Sample records for exporting case studies

  1. An analysis of the relationship between staff qualification and export readiness of pharmaceutical companies: the case of iran.

    PubMed

    Mohammadzadeh, Mehdi

    2012-01-01

    Export and the readiness to export constitute the first step of international marketing, which are affected by both internal and external factors of firms. One of the most important internal factors is the presence of skilled personnel. The purpose of this study was to define the relationship between staff qualification and encouragment with the readiness level of Iranian pharmacuetical firms for engagement in export marketing. The research was based on a single case study on a basket of seven leading domestic firms. For the bias reduction, questionnaires as well as interviews with managers were used. The performance of the studied factor was lower than the desired level for export readiness and there was much scope for improvement in staff qualifications to achieve such readiness. The results of this research enable small and medium-sized pharmaceutical companies to evaluate their staff qualification levels needed for export readiness and to detect their shortcomings in order to improve them.

  2. An Analysis of the Relationship Between Staff Qualification and Export Readiness of Pharmaceutical Companies: The Case of Iran

    PubMed Central

    Mohammadzadeh, Mehdi

    2012-01-01

    Export and the readiness to export constitute the first step of international marketing, which are affected by both internal and external factors of firms. One of the most important internal factors is the presence of skilled personnel. The purpose of this study was to define the relationship between staff qualification and encouragment with the readiness level of Iranian pharmacuetical firms for engagement in export marketing. The research was based on a single case study on a basket of seven leading domestic firms. For the bias reduction, questionnaires as well as interviews with managers were used. The performance of the studied factor was lower than the desired level for export readiness and there was much scope for improvement in staff qualifications to achieve such readiness. The results of this research enable small and medium-sized pharmaceutical companies to evaluate their staff qualification levels needed for export readiness and to detect their shortcomings in order to improve them. PMID:24250528

  3. Insights into public export promotion programs in an emerging economy: the case of Malaysian SMEs.

    PubMed

    Ayob, Abu H; Freixanet, Joan

    2014-10-01

    This study evaluates the impact of public export promotion programs (EPPs) among small and medium-sized enterprises (SMEs) in Malaysia. Three indicators, level of awareness, frequency of use, and perception of usefulness, were examined according to a firm's export status. The global evaluation suggests that exporters are more frequent users of EPPs and perceive them to be more useful than non-exporters. Nonetheless, both groups demonstrate higher levels of awareness, are frequent users, and perceive the programs relating to export info/knowledge are more usefulness than programs relating to financial assistance. Further analysis also reveals that the frequency of use and the perception of usefulness for most programs are positively related to export experience, but not to export turnover. This study offers insights into the effectiveness of export programs for encouraging export initiation and expansion in an emerging economy. Copyright © 2014 Elsevier Ltd. All rights reserved.

  4. Inspection of the Department`s export licensing process for dual-use and munitions commodities

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Not Available

    1993-08-10

    The purpose of our inspection was to review the Department of Energy`s (Energy) export licensing process for dual-use and military (munitions) commodities subject to nuclear nonproliferation controls. Specifically, we reviewed Energy`s authorities, procedures, and policies pertaining to the export licensing process and examined procedures for safeguarding data transmitted between Energy and other agencies involved in the export licensing process. We also reviewed Energy`s role as a member of the Subgroup on Nuclear Export Coordination. Our review of the sample of 60 export cases did not find evidence to lead us to believe that Energy`s recommendations for these cases were inappropriatemore » or incorrect. We identified, however, problems regarding management systems associated with the export license review process. We found that without documentation supporting export licensing decisions by the Export Control Operations Division (ECOD), we could not determine whether ECOD analysts considered all required criteria in their review of export cases referred to Energy. For example, we found that the ECOD did not retain records documenting the bases for its advice, recommendations, or decisions regarding its reviews of export license cases or revisions to lists of controlled commodities and, therefore, was not in compliance with certain provisions of the Export Administration Act, as amended, and Energy records management directives. Additionally, we found that the degree of compliance by Energy with the export licensing review criteria contained in the Export Administration Regulations and the Nuclear Non-Proliferation Act of 1978 could not be determined because ECOD did not retain records documenting the bases for its advice and recommendations on export cases.« less

  5. Quantifying the potential export flows of used electronic products in Macau: a case study of PCs.

    PubMed

    Yu, Danfeng; Song, Qingbin; Wang, Zhishi; Li, Jinhui; Duan, Huabo; Wang, Jinben; Wang, Chao; Wang, Xu

    2017-12-01

    The used electronic product (UEP) has attracted the worldwide attentions because part of e-waste may be exported from developed countries to developing countries in the name of UEP. On the basis of large foreign trade data of electronic products (e-products), this study adopted the trade data approach (TDA) to quantify the potential exports of UEP in Macau, taking a case study of personal computers (PCs). The results show that the desktop mainframes, LCD monitors, and CRT monitors have more low-unit-value trades with higher trade volumes in the past 10 years, while the laptop and tablet PCs, as the newer technologies, owned the higher ratios of the high-unit-value trades. During the period of 2005-2015, the total mean exports for used laptop and tablet PCs, desktop mainframes, and LCD monitors were approximately 18,592, 79,957, and 43,177 units, respectively, while the possible export volume of used CRT monitors was higher, up to 430,098 units in 2000-2010. Noticed that these potential export volumes could be the lower bound because not all used PCs may be shipped using the PC trade code. For all the four kinds of used PCs, the majority (61.6-98.82%) of the export volumes have gone to Hong Kong, followed by Mainland China and Taiwan. Since 2011, there was no CRT monitor export; however, the other kinds of used PC exports will still exist in Macau in the future. The outcomes are helpful to understand and manage the current export situations of used products in Macau, and can also provide a reference for other countries and regions.

  6. Export of health services from developing countries: the case of Tunisia.

    PubMed

    Lautier, Marc

    2008-07-01

    Although the subject of health services exports by developing countries has been much discussed, the phenomenon is still in its early stage, and its real implications are not yet clear. Given the rapid development in this area, little empirical data are available. This paper aims to fill this gap by providing reliable data on consumption of health services abroad (GATS mode 2 of international service supply). It starts by assessing the magnitude of the volume of international trade in health services. This is followed by an in-depth analysis of the case of Tunisia based on an original field research. Because of the high quality of its health sector and its proximity with Europe, Tunisia has the highest export potential for health services in the Middle-East and North Africa (MENA) Region. Health services exports may represent a quarter of Tunisia's private health sector output and generate jobs for 5000 employees. If one takes into account tourism expenses by the incoming patient (and their relatives), these exports contribute to nearly 1% of the country's total exports. Finally, this case study highlights the regional dimension of external demand for health services and the predominance of South-South trade.

  7. Fishing inside or outside? A case studies analysis of potential spillover effect from marine protected areas, using food web models

    NASA Astrophysics Data System (ADS)

    Colléter, Mathieu; Gascuel, Didier; Albouy, Camille; Francour, Patrice; Tito de Morais, Luis; Valls, Audrey; Le Loc'h, François

    2014-11-01

    Marine protected areas (MPAs) are implemented worldwide as an efficient tool to preserve biodiversity and protect ecosystems. We used food web models (Ecopath and EcoTroph) to assess the ability of MPAs to reduce fishing impacts on targeted resources and to provide biomass exports for adjacent fisheries. Three coastal MPAs: Bonifacio and Port-Cros (Mediterranean Sea), and Bamboung (Senegalese coast), were used as case studies. Pre-existing related Ecopath models were homogenized and ecosystem characteristics were compared based on network indices and trophic spectra analyses. Using the EcoTroph model, we simulated different fishing mortality scenarios and assessed fishing impacts on the three ecosystems. Lastly, the potential biomass that could be exported from each MPA was estimated. Despite structural and functional trophic differences, the three MPAs showed similar patterns of resistance to simulated fishing mortalities, with the Bonifacio case study exhibiting the highest potential catches and a slightly inferior resistance to fishing. We also show that the potential exports from our small size MPAs are limited and thus may only benefit local fishing activities. Based on simulations, their potential exports were estimated to be at the same order of magnitude as the amount of catch that could have been obtained inside the reserve. In Port Cros, the ban of fishing inside MPA could actually allow for improved catch yields outside the MPA due to biomass exports. This was not the case for the Bonifacio site, as its potential exports were too low to offset catch losses. This insight suggests the need for MPA networks and/or sufficiently large MPAs to effectively protect juveniles and adults and provide important exports. Finally, we discuss the effects of MPAs on fisheries that were not considered in food web models, and conclude by suggesting possible improvements in the analysis of MPA efficiency.

  8. 27 CFR 28.223 - Export marks.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Export marks. 28.223... Export marks. In addition to the marks and brands required to be placed on kegs, barrels, cases, crates... “Export” on each container or case before removal for export, for use on vessels or aircraft, or for...

  9. 22 CFR 120.30 - The Automated Export System (AES).

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... DEFINITIONS § 120.30 The Automated Export System (AES). The Automated Export System (AES) is the Department of Commerce, Bureau of Census, electronic filing of export information. The AES shall serve as the primary...). Also, requests for special reporting may be made by DDTC on a case-by-case basis, (e.g., compliance...

  10. Adjusting export tax rebates to reduce the environmental impacts of trade: Lessons from China.

    PubMed

    Song, Peng; Mao, Xianqiang; Corsetti, Gabriel

    2015-09-15

    Export tax rebates are an important policy instrument for stimulating exports, which many developing countries make use of. However, excessive export tax rebates and inappropriate structural arrangements can lead to over-production in highly polluting industries and cause the environment to deteriorate. This paper, taking China as the study case, tests and verifies the statistical significance of the causal relationship between export tax rebates and pollution emissions. With a computable general equilibrium modeling, the current study further analyzes the effectiveness of export tax rebate adjustments aimed at alleviating environmental pressure for different time periods. It is found that before 2003, export tax rebates primarily promoted exports and boosted foreign exchange reserves, and highly polluting sectors enjoyed above-average export tax rebates, which led to increased pollution emissions. Between 2003 and 2010, the export tax rebate system was reformed to reduce support for the highly polluting export sectors, which led to decreases in emissions. Canceling export tax rebates for highly polluting sectors is shown to be the most favorable policy choice for improving the environmental performance of China's international trade. This study can serve as reference for other developing countries which similarly rely on export tax rebates, so that they can adjust their policies so as to combine economic growth with pollution control. Copyright © 2015 Elsevier Ltd. All rights reserved.

  11. 76 FR 4866 - Proposed Methodology for Implementation of Section 772(c)(2)(B) of the Tariff Act of 1930, as...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-27

    ... proposed methodological change to reduce the export price or constructed export price in certain non-market... Magnesium, as upheld in the Mag. Corp. cases, with respect to China and Vietnam. Accordingly, pursuant to... the price. In such cases, the Department would adjust the export price or constructed export price...

  12. An Analysis of Wood Pellets For Export: A Case Study of Sweden as an Importer

    Treesearch

    P.B. Aruna; Jan G. Laarman; Philip A. Araman; Frederick Cubbage

    1997-01-01

    North America is a major producer of wood pellets, and the principal market for them is domestic residential wood heating. To date, the export market for wood pellets is small. On the other hand , several developments are occurring that may be increasing the foreign demand for biomass fuels. A few North American companies are considering Sweden as a potential export...

  13. Utilizing chromophoric dissolved organic matter measurements to derive export and reactivity of dissolved organic carbon exported to the Arctic Ocean: A case study of the Yukon River, Alaska

    USGS Publications Warehouse

    Spencer, R.G.M.; Aiken, G.R.; Butler, K.D.; Dornblaser, M.M.; Striegl, Robert G.; Hernes, P.J.

    2009-01-01

    The quality and quantity of dissolved organic matter (DOM) exported by Arctic rivers is known to vary with hydrology and this exported material plays a fundamental role in the biogeochemical cycling of carbon at high latitudes. We highlight the potential of optical measurements to examine DOM quality across the hydrograph in Arctic rivers. Furthermore, we establish chromophoric DOM (CDOM) relationships to dissolved organic carbon (DOC) and lignin phenols in the Yukon River and model DOC and lignin loads from CDOM measurements, the former in excellent agreement with long-term DOC monitoring data. Intensive sampling across the historically under-sampled spring flush period highlights the importance of this time for total export of DOC and particularly lignin. Calculated riverine DOC loads to the Arctic Ocean show an increase from previous estimates, especially when new higher discharge data are incorporated. Increased DOC loads indicate decreased residence times for terrigenous DOM in the Arctic Ocean with important implications for the reactivity and export of this material to the Atlantic Ocean. Citation: Spencer, R. G. M., G. R. Aiken, K. D. Butler, M. M. Dornblaser, R. G. Striegl, and P. J. Hernes (2009), Utilizing chromophoric dissolved organic matter measurements to derive export and reactivity of dissolved organic carbon exported to the Arctic Ocean: A case study of the Yukon River, Alaska, Geophys. Res. Lett., 36, L06401, doi:10.1029/ 2008GL036831. Copyright 2009 by the American Geophysical Union.

  14. An Export-Marketing Model for Pharmaceutical Firms (The Case of Iran)

    PubMed Central

    Mohammadzadeh, Mehdi; Aryanpour, Narges

    2013-01-01

    Internationalization is a matter of committed decision-making that starts with export marketing, in which an organization tries to diagnose and use opportunities in target markets based on realistic evaluation of internal strengths and weaknesses with analysis of macro and microenvironments in order to gain presence in other countries. A developed model for export and international marketing of pharmaceutical companies is introduced. The paper reviews common theories of the internationalization process, followed by examining different methods and models for assessing preparation for export activities and examining conceptual model based on a single case study method on a basket of seven leading domestic firms by using mainly questionares as the data gathering tool along with interviews for bias reduction. Finally, in keeping with the study objectives, the special aspects of the pharmaceutical marketing environment have been covered, revealing special dimensions of pharmaceutical marketing that have been embedded within the appropriate base model. The new model for international activities of pharmaceutical companies was refined by expert opinions extracted from result of questionnaires. PMID:24250597

  15. An export-marketing model for pharmaceutical firms (the case of iran).

    PubMed

    Mohammadzadeh, Mehdi; Aryanpour, Narges

    2013-01-01

    Internationalization is a matter of committed decision-making that starts with export marketing, in which an organization tries to diagnose and use opportunities in target markets based on realistic evaluation of internal strengths and weaknesses with analysis of macro and microenvironments in order to gain presence in other countries. A developed model for export and international marketing of pharmaceutical companies is introduced. The paper reviews common theories of the internationalization process, followed by examining different methods and models for assessing preparation for export activities and examining conceptual model based on a single case study method on a basket of seven leading domestic firms by using mainly questionares as the data gathering tool along with interviews for bias reduction. Finally, in keeping with the study objectives, the special aspects of the pharmaceutical marketing environment have been covered, revealing special dimensions of pharmaceutical marketing that have been embedded within the appropriate base model. The new model for international activities of pharmaceutical companies was refined by expert opinions extracted from result of questionnaires.

  16. Land use mediates riverine nitrogen export under the dominant influence of human activities

    NASA Astrophysics Data System (ADS)

    Chen, Binhui; Chang, Scott X.; Lam, Shu Kee; Erisman, Jan Willem; Gu, Baojing

    2017-09-01

    Riverine nitrogen (N) export is a crucial process that links upstream and downstream ecosystems and coastal zones. However, the driving forces of riverine N export that is closely related to water N pollution are still not well understood. In this study, we used a mass balance approach to quantify the sources of N discharge and analyzed the effect of land use composition on riverine N export, taking Zhejiang Province, China as a case study. We found that the total reactive N discharge to rivers in Zhejiang increased from 0.22 to 0.26 Tg yr-1 from 2000 to 2015. At the watershed scale, our estimate of N export agrees well with the monitored riverine N concentration in the eight major watersheds in Zhejiang. Direct discharge of domestic wastewater and effluents from wastewater treatment plants are dominant sources of riverine N export, followed by agricultural non-point sources. Although riverine N export increases with the increasing proportion of urban and agricultural land uses, we did not find any relationship between land use change and changes in riverine N export. This suggests that the dominant factor affecting riverine N export should be human activities (e.g. wastewater discharge and fertilization level), while land use only mediates riverine N export.

  17. 22 CFR 123.9 - Country of ultimate destination and approval of reexports or retransfers.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... destination on an application for an export license, or on a Shipper's Export Declaration where an exemption... the export license, or on the Shipper's Export Declaration in cases where an exemption is claimed... the invoice whenever defense articles on the U.S. Munitions List are to be exported: These commodities...

  18. Case studies in international tobacco surveillance: cigarette smuggling in Brazil.

    PubMed

    Shafey, O; Cokkinides, V; Cavalcante, T M; Teixeira, M; Vianna, C; Thun, M

    2002-09-01

    This article is the first in a series of international case studies developed by the American Cancer Society to illustrate use of publicly available surveillance data for regional tobacco control. A descriptive analysis of Brazil and Paraguay cigarette production and trade data from official sources. Per capita cigarette consumption for Brazil and its neighbour was calculated from 1970 to 1998 using data on production, imports, and exports from NATIONS, the National Tobacco Information Online System. A 63% decrease was observed in the estimate of per capita consumption of cigarettes in Brazil between 1986 and 1998 (from 1913 cigarettes per person in 1986 to 714 cigarettes per person in 1998) and a 16-fold increase in Paraguay was observed during the same period (from 678 cigarettes per person in 1986 to 10 929 cigarettes per person in 1998). Following Brazil's 1999 passage of a 150% cigarette export tax, cigarette exports fell 89% and Brazil's estimated per capita consumption rose to 1990 levels (based on preliminary data). Per capita consumption in Paraguay also fell to 1990 levels. These trends coincide with local evidence that large volumes of cigarettes manufactured in Brazil for export to Paraguay are smuggled back and consumed as tax-free contraband in Brazil. It is hoped that this case study will draw wider public attention to the problems that smuggling presents for tobacco control, help identify other countries confronting similar issues, and stimulate effective interventions.

  19. Skill Acquisition in "High Tech" Export Agriculture: A Case Study of Lifelong Learning in Peru's Asparagus Industry

    ERIC Educational Resources Information Center

    Carnoy, Martin; Luschei, Thomas F.

    2008-01-01

    As one of the world's largest exporters of asparagus, Peru has developed a high-tech system of asparagus production, processing and delivery that requires well-trained and responsive workers. In this study we examine the role of both private and public sectors in preparing workers for the asparagus industry and the implications of this skill…

  20. Virtual water flows and water-footprint of agricultural crop production, import and export: A case study for Israel.

    PubMed

    Shtull-Trauring, E; Bernstein, N

    2018-05-01

    Agriculture is the largest global consumer of freshwater. As the volume of international trade continues to rise, so does the understanding that trade of water-intensive crops from areas with high precipitation, to arid regions can help mitigate water scarcity, highlighting the importance of crop water accounting. Virtual-Water, or Water-Footprint [WF] of agricultural crops, is a powerful indicator for assessing the extent of water use by plants, contamination of water bodies by agricultural practices and trade between countries, which underlies any international trade of crops. Most available studies of virtual-water flows by import/export of agricultural commodities were based on global databases, which are considered to be of limited accuracy. The present study analyzes the WF of crop production, import, and export on a country level, using Israel as a case study, comparing data from two high-resolution local databases and two global datasets. Results for local datasets demonstrate a WF of ~1200Million Cubic Meters [MCM]/year) for total crop production, ~1000MCM/year for import and ~250MCM/year for export. Fruits and vegetables comprise ~80% of Export WF (~200MCM/year), ~50% of crop production and only ~20% of the imports. Economic Water Productivity [EWP] ($/m 3 ) for fruits and vegetables is 1.5 higher compared to other crops. Moreover, the results based on local and global datasets varied significantly, demonstrating the importance of developing high-resolution local datasets based on local crop coefficients. Performing high resolution WF analysis can help in developing agricultural policies that include support for low WF/high EWP and limit high WF/low EWP crop export, where water availability is limited. Copyright © 2017 Elsevier B.V. All rights reserved.

  1. 19 CFR 351.519 - Remission or drawback of import charges upon export.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... export. 351.519 Section 351.519 Customs Duties INTERNATIONAL TRADE ADMINISTRATION, DEPARTMENT OF COMMERCE... Remission or drawback of import charges upon export. (a) Benefit—(1) In general. The term “remission or... import charges. In the case of the remission or drawback of import charges upon export, a benefit exists...

  2. 27 CFR 28.295 - Exception for export of beer.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... beer. 28.295 Section 28.295 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE... Alternate Procedures § 28.295 Exception for export of beer. The provisions of this subpart do not apply in the case of beer when the exporter or claimant obtains proof of exportation other than certification...

  3. 27 CFR 28.295 - Exception for export of beer.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... beer. 28.295 Section 28.295 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE... Alternate Procedures § 28.295 Exception for export of beer. The provisions of this subpart do not apply in the case of beer when the exporter or claimant obtains proof of exportation other than certification...

  4. 27 CFR 28.295 - Exception for export of beer.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... beer. 28.295 Section 28.295 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE... Alternate Procedures § 28.295 Exception for export of beer. The provisions of this subpart do not apply in the case of beer when the exporter or claimant obtains proof of exportation other than certification...

  5. 27 CFR 28.295 - Exception for export of beer.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... beer. 28.295 Section 28.295 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE... Alternate Procedures § 28.295 Exception for export of beer. The provisions of this subpart do not apply in the case of beer when the exporter or claimant obtains proof of exportation other than certification...

  6. 27 CFR 28.193 - Export marks.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Export marks. 28.193... Drawback Filing of Notice and Removal § 28.193 Export marks. In addition to the marks and brands required... chapter, the exporter shall mark the word “Export” on the Government side of each case or Government head...

  7. 27 CFR 28.295 - Exception for export of beer.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... beer. 28.295 Section 28.295 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE... Alternate Procedures § 28.295 Exception for export of beer. The provisions of this subpart do not apply in the case of beer when the exporter or claimant obtains proof of exportation other than certification...

  8. Case studies in international tobacco surveillance: cigarette smuggling in Brazil

    PubMed Central

    Shafey, O; Cokkinides, V; Cavalcante, T; Teixeira, M; Vianna, C; Thun, M

    2002-01-01

    Objective: This article is the first in a series of international case studies developed by the American Cancer Society to illustrate use of publicly available surveillance data for regional tobacco control. Design: A descriptive analysis of Brazil and Paraguay cigarette production and trade data from official sources. Methods: Per capita cigarette consumption for Brazil and its neighbour was calculated from 1970 to 1998 using data on production, imports, and exports from NATIONS, the National Tobacco Information Online System. Results: A 63% decrease was observed in the estimate of per capita consumption of cigarettes in Brazil between 1986 and 1998 (from 1913 cigarettes per person in 1986 to 714 cigarettes per person in 1998) and a 16-fold increase in Paraguay was observed during the same period (from 678 cigarettes per person in 1986 to 10 929 cigarettes per person in 1998). Following Brazil's 1999 passage of a 150% cigarette export tax, cigarette exports fell 89% and Brazil's estimated per capita consumption rose to 1990 levels (based on preliminary data). Per capita consumption in Paraguay also fell to 1990 levels. Conclusions: These trends coincide with local evidence that large volumes of cigarettes manufactured in Brazil for export to Paraguay are smuggled back and consumed as tax-free contraband in Brazil. It is hoped that this case study will draw wider public attention to the problems that smuggling presents for tobacco control, help identify other countries confronting similar issues, and stimulate effective interventions. PMID:12198271

  9. 19 CFR 351.515 - Internal transport and freight charges for export shipments.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 19 Customs Duties 3 2011-04-01 2011-04-01 false Internal transport and freight charges for export... Internal transport and freight charges for export shipments. (a) Benefit—(1) In general. In the case of internal transport and freight charges on export shipments, a benefit exists to the extent that the charges...

  10. 19 CFR 19.15 - Withdrawal for exportation of articles manufactured in bond; waste or byproducts for consumption.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... direct exportation, unless an authorization of the manufacturer is endorsed on the face of the withdrawal... be required as in the case of other warehouse withdrawals for exportation. (l) When the fact of... 19 Customs Duties 1 2010-04-01 2010-04-01 false Withdrawal for exportation of articles...

  11. Questioning the sustainable palm oil demand: case study from French-Indonesia supply chain

    NASA Astrophysics Data System (ADS)

    Chalil, D.; Barus, R.

    2018-02-01

    Sustainable palm oil has been widely debated. Consuming countries insist certified sustainable produces palm oil, but in fact the absorption of the certified palm oil is still less than 60%. This raise questions about the sustainable palm oil demand. In this study, such a condition will be analysed in French-Indonesia supply chain case. Using monthly and quarterly data from 2010 to 2016 with Autoregressive Distributed Lag (ARDL) approach and Error Correction Model, demand influencing factors and price integration in each market of the supply chain is estimated. Two scenarios namely re-export and direct export models are considered in the Error Correction Model. The results show that France Gross Domestic Product, prices of France palm oil import from Indonesia, Malaysia, and Germany, and price of France groundnut import significantly influence the France palm oil import volume from Indonesia. Prices in each market along palm oil re-export France-Indonesia supply chain are co-integrated and converge towards long-run equilibrium, but not in the direct export supply chain. This leads to a conclusion that France market preferences in specific and EU market preferences in general need to be considered by Indonesian palm oil decision makers.

  12. Salmon-mediated nutrient flux in selected streams of the Columbia River basin, USA

    USGS Publications Warehouse

    Kohler, Andre E.; Kusnierz, Paul C.; Copeland, Timothy; Venditti, David A.; Denny, Lytle; Gable, Josh; Lewis, Bert; Kinzer, Ryan; Barnett, Bruce; Wipfli, Mark S.

    2013-01-01

    Salmon provide an important resource subsidy and linkage between marine and land-based ecosystems. This flow of energy and nutrients is not uni-directional (i.e., upstream only); in addition to passive nutrient export via stream flow, juvenile emigrants actively export nutrients from freshwater environments. In some cases, nutrient export can exceed import. We evaluated nutrient fluxes in streams across central Idaho, USA using Chinook salmon (Oncorhynchus tshawytscha) adult escapement and juvenile production data from 1998 to 2008. We found in the majority of stream-years evaluated, adults imported more nutrients than progeny exported; however, in 3% of the years, juveniles exported more nutrients than their parents imported. On average, juvenile emigrants exported 22 ± 3% of the nitrogen and 30 ± 4% of the phosphorus their parents imported. This relationship was density dependent and nonlinear; during periods of low adult abundance juveniles were larger and exported up to 194% and 268% of parental nitrogen and phosphorus inputs, respectively. We highlight minimum escapement thresholds that appear to 1) maintain consistently positive net nutrient flux and 2) reduce the average proportional rate of export across study streams. Our results suggest a state-shift occurs when adult spawner abundance falls below a threshold to a point where the probability of juvenile nutrient exports exceeding adult imports becomes increasingly likely.

  13. Interagency Review of Prior Inspector General Recommendations Related to U.S. Export Controls. Volume I

    DTIC Science & Technology

    2008-09-01

    applications that require referral to the Office of Export Enforcement ( OEE ), and sends them simultaneously to OEE and licensing officers in Export...Enforcement ( OEE ) and the Office of Enforcement Analysis (OEA). We also spoke with staff from OEE ’ s Boston field office regarding closed...OExS staff should refer them to the Office of Export Enforcement ( OEE ). However, in the two cases of noncompliance, both exporters had shipped

  14. 19 CFR 351.520 - Export insurance.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Duties INTERNATIONAL TRADE ADMINISTRATION, DEPARTMENT OF COMMERCE ANTIDUMPING AND COUNTERVAILING DUTIES Identification and Measurement of Countervailable Subsidies § 351.520 Export insurance. (a) Benefit—(1) In general. In the case of export insurance, a benefit exists if the premium rates charged are inadequate to...

  15. 10 CFR 205.260 - Purpose and scope.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... DEPARTMENT OF ENERGY OIL ADMINISTRATIVE PROCEDURES AND SANCTIONS Procedures for Electricity Export Cases... followed by the Economic Regulatory Administration of the Department of Energy in electricity export..., as codified in 5 U.S.C. 551, 556, and 557, to consider an application to export electricity...

  16. 10 CFR 205.260 - Purpose and scope.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... DEPARTMENT OF ENERGY OIL ADMINISTRATIVE PROCEDURES AND SANCTIONS Procedures for Electricity Export Cases... followed by the Economic Regulatory Administration of the Department of Energy in electricity export..., as codified in 5 U.S.C. 551, 556, and 557, to consider an application to export electricity...

  17. 10 CFR 205.260 - Purpose and scope.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... DEPARTMENT OF ENERGY OIL ADMINISTRATIVE PROCEDURES AND SANCTIONS Procedures for Electricity Export Cases... followed by the Economic Regulatory Administration of the Department of Energy in electricity export..., as codified in 5 U.S.C. 551, 556, and 557, to consider an application to export electricity...

  18. 10 CFR 205.260 - Purpose and scope.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... DEPARTMENT OF ENERGY OIL ADMINISTRATIVE PROCEDURES AND SANCTIONS Procedures for Electricity Export Cases... followed by the Economic Regulatory Administration of the Department of Energy in electricity export..., as codified in 5 U.S.C. 551, 556, and 557, to consider an application to export electricity...

  19. 10 CFR 205.260 - Purpose and scope.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... DEPARTMENT OF ENERGY OIL ADMINISTRATIVE PROCEDURES AND SANCTIONS Procedures for Electricity Export Cases... followed by the Economic Regulatory Administration of the Department of Energy in electricity export..., as codified in 5 U.S.C. 551, 556, and 557, to consider an application to export electricity...

  20. Environmental implications of United States coal exports: a comparative life cycle assessment of future power system scenarios.

    PubMed

    Bohnengel, Barrett; Patiño-Echeverri, Dalia; Bergerson, Joule

    2014-08-19

    Stricter emissions requirements on coal-fired power plants together with low natural gas prices have contributed to a recent decline in the use of coal for electricity generation in the United States. Faced with a shrinking domestic market, many coal companies are taking advantage of a growing coal export market. As a result, U.S. coal exports hit an all-time high in 2012, fueled largely by demand in Asia. This paper presents a comparative life cycle assessment of two scenarios: a baseline scenario in which coal continues to be burned domestically for power generation, and an export scenario in which coal is exported to Asia. For the coal export scenario we focus on the Morrow Pacific export project being planned in Oregon by Ambre Energy that would ship 8.8 million tons of Powder River Basin (PRB) coal annually to Asian markets via rail, river barge, and ocean vessel. Air emissions (SOx, NOx, PM10 and CO2e) results assuming that the exported coal is burned for electricity generation in South Korea are compared to those of a business as usual case in which Oregon and Washington's coal plants, Boardman and Centralia, are retrofitted to comply with EPA emissions standards and continue their coal consumption. Findings show that although the environmental impacts of shipping PRB coal to Asia are significant, the combination of superior energy efficiency among newer South Korean coal-fired power plants and lower emissions from U.S. replacement of coal with natural gas could lead to a greenhouse gas reduction of 21% in the case that imported PRB coal replaces other coal sources in this Asian country. If instead PRB coal were to replace natural gas or nuclear generation in South Korea, greenhouse gas emissions per unit of electricity generated would increase. Results are similar for other air emissions such as SOx, NOx and PM. This study provides a framework for comparing energy export scenarios and highlights the importance of complete life cycle assessment in determining net emissions effects resulting from energy export projects and related policy decisions.

  1. 12 CFR 408.3 - Applicability.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Banking EXPORT-IMPORT BANK OF THE UNITED STATES PROCEDURES FOR COMPLIANCE WITH THE NATIONAL ENVIRONMENTAL... been in aid of U.S. exports which involve no effects on the quality of the environment within the... procedures set forth in this part apply to the relatively rare cases where Eximbank financing of U.S. exports...

  2. 15 CFR 746.4 - North Korea.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... requiring a license are subject to case-by-case review, except as follows: (1) Luxury Goods. Applications to... No. 1 to part 746. (2) Applications to export or reexport arms and related materiel are subject to a general policy of denial. In addition, applications to export or reexport items specified by UN documents...

  3. The spatial impact of neighbouring on the exports activities of COMESA countries by using spatial panel models

    NASA Astrophysics Data System (ADS)

    Hamzalouh, L.; Ismail, M. T.; Rahman, R. A.

    2017-09-01

    In this paper, spatial panel models were used and the method for selecting the best model amongst the spatial fixed effects model and the spatial random effects model to estimate the fitting model by using the robust Hausman test for analysis of the exports pattern of the Common Market for Eastern and Southern African (COMESA) countries. And examine the effects of the interactions of the economic statistic of explanatory variables on the exports of the COMESA. Results indicated that the spatial Durbin model with fixed effects specification should be tested and considered in most cases of this study. After that, the direct and indirect effects among COMESA regions were assessed, and the role of indirect spatial effects in estimating exports was empirically demonstrated. Regarding originality and research value, and to the best of the authors’ knowledge, this is the first attempt to examine exports between COMESA and its member countries through spatial panel models using XSMLE, which is a new command for spatial analysis using STATA.

  4. 19 CFR 351.517 - Exemption or remission upon export of indirect taxes.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... taxes. 351.517 Section 351.517 Customs Duties INTERNATIONAL TRADE ADMINISTRATION, DEPARTMENT OF COMMERCE... Exemption or remission upon export of indirect taxes. (a) Benefit. In the case of the exemption or remission upon export of indirect taxes, a benefit exists to the extent that the Secretary determines that the...

  5. 19 CFR 351.515 - Internal transport and freight charges for export shipments.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... shipments. 351.515 Section 351.515 Customs Duties INTERNATIONAL TRADE ADMINISTRATION, DEPARTMENT OF COMMERCE... Internal transport and freight charges for export shipments. (a) Benefit—(1) In general. In the case of internal transport and freight charges on export shipments, a benefit exists to the extent that the charges...

  6. 27 CFR 28.144 - Export marks.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Export marks. 28.144... § 28.144 Export marks. (a) General Requirement. In addition to the marks and brands required to be... brewer shall mark the word “Export” on each container or case of beer, or the words “Beer concentrate for...

  7. 19 CFR 351.222 - Revocation of orders; termination of suspended investigations.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    .... (ii) If the Secretary determines, based upon the criteria in paragraphs (b)(2)(i)(A) through (C) of..., the Secretary will revoke the order as to those producers or exporters. (3) Revocation of nonproducing exporter. In the case of an exporter that is not the producer of subject merchandise, the Secretary...

  8. 78 FR 78364 - Agency Information Collection Activities; Proposed Collection; Comment Request; Information From...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-26

    ....) firms/processors exporting shell eggs, dairy products, game meat, game meat products, animal casings... U.S. firms and processors that intended to export shell eggs, dairy products, and game meat and game... shell eggs, dairy products, game meat, game meat products, and animal casings: Business name and address...

  9. 7 CFR 1530.104 - Application for a license.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... OF AGRICULTURE THE REFINED SUGAR RE-EXPORT PROGRAM, THE SUGAR CONTAINING PRODUCTS RE-EXPORT PROGRAM... of any co-packer(s); (4) In the case of a refined sugar product, the polarity of the product and the formula proposed by the refiner for calculating the refined sugar in the product; (5) In the case of a...

  10. 7 CFR 1530.104 - Application for a license.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... OF AGRICULTURE THE REFINED SUGAR RE-EXPORT PROGRAM, THE SUGAR CONTAINING PRODUCTS RE-EXPORT PROGRAM... of any co-packer(s); (4) In the case of a refined sugar product, the polarity of the product and the formula proposed by the refiner for calculating the refined sugar in the product; (5) In the case of a...

  11. Export of nutrients and major ionic solutes from a rain forest catchment in the Central Amazon Basin

    NASA Astrophysics Data System (ADS)

    Lesack, Lance F. W.

    1993-03-01

    The relative roles of base flow runoff versus storm flow runoff versus subsurface outflow in controlling total export of solutes from a 23.4-ha catchment of undisturbed rain forest in the central Amazon Basin were evaluated from water and solute flux measurements performed over a 1 year period. Solutes exported via 173 storms during the study were estimated from stream water samples collected during base flow conditions and during eight storms, and by utilizing a hydrograph separation technique in combination with a mixing model to partition storm flow from base flow fluxes. Solutes exported by subsurface outflow were estimated from groundwater samples from three nests of piezometers installed into the streambed, and concurrent measurements of hydraulic conductivity and hydraulic head gradients. Base flow discharge represented 92% of water outflow from the basin and was the dominant pathway of solute export. Although storm flow discharge represented only 5% of total water outflow, storm flow solute fluxes represented up to 25% of the total annual export flux, though for many solutes the portion was less. Subsurface outflow represented only 2.5% of total water outflow, and subsurface solute fluxes never represented more than 5% of the total annual export flux. Measurement errors were relatively high for storm flow and subsurface outflow fluxes, but cumulative measurement errors associated with the total solute fluxes exported from the catchment, in most cases, ranged from only ±7% to 14% because base flow fluxes were measured relatively well. The export fluxes of most solutes are substantially less than previously reported for comparable small catchments in the Amazon basin, and these differences cannot be reconciled by the fact that storm flow and subsurface outflows were not appropriately measured in previous studies.

  12. Fish Rejections in the Marine Aquarium Trade: An Initial Case Study Raises Concern for Village-Based Fisheries

    PubMed Central

    Militz, Thane A.; Kinch, Jeff; Foale, Simon; Southgate, Paul C.

    2016-01-01

    A major difficulty in managing wildlife trade is the reliance on trade data (rather than capture data) to monitor exploitation of wild populations. Collected organisms that die or are rejected before a point of sale often go unreported. For the global marine aquarium trade, identifying the loss of collected fish from rejection, prior to export, is a first step in assessing true collection levels. This study takes a detailed look at fish rejections by buyers before export using the Papua New Guinea marine aquarium fishery as a case study. Utilizing collection invoices detailing the species and quantity of fish (Actinopteri and Elasmobranchii) accepted or rejected by the exporting company it was determined that, over a six month period, 24.2% of the total fish catch reported (n = 13,886) was rejected. Of the ten most collected fish families, rejection frequency was highest for the Apogonidae (54.2%), Chaetodontidae (26.3%), and Acanthuridae (18.2%) and lowest for Labridae (6.6%) and Hemiscylliidae (0.7%). The most frequently cited reasons for rejection were fin damage (45.6% of cases), undersized fish (21.8%), and fish deemed too thin (11.1%). Despite fishers receiving feedback on invoices explaining rejections, there was no improvement in rejection frequencies over time (r = -0.33, P = 0.15) with weekly rejection frequencies being highly inconsistent (range: 2.8% to 79.4%; s = 16.3%). These findings suggest that export/import statistics can greatly underestimate collection for the marine aquarium trade as additional factors such as fisher discards, escapees, post-collection mortalities, and unregulated domestic trade would further contribute to this disparity. PMID:26963259

  13. Fish Rejections in the Marine Aquarium Trade: An Initial Case Study Raises Concern for Village-Based Fisheries.

    PubMed

    Militz, Thane A; Kinch, Jeff; Foale, Simon; Southgate, Paul C

    2016-01-01

    A major difficulty in managing wildlife trade is the reliance on trade data (rather than capture data) to monitor exploitation of wild populations. Collected organisms that die or are rejected before a point of sale often go unreported. For the global marine aquarium trade, identifying the loss of collected fish from rejection, prior to export, is a first step in assessing true collection levels. This study takes a detailed look at fish rejections by buyers before export using the Papua New Guinea marine aquarium fishery as a case study. Utilizing collection invoices detailing the species and quantity of fish (Actinopteri and Elasmobranchii) accepted or rejected by the exporting company it was determined that, over a six month period, 24.2% of the total fish catch reported (n = 13,886) was rejected. Of the ten most collected fish families, rejection frequency was highest for the Apogonidae (54.2%), Chaetodontidae (26.3%), and Acanthuridae (18.2%) and lowest for Labridae (6.6%) and Hemiscylliidae (0.7%). The most frequently cited reasons for rejection were fin damage (45.6% of cases), undersized fish (21.8%), and fish deemed too thin (11.1%). Despite fishers receiving feedback on invoices explaining rejections, there was no improvement in rejection frequencies over time (r = -0.33, P = 0.15) with weekly rejection frequencies being highly inconsistent (range: 2.8% to 79.4%; s = 16.3%). These findings suggest that export/import statistics can greatly underestimate collection for the marine aquarium trade as additional factors such as fisher discards, escapees, post-collection mortalities, and unregulated domestic trade would further contribute to this disparity.

  14. Ramifications of Illegal U.S. Arms Exports

    DTIC Science & Technology

    1989-03-01

    the military goods may not have known and/or cared where their wares would ultimately be delivered. 5. U.S. v. Ken Park , aka Kwan Park, January 1989 The...revealed that Ken Park , acting as the Export Manager of Universal Technology, was involved in illegal export of aircraft parts to South Korea in August...transshipment to Teheran, Iran. On January 13, 1939, Ken Park admitted illegally exporting aircraft parts purchased from HTL. This case not only shows Iran’s

  15. 19 CFR 10.38 - Exportation.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... exportation entry. In such cases Customs Form 3495 shall be filed in triplicate. Articles entered under a... samples were entered under subheading 9813.00.20, HTSUS, or professional equipment or tools of trade were...

  16. 75 FR 28652 - Certain Environmental Goods: Probable Economic Effect of Duty-Free Treatment for U.S. Imports...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-21

    ...; and Prepare several case studies on the competitive position of selected U.S. environmental goods... environmental goods of significant export and/or commercial interest to the United States. Each case study will... appear at the public hearing. September 14, 2010: Deadline for filing pre-hearing briefs and statements...

  17. 21 CFR 1312.22 - Application for export permit.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... under international treaties, conventions, or protocols in effect on May 1, 1971. The affidavit shall... paragraphs (c) and (d) of this section. In the case of exportation of crude cocaine, the affidavit may state...

  18. 21 CFR 1312.22 - Application for export permit.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... under international treaties, conventions, or protocols in effect on May 1, 1971. The affidavit shall... paragraphs (c) and (d) of this section. In the case of exportation of crude cocaine, the affidavit may state...

  19. 21 CFR 1312.22 - Application for export permit.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... under international treaties, conventions, or protocols in effect on May 1, 1971. The affidavit shall... paragraphs (c) and (d) of this section. In the case of exportation of crude cocaine, the affidavit may state...

  20. 21 CFR 1312.22 - Application for export permit.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... under international treaties, conventions, or protocols in effect on May 1, 1971. The affidavit shall... paragraphs (c) and (d) of this section. In the case of exportation of crude cocaine, the affidavit may state...

  1. Carbon footprint of premium quality export bananas: case study in Ecuador, the world's largest exporter.

    PubMed

    Iriarte, Alfredo; Almeida, Maria Gabriela; Villalobos, Pablo

    2014-02-15

    Nowadays, the new international market demands challenge the food producing countries to include the measurement of the environmental impact generated along the production process for their products. In order to comply with the environmentally responsible market requests the measurement of the greenhouse gas emissions of Ecuadorian agricultural goods has been promoted employing the carbon footprint concept. Ecuador is the largest exporter of bananas in the world. Within this context, this study is a first assessment of the carbon footprint of the Ecuadorian premium export banana (Musa AAA) using a considerable amount of field data. The system boundaries considered from agricultural production to delivery in a European destination port. The data collected over three years permitted identifying the hot spot stages. For the calculation, the CCaLC V3.0 software developed by the University of Manchester is used. The carbon footprint of the Ecuadorian export banana ranged from 0.45 to 1.04 kg CO2-equivalent/kg banana depending on the international overseas transport employed. The principal contributors to the carbon footprint are the on farm production and overseas transport stages. Mitigation and reduction strategies were suggested for the main emission sources in order to achieve sustainable banana production. Copyright © 2013 Elsevier B.V. All rights reserved.

  2. Arms Sales: Congressional Review Process

    DTIC Science & Technology

    2015-12-17

    the Arms Export Control Act (AECA), Congress must be formally notified 30 calendar days before the Administration can take the final steps to...Commercially licensed arms sales also must be formally notified to Congress 30 calendar days before the export license is issued if they involve the sale...also be formally notified to Congress for review 30 days prior to the license for export being approved. In the case of proposed licences for such

  3. Effects of virtual water flow on regional water resources stress: A case study of grain in China.

    PubMed

    Sun, Shikun; Wang, Yubao; Engel, Bernie A; Wu, Pute

    2016-04-15

    Scarcity of water resources is one of the major challenges in the world, particularly for the main water consumer, agriculture. Virtual water flow (VWF) promotes water redistribution geographically and provides a new solution for resolving regional water shortage and improving water use efficiency in the world. Virtual water transfer among regions will have a significant influence on the water systems in both grain export and import regions. In order to assess the impacts of VWF related grain transfer on regional water resources conditions, the study takes mainland China as study area for a comprehensive evaluation of virtual water flow on regional water resources stress. Results show that Northeast China and Huang-Huai-Hai region are the major grain production regions as well as the major virtual water export regions. National water savings related to grain VWF was about 58Gm(3), with 48Gm(3) blue water and 10Gm(3) green water. VWF changes the original water distribution and has a significant effect on water resources in both virtual water import and export regions. Grain VWF significantly increased water stress in grain export regions and alleviated water stress in grain import regions. Water stress index (WSI) of Heilongjiang and Inner Mongolia has been increased by 138% and 129% due to grain export. Stress from water shortages is generally severe in export regions, and issues with the sustainability of grain production and VWF pattern are worthy of further exploration. Copyright © 2016 Elsevier B.V. All rights reserved.

  4. Attributing land-use change carbon emissions to exported biomass

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Saikku, Laura, E-mail: laura.saikku@helsinki.fi; Soimakallio, Sampo, E-mail: sampo.soimakallio@vtt.fi; Pingoud, Kim, E-mail: kim.pingoud@vtt.fi

    2012-11-15

    In this study, a simple, transparent and robust method is developed in which land-use change (LUC) emissions are retrospectively attributed to exported biomass products based on the agricultural area occupied for the production. LUC emissions account for approximately one-fifth of current greenhouse gas emissions. Increasing agricultural exports are becoming an important driver of deforestation. Brazil and Indonesia are used as case studies due to their significant deforestation in recent years. According to our study, in 2007, approximately 32% and 15% of the total agricultural land harvested and LUC emissions in Brazil and Indonesia respectively were due to exports. The mostmore » important exported single items with regard to deforestation were palm oil for Indonesia and bovine meat for Brazil. To reduce greenhouse gas (GHG) emissions effectively worldwide, leakage of emissions should be avoided. This can be done, for example, by attributing embodied LUC emissions to exported biomass products. With the approach developed in this study, controversial attribution between direct and indirect LUC and amortization of emissions over the product life cycle can be overcome, as the method operates on an average basis and annual level. The approach could be considered in the context of the UNFCCC climate policy instead of, or alongside with, other instruments aimed at reducing deforestation. However, the quality of the data should be improved and some methodological issues, such as the allocation procedure in multiproduct systems and the possible dilution effect through third parties not committed to emission reduction targets, should be considered. - Highlights: Black-Right-Pointing-Pointer CO{sub 2} emissions from land use changes are highly important. Black-Right-Pointing-Pointer Attribution of land use changes for products is difficult. Black-Right-Pointing-Pointer Simple and robust method is developed to attribute land use change emissions.« less

  5. Plankton networks driving carbon export in the oligotrophic ocean

    NASA Astrophysics Data System (ADS)

    Guidi, L.; Chaffron, S.; Bittner, L.; Eveillard, D.; Raes, J.; Karsenti, E.; Bowler, C.; Gorsky, G.

    2016-02-01

    The biological carbon pump is the process by which CO2 is transformed to organic carbon via photosynthesis that sinks to the deep ocean as particles where it is sequestered. While the intensity of the pump correlates with plankton community composition, the underlying ecosystem structure and interactions driving the process remain largely uncharacterised. Here we use environmental and metagenomic data gathered during the Tara Oceans expedition to improve our understanding of the underlying processes. We show that specific plankton communities correlate with carbon export and highlight unexpected and overlooked taxa such as Radiolaria, alveolate parasites, as well as Synechococcus and their phages, as lineages most strongly associated with carbon export in the subtropical oligotrophic ocean. Additionally, we show that the relative abundance of just a few bacterial and viral genes can predict most of the variability in carbon export in these regions. Together these results help elucidate ecosystem drivers of the biological carbon pump and present a case study for scaling from genes-to-ecosystems.

  6. Turning points in international labor migration: a case study of Thailand.

    PubMed

    Vasuprasat, P

    1994-01-01

    "This article describes the dynamics of the structural transformation of the Thai economy, labor migration and direct foreign investment and proposes an econometric model to explain the migration phenomenon. Though migration shifts have been significantly influenced by political factors such as the Gulf crisis and tensions with Saudi Arabia, economic factors such as the Thai government's liberalization of markets and the expansion of trade and direct foreign investment have contributed to changes in labor market needs. The economic conditions of a shift from net exporter to net importer for labor are posited in the model. The empirical results reveal a turning point in labor migration from Thailand and also confirm the contribution of commodity export in place of labor export in creating employment and income." excerpt

  7. An aminoacylation-dependent nuclear tRNA export pathway in yeast.

    PubMed

    Grosshans, H; Hurt, E; Simos, G

    2000-04-01

    Yeast Los1p, the homolog of human exportin-t, mediates nuclear export of tRNA. Using fluorescence in situ hybridization, we could show that the export of some intronless tRNA species is not detectably affected by the disruption of LOS1. To find other factors that facilitate tRNA export, we performed a suppressor screen of a synthetically lethal los1 mutant and identified the essential translation elongation factor eEF-1A. Mutations in eEF-1A impaired nuclear export of all tRNAs tested, which included both spliced and intronless species. An even stronger defect in nuclear exit of tRNA was observed under conditions that inhibited tRNA aminoacylation. In all cases, inhibition of tRNA export led to nucleolar accumulation of mature tRNAs. Our data show that tRNA aminoacylation and eEF-1A are required for efficient nuclear tRNA export in yeast and suggest coordination between the protein translation and the nuclear tRNA processing and transport machineries.

  8. An aminoacylation-dependent nuclear tRNA export pathway in yeast

    PubMed Central

    Grosshans, Helge; Hurt, Ed; Simos, George

    2000-01-01

    Yeast Los1p, the homolog of human exportin-t, mediates nuclear export of tRNA. Using fluorescence in situ hybridization, we could show that the export of some intronless tRNA species is not detectably affected by the disruption of LOS1. To find other factors that facilitate tRNA export, we performed a suppressor screen of a synthetically lethal los1 mutant and identified the essential translation elongation factor eEF-1A. Mutations in eEF-1A impaired nuclear export of all tRNAs tested, which included both spliced and intronless species. An even stronger defect in nuclear exit of tRNA was observed under conditions that inhibited tRNA aminoacylation. In all cases, inhibition of tRNA export led to nucleolar accumulation of mature tRNAs. Our data show that tRNA aminoacylation and eEF-1A are required for efficient nuclear tRNA export in yeast and suggest coordination between the protein translation and the nuclear tRNA processing and transport machineries. PMID:10766739

  9. Export Controls and Nonproliferation Policy

    DTIC Science & Technology

    1994-05-01

    Export Control Classification Numbers ( ECCNs ). The ECCNs do not correspond one-for-one to single commodity technology, or software items: in some...cases an ECCN covers only a single, narrowly defined item, but in many cases multiple related items fall under the same ECCN . The reason for control of...each ECCN category may be single or multiple (e.g., for both National Security and Nuclear Proliferation) but the reason(s) listed may in fact apply

  10. Catalytic and transport cycles of ABC exporters.

    PubMed

    Al-Shawi, Marwan K

    2011-09-07

    ABC (ATP-binding cassette) transporters are arguably the most important family of ATP-driven transporters in biology. Despite considerable effort and advances in determining the structures and physiology of these transporters, their fundamental molecular mechanisms remain elusive and highly controversial. How does ATP hydrolysis by ABC transporters drive their transport function? Part of the problem in answering this question appears to be a perceived need to formulate a universal mechanism. Although it has been generally hoped and assumed that the whole superfamily of ABC transporters would exhibit similar conserved mechanisms, this is proving not to be the case. Structural considerations alone suggest that there are three overall types of coupling mechanisms related to ABC exporters, small ABC importers and large ABC importers. Biochemical and biophysical characterization leads us to the conclusion that, even within these three classes, the catalytic and transport mechanisms are not fully conserved, but continue to evolve. ABC transporters also exhibit unusual characteristics not observed in other primary transporters, such as uncoupled basal ATPase activity, that severely complicate mechanistic studies by established methods. In this chapter, I review these issues as related to ABC exporters in particular. A consensus view has emerged that ABC exporters follow alternating-access switch transport mechanisms. However, some biochemical data suggest that alternating catalytic site transport mechanisms are more appropriate for fully symmetrical ABC exporters. Heterodimeric and asymmetrical ABC exporters appear to conform to simple alternating-access-type mechanisms.

  11. The Iranian petroleum crisis and United States national security.

    PubMed

    Stern, Roger

    2007-01-02

    The U.S. case against Iran is based on Iran's deceptions regarding nuclear weapons development. This case is buttressed by assertions that a state so petroleum-rich cannot need nuclear power to preserve exports, as Iran claims. The U.S. infers, therefore, that Iran's entire nuclear technology program must pertain to weapons development. However, some industry analysts project an Irani oil export decline [e.g., Clark JR (2005) Oil Gas J 103(18):34-39]. If such a decline is occurring, Iran's claim to need nuclear power could be genuine. Because Iran's government relies on monopoly proceeds from oil exports for most revenue, it could become politically vulnerable if exports decline. Here, we survey the political economy of Irani petroleum for evidence of this decline. We define Iran's export decline rate (edr) as its summed rates of depletion and domestic demand growth, which we find equals 10-12%. We estimate marginal cost per barrel for additions to Irani production capacity, from which we derive the "standstill" investment required to offset edr. We then compare the standstill investment to actual investment, which has been inadequate to offset edr. Even if a relatively optimistic schedule of future capacity addition is met, the ratio of 2011 to 2006 exports will be only 0.40-0.52. A more probable scenario is that, absent some change in Irani policy, this ratio will be 0.33-0.46 with exports declining to zero by 2014-2015. Energy subsidies, hostility to foreign investment, and inefficiencies of its state-planned economy underlie Iran's problem, which has no relation to "peak oil."

  12. Shift in performance of food safety management systems in supply chains: case of green bean chain in Kenya versus hot pepper chain in Uganda.

    PubMed

    Nanyunja, Jessica; Jacxsens, Liesbeth; Kirezieva, Klementina; Kaaya, Archileo N; Uyttendaele, Mieke; Luning, Pieternel A

    2016-08-01

    This study investigates the level of design and operation of food safety management systems (FSMS) of farmers and export traders in Kenya and Uganda. FSMS diagnostic tools developed for the fresh produce chain were used to assess the levels of context riskiness, FSMS activities and system output in primary production (n = 60) and trade (n = 60). High-risk context characteristics combined with basic FSMS are expected to increase the risk on unsafe produce. In Uganda both farmers and export traders of hot peppers operate in a high- to moderate-risk context but have basic FSMS and low systems output. In Kenya, both farmers and export traders of green beans operate in a low- to moderate-risk context. The farmers have average performing FSMS, whereas export trade companies showed more advanced FSMS and system output scores ranging from satisfactory to good. Large retailers supplying the EU premium market play a crucial role in demanding compliance with strict voluntary food safety standards, which was reflected in the more advanced FSMS and good system output in Kenya, especially traders. In Kenya, a clear shift in more fit-for-purpose FSMS and higher system output was noticed between farms and trade companies. In the case of Uganda, traders commonly supply to the less demanding EU wholesale markets such as ethnic specialty shops. They only have to comply with the legal phytosanitary and pesticide residue requirements for export activities, which apparently resulted in basic FSMS and low system output present with both farmers and traders. © 2015 Society of Chemical Industry. © 2015 Society of Chemical Industry.

