. The presence of WWTPs as well as anthropogenic use of carbonate-based materials (e.g., limestone) may have substantially increased riverine C exports, particularly fossil C exports, in the study region. The presence of nuclear power plants in the associated watersheds is also discussed because of the potential for anthropogenic 14C inputs and subsequent biasing of aquatic C studies utilizing natural abundance 14C.

15 CFR 732.5 - Steps regarding Shipper's Export Declaration or Automated Export System record, Destination...

Code of Federal Regulations, 2010 CFR

2010-01-01

... 15 Commerce and Foreign Trade 2 2010-01-01 2010-01-01 false Steps regarding Shipper's Export... Section 732.5 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE EXPORT ADMINISTRATION REGULATIONS STEPS FOR USING...

15 CFR 30.15 - Introduction.

Code of Federal Regulations, 2010 CFR

2010-01-01

... Introduction. (a) For export shipments to foreign countries, the EEI is used both for statistical and for... 15 Commerce and Foreign Trade 1 2010-01-01 2010-01-01 false Introduction. 30.15 Section 30.15... control regulations, as well as the requirements of the statistical regulations of this part. For...

Protein kinase A is part of a mechanism that regulates nuclear reimport of the nuclear tRNA export receptors Los1p and Msn5p.

PubMed

Pierce, Jacqueline B; van der Merwe, George; Mangroo, Dev

2014-02-01

The two main signal transduction mechanisms that allow eukaryotes to sense and respond to changes in glucose availability in the environment are the cyclic AMP (cAMP)/protein kinase A (PKA) and AMP-activated protein kinase (AMPK)/Snf1 kinase-dependent pathways. Previous studies have shown that the nuclear tRNA export process is inhibited in Saccharomyces cerevisiae deprived of glucose. However, the signal transduction pathway involved and the mechanism by which glucose availability regulates nuclear-cytoplasmic tRNA trafficking are not understood. Here, we show that inhibition of nuclear tRNA export is caused by a block in nuclear reimport of the tRNA export receptors during glucose deprivation. Cytoplasmic accumulation of the tRNA export receptors during glucose deprivation is not caused by activation of Snf1p. Evidence obtained suggests that PKA is part of the mechanism that regulates nuclear reimport of the tRNA export receptors in response to glucose availability. This mechanism does not appear to involve phosphorylation of the nuclear tRNA export receptors by PKA. The block in nuclear reimport of the tRNA export receptors appears to be caused by activation of an unidentified mechanism when PKA is turned off during glucose deprivation. Taken together, the data suggest that PKA facilitates return of the tRNA export receptors to the nucleus by inhibiting an unidentified activity that facilitates cytoplasmic accumulation of the tRNA export receptors when glucose in the environment is limiting. A PKA-independent mechanism was also found to regulate nuclear tRNA export in response to glucose availability. This mechanism, however, does not regulate nuclear reimport of the tRNA export receptors.

Protein Kinase A Is Part of a Mechanism That Regulates Nuclear Reimport of the Nuclear tRNA Export Receptors Los1p and Msn5p

PubMed Central

Pierce, Jacqueline B.; van der Merwe, George

2014-01-01

The two main signal transduction mechanisms that allow eukaryotes to sense and respond to changes in glucose availability in the environment are the cyclic AMP (cAMP)/protein kinase A (PKA) and AMP-activated protein kinase (AMPK)/Snf1 kinase-dependent pathways. Previous studies have shown that the nuclear tRNA export process is inhibited in Saccharomyces cerevisiae deprived of glucose. However, the signal transduction pathway involved and the mechanism by which glucose availability regulates nuclear-cytoplasmic tRNA trafficking are not understood. Here, we show that inhibition of nuclear tRNA export is caused by a block in nuclear reimport of the tRNA export receptors during glucose deprivation. Cytoplasmic accumulation of the tRNA export receptors during glucose deprivation is not caused by activation of Snf1p. Evidence obtained suggests that PKA is part of the mechanism that regulates nuclear reimport of the tRNA export receptors in response to glucose availability. This mechanism does not appear to involve phosphorylation of the nuclear tRNA export receptors by PKA. The block in nuclear reimport of the tRNA export receptors appears to be caused by activation of an unidentified mechanism when PKA is turned off during glucose deprivation. Taken together, the data suggest that PKA facilitates return of the tRNA export receptors to the nucleus by inhibiting an unidentified activity that facilitates cytoplasmic accumulation of the tRNA export receptors when glucose in the environment is limiting. A PKA-independent mechanism was also found to regulate nuclear tRNA export in response to glucose availability. This mechanism, however, does not regulate nuclear reimport of the tRNA export receptors. PMID:24297441

77 FR 70945 - Revisions to the Export Administration Regulations (EAR): Control of Military Electronic...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-28

... subparagraphs ranging from the lowest to the highest operating frequency ranges, with a gap for MMIC power... control high frequency (HF) surface wave radar capable of ``tracking'' surface targets on oceans... surreptitious interception of wire, oral, or electronic communications.'') Paragraph .c would control microwave...

15 CFR § 772.1 - Definitions of terms as used in the Export Administration Regulations (EAR).

Code of Federal Regulations, 2010 CFR

2017-01-01

... 15 Commerce and Foreign Trade 2 2017-01-01 2017-01-01 false Definitions of terms as used in the Export Administration Regulations (EAR). § 772.1 Section § 772.1 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE EXPORT ADMINISTRATION REGULATIONS...

15 CFR § 772.1 - Definitions of terms as used in the Export Administration Regulations (EAR).

Code of Federal Regulations, 2010 CFR

2018-01-01

... 15 Commerce and Foreign Trade 2 2018-01-01 2018-01-01 false Definitions of terms as used in the Export Administration Regulations (EAR). § 772.1 Section § 772.1 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE EXPORT ADMINISTRATION REGULATIONS...

15 CFR § 772.1 - Definitions of terms as used in the Export Administration Regulations (EAR).

Code of Federal Regulations, 2010 CFR

2015-01-01

... 15 Commerce and Foreign Trade 2 2015-01-01 2015-01-01 false Definitions of terms as used in the Export Administration Regulations (EAR). § 772.1 Section § 772.1 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE EXPORT ADMINISTRATION REGULATIONS...

15 CFR § 772.1 - Definitions of terms as used in the Export Administration Regulations (EAR).

Code of Federal Regulations, 2010 CFR

2016-01-01

... 15 Commerce and Foreign Trade 2 2016-01-01 2016-01-01 false Definitions of terms as used in the Export Administration Regulations (EAR). § 772.1 Section § 772.1 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE EXPORT ADMINISTRATION REGULATIONS...

15 CFR 754.7 - Petitions for the imposition of monitoring or controls on recyclable metallic materials; Public...

Code of Federal Regulations, 2010 CFR

2010-01-01

... monitoring or controls on recyclable metallic materials; Public hearings. 754.7 Section 754.7 Commerce and... SECURITY, DEPARTMENT OF COMMERCE EXPORT ADMINISTRATION REGULATIONS SHORT SUPPLY CONTROLS § 754.7 Petitions for the imposition of monitoring or controls on recyclable metallic materials; Public hearings. (a...

3 CFR - Continuation of Emergency Regarding Export Control Regulations

Code of Federal Regulations, 2010 CFR

2010-01-01

... year the national emergency declared in Executive Order 13222. This notice shall be published in the Federal Register and transmitted to the Congress.BARACK OBAMATHE WHITE HOUSE, August 13, 2009. ...

3 CFR - Continuation of Emergency Regarding Export Control Regulations

Code of Federal Regulations, 2011 CFR

2011-01-01

... year the national emergency declared in Executive Order 13222. This notice shall be published in the Federal Register and transmitted to the Congress.BARACK OBAMATHE WHITE HOUSE, August 12, 2010. ...

Role of transition metal exporters in virulence: the example of Neisseria meningitidis.

PubMed

Guilhen, Cyril; Taha, Muhamed-Kheir; Veyrier, Frédéric J

2013-01-01

Transition metals such as iron, manganese, and zinc are essential micronutrients for bacteria. However, at high concentration, they can generate non-functional proteins or toxic compounds. Metal metabolism is therefore regulated to prevent shortage or overload, both of which can impair cell survival. In addition, equilibrium among these metals has to be tightly controlled to avoid molecular replacement in the active site of enzymes. Bacteria must actively maintain intracellular metal concentrations to meet physiological needs within the context of the local environment. When intracellular buffering capacity is reached, they rely primarily on membrane-localized exporters to maintain metal homeostasis. Recently, several groups have characterized new export systems and emphasized their importance in the virulence of several pathogens. This article discusses the role of export systems as general virulence determinants. Furthermore, it highlights the contribution of these exporters in pathogens emergence with emphasis on the human nasopharyngeal colonizer Neisseria meningitidis.

mRNA export in the apicomplexan parasite Toxoplasma gondii: emerging divergent components of a crucial pathway.

PubMed

Ávila, Andréa Rodrigues; Cabezas-Cruz, Alexjandro; Gissot, Mathieu

2018-01-25

Control of gene expression is crucial for parasite survival and is the result of a series of processes that are regulated to permit fine-tuning of gene expression in response to biological changes during the life-cycle of apicomplexan parasites. Control of mRNA nuclear export is a key process in eukaryotic cells but is poorly understood in apicomplexan parasites. Here, we review recent knowledge regarding this process with an emphasis on T. gondii. We describe the presence of divergent orthologs and discuss structural and functional differences in export factors between apicomplexans and other eukaryotic lineages. Undoubtedly, the use of the CRISPR/Cas9 system in high throughput screenings associated with the discovery of mRNA nuclear export complexes by proteomic analysis will contribute to identify these divergent factors. Ligand-based or structure-based strategies may be applied to investigate the potential use of these proteins as targets for new antiprotozoal agents.

Regulation of nitrite transport in red blood cells by hemoglobin oxygen fractional saturation.

PubMed

Vitturi, Dario A; Teng, Xinjun; Toledo, José C; Matalon, Sadis; Lancaster, Jack R; Patel, Rakesh P

2009-05-01

Allosteric regulation of nitrite reduction by deoxyhemoglobin has been proposed to mediate nitric oxide (NO) formation during hypoxia. Nitrite is predominantly an anion at physiological pH, raising questions about the mechanism by which it enters the red blood cell (RBC) and whether this is regulated and coupled to deoxyhemoglobin-mediated reduction. We tested the hypothesis that nitrite transport by RBCs is regulated by fractional saturation. Using human RBCs, nitrite consumption was faster at lower fractional saturations, consistent with faster reactions with deoxyheme. A membrane-based regulation was suggested by slower nitrite consumption with intact versus lysed RBCs. Interestingly, upon nitrite addition, intracellular nitrite concentrations attained a steady state that, despite increased rates of consumption, did not change with decreasing oxygen tensions, suggesting a deoxygenation-sensitive step that either increases nitrite import or decreases the rate of nitrite export. A role for anion exchanger (AE)-1 in the control of nitrite export was suggested by increased intracellular nitrite concentrations in RBCs treated with DIDS. Moreover, deoxygenation decreased steady-state levels of intracellular nitrite in AE-1-inhibited RBCs. Based on these data, we propose a model in which deoxyhemoglobin binding to AE-1 inhibits nitrite export under low oxygen tensions allowing for the coupling between deoxygenation and nitrite reduction to NO along the arterial-to-venous gradient.

27 CFR 19.494 - Additional marks on portable containers.

Code of Federal Regulations, 2011 CFR

2011-04-01

...: (1) Without payment of tax, for export, for transfer to customs manufacturing bonded warehouses, for... required by Federal, State, or local law or regulations; wine or proof gallons; and plant control data...

77 FR 76864 - Amendment to the International Traffic in Arms Regulations: Afghanistan and Change to Policy on...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-31

... Belarus, Cuba, Eritrea, Iran, North Korea, Syria, and Venezuela. This policy also applies to countries... International Traffic in Arms Regulations: Afghanistan and Change to Policy on Prohibited Exports AGENCY.... Goforth, Director, Office of Defense Trade Controls Policy, U.S. Department of State, telephone (202) 663...

76 FR 76085 - Revisions to the Export Administration Regulations (EAR): Control of Military Vehicles and...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-06

... controls, even if those parts or components are ``specially designed'' for a defense article on the USML or... using broad, design-intent based catch- all controls over generic types of items such as ``parts'' and... that multilateral regimes do not require that the United States control non-significant parts and the...

31 CFR 515.559 - Certain transactions by U.S.-owned or controlled foreign firms with Cuba.

Code of Federal Regulations, 2011 CFR

2011-07-01

... controlled foreign firms with Cuba. 515.559 Section 515.559 Money and Finance: Treasury Regulations Relating... transactions by U.S.-owned or controlled foreign firms with Cuba. (a) Effective October 23, 1992, no specific... controlled firms in third countries and Cuba for the exportation to Cuba of commodities produced in the...

31 CFR 515.559 - Certain transactions by U.S.-owned or controlled foreign firms with Cuba.

Code of Federal Regulations, 2010 CFR

2010-07-01

... controlled foreign firms with Cuba. 515.559 Section 515.559 Money and Finance: Treasury Regulations Relating... transactions by U.S.-owned or controlled foreign firms with Cuba. (a) Effective October 23, 1992, no specific... controlled firms in third countries and Cuba for the exportation to Cuba of commodities produced in the...

31 CFR 515.559 - Certain transactions by U.S.-owned or controlled foreign firms with Cuba.

Code of Federal Regulations, 2012 CFR

2012-07-01

... controlled foreign firms with Cuba. 515.559 Section 515.559 Money and Finance: Treasury Regulations Relating... transactions by U.S.-owned or controlled foreign firms with Cuba. (a) Effective October 23, 1992, no specific... controlled firms in third countries and Cuba for the exportation to Cuba of commodities produced in the...

31 CFR 515.559 - Certain transactions by U.S.-owned or controlled foreign firms with Cuba.

Code of Federal Regulations, 2014 CFR

2014-07-01

... controlled foreign firms with Cuba. 515.559 Section 515.559 Money and Finance: Treasury Regulations Relating... transactions by U.S.-owned or controlled foreign firms with Cuba. (a) Effective October 23, 1992, no specific... controlled firms in third countries and Cuba for the exportation to Cuba of commodities produced in the...

31 CFR 515.559 - Certain transactions by U.S.-owned or controlled foreign firms with Cuba.

Code of Federal Regulations, 2013 CFR

2013-07-01

... controlled foreign firms with Cuba. 515.559 Section 515.559 Money and Finance: Treasury Regulations Relating... transactions by U.S.-owned or controlled foreign firms with Cuba. (a) Effective October 23, 1992, no specific... controlled firms in third countries and Cuba for the exportation to Cuba of commodities produced in the...

77 FR 25944 - Amendment to the International Traffic in Arms Regulations: Revision of U.S. Munitions List...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-02

... broadly controls, ``Any other explosive not elsewhere identified in this category specifically designed... State. ACTION: Proposed rule. SUMMARY: As part of the President's Export Control Reform effort, the... the U.S. Munitions List (USML) to describe more precisely the articles warranting control on the USML...

22 CFR 120.1 - General authorities and eligibility.

Code of Federal Regulations, 2013 CFR

2013-04-01

... Section 120.1 Foreign Relations DEPARTMENT OF STATE INTERNATIONAL TRAFFIC IN ARMS REGULATIONS PURPOSE AND DEFINITIONS § 120.1 General authorities and eligibility. (a) Section 38 of the Arms Export Control Act (22 U.S... Controls by this subchapter may be exercised at any time by the Under Secretary of State for Arms Control...

15 CFR 752.15 - Export clearance.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 15 Commerce and Foreign Trade 2 2013-01-01 2013-01-01 false Export clearance. 752.15 Section 752.15 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE EXPORT ADMINISTRATION REGULATIONS SPECIAL...

15 CFR 752.15 - Export clearance.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 15 Commerce and Foreign Trade 2 2011-01-01 2011-01-01 false Export clearance. 752.15 Section 752.15 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE EXPORT ADMINISTRATION REGULATIONS SPECIAL...

15 CFR 752.15 - Export clearance.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 15 Commerce and Foreign Trade 2 2014-01-01 2014-01-01 false Export clearance. 752.15 Section 752.15 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE EXPORT ADMINISTRATION REGULATIONS SPECIAL...

15 CFR 742.3 - Nuclear nonproliferation.

Code of Federal Regulations, 2012 CFR

2012-01-01

...) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE EXPORT ADMINISTRATION REGULATIONS CONTROL POLICY-CCL BASED CONTROLS § 742.3 Nuclear nonproliferation. (a) License requirements. Section 309(c) of the Nuclear Non-Proliferation Act of 1978 requires BIS to identify items subject to the EAR that could be of...

15 CFR 742.3 - Nuclear nonproliferation.

Code of Federal Regulations, 2014 CFR

2014-01-01

...) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE EXPORT ADMINISTRATION REGULATIONS CONTROL POLICY-CCL BASED CONTROLS § 742.3 Nuclear nonproliferation. (a) License requirements. Section 309(c) of the Nuclear Non-Proliferation Act of 1978 requires BIS to identify items subject to the EAR that could be of...

15 CFR 742.3 - Nuclear nonproliferation.

Code of Federal Regulations, 2011 CFR

2011-01-01

...) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE EXPORT ADMINISTRATION REGULATIONS CONTROL POLICY-CCL BASED CONTROLS § 742.3 Nuclear nonproliferation. (a) License requirements. Section 309(c) of the Nuclear Non-Proliferation Act of 1978 requires BIS to identify items subject to the EAR that could be of...

15 CFR 742.3 - Nuclear nonproliferation.

Code of Federal Regulations, 2010 CFR

2010-01-01

...) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE EXPORT ADMINISTRATION REGULATIONS CONTROL POLICY-CCL BASED CONTROLS § 742.3 Nuclear nonproliferation. (a) License requirements. Section 309(c) of the Nuclear Non-Proliferation Act of 1978 requires BIS to identify items subject to the EAR that could be of...

15 CFR 742.3 - Nuclear nonproliferation.

Code of Federal Regulations, 2013 CFR

2013-01-01

...) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE EXPORT ADMINISTRATION REGULATIONS CONTROL POLICY-CCL BASED CONTROLS § 742.3 Nuclear nonproliferation. (a) License requirements. Section 309(c) of the Nuclear Non-Proliferation Act of 1978 requires BIS to identify items subject to the EAR that could be of...

