Conducting Research on the International Space Station Using the EXPRESS Rack Facilities

NASA Technical Reports Server (NTRS)

Thompson, Sean W.; Lake, Robert E.

2014-01-01

EXPRESS Racks provide capability for payload access to ISS resources. The successful on-orbit operations and versatility of the EXPRESS Rack has facilitated the operations of many scientific areas, with the promise of continued payload support for years to come. EXPRESS Racks are currently deployed in the US Lab, Columbus and JEM. Process improvements and enhancements continue to improve the accommodations and make the integration and operations process more efficient. Payload Integration Managers serve as the primary interface between the ISS Program and EXPRESS Payload Developers. EXPRESS Project coordinates across multiple functional areas and organizations to ensure integrated EXPRESS Rack and subrack products and hardware are complete, accurate, on time, safe, and certified for flight. NASA is planning to expand the EXPRESS payload capacity by developing new Basic Express Racks expected to be on ISS in 2018.

The International Space Station as a Research Laboratory: A View to 2010 and Beyond

NASA Technical Reports Server (NTRS)

Uri, John J.; Sotomayor, Jorge L.

2007-01-01

Assembly of International Space Station (ISS) is expected to be complete in 2010, with operations planned to continue through at least 2016. As we move nearer to assembly complete, replanning activities by NASA and ISS International Partners have been completed and the final complement of research facilities on ISS is becoming more certain. This paper will review pans for facilities in the US On-orbit Segment of ISS, including contributions from International Partners, to provide a vision of the research capabilities that will be available starting in 2010. At present, in addition to research capabilities in the Russian segment, the United States Destiny research module houses nine research facilities or racks. These facilities include five multi-purpose EXPRESS racks, two Human Research Facility (HRF) racks, the Microgravity Science Glovebox (MSG), and the Minus Eighty-degree Laboratory Freezer for ISS (MELFI), enabling a wide range of exploration-related applied as well as basic research. In the coming years, additional racks will be launched to augment this robust capability: Combustion Integrated Rack (CIR), Fluids Integrated Rack (FIR), Window Observation Rack Facility (WORF), Microgravity Science Research Rack (MSRR), Muscle Atrophy Research Exercise System (MARES), additional EXPRESS racks and possibly a second MELFI. In addition, EXPRESS Logistics Carriers (ELC) will provide attach points for external payloads. The European Space Agency s Columbus module will contain five research racks and provide four external attach sites. The research racks are Biolab, European Physiology Module (EPM), Fluid Science Lab (FSL), European Drawer System (EDS) and European Transport Carrier (ETC). The Japanese Kibo elements will initially support three research racks, Ryutai for fluid science, Saibo for cell science, and Kobairo for materials research, as well as 10 attachment sites for external payloads. As we look ahead to assembly complete, these new facilities represent a threefold increase from the current research laboratory infrastructure on ISS. In addition, the increase in resident crew size will increase from three to six in 2009, will provide the long-term capacity for completing research on board ISS. Transportation to and from ISS for crew and cargo will be provided by a fleet of vehicles from the United States, Russia, ESA and Japan, including accommodations for thermally-conditioned cargo. The completed ISS will have robust research accommodations to support the multidisciplinary research objective of scientists worldwide.

Artificial genetic selection for an efficient translation initiation site for expression of human RACK1 gene in Escherichia coli

PubMed Central

Zhelyabovskaya, Olga B.; Berlin, Yuri A.; Birikh, Klara R.

2004-01-01

In bacterial expression systems, translation initiation is usually the rate limiting and the least predictable stage of protein synthesis. Efficiency of a translation initiation site can vary dramatically depending on the sequence context. This is why many standard expression vectors provide very poor expression levels of some genes. This notion persuaded us to develop an artificial genetic selection protocol, which allows one to find for a given target gene an individual efficient ribosome binding site from a random pool. In order to create Darwinian pressure necessary for the genetic selection, we designed a system based on translational coupling, in which microorganism survival in the presence of antibiotic depends on expression of the target gene, while putting no special requirements on this gene. Using this system we obtained superproducing constructs for the human protein RACK1 (receptor for activated C kinase). PMID:15034151

1400164

NASA Image and Video Library

2014-03-10

ELEASA WILSON, KRAIG TERSIGNI, JUSTIN CARTLEDGE MISSION OPERATIONS LABORATORY - LABORATORY TRAINING COMPLEX (LTC), BUILDING 4663, EXPRESS RACK TRAINING, EMERALD BRICK (POWER DISTRIBUTION FOR EXPRESS RACK LAPTOP).

RACK1 promotes radiation resistance in esophageal cancer via regulating AKT pathway and Bcl-2 expression.

PubMed

Liu, Bowen; Wang, Cong; Chen, Pengxiang; Wang, Lu; Cheng, Yufeng

2017-09-23

RACK1 is a seven Trp-Asp 40 repeat protein, which interacts with a wide range of kinases and proteins. RACK1 plays an important role in the proliferation and progression of various cancers. The aim of this study is to detect the role of RACK1 in the radioresistance in esophageal cancer. The results indicated that downregulation of RACK1 reduced the colony formation ability, proliferation ability and resistance of cells to radiation effection through regulating the radiation-related proteins including pAKT, Bcl-2 and Bim; whereas upregulation of RACK1 promoted the ability and radioresistance of ESCC cells. Our findings suggest that RACK1 promotes proliferation and radioresistance in ESCC cells by activating the AKT pathway, upregulating Bcl-2 expression and downregulating protein levels of Bim. Our study fills in gaps in the field of RACK1 and radiation resistance and may provide new possibilities for improving strategies of radiotherapy in esophageal cancer. Copyright © 2017 Elsevier Inc. All rights reserved.

Kale BoRACK1 is involved in the plant response to salt stress and Peronospora brassicae Gaumann.

PubMed

Li, Da-Hong; Shen, Fu-Jia; Li, Hong-Yan; Li, Wei

2017-06-01

The receptor for activated C kinase 1 (RACK1) belongs to a protein subfamily containing a tryptophan-aspartic acid-domain (WD) repeat structure. Compelling evidence indicates that RACK1 can interact with many signal molecules and affect different signal transduction pathways. In this study, a kale (Brassica oleracea var. acephala f.tricolor) RACK1 gene (BoRACK1) was cloned by RT-PCR. The amino acid sequence of BoRACK1 had seven WD repeats in which there were typical GH (glycine-histidine) and WD dipeptides. Comparison with AtRACK1 from Arabidopsis revealed 87.1% identity at the amino acid level. Expression pattern analysis by RT-PCR showed that BoRACK1 was expressed in all analyzed tissues of kale and that its transcription in leaves was down-regulated by salt, abscisic acid, and H 2 O 2 at a high concentration. Overexpression of BoRACK1 in kale led to a reduction in symptoms caused by Peronospora brassicae Gaumann on kale leaves. The expression levels of the pathogenesis-related protein genes, PR-1 and PRB-1, increased 2.5-4-fold in transgenic kale, and reactive oxygen species production was more active than in the wild-type. They also exhibited increased tolerance to salt stress in seed germination. H 2 O 2 may also be involved in the regulation of BoRACK1 during seed germination under salt stress. Quantitative real-time PCR analyses showed that the transcript levels of BoRbohs genes were significantly higher in overexpression of BoRACK1 transgenic lines. Yeast two-hybrid assays showed that BoRACK1 could interact with WNK8, eIF6, RAR1, and SGT1. This study and previous work lead us to believe that BoRACK1 may form a complex with regulators of plant salt and disease resistance to coordinate kale reactions to pathogens. Copyright © 2017 Elsevier GmbH. All rights reserved.

RACK1 forms a complex with FGFR1 and PKM2, and stimulates the growth and migration of squamous lung cancer cells.

PubMed

Zhou, Chengzhi; Chen, Tao; Xie, Zhanhong; Qin, Yinyin; Ou, Yangming; Zhang, Jiexia; Li, Shiyue; Chen, Rongchang; Zhong, Nanshan

2017-11-01

Phosphorylation of Pyruvate Kinase M2 (PKM2) on Tyr105 by fibroblast growth factor receptor 1 (FGFR1) has been shown to promote its nuclear localization as well as cell growth in lung cancer. Better understanding the regulation of this process would benefit the clinical treatment for lung cancer. Here, it has been found that the adaptor protein receptor for activated PKC kinase (RACK1) formed a complex with FGFR1 and PKM2, and activated the FGFR1/PKM2 signaling. Knocking down the expression of RACK1 impaired the phosphorylation on Tyr105 of PKM2 and inhibited the growth and migration of lung cancer cells, while over-expression of RACK1 in lung cancer cells led to the resistance to Erdafitinib. Moreover, knocking down the expression of RACK1 impaired the tumorigenesis of lung cancer driven by LKB loss and mutated Ras (KrasG12D). Taken together, our study demonstrated the pivotal roles of RACK1 in FGFR1/PKM2 signaling, suggesting FGFR1/RACK1/PKM2 might be a therapeutic target for lung cancer treatment. © 2017 Wiley Periodicals, Inc.

RACK1 is required for adipogenesis.

PubMed

Kong, Qinghua; Gao, Lan; Niu, Yanfen; Gongpan, Pianchou; Xu, Yuhui; Li, Yan; Xiong, Wenyong

2016-11-01

Adipose tissue plays a critical role in metabolic diseases and the maintenance of energy homeostasis. RACK1 has been identified as an adaptor protein involved in multiple intracellular signal transduction pathways and diseases. However, whether it regulates adipogenesis remains unknown. Here, we reported that RACK1 is expressed in 3T3-L1 cells and murine white adipose tissue and that RACK1 knockdown by shRNA profoundly suppressed adipogenesis by reducing the expression of PPAR-γ and C/EBP-β. Depletion of RACK1 increased β-catenin protein levels and activated Wnt signaling. Furthermore, RACK1 knockdown also suppressed the PI3K-Akt-mTOR-S6K signaling pathway by reducing the PI3K p85α, pAkt T473, and S6K p70. Taken together, these results demonstrate that RACK1 is a novel factor required for adipocyte differentiation by emerging Wnt/β-catenin signaling and PI3K-Akt-mTOR-S6K signaling pathway(s). Copyright © 2016 the American Physiological Society.

International Space Station (ISS)

NASA Image and Video Library

2001-02-01

The Payload Operations Center (POC) is the science command post for the International Space Station (ISS). Located at NASA's Marshall Space Flight Center in Huntsville, Alabama, it is the focal point for American and international science activities aboard the ISS. The POC's unique capabilities allow science experts and researchers around the world to perform cutting-edge science in the unique microgravity environment of space. The POC is staffed around the clock by shifts of payload flight controllers. At any given time, 8 to 10 flight controllers are on consoles operating, plarning for, and controlling various systems and payloads. This photograph shows a Payload Rack Officer (PRO) at a work station. The PRO is linked by a computer to all payload racks aboard the ISS. The PRO monitors and configures the resources and environment for science experiments including EXPRESS Racks, multiple-payload racks designed for commercial payloads.

Automated Scalable Heat Shock Modification for Standard Aquatic Housing Systems.

PubMed

Saera-Vila, Alfonso; Kish, Phillip E; Kahana, Alon

2015-08-01

Heat shock is a common technique for inducible gene expression system in a variety of organisms. Heat shock treatment of adult zebrafish is more involved and generally consists of manually transferring fish between housing rack tanks and preheated water tanks or the use of timed heaters in stand-alone aquaria. To avoid excessive fish handling and to take advantage of the continuous flow of a standard housing rack, proposed modifications consisted of installing an aquarium heater inside each tank, manually setting the heater to reach heat shocking temperatures (> 37°C) and, after that, testing that every tank responded equally. To address the limitations in the existing systems, we developed a novel modification of standard zebrafish housing racks to perform heat shock treatment in conditions of continuous water flow. By adding an extra manifold to the housing rack and connecting it to a recirculating bath to create a parallel water flow system, we can increase the temperature from standard conditions (28.5°C) to heat shock conditions with high precision (38.0-38.3°C, mean ± SD = 38.1°C ± 0.14°C) and minimal variation among experimental tanks (coefficient of variation [CV] = 0.04%). This means that there is virtually no need for laborious pretreatment calibrations or continuous adjustments to minimize intertank variation. To test the effectiveness of our design, we utilized this system to induce enhanced green fluorescent protein (EGFP) expression in hsp70-EGFP fish and performed a fin regeneration experiment with hsp70l:dnfgfr1-EGFP fish to confirm that heat-induced gene expression reached physiological levels. In summary, our newly described aquatic heat shock system minimizes effort during heat shock experiments, while ensuring the best water quality and fish welfare and facilitating large heat shock settings or the use of multiple transgenic lines for both research and teaching experiments.

Automated Scalable Heat Shock Modification for Standard Aquatic Housing Systems

PubMed Central

Saera-Vila, Alfonso; Kish, Phillip E.

2015-01-01

Abstract Heat shock is a common technique for inducible gene expression system in a variety of organisms. Heat shock treatment of adult zebrafish is more involved and generally consists of manually transferring fish between housing rack tanks and preheated water tanks or the use of timed heaters in stand-alone aquaria. To avoid excessive fish handling and to take advantage of the continuous flow of a standard housing rack, proposed modifications consisted of installing an aquarium heater inside each tank, manually setting the heater to reach heat shocking temperatures (>37°C) and, after that, testing that every tank responded equally. To address the limitations in the existing systems, we developed a novel modification of standard zebrafish housing racks to perform heat shock treatment in conditions of continuous water flow. By adding an extra manifold to the housing rack and connecting it to a recirculating bath to create a parallel water flow system, we can increase the temperature from standard conditions (28.5°C) to heat shock conditions with high precision (38.0–38.3°C, mean±SD=38.1°C±0.14°C) and minimal variation among experimental tanks (coefficient of variation [CV]=0.04%). This means that there is virtually no need for laborious pretreatment calibrations or continuous adjustments to minimize intertank variation. To test the effectiveness of our design, we utilized this system to induce enhanced green fluorescent protein (EGFP) expression in hsp70-EGFP fish and performed a fin regeneration experiment with hsp70l:dnfgfr1-EGFP fish to confirm that heat-induced gene expression reached physiological levels. In summary, our newly described aquatic heat shock system minimizes effort during heat shock experiments, while ensuring the best water quality and fish welfare and facilitating large heat shock settings or the use of multiple transgenic lines for both research and teaching experiments. PMID:25942613

Characterization of receptor of activated C kinase 1 (RACK1) and functional analysis during larval metamorphosis of the oyster Crassostrea angulata.

PubMed

Yang, Bingye; Pu, Fei; Qin, Ji; You, Weiwei; Ke, Caihuan

2014-03-10

During a large-scale screen of the larval transcriptome library of the Portuguese oyster, Crassostrea angulata, the oyster gene RACK, which encodes a receptor of activated protein kinase C protein was isolated and characterized. The cDNA is 1,148 bp long and has a predicted open reading frame encoding 317 aa. The predicted protein shows high sequence identity to many RACK proteins of different organisms including molluscs, fish, amphibians and mammals, suggesting that it is conserved during evolution. The structural analysis of the Ca-RACK1 genomic sequence implies that the Ca-RACK1 gene has seven exons and six introns, extending approximately 6.5 kb in length. It is expressed ubiquitously in many oyster tissues as detected by RT-PCR analysis. The Ca-RACK1 mRNA expression pattern was markedly increased at larval metamorphosis; and was further increased along with Ca-RACK1 protein synthesis during epinephrine-induced metamorphosis. These results indicate that the Ca-RACK1 plays an important role in tissue differentiation and/or in cell growth during larval metamorphosis in the oyster, C. angulata. Copyright © 2013 Elsevier B.V. All rights reserved.

OsRACK1 Is Involved in Abscisic Acid- and H2O2-Mediated Signaling to Regulate Seed Germination in Rice (Oryza sativa, L.)

PubMed Central

Zhang, Dongping; Chen, Li; Li, Dahong; Lv, Bing; Chen, Yun; Chen, Jingui; XuejiaoYan; Liang, Jiansheng

2014-01-01

The receptor for activated C kinase 1 (RACK1) is one member of the most important WD repeat–containing family of proteins found in all eukaryotes and is involved in multiple signaling pathways. However, compared with the progress in the area of mammalian RACK1, our understanding of the functions and molecular mechanisms of RACK1 in the regulation of plant growth and development is still in its infancy. In the present study, we investigated the roles of rice RACK1A gene (OsRACK1A) in controlling seed germination and its molecular mechanisms by generating a series of transgenic rice lines, of which OsRACK1A was either over-expressed or under-expressed. Our results showed that OsRACK1A positively regulated seed germination and negatively regulated the responses of seed germination to both exogenous ABA and H2O2. Inhibition of ABA biosynthesis had no enhancing effect on germination, whereas inhibition of ABA catabolism significantly suppressed germination. ABA inhibition on seed germination was almost fully recovered by exogenous H2O2 treatment. Quantitative analyses showed that endogenous ABA levels were significantly higher and H2O2 levels significantly lower in OsRACK1A-down regulated transgenic lines as compared with those in wildtype or OsRACK1A-up regulated lines. Quantitative real-time PCR analyses showed that the transcript levels of OsRbohs and amylase genes, RAmy1A and RAmy3D, were significantly lower in OsRACK1A-down regulated transgenic lines. It is concluded that OsRACK1A positively regulates seed germination by controlling endogenous levels of ABA and H2O2 and their interaction. PMID:24865690

RACK1 upregulation induces neuroprotection by activating the IRE1-XBP1 signaling pathway following traumatic brain injury in rats.

PubMed

Ni, Haibo; Rui, Qin; Xu, Yitian; Zhu, Jun; Gao, Fan; Dang, Baoqi; Li, Di; Gao, Rong; Chen, Gang

2018-06-01

Receptor for activated protein kinase C 1 (RACK1) is a multifaceted scaffolding protein known to be involved in the regulation of signaling events required for neuronal protection. In the present study, we investigated the role of RACK1 in secondary brain injury in a rat traumatic brain injury (TBI) model. A weight-drop TBI model was established in Sprague Dawley rats, and RACK1 in vivo knockdown and overexpression were performed 24 h before TBI insult. The IRE1 inhibitor 3,5-dibromosalicylaldehyde (DBSA) was administered by intracerebroventricular injection 1 h after TBI insult. Real-time PCR, Western blotting, immunofluorescence, neuronal apoptosis, brain water content, and neurological scores were evaluated. Our results revealed that TBI induced increased expression of endogenous RACK1, phosphorylated inositol-requiring enzyme 1 (p-IRE1), X-box binding protein-1 (XBP1) and glucose-regulated protein 78 (GRP78) in neurons. RACK1 overexpression significantly ameliorated neuronal apoptosis, blood-brain barrier disruption, brain edema and neurological deficits at 48 h after TBI, which was concomitant with upregulation of p-IRE1, XBP1 and GRP78 expression, while its knockdown induced the opposite effects. Furthermore, DBSA administration reversed the protective effects of RACK1 overexpression against brain injury and decreased the expression of p-IRE1, XBP1 and GRP78. In summary, the upregulation of RACK1 following brain contusion exerted neuroprotective effects against secondary brain injury, which were probably mediated by activation of the IRE1-XBP1 pathway. Copyright © 2018. Published by Elsevier Inc.

Transcription analysis in the MeLiM swine model identifies RACK1 as a potential marker of malignancy for human melanocytic proliferation.

PubMed

Egidy, Giorgia; Julé, Sophia; Bossé, Philippe; Bernex, Florence; Geffrotin, Claudine; Vincent-Naulleau, Silvia; Horak, Vratislav; Sastre-Garau, Xavier; Panthier, Jean-Jacques

2008-04-28

Metastatic melanoma is a severe disease. Few experimental animal models of metastatic melanoma exist. MeLiM minipigs exhibit spontaneous melanoma. Cutaneous and metastatic lesions are histologically similar to human's. However, most of them eventually spontaneously regress. Our purpose was to investigate whether the MeLiM model could reveal markers of malignancy in human melanocytic proliferations. We compared the serial analysis of gene expression (SAGE) between normal pig skin melanocytes and melanoma cells from an early pulmonary metastasis of MeLiM minipigs. Tag identification revealed 55 regulated genes, including GNB2L1 which was found upregulated in the melanoma library. In situ hybridisation confirmed GNB2L1 overexpression in MeLiM melanocytic lesions. GNB2L1 encodes the adaptor protein RACK1, recently shown to influence melanoma cell lines tumorigenicity. We studied the expression of RACK1 by immunofluorescence and confocal microscopy in tissues specimens of normal skin, in cutaneous and metastatic melanoma developped in MeLiM minipigs and in human patients. In pig and human samples, the results were similar. RACK1 protein was not detected in normal epidermal melanocytes. By contrast, RACK1 signal was highly increased in the cytoplasm of all melanocytic cells of superficial spreading melanoma, recurrent dermal lesions and metastatic melanoma. RACK1 partially colocalised with activated PKCalphabeta. In pig metastases, additional nuclear RACK1 did not associate to BDNF expression. In human nevi, the RACK1 signal was low. RACK1 overexpression detected in situ in human melanoma specimens characterized cutaneous and metastatic melanoma raising the possibility that RACK1 can be a potential marker of malignancy in human melanoma. The MeLiM strain provides a relevant model for exploring mechanisms of melanocytic malignant transformation in humans. This study may contribute to a better understanding of melanoma pathophysiology and to progress in diagnosis.

Transcription analysis in the MeLiM swine model identifies RACK1 as a potential marker of malignancy for human melanocytic proliferation

PubMed Central

Egidy, Giorgia; Julé, Sophia; Bossé, Philippe; Bernex, Florence; Geffrotin, Claudine; Vincent-Naulleau, Silvia; Horak, Vratislav; Sastre-Garau, Xavier; Panthier, Jean-Jacques

2008-01-01

Background Metastatic melanoma is a severe disease. Few experimental animal models of metastatic melanoma exist. MeLiM minipigs exhibit spontaneous melanoma. Cutaneous and metastatic lesions are histologically similar to human's. However, most of them eventually spontaneously regress. Our purpose was to investigate whether the MeLiM model could reveal markers of malignancy in human melanocytic proliferations. Results We compared the serial analysis of gene expression (SAGE) between normal pig skin melanocytes and melanoma cells from an early pulmonary metastasis of MeLiM minipigs. Tag identification revealed 55 regulated genes, including GNB2L1 which was found upregulated in the melanoma library. In situ hybridisation confirmed GNB2L1 overexpression in MeLiM melanocytic lesions. GNB2L1 encodes the adaptor protein RACK1, recently shown to influence melanoma cell lines tumorigenicity. We studied the expression of RACK1 by immunofluorescence and confocal microscopy in tissues specimens of normal skin, in cutaneous and metastatic melanoma developped in MeLiM minipigs and in human patients. In pig and human samples, the results were similar. RACK1 protein was not detected in normal epidermal melanocytes. By contrast, RACK1 signal was highly increased in the cytoplasm of all melanocytic cells of superficial spreading melanoma, recurrent dermal lesions and metastatic melanoma. RACK1 partially colocalised with activated PKCαβ. In pig metastases, additional nuclear RACK1 did not associate to BDNF expression. In human nevi, the RACK1 signal was low. Conclusion RACK1 overexpression detected in situ in human melanoma specimens characterized cutaneous and metastatic melanoma raising the possibility that RACK1 can be a potential marker of malignancy in human melanoma. The MeLiM strain provides a relevant model for exploring mechanisms of melanocytic malignant transformation in humans. This study may contribute to a better understanding of melanoma pathophysiology and to progress in diagnosis. PMID:18442364

RACK1 interacts with filamin-A to regulate plasma membrane levels of the cystic fibrosis transmembrane conductance regulator

PubMed Central

Smith, Laura; Litman, Paul; Kohli, Ekta; Amick, Joseph; Page, Richard C.; Misra, Saurav

2013-01-01

Mutations in cystic fibrosis transmembrane regulator (CFTR), a chloride channel in the apical membranes of secretory epithelial cells, underlie the fatal genetic disorder cystic fibrosis. Certain CFTR mutations, including the common mutation ΔF508-CFTR, result in greatly decreased levels of active CFTR at the apical membrane. Direct interactions between CFTR and the cytoskeletal adaptors filamin-A (FlnA) and Na+/H+ exchanger regulatory factor 1 (NHERF1) stabilize the expression and localization of CFTR at the plasma membrane. The scaffold protein receptor for activated C kinase 1 (RACK1) also stabilizes CFTR surface expression; however, RACK1 does not interact directly with CFTR and its mechanism of action is unknown. In the present study, we report that RACK1 interacts directly with FlnA in vitro and in a Calu-3 airway epithelial cell line. We mapped the interaction between RACK1 and FlnA to the WD4 and WD6 repeats of RACK1 and to a segment of the large rod domain of FlnA, consisting of immunoglobulin-like repeats 8–15. Disruption of the RACK1-FlnA interaction causes a reduction in CFTR surface levels. Our results suggest that a novel RACK1-FlnA interaction is an important regulator of CFTR surface localization. PMID:23636454

RACK-1 regulates let-7 microRNA expression and terminal cell differentiation in Caenorhabditis elegans

PubMed Central

Chu, Yu-De; Wang, Wei-Chieh; Chen, Shi-An A; Hsu, Yen-Ting; Yeh, Meng-Wei; Slack, Frank J; Chan, Shih-Peng

2014-01-01

The let-7 microRNA (miRNA) regulates cell cycle exit and terminal differentiation in the C. elegans heterochronic gene pathway. Low expression of let-7 results in retarded vulva and hypodermal cell development in C. elegans and has been associated with several human cancers. Previously, the versatile scaffold protein receptor for activated C kinase 1 (RACK1) was proposed to facilitate recruitment of the miRNA-induced silencing complex (miRISC) to the polysome and to be required for miRNA function in C. elegans and humans. Here, we show that depletion of C. elegans RACK-1 by RNAi increases let-7 miRNA levels and suppresses the retarded terminal differentiation of lateral hypodermal seam cells in mutants carrying the hypomorphic let-7(n2853) allele or lacking the let-7 family miRNA genes mir-48 and mir-241. Depletion of RACK-1 also increases the levels of precursor let-7 miRNA. When Dicer is knocked down and pre-miRNA processing is inhibited, depletion of RACK-1 still leads to increased levels of pre-let-7, suggesting that RACK-1 affects a biogenesis mechanism upstream of Dicer. No changes in the activity of the let-7 promoter or the levels of primary let-7 miRNA are associated with depletion of RACK-1, suggesting that RACK-1 affects let-7 miRNA biogenesis at the post-transcriptional level. Interestingly, rack-1 knockdown also increases the levels of a few other precursor miRNAs. Our results reveal that RACK-1 controls the biogenesis of a subset of miRNAs, including let-7, and in this way plays a role in the heterochronic gene pathway during C. elegans development. PMID:24776851

RACK1 regulates mesenchymal cell recruitment during sexual and asexual reproduction of budding tunicates.

PubMed

Tatzuke, Yuki; Sunanaga, Takeshi; Fujiwara, Shigeki; Kawamura, Kaz

2012-08-15

A homolog of receptor for activated protein kinase C1 (RACK1) was cloned from the budding tunicate Polyandrocarpa misakiensis. By RT-PCR and in situ hybridization analyses, PmRACK1 showed biphasic gene expression during asexual and sexual reproduction. In developing buds, the signal was exclusively observed in the multipotent atrial epithelium and undifferentiated mesenchymal cells that contributed to morphogenesis by the mesenchymal-epithelial transition (MET). In juvenile zooids, the signal was first observable in germline precursor cells that arose as mesenchymal cell aggregated in the ventral hemocoel. In mature zooids, the germinal epithelium in the ovary and the pharynx were the most heavily stained parts. GFP reporter assay indicated that the ovarian expression of PmRACK1 was constitutive from germline precursor cells to oocytes. To elucidate the in vivo function of PmRACK1, RNA interference was challenged. When growing buds were incubated with 5 nmol/mL siRNA, most mesenchymal cells remained round and appeared to have no interactions with the extracellular matrix (ECM), causing lower activity of MET without any apparent effects on cell proliferation. The resultant zooids became growth-deficient. The dwarf zooids did not form buds or mature gonads. Prior to RNAi, buds were treated with human BMP4 that could induce PmRACK1 expression, which resulted in MET activity. We conclude that in P. misakiensis, PmRACK1 plays roles in mesenchymal cell recruitment during formation of somatic and gonad tissues, which contributes to zooidal growth and sexual and asexual reproduction. Copyright © 2012 Elsevier Inc. All rights reserved.

Microgravity

NASA Image and Video Library

1998-01-01

Engineering mockup shows the general arrangement of the plarned Biotechnology Facility inside an EXPRESS rack aboard the International Space Station. This layout includes a gas supply module (bottom left), control computer and laptop interface (bottom right), two rotating wall vessels (top right), and support systems.

Noncontact rack-pinion-rack device as a differential vibration sensor.