  13. 10 CFR 110.42 - Export licensing criteria.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... the common defense and security. (2) The receiving country, after being advised of the information... such material, will be retransferred to the jurisdiction of any other country or group of countries... the case of facility exports, does not constitute an unreasonable risk to the public health and safety...

  14. 10 CFR 110.42 - Export licensing criteria.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... the common defense and security. (2) The receiving country, after being advised of the information... such material, will be retransferred to the jurisdiction of any other country or group of countries... the case of facility exports, does not constitute an unreasonable risk to the public health and safety...

  15. Pyruvate dehydrogenase complex (PDC) export from the mitochondrial matrix.

    PubMed

    Ng, Fanny; Tang, Bor Luen

    2014-01-01

    Studies on mitochondria protein import had revealed in detail molecular mechanisms of how peptides and proteins could be selectively targeted and translocated across membrane bound organelles. The opposite process of mitochondrial export, while known to occur in various aspects of cellular physiology and pathology, is less well understood. Two very recent reports have indicated that a large mitochondrial matrix protein complex, the pyruvate dehydrogenase complex (PDC) (or its component subunits), could be exported to the lysosomes and the nucleus, respectively. In the case of the latter, evidence was presented to suggest that the entire complex of 8-10 MDa could translocate in its entirety from the mitochondrial matrix to the nucleus upon mitogenic or stress stimuli. We discuss these findings in perspective to what is currently known about the processes of transport in and out of the mitochondrion.

  16. Analyzing the impacts of final demand changes on total output using input-output approach: The case of Japanese ICT sectors

    NASA Astrophysics Data System (ADS)

    Zuhdi, Ubaidillah

    2014-03-01

    The purpose of this study is to analyze the impacts of final demand changes on total output of Japanese Information and Communication Technologies (ICT) sectors in future time. This study employs one of analysis tool in Input-Output (IO) analysis, demand-pull IO quantity model, in achieving the purpose. There are three final demand changes used in this study, namely (1) export, (2) import, and (3) outside households consumption changes. This study focuses on "pure change" condition, the condition that final demand changes only appear in analyzed sectors. The results show that export and outside households consumption modifications give positive impact while opposite impact could be seen in import change.

  17. Export competitiveness of dairy products on global markets: the case of the European Union countries.

    PubMed

    Bojnec, Š; Fertő, I

    2014-10-01

    This paper analyzed the export competitiveness of dairy products of the European Union (EU) countries (EU-27) on intra-EU, extra-EU, and global markets, using the revealed comparative advantage index over the 2000-2011 period. The results indicated that about half of the EU-27 countries have had competitive exports in a certain segment of dairy products. The results differed by level of milk processing and for intra-EU and extra-EU markets, and did so over the analyzed years. Belgium, Denmark, France, Ireland, and the Netherlands are old EU-15 countries with competitive dairy exports (from the lowest to the highest according to the level of milk processing). The majority of the new EU-12 countries have faced difficulties in maintaining their level of export competitiveness, at least for some dairy products and market segments. The more competitive EU-12 countries in dairy exports were the Baltic States (Estonia, Latvia, and Lithuania) and Poland. The duration of export competitiveness differed across the dairy groups of products according to the level of milk processing, indicating the importance of dairy chain product differentiation for export competitiveness and specialization. The export competitiveness of the higher level of processed milk products for final consumption can be significant for export dairy chain competitiveness on global markets. Copyright © 2014 American Dairy Science Association. Published by Elsevier Inc. All rights reserved.

  18. 77 FR 73627 - 2012 LNG Export Study

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-11

    ... DEPARTMENT OF ENERGY 2012 LNG Export Study AGENCY: Office of Fossil Energy, Department of Energy. ACTION: Notice of availability of 2012 LNG Export Study and request for comments. Freeport LNG Expansion... liquefied natural gas (LNG) export cumulative impact study (LNG Export Study) in the above- referenced...

  19. 19 CFR 351.413 - Disregarding insignificant adjustments.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... any group of adjustments having an ad valorem effect of less than 1.0 percent, of the export price, constructed export price, or normal value, as the case may be. Groups of adjustments are adjustments for differences in circumstances of sale under § 351.410, adjustments for differences in the physical...

  20. The Iranian petroleum crisis and United States national security

    PubMed Central

    Stern, Roger

    2007-01-01

    The U.S. case against Iran is based on Iran's deceptions regarding nuclear weapons development. This case is buttressed by assertions that a state so petroleum-rich cannot need nuclear power to preserve exports, as Iran claims. The U.S. infers, therefore, that Iran's entire nuclear technology program must pertain to weapons development. However, some industry analysts project an Irani oil export decline [e.g., Clark JR (2005) Oil Gas J 103(18):34–39]. If such a decline is occurring, Iran's claim to need nuclear power could be genuine. Because Iran's government relies on monopoly proceeds from oil exports for most revenue, it could become politically vulnerable if exports decline. Here, we survey the political economy of Irani petroleum for evidence of this decline. We define Iran's export decline rate (edr) as its summed rates of depletion and domestic demand growth, which we find equals 10–12%. We estimate marginal cost per barrel for additions to Irani production capacity, from which we derive the “standstill” investment required to offset edr. We then compare the standstill investment to actual investment, which has been inadequate to offset edr. Even if a relatively optimistic schedule of future capacity addition is met, the ratio of 2011 to 2006 exports will be only 0.40–0.52. A more probable scenario is that, absent some change in Irani policy, this ratio will be 0.33–0.46 with exports declining to zero by 2014–2015. Energy subsidies, hostility to foreign investment, and inefficiencies of its state-planned economy underlie Iran's problem, which has no relation to “peak oil.” PMID:17190820

  1. Relationship between landscape characteristics and surface water quality.

    PubMed

    Chang, C L; Kuan, W H; Lui, P S; Hu, C Y

    2008-12-01

    The effects of landscape characteristics on surface water quality were evaluated in terms of land-use condition, soil type and slope. The case area, the Chichiawan stream in the Wulin catchment in Taiwan, is Formosan landlocked salmon's natural habitat. Due to the agriculture behavior and mankind's activities, the water and environmental quality has gradually worsened. This study applied WinVAST model to predict hydrological responses and non-point source pollution (NPSP) exports in the Wulin catchment. The land-use condition and the slope of land surface in a catchment are major effect factors for watershed responses, including flows and pollutant exports. This work discussed the possible variation of watershed responses induced by the change of land-use condition, soil type and slope, etc. The results show that hydrological responses are highly relative to the value of Curve Number (CN); Pollutant exports have large relation to the average slope of the land surface in the Wulin catchment.

  2. Dependent convergence: the importation of technological hazards by semiperipheral countries.

    PubMed

    Siqueira, C E; Levenstein, C

    2000-01-01

    This article complements the substantial body of literature produced over the last three decades on the export of hazards from developed countries to developing countries. After reviewing the central arguments proposed by this literature, the authors add to the debate by focusing on the role of national actors in the importation of these hazards, based on the experience of late 1970s' developments in the petrochemical industry in Brazil. The Brazilian case indicates that social struggles and/or interactions among actors in developing and developed nations determine to what extent hazardous technologies are imported without environmental controls and to what extent their hazardous effects are controlled by these nations. This study suggests that the future development of a more inclusive theory of export-import of hazardous technologies and products should take into account the dialectical relationship established between social actors internal to the exporting and importing countries.

  3. 19 CFR 10.248 - Additional requirements for preferential treatment of brassieres.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... the port of exportation; (C) In the case of fabric components purchased by the producer or entity... expenses for cutting or other processing to create the fabric components other than knitting to shape, that... shape, that the producer or entity controlling production can verify; or (2) If no exportation to an...

  4. 19 CFR 10.228 - Additional requirements for preferential treatment of brassieres.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... the port of exportation; (C) In the case of fabric components purchased by the producer or entity... expenses for cutting or other processing to create the fabric components other than knitting to shape, that... shape, that the producer or entity controlling production can verify; or (2) If no exportation to a...

  5. 19 CFR 10.228 - Additional requirements for preferential treatment of brassieres.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... the port of exportation; (C) In the case of fabric components purchased by the producer or entity... expenses for cutting or other processing to create the fabric components other than knitting to shape, that... shape, that the producer or entity controlling production can verify; or (2) If no exportation to a...

  6. 19 CFR 10.248 - Additional requirements for preferential treatment of brassieres.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... the port of exportation; (C) In the case of fabric components purchased by the producer or entity... expenses for cutting or other processing to create the fabric components other than knitting to shape, that... shape, that the producer or entity controlling production can verify; or (2) If no exportation to an...

  7. 19 CFR 351.516 - Price preferences for inputs used in the production of goods for export.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ..., DEPARTMENT OF COMMERCE ANTIDUMPING AND COUNTERVAILING DUTIES Identification and Measurement of...) Benefit—(1) In general. In the case of a program involving the provision by governments or their agencies... services for use in the production of exported goods, a benefit exists to the extent that the Secretary...

  8. Identification of Bicarbonate as a Trigger and Genes Involved with Extracellular DNA Export in Mycobacterial Biofilms.

    PubMed

    Rose, Sasha J; Bermudez, Luiz E

    2016-12-06

    Extracellular DNA (eDNA) is an integral biofilm matrix component of numerous pathogens, including nontuberculous mycobacteria (NTM). Cell lysis is the source of eDNA in certain bacteria, but the source of eDNA remains unidentified for NTM, as well as for other eDNA-containing bacterial species. In this study, conditions affecting eDNA export were examined, and genes involved with the eDNA export mechanism were identified. After a method for monitoring eDNA in real time in undisturbed biofilms was established, different conditions affecting eDNA were investigated. Bicarbonate positively influenced eDNA export in a pH-independent manner in Mycobacterium avium, M. abscessus, and M. chelonae The surface-exposed proteome of M. avium in eDNA-containing biofilms revealed abundant carbonic anhydrases. Chemical inhibition of carbonic anhydrases with ethoxzolamide significantly reduced eDNA export. An unbiased transposon mutant library screen for eDNA export in M. avium identified many severely eDNA-attenuated mutants, including one not expressing a unique FtsK/SpoIIIE-like DNA-transporting pore, two with inactivation of carbonic anhydrases, and nine with inactivation of genes belonging to a unique genomic region, as well as numerous mutants involved in metabolism and energy production. Complementation of nine mutants that included the FtsK/SpoIIIE and carbonic anhydrase significantly restored eDNA export. Interestingly, several attenuated eDNA mutants have mutations in genes encoding proteins that were found with the surface proteomics, and many more mutations are localized in operons potentially encoding surface proteins. Collectively, our data strengthen the evidence of eDNA export being an active mechanism that is activated by the bacterium responding to bicarbonate. Many bacteria contain extracellular DNA (eDNA) in their biofilm matrix, as it has various biological and physical functions. We recently reported that nontuberculous mycobacteria (NTM) can contain significant quantities of eDNA in their biofilms. In some bacteria, eDNA is derived from dead cells, but that does not appear to be the case for all eDNA-containing organisms, including NTM. In this study, we found that eDNA export in NTM is conditionally dependent on the molecules to which the bacteria are exposed and that bicarbonate positively influences eDNA export. We also identified genes and proteins important for eDNA export, which begins to piece together a description of a mechanism for eDNA. Better understanding of eDNA export can give new targets for the development of antivirulence drugs, which are attractive because resistance to classical antibiotics is currently a significant problem. Copyright © 2016 Rose and Bermudez.

  9. Exporters for Production of Amino Acids and Other Small Molecules.

    PubMed

    Eggeling, Lothar

    Microbes are talented catalysts to synthesize valuable small molecules in their cytosol. However, to make full use of their skills - and that of metabolic engineers - the export of intracellularly synthesized molecules to the culture medium has to be considered. This step is as essential as is each step for the synthesis of the favorite molecule of the metabolic engineer, but is frequently not taken into account. To export small molecules via the microbial cell envelope, a range of different types of carrier proteins is recognized to be involved, which are primary active carriers, secondary active carriers, or proteins increasing diffusion. Relevant export may require just one carrier as is the case with L-lysine export by Corynebacterium glutamicum or involve up to four carriers as known for L-cysteine excretion by Escherichia coli. Meanwhile carriers for a number of small molecules of biotechnological interest are recognized, like for production of peptides, nucleosides, diamines, organic acids, or biofuels. In addition to carriers involved in amino acid excretion, such carriers and their impact on product formation are described, as well as the relatedness of export carriers which may serve as a hint to identify further carriers required to improve product formation by engineering export.

  10. Price corrected domestic technology assumption--a method to assess pollution embodied in trade using primary official statistics only. With a case on CO2 emissions embodied in imports to Europe.

    PubMed

    Tukker, Arnold; de Koning, Arjan; Wood, Richard; Moll, Stephan; Bouwmeester, Maaike C

    2013-02-19

    Environmentally extended input output (EE IO) analysis is increasingly used to assess the carbon footprint of final consumption. Official EE IO data are, however, at best available for single countries or regions such as the EU27. This causes problems in assessing pollution embodied in imported products. The popular "domestic technology assumption (DTA)" leads to errors. Improved approaches based on Life Cycle Inventory data, Multiregional EE IO tables, etc. rely on unofficial research data and modeling, making them difficult to implement by statistical offices. The DTA can lead to errors for three main reasons: exporting countries can have higher impact intensities; may use more intermediate inputs for the same output; or may sell the imported products for lower/other prices than those produced domestically. The last factor is relevant for sustainable consumption policies of importing countries, whereas the first factors are mainly a matter of making production in exporting countries more eco-efficient. We elaborated a simple correction for price differences in imports and domestic production using monetary and physical data from official import and export statistics. A case study for the EU27 shows that this "price-adjusted DTA" gives a partial but meaningful adjustment of pollution embodied in trade compared to multiregional EE IO studies.

  11. Impact of Export Control and Technology Transfer Regimes: International Perspectives

    DTIC Science & Technology

    2012-01-07

    major national security and public policy issue. Exploring the ITAR environment through a set of case studies was the central idea in a project...cover) was based on a survey of UK stakeholders. The results were unambiguous and striking. Our British partners conclude ITAR is a good idea gone...ITAR) regime is a major national security and public policy issue. Exploring the ITAR environment through a set of case studies was the central idea

  12. Factorial study of rain garden design for nitrogen removal

    EPA Science Inventory

    Abstract Nitrate (〖NO〗_3^--N ) removal studies in bioretention systems showed great variability in removal rates and in some cases 〖NO〗_3^--N was exported. A 3-way factorial design (2 x 2 x 4) was devised for eight outdoor un-vegetated rain gardens to evaluate the effects of ...

  13. Regulating Cross-Border Higher Education: A Case Study of the United States

    ERIC Educational Resources Information Center

    Lane, Jason E.; Kinser, Kevin; Knox, Daniel

    2013-01-01

    In an increasing number of nations, foreign education providers are becoming part of the educational landscape. This aspect of cross-border higher education raises many questions about how such activities are regulated, particularly the role of the importing and exporting governments. Drawing on a principal-agent framework, this study uses the…

  14. 75 FR 18029 - Defense Federal Acquisition Regulation Supplement; Export-Controlled Items (DFARS Case 2004-D010)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-08

    ... increased security benefits will be reaped if DoD diligently identifies those portions of fundamental.... Fundamental Research and the Clause at DFARS 252.204-7000, Disclosure of Information Comments: The fundamental..., universities under contracts with DoD can and do have access to export-controlled items in fundamental research...

  15. 19 CFR 351.518 - Exemption, remission, or deferral upon export of prior-stage cumulative indirect taxes.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... prior-stage cumulative indirect taxes. 351.518 Section 351.518 Customs Duties INTERNATIONAL TRADE... indirect taxes. (a) Benefit—(1) Exemption of prior-stage cumulative indirect taxes. In the case of a... production of an exported product, a benefit exists to the extent that the exemption extends to inputs that...

  16. A simulation analysis of the fate of phytoplankton within the mid-Atlantic bight

    NASA Technical Reports Server (NTRS)

    Walsh, J. J.; Dieterle, D. A.; Meyers, M. B.

    1986-01-01

    A time-dependent, three-dimensional simulation model of wind-induced changes of the circulation field, of light and nutrient regulation of photosynthesis, of vertical mixing as well as algal sinking, and of herbivore grazing stress, is used to analyze the seasonal production, consumption, and transport of the spring bloom within the mid-Atlantic Bight. The particular case (c) of a 58-day period in February-April 1979, simulated primary production, based on both nitrate and recycled nitrogen, with a mean of 0.62 g C sq m/day over the whole model domain, and an export at the shelf-break off Long Island of 2.60 g ch1 sq m/day within the lower third of the water column. About 57% of the carbon fixation was removed by herbivores, with 21% lost as export, either downshelf or offshore to slope waters, after the first 58 days of the spring bloom. Extension of the model for another 22 days of case (c) increased the mean export to 27%, while variation of the model's parameters in 8 other cases led to a range in export from 8% to 38% of the average primary production. Spatial and temporal variations of the simulated albal biomass, left behind in the shelf water column, reproduced chlorophyll fields sensed by satellite, shipboard, and in situ instruments.

  17. The Political Economy of Biofuels and Farming: The Case of Smallholders in Tanzania

    NASA Astrophysics Data System (ADS)

    Winters, Kristen

    Following decades of neoliberal policies promoting commodity driven export production, the small scale farming sector in many developing countries has suffered from declining market share, lessening productivity and deepening poverty. In recent years, biofuels have been promoted within developing countries to foster rural development and provide new markets for the smallholders. Using Tanzania as a case study, this thesis evaluates the extent to which the emerging biofuel sector provides opportunities for smallholders to gain beneficial access to markets -- or whether the sector is following the trajectory of other export-oriented commodity projects of the past and resulting in the marginalisation of smallholders. This thesis asserts that the biofuel sector in Tanzania presents more threats than benefits for smallholders; a pattern can be witnessed that favours foreign investors and dispossesses farmers of existing land, while providing few opportunities at a local level for income generation and employment.

  18. Bipolar and Related Disorders Induced by Sodium 4-Phenylbutyrate in a Male Adolescent with Bile Salt Export Pump Deficiency Disease.

    PubMed

    Vitale, Giovanni; Simonetti, Giulia; Pirillo, Martina; Taruschio, Gianfranco; Andreone, Pietro

    2016-09-01

    Bile Salt Export Pump (BSEP) Deficiency disease, including Progressive Familial Intrahepatic Cholestasis type 2 (PFIC2), is a rare disease, usually leading within the first ten years to portal hypertension, liver failure, hepatocellular carcinoma. Often liver transplantation is needed. Sodium 4-phenylbutyrate (4-PB) seems to be a potential therapeutic compound for PFIC2. Psychiatric side effects in the adolescent population are little known and little studied since the drug used to treat children and infants. So we described a case of Caucasian boy, suffering from a late onset PFIC2, listed for a liver transplant when he was sixteen and treated with 4-FB (200 mg per kilogram of body weight per day). The drug was discontinued for the onset of bipolar and related disorders. This case illustrates possible psychiatric side effects of the drug.

  19. Bayesian Networks to Compare Pest Control Interventions on Commodities Along Agricultural Production Chains.

    PubMed

    Holt, J; Leach, A W; Johnson, S; Tu, D M; Nhu, D T; Anh, N T; Quinlan, M M; Whittle, P J L; Mengersen, K; Mumford, J D

    2018-02-01

    The production of an agricultural commodity involves a sequence of processes: planting/growing, harvesting, sorting/grading, postharvest treatment, packing, and exporting. A Bayesian network has been developed to represent the level of potential infestation of an agricultural commodity by a specified pest along an agricultural production chain. It reflects the dependency of this infestation on the predicted level of pest challenge, the anticipated susceptibility of the commodity to the pest, the level of impact from pest control measures as designed, and any variation from that due to uncertainty in measure efficacy. The objective of this Bayesian network is to facilitate agreement between national governments of the exporters and importers on a set of phytosanitary measures to meet specific phytosanitary measure requirements to achieve target levels of protection against regulated pests. The model can be used to compare the performance of different combinations of measures under different scenarios of pest challenge, making use of available measure performance data. A case study is presented using a model developed for a fruit fly pest on dragon fruit in Vietnam; the model parameters and results are illustrative and do not imply a particular level of fruit fly infestation of these exports; rather, they provide the most likely, alternative, or worst-case scenarios of the impact of measures. As a means to facilitate agreement for trade, the model provides a framework to support communication between exporters and importers about any differences in perceptions of the risk reduction achieved by pest control measures deployed during the commodity production chain. © 2017 Society for Risk Analysis.

  20. Expanding Integrated Pest Management Capacity: Rwanda Case Study

    ERIC Educational Resources Information Center

    Baributsa, Dieudonne; Flores, Luis; Rukazambuga, Daniel; Wise, John C.

    2014-01-01

    Purpose: Rwanda is developing its agricultural capacity to meet the needs of national food security while addressing food demands and requirements of regional and international markets. The Rwanda Horticultural Export Standards Initiative was developed by the Ministry of Agriculture and Natural Resources in collaboration with Michigan State…

  1. Higher Education Exports in South Africa: A Case Study of Stellenbosch University

    ERIC Educational Resources Information Center

    du Plessis, E.; Fourie, J.

    2011-01-01

    International trade in higher education services is one of the fastest growing tradable service sectors globally. Apart from the positive externalities international students create through knowledge mobility and spill-over, campus diversity, and local community development participation, spending by international students in the host city and…

  2. Fluid flow enhances the effectiveness of toxin export by aquatic microorganisms: A first-passage perspective on microvilli and the concentration boundary layer

    NASA Astrophysics Data System (ADS)

    Licata, Nicholas A.; Clark, Aaron

    2015-01-01

    A central challenge for organisms during development is determining a means to efficiently export toxic molecules from inside the developing embryo. For aquatic microorganisms, the strategies employed should be robust with respect to the variable ocean environment and limit the chances that exported toxins are reabsorbed. As a result, the problem of toxin export is closely related to the physics of mass transport in a fluid. In this paper, we consider a model first-passage problem for the uptake of exported toxins by a spherical embryo. By considering how macroscale fluid turbulence manifests itself on the microscale of the embryo, we determine that fluid flow enhances the effectiveness of toxin export as compared to the case of diffusion-limited transport. In the regime of a large Péclet number, a perturbative solution of the advection-diffusion equation reveals that a concentration boundary layer forms at the surface of the embryo. The model results suggest a functional role for cell surface roughness in the export process, with the thickness of the concentration boundary layer setting the length scale for cell membrane protrusions known as microvilli. We highlight connections between the model results and experiments on the development of sea urchin embryos.

  3. Microinjection and Fluorescence In Situ Hybridization Assay for Studying mRNA Export in Mammalian Cells.

    PubMed

    Wang, Ke; Shi, Min; Cheng, Hong

    2017-01-01

    Microinjection and Fluorescence in situ Hybridization (FISH) assay is a useful method for mRNA export studies, which can overcome the problems of traditional transfection in cells. Here, we describe the method of microinjection and FISH assay applied in investigation of mRNA export. By this method we can estimate the mRNA export kinetics, examining mRNA export in cells with low transfection efficiencies, and observing nuclear export of aberrant RNAs.

  4. Big Sugar in southern Africa: rural development and the perverted potential of sugar/ethanol exports.

    PubMed

    Richardson, Ben

    2010-01-01

    This paper asks how investment in large-scale sugar cane production has contributed, and will contribute, to rural development in southern Africa. Taking a case study of the South African company Illovo in Zambia, the argument is made that the potential for greater tax revenue, domestic competition, access to resources and wealth distribution from sugar/ethanol production have all been perverted and with relatively little payoff in wage labour opportunities in return. If the benefits of agro-exports cannot be so easily assumed, then the prospective 'balance sheet' of biofuels needs to be re-examined. In this light, the paper advocates smaller-scale agrarian initiatives.

  5. 31 CFR 515.578 - Exportation of certain services incident to Internet-based communications.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Cuba, as defined in § 515.337 of this part, or a prohibited member of the Cuban Communist Party, as defined in § 515.338 of this part. (2) The direct or indirect exportation of Internet connectivity... software, to Cuba, see §§ 515.533 and 515.559 of this part. (c) Specific licenses may be issued on a case...

  6. 31 CFR 515.578 - Exportation of certain services incident to Internet-based communications.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Cuba, as defined in § 515.337 of this part, or a prohibited member of the Cuban Communist Party, as defined in § 515.338 of this part. (2) The direct or indirect exportation of Internet connectivity... software, to Cuba, see §§ 515.533 and 515.559 of this part. (c) Specific licenses may be issued on a case...

  7. 31 CFR 515.578 - Exportation of certain services incident to Internet-based communications.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Cuba, as defined in § 515.337 of this part, or a prohibited member of the Cuban Communist Party, as defined in § 515.338 of this part. (2) The direct or indirect exportation of Internet connectivity... software, to Cuba, see §§ 515.533 and 515.559 of this part. (c) Specific licenses may be issued on a case...

  8. Trading forests: land-use change and carbon emissions embodied in production and exports of forest-risk commodities

    NASA Astrophysics Data System (ADS)

    Henders, Sabine; Persson, U. Martin; Kastner, Thomas

    2015-12-01

    Production of commercial agricultural commodities for domestic and foreign markets is increasingly driving land clearing in tropical regions, creating links and feedback effects between geographically separated consumption and production locations. Such teleconnections are commonly studied through calculating consumption footprints and quantifying environmental impacts embodied in trade flows, e.g., virtual water and land, biomass, or greenhouse gas emissions. The extent to which land-use change (LUC) and associated carbon emissions are embodied in the production and export of agricultural commodities has been less studied. Here we quantify tropical deforestation area and carbon emissions from LUC induced by the production and the export of four commodities (beef, soybeans, palm oil, and wood products) in seven countries with high deforestation rates (Argentina, Bolivia, Brazil, Paraguay, Indonesia, Malaysia, and Papua New Guinea). We show that in the period 2000-2011, the production of the four analyzed commodities in our seven case countries was responsible for 40% of total tropical deforestation and resulting carbon losses. Over a third of these impacts was embodied in exports in 2011, up from a fifth in 2000. This trend highlights the growing influence of global markets in deforestation dynamics. Main flows of embodied LUC are Latin American beef and soybean exports to markets in Europe, China, the former Soviet bloc, the Middle East and Northern Africa, whereas embodied emission flows are dominated by Southeast Asian exports of palm oil and wood products to consumers in China, India and the rest of Asia, as well as to the European Union. Our findings illustrate the growing role that global consumers play in tropical LUC trajectories and highlight the need for demand-side policies covering whole supply chains. We also discuss the limitations of such demand-side measures and call for a combination of supply- and demand-side policies to effectively limit tropical deforestation, along with research into the interactions of different types of policy interventions.

  9. Nucleocytoplasmic Transport of RNAs and RNA-Protein Complexes.

    PubMed

    Sloan, Katherine E; Gleizes, Pierre-Emmanuel; Bohnsack, Markus T

    2016-05-22

    RNAs and ribonucleoprotein complexes (RNPs) play key roles in mediating and regulating gene expression. In eukaryotes, most RNAs are transcribed, processed and assembled with proteins in the nucleus and then either function in the cytoplasm or also undergo a cytoplasmic phase in their biogenesis. This compartmentalization ensures that sequential steps in gene expression and RNP production are performed in the correct order and it allows important quality control mechanisms that prevent the involvement of aberrant RNAs/RNPs in these cellular pathways. The selective exchange of RNAs/RNPs between the nucleus and cytoplasm is enabled by nuclear pore complexes, which function as gateways between these compartments. RNA/RNP transport is facilitated by a range of nuclear transport receptors and adaptors, which are specifically recruited to their cargos and mediate interactions with nucleoporins to allow directional translocation through nuclear pore complexes. While some transport factors are only responsible for the export/import of a certain class of RNA/RNP, others are multifunctional and, in the case of large RNPs, several export factors appear to work together to bring about export. Recent structural studies have revealed aspects of the mechanisms employed by transport receptors to enable specific cargo recognition, and genome-wide approaches have provided the first insights into the diverse composition of pre-mRNPs during export. Furthermore, the regulation of RNA/RNP export is emerging as an important means to modulate gene expression under stress conditions and in disease. Copyright © 2015. Published by Elsevier Ltd.

  10. Test-Case Generation using an Explicit State Model Checker Final Report

    NASA Technical Reports Server (NTRS)

    Heimdahl, Mats P. E.; Gao, Jimin

    2003-01-01

    In the project 'Test-Case Generation using an Explicit State Model Checker' we have extended an existing tools infrastructure for formal modeling to export Java code so that we can use the NASA Ames tool Java Pathfinder (JPF) for test case generation. We have completed a translator from our source language RSML(exp -e) to Java and conducted initial studies of how JPF can be used as a testing tool. In this final report, we provide a detailed description of the translation approach as implemented in our tools.

  11. Small Country, Big Business? New Zealand as Education Exporter

    ERIC Educational Resources Information Center

    Martens, Kerstin; Starke, Peter

    2008-01-01

    This paper discusses New Zealand's role in the global market for tertiary education. The internationalisation and liberalisation of education markets is progressing rapidly in today's globalising world, as reflected by the incorporation of education as a service into the GATS framework. Through the example of New Zealand as a case study for the…

  12. Sub-Saharan Africa report, [January 29, 1987

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    NONE

    1987-01-29

    Partial Contents: Subsaharan Africa, resolution, settlement, leaderships, election fraud, political, propaganda war, guerrilla war, commonwealth president, warns officers, national youth corps, diversity, unemployment, fuel consumption, journalists, cultural agreement, steel plants, foreign investment, energy, fuel shortage, fertilizer, export, telecommunication, defense workers, farming, private school, educational, scholarships, case study, government, economics, political philosophy, sociopolitical, industrial.

  13. China-U.S. Trade Issues

    DTIC Science & Technology

    2009-03-04

    failure in some cases to ensure that its exported products meet U.S. health and safety standards. Further complicating the bilateral economic...dispute resolution cases against China in the WTO, and continuing pressure on China to appreciate its currency. Others have warned against using...15 Pending Cases

  14. NES consensus redefined by structures of PKI-type and Rev-type nuclear export signals bound to CRM1.

    PubMed

    Güttler, Thomas; Madl, Tobias; Neumann, Piotr; Deichsel, Danilo; Corsini, Lorenzo; Monecke, Thomas; Ficner, Ralf; Sattler, Michael; Görlich, Dirk

    2010-11-01

    Classic nuclear export signals (NESs) confer CRM1-dependent nuclear export. Here we present crystal structures of the RanGTP-CRM1 complex alone and bound to the prototypic PKI or HIV-1 Rev NESs. These NESs differ markedly in the spacing of their key hydrophobic (Φ) residues, yet CRM1 recognizes them with the same rigid set of five Φ pockets. The different Φ spacings are compensated for by different conformations of the bound NESs: in the case of PKI, an α-helical conformation, and in the case of Rev, an extended conformation with a critical proline docking into a Φ pocket. NMR analyses of CRM1-bound and CRM1-free PKI NES suggest that CRM1 selects NES conformers that pre-exist in solution. Our data lead to a new structure-based NES consensus, and explain why NESs differ in their affinities for CRM1 and why supraphysiological NESs bind the exportin so tightly.

  15. The freshwater export from the Arctic Ocean and the circulation of liquid freshwater around Greenland - constraints, interactions & consequences

    NASA Astrophysics Data System (ADS)

    Rudels, Bert

    2010-05-01

    The freshwater added to the Arctic Ocean is stored as sea ice and as liquid freshwater residing primarily in the upper layers. This allows for simple zero order estimates of the liquid freshwater content and export based on rotationally controlled baroclinic flow. At present the freshwater outflow occurs on both sides of Greenland. In Fram Strait the sea ice export in the East Greenland Current is significantly larger than the liquid freshwater outflow, while the liquid freshwater export dominates in the Canadian Arctic Archipelago. Although the outflow in the upper layer and the freshwater export respond to short periodic wind events and longer periodic atmospheric circulation patterns, the long-term trend is controlled by the net freshwater supply - the freshwater input minus the ice export. As the ice formation and ice export are expected to diminish in a warmer climate the Canadian Arctic Archipelago, comprising several passages, should gradually carry more of the total Arctic Ocean freshwater outflow. However, the channels in the Canadian Arctic Archipelago discharge into the restricted Baffin, which also receives a part of the Fram Strait freshwater export via the West Greenland Current. In a situation with increased glacial melting and freshwater discharge from Greenland the density of the upper layer in Baffin Bay may decrease considerably. This would reduce the sea level difference between the Arctic Ocean and Baffin Bay and thus weaken the outflow through the Canadian Arctic Archipelago, in extreme cases perhaps even reverse the flow. This would shift the main Arctic Ocean liquid freshwater export from The Canadian Arctic Archipelago to Fram Strait. The zero order dynamics of the exchanges through the Canadian Arctic Archipelago and Baffin Bay are described and the possibility for a weakening of the outflow is examined.

  16. In Vitro Comparison of Adipokine Export Signals.

    PubMed

    Sharafi, Parisa; Kocaefe, Y Çetin

    2016-01-01

    Mammalian cells are widely used for recombinant protein production in research and biotechnology. Utilization of export signals significantly facilitates production and purification processes. 35 years after the discovery of the mammalian export machinery, there still are obscurities regarding the efficiency of the export signals. The aim of this study was the comparative evaluation of the efficiency of selected export signals using adipocytes as a cell model. Adipocytes have a large capacity for protein secretion including several enzymes, adipokines, and other signaling molecules, providing a valid system for a quantitative evaluation. Constructs that expressed N-terminal fusion export signals were generated to express Enhanced Green Fluorescence Protein (EGFP) as a reporter for quantitative and qualitative evaluation. Furthermore, fluorescent microscopy was used to trace the intracellular traffic of the reporter. The export efficiency of six selected proteins secreted from adipocytes was evaluated. Quantitative comparison of intracellular and exported fractions of the recombinant constructs demonstrated a similar efficiency among the studied sequences with minor variations. The export signal of Retinol Binding Protein (RBP4) exhibited the highest efficiency. This study presents the first quantitative data showing variations among export signals, in adipocytes which will help optimization of recombinant protein distribution.

  17. 31 CFR 545.514 - Payments for services rendered by the Taliban to aircraft.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...) SANCTIONS REGULATIONS Licenses, Authorizations and Statements of Licensing Policy § 545.514 Payments for services rendered by the Taliban to aircraft. (a) Specific licenses may be issued on a case-by-case basis.... (b) Specific licenses may be issued on a case-by-case basis for the exportation, reexportation, sale...

  18. China-U.S. Trade Issues

    DTIC Science & Technology

    2009-03-31

    failure in some cases to ensure that its exported products meet U.S. health and safety standards. Further complicating the bilateral economic...resolution cases against China in the WTO, and continuing pressure on China to appreciate its currency. Others have warned against using...14 WTO Implementation Issues................................................................................................... 15 Pending Cases

  19. UAV-Based Estimation of Carbon Exports from Heterogeneous Soil Landscapes—A Case Study from the CarboZALF Experimental Area

    PubMed Central

    Wehrhan, Marc; Rauneker, Philipp; Sommer, Michael

    2016-01-01

    The advantages of remote sensing using Unmanned Aerial Vehicles (UAVs) are a high spatial resolution of images, temporal flexibility and narrow-band spectral data from different wavelengths domains. This enables the detection of spatio-temporal dynamics of environmental variables, like plant-related carbon dynamics in agricultural landscapes. In this paper, we quantify spatial patterns of fresh phytomass and related carbon (C) export using imagery captured by a 12-band multispectral camera mounted on the fixed wing UAV Carolo P360. The study was performed in 2014 at the experimental area CarboZALF-D in NE Germany. From radiometrically corrected and calibrated images of lucerne (Medicago sativa), the performance of four commonly used vegetation indices (VIs) was tested using band combinations of six near-infrared bands. The highest correlation between ground-based measurements of fresh phytomass of lucerne and VIs was obtained for the Enhanced Vegetation Index (EVI) using near-infrared band b899. The resulting map was transformed into dry phytomass and finally upscaled to total C export by harvest. The observed spatial variability at field- and plot-scale could be attributed to small-scale soil heterogeneity in part. PMID:26907284

  20. UAV-Based Estimation of Carbon Exports from Heterogeneous Soil Landscapes--A Case Study from the CarboZALF Experimental Area.

    PubMed

    Wehrhan, Marc; Rauneker, Philipp; Sommer, Michael

    2016-02-19

    The advantages of remote sensing using Unmanned Aerial Vehicles (UAVs) are a high spatial resolution of images, temporal flexibility and narrow-band spectral data from different wavelengths domains. This enables the detection of spatio-temporal dynamics of environmental variables, like plant-related carbon dynamics in agricultural landscapes. In this paper, we quantify spatial patterns of fresh phytomass and related carbon (C) export using imagery captured by a 12-band multispectral camera mounted on the fixed wing UAV Carolo P360. The study was performed in 2014 at the experimental area CarboZALF-D in NE Germany. From radiometrically corrected and calibrated images of lucerne (Medicago sativa), the performance of four commonly used vegetation indices (VIs) was tested using band combinations of six near-infrared bands. The highest correlation between ground-based measurements of fresh phytomass of lucerne and VIs was obtained for the Enhanced Vegetation Index (EVI) using near-infrared band b899. The resulting map was transformed into dry phytomass and finally upscaled to total C export by harvest. The observed spatial variability at field- and plot-scale could be attributed to small-scale soil heterogeneity in part.

  1. The pulse of driftwood export from a very large forested river basin over multiple time scales, Slave River, Canada

    NASA Astrophysics Data System (ADS)

    Kramer, Natalie; Wohl, Ellen; Hess-Homeier, Brooke; Leisz, Stephen

    2017-03-01

    This study presents a case study of large wood transport on the great Slave River in northern Canada with the objective to better understand the processes of and variability in pulsed wood fluxes from large forested catchments. We use a varied approach, integrating field characterization of wood, historical anecdotes, repeat aerial imagery of stored wood, and time-lapse imagery of moving wood, for a robust analysis and synthesis of processes behind pulsed wood flux, from yearly uncongested export to rare congested wood floods. Repeat monitoring of known sites of temporary storage with new or historic imagery proved to be a very useful tool for constraining wood flux histories. Pulsed wood export on the Slave River is not an artifact of episodic recruitment from major up-basin disturbances, but rather reflects decadal- to half-century-scale discharge patterns that redistribute wood recruited from channel migration and bank slumping. We suggest that the multiyear flow history is of paramount importance for estimating wood flux magnitude, followed in declining importance by the yearly sequence of peaks and the magnitude and characteristics of the rising limb of individual floods.

  2. Ornamental marine species culture in the coral triangle: seahorse demonstration project in the Spermonde Islands, Sulawesi, Indonesia.

    PubMed

    Williams, Susan L; Janetski, Noel; Abbott, Jessica; Blankenhorn, Sven; Cheng, Brian; Crafton, R Eliot; Hameed, Sarah O; Rapi, Saipul; Trockel, Dale

    2014-12-01

    Ornamental marine species ('OMS') provide valuable income for developing nations in the Indo-Pacific Coral Triangle, from which most of the specimens are exported. OMS culture can help diversify livelihoods in the region, in support of management and conservation efforts to reduce destructive fishing and collection practices that threaten coral reef and seagrass ecosystems. Adoption of OMS culture depends on demonstrating its success as a livelihood, yet few studies of OMS culture exist in the region. We present a case study of a land-based culture project for an endangered seahorse (Hippocampus barbouri) in the Spermonde Islands, Sulawesi, Indonesia. The business model demonstrated that culturing can increase family income by seven times. A Strengths Weaknesses Opportunities Threats (SWOT) analysis indicated good collaboration among diverse stakeholders and opportunities for culturing non-endangered species and for offshoot projects, but complicated permitting was an issue as were threats of market flooding and production declines. The OMS international market is strong, Indonesian exporters expressed great interest in cultured product, and Indonesia is the largest exporting country for H. barbouri. Yet, a comparison of Indonesia ornamental marine fish exports to fish abundance in a single local market indicated that OMS culture cannot replace fishing livelihoods. Nevertheless, seahorse and other OMS culture can play a role in management and conservation by supplementing and diversifying the fishing and collecting livelihoods in the developing nations that provide the majority of the global OMS.

  3. Ornamental Marine Species Culture in the Coral Triangle: Seahorse Demonstration Project in the Spermonde Islands, Sulawesi, Indonesia

    NASA Astrophysics Data System (ADS)

    Williams, Susan L.; Janetski, Noel; Abbott, Jessica; Blankenhorn, Sven; Cheng, Brian; Crafton, R. Eliot; Hameed, Sarah O.; Rapi, Saipul; Trockel, Dale

    2014-12-01

    Ornamental marine species (`OMS') provide valuable income for developing nations in the Indo-Pacific Coral Triangle, from which most of the specimens are exported. OMS culture can help diversify livelihoods in the region, in support of management and conservation efforts to reduce destructive fishing and collection practices that threaten coral reef and seagrass ecosystems. Adoption of OMS culture depends on demonstrating its success as a livelihood, yet few studies of OMS culture exist in the region. We present a case study of a land-based culture project for an endangered seahorse ( Hippocampus barbouri) in the Spermonde Islands, Sulawesi, Indonesia. The business model demonstrated that culturing can increase family income by seven times. A Strengths Weaknesses Opportunities Threats (SWOT) analysis indicated good collaboration among diverse stakeholders and opportunities for culturing non-endangered species and for offshoot projects, but complicated permitting was an issue as were threats of market flooding and production declines. The OMS international market is strong, Indonesian exporters expressed great interest in cultured product, and Indonesia is the largest exporting country for H. barbouri. Yet, a comparison of Indonesia ornamental marine fish exports to fish abundance in a single local market indicated that OMS culture cannot replace fishing livelihoods. Nevertheless, seahorse and other OMS culture can play a role in management and conservation by supplementing and diversifying the fishing and collecting livelihoods in the developing nations that provide the majority of the global OMS.

  4. China-U.S. Trade Issues

    DTIC Science & Technology

    2009-06-23

    failure in some cases to ensure that its exported products meet U.S. health and safety standards. Further complicating the bilateral economic...resolution cases against China to the WTO; and continuing pressure on China to appreciate its currency. Others have warned against using...Implementation Issues ............................................................................................... 16 Pending U.S. Cases Against China

  5. China-U.S. Trade Issues

    DTIC Science & Technology

    2009-06-03

    failure in some cases to ensure that its exported products meet U.S. health and safety standards. Further complicating the bilateral economic...resolution cases against China to the WTO; and continuing pressure on China to appreciate its currency. Others have warned against using “protectionist...16 Pending U.S. Cases Against China

  6. The Global Expansion of Children's Television: A Case Study of the Adaptation of "Sesame Street" in Spain

    ERIC Educational Resources Information Center

    Moran, Kristin C.

    2006-01-01

    The landscape of children's programming is changing because of the increased exportation of children's television programs created in the USA. Networks have been aggressively marketing programs to an international audience through individual program sales and satellite network expansion. Some see problems as a result of the potential shift in…

  7. Effect of Foreign Presence on Domestic Performance: The Cases of Education in the US and Manufacturing Firms in Ethiopia

    ERIC Educational Resources Information Center

    Abegaz, Melaku

    2016-01-01

    This dissertation studies the effects of foreign presence on the performance of domestic institutions and economic agents. We identify three types of foreign presence: international students, inward foreign investment, and exporting activities. The first chapter investigates the impacts of international students on the graduation performance of…

  8. Carbon export in the naturally iron-fertilized Kerguelen area of the Southern Ocean based on the 234Th approach

    NASA Astrophysics Data System (ADS)

    Planchon, F.; Ballas, D.; Cavagna, A.-J.; Bowie, A. R.; Davies, D.; Trull, T.; Laurenceau-Cornec, E. C.; Van Der Merwe, P.; Dehairs, F.

    2015-06-01

    This study examined upper-ocean particulate organic carbon (POC) export using the 234Th approach as part of the second KErguelen Ocean and Plateau compared Study expedition (KEOPS2). Our aim was to characterize the spatial and the temporal variability of POC export during austral spring (October-November 2011) in the Fe-fertilized area of the Kerguelen Plateau region. POC export fluxes were estimated at high productivity sites over and downstream of the plateau and compared to a high-nutrient low-chlorophyll (HNLC) area upstream of the plateau in order to assess the impact of iron-induced productivity on the vertical export of carbon. Deficits in 234Th activities were observed at all stations in surface waters, indicating early scavenging by particles in austral spring. 234Th export was lowest at the reference station R-2 and highest in the recirculation region (E stations) where a pseudo-Lagrangian survey was conducted. In comparison 234Th export over the central plateau and north of the polar front (PF) was relatively limited throughout the survey. However, the 234Th results support that Fe fertilization increased particle export in all iron-fertilized waters. The impact was greatest in the recirculation feature (3-4 fold at 200 m depth, relative to the reference station), but more moderate over the central Kerguelen Plateau and in the northern plume of the Kerguelen bloom (~2-fold at 200 m depth). The C : Th ratio of large (>53 μm) potentially sinking particles collected via sequential filtration using in situ pumping (ISP) systems was used to convert the 234Th flux into a POC export flux. The C : Th ratios of sinking particles were highly variable (3.1 ± 0.1 to 10.5 ± 0.2 μmol dpm-1) with no clear site-related trend, despite the variety of ecosystem responses in the fertilized regions. C : Th ratios showed a decreasing trend between 100 and 200 m depth suggesting preferential carbon loss relative to 234Th possibly due to heterotrophic degradation and/or grazing activity. C : Th ratios of sinking particles sampled with drifting sediment traps in most cases showed very good agreement with ratios for particles collected via ISP deployments (>53 μm particles). Carbon export production varied between 3.5 ± 0.9 and 11.8 ± 1.3 mmol m-2 d-1 from the upper 100 m and between 1.8 ± 0.9 and 8.2 ± 0.9 mmol m-2 d-1 from the upper 200 m. The highest export production was found inside the PF meander with a range of 5.3 ± 1.0 to 11.8 ± 1.1 mmol m-2 d-1 over the 19-day survey period. The impact of Fe fertilization is highest inside the PF meander with 2.9-4.5-fold higher carbon flux at 200 m depth in comparison to the HNLC control station. The impact of Fe fertilization was significantly less over the central plateau (stations A3 and E-4W) and in the northern branch of the bloom (station F-L) with 1.6-2.0-fold higher carbon flux compared to the reference station R. Export efficiencies (ratio of export to primary production and ratio of export to new production) were particularly variable with relatively high values in the recirculation feature (6 to 27 %, respectively) and low values (1 to 5 %, respectively) over the central plateau (station A3) and north of the PF (station F-L), indicating spring biomass accumulation. Comparison with KEOPS1 results indicated that carbon export production is much lower during the onset of the bloom in austral spring than during the peak and declining phases in late summer.

  9. Opportunities and challenges for the export of U.S. value-added wood products to China

    Treesearch

    Scott Bowe; Matt Bumgardner; Terry Mace

    2008-01-01

    This report explores some of the opportunities for, and challenges associated with, exporting wood products to China. Five topics are examined: an overview of trends in forestry and forest products in China, export opportunities and challenges for U.S. primary wood producers (Study 1), export opportunities and challenges for U.S. secondary wood producers (Study 2),...

  10. JPRS Report, Soviet Union, Kommunist, No. 2, January 1989

    DTIC Science & Technology

    1989-04-20

    the entire increase in the production of refrig- erators was for export . However, in the case of a large number of goods deliveries to the trade...productivity would more than compensate for losses to the budget. A lowering of expenditures which had been financed out of income from the sale of wine ...implement the assignments of the 5-year plan, increased substan- tially. Combined with the further decline in exports , this resulted in a worsening

  11. 36 year trends in dissolved organic carbon export from Finnish rivers to the Baltic Sea.

    PubMed

    Räike, Antti; Kortelainen, Pirkko; Mattsson, Tuija; Thomas, David N

    2012-10-01

    Increasing dissolved organic carbon (DOC) concentrations in lakes, rivers and streams in northern mid latitudes have been widely reported during the last two decades, but relatively few studies have dealt with trends in DOC export. We studied the export of DOC from Finnish rivers to the Baltic Sea between 1975 and 2010, and estimated trends in DOC fluxes (both flow normalised and non-normalised). The study encompassed the whole Finnish Baltic Sea catchment area (301,000 km(2)) covering major land use patterns in the boreal zone. Finnish rivers exported annually over 900,000 t DOC to the Baltic Sea, and the mean area specific export was 3.5 t km(-2). The highest export (7.3t km(-2)) was measured in peat dominated catchments, whereas catchments rich in lakes had the lowest export (2.2 t km(-2)). Inter-annual variation in DOC export was high and controlled mainly by hydrology. There was no overall trend in the annual water flow, although winter flow increased in northern Finland over 36 years. Despite the numerous studies showing increases in DOC concentrations in streams and rivers in the northern hemisphere, we could not find any evidence of increases in DOC export to the northern Baltic Sea from Finnish catchments since 1975. Copyright © 2012 Elsevier B.V. All rights reserved.

  12. 27 CFR 19.607 - Marks on cases.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    .... Cases removed for export, transfer to customs bonded warehouses or customs manufacturing bonded warehouses, transfer to foreign-trade zones, or for use as supplies on certain vessels and aircraft, shall...; or (6) Labels or data describing the contents for commercial identification or accounting purposes...

  13. The economic impact of foot and mouth disease and its control in South-East Asia: a preliminary assessment with special reference to Thailand.

    PubMed

    Perry, B D; Kalpravidh, W; Coleman, P G; Horst, H S; McDermott, J J; Randolph, T F; Gleeson, L J

    1999-08-01

    A pilot study of the economic impact of foot and mouth disease (FMD) in the countries and region of South-East Asia is described. Previous economic impact assessments are reviewed and summarised and a synthesis of these contributions is constructed. A framework for the future economic impact of the disease is then developed, incorporating analyses at the sectoral (production system), national and regional levels. Data requirements for such studies are also identified. Integrated epidemiological and economic models for impact assessment were developed and applied to the case study country of Thailand. The models were used to evaluate the economic viability of FMD control programmes in the country. Scenarios evaluated include the effect of improving vaccination coverage and thus reducing productivity losses, and the effect of eventual eradication of the disease. The results indicate that economic returns to the high expenditures incurred in FMD control could be achieved in the short term if greater international trade in pork products was made possible and export prices higher than those in the domestic market could be attained. If FMD were to be eradicated from Thailand in 2010, the eradication would be economically viable, even without exports, with a predicted benefit-cost ratio of 3.73. With additional exports, the economic justification for control becomes much stronger with a benefit-cost ratio of up to 15:1 being achieved. If eradication is not achieved until 2020, returns remain positive without exports, but at a lower rate. The authors propose that the integrated epidemiological and economic models developed be applied to other countries of the region to gain a more accurate insight into the future benefits of FMD control and eradication in the region.

  14. ExportAid: database of RNA elements regulating nuclear RNA export in mammals.

    PubMed

    Giulietti, Matteo; Milantoni, Sara Armida; Armeni, Tatiana; Principato, Giovanni; Piva, Francesco

    2015-01-15

    Regulation of nuclear mRNA export or retention is carried out by RNA elements but the mechanism is not yet well understood. To understand the mRNA export process, it is important to collect all the involved RNA elements and their trans-acting factors. By hand-curated literature screening we collected, in ExportAid database, experimentally assessed data about RNA elements regulating nuclear export or retention of endogenous, heterologous or artificial RNAs in mammalian cells. This database could help to understand the RNA export language and to study the possible export efficiency alterations owing to mutations or polymorphisms. Currently, ExportAid stores 235 and 96 RNA elements, respectively, increasing and decreasing export efficiency, and 98 neutral assessed sequences. Freely accessible without registration at http://www.introni.it/ExportAid/ExportAid.html. Database and web interface are implemented in Perl, MySQL, Apache and JavaScript with all major browsers supported. © The Author 2014. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

  15. China’s Rise and Reconfiguration of Central Asia’s Geopolitics: A Case for U.S. Pivot to Eurasia

    DTIC Science & Technology

    2015-07-01

    comprehensive security” organization that is a China alternative to U.S.-pro- moted “collective security” alliance structures.57 This is not to dismiss...diversifica- tion of its gas and cotton exports-dependent economy. Kyrgyzstan is by far the least authoritarian state in Central Asia and, in the long run, may...Authorities have also failed to resuscitate its relatively isolated economy overly dependent on aluminum and cotton exports and ev- er-expanding drug flows

  16. The PRC Medium and Long-Term National Science and Technology Development Plan: A Manifesto to Steal

    DTIC Science & Technology

    2015-02-17

    rise in Chinese espionage cases, lax export laws in Hong Kong and recent changes to U.S. visa laws U.S. lawmakers must increase the focus on the...and embedded overseas Chinese scholars, importation of foreign technology through Hong Kong , joint ventures and export relationships with foreign...particularly hardware - to the PRC is through Hong Kong front companies. As example, just last year on 10 November 2014 a PRC national from Hong Kong

  17. Military Standard. Marking Technical Data Prepared by or for the Department of Defense

    DTIC Science & Technology

    1990-02-01

    Regulations f. ECCN - Export Commodity Control Number g. ED - Executive Order h. FOIA - Freedom of Information Act i. IEP - International Exchange...critical are explicitly covered in the CCL, ",, the Export Commodity Control Number ( ECCN ) reference is provided. In o~ner cases where the ECCN statement...controlling mechanism is in supplement three of the EAR. 3,7 MIL-STD-1806 APPENDIX B A listing such as " ECCN 1355A" means the technology is specifically

  18. Estimating the Cross-Shelf Export of Riverine Materials: Part 1. General Relationships From an Idealized Numerical Model

    NASA Astrophysics Data System (ADS)

    Izett, Jonathan G.; Fennel, Katja

    2018-02-01

    Rivers deliver large amounts of terrestrially derived materials (such as nutrients, sediments, and pollutants) to the coastal ocean, but a global quantification of the fate of this delivery is lacking. Nutrients can accumulate on shelves, potentially driving high levels of primary production with negative consequences like hypoxia, or be exported across the shelf to the open ocean where impacts are minimized. Global biogeochemical models cannot resolve the relatively small-scale processes governing river plume dynamics and cross-shelf export; instead, river inputs are often parameterized assuming an "all or nothing" approach. Recently, Sharples et al. (2017), https://doi.org/10.1002/2016GB005483 proposed the SP number—a dimensionless number relating the estimated size of a plume as a function of latitude to the local shelf width—as a simple estimator of cross-shelf export. We extend their work, which is solely based on theoretical and empirical scaling arguments, and address some of its limitations using a numerical model of an idealized river plume. In a large number of simulations, we test whether the SP number can accurately describe export in unforced cases and with tidal and wind forcings imposed. Our numerical experiments confirm that the SP number can be used to estimate export and enable refinement of the quantitative relationships proposed by Sharples et al. We show that, in general, external forcing has only a weak influence compared to latitude and derive empirical relationships from the results of the numerical experiments that can be used to estimate riverine freshwater export to the open ocean.