22 CFR 127.1 - Violations.

Code of Federal Regulations, 2010 CFR

2010-04-01

... Relations DEPARTMENT OF STATE INTERNATIONAL TRAFFIC IN ARMS REGULATIONS VIOLATIONS AND PENALTIES § 127.1... Directorate of Defense Trade Controls; (2) To import or attempt to import any defense article whenever a... from the Directorate of Defense Trade Controls; (3) To conspire to export, import, reexport or cause to...

15 CFR 752.15 - Export clearance.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 15 Commerce and Foreign Trade 2 2010-01-01 2010-01-01 false Export clearance. 752.15 Section 752... OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE EXPORT ADMINISTRATION REGULATIONS SPECIAL COMPREHENSIVE LICENSE § 752.15 Export clearance. (a) Shipper's Export Declaration (SED) or Automated Export...

Space Science and the International Traffic in Arms Regulations: Summary of a Workshop

NASA Technical Reports Server (NTRS)

Finarelli, Margaret G.; Alexander, Joseph K.

2008-01-01

The United States seeks to protect its security and foreign-policy interests, in part, by actively controlling the export of goods, technologies, and services that are or may be useful for military development in other nations. "Export" is defined not simply as the sending abroad of hardware but also as the communication of related technology and know-how to foreigners in the United States and overseas. The U.S. government mechanism for controlling dual-use items--items in commerce that have potential military use is the Export Administration Regulations (EAR) administered by the Department of Commerce; items defined in law as defense articles fall under the jurisdiction of the Department of State and the International Traffic in Arms Regulations (ITAR). Because of the potential military implications of the export of defense articles, the ITAR regime imposes much greater burdens (on both the applicant and the government) than does the EAR regime during the process of applying for, and implementing the provisions of, licenses and technical-assistance agreements. Until the early 1990s export control activity related to all space satellites (commercial and scientific) was handled under ITAR. Between 1992 and 1996 the George H.W. Bush and the Clinton administrations transferred jurisdiction over the licensing of civilian communications satellites to the Commerce Department under EAR. In 1999, however, in response to broad concerns about Chinese attempts to acquire U.S. high technology, the U.S. House of Representatives convened the Select Committee on U.S. National Security and Military/Commercial Concerns with the People s Republic of China, also known as the Cox Committee. One of the many consequences of the Cox Committee's report was Congress's mandate that jurisdiction over export and licensing of satellites and related equipment and services, irrespective of military utility, be transferred from the Department of Commerce to the State Department and that such equipment and services be covered as defense articles under ITAR. Scientific satellites were explicitly included despite their use for decades in peaceful internationally conducted cooperative scientific research. It is widely recognized that the shift in regulatory regime from EAR to ITAR has had major deleterious effects on international scientific research activities that depend on satellites, spaceflight hardware, and other items that are now controlled by ITAR. Furthermore, contravening U.S. interests in attracting foreign students to U.S. universities, the capture of space technology by ITAR has caused serious problems in the teaching of university space science and engineering classes, virtually all of which include non-U.S. students. This report is a summary of a September 2007 workshop in which participants from the space research communities and the export-control administration and policy communities came together to discuss problems, effects, and potential solutions regarding the application of ITAR to space science. The principal themes and ideas that emerged from the discussions are summarized.

78 FR 45026 - Revisions to the Export Administration Regulations (EAR): Control of Military Electronic...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-25

... bear no direct correlation to military-specific applications in accordance with the stated intention... logical correlation to the way that discrete microwave transistors and MMIC technologies actually work...

15 CFR 734.11 - Government-sponsored research covered by contract controls.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 15 Commerce and Foreign Trade 2 2010-01-01 2010-01-01 false Government-sponsored research covered by contract controls. 734.11 Section 734.11 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE EXPORT...

76 FR 80291 - Revisions to the Export Administration Regulations (EAR): Control of Submersible Vessels...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-23

..., unilateral control on submersibles ``specially designed'' for cargo transport that are not currently subject to USML or CCL controls. This rule is one of a planned series of proposed rules that are part of the... controlled on the CCL--the military vehicles proposal was the first in a series of such proposed rules to be...

78 FR 37371 - Wassenaar Arrangement 2012 Plenary Agreements Implementation: Commerce Control List, Definitions...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-20

...The Bureau of Industry and Security (BIS) maintains, as part of its Export Administration Regulations (EAR), the Commerce Control List (CCL), which identifies certain of the items subject to Department of Commerce jurisdiction. This final rule revises the CCL to implement changes made to the Wassenaar Arrangement's List of Dual-Use Goods and Technologies (Wassenaar List) maintained and agreed to by governments participating in the Wassenaar Arrangement on Export Controls for Conventional Arms and Dual-Use Goods and Technologies (Wassenaar Arrangement, or WA) at the December 2012 WA Plenary Meeting (the Plenary). The Wassenaar Arrangement advocates implementation of effective export controls on strategic items with the objective of improving regional and international security and stability. This rule harmonizes the CCL with the changes made to the WA List at the Plenary by revising ECCNs controlled for national security reasons in each category of the CCL, except category 8, as well as amending the General Software Note, WA reporting requirements, and definitions section in the EAR. BIS is adding unilateral controls to the CCL for specific software and technology for aviation control systems, which the WA agreements removed from the WA List, i.e., EAR national security controls.

Regulation of the Drosophila Hypoxia-Inducible Factor α Sima by CRM1-Dependent Nuclear Export ▿

PubMed Central

Romero, Nuria M.; Irisarri, Maximiliano; Roth, Peggy; Cauerhff, Ana; Samakovlis, Christos; Wappner, Pablo

2008-01-01

Hypoxia-inducible factor α (HIF-α) proteins are regulated by oxygen levels through several different mechanisms that include protein stability, transcriptional coactivator recruitment, and subcellular localization. It was previously reported that these transcription factors are mainly nuclear in hypoxia and cytoplasmic in normoxia, but so far the molecular basis of this regulation is unclear. We show here that the Drosophila melanogaster HIF-α protein Sima shuttles continuously between the nucleus and the cytoplasm. We identified the relevant nuclear localization signal and two functional nuclear export signals (NESs). These NESs are in the Sima basic helix-loop-helix (bHLH) domain and promote CRM1-dependent nuclear export. Site-directed mutagenesis of either NES provoked Sima nuclear retention and increased transcriptional activity, suggesting that nuclear export contributes to Sima regulation. The identified NESs are conserved and probably functional in the bHLH domains of several bHLH-PAS proteins. We propose that rapid nuclear export of Sima regulates the duration of cellular responses to hypoxia. PMID:18332128

77 FR 35317 - Amendment to the International Traffic in Arms Regulations: Revision of U.S. Munitions List...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-13

... State. ACTION: Proposed rule. SUMMARY: As part of the President's Export Control Reform effort, the... materials warranting control on the USML. The revisions to this rule are part of the Department of State's... Directorate of Defense Trade Controls Web site at www.pmddtc.state.gov . Parties who wish to comment...

15 CFR 748.11 - Statement by Ultimate Consignee and Purchaser.

Code of Federal Regulations, 2012 CFR

2012-01-01

..., and denial, in whole or in part, of participation in U.S. exports or reexports. (ii) Except as specifically authorized by the U.S. Export Administration Regulations, or by written approval from the Bureau... contrary to the U.S. Export Administration Regulations. (iii) We understand that acceptance of this...

15 CFR 748.11 - Statement by Ultimate Consignee and Purchaser.

Code of Federal Regulations, 2014 CFR

2014-01-01

..., and denial, in whole or in part, of participation in U.S. exports or reexports. (ii) Except as specifically authorized by the U.S. Export Administration Regulations, or by written approval from the Bureau... contrary to the U.S. Export Administration Regulations. (iii) We understand that acceptance of this...

15 CFR 748.11 - Statement by Ultimate Consignee and Purchaser.

Code of Federal Regulations, 2013 CFR

2013-01-01

..., and denial, in whole or in part, of participation in U.S. exports or reexports. (ii) Except as specifically authorized by the U.S. Export Administration Regulations, or by written approval from the Bureau... contrary to the U.S. Export Administration Regulations. (iii) We understand that acceptance of this...

15 CFR 730.3 - Dual use exports.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 15 Commerce and Foreign Trade 2 2010-01-01 2010-01-01 false Dual use exports. 730.3 Section 730.3 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE EXPORT ADMINISTRATION REGULATIONS GENERAL INFORMATION § 730.3...

31 CFR 537.305 - Exportation or reexportation of financial services to Burma.

Code of Federal Regulations, 2010 CFR

2010-07-01

... financial services to Burma. 537.305 Section 537.305 Money and Finance: Treasury Regulations Relating to... SANCTIONS REGULATIONS General Definitions § 537.305 Exportation or reexportation of financial services to Burma. The term exportation or reexportation of financial services to Burma means: (a) The transfer of...

31 CFR 537.202 - Prohibited exportation or reexportation of financial services to Burma.

Code of Federal Regulations, 2010 CFR

2010-07-01

... reexportation of financial services to Burma. 537.202 Section 537.202 Money and Finance: Treasury Regulations... permit granted prior to July 29, 2003, the exportation or reexportation of financial services to Burma... BURMESE SANCTIONS REGULATIONS Prohibitions § 537.202 Prohibited exportation or reexportation of financial...

31 CFR 538.510 - Importation and exportation of certain gifts authorized.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 31 Money and Finance:Treasury 3 2011-07-01 2011-07-01 false Importation and exportation of certain gifts authorized. 538.510 Section 538.510 Money and Finance: Treasury Regulations Relating to Money and... REGULATIONS Licenses, Authorizations, and Statements of Licensing Policy § 538.510 Importation and exportation...

31 CFR 538.510 - Importation and exportation of certain gifts authorized.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 31 Money and Finance:Treasury 3 2014-07-01 2014-07-01 false Importation and exportation of certain gifts authorized. 538.510 Section 538.510 Money and Finance: Treasury Regulations Relating to Money and... REGULATIONS Licenses, Authorizations, and Statements of Licensing Policy § 538.510 Importation and exportation...

31 CFR 538.510 - Importation and exportation of certain gifts authorized.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 31 Money and Finance:Treasury 3 2013-07-01 2013-07-01 false Importation and exportation of certain gifts authorized. 538.510 Section 538.510 Money and Finance: Treasury Regulations Relating to Money and... REGULATIONS Licenses, Authorizations, and Statements of Licensing Policy § 538.510 Importation and exportation...

48 CFR 552.211-88 - Vehicle export preparation.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 48 Federal Acquisition Regulations System 4 2013-10-01 2013-10-01 false Vehicle export preparation. 552.211-88 Section 552.211-88 Federal Acquisition Regulations System GENERAL SERVICES ADMINISTRATION CLAUSES AND FORMS SOLICITATION PROVISIONS AND CONTRACT CLAUSES Text of Provisions and Clauses 552.211-88 Vehicle export preparation. As prescribed...

NMD3 regulates both mRNA and rRNA nuclear export in African trypanosomes via an XPOI-linked pathway

PubMed Central

Bühlmann, Melanie; Walrad, Pegine; Rico, Eva; Ivens, Alasdair; Capewell, Paul; Naguleswaran, Arunasalam; Roditi, Isabel; Matthews, Keith R.

2015-01-01

Trypanosomes mostly regulate gene expression through post-transcriptional mechanisms, particularly mRNA stability. However, much mRNA degradation is cytoplasmic such that mRNA nuclear export must represent an important level of regulation. Ribosomal RNAs must also be exported from the nucleus and the trypanosome orthologue of NMD3 has been confirmed to be involved in rRNA processing and export, matching its function in other organisms. Surprisingly, we found that TbNMD3 depletion also generates mRNA accumulation of procyclin-associated genes (PAGs), these being co-transcribed by RNA polymerase I with the procyclin surface antigen genes expressed on trypanosome insect forms. By whole transcriptome RNA-seq analysis of TbNMD3-depleted cells we confirm the regulation of the PAG transcripts by TbNMD3 and using reporter constructs reveal that PAG1 regulation is mediated by its 5′UTR. Dissection of the mechanism of regulation demonstrates that it is not dependent upon translational inhibition mediated by TbNMD3 depletion nor enhanced transcription. However, depletion of the nuclear export factors XPO1 or MEX67 recapitulates the effects of TbNMD3 depletion on PAG mRNAs and mRNAs accumulated in the nucleus of TbNMD3-depleted cells. These results invoke a novel RNA regulatory mechanism involving the NMD3-dependent nuclear export of mRNA cargos, suggesting a shared platform for mRNA and rRNA export. PMID:25873624

Glycogen synthase kinase-3 enhances nuclear export of a Dictyostelium STAT protein

PubMed Central

Ginger, Rebecca S.; Dalton, Emma C.; Ryves, W.Jonathan; Fukuzawa, Masashi; Williams, Jeffrey G.; Harwood, Adrian J.

2000-01-01

Extracellular cAMP stimulates the rapid tyrosine phosphorylation and nuclear translocation of the Dictyostelium STAT protein Dd-STATa. Here we show that it also induces serine phosphorylation by GskA, a homologue of glycogen synthase kinase-3 (GSK-3). Tyrosine phosphorylation occurs within 10 s of stimulation, whereas serine phosphorylation takes 5 min, matching the kinetics observed for the cAMP regulation of GskA. Phosphorylation by GskA enhances nuclear export of Dd-STATa. The phosphorylated region, however, is not itself a nuclear export signal and we identify a region elsewhere in the protein that mediates nuclear export. These results suggest a biphasic regulation of Dd-STATa, in which extracellular cAMP initially directs nuclear import and then, via GskA, promotes its subsequent export. It also raises the possibility of an analogous regulation of STAT nuclear export in higher eukaryotes. PMID:11032815

7 CFR 51.2840 - Export packing requirements.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 2 2010-01-01 2010-01-01 false Export packing requirements. 51.2840 Section 51.2840 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards...) Export Packing Requirements § 51.2840 Export packing requirements. Onions specified as meeting Export...

78 FR 67927 - Foreign Trade Regulations (FTR): Mandatory Automated Export System Filing for All Shipments...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-11-13

... 0607-AA50 Foreign Trade Regulations (FTR): Mandatory Automated Export System Filing for All Shipments... an existing information collection and the collection of two new data elements in the Automated... report shipments of used self-propelled vehicles and temporary exports through the AES or through...

APHIS (PPQ) exotic pest detection

Treesearch

David R. Lance

2003-01-01

The legally mandated responsibilities of APHIS Plant Protection and Quarantine (PPQ) include: (1) Protect American agriculture from foreign plant pest introduction and establishment, (2) facilitate export of American agricultural products, and (3) control or eradicate pests as authorized by legislation and regulation.

22 CFR 120.1 - General authorities and eligibility.

Code of Federal Regulations, 2010 CFR

2010-04-01

... Section 120.1 Foreign Relations DEPARTMENT OF STATE INTERNATIONAL TRAFFIC IN ARMS REGULATIONS PURPOSE AND DEFINITIONS § 120.1 General authorities and eligibility. (a) Section 38 of the Arms Export Control Act (22 U.S... any time by the Under Secretary of State for Arms Control and International Security or the Assistant...

22 CFR 120.1 - General authorities and eligibility.

Code of Federal Regulations, 2011 CFR

2011-04-01

... Section 120.1 Foreign Relations DEPARTMENT OF STATE INTERNATIONAL TRAFFIC IN ARMS REGULATIONS PURPOSE AND DEFINITIONS § 120.1 General authorities and eligibility. (a) Section 38 of the Arms Export Control Act (22 U.S... any time by the Under Secretary of State for Arms Control and International Security or the Assistant...

Effects of box liner perforation area on methyl bromide diffusion into table grape packages during fumigation

USDA-ARS?s Scientific Manuscript database

Plastic liners are used inside boxes of table grapes to retard moisture loss from the grapes and to contain sulfur dioxide gas released inside the packages to control postharvest decay. However, to control organisms of quarantine concern, regulators specify exported packages must be fumigated with m...

22 CFR 123.9 - Country of ultimate destination and approval of reexports or retransfers.

Code of Federal Regulations, 2014 CFR

2014-04-01

... subchapter as Missile Technology Control Regime (MTCR) items; and (3) The person reexporting the defense... ARMS REGULATIONS LICENSES FOR THE EXPORT AND TEMPORARY IMPORT OF DEFENSE ARTICLES § 123.9 Country of... written approval of the Directorate of Defense Trade Controls must be obtained before reselling...

Localization of Nucleoporin Tpr to the Nuclear Pore Complex Is Essential for Tpr Mediated Regulation of the Export of Unspliced RNA

PubMed Central

Rajanala, Kalpana; Nandicoori, Vinay Kumar

2012-01-01

Nucleoporin Tpr is a component of the nuclear pore complex (NPC) that localizes exclusively to intranuclear filaments. Tpr functions as a scaffolding element in the nuclear phase of the NPC and plays a role in mitotic spindle checkpoint signalling. Export of intron-containing mRNA in Mason Pfizer Monkey Virus is regulated by direct interaction of cellular proteins with the cis-acting Constitutive Transport Element (CTE). In mammalian cells, the transport of Gag/Pol-CTE reporter construct is not very efficient, suggesting a regulatory mechanism to retain this unspliced RNA. Here we report that the knockdown of Tpr in mammalian cells leads to a drastic enhancement in the levels of Gag proteins (p24) in the cytoplasm, which is rescued by siRNA resistant Tpr. Tpr's role in the retention of unspliced RNA is independent of the functions of Sam68 and Tap/Nxf1 proteins, which are reported to promote CTE dependent export. Further, we investigated the possible role for nucleoporins that are known to function in nucleocytoplasmic transport in modulating unspliced RNA export. Results show that depletion of Nup153, a nucleoporin required for NPC anchoring of Tpr, plays a role in regulating the export, while depletion of other FG repeat-containing nucleoporins did not alter the unspliced RNA export. Results suggest that Tpr and Nup153 both regulate the export of unspliced RNA and they are most likely functioning through the same pathway. Importantly, we find that localization of Tpr to the NPC is necessary for Tpr mediated regulation of unspliced RNA export. Collectively, the data indicates that perinuclear localization of Tpr at the nucleopore complex is crucial for regulating intron containing mRNA export by directly or indirectly participating in the processing and degradation of aberrant mRNA transcripts. PMID:22253824

The international political economy of food: a global crisis.