PubMed

Miri, MirFaez; Nasiri, Mojtaba

2010-07-01

We study a nanoscale system composed of one corrugated cylinder (pinion) placed between two corrugated plates (racks). The pinion and racks have no mechanical contact, but are coupled via the lateral Casimir force-one of the most spectacular consequences of quantum fluctuations of the electromagnetic field. The noncontact design of the device could help with the noteworthy wear problem in nanoscale mechanical systems. We consider the case where both racks undergo harmonic lateral motion. We assume that the amplitude, frequency, and phase of one of the racks are known. We show that probing the pinion motion, one can determine the vibration characteristics of the other rack.

White House Communications Agency (WHCA) Presidential Voice Communications Rack Mount System Mechanical Drawing Package

DTIC Science & Technology

2015-12-01

Rack Mount System Mechanical Drawing Package by Steven P Callaway Approved for public release; distribution unlimited...Laboratory White House Communications Agency (WHCA) Presidential Voice Communications Rack Mount System Mechanical Drawing Package by Steven P...Note 3. DATES COVERED (From - To) 04/2013 4. TITLE AND SUBTITLE White House Communications Agency (WHCA) Presidential Voice Communications Rack

ISS Expedition 18 Fluids and Combustion Facility (FCF) Combustion Integration Rack (CIR) Passive Rack Isolation System (

NASA Image and Video Library

2009-01-05

ISS018-E-017796 (5 Jan. 2009) --- Astronaut Sandra Magnus, Expedition 18 flight engineer, works on the Fluids and Combustion Facility (FCF) Combustion Integration Rack (CIR) Passive Rack Isolation System (PaRIS) in the Destiny laboratory of the International Space Station.

Biotechnology Facility (BTF) for ISS

NASA Technical Reports Server (NTRS)

1998-01-01

Engineering mockup shows the general arrangement of the plarned Biotechnology Facility inside an EXPRESS rack aboard the International Space Station. This layout includes a gas supply module (bottom left), control computer and laptop interface (bottom right), two rotating wall vessels (top right), and support systems.

STS-114 Crew Interviews Eileen Collins, CDR

NASA Technical Reports Server (NTRS)

2003-01-01

Commander Eileen Collins of the STS-114 space mission is seen during a pre-launch interview. She answers questions about the primary goals of the mission which are to exchange the expedition six and expedition seven crews. Also, she says that a large amount of logistics will be taken up to the International Space Station. The primary payload on this mission include: 1) The Utilization and Logistics Flight-1 (ULF-1); 2) Raffaello Multi-Purpose Logistics Module (MPLM); and 3) External Stowage Platform (ESP-2) which are all explained in detail by the Commander. The Window Observational Research Facility (WORF) rack, Human Research Facility (HRF) rack, Minus Eighty Degree Laboratory Freezer (MELF) and EXPRESS rack are the Space Station equipment to be installed on the International Space Station (I.S.S.). Collins is the Intravehicular Activity (IVA) specialist for this mission who oversees the three Extravehicular Activity (EVA)'s performed by Mission Specialists Soichi Noguchi and Stephen Robinson. The three EVA's include an external camera installation, positioning devices for an ammonia system and the installation of Floating Potential Measuring Unit (FPMU). Commander Collins expresses that she wants to have a successful mission, and also wants to see the Earth from space.

The role of HSP27 in RACK1-mediated PKC activation in THP-1 cells.

PubMed

Corsini, Emanuela; Galbiati, Valentina; Papale, Angela; Kummer, Elena; Pinto, Antonella; Guaita, Antonio; Racchi, Marco

2016-08-01

Receptor for Activated C Kinase 1 (RACK1) pseudosubstrate is a commercially available peptide that directly activates protein kinase C-β (PKCβ). We have recently shown that RACK1 pseudosubstrate, alone or in combination with classical immune activators, results in increased cytokine production and CD86 upregulation in primary leukocytes. Furthermore, we demonstrated a role of PKCβ and RACK1 in chemical allergen-induced CD86 expression and IL-8 production in both THP-1 cells and primary human dendritic cells. Aim of this study was to shed light on the mechanisms underlying RACK1 pseudosubstrate-induced immune activation and to compare it to lipopolysaccharide (LPS). The human promyelocytic cell line THP-1 was used throughout the study. RACK1 pseudosubstrate induced rapid (5 min) and dose-related PKCβ activation as assessed by its membrane translocation. Among the proteins phosphorylated, we identified Hsp27. Both RACK1 pseudosubstrate and LPS induce its phosphorylation and release in culture medium. The release of Hsp27 induced by RACK1 pseudosubstrate was also confirmed in peripheral blood mononuclear cells. To evaluate the role of Hsp27 in RACK1 pseudosubstrate or LPS-induced cell activation, we conducted Hsp27 silencing and neutralization experiments. Both strategies confirmed the central role of Hsp27 in RACK1 pseudosubstrate or LPS-induced cell activation, as assessed by IL-8 production and upregulation of CD86.

The interaction of protein-tyrosine phosphatase α (PTPα) and RACK1 protein enables insulin-like growth factor 1 (IGF-1)-stimulated Abl-dependent and -independent tyrosine phosphorylation of PTPα.

PubMed

Khanna, Ranvikram S; Le, Hoa T; Wang, Jing; Fung, Thomas C H; Pallen, Catherine J

2015-04-10

Protein tyrosine phosphatase α (PTPα) promotes integrin-stimulated cell migration in part through the role of Src-phosphorylated PTPα-Tyr(P)-789 in recruiting and localizing p130Cas to focal adhesions. The growth factor IGF-1 also stimulates PTPα-Tyr-789 phosphorylation to positively regulate cell movement. This is in contrast to integrin-induced PTPα phosphorylation, that induced by IGF-1 can occur in cells lacking Src family kinases (SFKs), indicating that an unknown kinase distinct from SFKs can target PTPα. We show that this IGF-1-stimulated tyrosine kinase is Abl. We found that PTPα binds to the scaffold protein RACK1 and that RACK1 coordinates the IGF-1 receptor, PTPα, and Abl in a complex to enable IGF-1-stimulated and Abl-dependent PTPα-Tyr-789 phosphorylation. In cells expressing SFKs, IGF-1-stimulated phosphorylation of PTPα is mediated by RACK1 but is Abl-independent. Furthermore, expressing the SFKs Src and Fyn in SFK-deficient cells switches IGF-1-induced PTPα phosphorylation to occur in an Abl-independent manner, suggesting that SFK activity dominantly regulates IGF-1/IGF-1 receptor signaling to PTPα. RACK1 is a molecular scaffold that integrates growth factor and integrin signaling, and our identification of PTPα as a RACK1 binding protein suggests that RACK1 may coordinate PTPα-Tyr-789 phosphorylation in these signaling networks to promote cell migration. © 2015 by The American Society for Biochemistry and Molecular Biology, Inc.

10 CFR 36.35 - Source rack protection.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 1 2010-01-01 2010-01-01 false Source rack protection. 36.35 Section 36.35 Energy NUCLEAR... Requirements for Irradiators § 36.35 Source rack protection. If the product to be irradiated moves on a product conveyor system, the source rack and the mechanism that moves the rack must be protected by a barrier or...

Crew Member Interface with Space Station Furnace Facility

NASA Technical Reports Server (NTRS)

Cash, Martha B.

1997-01-01

The Space Station Furnace Facility (SSFF) is a facility located in the International Space Station United States Laboratory (ISS US Lab) for materials research in the microgravity environment. The SSFF will accommodate basic research, commercial applications, and studies of phenomena of metals and alloys, electronic and photonic materials, and glasses and ceramics. To support this broad base of research requirements, the SSFF will operate, regulate, and support a variety of Experiment Modules (EMs). To meet station requirements concerning the microgravity level needed for experiments, station is providing an active vibration isolation system, and SSFF provides the interface. SSFF physically consists of a Core Rack and two instrument racks (IRs) that occupy three adjacent ISS US Lab rack locations within the International Space Station (ISS). All SSFF racks are modified International Standard Payload Racks (ISPR). SSFF racks will have a 50% larger pass through area on the lower sides than ISPRs to accommodate the many rack to rack interconnections. The Instrument Racks are further modified with lowered floors and an additional removable panel (15" x 22") on top of the rack for access if needed. The Core Rack shall contain all centralized Core subsystems and ISS subsystem equipment. The two Instrument Racks shall contain the distributed Core subsystem equipment, ISS subsystem equipment, and the EMs. The Core System, which includes the Core Rack, the IR structures, and subsystem components located in the IRs serves as the central control and management for the IRs and the EMs. The Core System receives the resources provided by the International Space Station (ISS) and modifies, allocates, and distributes these resources to meet the operational requirements of the furnace. The Core System is able to support a total of four EMs and can control, support, and activate/deactivate the operations of two EMs, simultaneously. The IRs can be configured to house two small EMs or one tall vertical EM, and serve as the interface between the Core and the respective EM. The Core Rack and an adjacent Instrument Rack (containing one or more furnaces) will be delivered to the ISS in one launch. This is Integrated Configuration One (ICI). The Core Rack and IRI will be passive during transport in the Mini Pressurized Logistics Module (MPLM): Any subsequent EMs to operate within IRI are installed on-orbit. The second IR (containing one or more furnaces) is delivered to ISS on a subsequent launch which will establish Integrated Configuration Two (IC2). Additional integrated configurations will be established with the replacement of EMs or Instrument Racks.

Effectiveness of Rack Sanitation Procedures for Elimination of Bacteria from Automatic Watering Manifolds.

PubMed

Costello, Terry; Watkins, Linda; Straign, Mike; Bean, William; Toth, Linda; Rehg, Jerold

1998-03-01

An important responsibility of animal care programs is to protect research animals from exposure to potentially pathogenic microorganisms. To validate the need for steam sterilization of rodent automatic watering racks, we evaluate the post-sanitation microbial contamination of experimentally inoculated racks and of racks that had been used to house conventional mice. We tested three sanitation protocols: rack-washer sanitation without manifold flush, sanitation that included manifold flush, and sanitation that included manifold flush followed by autoclaving. Rack sanitation, with or without manifold flush, did not reliably eliminate microbial flora from the lixits or manifold drainage water. A total of 43% of all non-autoclaved racks were positive for bacterial contamination after sanitation, and racks that had been used for conventional animal housing were more frequently positive than were experimentally inoculated racks (79% vs 18%). These data indicate that steam sterilization is necessary for eliminating bacteria from automatic watering systems. These observations are particularly important in light of increasing numbers of immune-impaired rodents that may be inadvertently and unnecessarily exposed to microbial pathogens via the automatic watering system.

Information technology equipment cooling method

DOEpatents

Schultz, Mark D.

2015-10-20

According to one embodiment, a system for removing heat from a rack of information technology equipment may include a sidecar indoor air to liquid heat exchanger that cools air utilized by the rack of information technology equipment to cool the rack of information technology equipment. The system may also include a liquid to liquid heat exchanger and an outdoor heat exchanger. The system may further include configurable pathways to connect and control fluid flow through the sidecar heat exchanger, the liquid to liquid heat exchanger, the rack of information technology equipment, and the outdoor heat exchanger based upon ambient temperature and/or ambient humidity to remove heat generated by the rack of information technology equipment.

Method and system for detecting explosives

DOEpatents

Reber, Edward L [Idaho Falls, ID; Jewell, James K [Idaho Falls, ID; Rohde, Kenneth W [Idaho Falls, ID; Seabury, Edward H [Idaho Falls, ID; Blackwood, Larry G [Idaho Falls, ID; Edwards, Andrew J [Idaho Falls, ID; Derr, Kurt W [Idaho Falls, ID

2009-03-10

A method of detecting explosives in a vehicle includes providing a first rack on one side of the vehicle, the rack including a neutron generator and a plurality of gamma ray detectors; providing a second rack on another side of the vehicle, the second rack including a neutron generator and a plurality of gamma ray detectors; providing a control system, remote from the first and second racks, coupled to the neutron generators and gamma ray detectors; using the control system, causing the neutron generators to generate neutrons; and performing gamma ray spectroscopy on spectra read by the gamma ray detectors to look for a signature indicative of presence of an explosive. Various apparatus and other methods are also provided.

Explosives detection system and method

DOEpatents

Reber, Edward L.; Jewell, James K.; Rohde, Kenneth W.; Seabury, Edward H.; Blackwood, Larry G.; Edwards, Andrew J.; Derr, Kurt W.

2007-12-11

A method of detecting explosives in a vehicle includes providing a first rack on one side of the vehicle, the rack including a neutron generator and a plurality of gamma ray detectors; providing a second rack on another side of the vehicle, the second rack including a neutron generator and a plurality of gamma ray detectors; providing a control system, remote from the first and second racks, coupled to the neutron generators and gamma ray detectors; using the control system, causing the neutron generators to generate neutrons; and performing gamma ray spectroscopy on spectra read by the gamma ray detectors to look for a signature indicative of presence of an explosive. Various apparatus and other methods are also provided.

Boeing engineers perform air flow balance testing.

NASA Image and Video Library

2017-10-05

Boeing engineers, Chris Chapman, left, Greg Clark, center, and Ashesh Patel, right, perform air flow balance testing on NASA's new Basic Express Racks. The racks, developed at Marshall, will expand the capabilities for science research aboard the International Space Station. Delivery to the station is scheduled for late 2018.

International Microgravity Plasma Facility IMPF: A Multi-User Modular Research Facility for Complex Plasma Research on ISS

NASA Astrophysics Data System (ADS)

Seurig, R.; Burfeindt, J.; Castegini, R.; Griethe, W.; Hofmann, P.

2002-01-01

On March 03, 2001, the PKE-Nefedov plasma experiment was successfully put into operation on board ISS. This complex plasma experiment is the predecessor for the semi-autonomous multi-user facility IMPF (International Microgravity Plasma Facility) to be flown in 2006 with an expected operational lifetime of 10 years. IMPF is envisioned to be an international research facility for investigators in the field of multi-component plasmas containing ions, electrons, and charged microparticles. This research filed is often referred to as "complex plasmas". The actual location of IMPF on ISS is not decided yet; potential infrastructure under consideration are EXPRESS Rack, Standard Interface Rack SIR, European Drawer Rack EDR, or a to be designed custom rack infrastructure on the Russian Segment. The actual development status of the DLR funded Pre-phase B Study for IMPF will be presented. For this phase, IMPF was assumed to be integrated in an EXPRESS Rack requiring four middeck lockers with two 4-PU ISIS drawers for accommodation. Technical and operational challenges, like a 240 Mbytes/sec continuous experimental data stream for 60 minutes, will be addressed. The project was funded by the German Space Agency (DLR) and was performed in close cooperation with scientists from the Max-Planck-Institute for Extraterrestical Physics in Munich, Germany.

Aircraft Enroute Command and Control Comms Redesign Mechanical Documentation

DTIC Science & Technology

2015-12-01

and power equipment is secured. Custom racks , with 8 server rack bays, are mounted to the pallet, with 2 desk stations for equipment operators...conventional rack equipment. Equipment in the original system was larger and heavier than the new equipment selected for the NG-JC2S. Battery backup was...purposes. The equipment also needed to be easily removable in the event of equipment failure. Surplus rack space available in the NG-JC2S system allowed

Combined Cycle Engine Large-Scale Inlet for Mode Transition Experiments: System Identification Rack Hardware Design

NASA Technical Reports Server (NTRS)

Thomas, Randy; Stueber, Thomas J.

2013-01-01

The System Identification (SysID) Rack is a real-time hardware-in-the-loop data acquisition (DAQ) and control instrument rack that was designed and built to support inlet testing in the NASA Glenn Research Center 10- by 10-Foot Supersonic Wind Tunnel. This instrument rack is used to support experiments on the Combined-Cycle Engine Large-Scale Inlet for Mode Transition Experiment (CCE? LIMX). The CCE?LIMX is a testbed for an integrated dual flow-path inlet configuration with the two flow paths in an over-and-under arrangement such that the high-speed flow path is located below the lowspeed flow path. The CCE?LIMX includes multiple actuators that are designed to redirect airflow from one flow path to the other; this action is referred to as "inlet mode transition." Multiple phases of experiments have been planned to support research that investigates inlet mode transition: inlet characterization (Phase-1) and system identification (Phase-2). The SysID Rack hardware design met the following requirements to support Phase-1 and Phase-2 experiments: safely and effectively move multiple actuators individually or synchronously; sample and save effector control and position sensor feedback signals; automate control of actuator positioning based on a mode transition schedule; sample and save pressure sensor signals; and perform DAQ and control processes operating at 2.5 KHz. This document describes the hardware components used to build the SysID Rack including their function, specifications, and system interface. Furthermore, provided in this document are a SysID Rack effectors signal list (signal flow); system identification experiment setup; illustrations indicating a typical SysID Rack experiment; and a SysID Rack performance overview for Phase-1 and Phase-2 experiments. The SysID Rack described in this document was a useful tool to meet the project objectives.

Information technology equipment cooling system

DOEpatents

Schultz, Mark D.

2014-06-10

According to one embodiment, a system for removing heat from a rack of information technology equipment may include a sidecar indoor air to liquid heat exchanger that cools warm air generated by the rack of information technology equipment. The system may also include a liquid to liquid heat exchanger and an outdoor heat exchanger. The system may further include configurable pathways to connect and control fluid flow through the sidecar heat exchanger, the liquid to liquid heat exchanger, the rack of information technology equipment, and the outdoor heat exchanger based upon ambient temperature and/or ambient humidity to remove heat from the rack of information technology equipment.

System for handling and storing radioactive waste

DOEpatents

Anderson, J.K.; Lindemann, P.E.

1982-07-19

A system and method are claimed for handling and storing spent reactor fuel and other solid radioactive waste, including canisters to contain the elements of solid waste, storage racks to hold a plurality of such canisters, storage bays to store these racks in isolation by means of shielded doors in the bays. This system also includes means for remotely positioning the racks in the bays and an access tunnel within which the remotely operated means is located to position a rack in a selected bay. The modular type of these bays will facilitate the construction of additional bays and access tunnel extension.

System for handling and storing radioactive waste

DOEpatents

Anderson, John K.; Lindemann, Paul E.

1984-01-01

A system and method for handling and storing spent reactor fuel and other solid radioactive waste, including canisters to contain the elements of solid waste, storage racks to hold a plurality of such canisters, storage bays to store these racks in isolation by means of shielded doors in the bays. This system also includes means for remotely positioning the racks in the bays and an access tunnel within which the remotely operated means is located to position a rack in a selected bay. The modular type of these bays will facilitate the construction of additional bays and access tunnel extension.

Opportunities for research on Space Station Freedom

NASA Technical Reports Server (NTRS)

Phillips, Robert W.

1992-01-01

NASA has allocated research accommodations on Freedom (equipment, utilities, etc.) to the program offices that sponsor space-based research and development as follows: Space Science and Applications (OSSA)--52 percent, Commercial Programs (OCP)--28 percent, Aeronautics and Space Technology (OAST)--12 percent, and Space Flight (OSF)--8 percent. Most of OSSA's allocation will be used for microgravity and life science experiments; although OSSA's space physics, astrophysics, earth science and applications, and solar system exploration divisions also will use some of this allocation. Other Federal agencies have expressed an interest in using Space Station Freedom. They include the National Institutes of Health (NIH), U.S. Geological Survey, National Science Foundation, National Oceanic and Atmospheric Administration, and U.S. Departments of Agriculture and Energy. Payload interfaces with space station lab support equipment must be simple, and experiment packages must be highly contained. Freedom's research facilities will feature International Standard Payload Racks (ISPR's), experiment racks that are about twice the size of a Spacelab rack. ESA's Columbus lab will feature 20 racks, the U.S. lab will have 12 racks, and the Japanese lab will have 10. Thus, Freedom will have a total of 42 racks versus 8 for Space lab. NASA is considering outfitting some rack space to accommodate small, self-contained payloads similar to the Get-Away-Special canisters and middeck-locker experiment packages flown on Space Shuttle missions. Crew time allotted to experiments on Freedom at permanently occupied capability will average 25 minutes per rack per day, compared to six hours per rack per day on Spacelab missions. Hence, telescience--the remote operation of space-based experiments by researchers on the ground--will play a very important role in space station research. Plans for supporting life sciences research on Freedom focus on the two basic goals of NASA 's space life sciences program: to ensure the health, safety, and productivity of humans in space and to acquire fundamental knowledge of biological processes. Space-based research has already shown that people and plants respond the same way to the microgravity environment: they lose structure. However, the mechanisms by which they respond are different, and researchers do not yet know much about these mechanisms. Life science research accommodations on Freedom will include facilities for experiments designed to address this and other questions, in fields such as gravitational biology, space physiology, and biomedical monitoring and countermeasures research.

The Interplay Between Hardware and Control System Design in the Development of the Active Rack Isolation System

NASA Technical Reports Server (NTRS)

Fialho, Ian J.; Thampi, Sreekumar

2000-01-01

A primary mission of the International Space Station (ISS) is to provide a premier microgravity laboratory environment for conducting acceleration sensitive scientific research. In order to accomplish this goal, vibroacoustic disturbances caused by station activities that occur during the microgravity mode of operation, must be controlled. In addition to source isolation and other passive isolation methods, the ISS uses active isolation at the receiver, through the use of an Active Rack Isolation System (ARIS), as part of its overall vibration isolation strategy. A schematic diagram of a typical ARIS payload rack is shown. The ARIS isolation control system senses rack acceleration via three triaxial accelerometer heads and uses eight pushrod actuators to perform active vibration attenuation. Position sensors housed in the actuator assembly are used to sense the relative position between the rack and the station. Electrical power, data and other essential resources are routed through a set of umbilicals that interface with a passthrough panel at the bottom of the rack. A representative umbilical set is shown.

Utilizing the US Lab Nadir Research Window for Remote Sensing Operations with The Window Observational Research Facility (WORF)

NASA Technical Reports Server (NTRS)

Turner, Richard; Barley, Bryan; Gilbert, Paul A. (Technical Monitor)

2002-01-01

The Window Observational Research Facility (WORF) is an ISPR-based rack facility designed to take advantage of the high optical quality US Lab Nadir research window. The WORF is based on the ISS Expedite the Processing of Experiments to Space Station (EXPRESS) rack mechanical structure and electronic systems. The WORF has a unique payload volume located at the center of the rack that provides access to the window. The interior dimensions of the payload volume are 34-in. (86.36 cm) wide by 33-in. (83.82 cm) high by 23-in. (58.42 cm) deep. This facility supports the deployment of payloads such as 9 in. aerial photography cameras and 12 in. diameter optical equipment. The WORF coupled with the optical quality of the United States Lab window support the deployment of various payload disciplines. The WORF provides payloads with power, data command and control, air cooling, water cooling, and video processing. The WORF's payload mounting surfaces and interfaces include the interior payload mounting shelf and the interior and exterior aircraft-like seat tracks. The payload mounting shelf is limited to a maximum mass of 136 kg (299 pounds). The WORF can accommodate large payloads such as the commonly used Leica-Heerbrug RC-30 aerial photography camera (whose dimensions are 53.3 cm (21-in.) wide by 50.8 cm (20-in.) deep by 76.2 cm (30-in.) long). The performance characteristics of the WORF allow it to support an array of payload disciplines. The WORF provides a maximum of 3 Kw at 28 Vdc and has a maximum data rate of 10 Mbps. The WORF's unique payload volume is designed to be light-tight, down to 2.8 x 10(exp -11) Watts/cm2/steradian, and have low-reflective surfaces. This specially designed WORF interior supports payload investigations that observe low-light-level phenomenon such as aurora. Although the WORF rack does not employ any active rack isolation (i.e., vibration dampening) technology, the rack provides a very stable environment for payload operations (on the order of X microradians). The facility's software is capable of being updated during its period of deployment. The WORF project also includes a Suitcase Simulator to allow for a payload developer to verify data interfaces at his development site, a trainer rack for astronauts to learn how to operate the WORF prior to flight, and the use of the EXPRESS Functional Checkout Units to allow for payload checkout at the KSC prior to launch.

Updates on HRF Payloads Operations in Columbus ATCS

NASA Technical Reports Server (NTRS)

DePalo, Savino; Wright, Bruce D.; La,e Robert E.; Challis, Simon; Davenport, Robert; Pietrafesa, Donata

2011-01-01

The NASA developed Human Research Facility 1 (HRF1) and Human Research Facility (HRF2) experiment racks have been operating in the European Space Agency (ESA) Columbus module of the International Space Station (ISS) since Summer 2008. The two racks are of the same design. Since the start of operations, unexpected pressure spikes were observed in the Columbus module's thermal-hydraulic system during the racks activation sequence. The root cause of these spikes was identified in the activation command sequence in the Rack Interface Controller (RIC), which controls the flow of thermal-hydraulic system fluid through the rack. A new Common RIC Software (CRS) release fixed the bug and was uploaded on both racks in late 2009. This paper gives a short introduction to the topic, describes the Columbus module countermeasures to mitigate the spikes, describes the ground validation test of the new software, and describes the flight checks performed before and after the final upload. Finally, the new on-orbit test designed to further simplify the racks hydraulic management is presented.

System and method for object localization

NASA Technical Reports Server (NTRS)

Kelly, Alonzo J. (Inventor); Zhong, Yu (Inventor)

2005-01-01

A computer-assisted method for localizing a rack, including sensing an image of the rack, detecting line segments in the sensed image, recognizing a candidate arrangement of line segments in the sensed image indicative of a predetermined feature of the rack, generating a matrix of correspondence between the candidate arrangement of line segments and an expected position and orientation of the predetermined feature of the rack, and estimating a position and orientation of the rack based on the matrix of correspondence.

ARS racks

NASA Image and Video Library

2009-09-22

ISS020-E-041651 (22 Sept. 2009) --- NASA astronaut Michael Barratt works with the Atmosphere Revitalization System (ARS) rack in the Destiny laboratory of the International Space Station. Barratt, Canadian Space Agency astronaut Robert Thirsk (out of frame) and European Space Agency astronaut Frank De Winne (out of frame), all Expedition 20 flight engineers, spent several hours with the extensive dual-rack swap/install activity, to move Destiny?s ARS rack to the Kibo laboratory and install in Destiny in its place the newly-delivered ARS rack for Node-3.

ARS racks

NASA Image and Video Library

2009-09-22

ISS020-E-041647 (22 Sept. 2009) --- NASA astronaut Michael Barratt works with the Atmosphere Revitalization System (ARS) rack in the Destiny laboratory of the International Space Station. Barratt, Canadian Space Agency astronaut Robert Thirsk (out of frame) and European Space Agency astronaut Frank De Winne (out of frame), all Expedition 20 flight engineers, spent several hours with the extensive dual-rack swap/install activity, to move Destiny?s ARS rack to the Kibo laboratory and install in Destiny in its place the newly-delivered ARS rack for Node-3.

RACK1-mediated translation control promotes liver fibrogenesis

DOE Office of Scientific and Technical Information (OSTI.GOV)

Liu, Min; Peng, Peike; Wang, Jiajun

Activation of quiescent hepatic stellate cells (HSCs) is the central event of liver fibrosis. The translational machinery is an optimized molecular network that affects cellular homoeostasis and diseases, whereas the role of protein translation in HSCs activation and liver fibrosis is little defined. Our previous report suggests that up-regulation of receptor for activated C-kinase 1(RACK1) in HSCs is critical for liver fibrogenesis. In this study, we found that RACK1 promoted macrophage conditioned medium (MCM)-induced assembly of eIF4F and phosphorylation of eIF4E in primary HSCs. RACK1 enhanced the translation and expression of pro-fibrogenic factors collagen 1α1, snail and cyclin E1 inducedmore » by MCM. Administration of PP242 or knock-down of eIF4E suppressed RACK1-stimulated collagen 1α1 production, proliferation and migration in primary HSCs. In addition, depletion of eIF4E attenuated thioacetamide (TAA)-induced liver fibrosis in vivo. Our data suggest that RACK1-mediated stimulation of cap-dependent translation plays crucial roles in HSCs activation and liver fibrogenesis, and targeting translation initiation could be a promising strategy for the treatment of liver fibrosis. - Highlights: • RACK1 induces the assembly of eIF4F and phosphorylation of eIF4E in primary HSCs. • RACK1 stimulates the translation of collagen 1α1, snail and cyclin E1 in HSCs. • RACK1 promotes HSCs activation via cap-mediated translation. • Depletion of eIF4E suppresses liver fibrogenesis in vivo.« less

Loss of the starvation-induced gene Rack1 leads to glycogen deficiency and impaired autophagic responses in Drosophila.