  19. Regulation of the Expression of Bacterial Multidrug Exporters by Two-Component Signal Transduction Systems.

    PubMed

    Nishino, Kunihiko

    2018-01-01

    Bacterial multidrug exporters confer resistance to a wide range of antibiotics, dyes, and biocides. Recent studies have shown that there are many multidrug exporters encoded in bacterial genome. For example, it was experimentally identified that E. coli has at least 20 multidrug exporters. Because many of these multidrug exporters have overlapping substrate spectra, it is intriguing that bacteria, with their economically organized genomes, harbor such large sets of multidrug exporter genes. The key to understanding how bacteria utilize these multiple exporters lies in the regulation of exporter expression. Bacteria have developed signaling systems for eliciting a variety of adaptive responses to their environments. These adaptive responses are often mediated by two-component regulatory systems. In this chapter, the method to identify response regulators that affect expression of multidrug exporters is described.

  20. 9 CFR 96.4 - Uncertified animal casings; disposition.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 1 2011-01-01 2011-01-01 false Uncertified animal casings; disposition. 96.4 Section 96.4 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE EXPORTATION AND IMPORTATION OF ANIMALS (INCLUDING POULTRY) AND ANIMAL PRODUCTS...

  1. 9 CFR 96.4 - Uncertified animal casings; disposition.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 9 Animals and Animal Products 1 2012-01-01 2012-01-01 false Uncertified animal casings; disposition. 96.4 Section 96.4 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE EXPORTATION AND IMPORTATION OF ANIMALS (INCLUDING POULTRY) AND ANIMAL PRODUCTS...

  2. 9 CFR 96.4 - Uncertified animal casings; disposition.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Uncertified animal casings; disposition. 96.4 Section 96.4 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE EXPORTATION AND IMPORTATION OF ANIMALS (INCLUDING POULTRY) AND ANIMAL PRODUCTS...

  3. 9 CFR 96.4 - Uncertified animal casings; disposition.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 9 Animals and Animal Products 1 2014-01-01 2014-01-01 false Uncertified animal casings; disposition. 96.4 Section 96.4 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE EXPORTATION AND IMPORTATION OF ANIMALS (INCLUDING POULTRY) AND ANIMAL PRODUCTS...

  4. 9 CFR 96.4 - Uncertified animal casings; disposition.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 9 Animals and Animal Products 1 2013-01-01 2013-01-01 false Uncertified animal casings; disposition. 96.4 Section 96.4 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE EXPORTATION AND IMPORTATION OF ANIMALS (INCLUDING POULTRY) AND ANIMAL PRODUCTS...

  5. The Export Trading Company Act of 1982 and the photovoltaics industry: An assessment

    NASA Technical Reports Server (NTRS)

    Enfield, S.; Laporta, C.

    1983-01-01

    The potential advantages of recent export promotion legislation for the U.S. photovoltaics industry were assessed. The provisions of the Export Trading Company Act of 1982 were reviewed and the export trade sector was surveyed to determine what impact the Act is haviang on export company activity. The photovoltaics industry was then studied to determine whether the Act offers particular advantages for promoting its product overseas.

  6. Corynebacterium glutamicum as a Host for Synthesis and Export of d-Amino Acids▿

    PubMed Central

    Stäbler, Norma; Oikawa, Tadao; Bott, Michael; Eggeling, Lothar

    2011-01-01

    A number of d-amino acids occur in nature, and there is growing interest in their function and metabolism, as well as in their production and use. Here we use the well-established l-amino-acid-producing bacterium Corynebacterium glutamicum to study whether d-amino acid synthesis is possible and whether mechanisms for the export of these amino acids exist. In contrast to Escherichia coli, C. glutamicum tolerates d-amino acids added extracellularly. Expression of argR (encoding the broad-substrate-specific racemase of Pseudomonas taetrolens) with its signal sequence deleted results in cytosolic localization of ArgR in C. glutamicum. The isolated enzyme has the highest activity with lysine (100%) but also exhibits activity with serine (2%). Upon overexpression of argR in an l-arginine, l-ornithine, or l-lysine producer, equimolar mixtures of the d- and l-enantiomers accumulated extracellularly. Unexpectedly, argR overexpression in an l-serine producer resulted in extracellular accumulation of a surplus of d-serine (81 mM d-serine and 37 mM l-serine) at intracellular concentrations of 125 mM d-serine plus 125 mM l-serine. This points to a nonlimiting ArgR activity for intracellular serine racemization and to the existence of a specific export carrier for d-serine. Export of d-lysine relies fully on the presence of lysE, encoding the exporter for l-lysine, which is apparently promiscuous with respect to the chirality of lysine. These data show that d-amino acids can also be produced with C. glutamicum and that in special cases, due to specific carriers, even a preferential extracellular accumulation of this enantiomer is possible. PMID:21257776

  7. Submersible UV-Vis Spectroscopy for Quantifying Streamwater Organic Carbon Dynamics: Implementation and Challenges before and after Forest Harvest in a Headwater Stream

    PubMed Central

    Jollymore, Ashlee; Johnson, Mark S.; Hawthorne, Iain

    2012-01-01

    Organic material, including total and dissolved organic carbon (DOC), is ubiquitous within aquatic ecosystems, playing a variety of important and diverse biogeochemical and ecological roles. Determining how land-use changes affect DOC concentrations and bioavailability within aquatic ecosystems is an important means of evaluating the effects on ecological productivity and biogeochemical cycling. This paper presents a methodology case study looking at the deployment of a submersible UV-Vis absorbance spectrophotometer (UV-Vis spectro∷lyzer model, s∷can, Vienna, Austria) to determine stream organic carbon dynamics within a headwater catchment located near Campbell River (British Columbia, Canada). Field-based absorbance measurements of DOC were made before and after forest harvest, highlighting the advantages of high temporal resolution compared to traditional grab sampling and laboratory measurements. Details of remote deployment are described. High-frequency DOC data is explored by resampling the 30 min time series with a range of resampling time intervals (from daily to weekly time steps). DOC export was calculated for three months from the post-harvest data and resampled time series, showing that sampling frequency has a profound effect on total DOC export. DOC exports derived from weekly measurements were found to underestimate export by as much as 30% compared to DOC export calculated from high-frequency data. Additionally, the importance of the ability to remotely monitor the system through a recently deployed wireless connection is emphasized by examining causes of prior data losses, and how such losses may be prevented through the ability to react when environmental or power disturbances cause system interruption and data loss. PMID:22666002

  8. Submersible UV-Vis spectroscopy for quantifying streamwater organic carbon dynamics: implementation and challenges before and after forest harvest in a headwater stream.

    PubMed

    Jollymore, Ashlee; Johnson, Mark S; Hawthorne, Iain

    2012-01-01

    Organic material, including total and dissolved organic carbon (DOC), is ubiquitous within aquatic ecosystems, playing a variety of important and diverse biogeochemical and ecological roles. Determining how land-use changes affect DOC concentrations and bioavailability within aquatic ecosystems is an important means of evaluating the effects on ecological productivity and biogeochemical cycling. This paper presents a methodology case study looking at the deployment of a submersible UV-Vis absorbance spectrophotometer (UV-Vis spectro::lyzer model, s::can, Vienna, Austria) to determine stream organic carbon dynamics within a headwater catchment located near Campbell River (British Columbia, Canada). Field-based absorbance measurements of DOC were made before and after forest harvest, highlighting the advantages of high temporal resolution compared to traditional grab sampling and laboratory measurements. Details of remote deployment are described. High-frequency DOC data is explored by resampling the 30 min time series with a range of resampling time intervals (from daily to weekly time steps). DOC export was calculated for three months from the post-harvest data and resampled time series, showing that sampling frequency has a profound effect on total DOC export. DOC exports derived from weekly measurements were found to underestimate export by as much as 30% compared to DOC export calculated from high-frequency data. Additionally, the importance of the ability to remotely monitor the system through a recently deployed wireless connection is emphasized by examining causes of prior data losses, and how such losses may be prevented through the ability to react when environmental or power disturbances cause system interruption and data loss.

  9. Architecture and nucleic acids recognition mechanism of the THO complex, an mRNP assembly factor

    PubMed Central

    Peña, Álvaro; Gewartowski, Kamil; Mroczek, Seweryn; Cuéllar, Jorge; Szykowska, Aleksandra; Prokop, Andrzej; Czarnocki-Cieciura, Mariusz; Piwowarski, Jan; Tous, Cristina; Aguilera, Andrés; Carrascosa, José L; Valpuesta, José María; Dziembowski, Andrzej

    2012-01-01

    The THO complex is a key factor in co-transcriptional formation of export-competent messenger ribonucleoprotein particles, yet its structure and mechanism of chromatin recruitment remain unknown. In yeast, this complex has been described as a heterotetramer (Tho2, Hpr1, Mft1, and Thp2) that interacts with Tex1 and mRNA export factors Sub2 and Yra1 to form the TRanscription EXport (TREX) complex. In this study, we purified yeast THO and found Tex1 to be part of its core. We determined the three-dimensional structures of five-subunit THO complex by electron microscopy and located the positions of Tex1, Hpr1, and Tho2 C-terminus using various labelling techniques. In the case of Tex1, a β-propeller protein, we have generated an atomic model which docks into the corresponding part of the THO complex envelope. Furthermore, we show that THO directly interacts with nucleic acids through the unfolded C-terminal region of Tho2, whose removal reduces THO recruitment to active chromatin leading to mRNA biogenesis defects. In summary, this study describes the THO architecture, the structural basis for its chromatin targeting, and highlights the importance of unfolded regions of eukaryotic proteins. PMID:22314234

  10. Double standards and the international trade of pesticides: the Brazilian case.

    PubMed

    Porto, Marcelo Firpo; Milanez, Bruno; Soares, Wagner Lopes; Meyer, Armando

    2010-01-01

    Despite bans on certain pesticides and their replacement by others considered less hazardous, the widespread use of these substances in agriculture continues to threaten the environment and the health of millions of people. This article discusses the current double standard in the international trade of pesticides and focuses on Brazil, one of the main users of pesticides in the world, analyzing the trends in foreign trade (imports and exports) of selected pesticides as a function of changes in legislation in the United States, the European Union, and Brazil from 1989 to 2006. We applied time line analysis to eight organochlorines already banned in Brazil and conducted a case-by-case qualitative and quantitative analysis of nine other pesticides. The results indicate the existence of double standards, as demonstrated by the continued exports to Brazil of some pesticides banned in the United States and Europe.

  11. Virtuous and vicious virtual water trade with application to Italy.

    PubMed

    Winter, Julia Anna; Allamano, Paola; Claps, Pierluigi

    2014-01-01

    The current trade of agricultural goods, with connections involving all continents, entails for global exchanges of "virtual" water, i.e. water used in the production process of alimentary products, but not contained within. Each trade link translates into a corresponding virtual water trade, allowing quantification of import and export fluxes of virtual water. The assessment of the virtual water import for a given nation, compared to the national consumption, could give an approximate idea of the country's reliance on external resources from the food and the water resources point of view. A descriptive approach to the understanding of a nation's degree of dependency from overseas food and water resources is first proposed, and indices of water trade virtuosity, as opposed to inefficiency, are devised. Such indices are based on the concepts of self-sufficiency and relative export, computed systematically on all products from the FAOSTAT database, taking Italy as the first case study. Analysis of time series of the self-sufficiency and relative export can demonstrate effects of market tendencies and influence water-related policies at the international level. The goal of this approach is highlighting incongruent terms in the virtual water balances by the viewpoint of single products. Specific products, which are here referred to as "swap products", are in fact identified as those that lead to inefficiencies in the virtual water balance due to their contemporaneously high import and export. The inefficiencies due to the exchanges of the same products between two nations are calculated in terms of virtual water volumes. Furthermore, the cases of swap products are investigated by computing two further indexes denoting the ratio of virtual water exchanged in the swap and the ratio of the economic values of the swapped products. The analysis of these figures can help examine the reasons behind the swap phenomenon in trade.

  12. Project analysis procedures for an OPEC country: case study of Qatar's Northwest Dome Gas Project

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Ali, A.B.; Khalifah, H.

    1986-01-01

    The discovery of oil in most OPEC countries in the 1940s changed the economies of these countries from a state of capital shortage and stagnation to a state of capital surplus and economic growth. This growth, however, is lopsided. Oil production and export dominate the gross domestic products (GDPs) of those economies. Concern arising during the 1970s about overdependence on crude oil export as the main source of national income has resulted in the initiation of various industrial development programs in OPEC states aiming to diversify their economies. This study was conducted with two primary objectives: (1) to identify andmore » understand the features of selected OPEC countries' development problems, strategies and plans, focusing on the role of oil and gas resources and opportunities for diversification, and (2) to suggest an appropriate development strategy, with project evaluation implications, for capital-abundant, labor-scarce OPEC countries in the Gulf region such as Qatar. This proposed approach is designed to evaluate the project from its contribution to the national income, people's welfare, the expansion of the economy's absorptive capacity, and relief of the economy's dependence on nonrenewable resources. The Northwest Dome Gas Project in Qatar was selected as an illustrative case study for this approach.« less

  13. 9 CFR 96.3 - Certificate for animal casings.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 9 Animals and Animal Products 1 2013-01-01 2013-01-01 false Certificate for animal casings. 96.3 Section 96.3 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE EXPORTATION AND IMPORTATION OF ANIMALS (INCLUDING POULTRY) AND ANIMAL PRODUCTS RESTRICTION OF...

  14. 9 CFR 96.3 - Certificate for animal casings.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 1 2011-01-01 2011-01-01 false Certificate for animal casings. 96.3 Section 96.3 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE EXPORTATION AND IMPORTATION OF ANIMALS (INCLUDING POULTRY) AND ANIMAL PRODUCTS RESTRICTION OF...

  15. 9 CFR 96.3 - Certificate for animal casings.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Certificate for animal casings. 96.3 Section 96.3 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE EXPORTATION AND IMPORTATION OF ANIMALS (INCLUDING POULTRY) AND ANIMAL PRODUCTS RESTRICTION OF...

  16. 9 CFR 96.3 - Certificate for animal casings.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 9 Animals and Animal Products 1 2012-01-01 2012-01-01 false Certificate for animal casings. 96.3 Section 96.3 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE EXPORTATION AND IMPORTATION OF ANIMALS (INCLUDING POULTRY) AND ANIMAL PRODUCTS RESTRICTION OF...

  17. 9 CFR 96.3 - Certificate for animal casings.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 9 Animals and Animal Products 1 2014-01-01 2014-01-01 false Certificate for animal casings. 96.3 Section 96.3 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE EXPORTATION AND IMPORTATION OF ANIMALS (INCLUDING POULTRY) AND ANIMAL PRODUCTS RESTRICTION OF...

  18. Challenges Faced by African International Students at a Metropolitan Research University: A Phenomenological Case Study

    ERIC Educational Resources Information Center

    Evivie, Loretta Gbemudu

    2009-01-01

    The number of international students coming to the United States has increased from 48,486 in 1959-1960 to 623,805 in the 2007-2008 academic years (Open Doors, 2008). These students contributed $15.5 billion to the United States economy, making education the nation's fifth largest service export (Open Doors, 2008). The literature has focused on…

  19. A Case Study of the NATO Identification System (NIS) Codevelopment Program

    DTIC Science & Technology

    1988-09-01

    the otherhand are unrelated to the military equipment being purchased. These offsets include foreign investment, technology transfer, and countertrade ...manufacturer and a foreign entity. 6. Countertrade - a transaction that specifies the exchange of selected goods and services for another of equivalent...arrangements. In fact, U.S. agencies are permitted to provide advisory and marketing intelligence services to U.S. exporters involved in countertrade

  20. Nutrient export from watersheds on Mt. Desert Island, maine, as a function of land use and fire history

    USGS Publications Warehouse

    Nielsen, M.G.; Kahl, J.S.

    2007-01-01

    A study of 13 small (less than 7.5 km2) watersheds on Mt. Desert Island, Maine, was conducted from January 1999 to September 2000 to determine nutrient export delivery to coastal waters around the island, and to determine whether a series of wildfires in 1947 have affected nutrient export in burned watersheds. Nutrient export (nitrate-nitrogen, total nitrogen, total phosphorus) was determined for each watershed during the study period, and was normalized by watershed area. The yield of nitrate-nitrogen (N) ranged from 10 to 140 kg/km2/year. Total N yield ranged from 42 to 250 kg/ km2/year. Total phosphorus (P) yield ranged from 1.4 to 7.9 kg/km2/year. Watersheds entirely within Acadia National Park (lacking human land-based nutrient sources) exported significantly less total N and total P than watersheds that were partly or entirely outside the park boundary. Nitrate-N export was not significantly different in these two groups of watersheds, perhaps because atmospheric deposition is a dominant source of nitrate in the study area. No relation was observed between burn history and nutrient export. Any effect of burn history may be masked by other landscape-level factors related to nutrient export. ?? Springer Science + Business Media B.V. 2007.

  1. 9 CFR 96.9 - Casings admitted on disinfection; sealing; transfer and disinfection.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 1 2011-01-01 2011-01-01 false Casings admitted on disinfection; sealing; transfer and disinfection. 96.9 Section 96.9 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE EXPORTATION AND IMPORTATION OF ANIMALS (INCLUDING POULTRY) AND...

  2. 9 CFR 96.9 - Casings admitted on disinfection; sealing; transfer and disinfection.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Casings admitted on disinfection; sealing; transfer and disinfection. 96.9 Section 96.9 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE EXPORTATION AND IMPORTATION OF ANIMALS (INCLUDING POULTRY) AND...

  3. Annual Energy Outlook

    EIA Publications

    2017-01-01

    The Annual Energy Outlook provides modeled projections of domestic energy markets through 2050, and includes cases with different assumptions of macroeconomic growth, world oil prices, technological progress, and energy policies. With strong domestic production and relatively flat demand, the United States becomes a net energy exporter over the projection period in most cases.

  4. AEO Table Browser

    EIA Publications

    An interactive data viewer that provides modeled projections of domestic energy markets through 2050, and includes cases with different assumptions of macroeconomic growth, world oil prices, technological progress, and energy policies. With strong domestic production and relatively flat demand, the United States becomes a net energy exporter over the projection period in most cases.

  5. 9 CFR 96.14 - Uncertified casings; disinfection with saturated brine solution.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Uncertified casings; disinfection with saturated brine solution. 96.14 Section 96.14 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE EXPORTATION AND IMPORTATION OF ANIMALS (INCLUDING POULTRY) AND ANIMAL...

  6. 9 CFR 96.14 - Uncertified casings; disinfection with saturated brine solution.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 1 2011-01-01 2011-01-01 false Uncertified casings; disinfection with saturated brine solution. 96.14 Section 96.14 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE EXPORTATION AND IMPORTATION OF ANIMALS (INCLUDING POULTRY) AND ANIMAL...

  7. 9 CFR 96.14 - Uncertified casings; disinfection with saturated brine solution.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 9 Animals and Animal Products 1 2013-01-01 2013-01-01 false Uncertified casings; disinfection with saturated brine solution. 96.14 Section 96.14 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE EXPORTATION AND IMPORTATION OF ANIMALS (INCLUDING POULTRY) AND ANIMAL...

  8. 9 CFR 96.14 - Uncertified casings; disinfection with saturated brine solution.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 9 Animals and Animal Products 1 2014-01-01 2014-01-01 false Uncertified casings; disinfection with saturated brine solution. 96.14 Section 96.14 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE EXPORTATION AND IMPORTATION OF ANIMALS (INCLUDING POULTRY) AND ANIMAL...

  9. 9 CFR 96.14 - Uncertified casings; disinfection with saturated brine solution.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 9 Animals and Animal Products 1 2012-01-01 2012-01-01 false Uncertified casings; disinfection with saturated brine solution. 96.14 Section 96.14 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE EXPORTATION AND IMPORTATION OF ANIMALS (INCLUDING POULTRY) AND ANIMAL...

  10. Export Market Orientation Behavior of Universities: The British Scenario

    ERIC Educational Resources Information Center

    Asaad, Yousra; Melewar, T. C.; Cohen, Geraldine

    2015-01-01

    This study seeks to extend our knowledge of export market orientation (EMO) in the context of British universities with regard to recruitment of international students. Export marketing remains an area of limited focus in the marketization of higher education literature. The study predominantly follows a quantitative research design using survey…

  11. Two Outer Membrane Proteins Contribute to Caulobacter crescentus Cellular Fitness by Preventing Intracellular S-Layer Protein Accumulation

    DOE PAGES

    Overton, K. Wesley; Park, Dan M.; Yung, Mimi C.; ...

    2016-09-23

    Surface layers, or S-layers, are two-dimensional protein arrays that form the outermost layer of many bacteria and archaea. They serve several functions, including physical protection of the cell from environmental threats. The high abundance of S-layer proteins necessitates a highly efficient export mechanism to transport the S-layer protein from the cytoplasm to the cell exterior.Caulobacter crescentusis unique in that it has two homologous, seemingly redundant outer membrane proteins, RsaF aand RsaF b, which together with other components form a type I protein translocation pathway for S-layer export. These proteins have homology toEscherichia coliTolC, the outer membrane channel of multidrug effluxmore » pumps. Here we provide evidence that, unlike TolC, RsaF aand RsaF bare not involved in either the maintenance of membrane stability or the active export of antimicrobial compounds. Rather, RsaF aand RsaF bare required to prevent intracellular accumulation and aggregation of the S-layer protein RsaA; deletion of RsaF aand RsaF bled to a general growth defect and lowered cellular fitness. Using Western blotting, transmission electron microscopy, and transcriptome sequencing (RNA-seq), we show that loss of both RsaF aand RsaF bled to accumulation of insoluble RsaA in the cytoplasm, which in turn caused upregulation of a number of genes involved in protein misfolding and degradation pathways. These findings provide new insight into the requirement for RsaF aand RsaF bin cellular fitness and tolerance to antimicrobial agents and further our understanding of the S-layer export mechanism on both the transcriptional and translational levels inC. crescentus. IMPORTANCEDecreased growth rate and reduced cell fitness are common side effects of protein production in overexpression systems. Inclusion bodies typically form inside the cell, largely due to a lack of sufficient export machinery to transport the overexpressed proteins to the extracellular environment. This phenomenon can conceivably also occur in natural systems. As one example of a system evolved to prevent intracellular protein accumulation, our study demonstrates thatCaulobacter crescentushas two homologous outer membrane transporter proteins that are involved in S-layer export. This is an interesting case study that demonstrates how bacteria can evolve redundancy to ensure adequate protein export functionality and maintain high cellular fitness. Moreover, we provide evidence that these two outer membrane proteins, although being the closestC. crescentushomologs to TolC inE. coli, do not process TolC functionality inC. crescentus.« less

  12. Two Outer Membrane Proteins Contribute to Caulobacter crescentus Cellular Fitness by Preventing Intracellular S-Layer Protein Accumulation

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Overton, K. Wesley; Park, Dan M.; Yung, Mimi C.

    ABSTRACT Surface layers, or S-layers, are two-dimensional protein arrays that form the outermost layer of many bacteria and archaea. They serve several functions, including physical protection of the cell from environmental threats. The high abundance of S-layer proteins necessitates a highly efficient export mechanism to transport the S-layer protein from the cytoplasm to the cell exterior.Caulobacter crescentusis unique in that it has two homologous, seemingly redundant outer membrane proteins, RsaF aand RsaF b, which together with other components form a type I protein translocation pathway for S-layer export. These proteins have homology toEscherichia coliTolC, the outer membrane channel of multidrugmore » efflux pumps. Here we provide evidence that, unlike TolC, RsaF aand RsaF bare not involved in either the maintenance of membrane stability or the active export of antimicrobial compounds. Rather, RsaF aand RsaF bare required to prevent intracellular accumulation and aggregation of the S-layer protein RsaA; deletion of RsaF aand RsaF bled to a general growth defect and lowered cellular fitness. Using Western blotting, transmission electron microscopy, and transcriptome sequencing (RNA-seq), we show that loss of both RsaF aand RsaF bled to accumulation of insoluble RsaA in the cytoplasm, which in turn caused upregulation of a number of genes involved in protein misfolding and degradation pathways. These findings provide new insight into the requirement for RsaF aand RsaF bin cellular fitness and tolerance to antimicrobial agents and further our understanding of the S-layer export mechanism on both the transcriptional and translational levels inC. crescentus. IMPORTANCEDecreased growth rate and reduced cell fitness are common side effects of protein production in overexpression systems. Inclusion bodies typically form inside the cell, largely due to a lack of sufficient export machinery to transport the overexpressed proteins to the extracellular environment. This phenomenon can conceivably also occur in natural systems. As one example of a system evolved to prevent intracellular protein accumulation, our study demonstrates thatCaulobacter crescentushas two homologous outer membrane transporter proteins that are involved in S-layer export. This is an interesting case study that demonstrates how bacteria can evolve redundancy to ensure adequate protein export functionality and maintain high cellular fitness. Moreover, we provide evidence that these two outer membrane proteins, although being the closestC. crescentushomologs to TolC inE. coli, do not process TolC functionality inC. crescentus.« less

  13. Two Outer Membrane Proteins Contribute to Caulobacter crescentus Cellular Fitness by Preventing Intracellular S-Layer Protein Accumulation

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Overton, K. Wesley; Park, Dan M.; Yung, Mimi C.

    Surface layers, or S-layers, are two-dimensional protein arrays that form the outermost layer of many bacteria and archaea. They serve several functions, including physical protection of the cell from environmental threats. The high abundance of S-layer proteins necessitates a highly efficient export mechanism to transport the S-layer protein from the cytoplasm to the cell exterior.Caulobacter crescentusis unique in that it has two homologous, seemingly redundant outer membrane proteins, RsaF aand RsaF b, which together with other components form a type I protein translocation pathway for S-layer export. These proteins have homology toEscherichia coliTolC, the outer membrane channel of multidrug effluxmore » pumps. Here we provide evidence that, unlike TolC, RsaF aand RsaF bare not involved in either the maintenance of membrane stability or the active export of antimicrobial compounds. Rather, RsaF aand RsaF bare required to prevent intracellular accumulation and aggregation of the S-layer protein RsaA; deletion of RsaF aand RsaF bled to a general growth defect and lowered cellular fitness. Using Western blotting, transmission electron microscopy, and transcriptome sequencing (RNA-seq), we show that loss of both RsaF aand RsaF bled to accumulation of insoluble RsaA in the cytoplasm, which in turn caused upregulation of a number of genes involved in protein misfolding and degradation pathways. These findings provide new insight into the requirement for RsaF aand RsaF bin cellular fitness and tolerance to antimicrobial agents and further our understanding of the S-layer export mechanism on both the transcriptional and translational levels inC. crescentus. IMPORTANCEDecreased growth rate and reduced cell fitness are common side effects of protein production in overexpression systems. Inclusion bodies typically form inside the cell, largely due to a lack of sufficient export machinery to transport the overexpressed proteins to the extracellular environment. This phenomenon can conceivably also occur in natural systems. As one example of a system evolved to prevent intracellular protein accumulation, our study demonstrates thatCaulobacter crescentushas two homologous outer membrane transporter proteins that are involved in S-layer export. This is an interesting case study that demonstrates how bacteria can evolve redundancy to ensure adequate protein export functionality and maintain high cellular fitness. Moreover, we provide evidence that these two outer membrane proteins, although being the closestC. crescentushomologs to TolC inE. coli, do not process TolC functionality inC. crescentus.« less

  14. The Empirical Study on the Labor Export of Three Gorges Reservoir Area in China

    NASA Astrophysics Data System (ADS)

    Hu, Bangyong

    There are many large surplus labor force in the three gorges reservoir area, export of labor services is one way to tackle the problem of employment of the surplus-labor and increase farmers income, export of labor is also a effective way to solve three rural issues. This paper analyzes the need for the development of service economy, study the problems of export of labor services, at last the author give some suggestion to develop labor economy.

  15. Regional water footprint evaluation in China: a case of Liaoning.

    PubMed

    Dong, Huijuan; Geng, Yong; Sarkis, Joseph; Fujita, Tsuyoshi; Okadera, Tomohiro; Xue, Bing

    2013-01-01

    Water-related problems are currently second only to energy issues as threats to human society. North China is a region that is facing severe water scarcity problems. In order to provide appropriate water mitigation policies a regional study is completed. Under this circumstance, Liaoning Province, a typical heavy industrial province in north China is chosen as a case study region. The input-output analysis method is employed in order to evaluate the water footprint both from production and consumption perspectives. The results show that the total water footprint of Liaoning in 2007 was 7.30 billionm(3), a 84.6% of internal water footprint and a 15.4% external water footprint. The water trade balance of Liaoning was 2.68 billionm(3), indicating that Liaoning was a net water export region, although water shortages are becoming a more serious concern. The "Agriculture" and "Food and beverage production" sectors are found to have the highest water footprint, water intensity, water exports, and water trade balance. Based upon Liaoning realities policy implications and suggestions are made, including industrial and trade structure adjustment, application of water efficient technology and management measures, and appropriate capacity-building efforts. The methodology and findings may be useful for investigation of water footprints throughout various regions of the world. Copyright © 2012 Elsevier B.V. All rights reserved.

  16. Analysis of Zinc-Exporters Expression in Prostate Cancer.

    PubMed

    Singh, Chandra K; Malas, Kareem M; Tydrick, Caitlin; Siddiqui, Imtiaz A; Iczkowski, Kenneth A; Ahmad, Nihal

    2016-11-11

    Maintaining optimal intracellular zinc (Zn) concentration is crucial for critical cellular functions. Depleted Zn has been associated with prostate cancer (PCa) progression. Solute carrier family 30 (SLC30A) proteins maintain cytoplasmic Zn balance by exporting Zn out to the extracellular space or by sequestering cytoplasmic Zn into intracellular compartments. In this study, we determined the involvement of Zn-exporters, SLC30A 1-10 in PCa, in the context of racial health disparity in human PCa samples obtained from European-American (EA) and African-American (AA) populations. We also analyzed the levels of Zn-exporters in a panel of PCa cells derived from EA and AA populations. We further explored the expression profile of Zn-exporters in PCa using Oncomine database. Zn-exporters were found to be differentially expressed at the mRNA level, with a significant upregulation of SLC30A1, SLC30A9 and SLC30A10, and downregulation of SLC30A5 and SLC30A6 in PCa, compared to benign prostate. Moreover, Ingenuity Pathway analysis revealed several interactions of Zn-exporters with certain tumor suppressor and promoter proteins known to be modulated in PCa. Our study provides an insight regarding Zn-exporters in PCa, which may open new avenues for future studies aimed at enhancing the levels of Zn by modulating Zn-transporters via pharmacological means.

  17. Analysis of Zinc-Exporters Expression in Prostate Cancer

    PubMed Central

    Singh, Chandra K.; Malas, Kareem M.; Tydrick, Caitlin; Siddiqui, Imtiaz A.; Iczkowski, Kenneth A.; Ahmad, Nihal

    2016-01-01

    Maintaining optimal intracellular zinc (Zn) concentration is crucial for critical cellular functions. Depleted Zn has been associated with prostate cancer (PCa) progression. Solute carrier family 30 (SLC30A) proteins maintain cytoplasmic Zn balance by exporting Zn out to the extracellular space or by sequestering cytoplasmic Zn into intracellular compartments. In this study, we determined the involvement of Zn-exporters, SLC30A 1–10 in PCa, in the context of racial health disparity in human PCa samples obtained from European-American (EA) and African-American (AA) populations. We also analyzed the levels of Zn-exporters in a panel of PCa cells derived from EA and AA populations. We further explored the expression profile of Zn-exporters in PCa using Oncomine database. Zn-exporters were found to be differentially expressed at the mRNA level, with a significant upregulation of SLC30A1, SLC30A9 and SLC30A10, and downregulation of SLC30A5 and SLC30A6 in PCa, compared to benign prostate. Moreover, Ingenuity Pathway analysis revealed several interactions of Zn-exporters with certain tumor suppressor and promoter proteins known to be modulated in PCa. Our study provides an insight regarding Zn-exporters in PCa, which may open new avenues for future studies aimed at enhancing the levels of Zn by modulating Zn-transporters via pharmacological means. PMID:27833104

  18. Quantifying the time lag between organic matter production and export in the surface ocean: Implications for estimates of export efficiency

    NASA Astrophysics Data System (ADS)

    Stange, P.; Bach, L. T.; Le Moigne, F. A. C.; Taucher, J.; Boxhammer, T.; Riebesell, U.

    2017-01-01

    The ocean's potential to export carbon to depth partly depends on the fraction of primary production (PP) sinking out of the euphotic zone (i.e., the e-ratio). Measurements of PP and export flux are often performed simultaneously in the field, although there is a temporal delay between those parameters. Thus, resulting e-ratio estimates often incorrectly assume an instantaneous downward export of PP to export flux. Evaluating results from four mesocosm studies, we find that peaks in organic matter sedimentation lag chlorophyll a peaks by 2 to 15 days. We discuss the implications of these time lags (TLs) for current e-ratio estimates and evaluate potential controls of TL. Our analysis reveals a strong correlation between TL and the duration of chlorophyll a buildup, indicating a dependency of TL on plankton food web dynamics. This study is one step further toward time-corrected e-ratio estimates.

  19. tRNA nuclear export in saccharomyces cerevisiae: in situ hybridization analysis.

    PubMed

    Sarkar, S; Hopper, A K

    1998-11-01

    To understand the factors specifically affecting tRNA nuclear export, we adapted in situ hybridization procedures to locate endogenous levels of individual tRNA families in wild-type and mutant yeast cells. Our studies of tRNAs encoded by genes lacking introns show that nucleoporin Nup116p affects both poly(A) RNA and tRNA export, whereas Nup159p affects only poly(A) RNA export. Los1p is similar to exportin-t, which facilitates vertebrate tRNA export. A los1 deletion mutation affects tRNA but not poly(A) RNA export. The data support the notion that Los1p and exportin-t are functional homologues. Because LOS1 is nonessential, tRNA export in vertebrate and yeast cells likely involves factors in addition to exportin-t. Mutation of RNA1, which encodes RanGAP, causes nuclear accumulation of tRNAs and poly(A) RNA. Many yeast mutants, including those with the rna1-1 mutation, affect both pre-tRNA splicing and RNA export. Our studies of the location of intron-containing pre-tRNAs in the rna1-1 mutant rule out the possibility that this results from tRNA export occurring before splicing. Our results also argue against inappropriate subnuclear compartmentalization causing defects in pre-tRNA splicing. Rather, the data support "feedback" of nucleus/cytosol exchange to the pre-tRNA splicing machinery.

  20. tRNA Nuclear Export in Saccharomyces cerevisiae: In Situ Hybridization Analysis

    PubMed Central

    Sarkar, Srimonti; Hopper, Anita K.

    1998-01-01

    To understand the factors specifically affecting tRNA nuclear export, we adapted in situ hybridization procedures to locate endogenous levels of individual tRNA families in wild-type and mutant yeast cells. Our studies of tRNAs encoded by genes lacking introns show that nucleoporin Nup116p affects both poly(A) RNA and tRNA export, whereas Nup159p affects only poly(A) RNA export. Los1p is similar to exportin-t, which facilitates vertebrate tRNA export. A los1 deletion mutation affects tRNA but not poly(A) RNA export. The data support the notion that Los1p and exportin-t are functional homologues. Because LOS1 is nonessential, tRNA export in vertebrate and yeast cells likely involves factors in addition to exportin-t. Mutation of RNA1, which encodes RanGAP, causes nuclear accumulation of tRNAs and poly(A) RNA. Many yeast mutants, including those with the rna1-1 mutation, affect both pre-tRNA splicing and RNA export. Our studies of the location of intron-containing pre-tRNAs in the rna1-1 mutant rule out the possibility that this results from tRNA export occurring before splicing. Our results also argue against inappropriate subnuclear compartmentalization causing defects in pre-tRNA splicing. Rather, the data support “feedback” of nucleus/cytosol exchange to the pre-tRNA splicing machinery. PMID:9802895

  1. 75 FR 13330 - Bureau of Political-Military Affairs; Statutory Debarment Under the Arms Export Control Act and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-19

    .... District Court, Southern District of Texas, Case 7:08CR01610-001. (24) Reynol Garcia, June 12, 2009, U.S... Quilantan-Garcia, December 9, 2009, U.S. District Court, Southern District of Texas, Case 7:09CR00874-001... Texas, Case 7:09CR01019- 001. (28) Roberto Carlos Garcia-Salazar, January 31, 2009, U.S. District Court...

  2. Worldwide Threat Assessment of the U.S. Intelligence Community

    DTIC Science & Technology

    2011-03-10

    to political stability in all cases . African elections are likely to continue in many cases to heighten tensions and intensify conflict. Critical...priorities, and bureaucratic resistance. The Mexican Congress recently passed a law to toughen penalties in kidnapping cases , and is considering...situation is dire. Major sources of foreign revenue such as nickel exports and tourism have decreased. Moreover, a decline in foreign currency reserves

  3. 12 CFR 411.500 - Secretary of Defense.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 4 2010-01-01 2010-01-01 false Secretary of Defense. 411.500 Section 411.500 Banks and Banking EXPORT-IMPORT BANK OF THE UNITED STATES NEW RESTRICTIONS ON LOBBYING Exemptions § 411.500 Secretary of Defense. (a) The Secretary of Defense may exempt, on a case-by-case basis, a covered...

  4. From Ivory Towers to International Business: Are Universities Export Ready in Their Recruitment of International Students?

    ERIC Educational Resources Information Center

    Naidoo, Vik

    2010-01-01

    The main hypothesis examined in this study is that the success of export recruitment strategies of universities is partly determined by their export readiness, defined as a function of market orientation. This article seeks to fulfil both a research and a practitioner gap in the export of education field. There currently exists a lack of research…

  5. Revealing the hidden health costs embodied in Chinese exports.

    PubMed

    Jiang, Xujia; Zhang, Qiang; Zhao, Hongyan; Geng, Guannan; Peng, Liqun; Guan, Dabo; Kan, Haidong; Huo, Hong; Lin, Jintai; Brauer, Michael; Martin, Randall V; He, Kebin

    2015-04-07

    China emits a considerable amount of air pollutants when producing goods for export. Previous efforts have emphasized the magnitude of export-related emissions; however, their health consequences on the Chinese population have not been quantified. Here, we present an interdisciplinary study to estimate the health impact of export-related air pollution. The results show that export-related emissions elevated the annual mean population weighted PM2.5 by 8.3 μg/m(3) (15% of the total) in 2007, causing 157,000 deaths and accounting for 12% of the total mortality attributable to PM2.5-related air pollution. Compared to the eastern coastal provinces, the inner regions experience much larger export-related health losses relative to their economic production gains, owing to huge inter-regional disparities in export structures and technology levels. A shift away from emission-intensive production structure and export patterns, especially in inner regions, could significantly help improve national exports while alleviating the inter-regional cost-benefit inequality. Our results provide the first quantification of health consequences from air pollution related to Chinese exports. The proposed policy recommendations, based on health burden, economic production gains, and emission analysis, would be helpful to develop more sustainable and effective national and regional export strategies.

  6. Increased nitrogen export from eastern North America to the Atlantic Ocean due to climatic and anthropogenic changes during 1901-2008

    NASA Astrophysics Data System (ADS)

    Yang, Qichun; Tian, Hanqin; Friedrichs, Marjorie A. M.; Hopkinson, Charles S.; Lu, Chaoqun; Najjar, Raymond G.

    2015-06-01

    We used a process-based land model, Dynamic Land Ecosystem Model 2.0, to examine how climatic and anthropogenic changes affected riverine fluxes of ammonium (NH4+), nitrate (NO3-), dissolved organic nitrogen (DON), and particulate organic nitrogen (PON) from eastern North America, especially the drainage areas of the Gulf of Maine (GOM), Mid-Atlantic Bight (MAB), and South Atlantic Bight (SAB) during 1901-2008. Model simulations indicated that annual fluxes of NH4+, NO3-, DON, and PON from the study area during 1980-2008 were 0.019 ± 0.003 (mean ± 1 standard deviation) Tg N yr-1, 0.18 ± 0.035 Tg N yr-1, 0.10 ± 0.016 Tg N yr-1, and 0.043 ± 0.008 Tg N yr-1, respectively. NH4+, NO3-, and DON exports increased while PON export decreased from 1901 to 2008. Nitrogen export demonstrated substantial spatial variability across the study area. Increased NH4+ export mainly occurred around major cities in the MAB. NO3- export increased in most parts of the MAB but decreased in parts of the GOM. Enhanced DON export was mainly distributed in the GOM and the SAB. PON export increased in coastal areas of the SAB and northern parts of the GOM but decreased in the Piedmont areas and the eastern parts of the MAB. Climate was the primary reason for interannual variability in nitrogen export; fertilizer use and nitrogen deposition tended to enhance the export of all nitrogen species; livestock farming and sewage discharge were also responsible for the increases in NH4+ and NO3- fluxes; and land cover change (especially reforestation of former agricultural land) reduced the export of the four nitrogen species.

  7. Wheat forecast economics effect study. [value of improved information on crop inventories, production, imports and exports

    NASA Technical Reports Server (NTRS)

    Mehra, R. K.; Rouhani, R.; Jones, S.; Schick, I.

    1980-01-01

    A model to assess the value of improved information regarding the inventories, productions, exports, and imports of crop on a worldwide basis is discussed. A previously proposed model is interpreted in a stochastic control setting and the underlying assumptions of the model are revealed. In solving the stochastic optimization problem, the Markov programming approach is much more powerful and exact as compared to the dynamic programming-simulation approach of the original model. The convergence of a dual variable Markov programming algorithm is shown to be fast and efficient. A computer program for the general model of multicountry-multiperiod is developed. As an example, the case of one country-two periods is treated and the results are presented in detail. A comparison with the original model results reveals certain interesting aspects of the algorithms and the dependence of the value of information on the incremental cost function.

  8. A non-canonical mechanism for Crm1-export cargo complex assembly.

    PubMed

    Fischer, Ute; Schäuble, Nico; Schütz, Sabina; Altvater, Martin; Chang, Yiming; Faza, Marius Boulos; Panse, Vikram Govind

    2015-04-21

    The transport receptor Crm1 mediates the export of diverse cargos containing leucine-rich nuclear export signals (NESs) through complex formation with RanGTP. To ensure efficient cargo release in the cytoplasm, NESs have evolved to display low affinity for Crm1. However, mechanisms that overcome low affinity to assemble Crm1-export complexes in the nucleus remain poorly understood. In this study, we reveal a new type of RanGTP-binding protein, Slx9, which facilitates Crm1 recruitment to the 40S pre-ribosome-associated NES-containing adaptor Rio2. In vitro, Slx9 binds Rio2 and RanGTP, forming a complex. This complex directly loads Crm1, unveiling a non-canonical stepwise mechanism to assemble a Crm1-export complex. A mutation in Slx9 that impairs Crm1-export complex assembly inhibits 40S pre-ribosome export. Thus, Slx9 functions as a scaffold to optimally present RanGTP and the NES to Crm1, therefore, triggering 40S pre-ribosome export. This mechanism could represent one solution to the paradox of weak binding events underlying rapid Crm1-mediated export.

  9. Influence of export control policy on the competitiveness of machine tool producing organizations

    NASA Astrophysics Data System (ADS)

    Ahrstrom, Jeffrey D.

    The possible influence of export control policies on producers of export controlled machine tools is examined in this quantitative study. International market competitiveness theories hold that market controlling policies such as export control regulations may influence an organization's ability to compete (Burris, 2010). Differences in domestic application of export control policy on machine tool exports may impose throttling effects on the competitiveness of participating firms (Freedenberg, 2010). Commodity shipments from Japan, Germany, and the United States to the Russian market will be examined using descriptive statistics; gravity modeling of these specific markets provides a foundation for comparison to actual shipment data; and industry participant responses to a user developed survey will provide additional data for analysis using a Kruskal-Wallis one-way analysis of variance. There is scarce academic research data on the topic of export control effects within the machine tool industry. Research results may be of interest to industry leadership in market participation decisions, advocacy arguments, and strategic planning. Industry advocates and export policy decision makers could find data of interest in supporting positions for or against modifications of export control policies.

  10. Oil prices, fiscal policy, and economic growth in oil-exporting countries

    NASA Astrophysics Data System (ADS)

    El-Anshasy, Amany A.

    This dissertation argues that in oil-exporting countries fiscal policy could play an important role in transmitting the oil shocks to the economy and that the indirect effects of the changes in oil prices via the fiscal channel could be quite significant. The study comprises three distinct, yet related, essays. In the first essay, I try to study the fiscal policy response to the changes in oil prices and to their growing volatility. In a dynamic general equilibrium framework, a fiscal policy reaction function is derived and is empirically tested for a panel of 15 oil-exporters covering the period 1970--2000. After the link between oil price shocks and fiscal policy is established, the second essay tries to investigate the impact of the highly volatile oil prices on economic growth for the same sample, controlling for the fiscal channel. In both essays the study employs recent dynamic panel-data estimation techniques: System GMM. This approach has the potential advantages of minimizing the bias resulting from estimating dynamic panel models, exploiting the time series properties of the data, controlling for the unobserved country-specific effects, and correcting for any simultaneity bias. In the third essay, I focus on the case of Venezuela for the period 1950--2001. The recent developments in the cointegrating vector autoregression, CVAR technique is applied to provide a suitable framework for analyzing the short-run dynamics and the long-run relationships among oil prices, government revenues, government consumption, investment, and output.

  11. Assessment of Export Efficiency Equations in the Southern Ocean Applied to Satellite-Based Net Primary Production

    NASA Astrophysics Data System (ADS)

    Arteaga, Lionel; Haëntjens, Nils; Boss, Emmanuel; Johnson, Kenneth S.; Sarmiento, Jorge L.

    2018-04-01

    Carbon export efficiency (e-ratio) is defined as the fraction of organic carbon fixed through net primary production (NPP) that is exported out of the surface productive layer of the ocean. Recent observations for the Southern Ocean suggest a negative e-ratio versus NPP relationship, and a reduced dependency of export efficiency on temperature, different than in the global domain. In this study, we complement information from a passive satellite sensor with novel space-based lidar observations of ocean particulate backscattering to infer NPP over the entire annual cycle, and estimate Southern Ocean export rates from five different empirical models of export efficiency. Inferred Southern Ocean NPP falls within the range of previous studies, with a mean estimate of 15.8 (± 3.9) Pg C yr-1 for the region south of 30°S during the 2005-2016 period. We find that an export efficiency model that accounts for silica(Si)-ballasting, which is constrained by observations with a negative e-ratio versus NPP relationship, shows the best agreement with in situ-based estimates of annual net community production (annual export of 2.7 ± 0.6 Pg C yr-1 south of 30°S). By contrast, models based on the analysis of global observations with a positive e-ratio versus NPP relationship predict annually integrated export rates that are ˜ 33% higher than the Si-dependent model. Our results suggest that accounting for Si-induced ballasting is important for the estimation of carbon export in the Southern Ocean.

  12. Optimizing coffee cultivation and its impact on economic growth and export earnings of the producing countries: The case of Saudi Arabia.

    PubMed

    Al-Abdulkader, Ahmed M; Al-Namazi, Ali A; AlTurki, Turki A; Al-Khuraish, Muteb M; Al-Dakhil, Abdullah I

    2018-05-01

    Coffee is one of the historical socioeconomic crops. It has received an increasing attention at the global level, due to its positive interlinkage with the economic growth and on the gross domestic product for most of the producing countries, particularly, developing and least developed countries. Saudi Arabia is one of the coffee producing countries that has a relative comparative advantage of coffee cultivation. Yet, coffee cultivation has not received as much attention in Saudi Arabia as that of producing countries around the world. This study aims to assess the current state of coffee cultivation in Saudi Arabia and to investigate the potential to optimize coffee cultivation in Saudi Arabia that maximizes the net national economic return and export earnings, given limitation of cultivated areas, local market activities, and international trade activities. The study statistically analyzed primary data collected from around (65) coffee farms and traders in the study regions at the south and southwest Saudi Arabia, and optimized coffee cultivation in Saudi Arabia using LINGO optimization software. Empirical results of the study revealed the great potential of Saudi Arabia to expand coffee cultivation at south and southwest regions to meet the escalating local demand and to increase its share at the world market up to 2%. Optimization of coffee cultivation in Saudi Arabia showed a high potential to meet the local demand for coffee by producing 80.07 thousand tons grown over 2861.78 hectares and to generate a net return equivalent to $395.72 million a year, which is equivalent to $138.28 thousand per hectare and $4.94 thousand per ton of coffee. Optimizing coffee cultivation will play a substantial role to increase market share of Saudi Arabia to about 1-2% of the world market by increasing its export volume, respectively, to about 69.66 and 112.56 thousand tons, the national net economic return by about $395.86 and $395.95 million a year, and the export earnings of coffee by about $219.43-354.57 million a year, which in turns, will serve the national strategic trend to diversify the economic base and lower the dependency of incomes generated from oil exportation.

  13. 234Th-based export fluxes during a natural iron fertilization experiment in the Southern Ocean (KEOPS)

    NASA Astrophysics Data System (ADS)

    Savoye, N.; Trull, T. W.; Jacquet, S. H. M.; Navez, J.; Dehairs, F.

    2008-03-01

    Five iron-fertilization experiments in the Southern Ocean have clearly demonstrated that adding iron increases primary production, but the implications for carbon export to the ocean interior have been less clear. This reflects both observational limitations of short-term experiments and their uncertain relevance to quantifying ecosystem level processes that are likely to be structured differently under conditions of punctual versus persistent stimulation. To avoid these biases, KEOPS (KErguelen Ocean and Plateau compared Study) investigated the naturally iron-fertilized Kerguelen Plateau region in the Indian Sector of the Southern Ocean that exhibits an annual phytoplankton bloom. Here, we report particulate organic carbon (POC) and nitrogen export from this system based on the 234Th approach. Results indicate that the export fluxes were variable both on and off the Kerguelen Plateau (9.0-38.4 mmol C m -2 d -1 and 1.6-4.8 mmol N m -2 d -1) and were in the range of values reported for natural Southern Ocean ecosystems. Export fluxes were compared at two reference stations, one above and one outside the Plateau. The station above the plateau was characterized by higher iron supply and export fluxes compared to the station outside the plateau. The difference in the export flux between these two reference stations defines the export excess induced by iron fertilization. It was 10.8±4.9 mmol C m -2 d -1 and 0.9±0.7 mmol N m -2 d -1 at 100 m, and 14.2±7.7 mmol C m -2 d -1 and 2.0±1.3 mmol N m -2 d -1 at 200 m. This POC export excess was similar to those found during other studies of artificial (SOFeX) and natural (CROZEX) iron fertilization in the Southern Ocean. The examination of the export efficiency (defined as the ratio of export to primary production) revealed significant variability over the plateau related to the temporal decoupling of production and export during the demise of the bloom. On average, the export efficiency was lower over the plateau than in surrounding waters, suggesting that increased iron supply may increase total export but lower export efficiency. Our findings are very important for evaluating present and past carbon cycling in the Southern and global oceans and for assessing predictive scenarios of carbon cycling and budget.

  14. Factors controlling the long-term temporal and spatial patterns of nitrate-nitrogen export in a dairy farming watershed.

    PubMed

    Jiang, Rui; Wang, Chun-ying; Hatano, Ryusuke; Kuramochi, Kanta; Hayakawa, Atsushi; Woli, Krishna P

    2015-04-01

    It is difficult to investigate the factors that control the riverine nitrate-nitrogen (NO3--N) export in a watershed which gains or losses groundwater. To control the NO3--N contamination in these watersheds, it is necessary to investigate the factors that are related to the export of NO3--N that is only produced by the watershed itself. This study was conducted in the Shibetsu watershed located in eastern Hokkaido, Japan, which gains external groundwater contribution (EXT) and 34% of the annual NO3--N loading occurs through EXT. The riverine NO3--N exports from 1980 to 2009 were simulated by the SWAT model, and the factors controlling the temporal and spatial patterns of NO3--N exports were investigated without considering the EXT. The results show that hydrological events control NO3--N export at the seasonal scale, while the hydrological and biogeochemical processes are likely to control NO3--N export at the annual scale. There was an integrated effect among the land use, topography, and soil type related to denitrification process, that regulated the spatial patterns of NO3--N export. The spatial distribution of NO3--N export from hydrologic response units (HRUs) identified the agricultural areas with surplus N that are vulnerable to nitrate contamination. A new standard for the N fertilizer application rate including manure application should be given to control riverine NO3--N export. This study demonstrates that applying the SWAT model is an appropriate method to determine the temporal and spatial patterns of NO3--N export from the watershed which includes EXT and to identify the crucial pollution areas within a watershed in which the management practices can be improved to more effectively control NO3--N export to water bodies.

  15. Virtual water trade and time scales for loss of water sustainability: a comparative regional analysis.

    PubMed

    Goswami, Prashant; Nishad, Shiv Narayan

    2015-03-20

    Assessment and policy design for sustainability in primary resources like arable land and water need to adopt long-term perspective; even small but persistent effects like net export of water may influence sustainability through irreversible losses. With growing consumption, this virtual water trade has become an important element in the water sustainability of a nation. We estimate and contrast the virtual (embedded) water trades of two populous nations, India and China, to present certain quantitative measures and time scales. Estimates show that export of embedded water alone can lead to loss of water sustainability. With the current rate of net export of water (embedded) in the end products, India is poised to lose its entire available water in less than 1000 years; much shorter time scales are implied in terms of water for production. The two cases contrast and exemplify sustainable and non-sustainable virtual water trade in long term perspective.

  16. Virtual water trade and time scales for loss of water sustainability: A comparative regional analysis

    NASA Astrophysics Data System (ADS)

    Goswami, Prashant; Nishad, Shiv Narayan

    2015-03-01

    Assessment and policy design for sustainability in primary resources like arable land and water need to adopt long-term perspective; even small but persistent effects like net export of water may influence sustainability through irreversible losses. With growing consumption, this virtual water trade has become an important element in the water sustainability of a nation. We estimate and contrast the virtual (embedded) water trades of two populous nations, India and China, to present certain quantitative measures and time scales. Estimates show that export of embedded water alone can lead to loss of water sustainability. With the current rate of net export of water (embedded) in the end products, India is poised to lose its entire available water in less than 1000 years; much shorter time scales are implied in terms of water for production. The two cases contrast and exemplify sustainable and non-sustainable virtual water trade in long term perspective.