PubMed

Friedmann, H

1995-01-01

The largest gap between national regulation and transnational economic organization is in the agro-food sector. This gap is the legacy of the post-World War II food regime, whose implicit rules gave priority to national farm programs (including import controls and export subsidies); placed the United States at the center; generated chronic surpluses; and allowed international power to take the unusual form of subsidized exports of surplus commodities, particularly wheat. The author analyzes the emergence and contradictions of the postwar food regime as a tension between replication and integration of national agro-food sectors, often interpreted as "export of the U.S. model." By the early 1970s, replication led to international economic conflict, while transnational corporations found national regulatory frameworks to be obstacles to further integration of a potentially global agro-food sector. A new axis between Asian import countries and new agricultural countries, such as Brazil, has destabilized the Atlantic-centered food regime, without creating a new regime. Alternative future regime are identified, based on the shift from agriculture to food, employment, and land use as political issues: private global regulation or democratic regulation of nested, regional agro-food economies, federated at the international level.

15 CFR 772.1 - Definitions of terms as used in the Export Administration Regulations (EAR).

Code of Federal Regulations, 2010 CFR

2010-01-01

..., but not a physical change in wiring or interconnections. Digital transfer rate. (Cat 5)—The total bit...) means an electronic control system for gas turbine or combined cycle engines utilizing a digital...

22 CFR 120.3 - Policy on designating and determining defense articles and services.

Code of Federal Regulations, 2010 CFR

2010-04-01

... ARMS REGULATIONS PURPOSE AND DEFINITIONS § 120.3 Policy on designating and determining defense articles... shall be changed only by amendments made pursuant to section 38 of the Arms Export Control Act (22 U.S.C...

22 CFR 120.3 - Policy on designating and determining defense articles and services.

Code of Federal Regulations, 2011 CFR

2011-04-01

... ARMS REGULATIONS PURPOSE AND DEFINITIONS § 120.3 Policy on designating and determining defense articles... shall be changed only by amendments made pursuant to section 38 of the Arms Export Control Act (22 U.S.C...

22 CFR 120.3 - Policy on designating and determining defense articles and services.

Code of Federal Regulations, 2013 CFR

2013-04-01

... ARMS REGULATIONS PURPOSE AND DEFINITIONS § 120.3 Policy on designating and determining defense articles... shall be changed only by amendments made pursuant to section 38 of the Arms Export Control Act (22 U.S.C...

22 CFR 120.3 - Policy on designating and determining defense articles and services.

Code of Federal Regulations, 2012 CFR

2012-04-01

... ARMS REGULATIONS PURPOSE AND DEFINITIONS § 120.3 Policy on designating and determining defense articles... shall be changed only by amendments made pursuant to section 38 of the Arms Export Control Act (22 U.S.C...

48 CFR 552.211-88 - Vehicle export preparation.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 48 Federal Acquisition Regulations System 4 2012-10-01 2012-10-01 false Vehicle export preparation... Vehicle export preparation. As prescribed in 511.204(b)(8), insert the following clause: Vehicle Export Preparation (JAN 2010) Vehicles shall be prepared for export on wheels, unboxed, unless otherwise specified in...

48 CFR 552.211-88 - Vehicle export preparation.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 48 Federal Acquisition Regulations System 4 2014-10-01 2014-10-01 false Vehicle export preparation... Vehicle export preparation. As prescribed in 511.204(b)(8), insert the following clause: Vehicle Export Preparation (JAN 2010) Vehicles shall be prepared for export on wheels, unboxed, unless otherwise specified in...

76 FR 11756 - Action Affecting Export Privileges; Ali Amirnazmi; Order Denying Export Privileges

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-03

... DEPARTMENT OF COMMERCE Bureau of Industry and Security Action Affecting Export Privileges; Ali Amirnazmi; Order Denying Export Privileges In the Matter of: Ali Amirnazmi, Register 63302-066, FCI... release and forfeit $81,277.37. Section 766.25 of the Export Administration Regulations (``EAR'' or...

7 CFR 35.8 - Date of export.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 2 2010-01-01 2010-01-01 false Date of export. 35.8 Section 35.8 Agriculture... Practices), DEPARTMENT OF AGRICULTURE COMMODITY STANDARDS AND STANDARD CONTAINER REGULATIONS EXPORT GRAPES AND PLUMS Definitions § 35.8 Date of export. Date of export means the date of loading on board the...

48 CFR 552.211-88 - Vehicle export preparation.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Vehicle export preparation... Vehicle export preparation. As prescribed in 511.204(b)(8), insert the following clause: Vehicle Export Preparation (JAN 2010) Vehicles shall be prepared for export on wheels, unboxed, unless otherwise specified in...

INTRACELLULAR CHOLESTEROL HOMEOSTASIS AND AMYLOID PRECURSOR PROTEIN PROCESSING

PubMed Central

Burns, Mark; Rebeck, G. William

2010-01-01

Many preclinical and clinical studies have implied a role for cholesterol in the pathogenesis of Alzheimer's disease (AD). In this review we will discuss the movement of intracellular cholesterol and how normal distribution, transport, and export of cholesterol is vital for regulation of the AD related protein, Aβ. We focus on cholesterol distribution in the plasma membrane, transport through the endosomal/lysosomal system, control of cholesterol intracellular signaling at the endoplasmic reticulum and Golgi, the HMG-CoA reductase pathway and finally export of cholesterol from the cell. PMID:20304094

31 CFR 542.510 - Exports or reexports to Syria of items licensed or otherwise authorized by the Department of...

Code of Federal Regulations, 2014 CFR

2014-07-01

... services authorized. 542.510 Section 542.510 Money and Finance: Treasury Regulations Relating to Money and... REGULATIONS Licenses, Authorizations, and Statements of Licensing Policy § 542.510 Exports or reexports to.... Note to § 542.510: This section does not authorize the exportation or reexportation of any item not...

15 CFR 30.71 - False or fraudulent reporting on or misuse of the Automated Export System.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 15 Commerce and Foreign Trade 1 2010-01-01 2010-01-01 false False or fraudulent reporting on or misuse of the Automated Export System. 30.71 Section 30.71 Commerce and Foreign Trade Regulations... REGULATIONS Penalties § 30.71 False or fraudulent reporting on or misuse of the Automated Export System. (a...

31 CFR 8.3 - Conference and practice requirements.

Code of Federal Regulations, 2010 CFR

2010-07-01

... requirements for powers of attorney are set forth in: (a) 26 CFR part 601, subpart E (or those regulations as... issued under the Arms Export Control Act (22 U.S.C. 2778); (d) 27 CFR part 178, subpart E, with respect to proceedings concerning licenses issued under the Gun Control Act of 1968 (18 U.S.C. Chapter 44...

Phage insertion in mlrA and variations in rpoS limit curli expression and biofilm formation in Escherichia coli serotype O157:H7

USDA-ARS?s Scientific Manuscript database

Biofilm formation in Escherichia coli is a tightly controlled process requiring the expression of adhesive curli fibers and certain polysaccharides such as cellulose. The transcriptional regulator CsgD is central to biofilm formation, controlling the expression of the curli structural and export pro...

15 CFR 744.11 - License requirements that apply to entities acting contrary to the national security or foreign...

Code of Federal Regulations, 2011 CFR

2011-01-01

... activity. (4) Preventing accomplishment of an end use check conducted by or on behalf of BIS or the Directorate of Defense Trade Controls of the Department of State by: precluding access to; refusing to provide...) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE EXPORT ADMINISTRATION REGULATIONS CONTROL POLICY...

15 CFR 744.11 - License requirements that apply to entities acting contrary to the national security or foreign...

Code of Federal Regulations, 2012 CFR

2012-01-01

... activity. (4) Preventing accomplishment of an end use check conducted by or on behalf of BIS or the Directorate of Defense Trade Controls of the Department of State by: precluding access to; refusing to provide...) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE EXPORT ADMINISTRATION REGULATIONS CONTROL POLICY...

15 CFR 744.11 - License requirements that apply to entities acting contrary to the national security or foreign...

Code of Federal Regulations, 2014 CFR

2014-01-01

... activity. (4) Preventing accomplishment of an end use check conducted by or on behalf of BIS or the Directorate of Defense Trade Controls of the Department of State by: precluding access to; refusing to provide...) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE EXPORT ADMINISTRATION REGULATIONS CONTROL POLICY...

15 CFR 744.11 - License requirements that apply to entities acting contrary to the national security or foreign...

Code of Federal Regulations, 2010 CFR

2010-01-01

... activity. (4) Preventing accomplishment of an end use check conducted by or on behalf of BIS or the Directorate of Defense Trade Controls of the Department of State by: precluding access to; refusing to provide...) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE EXPORT ADMINISTRATION REGULATIONS CONTROL POLICY...

78 FR 60250 - Order Denying Export Privileges

Federal Register 2010, 2011, 2012, 2013, 2014

2013-10-01

... DEPARTMENT OF COMMERCE Bureau of Industry and Security Order Denying Export Privileges In the... knowingly and willfully causing and attempting to cause the export of digital microwave radios to Iran.... Section 766.25 of the Export Administration Regulations (``EAR'' or [[Page 60251

7 CFR 1493.220 - Exporter eligibility.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 7 Agriculture 10 2012-01-01 2012-01-01 false Exporter eligibility. 1493.220 Section 1493.220 Agriculture Regulations of the Department of Agriculture (Continued) COMMODITY CREDIT CORPORATION, DEPARTMENT OF AGRICULTURE EXPORT PROGRAMS CCC EXPORT CREDIT GUARANTEE PROGRAMS CCC Facility Guarantee Program...

7 CFR 1493.220 - Exporter eligibility.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 7 Agriculture 10 2014-01-01 2014-01-01 false Exporter eligibility. 1493.220 Section 1493.220 Agriculture Regulations of the Department of Agriculture (Continued) COMMODITY CREDIT CORPORATION, DEPARTMENT OF AGRICULTURE EXPORT PROGRAMS CCC EXPORT CREDIT GUARANTEE PROGRAMS CCC Facility Guarantee Program...

7 CFR 1493.220 - Exporter eligibility.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 7 Agriculture 10 2013-01-01 2013-01-01 false Exporter eligibility. 1493.220 Section 1493.220 Agriculture Regulations of the Department of Agriculture (Continued) COMMODITY CREDIT CORPORATION, DEPARTMENT OF AGRICULTURE EXPORT PROGRAMS CCC EXPORT CREDIT GUARANTEE PROGRAMS CCC Facility Guarantee Program...

Mapping forest risk associated with beech bark disease

Treesearch

Andrew M. Liebhold; Randall S. Morin; Andrew Lister; Kurt W. Gottschalk; Eugene Luzader; Daniel Twardus

2003-01-01

The legally mandated responsibilities of APHIS Plant Protection and Quarantine (PPQ) include: (1) Protect American agriculture from foreign plant pest introduction and establishment, (2) facilitate export of American agricultural products, and (3) control or eradicate pests as authorized by legislation and regulation.

22 CFR 123.17 - Exports of firearms, ammunition, and personal protective gear.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 22 Foreign Relations 1 2013-04-01 2013-04-01 false Exports of firearms, ammunition, and personal... REGULATIONS LICENSES FOR THE EXPORT OF DEFENSE ARTICLES § 123.17 Exports of firearms, ammunition, and personal...; (2) The firearms and accompanying ammunition to be exported is with the individual's baggage or...

7 CFR 915.12 - Export.

Code of Federal Regulations, 2013 CFR

2013-01-01

... ORDERS; FRUITS, VEGETABLES, NUTS), DEPARTMENT OF AGRICULTURE AVOCADOS GROWN IN SOUTH FLORIDA Order Regulating Handling Definitions § 915.12 Export. Export means to ship avocados to any destination which is...

7 CFR 915.12 - Export.

Code of Federal Regulations, 2012 CFR

2012-01-01

... Orders; Fruits, Vegetables, Nuts), DEPARTMENT OF AGRICULTURE AVOCADOS GROWN IN SOUTH FLORIDA Order Regulating Handling Definitions § 915.12 Export. Export means to ship avocados to any destination which is...

27 CFR 4.80 - Exports.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Exports. 4.80 Section 4.80... TREASURY LIQUORS LABELING AND ADVERTISING OF WINE General Provisions § 4.80 Exports. The regulations in this part shall not apply to wine exported in bond. ...

7 CFR 947.17 - Export.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 8 2010-01-01 2010-01-01 false Export. 947.17 Section 947.17 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and... Definitions § 947.17 Export. Export means shipment of potatoes beyond the boundaries of continental United...

GABAB receptor cell surface export is controlled by an endoplasmic reticulum gatekeeper

PubMed Central

Doly, Stéphane; Shirvani, Hamasseh; Gäta, Gabriel; Meye, Frank; Emerit, Michel-Boris; Enslen, Hervé; Achour, Lamia; Pardo-Lopez, Liliana; Kwon, Yang Seung; Armand, Vincent; Gardette, Robert; Giros, Bruno; Gassmann, Martin; Bettler, Bernhard; Mameli, Manuel; Darmon, Michèle; Marullo, Stefano

2016-01-01

Summary Endoplasmic reticulum (ER) release and cell surface export of many G protein-coupled receptors (GPCRs), are tightly regulated. For GABAB receptors of GABA, the major mammalian inhibitory neurotransmitter, the ligand-binding GB1 subunit is maintained in the ER by unknown mechanisms in the absence of hetero-dimerization with the GB2 subunit. We report that GB1 retention is regulated by a specific gatekeeper, PRAF2. This ER resident transmembrane protein binds to GB1, preventing its progression in the biosynthetic pathway. GB1 release occurs upon competitive displacement from PRAF2 by GB2. PRAF2 concentration, relative to that of GB1 and GB2, tightly controls cell surface receptor density and controls GABAB function in neurons. Experimental perturbation of PRAF2 levels in vivo caused marked hyperactivity disorders in mice. These data reveal an unanticipated major impact of specific ER gate-keepers on GPCR function and identify PRAF2 as a new molecular target with therapeutic potential for psychiatric and neurological diseases involving GABAB function. PMID:26033241

7 CFR 35.12 - Inspection and certification.

Code of Federal Regulations, 2010 CFR

2010-01-01

... REGULATIONS EXPORT GRAPES AND PLUMS Regulations § 35.12 Inspection and certification. (a) Each person shipping... other than destinations in Canada or Mexico, shall cause them to be inspected within 14 days prior to date of export by the Federal or Federal-State Inspection Service in accordance with regulations...

Nucleocytoplasmic Transport of RNAs and RNA-Protein Complexes.

PubMed

Sloan, Katherine E; Gleizes, Pierre-Emmanuel; Bohnsack, Markus T

2016-05-22

RNAs and ribonucleoprotein complexes (RNPs) play key roles in mediating and regulating gene expression. In eukaryotes, most RNAs are transcribed, processed and assembled with proteins in the nucleus and then either function in the cytoplasm or also undergo a cytoplasmic phase in their biogenesis. This compartmentalization ensures that sequential steps in gene expression and RNP production are performed in the correct order and it allows important quality control mechanisms that prevent the involvement of aberrant RNAs/RNPs in these cellular pathways. The selective exchange of RNAs/RNPs between the nucleus and cytoplasm is enabled by nuclear pore complexes, which function as gateways between these compartments. RNA/RNP transport is facilitated by a range of nuclear transport receptors and adaptors, which are specifically recruited to their cargos and mediate interactions with nucleoporins to allow directional translocation through nuclear pore complexes. While some transport factors are only responsible for the export/import of a certain class of RNA/RNP, others are multifunctional and, in the case of large RNPs, several export factors appear to work together to bring about export. Recent structural studies have revealed aspects of the mechanisms employed by transport receptors to enable specific cargo recognition, and genome-wide approaches have provided the first insights into the diverse composition of pre-mRNPs during export. Furthermore, the regulation of RNA/RNP export is emerging as an important means to modulate gene expression under stress conditions and in disease. Copyright © 2015. Published by Elsevier Ltd.

22 CFR 123.22 - Filing, retention, and return of export licenses and filing of export information.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 22 Foreign Relations 1 2012-04-01 2012-04-01 false Filing, retention, and return of export licenses and filing of export information. 123.22 Section 123.22 Foreign Relations DEPARTMENT OF STATE INTERNATIONAL TRAFFIC IN ARMS REGULATIONS LICENSES FOR THE EXPORT OF DEFENSE ARTICLES § 123.22 Filing, retention...

22 CFR 123.22 - Filing, retention, and return of export licenses and filing of export information.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Filing, retention, and return of export licenses and filing of export information. 123.22 Section 123.22 Foreign Relations DEPARTMENT OF STATE INTERNATIONAL TRAFFIC IN ARMS REGULATIONS LICENSES FOR THE EXPORT OF DEFENSE ARTICLES § 123.22 Filing, retention...

22 CFR 123.22 - Filing, retention, and return of export licenses and filing of export information.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 22 Foreign Relations 1 2011-04-01 2011-04-01 false Filing, retention, and return of export licenses and filing of export information. 123.22 Section 123.22 Foreign Relations DEPARTMENT OF STATE INTERNATIONAL TRAFFIC IN ARMS REGULATIONS LICENSES FOR THE EXPORT OF DEFENSE ARTICLES § 123.22 Filing, retention...

22 CFR 123.22 - Filing, retention, and return of export licenses and filing of export information.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 22 Foreign Relations 1 2013-04-01 2013-04-01 false Filing, retention, and return of export licenses and filing of export information. 123.22 Section 123.22 Foreign Relations DEPARTMENT OF STATE INTERNATIONAL TRAFFIC IN ARMS REGULATIONS LICENSES FOR THE EXPORT OF DEFENSE ARTICLES § 123.22 Filing, retention...

7 CFR 800.161 - Official certificate requirements.

Code of Federal Regulations, 2010 CFR

2010-01-01

... applicable; (12) the results of the service performed; (13) the location of the issuing office; (14) the... Service shall be used for all export grain. (Approved by the Office of Management and Budget under control... STOCKYARD ADMINISTRATION (FEDERAL GRAIN INSPECTION SERVICE), DEPARTMENT OF AGRICULTURE GENERAL REGULATIONS...

7 CFR 959.18 - Export.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 8 2010-01-01 2010-01-01 false Export. 959.18 Section 959.18 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and... Handling Definitions § 959.18 Export. Export means to ship onions to any destination which is not within...

7 CFR 966.18 - Export.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 8 2010-01-01 2010-01-01 false Export. 966.18 Section 966.18 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and... Handling Definitions § 966.18 Export. Export means shipment of tomatoes beyond the boundaries of the 48...