PubMed

Erdi, Balázs; Nagy, Péter; Zvara, Agnes; Varga, Agnes; Pircs, Karolina; Ménesi, Dalma; Puskás, László G; Juhász, Gábor

2012-07-01

Autophagy delivers cytoplasmic material for lysosomal degradation in eukaryotic cells. Starvation induces high levels of autophagy to promote survival in the lack of nutrients. We compared genome-wide transcriptional profiles of fed and starved control, autophagy-deficient Atg7 and Atg1 null mutant Drosophila larvae to search for novel regulators of autophagy. Genes involved in catabolic processes including autophagy were transcriptionally upregulated in all cases. We also detected repression of genes involved in DNA replication in autophagy mutants compared with control animals. The expression of Rack1 (receptor of activated protein kinase C 1) increased 4.1- to 5.5-fold during nutrient deprivation in all three genotypes. The scaffold protein Rack1 plays a role in a wide range of processes including translation, cell adhesion and migration, cell survival and cancer. Loss of Rack1 led to attenuated autophagic response to starvation, and glycogen stores were decreased 11.8-fold in Rack1 mutant cells. Endogenous Rack1 partially colocalized with GFP-Atg8a and early autophagic structures on the ultrastructural level, suggesting its involvement in autophagosome formation. Endogenous Rack1 also showed a high degree of colocalization with glycogen particles in the larval fat body, and with Shaggy, the Drosophila homolog of glycogen synthase kinase 3B (GSK-3B). Our results, for the first time, demonstrated the fundamental role of Rack1 in autophagy and glycogen synthesis.

Gerst installs CMS-2 in KIBO rack

NASA Image and Video Library

2014-09-09

European Space Agency astronaut Alexander Gerst,Expedition 40 flight engineer,installs a microscope for the Cell Mechanosensing-2 experiment in the Kibo laboratory of the International Space Station. The Japanese experiment,which is conducted in Kibos Kobairo rack,seeks to identify gravity sensors in cells that may change the expression of key proteins and genes and allowing muscles to atrophy in microgravity.

Lessons Learned from the Crew Health Care System (CHeCS) Rack 1 Environmental Control and Life Support (ECLS) Design

NASA Technical Reports Server (NTRS)

Williams, David E.

2006-01-01

This paper will provide an overview of the International Space Station (ISS) Environmental Control and Life Support (ECLS) design of the Crew Health Care System (CHeCS) Rack 1 and it will document some of the lessons that have been learned to date for the ECLS equipment in this rack.

International Space Station (ISS) Expedite the Process of Experiments to Space Station (EXPRESS) Racks Software Support

NASA Technical Reports Server (NTRS)

2003-01-01

bd Systems personnel accomplished the technical responsibilities for this reporting period, as planned. A close working relationship was maintained with personnel of the MSFC Avionics Department Software Group (ED 14), the MSFC EXPRESS Project Office (FD3 l), and the Huntsville Boeing Company. Work accomplishments included the support of SRB activities, ATB activities, ESCP activities, participating in technical meetings, coordinating issues between the Boeing Company and the MSFC Project Office, and performing special tasks as requested.

Window Observational Rack Facility (WORF)

NASA Technical Reports Server (NTRS)

2002-01-01

Developed by Boeing, at the Marshall Space Flight Center (MSFC) Space Station Manufacturing building, the Window Observational Rack Facility (WORF) will help Space Station crews take some of the best photographs ever snapped from an orbiting spacecraft by eliminating glare and allowing researchers to control their cameras and other equipment from the ground. The WORF is designed to make the best possible use of the high-quality research window in the Space Station's U.S. Destiny laboratory module. Engineers at the MSFC proposed a derivative of the EXPRESS (Expedite the Processing of Experiments to the Space Station) Rack already used on the Space Station and were given the go-ahead. The EXPRESS rack can hold a wide variety of experiments and provide them with power, communications, data, cooling, fluids, and other utilities - all the things that Earth-observing experiment instruments would need. WORF will supply payloads with power, data, cooling, video downlink, and stable, standardized interfaces for mounting imaging instruments. Similar to specialized orbital observatories, the interior of the rack is sealed against light and coated with a special low-reflectant black paint, so payloads will be able to observe low-light-level subjects such as the faint glow of auroras. Cameras and remote sensing instruments in the WORF can be preprogrammed, controlled from the ground, or operated by a Station crewmember by using a flexible shroud designed to cinch tightly around the crewmember's waist. The WORF is scheduled to be launched aboard the STS-114 Space Shuttle mission in the year 2003.

Server rack for improved data center management

DOEpatents

Bermudez Rodriguez, Sergio A.; Hamann, Hendrik F.; Wehle, Hans-Dieter

2018-01-09

Methods and systems for data center management include collecting sensor data from one or more sensors in a rack; determining a location and identifying information for each asset in the rack using a set of asset tags associated with respective assets; communicating the sensor and asset location to a communication module; receiving an instruction from the communication module; and executing the received instruction to change a property of the rack.

Surveillance of a Ventilated Rack System for Corynebacterium bovis by Sampling Exhaust-Air Manifolds.

PubMed

Manuel, Christopher A; Pugazhenthi, Umarani; Leszczynski, Jori K

2016-01-01

Corynebacterium bovis causes an opportunistic infection of nude (Foxn1, nu/nu) mice, leading to nude mouse hyperkeratotic dermatitis (scaly skin disease). Enzootic in many nude mouse colonies, C. bovis spreads rapidly to naive nude mice, despite modern husbandry practices, and is very difficult to eradicate. To facilitate rapid detection in support of eradication efforts, we investigated a surveillance method based on quantitative real-time PCR (qPCR) evaluation of swabs collected from the horizontal exhaust manifold (HEM) of an IVC rack system. We first evaluated the efficacy of rack sanitation methods for removing C. bovis DNA from the HEM of racks housing endemic colonies of infected nude mice. Pressurized water used to flush the racks' air exhaust system followed by a standard rack-washer cycle was ineffective in eliminating C. bovis DNA. Only after autoclaving did all sanitized racks test negative for C. bovis DNA. We then measured the effects of stage of infection (early or established), cage density, and cage location on the rack on time-to-detection at the HEM. Stage of infection significantly affected time-to-detection, independent of cage location. Early infections required 7.3 ± 1.2 d whereas established infections required 1 ± 0 d for detection of C. bovis at the HEM. Cage density influenced the quantity of C. bovis DNA detected but not time-to-detection. The location of the cage on the rack affected the time-to-detection only during early C. bovis infections. We suggest that qPCR swabs of HEM are useful during the routine surveillance of nude mouse colonies for C. bovis infection.

Influence of Rack Design and Disease Prevalence on Detection of Rodent Pathogens in Exhaust Debris Samples from Individually Ventilated Caging Systems.

PubMed

Bauer, Beth A; Besch-Williford, Cynthia; Livingston, Robert S; Crim, Marcus J; Riley, Lela K; Myles, Matthew H

2016-11-01

Sampling of bedding debris within the exhaust systems of ventilated racks may be a mechanism for detecting murine pathogens in colony animals. This study examined the effectiveness of detecting pathogens by PCR analysis of exhaust debris samples collected from ventilated racks of 2 different rack designs, one with unfiltered air flow from within the cage to the air-exhaust pathway, and the other had a filter between the cage and the air-exhaust pathway. For 12 wk, racks were populated with either 1 or 5 cages of mice (3 mice per cage) infected with one of the following pathogens: mouse norovirus (MNV), mouse parvovirus (MPV), mouse hepatitis virus (MHV), Helicobacter spp., Pasteurella pneumotropica, pinworms, Entamoeba muris, Tritrichomonas muris, and fur mites. Pathogen shedding by infected mice was monitored throughout the study. In the filter-containing rack, PCR testing of exhaust plenums yielded negative results for all pathogens at all time points of the study. In the rack with open air flow, pathogens detected by PCR analysis of exhaust debris included MHV, Helicobacter spp., P. pneumotropica, pinworms, enteric protozoa, and fur mites; these pathogens were detected in racks housing either 1 or 5 cages of infected mice. Neither MPV nor MNV was detected in exhaust debris, even though prolonged viral shedding was confirmed. These results demonstrate that testing rack exhaust debris from racks with unfiltered air flow detected MHV, enteric bacteria and parasites, and fur mites. However, this method failed to reliably detect MNV or MPV infection of colony animals.

Influence of Rack Design and Disease Prevalence on Detection of Rodent Pathogens in Exhaust Debris Samples from Individually Ventilated Caging Systems

PubMed Central

Bauer, Beth A; Besch-Williford, Cynthia; Livingston, Robert S; Crim, Marcus J; Riley, Lela K; Myles, Matthew H

2016-01-01

Sampling of bedding debris within the exhaust systems of ventilated racks may be a mechanism for detecting murine pathogens in colony animals. This study examined the effectiveness of detecting pathogens by PCR analysis of exhaust debris samples collected from ventilated racks of 2 different rack designs, one with unfiltered air flow from within the cage to the air-exhaust pathway, and the other had a filter between the cage and the air-exhaust pathway. For 12 wk, racks were populated with either 1 or 5 cages of mice (3 mice per cage) infected with one of the following pathogens: mouse norovirus (MNV), mouse parvovirus (MPV), mouse hepatitis virus (MHV), Helicobacter spp., Pasteurella pneumotropica, pinworms, Entamoeba muris, Tritrichomonas muris, and fur mites. Pathogen shedding by infected mice was monitored throughout the study. In the filter-containing rack, PCR testing of exhaust plenums yielded negative results for all pathogens at all time points of the study. In the rack with open air flow, pathogens detected by PCR analysis of exhaust debris included MHV, Helicobacter spp., P. pneumotropica, pinworms, enteric protozoa, and fur mites; these pathogens were detected in racks housing either 1 or 5 cages of infected mice. Neither MPV nor MNV was detected in exhaust debris, even though prolonged viral shedding was confirmed. These results demonstrate that testing rack exhaust debris from racks with unfiltered air flow detected MHV, enteric bacteria and parasites, and fur mites. However, this method failed to reliably detect MNV or MPV infection of colony animals. PMID:27931317

40 CFR 65.142 - Standards.

Code of Federal Regulations, 2010 CFR

2010-07-01

... of this subpart apply to Group 2A process vents. (c) Transfer rack requirements. The owner or... route transfer rack emissions through a closed vent system to a flare shall meet the applicable... requirements referenced therein. No other provisions of this subpart apply to transfer rack emissions routed...

Walleye dermal sarcoma virus Orf B functions through receptor for activated C kinase (RACK1) and protein kinase C

DOE Office of Scientific and Technical Information (OSTI.GOV)

Daniels, Candelaria C.; Rovnak, Joel; Quackenbush, Sandra L.

2008-06-05

Walleye dermal sarcoma virus is a complex retrovirus that is associated with walleye dermal sarcomas that are seasonal in nature. Fall developing tumors contain low levels of spliced accessory gene transcripts A and B, suggesting a role for the encoded proteins, Orf A and Orf B, in oncogenesis. In explanted tumor cells the 35 kDa Orf B accessory protein is localized to the cell periphery in structures similar to focal adhesions and along actin stress fibers. Similar localization was observed in mammalian cells. The cellular protein, receptor for activated C kinase 1 (RACK1), bound Orf B in yeast two-hybrid assaysmore » and in cell culture. Sequence analysis of walleye RACK1 demonstrated high conservation to other known RACK1 sequences. RACK1 binds to activated protein kinase C (PKC). Orf B associates with PKC{alpha}, which is constitutively activated and localized at the membrane. Activated PKC promoted cell survival, proliferation, and increased cell viability in Orf B-expressing cells.« less

Receptor for Activated C-Kinase 1 (PfRACK1) is required for Plasmodium falciparum intra-erythrocytic proliferation.

PubMed

Blomqvist, Karin; DiPetrillo, Christen; Streva, Vincent A; Pine, Stewart; Dvorin, Jeffrey D

2017-01-01

Emerging resistance to current anti-malarials necessitates a more detailed understanding of the biological processes of Plasmodium falciparum proliferation, thus allowing identification of new drug targets. The well-conserved protein Receptor for Activated C-Kinase 1 (RACK1) was originally identified in mammalian cells as an anchoring protein for protein kinase C (PKC) and has since been shown to be important for cell migration, cytokinesis, transcription, epigenetics, and protein translation. The P. falciparum ortholog, PfRACK1, is expressed in blood stages of the parasite and is diffusely localized in the parasite cytoplasm. Using a destabilizing domain to allow inducible knockdown of the endogenous protein level, we evaluated the requirement for PfRACK1 during blood-stage replication. Following destabilization, the parasites demonstrate a nearly complete growth arrest at the trophozoite stage. The essential nature of PfRACK1 suggests that the protein itself or the pathways regulated by the protein are potential targets for novel anti-malarial therapeutics. Copyright © 2016 Elsevier B.V. All rights reserved.

The fabrication of plastic cages for suspension in mass air flow racks.

PubMed

Nielsen, F H; Bailey, B

1979-08-01

A cage for suspension in mass air flow racks was constructed of plastic and used to house rats. Little or no difficulty was encountered with the mass air flow rack-suspended cage system during the 4 years it was used for the study of trace elements.

Gerst installs CMS-2 in KIBO rack

NASA Image and Video Library

2014-09-09

ISS040-E-130230 (9 Sept. 2014) --- European Space Agency astronaut Alexander Gerst, Expedition 40 flight engineer, installs a microscope for the Cell Mechanosensing-2 experiment in the Kibo laboratory of the International Space Station. The Japanese experiment, which is conducted in Kibo’s Kobairo rack, seeks to identify gravity sensors in cells that may change the expression of key proteins and genes and allowing muscles to atrophy in microgravity.

Gerst installs CMS-2 in KIBO rack

NASA Image and Video Library

2014-09-09

ISS040-E-130233 (9 Sept. 2014) --- European Space Agency astronaut Alexander Gerst, Expedition 40 flight engineer, installs a microscope for the Cell Mechanosensing-2 experiment in the Kibo laboratory of the International Space Station. The Japanese experiment, which is conducted in Kibo’s Kobairo rack, seeks to identify gravity sensors in cells that may change the expression of key proteins and genes and allowing muscles to atrophy in microgravity.

Gerst installs CMS-2 in KIBO rack

NASA Image and Video Library

2014-09-09

ISS040-E-130231 (9 Sept. 2014) --- European Space Agency astronaut Alexander Gerst, Expedition 40 flight engineer, installs a microscope for the Cell Mechanosensing-2 experiment in the Kibo laboratory of the International Space Station. The Japanese experiment, which is conducted in Kibo’s Kobairo rack, seeks to identify gravity sensors in cells that may change the expression of key proteins and genes and allowing muscles to atrophy in microgravity.

Gerst installs CMS-2 in KIBO rack

NASA Image and Video Library

2014-09-09

ISS040-E-130232 (9 Sept. 2014) --- European Space Agency astronaut Alexander Gerst, Expedition 40 flight engineer, installs a microscope for the Cell Mechanosensing-2 experiment in the Kibo laboratory of the International Space Station. The Japanese experiment, which is conducted in Kibo’s Kobairo rack, seeks to identify gravity sensors in cells that may change the expression of key proteins and genes and allowing muscles to atrophy in microgravity.

40 CFR 65.84 - Operating requirements.

Code of Federal Regulations, 2010 CFR

2010-07-01

...) CONSOLIDATED FEDERAL AIR RULE Transfer Racks § 65.84 Operating requirements. (a) Closed vent systems or process piping. An owner or operator of a transfer rack shall operate it in such a manner that emissions are... per square inch). (d) Pressure relief device. The owner or operator of a transfer rack subject to the...

Nonlinear dynamics of a rack-pinion-rack device powered by the Casimir force.

PubMed

Miri, MirFaez; Nekouie, Vahid; Golestanian, Ramin

2010-01-01

Using the lateral Casimir force-a manifestation of the quantum fluctuations of the electromagnetic field between objects with corrugated surfaces-as the main force transduction mechanism, a nanomechanical device with rich dynamical behaviors is proposed. The device is made of two parallel racks that are moving in the same direction and a pinion in the middle that couples with both racks via the noncontact lateral Casimir force. The built-in frustration in the device causes it to be very sensitive and react dramatically to minute changes in the geometrical parameters and initial conditions of the system. The noncontact nature of the proposed device could help with the ubiquitous wear problem in nanoscale mechanical systems.

Surveillance of a Ventilated Rack System for Corynebacterium bovis by Sampling Exhaust-Air Manifolds

PubMed Central

Manuel, Christopher A; Pugazhenthi, Umarani; Leszczynski, Jori K

2016-01-01

Corynebacterium bovis causes an opportunistic infection of nude (Foxn1, nu/nu) mice, leading to nude mouse hyperkeratotic dermatitis (scaly skin disease). Enzootic in many nude mouse colonies, C. bovis spreads rapidly to naive nude mice, despite modern husbandry practices, and is very difficult to eradicate. To facilitate rapid detection in support of eradication efforts, we investigated a surveillance method based on quantitative real-time PCR (qPCR) evaluation of swabs collected from the horizontal exhaust manifold (HEM) of an IVC rack system. We first evaluated the efficacy of rack sanitation methods for removing C. bovis DNA from the HEM of racks housing endemic colonies of infected nude mice. Pressurized water used to flush the racks’ air exhaust system followed by a standard rack-washer cycle was ineffective in eliminating C. bovis DNA. Only after autoclaving did all sanitized racks test negative for C. bovis DNA. We then measured the effects of stage of infection (early or established), cage density, and cage location on the rack on time-to-detection at the HEM. Stage of infection significantly affected time-to-detection, independent of cage location. Early infections required 7.3 ± 1.2 d whereas established infections required 1 ± 0 d for detection of C. bovis at the HEM. Cage density influenced the quantity of C. bovis DNA detected but not time-to-detection. The location of the cage on the rack affected the time-to-detection only during early C. bovis infections. We suggest that qPCR swabs of HEM are useful during the routine surveillance of nude mouse colonies for C. bovis infection. PMID:26817981

Retrieval-travel-time model for free-fall-flow-rack automated storage and retrieval system

NASA Astrophysics Data System (ADS)

Metahri, Dhiyaeddine; Hachemi, Khalid

2018-03-01

Automated storage and retrieval systems (AS/RSs) are material handling systems that are frequently used in manufacturing and distribution centers. The modelling of the retrieval-travel time of an AS/RS (expected product delivery time) is practically important, because it allows us to evaluate and improve the system throughput. The free-fall-flow-rack AS/RS has emerged as a new technology for drug distribution. This system is a new variation of flow-rack AS/RS that uses an operator or a single machine for storage operations, and uses a combination between the free-fall movement and a transport conveyor for retrieval operations. The main contribution of this paper is to develop an analytical model of the expected retrieval-travel time for the free-fall flow-rack under a dedicated storage assignment policy. The proposed model, which is based on a continuous approach, is compared for accuracy, via simulation, with discrete model. The obtained results show that the maximum deviation between the continuous model and the simulation is less than 5%, which shows the accuracy of our model to estimate the retrieval time. The analytical model is useful to optimise the dimensions of the rack, assess the system throughput, and evaluate different storage policies.

40 CFR 65.165 - Initial Compliance Status Reports.

Code of Federal Regulations, 2010 CFR

2010-07-01

... comply with § 65.144 by routing emissions from a storage vessel or transfer rack to a process or to a... stream is connected to a fuel gas system. (3) As specified in § 65.144(c), report that the transfer rack... storage vessel or low-throughput transfer rack to a nonflare control device or halogen reduction device...

Microgravity Disturbance Predictions in the Combustion Integrated Rack

NASA Astrophysics Data System (ADS)

Just, M.; Grodsinsky, Carlos M.

2002-01-01

This paper will focus on the approach used to characterize microgravity disturbances in the Combustion Integrated Rack (CIR), currently scheduled for launch to the International Space Station (ISS) in 2005. Microgravity experiments contained within the CIR are extremely sensitive to vibratory and transient disturbances originating on-board and off-board the rack. Therefore, several techniques are implemented to isolate the critical science locations from external vibration. A combined testing and analysis approach is utilized to predict the resulting microgravity levels at the critical science location. The major topics to be addressed are: 1) CIR Vibration Isolation Approaches, 2) Disturbance Sources and Characterization, 3) Microgravity Predictive Modeling, 4) Science Microgravity Requirements, 6) Microgravity Control, and 7) On-Orbit Disturbance Measurement. The CIR is using the Passive Rack Isolation System (PaRIS) to isolate the rack from offboard rack disturbances. By utilizing this system, CIR is connected to the U.S. Lab module structure by either 13 or 14 umbilical lines and 8 spring / damper isolators. Some on-board CIR disturbers are locally isolated by grommets or wire ropes. CIR's environmental and science on board support equipment such as air circulation fans, pumps, water flow, air flow, solenoid valves, and computer hard drives cause disturbances within the rack. These disturbers along with the rack structure must be characterized to predict whether the on-orbit vibration levels during experimentation exceed the specified science microgravity vibration level requirements. Both vibratory and transient disturbance conditions are addressed. Disturbance levels/analytical inputs are obtained for each individual disturber in a "free floating" condition in the Glenn Research Center (GRC) Microgravity Emissions Lab (MEL). Flight spare hardware is tested on an Orbital Replacement Unit (ORU) basis. Based on test and analysis, maximum disturbance level allocations are developed for each ORU. The worst-case disturbances are input into an on-orbit analytical dynamic model of the rack. These models include both NASTRAN and MATLAB Simulink models , which include eigenvector and frequency inputs of the rack rigid body modes, the rack umbilical modes, and the racks' structural modes. The disturbance areas and science locations need to be modeled accurately to give valid predictions. The analytically determined microgravity vibration levels are compared to the CIR science requirements contained in the FCF Science Requirements Envelope Document (SRED). The predicted levels will be compared with the on-orbit measurements provided by the Space Acceleration Measurement System (SAMS) sensor, which is to be mounted on the CIR optics bench.

PBF (PER620) interior. System control racks, secondary control and equipment ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

PBF (PER-620) interior. System control racks, secondary control and equipment room. Date: May 2004. INEEL negative no. HD-41-6-2 - Idaho National Engineering Laboratory, SPERT-I & Power Burst Facility Area, Scoville, Butte County, ID

Norm-Optimal ILC Applied to a High-Speed Rack Feeder

NASA Astrophysics Data System (ADS)

Schindele, Dominik; Aschemann, Harald; Ritzke, Jöran

2010-09-01

Rack feeders as automated conveying systems for high bay rackings are of high practical importance. To shorten the transport times by using trajectories with increased kinematic values accompanying control measures for a reduction of the excited structural vibrations are necessary. In this contribution, the model-based design of a norm-optimal iterative learning control structure is presented. The rack feeder is modelled as an elastic multibody system. For the mathematical description of the bending deflections a Ritz ansatz is introduced. The tracking control design is performed separately for both axes using decentralised state space representations. Both the achievable performance and the resulting tracking accuracy of the proposed control concept are shown by measurement results from the experimental set-up.

Materials Science Research Rack-1 Fire Suppressant Distribution Test Report

NASA Technical Reports Server (NTRS)

Wieland, P. O.

2002-01-01

Fire suppressant distribution testing was performed on the Materials Science Research Rack-1 (MSRR-1), a furnace facility payload that will be installed in the U.S. Lab module of the International Space Station. Unlike racks that were tested previously, the MSRR-1 uses the Active Rack Isolation System (ARIS) to reduce vibration on experiments, so the effects of ARIS on fire suppressant distribution were unknown. Two tests were performed to map the distribution of CO2 fire suppressant throughout a mockup of the MSRR-1 designed to have the same component volumes and flowpath restrictions as the flight rack. For the first test, the average maximum CO2 concentration for the rack was 60 percent, achieved within 45 s of discharge initiation, meeting the requirement to reach 50 percent throughout the rack within 1 min. For the second test, one of the experiment mockups was removed to provide a worst-case configuration, and the average maximum CO2 concentration for the rack was 58 percent. Comparing the results of this testing with results from previous testing leads to several general conclusions that can be used to evaluate future racks. The MSRR-1 will meet the requirements for fire suppressant distribution. Primary factors that affect the ability to meet the CO2 distribution requirements are the free air volume in the rack and the total area and distribution of openings in the rack shell. The length of the suppressant flowpath and degree of tortuousness has little correlation with CO2 concentration. The total area of holes in the rack shell could be significantly increased. The free air volume could be significantly increased. To ensure the highest maximum CO2 concentration, the PFE nozzle should be inserted to the stop on the nozzle.

εPKC confers acute tolerance to cerebral ischemic reperfusion injury

PubMed Central

Bright, Rachel; Sun, Guo-Hua; Yenari, Midori A.; Steinberg, Gary K.; Mochly-Rosen, Daria

2008-01-01

In response to mild ischemic stress, the brain elicits endogenous survival mechanisms to protect cells against a subsequent lethal ischemic stress, referred to as ischemic tolerance. The molecular signals that mediate this protection are thought to involve the expression and activation of multiple kinases, including protein kinase C (PKC). Here we demonstrate that εPKC mediates cerebral ischemic tolerance in vivo. Systemic delivery of ψεRACK, an εPKC-selective peptide activator, confers neuroprotection against a subsequent cerebral ischemic event when delivered immediately prior to stroke. In addition, activation of εPKC by ψεRACK treatment decreases vascular tone in vivo, as demonstrated by a reduction in microvascular cerebral blood flow. Here we demonstrate the role of acute and transient εPKC in early cerebral tolerance in vivo and suggest that extra-parenchymal mechanisms, such as vasoconstriction, may contribute to the conferred protection. PMID:18586397

STS-55 German Payload Specialist Schlegel manipulates ROTEX controls in SL-D2

NASA Technical Reports Server (NTRS)

1993-01-01

STS-55 German Payload Specialist 2 Hans Schlegel, wearing goggles (eye glasses) and positioned in front of Spacelab Deutsche 2 (SL-D2) Rack 4 System Rack controls, operates Robotics Technology Experiment (ROTEX) arm. ROTEX is a robotic arm that operates within an enclosed workcell in Rack 6 (partially visible in the foreground) and uses teleoperation from both an onboard station located nearby in Rack 4 and from a station on the ground. The device uses teleprogramming and artificial intelligence to look at the design, verification and operation of advanced autonomous systems for use in future applications. Schlegel represents the German Aerospace Research Establishment (DLR). SL-D2, a German-managed payload, is aboard Columbia, Orbiter Vehicle (OV) 102, for this science research mission.

Recalculation with SEACAB of the activation by spent fuel neutrons and residual dose originated in the racks replaced at Cofrentes NPP

NASA Astrophysics Data System (ADS)

Ortego, Pedro; Rodriguez, Alain; Töre, Candan; Compadre, José Luis de Diego; Quesada, Baltasar Rodriguez; Moreno, Raul Orive

2017-09-01

In order to increase the storage capacity of the East Spent Fuel Pool at the Cofrentes NPP, located in Valencia province, Spain, the existing storage stainless steel racks were replaced by a new design of compact borated stainless steel racks allowing a 65% increase in fuel storing capacity. Calculation of the activation of the used racks was successfully performed with the use of MCNP4B code. Additionally the dose rate at contact with a row of racks in standing position and behind a wall of shielding material has been calculated using MCNP4B code as well. These results allowed a preliminary definition of the burnker required for the storage of racks. Recently the activity in the racks has been recalculated with SEACAB system which combines the mesh tally of MCNP codes with the activation code ACAB, applying the rigorous two-step method (R2S) developed at home, benchmarked with FNG irradiation experiments and usually applied in fusion calculations for ITER project.

Design Features and Capabilities of the First Materials Science Research Rack

NASA Technical Reports Server (NTRS)

Pettigrew, P. J.; Lehoczky, S. L.; Cobb, S. D.; Holloway, T.; Kitchens, L.

2003-01-01

The First Materials Science Research Rack (MSRR-1) aboard the International Space Station (ISS) will offer many unique capabilities and design features to facilitate a wide range of materials science investigations. The initial configuration of MSRR-1 will accommodate two independent Experiment Modules (EMS) and provide the capability for simultaneous on-orbit processing. The facility will provide the common subsystems and interfaces required for the operation of experiment hardware and accommodate telescience capabilities. MSRR1 will utilize an International Standard Payload Rack (ISPR) equipped with an Active Rack Isolation System (ARIS) for vibration isolation of the facility.

Fincke unstows a spare RPCM from the U.S. Lab during Expedition 9

NASA Image and Video Library

2004-06-04

ISS009-E-10551 (4 June 2004) --- Astronaut Edward M. (Mike) Fincke, Expedition 9 NASA ISS science officer and flight engineer, moves the Zero-G Storage Rack (ZSR) in the Destiny laboratory of the International Space Station (ISS) in order to retrieve the spare Remote Power Controller Module (RPCM), scheduled to replace the failed RPCM on the S0 (S-Zero) Truss. Fincke is positioned above the ZSR, which has been pulled from the Express Rack.

The placement of equipment in the Space Station Freedom using constraint based reasoning

NASA Technical Reports Server (NTRS)

Tanner, Steve; Fennel, Randy

1991-01-01

This paper describes the Rack Equipment Placement and Optimization System. The primary objective of this system is to assist engineers with the placement of equipment into the racks of the modules of Space Station Freedom. It accomplishes this by showing a user where equipment placement is possible and by generating potential layouts. The system uses an explicit representation of integration constraints to search for potential solutions for individual rack equipment items. A simulated annealing process is being evaluated for total solution generation as well. Versions of this system are in use now and are assisting with the development of the Space Station Freedom at the Marshall Space Flight Center in Huntsville, Alabama.