  17. Climate change and dissolved organic carbon export to the Gulf of Maine

    USGS Publications Warehouse

    Huntington, Thomas G.; Balch, William M.; Aiken, George R.; Sheffield, Justin; Luo, Lifeng; Roesler, Collin S.; Camill, Philip

    2016-01-01

    Ongoing climate change is affecting the concentration, export (flux), and timing of dissolved organic carbon (DOC) exported to the Gulf of Maine (GoM) through changes in hydrologic regime. DOC export was calculated for water years 1950 through 2013 for 20 rivers and for water years 1930 through 2013 for 14 rivers draining to the GoM. DOC export was also estimated for the 21st century based on climate and hydrologic modeling in a previously published study. DOC export was calculated by using the regression model LOADEST to fit seasonally adjusted concentration discharge (C-Q) relations. Our results are an analysis of the sensitivity of DOC export to changes in hydrologic conditions over time since land cover and vegetation were held constant over time. Despite large interannual variability, all rivers had increasing DOC export during winter and these trends were significant (p < 0.05) in 10 out of 20 rivers for 1950 to 2013 and in 13 out of 14 rivers for 1930 to 2013. All rivers also had increasing annual export of DOC although fewer trends were statistically significant than for winter export. Projections for DOC export during the 21st century were variable depending on the climate model and greenhouse gas emission scenario that affected future river discharge through effects on precipitation and evapotranspiration. The most consistent result was a significant increase in DOC export in winter in all model-by-emission scenarios. DOC export was projected to decrease during the summer in all model-by-emission scenarios, with statistically significant decreases in half of the scenarios.

  18. Aquarium Trade Supply-Chain Losses of Marine Invertebrates Originating from Papua New Guinea.

    PubMed

    Militz, Thane A; Kinch, Jeff; Southgate, Paul C

    2018-04-01

    A major difficulty in managing live organism wildlife trade is often the reliance on trade data to monitor exploitation of wild populations. Harvested organisms that die or are discarded before a point of sale are regularly not reported. For the global marine aquarium trade, identifying supply-chain losses is necessary to more accurately assess exploitation from trade data. We examined quality control rejections and mortality of marine invertebrates (Asteroidea, Gastropoda, Malacostraca, Ophiuroidea) moving through the Papua New Guinea marine aquarium supply-chain, from fisher to importer. Utilizing catch invoices and exporter mortality records we determined that, over a 160 day period, 38.6% of the total invertebrate catch (n = 13,299 individuals) was lost before export. Supply-chain losses were divided among invertebrates rejected in the quality control process (11.5%) and mortality of the accepted catch in transit to, and during holding at, an export facility (30.6%). A further 0.3% died during international transit to importers. We quantified supply-chain losses for the ten most fished species which accounted for 96.4% of the catch. Quality control rejections (n = 1533) were primarily explained by rejections of oversized invertebrates (83.2% of rejections). We suggest that enforceable size limits on species prone to size-based rejections and elimination of village-based holding of invertebrates would reduce losses along the Papua New Guinea supply-chain. This case study underscores that low mortality during international transit may mask large losses along supply-chains prior to export and exemplifies the limitations of trade data to accurately monitor exploitation.

  19. Aquarium Trade Supply-Chain Losses of Marine Invertebrates Originating from Papua New Guinea

    NASA Astrophysics Data System (ADS)

    Militz, Thane A.; Kinch, Jeff; Southgate, Paul C.

    2018-04-01

    A major difficulty in managing live organism wildlife trade is often the reliance on trade data to monitor exploitation of wild populations. Harvested organisms that die or are discarded before a point of sale are regularly not reported. For the global marine aquarium trade, identifying supply-chain losses is necessary to more accurately assess exploitation from trade data. We examined quality control rejections and mortality of marine invertebrates (Asteroidea, Gastropoda, Malacostraca, Ophiuroidea) moving through the Papua New Guinea marine aquarium supply-chain, from fisher to importer. Utilizing catch invoices and exporter mortality records we determined that, over a 160 day period, 38.6% of the total invertebrate catch ( n = 13,299 individuals) was lost before export. Supply-chain losses were divided among invertebrates rejected in the quality control process (11.5%) and mortality of the accepted catch in transit to, and during holding at, an export facility (30.6%). A further 0.3% died during international transit to importers. We quantified supply-chain losses for the ten most fished species which accounted for 96.4% of the catch. Quality control rejections ( n = 1533) were primarily explained by rejections of oversized invertebrates (83.2% of rejections). We suggest that enforceable size limits on species prone to size-based rejections and elimination of village-based holding of invertebrates would reduce losses along the Papua New Guinea supply-chain. This case study underscores that low mortality during international transit may mask large losses along supply-chains prior to export and exemplifies the limitations of trade data to accurately monitor exploitation.

  20. The aspartyl protease TgASP5 mediates the export of the Toxoplasma GRA16 and GRA24 effectors into host cells.

    PubMed

    Curt-Varesano, Aurélie; Braun, Laurence; Ranquet, Caroline; Hakimi, Mohamed-Ali; Bougdour, Alexandre

    2016-02-01

    Toxoplasma gondii and Plasmodium species are obligatory intracellular parasites that export proteins into the infected cells in order to interfere with host-signalling pathways, acquire nutrients or evade host defense mechanisms. With regard to export mechanism, a wealth of information in Plasmodium spp. is available, while the mechanisms operating in T. gondii remain uncertain. The recent discovery of exported proteins in T. gondii, mainly represented by dense granule resident proteins, might explain this discrepancy and offers a unique opportunity to study the export mechanism in T. gondii. Here, we report that GRA16 export is mediated by two protein elements present in its N-terminal region. Because the first element contains a putative Plasmodium export element linear motif (RRLAE), we hypothesized that GRA16 export depended on a maturation process involving protein cleavage. Using both N- and C-terminal epitope tags, we provide evidence for protein proteolysis occurring in the N-terminus of GRA16. We show that TgASP5, the T. gondii homolog of Plasmodium plasmepsin V, is essential for GRA16 export and is directly responsible for its maturation in a Plasmodium export element-dependent manner. Interestingly, TgASP5 is also involved in GRA24 export, although the GRA24 maturation mechanism is TgASP5-independent. Our data reveal different modus operandi for protein export, in which TgASP5 should play multiple functions. © 2015 John Wiley & Sons Ltd.

  1. A calreticulin-dependent nuclear export signal is involved in the regulation of liver receptor homologue-1 protein folding.

    PubMed

    Yang, Feng-Ming; Feng, Shan-Jung; Lai, Tsai-Chun; Hu, Meng-Chun

    2015-10-15

    As an orphan member of the nuclear receptor family, liver receptor homologue-1 (LRH-1) controls a tremendous range of transcriptional programmes that are essential for metabolism and hormone synthesis. Our previous studies have shown that nuclear localization of the LRH-1 protein is mediated by two nuclear localization signals (NLSs) that are karyopherin/importin-dependent. It is unclear whether LRH-1 can be actively exported from the nucleus to the cytoplasm. In the present study, we describe a nuclear export domain containing two leucine-rich motifs [named nuclear export signal (NES)1 and NES2] within the ligand-binding domain (LBD). Mutation of leucine residues in NES1 or NES2 abolished nuclear export, indicating that both NES1 and NES2 motifs are essential for full nuclear export activity. This NES-mediated nuclear export was insensitive to the chromosomal region maintenance 1 (CRM1) inhibitor leptomycin B (LMB) or to CRM1 knockdown. However, knockdown of calreticulin (CRT) prevented NES-mediated nuclear export. Furthermore, our data show that CRT interacts with LRH-1 and is involved in the nuclear export of LRH-1. With full-length LRH-1, mutation of NES1 led to perinuclear accumulation of the mutant protein. Immunofluorescence analysis showed that these perinuclear aggregates were co-localized with the centrosome marker, microtubule-associated protein 1 light chain 3 (LC3), ubiquitin and heat shock protein 70 (Hsp70), indicating that the mutant was misfolded and sequestered into aggresome-like structures via the autophagic clearance pathway. Our study demonstrates for the first time that LRH-1 has a CRT-dependent NES which is not only required for cytoplasmic trafficking, but also essential for correct protein folding to avoid misfolding-induced aggregation. © 2015 Authors; published by Portland Press Limited.

  2. Current food safety management systems in fish-exporting companies require further improvements to adequately cope with contextual pressure: case study.

    PubMed

    Onjong, Hillary Adawo; Wangoh, John; Njage, Patrick Murigu Kamau

    2014-10-01

    Fish-processing plants still face food safety (FS) challenges worldwide despite the existence of several quality assurance standards and food safety management systems/s (FSMSs). This study assessed performance of FSMS in fish exporting sector considering pressure from the context in which they operate. A FSMS diagnostic tool with checklist was used to assess the context, FSMS, and FS output in 9 Kenyan fish exporting companies. Majority (67%) companies operated at moderate- to high-risk context but with an average performance in control and assurance activities. This situation could be insufficient to deal with ambiguity, uncertainty, and vulnerability issues in the context characteristics. Contextual risk posed by product characteristics (nature of raw materials) and chain environment characteristics was high. Risk posed by the chain environment characteristics, low power in supplier relationships, and low degree of authority in customer relationships was high. Lack of authority in relationship with suppliers would lead to high raw material risk situation. Even though cooling facilities, a key control activity, was at an advanced level, there was inadequate packaging intervention equipment which coupled with inadequate physical intervention equipment could lead to further weakened FSMS performance. For the fish companies to improve their FSMS to higher level and enhance predictability, they should base their FSMS on scientific information sources, historical results, and own experimental trials in their preventive, intervention, and monitoring systems. Specific suggestions are derived for improvements toward higher FSMS activity levels or lower risk levels in context characteristics. Weak areas in performance of control and assurance activities in export fish-processing sector already implementing current quality assurance guidelines and standards were studied taking into consideration contextual pressure wherein the companies operate. Important mitigation measures toward improved contextual risk, core assurance, and control activities irrespective of applied food safety management systems in fish industries were suggested. © 2014 Institute of Food Technologists®

  3. Hepatocytes traffic and export hepatitis B virus basolaterally by polarity-dependent mechanisms.

    PubMed

    Bhat, Purnima; Snooks, Michelle J; Anderson, David A

    2011-12-01

    Viruses commonly utilize the cellular trafficking machinery of polarized cells to effect viral export. Hepatocytes are polarized in vivo, but most in vitro hepatocyte models are either nonpolarized or have morphology unsuitable for the study of viral export. Here, we investigate the mechanisms of trafficking and export for the hepadnaviruses hepatitis B virus (HBV) and duck hepatitis B virus (DHBV) in polarized hepatocyte-derived cell lines and primary duck hepatocytes. DHBV export, but not replication, was dependent on the development of hepatocyte polarity, with export significantly abrogated over time as primary hepatocytes lost polarity. Using Transwell cultures of polarized N6 cells and adenovirus-based transduction, we observed that export of both HBV and DHBV was vectorially regulated and predominantly basolateral. Monitoring of polarized N6 cells and nonpolarized C11 cells during persistent, long-term DHBV infection demonstrated that newly synthesized sphingolipid and virus displayed significant colocalization and fluorescence resonance energy transfer, implying cotransportation from the Golgi complex to the plasma membrane. Notably, 15% of virus was released apically from polarized cells, corresponding to secretion into the bile duct in vivo, also in association with sphingolipids. We conclude that DHBV and, probably, HBV are reliant upon hepatocyte polarity to be efficiently exported and this export is in association with sphingolipid structures, possibly lipid rafts. This study provides novel insights regarding the mechanisms of hepadnavirus trafficking in hepatocytes, with potential relevance to pathogenesis and immune tolerance.

  4. How can we reduce phosphorus export from lowland polders? Implications from a sensitivity analysis of a coupled model.

    PubMed

    Huang, Jiacong; Gao, Junfeng; Yan, Renhua

    2016-08-15

    Phosphorus (P) export from lowland polders has caused severe water pollution. Numerical models are an important resource that help water managers control P export. This study coupled three models, i.e., Phosphorus Dynamic model for Polders (PDP), Integrated Catchments model of Phosphorus dynamics (INCA-P) and Universal Soil Loss Equation (USLE), to describe the P dynamics in polders. Based on the coupled models and a dataset collected from Polder Jian in China, sensitivity analysis were carried out to analyze the cause-effect relationships between environmental factors and P export from Polder Jian. The sensitivity analysis results showed that P export from Polder Jian were strongly affected by air temperature, precipitation and fertilization. Proper fertilization management should be a strategic priority for reducing P export from Polder Jian. This study demonstrated the success of model coupling, and its application in investigating potential strategies to support pollution control in polder systems. Copyright © 2016. Published by Elsevier B.V.

  5. Assessing drivers of export orientation in the subsea oil and gas industry.

    PubMed

    Aarstad, Jarle; Pettersen, Inger Beate; Jakobsen, Stig-Erik

    2015-01-01

    The purpose of this short study was to identify the drivers of export orientation of firms in the subsea oil and gas industry in Western Norway. As the oil fields in the North Sea are approaching a stage of maturity, gaining knowledge of these drivers is crucial. An online survey was conducted of firms operating in the subsea oil and gas industry in the region. Consistent with previous research, the data reveal that product innovation and a majority share of international ownership increase firms' export rates. The use of instrumental variables indicates that both product innovation and international ownership are causes of subsea petroleum exports. The study moreover finds that subcontractors have a lower rate of direct exports than system providers, but international ownership in particular boosts subcontractors' export rates, probably by decreasing their market dependency on regional system providers. A clear recommendation for managers and stakeholders is that they should encourage foreign investments throughout the value chain. The results of such a strategy appear to be especially positive for subcontractors.

  6. 27 CFR 28.301 - Loss of distilled spirits in transit.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ...) the vessel or aircraft, (d) the foreign-trade zone, or (e) the customs bonded warehouse, as the case... negligence on the part of the exporter, owner, consignor, consignee, bailee, or carrier or the employees or agents of any of them: Provided, That such remission in the case of loss of distilled spirits by theft...

  7. Insights into the nuclear export of murine leukemia virus intron-containing RNA.

    PubMed

    Pessel-Vivares, Lucie; Houzet, Laurent; Lainé, Sébastien; Mougel, Marylène

    2015-01-01

    The retroviral genome consists of an intron-containing transcript that has essential cytoplasmic functions in the infected cell. This viral transcript can escape splicing, circumvent the nuclear checkpoint mechanisms and be transported to the cytoplasm by hijacking the host machinery. Once in the cytoplasm, viral unspliced RNA acts as mRNA to be translated and as genomic RNA to be packaged into nascent viruses. The murine leukemia virus (MLV) is among the first retroviruses discovered and is classified as simple Retroviridae due to its minimal encoding capacity. The oncogenic and transduction abilities of MLV are extensively studied, whereas surprisingly the crucial step of its nuclear export has remained unsolved until 2014. Recent work has revealed the recruitment by MLV of the cellular NXF1/Tap-dependent pathway for export. Unconventionally, MLV uses of Tap to export both spliced and unspliced viral RNAs. Unlike other retroviruses, MLV does not harbor a unique RNA signal for export. Indeed, multiple sequences throughout the MLV genome appear to promote export of the unspliced MLV RNA. We review here the current understanding of the export mechanism and highlight the determinants that influence MLV export. As the molecular mechanism of MLV export is elucidated, we will gain insight into the contribution of the export pathway to the cytoplasmic fate of the viral RNA.

  8. International trade of health services: global trends and local impact.

    PubMed

    Lautier, Marc

    2014-10-01

    Globalization is a key challenge facing health policy-makers. A significant dimension of this is trade in health services. Traditionally, the flow of health services exports went from North to South, with patients travelling in the opposite direction. This situation is changing and a number of papers have discussed the growth of health services exports from Southern countries in its different dimensions. Less attention has been paid to assess the real scope of this trade at the global level and its potential impact at the local level. Given the rapid development of this area, there are little empirical data. This paper therefore first built an estimate of the global size and of the growth trend of international trade in health services since 1997, which is compared with several country-based studies. The second purpose of the paper is to demonstrate the significant economic impact of this trade at the local level for the exporting country. We consider the case of health providers in the South-Mediterranean region for which the demand potential, the economic effects and the consequence for the health system are presented. These issues lead to the overall conclusion that different policy options would be appropriate, in relation to the nature of the demand. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

  9. Reconsidering non-traditional export agriculture and household food security: A case study in rural Guatemala

    PubMed Central

    Bennett, Elena M.

    2018-01-01

    As the production of non-traditional export (NTX) crops by smallholder households in developing countries expands, there is a compelling need to understand the potential effects of this type of agricultural production on household food security and nutrition. We use two household surveys with a sample of 52 households, interviews, and focus groups to examine whether smallholder farmers who produce broccoli for export in a rural Guatemalan community have different household food security than farmers in the same community who are still growing traditional maize and bean crops. We explore and compare the food security status of broccoli farmers (adopters) and traditional farmers (non-adopters) across four dimensions of food security: availability, access, utilization, and stability. Adopters earned significantly more income (40%) than non-adopters, but higher incomes did not coincide with improvements in food availability, food access, or food utilization. Results indicate that adopters and non-adopters alike struggle with access to food, while the intensity of broccoli production may be undermining the ability of local agricultural systems to naturally control pests and regulate nutrients. More systematic approaches to food security assessment, especially those that consider all four dimensions of food security, are needed to better target interventions designed to alleviate food insecurity among rural smallholders. PMID:29795691

  10. Reconsidering non-traditional export agriculture and household food security: A case study in rural Guatemala.

    PubMed

    Méthot, Josée; Bennett, Elena M

    2018-01-01

    As the production of non-traditional export (NTX) crops by smallholder households in developing countries expands, there is a compelling need to understand the potential effects of this type of agricultural production on household food security and nutrition. We use two household surveys with a sample of 52 households, interviews, and focus groups to examine whether smallholder farmers who produce broccoli for export in a rural Guatemalan community have different household food security than farmers in the same community who are still growing traditional maize and bean crops. We explore and compare the food security status of broccoli farmers (adopters) and traditional farmers (non-adopters) across four dimensions of food security: availability, access, utilization, and stability. Adopters earned significantly more income (40%) than non-adopters, but higher incomes did not coincide with improvements in food availability, food access, or food utilization. Results indicate that adopters and non-adopters alike struggle with access to food, while the intensity of broccoli production may be undermining the ability of local agricultural systems to naturally control pests and regulate nutrients. More systematic approaches to food security assessment, especially those that consider all four dimensions of food security, are needed to better target interventions designed to alleviate food insecurity among rural smallholders.

  11. Measuring the globalization of cities from the new regionalism perspective.

    PubMed

    Ergüzel, Oylum Şehvez; Tunahan, Hakan; Esen, Sinan

    2016-01-01

    The study aims to analyze the export performance of countries and of cities within them to identify synchronized or unsynchronized movement between them. In the empirical part of the study, the measurements used to analyze the export performance of the countries included in the literature are applied to establish the export performance of a single city-Sakarya, Turkey. These measurements include the Herfindahl-Hirchman product and market concentration indices, the Lawrence index, the trade complementarity index, and the Grubel-Lloyd intra-industry index, as well as additional indicators with local or regional contexts. The limited number of studies analyzing the export competitiveness of a single city with relevant formats in the literature reveal the significance of the study.

  12. 27 CFR 28.310 - Loss of specially denatured spirits in transit.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... the case may be, may be allowed if evidence satisfactory to the appropriate TTB officer establishes... of any connivance, collusion, fraud, or negligence on the part of the exporter, owner, consignor...

  13. 27 CFR 28.303 - Filing of claims.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... connivance, collusion, fraud, or negligence on the part of the exporter, owner, consignor, consignee, bailee, or carrier, or the employees or agents of any of them; (j) In the case of a loss by theft, whether...

  14. A non-canonical mechanism for Crm1-export cargo complex assembly

    PubMed Central

    Fischer, Ute; Schäuble, Nico; Schütz, Sabina; Altvater, Martin; Chang, Yiming; Boulos Faza, Marius; Panse, Vikram Govind

    2015-01-01

    The transport receptor Crm1 mediates the export of diverse cargos containing leucine-rich nuclear export signals (NESs) through complex formation with RanGTP. To ensure efficient cargo release in the cytoplasm, NESs have evolved to display low affinity for Crm1. However, mechanisms that overcome low affinity to assemble Crm1-export complexes in the nucleus remain poorly understood. In this study, we reveal a new type of RanGTP-binding protein, Slx9, which facilitates Crm1 recruitment to the 40S pre-ribosome-associated NES-containing adaptor Rio2. In vitro, Slx9 binds Rio2 and RanGTP, forming a complex. This complex directly loads Crm1, unveiling a non-canonical stepwise mechanism to assemble a Crm1-export complex. A mutation in Slx9 that impairs Crm1-export complex assembly inhibits 40S pre-ribosome export. Thus, Slx9 functions as a scaffold to optimally present RanGTP and the NES to Crm1, therefore, triggering 40S pre-ribosome export. This mechanism could represent one solution to the paradox of weak binding events underlying rapid Crm1-mediated export. DOI: http://dx.doi.org/10.7554/eLife.05745.001 PMID:25895666

  15. Twelve year interannual and seasonal variability of stream carbon export from a boreal peatland catchment

    NASA Astrophysics Data System (ADS)

    Leach, J. A.; Larsson, A.; Wallin, M. B.; Nilsson, M. B.; Laudon, H.

    2016-07-01

    Understanding stream carbon export dynamics is needed to accurately predict how the carbon balance of peatland catchments will respond to climatic and environmental change. We used a 12 year record (2003-2014) of continuous streamflow and manual spot measurements of total organic carbon (TOC), dissolved inorganic carbon (DIC), methane (CH4), and organic carbon quality (carbon-specific ultraviolet absorbance at 254 nm per dissolved organic carbon) to assess interannual and seasonal variability in stream carbon export for a peatland catchment (70% mire and 30% forest cover) in northern Sweden. Mean annual total carbon export for the 12 year period was 12.2 gCm-2 yr-1, but individual years ranged between 6 and 18 gCm-2 yr-1. TOC, which was primarily composed of dissolved organic carbon (>99%), was the dominant form of carbon being exported, comprising 63% to 79% of total annual exports, and DIC contributed between 19% and 33%. CH4 made up less than 5% of total export. When compared to previously published annual net ecosystem exchange (NEE) for the studied peatland system, stream carbon export typically accounted for 12 to 50% of NEE for most years. However, in 2006 stream carbon export accounted for 63 to 90% (estimated uncertainty range) of NEE due to a dry summer which suppressed NEE, followed by a wet autumn that resulted in considerable stream export. Runoff exerted a primary control on stream carbon export from this catchment; however, our findings suggest that seasonal variations in biologic and hydrologic processes responsible for production and transport of carbon within the peatland were secondary influences on stream carbon export. Consideration of these seasonal dynamics is needed when predicting stream carbon export response to environmental change.

  16. Uncapped mRNA introduced into tobacco protoplasts can be imported into the nucleus and is trapped by leptomycin B.

    PubMed

    Stuger, Rogier; Forreiter, Christoph

    2004-08-01

    The mechanism of nuclear export of RNAs in yeast and animal cells is rapidly being uncovered, but RNA export in plants has received little attention. We introduced capped and uncapped fluorescent mRNAs into tobacco (Nicotiana plumbaginifolia) protoplasts and studied their cellular localization. Following insertion, capped transcripts were found in the cytoplasm, while uncapped messengers transiently appeared in the nucleus in about one-quarter to one-third of the cells. These mRNAs were trapped by the nuclear export-inhibiting drug leptomycin B, pointing to an export mechanism in plants similar to Rev-NES-mediated RNP export in other organisms.

  17. MODELING MINERAL NITROGEN EXPORT FROM A FOREST TERRESTRIAL ECOSYSTEM TO STREAMS

    EPA Science Inventory

    Terrestrial ecosystems are major sources of N pollution to aquatic ecosystems. Predicting N export to streams is a critical goal of non-point source modeling. This study was conducted to assess the effect of terrestrial N cycling on stream N export using long-term monitoring da...

  18. KMWin--a convenient tool for graphical presentation of results from Kaplan-Meier survival time analysis.

    PubMed

    Gross, Arnd; Ziepert, Marita; Scholz, Markus

    2012-01-01

    Analysis of clinical studies often necessitates multiple graphical representations of the results. Many professional software packages are available for this purpose. Most packages are either only commercially available or hard to use especially if one aims to generate or customize a huge number of similar graphical outputs. We developed a new, freely available software tool called KMWin (Kaplan-Meier for Windows) facilitating Kaplan-Meier survival time analysis. KMWin is based on the statistical software environment R and provides an easy to use graphical interface. Survival time data can be supplied as SPSS (sav), SAS export (xpt) or text file (dat), which is also a common export format of other applications such as Excel. Figures can directly be exported in any graphical file format supported by R. On the basis of a working example, we demonstrate how to use KMWin and present its main functions. We show how to control the interface, customize the graphical output, and analyse survival time data. A number of comparisons are performed between KMWin and SPSS regarding graphical output, statistical output, data management and development. Although the general functionality of SPSS is larger, KMWin comprises a number of features useful for survival time analysis in clinical trials and other applications. These are for example number of cases and number of cases under risk within the figure or provision of a queue system for repetitive analyses of updated data sets. Moreover, major adjustments of graphical settings can be performed easily on a single window. We conclude that our tool is well suited and convenient for repetitive analyses of survival time data. It can be used by non-statisticians and provides often used functions as well as functions which are not supplied by standard software packages. The software is routinely applied in several clinical study groups.

  19. KMWin – A Convenient Tool for Graphical Presentation of Results from Kaplan-Meier Survival Time Analysis

    PubMed Central

    Gross, Arnd; Ziepert, Marita; Scholz, Markus

    2012-01-01

    Background Analysis of clinical studies often necessitates multiple graphical representations of the results. Many professional software packages are available for this purpose. Most packages are either only commercially available or hard to use especially if one aims to generate or customize a huge number of similar graphical outputs. We developed a new, freely available software tool called KMWin (Kaplan-Meier for Windows) facilitating Kaplan-Meier survival time analysis. KMWin is based on the statistical software environment R and provides an easy to use graphical interface. Survival time data can be supplied as SPSS (sav), SAS export (xpt) or text file (dat), which is also a common export format of other applications such as Excel. Figures can directly be exported in any graphical file format supported by R. Results On the basis of a working example, we demonstrate how to use KMWin and present its main functions. We show how to control the interface, customize the graphical output, and analyse survival time data. A number of comparisons are performed between KMWin and SPSS regarding graphical output, statistical output, data management and development. Although the general functionality of SPSS is larger, KMWin comprises a number of features useful for survival time analysis in clinical trials and other applications. These are for example number of cases and number of cases under risk within the figure or provision of a queue system for repetitive analyses of updated data sets. Moreover, major adjustments of graphical settings can be performed easily on a single window. Conclusions We conclude that our tool is well suited and convenient for repetitive analyses of survival time data. It can be used by non-statisticians and provides often used functions as well as functions which are not supplied by standard software packages. The software is routinely applied in several clinical study groups. PMID:22723912

  20. A General Safety Assessment for Purified Food Ingredients Derived From Biotechnology Crops: Case Study of Brazilian Sugar and Beverages Produced From Insect-Protected Sugarcane.

    PubMed

    Kennedy, Reese D; Cheavegatti-Gianotto, Adriana; de Oliveira, Wladecir S; Lirette, Ronald P; Hjelle, Jerry J

    2018-01-01

    Insect-protected sugarcane that expresses Cry1Ab has been developed in Brazil. Analysis of trade information has shown that effectively all the sugarcane-derived Brazilian exports are raw or refined sugar and ethanol. The fact that raw and refined sugar are highly purified food ingredients, with no detectable transgenic protein, provides an interesting case study of a generalized safety assessment approach. In this study, both the theoretical protein intakes and safety assessments of Cry1Ab, Cry1Ac, NPTII, and Bar proteins used in insect-protected biotechnology crops were examined. The potential consumption of these proteins was examined using local market research data of average added sugar intakes in eight diverse and representative Brazilian raw and refined sugar export markets (Brazil, Canada, China, Indonesia, India, Japan, Russia, and the USA). The average sugar intakes, which ranged from 5.1 g of added sugar/person/day (India) to 126 g sugar/p/day (USA) were used to calculated possible human exposure. The theoretical protein intake estimates were carried out in the "Worst-case" scenario, assumed that 1 μg of newly-expressed protein is detected/g of raw or refined sugar; and the "Reasonable-case" scenario assumed 1 ng protein/g sugar. The "Worst-case" scenario was based on results of detailed studies of sugarcane processing in Brazil that showed that refined sugar contains less than 1 μg of total plant protein /g refined sugar. The "Reasonable-case" scenario was based on assumption that the expression levels in stalk of newly-expressed proteins were less than 0.1% of total stalk protein. Using these calculated protein intake values from the consumption of sugar, along with the accepted NOAEL levels of the four representative proteins we concluded that safety margins for the "Worst-case" scenario ranged from 6.9 × 10 5 to 5.9 × 10 7 and for the "Reasonable-case" scenario ranged from 6.9 × 10 8 to 5.9 × 10 10 . These safety margins are very high due to the extremely low possible exposures and the high NOAELs for these non-toxic proteins. This generalized approach to the safety assessment of highly purified food ingredients like sugar illustrates that sugar processed from Brazilian GM varieties are safe for consumption in representative markets globally.

  1. Hydrological and water quality impact assessment of a Mediterranean limno-reservoir under climate change and land use management scenarios

    NASA Astrophysics Data System (ADS)

    Molina-Navarro, Eugenio; Trolle, Dennis; Martínez-Pérez, Silvia; Sastre-Merlín, Antonio; Jeppesen, Erik

    2014-02-01

    Water scarcity and water pollution constitute a big challenge for water managers in the Mediterranean region today and will exacerbate in a projected future warmer world, making a holistic approach for water resources management at the catchment scale essential. We expanded the Soil and Water Assessment Tool (SWAT) model developed for a small Mediterranean catchment to quantify the potential effects of various climate and land use change scenarios on catchment hydrology as well as the trophic state of a new kind of waterbody, a limno-reservoir (Pareja Limno-reservoir), created for environmental and recreational purposes. We also checked for the possible synergistic effects of changes in climate and land use on water flow and nutrient exports from the catchment. Simulations showed a noticeable impact of climate change in the river flow regime and consequently the water level of the limno-reservoir, especially during summer, complicating the fulfillment of its purposes. Most of the scenarios also predicted a deterioration of trophic conditions in the limno-reservoir. Fertilization and soil erosion were the main factors affecting nitrate and total phosphorus concentrations. Combined climate and land use change scenarios showed noticeable synergistic effects on nutrients exports, relative to running the scenarios individually. While the impact of fertilization on nitrate export is projected to be reduced with warming in most cases, an additional 13% increase in the total phosphorus export is expected in the worst-case combined scenario compared to the sum of individual scenarios. Our model framework may help water managers to assess and manage how these multiple environmental stressors interact and ultimately affect aquatic ecosystems.

  2. The production and exportation of artemisinin-derived drugs in China: current status and existing challenges.

    PubMed

    Huang, Yangmu; Li, Hui; Peng, Danlu; Wang, Yu; Ren, Qiaomeng; Guo, Yan

    2016-07-15

    As the discoverer and a major manufacturer of artemisinin, China has made valuable contributions to malaria control and the global market of artemisinin-derived drugs. This study aims to explore the production and export status of artemisinin-derived drugs in China during 2011 and 2014 to provide a clear understanding of China's participation in this field and also to provide guidance for its future role on global malaria control. Production and exportation data were obtained from the Ministry of Industry and Information Technology (MIIT) database of the People's Republic China and monthly reports of the General Administration of Customs of China, respectively. The production volume, export volume, export value, and export area of artemisinin and its derivatives (artemether, artesunate, dihydroartemisinin), including both active pharmaceutical ingredients (APIs) and finished pharmaceutical products (FPPs), were descripted and analysed by Microsoft Excel. Between 2011 and 2013, the total production volume of artemisinin-derived APIs and FPPs reached 543.41 metric tons (MT) and 14.79 MT, respectively. The total export value and volume of artemisinin-derived APIs during 2012 and 2014 was US$ 211.39 million and 338.53 MT; the total export value and volume of FPPs was US$ 227.17 million and 4401.44 MT. Compared with the sharply decreasing trend of API exports each year, the export value of FPPs kept at a more stable level, with 14.66 % increase in 2013 and 5.31 % decrease in 2014. As for exportation areas, India was the largest purchaser of APIs, accounting for nearly a half of the total amount, while FPPs mainly exported to African countries. Exports of artemisinin derivatives for China have been transforming from API-dominated to FPP-dominated. However, the exportation of artemisinin-derived drugs in China still face the challenges of small market share in the global FPP market and indirect sale of FPPs through a third country due to the deficiency in obtaining relevant certification into global market.

  3. An Identification and Analysis of Students' Expectations and Views regarding Foreign-Sourced Tertiary Education Programs Delivered in China: Investigating the Next Stage of Internationalisation and Market Entry for Foreign Universities

    ERIC Educational Resources Information Center

    Willis, Mike

    2005-01-01

    There has been a wealth of research into various forms of educational export such as distance education and study abroad, but this paper focuses on the delivery of foreign-supplied courses and programs "within" a host country-in this case, China. Key findings include a high level of demand amongst Chinese students for business and…

  4. 15 CFR Supplement No. 1 to Part 766 - Guidance on Charging and Penalty Determinations in Settlement of Administrative Enforcement Cases

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... based on nuclear, biological, and chemical weapon proliferation, missile technology proliferation, and... are relevant to the application of this guidance to their cases, to whether a violation has in fact... question—for example, export of items subject to nuclear controls to a country with a poor record of...

  5. 15 CFR Supplement No. 1 to Part 766 - Guidance on Charging and Penalty Determinations in Settlement of Administrative Enforcement Cases

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... based on nuclear, biological, and chemical weapon proliferation, missile technology proliferation, and... are relevant to the application of this guidance to their cases, to whether a violation has in fact... question—for example, export of items subject to nuclear controls to a country with a poor record of...

  6. Dynamics of the pneumonic plague epidemic in Madagascar, August to October 2017.

    PubMed

    Tsuzuki, Shinya; Lee, Hyojung; Miura, Fuminari; Chan, Yat Hin; Jung, Sung-Mok; Akhmetzhanov, Andrei R; Nishiura, Hiroshi

    2017-11-01

    Transmission potential and severity of pneumonic plague in Madagascar were assessed. Accounting for reporting delay, the reproduction number was estimated at 1.73. The case fatality risk was estimated as 5.5%. Expected numbers of exported cases from Madagascar were estimated across the world and all estimates were below 1 person from August to October, 2017.

  7. Changing gender roles and health impacts among female workers in export-processing industries in Sri Lanka.

    PubMed

    Attanapola, Chamila T

    2004-06-01

    Since the economic liberalization in 1977, a large number of Sri Lankan women have entered the labour market and engaged in income-generating activities. Some women choose to travel abroad as domestic workers, while others choose to work in export-processing industries. This process has a profound impact on gender and gender roles in Sri Lanka. Young rural women have changed their traditional women's roles to become independent daughters, efficient factory workers and partially modernized women. Even though changing gender roles are identified as a positive impact of industrial work, the new social, cultural, and legal environments of industrial work have negative impacts on these women's lives. This paper explores health impacts of changing gender roles and practices of young rural women, focusing on the experiences of female workers in export-processing industries. Further, it contributes to the literature on gender and health, and on qualitative approaches within health geographic studies. A model is formulated to suggest a conceptual framework for studying women's health. The model describes the determinant factors of individual health status based on the question of who (personal attributes) does what (type of work) where (place), when and how (behaviours). These are also determinant factors of gender and gender roles of a society. The three types of health problems (reproductive, productive and mental health) of a woman, in this case a female industrial worker, are determined by her gender roles and practices associated with these roles.

  8. Ran-dependent nuclear export mediators: a structural perspective

    PubMed Central

    Güttler, Thomas; Görlich, Dirk

    2011-01-01

    Nuclear export is an essential eukaryotic activity. It proceeds through nuclear pore complexes (NPCs) and is mediated by soluble receptors that shuttle between nucleus and cytoplasm. RanGTPase-dependent export mediators (exportins) constitute the largest class of these carriers and are functionally highly versatile. All of these exportins load their substrates in response to RanGTP binding in the nucleus and traverse NPCs as ternary RanGTP–exportin–cargo complexes to the cytoplasm, where GTP hydrolysis leads to export complex disassembly. The different exportins vary greatly in their substrate range. Recent structural studies of both protein- and RNA-specific exporters have illuminated how exportins bind their cargoes, how Ran triggers cargo loading and how export complexes are disassembled in the cytoplasm. Here, we review the current state of knowledge and highlight emerging principles as well as prevailing questions. PMID:21878989

  9. Impact of the natural Fe-fertilization on the magnitude, stoichiometry and efficiency of particulate biogenic silica, nitrogen and iron export fluxes

    NASA Astrophysics Data System (ADS)

    Lemaitre, N.; Planquette, H.; Dehairs, F.; van der Merwe, P.; Bowie, A. R.; Trull, T. W.; Laurenceau-Cornec, E. C.; Davies, D.; Bollinger, C.; Le Goff, M.; Grossteffan, E.; Planchon, F.

    2016-11-01

    The Kerguelen Plateau is characterized by a naturally Fe-fertilized phytoplankton bloom that extends more than 1000 km downstream in the Antarctic Circumpolar Current. During the KEOPS2 study, in austral spring, we measured particulate nitrogen (PN), biogenic silica (BSi) and particulate iron (PFe) export fluxes in order to investigate how the natural fertilization impacts the stoichiometry and the magnitude of export fluxes and therefore the efficiency of the biological carbon pump. At 9 stations, we estimated elemental export fluxes based on element concentration to 234Th activity ratios for particulate material collected with in-situ pumps and 234Th export fluxes (Planchon et al., 2015). This study revealed that the natural Fe-fertilization increased export fluxes but to variable degrees. Export fluxes for the bloom impacted area were compared with those of a high-nutrient, low-chlorophyll (HNLC), low-productive reference site located to the south-west of Kerguelen and which had the lowest BSi and PFe export fluxes (2.55 mmol BSi m-2 d-1 and 1.92 μmol PFem-2 d-1) and amongst the lowest PN export flux (0.73 mmol PN m-2 d-1). The impact of the Fe fertilization was the greatest within a meander of the polar front (PF), to the east of Kerguelen, with fluxes reaching 1.26 mmol PN m-2 d-1; 20.4 mmol BSi m-2 d-1 and 22.4 μmol PFe m-2 d-1. A highly productive site above the Kerguelen Plateau, on the contrary, was less impacted by the fertilization with export fluxes reaching 0.72 mmol PN m-2 d-1; 4.50 mmol BSi m-2 d-1 and 21.4 μmol PFe m-2 d-1. Our results suggest that ecosystem features (i.e. type of diatom community) could play an important role in setting the magnitude of export fluxes of these elements. Indeed, for the PF meander, the moderate productivity was sustained by the presence of large and strongly silicified diatom species while at the higher productivity sites, smaller and slightly silicified diatoms dominated. Interestingly, our results suggest that PFe export fluxes can be driven by the lithogenic pool of particles, especially over the Plateau where such inputs from the sediments are important. Finally, for the Plateau and the PF meander, the comparison between PFe export and the particulate PFe stock integrated over the mixed layer depth revealed an efficient PFe export out of the mixed layer at these sites. Export efficiencies (i.e. the ratio between export and uptake) exhibit a very efficient silica pump especially at the HNLC reference station where heavily silicified diatoms were present. On the contrary, the increase with depth of the C:N ratio and the low nitrogen export efficiencies support the idea of a strong remineralization and nitrification activity.

  10. Protein kinase A is part of a mechanism that regulates nuclear reimport of the nuclear tRNA export receptors Los1p and Msn5p.

    PubMed

    Pierce, Jacqueline B; van der Merwe, George; Mangroo, Dev

    2014-02-01

    The two main signal transduction mechanisms that allow eukaryotes to sense and respond to changes in glucose availability in the environment are the cyclic AMP (cAMP)/protein kinase A (PKA) and AMP-activated protein kinase (AMPK)/Snf1 kinase-dependent pathways. Previous studies have shown that the nuclear tRNA export process is inhibited in Saccharomyces cerevisiae deprived of glucose. However, the signal transduction pathway involved and the mechanism by which glucose availability regulates nuclear-cytoplasmic tRNA trafficking are not understood. Here, we show that inhibition of nuclear tRNA export is caused by a block in nuclear reimport of the tRNA export receptors during glucose deprivation. Cytoplasmic accumulation of the tRNA export receptors during glucose deprivation is not caused by activation of Snf1p. Evidence obtained suggests that PKA is part of the mechanism that regulates nuclear reimport of the tRNA export receptors in response to glucose availability. This mechanism does not appear to involve phosphorylation of the nuclear tRNA export receptors by PKA. The block in nuclear reimport of the tRNA export receptors appears to be caused by activation of an unidentified mechanism when PKA is turned off during glucose deprivation. Taken together, the data suggest that PKA facilitates return of the tRNA export receptors to the nucleus by inhibiting an unidentified activity that facilitates cytoplasmic accumulation of the tRNA export receptors when glucose in the environment is limiting. A PKA-independent mechanism was also found to regulate nuclear tRNA export in response to glucose availability. This mechanism, however, does not regulate nuclear reimport of the tRNA export receptors.

  11. Protein Kinase A Is Part of a Mechanism That Regulates Nuclear Reimport of the Nuclear tRNA Export Receptors Los1p and Msn5p

    PubMed Central

    Pierce, Jacqueline B.; van der Merwe, George

    2014-01-01

    The two main signal transduction mechanisms that allow eukaryotes to sense and respond to changes in glucose availability in the environment are the cyclic AMP (cAMP)/protein kinase A (PKA) and AMP-activated protein kinase (AMPK)/Snf1 kinase-dependent pathways. Previous studies have shown that the nuclear tRNA export process is inhibited in Saccharomyces cerevisiae deprived of glucose. However, the signal transduction pathway involved and the mechanism by which glucose availability regulates nuclear-cytoplasmic tRNA trafficking are not understood. Here, we show that inhibition of nuclear tRNA export is caused by a block in nuclear reimport of the tRNA export receptors during glucose deprivation. Cytoplasmic accumulation of the tRNA export receptors during glucose deprivation is not caused by activation of Snf1p. Evidence obtained suggests that PKA is part of the mechanism that regulates nuclear reimport of the tRNA export receptors in response to glucose availability. This mechanism does not appear to involve phosphorylation of the nuclear tRNA export receptors by PKA. The block in nuclear reimport of the tRNA export receptors appears to be caused by activation of an unidentified mechanism when PKA is turned off during glucose deprivation. Taken together, the data suggest that PKA facilitates return of the tRNA export receptors to the nucleus by inhibiting an unidentified activity that facilitates cytoplasmic accumulation of the tRNA export receptors when glucose in the environment is limiting. A PKA-independent mechanism was also found to regulate nuclear tRNA export in response to glucose availability. This mechanism, however, does not regulate nuclear reimport of the tRNA export receptors. PMID:24297441

  12. Global patterns of organic carbon export and sequestration in the ocean (Arne Richter Award for Outstanding Young Scientists)

    NASA Astrophysics Data System (ADS)

    Henson, S.; Sanders, R.; Madsen, E.; Le Moigne, F.; Quartly, G.

    2012-04-01

    A major term in the global carbon cycle is the ocean's biological carbon pump which is dominated by sinking of small organic particles from the surface ocean to its interior. Here we examine global patterns in particle export efficiency (PEeff), the proportion of primary production that is exported from the surface ocean, and transfer efficiency (Teff), the fraction of exported organic matter that reaches the deep ocean. This is achieved through extrapolating from in situ estimates of particulate organic carbon export to the global scale using satellite-derived data. Global scale estimates derived from satellite data show, in keeping with earlier studies, that PEeff is high at high latitudes and low at low latitudes, but that Teff is low at high latitudes and high at low latitudes. However, in contrast to the relationship observed for deep biomineral fluxes in previous studies, we find that Teff is strongly negatively correlated with opal export flux from the upper ocean, but uncorrelated with calcium carbonate export flux. We hypothesise that the underlying factor governing the spatial patterns observed in Teff is ecosystem function, specifically the degree of recycling occurring in the upper ocean, rather than the availability of calcium carbonate for ballasting. Finally, our estimate of global integrated carbon export is only 50% of previous estimates. The lack of consensus amongst different methodologies on the strength of the biological carbon pump emphasises that our knowledge of a major planetary carbon flux remains incomplete.

  13. Protein Export by the Mycobacterial SecA2 System Is Determined by the Preprotein Mature Domain

    PubMed Central

    Feltcher, Meghan E.; Gibbons, Henry S.; Ligon, Lauren S.

    2013-01-01

    At the core of the bacterial general secretion (Sec) pathway is the SecA ATPase, which powers translocation of unfolded preproteins containing Sec signal sequences through the SecYEG membrane channel. Mycobacteria have two nonredundant SecA homologs: SecA1 and SecA2. While the essential SecA1 handles “housekeeping” export, the nonessential SecA2 exports a subset of proteins and is required for Mycobacterium tuberculosis virulence. Currently, it is not understood how SecA2 contributes to Sec export in mycobacteria. In this study, we focused on identifying the features of two SecA2 substrates that target them to SecA2 for export, the Ms1704 and Ms1712 lipoproteins of the model organism Mycobacterium smegmatis. We found that the mature domains of Ms1704 and Ms1712, not the N-terminal signal sequences, confer SecA2-dependent export. We also demonstrated that the lipid modification and the extreme N terminus of the mature protein do not impart the requirement for SecA2 in export. We further showed that the Ms1704 mature domain can be efficiently exported by the twin-arginine translocation (Tat) pathway. Because the Tat system exports only folded proteins, this result implies that SecA2 substrates can fold in the cytoplasm and suggests a putative role of SecA2 in enabling export of such proteins. Thus, the mycobacterial SecA2 system may represent another way that bacteria solve the problem of exporting proteins that can fold in the cytoplasm. PMID:23204463

  14. Assessment of Automatically Exported Clinical Data from a Hospital Information System for Clinical Research in Multiple Myeloma.

    PubMed

    Torres, Viviana; Cerda, Mauricio; Knaup, Petra; Löpprich, Martin

    2016-01-01

    An important part of the electronic information available in Hospital Information System (HIS) has the potential to be automatically exported to Electronic Data Capture (EDC) platforms for improving clinical research. This automation has the advantage of reducing manual data transcription, a time consuming and prone to errors process. However, quantitative evaluations of the process of exporting data from a HIS to an EDC system have not been reported extensively, in particular comparing with manual transcription. In this work an assessment to study the quality of an automatic export process, focused in laboratory data from a HIS is presented. Quality of the laboratory data was assessed in two types of processes: (1) a manual process of data transcription, and (2) an automatic process of data transference. The automatic transference was implemented as an Extract, Transform and Load (ETL) process. Then, a comparison was carried out between manual and automatic data collection methods. The criteria to measure data quality were correctness and completeness. The manual process had a general error rate of 2.6% to 7.1%, obtaining the lowest error rate if data fields with a not clear definition were removed from the analysis (p < 10E-3). In the case of automatic process, the general error rate was 1.9% to 12.1%, where lowest error rate is obtained when excluding information missing in the HIS but transcribed to the EDC from other physical sources. The automatic ETL process can be used to collect laboratory data for clinical research if data in the HIS as well as physical documentation not included in HIS, are identified previously and follows a standardized data collection protocol.

  15. Understanding virtual water flows: A multiregion input-output case study of Victoria

    NASA Astrophysics Data System (ADS)

    Lenzen, Manfred

    2009-09-01

    This article explains and interprets virtual water flows from the well-established perspective of input-output analysis. Using a case study of the Australian state of Victoria, it demonstrates that input-output analysis can enumerate virtual water flows without systematic and unknown truncation errors, an issue which has been largely absent from the virtual water literature. Whereas a simplified flow analysis from a producer perspective would portray Victoria as a net virtual water importer, enumerating the water embodiments across the full supply chain using input-output analysis shows Victoria as a significant net virtual water exporter. This study has succeeded in informing government policy in Australia, which is an encouraging sign that input-output analysis will be able to contribute much value to other national and international applications.

  16. Agricultural trade and the global phosphorus cycle

    NASA Astrophysics Data System (ADS)

    Schipanski, M.; Bennett, E.; Riskin, S.; Porder, S.

    2012-12-01

    Trends of increasing agricultural trade, increased concentration of livestock production systems, and increased human consumption of livestock products influence the distribution of nutrients across the global landscape. Phosphorus (P) represents a unique management challenge as we are rapidly depleting mineable reserves of this essential and non-renewable resource. At the same time, its overuse can lead to pollution of aquatic ecosystems. We analyzed the relative contributions of food crop, feed crop, and livestock product trade to P flows through agricultural soils for twelve countries from 1961 to 2007. We then used case studies of P fertilizer use in the world's three major soybean export regions: Iowa (USA), Mato Grosso (Brazil), and Buenos Aires (Argentina) to examine the influence of historical P management and soil types on agriculture's environmental consequences. Due to the intensification of agricultural production, average soil surface P balances more than tripled from 6 to 21 kg P per ha between 1961 and 2007 for the twelve study countries. Consequently, countries that are primarily agricultural exporters carried increased risks for water pollution or, for Argentina, reduced soil fertility due to soil P mining to support exports. In 2007, nations imported food and feed from regions with higher apparent P fertilizer use efficiencies than if those crops were produced domestically. However, this was largely because imports were sourced from regions depleting soil P resources to support export crop production. In addition, the pattern of regional specialization and intensification of production systems also reduced the potential to recycle P resources, with greater implications for livestock production than crop production. In a globalizing world, it will be increasingly important to integrate biophysical constraints of our natural resources and environmental impacts of agricultural systems into trade policy and agreements and to develop mechanisms that move us closer to more equitable management of non-renewable resources such as phosphorus.

  17. Mercury export from the Yukon River Basin and potential response to a changing climate

    USGS Publications Warehouse

    Schuster, P. F.; Striegl, Robert G.; Aiken, G. R.; Krabbenhoft, D. P.; Dewild, J. F.; Butler, K.; Kamark, B.; Dornblaser, M.

    2011-01-01

    We measured mercury (Hg) concentrations and calculated export and yield from the Yukon River Basin (YRB) to quantify Hg flux from a large, permafrost-dominated, high-latitude watershed. Exports of Hg averaged 4400 kg Hg yr–1. The average annual yield for the YRB during the study period was 5.17 μg m–2 yr–1, which is 3–32 times more than Hg yields reported for 8 other major northern hemisphere river basins. The vast majority (90%) of Hg export is associated with particulates. Half of the annual export of Hg occurred during the spring with about 80% of 34 samples exceeding the U.S. EPA Hg standard for adverse chronic effects to biota. Dissolved and particulate organic carbon exports explained 81% and 50%, respectively, of the variance in Hg exports, and both were significantly (p < 0.001) correlated with water discharge. Recent measurements indicate that permafrost contains a substantial reservoir of Hg. Consequently, climate warming will likely accelerate the mobilization of Hg from thawing permafrost increasing the export of organic carbon associated Hg and thus potentially exacerbating the production of bioavailable methylmercury from permafrost-dominated northern river basins.

  18. Mercury export from the Yukon River Basin and potential response to a changing climate

    USGS Publications Warehouse

    Schuster, Paul F.; Striegl, Robert G.; Aiken, George R.; Krabbenhoft, David P.; DeWild, John F.; Butler, Kenna D.; Kamark, Ben; Dornblaser, Mark

    2011-01-01

    We measured mercury (Hg) concentrations and calculated export and yield from the Yukon River Basin (YRB) to quantify Hg flux from a large, permafrost-dominated, high-latitude watershed. Exports of Hg averaged 4400 kg Hg yr-1. The average annual yield for the YRB during the study period was 5.17 μg m-2 yr-1, which is 3–32 times more than Hg yields reported for 8 other major northern hemisphere river basins. The vast majority (90%) of Hg export is associated with particulates. Half of the annual export of Hg occurred during the spring with about 80% of 34 samples exceeding the U.S. EPA Hg standard for adverse chronic effects to biota. Dissolved and particulate organic carbon exports explained 81% and 50%, respectively, of the variance in Hg exports, and both were significantly (p < 0.001) correlated with water discharge. Recent measurements indicate that permafrost contains a substantial reservoir of Hg. Consequently, climate warming will likely accelerate the mobilization of Hg from thawing permafrost increasing the export of organic carbon associated Hg and thus potentially exacerbating the production of bioavailable methylmercury from permafrost-dominated northern river basins.

  19. Non-FG mediated transport of the large pre-ribosomal subunit through the nuclear pore complex by the mRNA export factor Gle2

    PubMed Central

    Occhipinti, Laura; Chang, Yiming; Altvater, Martin; Menet, Anna M.; Kemmler, Stefan; Panse, Vikram G.

    2013-01-01

    Multiple export receptors passage bound pre-ribosomes through nuclear pore complexes (NPCs) by transiently interacting with the Phe-Gly (FG) meshwork of their transport channels. Here, we reveal how the non-FG interacting yeast mRNA export factor Gly-Leu-FG lethal 2 (Gle2) functions in the export of the large pre-ribosomal subunit (pre-60S). Structure-guided studies uncovered conserved platforms used by Gle2 to export pre-60S: an uncharacterized basic patch required to bind pre-60S, and a second surface that makes non-FG contacts with the nucleoporin Nup116. A basic patch mutant of Gle2 is able to function in mRNA export, but not pre-60S export. Thus, Gle2 provides a distinct interaction platform to transport pre-60S to the cytoplasm. Notably, Gle2’s interaction platforms become crucial for pre-60S export when FG-interacting receptors are either not recruited to pre-60S or are impaired. We propose that large complex cargos rely on non-FG as well as FG-interactions for their efficient translocation through the nuclear pore complex channel. PMID:23907389

  20. Heme controls ferroportin1 (FPN1) transcription involving Bach1, Nrf2 and a MARE/ARE sequence motif at position -7007 of the FPN1 promoter.

    PubMed

    Marro, Samuele; Chiabrando, Deborah; Messana, Erika; Stolte, Jens; Turco, Emilia; Tolosano, Emanuela; Muckenthaler, Martina U

    2010-08-01

    Macrophages of the reticuloendothelial system play a key role in recycling iron from hemoglobin of senescent or damaged erythrocytes. Heme oxygenase 1 degrades the heme moiety and releases inorganic iron that is stored in ferritin or exported to the plasma via the iron export protein ferroportin. In the plasma, iron binds to transferrin and is made available for de novo red cell synthesis. The aim of this study was to gain insight into the regulatory mechanisms that control the transcriptional response of iron export protein ferroportin to hemoglobin in macrophages. Iron export protein ferroportin mRNA expression was analyzed in RAW264.7 mouse macrophages in response to hemoglobin, heme, ferric ammonium citrate or protoporphyrin treatment or to siRNA mediated knockdown or overexpression of Btb And Cnc Homology 1 or nuclear accumulation of Nuclear Factor Erythroid 2-like. Iron export protein ferroportin promoter activity was analyzed using reporter constructs that contain specific truncations of the iron export protein ferroportin promoter or mutations in a newly identified MARE/ARE element. We show that iron export protein ferroportin is transcriptionally co-regulated with heme oxygenase 1 by heme, a degradation product of hemoglobin. The protoporphyrin ring of heme is sufficient to increase iron export protein ferroportin transcriptional activity while the iron released from the heme moiety controls iron export protein ferroportin translation involving the IRE in the 5'untranslated region. Transcription of iron export protein ferroportin is inhibited by Btb and Cnc Homology 1 and activated by Nuclear Factor Erythroid 2-like involving a MARE/ARE element located at position -7007/-7016 of the iron export protein ferroportin promoter. This finding suggests that heme controls a macrophage iron recycling regulon involving Btb and Cnc Homology 1 and Nuclear Factor Erythroid 2-like to assure the coordinated degradation of heme by heme oxygenase 1, iron storage and detoxification by ferritin, and iron export by iron export protein ferroportin.