22 CFR 123.25 - Amendments to licenses.

Code of Federal Regulations, 2011 CFR

2011-04-01

... approve an amendment to a license for permanent export, temporary export and temporary import of... Foreign Relations DEPARTMENT OF STATE INTERNATIONAL TRAFFIC IN ARMS REGULATIONS LICENSES FOR THE EXPORT OF... forwarder and the export does not involve technical data. A new license is required for these changes. Any...

22 CFR 123.25 - Amendments to licenses.

Code of Federal Regulations, 2010 CFR

2010-04-01

... approve an amendment to a license for permanent export, temporary export and temporary import of... Foreign Relations DEPARTMENT OF STATE INTERNATIONAL TRAFFIC IN ARMS REGULATIONS LICENSES FOR THE EXPORT OF... forwarder and the export does not involve technical data. A new license is required for these changes. Any...

31 CFR 549.206 - Exempt transactions.

Code of Federal Regulations, 2013 CFR

2013-07-01

... country and the exportation to any country of any information or informational materials, as defined in... authorize transactions incident to the exportation of software subject to the Export Administration Regulations, 15 CFR parts 730 through 774, or to the exportation of goods, technology, or software for use in...

31 CFR 548.206 - Exempt transactions.

Code of Federal Regulations, 2011 CFR

2011-07-01

... country and the exportation to any country of any information or informational materials, as defined in... authorize transactions incident to the exportation of software subject to the Export Administration Regulations, 15 CFR parts 730-774, or to the exportation of goods, technology, or software for use in the...

31 CFR 548.206 - Exempt transactions.

Code of Federal Regulations, 2014 CFR

2014-07-01

... country and the exportation to any country of any information or informational materials, as defined in... authorize transactions incident to the exportation of software subject to the Export Administration Regulations, 15 CFR parts 730-774, or to the exportation of goods, technology, or software for use in the...

31 CFR 549.206 - Exempt transactions.

Code of Federal Regulations, 2012 CFR

2012-07-01

... country and the exportation to any country of any information or informational materials, as defined in... authorize transactions incident to the exportation of software subject to the Export Administration Regulations, 15 CFR parts 730 through 774, or to the exportation of goods, technology, or software for use in...

31 CFR 548.206 - Exempt transactions.

Code of Federal Regulations, 2010 CFR

2010-07-01

... country and the exportation to any country of any information or informational materials, as defined in... authorize transactions incident to the exportation of software subject to the Export Administration Regulations, 15 CFR parts 730-774, or to the exportation of goods, technology, or software for use in the...

31 CFR 549.206 - Exempt transactions.

Code of Federal Regulations, 2014 CFR

2014-07-01

... country and the exportation to any country of any information or informational materials, as defined in... authorize transactions incident to the exportation of software subject to the Export Administration Regulations, 15 CFR parts 730 through 774, or to the exportation of goods, technology, or software for use in...

31 CFR 549.206 - Exempt transactions.

Code of Federal Regulations, 2011 CFR

2011-07-01

... country and the exportation to any country of any information or informational materials, as defined in... authorize transactions incident to the exportation of software subject to the Export Administration Regulations, 15 CFR parts 730 through 774, or to the exportation of goods, technology, or software for use in...

31 CFR 548.206 - Exempt transactions.

Code of Federal Regulations, 2012 CFR

2012-07-01

... country and the exportation to any country of any information or informational materials, as defined in... authorize transactions incident to the exportation of software subject to the Export Administration Regulations, 15 CFR parts 730-774, or to the exportation of goods, technology, or software for use in the...

31 CFR 548.206 - Exempt transactions.

Code of Federal Regulations, 2013 CFR

2013-07-01

... country and the exportation to any country of any information or informational materials, as defined in... authorize transactions incident to the exportation of software subject to the Export Administration Regulations, 15 CFR parts 730-774, or to the exportation of goods, technology, or software for use in the...

75 FR 20520 - Revisions to the Export Administration Regulations Based on the 2009 Missile Technology Control...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-20

... Requirements and ``items'' paragraph of ECCN 1C011 by deleting the reference to boron carbide and replacing it with boron alloys in the MT control section of this ECCN, and by making conforming changes to the MT and NS License Requirements for this ECCN. To effect this change, reference to boron alloys was...

Coupling Spatial Segregation with Synthetic Circuits to Control Bacterial Survival (Open Access)

DTIC Science & Technology

2016-02-29

Subject Categories Synthetic Biology & Biotechnology; Quantitative Biology & Dynamical Systems DOI 10.15252/msb.20156567 | Received 9 September 2015...survival. Experimentally , we program collective survival using three different gene circuits, which allow us to evaluate the modularity of the...QS-CAT circuit depends on QS regulation. The QS-BlaM circuit depends on both QS regulation and enzyme release (by lysis and export). G–I Experimental

21 CFR 1312.22 - Application for export permit.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 21 Food and Drugs 9 2010-04-01 2010-04-01 false Application for export permit. 1312.22 Section... EXPORTATION OF CONTROLLED SUBSTANCES Exportation of Controlled Substances § 1312.22 Application for export permit. (a) An application for a permit to export controlled substances shall be made on DEA Form 161...

Shoreline as a controlling factor in commercial shrimp production

NASA Technical Reports Server (NTRS)

Faller, K. H. (Principal Investigator)

1979-01-01

The author has identified the following significant results. An ecological model was developed that relates marsh detritus export and shrimp production. It was based on the hypothesis that the shoreline is a controlling factor in the production of shrimp through regulation of detritus export from the marsh. LANDSAT data were used to develop measurement of shoreline length and areas of marsh having more than 5.0 kilometers of shoreline per square kilometer of area for the Louisiana coast, demonstrating the capability of remote sensing to provide important geographic information. These factors were combined with published tidal ranges and salinities to develop a mathematical model that predicted shrimp production for nine geographic units of the Louisiana coast, as indicated by the long term average commercial shrimp yield.

15 CFR 736.2 - General prohibitions and determination of applicability.

Code of Federal Regulations, 2010 CFR

2010-01-01

..., Administrative Enforcement Proceedings. These orders prohibit many actions in addition to direct exports by the... knowledge that a violation has occurred or is about to occur (Knowledge Violation to Occur). You may not... to be exported with knowledge that a violation of the Export Administration Regulations, the Export...

22 CFR 120.17 - Export.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Export. 120.17 Section 120.17 Foreign Relations DEPARTMENT OF STATE INTERNATIONAL TRAFFIC IN ARMS REGULATIONS PURPOSE AND DEFINITIONS § 120.17 Export. (a) Export means: (1) Sending or taking a defense article out of the United States in any manner, except by...

48 CFR 52.247-51 - Evaluation of Export Offers.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false Evaluation of Export....247-51 Evaluation of Export Offers. As prescribed in 47.305-6(e), insert the following provision: Evaluation of Export Offers (JAN 2001) (a) Port handling and ocean charges—other than DOD water terminals...

48 CFR 552.211-87 - Export packing.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Export packing. 552.211-87... FORMS SOLICITATION PROVISIONS AND CONTRACT CLAUSES Text of Provisions and Clauses 552.211-87 Export packing. As prescribed in 511.204(b)(7), insert the following clause: Export Packing (JAN 2010) (a...

7 CFR 51.912 - Export.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 2 2010-01-01 2010-01-01 false Export. 51.912 Section 51.912 Agriculture Regulations... Standards for Grades of Table Grapes (European or Vinifera Type) 1 Definitions § 51.912 Export. When designated as Export, grapes shall be packed with any of the customary protective materials such as cushions...

40 CFR 211.110-3 - Export exemptions.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Export exemptions. 211.110-3 Section... PROGRAMS PRODUCT NOISE LABELING General Provisions § 211.110-3 Export exemptions. (a) A new product intended solely for export, and which has satisfied the requirements of other applicable regulations of...

22 CFR 120.17 - Export.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 22 Foreign Relations 1 2014-04-01 2014-04-01 false Export. 120.17 Section 120.17 Foreign Relations DEPARTMENT OF STATE INTERNATIONAL TRAFFIC IN ARMS REGULATIONS PURPOSE AND DEFINITIONS § 120.17 Export. (a) Export means: (1) Sending or taking a defense article out of the United States in any manner, except by...

22 CFR 120.17 - Export.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 22 Foreign Relations 1 2012-04-01 2012-04-01 false Export. 120.17 Section 120.17 Foreign Relations DEPARTMENT OF STATE INTERNATIONAL TRAFFIC IN ARMS REGULATIONS PURPOSE AND DEFINITIONS § 120.17 Export. (a) Export means: (1) Sending or taking a defense article out of the United States in any manner, except by...

22 CFR 120.17 - Export.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 22 Foreign Relations 1 2011-04-01 2011-04-01 false Export. 120.17 Section 120.17 Foreign Relations DEPARTMENT OF STATE INTERNATIONAL TRAFFIC IN ARMS REGULATIONS PURPOSE AND DEFINITIONS § 120.17 Export. (a) Export means: (1) Sending or taking a defense article out of the United States in any manner, except by...

22 CFR 120.17 - Export.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 22 Foreign Relations 1 2013-04-01 2013-04-01 false Export. 120.17 Section 120.17 Foreign Relations DEPARTMENT OF STATE INTERNATIONAL TRAFFIC IN ARMS REGULATIONS PURPOSE AND DEFINITIONS § 120.17 Export. (a) Export means: (1) Sending or taking a defense article out of the United States in any manner, except by...

50 CFR 300.185 - Documentation, reporting and recordkeeping requirements for consignment documents and re-export...

Code of Federal Regulations, 2011 CFR

2011-10-01

.... (3) Reporting requirements. For fish or fish products regulated under this subpart, except shark fins... this paragraph (b) apply to exports of fish or fish products regulated under this subpart, except shark... consignment of fish or fish products regulated under this subpart, except bluefin tuna or shark fins, that was...

Regulation of stream water dissolved organic carbon concentrations ([DOC]) during snowmelt in forest streams; the role of discharge, winter climate and memory effects

NASA Astrophysics Data System (ADS)

Ågren, A.; Haei, M.; Öquist, M.; Buffam, I.; Ottosson-Löfvenius, M.; Kohler, S.; Bishop, K.; Blomkvist, P.; Laudon, H.

2011-12-01

Using 15 year stream records from two forested northern boreal catchments, coupled with soil frost experiments in the riparian zone, we demonstrate the complex inter-annual control on [DOC] and export during snowmelt. Stream [DOC] varied by a factor of 2 during those 15 years with no consistent trend. Based on our long-term analysis, we demonstrate, for the first time, that stream water [DOC] is strongly linked to the climatic conditions during the preceding winter, but that there is also a long-term memory effect in the catchment soils, related to the extent of the previous export from the catchment. Hydrology had a first order control on the inter-annual variation in concentrations, and the length of the winter was more important than the memory effect. By removing the effect of discharge on [DOC], using a conceptual hydrological model, we could detect processes that would otherwise have been overshadowed. A short and intense snowmelt gave higher [DOC] in the stream. During a prolonged snowmelt, one soil layer at the time might have been "flushed" from easily exported DOC, resulting in slightly lower stream [DOC] during such years. We found that longer and colder winters resulted in higher [DOC] during the subsequent snowmelt. A soil frost manipulation experiment in the riparian soils of the study catchment showed that the DOC concentrations in the soil water increased with the duration of the soil frost. A high antecedent DOC export during the preceding summer and autumn resulted in lower concentrations during the following spring, indicating a long-term "memory effect" of the catchment soils. In a nearby stream draining mire, we found a different response to hydrology but similar response to climate and memory effect. The inter-annual variation in snowmelt DOC exports was mostly controlled by the amount of runoff, but the variability in [DOC] also exerted a significant control on the exports, accounting for 15% of the variance in exports. We conclude that winter climatic conditions can play a substantial role in controlling stream [DOC] in ways not previously understood. These findings are especially important for northern latitude regions expected to be most affected by climate change. It's difficult to directly translate this to a future climate change prediction. If warmer winters with less insulating snow cover increase the soil frost, the results from the soil frost manipulation experiment then suggest increasing [DOC] in a future climate. At the same time the statistical analysis of the stream records suggest that a shorter and warmer winter would decrease the [DOC]. Our results do, however, highlight the role of winter climate for regulating DOC in areas with seasonally frozen soils which should be considered when resolving the sensitivity of stream [DOC] to global environmental change.

77 FR 35310 - Revisions to the Export Administration Regulations (EAR): Control of Military Training Equipment...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-13

... Classification Numbers (ECCNs) 0A614, 0B614, 0D614, and 0E614. This rule is one in a planned series of proposed... that is, as a result of differences in form and fit, ``specially designed'' for military applications...

Voice of Experience International Research Infrastructure and the Impact of Export Control Regulations

ERIC Educational Resources Information Center

Kulakowski, Elliott C.; Chronister, Lynne; Molfese, Victoria; Slocum, Michael; Studman, Cliff; Waugaman, Paul

2007-01-01

Research today has become very complex, often involving international collaborations among multidisciplinary teams. Many institutions, especially those in less economically developed countries, have a great deal of expertise to contribute to these collaborations, but often lack the instrumentation, training, and research management infrastructure…

Sensitivity of the quarantine pest rough sweetpotato weevil, Blosyrus asellus to postharvest irradiation treatment

USDA-ARS?s Scientific Manuscript database

Rough sweetpotato weevil, Blosyrus asellus (Olivier), is a new quarantine pest of Hawaii sweetpotatoes. Currently, sweetpotatoes can be exported from Hawaii to the U.S. mainland using a postharvest irradiation treatment of 150 Gy to control three other regulated insect pests. Studies were conducted...

A novel mechanism of E2F1 regulation via nucleocytoplasmic shuttling: determinants of nuclear import and export.

PubMed

Ivanova, Iordanka A; Vespa, Alisa; Dagnino, Lina

2007-09-01

E2F1 is a transcription factor central for cell survival, proliferation, and repair following genomic insult. Depending on the cell type and conditions, E2F1 can induce apoptosis in transformed cells, behaving as a tumour suppressor, or impart growth advantages favouring tumour formation. The pleiotropic functions of E2F1 are a likely consequence of its ability to transcriptionally control a wide variety of target genes, and require tight regulation of its activity at multiple levels. Although sequestration of proteins to particular cellular compartments is a well-established regulatory mechanism, virtually nothing is known about its contribution to modulation of E2F1 target gene expression. We have examined the subcellular trafficking of E2F1 and, contrary to the widely held notion that this factor is constitutively nuclear, we now demonstrate that it is subjected to continuous nucleocytoplasmic shuttling. We have also defined two nuclear localization domains and a nuclear export region, which mediates CRM1-dependent transit out of the nucleus. The predominant subcellular location of E2F1 is likely determined by the balance between the activity of nuclear import and export domains, and can be modulated by differentiation stimuli in epidermal cells. Thus, we have identified a hitherto unrecognized mechanism to control E2F1 function through modulation of its subcellular localization.

The nucleolus directly regulates p53 export and degradation.

PubMed

Boyd, Mark T; Vlatkovic, Nikolina; Rubbi, Carlos P

2011-09-05

The correlation between stress-induced nucleolar disruption and abrogation of p53 degradation is evident after a wide variety of cellular stresses. This link may be caused by steps in p53 regulation occurring in nucleoli, as suggested by some biochemical evidence. Alternatively, nucleolar disruption also causes redistribution of nucleolar proteins, potentially altering their interactions with p53 and/or MDM2. This raises the fundamental question of whether the nucleolus controls p53 directly, i.e., as a site where p53 regulatory processes occur, or indirectly, i.e., by determining the cellular localization of p53/MDM2-interacting factors. In this work, transport experiments based on heterokaryons, photobleaching, and micronucleation demonstrate that p53 regulatory events are directly regulated by nucleoli and are dependent on intact nucleolar structure and function. Subcellular fractionation and nucleolar isolation revealed a distribution of ubiquitylated p53 that supports these findings. In addition, our results indicate that p53 is exported by two pathways: one stress sensitive and one stress insensitive, the latter being regulated by activities present in the nucleolus.

22 CFR 123.1 - Requirement for export or temporary import licenses.

Code of Federal Regulations, 2014 CFR

2014-04-01

... licenses. 123.1 Section 123.1 Foreign Relations DEPARTMENT OF STATE INTERNATIONAL TRAFFIC IN ARMS REGULATIONS LICENSES FOR THE EXPORT AND TEMPORARY IMPORT OF DEFENSE ARTICLES § 123.1 Requirement for export or temporary import licenses. (a) Any person who intends to export or to import temporarily a defense article...

15 CFR 1300.1 - Reporting of exports of technology to nonmarket economy countries.

Code of Federal Regulations, 2012 CFR

2012-01-01

... nonmarket economy countries. 1300.1 Section 1300.1 Commerce and Foreign Trade Regulations Relating to... § 1300.1 Reporting of exports of technology to nonmarket economy countries. (a) For purposes of complying... the export of technology to a nonmarket economy country, exporters of such technology shall be deemed...

15 CFR 1300.1 - Reporting of exports of technology to nonmarket economy countries.

Code of Federal Regulations, 2011 CFR

2011-01-01

... nonmarket economy countries. 1300.1 Section 1300.1 Commerce and Foreign Trade Regulations Relating to... § 1300.1 Reporting of exports of technology to nonmarket economy countries. (a) For purposes of complying... the export of technology to a nonmarket economy country, exporters of such technology shall be deemed...

15 CFR 1300.1 - Reporting of exports of technology to nonmarket economy countries.

Code of Federal Regulations, 2013 CFR

2013-01-01

... nonmarket economy countries. 1300.1 Section 1300.1 Commerce and Foreign Trade Regulations Relating to... § 1300.1 Reporting of exports of technology to nonmarket economy countries. (a) For purposes of complying... the export of technology to a nonmarket economy country, exporters of such technology shall be deemed...

37 CFR 5.20 - Export of technical data relating to sensitive nuclear technology.

Code of Federal Regulations, 2011 CFR

2011-07-01

... relating to sensitive nuclear technology. 5.20 Section 5.20 Patents, Trademarks, and Copyrights UNITED... LICENSES TO EXPORT AND FILE APPLICATIONS IN FOREIGN COUNTRIES Licenses for Foreign Exporting and Filing § 5.20 Export of technical data relating to sensitive nuclear technology. Under regulations (10 CFR 810.7...