International Space Station (ISS)

NASA Image and Video Library

2001-03-01

The Environmental Control and Life Support System (ECLSS) Group of the Flight Projects Directorate at the Marshall Space Flight Center in Huntsville, Alabama, is responsible for designing and building the life support systems that will provide the crew of the International Space Station (ISS) a comfortable environment in which to live and work. This photograph shows the mockup of the the ECLSS to be installed in the Node 3 module of the ISS. From left to right, shower rack, waste management rack, Water Recovery System (WRS) Rack #2, WRS Rack #1, and Oxygen Generation System (OGS) rack are shown. The WRS provides clean water through the reclamation of wastewaters and is comprised of a Urine Processor Assembly (UPA) and a Water Processor Assembly (WPA). The UPA accepts and processes pretreated crewmember urine to allow it to be processed along with other wastewaters in the WPA. The WPA removes free gas, organic, and nonorganic constituents before the water goes through a series of multifiltration beds for further purification. The OGS produces oxygen for breathing air for the crew and laboratory animals, as well as for replacing oxygen loss. The OGS is comprised of a cell stack, which electrolyzes (breaks apart the hydrogen and oxygen molecules) some of the clean water provided by the WRS, and the separators that remove the gases from the water after electrolysis.

International Space Station in Orbit

NASA Technical Reports Server (NTRS)

2001-01-01

This image of the International Space Station (ISS) was photographed by one of the crewmembers of the STS-105 mission from the Shuttle Orbiter Discovery after deparating from the ISS. The STS-105 mission was the 11th ISS assembly flight and its goals were the rotation of the ISS Expedition Two crew with the Expedition Three crew, and the delivery of supplies utilizing the Italian-built Multipurpose Logistics Module (MPLM) Leonardo. Aboard Leonardo were six resupply stowage racks, four resupply stowage supply platforms, and two new scientific experiment racks, EXPRESS (Expedite the Processing of Experiments to the Space Station) Racks 4 and 5, which added science capabilities to the ISS. Another payload was the Materials International Space Station Experiment (MISSE), which included materials and other types of space exposure experiments mounted on the exterior of the ISS.

International Space Station (ISS)

NASA Image and Video Library

2001-08-20

This image of the International Space Station (ISS) was photographed by one of the crewmembers of the STS-105 mission from the Shuttle Orbiter Discovery after separating from the ISS. The STS-105 mission was the 11th ISS assembly flight and its goals were the rotation of the ISS Expedition Two crew with Expedition Three crew, and the delivery of supplies utilizing the Italian-built Multipurpose Logistic Module (MPLM) Leonardo. Aboard Leonardo were six resupply stowage racks, four resupply stowage supply platforms, and two new scientific experiment racks, EXPRESS (Expedite the Processing of Experiments to the Space Station) Racks 4 and 5, which added science capabilities to the ISS. Another payload was the Materials International Space Station Experiment (MISSE), which included materials and other types of space exposure experiments mounted on the exterior of the ISS.

Environmental Control and Life Support System Mockup

NASA Technical Reports Server (NTRS)

2001-01-01

The Environmental Control and Life Support System (ECLSS) Group of the Flight Projects Directorate at the Marshall Space Flight Center in Huntsville, Alabama, is responsible for designing and building the life support systems that will provide the crew of the International Space Station (ISS) a comfortable environment in which to live and work. This photograph shows the mockup of the the ECLSS to be installed in the Node 3 module of the ISS. From left to right, shower rack, waste management rack, Water Recovery System (WRS) Rack #2, WRS Rack #1, and Oxygen Generation System (OGS) rack are shown. The WRS provides clean water through the reclamation of wastewaters and is comprised of a Urine Processor Assembly (UPA) and a Water Processor Assembly (WPA). The UPA accepts and processes pretreated crewmember urine to allow it to be processed along with other wastewaters in the WPA. The WPA removes free gas, organic, and nonorganic constituents before the water goes through a series of multifiltration beds for further purification. The OGS produces oxygen for breathing air for the crew and laboratory animals, as well as for replacing oxygen loss. The OGS is comprised of a cell stack, which electrolyzes (breaks apart the hydrogen and oxygen molecules) some of the clean water provided by the WRS, and the separators that remove the gases from the water after electrolysis.

Innovative Ballasted Flat Roof Solar PV Racking System

DOE Office of Scientific and Technical Information (OSTI.GOV)

Peek, Richard T.

2014-12-15

The objective of this project was to reduce the cost of racking for PV solar on flat commercial rooftops. Cost reductions would come from both labor savings and material savings related to the installation process. The rack would need to accommodate the majority of modules available on the market. Cascade Engineering has a long history of converting traditional metal type applications over to plastic. Injection molding of plastics have numerous advantages including selection of resin for the application, placing the material exactly where it is needed, designing in features that will speed up the installation process, and weight reduction ofmore » the array. A plastic rack would need to meet the requirements of UL2703, Mounting systems, mounting devices, clamping/retention devices, and ground lugs for use with flat-plate photovoltaic modules and panels. Comparing original data to the end of project racking design, racking material costs were reduced 50% and labor costs reduced 64%. The racking product accommodates all 60 and 72 cell panels on the market, meets UL2703 requirements, contributes only 1.3 pounds per square foot of weight to the array, requires little ballast to secure the array, automatically grounds the module when the module is secured, stacks/nests well for shipping/fewer lifts to the roof, provides integrated wire routing, allows water to drain on the roof, and accommodates various seismic roof connections. Project goals were achieved as noted in the original funding application.« less

Quantification, Distribution, and Possible Source of Bacterial Biofilm in Mouse Automated Watering Systems

PubMed Central

Meier, Thomas R; Maute, Carrie J; Cadillac, Joan M; Lee, Ji Young; Righter, Daniel J; Hugunin, Kelly MS; Deininger, Rolf A; Dysko, Robert C

2008-01-01

The use of automated watering systems for providing drinking water to rodents has become commonplace in the research setting. Little is known regarding bacterial biofilm growth within the water piping attached to the racks (manifolds). The purposes of this project were to determine whether the mouse oral flora contributed to the aerobic bacterial component of the rack biofilm, quantify bacterial growth in rack manifolds over 6 mo, assess our rack sanitation practices, and quantify bacterial biofilm development within sections of the manifold. By using standard methods of bacterial identification, the aerobic oral flora of 8 strains and stocks of mice were determined on their arrival at our animal facility. Ten rack manifolds were sampled before, during, and after sanitation and monthly for 6 mo. Manifolds were evaluated for aerobic bacterial growth by culture on R2A and trypticase soy agar, in addition to bacterial ATP quantification by bioluminescence. In addition, 6 racks were sampled at 32 accessible sites for evaluation of biofilm distribution within the watering manifold. The identified aerobic bacteria in the oral flora were inconsistent with the bacteria from the manifold, suggesting that the mice do not contribute to the biofilm bacteria. Bacterial growth in manifolds increased while they were in service, with exponential growth of the biofilm from months 3 to 6 and a significant decrease after sanitization. Bacterial biofilm distribution was not significantly different across location quartiles of the rack manifold, but bacterial levels differed between the shelf pipe and connecting elbow pipes. PMID:18351724

Test Rack Development for Extended Operation of Advanced Stirling Convertors at NASA Glenn Research Center

NASA Technical Reports Server (NTRS)

Dugala, Gina M.

2010-01-01

The U.S. Department of Energy, Lockheed Martin Space Systems Company, Sunpower Inc., and NASA Glenn Research Center (GRC) have been developing an Advanced Stirling Radioisotope Generator (ASRG) for use as a power system on space science missions. This generator will make use of free-piston Stirling convertors to achieve higher conversion efficiency than with currently available alternatives. One part of NASA GRC's support of ASRG development includes extended operation testing of Advanced Stirling Convertors (ASCs) developed by Sunpower Inc. and GRC. The ASC consists of a free-piston Stirling engine integrated with a linear alternator. NASA GRC has been building test facilities to support extended operation of the ASCs for several years. Operation of the convertors in the test facility provides convertor performance data over an extended period of time. One part of the test facility is the test rack, which provides a means for data collection, convertor control, and safe operation. Over the years, the test rack requirements have changed. The initial ASC test rack utilized an alternating-current (AC) bus for convertor control; the ASRG Engineering Unit (EU) test rack can operate with AC bus control or with an ASC Control Unit (ACU). A new test rack is being developed to support extended operation of the ASC-E2s with higher standards of documentation, component selection, and assembly practices. This paper discusses the differences among the ASC, ASRG EU, and ASC-E2 test racks.

Quantification, distribution, and possible source of bacterial biofilm in mouse automated watering systems.

PubMed

Meier, Thomas R; Maute, Carrie J; Cadillac, Joan M; Lee, Ji Young; Righter, Daniel J; Hugunin, Kelly M S; Deininger, Rolf A; Dysko, Robert C

2008-03-01

The use of automated watering systems for providing drinking water to rodents has become commonplace in the research setting. Little is known regarding bacterial biofilm growth within the water piping attached to the racks (manifolds). The purposes of this project were to determine whether the mouse oral flora contributed to the aerobic bacterial component of the rack biofilm, quantify bacterial growth in rack manifolds over 6 mo, assess our rack sanitation practices, and quantify bacterial biofilm development within sections of the manifold. By using standard methods of bacterial identification, the aerobic oral flora of 8 strains and stocks of mice were determined on their arrival at our animal facility. Ten rack manifolds were sampled before, during, and after sanitation and monthly for 6 mo. Manifolds were evaluated for aerobic bacterial growth by culture on R2A and trypticase soy agar, in addition to bacterial ATP quantification by bioluminescence. In addition, 6 racks were sampled at 32 accessible sites for evaluation of biofilm distribution within the watering manifold. The identified aerobic bacteria in the oral flora were inconsistent with the bacteria from the manifold, suggesting that the mice do not contribute to the biofilm bacteria. Bacterial growth in manifolds increased while they were in service, with exponential growth of the biofilm from months 3 to 6 and a significant decrease after sanitization. Bacterial biofilm distribution was not significantly different across location quartiles of the rack manifold, but bacterial levels differed between the shelf pipe and connecting elbow pipes.

15. Detail of 1946 chain rack alot for moving blocks ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

15. Detail of 1946 chain rack alot for moving blocks on floor of drydock in far SE corner of South Section. In 1994 theme chain rack alots and accompanying blocking mechanisms were no longer in use and were extremely deteriorated. For view of system as originally installed, see 1946 historic copy photograph WA-116-E-33. - Puget Sound Naval Shipyard, Drydock No. 3, Farragut Avenue, Bremerton, Kitsap County, WA

Field Trial on a Rack-mounted DC Power Supply System with 80-Ah Lithium-ion Batteries

NASA Astrophysics Data System (ADS)

Matsushima, Toshio

Using an industrial lithium-ion battery that has higher energy density than conventional valve-regulated lead-acid batteries, a rack-mounted DC-power-supply system was assembled and tested at a base transceiver station (BTS) offering actual services. A nominal output voltage and maximum output current of the system is 53.5V and 20A, respectively. An 80-Ah lithium-ion battery composed of 13 cells connected in series was applied in the system and maintained in a floating charge method. The DC-power-supply system was installed in a 19-inch power rack in the telecommunications equipment box at BTS. The characteristics of the 80Ah lithium-ion battery, specifications of the DC-power-supply system and field-test results were shown in this paper.

40 CFR 65.82 - Design requirements.

Code of Federal Regulations, 2010 CFR

2010-07-01

...) CONSOLIDATED FEDERAL AIR RULE Transfer Racks § 65.82 Design requirements. (a) The owner or operator shall equip each transfer rack with either one of the following equipment: (1) A closed vent system which routes...

A "Kanes's Dynamics" Model for the Active Rack Isolation System

NASA Technical Reports Server (NTRS)

Hampton, R. David; Beech, Geoffrey

1999-01-01

Many microgravity space-science experiments require vibratory acceleration levels unachievable without active isolation. The Boeing Corporation's Active Rack Isolation System (ARIS) employs a novel combination of magnetic actuation and mechanical linkages, to address these isolation requirements on the International Space Station (ISS). ARIS provides isolation at the rack (international Standard Payload Rack, or ISPR) level. Effective model-based vibration isolation requires (1) an appropriate isolation device, (2) an adequate dynamic (i.e., mathematical) model of that isolator, and (3) a suitable, corresponding controller. ARIS provides the ISS response to the first requirement. This paper presents one response to the second, in a state-space framework intended to facilitate an optimal-controls approach to the third. The authors use "Kane's Dynamics" to develop an state-space, analytical (algebraic) set of linearized equations of motion for ARIS.

A "Kane's Dynamics" Model for the Active Rack Isolation System

NASA Technical Reports Server (NTRS)

Hampton, R. D.; Beech, G. S.; Rao, N. N. S.; Rupert, J. K.; Kim, Y. K.

2001-01-01

Many microgravity space science experiments require vibratory acceleration levels unachievable without active isolation. The Boeing Corporation's Active Rack Isolation System (ARIS) employs a novel combination of magnetic actuation and mechanical linkages to address these isolation requirements on the International Space Station (ISS). ARIS provides isolation at the rack (International Standard Payload Rack (ISPR)) level. Effective model-based vibration isolation requires: (1) an appropriate isolation device, (2) an adequate dynamic (i.e., mathematical) model of that isolator, and (3) a suitable, corresponding controller. ARIS provides the ISS response to the first requirement. This paper presents one response to the second, in a state space framework intended to facilitate an optimal-controls approach to the third. The authors use "Kane's Dynamics" to develop a state-space, analytical (algebraic) set of linearized equations of motion for ARIS.

Otezla, Warts and All, Racks Up Sales and Eyes Blockbuster Status.

PubMed

Reinke, Thomas

2017-10-01

Otezla-the generic name is apremilast-also exploited a new mechanism of action as the first inhibitor of phosphodiesterase 4 (PDE4) that results in increased expression of both anti-inflammatory proteins and reduced expression of their pro-inflammatory counterparts.

Physics of Colloids in Space--Plus (PCS+) Experiment Completed Flight Acceptance Testing

NASA Technical Reports Server (NTRS)

Doherty, Michael P.

2004-01-01

The Physics of Colloids in Space--Plus (PCS+) experiment successfully completed system-level flight acceptance testing in the fall of 2003. This testing included electromagnetic interference (EMI) testing, vibration testing, and thermal testing. PCS+, an Expedite the Process of Experiments to Space Station (EXPRESS) Rack payload will deploy a second set of colloid samples within the PCS flight hardware system that flew on the International Space Station (ISS) from April 2001 to June 2002. PCS+ is slated to return to the ISS in late 2004 or early 2005.

24. OVERVIEW OF SAR3 AREA, SHOWING SWITCH RACK, SERVICE YARD, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

24. OVERVIEW OF SAR-3 AREA, SHOWING SWITCH RACK, SERVICE YARD, WAREHOUSE, CARPENTER SHOP, AND STORAGE SHED. VIEW TO SOUTH-SOUTHEAST. PANORAMA 2/2. - Santa Ana River Hydroelectric System, Redlands, San Bernardino County, CA

Ground based ISS payload microgravity disturbance assessments.

PubMed

McNelis, Anne M; Heese, John A; Samorezov, Sergey; Moss, Larry A; Just, Marcus L

2005-01-01

In order to verify that the International Space Station (ISS) payload facility racks do not disturb the microgravity environment of neighboring facility racks and that the facility science operations are not compromised, a testing and analytical verification process must be followed. Currently no facility racks have taken this process from start to finish. The authors are participants in implementing this process for the NASA Glenn Research Center (GRC) Fluids and Combustion Facility (FCF). To address the testing part of the verification process, the Microgravity Emissions Laboratory (MEL) was developed at GRC. The MEL is a 6 degree of freedom inertial measurement system capable of characterizing inertial response forces (emissions) of components, sub-rack payloads, or rack-level payloads down to 10(-7) g's. The inertial force output data, generated from the steady state or transient operations of the test articles, are utilized in analytical simulations to predict the on-orbit vibratory environment at specific science or rack interface locations. Once the facility payload rack and disturbers are properly modeled an assessment can be made as to whether required microgravity levels are achieved. The modeling is utilized to develop microgravity predictions which lead to the development of microgravity sensitive ISS experiment operations once on-orbit. The on-orbit measurements will be verified by use of the NASA GRC Space Acceleration Measurement System (SAMS). The major topics to be addressed in this paper are: (1) Microgravity Requirements, (2) Microgravity Disturbers, (3) MEL Testing, (4) Disturbance Control, (5) Microgravity Control Process, and (6) On-Orbit Predictions and Verification. Published by Elsevier Ltd.

Trans-kingdom mimicry underlies ribosome customization by a poxvirus kinase.

PubMed

Jha, Sujata; Rollins, Madeline G; Fuchs, Gabriele; Procter, Dean J; Hall, Elizabeth A; Cozzolino, Kira; Sarnow, Peter; Savas, Jeffrey N; Walsh, Derek

2017-06-29

Ribosomes have the capacity to selectively control translation through changes in their composition that enable recognition of specific RNA elements. However, beyond differential subunit expression during development, evidence for regulated ribosome specification within individual cells has remained elusive. Here we report that a poxvirus kinase phosphorylates serine/threonine residues in the human small ribosomal subunit protein, receptor for activated C kinase (RACK1), that are not phosphorylated in uninfected cells or cells infected by other viruses. These modified residues cluster in an extended loop in RACK1, phosphorylation of which selects for translation of viral or reporter mRNAs with 5' untranslated regions that contain adenosine repeats, so-called polyA-leaders. Structural and phylogenetic analyses revealed that although RACK1 is highly conserved, this loop is variable and contains negatively charged amino acids in plants, in which these leaders act as translational enhancers. Phosphomimetics and inter-species chimaeras have shown that negative charge in the RACK1 loop dictates ribosome selectivity towards viral RNAs. By converting human RACK1 to a charged, plant-like state, poxviruses remodel host ribosomes so that adenosine repeats erroneously generated by slippage of the viral RNA polymerase confer a translational advantage. Our findings provide insight into ribosome customization through trans-kingdom mimicry and the mechanics of species-specific leader activity that underlie poxvirus polyA-leaders.

Trans-kingdom mimicry underlies ribosome customization by a poxvirus kinase

PubMed Central

Jha, Sujata; Rollins, Madeline G.; Fuchs, Gabriele; Procter, Dean J.; Hall, Elizabeth A.; Cozzolino, Kira; Sarnow, Peter; Savas, Jeffrey N.; Walsh, Derek

2017-01-01

Ribosomes have the capacity to selectively control translation through changes in their composition that enable recognition of specific RNA elements1. However, beyond differential subunit expression during development2,3, evidence for regulated ribosome specification within individual cells has remained elusive1. Here, we report that a poxvirus kinase phosphorylates serine/threonine residues in the small ribosomal subunit protein, Receptor for Activated C Kinase (RACK1) that are not phosphorylated in uninfected cells or cells infected by other viruses. These modified residues cluster in an extended loop in RACK1, phosphorylation of which selects for translation of viral or reporter mRNAs whose 5’ untranslated regions (UTRs) contain adenosine repeats, so-called polyA-leaders. Structural and phylogenetic analysis revealed that although RACK1 is highly conserved, this loop is variable and contains negatively charged amino acids in plants, where these leaders act as translational enhancers for poorly understood reasons. Phosphomimetics and inter-species chimeras demonstrated that negative charge in the RACK1 loop dictates ribosome selectivity towards viral RNAs. By converting human RACK1 to a charged, plant-like state, poxviruses remodel host ribosomes so that adenosine repeats erroneously generated by slippage of the viral RNA polymerase4 confer a translational advantage. Our findings uncover ribosome customization through a novel trans-kingdom mimicry and the mechanics of species-specific leader activity that underlie the enigmatic poxvirus polyA-leaders4. PMID:28636603

Rack Distribution Effects on MPLM Center of Mass

NASA Technical Reports Server (NTRS)

Tester, John T.

2005-01-01

This research was in support of exploring the need for more flexible "center of gravity (CG) specifications than those currently established by NASA for the Multi-Purpose Logistics Module (MPLM). The MPLM is the cargo carrier for International Space Station (ISS) missions. The MPLM provides locations for 16 standard racks, as shown in Figure 1; not all positions need to be filled in any given flight. The MPLM coordinate system (X(sub M), Y(sub M), Z(sub M)) is illustrated as well. For this project, the primary missions of interest were those which supply the ISS and remove excess materials on the return flights. These flights use a predominate number of "Resupply Stowage Racks" (RSR) and "Resupply Stowage Platforms" (RSP). In these two types of racks, various smaller items are stowed. Hence, these racks will exhibit a considerable range of mass values as well as a range as to where their individual CG are located.

Association of Mumps Virus V Protein with RACK1 Results in Dissociation of STAT-1 from the Alpha Interferon Receptor Complex

PubMed Central

Kubota, Toru; Yokosawa, Noriko; Yokota, Shin-ichi; Fujii, Nobuhiro

2002-01-01

It has been reported that mumps virus protein V or the C-terminal Cys-rich region of protein V (Vsp) is associated with blocking of the interferon (IFN) signal transduction pathway through a decrease in STAT-1 production. The intracellular target of the V protein was investigated by using a two-hybrid screening system with Vsp as bait. Full-length V protein and Vsp were able to bind to RACK1, and the interaction did not require two WD domains, WD1 and WD2, in RACK1. A significant interaction between V protein and RACK1 was also demonstrated in cells persistently infected with mumps virus (FLMT cells), and the formation of the complex was not affected by treatment with IFN. On the other hand, in uninfected cells, STAT-1 was associated with the long form of the β subunit of the alpha IFN receptor, and this association was mediated by the function of RACK1 as an adaptor protein. Immunoprecipitation and glutathione S-transferase pull-down experiments revealed that the association of RACK1 or mumps virus V protein with the IFN receptor was undetectable in mumps virus-infected cells. Furthermore, RACK1 interacted with mumps virus V protein with a higher affinity than STAT-1 did. Therefore, it is suggested that mumps virus V protein has the ability to interact strongly with RACK1 and consequently to bring about the disruption of the complex formed from STAT-1, RACK1, and the IFN receptor. PMID:12438593

Status of the Node 3 Regenerative Environmental Cpntrol& Life Support System Water Recovery & Oxygen Generation Systems

NASA Technical Reports Server (NTRS)

Carrasquillo, Robyn L.

2003-01-01

NASA s Marshall Space Flight Center is providing three racks containing regenerative water recovery and oxygen generation systems (WRS and OGS) for flight on the lnternational Space Station s (ISS) Node 3 element. The major assemblies included in these racks are the Water Processor Assembly (WPA), Urine Processor Assembly (UPA), Oxygen Generation Assembly (OGA), and the Power Supply Module (PSM) supporting the OGA. The WPA and OGA are provided by Hamilton Sundstrand Space Systems lnternational (HSSSI), while the UPA and PSM are being designed and manufactured in-house by MSFC. The assemblies are currently in the manufacturing and test phase and are to be completed and integrated into flight racks this year. This paper gives an overview of the technologies and system designs, technical challenges encountered and solved, and the current status.

3. DETAIL OF RACKS AND TEMPERATURE/HUMIDITY CONTROL SYSTEM IN CURING ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

3. DETAIL OF RACKS AND TEMPERATURE/HUMIDITY CONTROL SYSTEM IN CURING ROOM ON LEVEL 6; LOOKING SOUTHEAST; ENVIRONMENT INSIDE THE CURING ROOM WAS CONTROLLED BY NIAGARA MODEL 87007 SPRAY COOLER AND BUFFALO FORGE CENTRIFUGAL FAN IN BACKGROUND - Rath Packing Company, Cooler Building, Sycamore Street between Elm & Eighteenth Streets, Waterloo, Black Hawk County, IA

Multiple products management system with sensors array in automated storage and retrieval systems

NASA Astrophysics Data System (ADS)

Vongbunyong, Supachai; Roengritronnachai, Perawat; Kongsanit, Savanut; Chanok-owat, Chawisa; Polchankajorn, Pongsakorn

2018-01-01

Automated Storage and Retrieval Systems (AS/RS) have now been widely used in a number of industries due to its capability to automatically manage the storage of products in effective ways. One of the key features of AS/RS is that each rack is not assigned for a specific product resulting in the benefit of space utilization and logistics related issues. In this research, sensor arrays are equipped at each rack in order to enhance this feature. As a result, various products can be identified and mixed in each rack, so that the space utilization efficiency can be increased. To prove the concept, a prototype system consisting of a Cartesian robot that manages the storage and retrieval of products with 9 variations based on size and color. The concept of Cyber-Physical System and self-awareness of the system are also implemented in this concept prototype.

Fluids and Combustion Facility: Fluids Integrated Rack Modal Model Correlation

NASA Technical Reports Server (NTRS)

McNelis, Mark E.; Suarez, Vicente J.; Sullivan, Timothy L.; Otten, Kim D.; Akers, James C.

2005-01-01

The Fluids Integrated Rack (FIR) is one of two racks in the Fluids and Combustion Facility on the International Space Station. The FIR is dedicated to the scientific investigation of space system fluids management supporting NASA s Exploration of Space Initiative. The FIR hardware was modal tested and FIR finite element model updated to satisfy the International Space Station model correlation criteria. The final cross-orthogonality results between the correlated model and test mode shapes was greater than 90 percent for all primary target modes.

Video Monitoring and Analysis System for Vivarium Cage Racks | NCI Technology Transfer Center | TTC

Cancer.gov

This invention pertains to a system for continuous observation of rodents in home-cage environments with the specific aim to facilitate the quantification of activity levels and behavioral patterns for mice housed in a commercial ventilated cage rack.  The National Cancer Institute’s Radiation Biology Branch seeks partners interested in collaborative research to co-develop a video monitoring system for laboratory animals.

Data center cooling system

DOEpatents

Chainer, Timothy J; Dang, Hien P; Parida, Pritish R; Schultz, Mark D; Sharma, Arun

2015-03-17

A data center cooling system may include heat transfer equipment to cool a liquid coolant without vapor compression refrigeration, and the liquid coolant is used on a liquid cooled information technology equipment rack housed in the data center. The system may also include a controller-apparatus to regulate the liquid coolant flow to the liquid cooled information technology equipment rack through a range of liquid coolant flow values based upon information technology equipment temperature thresholds.

40 CFR 63.984 - Fuel gas systems and processes to which storage vessel, transfer rack, or equipment leak...

Code of Federal Regulations, 2014 CFR

2014-07-01

... times when regulated material emissions are routed to it. (2) The owner or operator of a transfer rack... function in that process; (ii) Transformed by chemical reaction into materials that are not regulated...

40 CFR 63.984 - Fuel gas systems and processes to which storage vessel, transfer rack, or equipment leak...

Code of Federal Regulations, 2012 CFR

2012-07-01

... times when regulated material emissions are routed to it. (2) The owner or operator of a transfer rack... function in that process; (ii) Transformed by chemical reaction into materials that are not regulated...

40 CFR Table 2 to Subpart Bbbbbb... - Applicability Criteria, Emission Limits, and Management Practices for Loading Racks

Code of Federal Regulations, 2010 CFR

2010-07-01

... the TOC vapors displaced from cargo tanks during product loading; and(b) Reduce emissions of TOC to...) Design and operate the vapor collection system to prevent any TOC vapors collected at one loading rack...

1. SAR1, SOUTHEAST AND SOUTHWEST ELEVATIONS, WITH SWITCH RACK AT ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. SAR-1, SOUTHEAST AND SOUTHWEST ELEVATIONS, WITH SWITCH RACK AT LEFT, AND SANTA ANA WELL #1 AND STONE RETAINING WALLS AT RIGHT. VIEW TO NORTH. - Santa Ana River Hydroelectric System, SAR-1 Powerhouse, Redlands, San Bernardino County, CA

40 CFR Table 5 to Subpart Ffff of... - Emission Limits and Work Practice Standards for Transfer Racks

Code of Federal Regulations, 2012 CFR

2012-07-01

... each . . . You must . . . 1. Group 1 transfer rack a. Reduce emissions of total organic HAP by ≥98... through a closed-vent system to any combination of control devices (except a flare); or b. Reduce....982(d) and the requirements referenced therein; or d. Use a vapor balancing system designed and...

40 CFR Table 5 to Subpart Ffff of... - Emission Limits and Work Practice Standards for Transfer Racks

Code of Federal Regulations, 2014 CFR

2014-07-01

... each . . . You must . . . 1. Group 1 transfer rack a. Reduce emissions of total organic HAP by ≥98... through a closed-vent system to any combination of control devices (except a flare); or b. Reduce....982(d) and the requirements referenced therein; or d. Use a vapor balancing system designed and...

40 CFR Table 5 to Subpart Ffff of... - Emission Limits and Work Practice Standards for Transfer Racks

Code of Federal Regulations, 2010 CFR

2010-07-01

... each . . . You must . . . 1. Group 1 transfer rack a. Reduce emissions of total organic HAP by ≥98... through a closed-vent system to any combination of control devices (except a flare); or b. Reduce....982(d) and the requirements referenced therein; or d. Use a vapor balancing system designed and...