  1. Biogeochemistry of the Penobscot River watershed, Maine, USA: nutrient export patterns for carbon, nitrogen, and phosphorus.

    PubMed

    Cronan, Christopher S

    2012-07-01

    Watershed exports of carbon, nitrogen, phosphorus, major solutes, and suspended sediments were examined during five water years in the Penobscot River basin, which forms part of the Gulf of Maine watershed. Mean annual exports of dissolved organic carbon (DOC) in the Penobscot River were 58 kg C ha(-1) year(-1), whereas cumulative yearly watershed flux of DOC during the study period ranged from 8.6 to 16.1 × 10(10) g C year(-1) and averaged 11.7 × 10(10) g C year(-1). Watershed exports of total soluble N (TN) and total soluble P in the Penobscot River averaged 1.9 and 0.02 kg ha(-1) year(-1), respectively. Companion studies in two other major Maine rivers indicated that mean annual exports of DOC and TN in the Androscoggin River were 40 kg C ha(-1) year(-1) and 2.0 kg N ha(-1) year(-1), whereas exports in the Kennebec River were 43 kg C ha(-1) year(-1) and 2.2 kg N ha(-1) year(-1). Extrapolation of results from this investigation and a previous complementary study indicates that estuaries and coastal waters in the Gulf of Maine receive at least 1.0 × 10(10) g N year(-1) and 2.5 × 10(11) g C year(-1) in combined runoff from the four largest Maine river basins. Soluble exports of Ca + Mg + Na minus wet deposition inputs of cations in the Penobscot system were approximately 1,840 mol(c) ha(-1) year(-1), which represents a minimum estimate of cation denudation from the watershed. Based on its low N and P export rates, the Penobscot River watershed represents an example of reference conditions for use as a benchmark in ecological assessments of river water quality restoration or impairment. In addition, the biogeochemical metrics from this study provide an historical baseline for analysis of future trends in nutrient exports from the Penobscot watershed as a function of changing climatic and land use patterns.

  2. Phosphorus export across an urban to rural gradient in the Chesapeake Bay watershed

    Treesearch

    Shuiwang Duan; Sujay S. Kaushal; Peter Groffman; Lawrence E. Band; Kenneth Belt

    2012-01-01

    Watershed export of phosphorus (P) from anthropogenic sources has contributed to eutrophication in freshwater and coastal ecosystems. We explore impacts of watershed urbanization on the magnitude and export flow distribution of P along an urban-rural gradient in eight watersheds monitored as part of the Baltimore Ecosystem Study Long-Term Ecological Research site....

  3. Long-term dynamics of organic matter and elements exported as coarse particulates from two Caribbean montane watersheds

    Treesearch

    T. Heartsill Scalley; F.N. Scatena; S. Moya; A.E. Lugo

    2012-01-01

    In heterotrophic streams the retention and export of coarse particulate organic matter and associated elements are fundamental biogeochemical processes that influence water quality, food webs and the structural complexity of forested headwater streams. Nevertheless, few studies have documented the quantity and quality of exported organic matter over multiple years and...

  4. Indicators of nitrate export from forested watersheds of the Chesapeake Bay region

    Treesearch

    Karl W. J. Williard

    1997-01-01

    Soil net nitrogen mineralization and nitrification rates were studied on nine relatively undisturbed, forested watersheds in an effort to explain the large variations in nitrate export in streamflow within the Chesapeake Bay region. The primary hypothesis tested was that nitrate export from the watersheds was positively associated with rates of net soil nitrogen...

  5. Analysis of Palm Oil Production, Export, and Government Consumption to Gross Domestic Product of Five Districts in West Kalimantan by Panel Regression

    NASA Astrophysics Data System (ADS)

    Sulistianingsih, E.; Kiftiah, M.; Rosadi, D.; Wahyuni, H.

    2017-04-01

    Gross Domestic Product (GDP) is an indicator of economic growth in a region. GDP is a panel data, which consists of cross-section and time series data. Meanwhile, panel regression is a tool which can be utilised to analyse panel data. There are three models in panel regression, namely Common Effect Model (CEM), Fixed Effect Model (FEM) and Random Effect Model (REM). The models will be chosen based on results of Chow Test, Hausman Test and Lagrange Multiplier Test. This research analyses palm oil about production, export, and government consumption to five district GDP are in West Kalimantan, namely Sanggau, Sintang, Sambas, Ketapang and Bengkayang by panel regression. Based on the results of analyses, it concluded that REM, which adjusted-determination-coefficient is 0,823, is the best model in this case. Also, according to the result, only Export and Government Consumption that influence GDP of the districts.

  6. Virtual water trade and time scales for loss of water sustainability: A comparative regional analysis

    PubMed Central

    Goswami, Prashant; Nishad, Shiv Narayan

    2015-01-01

    Assessment and policy design for sustainability in primary resources like arable land and water need to adopt long-term perspective; even small but persistent effects like net export of water may influence sustainability through irreversible losses. With growing consumption, this virtual water trade has become an important element in the water sustainability of a nation. We estimate and contrast the virtual (embedded) water trades of two populous nations, India and China, to present certain quantitative measures and time scales. Estimates show that export of embedded water alone can lead to loss of water sustainability. With the current rate of net export of water (embedded) in the end products, India is poised to lose its entire available water in less than 1000 years; much shorter time scales are implied in terms of water for production. The two cases contrast and exemplify sustainable and non-sustainable virtual water trade in long term perspective. PMID:25790964

  7. 7 CFR 1493.80 - Evidence of export.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... OF AGRICULTURE EXPORT PROGRAMS CCC EXPORT CREDIT GUARANTEE PROGRAMS CCC Export Credit Guarantee Program (GSM-102) and CCC Intermediate Export Credit Guarantee Program (GSM-103) Operations § 1493.80 Evidence of export. (a) Report of export. The exporter is required to provide CCC an evidence of export...

  8. 7 CFR 1493.80 - Evidence of export.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... OF AGRICULTURE EXPORT PROGRAMS CCC EXPORT CREDIT GUARANTEE PROGRAMS CCC Export Credit Guarantee Program (GSM-102) and CCC Intermediate Export Credit Guarantee Program (GSM-103) Operations § 1493.80 Evidence of export. (a) Report of export. The exporter is required to provide CCC an evidence of export...

  9. 7 CFR 1493.80 - Evidence of export.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... OF AGRICULTURE EXPORT PROGRAMS CCC EXPORT CREDIT GUARANTEE PROGRAMS CCC Export Credit Guarantee Program (GSM-102) and CCC Intermediate Export Credit Guarantee Program (GSM-103) Operations § 1493.80 Evidence of export. (a) Report of export. The exporter is required to provide CCC an evidence of export...

  10. 75 FR 29514 - Export Trade Certificate of Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-26

    ... Operation described below in the following Export Trade and Export Markets: Export Trade Export Product ALCC... being headed and gutted. Export Markets The Export Markets include all parts of the world except the... engage in Export Trade in the Export Markets, ALCC and its Members may undertake the following activities...

  11. 10 CFR 205.261-205.269 - [Reserved

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 3 2014-01-01 2014-01-01 false [Reserved] 205.261-205.269 Section 205.261-205.269 Energy DEPARTMENT OF ENERGY OIL ADMINISTRATIVE PROCEDURES AND SANCTIONS Procedures for Electricity Export Cases §§ 205.261-205.269 [Reserved] ...

  12. 10 CFR 205.261-205.269 - [Reserved

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 3 2013-01-01 2013-01-01 false [Reserved] 205.261-205.269 Section 205.261-205.269 Energy DEPARTMENT OF ENERGY OIL ADMINISTRATIVE PROCEDURES AND SANCTIONS Procedures for Electricity Export Cases §§ 205.261-205.269 [Reserved] ...

  13. 10 CFR 205.261-205.269 - [Reserved

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 3 2011-01-01 2011-01-01 false [Reserved] 205.261-205.269 Section 205.261-205.269 Energy DEPARTMENT OF ENERGY OIL ADMINISTRATIVE PROCEDURES AND SANCTIONS Procedures for Electricity Export Cases §§ 205.261-205.269 [Reserved] ...

  14. 10 CFR 205.261-205.269 - [Reserved

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 3 2010-01-01 2010-01-01 false [Reserved] 205.261-205.269 Section 205.261-205.269 Energy DEPARTMENT OF ENERGY OIL ADMINISTRATIVE PROCEDURES AND SANCTIONS Procedures for Electricity Export Cases §§ 205.261-205.269 [Reserved] ...

  15. 10 CFR 205.261-205.269 - [Reserved

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 3 2012-01-01 2012-01-01 false [Reserved] 205.261-205.269 Section 205.261-205.269 Energy DEPARTMENT OF ENERGY OIL ADMINISTRATIVE PROCEDURES AND SANCTIONS Procedures for Electricity Export Cases §§ 205.261-205.269 [Reserved] ...

  16. RMIT University at TREC 2008: Relevance Feedback Track

    DTIC Science & Technology

    2008-11-01

    extracted . A term was defined as a sequence of alphanumeric characters delimited by whitespace Williams and Zobel (2005). Terms were then case-folded and...lemons* navel* nfc* concentrated* oranges* economic* growers* exporter* juice* crop* grapefruit * fresh* citrus* conditions* september* tangerines

  17. Hybrid Laser/GMAW of High Strength Steel Gas Transmission Pipelines

    DOT National Transportation Integrated Search

    2008-07-01

    Pipelines will be an integral part of our energy distribution systems for the foreseeable future. Operators are currently considering the installation of tens of billions of dollars of pipeline infrastructure. In a number of cases, the cost of export...

  18. Bringing the Firms into Globalization Research: The Effects of Foreign Investment and Exports on Wages in Mexican Manufacturing Firms

    PubMed Central

    Villarreal, Andrés; Sakamoto, Arthur

    2011-01-01

    Researchers specializing in organizations and labor markets have paid insufficient attention to the effects that foreign ownership of a firm and its orientation towards export production may have on the wages it pays to its workers. Using information from a nationally-representative sample of manufacturing firms in Mexico, a paradigmatic case of a developing country that is highly integrated into world markets, we find that foreign-owned and export-oriented firms pay considerably more than nationally-owned firms engaged in the production of goods for sale in the domestic market. Second, beyond paying higher wages to their workers, foreign-owned firms also raise the wages paid by domestic firms operating in the same regional labor markets. The wage premium in foreign and export-oriented firms cannot be explained by their size, industry, geographical location, productivity, use of advanced technology, or the sociodemographic composition of their workforce. We find evidence that wages in foreign-owned companies in Mexico are dependent on the country of origin of the capital investment. A greater difference between the industry-specific wages paid in the country of ownership and Mexico is associated with a higher wage premium in Mexican affiliates. Future work should strive to link information from foreign-owned affiliates with their parent companies abroad. PMID:21566699

  19. Prediction with Pooled Cross-Section and Time-Series Data: Two Case Studies.

    DTIC Science & Technology

    1982-02-01

    1977) 10. It may be that Venezuela’s role as a major oil R. C. Vogel, "The Dynamics of Inflation in Latin exporter makes the inflationary behavior of ...Instablitis." pp 296 24 pp., Dec 2976 (Published In Jawrnal of Cheeical Physics, Mango ), Marc S. end Thomas, Jams A., Jr., ’Analyticai Vol. 69, No. 6...is so dif- to first test for the overall homogeneity (equal- ferent that nothing can be gained by observing ity) of the coefficients. If this

  20. Exporting a Student-Centered Curriculum: A Home Institution’s Perspective

    PubMed Central

    Waterval, Dominique; Tinnemans-Adriaanse, Marjolijn; Meziani, Mohammed; Driessen, Erik; Scherpbier, Albert; Mazrou, Abdulrahman; Frambach, Janneke

    2017-01-01

    Numerous, mainly Anglo-Saxon, higher education institutions have agreements with foreign providers to deliver their curricula abroad. This trend is gradually making inroads into the medical domain, where foreign institutions undertake to offer their students learning experiences similar to those of the home institution. Not an easy feat, as the national health care contexts differ greatly between institutions. In a bid to export the curriculum, institutions risk compromising their financial resilience and reputation. This article presents an instrumental case study of a home institution’s perspective on the establishment of a cross-border student-centered curriculum partnership. It provides the reader with a practical discourse on dimensions that need to be bridged between home and host contexts, and on new working processes that need to be integrated within the home institution’s existing organizational structure. We describe the advantages and disadvantages based on our experiences with a centralized organizational approach, and advocate for a gradual move toward decentral interfaculty communities of practice. PMID:29046607

  1. Exporting a Student-Centered Curriculum: A Home Institution's Perspective.

    PubMed

    Waterval, Dominique; Tinnemans-Adriaanse, Marjolijn; Meziani, Mohammed; Driessen, Erik; Scherpbier, Albert; Mazrou, Abdulrahman; Frambach, Janneke

    2017-07-01

    Numerous, mainly Anglo-Saxon, higher education institutions have agreements with foreign providers to deliver their curricula abroad. This trend is gradually making inroads into the medical domain, where foreign institutions undertake to offer their students learning experiences similar to those of the home institution. Not an easy feat, as the national health care contexts differ greatly between institutions. In a bid to export the curriculum, institutions risk compromising their financial resilience and reputation. This article presents an instrumental case study of a home institution's perspective on the establishment of a cross-border student-centered curriculum partnership. It provides the reader with a practical discourse on dimensions that need to be bridged between home and host contexts, and on new working processes that need to be integrated within the home institution's existing organizational structure. We describe the advantages and disadvantages based on our experiences with a centralized organizational approach, and advocate for a gradual move toward decentral interfaculty communities of practice.

  2. Application of TREECS Modeling System to Strontium-90 for Borschi Watershed near Chernobyl, Ukraine.

    PubMed

    Johnson, Billy E; Dortch, Mark S

    2014-05-01

    The Training Range Environmental Evaluation and Characterization System (TREECS™) (http://el.erdc.usace.army.mil/treecs/) is being developed by the U.S. Army Engineer Research and Development Center (ERDC) for the U.S. Army to forecast the fate of munitions constituents (MC) (such as high explosives (HE) and metals) found on firing/training ranges, as well as those subsequently transported to surface water and groundwater. The overall purpose of TREECS™ is to provide environmental specialists with tools to assess the potential for MC migration into surface water and groundwater systems and to assess range management strategies to ensure protection of human health and the environment. The multimedia fate/transport models within TREECS™ are mathematical models of reduced form (e.g., reduced dimensionality) that allow rapid application with less input data requirements compared with more complicated models. Although TREECS™ was developed for the fate of MC from military ranges, it has general applicability to many other situations requiring prediction of contaminant (including radionuclide) fate in multi-media environmental systems. TREECS™ was applied to the Borschi watershed near the Chernobyl Nuclear Power Plant, Ukraine. At this site, TREECS™ demonstrated its use as a modeling tool to predict the fate of strontium 90 ((90)Sr). The most sensitive and uncertain input for this application was the soil-water partitioning distribution coefficient (Kd) for (90)Sr. The TREECS™ soil model provided reasonable estimates of the surface water export flux of (90)Sr from the Borschi watershed when using a Kd for (90)Sr of 200 L/kg. The computed export for the year 2000 was 0.18% of the watershed inventory of (90)Sr compared to the estimated export flux of 0.14% based on field data collected during 1999-2001. The model indicated that assumptions regarding the form of the inventory, whether dissolved or in solid phase form, did not appreciably affect export rates. Also, the percentage of non-exchangeable adsorbed (90)Sr, which is uncertain and affects the amount of (90)Sr available for export, was fixed at 20% based on field data measurements. A Monte Carlo uncertainty analysis was conducted treating Kd as an uncertain input variable with a range of 100-300 L/kg. This analysis resulted in a range of 0.13-0.27% of inventory exported to surface water compared to 0.14% based on measured field data. Based on this model application, it was concluded that the export of (90)Sr from the Borschi watershed to surface water is predominantly a result of soil pore water containing dissolved (90)Sr being diverted to surface waters that eventually flow out of the watershed. The percentage of non-exchangeable adsorbed (90)Sr and the soil-water Kd are the two most sensitive and uncertain factors affecting the amount of export. The 200-year projections of the model showed an exponential decline in (90)Sr export fluxes from the watershed that should drop by a factor of 10 by the year 2100. This presentation will focus on TREECS capabilities and the case study done for the Borschi Watershed. Published by Elsevier Ltd.

  3. CHD3 facilitates vRNP nuclear export by interacting with NES1 of influenza A virus NS2.

    PubMed

    Hu, Yong; Liu, Xiaokun; Zhang, Anding; Zhou, Hongbo; Liu, Ziduo; Chen, Huanchun; Jin, Meilin

    2015-03-01

    NS2 from influenza A virus mediates Crm1-dependent vRNP nuclear export through interaction with Crm1. However, even though the nuclear export signal 1 (NES1) of NS2 does not play a requisite role in NS2-Crm1 interaction, there is no doubt that NES1 is crucial for vRNP nuclear export. While the mechanism of the NES1 is still unclear, it is speculated that certain host partners might mediate the NES1 function through their interaction with NES1. In the present study, chromodomain-helicase-DNA-binding protein 3 (CHD3) was identified as a novel host nuclear protein for locating NS2 and Crm1 on dense chromatin for NS2 and Crm1-dependent vRNP nuclear export. CHD3 was confirmed to interact with NES1 in NS2, and a disruption to this interaction by mutation in NES1 significantly delayed viral vRNPs export and viral propagation. Further, the knockdown of CHD3 would affect the propagation of the wild-type virus but not the mutant with the weakened NS2-CHD3 interaction. Therefore, this study demonstrates that NES1 is required for maximal binding of NS2 to CHD3, and that the NS2-CHD3 interaction on the dense chromatin contributed to the NS2-mediated vRNP nuclear export.

  4. Amounts, isotopic character, and ages of organic and inorganic carbon exported from rivers to ocean margins: 2. Assessment of natural and anthropogenic controls

    NASA Astrophysics Data System (ADS)

    Hossler, Katie; Bauer, James E.

    2013-04-01

    Riverine exports of carbon (C) and organic matter (OM) are regulated by a variety of natural and anthropogenic factors. Understanding the relationships between these various factors and C and OM exports can help to constrain global C budgets and allow assessment of current and future anthropogenic impacts on both riverine and global C cycles. We quantified the effects of multiple natural and anthropogenic controls on riverine export fluxes and compositions of particulate organic C, dissolved organic C, and dissolved inorganic C for a regional group of eight rivers in the northeastern U.S. Potential controls related to hydrogeomorphology and regional climate, soil order, soil texture, bedrock lithology, land use, and anthropogenic factors were analyzed individually, collectively, and at scales of both local and regional influence. Factors related to hydrogeomorphology and climate, followed in importance by land use and anthropogenic factors, exhibited the strongest impacts on riverine C exports and compositions, particularly at smaller localized scales. The effects of hydrogeomorphology and climate were primarily related to volumetric flow, which resulted in greater exports of terrestrial and total C. Principal anthropogenic factors included impacts of wastewater treatment plants (WWTPs) and river impoundments. The presence of WWTPs as well as anthropogenic use of carbonate-based materials (e.g., limestone) may have substantially increased riverine C exports, particularly fossil C exports, in the study region. The presence of nuclear power plants in the associated watersheds is also discussed because of the potential for anthropogenic 14C inputs and subsequent biasing of aquatic C studies utilizing natural abundance 14C.

  5. Factors that influence the export success of forest products companies in the Pacific Northwest

    Treesearch

    I. Eastin; K. Cunningham; J. Roos

    2004-01-01

    Although most North American firms reported a decline in export revenues from Japan over the period 1997 to 1998, some firms experienced increases. This anomaly prompted an investigation into why some firms were successful in increasing their exports while other firms were not. The primary objective of this study was to identify the key characteristics of successful...

  6. Impacts of extratropical storm tracks on Arctic sea ice export through Fram Strait

    NASA Astrophysics Data System (ADS)

    Wei, Jianfen; Zhang, Xiangdong; Wang, Zhaomin

    2018-05-01

    Studies have indicated regime shifts in atmospheric circulation, and associated changes in extratropical storm tracks and Arctic storm activity, in particular on the North Atlantic side of the Arctic Ocean. To improve understanding of changes in Arctic sea ice mass balance, we examined the impacts of the changed storm tracks and cyclone activity on Arctic sea ice export through Fram Strait by using a high resolution global ocean-sea ice model, MITgcm-ECCO2. The model was forced by the Japanese 25-year Reanalysis (JRA-25) dataset. The results show that storm-induced strong northerly wind stress can cause simultaneous response of daily sea ice export and, in turn, exert cumulative effects on interannual variability and long-term changes of sea ice export. Further analysis indicates that storm impact on sea ice export is spatially dependent. The storms occurring southeast of Fram Strait exhibit the largest impacts. The weakened intensity of winter (in this study winter is defined as October-March and summer as April-September) storms in this region after 1994/95 could be responsible for the decrease of total winter sea ice export during the same time period.

  7. American export control, technology spillover and innovation of Chinese pharmaceutical Industry.

    PubMed

    Hui, Jiang

    2017-05-01

    This paper was aimed to analyze whether the U.S. strict export control to China affects the technological innovation of Chinese pharmaceutical industry. This paper selected the data of technological innovation and the expenditure of high and new technology adoption in China's pharmaceutical industry from 1995 to 2014, created panel regression model to study the impact of export controls on technology spillovers and the impact of technology spillovers on innovation capacity. The results show that US export control has a significant impact on technology spillovers, but foreign technology spillovers have no significant impact on the innovation of Chinese pharmaceutical industry. Although the US export control prevented foreign technology spillovers to China, but indirectly stimulated the domestic technology spillovers to pharmaceutical manufacturing industry in China. Statistical analysis show that the correlation coefficient between innovation capacity and expenditure for high technology adoption is not significant, but the expenditure of purchasing domestic technical is essential to pharmaceutical innovation. This study shows that US export control indirectly, not directly, affected the technological innovation of China's pharmaceutical industry, affected the allocation of innovative resources, but failed to prevent the technological progress and competitiveness improvement of Chinese pharmaceutical industry.

  8. Effect of Increased Levels of Liquefied Natural Gas Exports on U.S. Energy Markets

    EIA Publications

    2014-01-01

    This report responds to a May 29, 2014 request from the U.S. Department of Energy's Office of Fossil Energy (DOE/FE) for an update of the Energy Information Administration's (EIA) January 2012 study of liquefied natural gas (LNG) export scenarios. This updated study, like the prior one, is intended to serve as an input to be considered in the evaluation of applications to export LNG from the United States under Section 3 of the Natural Gas Act, which requires DOE to grant a permit to export domestically produced natural gas unless it finds that such action is not consistent with the public interest. Appendix A provides a copy of the DOE/FE request letter.

  9. Southern California Seismic Network: New Design and Implementation of Redundant and Reliable Real-time Data Acquisition Systems

    NASA Astrophysics Data System (ADS)

    Saleh, T.; Rico, H.; Solanki, K.; Hauksson, E.; Friberg, P.

    2005-12-01

    The Southern California Seismic Network (SCSN) handles more than 2500 high-data rate channels from more than 380 seismic stations distributed across southern California. These data are imported real-time from dataloggers, earthworm hubs, and partner networks. The SCSN also exports data to eight different partner networks. Both the imported and exported data are critical for emergency response and scientific research. Previous data acquisition systems were complex and difficult to operate, because they grew in an ad hoc fashion to meet the increasing needs for distributing real-time waveform data. To maximize reliability and redundancy, we apply best practices methods from computer science for implementing the software and hardware configurations for import, export, and acquisition of real-time seismic data. Our approach makes use of failover software designs, methods for dividing labor diligently amongst the network nodes, and state of the art networking redundancy technologies. To facilitate maintenance and daily operations we seek to provide some separation between major functions such as data import, export, acquisition, archiving, real-time processing, and alarming. As an example, we make waveform import and export functions independent by operating them on separate servers. Similarly, two independent servers provide waveform export, allowing data recipients to implement their own redundancy. The data import is handled differently by using one primary server and a live backup server. These data import servers, run fail-over software that allows automatic role switching in case of failure from primary to shadow. Similar to the classic earthworm design, all the acquired waveform data are broadcast onto a private network, which allows multiple machines to acquire and process the data. As we separate data import and export away from acquisition, we are also working on new approaches to separate real-time processing and rapid reliable archiving of real-time data. Further, improved network security is an integral part of the new design. Redundant firewalls will provide secure data imports, exports, and acquisition as well as DMZ zones for web servers and other publicly available servers. We will present the detailed design of this new configuration that is currently being implemented by the SCSN at Caltech. The design principals are general enough to be of use to most regional seismic networks.

  10. Synthesis of nutrient and sediment export patterns in the Chesapeake Bay watershed: Complex and non-stationary concentration-discharge relationships.

    PubMed

    Zhang, Qian

    2018-03-15

    Derived from river monitoring data, concentration-discharge (C-Q) relationships are useful indicators of riverine export dynamics. A top-down synthesis of C-Q patterns was conducted for suspended sediment (SS), total phosphorus (TP), and total nitrogen (TN) for nine major tributaries (15 monitoring sites) to Chesapeake Bay, which represent diverse characteristics in terms of land use, physiography, and hydrological settings. Model coefficients from the recently-developed Weighted Regressions on Time, Discharge, and Season (WRTDS) method were used to make informative interpretation of C-Q relationships. Unlike many previous C-Q studies that focused on stormflow conditions, this approach allows simultaneous examination of various discharge conditions within an uncertainty framework. This synthesis on WRTDS coefficients (i.e., the sensitivity of concentration to discharge) has offered new insights on the complexity of watershed function. Results show that watershed export has been dominated by mobilization patterns for SS and TP (particulate-dominated species) and chemostasis patterns for TN (dissolved-dominated species) under many river discharge conditions. Among nine possible modalities of low-flow vs. high-flow patterns, the three most frequent modalities are mobilization vs. mobilization (17 cases), chemostasis vs. mobilization (13 cases), and chemostasis vs. chemostasis (7 cases), representing 82% of all 45 watershed-constituent pairs. The general lack of dilution patterns may suggest that none of these constituents has been supply-limited in these watersheds. For many watershed-constituent combinations, results show clear temporal non-stationarity in C-Q relationships under selected time-invariant discharges, reflecting major changes in dominant watershed sources due to anthropogenic actions. These results highlight the potential pitfalls of assuming fixed C-Q relationships in the record. Overall, this work demonstrates the utility of WRTDS model coefficients for interpretation of river water-quality data and for generation of sensible hypotheses on dominant processes in different watersheds. The approach is readily adaptable to other river systems, where long-term discretely-sampled data are available, to decipher complex interactions between hydrological and biogeochemical processes. Copyright © 2017 Elsevier B.V. All rights reserved.

  11. Modelling of the estimated contributions of different sub-watersheds and sources to phosphorous export and loading from the Dongting Lake watershed, China.

    PubMed

    Hou, Ying; Chen, Weiping; Liao, Yuehua; Luo, Yueping

    2017-11-03

    Considerable growth in the economy and population of the Dongting Lake watershed in Southern China has increased phosphorus loading to the lake and resulted in a growing risk of lake eutrophication. This study aimed to reveal the spatial pattern and sources of phosphorus export and loading from the watershed. We applied an export coefficient model and the Dillon-Rigler model to quantify contributions of different sub-watersheds and sources to the total phosphorus (TP) export and loading in 2010. Together, the upper and lower reaches of the Xiang River watershed and the Dongting Lake Area contributed 60.9% of the TP exported from the entire watershed. Livestock husbandry appeared to be the largest anthropogenic source of TP, contributing more than 50% of the TP exported from each secondary sub-watersheds. The actual TP loading to the lake in 2010 was 62.9% more than the permissible annual TP loading for compliance with the Class III water quality standard for lakes. Three primary sub-watersheds-the Dongting Lake Area, the Xiang River, and the Yuan River watersheds-contributed 91.2% of the total TP loading. As the largest contributor among all sources, livestock husbandry contributed nearly 50% of the TP loading from the Dongting Lake Area and more than 60% from each of the other primary sub-watersheds. This study provides a methodology to identify the key sources and locations of TP export and loading in large lake watersheds. The study can provide a reference for the decision-making for controlling P pollution in the Dongting Lake watershed.

  12. Resolving the Intricacies of Lateral Exports of Inorganic Carbon and Alkalinity from Coastal Salt Marshes

    NASA Astrophysics Data System (ADS)

    Wang, A. Z.; Chu, S. N.; Kroeger, K. D.; Gonneea, M. E.; Ganju, N. K.

    2017-12-01

    Dynamic lateral exports of dissolved inorganic carbon (DIC) and total alkalinity (Alk) via tidal exchange from highly productive intertidal marshes are an important piece of puzzle in the coastal carbon cycle, challenging our capability of assessing coastal carbon budgets and projecting future changes under anthropogenic pressure. The effects of these exports on seawater chemistry are profound yet complicated to study. This study presents the latest development of assessing lateral DIC and Alk fluxes from tidal marshes and examining their effects on seawater chemistry and coastal carbon budgets. The study evaluates different approaches to quantify these exports in order to obtain insights on the best and efficient way to capture the dynamics of such exports. A state-of-the-art DIC sensor, Channelized Optical System (CHANOS), was deployed to establish the true DIC fluxes. They are compared to the fluxes derived from empirical modeling and traditional bottle measurements. Salt marshes can acidify and alkalize tidal water by injecting CO2 (DIC) and Alk over a same tidal cycle. However, their generation is decoupled as a result of deferential effects of aerobic and anaerobic respirations. This creates complex scenarios of large swings of seawater chemistry and buffering capacity in tidal water over tidal and seasonal cycles. Marsh exports of DIC and Alk may have complex implications for the future, more acidified ocean. The latest estimates of marsh DIC and Alk exports suggest they are a major term in the marsh carbon budget and can be translated into one of the primary components in the coastal carbon cycle.

  13. Soluble components of the flagellar export apparatus, FliI, FliJ, and FliH, do not deliver flagellin, the major filament protein, from the cytosol to the export gate.

    PubMed

    Sajó, Ráchel; Liliom, Károly; Muskotál, Adél; Klein, Agnes; Závodszky, Péter; Vonderviszt, Ferenc; Dobó, József

    2014-11-01

    Flagella, the locomotion organelles of bacteria, extend from the cytoplasm to the cell exterior. External flagellar proteins are synthesized in the cytoplasm and exported by the flagellar type III secretion system. Soluble components of the flagellar export apparatus, FliI, FliH, and FliJ, have been implicated to carry late export substrates in complex with their cognate chaperones from the cytoplasm to the export gate. The importance of the soluble components in the delivery of the three minor late substrates FlgK, FlgL (hook-filament junction) and FliD (filament-cap) has been convincingly demonstrated, but their role in the transport of the major filament component flagellin (FliC) is still unclear. We have used continuous ATPase activity measurements and quartz crystal microbalance (QCM) studies to characterize interactions between the soluble export components and flagellin or the FliC:FliS substrate-chaperone complex. As controls, interactions between soluble export component pairs were characterized providing Kd values. FliC or FliC:FliS did not influence the ATPase activity of FliI alone or in complex with FliH and/or FliJ suggesting lack of interaction in solution. Immobilized FliI, FliH, or FliJ did not interact with FliC or FliC:FliS detected by QCM. The lack of interaction in the fluid phase between FliC or FliC:FliS and the soluble export components, in particular with the ATPase FliI, suggests that cells use different mechanisms for the export of late minor substrates, and the major substrate, FliC. It seems that the abundantly produced flagellin does not require the assistance of the soluble export components to efficiently reach the export gate. Copyright © 2014 Elsevier B.V. All rights reserved.

  14. An application of seasonal ARIMA models on group commodities to forecast Philippine merchandise exports performance

    NASA Astrophysics Data System (ADS)

    Natividad, Gina May R.; Cawiding, Olive R.; Addawe, Rizavel C.

    2017-11-01

    The increase in the merchandise exports of the country offers information about the Philippines' trading role within the global economy. Merchandise exports statistics are used to monitor the country's overall production that is consumed overseas. This paper investigates the comparison between two models obtained by a) clustering the commodity groups into two based on its proportional contribution to the total exports, and b) treating only the total exports. Different seasonal autoregressive integrated moving average (SARIMA) models were then developed for the clustered commodities and for the total exports based on the monthly merchandise exports of the Philippines from 2011 to 2016. The data set used in this study was retrieved from the Philippine Statistics Authority (PSA) which is the central statistical authority in the country responsible for primary data collection. A test for significance of the difference between means at 0.05 level of significance was then performed on the forecasts produced. The result indicates that there is a significant difference between the mean of the forecasts of the two models. Moreover, upon a comparison of the root mean square error (RMSE) and mean absolute error (MAE) of the models, it was found that the models used for the clustered groups outperform the model for the total exports.

  15. Organic carbon fluxes in the Atlantic and the Southern Ocean: relationship to primary production compiled from satellite radiometer data

    NASA Astrophysics Data System (ADS)

    Fischer, G.; Ratmeyer, V.; Wefer, G.

    Fluxes of organic carbon normalised to a depth of 1000 m from 18 sites in the Atlantic and the Southern Ocean are presented, comprising nine biogeochemical provinces as defined by Longhurst et al. (1995. Journal of Plankton Research 17, 1245-1271). For comparison with primary production, we used a recent compilation of primary production values derived from CZCS data (Antoine et al., 1996. Global Biogeochemical Cycles 10, 57-69). In most cases, the seasonal patterns stood reasonably well in accordance with the carbon fluxes. Particularly, organic carbon flux records from two coastal sites off northwest and southwest Africa displayed a more distinct correlation to the primary production in sectors (1×1°) which are situated closer to the coastal environments. This was primarily caused by large upwelling filaments streaming far offshore, resulting in a cross-shelf carbon transport. With respect to primary production, organic carbon export to a water depth of 1000 m, and the fraction of primary production exported to a depth of 1000 m (export fraction=EF 1000), we were able to distinguish between: (1) the coastal environments with highest values (EF 1000=1.75-2.0%), (2) the eastern equatorial upwelling area with moderately high values (EF 1000=0.8-1.1%), (3) and the subtropical oligotrophic gyres that yielded lowest values (EF 1000=0.6%). Carbon export in the Southern Ocean was low to moderate, and the EF 1000 value seems to be quite low in general. Annual organic carbon fluxes were proportional to primary production, and the export fraction EF 1000 increased with primary production up to 350 gC m -2 yr-1. Latitudinal variations in primary production were reflected in the carbon flux pattern. A high temporal variability of primary production rates and a pronounced seasonality of carbon export were observed in the polar environments, in particular in coastal domains, although primary production (according to Antoine et al., 1996. Global Biogeochemical Cycles 10, 57-69), carbon fluxes, and the export fraction remained at low.

  16. Carbon export in the naturally iron-fertilized Kerguelen area of the Southern Ocean based on the 234Th approach

    NASA Astrophysics Data System (ADS)

    Planchon, F.; Ballas, D.; Cavagna, A.-J.; Bowie, A. R.; Davies, D.; Trull, T.; Laurenceau, E.; Van Der Merwe, P.; Dehairs, F.

    2014-11-01

    The Kerguelen Plateau region in the Indian sector of the Southern Ocean supports annually a large-scale phytoplankton bloom which is naturally fertilized with iron. As part of the second KErguelen Ocean and Plateau compared Study expedition (KEOPS2) in austral spring (October-November 2011), we examined upper-ocean Particulate Organic Carbon (POC) export using the 234Th approach. We aimed at characterizing the spatial and the temporal variability of POC export production at high productivity sites over and downstream the Kerguelen plateau. Export production is compared to a High Nutrient Low Chlorophyll area upstream of the plateau in order to assess the impact of iron-induced productivity on the vertical export of carbon. Deficits in 234Th activities relative to its parent nuclide 238U were observed at all stations in surface waters, indicating that scavenging by particles occurred during the early stages of the phytoplankton bloom. 234Th export was lowest at reference station R-2 (412 ± 134 dpm m-2 d-1) and highest inside a~permanent meander of the Polar Front (PF) at stations E (1995 ± 176 dpm m-2 d-1, second visit E-3) where a detailed time series was obtained as part of a~pseudo-lagrangian study. 234Th export over the central plateau was relatively limited at station A3 early (776 ± 171 dpm m-2 d-1, first visit A3-1) and late in the survey (993 ± 223 dpm m-2 d-1, second visit A3-2), but it was higher at high biomass stations TNS-8 (1372 ± 255 dpm m-2 d-1) and E-4W (1068 ± 208 dpm m-2 d-1) in waters which could be considered as derived from plateau. Limited 234Th export of 973 ± 207 dpm m-2 d-1 was also found in the northern branch of the Kerguelen bloom located downstream of the island, north of the PF (station F-L). The 234Th results support that Fe fertilization increased particle export in all iron fertilized waters. The impact was greatest in the recirculation feature (3-4 fold at 200 m depth), but more moderate over the central Kerguelen plateau and in the northern plume of the Kerguelen bloom (∼2-fold at 200 m depth). The C : Th ratio of large (> 53 μm) potentially sinking particles collected via sequential filtration using in situ pumping (ISP) systems were used to convert the 234Th flux into a POC export flux. The C : Th ratios of sinking particles were highly variable (range: 3.1 ± 0.1-10.5 ± 0.2 μmol dpm-1) with no clear site related trend, despite the variety of ecosystem responses in the fertilized regions. C : Th ratios showed a decreasing trend between 100 and 200 m depth suggesting preferential loss of carbon relative to 234Th possibly due to heterotrophic degradation and/or grazing activity. Comparison of the C : Th ratios within sinking particles obtained with the drifting sediment traps showed in most cases very good agreement to those collected via ISP deployments (> 53 μm particles). Carbon export production varied between 3.5 ± 0.9 mmol m-2 d-1 and 11.8 ± 1.3 mmol m-2 d-1 from the upper 100 m and between 1.8 ± 0.9 mmol m-2 d-1 and 8.2 ± 0.9 mmol m-2 d-1 from the upper 200 m. Highest export production was found inside the PF meander with a range of 5.4 ± 0.7 mmol m-2 d-1 to 11.8 ± 1.1 mmol m-2 d-1 at 100 m depth decreasing to 5.3 ± 1.0 mmol m-2 d-1 to 8.2 ± 0.8 mmol m-2 d-1 at 200 m depth over the 19 day survey period. The impact of Fe fertilization is highest inside the PF meander with 2.9- up to 4.5-fold higher carbon flux at 200 m depth in comparison to the HNLC control station. The impact of Fe fertilization was significantly less over the central plateau (stations A3 and E-4W) and in the northern branch of the bloom (station F-L) with 1.6- up to 2.0-fold higher carbon flux compared to the reference station R. Export efficiencies (ratio of export to primary production) were particularly variable with relatively high values in the recirculation feature (6-27%) and low values (1-5%) over the central plateau (station A3) and north of the PF (station F-L) indicating spring biomass accumulation. Comparison with KEOPS1 results indicated that carbon export production is much lower during the onset of the bloom in austral spring in comparison to the peak and declining phase in late summer.

  17. The role of the subtropical North Atlantic water cycle in recent US extreme precipitation events

    NASA Astrophysics Data System (ADS)

    Li, Laifang; Schmitt, Raymond W.; Ummenhofer, Caroline C.

    2018-02-01

    The role of the oceanic water cycle in the record-breaking 2015 warm-season precipitation in the US is analyzed. The extreme precipitation started in the Southern US in the spring and propagated northward to the Midwest and the Great Lakes in the summer of 2015. This seasonal evolution of precipitation anomalies represents a typical mode of variability of US warm-season precipitation. Analysis of the atmospheric moisture flux suggests that such a rainfall mode is associated with moisture export from the subtropical North Atlantic. In the spring, excessive precipitation in the Southern US is attributable to increased moisture flux from the northwestern portion of the subtropical North Atlantic. The North Atlantic moisture flux interacts with local soil moisture which enables the US Midwest to draw more moisture from the Gulf of Mexico in the summer. Further analysis shows that the relationship between the rainfall mode and the North Atlantic water cycle has become more significant in recent decades, indicating an increased likelihood of extremes like the 2015 case. Indeed, two record-high warm-season precipitation events, the 1993 and 2008 cases, both occurred in the more recent decades of the 66 year analysis period. The export of water from the North Atlantic leaves a marked surface salinity signature. The salinity signature appeared in the spring preceding all three extreme precipitation events analyzed in this study, i.e. a saltier-than-normal subtropical North Atlantic in spring followed by extreme Midwest precipitation in summer. Compared to the various sea surface temperature anomaly patterns among the 1993, 2008, and 2015 cases, the spatial distribution of salinity anomalies was much more consistent during these extreme flood years. Thus, our study suggests that preseason salinity patterns can be used for improved seasonal prediction of extreme precipitation in the Midwest.

  18. Bovine cysticercosis in slaughtered cattle as an indicator of Good Agricultural Practices (GAP) and epidemiological risk factors.

    PubMed

    Rossi, Gabriel Augusto Marques; Hoppe, Estevam Guilherme Lux; Mathias, Luis Antonio; Martins, Ana Maria Centola Vidal; Mussi, Leila Aparecida; Prata, Luiz Francisco

    2015-03-01

    This study focused on estimating the economic losses resulting from cysticercosis at beef cattle farms that supply an export slaughterhouse located in the state of São Paulo, Brazil, and to identify the epidemiological risks factors involved in the disease to ascertain if these farms adopt Good Agricultural Practices (GAP). To this, we used data recorded in 2012 by Brazil's Federal Inspection Service (SIF) on the daily occurrence of the disease, according to the farm from which the animals originated. In addition, the associated risk factors were determined based on a case-control study at 48 farms. Cysticercosis was detected in 2.26% (95% CI 2.2-2.33) of the 190,903 bovines supplied by 556 farms in the following four states: 2.92% (95% CI 2.83-3.03) in São Paulo, 1.81% (95% CI 1.71-1.93) in Minas Gerais, 0.71% (95% CI 0.6-0.82) in Goiás and 1.11% (95% CI 0.79-1.57) in Mato Grosso do Sul, with significant differences in the epidemiological indices of these states. Cysticercosis was detected at 58.45% (95% CI 54.36-62.55) of the farms of this study, representing estimated economic losses of US$312,194.52 for the farmers. Lower prevalence of this disease were found at the farms qualified for exports to the European Union, indicating a statistically significant difference from those not qualified to export to Europe. The access of cattle to non-controlled water sources, as well as sport fishing activities near the farms, was identified as risk factors. Cysticercosis causes considerable losses in Brazil's beef supply chain, with lower prevalence appearing only at farms qualified to export to the European Union. As for the access of cattle to non-controlled water sources, this is an indication that GAP are not implemented by some farms, demonstrating the violation of international agreements by the industry and the farms. Copyright © 2015 Elsevier B.V. All rights reserved.

  19. Integrating rapid risk mapping and mobile phone call record data for strategic malaria elimination planning.

    PubMed

    Tatem, Andrew J; Huang, Zhuojie; Narib, Clothilde; Kumar, Udayan; Kandula, Deepika; Pindolia, Deepa K; Smith, David L; Cohen, Justin M; Graupe, Bonita; Uusiku, Petrina; Lourenço, Christopher

    2014-02-10

    As successful malaria control programmes re-orientate towards elimination, the identification of transmission foci, targeting of attack measures to high-risk areas and management of importation risk become high priorities. When resources are limited and transmission is varying seasonally, approaches that can rapidly prioritize areas for surveillance and control can be valuable, and the most appropriate attack measure for a particular location is likely to differ depending on whether it exports or imports malaria infections. Here, using the example of Namibia, a method for targeting of interventions using surveillance data, satellite imagery, and mobile phone call records to support elimination planning is described. One year of aggregated movement patterns for over a million people across Namibia are analyzed, and linked with case-based risk maps built on satellite imagery. By combining case-data and movement, the way human population movements connect transmission risk areas is demonstrated. Communities that were strongly connected by relatively higher levels of movement were then identified, and net export and import of travellers and infection risks by region were quantified. These maps can aid the design of targeted interventions to maximally reduce the number of cases exported to other regions while employing appropriate interventions to manage risk in places that import them. The approaches presented can be rapidly updated and used to identify where active surveillance for both local and imported cases should be increased, which regions would benefit from coordinating efforts, and how spatially progressive elimination plans can be designed. With improvements in surveillance systems linked to improved diagnosis of malaria, detailed satellite imagery being readily available and mobile phone usage data continually being collected by network providers, the potential exists to make operational use of such valuable, complimentary and contemporary datasets on an ongoing basis in infectious disease control and elimination.

  20. Integrating rapid risk mapping and mobile phone call record data for strategic malaria elimination planning

    PubMed Central

    2014-01-01

    Background As successful malaria control programmes re-orientate towards elimination, the identification of transmission foci, targeting of attack measures to high-risk areas and management of importation risk become high priorities. When resources are limited and transmission is varying seasonally, approaches that can rapidly prioritize areas for surveillance and control can be valuable, and the most appropriate attack measure for a particular location is likely to differ depending on whether it exports or imports malaria infections. Methods/Results Here, using the example of Namibia, a method for targeting of interventions using surveillance data, satellite imagery, and mobile phone call records to support elimination planning is described. One year of aggregated movement patterns for over a million people across Namibia are analyzed, and linked with case-based risk maps built on satellite imagery. By combining case-data and movement, the way human population movements connect transmission risk areas is demonstrated. Communities that were strongly connected by relatively higher levels of movement were then identified, and net export and import of travellers and infection risks by region were quantified. These maps can aid the design of targeted interventions to maximally reduce the number of cases exported to other regions while employing appropriate interventions to manage risk in places that import them. Conclusions The approaches presented can be rapidly updated and used to identify where active surveillance for both local and imported cases should be increased, which regions would benefit from coordinating efforts, and how spatially progressive elimination plans can be designed. With improvements in surveillance systems linked to improved diagnosis of malaria, detailed satellite imagery being readily available and mobile phone usage data continually being collected by network providers, the potential exists to make operational use of such valuable, complimentary and contemporary datasets on an ongoing basis in infectious disease control and elimination. PMID:24512144

  1. Protein engineering of Saccharomyces cerevisiae transporter Pdr5p identifies key residues that impact Fusarium mycotoxin export and resistance to inhibition.

    PubMed

    Gunter, Amanda B; Hermans, Anne; Bosnich, Whynn; Johnson, Douglas A; Harris, Linda J; Gleddie, Steve

    2016-12-01

    Cereal infection by the broad host range fungal pathogen Fusarium graminearum is a significant global agricultural and food safety issue due to the deposition of mycotoxins within infected grains. Methods to study the intracellular effects of mycotoxins often use the baker's yeast model system (Saccharomyces cerevisiae); however, this organism has an efficient drug export network known as the pleiotropic drug resistance (PDR) network, which consists of a family of multidrug exporters. This study describes the first study that has evaluated the potential involvement of all known or putative ATP-binding cassette (ABC) transporters from the PDR network in exporting the F. graminearum trichothecene mycotoxins deoxynivalenol (DON) and 15-acetyl-deoxynivalenol (15A-DON) from living yeast cells. We found that Pdr5p appears to be the only transporter from the PDR network capable of exporting these mycotoxins. We engineered mutants of Pdr5p at two sites previously identified as important in determining substrate specificity and inhibitor susceptibility. These results indicate that it is possible to alter inhibitor insensitivity while maintaining the ability of Pdr5p to export the mycotoxins DON and 15A-DON, which may enable the development of resistance strategies to generate more Fusarium-tolerant crop plants. © 2016 Her Majesty the Queen in Right of Canada. MicrobiologyOpen published by John Wiley & Sons Ltd.

  2. Nuclear export of human hepatitis B virus core protein and pregenomic RNA depends on the cellular NXF1-p15 machinery.

    PubMed

    Yang, Ching-Chun; Huang, Er-Yi; Li, Hung-Cheng; Su, Pei-Yi; Shih, Chiaho

    2014-01-01

    Hepatitis B virus (HBV) core protein (HBc) can shuttle between nucleus and cytoplasm. Cytoplasm-predominant HBc is clinically associated with severe liver inflammation. Previously, we found that HBc arginine-rich domain (ARD) can associate with a host factor NXF1 (TAP) by coimmunoprecipitation. It is well known that NXF1-p15 heterodimer can serve as a major export receptor of nuclear mRNA as a ribonucleoprotein complex (RNP). In the NXF1-p15 pathway, TREX (transcription/export) complex plays an important role in coupling nuclear pre-mRNA processing with mRNA export in mammalian cells. Here, we tested the hypothesis whether HBc and HBV specific RNA can be exported via the TREX and NXF1-p15 mediated pathway. We demonstrated here that HBc can physically and specifically associate with TREX components, and the NXF1-p15 export receptor by coimmunoprecipitation. Accumulation of HBc protein in the nucleus can be induced by the interference with TREX and NXF1-p15 mediated RNA export machinery. HBV transcripts encodes a non-spliced 3.5 kb pregenomic RNA (pgRNA) which can serve as a template for reverse transcription. Cytoplasmic HBV pgRNA appeared to be reduced by siRNA treatment specific for the NXF1-p15 complex by quantitative RT-qPCR and Northern blot analyses. This result suggests that the pgRNA was also exported via the NXF1-p15 machinery. We entertain the hypothesis that HBc protein can be exported as an RNP cargo via the mRNA export pathway by hijacking the TREX and NXF1-p15 complex. In our current and previous studies, HBc is not required for pgRNA accumulation in the cytoplasm. Furthermore, HBc ARD can mediate nuclear export of a chimeric protein containing HBc ARD in a pgRNA-independent manner. Taken together, it suggests that while both pgRNA and HBc protein exports are dependent on NXF1-p15, they are using the same export machinery in a manner independent of each other.

  3. Role of the mRNA export factor Sus1 in oxidative stress tolerance in Candida albicans.

    PubMed

    Xiao, Chenpeng; Yu, Qilin; Zhang, Bing; Li, Jianrong; Zhang, Dan; Li, Mingchun

    2018-02-05

    In eukaryotes, the nuclear export of mRNAs is essential for gene expression. However, little is known about the role of mRNA nuclear export in the important fungal pathogen, Candida albicans. In this study, we identified C. albicans Sus1, a nucleus-localized protein that is required for mRNA export. Interestingly, the sus1Δ/Δ displayed hyper-sensitivity to extracellular oxidative stress, enhanced ROS accumulation and severe oxidative stress-related cell death. More strikingly, although the mutant exhibited normal activation of the expression of oxidative stress response (OSR) genes, it had attenuated activity of ROS scavenging system, which may be attributed to the defect in OSR mRNA export in this mutant. In addition, the virulence of the sus1Δ/Δ was seriously attenuated. Taken together, our findings provide evidence that the mRNA export factor Sus1 plays an important role in oxidative stress tolerance and pathogenesis. Copyright © 2018 Elsevier Inc. All rights reserved.

  4. [Research on ginseng trade competitiveness between China and Korea].

    PubMed

    Xin, Min-Tong; Yang, Guang; Tang, Xiao-Jing

    2017-05-01

    Ginseng is one of China's valuable Chinese herbal medicines, with a long using history. Ginseng has worldwide reputation, and widely used in food, medicine, health products, cosmetics and other production. China and South Korea have a big ginseng industrial, and sharing half of the export market. The ginseng export competitiveness analysis seems important and necessary between China and South Korea. In this paper, the data of customs and trade of ginseng in COMTRADE database were studied, and ginseng export competitiveness was analyzed between China and Korea. The results showed that the ginseng export competitiveness of Korean more competitive than China. Contrast with China, South Korea using only 15% total amount of ginseng exports and produced the same total export amount. This article has the reference value to the traditional Chinese medicine resources management and the economics research. On this basis, this paper further discusses the problems that should be paid attention to in the development of ginseng industry in China. Copyright© by the Chinese Pharmaceutical Association.

  5. 7 CFR 1.123 - Specific exemptions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Meat and Poultry Inspection Program—Slaughter, Processing and Allied Industries Compliance Records... Department pursuant to the Plant Variety Protection Act, the Federal Seed Act, or the Agricultural Marketing... Naval Stores Act, or the Tobacco Seed and Plant Exportation Act, USDA/OGC-29. Court cases brought by the...

  6. 7 CFR 1.123 - Specific exemptions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Meat and Poultry Inspection Program—Slaughter, Processing and Allied Industries Compliance Records... Department pursuant to the Plant Variety Protection Act, the Federal Seed Act, or the Agricultural Marketing... Naval Stores Act, or the Tobacco Seed and Plant Exportation Act, USDA/OGC-29. Court cases brought by the...

  7. 7 CFR 1.123 - Specific exemptions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Meat and Poultry Inspection Program—Slaughter, Processing and Allied Industries Compliance Records... Department pursuant to the Plant Variety Protection Act, the Federal Seed Act, or the Agricultural Marketing... Naval Stores Act, or the Tobacco Seed and Plant Exportation Act, USDA/OGC-29. Court cases brought by the...

  8. 7 CFR 1.123 - Specific exemptions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Meat and Poultry Inspection Program—Slaughter, Processing and Allied Industries Compliance Records... Department pursuant to the Plant Variety Protection Act, the Federal Seed Act, or the Agricultural Marketing... Naval Stores Act, or the Tobacco Seed and Plant Exportation Act, USDA/OGC-29. Court cases brought by the...

  9. 7 CFR 1.123 - Specific exemptions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Meat and Poultry Inspection Program—Slaughter, Processing and Allied Industries Compliance Records... Department pursuant to the Plant Variety Protection Act, the Federal Seed Act, or the Agricultural Marketing... Naval Stores Act, or the Tobacco Seed and Plant Exportation Act, USDA/OGC-29. Court cases brought by the...

  10. 19 CFR 207.24 - Hearing.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... EXPORTS TO THE UNITED STATES Final Determinations, Short Life Cycle Products § 207.24 Hearing. (a) In... closed, presentations at the hearing shall not include business proprietary information. Notwithstanding... the Secretary no later than three (3) business days before the hearing. In the case of testimony to be...