37 CFR 5.20 - Export of technical data relating to sensitive nuclear technology.

Code of Federal Regulations, 2010 CFR

2010-07-01

... relating to sensitive nuclear technology. 5.20 Section 5.20 Patents, Trademarks, and Copyrights UNITED... LICENSES TO EXPORT AND FILE APPLICATIONS IN FOREIGN COUNTRIES Licenses for Foreign Exporting and Filing § 5.20 Export of technical data relating to sensitive nuclear technology. Under regulations (10 CFR 810.7...

40 CFR 90.909 - Export exemptions.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 20 2010-07-01 2010-07-01 false Export exemptions. 90.909 Section 90... of Nonroad Engines from Regulations § 90.909 Export exemptions. (a) A new nonroad engine intended solely for export, and so labeled or tagged on the outside of the container and on the engine itself, is...

22 CFR 120.30 - The Automated Export System (AES).

Code of Federal Regulations, 2012 CFR

2012-04-01

... 22 Foreign Relations 1 2012-04-01 2012-04-01 false The Automated Export System (AES). 120.30 Section 120.30 Foreign Relations DEPARTMENT OF STATE INTERNATIONAL TRAFFIC IN ARMS REGULATIONS PURPOSE AND DEFINITIONS § 120.30 The Automated Export System (AES). The Automated Export System (AES) is the Department of...

22 CFR 120.30 - The Automated Export System (AES).

Code of Federal Regulations, 2014 CFR

2014-04-01

... 22 Foreign Relations 1 2014-04-01 2014-04-01 false The Automated Export System (AES). 120.30 Section 120.30 Foreign Relations DEPARTMENT OF STATE INTERNATIONAL TRAFFIC IN ARMS REGULATIONS PURPOSE AND DEFINITIONS § 120.30 The Automated Export System (AES). The Automated Export System (AES) is the Department of...

22 CFR 120.30 - The Automated Export System (AES).

Code of Federal Regulations, 2011 CFR

2011-04-01

... 22 Foreign Relations 1 2011-04-01 2011-04-01 false The Automated Export System (AES). 120.30 Section 120.30 Foreign Relations DEPARTMENT OF STATE INTERNATIONAL TRAFFIC IN ARMS REGULATIONS PURPOSE AND DEFINITIONS § 120.30 The Automated Export System (AES). The Automated Export System (AES) is the Department of...

22 CFR 120.30 - The Automated Export System (AES).

Code of Federal Regulations, 2013 CFR

2013-04-01

... 22 Foreign Relations 1 2013-04-01 2013-04-01 false The Automated Export System (AES). 120.30 Section 120.30 Foreign Relations DEPARTMENT OF STATE INTERNATIONAL TRAFFIC IN ARMS REGULATIONS PURPOSE AND DEFINITIONS § 120.30 The Automated Export System (AES). The Automated Export System (AES) is the Department of...

SR proteins are NXF1 adaptors that link alternative RNA processing to mRNA export

PubMed Central

Müller-McNicoll, Michaela; Botti, Valentina; de Jesus Domingues, Antonio M.; Brandl, Holger; Schwich, Oliver D.; Steiner, Michaela C.; Curk, Tomaz; Poser, Ina; Zarnack, Kathi; Neugebauer, Karla M.

2016-01-01

Nuclear export factor 1 (NXF1) exports mRNA to the cytoplasm after recruitment to mRNA by specific adaptor proteins. How and why cells use numerous different export adaptors is poorly understood. Here we critically evaluate members of the SR protein family (SRSF1–7) for their potential to act as NXF1 adaptors that couple pre-mRNA processing to mRNA export. Consistent with this proposal, >1000 endogenous mRNAs required individual SR proteins for nuclear export in vivo. To address the mechanism, transcriptome-wide RNA-binding profiles of NXF1 and SRSF1–7 were determined in parallel by individual-nucleotide-resolution UV cross-linking and immunoprecipitation (iCLIP). Quantitative comparisons of RNA-binding sites showed that NXF1 and SR proteins bind mRNA targets at adjacent sites, indicative of cobinding. SRSF3 emerged as the most potent NXF1 adaptor, conferring sequence specificity to RNA binding by NXF1 in last exons. Interestingly, SRSF3 and SRSF7 were shown to bind different sites in last exons and regulate 3′ untranslated region length in an opposing manner. Both SRSF3 and SRSF7 promoted NXF1 recruitment to mRNA. Thus, SRSF3 and SRSF7 couple alternative splicing and polyadenylation to NXF1-mediated mRNA export, thereby controlling the cytoplasmic abundance of transcripts with alternative 3′ ends. PMID:26944680

21 CFR 1310.09 - Temporary exemption from registration.

Code of Federal Regulations, 2010 CFR

2010-04-01

... manufacture, distribute, import, or export regulated iodine, including regulated iodine chemical mixtures... a chemical mixture containing iodine on or before August 31, 2007. The exemption will remain in... distributes, imports, or exports a chemical mixture containing iodine whose application for exemption is...

77 FR 33688 - Revisions to the Export Administration Regulations (EAR): Control of Personal Protective...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-07

... would remove machetes from ECCN 0A988. This is one in a planned series of proposed rules describing how... nonetheless a type of article that is, as a result of differences in form and fit, ``specially designed'' for... proposed creating a series of new ECCNs to control items that would be removed from the USML, or that are...

Lysosomal Physiology

PubMed Central

Xu, Haoxing; Ren, Dejian

2015-01-01

Lysosomes are acidic compartments filled with more than 60 different types of hydrolases. They mediate the degradation of extracellular particles from endocytosis and of intracellular components from autophagy. The digested products are transported out of the lysosome via specific catabolite exporters or via vesicular membrane trafficking. Lysosomes also contain more than 50 membrane proteins and are equipped with the machinery to sense nutrient availability, which determines the distribution, number, size, and activity of lysosomes to control the specificity of cargo flux and timing (the initiation and termination) of degradation. Defects in degradation, export, or trafficking result in lysosomal dysfunction and lysosomal storage diseases (LSDs). Lysosomal channels and transporters mediate ion flux across perimeter membranes to regulate lysosomal ion homeostasis, membrane potential, catabolite export, membrane trafficking, and nutrient sensing. Dysregulation of lysosomal channels underlies the pathogenesis of many LSDs and possibly that of metabolic and common neurodegenerative diseases. PMID:25668017

Infrared Imaging Camera Final Report CRADA No. TC02061.0

DOE Office of Scientific and Technical Information (OSTI.GOV)

Roos, E. V.; Nebeker, S.

This was a collaborative effort between the University of California, Lawrence Livermore National Laboratory (LLNL) and Cordin Company (Cordin) to enhance the U.S. ability to develop a commercial infrared camera capable of capturing high-resolution images in a l 00 nanoseconds (ns) time frame. The Department of Energy (DOE), under an Initiative for Proliferation Prevention (IPP) project, funded the Russian Federation Nuclear Center All-Russian Scientific Institute of Experimental Physics (RFNC-VNIIEF) in Sarov. VNIIEF was funded to develop a prototype commercial infrared (IR) framing camera and to deliver a prototype IR camera to LLNL. LLNL and Cordin were partners with VNIIEF onmore » this project. A prototype IR camera was delivered by VNIIEF to LLNL in December 2006. In June of 2007, LLNL and Cordin evaluated the camera and the test results revealed that the camera exceeded presently available commercial IR cameras. Cordin believes that the camera can be sold on the international market. The camera is currently being used as a scientific tool within Russian nuclear centers. This project was originally designated as a two year project. The project was not started on time due to changes in the IPP project funding conditions; the project funding was re-directed through the International Science and Technology Center (ISTC), which delayed the project start by over one year. The project was not completed on schedule due to changes within the Russian government export regulations. These changes were directed by Export Control regulations on the export of high technology items that can be used to develop military weapons. The IR camera was on the list that export controls required. The ISTC and Russian government, after negotiations, allowed the delivery of the camera to LLNL. There were no significant technical or business changes to the original project.« less

76 FR 18995 - Pesticides; Regulation to Clarify Labeling of Pesticides for Export

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-06

... this proposed rule will not have disproportionately high and adverse human health or environmental... for all affected populations without having any disproportionately high and adverse human health or... Pesticides; Regulation to Clarify Labeling of Pesticides for Export AGENCY: Environmental Protection Agency...

75 FR 18471 - Notice of Request for Renewal of a Recordkeeping Burden

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-12

... covering exports of apples and grapes. DATES: Comments on this notice must be received by June 11, 2010 to...: Export Fruit Regulations--Export Apple Act (7 CFR part 33) and the Export Grape and Plum Act (7 CFR part... for Renewal of a Recordkeeping Burden. Abstract: Fresh apples and grapes grown in the United States...

78 FR 23736 - Notice of Request for Renewal of a Recordkeeping Burden

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-22

... covering exports of apples and grapes. DATES: Comments on this notice are due by June 21, 2013 to be... INFORMATION: Title: Export Fruit Regulations--Export Apple Act (7 CFR part 33) and the Export Grape and Plum... Request: Request for Renewal of a Recordkeeping Burden. Abstract: Fresh apples and grapes grown in the...

Substitution and the USDA Forest Service log export restrictions.

Treesearch

Gary R. Lindell

1980-01-01

With some exceptions, the substitution of national forest timber for exported private timber is forbidden by regulations. Certain firms may use a limited amount of national forest timber as replacement for exported private timber, however, in accordance with their pattern of purchases and exports from 1971 through 1973. About 359 million board feet of national forest...

15 CFR 745.1 - Advance notification and annual report of all exports of Schedule 1 chemicals to other States...

Code of Federal Regulations, 2011 CFR

2011-01-01

... SECURITY, DEPARTMENT OF COMMERCE EXPORT ADMINISTRATION REGULATIONS CHEMICAL WEAPONS CONVENTION REQUIREMENTS... Prohibition of Chemical Weapons (OPCW) not less than 30 days in advance of every export of a Schedule 1... of all exports of Schedule 1 chemicals to other States Parties. 745.1 Section 745.1 Commerce and...

Regulation of NT-PGC-1alpha subcellular localization and function by protein kinase A-dependent modulation of nuclear export by CRM1.

PubMed

Chang, Ji Suk; Huypens, Peter; Zhang, Yubin; Black, Chelsea; Kralli, Anastasia; Gettys, Thomas W

2010-06-04

Peroxisome proliferator-activated receptor gamma co-activator-1alpha (PGC-1alpha) plays a central role in the regulation of cellular energy metabolism and metabolic adaptation to environmental and nutritional stimuli. We recently described a novel, biologically active splice variant of PGC-1alpha (NT-PGC-1alpha, amino acids 1-270) that retains the ability to interact with and transactivate nuclear hormone receptors through its N-terminal transactivation domain. Whereas PGC-1alpha is an unstable nuclear protein sensitive to ubiquitin-mediated targeting to the proteasome, NT-PGC-1alpha is relatively stable and predominantly cytoplasmic, suggesting that its ability to interact with and activate nuclear receptors and transcription factors is dependent upon regulated access to the nucleus. We provide evidence that NT-PGC-1alpha interacts with the nuclear exportin, CRM1, through a specific leucine-rich domain (nuclear export sequence) that regulates its export to the cytoplasm. The nuclear export of NT-PGC-1alpha is inhibited by protein kinase A-dependent phosphorylation of Ser-194, Ser-241, and Thr-256 on NT-PGC-1alpha, which effectively increases its nuclear concentration. Using site-directed mutagenesis to prevent or mimic phosphorylation at these sites, we show that the transcriptional activity of NT-PGC-1alpha is regulated in part through regulation of its subcellular localization. These findings suggest that the function of NT-PGC-1alpha as a transcriptional co-activator is regulated by protein kinase A-dependent inhibition of CRM1-mediated export from the nucleus.

7 CFR 1493.220 - Exporter eligibility.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 7 Agriculture 10 2011-01-01 2011-01-01 false Exporter eligibility. 1493.220 Section 1493.220 Agriculture Regulations of the Department of Agriculture (Continued) COMMODITY CREDIT CORPORATION, DEPARTMENT OF AGRICULTURE LOANS, PURCHASES, AND OTHER OPERATIONS CCC EXPORT CREDIT GUARANTEE PROGRAMS CCC...

7 CFR 1493.220 - Exporter eligibility.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 10 2010-01-01 2010-01-01 false Exporter eligibility. 1493.220 Section 1493.220 Agriculture Regulations of the Department of Agriculture (Continued) COMMODITY CREDIT CORPORATION, DEPARTMENT OF AGRICULTURE LOANS, PURCHASES, AND OTHER OPERATIONS CCC EXPORT CREDIT GUARANTEE PROGRAMS CCC...

Chemical Genetics of 14-3-3 Regulation and Role in Tumor Development

DTIC Science & Technology

2005-11-01

inhibitors , our group had identified a series of inhibitory compounds. When tested one of these, TK10, shows an inhibitory effect on 14-3-3 sigma nuclear...potential regulators of 14-3-3 sigma function. 5 BODY Determine the biological activity of the newly identified inhibitor of 14-3- &T nuclear export TKI0 I...have previously shown that an inhibitor of FOXOla nuclear export, TK10, inhibits the export of 14- 3-3 from the nucleus while TK10 does not affect

7 CFR 35.12 - Inspection and certification.

Code of Federal Regulations, 2011 CFR

2011-01-01

... REGULATIONS EXPORT GRAPES AND PLUMS Regulations § 35.12 Inspection and certification. (a) Each person shipping or offering for shipment any variety of vinifera species table grapes, to any foreign destination... “Meets requirements of Export Grape and Plum Act” or (2) For any variety meeting specifications of...

32 CFR 250.7 - Pertinent portions of Export Administration Regulations (EAR).

Code of Federal Regulations, 2010 CFR

2010-07-01

... form, including (1) Data released orally or visually at open conferences, lectures, trade show, or... SECRETARY OF DEFENSE (CONTINUED) MISCELLANEOUS WITHHOLDING OF UNCLASSIFIED TECHNICAL DATA FROM PUBLIC... technical data under the authority of this part. Export Administration Regulations 15 CFR 379.3 General...

32 CFR 250.7 - Pertinent portions of Export Administration Regulations (EAR).

Code of Federal Regulations, 2011 CFR

2011-07-01

... form, including (1) Data released orally or visually at open conferences, lectures, trade show, or... SECRETARY OF DEFENSE (CONTINUED) MISCELLANEOUS WITHHOLDING OF UNCLASSIFIED TECHNICAL DATA FROM PUBLIC... technical data under the authority of this part. Export Administration Regulations 15 CFR 379.3 General...

32 CFR 250.7 - Pertinent portions of Export Administration Regulations (EAR).

Code of Federal Regulations, 2013 CFR

2013-07-01

... form, including (1) Data released orally or visually at open conferences, lectures, trade show, or... SECRETARY OF DEFENSE (CONTINUED) MISCELLANEOUS WITHHOLDING OF UNCLASSIFIED TECHNICAL DATA FROM PUBLIC... technical data under the authority of this part. Export Administration Regulations 15 CFR 379.3 General...

7 CFR 51.321 - U.S. Condition Standards for Export. 4

Code of Federal Regulations, 2013 CFR

2013-01-01

... 7 Agriculture 2 2013-01-01 2013-01-01 false U.S. Condition Standards for Export. 4 51.321 Section 51.321 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE REGULATIONS AND STANDARDS UNDER THE...

7 CFR 51.321 - U.S. Condition Standards for Export. 4

Code of Federal Regulations, 2014 CFR

2014-01-01

... 7 Agriculture 2 2014-01-01 2014-01-01 false U.S. Condition Standards for Export. 4 51.321 Section 51.321 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE REGULATIONS AND STANDARDS UNDER THE...

7 CFR 51.321 - U.S. Condition Standards for Export. 4

Code of Federal Regulations, 2012 CFR

2012-01-01

... 7 Agriculture 2 2012-01-01 2012-01-01 false U.S. Condition Standards for Export. 4 51.321 Section 51.321 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE REGULATIONS AND STANDARDS UNDER THE...

7 CFR 51.321 - U.S. Condition Standards for Export. 4

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 2 2010-01-01 2010-01-01 false U.S. Condition Standards for Export. 4 51.321 Section 51.321 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE REGULATIONS AND STANDARDS UNDER THE...

7 CFR 51.321 - U.S. Condition Standards for Export. 4

Code of Federal Regulations, 2011 CFR

2011-01-01

... 7 Agriculture 2 2011-01-01 2011-01-01 false U.S. Condition Standards for Export. 4 51.321 Section 51.321 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE REGULATIONS AND STANDARDS UNDER THE...

31 CFR 505.10 - Prohibitions.

Code of Federal Regulations, 2010 CFR

2010-07-01

... United States is prohibited by regulations issued under the Arms Export Control Act of 1976, 22 U.S.C. 2778, or the Atomic Energy Act of 1954, 42 U.S.C. 2011-2297g-4, or successor acts restricting the... North Korea Mongolia People's Republic of China Poland Romania The Slovak Republic The geographic area...

77 FR 55183 - Effects of Foreign Policy-Based Export Controls

Federal Register 2010, 2011, 2012, 2013, 2014

2012-09-07

... or on paper to Regulatory Policy Division, Bureau of Industry and Security, Department of Commerce... Comment'' in the subject line of the email message or on the envelope if submitting comments on paper. All comments must be in writing (either submitted to regulations.gov , by email or on paper). All comments...

LISLEX: Legal Issues of Concern to the Library and Information Sector.

ERIC Educational Resources Information Center

Oppenheim, Charles

1998-01-01

Examines paparazzi and copyright law, regulation of the Internet, the European Union Database Directive and U.S. efforts to change database laws, Tasini v. The New York Times, freedom of information and access to public sector information, company law and e-mail messages, electronic commerce, cryptography export controls, domain names and trade…

76 FR 41957 - Proposed Revisions to the Export Administration Regulations (EAR): Control of Items the President...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-15

... made eligible for License Exception Strategic Trade Authorization (STA), and proposes EAR amendments... Arrangement Munitions List items on the CCL. (B) Addition of license review policy for ``600 series'' items for National Security (NS) and Regional Stability (RS) reasons. (C) License Exceptions for ``600...

75 FR 52625 - Amendment to the International Traffic in Arms Regulations: Export Exemption for Technical Data

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-27

... the provisions of the Department of Defense National Industrial Security Program Operating Manual, an... Department of Defense National Industrial Security Program Operating Manual (unless such requirements are in..., Arms Control and International Security, Department of State. [FR Doc. 2010-21450 Filed 8-26-10; 8:45...