Navier-Stokes Simulation of Airconditioning Facility of a Large Modem Computer Room

NASA Technical Reports Server (NTRS)

2005-01-01

NASA recently assembled one of the world's fastest operational supercomputers to meet the agency's new high performance computing needs. This large-scale system, named Columbia, consists of 20 interconnected SGI Altix 512-processor systems, for a total of 10,240 Intel Itanium-2 processors. High-fidelity CFD simulations were performed for the NASA Advanced Supercomputing (NAS) computer room at Ames Research Center. The purpose of the simulations was to assess the adequacy of the existing air handling and conditioning system and make recommendations for changes in the design of the system if needed. The simulations were performed with NASA's OVERFLOW-2 CFD code which utilizes overset structured grids. A new set of boundary conditions were developed and added to the flow solver for modeling the roomls air-conditioning and proper cooling of the equipment. Boundary condition parameters for the flow solver are based on cooler CFM (flow rate) ratings and some reasonable assumptions of flow and heat transfer data for the floor and central processing units (CPU) . The geometry modeling from blue prints and grid generation were handled by the NASA Ames software package Chimera Grid Tools (CGT). This geometric model was developed as a CGT-scripted template, which can be easily modified to accommodate any changes in shape and size of the room, locations and dimensions of the CPU racks, disk racks, coolers, power distribution units, and mass-storage system. The compute nodes are grouped in pairs of racks with an aisle in the middle. High-speed connection cables connect the racks with overhead cable trays. The cool air from the cooling units is pumped into the computer room from a sub-floor through perforated floor tiles. The CPU cooling fans draw cool air from the floor tiles, which run along the outside length of each rack, and eject warm air into the center isle between the racks. This warm air is eventually drawn into the cooling units located near the walls of the room. One major concern is that the hot air ejected to the middle isle might recirculate back into the cool rack side and cause thermal short-cycling. The simulations analyzed and addressed the following important elements of the computer room: 1) High-temperature build-up in certain regions of the room; 2) Areas of low air circulation in the room; 3) Potential short-cycling of the computer rack cooling system; 4) Effectiveness of the perforated cooling floor tiles; 5) Effect of changes in various aspects of the cooling units. Detailed flow visualization is performed to show temperature distribution, air-flow streamlines and velocities in the computer room.

Status of the International Space Station Regenerative ECLSS Water Recovery and Oxygen Generation Systems

NASA Technical Reports Server (NTRS)

Bagdigian, Robert M.; Cloud, Dale

2005-01-01

NASA is developing three racks containing regenerative water recovery and oxygen generation systems (WRS and OGS) for deployment on the International Space Station (ISS). The major assemblies included in these racks are the Water Processor Assembly (WPA), Urine Processor Assembly (UPA), Oxygen Generation Assembly (OGA), and the Power Supply Module (PSM) supporting the OGA. The WPA and OGA are provided by Hamilton Sundstrand Space Systems International (HSSSI), Inc., while the UPA and PSM are developed in- house by the Marshall Space Flight Center (MSFC). The assemblies have completed the manufacturing phase and are in various stages of testing and integration into the flight racks. This paper summarizes the status as of April 2005 and describes some of the technical challenges encountered and lessons learned over the past year.

Active Rack Isolation System Program and Technical Status

NASA Technical Reports Server (NTRS)

Bushnell, Glenn; Fialho, Ian; Allen, James; Quraishi, Naveed

2000-01-01

The Boeing Active Rack Isolation System (ARIS) is one of the means used to isolate acceleration-sensitive scientific experiments from structurally transmitted disturbances aboard the International Space Station. The presentation provides an overview of ARIS and technical issues associated with the development of the active control system. An overview of ARIS analytical models is presented along with recent isolation performance predictions made using these models. Issues associated with commanding and capturing ARIS data are discussed and possible future options based on the ARIS ISS Characterization Experiment (ICE) Payload On-orbit Processor (POP) are outlined. An overview of the ARIS-ICE experiment scheduled to fly on ISS Flight 6A is presented. The presentation concludes with a discussion of recent- developmental work that includes passive rack damping, umbilical redesigns and advanced multivariable control design methods.

40 CFR 65.143 - Closed vent systems.

Code of Federal Regulations, 2010 CFR

2010-07-01

... storage vessel, process vent, transfer rack, or equipment leaks. (1) Collection of emissions. Each closed... material from a storage vessel, transfer rack or equipment leaks. Inspection records shall be generated as... (B) Conduct annual visual inspections for visible, audible, or olfactory indications of leaks. (ii...

GLACIER Express Rack Setup

NASA Image and Video Library

2010-09-01

ISS024-E-012995 (1 Sept. 2010) --- NASA astronaut Tracy Caldwell Dyson, Expedition 24 flight engineer, works with the General Laboratory Active Cryogenic ISS Experiment Refrigerator (GLACIER) in the Destiny laboratory of the International Space Station.

Old dance with a new partner: EGF receptor as the phenobarbital receptor mediating Cyp2B expression.

PubMed

Meyer, Sharon A; Jirtle, Randy L

2013-05-07

The decades-long quest for the phenobarbital (PhB) receptor that mediates activation of Cyp2B would appear fulfilled with the discovery by Mutoh et al., who found that PhB binds with pharmacological affinity to the epidermal growth factor receptor (EGFR). This finding provides a molecular basis for the suppression of hepatocyte EGFR signaling observed with PhB treatment, as previously noted in the context of tumor promotion. Although the PhB-mediated induction of Cyp2B expression through the association of a canonical nuclear receptor with the 5'-enhancer PBREM of Cyp2B is well known, direct binding of PhB to constitutive active androstane receptor (CAR, also known as NR1I3) typical of other xenobiotic-activated nuclear receptors has eluded detection. One EGF-activated pathway affected by the PhB-EGFR interaction is the loss of tyrosine phosphorylation of the scaffold protein RACK1. Dephosphorylated RACK1 provides the mechanistic link between the binding of PhB to EGFR and its effects on CAR by facilitating the interaction of serine/threonine phosphatase PP2A with inactive phosphorylated CAR. The dephosphorylation of CAR enables its translocation to the nucleus and activation of Cyp2B expression. Because EGFR and transducers RACK1, PP2A, and other partners are highly networked in numerous cellular pathways, this newly discovered partnership will surely reveal new fundamental roles for PhB beyond the regulation of drug metabolism.

Environmental exposure effects on composite materials for commercial aircraft

NASA Technical Reports Server (NTRS)

Hoffman, Daniel J.; Bielawski, William J.

1991-01-01

A study was conducted to determine the effects of long term flight and ground exposure on three commercially available graphite-epoxy material systems: T300/5208, T300/5209, and T300/934. Sets of specimens were exposed on commercial aircraft and ground racks for 1, 2, 3, 5, and 10 years. Inflight specimen sites included both the interior and exterior of aircraft based in Hawaii, Texas, and New Zealand. Ground racks were located at NASA-Dryden and the above mentioned states. Similar specimens were exposed to controlled lab conditions for up to 2 years. After each exposure, specimens were tested for residual strength and a dryout procedure was used to measure moisture content. Both room and high temperature residual strengths were measured and expressed as a pct. of the unexposed strength. Lab exposures included the effects of time alone, moisture, time on moist specimens, weatherometer, and simulated ground-air-ground cycling. Residual strengths of the long term specimens were compared with residual strengths of the lab specimens. Strength retention depended on the exposure condition and the material system. Results showed that composite materials can be successfully used on commercial aircraft if environmental effects are considered.

Validation of a "Kane's Dynamics" Model for the Active Rack Isolation System

NASA Technical Reports Server (NTRS)

Beech, Geoffrey S.; Hampton, R. David

2000-01-01

Many microgravity space-science experiments require vibratory acceleration levels unachievable without active isolation. The Boeing Corporation's Active Rack Isolation System (ARIS) employs a novel combination of magnetic actuation and mechanical linkages, to address these isolation requirements on the International Space Station (ISS). ARIS provides isolation at the rack (international Standard Payload Rack, or ISPR) level. Effective model-based vibration isolation requires (1) an isolation device, (2) an adequate dynamic (i.e., mathematical) model of that isolator, and (3) a suitable, corresponding controller, ARIS provides the ISS response to the first requirement. In November 1999, the authors presented a response to the second ("A 'Kane's Dynamics' model for the Active Rack Isolation System", Hampton and Beech) intended to facilitate an optimal-controls approach to the third. This paper documents the validation of that high-fidelity dynamic model of ARIS. As before, this model contains the full actuator dynamics, however, the umbilical models are not included in this presentation. The validation of this dynamics model was achieved by utilizing two Commercial Off the Shelf (COTS) software tools: Deneb's ENVISION, and Online Dynamics' AUTOLEV. ENVISION is a robotics software package developed for the automotive industry that employs 3-dimensional (3-D) Computer Aided Design (CAD) models to facilitate both forward and inverse kinematics analyses. AUTOLEV is a DOS based interpreter that is designed in general to solve vector based mathematical problems and specifically to solve Dynamics problems using Kane's method.

Coleman works at the AR OGS Rack in the Node 3

NASA Image and Video Library

2011-02-08

ISS026-E-025143 (8 Feb. 2011) --- NASA astronaut Catherine (Cady) Coleman, Expedition 26 flight engineer, works at the Atmosphere Revitalization / Oxygen Generation System (AR OGS) rack in the Harmony node of the International Space Station. Coleman collected recirculation loop samples for subsequent analysis for pH value.

Coleman works at the AR OGS Rack in the Node 3

NASA Image and Video Library

2011-02-08

ISS026-E-025142 (8 Feb. 2011) --- NASA astronaut Catherine (Cady) Coleman, Expedition 26 flight engineer, works at the Atmosphere Revitalization / Oxygen Generation System (AR OGS) rack in the Harmony node of the International Space Station. Coleman collected recirculation loop samples for subsequent analysis for pH value.

Simplified planar model of a car steering system with rack and pinion and McPherson suspension

NASA Astrophysics Data System (ADS)

Knapczyk, J.; Kucybała, P.

2016-09-01

The paper presents the analysis and optimization of steering system with rack and pinion and McPherson suspension using spatial model and equivalent simplified planar model. The dimension of the steering linkage that give minimum steering error can be estimated using planar model. The steering error is defined as the difference between the actual angle made by the outer front wheel during steering manoeuvers and the calculated angle for the same wheel based on the Ackerman principle. For a given linear rack displacement, a specified steering arms angular displacements are determined while simultaneously ensuring best transmission angle characteristics (i) without and (ii) with imposing linear correlation between input and output. Numerical examples are used to illustrate the proposed method.

ISS Material Science Research Rack HWIL Interface Simulation

NASA Technical Reports Server (NTRS)

Williams, Philip J.; Ballard, Gary H.; Crumbley, Robert T. (Technical Monitor)

2002-01-01

In this paper, the first Material Science Research Rack (MSRR-1) hardware-in-the-loop (HWIL) interface simulation is described. Dynamic Concepts developed this HWIL simulation system with funding and management provided by the Flight Software group (ED14) of NASA-MSFC's Avionics Department. The HWIL system has been used both as a flight software development environment and as a software qualification tool. To fulfill these roles, the HWIL simulator accurately models the system dynamics of many MSRR-1 subsystems and emulates most of the internal interface signals. The modeled subsystems include the Experiment Modules, the Thermal Environment Control System, the Vacuum Access System, the Solid State Power Controller Module, and the Active Rack Isolation Systems. The emulated signals reside on three separate MIL-STD-1553B digital communication buses, the ISS Medium Rate Data Link, and several analog controller and sensor signals. To enhance the range of testing, it was necessary to simulate several off-nominal conditions that may occur in the interfacing subsystems.

Arabidopsis Receptor of Activated C Kinase1 Phosphorylation by WITH NO LYSINE8 KINASE

DOE PAGES

Urano, Daisuke; Czarnecki, Olaf; Wang, Xiaoping; ...

2014-12-08

Receptor of activated C kinase1 (RACK1) is a versatile scaffold protein that binds to numerous proteins to regulate diverse cellular pathways in mammals. In Arabidopsis (Arabidopsis thaliana), RACK1 has been shown to regulate plant hormone signaling, stress responses, and multiple processes of growth and development. However, little is known about the molecular mechanism underlying these regulations. In this paper, we show that an atypical serine (Ser)/threonine (Thr) protein kinase, WITH NO LYSINE8 (WNK8), phosphorylates RACK1. WNK8 physically interacted with and phosphorylated RACK1 proteins at two residues: Ser-122 and Thr-162. Genetic epistasis analysis of rack1 wnk8 double mutants indicated that RACK1more » acts downstream of WNK8 in the glucose responsiveness and flowering pathways. The phosphorylation-dead form, RACK1AS122A/T162A, but not the phosphomimetic form, RACK1AS122D/T162E, rescued the rack1a null mutant, implying that phosphorylation at Ser-122 and Thr-162 negatively regulates RACK1A function. The transcript of RACK1AS122D/T162E accumulated at similar levels as those of RACK1S122A/T162A. However, although the steady-state level of the RACK1AS122A/T162A protein was similar to wild-type RACK1A protein, the RACK1AS122D/T162E protein was nearly undetectable, suggesting that phosphorylation affects the stability of RACK1A proteins. In conclusion, these results suggest that RACK1 is phosphorylated by WNK8 and that phosphorylation negatively regulates RACK1 function by influencing its protein stability.« less

Full length view of the Spacelab module

NASA Image and Video Library

2016-08-12

STS083-312-031 (4-8 April 1997) --- Payload specialist Gregory T. Linteris (left) is seen at the Mid Deck Glove Box (MGBX), while astronaut Donald A. Thomas, mission specialist, works at the Expedite the Processing of Experiments to Space Station (EXPRESS) rack. MGBX is a facility that allows scientists the capability of doing tests on hardware and materials that are not approved to be handled in the open Spacelab. It is equipped with photographic, video and data recording capability, allowing a complete record of experiment operations. Experiments performed on STS-83 were Bubble Drop Nonlinear Dynamics and Fiber Supported Droplet Combustion. EXPRESS is designed to provide accommodations for Sub-rack payloads on Space Station. For STS-83, it held two payloads. The Physics of Hard Colloidal Spheres (PHaSE) and ASTRO-Plant Generic Bioprocessing Apparatus (ASTRO-PGBA), a facility with light and atmospheric controls which supports plant growth for commercial research.

Columbus Payloads Flow Rate Anomalies

NASA Technical Reports Server (NTRS)

Quaranta, Albino; Bufano, Gaetana; DePalo, Savino; Holt, James M.; Szigetvari, Zoltan; Palumberi, Sergio; Hinderer, S.

2011-01-01

The Columbus Active Thermal Control System (ATCS) is the main thermal bus for the pressurized racks working inside the European laboratory. One of the ATCS goals is to provide proper water flow rate to each payload (P/L) by controlling actively the pressure drop across the common plenum distribution piping. Overall flow measurement performed by the Water Pump Assembly (WPA) is the only flow rate monitor available at system level and is not part of the feedback control system. At rack activation the flow rate provided by the system is derived on ground by computing the WPA flow increase. With this approach, several anomalies were raised during these 3 years on-orbit, with the indication of low flow rate conditions on the European racks FSL, BioLab, EDR and EPM. This paper reviews the system and P/Ls calibration approach, the anomalies occurred, the engineering evaluation on the measurement approach and the accuracy improvements proposed, the on-orbit test under evaluation with NASA and finally discusses possible short and long term solutions in case of anomaly confirmation.

Graphical explanation in an expert system for Space Station Freedom rack integration

NASA Technical Reports Server (NTRS)

Craig, F. G.; Cutts, D. E.; Fennel, T. R.; Purves, B.

1990-01-01

The rationale and methodology used to incorporate graphics into explanations provided by an expert system for Space Station Freedom rack integration is examined. The rack integration task is typical of a class of constraint satisfaction problems for large programs where expertise from several areas is required. Graphically oriented approaches are used to explain the conclusions made by the system, the knowledge base content, and even at more abstract levels the control strategies employed by the system. The implemented architecture combines hypermedia and inference engine capabilities. The advantages of this architecture include: closer integration of user interface, explanation system, and knowledge base; the ability to embed links to deeper knowledge underlying the compiled knowledge used in the knowledge base; and allowing for more direct control of explanation depth and duration by the user. The graphical techniques employed range from simple statis presentation of schematics to dynamic creation of a series of pictures presented motion picture style. User models control the type, amount, and order of information presented.

Human Factors Evaluation of a Heliborne Electronic Warfare System (AN/ ALQ-151, Quick Fix)

DTIC Science & Technology

1978-08-01

clean off smudges and fingerprints and this, too, causes a problem when light reflects off the display surface. Consequently...hanging a piece of canvas between the OF operator’s rack and the counter- measures operator’s rack* Installation of a black curtain on a rod in

Rod gripper, changer, and storage system

NASA Technical Reports Server (NTRS)

Benson, Mark; Demi, Todd; Mcneill, Robert; Waldo, Keith; Afghan, Alex; Oliver, Jim

1989-01-01

A rod changer and storage design is presented for the lunar deep drill apparatus to be used in conjunction with the Skitter walking platform. The design must take into account all of the lunar environment and working conditions. Some of these are: (1) the moon has one sixth the gravity of earth; (2) temperature gradients can range from about -170 to 265 C; (3) because of the high transportation costs, the design must be as light as possible; and (4) the process must be remotely operated (from earth or satellite) and must be automated. Because of Skitter's multiple degree of freedom movement, the design will utilize Skitter's movement to locate an implement and transport it from the rack to the drill string. The implement will be gripped by a thumb and two finger device, identified through an electronic sensing device on the thumb, and transported from the rack to the footplate and back from the footplate to the rack. The major designs discussed in this report have been broken down into three major areas: (1) gripper design (linear transport mechanism); (2) indexing system; and (3) rack design.

Fluids and Combustion Facility Acoustic Emissions Controlled by Aggressive Low-Noise Design Process

NASA Technical Reports Server (NTRS)

Cooper, Beth A.; Young, Judith A.

2004-01-01

The Fluids and Combustion Facility (FCF) is a dual-rack microgravity research facility that is being developed by Northrop Grumman Information Technology (NGIT) for the International Space Station (ISS) at the NASA Glenn Research Center. As an on-orbit test bed, FCF will host a succession of experiments in fluid and combustion physics. The Fluids Integrated Rack (FIR) and the Combustion Integrated Rack (CIR) must meet ISS acoustic emission requirements (ref. 1), which support speech communication and hearing-loss-prevention goals for ISS crew. To meet these requirements, the NGIT acoustics team implemented an aggressive low-noise design effort that incorporated frequent acoustic emission testing for all internal noise sources, larger-scale systems, and fully integrated racks (ref. 2). Glenn's Acoustical Testing Laboratory (ref. 3) provided acoustical testing services (see the following photograph) as well as specialized acoustical engineering support as part of the low-noise design process (ref. 4).

Rack Insertion End Effector (RIEE) automation

NASA Technical Reports Server (NTRS)

Malladi, Narasimha

1993-01-01

NASA is developing a mechanism to manipulate and insert Racks into the Space Station Logistic modules. The mechanism consists of the following: a base with three motorized degrees of freedom, a 3 section motorized boom that goes from 15 to 44 feet in length, and a Rack Insertion End Effector (RIEE) with 5 hand wheels for precise alignment. The robotics section was tasked with the automation of the RIEE unit. In this report, for the automation of the RIEE unit, application of the Perceptics Vision System was conceptually developed to determine the position and orientation of the RIEE relative to the logistic module, and a MathCad program is written to display the needed displacements for precise alignment and final insertion of the Rack. The uniqueness of this report is that the whole report is in fact a MathCad program including text, derivations, and executable equations with example inputs and outputs.

McArthur rotates the CHeCS rack back into position after cleaning the AAA fan

NASA Image and Video Library

2005-12-01

ISS012-E-09931 (1 December 2005) --- Astronaut William S. (Bill) McArthur Jr., Expedition 12 commander and NASA space station science officer, rotates the Crew Health Care System (CHeCS) rack back into position after cleaning the Avionics Air Assembly fan in the Destiny laboratory of the International Space Station.

KSC-00pp1729

NASA Image and Video Library

2000-10-27

In the Space Station Processing Facility, the Italian-built Multi-Purpose Logistics Module “Raffaello” rests on a workstand where its weight and balance will be evaluated. Rafaello is the payload on mission STS-100, a Lab outfitting flight. Raffaello carries six system racks and two storage racks for the U.S. Lab. Launch of STS-100 is scheduled for April 19, 2001

McArthur rotates the CHeCS Rack during Expedition 12

NASA Image and Video Library

2005-12-09

ISS012-E-10806 (9 December 2005) --- Astronaut William S. (Bill) McArthur Jr., Expedition 12 commander and NASA space station science officer, rotates the Crew Health Care System (CHeCS) rack in order to access the Avionics Air Assembly (AAA) air ducts during in-flight maintenance (IFM) in the Destiny laboratory of the International Space Station.

A Simplified Model of ARIS for Optimal Controller Design

NASA Technical Reports Server (NTRS)

Beech, Geoffrey S.; Hampton, R. David; Kross, Denny (Technical Monitor)

2001-01-01

Many space-science experiments require active vibration isolation. Boeing's Active Rack Isolation System (ARIS) isolates experiments at the rack (vs. experiment or sub-experiment) level, with multi e experiments per rack. An ARIS-isolated rack typically employs eight actuators and thirteen umbilicals; the umbilicals provide services such as power, data transmission, and cooling. Hampton, et al., used "Kane's method" to develop an analytical, nonlinear, rigid-body model of ARIS that includes full actuator dynamics (inertias). This model, less the umbilicals, was first implemented for simulation by Beech and Hampton; they developed and tested their model using two commercial-off-the-shelf (COTS) software packages. Rupert, et al., added umbilical-transmitted disturbances to this nonlinear model. Because the nonlinear model, even for the untethered system, is both exceedingly complex and "encapsulated" inside these COTS tools, it is largely inaccessible to ARIS controller designers. This paper shows that ISPR rattle-space constraints and small ARIS actuator masses permit considerable model simplification, without significant loss of fidelity. First, for various loading conditions, comparisons are made between the dynamic responses of the nonlinear model (untethered) and a truth model. Then comparisons are made among nonlinear, linearized, and linearized reduced-mass models. It is concluded that these three models all capture the significant system rigid-body dynamics, with the third being preferred due to its relative simplicity.

ISS Payload Racks Automated Flow Control Calibration Method

NASA Technical Reports Server (NTRS)

Simmonds, Boris G.

2003-01-01

Payload Racks utilize MTL and/or LTL station water for cooling of payloads and avionics. Flow control range from valves of fully closed, to up to 300 Ibmhr. Instrument accuracies are as high as f 7.5 Ibm/hr for flow sensors and f 3 Ibm/hr for valve controller, for a total system accuracy of f 10.5 Ibm/hr. Improved methodology was developed, tested and proven that reduces accuracy of the commanded flows to less than f 1 Ibmhr. Uethodology could be packed in a "calibration kit" for on- orbit flow sensor checkout and recalibration, extending the rack operations before return to earth. -

FE Caldwell Dyson works with the MERLIN in the US Lab

NASA Image and Video Library

2010-07-18

ISS024-E-008590 (18 July 2010) --- NASA astronaut Tracy Caldwell Dyson, Expedition 24 flight engineer, works with the Microgravity Experiment Research Locker/Incubator (MERLIN) on Express rack 6 in the Destiny laboratory of the International Space Station.

The NASA Microgravity Fluid Physics Program: Knowledge for Use on Earth and Future Space Missions

NASA Technical Reports Server (NTRS)

Kohl, Fred J.; Singh, Bhim S.; Alexander, J. Iwan; Shaw, Nancy J.; Hill, Myron E.; Gati, Frank G.

2002-01-01

Building on over four decades of research and technology development related to the behavior of fluids in low gravity environments, the current NASA Microgravity Fluid Physics Program continues the quest for knowledge to further understand and design better fluids systems for use on earth and in space. The purpose of the Fluid Physics Program is to support the goals of NASA's Biological and Physical Research Enterprise which seeks to exploit the space environment to conduct research and to develop commercial opportunities, while building the vital knowledge base needed to enable efficient and effective systems for protecting and sustaining humans during extended space flights. There are currently five major research areas in the Microgravity Fluid Physics Program: complex fluids, multiphase flows and phase change, interfacial phenomena, biofluid mechanics, and dynamics and instabilities. Numerous investigations into these areas are being conducted in both ground-based laboratories and facilities and in the flight experiments program. Most of the future NASA-sponsored fluid physics and transport phenomena studies will be carried out on the International Space Station in the Fluids Integrated Rack, in the Microgravity Science Glovebox, in EXPRESS racks, and in other facilities provided by international partners. This paper will present an overview of the near- and long-term visions for NASA's Microgravity Fluid Physics Research Program and brief descriptions of hardware systems planned to achieve this research.

KSC-00pp1727

NASA Image and Video Library

2000-10-27

In the Space Station Processing Facility, the Italian-built Multi-Purpose Logistics Module “Raffaello” is suspended over a workstand where its weight and balance will be evaluated. Rafaello is the payload on mission STS-100, a Lab outfitting flight. Raffaello carries six system racks and two storage racks for the U.S. Lab. Launch of STS-100 is scheduled for April 19, 2001

KSC-00pp1728

NASA Image and Video Library

2000-10-27

In the Space Station Processing Facility, the Italian-built Multi-Purpose Logistics Module “Raffaello” is lowered onto a workstand where its weight and balance will be evaluated. Rafaello is the payload on mission STS-100, a Lab outfitting flight. Raffaello carries six system racks and two storage racks for the U.S. Lab. Launch of STS-100 is scheduled for April 19, 2001

21 CFR 886.1750 - Skiascopic rack.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Skiascopic rack. 886.1750 Section 886.1750 Food... DEVICES OPHTHALMIC DEVICES Diagnostic Devices § 886.1750 Skiascopic rack. (a) Identification. A skiascopic rack is a device that is a rack and a set of attached ophthalmic lenses of various dioptric strengths...

40 CFR 63.421 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Administrator and any other person. Controlled loading rack, for the purposes of § 63.420, means a loading rack... heat air pollutants to combustion temperatures. Uncontrolled loading rack means a loading rack used to load gasoline cargo tanks that is not a controlled loading rack. Vapor-tight gasoline cargo tank means...

78 FR 63166 - Certain Kitchen Appliance Shelving and Racks From the People's Republic of China: Countervailing...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-10-23

... Shelving and Racks From the People's Republic of China: Countervailing Duty Administrative Review; 2011... order on certain kitchen appliance shelving and racks (kitchen racks) from the People's Republic of.... Scope of the Order This order covers shelving and racks for refrigerators, freezers, combined...

Effects of suspension of air-conditioning on airtight-type racks.

PubMed

Kanzaki, M; Fujieda, M; Furukawa, T

2001-10-01

Although isolation racks are superior to open-type racks in terms of securing breeding conditions for laboratory animals, the contingency-proofing capability of the former has yet to be determined. Therefore, from the view of risk management, we studied the environmental change in isolation racks by forcibly suspending ventilation and air-conditioning and confirming the maximal time length for complete recovery to the original condition after restarting their operations. The isolation racks were placed in a room that was equipped with an independent air-conditioning system. When the inside condition of the racks reached 22-24 degrees C and 59-64% of relative humidity, the air-conditioning and ventilation were forcibly suspended and the subsequent temperature, relative humidity, ammonium and CO2 concentrations in the racks were measured over time. We found that after suspending the air-conditioning and ventilation, it took 40-60 min for temperature, and about 10 min for relative humidity to exceed the maximum values (temperature and relative humidity) referred to in the Showa 58 Nenban Guideline Jikken Doubutsu Shisetsu no Kenchiku oyobi Setsubi (Guidelines of buildings and facilities for experimental animals in Japan; Year 1983 edition). After 17 hr 25 min of the suspension of air-conditioning and ventilation, two rats were found dead. Then, the air-conditioning and ventilation were restarted. It took about 2 hr for temperature, and 50 min for relative humidity to regain the guideline values. The ammonium concentration stayed within the guideline value with a maximum concentration of 2 ppm in the experimental period, whereas the CO2 concentration was found to exceed 9% at the time of animal death.

Fluids and Combustion Facility: Combustion Integrated Rack Modal Model Correlation

NASA Technical Reports Server (NTRS)

McNelis, Mark E.; Suarez, Vicente J.; Sullivan, Timothy L.; Otten, Kim D.; Akers, James C.