  11. The ins and outs of nuclear re-export of retrogradely transported tRNAs in Saccharomyces cerevisiae

    PubMed Central

    Pierce, Jacqueline B; Eswara, Manoja BK

    2010-01-01

    In Saccharomyces cerevisiae intron-containing pre-tRNAs are exported from the nucleus to the cytoplasm for removal of the introns, and the spliced tRNAs are returned to the nucleus for reasons that are not understood. The re-imported spliced tRNAs are then subjected to aminoacylation in the nucleolus to ensure that they are functional prior to re-export to the cytoplasm. Previous studies have shown that re-imported spliced tRNAs and mature tRNAs made entirely in the nucleus from intronless precursors are retained in the nucleus of S. cerevisiae in response to glucose, amino acid, nitrogen or inorganic phosphate deprivation. Contrary to these studies, we recently reported that starvation of S. cerevisiae of amino acids or nitrogen results in nuclear accumulation of re-imported spliced tRNAs, but not tRNAs made from intronless precursors. This finding suggests that separate pathways are used for nuclear export of retrogradely transported spliced tRNAs and tRNAs made from intronless pre-tRNAs. In addition, the data support the conclusion that the nuclear re-export pathway for retrogradely transported spliced tRNAs, but not the pathway responsible for nuclear export of tRNAs derived from intronless precursors is regulated during amino acid or nitrogen starvation. This regulation appears to occur at a step after the re-imported spliced tRNAs have undergone aminoacylation quality assurance and, in part, involves the TORC1 signalling pathway. Moreover, it was established that Utp9p is an intranuclear component that only facilitates nuclear re-export of retrogradely transported spliced tRNAs by the β-karyopherin Msn5p. Utp9p acts in concert with Utp8p, a key player in nuclear tRNA export in S. cerevisiae, to translocate aminoacylated re-imported spliced tRNAs from the nucleolus to Msn5p and assist with formation of the Msn5p-tRNA-Gsp1p-GTP export complex. This pathway, however, is not the only one responsible for nuclear re-export of retrogradely transported spliced tRNAs. PMID:21327067

  12. Giant landslide deposits and the modalities of their removal by fluvial sediment export in the central Himalayas

    NASA Astrophysics Data System (ADS)

    Lave, Jerome; Lénard, Sébastien; Lanord, Christian France

    2017-04-01

    Slope failures and deep seated landslides are usually considered as the most efficient processes for hillslope erosion in active orogens. Erosion in the Narayani basin in central Himalaya (Nepal) confirms such assertion, with in addition the probable predominance of the very large landslides in the erosive budget of the range. In the High Himalayan part of this basin, a number of pluri-kilometric giant landslides have been described and involve up to ten cubic kilometres mass wasting (e.g. Weidinger et al., 2002). In this contribution, we discuss how the fluvial network do respond to such massive and sudden supply of debris, basing our analysis on several cases, documented by sedimentologic and geomorphologic observations, lithologic counting, geochemical tracing (down to the Ganga plain), and 14C or CRN dating. We first demonstrate that several massive fill terraces preserved along the Lesser Himalayan intramontane reaches are not climatically induced, but rather represent transient storage following giant landslide material export. Two types of deposits and therefore of sediment export modalities have been identified: either (1), as observed along a 100km long stretch of the Marsyandi river, through massive debris flow(s) runout following the break of a landslide-induced dam on main rivers, or (2) by the more gradual but efficient fluvial removal of the giant landslide deposits. In the second case, in particular when bedrock fracturing and crushing during landslide fall has strongly reduced the average debris size, because the steep Himalayan rivers are usually in strong over capacity or largely underloaded with fine to medium-size sediment, their can carry up to several cubic kilometres of sediments in one or two centuries. The coarsest part of the exported material is temporarily stored through aggradation in the massive Lesser Himalayan fill terraces because river gradient drops suddenly when river exits the High Himalaya, whereas the finest fraction is exported very rapidly further downstream, outside of the range. Once a large portion of the landslide debris has been eroded in the source deposit, river quickly returns to over-capacity conditions and to its long term or background conditions, and fill terraces are rapidly re-incised (re-erosion of the fill terrace occurs at rates incommensurate with long term bedrock downcutting rate). The documented Himalayan examples illustrate that erosion of giant landslides deposits can overwhelm the sediment export of a river as large as the Narayani (A=30000km2; average sediment export=150Mt/yr) during several centuries, but that the landscape quickly (i.e. in a similar amount of time) recovers and returns to some long-term average state. The long term influence of these events on the morphology of the fluvial network remains therefore moderate, if we except the persistence of fill terraces remnants in the Lesser Himalaya for several tens of kyr.

  13. Quantifying the surface subsurface biogeochemical coupling during the VERTIGO ALOHA and K2 studies

    NASA Astrophysics Data System (ADS)

    Boyd, Philip W.; Gall, Mark P.; Silver, Mary W.; Coale, Susan L.; Bidigare, Robert R.; Bishop, James L. K. B.

    2008-07-01

    A central question addressed by the VERtical Transport In the Global Ocean (VERTIGO) study was 'What controls the efficiency of particle export between the surface and subsurface ocean'? Here, we present data from sites at ALOHA (N Central Pacific Gyre) and K2 (NW subarctic Pacific) on phytoplankton processes, and relate them via a simple planktonic foodweb model, to subsurface particle export (150-500 m). Three key factors enable quantification of the surface-subsurface coupling: a sampling design to overcome the temporal lag and spatial displacement between surface and subsurface processes; data on the size partitioning of net primary production (NPP) and subsequent transformations prior to export; estimates of the ratio of algal- to faecal-mediated vertical export flux. At ALOHA, phytoplankton were characterized by low stocks, NPP, Fv/ Fm (N-limited), and were dominated by picoplankton. The HNLC waters at K2 were characterized by both two-fold changes in NPP and floristic shifts (high to low proportion of diatoms) between deployment 1 and 2. Prediction of export exiting the euphotic zone was based on size partitioning of NPP, a copepod-dominated foodweb and a ratio of 0.2 (ALOHA) and 0.1 (K2) for algal:faecal particle flux. Predicted export was 20-22 mg POC m -2 d -1 at ALOHA (i.e. 10-11% NPP (0-125 m); 1.1-1.2×export flux at 150 m ( E150). At K2, export was 111 mg C m -2 d -1 (21% NPP (0-50 m); 1.8× E150) and 33 mg POC m -2 d -1 (11% NPP, 0-55 m); 1.4× E150) for deployments 1 and 2, respectively. This decrease in predicted export at K2 matches the observed trend for E150. Also, the low attenuation of export flux from 60 to 150 m is consistent with that between 150 and 500 m. This strong surface-subsurface coupling suggests that phytoplankton productivity and floristics play a key role at K2 in setting export flux, and moreover that pelagic particle transformations by grazers strongly influence to what extent sinking particles are further broken down in the underlying waters of the Twilight Zone.

  14. Dissolved organic carbon export and its contribution to the carbon budget in a boreal peat landscape undergoing rapid permafrost thaw

    NASA Astrophysics Data System (ADS)

    Sonnentag, O.; Fouche, J.; Helbig, M.; Karoline, W.; Hould Gosselin, G.; Hanisch, J.; Quinton, W. L.; Moore, T. R.

    2017-12-01

    Northern permafrost soils store 1035 ± 150 Pg of organic carbon in the first 3 m. In boreal lowlands with warm and thin isolated, sporadic and discontinuous permafrost, increasing temperatures cause a thaw-induced expansion of permafrost-free wetlands at the expense of forested permafrost peat plateaus. Permafrost thaw associated with warmer soils may enhance microbial decomposition of near-surface and deeper organic matter but also increase dissolved organic carbon (DOC) export to aquatic systems. Recent studies suggest that, under a warmer climate, the current net CO2 sink strength of boreal peat landscapes may decline over the next few decades, eventually turning them into net CO2 sources. DOC export from these organic-rich landscapes undergoing rapid permafrost thaw may play a non-negligible role for the carbon budget in a warmer climate. In this study, we quantify the DOC export from a boreal peat landscape in the southern Northwest Territories (Canada). We use half-hourly discharge measurements and DOC concentrations sampled at the outlets of three small catchments ( 0.1 km2) to quantify runoff and DOC export from April to August 2014, 2015 and 2016. We estimate the DOC export contribution to the overall carbon budget using concurrent eddy covariance measurements of net CO2 and methane exchanges. The primary control of DOC export is discharge. In 2016, 70% of the DOC was exported during the two weeks of the spring freshet in early May. DOC export from the three catchments was 3g C m-2 from April to August, which accounted for 15% of the annual net ecosystem exchange. For the same period, the cumulative methane emissions were 6 g C-CH4 m-2. Our findings suggest that thawing boreal peat landscapes along the southern limit of permafrost currently act as net carbon sinks with 11 g C m-2 y-1. Investigating the optical properties of the dissolved organic matter across the different landforms (e.g., transition between forested permafrost peat plateau and permafrost-free wetland) will allow us to assess the different contributions to catchment DOC export and better forecast the changes in DOC lability with permafrost thaw and wetland expansion. Associated with a more rainfall-controlled runoff regime, changes in DOC export with warming may affect the carbon budget in the southern boundaries of the permafrost region.

  15. 7 CFR 1493.470 - Evidence of export.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... OF AGRICULTURE EXPORT PROGRAMS CCC EXPORT CREDIT GUARANTEE PROGRAMS CCC Supplier Credit Guarantee... provide CCC an evidence of export report for each shipment made under the payment guarantee. This report... participation in any of the following CCC or USDA export program: Export Enhancement Program, Dairy Export...

  16. 7 CFR 1493.470 - Evidence of export.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... OF AGRICULTURE EXPORT PROGRAMS CCC EXPORT CREDIT GUARANTEE PROGRAMS CCC Supplier Credit Guarantee... provide CCC an evidence of export report for each shipment made under the payment guarantee. This report... participation in any of the following CCC or USDA export program: Export Enhancement Program, Dairy Export...

  17. 7 CFR 1493.470 - Evidence of export.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... OF AGRICULTURE EXPORT PROGRAMS CCC EXPORT CREDIT GUARANTEE PROGRAMS CCC Supplier Credit Guarantee... provide CCC an evidence of export report for each shipment made under the payment guarantee. This report... participation in any of the following CCC or USDA export program: Export Enhancement Program, Dairy Export...

  18. Effect of the unfolded protein response on ER protein export: a potential new mechanism to relieve ER stress.

    PubMed

    Shaheen, Alaa

    2018-05-05

    The unfolded protein response (UPR) is an adaptive cellular response that aims to relieve endoplasmic reticulum (ER) stress via several mechanisms, including inhibition of protein synthesis and enhancement of protein folding and degradation. There is a controversy over the effect of the UPR on ER protein export. While some investigators suggested that ER export is inhibited during ER stress, others suggested the opposite. In this article, their conflicting studies are analyzed and compared in attempt to solve this controversy. The UPR appears indeed to enhance ER export, possibly via multiple mechanisms. However, another factor, which is the integrity of the folding machinery/environment inside ER, determines whether ER export will appear increased or decreased during experimentation. Also, different methods of stress induction appear to have different effects on ER export. Thus, improvement of ER export may represent a new mechanism by which the UPR alleviates ER stress. This may help researchers to understand how the UPR works inside cells and how to manipulate it to alter cell fate during stress, either to promote cell survival or death. This may open up new approaches for the treatment of ER stress-related diseases.

  19. Hierarchical time series bottom-up approach for forecast the export value in Central Java

    NASA Astrophysics Data System (ADS)

    Mahkya, D. A.; Ulama, B. S.; Suhartono

    2017-10-01

    The purpose of this study is Getting the best modeling and predicting the export value of Central Java using a Hierarchical Time Series. The export value is one variable injection in the economy of a country, meaning that if the export value of the country increases, the country’s economy will increase even more. Therefore, it is necessary appropriate modeling to predict the export value especially in Central Java. Export Value in Central Java are grouped into 21 commodities with each commodity has a different pattern. One approach that can be used time series is a hierarchical approach. Hierarchical Time Series is used Buttom-up. To Forecast the individual series at all levels using Autoregressive Integrated Moving Average (ARIMA), Radial Basis Function Neural Network (RBFNN), and Hybrid ARIMA-RBFNN. For the selection of the best models used Symmetric Mean Absolute Percentage Error (sMAPE). Results of the analysis showed that for the Export Value of Central Java, Bottom-up approach with Hybrid ARIMA-RBFNN modeling can be used for long-term predictions. As for the short and medium-term predictions, it can be used a bottom-up approach RBFNN modeling. Overall bottom-up approach with RBFNN modeling give the best result.

  20. Export of carbon from chloroplasts at night

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Schleucher, J.; Vanderveer, P.J.; Sharkey, T.D.

    Hexose export from chloroplasts at night has been inferred in previous studies of mutant and transgenic plants. The authors have tested whether hexose export is the normal route of carbon export from chloroplasts at night. The authors used nuclear magnetic resonance to distinguish glucose (Glc) made from hexose export and Glc made from triose export. Glc synthesized in vitro from fructose-6-phosphate in the presence of deuterium-labeled water had deuterium incorporated at C-2, whereas synthesis from triose phosphates caused C-2 through C-5 to become deuterated. In both tomato (Lycopersicon esculentum L.) and bean (phaseolus vulgaris L.), Glc from sucrose made atmore » night in the presence of deuterium-enriched water was deuterated only in the C-2 position, indicating that >75% of carbon is exported as hexoses at night. In darkness the phosphate in the cytosol was 28 mM, whereas that in the chloroplasts was 5 mW, but hexose phosphates were 10-fold higher in the cytosol than in the chloroplasts. Therefore, hexose phosphates would not move out of chloroplasts without the input of energy. The authors conclude that most carbon leaves chloroplasts at night as Glc, maltose, or higher maltodextrins under normal conditions.« less

  1. 7 CFR 1493.470 - Evidence of export.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... OF AGRICULTURE LOANS, PURCHASES, AND OTHER OPERATIONS CCC EXPORT CREDIT GUARANTEE PROGRAMS CCC... exporter is required to provide CCC an evidence of export report for each shipment made under the payment... participation in any of the following CCC or USDA export program: Export Enhancement Program, Dairy Export...

  2. 7 CFR 1493.80 - Evidence of export.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... OF AGRICULTURE LOANS, PURCHASES, AND OTHER OPERATIONS CCC EXPORT CREDIT GUARANTEE PROGRAMS CCC Export Credit Guarantee Program (GSM-102) and CCC Intermediate Export Credit Guarantee Program (GSM-103) Operations § 1493.80 Evidence of export. (a) Report of export. The exporter is required to provide CCC an...

  3. Rainfall as primary driver of discharge and solute export from rock glaciers: The Col d'Olen Rock Glacier in the NW Italian Alps.

    PubMed

    Colombo, Nicola; Gruber, Stephan; Martin, Maria; Malandrino, Mery; Magnani, Andrea; Godone, Danilo; Freppaz, Michele; Fratianni, Simona; Salerno, Franco

    2018-10-15

    Three hypotheses exist to explain how meteorological variables drive the amount and concentration of solute-enriched water from rock glaciers: (1) Warm periods cause increased subsurface ice melt, which releases solutes; (2) rain periods and the melt of long-lasting snow enhance dilution of rock-glacier outflows; and (3) percolation of rain through rock glaciers facilitates the export of solutes, causing an opposite effect as that described in hypothesis (2). This lack of detailed understanding likely exists because suitable studies of meteorological variables, hydrologic processes and chemical characteristics of water bodies downstream from rock glaciers are unavailable. In this study, a rock-glacier pond in the North-Western Italian Alps was studied on a weekly basis for the ice-free seasons 2014 and 2015 by observing the meteorological variables (air temperature, snowmelt, rainfall) assumed to drive the export of solute-enriched waters from the rock glacier and the hydrochemical response of the pond (water temperature as a proxy of rock-glacier discharge, stable water isotopes, major ions and selected trace elements). An intra-seasonal pattern of increasing solute export associated with higher rock-glacier discharge was found. Specifically, rainfall, after the winter snowpack depletion and prolonged periods of atmospheric temperature above 0 °C, was found to be the primary driver of solute export from the rock glacier during the ice-free season. This occurs likely through the flushing of isotopically- and geochemically-enriched icemelt, causing concomitant increases in the rock-glacier discharge and the solute export (SO 4 2- , Mg 2+ , Ca 2+ , Ni, Mn, Co). Moreover, flushing of microbially-active sediments can cause increases in NO 3 - export. Copyright © 2018 Elsevier B.V. All rights reserved.

  4. Forecasting on the total volumes of Malaysia's imports and exports by multiple linear regression

    NASA Astrophysics Data System (ADS)

    Beh, W. L.; Yong, M. K. Au

    2017-04-01

    This study is to give an insight on the doubt of the important of macroeconomic variables that affecting the total volumes of Malaysia's imports and exports by using multiple linear regression (MLR) analysis. The time frame for this study will be determined by using quarterly data of the total volumes of Malaysia's imports and exports covering the period between 2000-2015. The macroeconomic variables will be limited to eleven variables which are the exchange rate of US Dollar with Malaysia Ringgit (USD-MYR), exchange rate of China Yuan with Malaysia Ringgit (RMB-MYR), exchange rate of European Euro with Malaysia Ringgit (EUR-MYR), exchange rate of Singapore Dollar with Malaysia Ringgit (SGD-MYR), crude oil prices, gold prices, producer price index (PPI), interest rate, consumer price index (CPI), industrial production index (IPI) and gross domestic product (GDP). This study has applied the Johansen Co-integration test to investigate the relationship among the total volumes to Malaysia's imports and exports. The result shows that crude oil prices, RMB-MYR, EUR-MYR and IPI play important roles in the total volumes of Malaysia's imports. Meanwhile crude oil price, USD-MYR and GDP play important roles in the total volumes of Malaysia's exports.

  5. Design and implementation of relational databases relevant to the diverse needs of a tuberculosis case contact study in the Gambia.

    PubMed

    Jeffries, D J; Donkor, S; Brookes, R H; Fox, A; Hill, P C

    2004-09-01

    The data requirements of a large multidisciplinary tuberculosis case contact study are complex. We describe an ACCESS-based relational database system that meets our rigorous requirements for data entry and validation, while being user-friendly, flexible, exportable, and easy to install on a network or stand alone system. This includes the development of a double data entry package for epidemiology and laboratory data, semi-automated entry of ELISPOT data directly from the plate reader, and a suite of new programmes for the manipulation and integration of flow cytometry data. The double entered epidemiology and immunology databases are combined into a separate database, providing a near-real-time analysis of immuno-epidemiological data, allowing important trends to be identified early and major decisions about the study to be made and acted on. This dynamic data management model is portable and can easily be applied to other studies.

  6. The Role of Stream Water Carbon Dynamics and Export in the Carbon Balance of a Tropical Seasonal Rainforest, Southwest China

    PubMed Central

    Zhou, Wen-Jun; Zhang, Yi-Ping; Schaefer, Douglas A.; Sha, Li-Qing; Deng, Yun; Deng, Xiao-Bao; Dai, Kai-Jie

    2013-01-01

    A two-year study (2009 ∼ 2010) was carried out to investigate the dynamics of different carbon (C) forms, and the role of stream export in the C balance of a 23.4-ha headwater catchment in a tropical seasonal rainforest at Xishuangbanna (XSBN), southwest China. The seasonal volumetric weighted mean (VWM) concentrations of total inorganic C (TIC) and dissolved inorganic C (DIC) were higher, and particulate inorganic C (PIC) and organic C (POC) were lower, in the dry season than the rainy season, while the VWM concentrations of total organic C (TOC) and dissolved organic C (DOC) were similar between seasons. With increased monthly stream discharge and stream water temperature (SWT), only TIC and DIC concentrations decreased significantly. The most important C form in stream export was DIC, accounting for 51.8% of the total C (TC) export; DOC, POC, and PIC accounted for 21.8%, 14.9%, and 11.5% of the TC export, respectively. Dynamics of C flux were closely related to stream discharge, with the greatest export during the rainy season. C export in the headwater stream was 47.1 kg C ha−1 yr−1, about 2.85% of the annual net ecosystem exchange. This finding indicates that stream export represented a minor contribution to the C balance in this tropical seasonal rainforest. PMID:23437195

  7. The role of stream water carbon dynamics and export in the carbon balance of a tropical seasonal rainforest, southwest China.

    PubMed

    Zhou, Wen-Jun; Zhang, Yi-Ping; Schaefer, Douglas A; Sha, Li-Qing; Deng, Yun; Deng, Xiao-Bao; Dai, Kai-Jie

    2013-01-01

    A two-year study (2009 ~ 2010) was carried out to investigate the dynamics of different carbon (C) forms, and the role of stream export in the C balance of a 23.4-ha headwater catchment in a tropical seasonal rainforest at Xishuangbanna (XSBN), southwest China. The seasonal volumetric weighted mean (VWM) concentrations of total inorganic C (TIC) and dissolved inorganic C (DIC) were higher, and particulate inorganic C (PIC) and organic C (POC) were lower, in the dry season than the rainy season, while the VWM concentrations of total organic C (TOC) and dissolved organic C (DOC) were similar between seasons. With increased monthly stream discharge and stream water temperature (SWT), only TIC and DIC concentrations decreased significantly. The most important C form in stream export was DIC, accounting for 51.8% of the total C (TC) export; DOC, POC, and PIC accounted for 21.8%, 14.9%, and 11.5% of the TC export, respectively. Dynamics of C flux were closely related to stream discharge, with the greatest export during the rainy season. C export in the headwater stream was 47.1 kg C ha(-1) yr(-1), about 2.85% of the annual net ecosystem exchange. This finding indicates that stream export represented a minor contribution to the C balance in this tropical seasonal rainforest.

  8. Magnified Sediment Export of Small Mountainous Rivers in Taiwan: Chain Reactions from Increased Rainfall Intensity under Global Warming.

    PubMed

    Lee, Tsung-Yu; Huang, Jr-Chuan; Lee, Jun-Yi; Jien, Shih-Hao; Zehetner, Franz; Kao, Shuh-Ji

    2015-01-01

    Fluvial sediment export from small mountainous rivers in Oceania has global biogeochemical significance affecting the turnover rate and export of terrestrial carbon, which might be speeding up at the recognized conditions of increased rainfall intensity. In this study, the historical runoff and sediment export from 16 major rivers in Taiwan are investigated and separated into an early stage (1970-1989) and a recent stage (1990-2010) to illustrate the changes of both runoff and sediment export. The mean daily sediment export from Taiwan Island in the recent stage significantly increased by >80% with subtle increase in daily runoff, indicating more sediment being delivered to the ocean per unit of runoff in the recent stage. The medians of the runoff depth and sediment yield extremes (99.0-99.9 percentiles) among the 16 rivers increased by 6.5%-37% and 62%-94%, respectively, reflecting the disproportionately magnified response of sediment export to the increased runoff. Taiwan is facing increasing event rainfall intensity which has resulted in chain reactions on magnified runoff and sediment export responses. As the globe is warming, rainfall extremes, which are proved to be temperature-dependent, very likely intensify runoff and trigger more sediment associated hazards. Such impacts might occur globally because significant increases of high-intensity precipitation have been observed not only in Taiwan but over most land areas of the globe.

  9. China's "Exported Carbon" Peak: Patterns, Drivers, and Implications

    NASA Astrophysics Data System (ADS)

    Mi, Zhifu; Meng, Jing; Green, Fergus; Coffman, D'Maris; Guan, Dabo

    2018-05-01

    Over the past decade, China has entered a "new normal" phase in economic development, with its role in global trade flows changing significantly. This study estimates the driving forces of Chinese export-embodied carbon emissions in the new normal phase, based on environmentally extended multiregional input-output modeling and structural decomposition analysis. We find that Chinese export-embodied CO2 emissions peaked in 2008 at a level of 1,657 million tones. The subsequent decline in CO2 emissions was mainly due to the changing structure of Chinese production. The peak in Chinese export-embodied emissions is encouraging from the perspective of global climate change mitigation, as it implies downward pressure on global CO2 emissions. However, more attention should focus on ensuring that countries that may partly replace China as major production bases increase their exports using low-carbon inputs.

  10. Export Time of Earthquake-Derived Landslides in Active Mountain Ranges

    NASA Astrophysics Data System (ADS)

    Croissant, T.; Lague, D.; Steer, P.; Davy, P.

    2016-12-01

    In active mountain ranges, large earthquakes (Mw > 5-6) trigger numerous landslides that impact river dynamics. These landslides bring local and sudden sediment deposits which are eroded and transported along the river network, causing downstream changes in river geometry, transport capacity and erosion efficiency. The progressive removal of landslide materials has implications for downstream hazards management and for landscape dynamics at the timescale of the seismic cycle. Although the export time of suspended sediments from landslides triggered by large-magnitude earthquakes has been extensively studied, the processes and time scales associated to bedload transport remains poorly studied. Here, we study the sediment export of large landslides with the 2D morphodynamic model, Eros. This model combines: (i) an hydrodynamic model, (ii) a sediment transport and deposition model and (iii) a lateral erosion model. Eros is particularly well suited for this issue as it accounts for the complex retro-actions between sediment transport and fluvial geometry for rivers submitted to external forcings such as abrupt sediment supply increase. Using a simplified synthetic topography we systematically study the influence of pulse volume (Vs) and channel transport capacity (QT) on the export time of landslides. The range of simulated river behavior includes landslide vertical incision, its subsequent removal by lateral erosion and the river morphology modifications induced by downstream sediment propagation. The morphodynamic adaptation of the river increases its transport capacity along the channel and tends to accelerate the landslide evacuation. Our results highlight two regimes: (i) the export time is linearly related to Vs/QT when the sediment pulse introduced in the river does not affect significantly the river hydrodynamic (low Vs/QT) and (ii) the export time is a non-linear function of Vs/QT when the pulse undergoes significant morphodynamic modifications during its evacuation (high Vs/QT). By combining our newly derived export time functions with the frequency-magnitude of earthquake intensity and the induced sediment production, we investigate the sediment export of several plausible earthquake scenarii in different mountain ranges (New Zealand, Taiwan, Nepal).

  11. Permafrost conditions in peatlands regulate magnitude, timing, and chemical composition of catchment dissolved organic carbon export.

    PubMed

    Olefeldt, David; Roulet, Nigel T

    2014-10-01

    Permafrost thaw in peatlands has the potential to alter catchment export of dissolved organic carbon (DOC) and thus influence downstream aquatic C cycling. Subarctic peatlands are often mosaics of different peatland types, where permafrost conditions regulate the hydrological setting of each type. We show that hydrological setting is key to observed differences in magnitude, timing, and chemical composition of DOC export between permafrost and nonpermafrost peatland types, and that these differences influence the export of DOC of larger catchments even when peatlands are minor catchment components. In many aspects, DOC export from a studied peatland permafrost plateau was similar to that of a forested upland catchment. Similarities included low annual export (2-3 g C m(-2) ) dominated by the snow melt period (~70%), and how substantial DOC export following storms required wet antecedent conditions. Conversely, nonpermafrost fens had higher DOC export (7 g C m(-2) ), resulting from sustained hydrological connectivity during summer. Chemical composition of catchment DOC export arose from the mixing of highly aromatic DOC from organic soils from permafrost plateau soil water and upland forest surface horizons with nonaromatic DOC from mineral soil groundwater, but was further modulated by fens. Increasing aromaticity from fen inflow to outlet was substantial and depended on both water residence time and water temperature. The role of fens as catchment biogeochemical hotspots was further emphasized by their capacity for sulfate retention. As a result of fen characteristics, a 4% fen cover in a mixed catchment was responsible for 34% higher DOC export, 50% higher DOC concentrations and ~10% higher DOC aromaticity at the catchment outlet during summer compared to a nonpeatland upland catchment. Expansion of fens due to thaw thus has potential to influence landscape C cycling by increasing fen capacity to act as biogeochemical hotspots, amplifying aquatic C cycling, and increasing catchment DOC export. © 2014 John Wiley & Sons Ltd.

  12. 27 CFR 53.179 - Supporting evidence required in case of manufacturers tax involving exportations, uses, sales, or...

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... chain of sales from the person who paid the tax to the ultimate purchaser, the evidence required to be... vendor retains such proof for 3 years from the date of the statement and will, upon request, supply such...

  13. 27 CFR 53.179 - Supporting evidence required in case of manufacturers tax involving exportations, uses, sales, or...

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... chain of sales from the person who paid the tax to the ultimate purchaser, the evidence required to be... vendor retains such proof for 3 years from the date of the statement and will, upon request, supply such...

  14. 76 FR 70805 - Bureau of Political-Military Affairs; Statutory Debarment Under the Arms Export Control Act and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-15

    ...:10CR01201-001; May 1988. (16) Fidel Jesus Hernandez; November 23, 2010; U.S. District Court, District of... of Florida; Case No. 0:10CR60177-COHN-2; December 1956. (26) Jose Jesus Miramontes-Duarte; April 23...

  15. 27 CFR 53.179 - Supporting evidence required in case of manufacturers tax involving exportations, uses, sales, or...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... chain of sales from the person who paid the tax to the ultimate purchaser, the evidence required to be... vendor retains such proof for 3 years from the date of the statement and will, upon request, supply such...

  16. 27 CFR 53.179 - Supporting evidence required in case of manufacturers tax involving exportations, uses, sales, or...

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... chain of sales from the person who paid the tax to the ultimate purchaser, the evidence required to be... vendor retains such proof for 3 years from the date of the statement and will, upon request, supply such...

  17. 10 CFR 74.81 - Inspections.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Inspections. 74.81 Section 74.81 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) MATERIAL CONTROL AND ACCOUNTING OF SPECIAL NUCLEAR MATERIAL Enforcement § 74.81..., import, export, or transfer of special nuclear material. (c)(1) In the case of fuel cycle facilities...

  18. Recognizing Child Maltreatment in Bangladesh. Brief Communication.

    ERIC Educational Resources Information Center

    Khan, Naila Z.; Lynch, Margaret A.

    1997-01-01

    Highlights the range of cases of child abuse and neglect already being identified by professionals in Bangladesh. Also discusses the larger paradoxes revolving around child protection related to sociocultural practices and economic factors, including early marriage of girls, domestic child workers, and child labor in export factories. (CR)

  19. E-government factors to reduce administrative and finance corruption in Arab countries: Case study Iraqi oil sector

    NASA Astrophysics Data System (ADS)

    Mohammed, M. A.; Eman, Y.; Hussein, A. H.; Hasson, A. R.

    2015-12-01

    Arab countries face the corruption issues in its several public organizations. The corruption in these countries is considered as the main challenge. The oil sector is one of the public sectors that have huge level of corruption. However, the Iraqi economy had become dependable on oil sector daring the last three decades, and on the contrary, of what other oil countries did. The capital is considered as one of the essential factor for economic development. The revenues of oil exports will stay the essential source for economic development in Iraq in the future in order to reduce being dependable on oil. Since the beginning of the 3rd thousands, the world witnessed great rise in the demand on oil, but the Iraqi exports of crude oil come to be less than its similarities in the seventeenths of last century. So our oil sector is still in need of deep study. This study focuses on technological technique that can make huge decrease for corruption in oil sector in Iraq. However, e-government is considered as the best techniques that can decrease the corruption. Thus, this study bases on challenges that effect on build successful e-government project in Iraqi oil industry.

  20. An improved export coefficient model to estimate non-point source phosphorus pollution risks under complex precipitation and terrain conditions.

    PubMed

    Cheng, Xian; Chen, Liding; Sun, Ranhao; Jing, Yongcai

    2018-05-15

    To control non-point source (NPS) pollution, it is important to estimate NPS pollution exports and identify sources of pollution. Precipitation and terrain have large impacts on the export and transport of NPS pollutants. We established an improved export coefficient model (IECM) to estimate the amount of agricultural and rural NPS total phosphorus (TP) exported from the Luanhe River Basin (LRB) in northern China. The TP concentrations of rivers from 35 selected catchments in the LRB were used to test the model's explanation capacity and accuracy. The simulation results showed that, in 2013, the average TP export was 57.20 t at the catchment scale. The mean TP export intensity in the LRB was 289.40 kg/km 2 , which was much higher than those of other basins in China. In the LRB topographic regions, the TP export intensity was the highest in the south Yanshan Mountains and was followed by the plain area, the north Yanshan Mountains, and the Bashang Plateau. Among the three pollution categories, the contribution ratios to TP export were, from high to low, the rural population (59.44%), livestock husbandry (22.24%), and land-use types (18.32%). Among all ten pollution sources, the contribution ratios from the rural population (59.44%), pigs (14.40%), and arable land (10.52%) ranked as the top three sources. This study provides information that decision makers and planners can use to develop sustainable measures for the prevention and control of NPS pollution in semi-arid regions.

  1. Latitudinal distributions of particulate carbon export across the North Western Atlantic Ocean

    NASA Astrophysics Data System (ADS)

    Puigcorbé, Viena; Roca-Martí, Montserrat; Masqué, Pere; Benitez-Nelson, Claudia; Rutgers van der Loeff, Michiel; Bracher, Astrid; Moreau, Sebastien

    2017-11-01

    234Th-derived carbon export fluxes were measured in the Atlantic Ocean under the GEOTRACES framework to evaluate basin-scale export variability. Here, we present the results from the northern half of the GA02 transect, spanning from the equator to 64°N. As a result of limited site-specific C/234Th ratio measurements, we further combined our data with previous work to develop a basin wide C/234Th ratio depth curve. While the magnitude of organic carbon fluxes varied depending on the C/234Th ratio used, latitudinal trends were similar, with sizeable and variable organic carbon export fluxes occurring at high latitudes and low to negligible fluxes occurring in oligotrophic waters. Our results agree with previous studies, except at the boundaries between domains, where fluxes were relatively enhanced. Three different models were used to obtain satellite-derived net primary production (NPP). In general, NPP estimates had similar trends along the transect, but there were significant differences in the absolute magnitude depending on the model used. Nevertheless, organic carbon export efficiencies were generally < 25%, with the exception of a few stations located in the transition area between the riverine and the oligotrophic domains and between the oligotrophic and the temperate domains. Satellite-derived organic carbon export models from Dunne et al. (2005) (D05), Laws et al. (2011) (L11) and Henson et al. (2011) (H11) were also compared to our 234Th-derived carbon exports fluxes. D05 and L11 provided estimates closest to values obtained with the 234Th approach (within a 3-fold difference), but with no clear trends. The H11 model, on the other hand, consistently provided lower export estimates. The large increase in export data in the Atlantic Ocean derived from the GEOTRACES Program, combined with satellite observations and modeling efforts continue to improve the estimates of carbon export in this ocean basin and therefore reduce uncertainty in the global carbon budget. However, our results also suggest that tuning export models and including biological parameters at a regional scale is necessary for improving satellite-modeling efforts and providing export estimates that are more representative of in situ observations.

  2. Resource nationalism in Indonesia—Effects of the 2014 mineral export ban

    USGS Publications Warehouse

    Lederer, Graham W.

    2016-09-27

    Resource nationalism encompasses a broad range of political and economic actions taken by Governments to regulate the extraction of natural resources within their borders. Policies such as increased tariffs or export restrictions can have far-reaching economic effects on international trade. As the Governments of several developing countries consider enacting nationalistic policies, an examination of the 2014 mineral export ban in Indonesia provides an instructive example of the possible impacts of resource nationalism. Significant changes in the production and trade of unprocessed (that is, ores and concentrates) and processed (that is, refined metal) aluminum, copper, and nickel before and after the export ban form the basis of this study.The U.S. Geological Survey (USGS) National Minerals Information Center (NMIC) tracks production and trade of mineral commodities between producer and consumer countries. Materials flow studies clarify the effects of an export ban on different mineral commodities by assessing changes in production, processing capacity, and trade. Using extensive data collection and monitoring procedures, the USGS NMIC investigated the effects of resource nationalism on the flow of mineral commodities from Indonesia to the global economy.

  3. 22 CFR 123.22 - Filing, retention, and return of export licenses and filing of export information.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 22 Foreign Relations 1 2014-04-01 2014-04-01 false Filing, retention, and return of export licenses and filing of export information. 123.22 Section 123.22 Foreign Relations DEPARTMENT OF STATE....22 Filing, retention, and return of export licenses and filing of export information. (a) Any export...

  4. The Emerging Threat of Illicit Drug Funding of Terrorist Operations

    DTIC Science & Technology

    2003-04-01

    discrepancies associated with the study of drug exports and its specific weight in the Gross National Product (GNP). “Some consider that Colombia is not...fewer hands, contaminates exports , and distorts the relative prices of the goods desired by traffickers as well as the assignation of resources in the...stabilizing effect on the Nation’s financial institutions and currency. As such it (illicit drug exports ) are seen as being inextricably linked to the

  5. Informatics in radiology (infoRAD): Vendor-neutral case input into a server-based digital teaching file system.

    PubMed

    Kamauu, Aaron W C; DuVall, Scott L; Robison, Reid J; Liimatta, Andrew P; Wiggins, Richard H; Avrin, David E

    2006-01-01

    Although digital teaching files are important to radiology education, there are no current satisfactory solutions for export of Digital Imaging and Communications in Medicine (DICOM) images from picture archiving and communication systems (PACS) in desktop publishing format. A vendor-neutral digital teaching file, the Radiology Interesting Case Server (RadICS), offers an efficient tool for harvesting interesting cases from PACS without requiring modifications of the PACS configurations. Radiologists push imaging studies from PACS to RadICS via the standard DICOM Send process, and the RadICS server automatically converts the DICOM images into the Joint Photographic Experts Group format, a common desktop publishing format. They can then select key images and create an interesting case series at the PACS workstation. RadICS was tested successfully against multiple unmodified commercial PACS. Using RadICS, radiologists are able to harvest and author interesting cases at the point of clinical interpretation with minimal disruption in clinical work flow. RSNA, 2006

  6. U.S. hardwood product exports, hardwood exports to Korea, hardwood resource situation, and the future of U.S. exports to Korea

    Treesearch

    Philip A. Araman

    1991-01-01

    The exerpts from this seminar are intended to give an overview of U.S. hardwood exports, hardwood exports to Korea, the hardwood resource situation, and the future of U.S. hardwood exports to Korea. It includes 1) some basic information about total U.S. hardwood exports and products, 2) information on hardwood exports to Korea from the U.S., 3) U.S. hardwood resources...

  7. A Framework for the Design of Service Systems

    NASA Astrophysics Data System (ADS)

    Tan, Yao-Hua; Hofman, Wout; Gordijn, Jaap; Hulstijn, Joris

    We propose a framework for the design and implementation of service systems, especially to design controls for long-term sustainable value co-creation. The framework is based on the software support tool e3-control. To illustrate the framework we use a large-scale case study, the Beer Living Lab, for simplification of customs procedures in international trade. The BeerLL shows how value co-creation can be achieved by reduction of administrative burden in international beer export due to electronic customs. Participants in the BeerLL are Heineken, IBM and Dutch Tax & Customs.

  8. [Links and effects of globalization on social and economic organization and malaria prevalence in the Coastal Region of Livingston, Guatemala].

    PubMed

    Nelson, Caro Méndez

    2007-01-01

    As a result of Guatemala's growing involvement in international markets and policies favoring industrial and export-oriented efforts, the population has experienced substantial changes in its economic and social organization, with consequences for the health and well-being of marginal groups. The article discusses various links between global processes, national policies and priorities, social and economic strategies, and malaria prevalence, with the Coastal Region of Livingston, Guatemala as the case study carried out between 2001 and 2003.

  9. Exporting the Buyers Health Care Action Group Purchasing Model: Lessons from Other Communities

    PubMed Central

    Christianson, Jon B; Feldman, Roger

    2005-01-01

    When first implemented in Minneapolis and St. Paul, Minnesota, the Buyers Health Care Action Group's (BHCAG) purchasing approach received considerable attention as an employer-managed, consumer-driven health care model embodying many of the principles of managed competition. First BHCAG and, later, a for-profit management company attempted to export this model to other communities. Their efforts were met with resistance from local hospitals and, in many cases, apathy by employers who were expected to be supportive. This experience underscores several difficulties that appear to be inherent in implementing purchasing models based on competing care systems. It also, once again, suggests caution in drawing lessons from community-level experiments in purchasing health care. PMID:15787957

  10. Management Training and Development within Its Environment: The Case of Libyan Industrial Companies.

    ERIC Educational Resources Information Center

    Agnaia, Almehdi A.

    1997-01-01

    A survey of 45 Libyan industrial companies found that many were owned/managed by government agencies. Management training and development were constrained by political, social, and economic factors, such as policies and laws, customs and beliefs about work, and import/export restrictions. (SK)

  11. 22 CFR 126.1 - Prohibited exports and sales to certain countries.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ...-case basis, for supplies of arms and related materials or technical training and assistance intended... Haiti, supplies of arms and related materials for technical training and assistance intended solely for..., defense services or technical data subject to this subchapter may be made to any country referred to in...

  12. A Case for Preserving the Diversity of Madness

    ERIC Educational Resources Information Center

    Sarrett, Jennifer C.; Kushner, Howard I.

    2011-01-01

    Watters questions the universality of mental illness and warns of the harms that accompany the exportation of Western typologies to non-Western cultures. He is particularly concerned that these effects will be exacerbated by the upcoming revisions of the "Diagnostic and Statistical Manual of Mental Disorders" ("DSM-V").…

  13. 77 FR 74846 - Application for Final Commitment for a Long-Term Loan or Financial Guarantee in Excess of $100...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-18

    ... description of the purpose of the transaction: To support the export of locomotive kits to South Africa Brief... South Africa but also in some cases in nearby countries in Southern Africa. To the extent that Ex-Im...

  14. 27 CFR 53.142 - Denial, revocation or suspension of registration.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY (CONTINUED) FIREARMS MANUFACTURERS EXCISE TAXES... tax free under section 4221 of the Code in any case in which he finds that: (1) The registrant is not a bona fide manufacturer, or a purchaser reselling direct to manufacturers or exporters; (2) The...

  15. 22 CFR 127.5 - Authority of the Defense Security Service.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... ensure compliance with the Department of Defense National Industrial Security Program Operating Manual... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Authority of the Defense Security Service. 127... VIOLATIONS AND PENALTIES § 127.5 Authority of the Defense Security Service. In the case of exports involving...

  16. 21 CFR 1230.47 - Rejected containers.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Rejected containers. 1230.47 Section 1230.47 Food... FEDERAL CAUSTIC POISON ACT Imports § 1230.47 Rejected containers. (a) In all cases where the containers... notification to the importer that the containers must be exported under customs supervision within 3 months...

  17. 15 CFR 764.3 - Sanctions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... to the Secretary of Defense, except in the case of an individual, shall be fined not more than five... licenses (See section 11B of the EAA, Missile Proliferation Violations, and the Iran-Iraq Arms Non... Department of State may deny licenses or approvals for the export or reexport of defense articles and defense...

  18. Environmental Myopia: The Case for Bifocals

    ERIC Educational Resources Information Center

    North, Chris; Hutson, Garrett

    2011-01-01

    Domestic and international tourists have major impacts on Aotearoa/New Zealand, both positive and negative. In 2010, tourism was the biggest export earner and continues to grow. Environmental consequences of tourism are also growing. Ways of addressing the environmental impacts caused by a mobile society continue to be debated from a variety of…

  19. 19 CFR 141.85 - Pro forma invoice.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... purchased by me. The prices, or in the case of consigned goods the values, given below are true and correct... paid or agreed to be paid (_) as per order dated ______. (b) Advices from exporter by letter (—) by... States (if U.S. Value) (_) ______. (f) Advices of the Port Director (_) ______. (g) Other (_) ______. A...

  20. 9 CFR 96.1 - Definitions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 9 Animals and Animal Products 1 2013-01-01 2013-01-01 false Definitions. 96.1 Section 96.1 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE EXPORTATION AND IMPORTATION OF ANIMALS (INCLUDING POULTRY) AND ANIMAL PRODUCTS RESTRICTION OF IMPORTATIONS OF FOREIGN ANIMAL CASINGS OFFERED FOR ENTRY INTO TH...

  1. 9 CFR 96.1 - Definitions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 9 Animals and Animal Products 1 2014-01-01 2014-01-01 false Definitions. 96.1 Section 96.1 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE EXPORTATION AND IMPORTATION OF ANIMALS (INCLUDING POULTRY) AND ANIMAL PRODUCTS RESTRICTION OF IMPORTATIONS OF FOREIGN ANIMAL CASINGS OFFERED FOR ENTRY INTO TH...

  2. Impacts of Changed Extratropical Storm Tracks on Arctic Sea Ice Export through Fram Strait

    NASA Astrophysics Data System (ADS)

    Wei, J.; Zhang, X.; Wang, Z.

    2017-12-01

    Studies have indicated a poleward shift of extratropical storm tracks and intensification of Arctic storm activities, in particular on the North Atlantic side of the Arctic Ocean. To improve understanding of dynamic effect on changes in Arctic sea ice mass balance, we examined the impacts of the changed storm tracks and activities on Arctic sea ice export through Fram Strait through ocean-sea ice model simulations. The model employed is the high-resolution Massachusetts Institute of Technology general circulation model (MITgcm), which was forced by the Japanese 25-year Reanalysis (JRA-25) dataset. The results show that storm-induced strong northerly wind stress can cause simultaneous response of daily sea ice export and, in turn, exert cumulative effects on interannual variability and long-term changes of sea ice export. Further analysis indicates that storm impact on sea ice export is spatially dependent. The storms occurring southeast of Fram Strait exhibit the largest impacts. The weakened intensity of winter storms in this region after 1994/95 could be responsible for the decrease of total winter sea ice export during the same time period.

  3. Regulation of mRNA Trafficking by Nuclear Pore Complexes

    PubMed Central

    Bonnet, Amandine; Palancade, Benoit

    2014-01-01

    Over the last two decades, multiple studies have explored the mechanisms governing mRNA export out of the nucleus, a crucial step in eukaryotic gene expression. During transcription and processing, mRNAs are assembled into messenger ribonucleoparticles (mRNPs). mRNPs are then exported through nuclear pore complexes (NPCs), which are large multiprotein assemblies made of several copies of a limited number of nucleoporins. A considerable effort has been put into the dissection of mRNA export through NPCs at both cellular and molecular levels, revealing the conserved contributions of a subset of nucleoporins in this process, from yeast to vertebrates. Several reports have also demonstrated the ability of NPCs to sort out properly-processed mRNPs for entry into the nuclear export pathway. Importantly, changes in mRNA export have been associated with post-translational modifications of nucleoporins or changes in NPC composition, depending on cell cycle progression, development or exposure to stress. How NPC modifications also impact on cellular mRNA export in disease situations, notably upon viral infection, is discussed. PMID:25184662

  4. Enhanced POC export in the oligotrophic northwest Pacific Ocean after extreme weather events

    NASA Astrophysics Data System (ADS)

    Chen, Kuo-Shu; Hung, Chin-Chang; Gong, Gwo-Ching; Chou, Wen-Chen; Chung, Chih-Ching; Shih, Yung-Yen; Wang, Chau-Chang

    2013-11-01

    study effects of extreme weather events (EWEs, e.g., dust storm and typhoon) on the export of particulate organic carbon (POC) measured by a floating sediment trap in the oligotrophic ocean, eight sea-going expeditions were conducted in the oligotrophic northwest Pacific (NWP) in 2007 and 2008, covering all four seasons and the passage of several EWEs. Results of year-round field observations demonstrate that the POC export fluxes in the oligotrophic NWP did not exhibit apparent seasonal variations yielding an average flux of 36.9 ± 5.8 mg-C m-2 d-1 without EWE effects. With EWE effects, however, the POC export flux (51.7 ± 13.2 mg-C m-2 d-1) showed an approximately 40% increase compared to the average flux measured without EWE effects. These results suggest that EWEs can trigger elevated POC export from the euphotic zone in the oligotrophic ocean.

  5. Globalization of the pharmaceutical industry and the growing dependency of developing countries: the case of Turkey.

    PubMed

    Semin, Semih; Güldal, Dilek

    2008-01-01

    In developing countries, the effect of globalization on the pharmaceutical sector has resulted in a decrease in exportation and domestic production, accompanied by an increase in importation of pharmaceuticals and a rise in prices and expenditures. As an example of a developing country, Turkey has been facing the long-standing and increasing pressure of global regulations placed on its pharmaceutical sector. This has led to an increasing dependency on multinational companies and a gradual deterioration of an already weakened domestic pharmaceutical sector. This case study of Turkey offers points to consider in the world of increasing globalization, as it offers lessons on ways of examining the effects of globalization on the pharmaceutical industry of developing countries.

  6. 15 CFR 752.15 - Export clearance.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 15 Commerce and Foreign Trade 2 2010-01-01 2010-01-01 false Export clearance. 752.15 Section 752... OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE EXPORT ADMINISTRATION REGULATIONS SPECIAL COMPREHENSIVE LICENSE § 752.15 Export clearance. (a) Shipper's Export Declaration (SED) or Automated Export...

  7. The Economic Value of Remote Sensing of Earth Resources from Space: An ERTS Overview and the Value of Continuity of Service. Volume 1: Summary

    NASA Technical Reports Server (NTRS)

    Hazelrigg, G. A., Jr.; Heiss, K. P.

    1974-01-01

    An overview of the ERTS program is given to determine the magnitude of the benefits that can be reasonably expected to flow from an Earth Resources Survey (ERS) Program, and to assess the benefits foregone in the event of a one or two-year gap in ERS services. An independent evaluation of the benefits attributable to ERS-derived information in key application areas is presented. These include two case studies in agriculture-distribution, production and import/export, and one study in water management. The cost-effectiveness of satellites in an ERS system is studied by means of a land cover case study. The annual benefits achieveable from an ERS system are measured by the in-depth case studies to be in the range of $430 to $746 million. Benefits foregone in the event of a one-year gap in ERS service are estimated to be $147 to $220 million and $274 to $420 million for a two-year gap in ERS service.

  8. Portfolio Purchasing Decision for Mobile Power Equipment of B2C E-Commerce Export Retailer Based on CVaR

    NASA Astrophysics Data System (ADS)

    Yanchun, Wan; Qiucen, Chen

    2017-11-01

    Purchasing is an important part of export e-commerce of B2C, which plays an important role on risk and cost control in supply management. From the perspective of risk control, the paper construct a CVaR model for portfolio purchase. We select a heavy sales mobile power equipment from a typical B2C e-commerce export retailer as study sample. This study optimizes the purchasing strategy of this type of mobile power equipment. The research has some reference for similar enterprises in purchasing portfolio decision.

  9. 78 FR 37518 - Order Denying Export Privileges

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-21

    ... DEPARTMENT OF COMMERCE Bureau of Industry and Security Order Denying Export Privileges In the... Texas, Lee Roy Perez (``Perez'') was convicted of violating Section 38 of the Arms Export Control Act... of knowingly and willfully exporting and causing to be exported and attempting to export and...

  10. 7 CFR 1493.130 - Recovery of losses.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... OF AGRICULTURE EXPORT PROGRAMS CCC EXPORT CREDIT GUARANTEE PROGRAMS CCC Export Credit Guarantee Program (GSM-102) and CCC Intermediate Export Credit Guarantee Program (GSM-103) Operations § 1493.130 Recovery of losses. (a) Notification. Upon payment of loss to the exporter or the exporter's assignee, CCC...

  11. 7 CFR 1493.130 - Recovery of losses.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... OF AGRICULTURE EXPORT PROGRAMS CCC EXPORT CREDIT GUARANTEE PROGRAMS CCC Export Credit Guarantee Program (GSM-102) and CCC Intermediate Export Credit Guarantee Program (GSM-103) Operations § 1493.130 Recovery of losses. (a) Notification. Upon payment of loss to the exporter or the exporter's assignee, CCC...

  12. 7 CFR 1493.130 - Recovery of losses.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... OF AGRICULTURE EXPORT PROGRAMS CCC EXPORT CREDIT GUARANTEE PROGRAMS CCC Export Credit Guarantee Program (GSM-102) and CCC Intermediate Export Credit Guarantee Program (GSM-103) Operations § 1493.130 Recovery of losses. (a) Notification. Upon payment of loss to the exporter or the exporter's assignee, CCC...

  13. Empirical Studies Development Of Creative Industry Its Contribution To Make-Up Of Product Orientation Exporting In Denpasar-Bali

    NASA Astrophysics Data System (ADS)

    Suryathi, W.; Gede, I. G. K.

    2018-01-01

    The puIDRose of this study are : 1) to study the model of development of creative industries which export-oriented in Denpasar 2) to examine the main problems and constraints faced by creative industries 3) to know the increasing of product export in Denpasar.The number of samples are 15 creatives industries such as sub-sector of handicraft, fashion and culinary. Sampling technique used cluster and puIDRosive sampling. Data collection by interview, observation, literature study and questioner. Data analysis using qualitative and quantitative description. The results of this study explain: The model development of creative industry in Denpasar City basically consist of three phases that is : development input, development process and development output. The problems and business constraints in creative industries about skill and salary of human resources, capital of financial, promotion of marketing, raw material of resources, technology and modern administration of production. From the product export showed that woods were hight one of crafting sub sector, textiles were hight one of fashion sub sector, tuna fish were hight one of culinary sub sector.

  14. Climate and society in 20th century Mexico

    NASA Technical Reports Server (NTRS)

    Liverman, Diana M.

    1991-01-01

    Mexican agriculture has been greatly transformed by the widespread introduction of 'Green Revolution' technologies (irrigation, chemical fertilizers, and improved seeds), through land reform, and by land use policies oriented to export crops and grain production. Drought prone Mexico provides an excellent case to study how technological and social changes alter the impact of drought on food and agricultural system. A goal is to document and understand how relationships between climate and agriculture in Mexico have changed in the last fifty years. The results for several locations will be interpreted in light of the prospects of regional climate change due to global warming. This analysis will be complimented by four case studies of vulnerability to drought which will use local records and interviews to try and show how environmental, technological, and social changes may have altered the impacts of climate on local agricultural systems.

  15. Magnified Sediment Export of Small Mountainous Rivers in Taiwan: Chain Reactions from Increased Rainfall Intensity under Global Warming

    PubMed Central

    Lee, Tsung-Yu; Huang, Jr-Chuan; Lee, Jun-Yi; Jien, Shih-Hao; Zehetner, Franz; Kao, Shuh-Ji

    2015-01-01

    Fluvial sediment export from small mountainous rivers in Oceania has global biogeochemical significance affecting the turnover rate and export of terrestrial carbon, which might be speeding up at the recognized conditions of increased rainfall intensity. In this study, the historical runoff and sediment export from 16 major rivers in Taiwan are investigated and separated into an early stage (1970–1989) and a recent stage (1990–2010) to illustrate the changes of both runoff and sediment export. The mean daily sediment export from Taiwan Island in the recent stage significantly increased by >80% with subtle increase in daily runoff, indicating more sediment being delivered to the ocean per unit of runoff in the recent stage. The medians of the runoff depth and sediment yield extremes (99.0–99.9 percentiles) among the 16 rivers increased by 6.5%-37% and 62%-94%, respectively, reflecting the disproportionately magnified response of sediment export to the increased runoff. Taiwan is facing increasing event rainfall intensity which has resulted in chain reactions on magnified runoff and sediment export responses. As the globe is warming, rainfall extremes, which are proved to be temperature-dependent, very likely intensify runoff and trigger more sediment associated hazards. Such impacts might occur globally because significant increases of high-intensity precipitation have been observed not only in Taiwan but over most land areas of the globe. PMID:26372356

  16. 76 FR 9550 - President's Export Council: Meeting of the President's Export Council

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-18

    ... DEPARTMENT OF COMMERCE International Trade Administration President's Export Council: Meeting of the President's Export Council AGENCY: International Trade Administration, U.S. Department of Commerce.... exports, jobs, and growth. DATES: March 11, 2011 at 9:30 a.m. (ET). ADDRESSES: The President's Export...