22 CFR 120.8 - Major defense equipment.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 22 Foreign Relations 1 2011-04-01 2011-04-01 false Major defense equipment. 120.8 Section 120.8 Foreign Relations DEPARTMENT OF STATE INTERNATIONAL TRAFFIC IN ARMS REGULATIONS PURPOSE AND DEFINITIONS § 120.8 Major defense equipment. Pursuant to section 47(6) of the Arms Export Control Act (22 U.S.C...

22 CFR 120.8 - Major defense equipment.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 22 Foreign Relations 1 2014-04-01 2014-04-01 false Major defense equipment. 120.8 Section 120.8 Foreign Relations DEPARTMENT OF STATE INTERNATIONAL TRAFFIC IN ARMS REGULATIONS PURPOSE AND DEFINITIONS § 120.8 Major defense equipment. Pursuant to section 47(6) of the Arms Export Control Act (22 U.S.C...

22 CFR 120.8 - Major defense equipment.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 22 Foreign Relations 1 2013-04-01 2013-04-01 false Major defense equipment. 120.8 Section 120.8 Foreign Relations DEPARTMENT OF STATE INTERNATIONAL TRAFFIC IN ARMS REGULATIONS PURPOSE AND DEFINITIONS § 120.8 Major defense equipment. Pursuant to section 47(6) of the Arms Export Control Act (22 U.S.C...

22 CFR 120.8 - Major defense equipment.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 22 Foreign Relations 1 2012-04-01 2012-04-01 false Major defense equipment. 120.8 Section 120.8 Foreign Relations DEPARTMENT OF STATE INTERNATIONAL TRAFFIC IN ARMS REGULATIONS PURPOSE AND DEFINITIONS § 120.8 Major defense equipment. Pursuant to section 47(6) of the Arms Export Control Act (22 U.S.C...

22 CFR 120.2 - Designation of defense articles and defense services.

Code of Federal Regulations, 2014 CFR

2014-04-01

... services. 120.2 Section 120.2 Foreign Relations DEPARTMENT OF STATE INTERNATIONAL TRAFFIC IN ARMS REGULATIONS PURPOSE AND DEFINITIONS § 120.2 Designation of defense articles and defense services. The Arms... changed only by amendments made pursuant to section 38 of the Arms Export Control Act (22 U.S.C. 2778...

78 FR 76741 - Revisions to the Export Administration Regulations (EAR): Unverified List (UVL)

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-19

... of Defense Trade Controls of the Department of State by: Precluding access to; refusing to provide... DEPARTMENT OF COMMERCE Bureau of Industry and Security 15 CFR Parts 730, 740, 744, 756, 758, and..., Bureau of Industry and Security, Department of Commerce, Phone: (202) 482-2385 or by email at Kevin...

22 CFR 123.9 - Country of ultimate destination and approval of reexports or retransfers.

Code of Federal Regulations, 2013 CFR

2013-04-01

... ARMS REGULATIONS LICENSES FOR THE EXPORT OF DEFENSE ARTICLES § 123.9 Country of ultimate destination... the Directorate of Defense Trade Controls must be obtained before reselling, transferring, reexporting, retransferring, transshipping, or disposing of a defense article to any end-user, end-use, or destination other...

22 CFR 123.9 - Country of ultimate destination and approval of reexports or retransfers.

Code of Federal Regulations, 2011 CFR

2011-04-01

... ARMS REGULATIONS LICENSES FOR THE EXPORT OF DEFENSE ARTICLES § 123.9 Country of ultimate destination... the Directorate of Defense Trade Controls must be obtained before reselling, transferring, transshipping, or disposing of a defense article to any end user, end use or destination other than as stated on...

15 CFR Supplement No. 4 to Part 744 - Entity List

Code of Federal Regulations, 2014 CFR

2014-01-01

...) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE EXPORT ADMINISTRATION REGULATIONS CONTROL POLICY... the EAR. (See § 744.11 of the EAR). Presumption of denial 77 FR 25057, 4/27/12. Zurmat Group of... Electronic Solutions, a.k.a., the following one alias:—Mercury Group International, 380 Vansickle Rd Unit 660...

15 CFR Supplement No. 4 to Part 744 - Entity List

Code of Federal Regulations, 2013 CFR

2013-01-01

...) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE EXPORT ADMINISTRATION REGULATIONS CONTROL POLICY... the EAR. (See § 744.11 of the EAR). Presumption of denial 77 FR 25057, 4/27/12. Zurmat Group of... Group International, 380 Vansickle Rd Unit 660, St. Catharines, ON L2126P7, Canada; and 127 Rue Wilson...

Guide to investment and trade in the forest-product sectors of Southeast Asia: Indonesia, Malaysia, and the Philippines. Working paper

DOE Office of Scientific and Technical Information (OSTI.GOV)

Krutilia, K.

1988-01-01

Declining timber resources, an increase in value-added wood-base processing, new export markets, and a growing stress on joint ventures have been key factors in the rapid evolution since 1975 of Southeast Asia's forest products industry. The report profiles the industry and its prospects in Indonesia, the Philippines, and Malaysia, each of which differs with respect to stage of wood-industry development and investment climate. The countries' forest management policies, timber resources, and the status of their wood-based processing industries are reviewed first, followed by an overview of the business environment in each country, the latter covering policies toward foreign investment (includingmore » the increasingly important investments from other less-developed countries), investment licensing and regulation, taxation, exporting/importing regulations, and policies governing currency and capital controls. Includes a 5-page list of references and a short annotated bibliography.« less

15 CFR 30.9 - Transmitting and correcting Electronic Export Information.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 15 Commerce and Foreign Trade 1 2010-01-01 2010-01-01 false Transmitting and correcting Electronic Export Information. 30.9 Section 30.9 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade BUREAU OF THE CENSUS, DEPARTMENT OF COMMERCE FOREIGN TRADE REGULATIONS General Requirements...

45 CFR 670.32 - Specific issuance criteria for exports.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 45 Public Welfare 3 2010-10-01 2010-10-01 false Specific issuance criteria for exports. 670.32 Section 670.32 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL SCIENCE... would be consistent with the purposes of the Act, the regulations in this part, or the permit under...

50 CFR 300.183 - Permit holder reporting and recordkeeping requirements.

Code of Federal Regulations, 2011 CFR

2011-10-01

... information for each consignment of fish or fish products regulated under this subpart, except shark fins... biweekly report of entries for consumption, exports and re-exports of fish and fish products regulated under this subpart except shark fins. (1) The report required to be submitted under this paragraph (a...

75 FR 842 - Action Affecting Export Privileges: Hailin Lin

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-06

... DEPARTMENT OF COMMERCE Bureau of Industry and Security Action Affecting Export Privileges: Hailin... Regulations. Charges 112-12415: CFR 764.2(h)--Taking Action With Intent To Evade the Regulations In connection... through on or about September 30, 2004, Lin took actions with intent to evade the provisions of the...

75 FR 337 - Action Affecting Export Privileges: Ning Wen

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-05

... DEPARTMENT OF COMMERCE Bureau of Industry and Security [07-BIS-02] Action Affecting Export.... Charges 112-124: 15 CFR 764.2(h)--Taking Action With Intent To Evade the Regulations In connection with... or about September 30, 2004, Wen took actions with intent to evade the provisions of the Regulations...

77 FR 42973 - Export and Reexport Controls to Rwanda and United Nations Sanctions Under the Export...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-23

... Control List), Category 0--Nuclear Materials, Facilities, and Equipment [and Miscellaneous Items]--Export... Control List), Category 0--Nuclear Materials, Facilities, and Equipment [and Miscellaneous Items]--Export... Supplement No. 1 to Part 774 (the Commerce Control List), Category 0--Nuclear Materials, Facilities, and...

76 FR 12371 - Agency Information Collection Activities: Proposed Collection; Comments Requested: Application...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-07

... Controlled Substances/Export Controlled Substances for Re-Export--DEA Forms 161 and 161r ACTION: 60-Day... Administration (DEA), will submit the following information collection request to the Office of Management and...: Application for Permit to Export Controlled Substances/Export Controlled Substances for Reexport--DEA Forms...

15 CFR 1300.1 - Reporting of exports of technology to nonmarket economy countries.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 15 Commerce and Foreign Trade 3 2010-01-01 2010-01-01 false Reporting of exports of technology to nonmarket economy countries. 1300.1 Section 1300.1 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) EAST-WEST FOREIGN TRADE BOARD REPORTS ON EXPORTS OF TECHNOLOGY § 1300.1 Reporting of exports of technology t...

15 CFR 744.7 - Restrictions on certain exports to and for the use of certain foreign vessels or aircraft.

Code of Federal Regulations, 2012 CFR

2012-01-01

... Export System (AES) record is filed in accordance with the requirements of the Foreign Trade Statistics Regulations (15 CFR part 30), except that an SED or AES record is not required when any of the commodities... as cargo for which a Shipper's Export Declaration (SED) or Automated Export System (AES) record is...

15 CFR 744.7 - Restrictions on certain exports to and for the use of certain foreign vessels or aircraft.

Code of Federal Regulations, 2013 CFR

2013-01-01

... Export System (AES) record is filed in accordance with the requirements of the Foreign Trade Statistics Regulations (15 CFR part 30), except that an SED or AES record is not required when any of the commodities... as cargo for which a Shipper's Export Declaration (SED) or Automated Export System (AES) record is...

15 CFR 744.7 - Restrictions on certain exports to and for the use of certain foreign vessels or aircraft.

Code of Federal Regulations, 2014 CFR

2014-01-01

... Export System (AES) record is filed in accordance with the requirements of the Foreign Trade Statistics Regulations (15 CFR part 30), except that an SED or AES record is not required when any of the commodities... as cargo for which a Shipper's Export Declaration (SED) or Automated Export System (AES) record is...

15 CFR 744.7 - Restrictions on certain exports to and for the use of certain foreign vessels or aircraft.

Code of Federal Regulations, 2011 CFR

2011-01-01

... Export System (AES) record is filed in accordance with the requirements of the Foreign Trade Statistics Regulations (15 CFR part 30), except that an SED or AES record is not required when any of the commodities... as cargo for which a Shipper's Export Declaration (SED) or Automated Export System (AES) record is...

Magnitude of the Freshwater Turtle Exports from the US: Long Term Trends and Early Effects of Newly Implemented Harvest Management Regimes

PubMed Central

Mali, Ivana; Vandewege, Michael W.; Davis, Scott K.; Forstner, Michael R. J.

2014-01-01

Unregulated commercial harvest remains a major threat for turtles across the globe. Due to continuing demand from Asian markets, a significant number of turtles are exported from the United States of America (US). Beginning in 2007, several southeastern states in the US implemented restrictions on the commercial harvest of turtles, in order to address the unsustainable take. We have summarized freshwater turtle exports from the US between 2002 and 2012 and demonstrated that the magnitude of turtle exports from the US remained high although the exports decreased throughout the decade. Louisiana and California were the major exporters. The majority of exports were captive bred, and from two genera, Pseudemys and Trachemys. We review the changes over the decade and speculate that the increase in export of wild turtles out of Louisiana after 2007 could be a consequence of strict regulations in surrounding states (e.g., Alabama, Florida). We suggest that if wild turtle protection is a goal for conservation efforts, then these states should work together to develop comprehensive regulation reforms pertaining to the harvest of wild turtles. PMID:24475128

An RNA Interference Screen Identifies the Deubiquitinase STAMBPL1 as a Critical Regulator of Human T-Cell Leukemia Virus Type 1 Tax Nuclear Export and NF-κB Activation

PubMed Central

Lavorgna, Alfonso

2012-01-01

The human T-cell leukemia virus type 1 (HTLV-1) Tax oncoprotein actively shuttles between the nucleus, where it interacts with transcriptional and splicing regulatory proteins, and the cytoplasm, where it activates NF-κB. Posttranslational modifications of Tax such as ubiquitination regulate its subcellular localization and hence its function; however, the regulation of Tax trafficking and NF-κB activation by host factors is poorly understood. By screening a deubiquitinating (DUB) enzyme small interfering RNA (siRNA) library, we identified the metalloprotease STAM-binding protein-like 1 (STAMBPL1) as a positive regulator of Tax-mediated NF-κB activation. Overexpression of wild-type STAMBPL1, but not a catalytically inactive mutant, enhanced Tax-mediated NF-κB activation, whereas silencing of STAMBPL1 with siRNA impaired Tax activation of both the canonical and noncanonical NF-κB signaling pathways. STAMBPL1 regulated Tax-induced NF-κB signaling indirectly by controlling Tax nuclear/cytoplasmic transport and was required for DNA damage-induced Tax nuclear export. Together, these results reveal that the deubiquitinase STAMBPL1 is a key regulator of Tax trafficking and function. PMID:22258247

22 CFR 125.1 - Exports subject to this part.

Code of Federal Regulations, 2010 CFR

2010-04-01

... EXPORT OF TECHNICAL DATA AND CLASSIFIED DEFENSE ARTICLES § 125.1 Exports subject to this part. (a) The controls of this part apply to the export of technical data and the export of classified defense articles... to the controls of this subchapter. (b) A license for the export of technical data and the exemptions...

Nuclear localization signal regulates porcine circovirus type 2 capsid protein nuclear export through phosphorylation.

PubMed

Hou, Qiang; Hou, Shaohua; Chen, Qing; Jia, Hong; Xin, Ting; Jiang, Yitong; Guo, Xiaoyu; Zhu, Hongfei

2018-02-15

The open reading frame 2 (ORF2) of Porcine circovirus type 2 (PCV2) encodes the major Capsid (Cap) protein, which self-assembles into virus-like particle (VLP) of similar morphology to the PCV2 virion and accumulates in the nucleus through the N-terminal arginine-rich nuclear localization signal (NLS). In this study, PCV2 Cap protein and its derivates were expressed via the baculovirus expression system, and the cellular localization of the recombinant proteins were investigated using anti-Cap mAb by imaging flow cytometry. Analysis of subcellular localization of Cap protein and its variants demonstrated that NLS mediated Cap protein nuclear export as well as nuclear import, and a phosphorylation site (S17) was identified by liquid chromatography-tandem mass spectrometry (LC-MS/MS) in the NLS domain to regulate Cap protein nuclear export. Phosphorylation of NLS regulating the PCV2 Cap protein nuclear export was also demonstrated in PK15 cells by fluorescence microscopy. Moreover, the influence of Rep and Rep' protein on Cap protein subcellular localization was investigated in PK15 cells. Phosphorylation of NLS regulating Cap protein nuclear export provides more detailed knowledge of the PCV2 viral life cycle. Copyright © 2018 Elsevier B.V. All rights reserved.

77 FR 35661 - Federal Acquisition Regulation; Information Collection; Evaluation of Export Offers

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-14

...; Information Collection; Evaluation of Export Offers AGENCIES: Department of Defense (DOD), General Services..., 2012. ADDRESSES: Submit comments identified by Information Collection 9000- 0057, Evaluation of Export... via the Federal eRulemaking portal by inputting ``Information Collection 9000-0057, Evaluation of...

Bmp6 Expression in Murine Liver Non Parenchymal Cells: A Mechanism to Control their High Iron Exporter Activity and Protect Hepatocytes from Iron Overload?

PubMed Central

Rausa, Marco; Pagani, Alessia; Nai, Antonella; Campanella, Alessandro; Gilberti, Maria Enrica; Apostoli, Pietro; Camaschella, Clara; Silvestri, Laura

2015-01-01

Bmp6 is the main activator of hepcidin, the liver hormone that negatively regulates plasma iron influx by degrading the sole iron exporter ferroportin in enterocytes and macrophages. Bmp6 expression is modulated by iron but the molecular mechanisms are unknown. Although hepcidin is expressed almost exclusively by hepatocytes (HCs), Bmp6 is produced also by non-parenchymal cells (NPCs), mainly sinusoidal endothelial cells (LSECs). To investigate the regulation of Bmp6 in HCs and NPCs, liver cells were isolated from adult wild type mice whose diet was modified in iron content in acute or chronic manner and in disease models of iron deficiency (Tmprss6 KO mouse) and overload (Hjv KO mouse). With manipulation of dietary iron in wild-type mice, Bmp6 and Tfr1 expression in both HCs and NPCs was inversely related, as expected. When hepcidin expression is abnormal in murine models of iron overload (Hjv KO mice) and deficiency (Tmprss6 KO mice), Bmp6 expression in NPCs was not related to Tfr1. Despite the low Bmp6 in NPCs from Tmprss6 KO mice, Tfr1 mRNA was also low. Conversely, despite body iron overload and high expression of Bmp6 in NPCs from Hjv KO mice, Tfr1 mRNA and protein were increased. However, in the same cells ferritin L was only slightly increased, but the iron content was not, suggesting that Bmp6 in these cells reflects the high intracellular iron import and export. We propose that NPCs, sensing the iron flux, not only increase hepcidin through Bmp6 with a paracrine mechanism to control systemic iron homeostasis but, controlling hepcidin, they regulate their own ferroportin, inducing iron retention or release and further modulating Bmp6 production in an autocrine manner. This mechanism, that contributes to protect HC from iron loading or deficiency, is lost in disease models of hepcidin production. PMID:25860887

A calreticulin-dependent nuclear export signal is involved in the regulation of liver receptor homologue-1 protein folding.

PubMed

Yang, Feng-Ming; Feng, Shan-Jung; Lai, Tsai-Chun; Hu, Meng-Chun

2015-10-15

As an orphan member of the nuclear receptor family, liver receptor homologue-1 (LRH-1) controls a tremendous range of transcriptional programmes that are essential for metabolism and hormone synthesis. Our previous studies have shown that nuclear localization of the LRH-1 protein is mediated by two nuclear localization signals (NLSs) that are karyopherin/importin-dependent. It is unclear whether LRH-1 can be actively exported from the nucleus to the cytoplasm. In the present study, we describe a nuclear export domain containing two leucine-rich motifs [named nuclear export signal (NES)1 and NES2] within the ligand-binding domain (LBD). Mutation of leucine residues in NES1 or NES2 abolished nuclear export, indicating that both NES1 and NES2 motifs are essential for full nuclear export activity. This NES-mediated nuclear export was insensitive to the chromosomal region maintenance 1 (CRM1) inhibitor leptomycin B (LMB) or to CRM1 knockdown. However, knockdown of calreticulin (CRT) prevented NES-mediated nuclear export. Furthermore, our data show that CRT interacts with LRH-1 and is involved in the nuclear export of LRH-1. With full-length LRH-1, mutation of NES1 led to perinuclear accumulation of the mutant protein. Immunofluorescence analysis showed that these perinuclear aggregates were co-localized with the centrosome marker, microtubule-associated protein 1 light chain 3 (LC3), ubiquitin and heat shock protein 70 (Hsp70), indicating that the mutant was misfolded and sequestered into aggresome-like structures via the autophagic clearance pathway. Our study demonstrates for the first time that LRH-1 has a CRT-dependent NES which is not only required for cytoplasmic trafficking, but also essential for correct protein folding to avoid misfolding-induced aggregation. © 2015 Authors; published by Portland Press Limited.