2005-01-01

The Fluids and Combustion Facility (FCF) is a modular, multi-user, two-rack facility dedicated to combustion and fluids science in the US Laboratory Destiny on the International Space Station. FCF is a permanent facility that is capable of accommodating up to ten combustion and fluid science investigations per year. FCF research in combustion and fluid science supports NASA's Exploration of Space Initiative for on-orbit fire suppression, fire safety, and space system fluids management. The Combustion Integrated Rack (CIR) is one of two racks in the FCF. The CIR major structural elements include the International Standard Payload Rack (ISPR), Experiment Assembly (optics bench and combustion chamber), Air Thermal Control Unit (ATCU), Rack Door, and Lower Structure Assembly (Input/Output Processor and Electrical Power Control Unit). The load path through the rack structure is outlined. The CIR modal survey was conducted to validate the load path predicted by the CIR finite element model (FEM). The modal survey is done by experimentally measuring the CIR frequencies and mode shapes. The CIR model was test correlated by updating the model to represent the test mode shapes. The correlated CIR model delivery is required by NASA JSC at Launch-10.5 months. The test correlated CIR flight FEM is analytically integrated into the Shuttle for a coupled loads analysis of the launch configuration. The analysis frequency range of interest is 0-50 Hz. A coupled loads analysis is the analytical integration of the Shuttle with its cargo element, the Mini Payload Logistics Module (MPLM), in the Shuttle cargo bay. For each Shuttle launch configuration, a verification coupled loads analysis is performed to determine the loads in the cargo bay as part of the structural certification process.

A modeling of dynamic storage assignment for order picking in beverage warehousing with Drive-in Rack system

NASA Astrophysics Data System (ADS)

Hadi, M. Z.; Djatna, T.; Sugiarto

2018-04-01

This paper develops a dynamic storage assignment model to solve storage assignment problem (SAP) for beverages order picking in a drive-in rack warehousing system to determine the appropriate storage location and space for each beverage products dynamically so that the performance of the system can be improved. This study constructs a graph model to represent drive-in rack storage position then combine association rules mining, class-based storage policies and an arrangement rule algorithm to determine an appropriate storage location and arrangement of the product according to dynamic orders from customers. The performance of the proposed model is measured as rule adjacency accuracy, travel distance (for picking process) and probability a product become expiry using Last Come First Serve (LCFS) queue approach. Finally, the proposed model is implemented through computer simulation and compare the performance for different storage assignment methods as well. The result indicates that the proposed model outperforms other storage assignment methods.

Microgravity Acceleration Measurement System (MAMS) Flight Configuration Verification and Status

NASA Technical Reports Server (NTRS)

Wagar, William

2000-01-01

The Microgravity Acceleration Measurement System (MAMS) is a precision spaceflight instrument designed to measure and characterize the microgravity environment existing in the US Lab Module of the International Space Station. Both vibratory and quasi-steady triaxial acceleration data are acquired and provided to an Ethernet data link. The MAMS Double Mid-Deck Locker (DMDL) EXPRESS Rack payload meets all the ISS IDD and ICD interface requirements as discussed in the paper which also presents flight configuration illustrations. The overall MAMS sensor and data acquisition performance and verification data are presented in addition to a discussion of the Command and Data Handling features implemented via the ISS, downlink and the GRC Telescience Center displays.

76 FR 62364 - Certain Kitchen Appliance Shelving and Racks From the People's Republic of China: Preliminary...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-07

... Shelving and Racks From the People's Republic of China: Preliminary Results of the Countervailing Duty... countervailable duty order on certain kitchen appliance shelving and racks (``Kitchen Racks'') from the People's... Kitchen Appliance Shelving and Racks From the People's Republic of China: Countervailing Duty Order, 74 FR...

40 CFR 63.422 - Standards: Loading racks.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 9 2010-07-01 2010-07-01 false Standards: Loading racks. 63.422....422 Standards: Loading racks. (a) Each owner or operator of loading racks at a bulk gasoline terminal... facility” used in § 60.502 of this chapter means the loading racks that load gasoline cargo tanks at the...

Random Access Frames (RAF): Alternative to Rack and Standoff for Deep Space Habitat Outfitting

NASA Technical Reports Server (NTRS)

Howe, A. Scott; Polit-Casillas, Raul

2014-01-01

A modular Random Access Frame (RAF) system is proposed as an alternative to the International Standard Payload Rack (ISPR) for internal module layout and outfitting in a Deep Space Habitat (DSH). The ISPR approach was designed to allow for efficient interchangeability of payload and experiments for the International Space Station (ISS) when frequent resupply missions were available (particularly the now-retired Space Shuttle). Though the standard interface approach to the ISPR system allowed integration of subsystems and hardware from a variety of sources and manufacturers, the heavy rack and standoff approach may not be appropriate when resupply or swap-out capabilities are not available, such as on deep space, long-duration missions. The lightweight RAF concept can allow a more dense packing of stowage and equipment, and may be easily broken down for repurposing or reuse. Several example layouts and workstations are presented.

Prototype Aerogel Insulation for Melamine-Foam Substitute: Critical Space Station Express Rack Technology

NASA Technical Reports Server (NTRS)

Noever, David A.; Sibille, Laurent; Smith, David; Cronise, Raymond

1998-01-01

There is a current lack of environmentally acceptable foams to insulate Long-Duration Human Spaceflight Missions, including the experimental Express Rack for the Space Station. A recent 60-day manned test in a sealed chamber at Johnson Space Center (JSC) was nearly aborted, because of persistently high formaldehyde concentrations in the chamber. Subsequent investigation showed that the source was melamine foam (used extensively for acoustic insulation). The thermal and acoustic potential for melamine-foam substitutes is evaluated for scale-up to a silica-based foam and aerogel, which is environmentally benign for long duration space flight. These features will be discussed in reference to an aerogel prototype to: 1) assemble material strength data for various formulated aerogels, both silica and organic carbon aerogels; 2) assemble the aerogel into panels of mylar/vacuum-encapsulated rigid boards which can be molded in various shapes and rigidities; and 3) describe a process for space applications for formaldehyde-free, long duration thermal and acoustic insulators.

PCR Testing of a Ventilated Caging System to Detect Murine Fur Mites

PubMed Central

Jensen, Eric S; Allen, Kenneth P; Henderson, Kenneth S; Szabo, Aniko; Thulin, Joseph D

2013-01-01

Rodents housed in microisolation caging are commonly monitored for infectious agents by the use of soiled bedding sentinels. This strategy relies on the successful transmission of rodent pathogens from the index rodents via soiled bedding to sentinel cages and the subsequent infection or colonization of sentinel rodents. When the prevalence of a pathogen is low or the target agent is not readily transmitted by soiled bedding, alternative testing methodologies should be used. Given the continued prevalence of institutions self-reporting murine fur mites and with the advent of a new sensitive and specific PCR assay for mites, we sought to determine whether the exhaust system of an individual ventilated caging (IVC) system could be used for monitoring the rack's rodent population for mites rather than relying on the responses of sentinels. We deployed single cages of mice (Mus musculus) that were known to be infested with either Radfordia affinis or Myobia musculi on a 70-cage rack, sampled the horizontal exhaust manifolds weekly, and used the new PCR assay to test these samples for mite DNA. We detected the presence of fur mites at a 94.1% probability of detection within 4 wk of placement. Therefore, we recommend swabbing and testing the shelf exhaust manifolds of IVC racks rather than relying on soiled-bedding sentinels as an indicator of the mite status of the rodents on that rack. PMID:23562030

Furniture Rack Corrosion Coupon Surveillance - 2012 Update

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mickalonis, J. I.; Murphy, T. R.; Berry, C. J.

Under the L Basin corrosion surveillance program furniture rack coupons immersed for 14 years (FY2009 coupons) and 16 years (FY2011 coupons) were analyzed and the results trended with coupons exposed for shorter times. In addition, a section harvested from an actual furniture rack that was immersed for 14 years was analyzed for pitting in the weld and heat-affected-zone (HAZ) regions. The L Basin operations maintained very good water quality over the entire immersion period for these samples. These results for FY2009 and FY2011 coupons showed that the average pit depths for the 6061 and 6063 base metal are 1 andmore » 2 mils, respectively, while those for the weld and HAZ are 3 and 4 mils, respectively. The results for the weld and HAZ regions are similar to coupons removed during the period of FY2003 to FY2007. These similarities indicate that the pit development occurred quickly followed by slow kinetics of increase in pit depth. For the actual furniture rack sample average pits of 5 and 2 mils were measured for the HAZ and weld, respectively. These results demonstrate that pitting corrosion of the aluminum furniture racks used to support the spent fuel occurs in waters of good quality. The corrosion kinetics or pit depth growth rate is much less that 1 mil/year, and would not impact long-term use of this material system for fuel storage racks in L Basin if good water quality is maintained.« less

McArthur removes AAA clamps and ducts inside the CHeCS Rack during Expedition 12

NASA Image and Video Library

2005-12-09

ISS012-E-10817 (9 December 2005) --- Astronaut William S. (Bill) McArthur Jr., Expedition 12 commander and NASA space station science officer, opens the back panel of the Crew Health Care System (CHeCS) rack and removes the Avionics Air Assembly (AAA) air ducts during in-flight maintenance (IFM) in the Destiny laboratory of the International Space Station.

Water-Cooled Data Center Packs More Power Per Rack | Poster

Cancer.gov

By Frank Blanchard and Ken Michaels, Staff Writers Behind each tall, black computer rack in the data center at the Advanced Technology Research Facility (ATRF) is something both strangely familiar and oddly out of place: It looks like a radiator. The back door of each cabinet is gridded with the coils of the Liebert cooling system, which circulates chilled water to remove heat

Using of simulation for comparison of technologies for pallets storing

NASA Astrophysics Data System (ADS)

Kříž, Pavel; Chramcov, Bronislav; Jemelka, Milan

2016-06-01

The paper highlights the problem oftechnology for pallet storing. The aim is to compare selected technologies and to find efficient warehouse solution for the real company, which produces a plastic parts for automotive and needs to solve storing in the new hall. The work describes differences between two pallet storing technologies - static racking system and powered mobile racking system. Comparison contains description, advantages and disadvantages of the both systems. Real data from real project are used for the evaluation of necessary parameters. The result presents proposal of solution which can meet all initial conditions.

Direct Interaction between Scaffolding Proteins RACK1 and 14-3-3ζ Regulates Brain-derived Neurotrophic Factor (BDNF) Transcription*

PubMed Central

Neasta, Jérémie; Kiely, Patrick A.; He, Dao-Yao; Adams, David R.; O'Connor, Rosemary; Ron, Dorit

2012-01-01

RACK1 is a scaffolding protein that spatially and temporally regulates numerous signaling cascades. We previously found that activation of the cAMP signaling pathway induces the translocation of RACK1 to the nucleus. We further showed that nuclear RACK1 is required to promote the transcription of the brain-derived neurotrophic factor (BDNF). Here, we set out to elucidate the mechanism underlying cAMP-dependent RACK1 nuclear translocation and BDNF transcription. We identified the scaffolding protein 14-3-3ζ as a direct binding partner of RACK1. Moreover, we found that 14-3-3ζ was necessary for the cAMP-dependent translocation of RACK1 to the nucleus. We further observed that the disruption of RACK1/14-3-3ζ interaction with a peptide derived from the RACK1/14-3-3ζ binding site or shRNA-mediated 14-3-3ζ knockdown inhibited cAMP induction of BDNF transcription. Together, these data reveal that the function of nuclear RACK1 is mediated through its interaction with 14-3-3ζ. As RACK1 and 14-3-3ζ are two multifunctional scaffolding proteins that coordinate a wide variety of signaling events, their interaction is likely to regulate other essential cellular functions. PMID:22069327

The ISS Fluids Integrated Rack (FIR): a Summary of Capabilities

NASA Astrophysics Data System (ADS)

Gati, F.; Hill, M. E.

2002-01-01

The Fluids Integrated Rack (FIR) is a modular, multi-user scientific research facility that will fly in the U.S. laboratory module, Destiny, of the International Space Station (ISS). The FIR will be one of the two racks that will make up the Fluids and Combustion Facility (FCF) - the other being the Combustion Integrated Rack (CIR). The ISS will provide the FCF with the necessary resources, such as power and cooling. While the ISS crew will be available for experiment operations, their time will be limited. The FCF is, therefore, being designed for autonomous operations and remote control operations. Control of the FCF will be primarily through the Telescience Support Center (TSC) at the Glenn Research Center. The FCF is being designed to accommodate a wide range of combustion and fluids physics experiments within the ISS resources and constraints. The primary mission of the FIR, however, is to accommodate experiments from four major fluids physics disciplines: Complex Fluids; Multiphase Flow and Heat Transfer; Interfacial Phenomena; and Dynamics and Stability. The design of the FIR is flexible enough to accommodate experiments from other science disciplines such as Biotechnology. The FIR flexibility is a result of the large volume dedicated for experimental hardware, easily re-configurable diagnostics that allow for unique experiment configurations, and it's customizable software. The FIR will utilize six major subsystems to accommodate this broad scope of fluids physics experiments. The major subsystems are: structural, environmental, electrical, gaseous, command and data management, and imagers and illumination. Within the rack, the FIR's structural subsystem provides an optics bench type mechanical interface for the precise mounting of experimental hardware; including optical components. The back of the bench is populated with FIR avionics packages and light sources. The interior of the rack is isolated from the cabin through two rack doors that are hinged near the top and bottom of the rack. Transmission of micro-gravity disturbances to and from the rack is minimized through the Active Rack Isolation System (ARIS). The environmental subsystem will utilize air and water to remove heat generated by facility and experimental hardware. The air will be circulated throughout the rack and will be cooled by an air-water heat exchanger. Water will be used directly to cool some of the FIR components and will also be available to cool experiment hardware as required. The electrical subsystem includes the Electrical Power Control Unit (EPCU), which provides 28 VDC and 120 VDC power to the facility and the experiment hardware. The EPCU will also provide power management and control functions, as well as fault protection capabilities. The FIR will provide access to the ISS gaseous nitrogen and vacuum systems. These systems are available to support experiment operations such as the purging of experimental cells, creating flows within experimental cells and providing dry conditions where needed. The FIR Command and Data Management subsystem (CDMS) provides command and data handling for both facility and experiment hardware. The Input Output Processor (IOP) provides the overall command and data management functions for the rack including downlinking or writing data to removable drives. The IOP will also monitor the health and status of the rack subsystems. The Image Processing and Storage Units (IPSU) will perform diagnostic control and image data acquisition functions. An IPSU will be able to control a digital camera, receive image data from that camera and process/ compress image data as necessary. The Fluids Science and Avionics Package (FSAP) will provide the primary control over an experiment. The FSAP contains various computer boards/cards that will perform data and control functions. To support the imaging needs, cameras and illumination sources will be available to the investigator. Both color analog and black and white digital cameras with lenses are expected. These cameras will be capable of high resolution and, separately, frame rates up to 32,000 frames per second. Lenses for these cameras will provide both microscopic and macroscopic views. The FIR will provide two illumination sources, a 532 nm Nd:YAG laser and a white light source, both with adjustable power output. The FIR systems are being designed to maximize the amount of science that can be done on-orbit. Experiments will be designed and efficiently operated. Each individual experiment must determine the best configuration of utilizing facility capabilities and resources with augmentation of specific experiment hardware. Efficient operations will be accomplished via a combination of on-orbit physical component change-outs or processing by the crew, and software updates via ground commanding or by the crew. Careful coordination by ground and on-orbit personnel regarding the on-orbit storage and downlinking of image data will also be very important.

40 CFR 63.9075 - What definitions apply to this subpart?

Code of Federal Regulations, 2010 CFR

2010-07-01

... loading, into a tank truck, railcar, ship, or barge, of liquid HCl from a transfer (or loading) rack (as... (or loading) rack is the material that is loaded by the transfer (or loading) rack in the greatest.... Transfer (or loading) rack means the collection of loading arms and loading hoses, at a single loading rack...

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wang, Ronghai; Zhang, Ping, E-mail: zpskx001@163.com; Li, Jinhang

The hypoxia-inducible factor (HIF) is recognized as the master regulator of hypoxia response. HIF-α subunits expression are tightly regulated. In this study, our data show that ts20 cells still expressed detectable E1 protein even at 39.5° C for 12 h, and complete depletion of E1 protein expression at 39.5° C by siRNA enhanced HIF-1α and P53 protein expression. Further inhibition of E1 at 39.5 °C by siRNA, or E1 inhibitor Ube1-41 completely blocked HIF-1α degradation. Moreover, immunoprecipitations of co-transfection of HA-ubiquitin and FLAG–HIF–1α plasmids directly confirmed the involvement of ubiquitin in the hypoxic degradation of HIF-1α. Additionally, hypoxic HIF-1 α degradation is independent ofmore » HAF, RACK1, sumoylation or nuclear/cytoplasmic localization. Taken together, our data suggest that constitutive HIF-1α protein degradation in hypoxia is absolutely ubiquitination-dependent, and unidentified E3 ligase may exist for this degradation pathway. - Highlights: • HIF-1α protein is constitutively degraded in hypoxic conditions. • Requirement of ubiquitination for HIF-1α degradation in hypoxia. • Hypoxic HIF-1α degradation is independent of HAF, RACK1, sumoylation or nuclear/cytoplasmic localization.« less

Bursch and Ross by EXPRESS rack 4 in the U.S. Lab during STS-110, Expedition Four joint OPS

NASA Image and Video Library

2002-04-12

ISS004-E-10029 (12 April 2002) --- Astronauts Daniel W. Bursch (left), Expedition Four flight engineer, and Jerry L. Ross, STS-110 mission specialist, work in the Destiny laboratory on the International Space Station (ISS).

Survey of Active Vibration Isolation Systems for Microgravity Applications

NASA Technical Reports Server (NTRS)

Grodsinsky, Carlos M.; Whorton, Mark S.

2000-01-01

In view of the utility of space vehicles as orbiting science laboratories, the need for vibration isolation systems for acceleration-sensitive experiments has gained increasing visibility. To date, three active microgravity vibration isolation systems have successfully been demonstrated in flight. A tutorial discussion of the microgravity vibration isolation problem, including a description of the acceleration environment of the International Space Station and attenuation requirements, as well as a comparison or the dynamics of passive isolation, active rack-level isolation, and active payload-level isolation is provided. The flight test results of the three demonstrated systems: suppression of transient accelerations by levitation, the microgravity vibration isolation mount, and the active rack isolation system are surveyed.

Space Station and Shuttle Payloads: Rack Insertion Device Pneumatic Assembly Setup and Test

NASA Technical Reports Server (NTRS)

Conde, Nathan

2007-01-01

As part of my KSC summer internship, I was given the very cool task of writing a test preparation sheet (TPS). A TPS is a set of instructions for certain procedures or tasks, and serves as the documentation for the tasks. TPSs guide task leaders and technicians throughout the work procedures, safely, informing them of what steps will be hazardous, what precautions must be taken, and what to do in the case of an accident or emergency. I was placed in Boeing's Resupply & Return Division (R&R). R&R is responsible for sending up food and supplies to the International Space Station (ISS) with the use of three Italian Multi Purpose Logistics Modules - Leonardo, Donatello, and Raffaello. The supplies are loaded into Resupply Stowage Racks (RSRs) or Resupply Stowage Platforms (RSPs) (though, both are usually referred to as racks), depending on their size and shape. These racks are loaded into the modules with the help of a specialized crane known as the Rack Insertion Device (RID). The RID rests on four pneumatic air jacks, these allow for an operator to raise or lower the RID. The pneumatic air system supplies the air jacks with the necessary air pressure required to lift the RID.

Mice Drawer System (MDS): procedures performed on-orbit during experiment phase

NASA Astrophysics Data System (ADS)

Ciparelli, Paolo; Falcetti, Giancarlo; Tenconi, Chiara; Pignataro, Salvatore; Cotronei, Vittorio

Mice Drawer System is a payload that can be integrated inside the Space Shuttle middeck during transportation to/from the ISS, and inside the Express Rack in the ISS during experi-ment execution. It is designed to perform experiment as much automatically as possible; only maintenance activities require procedures involving crew. The first MDS experiment has been performed with Shuttle STS-128, launched in August, 28 2009 at EDT time 23:58 (06:58 Italian time). During the permanence in the Shuttle, MDS was switched on in SURVIVAL mode, cooled by air from rear part of the middeck: this mode allows to supply water and night-and-day cycles to mice in automatic mode, but not food that was supplied ad libitum before launch by a dedicated food bar inserted inside the cage. In this phase, a visual check has been performed every day by crew to verify the well-being of the mice. During the permanence in ISS, MDS was switched on in EXPERIMENT mode, cooled by water from EXPRESS RACK. In this case, MDS experiment was completely automatic: water, food, night-and-day cycles were commanded every day by the payload. Only Maintenance activities to replace consumable items and to fill the potable water reservoir were foreseen and executed by the crew. Food Envelope replacement was foreseen every 19 days, the Waste Filter replacement has been performed every 30 days. Potable Water Reservoir refilling has been performed every 9 days. Nominal activities performed on ISS were also the transfer from Shuttle to ISS and reconfiguration from ascent to on-orbit operation after launch. The reconfiguration from on-orbit to descent and transfer from ISS to Shuttle has been performed before Shuttle undock and landing.

OGS Hydrogen Sensor ORU R&R

NASA Image and Video Library

2012-04-18

ISS030-E-236919 (18 April 2012) --- NASA astronaut Dan Burbank, Expedition 30 commander, works with the Oxygen Generator System (OGS) rack in the Tranquility node of the International Space Station. Burbank unpowered the OGS, purged the hydrogen sensor Orbital Replacement Unit (ORU) with the Hydrogen Sensor ORU Purge Adapter (HOPA) for return to Earth, and replaced the hydrogen sensor with a new spare, then cleaned the rack Avionics Air Assembly (AAA).

Racking strength of walls : let-in corner bracing, sheet materials, and effect of loading rate

Treesearch

Roger L. Tuomi; David S. Gromala

1977-01-01

Determination of the racking strength of wails, which is a measure of a building system’s ability to resist wind loads, has generally been limited to performance testing. Although a standard test method exists, deviations have often been made in speed of testing and panel configuration. The purpose of this study was to determine the relative effect of some of these...

STS-98 crew checks out the U.S. Lab Destiny in Atlantis' payload bay

NASA Technical Reports Server (NTRS)

2001-01-01

KENNEDY SPACE CENTER, Fla. -- STS-98 Mission Specialist Marsha Ivins (center, pointing) checks out the U.S. Lab Destiny in the payload bay of the orbiter Atlantis. The crew is at KSC for Terminal Countdown Demonstration Test activities, which also include a simulated launch countdown. Destiny, a key element in the construction of the International Space Station, is a pressurized module designed to accommodate pressurized payloads. It has a capacity of 24 rack locations. Payload racks will occupy 13 locations especially designed to support experiments. The module already has five system racks installed inside. Launch of STS-98 on its 11-day mission is scheduled for Jan. 19 at 2:11 a.m. EST.

Phosphorylation of RACK1 in plants

DOE PAGES

Chen, Jay -Gui

2015-08-31

Receptor for Activated C Kinase 1 (RACK1) is a versatile scaffold protein that interacts with a large, diverse group of proteins to regulate various signaling cascades. RACK1 has been shown to regulate hormonal signaling, stress responses and multiple processes of growth and development in plants. However, little is known about the molecular mechanism underlying these regulations. Recently, it has been demonstrated that Arabidopsis RACK1 is phosphorylated by an atypical serine/threonine protein kinase, WITH NO LYSINE 8 (WNK8). Furthermore, RACK1 phosphorylation by WNK8 negatively regulates RACK1 function by influencing its protein stability. In conclusion, these findings promote a new regulatory systemmore » in which the action of RACK1 is controlled by phosphorylation and subsequent protein degradation.« less

Adaptor proteins in protein kinase C-mediated signal transduction.

PubMed

Schechtman, D; Mochly-Rosen, D

2001-10-01

Spatial and temporal organization of signal transduction is essential in determining the speed and precision by which signaling events occur. Adaptor proteins are key to organizing signaling enzymes near their select substrates and away from others in order to optimize precision and speed of response. Here, we describe the role of adaptor proteins in determining the specific function of individual protein kinase C (PKC) isozymes. These isozyme-selective proteins were called collectively RACKs (receptors for activated C-kinase). The role of RACKs in PKC-mediated signaling was determined using isozyme-specific inhibitors and activators of the binding of each isozyme to its respective RACK. In addition to anchoring activated PKC isozymes, RACKs anchor other signaling enzymes. RACK1, the anchoring protein for activated betaIIPKC, binds for example, Src tyrosine kinase, integrin, and phosphodiesterase. RACK2, the epsilonPKC-specific RACK, is a coated-vesicle protein and thus is involved in vesicular release and cell-cell communication. Therefore, RACKs are not only adaptors for PKC, but also serve as adaptor proteins for several other signaling enzymes. Because at least some of the proteins that bind to RACKs, including PKC itself, regulate cell growth, modulating their interactions with RACKs may help elucidate signaling pathways leading to carcinogenesis and could result in the identification of novel therapeutic targets.

Canine melanoma diagnosis: RACK1 as a potential biological marker.

PubMed

Campagne, C; Julé, S; Alleaume, C; Bernex, F; Ezagal, J; Château-Joubert, S; Estrada, M; Aubin-Houzelstein, G; Panthier, J-J; Egidy, G

2013-11-01

Melanoma diagnosis in dogs can be challenging due to the variety of histological appearances of canine melanocytic neoplasms. Markers of malignancy are needed. Receptor for activated C-kinase 1 (RACK1) was found to characterize melanomas in other mammals. We investigated the value of RACK1 detection in the classification of 19 cutaneous and 5 mucosal melanocytic neoplasms in dogs. These tumors were categorized as melanocytomas or benign and melanomas or malignant after evaluation of their morphology, mitotic index, and Ki-67 growth fraction. Using immunofluorescence, we confirmed microphthalmia-associated transcription factor (MITF) as a marker of normal and transformed melanocytic cells in dog tissues. All control (n = 10) and tumoral (n = 24) samples stained positively for MITF (34/34, 100%). Whereas RACK1 was not detected in healthy skin melanocytes, melanocytic lesions were all positive for RACK1 signal (24/24, 100%). RACK1 cytoplasmic staining appeared with 2 distinct distribution patterns: strong, diffuse, and homogeneous or granular and heterogeneous. All melanoma samples (13/13, 100%) stained homogeneously for RACK1. All melanocytomas (11/11, 100%) stained heterogeneously for RACK1. Immunohistochemistry was less consistent than immunofluorescence for all labelings in melanocytic lesions, which were often very pigmented. Thus, the fluorescent RACK1-MITF labeling pattern helped to distinguish melanomas from melanocytomas. Furthermore, RACK1 labeling correlated with 2 of 11 morphological features linked to malignancy: cell and nuclear size. These results suggest that RACK1 may be used as a marker in dog melanomas.

Arabidopsis scaffold protein RACK1A modulates rare sugar D-allose regulated gibberellin signaling.

PubMed

Fennell, Herman; Olawin, Abdulquadri; Mizanur, Rahman M; Izumori, Ken; Chen, Jin-Gui; Ullah, Hemayet

2012-11-01

As energy sources and structural components, sugars are the central regulators of plant growth and development. In addition to the abundant natural sugars in plants, more than 50 different kinds of rare sugars exist in nature, several of which show distinct roles in plant growth and development. Recently, one of the rare sugars, D-allose, an epimer of D-glucose at C3, is found to suppress plant hormone gibberellin (GA) signaling in rice. Scaffold protein RACK1A in the model plant Arabidopsis is implicated in the GA pathway as rack1a knockout mutants show insensitivity to GA in GA-induced seed germination. Using genetic knockout lines and a reporter gene, the functional role of RACK1A in the D-allose pathway was investigated. It was found that the rack1a knockout seeds showed hypersensitivity to D-allose-induced inhibition of seed germination, implicating a role for RACK1A in the D-allose mediated suppression of seed germination. On the other hand, a functional RACK1A in the background of the double knockout mutations in the other two RACK1 isoforms, rack1b/rack1c, showed significant resistance to the D-allose induced inhibition of seed germination. The collective results implicate the RACK1A in the D-allose mediated seed germination inhibition pathway. Elucidation of the rare sugar signaling mechanism will help to advance understanding of this less studied but important cellular signaling pathway.

Arabidopsis scaffold protein RACK1A modulates rare sugar D-allose regulated gibberellin signaling

PubMed Central

Fennell, Herman; Olawin, Abdulquadri; Mizanur, Rahman M.; Izumori, Ken; Chen, Jin-Gui; Ullah, Hemayet

2012-01-01

As energy sources and structural components, sugars are the central regulators of plant growth and development. In addition to the abundant natural sugars in plants, more than 50 different kinds of rare sugars exist in nature, several of which show distinct roles in plant growth and development. Recently, one of the rare sugars, D-allose, an epimer of D-glucose at C3, is found to suppress plant hormone gibberellin (GA) signaling in rice. Scaffold protein RACK1A in the model plant Arabidopsis is implicated in the GA pathway as rack1a knockout mutants show insensitivity to GA in GA-induced seed germination. Using genetic knockout lines and a reporter gene, the functional role of RACK1A in the D-allose pathway was investigated. It was found that the rack1a knockout seeds showed hypersensitivity to D-allose-induced inhibition of seed germination, implicating a role for RACK1A in the D-allose mediated suppression of seed germination. On the other hand, a functional RACK1A in the background of the double knockout mutations in the other two RACK1 isoforms, rack1b/rack1c, showed significant resistance to the D-allose induced inhibition of seed germination. The collective results implicate the RACK1A in the D-allose mediated seed germination inhibition pathway. Elucidation of the rare sugar signaling mechanism will help to advance understanding of this less studied but important cellular signaling pathway. PMID:22951405

p65 fragments, homologous to the C2 region of protein kinase C, bind to the intracellular receptors for protein kinase C.