  17. 78 FR 37787 - Order Denying Export Privileges

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-24

    ... DEPARTMENT OF COMMERCE Bureau of Industry and Security Order Denying Export Privileges In the... District of Texas, Manuel Mario Pavon (``Pavon'') was convicted of violating Section 38 of the Arms Export... knowingly and willfully exporting and causing to be exported and attempting to export and attempting to...

  18. 75 FR 54540 - Effects of Foreign Policy-Based Export Controls

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-08

    .... 100719301-0303-02] Effects of Foreign Policy-Based Export Controls AGENCY: Bureau of Industry and Security... foreign policy-based export controls in the Export Administration Regulations to determine whether they... comments on how existing foreign policy-based export controls have affected exporters and the general...

  19. US Shipbuilding International Market Study, 1996-2005

    DTIC Science & Technology

    1995-06-02

    export potential is very good in all sectors, and coupled with the strong US ownership in this sector, this should provide good opportunities for US...usual in a small ship sector. Greatest opportunities will therefore arise for US shipyards from the NAFTA region. • Export opportunities improve with...are few, and export potential is good. Having said this, it should be kept in mind that order numbers are very low: this is a very small niche market

  20. (Initiation of strategic assessment of fossil options, Phase 2). Summary. Progress report, November 1981-February 1982. [USA; coal transhipment capacity in 1990 for 37 ports

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kocur, G.; Adler, T.J.

    1982-02-23

    The export coal transportation study has proceeded through the first two subtasks. Figure 1 shows a comparison between past and projected US coal export demand and US port coal transshipment capacities. Projected export demand was taken from the MIT World Coal Study, and projected port capacities were determined primarily by personal communications with port managers. Table 1 details projected 1990 capacities at each major port, with a maximum-minimum range indicating undertain projects. The obvious observation from these data is the massive discrepancy between projected capacities and projected export movements. It is very likely that many ports have publicized ambitious expansionmore » plans in order to discourage competing ports from expanding. In addition, the excess port capacity could be used for exports of, for example, iron ore and grain. Nonetheless, Fig. 1 does indicate some need to determine which subset of ports will lie on the most cost-effective routing from mine to ultimate destination and which thus deserve the largest investments. The survey of rail export (steam) coal rates began with an identification of representative mines (13) to port (19) movement (total of 54 allowable). Per carload rail rates were then obtained for approximately 25 of these movements. Regression analyses were performed relating these rates to shipping distance, and other factors. 1 figure, 1 table.« less

  1. Human TREX2 components PCID2 and centrin 2, but not ENY2, have distinct functions in protein export and co-localize to the centrosome.

    PubMed

    Cunningham, Corey N; Schmidt, Casey A; Schramm, Nathaniel J; Gaylord, Michelle R; Resendes, Karen K

    2014-01-15

    TREX-2 is a five protein complex, conserved from yeast to humans, involved in linking mRNA transcription and export. The centrin 2 subunit of TREX-2 is also a component of the centrosome and is additionally involved in a distinctly different process of nuclear protein export. While centrin 2 is a known multifunctional protein, the roles of other human TREX-2 complex proteins other than mRNA export are not known. In this study, we found that human TREX-2 member PCID2 but not ENY2 is involved in some of the same cellular processes as those of centrin 2 apart from the classical TREX-2 function. PCID2 is present at the centrosome in a subset of HeLa cells and this localization is centrin 2 dependent. Furthermore, the presence of PCID2 at the centrosome is prevalent throughout the cell cycle as determined by co-staining with cyclins E, A and B. PCID2 but not ENY2 is also involved in protein export. Surprisingly, siRNA knockdown of PCID2 delayed the rate of nuclear protein export, a mechanism distinct from the effects of centrin 2, which when knocked down inhibits export. Finally we showed that co-depletion of centrin 2 and PCID2 leads to blocking rather than delaying nuclear protein export, indicating the dominance of the centrin 2 phenotype. Together these results represent the first discovery of specific novel functions for PCID2 other than mRNA export and suggest that components of the TREX-2 complex serve alternative shared roles in the regulation of nuclear transport and cell cycle progression. © 2013 Published by Elsevier Inc.

  2. Quantifying export production in the Southern Ocean: Implications for the Baxs proxy

    NASA Astrophysics Data System (ADS)

    Hernandez-Sanchez, Maria T.; Mills, Rachel A.; Planquette, HéLèNe; Pancost, Richard D.; Hepburn, Laura; Salter, Ian; Fitzgeorge-Balfour, Tania

    2011-12-01

    The water column and sedimentary Baxs distribution around the Crozet Plateau is used to decipher the controls and timing of barite formation and to evaluate how export production signals are recorded in sediments underlying a region of natural Fe fertilization within the Fe limited Southern Ocean. Export production estimated from preserved, vertical sedimentary Baxs accumulation rates are compared with published export fluxes assessed from an integrated study of the biological carbon pump to determine the validity of Baxs as a quantitative proxy under different Fe supply conditions typical of the Southern Ocean. Detailed assessment of the geochemical partitioning of Ba in sediments and the lithogenic end-member allows appropriate correction of the bulk Ba content and determination of the Baxs content of sediments and suspended particles. The upper water column distribution of Baxs is extremely heterogeneous spatially and temporally. Organic carbon/Baxs ratios in deep traps from the Fe fertilized region are similar to other oceanic settings allowing quantification of the inferred carbon export based on established algorithms. There appears to be some decoupling of POC and Ba export in the Fe limited region south of the Plateau. The export production across the Crozet Plateau inferred from the Baxs sedimentary proxy indicates that the Fe fertilized area to the north of the Plateau experiences enhanced export relative to equivalent Southern Ocean settings throughout the Holocene and that this influence may also have impacted the site to the south for significant periods. This interpretation is corroborated by alternative productivity proxies (opal accumulation, 231Paxs/230Thxs). Baxs can be used to quantify export production in complex settings such as naturally Fe-fertilized (volcanoclastic) areas, providing appropriate lithogenic correction is undertaken, and sediment focusing is corrected for along with evaluation of barite preservation.

  3. Fluvial carbon export from a lowland Amazonian rainforest in relation to atmospheric fluxes

    NASA Astrophysics Data System (ADS)

    Vihermaa, Leena E.; Waldron, Susan; Domingues, Tomas; Grace, John; Cosio, Eric G.; Limonchi, Fabian; Hopkinson, Chris; da Rocha, Humberto Ribeiro; Gloor, Emanuel

    2016-12-01

    We constructed a whole carbon budget for a catchment in the Western Amazon Basin, combining drainage water analyses with eddy covariance (EC) measured terrestrial CO2 fluxes. As fluvial C export can represent permanent C export it must be included in assessments of whole site C balance, but it is rarely done. The footprint area of the flux tower is drained by two small streams ( 5-7 km2) from which we measured the dissolved inorganic carbon (DIC), dissolved organic carbon (DOC), particulate organic carbon (POC) export, and CO2 efflux. The EC measurements showed the site C balance to be +0.7 ± 9.7 Mg C ha-1 yr-1 (a source to the atmosphere) and fluvial export was 0.3 ± 0.04 Mg C ha-1 yr-1. Of the total fluvial loss 34% was DIC, 37% DOC, and 29% POC. The wet season was most important for fluvial C export. There was a large uncertainty associated with the EC results and with previous biomass plot studies (-0.5 ± 4.1 Mg C ha-1 yr-1); hence, it cannot be concluded with certainty whether the site is C sink or source. The fluvial export corresponds to only 3-7% of the uncertainty related to the site C balance; thus, other factors need to be considered to reduce the uncertainty and refine the estimated C balance. However, stream C export is significant, especially for almost neutral sites where fluvial loss may determine the direction of the site C balance. The fate of C downstream then dictates the overall climate impact of fluvial export.

  4. 21 CFR 1312.22 - Application for export permit.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 9 2010-04-01 2010-04-01 false Application for export permit. 1312.22 Section... EXPORTATION OF CONTROLLED SUBSTANCES Exportation of Controlled Substances § 1312.22 Application for export permit. (a) An application for a permit to export controlled substances shall be made on DEA Form 161...

  5. 19 CFR 191.73 - Export summary procedure.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Export summary procedure. 191.73 Section 191.73... TREASURY (CONTINUED) DRAWBACK Exportation and Destruction § 191.73 Export summary procedure. (a) General. The export summary procedure consists of a Chronological Summary of Exports used to support a drawback...

  6. 19 CFR 10.430 - Export requirements.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Export requirements. 10.430 Section 10.430 Customs... Export Requirements § 10.430 Export requirements. (a) Submission of certification to CBP. An exporter or producer in the United States that signs a certification of origin for a good exported from the United...

  7. 7 CFR 1488.9a - Evidence of export for commodities delivered before export.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... COMMODITIES Financing of Export Sales of Agricultural Commodities From Private Stocks Under CCC Export Credit... financial period is 12 months or less, the exporter shall furnish a certification to the Treasurer, CCC... Assistant Treasurer, CCC, certifying that the commodities have been exported. The certification must include...

  8. 7 CFR 1493.110 - Notice of default and claims for loss.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... CORPORATION, DEPARTMENT OF AGRICULTURE EXPORT PROGRAMS CCC EXPORT CREDIT GUARANTEE PROGRAMS CCC Export Credit Guarantee Program (GSM-102) and CCC Intermediate Export Credit Guarantee Program (GSM-103) Operations § 1493... related obligation, the exporter or the exporter's assignee must submit a notice of default to CCC as soon...

  9. 7 CFR 1493.110 - Notice of default and claims for loss.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... CORPORATION, DEPARTMENT OF AGRICULTURE EXPORT PROGRAMS CCC EXPORT CREDIT GUARANTEE PROGRAMS CCC Export Credit Guarantee Program (GSM-102) and CCC Intermediate Export Credit Guarantee Program (GSM-103) Operations § 1493... related obligation, the exporter or the exporter's assignee must submit a notice of default to CCC as soon...

  10. 7 CFR 1488.9a - Evidence of export for commodities delivered before export.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... COMMODITIES Financing of Export Sales of Agricultural Commodities From Private Stocks Under CCC Export Credit... financial period is 12 months or less, the exporter shall furnish a certification to the Treasurer, CCC... Assistant Treasurer, CCC, certifying that the commodities have been exported. The certification must include...

  11. 7 CFR 1488.9a - Evidence of export for commodities delivered before export.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... COMMODITIES Financing of Export Sales of Agricultural Commodities From Private Stocks Under CCC Export Credit... financial period is 12 months or less, the exporter shall furnish a certification to the Treasurer, CCC... Assistant Treasurer, CCC, certifying that the commodities have been exported. The certification must include...

  12. 7 CFR 1493.110 - Notice of default and claims for loss.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... CORPORATION, DEPARTMENT OF AGRICULTURE EXPORT PROGRAMS CCC EXPORT CREDIT GUARANTEE PROGRAMS CCC Export Credit Guarantee Program (GSM-102) and CCC Intermediate Export Credit Guarantee Program (GSM-103) Operations § 1493... related obligation, the exporter or the exporter's assignee must submit a notice of default to CCC as soon...

  13. RNA Export through the NPC in Eukaryotes.

    PubMed

    Okamura, Masumi; Inose, Haruko; Masuda, Seiji

    2015-03-20

    In eukaryotic cells, RNAs are transcribed in the nucleus and exported to the cytoplasm through the nuclear pore complex. The RNA molecules that are exported from the nucleus into the cytoplasm include messenger RNAs (mRNAs), ribosomal RNAs (rRNAs), transfer RNAs (tRNAs), small nuclear RNAs (snRNAs), micro RNAs (miRNAs), and viral mRNAs. Each RNA is transported by a specific nuclear export receptor. It is believed that most of the mRNAs are exported by Nxf1 (Mex67 in yeast), whereas rRNAs, snRNAs, and a certain subset of mRNAs are exported in a Crm1/Xpo1-dependent manner. tRNAs and miRNAs are exported by Xpot and Xpo5. However, multiple export receptors are involved in the export of some RNAs, such as 60S ribosomal subunit. In addition to these export receptors, some adapter proteins are required to export RNAs. The RNA export system of eukaryotic cells is also used by several types of RNA virus that depend on the machineries of the host cell in the nucleus for replication of their genome, therefore this review describes the RNA export system of two representative viruses. We also discuss the NPC anchoring-dependent mRNA export factors that directly recruit specific genes to the NPC.

  14. RNA Export through the NPC in Eukaryotes

    PubMed Central

    Okamura, Masumi; Inose, Haruko; Masuda, Seiji

    2015-01-01

    In eukaryotic cells, RNAs are transcribed in the nucleus and exported to the cytoplasm through the nuclear pore complex. The RNA molecules that are exported from the nucleus into the cytoplasm include messenger RNAs (mRNAs), ribosomal RNAs (rRNAs), transfer RNAs (tRNAs), small nuclear RNAs (snRNAs), micro RNAs (miRNAs), and viral mRNAs. Each RNA is transported by a specific nuclear export receptor. It is believed that most of the mRNAs are exported by Nxf1 (Mex67 in yeast), whereas rRNAs, snRNAs, and a certain subset of mRNAs are exported in a Crm1/Xpo1-dependent manner. tRNAs and miRNAs are exported by Xpot and Xpo5. However, multiple export receptors are involved in the export of some RNAs, such as 60S ribosomal subunit. In addition to these export receptors, some adapter proteins are required to export RNAs. The RNA export system of eukaryotic cells is also used by several types of RNA virus that depend on the machineries of the host cell in the nucleus for replication of their genome, therefore this review describes the RNA export system of two representative viruses. We also discuss the NPC anchoring-dependent mRNA export factors that directly recruit specific genes to the NPC. PMID:25802992

  15. Transport of dissolved nutrients and chlorophyll a in a tropical estuary, southwest coast of India.

    PubMed

    Lallu, K R; Fausia, K H; Vinita, J; Balachandran, K K; Naveen Kumar, K R; Rehitha, T V

    2014-08-01

    Intra-tidal variability in the transport of materials through the Cochin estuary was studied over successive spring and neap tides to estimate the export fluxes of nutrients and chlorophyll a into the adjoining coastal zone. The results showed that there was a substantial increase in the freshwater flow into the estuary following heavy rains (~126 mm) prior to the spring tide observations. The estuary responded accordingly with a relatively larger export through the Cochin inlet during spring tide over neap tide. Despite an increased freshwater discharge during spring tide, the export fluxes of phosphate and ammonia were high during neap tide due to their input into the estuary through anthropogenic activities. The significance of this study is that the export fluxes from the Cochin estuary could be a major factor sustaining the spectacular monsoon fishery along the southwest coast of India.

  16. Seasonal exports of phosphorus from intensively fertilised nested grassland catchments.

    PubMed

    Lewis, Ciaran; Rafique, Rashad; Foley, Nelius; Leahy, Paul; Morgan, Gerard; Albertson, John; Kumar, Sandeep; Kiely, Gerard

    2013-09-01

    We carried out a one year (2002) study of phosphorus (P) loss from soil to water in three nested grassland catchments with known P input in chemical fertilizer and animal liquid slurry applications. Chemical fertilizer was applied to the grasslands between March and September and animal slurry was applied over the twelve months. The annual chemical P fertilizer applications for the 17 and 211 ha catchments were 16.4 and 23.7 kg P/ha respectively and the annual slurry applications were 10.7 and 14.0 kg P/ha, respectively. The annual total phosphorus (TP) export in stream-flow was 2.61, 2.48 and 1.61 kg P/ha for the 17, 211 and 1524 ha catchments, respectively, compared with a maximum permissible (by regulation) annual export of ca. 0.35 kg P/ha. The export rate (ratio of P export to P in land applications) was 9.6% and 6.6% from the 17 and 211 ha catchments, respectively. On average, 70% of stream flow and 85% of the P export occurred during the five wet months (October to February) indicating that when precipitation is much greater than evaporation, the hydrological conditions are most favourable for P export. However the soil quality and land use history may vary the results. Particulate P made up 22%, 43% and 37% of the TP export at the 17, 211 and 1524 ha catchment areas, respectively. As the chemical fertilizer was spread during the grass growth months (March to September), it has less immediate impact on stream water quality than the slurry applications. We also show that as the catchment scale increases, the P concentrations and P export decrease, confirming dilution due to increasing rural catchment size. In the longer term, the excess P from fertilizer maintains high soil P levels, an antecedent condition favourable to P loss from soil to water. This study confirms the significant negative water quality impact of excess P applications, particularly liquid animal slurry applications in wet winter months. The findings suggest that restricted P application in wet months can largely reduce the P losses from soil to water.

  17. The role of hydrology in annual organic carbon loads and terrestrial organic matter export from a midwestern agricultural watershed

    NASA Astrophysics Data System (ADS)

    Dalzell, Brent J.; Filley, Timothy R.; Harbor, Jon M.

    2007-03-01

    Defining the control that hydrology exerts on organic carbon (OC) export at the watershed scale is important for understanding how the source and quantity of OC in streams and rivers is influenced by climate change or by landscape drainage. To this end, molecular (lignin phenol), stable carbon isotope, and dissolved organic carbon (DOC) data were collected over a range of flow conditions to examine the influence of hydrology on annual OC export from an 850 km 2 Midwestern United States agricultural watershed located in west central Indiana. In years 2002 and 2003, modeled annual DOC loads were 19.5 and 14.1 kg ha -1yr -1, while 71% and 85%, respectively, of the total annual OC was exported in flow events occurring during less than 20% of that time. These results highlight the importance of short-duration, high-discharge events (common in smaller watersheds) in controlling annual OC export. Based on reported increases in annual stream discharge coupled with current estimates of DOC export, annual DOC loads in this watershed may have increased by up to 40% over the past 50 years. Molecular (lignin phenol) characterization of quantity and relative degradation state of terrestrial OC shows as much temporal variability of lignin parameters (in high molecular weight dissolved organic carbon) in this one watershed as that demonstrated in previously published studies of dissolved organic matter in the Mississippi and Amazon Rivers. These results suggest that hydrologic variability is at least as important in determining the nature and extent of OC export as geographic variability. Moreover, molecular and bulk stable carbon isotope data from high molecular weight dissolved organic carbon and colloidal organic carbon showed that increased stream flow from the study watershed was responsible for increased export of agriculturally derived OC. When considered in the context of results from other studies that show the importance of flood events and in-stream processing of terrestrial organic carbon, our results show how hydrologic variability in smaller watersheds can reflect landscape-scale carbon dynamics in ways that cannot necessarily be measured at the outlets of large rivers due to multiple source signals and attenuated hydrology.

  18. Shifts in stream hydrochemistry in responses to typhoon and non-typhoon precipitation

    NASA Astrophysics Data System (ADS)

    Chang, Chung-Te; Huang, -Chuan, Jr.; Wang, Lixin; Shih, Yu-Ting; Lin, Teng-Chiu

    2018-04-01

    Climate change is projected to increase the intensity and frequency of extreme climatic events such as tropical cyclones. However, few studies have examined the responses of hydrochemical processes to climate extremes. To fill this knowledge gap, we compared the relationship between stream discharge and ion input-output budget during typhoon and non-typhoon periods in four subtropical mountain watersheds with different levels of agricultural land cover in northern Taiwan. The results indicated that the high predictability of ion input-output budgets using stream discharge during the non-typhoon period largely disappeared during the typhoon periods. For ions such as Na+, NH4+, and PO43-, the typhoon period and non-typhoon period exhibited opposite discharge-budget relationships. In other cases, the discharge-budget relationship was driven by the typhoon period, which consisted of only 7 % of the total time period. The striking differences in the discharge-ion budget relationship between the two periods likely resulted from differences in the relative contributions of surface runoff, subsurface runoff and groundwater, which had different chemical compositions, to stream discharge between the two periods. Watersheds with a 17-22 % tea plantation cover showed large increases in NO3- export with increases in stream discharge. In contrast, watersheds with 93-99 % forest cover showed very mild or no increases in NO3- export with increases in discharge and very low levels of NO3- export even during typhoon storms. The results suggest that even mild disruption of the natural vegetation could largely alter hydrochemical processes. Our study clearly illustrates significant shifts in hydrochemical responses between regular and typhoon precipitation. We propose that hydrological models should separate hydrochemical processes into regular and extreme conditions to better capture the whole spectrum of hydrochemical responses to a variety of climate conditions.

  19. Estimating the production, consumption and export of cannabis: The Dutch case.

    PubMed

    van der Giessen, Mark; van Ooyen-Houben, Marianne M J; Moolenaar, Debora E G

    2016-05-01

    Quantifying an illegal phenomenon like a drug market is inherently complex due to its hidden nature and the limited availability of reliable information. This article presents findings from a recent estimate of the production, consumption and export of Dutch cannabis and discusses the opportunities provided by, and limitations of, mathematical models for estimating the illegal cannabis market. The data collection consisted of a comprehensive literature study, secondary analyses on data from available registrations (2012-2014) and previous studies, and expert opinion. The cannabis market was quantified with several mathematical models. The data analysis included a Monte Carlo simulation to come to a 95% interval estimate (IE) and a sensitivity analysis to identify the most influential indicators. The annual production of Dutch cannabis was estimated to be between 171 and 965tons (95% IE of 271-613tons). The consumption was estimated to be between 28 and 119tons, depending on the inclusion or exclusion of non-residents (95% IE of 51-78tons or 32-49tons respectively). The export was estimated to be between 53 and 937tons (95% IE of 206-549tons or 231-573tons, respectively). Mathematical models are valuable tools for the systematic assessment of the size of illegal markets and determining the uncertainty inherent in the estimates. The estimates required the use of many assumptions and the availability of reliable indicators was limited. This uncertainty is reflected in the wide ranges of the estimates. The estimates are sensitive to 10 of the 45 indicators. These 10 account for 86-93% of the variation found. Further research should focus on improving the variables and the independence of the mathematical models. Copyright © 2016 Elsevier B.V. All rights reserved.

  20. Runoff changes have a land cover specific effect on the seasonal fluxes of terminal electron acceptors in the boreal catchments.

    PubMed

    Mattsson, Tuija; Lehtoranta, Jouni; Ekholm, Petri; Palviainen, Marjo; Kortelainen, Pirkko

    2017-12-01

    Climate change influences the volume and seasonal distribution of runoff in the northern regions. Here, we study how the seasonal variation in the runoff affects the concentrations and export of terminal electron acceptors (i.e. TEAs: NO 3 , Mn, Fe and SO 4 ) in different boreal land-cover classes. Also, we make a prediction how the anticipated climate change induced increase in runoff will alter the export of TEAs in boreal catchments. Our results show that there is a strong positive relationship between runoff and the concentration of NO 3 -N, Mn and Fe in agricultural catchments. In peaty catchments, the relationship is poorer and the concentrations of TEAs tend to decrease with increasing runoff. In forested catchments, the correlation between runoff and TEA concentrations was weak. In most catchments, the concentrations of SO 4 decrease with an increase in runoff regardless of the land cover or season. The wet years export much higher amounts of TEAs than the dry years. In southern agricultural catchments, the wet years increased the TEA export for both spring (January-May) and autumn (September-December) periods, while in the peaty and forested catchments in eastern and northern Finland the export only increased in the autumn. Our predictions for the year 2099 indicate that the export of TEAs will increase especially from agricultural but also from forested catchments. Additionally, the predictions show an increase in the export of Fe and SO 4 for all the catchments for the autumn. Thus, the climate induced change in the runoff regime is likely to alter the exported amount of TEAs and the timing of the export downstream. The changes in the amounts and timing in the export of TEAs have a potential to modify the mineralization pathways in the receiving water bodies, with feedbacks in the cycling of C, nutrients and metals in aquatic ecosystems. Copyright © 2017 Elsevier B.V. All rights reserved.

  1. A biochemical framework for eIF4E-dependent mRNA export and nuclear recycling of the export machinery.

    PubMed

    Volpon, Laurent; Culjkovic-Kraljacic, Biljana; Sohn, Hye Seon; Blanchet-Cohen, Alexis; Osborne, Michael J; Borden, Katherine L B

    2017-06-01

    The eukaryotic translation initiation factor eIF4E acts in the nuclear export and translation of a subset of mRNAs. Both of these functions contribute to its oncogenic potential. While the biochemical mechanisms that underlie translation are relatively well understood, the molecular basis for eIF4E's role in mRNA export remains largely unexplored. To date, over 3000 transcripts, many encoding oncoproteins, were identified as potential nuclear eIF4E export targets. These target RNAs typically contain a ∼50-nucleotide eIF4E sensitivity element (4ESE) in the 3' UTR and a 7-methylguanosine cap on the 5' end. While eIF4E associates with the cap, an unknown factor recognizes the 4ESE element. We previously identified cofactors that functionally interacted with eIF4E in mammalian cell nuclei including the leucine-rich pentatricopeptide repeat protein LRPPRC and the export receptor CRM1/XPO1. LRPPRC simultaneously interacts with both eIF4E bound to the 5' mRNA cap and the 4ESE element in the 3' UTR. In this way, LRPPRC serves as a specificity factor to recruit 4ESE-containing RNAs within the nucleus. Further, we show that CRM1 directly binds LRPPRC likely acting as the export receptor for the LRPPRC-eIF4E-4ESE RNA complex. We also found that Importin 8, the nuclear importer for cap-free eIF4E, imports RNA-free LRPPRC, potentially providing both coordinated nuclear recycling of the export machinery and an important surveillance mechanism to prevent futile export cycles. Our studies provide the first biochemical framework for the eIF4E-dependent mRNA export pathway. © 2017 Volpon et al.; Published by Cold Spring Harbor Laboratory Press for the RNA Society.

  2. Estimating the contribution of strong daily export events to total pollutant export from the United States in summer

    NASA Astrophysics Data System (ADS)

    Fang, Yuanyuan; Fiore, Arlene M.; Horowitz, Larry W.; Gnanadesikan, Anand; Levy, Hiram; Hu, Yongtao; Russell, Armistead G.

    2009-12-01

    While the export of pollutants from the United States exhibits notable variability from day to day and is often considered to be "episodic," the contribution of strong daily export events to total export has not been quantified. We use carbon monoxide (CO) as a tracer of anthropogenic pollutants in the Model of OZone And Related Tracers (MOZART) to estimate this contribution. We first identify the major export pathway from the United States to be through the northeast boundary (24-48°N along 67.5°W and 80-67.5°W along 48°N), and then analyze 15 summers of daily CO export fluxes through this boundary. These daily CO export fluxes have a nearly Gaussian distribution with a mean of 1100 Gg CO day-1 and a standard deviation of 490 Gg CO day-1. To focus on the synoptic variability, we define a "synoptic background" export flux equal to the 15 day moving average export flux and classify strong export days according to their fluxes relative to this background. As expected from Gaussian statistics, 16% of summer days are "strong export days," classified as those days when the CO export flux exceeds the synoptic background by one standard deviation or more. Strong export days contributes 25% to the total export, a value determined by the relative standard deviation of the CO flux distribution. Regressing the anomalies of the CO export flux through the northeast U.S. boundary relative to the synoptic background on the daily anomalies in the surface pressure field (also relative to a 15 day running mean) suggests that strong daily export fluxes are correlated with passages of midlatitude cyclones over the Gulf of Saint Lawrence. The associated cyclonic circulation and Warm Conveyor Belts (WCBs) that lift surface pollutants over the northeastern United States have been shown previously to be associated with long-range transport events. Comparison with observations from the 2004 INTEX-NA field campaign confirms that our model captures the observed enhancements in CO outflow and resolves the processes associated with cyclone passages on strong export days. "Moderate export days," defined as days when the CO flux through the northeast boundary exceeds the 15 day running mean by less than one standard deviation, represent an additional 34% of summer days and 40% of total export. These days are also associated with migratory midlatitude cyclones. The remaining 35% of total export occurs on "weak export days" (50% of summer days) when high pressure anomalies occur over the Gulf of Saint Lawrence. Our findings for summer also apply to spring, when the U.S. pollutant export is typically strongest, with similar contributions to total export and associated meteorology on strong, moderate and weak export days. Although cyclone passages are the primary driver for strong daily export events, export during days without cyclone passages also makes a considerable contribution to the total export and thereby to the global pollutant budget.

  3. “It’s my blood”: ethical complexities in the use, storage and export of biological samples: perspectives from South African research participants

    PubMed Central

    2014-01-01

    Background The use of biological samples in research raises a number of ethical issues in relation to consent, storage, export, benefit sharing and re-use of samples. Participant perspectives have been explored in North America and Europe, with only a few studies reported in Africa. The amount of research being conducted in Africa is growing exponentially with volumes of biological samples being exported from the African continent. In order to investigate the perspectives of African research participants, we conducted a study at research sites in the Western Cape and Gauteng, South Africa. Methods Data were collected using a semi-structured questionnaire that captured both quantitative and qualitative information at 6 research sites in South Africa. Interviews were conducted in English and Afrikaans. Data were analysed both quantitatively and qualitatively. Results Our study indicates that while the majority of participants were supportive of providing samples for research, serious concerns were voiced about future use, benefit sharing and export of samples. While researchers view the provision of biosamples as a donation, participants believe that they still have ownership rights and are therefore in favour of benefit sharing. Almost half of the participants expressed a desire to be re-contacted for consent for future use of their samples. Interesting opinions were expressed with respect to export of samples. Conclusions Eliciting participant perspectives is an important part of community engagement in research involving biological sample collection, export, storage and future use. A tiered consent process appears to be more acceptable to participants in this study. Eliciting opinions of researchers and research ethics committee (REC) members would contribute multiple perspectives. Further research is required to interrogate the concept of ownership and the consent process in research involving biological samples. PMID:24447822

  4. Carbon dioxide emission and economic growth of China-the role of international trade.

    PubMed

    Boamah, Kofi Baah; Du, Jianguo; Bediako, Isaac Asare; Boamah, Angela Jacinta; Abdul-Rasheed, Alhassan Alolo; Owusu, Samuel Mensah

    2017-05-01

    This study investigates the role of international trade in mitigating carbon dioxide emission as a nation economically advances. This study disaggregated the international trade into total exports and total imports. A multivariate model framework was estimated for the time series data for the period of 1970-2014. The quantile regression detected all the essential relationship, which hitherto, the traditional ordinary least squares could not capture. A cointegration relationship was confirmed using the Johansen cointegration model. The findings of the Granger causality revealed the presence of a uni-directional Granger causality running from energy consumption to economic growth; from import to economic growth; from imports to exports; and from urbanisation to economic growth, exports and imports. Our study established the presence of long-run relationships amongst carbon dioxide emission, economic growth, energy consumption, imports, exports and urbanisation. A bootstrap method was further utilised to reassess the evidence of the Granger causality, of which the results affirmed the Granger causality in the long run. This study confirmed a long-run N-shaped relationship between economic growth and carbon emission, under the estimated cubic environmental Kuznet curve framework, from the perspective of China. The recommendation therefore is that China as export leader should transform its trade growth mode by reducing the level of carbon dioxide emission and strengthening its international cooperation as it embraces more environmental protectionisms.

  5. COPII-Dependent ER Export: A Critical Component of Insulin Biogenesis and β-Cell ER Homeostasis.

    PubMed

    Fang, Jingye; Liu, Ming; Zhang, Xuebao; Sakamoto, Takeshi; Taatjes, Douglas J; Jena, Bhanu P; Sun, Fei; Woods, James; Bryson, Tim; Kowluru, Anjaneyulu; Zhang, Kezhong; Chen, Xuequn

    2015-08-01

    Pancreatic β-cells possess a highly active protein synthetic and export machinery in the endoplasmic reticulum (ER) to accommodate the massive production of proinsulin. ER homeostasis is vital for β-cell functions and is maintained by the delicate balance between protein synthesis, folding, export, and degradation. Disruption of ER homeostasis by diabetes-causing factors leads to β-cell death. Among the 4 components to maintain ER homeostasis in β-cells, the role of ER export in insulin biogenesis is the least understood. To address this knowledge gap, the present study investigated the molecular mechanism of proinsulin ER export in MIN6 cells and primary islets. Two inhibitory mutants of the secretion-associated RAS-related protein (Sar)1 small GTPase, known to specifically block coat protein complex II (COPII)-dependent ER export, were overexpressed in β-cells using recombinant adenoviruses. Results from this approach, as well as small interfering RNA-mediated Sar1 knockdown, demonstrated that defective Sar1 function blocked proinsulin ER export and abolished its conversion to mature insulin in MIN6 cells, isolated mouse, and human islets. It is further revealed, using an in vitro vesicle formation assay, that proinsulin was packaged into COPII vesicles in a GTP- and Sar1-dependent manner. Blockage of COPII-dependent ER exit by Sar1 mutants strongly induced ER morphology change, ER stress response, and β-cell apoptosis. These responses were mediated by the PKR (double-stranded RNA-dependent kinase)-like ER kinase (PERK)/eukaryotic translation initiation factor 2α (p-eIF2α) and inositol-requiring protein 1 (IRE1)/x-box binding protein 1 (Xbp1) pathways but not via activating transcription factor 6 (ATF6). Collectively, results from the study demonstrate that COPII-dependent ER export plays a vital role in insulin biogenesis, ER homeostasis, and β-cell survival.

  6. Sharing Health Big Data for Research - A Design by Use Cases: The INSHARE Platform Approach.

    PubMed

    Bouzillé, Guillaume; Westerlynck, Richard; Defossez, Gautier; Bouslimi, Dalel; Bayat, Sahar; Riou, Christine; Busnel, Yann; Le Guillou, Clara; Cauvin, Jean-Michel; Jacquelinet, Christian; Pladys, Patrick; Oger, Emmanuel; Stindel, Eric; Ingrand, Pierre; Coatrieux, Gouenou; Cuggia, Marc

    2017-01-01

    Sharing and exploiting Health Big Data (HBD) allow tackling challenges: data protection/governance taking into account legal, ethical, and deontological aspects enables trust, transparent and win-win relationship between researchers, citizens, and data providers. Lack of interoperability: compartmentalized and syntactically/semantica heterogeneous data. INSHARE project using experimental proof of concept explores how recent technologies overcome such issues. Using 6 data providers, platform is designed via 3 steps to: (1) analyze use cases, needs, and requirements; (2) define data sharing governance, secure access to platform; and (3) define platform specifications. Three use cases - from 5 studies and 11 data sources - were analyzed for platform design. Governance derived from SCANNER model was adapted to data sharing. Platform architecture integrates: data repository and hosting, semantic integration services, data processing, aggregate computing, data quality and integrity monitoring, Id linking, multisource query builder, visualization and data export services, data governance, study management service and security including data watermarking.

  7. 21 CFR 1313.23 - Distribution of export declaration.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 9 2010-04-01 2010-04-01 false Distribution of export declaration. 1313.23... EXPORTATION OF LIST I AND LIST II CHEMICALS Exportation of Listed Chemicals § 1313.23 Distribution of export declaration. The required three copies of the listed chemical export declaration (DEA Form 486) will be...

  8. 7 CFR 1488.9 - Evidence of export.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Evidence of export. 1488.9 Section 1488.9 Agriculture... Export Sales of Agricultural Commodities From Private Stocks Under CCC Export Credit Sales Program (GSM-5) Documents Required for Financing § 1488.9 Evidence of export. (a) If the commodity is exported by rail or...

  9. 22 CFR 125.1 - Exports subject to this part.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... EXPORT OF TECHNICAL DATA AND CLASSIFIED DEFENSE ARTICLES § 125.1 Exports subject to this part. (a) The controls of this part apply to the export of technical data and the export of classified defense articles... to the controls of this subchapter. (b) A license for the export of technical data and the exemptions...

  10. Phosphorus Export Model Development in a Terminal Lake Basin using Concentration-Streamflow Relationship

    NASA Astrophysics Data System (ADS)

    Jeannotte, T.; Mahmood, T. H.; Matheney, R.; Hou, X.

    2017-12-01

    Nutrient export to streams and lakes by anthropogenic activities can lead to eutrophication and degradation of surface water quality. In Devils Lake, ND, the only terminal lake in the Northern Great Plains, the algae boom is of great concern due to the recent increase in streamflow and consequent rise in phosphorus (P) export from prairie agricultural fields. However, to date, very few studies explored the concentration (c) -streamflow (q) relationship in the headwater catchments of the Devils Lake basin. A robust watershed-scale quantitative framework would aid understanding of the c-q relationship, simulating P concentration and load. In this study, we utilize c-q relationships to develop a simple model to estimate phosphorus concentration and export from two headwater catchments of different size (Mauvais Coulee: 1032 km2 and Trib 3: 160 km2) draining to Devils Lake. Our goal is to link the phosphorus export model with a physically based hydrologic model to identify major drivers of phosphorus export. USGS provided the streamflow measurements, and we collected water samples (filtered and unfiltered) three times daily during the spring snowmelt season (March 31, 2017- April 12, 2017) at the outlets of both headwater catchments. Our results indicate that most P is dissolved and very little is particulate, suggesting little export of fine-grained sediment from agricultural fields. Our preliminary analyses in the Mauvais Coulee catchment show a chemostatic c-q relationship in the rising limb of the hydrograph, while the recession limb shows a linear and positive c-q relationship. The poor correlation in the rising limb of the hydrograph suggests intense flushing of P by spring snowmelt runoff. Flushing then continues in the recession limb of the hydrograph, but at a more constant rate. The estimated total P load for the Mauvais Coulee basin is 193 kg/km2, consistent with other catchments of similar size across the Red River of the North basin to the east. We expect our P measurements at Trib 3 basin, a considerably smaller basin compared to Mauvais Coulee, provide an opportunity to investigate the impacts of watershed scales on nutrient exports and c-q relationship. Finally, our study will lay a strong foundation for future nutrient modeling studies in the Devils Lake basin.

  11. Impacts of fertilization on water quality of a drained pine plantation: a worst case scenario.

    PubMed

    Beltran, Bray J; Amatya, Devendra M; Youssef, Mohamed; Jones, Martin; Callahan, Timothy J; Skaggs, R Wayne; Nettles, Jami E

    2010-01-01

    Intensive plantation forestry will be increasingly important in the next 50 yr to meet the high demand for domestic wood in the United States. However, forest management practices can substantially influence downstream water quality and ecology. This study analyses, the effect of fertilization on effluent water quality of a low gradient drained coastal pine plantation in Carteret County, North Carolina using a paired watershed approach. The plantation consists of three watersheds, two mature (31-yr) and one young (8-yr) (age at treatment). One of the mature watersheds was commercially thinned in 2002. The mature unthinned watershed was designated as the control. The young and mature-thinned watersheds were fertilized at different rates with Arborite (Encee Chemical Sales, Inc., Bridgeton, NC), and boron. The outflow rates and nutrient concentrations in water drained from each of the watersheds were measured. Nutrient concentrations and loadings were analyzed using general linear models (GLM). Three large storm events occurred within 47 d of fertilization, which provided a worst case scenario for nutrient export from these watersheds to the receiving surface waters. Results showed that average nutrient concentrations soon after fertilization were significantly (alpha = 0.05) higher on both treatment watersheds than during any other period during the study. This increase in nutrient export was short lived and nutrient concentrations and loadings were back to prefertilization levels as soon as 3 mo after fertilization. Additionally, the mature-thinned watershed presented higher average nutrient concentrations and loadings when compared to the young watershed, which received a reduced fertilizer rate than the mature-thinned watershed.

  12. Biological Dual-Use Research and Synthetic Biology of Yeast.

    PubMed

    Cirigliano, Angela; Cenciarelli, Orlando; Malizia, Andrea; Bellecci, Carlo; Gaudio, Pasquale; Lioj, Michele; Rinaldi, Teresa

    2017-04-01

    In recent years, the publication of the studies on the transmissibility in mammals of the H5N1 influenza virus and synthetic genomes has triggered heated and concerned debate within the community of scientists on biological dual-use research; these papers have raised the awareness that, in some cases, fundamental research could be directed to harmful experiments, with the purpose of developing a weapon that could be used by a bioterrorist. Here is presented an overview regarding the dual-use concept and its related international agreements which underlines the work of the Australia Group (AG) Export Control Regime. It is hoped that the principles and activities of the AG, that focuses on export control of chemical and biological dual-use materials, will spread and become well known to academic researchers in different countries, as they exchange biological materials (i.e. plasmids, strains, antibodies, nucleic acids) and scientific papers. To this extent, and with the aim of drawing the attention of the scientific community that works with yeast to the so called Dual-Use Research of Concern, this article reports case studies on biological dual-use research and discusses a synthetic biology applied to the yeast Saccharomyces cerevisiae, namely the construction of the first eukaryotic synthetic chromosome of yeast and the use of yeast cells as a factory to produce opiates. Since this organism is considered harmless and is not included in any list of biological agents, yeast researchers should take simple actions in the future to avoid the sharing of strains and advanced technology with suspicious individuals.

  13. Fuel of the Bacterial Flagellar Type III Protein Export Apparatus.

    PubMed

    Minamino, Tohru; Kinoshita, Miki; Namba, Keiichi

    2017-01-01

    The flagellar type III export apparatus utilizes ATP and proton motive force (PMF) across the cytoplasmic membrane as the energy sources and transports flagellar component proteins from the cytoplasm to the distal growing end of the growing structure to construct the bacterial flagellum beyond the cellular membranes. The flagellar type III export apparatus coordinates flagellar protein export with assembly by ordered export of substrates to parallel with their order of the assembly. The export apparatus is composed of a PMF-driven transmembrane export gate complex and a cytoplasmic ATPase complex. Since the ATPase complex is dispensable for flagellar protein export, PMF is the primary fuel for protein unfolding and translocation. Interestingly, the export gate complex can also use sodium motive force across the cytoplasmic membrane in addition to PMF when the ATPase complex does not work properly. Here, we describe experimental protocols, which have allowed us to identify the export substrate class and the primary fuel of the flagellar type III protein export apparatus in Salmonella enterica serovar Typhimurium.

  14. 5-methylcytosine promotes mRNA export — NSUN2 as the methyltransferase and ALYREF as an m5C reader

    PubMed Central

    Yang, Xin; Yang, Ying; Sun, Bao-Fa; Chen, Yu-Sheng; Xu, Jia-Wei; Lai, Wei-Yi; Li, Ang; Wang, Xing; Bhattarai, Devi Prasad; Xiao, Wen; Sun, Hui-Ying; Zhu, Qin; Ma, Hai-Li; Adhikari, Samir; Sun, Min; Hao, Ya-Juan; Zhang, Bing; Huang, Chun-Min; Huang, Niu; Jiang, Gui-Bin; Zhao, Yong-Liang; Wang, Hai-Lin; Sun, Ying-Pu; Yang, Yun-Gui

    2017-01-01

    5-methylcytosine (m5C) is a post-transcriptional RNA modification identified in both stable and highly abundant tRNAs and rRNAs, and in mRNAs. However, its regulatory role in mRNA metabolism is still largely unknown. Here, we reveal that m5C modification is enriched in CG-rich regions and in regions immediately downstream of translation initiation sites and has conserved, tissue-specific and dynamic features across mammalian transcriptomes. Moreover, m5C formation in mRNAs is mainly catalyzed by the RNA methyltransferase NSUN2, and m5C is specifically recognized by the mRNA export adaptor ALYREF as shown by in vitro and in vivo studies. NSUN2 modulates ALYREF's nuclear-cytoplasmic shuttling, RNA-binding affinity and associated mRNA export. Dysregulation of ALYREF-mediated mRNA export upon NSUN2 depletion could be restored by reconstitution of wild-type but not methyltransferase-defective NSUN2. Our study provides comprehensive m5C profiles of mammalian transcriptomes and suggests an essential role for m5C modification in mRNA export and post-transcriptional regulation. PMID:28418038

  15. 76 FR 66693 - President's Export Council: Meeting of the President's Export Council

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-27

    .... ACTION: Notice of an open meeting. SUMMARY: The President's Export Council will hold a meeting to discuss.... exports, jobs, and growth. DATES: November 16, 2011 at 9:30 a.m. (ET) ADDRESSES: The President's Export... on December 20, 1973 to advise the President on matters relating to U.S. export trade and report to...

  16. 50 CFR 23.53 - What are the requirements for obtaining a retrospective CITES document?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... certain specimens for personal use as specified in paragraph (d)(7) of this section. (2) The exporter or re-exporter must notify the Management Authority in the exporting or re-exporting country of the...) In general, except when the exporter or re-exporter and importer have demonstrated they were not...

  17. 21 CFR 1313.22 - Contents of export declaration.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 9 2010-04-01 2010-04-01 false Contents of export declaration. 1313.22 Section... EXPORTATION OF LIST I AND LIST II CHEMICALS Exportation of Listed Chemicals § 1313.22 Contents of export... quantitative threshold criteria established in § 1310.04(f) of this chapter may be exported if that chemical is...

  18. The export premium: why some logs are worth more abroad.

    Treesearch

    Donald F. Flora; Wendy J. McGinnis; Christine L. Lane

    1993-01-01

    For as long as logs have been exported from the Pacific Northwest, they seem to have been worth more offshore than in the domestic market. Five reasons for the export premium are the inconvenience of trade, quality, extra "haul and hassle," continuity in export arrangements, and export embargoes. A large and increasing differential remains between export and...

  19. 21 CFR 1312.23 - Issuance of export permit.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 9 2010-04-01 2010-04-01 false Issuance of export permit. 1312.23 Section 1312.23... CONTROLLED SUBSTANCES Exportation of Controlled Substances § 1312.23 Issuance of export permit. (a) The... regulation in § 1312.30 of this part be exported only pursuant to the issuance of an export permit. The...

  20. 76 FR 31584 - President's Export Council Subcommittee on Export Administration, Notice of Open Meeting...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-01

    ... DEPARTMENT OF COMMERCE Bureau of Industry and Security President's Export Council Subcommittee on Export Administration, Notice of Open Meeting; Correction: Meeting Time and Agenda The President's Export Council Subcommittee on Export Administration (PECSEA) will meet on June 9, 2011, 10 a.m., at the U.S. Department of Commerce, Herbert C. Hoove...

  1. Attribution of CO2 emissions from Brazilian deforestation to domestic and international drivers

    NASA Astrophysics Data System (ADS)

    Karstensen, J.; Peters, G.

    2011-12-01

    Efforts to address extensive deforestation to reduce climate change and save primary forests are taking place on a global scale. Whilst several studies have estimated the emissions occurring from deforestation in large rainforests, few studies have investigated the domestic and international drivers sustaining and increasing the deforestation rates. Brazil, having the largest rainforest in the world and one of the highest deforestation rates, is also currently one of the world's largest exporters of soybeans and beef. In this case study we establish the link between Brazilian deforestation and cattle and soybean production, and further attribute emissions to countries and economic sectors through export and import of Brazilian commodities. The emissions from deforestation can therefore be allocated to the countries and sectors consuming goods and services produced on deforested land in Brazil. A land-use change model and deforestation data is coupled with a carbon cycle model to create yearly emission estimates and different emission allocation schemes, depending on emission amortizations and discounting functions for past deforestation. We use an economic multi-regional input-output model (with 112 regions and 57 sectors) to distribute these emissions along agricultural trade routes, through domestic and international consumption in 2004. With our implementation we find that around 80 % of emissions from deforested land is due to cattle grazing, while agricultural transition effects suggests soy beans are responsible for about 20 % of the emissions occurring in 2004. Nearly tree quarters of the soy beans are consumed outside Brazil, of which China, Germany and France are the biggest consumers. Soy beans are consumed by a variety of sectors in the food industry. Brazil exports about 30 % of the cattle it produces, where Russia, USA and Germany are among the largest consumers. Cattle consumption mainly occurs in the meat sectors. In this study we estimate the CO2 emissions allocated to the consuming countries and economic sectors, to ultimately distribute responsibility and find the main drivers of Brazilian deforestation.

  2. Reengineering ribosome export.

    PubMed

    Lo, Kai-Yin; Johnson, Arlen W

    2009-03-01

    Large cargoes require multiple receptors for efficient transport through the nuclear pore complex. The 60S ribosomal subunit is one of the bulkiest transport cargoes, and in yeast three different receptors, Crm1, Mex67/Mtr2, and Arx1, collaborate in its export. However, only Crm1, recruited by the adapter Nmd3, appears to be conserved for 60S export in higher eukaryotes. We asked if export of the large subunit requires specific receptors. We made protein fusions between mutant Nmd3 and various export receptors. Surprisingly, fusions of Mex67, the tRNA exportin Los1, Mtr2, Cse1, or Msn5 to Nmd3, lacking its Crm1-dependent nuclear export signal (NES), all functioned in export. Furthermore, these chimeric proteins supported 60S export even in the presence of the Crm1 inhibitor leptomycin B, indicating that export was now independent of Crm1. These results suggest that there is not a requirement for a specific export receptor for the large subunit, as recruitment of any receptor will suffice. Finally we show that the addition of an NES directly to the 60S ribosomal subunit protein Rpl3 promotes export. These results imply remarkable flexibility in the export pathway for the 60S subunit and help explain how different export receptors could have evolved in different eukaryotic lineages.

  3. Reengineering Ribosome Export

    PubMed Central

    Lo, Kai-Yin

    2009-01-01

    Large cargoes require multiple receptors for efficient transport through the nuclear pore complex. The 60S ribosomal subunit is one of the bulkiest transport cargoes, and in yeast three different receptors, Crm1, Mex67/Mtr2, and Arx1, collaborate in its export. However, only Crm1, recruited by the adapter Nmd3, appears to be conserved for 60S export in higher eukaryotes. We asked if export of the large subunit requires specific receptors. We made protein fusions between mutant Nmd3 and various export receptors. Surprisingly, fusions of Mex67, the tRNA exportin Los1, Mtr2, Cse1, or Msn5 to Nmd3, lacking its Crm1-dependent nuclear export signal (NES), all functioned in export. Furthermore, these chimeric proteins supported 60S export even in the presence of the Crm1 inhibitor leptomycin B, indicating that export was now independent of Crm1. These results suggest that there is not a requirement for a specific export receptor for the large subunit, as recruitment of any receptor will suffice. Finally we show that the addition of an NES directly to the 60S ribosomal subunit protein Rpl3 promotes export. These results imply remarkable flexibility in the export pathway for the 60S subunit and help explain how different export receptors could have evolved in different eukaryotic lineages. PMID:19144820

  4. [Structure and function of the bacterial flagellar type III protein export system in Salmonella
].

    PubMed

    Minamino, Tohru

    2015-01-01

    The bacterial flagellum is a filamentous organelle that propels the bacterial cell body in liquid media. For construction of the bacterial flagellum beyond the cytoplasmic membrane, flagellar component proteins are transported by its specific protein export apparatus from the cytoplasm to the distal end of the growing flagellar structure. The flagellar export apparatus consists of a transmembrane export gate complex and a cytoplasmic ATPase ring complex. Flagellar substrate-specific chaperones bind to their cognate substrates in the cytoplasm and escort the substrates to the docking platform of the export gate. The export apparatus utilizes ATP and proton motive force across the cytoplasmic membrane as the energy sources to drive protein export and coordinates protein export with assembly by ordered export of substrates to parallel with their order of assembly. In this review, we summarize our current understanding of the structure and function of the flagellar protein export system in Salmonella enterica serovar Typhimurium.

  5. Stationarity and Inequality from the Mississippi to the Kissimmee: Climatic Control of Temporal Patterns in Catchment Discharge and Solute Export

    NASA Astrophysics Data System (ADS)

    Jawitz, J. W.

    2011-12-01

    What are the relative contributions of climatic variability, land management, and local geomorphology in determining the temporal dynamics of streamflow and the export of solutes from watersheds to receiving water bodies? A simple analytical framework is introduced for characterizing the temporal inequality of stream discharge and solute export from catchments using Lorenz diagrams and the associated Gini coefficient. These descriptors are used to illustrate a broad range of observed flow variability with a synthesis of multi-decadal flow data from 22 rivers in Florida. The analytical framework is extended to comprehensively link variability in flows and loads to climatically-driven inputs in terms of these inequality-based metrics. Further, based on a synthesis of data from the basins of the Baltic Sea, the Mississippi River, the Kissimmee River and other tributaries to Lake Okeechobee, FL, it is shown that inter-annual variations in exported loads for geogenic constituents, and for total N and total P, are dominantly controlled by discharge. Emergence of this consistent pattern across diverse managed catchments is attributed to the anthropogenic legacy of accumulated nutrient sources generating memory, similar to ubiquitously present sources for geogenic constituents. Multi-decadal phosphorus load data from 4 of the primary tributaries to Lake Okeechobee and sodium and nitrate load data from 9 of the Hubbard Brook, NH long-term study site catchments are used to examine the relation between inequality of climatic inputs, river flows and catchment loads. The intra-annual loads to Lake Okeechobee are shown to be highly unequal, such that 90% of annual load is delivered in as little as 15% of the time. Analytic expressions are developed for measures of inequality in terms of parameters of the lognormal distribution under general conditions that include intermittency. In cases where climatic variability is high compared to that of concentrations (chemostatic conditions), such as for P in the Lake Okeechobee basin and Na in Hubbard Brook, the temporal inequality of rainfall and flow are strong surrogates for load inequality. However, in cases where variability of concentrations is high compared to that of flows (chemodynamic conditions), such as for nitrate in the Hubbard Brook catchments, load inequality is greater than rainfall or flow inequality. The measured degree of correspondence between climatic, flow, and load inequality for these data sets are shown to be well described using the general inequality framework introduced here. Important implications are that (1) variations in hydro-climatic or anthropogenic forcing can be used to robustly predict inter-annual variations in flows and loads, (2) water quality problems in receiving inland and coastal waters may persist until the accumulated storages of nutrients have been substantially depleted, and (3) remedial measures designed to intercept or capture exported flows and loads must be designed with consideration of the intra-annual inequality.