76 FR 35275 - Export Control Reform Initiative: Strategic Trade Authorization License Exception

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-16

.... The Export Control Reform Initiative is designed to enhance U.S. national security and strengthen the... Security 15 CFR Parts 732, 738, 740, et al. Export Control Reform Initiative: Strategic Trade Authorization... Parts 732, 738, 740, 743, and 774 [Docket No. 100923470-1230-03] RIN 0694-AF03 Export Control Reform...

SR proteins are NXF1 adaptors that link alternative RNA processing to mRNA export.

PubMed

Müller-McNicoll, Michaela; Botti, Valentina; de Jesus Domingues, Antonio M; Brandl, Holger; Schwich, Oliver D; Steiner, Michaela C; Curk, Tomaz; Poser, Ina; Zarnack, Kathi; Neugebauer, Karla M

2016-03-01

Nuclear export factor 1 (NXF1) exports mRNA to the cytoplasm after recruitment to mRNA by specific adaptor proteins. How and why cells use numerous different export adaptors is poorly understood. Here we critically evaluate members of the SR protein family (SRSF1-7) for their potential to act as NXF1 adaptors that couple pre-mRNA processing to mRNA export. Consistent with this proposal, >1000 endogenous mRNAs required individual SR proteins for nuclear export in vivo. To address the mechanism, transcriptome-wide RNA-binding profiles of NXF1 and SRSF1-7 were determined in parallel by individual-nucleotide-resolution UV cross-linking and immunoprecipitation (iCLIP). Quantitative comparisons of RNA-binding sites showed that NXF1 and SR proteins bind mRNA targets at adjacent sites, indicative of cobinding. SRSF3 emerged as the most potent NXF1 adaptor, conferring sequence specificity to RNA binding by NXF1 in last exons. Interestingly, SRSF3 and SRSF7 were shown to bind different sites in last exons and regulate 3' untranslated region length in an opposing manner. Both SRSF3 and SRSF7 promoted NXF1 recruitment to mRNA. Thus, SRSF3 and SRSF7 couple alternative splicing and polyadenylation to NXF1-mediated mRNA export, thereby controlling the cytoplasmic abundance of transcripts with alternative 3' ends. © 2016 Müller-McNicoll et al.; Published by Cold Spring Harbor Laboratory Press.

A feedback regulatory model for RifQ-mediated repression of rifamycin export in Amycolatopsis mediterranei.

PubMed

Lei, Chao; Wang, Jingzhi; Liu, Yuanyuan; Liu, Xinqiang; Zhao, Guoping; Wang, Jin

2018-01-29

Due to the important role of rifamycin in curing tuberculosis infection, the study on rifamycin has never been stopped. Although RifZ, which locates within the rifamycin biosynthetic cluster, has recently been characterized as a pathway-specific regulator for rifamycin biosynthesis, little is known about the regulation of rifamycin export. In this work, we proved that the expression of the rifamycin efflux pump (RifP) was regulated by RifQ, a TetR-family transcriptional regulator. Deletion of rifQ had little impact on bacterial growth, but resulted in improved rifamycin production, which was consistent with the reverse transcription PCR results that RifQ negatively regulated rifP's transcription. With electrophoretic mobility shift assay and DNase I Footprinting assay, RifQ was found to directly bind to the promoter region of rifP, and a typical inverted repeat was identified within the RifQ-protected sequences. The transcription initiation site of rifP was further characterized and found to be upstream of the RifQ binding sites, well explaining the RifQ-mediated repression of rifP's transcription in vivo. Moreover, rifamycin B (the end product of rifamycin biosynthesis) remarkably decreased the DNA binding affinity of RifQ, which led to derepression of rifamycin export, reducing the intracellular concentration of rifamycin B as well as its toxicity against the host. Here, we proved that the export of rifamycin B was repressed by RifQ in Amycolatopsis mediterranei, and the RifQ-mediated repression could be specifically relieved by rifamycin B, the end product of rifamycin biosynthesis, based on which a feedback model was proposed for regulation of rifamycin export. With the findings here, one could improve the antibiotic yield by simply inactivating the negative regulator of the antibiotic transporter.

31 CFR 544.206 - Exempt transactions.

Code of Federal Regulations, 2014 CFR

2014-07-01

... informational materials, as defined in § 544.304, whether commercial or otherwise, regardless of format or... exempt or authorize transactions incident to the exportation of software subject to the Export Administration Regulations, 15 CFR parts 730-774, or to the exportation of goods, technology, or software for use...

31 CFR 544.206 - Exempt transactions.

Code of Federal Regulations, 2012 CFR

2012-07-01

... informational materials, as defined in § 544.304, whether commercial or otherwise, regardless of format or... exempt or authorize transactions incident to the exportation of software subject to the Export Administration Regulations, 15 CFR parts 730-774, or to the exportation of goods, technology, or software for use...

31 CFR 588.206 - Exempt transactions.

Code of Federal Regulations, 2010 CFR

2010-07-01

... defined in § 588.304, whether commercial or otherwise, regardless of format or medium of transmission, are... authorize transactions incident to the exportation of software subject to the Export Administration Regulations, 15 CFR parts 730-774, or to the exportation of goods, technology or software, or to the provision...

31 CFR 544.206 - Exempt transactions.

Code of Federal Regulations, 2010 CFR

2010-07-01

... informational materials, as defined in § 544.304, whether commercial or otherwise, regardless of format or... exempt or authorize transactions incident to the exportation of software subject to the Export Administration Regulations, 15 CFR parts 730-774, or to the exportation of goods, technology, or software for use...

31 CFR 544.206 - Exempt transactions.

Code of Federal Regulations, 2013 CFR

2013-07-01

... informational materials, as defined in § 544.304, whether commercial or otherwise, regardless of format or... exempt or authorize transactions incident to the exportation of software subject to the Export Administration Regulations, 15 CFR parts 730-774, or to the exportation of goods, technology, or software for use...

31 CFR 544.206 - Exempt transactions.

Code of Federal Regulations, 2011 CFR

2011-07-01

... informational materials, as defined in § 544.304, whether commercial or otherwise, regardless of format or... exempt or authorize transactions incident to the exportation of software subject to the Export Administration Regulations, 15 CFR parts 730-774, or to the exportation of goods, technology, or software for use...

7 CFR 800.17 - Special inspection and weighing requirements for sacked export grain.

Code of Federal Regulations, 2010 CFR

2010-01-01

... sacked export grain. 800.17 Section 800.17 Agriculture Regulations of the Department of Agriculture (Continued) GRAIN INSPECTION, PACKERS AND STOCKYARD ADMINISTRATION (FEDERAL GRAIN INSPECTION SERVICE... Requirements § 800.17 Special inspection and weighing requirements for sacked export grain. (a) General...

Regulatory aspects of pharmaceuticals' exports in gulf cooperation council countries.

PubMed

Pateriya, S; Janodia, Md; Deshpande, Pb; Ligade, Vs; Talole, Kb; Kulshrestha, T; Kamariya, Y; Musmade, Pb; Udupa, N

2011-04-01

The Gulf cooperation council (GCC) region is considered as "Emerging market" for pharmaceutical export and bilateral trade. The understanding of the regulatory requirements of this region can be beneficial for pharmaceutical export. Some incidents of the year 2008-09, like recession or economic slowdown in highly well-off and regulated market of the EU and US, raised the demand for alternate destinations for business. The regulations of Gulf countries are encouraging the import of quality generic products, which can be good news to the Indian drug manufacturers.

Regulatory Aspects of Pharmaceuticals’ Exports in Gulf Cooperation Council Countries

PubMed Central

Pateriya, S; Janodia, MD; Deshpande, PB; Ligade, VS; Talole, KB; Kulshrestha, T; Kamariya, Y; Musmade, PB; Udupa, N

2011-01-01

The Gulf cooperation council (GCC) region is considered as “Emerging market” for pharmaceutical export and bilateral trade. The understanding of the regulatory requirements of this region can be beneficial for pharmaceutical export. Some incidents of the year 2008-09, like recession or economic slowdown in highly well-off and regulated market of the EU and US, raised the demand for alternate destinations for business. The regulations of Gulf countries are encouraging the import of quality generic products, which can be good news to the Indian drug manufacturers. PMID:21731362

48 CFR 47.303-10 - F.o.b. inland carrier, point of exportation.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false F.o.b. inland carrier... ACQUISITION REGULATION CONTRACT MANAGEMENT TRANSPORTATION Transportation in Supply Contracts 47.303-10 F.o.b. inland carrier, point of exportation. (a) Explanation of delivery term. F.o.b. inland carrier, point of...

48 CFR 52.247-51 - Evaluation of Export Offers.

Code of Federal Regulations, 2012 CFR

2012-10-01

... Offers. 52.247-51 Section 52.247-51 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION....247-51 Evaluation of Export Offers. As prescribed in 47.305-6(e), insert the following provision... Government bill of lading. (1) Offers shall be evaluated and awards made on the basis of the lowest laid down...

48 CFR 52.247-51 - Evaluation of Export Offers.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Offers. 52.247-51 Section 52.247-51 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION....247-51 Evaluation of Export Offers. As prescribed in 47.305-6(e), insert the following provision... Government bill of lading. (1) Offers shall be evaluated and awards made on the basis of the lowest laid down...

48 CFR 52.247-51 - Evaluation of Export Offers.

Code of Federal Regulations, 2014 CFR

2014-10-01

... Offers. 52.247-51 Section 52.247-51 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION....247-51 Evaluation of Export Offers. As prescribed in 47.305-6(e), insert the following provision... Government bill of lading. (1) Offers shall be evaluated and awards made on the basis of the lowest laid down...

48 CFR 52.247-51 - Evaluation of Export Offers.

Code of Federal Regulations, 2013 CFR

2013-10-01

... Offers. 52.247-51 Section 52.247-51 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION....247-51 Evaluation of Export Offers. As prescribed in 47.305-6(e), insert the following provision... Government bill of lading. (1) Offers shall be evaluated and awards made on the basis of the lowest laid down...

The ubiquitin ligase MuRF1 regulates PPARα activity in the heart by enhancing nuclear export via monoubiquitination

PubMed Central

Rodríguez, Jessica E.; Liao, Jie-Ying; He, Jun; Schisler, Jonathan C.; Newgard, Christopher B.; Drujan, Doreen; Glass, David L.; Frederick, C.Brandon; Yoder, Bryan C.; Lalush, David S.; Patterson, Cam; Willis, Monte S.

2015-01-01

The transcriptional regulation of peroxisome proliferator-activated receptor (PPAR) α by post-translational modification, such as ubiquitin, has not been described. We report here for the first time an ubiquitin ligase (muscle ring finger-1/MuRF1) that inhibits fatty acid oxidation by inhibiting PPARα, but not PPARβ/δ or PPARγ in cardiomyocytes in vitro. Similarly, MuRF1 Tg+ hearts showed significant decreases in nuclear PPARα activity and acyl-carnitine intermediates, while MuRF1−/− hearts exhibited increased PPARα activity and acyl-carnitine intermediates. MuRF1 directly interacts with PPARα, mono-ubiquitinates it, and targets it for nuclear export to inhibit fatty acid oxidation in a proteasome independent manner. We then identified a previously undescribed nuclear export sequence in PPARα, along with three specific lysines (292, 310, 388) required for MuRF1s targeting of nuclear export. These studies identify the role of ubiquitination in regulating cardiac PPARα, including the ubiquitin ligase that may be responsible for this critical regulation of cardiac metabolism in heart failure. PMID:26116825

Implementation of the Ryan Haight Online Pharmacy Consumer Protection Act of 2008. Interim final rule with request for comments.

PubMed

2009-04-06

The Ryan Haight Online Pharmacy Consumer Protection Act, which was enacted on October 15, 2008, amended the Controlled Substances Act and Controlled Substances Import and Export Act by adding several new provisions to prevent the illegal distribution and dispensing of controlled substances by means of the Internet. DEA is hereby issuing an interim rule to amend its regulations to implement the legislation and is requesting comments on the interim rule.

7 CFR 35.8 - Date of export.

Code of Federal Regulations, 2011 CFR

2011-01-01

... Practices), DEPARTMENT OF AGRICULTURE COMMODITY STANDARDS AND STANDARD CONTAINER REGULATIONS EXPORT GRAPES... exporting carrier on which movement of the grapes from the United States is effected. The date of the on board bill of lading (or loading tally sheet) shall be considered to be the date the grapes were loaded...

50 CFR 23.56 - What U.S. CITES document conditions do I need to follow?

Code of Federal Regulations, 2012 CFR

2012-10-01

... International Air Transport Association Live Animals Regulations. (3) You must return the original CITES..., EXPORTATION, AND IMPORTATION OF WILDLIFE AND PLANTS (CONTINUED) CONVENTION ON INTERNATIONAL TRADE IN..., Federal, tribal, and foreign wildlife or plant conservation laws. (2) For export and re-export of live...

50 CFR 23.56 - What U.S. CITES document conditions do I need to follow?

Code of Federal Regulations, 2013 CFR

2013-10-01

... International Air Transport Association Live Animals Regulations. (3) You must return the original CITES..., EXPORTATION, AND IMPORTATION OF WILDLIFE AND PLANTS (CONTINUED) CONVENTION ON INTERNATIONAL TRADE IN..., Federal, tribal, and foreign wildlife or plant conservation laws. (2) For export and re-export of live...

5 CFR 6201.101 - General.

Code of Federal Regulations, 2010 CFR

2010-01-01

... Administrative Personnel EXPORT-IMPORT BANK OF THE UNITED STATES SUPPLEMENTAL STANDARDS OF ETHICAL CONDUCT FOR EMPLOYEES OF THE EXPORT-IMPORT BANK OF THE UNITED STATES § 6201.101 General. In accordance with 5 CFR 2635.105, the regulations in this part apply to employees of the Export-Import Bank of the United States...

45 CFR 670.32 - Specific issuance criteria for exports.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 45 Public Welfare 3 2014-10-01 2014-10-01 false Specific issuance criteria for exports. 670.32 Section 670.32 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL SCIENCE FOUNDATION CONSERVATION OF ANTARCTIC ANIMALS AND PLANTS Import Into and Export From the United States § 670...

45 CFR 670.32 - Specific issuance criteria for exports.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 45 Public Welfare 3 2012-10-01 2012-10-01 false Specific issuance criteria for exports. 670.32 Section 670.32 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL SCIENCE FOUNDATION CONSERVATION OF ANTARCTIC ANIMALS AND PLANTS Import Into and Export From the United States § 670...

45 CFR 670.32 - Specific issuance criteria for exports.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 45 Public Welfare 3 2013-10-01 2013-10-01 false Specific issuance criteria for exports. 670.32 Section 670.32 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL SCIENCE FOUNDATION CONSERVATION OF ANTARCTIC ANIMALS AND PLANTS Import Into and Export From the United States § 670...

45 CFR 670.32 - Specific issuance criteria for exports.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 45 Public Welfare 3 2011-10-01 2011-10-01 false Specific issuance criteria for exports. 670.32 Section 670.32 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL SCIENCE FOUNDATION CONSERVATION OF ANTARCTIC ANIMALS AND PLANTS Import Into and Export From the United States § 670...

15 CFR 30.6 - Electronic Export Information data elements.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 15 Commerce and Foreign Trade 1 2012-01-01 2012-01-01 false Electronic Export Information data elements. 30.6 Section 30.6 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade... Electronic Export Information data elements. The information specified in this section is required for...

15 CFR 30.6 - Electronic Export Information data elements.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 15 Commerce and Foreign Trade 1 2013-01-01 2013-01-01 false Electronic Export Information data elements. 30.6 Section 30.6 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade... Electronic Export Information data elements. The information specified in this section is required for...

7 CFR 20.9 - Records.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 7 Agriculture 1 2014-01-01 2014-01-01 false Records. 20.9 Section 20.9 Agriculture Office of the Secretary of Agriculture EXPORT SALES REPORTING REQUIREMENTS § 20.9 Records. Each reporting exporter shall establish and maintain accurate records as to all export sales of commodities subject to these regulations...

7 CFR 20.9 - Records.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 1 2010-01-01 2010-01-01 false Records. 20.9 Section 20.9 Agriculture Office of the Secretary of Agriculture EXPORT SALES REPORTING REQUIREMENTS § 20.9 Records. Each reporting exporter shall establish and maintain accurate records as to all export sales of commodities subject to these regulations...

31 CFR 576.209 - Exempt transactions.

Code of Federal Regulations, 2012 CFR

2012-07-01

..., as defined in § 576.306, whether commercial or otherwise, regardless of format or medium of... does not exempt or authorize transactions incident to the exportation of software subject to the Export Administration Regulations, 15 CFR parts 730-774, or to the exportation of goods, technology, or software for use...

31 CFR 576.209 - Exempt transactions.

Code of Federal Regulations, 2011 CFR

2011-07-01

..., as defined in § 576.306, whether commercial or otherwise, regardless of format or medium of... does not exempt or authorize transactions incident to the exportation of software subject to the Export Administration Regulations, 15 CFR parts 730-774, or to the exportation of goods, technology, or software for use...

31 CFR 576.209 - Exempt transactions.

Code of Federal Regulations, 2013 CFR

2013-07-01

..., as defined in § 576.306, whether commercial or otherwise, regardless of format or medium of... does not exempt or authorize transactions incident to the exportation of software subject to the Export Administration Regulations, 15 CFR parts 730-774, or to the exportation of goods, technology, or software for use...

15 CFR 30.2 - General requirements for filing Electronic Export Information (EEI).

Code of Federal Regulations, 2014 CFR

2014-01-01

... definitions, specifications, and requirements of the regulations in this part for all export shipments, except... 15 Commerce and Foreign Trade 1 2014-01-01 2014-01-01 false General requirements for filing... Requirements § 30.2 General requirements for filing Electronic Export Information (EEI). (a) Filing...