PubMed

Mochly-Rosen, D; Miller, K G; Scheller, R H; Khaner, H; Lopez, J; Smith, B L

1992-09-08

Receptors for activated protein kinase C (RACKs) have been isolated from the particulate cell fraction of heart and brain. We previously demonstrated that binding of protein kinase C (PKC) to RACKs requires PKC activators and is via a site on PKC that is distinct from the substrate binding site. Here, we examine the possibility that the C2 region in the regulatory domain of PKC is involved in binding of PKC to RACKs. The synaptic vesicle-specific p65 protein contains two regions homologous to the C2 region of PKC. We found that three p65 fragments, containing either one or two of these PKC C2 homologous regions, bound to highly purified RACKs. Binding of the p65 fragments and PKC to RACKs was mutually exclusive; preincubation of RACKs with the p65 fragments inhibited PKC binding, and preincubation of RACKs with PKC inhibited binding of the p65 fragments. Preincubation of the p65 fragments with a peptide resembling the PKC binding site on RACKs also inhibited p65 binding to RACKs, suggesting that PKC and p65 bind to the same or nearby regions on RACKs. Since the only homologous region between PKC and the p65 fragments is the C2 region, these results suggest that the C2 region on PKC contains at least part of the RACK binding site.

The NASA Microgravity Fluid Physics Program: Research Plans for the ISS

NASA Technical Reports Server (NTRS)

Kohl, Fred J.; Singh, Bhim S.; Shaw, Nancy J.; Chiaramonte, Francis P.

2003-01-01

Building on over four decades of research and technology development related to the behavior of fluids in low gravity environments, the current NASA Microgravity Fluid Physics Program continues the quest for knowledge to further understand and design better fluids systems for use on earth and in space. NASA's Biological and Physical Research Enterprise seeks to exploit the space environment to conduct research supporting human exploration of space (strategic research), research of intrinsic scientific importance and impact (fundamental research), and commercial research. The strategic research thrust will build the vital knowledge base needed to enable NASA's mission to explore the Universe and search for life. There are currently five major research areas in the Microgravity Fluid Physics Program: complex fluids, niultiphase flows and phase change, interfacial phenomena, biofluid mechanics, and dynamics and instabilities. Numerous investigations into these areas are being conducted in both ground-based laboratories and facilities and in the flight experiments program. Most of the future NASA- sponsored flight experiments in microgravity fluid physics and transport phenomena will be carried out on the International Space Station (ISS) in the Fluids Integrated Rack (FIR), in the Microgravity Science Glovebox (MSG), in EXPRESS racks, and in other facilities provided by international partners. This paper presents an overview of the near- and long-term visions for NASA's Microgravity Fluid Physics Research Program and brief descriptions of hardware systems planned to enable this research.

MPLM Raffaello is moved for a weight and balance check in the SSPF

NASA Technical Reports Server (NTRS)

2000-01-01

In the Space Station Processing Facility, an overhead frame lifts the Italian-built Multi-Purpose Logistics Module '''Raffaello''' off its workstand. The module is being moved to a weight-and-balance workstand. Rafaello is the payload on mission STS-100, a Lab outfitting flight. Raffaello carries six system racks and two storage racks for the U.S. Lab. Launch of STS-100 is scheduled for April 19, 2001.

STS-100 MPLM Raffaello is moved to the payload canister

NASA Technical Reports Server (NTRS)

2001-01-01

KENNEDY SPACE CENTER, Fla. - Suspended by the overhead crane, the Multi-Purpose Logistics Module Raffaello approaches the end of the payload canister. Part of the payload on mission STS-100 to the International Space Station, Raffaello carries six system racks and two storage racks for the U.S. Lab. Launch of STS-100 is scheduled for April 19, 2001 at 2:41 p.m. EDT from Launch Pad 39A.

Water-Cooled Data Center Packs More Power Per Rack | Poster

Cancer.gov

By Frank Blanchard and Ken Michaels, Staff Writers Behind each tall, black computer rack in the data center at the Advanced Technology Research Facility (ATRF) is something both strangely familiar and oddly out of place: It looks like a radiator. The back door of each cabinet is gridded with the coils of the Liebert cooling system, which circulates chilled water to remove heat generated by the high-speed, high-capacity, fault-tolerant equipment.

Control Strategies for Zebra Mussel Infestations at Public Facilities

DTIC Science & Technology

1992-07-01

detailed examina- tion of hard -to-reach surfaces or specific components (such as fire protection systems or intake pipes for sensor devices) should...trash racks. Trash racks could become partially clogged with zebra mussels, shells , and other debris. Flow through the openings would be reduced, and... shells to the top of the lock wall. These are now used by Ontario Hydro for removing zebra mussels. At most facilities, the culvert is totally dewatered

40 CFR 63.982 - Requirements.

Code of Federal Regulations, 2010 CFR

2010-07-01

..., transfer racks, and equipment leaks. An owner or operator who is referred to this subpart for controlling regulated material emissions from storage vessels, process vents, low and high throughput transfer racks, or... racks. (i) For low throughput transfer racks, the owner or operator shall comply with the applicable...

The Fluids and Combustion Facility

NASA Technical Reports Server (NTRS)

Kundu, Sampa

2004-01-01

Microgravity is an environment with very weak gravitational effects. The Fluids and Combustion Facility (FCF) on the International Space Station (ISS) will support the study of fluid physics and combustion science in a long-duration microgravity environment. The Fluid Combustion Facility's design will permit both independent and remote control operations from the Telescience Support Center. The crew of the International Space Station will continue to insert and remove the experiment module, store and reload removable data storage and media data tapes, and reconfigure diagnostics on either side of the optics benches. Upon completion of the Fluids Combustion Facility, about ten experiments will be conducted within a ten-year period. Several different areas of fluid physics will be studied in the Fluids Combustion Facility. These areas include complex fluids, interfacial phenomena, dynamics and instabilities, and multiphase flows and phase change. Recently, emphasis has been placed in areas that relate directly to NASA missions including life support, power, propulsion, and thermal control systems. By 2006 or 2007, a Fluids Integrated Rack (FIR) and a Combustion Integrated Rack (CIR) will be installed inside the International Space Station. The Fluids Integrated Rack will contain all the hardware and software necessary to perform experiments in fluid physics. A wide range of experiments that meet the requirements of the international space station, including research from other specialties, will be considered. Experiments will be contained in subsystems such as the international standard payload rack, the active rack isolation system, the optics bench, environmental subsystem, electrical power control unit, the gas interface subsystem, and the command and data management subsystem. In conclusion, the Fluids and Combustion Facility will allow researchers to study fluid physics and combustion science in a long-duration microgravity environment. Additional information is included in the original extended abstract.

Fuel consumption impacts of auto roof racks

DOE PAGES

Chen, Yuche; Meier, Alan

2016-03-23

The after-market roof rack is one of the most common components attached to a vehicle for carrying over-sized items, such as bicycles and skis. It is important to understand these racks' fuel consumption impacts on both individual vehicles and the national fleet because they are widely used. We estimate the national fuel consumption impacts of roof racks using a bottom-up approach. Our model incorporates real-world data and vehicle stock information to enable assessing fuel consumption impacts for several categories of vehicles, rack configurations, and usage conditions. In addition, the model draws on two new data-gathering techniques, on-line forums and crowd-sourcing.more » The results show that nationwide, roof racks are responsible for 0.8‰ of light duty vehicle fuel consumption in 2015, corresponding to 100 million gallons of gasoline per year. Sensitivity analyses show that results are most sensitive to the fraction of vehicles with installed roof racks but carrying no equipment. Here, the aerodynamic efficiency of typical roof racks can be greatly improved and reduce individual vehicle fuel consumption; however, government policies to minimize extensive driving with empty racks--if successful--could save more fuel nationally.« less

A Survey of Active Vibration Isolation Systems for Microgravity Applications

NASA Technical Reports Server (NTRS)

Grodsinsky, Carlos M.; Whorton, Mark S.

2000-01-01

In view of the utility of space vehicles as orbiting science laboratories, the need for vibration isolation systems for acceleration sensitive experiments has gained increasing visibility. To date, three active microgravity vibration isolation systems have successfully been demonstrated in flight. This paper provides a tutorial discussion of the microgravity vibration isolation problem including a description of the acceleration environment of the International Space Station and attenuation requirements as well as a comparison of the dynamics of passive isolation, active rack-level isolation, and active payload-level isolation. This paper also surveys the flight test results of the three demonstrated systems: Suppression of Transient Accelerations By Levitation (STABLE); the Microgravity Vibration Isolation Mount (MIM); and the Active Rack Isolation System (ARIS).

Combustion Integration Rack (CIR) Testing

NASA Image and Video Library

2015-02-18

Fluids and Combustion Facility (FCF), Combustion Integration Rack (CIR) during testing in the Structural Dynamics Laboratory (SDL). The Fluids and Combustion Facility (FCF) is a set of two International Space Station (ISS) research facilities designed to support physical and biological experiments in support of technology development and validation in space. The FCF consists of two modular, reconfigurable racks called the Combustion Integration Rack (CIR) and the Fluids Integration Rack (FIR). The CIR and FIR were developed at NASAʼs Glenn Research Center.

International Standard Payload Rack volume

NASA Technical Reports Server (NTRS)

2001-01-01

Outer dimensions of the International Standard Payload Rack (ISPR) that will be used on the International Space Station (ISS) sets the envelope for scientists designing hardware for experiments in biological and physical sciences aboard ISS. The ISPR includes attachments to ISS utilities (electrical power, heating and cooling, data, fluids, vacuum, etc.) through standoffs that hold the racks in place in the lab modules. Usage will range from facilities that take entire racks to specialized drawers occupying a portion of a rack.

Interaction of “readthrough” acetylcholinesterase with RACK1 and PKCβII correlates with intensified fear-induced conflict behavior

PubMed Central

Birikh, Klara R.; Sklan, Ella H.; Shoham, Shai; Soreq, Hermona

2003-01-01

Behavioral reactions to stress are altered in numerous psychiatric and neurodegenerative syndromes, but the corresponding molecular processes and signal transduction pathways are yet unknown. Here, we report that, in mice, the stress-induced splice variant of acetylcholinesterase, AChE-R, interacts intraneuronally with the scaffold protein RACK1 and through it, with its target, protein kinase CβII (PKCβII), which is known to be involved in fear conditioning. In stress-responsive brain regions of normal FVB/N mice, the mild stress of i.p. injection increased AChE and PKCβII levels in a manner suppressible by antisense prevention of AChE-R accumulation. Injection stress also prolonged conflict between escape and hiding in the emergence into an open field test. Moreover, transgenic FVB/N mice overexpressing AChE-R displayed prolonged delay to emerge into another field (fear-induced behavioral inhibition), associated with chronically intensified neuronal colabeling of RACK1 and PKCβII in stress-responsive brain regions. These findings are consistent with the hypothesis that stress-associated changes in cholinergic gene expression regulate neuronal PKCβII functioning, promoting fear-induced conflict behavior after stress. PMID:12509514

A "Kane's Dynamics" Model for the Active Rack Isolation System

NASA Astrophysics Data System (ADS)

Rupert, J. K.; Hampton, R. D.; Beech, G. S.

2005-02-01

In the late 1980s, microgravity researchers began to voice their concern that umbilical-transmitted energy could significantly degrade the acceleration environment of microgravity space science experiments onboard manned spacecraft. Since umbilicals are necessary for many experiments, control designers began to seek ways to compensate for these "indirect" disturbances. Hampton, et al., used the Kane s method to develop a model of the active rack isolation system (ARIS) that includes (1) actuator control forces, (2) direct disturbance forces, and (3) indirect, actuator-transmitted disturbances. Their model does not, however, include the indirect, umbilical-transmitted disturbances. Since the umbilical stiffnesses are not negligible, these indirect disturbances must be included in the model. Until the umbilicals have been appropriately included, the model will be incomplete. This Technical Memorandum presents a nonlinear model of ARIS with umbilicals included. Model verification was achieved by utilizing two commercial-off-the-shelf software tools. Various forces and moments were applied to the model to yield simulated responses of the system. Plots of the simulation results show how various critical points on an ARIS-outfitted international standard payload rack behave under the application of direct disturbances, indirect disturbances, and control forces. Simulations also show system response to a variety of initial conditions.

U.S. Materials Science on the International Space Station: Status and Plans

NASA Technical Reports Server (NTRS)

Chiaramonte, Francis P.; Kelton, Kenneth F.; Matson, Douglas M.; Poirier, David R.; Trivedi, Rohit K.; Su, Ching-Hua; Volz, Martin P.; Voorhees, Peter W.

2010-01-01

This viewgraph presentation reviews the current status and NASA plans for materials science on the International Space Station. The contents include: 1) Investigations Launched in 2009; 2) DECLIC in an EXPRESS rack; 3) Dynamical Selection of Three-Dimensional Interface Patterns in Directional Solidification (DSIP); 4) Materials Science Research Rack (MSRR); 5) Materials Science Laboratory; 6) Comparison of Structure and Segregation in Alloys Directionally Solidified in Terrestrial and Microgravity Environments (MICAST/CETSOL); 7) Coarsening in Solid Liquid Mixtures 2 Reflight (CSLM 2R); 8) Crystal Growth Investigations; 9) Levitator Investigations; 10) Quasi Crystalline Undercooled Alloys for Space Investigation (QUASI); 11) The Role of Convection and Growth Competition in Phase Selection in Microgravity (LODESTARS); 12) Planned Additional Investigations; 13) SETA; 14) METCOMP; and 15) Materials Science NRA.

Patterns of structural dynamics in RACK1 protein retained throughout evolution: A hydrogen-deuterium exchange study of three orthologs

PubMed Central

Tarnowski, Krzysztof; Fituch, Kinga; Szczepanowski, Roman H; Dadlez, Michal; Kaus-Drobek, Magdalena

2014-01-01

RACK1 is a member of the WD repeat family of proteins and is involved in multiple fundamental cellular processes. An intriguing feature of RACK1 is its ability to interact with at least 80 different protein partners. Thus, the structural features enabling such interactomic flexibility are of great interest. Several previous studies of the crystal structures of RACK1 orthologs described its detailed architecture and confirmed predictions that RACK1 adopts a seven-bladed β-propeller fold. However, this did not explain its ability to bind to multiple partners. We performed hydrogen-deuterium (H-D) exchange mass spectrometry on three orthologs of RACK1 (human, yeast, and plant) to obtain insights into the dynamic properties of RACK1 in solution. All three variants retained similar patterns of deuterium uptake, with some pronounced differences that can be attributed to RACK1's divergent biological functions. In all cases, the most rigid structural elements were confined to B-C turns and, to some extent, strands B and C, while the remaining regions retained much flexibility. We also compared the average rate constants for H-D exchange in different regions of RACK1 and found that amide protons in some regions exchanged at least 1000-fold faster than in others. We conclude that its evolutionarily retained structural architecture might have allowed RACK1 to accommodate multiple molecular partners. This was exemplified by our additional analysis of yeast RACK1 dimer, which showed stabilization, as well as destabilization, of several interface regions upon dimer formation. PMID:24591271

The Dictyostelium discoideum RACK1 orthologue has roles in growth and development

PubMed Central

2014-01-01

Background The receptor for activated C-kinase 1 (RACK1) is a conserved protein belonging to the WD40 repeat family of proteins. It folds into a beta propeller with seven blades which allow interactions with many proteins. Thus it can serve as a scaffolding protein and have roles in several cellular processes. Results We identified the product of the Dictyostelium discoideum gpbB gene as the Dictyostelium RACK1 homolog. The protein is mainly cytosolic but can also associate with cellular membranes. DdRACK1 binds to phosphoinositides (PIPs) in protein-lipid overlay and liposome-binding assays. The basis of this activity resides in a basic region located in the extended loop between blades 6 and 7 as revealed by mutational analysis. Similar to RACK1 proteins from other organisms DdRACK1 interacts with G protein subunits alpha, beta and gamma as shown by yeast two-hybrid, pulldown, and immunoprecipitation assays. Unlike the Saccharomyces cerevisiae and Cryptococcus neoformans RACK1 proteins it does not appear to take over Gβ function in D. discoideum as developmental and other defects were not rescued in Gβ null mutants overexpressing GFP-DdRACK1. Overexpression of GFP-tagged DdRACK1 and a mutant version (DdRACK1mut) which carried a charge-reversal mutation in the basic region in wild type cells led to changes during growth and development. Conclusion DdRACK1 interacts with heterotrimeric G proteins and can through these interactions impact on processes specifically regulated by these proteins. PMID:24930026

MPLM during Expedition 18 / STS-126

NASA Image and Video Library

2008-11-19

S126-E-008120 (18 Nov. 2008) --- Interior view of the Leonardo Multi-Purpose Logistics Module attached to the Earth-facing port of the International Space Station's Harmony node. Leonardo was moved from Space Shuttle Endeavour's cargo bay and linked to the station on Nov. 17, carrying two water recovery systems racks for recycling urine into potable water, a second toilet system, new gallery components, two new food warmers, a food refrigerator, an experiment freezer, combustion science experiment rack, two separate sleeping quarters and a resistance exercise device (aRED) that allows station crewmembers to perform a variety of exercises.

MPLM during Expedition 18 / STS-126

NASA Image and Video Library

2008-11-19

S126-E-008117 (18 Nov. 2008) --- Interior view of the Leonardo Multi-Purpose Logistics Module attached to the Earth-facing port of the International Space Station's Harmony node. Leonardo was moved from Space Shuttle Endeavour's cargo bay and linked to the station on Nov. 17, carrying two water recovery systems racks for recycling urine into potable water, a second toilet system, new gallery components, two new food warmers, a food refrigerator, an experiment freezer, combustion science experiment rack, two separate sleeping quarters and a resistance exercise device (aRED) that allows station crewmembers to perform a variety of exercises.

MPLM during Expedition 18 / STS-126

NASA Image and Video Library

2008-11-19

S126-E-008118 (18 Nov. 2008) --- Interior view of the Leonardo Multi-Purpose Logistics Module attached to the Earth-facing port of the International Space Station's Harmony node. Leonardo was moved from Space Shuttle Endeavour's cargo bay and linked to the station on Nov. 17, carrying two water recovery systems racks for recycling urine into potable water, a second toilet system, new gallery components, two new food warmers, a food refrigerator, an experiment freezer, combustion science experiment rack, two separate sleeping quarters and a resistance exercise device (aRED) that allows station crewmembers to perform a variety of exercises.

21 CFR 882.4215 - Clip rack.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 21 Food and Drugs 8 2011-04-01 2011-04-01 false Clip rack. 882.4215 Section 882.4215 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES NEUROLOGICAL DEVICES Neurological Surgical Devices § 882.4215 Clip rack. (a) Identification. A clip rack is a...

40. Upper level, electronic racks, left to rightstatus command message ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

40. Upper level, electronic racks, left to right--status command message processing group, UHF radio, impss rack security, power supply group rack - Ellsworth Air Force Base, Delta Flight, Launch Facility, On County Road T512, south of Exit 116 off I-90, Interior, Jackson County, SD

78 FR 54450 - Certain Kitchen Appliance Shelving and Racks From the People's Republic of China: Preliminary...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-09-04

... Shelving and Racks From the People's Republic of China: Preliminary Results of Antidumping Duty... the antidumping duty order on certain kitchen appliance shelving and racks from the People's Republic...\\ is certain kitchen appliance shelving and racks. The subject merchandise is currently classifiable...

21 CFR 882.4215 - Clip rack.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Clip rack. 882.4215 Section 882.4215 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES NEUROLOGICAL DEVICES Neurological Surgical Devices § 882.4215 Clip rack. (a) Identification. A clip rack is a...

30 CFR 56.7050 - Tool and drill steel racks.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 30 Mineral Resources 1 2011-07-01 2011-07-01 false Tool and drill steel racks. 56.7050 Section 56... Jet Piercing Drilling § 56.7050 Tool and drill steel racks. Receptacles or racks shall be provided for drill steel and tools stored or carried on drills. ...

30 CFR 56.7050 - Tool and drill steel racks.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 30 Mineral Resources 1 2014-07-01 2014-07-01 false Tool and drill steel racks. 56.7050 Section 56... Jet Piercing Drilling § 56.7050 Tool and drill steel racks. Receptacles or racks shall be provided for drill steel and tools stored or carried on drills. ...

30 CFR 56.7050 - Tool and drill steel racks.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 30 Mineral Resources 1 2012-07-01 2012-07-01 false Tool and drill steel racks. 56.7050 Section 56... Jet Piercing Drilling § 56.7050 Tool and drill steel racks. Receptacles or racks shall be provided for drill steel and tools stored or carried on drills. ...

30 CFR 56.7050 - Tool and drill steel racks.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 30 Mineral Resources 1 2013-07-01 2013-07-01 false Tool and drill steel racks. 56.7050 Section 56... Jet Piercing Drilling § 56.7050 Tool and drill steel racks. Receptacles or racks shall be provided for drill steel and tools stored or carried on drills. ...

STS-98 crew checks out the U.S. Lab Destiny in Atlantis' payload bay

NASA Technical Reports Server (NTRS)

2001-01-01

KENNEDY SPACE CENTER, Fla. -- In the payload bay of the orbiter Atlantis, STS-98 Mission Specialist Robert Curbeam works with equipment he will use in space to attach the U.S. Lab Destiny to the International Space Station. The crew is at KSC for Terminal Countdown Demonstration Test activities, which also include a simulated launch countdown. A key element in the construction of the International Space Station, Destiny is a pressurized module designed to accommodate pressurized payloads. It has a capacity of 24 rack locations. Payload racks will occupy 13 locations especially designed to support experiments. The module already has five system racks installed inside. Launch of STS-98 on its 11-day mission is scheduled for Jan. 19 at 2:11 a.m. EST.

STS-98 crew checks out the U.S. Lab Destiny in Atlantis' payload bay

NASA Technical Reports Server (NTRS)

2001-01-01

KENNEDY SPACE CENTER, Fla. -- In the payload bay of the orbiter Atlantis, STS-98 Commander Ken Cockrell (center) and Mission Specialist Marsha Ivins (right) look over the mission payload, the U.S. Lab Destiny (in the background). The crew is at KSC for Terminal Countdown Demonstration Test activities, which also include a simulated launch countdown. A key element in the construction of the International Space Station, Destiny is a pressurized module designed to accommodate pressurized payloads. It has a capacity of 24 rack locations. Payload racks will occupy 13 locations especially designed to support experiments. The module already has five system racks installed inside. Launch of STS-98 on its 11-day mission is scheduled for Jan. 19 at 2:11 a.m. EST.

STS-98 crew checks out the U.S. Lab Destiny in Atlantis' payload bay

NASA Technical Reports Server (NTRS)

2001-01-01

KENNEDY SPACE CENTER, Fla. -- In the payload bay of the orbiter Atlantis, STS-98 Mission Specialists Thomas Jones (left) and Robert Curbeam (right) talk about their mission, attaching the U.S. Lab Destiny (in the background) to the International Space Station. The crew is at KSC for Terminal Countdown Demonstration Test activities, which also include a simulated launch countdown. A key element in the construction of the International Space Station, Destiny is a pressurized module designed to accommodate pressurized payloads. It has a capacity of 24 rack locations. Payload racks will occupy 13 locations especially designed to support experiments. The module already has five system racks installed inside. Launch of STS-98 on its 11-day mission is scheduled for Jan. 19 at 2:11 a.m. EST.

STS-98 crew checks out the U.S. Lab Destiny in Atlantis' payload bay

NASA Technical Reports Server (NTRS)

2001-01-01

KENNEDY SPACE CENTER, Fla. -- In the payload bay of Atlantis, two workers (background and right) watch STS-98 Robert Curbeam practice work he will do on the U.S. Lab Destiny in space. The mission payload, Destiny is a key element in the construction of the International Space Station. The lab is a pressurized module designed to accommodate pressurized payloads. It has a capacity of 24 rack locations. Payload racks will occupy 13 locations especially designed to support experiments. The module already has five system racks installed inside. The STS-98 crew is at KSC for Terminal Countdown Demonstration Test activities, which also include a simulated launch countdown. Launch of STS-98 on its 11-day mission is scheduled for Jan. 19 at 2:11 a.m. EST.

NLC Electrical

Science.gov Websites

Racks and Cable Plant Instrumentation Systems Tunnel Electronics Enclosures Low Level RF Beam Positron Electronics Vacuum Electronics (Summary) System Notes NLC Electrical System Work Package Task Descriptions

Design and Testing of a Breadboard Electrical Power Control Unit for the Fluid Combustion Facility Experiment

NASA Technical Reports Server (NTRS)

Kimnach, Greg L.; Lebron, Ramon C.

1999-01-01

The Fluid Combustion Facility (FCF) Project and the Power Technology Division at the NASA Glenn Research Center (GRC) at Lewis Field in Cleveland, OH along with the Sundstrand Corporation in Rockford, IL are jointly developing an Electrical Power Converter Unit (EPCU) for the Fluid Combustion Facility to be flown on the International Space Station (ISS). The FCF facility experiment contains three racks: A core rack, a combustion rack, and a fluids rack. The EPCU will be used as the power interface to the ISS 120V(sub dc) power distribution system by each FCF experiment rack which requires 28V(sub dc). The EPCU is a modular design which contains three 120V(sub dc)-to-28V(sub dc) full-bridge, power converters rated at 1 kW(sub e) each bus transferring input relays and solid-state, current-limiting input switches, 48 current-limiting, solid-state, output switches; and control and telemetry hardware. The EPCU has all controls required to autonomously share load demand between the power feeds and--if absolutely necessary--shed loads. The EPCU, which maximizes the usage of allocated ISS power and minimizes loss of power to loads, can be paralleled with other EPCUs. This paper overviews the electrical design and operating characteristics of the EPCU and presents test data from the breadboard design.

Sail GTS ground system analysis: Avionics system engineering

NASA Technical Reports Server (NTRS)

Lawton, R. M.

1977-01-01

A comparison of two different concepts for the guidance, navigation and control test set signal ground system is presented. The first is a concept utilizing a ground plate to which crew station, avionics racks, electrical power distribution system, master electrical common connection assembly and marshall mated elements system grounds are connected by 4/0 welding cable. An alternate approach has an aluminum sheet interconnecting the signal ground reference points between the crew station and avionics racks. The comparison analysis quantifies the differences between the two concepts in terms of dc resistance, ac resistance and inductive reactance. These parameters are figures of merit for ground system conductors in that the system with the lowest impedance is the most effective in minimizing noise voltage. Although the welding cable system is probably adequate, the aluminum sheet system provides a higher probability of a successful system design.

Asia Beyond the Border: Physical Geography - Central and Northeastern Asia -

DTIC Science & Technology

1961-03-21

expressed. In essence the presence of a great number of small enclosed salt lakes on the surface of the upland area is the cause for such arid...that level Alpane flora may be seen, such as the bistort, winterfat and the ra>ck jasmine . . _ . In the east the vegetation is more varied

SideRack: A Cost-Effective Addition to Commercial Zebrafish Housing Systems

PubMed Central

Burg, Leonard; Gill, Ryan; Balciuniene, Jorune

2014-01-01

Abstract Commercially available aquatic housing systems provide excellent and relatively trouble-free hardware for rearing and housing juvenile as well as adult zebrafish. However, the cost of such systems is quite high and potentially prohibitive for smaller educational and research institutions. The need for tank space prompted us to experiment with various additions to our existing Aquaneering system. We also noted that high water exchange rates typical in commercial systems are suboptimal for quick growth of juvenile fish. We devised a housing system we call “SideRack,” which contains 20 large tanks with air supply and slow water circulation. It enables cost-effective expansion of existing fish facility, with a key additional benefit of increased growth and maturation rates of juvenile fish. PMID:24611601

Mini-rack testbed evaluation

NASA Technical Reports Server (NTRS)

Gosbee, John; Stegmann, Barbara; Guess, Terrell M.

1991-01-01

The goal was to characterize the Health Maintenance Facility (HMF)-like mini-racks and drawers onboard the KC-135 as a test bed for the Space Station Freedom HMF racks. An additional goal was to evaluate the attachments, mounting points, and inner drawer assemblies of the mini-racks for various medical equipment and supplies. Results and recommendations are given.