  6. Iron Export through the Transporter Ferroportin 1 Is Modulated by the Iron Chaperone PCBP2*

    PubMed Central

    Yanatori, Izumi; Richardson, Des R.; Imada, Kiyoshi; Kishi, Fumio

    2016-01-01

    Ferroportin 1 (FPN1) is an iron export protein found in mammals. FPN1 is important for the export of iron across the basolateral membrane of absorptive enterocytes and across the plasma membrane of macrophages. The expression of FPN1 is regulated by hepcidin, which binds to FPN1 and then induces its degradation. Previously, we demonstrated that divalent metal transporter 1 (DMT1) interacts with the intracellular iron chaperone protein poly(rC)-binding protein 2 (PCBP2). Subsequently, PCBP2 receives iron from DMT1 and then disengages from the transporter. In this study, we investigated the function of PCBP2 in iron export. Mammalian genomes encode four PCBPs (i.e. PCBP1–4). Here, for the first time, we demonstrated using both yeast and mammalian cells that PCBP2, but not PCBP1, PCBP3, or PCBP4, binds with FPN1. Importantly, iron-loaded, but not iron-depleted, PCBP2 interacts with FPN1. The PCBP2-binding domain of FPN1 was identified in its C-terminal cytoplasmic region. The silencing of PCBP2 expression suppressed FPN1-dependent iron export from cells. These results suggest that FPN1 exports iron received from the iron chaperone PCBP2. Therefore, it was found that PCBP2 modulates cellular iron export, which is an important physiological process. PMID:27302059

  7. Nuclear egress of TDP-43 and FUS occurs independently of Exportin-1/CRM1.

    PubMed

    Ederle, Helena; Funk, Christina; Abou-Ajram, Claudia; Hutten, Saskia; Funk, Eva B E; Kehlenbach, Ralph H; Bailer, Susanne M; Dormann, Dorothee

    2018-05-04

    TDP-43 and FUS are nuclear proteins with multiple functions in mRNA processing. They play key roles in ALS (amyotrophic lateral sclerosis) and FTD (frontotemporal dementia), where they are partially lost from the nucleus and aggregate in the cytoplasm of neurons and glial cells. Defects in nucleocytoplasmic transport contribute to this pathology, hence nuclear import of both proteins has been studied in detail. However, their nuclear export routes remain poorly characterized and it is unclear whether aberrant nuclear export contributes to TDP-43 or FUS pathology. Here we show that predicted nuclear export signals in TDP-43 and FUS are non-functional and that both proteins are exported independently of the export receptor CRM1/Exportin-1. Silencing of Exportin-5 or the mRNA export factor Aly/REF, as well as mutations that abrogate RNA-binding do not impair export of TDP-43 and FUS. However, artificially enlarging TDP-43 or FUS impairs their nuclear egress, suggesting that they could leave the nucleus by passive diffusion. Finally, we found that inhibition of transcription causes accelerated nuclear egress of TDP-43, suggesting that newly synthesized RNA retains TDP-43 in the nucleus, limiting its egress into the cytoplasm. Our findings implicate reduced nuclear retention as a possible factor contributing to mislocalization of TDP-43 in ALS/FTD.

  8. A Quantitative Investigation of Stakeholder Variation in Training Program Evaluation.

    ERIC Educational Resources Information Center

    Michalski, Greg V.

    A survey was conducted to investigate variation in stakeholder perceptions of training results and evaluation within the context of a high-technology product development firm (the case organization). A scannable questionnaire survey booklet was developed and scanned data were exported and analyzed. Based on an achieved sample of 280 (70% response…

  9. 27 CFR 44.261 - To contiguous foreign countries.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... shipper's export declaration or, in the case of a shipment for the armed forces of the United States in... appropriate TTB officer. [T.D. 6961, 33 FR 9494, June 28, 1968. Redesignated at 40 FR 16835, Apr. 15, 1975, as amended by T.D. ATF-421, 64 FR 71926, Dec. 22, 1999] ...

  10. 27 CFR 44.261 - To contiguous foreign countries.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... shipper's export declaration or, in the case of a shipment for the armed forces of the United States in... appropriate TTB officer. [T.D. 6961, 33 FR 9494, June 28, 1968. Redesignated at 40 FR 16835, Apr. 15, 1975, as amended by T.D. ATF-421, 64 FR 71926, Dec. 22, 1999] ...

  11. 50 CFR 14.53 - Detention and refusal of clearance.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... origin of the wildlife has not been established (in such cases, the burden is upon the owner, importer, exporter, consignor, or consignee to establish such identity by scientific name to the species level or, if any subspecies is protected by the laws of this country or the country of origin to the subspecies...

  12. 50 CFR 14.53 - Detention and refusal of clearance.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... origin of the wildlife has not been established (in such cases, the burden is upon the owner, importer, exporter, consignor, or consignee to establish such identity by scientific name to the species level or, if any subspecies is protected by the laws of this country or the country of origin to the subspecies...

  13. 50 CFR 14.53 - Detention and refusal of clearance.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... origin of the wildlife has not been established (in such cases, the burden is upon the owner, importer, exporter, consignor, or consignee to establish such identity by scientific name to the species level or, if any subspecies is protected by the laws of this country or the country of origin to the subspecies...

  14. 50 CFR 14.53 - Detention and refusal of clearance.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... origin of the wildlife has not been established (in such cases, the burden is upon the owner, importer, exporter, consignor, or consignee to establish such identity by scientific name to the species level or, if any subspecies is protected by the laws of this country or the country of origin to the subspecies...

  15. 75 FR 72794 - Wooden Bedroom Furniture From the People's Republic of China: Preliminary Results of Antidumping...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-26

    ... cases, and entertainment systems; (6) bedroom furniture made primarily of wicker, cane, osier, bamboo or...: Scope Ruling on a White Toy Box,'' dated July 6, 2009, the dimensional ranges used to identify the toy...: APY Cane International; Arkane International Corporation; Berbenwood Industries Inc.; Clear Export...

  16. 76 FR 18716 - Manoj Bhayana, Respondent; Final Decision and Order

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-05

    ... statements to a BIS Special Agent during the course of an investigation. Aggravating Factors As addressed... factors affecting his ability to comply with the export regulations. And, while the court is sympathetic... allegations in this case stem from an investigation by the Bureau of Industry and Security (``BIS'') of a sale...

  17. 19 CFR 18.3 - Transshipment; transfer by bonded cartmen.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... under Customs supervision to another single conveyance while en route to the port of destination or... exportation. (c) Merchandise covered by a TIR carnet may be transshipped in a case involving the unlading of... en route. In the event of transshipment, a TIR approved container or road vehicle shall be used if...

  18. 19 CFR 18.3 - Transshipment; transfer by bonded cartmen.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... under Customs supervision to another single conveyance while en route to the port of destination or... exportation. (c) Merchandise covered by a TIR carnet may be transshipped in a case involving the unlading of... en route. In the event of transshipment, a TIR approved container or road vehicle shall be used if...

  19. 19 CFR 18.3 - Transshipment; transfer by bonded cartmen.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... under Customs supervision to another single conveyance while en route to the port of destination or... exportation. (c) Merchandise covered by a TIR carnet may be transshipped in a case involving the unlading of... en route. In the event of transshipment, a TIR approved container or road vehicle shall be used if...

  20. 19 CFR 18.3 - Transshipment; transfer by bonded cartmen.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... under Customs supervision to another single conveyance while en route to the port of destination or... exportation. (c) Merchandise covered by a TIR carnet may be transshipped in a case involving the unlading of... en route. In the event of transshipment, a TIR approved container or road vehicle shall be used if...

  1. 19 CFR 18.3 - Transshipment; transfer by bonded cartmen.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... under Customs supervision to another single conveyance while en route to the port of destination or... exportation. (c) Merchandise covered by a TIR carnet may be transshipped in a case involving the unlading of... en route. In the event of transshipment, a TIR approved container or road vehicle shall be used if...

  2. PARADIGM: The Partnership for Advancing Interdisciplinary Global Modeling Annual Report - Year 2

    DTIC Science & Technology

    2004-02-01

    case (a) when bacteria are able to regenerate ammonium based upon the composition of the dissolved organic pool. The export is also slightly larger...for diazotrophs and detritus. The addition of diazotrophs and detritus in the model follow the method of Fennel et al. [2002]. Time series of model

  3. 78 FR 2363 - Certain Cased Pencils From the People's Republic of China: Preliminary Results of Antidumping...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-11

    ... the People's Republic of China: Preliminary Results of Antidumping Duty Administrative Review and... Republic of China (``PRC''). The period of review (``POR'') is December 1, 2010, through November 30, 2011. The review covers one exporter of subject merchandise, Beijing Fila Dixon Stationery Company, Ltd. a...

  4. SPATIAL PATTERN OF WATER POLLUTION RISK IN MARYLAND, USA

    EPA Science Inventory

    Numerous field studies show that nitrogen (and phosphorous)export coefficients are significantly different acroos forest, agriculture, and urban land-cover types. We treated these export coefficients as a distribution, and used simulations to estimate the risk of increased nitro...

  5. 27 CFR 28.220a - Responsibility for return of wine withdrawn for export with benefit of drawback.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... of wine withdrawn for export with benefit of drawback. 28.220a Section 28.220a Alcohol, Tobacco... EXPORTATION OF ALCOHOL Exportation of Wine With Benefit of Drawback § 28.220a Responsibility for return of wine withdrawn for export with benefit of drawback. The exporter shall be responsible for arranging the...

  6. 75 FR 52453 - Entry Requirements for Certain Softwood Lumber Products Exported From Any Country Into the United...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-26

    ...)(3)(iii)(B)(3), which states that ``the exporter has paid, or committed to pay, all export charges..., to his best knowledge and belief, that the exporter has paid or committed to pay ``all export charges... discrepancies between the export permit date and the entry summary data. The commenter suggests using the...

  7. Aiding and Abetting Cancer: mRNA export and the nuclear pore

    PubMed Central

    Culjkovic-Kraljacic, Biljana; Borden, Katherine L.B

    2013-01-01

    mRNA export is a critical step in gene expression. Export of transcripts can be modulated in response to cellular signaling or stress. Consistently, mRNA export is dysregulated in primary human specimens derived from many different forms of cancer. Aberrant expression of export factors can alter export of specific transcripts encoding proteins involved in proliferation, survival and oncogenesis. These specific factors, which are not used for bulk mRNA export, are obvious therapeutic targets. Indeed, given the emerging role of mRNA export in cancer, it is not surprising that efforts to target different aspects of this pathway have reached the clinical trial stage. Thus, like transcription and translation, mRNA export may also play a critical role in cancer genesis and maintenance. PMID:23582887

  8. US Supreme Court set to hear oral arguments in Montana coal tax case

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Not Available

    1981-04-01

    Montana defends it 30% coal severance tax as proper compensation for exporting an exhaustible resource, but 11 utilities and four coal companies are suing on constitutional grounds. The suit charges that the tax does not balance costs and benefits and that it represents an effort to export tax burdens. Montana contends that the tax passed in 1975 recognizes the state's long-term needs by requiring that 50% of the revenue be placed in a permanent trust fund for future social and environmental adjustments and questions whether the courts can put a monetary value on these impacts. The plaintiffs see the trustmore » fund as an admission that the tax is excessive and the state's failure to comply with national energy policy. (DCK)« less

  9. Prediction in complex systems: The case of the international trade network

    NASA Astrophysics Data System (ADS)

    Vidmer, Alexandre; Zeng, An; Medo, Matúš; Zhang, Yi-Cheng

    2015-10-01

    Predicting the future evolution of complex systems is one of the main challenges in complexity science. Based on a current snapshot of a network, link prediction algorithms aim to predict its future evolution. We apply here link prediction algorithms to data on the international trade between countries. This data can be represented as a complex network where links connect countries with the products that they export. Link prediction techniques based on heat and mass diffusion processes are employed to obtain predictions for products exported in the future. These baseline predictions are improved using a recent metric of country fitness and product similarity. The overall best results are achieved with a newly developed metric of product similarity which takes advantage of causality in the network evolution.

  10. Nuclear export of ubiquitinated proteins via the UBIN-POST system

    PubMed Central

    Sugihara, Munechika; Morito, Daisuke; Iemura, Shun-ichiro; Natsume, Tohru; Nagata, Kazuhiro

    2018-01-01

    Although mechanisms for protein homeostasis in the cytosol have been studied extensively, those in the nucleus remain largely unknown. Here, we identified that a protein complex mediates export of polyubiquitinated proteins from the nucleus to the cytosol. UBIN, a ubiquitin-associated (UBA) domain-containing protein, shuttled between the nucleus and the cytosol in a CRM1-dependent manner, despite the lack of intrinsic nuclear export signal (NES). Instead, the UBIN binding protein polyubiquitinated substrate transporter (POST) harboring an NES shuttled UBIN through nuclear pores. UBIN bound to polyubiquitin chain through its UBA domain, and the UBIN-POST complex exported them from the nucleus to the cytosol. Ubiquitinated proteins accumulated in the cytosol in response to proteasome inhibition, whereas cotreatment with CRM1 inhibitor led to their accumulation in the nucleus. Our results suggest that ubiquitinated proteins are exported from the nucleus to the cytosol in the UBIN-POST complex-dependent manner for the maintenance of nuclear protein homeostasis. PMID:29666234

  11. Nuclear export of ubiquitinated proteins via the UBIN-POST system.

    PubMed

    Hirayama, Shoshiro; Sugihara, Munechika; Morito, Daisuke; Iemura, Shun-Ichiro; Natsume, Tohru; Murata, Shigeo; Nagata, Kazuhiro

    2018-05-01

    Although mechanisms for protein homeostasis in the cytosol have been studied extensively, those in the nucleus remain largely unknown. Here, we identified that a protein complex mediates export of polyubiquitinated proteins from the nucleus to the cytosol. UBIN, a ubiquitin-associated (UBA) domain-containing protein, shuttled between the nucleus and the cytosol in a CRM1-dependent manner, despite the lack of intrinsic nuclear export signal (NES). Instead, the UBIN binding protein polyubiquitinated substrate transporter (POST) harboring an NES shuttled UBIN through nuclear pores. UBIN bound to polyubiquitin chain through its UBA domain, and the UBIN-POST complex exported them from the nucleus to the cytosol. Ubiquitinated proteins accumulated in the cytosol in response to proteasome inhibition, whereas cotreatment with CRM1 inhibitor led to their accumulation in the nucleus. Our results suggest that ubiquitinated proteins are exported from the nucleus to the cytosol in the UBIN-POST complex-dependent manner for the maintenance of nuclear protein homeostasis. Copyright © 2018 the Author(s). Published by PNAS.

  12. The increasing impact of food production on nutrient export by rivers to the Bay of Bengal 1970-2050.

    PubMed

    Sattar, Abdus; Kroeze, Carolien; Strokal, Maryna

    2014-03-15

    The objective of this study is to assess the impact of food production on river export of nutrients to the coastal waters of the Bay of Bengal in the past (1970 and 2000) and the future (2030 and 2050), and the associated potential for coastal eutrophication. We model nutrient export from land to sea, using the Global NEWS (Nutrient Export from WaterSheds) approach. We calculate increases in river export of N and P over time. Agricultural sources account for about 70-80% of the N and P in rivers. The coastal eutrophication potential is high in the Bay. In 2000, nutrient discharge from about 85% of the basin area of the Bay drains into coastal seas contributes to the risk of coastal eutrophication. By 2050, this may be 96%. We also present an alternative scenario in which N and P inputs to the Bay are 20-35% lower than in the baseline. Copyright © 2014 Elsevier Ltd. All rights reserved.

  13. A novel mitochondrial carrier protein Mme1 acts as a yeast mitochondrial magnesium exporter.

    PubMed

    Cui, Yixian; Zhao, Shanke; Wang, Juan; Wang, Xudong; Gao, Bingquan; Fan, Qiangwang; Sun, Fei; Zhou, Bing

    2015-03-01

    The homeostasis of magnesium (Mg2+), an abundant divalent cation indispensable for many biological processes including mitochondrial functions, is underexplored. Previously, two mitochondrial Mg2+ importers, Mrs2 and Lpe10, were characterized for mitochondrial Mg2+ uptake. We now show that mitochondrial Mg2+ homeostasis is accurately controlled through the combined effects of previously known importers and a novel exporter, Mme1 (mitochondrial magnesium exporter 1). Mme1 belongs to the mitochondrial carrier family and was isolated for its mutation that is able to suppress the mrs2Δ respiration defect. Deletion of MME1 significantly increased steady-state mitochondrial Mg2+ concentration, while overexpression decreased it. Measurements of Mg2+ exit from proteoliposomes reconstituted with purified Mme1 provided definite evidence for Mme1 as an Mg2+ exporter. Our studies identified, for the first time, a mitochondrial Mg2+ exporter that works together with mitochondrial importers to ensure the precise control of mitochondrial Mg2+ homeostasis. Copyright © 2015 Elsevier B.V. All rights reserved.

  14. 77 FR 37871 - Export Trade Certificate of Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-25

    ... DEPARTMENT OF COMMERCE International Trade Administration [Application 12-00005] Export Trade Certificate of Review ACTION: Notice of Application for an Export Trade Certificate of Review from Colombia Rice Export Quota, Inc. SUMMARY: The Export Trading Company Affairs (``ETCA'') unit, Office of...

  15. 78 FR 85 - In the Matter of: Emenike Charles Nwankwoala Currently Incarcerated at: Inmate Number 50756-037...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-02

    ... willfully exporting, causing to be exported, and attempting to export from the United States to Nigeria..., causing to exported, and attempting to export from the United States to Nigeria shotguns without having...

  16. A Study of Comparative Advantage and Intra-Industry Trade in the Pharmaceutical Industry of Iran.

    PubMed

    Yusefzadeh, Hassan; Rezapour, Aziz; Lotfi, Farhad; Ebadifard Azar, Farbod; Nabilo, Bahram; Abolghasem Gorji, Hassan; Hadian, Mohammad; Shahidisadeghi, Niusha; Karami, Atiyeh

    2015-04-23

    Drug costs in Iran accounts for about 30% of the total health care expenditure. Moreover, pharmaceutical business lies among the world's greatest businesses. The aim of this study was to analyze Iran's comparative advantage and intra-industry trade in pharmaceuticals so that suitable policies can be developed and implemented in order to boost Iran's trade in this field. To identify Iran's comparative advantage in pharmaceuticals, trade specialization, export propensity, import penetration and Balassa and Vollrath indexes were calculated and the results were compared with other pharmaceutical exporting countries. The extent and growth of Iran's intra-industry trade in pharmaceuticals were measured and evaluated using the Grubel-Lloyd and Menon-Dixon indexes. The required data was obtained from Iran's Customs Administration, Iran's pharmaceutical Statistics, World Bank and International Trade Center. The results showed that among pharmaceutical exporting countries, Iran has a high level of comparative disadvantage in pharmaceutical products because it holds a small share in world's total pharmaceutical exports. Also, the low extent of bilateral intra-industry trade between Iran and its trading partners in pharmaceuticals shows the trading model of Iran's pharmaceutical industry is mostly inter-industry trade rather than intra-industry trade. In addition, the growth of Iran's intra-industry trade in pharmaceuticals is due to its shares of imports from pharmaceutical exporting countries to Iran and exports from Iran to its neighboring countries. The results of the analysis can play a valuable role in helping pharmaceutical companies and policy makers to boost pharmaceutical trade.

  17. SR proteins SRp20 and 9G8 contribute to efficient export of herpes simplex virus 1 mRNAs

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Escudero-Paunetto, Laurimar; Li Ling; Hernandez, Felicia P.

    2010-06-05

    Herpes simplex virus 1 (HSV-1) mRNAs are exported to the cytoplasm through the export receptor TAP/NFX1. HSV-1 multifunctional protein ICP27 interacts with TAP/NXF1, binds viral RNAs, and is required for efficient viral RNA export. In ICP27 mutant infections, viral RNA export is reduced but not ablated, indicating that other export adaptors can aid in viral RNA export. Export adaptor protein Aly/REF is recruited to viral replication compartments, however, Aly/REF knockdown has little effect on viral RNA export. SR proteins SRp20 and 9G8 interact with TAP/NXF1 and mediate export of some cellular RNAs. We report that siRNA knockdown of SRp20 ormore » 9G8 resulted in about a 10 fold decrease in virus yields and in nuclear accumulation of poly(A+) RNA. In infected cells depleted of SRp20, newly transcribed Bromouridine-labeled RNA also accumulated in the nucleus. We conclude that SRp20 and 9G8 contribute to HSV-1 RNA export.« less

  18. 40 CFR 168.85 - Other export requirements.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Other export requirements. 168.85... STATEMENTS OF ENFORCEMENT POLICIES AND INTERPRETATIONS Export Policy and Procedures for Exporting Unregistered Pesticides § 168.85 Other export requirements. This section describes other requirements found in...

  19. 7 CFR 51.2840 - Export packing requirements.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 2 2010-01-01 2010-01-01 false Export packing requirements. 51.2840 Section 51.2840 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards...) Export Packing Requirements § 51.2840 Export packing requirements. Onions specified as meeting Export...

  20. Are transnational tobacco companies' market access strategies linked to economic development models? A case study of South Korea.

    PubMed

    Lee, Sungkyu; Holden, Chris; Lee, Kelley

    2013-01-01

    Transnational tobacco companies (TTCs) have used varied strategies to access previously closed markets. Using TTCs' efforts to enter the South Korean market from the late 1980s as a case study, this article asks whether there are common patterns in these strategies that relate to the broader economic development models adopted by targeted countries. An analytical review of the existing literature on TTCs' efforts to access emerging markets was conducted to develop hypotheses relating TTCs' strategies to countries' economic development models. A case study of Korea was then undertaken based on analysis of internal tobacco industry documents. Findings were consistent with the hypothesis that TTCs' strategies in Korea were linked to Korea's export-oriented economic development model and its hostile attitude towards foreign investment. A fuller understanding of TTCs' strategies for expansion globally can be derived by locating them within the economic development models of specific countries or regions. Of foremost importance is the need for governments to carefully balance economic and public health policies when considering liberalisation.

  1. Are transnational tobacco companies’ market access strategies linked to economic development models? A case study of South Korea

    PubMed Central

    Lee, Sungkyu; Holden, Chris; Lee, Kelley

    2013-01-01

    Transnational tobacco companies (TTCs) have used varied strategies to access previously closed markets. Using TTCs’ efforts to enter the South Korean market from the late 1980s as a case study, this article asks whether there are common patterns in these strategies that relate to the broader economic development models adopted by targeted countries. An analytical review of the existing literature on TTCs’ efforts to access emerging markets was conducted to develop hypotheses relating TTCs’ strategies to countries’ economic development models. A case study of Korea was then undertaken based on analysis of internal tobacco industry documents. Findings were consistent with the hypothesis that TTCs’ strategies in Korea were linked to Korea’s export-oriented economic development model and its hostile attitude toward foreign investment. A fuller understanding of TTCs’ strategies for expansion globally can be derived by locating them within the economic development models of specific countries or regions. Of foremost importance is the need for governments to carefully balance economic and public health policies when considering liberalisation. PMID:23327486

  2. 75 FR 52929 - President's Export Council: Meeting of the President's Export Council

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-30

    ... DEPARTMENT OF COMMERCE International Trade Administration President's Export Council: Meeting of the President's Export Council AGENCY: International Trade Administration, U.S. Department of Commerce...: The President's Export Council will convene its next meeting via live webcast on the Internet at http...

  3. 50 CFR 300.189 - Prohibitions.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... under § 300.182. (b) Import as an entry for consumption, purchase, receive for export, export, or re... are imported, entered for consumption, exported, or re-exported. (g) Fail to comply with the documentation requirements as specified in § 300.186, for the importation, entry for consumption, exportation...

  4. 50 CFR 300.189 - Prohibitions.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... under § 300.182. (b) Import as an entry for consumption, purchase, receive for export, export, or re... are imported, entered for consumption, exported, or re-exported. (g) Fail to comply with the documentation requirements as specified in § 300.186, for the importation, entry for consumption, exportation...

  5. 50 CFR 300.189 - Prohibitions.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... under § 300.182. (b) Import as an entry for consumption, purchase, receive for export, export, or re... are imported, entered for consumption, exported, or re-exported. (g) Fail to comply with the documentation requirements as specified in § 300.186, for the importation, entry for consumption, exportation...

  6. 78 FR 58995 - Order Denying Export Privileges

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-25

    ... DEPARTMENT OF COMMERCE Bureau of Industry and Security Order Denying Export Privileges In the...''). Specifically, Kazerani was convicted of knowingly and willfully exporting and causing the exportation of laptop..., a $10,000 criminal fine and an assessment of $100. Section 766.25 of the Export Administration...

  7. 7 CFR 1493.80 - Evidence of export.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Evidence of export. 1493.80 Section 1493.80... OF AGRICULTURE LOANS, PURCHASES, AND OTHER OPERATIONS CCC EXPORT CREDIT GUARANTEE PROGRAMS CCC Export Credit Guarantee Program (GSM-102) and CCC Intermediate Export Credit Guarantee Program (GSM-103...

  8. 19 CFR 19.38 - Supervision of exportation.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 19 Customs Duties 1 2014-04-01 2014-04-01 false Supervision of exportation. 19.38 Section 19.38... Supervision of exportation. (a) Sales ticket withdrawals. Conditionally duty-free merchandise withdrawn under the sales ticket procedure for exportation shall be exported only under Customs supervision as...

  9. 19 CFR 19.38 - Supervision of exportation.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 19 Customs Duties 1 2012-04-01 2012-04-01 false Supervision of exportation. 19.38 Section 19.38... Supervision of exportation. (a) Sales ticket withdrawals. Conditionally duty-free merchandise withdrawn under the sales ticket procedure for exportation shall be exported only under Customs supervision as...

  10. 19 CFR 19.38 - Supervision of exportation.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 19 Customs Duties 1 2011-04-01 2011-04-01 false Supervision of exportation. 19.38 Section 19.38... Supervision of exportation. (a) Sales ticket withdrawals. Conditionally duty-free merchandise withdrawn under the sales ticket procedure for exportation shall be exported only under Customs supervision as...

  11. 19 CFR 19.38 - Supervision of exportation.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Supervision of exportation. 19.38 Section 19.38... Supervision of exportation. (a) Sales ticket withdrawals. Conditionally duty-free merchandise withdrawn under the sales ticket procedure for exportation shall be exported only under Customs supervision as...

  12. 19 CFR 19.38 - Supervision of exportation.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 19 Customs Duties 1 2013-04-01 2013-04-01 false Supervision of exportation. 19.38 Section 19.38... Supervision of exportation. (a) Sales ticket withdrawals. Conditionally duty-free merchandise withdrawn under the sales ticket procedure for exportation shall be exported only under Customs supervision as...

  13. Survey of resource opportunities and critical evaluation of economic requirements

    NASA Technical Reports Server (NTRS)

    Clark, Benton C.

    1991-01-01

    A series of mission analyses were performed to evaluate human mission to Mars and the moon with and without the aid of planetary resource utilization. The types of trade studies that are considered include the use of resources to manufacture propellant, food, habitat atmospheric gases, and lander habitat structure. Also, the potential for export of resources from the moon, Mars, Phobos, Deimos, and selected asteroids is also examined. In all cases, mass leveraging is evaluated. For certain cases, economic factors are evaluated as well. It is concluded that some uses are highly leveraging on the mission, whereas others have lesser impact and, therefore, should be afforded lesser priority in resource utilization studies. This survey is made with a consistent set of scaling laws for spacecraft propulsion and habitation systems and subsystems, and therefore, provides a rational basis for comparing different resource locations and use strategies.

  14. Nuclear Export and Expression of Human T-Cell Leukemia Virus Type 1 tax/rex mRNA Are RxRE/Rex Dependent

    PubMed Central

    Bai, X. T.; Sinha-Datta, U.; Ko, N. L.; Bellon, M.

    2012-01-01

    Human T-cell leukemia virus type 1 (HTLV-1) is a complex retrovirus associated with the lymphoproliferative disease adult T-cell leukemia/lymphoma (ATL) and the neurodegenerative disorder tropical spastic paraparesis/HTLV-1-associated myelopathy (TSP/HAM). Replication of HTLV-1 is under the control of two major trans-acting proteins, Tax and Rex. Previous studies suggested that Tax activates transcription from the viral long terminal repeat (LTR) through recruitment of cellular CREB and transcriptional coactivators. Other studies reported that Rex acts posttranscriptionally and allows the cytoplasmic export of unspliced or incompletely spliced viral mRNAs carrying gag/pol and env only. As opposed to HIV's Rev-responsive element (RRE), the Rex-responsive element (RxRE) is present in all viral mRNAs in HTLV-1. However, based on indirect observations, it is believed that nuclear export and expression of the doubly spliced tax/rex RNA are Rex independent. In this study, we demonstrate that Rex does stimulate Tax expression, through nuclear-cytoplasmic export of the tax/rex RNA, even though a Rex-independent basal export mechanism exists. This effect was dependent upon the RxRE element and the RNA-binding activity of Rex. In addition, Rex-mediated export of tax/rex RNA was CRM1 dependent and inhibited by leptomycin B treatment. RNA immunoprecipitation (RNA-IP) experiments confirmed Rex binding to the tax/rex RNA in both transfected cells with HTLV-1 molecular clones and HTLV-1-infected T cells. Since both Rex and p30 interact with the tax/rex RNA and with one another, this may offer a temporal and dynamic regulation of HTLV-1 replication. Our results shed light on HTLV-1 replication and reveal a more complex regulatory network than previously anticipated. PMID:22318152

  15. 40 CFR 799.19 - Chemical imports and exports.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 32 2011-07-01 2011-07-01 false Chemical imports and exports. 799.19... CONTROL ACT (CONTINUED) IDENTIFICATION OF SPECIFIC CHEMICAL SUBSTANCE AND MIXTURE TESTING REQUIREMENTS General Provisions § 799.19 Chemical imports and exports. Persons who export or who intend to export...

  16. 75 FR 11118 - Export Trade Certificate of Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-10

    ... DEPARTMENT OF COMMERCE International Trade Administration [Application No. 99-4A005] Export Trade Certificate of Review ACTION: Notice of Application ( 99-4A005) to Amend the Export Trade Certificate of Review Issued to California Almond Export Association, LLC, Application no. 99-00005. SUMMARY: The Export...

  17. 14 CFR 21.325 - Export airworthiness approvals.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Export airworthiness approvals. 21.325... AIRCRAFT CERTIFICATION PROCEDURES FOR PRODUCTS AND PARTS Export Airworthiness Approvals § 21.325 Export airworthiness approvals. (a) Kinds of approvals. (1) Export airworthiness approval of Class I products is issued...

  18. 7 CFR 1493.470 - Evidence of export.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Evidence of export. 1493.470 Section 1493.470... OF AGRICULTURE LOANS, PURCHASES, AND OTHER OPERATIONS CCC EXPORT CREDIT GUARANTEE PROGRAMS CCC Supplier Credit Guarantee Program Operations § 1493.470 Evidence of export. (a) Report of export. The...

  19. 75 FR 51980 - Export Trade Certificate of Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-24

    ... DEPARTMENT OF COMMERCE International Trade Administration [Application No. 84-21A12] Export Trade Certificate of Review ACTION: Notice of Issuance of an amended Export Trade Certificate of Review to Northwest... amended Export Trade Certificate of Review to Northwest Fruit Exporters on August 18, 2010. The...

  20. 27 CFR 28.30 - Export status.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Export status. 28.30... Export status. (a) Distilled spirits and wines manufactured, produced, bottled in bottles packed in... such purposes are considered to be exported. Export status is not acquired until application on Form...

  1. 40 CFR 799.19 - Chemical imports and exports.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 31 2010-07-01 2010-07-01 true Chemical imports and exports. 799.19 Section 799.19 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES... General Provisions § 799.19 Chemical imports and exports. Persons who export or who intend to export...

  2. 40 CFR 799.19 - Chemical imports and exports.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 33 2012-07-01 2012-07-01 false Chemical imports and exports. 799.19... CONTROL ACT (CONTINUED) IDENTIFICATION OF SPECIFIC CHEMICAL SUBSTANCE AND MIXTURE TESTING REQUIREMENTS General Provisions § 799.19 Chemical imports and exports. Persons who export or who intend to export...

  3. 40 CFR 799.19 - Chemical imports and exports.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 33 2013-07-01 2013-07-01 false Chemical imports and exports. 799.19... CONTROL ACT (CONTINUED) IDENTIFICATION OF SPECIFIC CHEMICAL SUBSTANCE AND MIXTURE TESTING REQUIREMENTS General Provisions § 799.19 Chemical imports and exports. Persons who export or who intend to export...

  4. 40 CFR 799.19 - Chemical imports and exports.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 32 2014-07-01 2014-07-01 false Chemical imports and exports. 799.19... CONTROL ACT (CONTINUED) IDENTIFICATION OF SPECIFIC CHEMICAL SUBSTANCE AND MIXTURE TESTING REQUIREMENTS General Provisions § 799.19 Chemical imports and exports. Persons who export or who intend to export...

  5. 75 FR 52505 - Fiscal Year 2011 Veterinary Import/Export Services, Veterinary Diagnostic Services, and Export...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-26

    ...] Fiscal Year 2011 Veterinary Import/Export Services, Veterinary Diagnostic Services, and Export... certain veterinary diagnostic services; and for export certification of plants and plant products. The..., through September 30, 2011). FOR FURTHER INFORMATION CONTACT: For information on Veterinary Diagnostic...

  6. Globalization Theory: Lessons from the Exportation of McDonaldization and the New Means of Consumption

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Ritzer, George; Malone, Elizabeth L.; Ritzer, George

    2001-07-30

    McDonaldization and the exportation of the new means of consumption tend to support the view that in at least some sectors the world is growing more homogeneous than heterogeneous. Against those globalization theorists who tend to focus on the importance of the local and therefore on heterogeneity, the study of McDonaldization and the new means of consumption emphasizes transnational issues and uniformity throughout the world. Fast-food restaurants do adapt to local markets, but the basic procedures of operation and marketing remain the same across a wide range of international settings. This is true even of indigenous versions. The uniformity ismore » exported by transnational corporations, with nation-states less and less able to control or restrict such exports.« less

  7. Globalization Theory: Lessons from the Exportation of McDonaldization and the New Means of Consumption

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Ritzer, George; Malone, Elizabeth L.

    2000-07-31

    McDonaldization and the exportation of the new means of consumption tend to support the view that in at least some sectors the world is growing more homogeneous than heterogeneous. Against those globalization theorists who tend to focus on the importance of the local and therefore on heterogeneity, the study of McDonaldization and the new means of consumption emphasizes transnational issues and uniformity throughout the world. Fast-food restaurants do adapt to local markets, but the basic procedures of operation and marketing remain the same across a wide range of international settings. This is true even of indigenous versions. The uniformity ismore » exported by transnational corporations, with nation-states less and less able to control or restrict such exports.« less

  8. International Trade in Environmental Protection Equipment: An Assessment of Existing Data (1993)

    EPA Pesticide Factsheets

    Study estimates total U.S. imports, exports, and trade balances for environmental protection (EP) equipment between 1980-1991. While the United States is a major exporter of EP equipment, trade in EP equipment constitutes a small percent of total US trade.

  9. Hydrologic and biogeochemical controls on phosphorus export from western Lake Erie tributaries

    USDA-ARS?s Scientific Manuscript database

    Understanding the processes controlling phosphorus (P) export from agricultural watersheds is essential for predicting and mitigating adverse environmental impacts. In this study, discharge, dissolved reactive phosphorus load, and total phosphorus load time series data (1975-2014) from two Lake Erie...

  10. Organic forms dominate hydrologic nitrogen export from a lowland tropical watershed.

    PubMed

    Taylor, Philip G; Wieder, William R; Weintraub, Samantha; Cohen, Sagy; Cleveland, Cory C; Townsend, Alan R

    2015-05-01

    Observations of high dissolved inorganic nitrogen (DIN) concentrations in stream water have reinforced the notion that primary tropical rain forests cycle nitrogen (N) in relative excess compared to phosphorus. Here we test this notion by evaluating hydrologic N export from a small watershed on the Osa Peninsula, Costa Rica, where prior research has shown multiple indicators of conservative N cycling throughout the ecosystem. We repeatedly measured a host of factors known to influence N export for one year, including stream water chemistry and upslope litterfall, soil N availability and net N processing rates, and soil solution chemistry at the surface, 15- and 50-cm depths. Contrary to prevailing assumptions about the lowland N cycle, we find that dissolved organic nitrogen (DON) averaged 85% of dissolved N export for 48 of 52 consecutive weeks. For most of the year stream water nitrate (NO3-) export was very low, which reflected minimal net N processing and DIN leaching from upslope soils. Yet, for one month in the dry season, NO3- was the major component of N export due to a combination of low flows and upslope nitrification that concentrated NO3- in stream water. Particulate organic N (PON) export was much larger than dissolved forms at 14.6 kg N x ha(-1) x yr(-1), driven by soil erosion during storms. At this rate, PON export was slightly greater than estimated inputs from free-living N fixation and atmospheric N deposition, which suggests that erosion-driven PON export could constrain ecosystem level N stocks over longer timescales. This phenomenon is complimentary to the "DON leak" hypothesis, which postulates that the long-term accumulation of ecosystem N in unpolluted ecosystems is constrained by the export of organic N independently of biological N demand. Using an established global sediment generation model, we illustrate that PON erosion may be an important vector for N loss in tropical landscapes that are geomorphically active. This study supports an emerging view that landscape geomorphology influences nutrient biogeochemistry and limitation, though more research is needed to understand the mechanisms and spatial significance of erosional N loss from terrestrial ecosystems.

  11. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Boyd, P.W.; Gall, M.P.; Silver, M.W.

    A central question addressed by the VERTIGO (VERtical Transport In the Global Ocean) study was 'What controls the efficiency of particle export between the surface and subsurface ocean'? Here, we present data from sites at ALOHA (N Central Pacific Gyre) and K2 (NW subarctic Pacific) on phytoplankton processes, and relate them via a simple planktonic foodweb model, to subsurface particle export (150-500 m). Three key factors enable quantification of the surface-subsurface coupling: a sampling design to overcome the temporal lag and spatial displacement between surface and subsurface processes; data on the size-partitioning of Net Primary Production (NPP) and subsequent transformationsmore » prior to export; estimates of the ratio of algal- to faecal-mediated vertical export flux. At ALOHA, phytoplankton were characterized by low stocks, NPP, F{sub v}/F{sub m} (N-limited), and were dominated by picoplankton. The HNLC waters at K2 were characterized by both two-fold changes in NPP and floristic shifts (high to low proportion of diatoms) between deployment 1 and 2. Prediction of export exiting the euphotic zone was based on size-partitioning of NPP, a copepod-dominated foodweb and a ratio of 0.2 (ALOHA) and 0.1 (K2) for algal:faecal particle flux. Predicted export was 20-22 mg POC m{sup -2} d{sup -1} at ALOHA (i.e. 10-11% NPP (0-125 m); 1.1-1.2 x export flux at 150 m (E{sub 150}). At K2, export was 111 mg C m{sup -2} d{sup -1} (21% NPP (0-50 m); 1.8 x E{sub 150}) and 33 mg POC m{sup -2} d{sup -1} (11% NPP, 0-55 m); 1.4 x E{sub 150}) for deployments 1 and 2, respectively. This decrease in predicted export at K2 matches the observed trend for E{sub 150}. Also, the low attenuation of export flux from 60 to 150 m is consistent with that between 150 to 500 m. This strong surface-subsurface coupling suggests that phytoplankton productivity and floristics play a key role at K2 in setting export flux, and moreover that pelagic particle transformations by grazers strongly influence to what extent sinking particles are further broken down in the underlying waters of the Twilight Zone.« less

  12. Contribution of atmospheric nitrogen deposition to diffuse pollution in a typical hilly red soil catchment in southern China.

    PubMed

    Shen, Jianlin; Liu, Jieyun; Li, Yong; Li, Yuyuan; Wang, Yi; Liu, Xuejun; Wu, Jinshui

    2014-09-01

    Atmospheric nitrogen (N) deposition is currently high and meanwhile diffuse N pollution is also serious in China. The correlation between N deposition and riverine N export and the contribution of N deposition to riverine N export were investigated in a typical hilly red soil catchment in southern China over a two-year period. N deposition was as high as 26.1 to 55.8kgN/(ha·yr) across different land uses in the studied catchment, while the riverine N exports ranged from 7.2 to 9.6kgN/(ha·yr) in the forest sub-catchment and 27.4 to 30.3kgN/(ha·yr) in the agricultural sub-catchment. The correlations between both wet N deposition and riverine N export and precipitation were highly positive, and so were the correlations between NH4(+)-N or NO3(-)-N wet deposition and riverine NH4(+)-N or NO3(-)-N exports except for NH4(+)-N in the agricultural sub-catchment, indicating that N deposition contributed to riverine N export. The monthly export coefficients of atmospheric deposited N from land to river in the forest sub-catchment (with a mean of 14%) presented a significant positive correlation with precipitation, while the monthly contributions of atmospheric deposition to riverine N export (with a mean of 18.7% in the agricultural sub-catchment and a mean of 21.0% in the whole catchment) were significantly and negatively correlated with precipitation. The relatively high contribution of N deposition to diffuse N pollution in the catchment suggests that efforts should be done to control anthropogenic reactive N emissions to the atmosphere in hilly red soil regions in southern China. Copyright © 2014. Published by Elsevier B.V.

  13. Identification of Bicarbonate as a Trigger and Genes Involved with Extracellular DNA Export in Mycobacterial Biofilms

    PubMed Central

    Rose, Sasha J.

    2016-01-01

    ABSTRACT Extracellular DNA (eDNA) is an integral biofilm matrix component of numerous pathogens, including nontuberculous mycobacteria (NTM). Cell lysis is the source of eDNA in certain bacteria, but the source of eDNA remains unidentified for NTM, as well as for other eDNA-containing bacterial species. In this study, conditions affecting eDNA export were examined, and genes involved with the eDNA export mechanism were identified. After a method for monitoring eDNA in real time in undisturbed biofilms was established, different conditions affecting eDNA were investigated. Bicarbonate positively influenced eDNA export in a pH-independent manner in Mycobacterium avium, M. abscessus, and M. chelonae. The surface-exposed proteome of M. avium in eDNA-containing biofilms revealed abundant carbonic anhydrases. Chemical inhibition of carbonic anhydrases with ethoxzolamide significantly reduced eDNA export. An unbiased transposon mutant library screen for eDNA export in M. avium identified many severely eDNA-attenuated mutants, including one not expressing a unique FtsK/SpoIIIE-like DNA-transporting pore, two with inactivation of carbonic anhydrases, and nine with inactivation of genes belonging to a unique genomic region, as well as numerous mutants involved in metabolism and energy production. Complementation of nine mutants that included the FtsK/SpoIIIE and carbonic anhydrase significantly restored eDNA export. Interestingly, several attenuated eDNA mutants have mutations in genes encoding proteins that were found with the surface proteomics, and many more mutations are localized in operons potentially encoding surface proteins. Collectively, our data strengthen the evidence of eDNA export being an active mechanism that is activated by the bacterium responding to bicarbonate. PMID:27923918

  14. Carbohydrate production, balance and translocation in leaves, shoots and fruits of Montmorency sour cherry

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kappes, E.M.

    1986-01-01

    Carbohydrate production, export and use were studied for different organs of sour cherry (Prunus cerasus L. Montmorency). Gross carbohydrate (/sup 14/CO/sub 2/) export started between 27.2 and 77.6% of full leaf expansion. The 10th leaf developing started export later than the 7th leaf, suggesting that higher carbohydrate availability during leaf expansion delays export initiation. In support of this, gross export started earlier (44.4-52.4% full expansion) after source leaf removal, than in the control (77.6%). Translocation was primarily vertical (following orthostichies). Most leaves of fruiting shoots exported bidirectionally to the apex and fruits, only leaves closest to fruits exported exclusively tomore » fruits during rapid cell division (Stage I) and rapid cell expansion (Stage III). Net export, determined from carbohydrate balance models started at 17 and 51% expansion for the 7th and terminal leaf, and at 26.5% of shoot elongation. Cumulative carbohydrate production of the 7th and terminal leaves during the first 9 and 11 days after emergence, exceeded carbohydrate accumulated at final size, 464.2 and 148.9 mg. A fruit carbohydrate balance was developed to determine contributions by fruit photosynthesis and fruit respiration, and to identify periods of greatest carbohydrate import. Fruit photosynthesis during development was characterized under different environmental conditions. Gross photosynthesis and chlorophyll content per fruit increased to a maximum during stage II and decreased thereafter. Gross photosynthesis approached a maximum at 40/sub 0/C. Since dark respiration increased exponentially over the same temperature range, net photosynthesis reached a maximum at 18/sup 0/C. Photorespiration was not detected.« less

  15. Primary production export flux in Marguerite Bay (Antarctic Peninsula): Linking upper water-column production to sediment trap flux

    NASA Astrophysics Data System (ADS)

    Weston, Keith; Jickells, Timothy D.; Carson, Damien S.; Clarke, Andrew; Meredith, Michael P.; Brandon, Mark A.; Wallace, Margaret I.; Ussher, Simon J.; Hendry, Katharine R.

    2013-05-01

    A study was carried out to assess primary production and associated export flux in the coastal waters of the western Antarctic Peninsula at an oceanographic time-series site. New, i.e., exportable, primary production in the upper water-column was estimated in two ways; by nutrient deficit measurements, and by primary production rate measurements using separate 14C-labelled radioisotope and 15N-labelled stable isotope uptake incubations. The resulting average annual exportable primary production estimates at the time-series site from nutrient deficit and primary production rates were 13 and 16 mol C m-2, respectively. Regenerated primary production was measured using 15N-labelled ammonium and urea uptake, and was low throughout the sampling period. The exportable primary production measurements were compared with sediment trap flux measurements from 2 locations; the time-series site and at a site 40 km away in deeper water. Results showed ˜1% of the upper mixed layer exportable primary production was exported to traps at 200 m depth at the time-series site (total water column depth 520 m). The maximum particle flux rate to sediment traps at the deeper offshore site (total water column depth 820 m) was lower than the flux at the coastal time-series site. Flux of particulate organic carbon was similar throughout the spring-summer high flux period for both sites. Remineralisation of particulate organic matter predominantly occurred in the upper water-column (<200 m depth), with minimal remineralisation below 200 m, at both sites. This highly productive region on the Western Antarctic Peninsula is therefore best characterised as 'high recycling, low export'.

  16. Virtual industrial water usage and wastewater generation in the Middle East/North African region

    NASA Astrophysics Data System (ADS)

    Sakhel, S. R.; Geissen, S.-U.; Vogelpohl, A.

    2013-01-01

    This study deals with the quantification of volumes of water usage, wastewater generation, virtual water export, and wastewater generation from export for eight export relevant industries present in the Middle East/North Africa (MENA). It shows that about 3400 million m3 of water is used per annum while around 793 million m3 of wastewater is generated from products that are meant for domestic consumption and export. The difference between volumes of water usage and wastewater generation is due to water evaporation or injecting underground (oil wells pressure maintenance). The wastewater volume generated from production represents a population equivalent of 15.5 million in terms of wastewater quantity and 30.4 million in terms of BOD. About 409 million m3 of virtual water flows from MENA to EU27 (resulting from export of eight commodities) which is equivalent to 12.1% of the water usage of those industries and Libya is the largest virtual water exporter (about 87 million m3). Crude oil and refined petroleum products represent about 89% of the total virtual water flow, fertilizers represent around 10% and 1% remaining industries. EU27 poses the greatest indirect pressure on the Kuwaiti hydrological system where the virtual water export represents about 96% of the actual renewable water resources in this country. The Kuwaiti crude oil water use in relation to domestic water withdrawal is about 89% which is highest among MENA countries. Pollution of water bodies, in terms of BOD, due to production is very relevant for crude oil, slaughterhouses, refineries, olive oil, and tanneries while pollution due to export to EU27 is most relevant for crude oil industry and olive oil mills.

  17. 31 CFR 592.201 - Prohibited importation and exportation of any rough diamond; permitted importation or exportation...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... of any rough diamond; permitted importation or exportation of any rough diamond. 592.201 Section 592... FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY ROUGH DIAMONDS CONTROL REGULATIONS Prohibitions § 592.201 Prohibited importation and exportation of any rough diamond; permitted importation or exportation...

  18. 31 CFR 592.201 - Prohibited importation and exportation of any rough diamond; permitted importation or exportation...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... of any rough diamond; permitted importation or exportation of any rough diamond. 592.201 Section 592... FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY ROUGH DIAMONDS CONTROL REGULATIONS Prohibitions § 592.201 Prohibited importation and exportation of any rough diamond; permitted importation or exportation...

  19. 31 CFR 592.201 - Prohibited importation and exportation of any rough diamond; permitted importation or exportation...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... of any rough diamond; permitted importation or exportation of any rough diamond. 592.201 Section 592... FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY ROUGH DIAMONDS CONTROL REGULATIONS Prohibitions § 592.201 Prohibited importation and exportation of any rough diamond; permitted importation or exportation...

  20. 31 CFR 592.201 - Prohibited importation and exportation of any rough diamond; permitted importation or exportation...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... of any rough diamond; permitted importation or exportation of any rough diamond. 592.201 Section 592... FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY ROUGH DIAMONDS CONTROL REGULATIONS Prohibitions § 592.201 Prohibited importation and exportation of any rough diamond; permitted importation or exportation...

  1. 48 CFR 552.211-88 - Vehicle export preparation.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 4 2012-10-01 2012-10-01 false Vehicle export preparation... Vehicle export preparation. As prescribed in 511.204(b)(8), insert the following clause: Vehicle Export Preparation (JAN 2010) Vehicles shall be prepared for export on wheels, unboxed, unless otherwise specified in...

  2. 48 CFR 552.211-88 - Vehicle export preparation.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 4 2014-10-01 2014-10-01 false Vehicle export preparation... Vehicle export preparation. As prescribed in 511.204(b)(8), insert the following clause: Vehicle Export Preparation (JAN 2010) Vehicles shall be prepared for export on wheels, unboxed, unless otherwise specified in...

  3. 19 CFR 192.3 - Penalties.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ...) EXPORT CONTROL Exportation of Used Self-Propelled Vehicles, Vessels, and Aircraft § 192.3 Penalties. (a... importer or exporter who knowingly imports, exports or attempts to import or export: (1) Any stolen self-propelled vehicle, vessel, aircraft or part of a self-propelled vehicle, vessel or aircraft; or (2) Any self...

  4. 19 CFR 192.3 - Penalties.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ...) EXPORT CONTROL Exportation of Used Self-Propelled Vehicles, Vessels, and Aircraft § 192.3 Penalties. (a... importer or exporter who knowingly imports, exports or attempts to import or export: (1) Any stolen self-propelled vehicle, vessel, aircraft or part of a self-propelled vehicle, vessel or aircraft; or (2) Any self...

  5. 50 CFR 300.183 - Permit holder reporting and recordkeeping requirements.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... biweekly report of entries for consumption, exports and re-exports of fish and fish products regulated... products regulated under this subpart except shark fins were entered for consumption, exported, or re..., that is entered for consumption, exported, or re-exported. (3) A biweekly report is not required for...

  6. 50 CFR 300.183 - Permit holder reporting and recordkeeping requirements.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... biweekly report of entries for consumption, exports and re-exports of fish and fish products regulated... products regulated under this subpart except shark fins were entered for consumption, exported, or re..., that is entered for consumption, exported, or re-exported. (3) A biweekly report is not required for...

  7. 50 CFR 300.183 - Permit holder reporting and recordkeeping requirements.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... biweekly report of entries for consumption, exports and re-exports of fish and fish products regulated... products regulated under this subpart except shark fins were entered for consumption, exported, or re..., that is entered for consumption, exported, or re-exported. (3) A biweekly report is not required for...

  8. 76 FR 11756 - Action Affecting Export Privileges; Ali Amirnazmi; Order Denying Export Privileges

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-03

    ... DEPARTMENT OF COMMERCE Bureau of Industry and Security Action Affecting Export Privileges; Ali Amirnazmi; Order Denying Export Privileges In the Matter of: Ali Amirnazmi, Register 63302-066, FCI... release and forfeit $81,277.37. Section 766.25 of the Export Administration Regulations (``EAR'' or...

  9. 15 CFR 2012.3 - Export certificates.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 15 Commerce and Foreign Trade 3 2010-01-01 2010-01-01 false Export certificates. 2012.3 Section... STATES TRADE REPRESENTATIVE IMPLEMENTATION OF TARIFF-RATE QUOTAS FOR BEEF § 2012.3 Export certificates... export certificate is in effect with respect to the beef. (b) To be valid, an export certificate shall...

  10. 31 CFR 592.304 - Exporting authority.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Exporting authority. 592.304 Section... § 592.304 Exporting authority. (a) The term exporting authority means one or more entities designated by a Participant from whose territory a shipment of rough diamonds is being exported as having the...

  11. 78 FR 1837 - Export Trade Certificate of Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-09

    ... DEPARTMENT OF COMMERCE International Trade Administration [Application No. 84-23A12] Export Trade Certificate of Review ACTION: Notice of issuance of an Export Trade Certificate of Review to Northwest Fruit Exporters, Application No. 84-23A12. SUMMARY: The U.S. Department of Commerce issued an amended Export Trade...

  12. 76 FR 55010 - Export Trade Certificate of Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-06

    ... DEPARTMENT OF COMMERCE International Trade Administration [Application No. 84-22A12] Export Trade Certificate of Review ACTION: Notice of issuance of an Export Trade Certificate of Review to Northwest Fruit Exporters, Application no. 84-22A12. SUMMARY: The U.S. Department of Commerce issued an amended Export Trade...

  13. 50 CFR 222.205 - Import and export requirements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 50 Wildlife and Fisheries 7 2010-10-01 2010-10-01 false Import and export requirements. 222.205... Certificates of Exemption for Pre-Act Endangered Species Parts § 222.205 Import and export requirements. (a... intended for importation into or exportation from the United States, shall not be imported or exported...

  14. 40 CFR 89.909 - Export exemptions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 20 2010-07-01 2010-07-01 false Export exemptions. 89.909 Section 89....909 Export exemptions. (a) A new nonroad engine intended solely for export, and so labeled or tagged..., 1200 Pennsylvania Ave., NW., Washington, DC 20460. New nonroad engines exported to such countries must...

  15. 78 FR 53727 - Export Trade Certificate of Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-30

    ... DEPARTMENT OF COMMERCE International Trade Administration [Application No. 84-24A12] Export Trade Certificate of Review ACTION: Notice of Issuance of an Export Trade Certificate of Review to Northwest Fruit Exporters, Application No. 84-24A12. SUMMARY: The U.S. Department of Commerce issued an amended Export Trade...

  16. 40 CFR 92.909 - Export exemptions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 20 2010-07-01 2010-07-01 false Export exemptions. 92.909 Section 92....909 Export exemptions. (a) A new locomotive or locomotive engine intended solely for export, and so... from EPA standards. (c) It is a condition of any exemption for the purpose of export under paragraph (a...

  17. 9 CFR 91.3 - General export requirements.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false General export requirements. 91.3... HANDLING OF LIVESTOCK FOR EXPORTATION General Provisions § 91.3 General export requirements. (a) All... accompanied from the State of origin of the export movement to the port of embarkation by an origin health...

  18. 40 CFR 91.1009 - Export exemptions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 20 2010-07-01 2010-07-01 false Export exemptions. 91.1009 Section 91....1009 Export exemptions. (a) A new marine SI engine intended solely for export, and so labeled or tagged...., Washington, DC 20460. New marine SI engines exported to such countries must comply with EPA certification...

  19. 37 CFR 5.19 - Export of technical data.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2010-07-01 2010-07-01 false Export of technical data. 5..., DEPARTMENT OF COMMERCE GENERAL SECRECY OF CERTAIN INVENTIONS AND LICENSES TO EXPORT AND FILE APPLICATIONS IN FOREIGN COUNTRIES Licenses for Foreign Exporting and Filing § 5.19 Export of technical data. (a) Under...

  20. 7 CFR 1493.280 - Evidence of export report.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Evidence of export report. 1493.280 Section 1493.280... OF AGRICULTURE LOANS, PURCHASES, AND OTHER OPERATIONS CCC EXPORT CREDIT GUARANTEE PROGRAMS CCC Facility Guarantee Program (FGP) Operations § 1493.280 Evidence of export report. (a) Report of export. The...

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