22 CFR 120.32 - Major non-NATO ally.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 22 Foreign Relations 1 2012-04-01 2012-04-01 false Major non-NATO ally. 120.32 Section 120.32 Foreign Relations DEPARTMENT OF STATE INTERNATIONAL TRAFFIC IN ARMS REGULATIONS PURPOSE AND DEFINITIONS... the Foreign Assistance Act of 1961 and the Arms Export Control Act (22 U.S.C. 2751 et seq.) (22 U.S.C...

22 CFR 120.32 - Major non-NATO ally.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Major non-NATO ally. 120.32 Section 120.32 Foreign Relations DEPARTMENT OF STATE INTERNATIONAL TRAFFIC IN ARMS REGULATIONS PURPOSE AND DEFINITIONS... the Foreign Assistance Act of 1961 and the Arms Export Control Act (22 U.S.C. 2751 et seq.) (22 U.S.C...

22 CFR 120.32 - Major non-NATO ally.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 22 Foreign Relations 1 2011-04-01 2011-04-01 false Major non-NATO ally. 120.32 Section 120.32 Foreign Relations DEPARTMENT OF STATE INTERNATIONAL TRAFFIC IN ARMS REGULATIONS PURPOSE AND DEFINITIONS... the Foreign Assistance Act of 1961 and the Arms Export Control Act (22 U.S.C. 2751 et seq.) (22 U.S.C...

22 CFR 120.32 - Major non-NATO ally.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 22 Foreign Relations 1 2013-04-01 2013-04-01 false Major non-NATO ally. 120.32 Section 120.32 Foreign Relations DEPARTMENT OF STATE INTERNATIONAL TRAFFIC IN ARMS REGULATIONS PURPOSE AND DEFINITIONS... the Foreign Assistance Act of 1961 and the Arms Export Control Act (22 U.S.C. 2151 et seq. and 22 U.S...

22 CFR 120.32 - Major non-NATO ally.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 22 Foreign Relations 1 2014-04-01 2014-04-01 false Major non-NATO ally. 120.32 Section 120.32 Foreign Relations DEPARTMENT OF STATE INTERNATIONAL TRAFFIC IN ARMS REGULATIONS PURPOSE AND DEFINITIONS... the Foreign Assistance Act of 1961 and the Arms Export Control Act (22 U.S.C. 2151 et seq. and 22 U.S...

78 FR 42430 - Revisions to the Export Administration Regulations Based on the 2012 Missile Technology Control...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-16

.... This specific decontrol helps to clarify what is usable for rockets, missiles, or unmanned aerial... specified by 4.C. in the Annex or used in Category I rocket systems. These commodities and the related... propulsion data into a flight management system, designed or modified for rockets or missiles capable of...

15 CFR Supplement No. 2 to Part 774 - General Technology and Software Notes

Code of Federal Regulations, 2010 CFR

2010-01-01

... 15 Commerce and Foreign Trade 2 2010-01-01 2010-01-01 false General Technology and Software Notes... REGULATIONS THE COMMERCE CONTROL LIST Pt. 774, Supp. 2 Supplement No. 2 to Part 774—General Technology and Software Notes 1. General Technology Note. The export of “technology” that is “required” for the...

15 CFR 713.3 - Annual declaration and reporting requirements for exports and imports of Schedule 2 chemicals.

Code of Federal Regulations, 2010 CFR

2010-01-01

... requirements for exports and imports of Schedule 2 chemicals. 713.3 Section 713.3 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE CHEMICAL WEAPONS CONVENTION REGULATIONS ACTIVITIES INVOLVING SCHEDULE 2 CHEMICALS § 713.3 Annual...

7 CFR 35.7 - Certificate.

Code of Federal Regulations, 2011 CFR

2011-01-01

... Practices), DEPARTMENT OF AGRICULTURE COMMODITY STANDARDS AND STANDARD CONTAINER REGULATIONS EXPORT GRAPES... official forms of inspection certificate, bearing the statement “meets Export Grape and Plum Act,” issued...

22 CFR 125.1 - Exports subject to this part.

Code of Federal Regulations, 2011 CFR

2011-04-01

... EXPORT OF TECHNICAL DATA AND CLASSIFIED DEFENSE ARTICLES § 125.1 Exports subject to this part. (a) The controls of this part apply to the export of technical data and the export of classified defense articles... defense articles if the technical data is determined by the Directorate of Defense Trade Controls to be...

15 CFR 30.17 - Customs and Border Protection regulations.

Code of Federal Regulations, 2012 CFR

2012-01-01

..., for information referencing the advanced electronic submission of cargo information on exports for... postdeparture filing of export information for certain shipments, and contain other regulatory provisions...

48 CFR 552.211-89 - Non-manufactured wood packaging material for export.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 48 Federal Acquisition Regulations System 4 2012-10-01 2012-10-01 false Non-manufactured wood... and Clauses 552.211-89 Non-manufactured wood packaging material for export. As prescribed in 511.204(b)(4), insert the following clause: Non-Manufactured Wood Packaging Material for Export (JAN 2010) (a...

48 CFR 552.211-89 - Non-manufactured wood packaging material for export.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 48 Federal Acquisition Regulations System 4 2014-10-01 2014-10-01 false Non-manufactured wood... and Clauses 552.211-89 Non-manufactured wood packaging material for export. As prescribed in 511.204(b)(4), insert the following clause: Non-Manufactured Wood Packaging Material for Export (JAN 2010) (a...

48 CFR 552.211-89 - Non-manufactured wood packaging material for export.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 48 Federal Acquisition Regulations System 4 2013-10-01 2013-10-01 false Non-manufactured wood... and Clauses 552.211-89 Non-manufactured wood packaging material for export. As prescribed in 511.204(b)(4), insert the following clause: Non-Manufactured Wood Packaging Material for Export (JAN 2010) (a...

77 FR 39392 - Amendment to the International Traffic in Arms Regulations: Yemen

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-03

... toward Yemen. Licenses or other approvals for exports or imports of defense articles and defense services..., providing that the defense export policy for Yemen included a ``presumption of denial'' for proposed exports... defense services and non-lethal, safety-of-use defense articles for lethal end-items. License applications...

The Role of Further Government Intervention in Australian International Education

ERIC Educational Resources Information Center

Carrington, Roger; Meek, V. Lynn; Wood, Fiona Q.

2007-01-01

Trade in Australian education services has expanded rapidly over recent years. The sector is the third largest exporter of Australian services. In 2001-2002, exports of education were about $A 4.2 billion. Government assistance to the sector includes export market development, regulation of education standards, and funding education activities;…

15 CFR 740.15 - Aircraft and vessels (AVS).

Code of Federal Regulations, 2014 CFR

2014-01-01

... Automated Export System (AES) record is filed in accordance with the requirements of the Foreign Trade Statistics Regulations (15 CFR part 30), except that an SED or AES record is not required when any of the...'s Export Declaration (SED) or Automated Export System (AES) record is filed in accordance with the...

15 CFR 740.15 - Aircraft and vessels (AVS).

Code of Federal Regulations, 2012 CFR

2012-01-01

... Automated Export System (AES) record is filed in accordance with the requirements of the Foreign Trade Statistics Regulations (15 CFR part 30), except that an SED or AES record is not required when any of the...'s Export Declaration (SED) or Automated Export System (AES) record is filed in accordance with the...

15 CFR 740.15 - Aircraft and vessels (AVS).

Code of Federal Regulations, 2013 CFR

2013-01-01

... Automated Export System (AES) record is filed in accordance with the requirements of the Foreign Trade Statistics Regulations (15 CFR part 30), except that an SED or AES record is not required when any of the...'s Export Declaration (SED) or Automated Export System (AES) record is filed in accordance with the...

78 FR 16365 - Foreign Trade Regulations: Mandatory Automated Export System Filing for All Shipments Requiring...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-14

... collecting, compiling, and publishing export trade statistics for the United States under the provisions of... for collecting export trade data, which is used by the Census Bureau for statistical purposes only... timely statistics as well as address the enforcement and security concerns of CBP, the Bureau of Industry...

37 CFR 5.20 - Export of technical data relating to sensitive nuclear technology.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 37 Patents, Trademarks, and Copyrights 1 2012-07-01 2012-07-01 false Export of technical data relating to sensitive nuclear technology. 5.20 Section 5.20 Patents, Trademarks, and Copyrights UNITED....20 Export of technical data relating to sensitive nuclear technology. Under regulations (10 CFR 810.7...

37 CFR 5.20 - Export of technical data relating to sensitive nuclear technology.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 37 Patents, Trademarks, and Copyrights 1 2014-07-01 2014-07-01 false Export of technical data relating to sensitive nuclear technology. 5.20 Section 5.20 Patents, Trademarks, and Copyrights UNITED....20 Export of technical data relating to sensitive nuclear technology. Under regulations (10 CFR 810.7...

37 CFR 5.20 - Export of technical data relating to sensitive nuclear technology.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 37 Patents, Trademarks, and Copyrights 1 2013-07-01 2013-07-01 false Export of technical data relating to sensitive nuclear technology. 5.20 Section 5.20 Patents, Trademarks, and Copyrights UNITED....20 Export of technical data relating to sensitive nuclear technology. Under regulations (10 CFR 810.7...

15 CFR 720.1 - Denial of export privileges for convictions under 18 U.S.C. 229.

Code of Federal Regulations, 2011 CFR

2011-01-01

... threatening to use, a chemical weapon; or (b) Assisting or inducing, in any way, any person to violate... Commerce and Foreign Trade (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE CHEMICAL WEAPONS CONVENTION REGULATIONS DENIAL OF EXPORT PRIVILEGES § 720.1 Denial of export privileges for...

15 CFR 720.1 - Denial of export privileges for convictions under 18 U.S.C. 229.

Code of Federal Regulations, 2010 CFR

2010-01-01

... threatening to use, a chemical weapon; or (b) Assisting or inducing, in any way, any person to violate... Commerce and Foreign Trade (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE CHEMICAL WEAPONS CONVENTION REGULATIONS DENIAL OF EXPORT PRIVILEGES § 720.1 Denial of export privileges for...

48 CFR 552.211-89 - Non-manufactured wood packaging material for export.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 48 Federal Acquisition Regulations System 4 2011-10-01 2011-10-01 false Non-manufactured wood... and Clauses 552.211-89 Non-manufactured wood packaging material for export. As prescribed in 511.204(b)(4), insert the following clause: Non-Manufactured Wood Packaging Material for Export (JAN 2010) (a...

48 CFR 552.211-89 - Non-manufactured wood packaging material for export.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Non-manufactured wood... and Clauses 552.211-89 Non-manufactured wood packaging material for export. As prescribed in 511.204(b)(4), insert the following clause: Non-Manufactured Wood Packaging Material for Export (JAN 2010) (a...

15 CFR 1300.1 - Reporting of exports of technology to nonmarket economy countries.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 15 Commerce and Foreign Trade 3 2014-01-01 2014-01-01 false Reporting of exports of technology to nonmarket economy countries. 1300.1 Section 1300.1 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) EAST-WEST FOREIGN TRADE BOARD REPORTS ON EXPORTS OF TECHNOLOGY...

Bayesian Networks to Compare Pest Control Interventions on Commodities Along Agricultural Production Chains.

PubMed

Holt, J; Leach, A W; Johnson, S; Tu, D M; Nhu, D T; Anh, N T; Quinlan, M M; Whittle, P J L; Mengersen, K; Mumford, J D

2018-02-01

The production of an agricultural commodity involves a sequence of processes: planting/growing, harvesting, sorting/grading, postharvest treatment, packing, and exporting. A Bayesian network has been developed to represent the level of potential infestation of an agricultural commodity by a specified pest along an agricultural production chain. It reflects the dependency of this infestation on the predicted level of pest challenge, the anticipated susceptibility of the commodity to the pest, the level of impact from pest control measures as designed, and any variation from that due to uncertainty in measure efficacy. The objective of this Bayesian network is to facilitate agreement between national governments of the exporters and importers on a set of phytosanitary measures to meet specific phytosanitary measure requirements to achieve target levels of protection against regulated pests. The model can be used to compare the performance of different combinations of measures under different scenarios of pest challenge, making use of available measure performance data. A case study is presented using a model developed for a fruit fly pest on dragon fruit in Vietnam; the model parameters and results are illustrative and do not imply a particular level of fruit fly infestation of these exports; rather, they provide the most likely, alternative, or worst-case scenarios of the impact of measures. As a means to facilitate agreement for trade, the model provides a framework to support communication between exporters and importers about any differences in perceptions of the risk reduction achieved by pest control measures deployed during the commodity production chain. © 2017 Society for Risk Analysis.

19 CFR 192.0 - Scope.

Code of Federal Regulations, 2012 CFR

2012-04-01

... exportation of used self-propelled vehicles, vessels and aircraft, and the penalties and liabilities incurred... provision for the Automated Export System (AES), implemented by the Census Regulations at part 30, subpart E...

19 CFR 192.0 - Scope.

Code of Federal Regulations, 2013 CFR

2013-04-01

... exportation of used self-propelled vehicles, vessels and aircraft, and the penalties and liabilities incurred... provision for the Automated Export System (AES), implemented by the Census Regulations at part 30, subpart E...

19 CFR 192.0 - Scope.

Code of Federal Regulations, 2014 CFR

2014-04-01

... exportation of used self-propelled vehicles, vessels and aircraft, and the penalties and liabilities incurred... provision for the Automated Export System (AES), implemented by the Census Regulations at part 30, subpart E...

19 CFR 192.0 - Scope.

Code of Federal Regulations, 2011 CFR

2011-04-01

... exportation of used self-propelled vehicles, vessels and aircraft, and the penalties and liabilities incurred... provision for the Automated Export System (AES), implemented by the Census Regulations at part 30, subpart E...

19 CFR 192.0 - Scope.

Code of Federal Regulations, 2010 CFR

2010-04-01

... exportation of used self-propelled vehicles, vessels and aircraft, and the penalties and liabilities incurred... provision for the Automated Export System (AES), implemented by the Census Regulations at part 30, subpart E...

78 FR 37788 - In the Matter of: Juan Ricardo Puente-Paez, Inmate Number #05086-379, FCI McDowell, Federal...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-24

... exported from the United States to Mexico four military spec Interceptor body armor vests, which were... owned, possessed or controlled by the Denied Person, or service any item, of whatever origin, that is... subject to the Regulations are the foreign-produced direct product of U.S.-origin technology. V. This...

Can the HIV-1 splicing machinery be targeted for drug discovery?

PubMed Central

Dlamini, Zodwa; Hull, Rodney

2017-01-01

HIV-1 is able to express multiple protein types and isoforms from a single 9 kb mRNA transcript. These proteins are also expressed at particular stages of viral development, and this is achieved through the control of alternative splicing and the export of these transcripts from the nucleus. The nuclear export is controlled by the HIV protein Rev being required to transport incompletely spliced and partially spliced mRNA from the nucleus where they are normally retained. This implies a close relationship between the control of alternate splicing and the nuclear export of mRNA in the control of HIV-1 viral proliferation. This review discusses both the processes. The specificity and regulation of splicing in HIV-1 is controlled by the use of specific splice sites as well as exonic splicing enhancer and exonic splicing silencer sequences. The use of these silencer and enhancer sequences is dependent on the serine arginine family of proteins as well as the heterogeneous nuclear ribonucleoprotein family of proteins that bind to these sequences and increase or decrease splicing. Since alternative splicing is such a critical factor in viral development, it presents itself as a promising drug target. This review aims to discuss the inhibition of splicing, which would stall viral development, as an anti-HIV therapeutic strategy. In this review, the most recent knowledge of splicing in human immunodeficiency viral development and the latest therapeutic strategies targeting human immunodeficiency viral splicing are discussed. PMID:28331370

The function of the inner nuclear envelope protein SUN1 in mRNA export is regulated by phosphorylation.

PubMed

Li, Ping; Stumpf, Maria; Müller, Rolf; Eichinger, Ludwig; Glöckner, Gernot; Noegel, Angelika A

2017-08-22

SUN1, a component of the LINC (Linker of Nucleoskeleton and Cytoskeleton) complex, functions in mammalian mRNA export through the NXF1-dependent pathway. It associates with mRNP complexes by direct interaction with NXF1. It also binds to the NPC through association with the nuclear pore component Nup153, which is involved in mRNA export. The SUN1-NXF1 association is at least partly regulated by a protein kinase C (PKC) which phosphorylates serine 113 (S113) in the N-terminal domain leading to reduced interaction. The phosphorylation appears to be important for the SUN1 function in nuclear mRNA export since GFP-SUN1 carrying a S113A mutation was less efficient in restoring mRNA export after SUN1 knockdown as compared to the wild type protein. By contrast, GFP-SUN1-S113D resembling the phosphorylated state allowed very efficient export of poly(A)+RNA. Furthermore, probing a possible role of the LINC complex component Nesprin-2 in this process we observed impaired mRNA export in Nesprin-2 knockdown cells. This effect might be independent of SUN1 as expression of a GFP tagged SUN-domain deficient SUN1, which no longer can interact with Nesprin-2, did not affect mRNA export.

77 FR 75011 - Revisions to Authorization Validated End-User Provisions: Requirement for Notice of Export...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-19

... Bureau of Industry and Security (BIS) amends the Export Administration Regulations (EAR) by adding a...-specific conditions under Authorization VEU no longer require a license for export or reexport or become eligible for shipment under a license exception, as set forth in the EAR, VEUs are no longer bound by the...

75 FR 16732 - Action Affecting Export Privileges; Aqua-Loop Cooling Towers, Co.

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-02

... Regulations by facilitating or coordinating the export of approximately 174 rolls of hog hair filter media... about September 28, 2004, Aqua-Loop ordered or financed approximately 174 rolls of hog hair filter media... coordinating the export of approximately 185 rolls of hog hair filter media, part number HHB6O 130 and valued...

76 FR 22865 - Action Affecting Export Privileges; Orion Air, S.L. and Syrian Pearl Airlines

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-25

... to the EAR that has been or will be exported from the United States. For purposes of this paragraph....24 of the Export Administration Regulations, 15 CFR parts 730-774 (2011) (``EAR'' or the... violation of the EAR. I. Procedural History On May 7, 2009, then-Acting Assistant Secretary of Commerce for...