76 FR 27990 - Certain Kitchen Shelving and Racks From the People's Republic of China: Extension of Time Limit...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-13

... Racks From the People's Republic of China: Extension of Time Limit for Preliminary Results of... countervailing duty order on certain kitchen appliance shelving and racks from the People's Republic of China... the Countervailing Duty Administrative Review of Certain Kitchen Appliance Shelving and Racks from the...

78 FR 78815 - Certain Kitchen Appliance Shelving and Racks from the People's Republic of China: Rescission of...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-27

... Shelving and Racks from the People's Republic of China: Rescission of Antidumping Duty Administrative... administrative review of the antidumping duty order on certain kitchen appliance shelving and racks from the... on certain kitchen appliance shelving and racks from the PRC.\\1\\ On September 30, 2013, the...

40 CFR 63.2475 - What requirements must I meet for transfer racks?

Code of Federal Regulations, 2010 CFR

2010-07-01

... transfer racks? 63.2475 Section 63.2475 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... must I meet for transfer racks? (a) You must comply with each emission limit and work practice standard in table 5 to this subpart that applies to your transfer racks, and you must meet each applicable...

30 CFR 56.7050 - Tool and drill steel racks.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Tool and drill steel racks. 56.7050 Section 56.7050 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND NONMETAL... Jet Piercing Drilling § 56.7050 Tool and drill steel racks. Receptacles or racks shall be provided for...

77 FR 72324 - Certain Kitchen Appliance Shelving and Racks from the People's Republic of China: Countervailing...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-05

... Shelving and Racks from the People's Republic of China: Countervailing Duty Administrative Review, 2010... countervailing duty order on certain kitchen appliance shelving and racks from the People's Republic of China. See Certain Kitchen Appliance Shelving and Racks From the People's Republic of China: Countervailing...

78 FR 21594 - Certain Kitchen Appliance Shelving and Racks From the People's Republic of China: Final Results...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-11

... Shelving and Racks From the People's Republic of China: Final Results of Countervailing Duty Administrative... countervailing duty (``CVD'') order on certain kitchen appliance shelving and racks from the People's Republic of...\\ See Certain Kitchen Appliance Shelving and Racks From the People's Republic of China: Countervailing...

30 CFR 57.7050 - Tool and drill steel racks.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Tool and drill steel racks. 57.7050 Section 57... Rotary Jet Piercing Drilling-Surface and Underground § 57.7050 Tool and drill steel racks. Receptacles or racks shall be provided for drill steel and tools stored or carried on drills. ...

30 CFR 57.7050 - Tool and drill steel racks.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 30 Mineral Resources 1 2011-07-01 2011-07-01 false Tool and drill steel racks. 57.7050 Section 57... Rotary Jet Piercing Drilling-Surface and Underground § 57.7050 Tool and drill steel racks. Receptacles or racks shall be provided for drill steel and tools stored or carried on drills. ...

30 CFR 57.7050 - Tool and drill steel racks.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 30 Mineral Resources 1 2014-07-01 2014-07-01 false Tool and drill steel racks. 57.7050 Section 57... Rotary Jet Piercing Drilling-Surface and Underground § 57.7050 Tool and drill steel racks. Receptacles or racks shall be provided for drill steel and tools stored or carried on drills. ...

30 CFR 57.7050 - Tool and drill steel racks.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 30 Mineral Resources 1 2013-07-01 2013-07-01 false Tool and drill steel racks. 57.7050 Section 57... Rotary Jet Piercing Drilling-Surface and Underground § 57.7050 Tool and drill steel racks. Receptacles or racks shall be provided for drill steel and tools stored or carried on drills. ...

30 CFR 57.7050 - Tool and drill steel racks.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 30 Mineral Resources 1 2012-07-01 2012-07-01 false Tool and drill steel racks. 57.7050 Section 57... Rotary Jet Piercing Drilling-Surface and Underground § 57.7050 Tool and drill steel racks. Receptacles or racks shall be provided for drill steel and tools stored or carried on drills. ...

Decreased Blastocyst Production in Mice Exposed to Increased Rack Noise

PubMed Central

Zamora, Bernadette M; Jiang, Meisheng; Wang, Ying; Chai, Minghua; Lawson, P Timothy; Lawson, Gregory W

2009-01-01

This study was conducted to investigate the possible effect of rack type on the blastocyst yield of mouse embryo donors. The first phase of the study consisted of housing some mice (group A) in a ventilated rack and others (group B) in a static rack in the same room for 3 d, followed by euthanasia for blastocyst collection and corticosterone assay. Parametric tests were used to compare groups. The number of blastocysts per donor was lower in group A (5.0 ± 1.4 blastocysts) than group B (13.1 ± 3.7 blastocysts). Mean noise was higher in the ventilated rack (80.4 dBC) than in the static rack (69.2 dBC). Serum corticosterone concentrations did not differ between groups. For the second phase of the study, a third group of mice (group C) was housed in a static rack without a ventilated rack in the same room. The noise level for group C was even lower (45.18 ± 2.91 dBC), and the blastocyst count per donor (16.4 ± 2.4) was higher than that of group B. The mean noise levels of empty ventilated and static racks differed significantly between groups for 10 different sound frequencies. Plotting mean blastocyst production against mean rack noise revealed a negative linear relationship with good strength of correlation. These results support the earlier observation that decreased blastocyst count occurs following housing of bred C57BL/6 donor mice in ventilated cages. PMID:19807968

RACK1 binds to Smad3 to modulate transforming growth factor-beta1-stimulated alpha2(I) collagen transcription in renal tubular epithelial cells.

PubMed

Okano, Kazuhiro; Schnaper, H William; Bomsztyk, Karol; Hayashida, Tomoko

2006-09-08

Although it is clear that transforming growth factor-beta1 (TGF-beta1) is critical for renal fibrogenesis, the complexity of the involved mechanisms is increasingly apparent. TGF-beta1 stimulates phosphorylation of Smad2/3 and activates other signaling molecules as well. The molecular link between these other kinases and Smads is not known. We sought new binding partners for Smad3 in renal cells and identified receptor for activated protein kinase C 1 (RACK1) as a novel binding partner of Smad3. The linker region of Smad3 and the tryptophan-aspartic acid repeat 6 and 7 of RACK1 are sufficient for the association. RACK1 also interacts with Smad3 in the human kidney epithelial cell line, HKC. Silencing RACK1 increases transcriptional activity of TGF-beta1-responsive promoter sequences of the Smad binding element (SBE), p3TP-Lux, and alpha2(I) collagen. Conversely, overexpressed RACK1 negatively modulates alpha2(I) collagen transcriptional activity in TGF-beta1-stimulated cells. RACK1 did not affect phosphorylation of Smad3 at the C terminus or in the linker region. However, RACK1 reduced direct binding of Smad3 to the SBE motif. Mutating a RACK1 tyrosine at residue 246, but not at 228, decreased the inhibitory effect of RACK1 on both alpha2(I) collagen promoter activity and Smad binding to SBE induced by TGF-beta1. These results suggest that RACK1 modulates transcription of alpha2(I) collagen by TGF-beta1 through interference with Smad3 binding to the gene promoter.

KSC-08pd3209

NASA Image and Video Library

2008-10-17

CAPE CANAVERAL, Fla. – This photo shows the Water Recovery System's rack 2, that will be delivered to the International Space Station aboard space shuttle Endeavour on the STS-126 mission. Its primary purpose is to process urine and waster water so that Waste Recovery System's rack 1 can perform the final cleanup. The two units of the Water Recovery System are designed to provide drinking-quality water through the reclamation of wastewater, including urine and hygiene wastes. The water that’s produced will be used to support the crew and work aboard the station. Endeavour and its crew of seven are scheduled to lift off at 7:55 p.m. Nov. 14 for the 15-day STS-126 mission. Photo credit: NASA

78 FR 57215 - Waiver of Requirement To Enter Into a Reciprocal Waiver of Claims Agreement With All Customers...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-09-17

... NanoRacks, LLC, and NanoRacks locker insert and student experiments created under NASA's Student..., and mathematics education initiative.\\2\\ According to its Space Act Agreement with NASA,\\3\\ NanoRacks... opportunities to NanoRacks for the launch of its insert and the experiments the insert carries. Orbital provided...

77 FR 12811 - Certain Kitchen Appliance Shelving and Racks From the People's Republic of China: Partial...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-02

... Shelving and Racks From the People's Republic of China: Partial Rescission of Antidumping Duty... review of the antidumping duty order on certain kitchen appliance shelving and racks from the People's... Appliance Shelving and Racks from the People's Republic of China, dated January 10, 2012; and Letter to the...

76 FR 20950 - Certain Kitchen Appliance Shelving and Racks From the People's Republic of China: Extension of...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-14

... Shelving and Racks From the People's Republic of China: Extension of Time Limits for the Preliminary... appliance shelving and racks from the People's Republic of China (``PRC'') for the period March 5, 2009... Racks from the People's Republic of China,'' dated January 20, 2011. The Department sent its antidumping...

26 CFR 48.4081-3 - Taxable fuel; taxable events other than removal at the terminal rack.

Code of Federal Regulations, 2010 CFR

2010-04-01

... at the terminal rack. 48.4081-3 Section 48.4081-3 Internal Revenue INTERNAL REVENUE SERVICE...; taxable events other than removal at the terminal rack. (a) Overview. Although tax is imposed when taxable fuel is removed from the terminal at the rack, tax also is imposed in certain other situations...

77 FR 22559 - Certain Kitchen Appliance Shelving and Racks From the People's Republic of China: Extension of...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-16

... Shelving and Racks From the People's Republic of China: Extension of Time Limit for the Preliminary Results... administrative review of the antidumping duty order on certain kitchen appliance shelving and racks from the... Appliance Shelving and Racks from the People's Republic of China: Selection of an Additional Mandatory...

78 FR 5414 - Certain Kitchen Appliance Shelving and Racks From the People's Republic of China; 2010-2011...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-01-25

... Shelving and Racks From the People's Republic of China; 2010-2011; Final Results of Antidumping Duty... of the antidumping duty order on certain kitchen appliance shelving and racks from the People's... September 1, 2010, through August 31, 2011. \\1\\ See Certain Kitchen Appliance Shelving and Racks From the...

77 FR 61385 - Certain Kitchen Appliance Shelving and Racks From the People's Republic of China: Antidumping...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-09

... Shelving and Racks From the People's Republic of China: Antidumping Duty Administrative Review, 2010-2011... administrative review of the antidumping duty order on certain kitchen appliance shelving and racks from the... INFORMATION: Scope of the Order The scope of this order consists of shelving and racks for refrigerators...

77 FR 82 - Certain Kitchen Appliance Shelving and Racks From the People's Republic of China: Extension of...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-01-03

... Shelving and Racks From the People's Republic of China: Extension of Time Limit for the Final Results of... administrative review of the countervailing duty order on certain kitchen appliance shelving and racks from the... Kitchen Appliance Shelving and Racks From the People's Republic of China: Preliminary Results of the...

Fatal accident cause and conclusion.

PubMed

Tsach, Tsadok; Cohen, Aviva; Finegold, George

2009-01-01

The Toolmarks Laboratory prepared a report concerning a traffic accident involving the death of a road workman. The driver of the vehicle that hit the workman claimed that the wheels had failed to respond when turning left at a roundabout. A traffic investigator photographed the rack and pinion assembly of the steering system, which was subsequently removed and brought to the Toolmarks Laboratory. The rack and pinion assembly of the steering system was rebuilt, and examination showed that the system functioned properly. Specifically, the front wheels responded correctly to the steering input. Laboratory photographs of the steering system were taken in two different positions, from the same angles as the investigator's photographs at the scene of the accident. It was clear that the steering system had not been assembled properly in the garage.

STS-98 crew checks out the U.S. Lab Destiny in Atlantis' payload bay

NASA Technical Reports Server (NTRS)

2001-01-01

KENNEDY SPACE CENTER, Fla. -- Members of the STS-98 crew, along with Scott Thurston (left), with the VITT office, check out the U.S. Lab Destiny in the payload bay of the orbiter Atlantis. Wearing white caps are Commander Ken Cockrell (center) and Mission Specialist Marsha Ivins (right). The crew is at KSC for Terminal Countdown Demonstration Test activities, which include a simulated launch countdown. Destiny, a key element in the construction of the International Space Station, is a pressurized module designed to accommodate pressurized payloads. It has a capacity of 24 rack locations. Payload racks will occupy 13 locations especially designed to support experiments. The module already has five system racks installed inside. Launch of STS-98 on its 11-day mission is scheduled for Jan. 19 at 2:11 a.m. EST.

STS-98 crew checks out the U.S. Lab Destiny in Atlantis' payload bay

NASA Technical Reports Server (NTRS)

2001-01-01

KENNEDY SPACE CENTER, Fla. -- Along with Scott Thurston (left), of the VITT office, members of the STS-98 crew Mission Specialist Robert Curbeam, Commander Ken Cockrell and Mission Specialist Marsha Ivins are in Atlantis''' payload bay to check out their mission payload, the U.S. Lab Destiny. The crew is at KSC for Terminal Countdown Demonstration Test activities, which also include a simulated launch countdown. A key element in the construction of the International Space Station, Destiny is a pressurized module designed to accommodate pressurized payloads. It has a capacity of 24 rack locations. Payload racks will occupy 13 locations especially designed to support experiments. The module already has five system racks installed inside. Launch of STS-98 on its 11-day mission is scheduled for Jan. 19 at 2:11 a.m. EST.

STS-98 crew checks out the U.S. Lab Destiny in Atlantis' payload bay

NASA Technical Reports Server (NTRS)

2001-01-01

KENNEDY SPACE CENTER, Fla. -- STS-98 Mission Specialist Robert Curbeam (left), Commander Ken Cockrell (center) and Mission Specialist Marsha Ivins (right) look over the U.S. Lab Destiny in the payload bay of the orbiter Atlantis. Behind Ivins is Scott Thurston, of the VITT office. The crew is at KSC for Terminal Countdown Demonstration Test activities, which also include a simulated launch countdown. A key element in the construction of the International Space Station, Destiny is a pressurized module designed to accommodate pressurized payloads. It has a capacity of 24 rack locations. Payload racks will occupy 13 locations especially designed to support experiments. The module already has five system racks installed inside. Launch of STS-98 on its 11-day mission is scheduled for Jan. 19 at 2:11 a.m. EST.

STS-100 MPLM Raffaello is moved to the payload canister

NASA Technical Reports Server (NTRS)

2001-01-01

KENNEDY SPACE CENTER, Fla. - In the Space Station Processing Facility, the Multi-Purpose Logistics Module Raffaello rises off the workstand via an overhead crane that will move it to the payload canister. Part of the payload on mission STS-100 to the International Space Station, Raffaello carries six system racks and two storage racks for the U.S. Lab. Launch of STS-100 is scheduled for April 19, 2001 at 2:41 p.m. EDT from Launch Pad 39A.

STS-100 MPLM Raffaello is moved to the payload canister

NASA Technical Reports Server (NTRS)

2001-01-01

KENNEDY SPACE CENTER, Fla. - In the Space Station Processing Facility, an overhead crane is attached to the Multi-Purpose Logistics Module Raffaello in order to move the MPLM to the payload canister. Part of the payload on mission STS-100 to the International Space Station, Raffaello carries six system racks and two storage racks for the U.S. Lab. Launch of STS-100 is scheduled for April 19, 2001 at 2:41 p.m. EDT from Launch Pad 39A.

STS-100 MPLM Raffaello is moved to the payload canister

NASA Technical Reports Server (NTRS)

2001-01-01

KENNEDY SPACE CENTER, Fla. - The overhead crane in the Space Station Processing Facility traverses the length of the SSPF with the Multi-Purpose Logistics Module Raffaello to reach the payload canister. Part of the payload on mission STS-100 to the International Space Station, Raffaello carries six system racks and two storage racks for the U.S. Lab. Launch of STS-100 is scheduled for April 19, 2001 at 2:41 p.m. EDT from Launch Pad 39A.

STS-100 MPLM Raffaello is moved to the payload canister

NASA Technical Reports Server (NTRS)

2001-01-01

KENNEDY SPACE CENTER, Fla. - In the Space Station Processing Facility, workers on the floor walk along with the suspended Multi-Purpose Logistics Module Raffaello traveling overhead to the payload canister at right. Part of the payload on mission STS-100 to the International Space Station, Raffaello carries six system racks and two storage racks for the U.S. Lab. Launch of STS-100 is scheduled for April 19, 2001 at 2:41 p.m. EDT from Launch Pad 39A.

STS-100 MPLM Raffaello is moved to the payload canister

NASA Technical Reports Server (NTRS)

2001-01-01

KENNEDY SPACE CENTER, Fla. - In the Space Station Processing Facility, an overhead crane is ready to lift the Multi-Purpose Logistics Module Raffaello in order to move it to the payload canister. Part of the payload on mission STS-100 to the International Space Station, Raffaello carries six system racks and two storage racks for the U.S. Lab. Launch of STS-100 is scheduled for April 19, 2001 at 2:41 p.m. EDT from Launch Pad 39A.

40 CFR 63.2386 - What reports must I submit and when and what information is to be submitted in each?

Code of Federal Regulations, 2010 CFR

2010-07-01

... organic liquids were loaded at transfer racks that are subject to control based on the criteria specified... all transfer racks (except those racks at which only unloading of organic liquids occurs) and of tanks...) For each storage tank and transfer rack subject to control requirements, include periods of planned...

KSC-04PD-2497

NASA Technical Reports Server (NTRS)

2004-01-01

KENNEDY SPACE CENTER, FLA. Joe Mounts, with Boeing, monitors the Payload Test and Checkout System for the Human Research Facility (HRF) Rack -2 payload. The HRF-2 is scheduled to fly on Return to Flight Space Shuttle mission STS-114. The HRF-2 will deliver additional biomedical instrumentation and research capability to the International Space Station. HRF Rack 1 contains an ultrasound unit and gas analyzer system and has been operational in the U.S. Lab since May 2001. HRF-2 will also be installed in the U. S. Lab and will provide structural, power, thermal, command and data handling, and communication and tracking interfaces between the HRF biomedical instrumentation and the U. S. Lab.

Whitson looks at the ADVASC Soybean plant growth experiment in the U.S. Laboratory

NASA Image and Video Library

2002-07-10

ISS005-E-07212 (10 July 2002) --- NASA Astronaut Peggy Whitson, Expedition 5 International Space Station (ISS) science officer, looks at the Advanced Astroculture (ADVASC) Soybean plant growth experiment as part of Expediting the Process of Experiments to the Space Station (EXPRESS) Rack 4 located in the U.S. Laboratory Destiny.

A "Kane's Dynamics" Model for the Active Rack Isolation System. Part 3; Addition of Umbilicals to the Nonlinear Model

NASA Technical Reports Server (NTRS)

Rupert, J. K.; Hampton, R. D.; Beech, G. S.

2005-01-01

In the late 1980s, microgravity researchers began to voice their concern that umbilical-transmitted energy could significantly degrade the acceleration environment of microgravity space science experiments onboard manned spacecraft. Since umbilicals are necessary for many experiments, control designers began to seek ways to compensate for these "indirect" disturbances. Hampton, et al., used the Kane s method to develop a model of the active rack isolation system (ARIS) that includes (1) actuator control forces, (2) direct disturbance forces, and (3) indirect, actuator-transmitted disturbances. Their model does not, however, include the indirect, umbilical-transmitted disturbances. Since the umbilical stiffnesses are not negligible, these indirect disturbances must be included in the model. Until the umbilicals have been appropriately included, the model will be incomplete. This Technical Memorandum presents a nonlinear model of ARIS with umbilicals included. Model verification was achieved by utilizing two commercial-off-the-shelf software tools. Various forces and moments were applied to the model to yield simulated responses of the system. Plots of the simulation results show how various critical points on an ARIS-outfitted international standard payload rack behave under the application of direct disturbances, indirect disturbances, and control forces. Simulations also show system response to a variety of initial conditions.

THE FLUIDS AND COMBUSTION FACILITY: ENABLING THE EXPLORATION OF SPACE

NASA Technical Reports Server (NTRS)

Weiland, Karen J.; Gati, Frank G.; Hill, Myron E.; OMalley, Terence; Zurawski, Robert L.

2005-01-01

The Fluids and Combustion Facility (FCF) is an International Space Station facility designed to support physical and biological research as well as technology experiments in space. The FCF consists of two racks called the Combustion Integrated Rack (CIR) and the Fluids Integrated Rack (FIR). The capabilities of the CIR and the FIR and plans for their utilization will support the President s vision for space exploration. The CIR will accommodate physical research and technology experiments that address needs in the areas of spacecraft fire prevention, detection and suppression, incineration of solid wastes, and power generation. Initial experiments will provide data to support design decisions for exploration spacecraft. The CIR provides a large sealed chamber in a near-weightless environment. The chamber supports many simulated atmospheres including lunar or Martian environments. The FIR will accommodate experiments that address needs for advanced life support, power, propulsion, and spacecraft thermal control systems. The FIR can also serve as a platform for experiments that address human health and performance, medical technologies, and biological sciences. The FIR provides a large volume for payload hardware, reconfigurable diagnostics, customizable software, active rack-level vibration isolation, and data acquisition and management in a nearly uniform temperature environment.

The Fluids and Combustion Facility: Enabling the Exploration of Space

NASA Technical Reports Server (NTRS)

Weiland, Karen J.; Gati, Frank G.; Hill, Myron E.; O'Malley Terence F.; Zurawski, Robert L.

2005-01-01

The Fluids and Combustion Facility (FCF) is an International Space Station facility designed to support physical and biological research as well as technology experiments in space. The FCF consists of two racks called the Combustion Integrated Rack (CIR) and the Fluids Integrated Rack (FIR). The capabilities of the CIR and the FIR and plans for their utilization will support the President's vision for space exploration. The CIR will accommodate physical research and technology experiments that address needs in the areas of spacecraft fire prevention, detection and suppression, incineration of solid wastes, and power generation. Initial experiments will provide data to support design decisions for exploration spacecraft. The CIR provides a large sealed chamber in a near-weightless environment. The chamber supports many simulated atmospheres including lunar or Martian environments. The FIR will accommodate experiments that address needs for advanced life support, power, propulsion, and spacecraft thermal control systems. The FIR can also serve as a platform for experiments that address human health and performance, medical technologies, and biological sciences. The FIR provides a large volume for payload hardware, reconfigurable diagnostics, customizable software, active rack-level vibration isolation, and data acquisition and management in a nearly uniform temperature environment.

The effects of video compression on acceptability of images for monitoring life sciences' experiments

NASA Technical Reports Server (NTRS)

Haines, Richard F.; Chuang, Sherry L.

1993-01-01

Current plans indicate that there will be a large number of life science experiments carried out during the thirty year-long mission of the Biological Flight Research Laboratory (BFRL) on board Space Station Freedom (SSF). Non-human life science experiments will be performed in the BFRL. Two distinct types of activities have already been identified for this facility: (1) collect, store, distribute, analyze and manage engineering and science data from the Habitats, Glovebox and Centrifuge, (2) perform a broad range of remote science activities in the Glovebox and Habitat chambers in conjunction with the remotely located principal investigator (PI). These activities require extensive video coverage, viewing and/or recording and distribution to video displays on board SSF and to the ground. This paper concentrates mainly on the second type of activity. Each of the two BFRL habitat racks are designed to be configurable for either six rodent habitats per rack, four plant habitats per rack, or a combination of the above. Two video cameras will be installed in each habitat with a spare attachment for a third camera when needed. Therefore, a video system that can accommodate up to 12-18 camera inputs per habitat rack must be considered.

First Materials Science Research Facility Rack Capabilities and Design Features

NASA Technical Reports Server (NTRS)

Cobb, S.; Higgins, D.; Kitchens, L.; Curreri, Peter (Technical Monitor)

2002-01-01

The first Materials Science Research Rack (MSRR-1) is the primary facility for U.S. sponsored materials science research on the International Space Station. MSRR-1 is contained in an International Standard Payload Rack (ISPR) equipped with the Active Rack Isolation System (ARIS) for the best possible microgravity environment. MSRR-1 will accommodate dual Experiment Modules and provide simultaneous on-orbit processing operations capability. The first Experiment Module for the MSRR-1, the Materials Science Laboratory (MSL), is an international cooperative activity between NASA's Marshall Space Flight Center (MSFC) and the European Space Agency's (ESA) European Space Research and Technology Center (ESTEC). The MSL Experiment Module will accommodate several on-orbit exchangeable experiment-specific Module Inserts which provide distinct thermal processing capabilities. Module Inserts currently planned for the MSL are a Quench Module Insert, Low Gradient Furnace, and a Solidification with Quench Furnace. The second Experiment Module for the MSRR-1 configuration is a commercial device supplied by MSFC's Space Products Development (SPD) Group. Transparent furnace assemblies include capabilities for vapor transport processes and annealing of glass fiber preforms. This Experiment Module is replaceable on-orbit. This paper will describe facility capabilities, schedule to flight and research opportunities.

O-GlcNAcylation of RACK1 promotes hepatocellular carcinogenesis.

PubMed

Duan, Fangfang; Wu, Hao; Jia, Dongwei; Wu, Weicheng; Ren, Shifang; Wang, Lan; Song, Shushu; Guo, Xinying; Liu, Fenglin; Ruan, Yuanyuan; Gu, Jianxin

2018-06-01

Aberrant oncogenic mRNA translation and protein O-linked β-N-acetylglucosaminylation (O-GlcNAcylation) are general features during tumorigenesis. Nevertheless, whether and how these two pathways are interlinked remain unknown. Our previous study indicated that ribosomal receptor for activated C-kinase 1 (RACK1) promoted chemoresistance and growth in hepatocellular carcinoma (HCC). The aim of this study is to examine the role of RACK1 O-GlcNAcylation in oncogene translation and HCC carcinogenesis. The site(s) of RACK1 for O-GlcNAcylation was mapped by mass spectrometry analysis. HCC cell lines were employed to examine the effects of RACK1 O-GlcNAcylation on the translation of oncogenic factors and behaviors of tumor cells in vitro. Transgenic knock-in mice were used to detect the role of RACK1 O-GlcNAcylation in modulating HCC tumorigenesis in vivo. The correlation of RACK1 O-GlcNAcylation with tumor progression and relapse were analyzed in clinical HCC samples. We found that ribosomal RACK1 was highly modified by O-GlcNAc at Ser122. O-GlcNAcylation of RACK1 enhanced its protein stability, ribosome binding and interaction with PKCβII (PRKCB), leading to increased eukaryotic translation initiation factor 4E phosphorylation and translation of potent oncogenes in HCC cells. Genetic ablation of RACK1 O-GlcNAcylation at Ser122 dramatically suppressed tumorigenesis, angiogenesis, and metastasis in vitro and in diethylnitrosamine (DEN)-induced HCC mouse model. Increased RACK1 O-GlcNAcylation was also observed in HCC patient samples and correlated with tumor development and recurrence after chemotherapy. These findings demonstrate that RACK1 acts as key mediator linking O-GlcNAc metabolism to cap-dependent translation during HCC tumorigenesis. Targeting RACK1 O-GlcNAcylation provides promising options for HCC treatment. O-GlcNAcylation of ribosomal receptor for activated C-kinase 1 at the amino acid serine122 promotes its stability, ribosome localization and interaction with the protein kinase, PKCβII, thus driving the translation of oncogenes and tumorigenesis of hepatocellular carcinoma. Increased O-GlcNAcylation of ribosomal receptor for activated C-kinase 1 is positively correlated with tumor growth, metastasis and recurrence in patients with hepatocellular carcinoma. Copyright © 2018 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.

26 CFR 48.4081-2 - Taxable fuel; tax on removal at a terminal rack.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 26 Internal Revenue 16 2010-04-01 2010-04-01 true Taxable fuel; tax on removal at a terminal rack..., Tread Rubber, and Taxable Fuel Taxable Fuel § 48.4081-2 Taxable fuel; tax on removal at a terminal rack... rack are subject to tax and the position holder with respect to the fuel is liable for the tax. (b...

Advanced life support study

NASA Technical Reports Server (NTRS)

1991-01-01

Summary reports on each of the eight tasks undertaken by this contract are given. Discussed here is an evaluation of a Closed Ecological Life Support System (CELSS), including modeling and analysis of Physical/Chemical Closed Loop Life Support (P/C CLLS); the Environmental Control and Life Support Systems (ECLSS) evolution - Intermodule Ventilation study; advanced technologies interface requirements relative to ECLSS; an ECLSS resupply analysis; the ECLSS module addition relocation systems engineering analysis; an ECLSS cost/benefit analysis to identify rack-level interface requirements of the alternate technologies evaluated in the ventilation study, with a comparison of these with the rack level interface requirements for the baseline technologies; advanced instrumentation - technology database enhancement; and a clean room survey and assessment of various ECLSS evaluation options for different growth scenarios.

Racking strength of walls sheathed with structual flakeboards made from southern species

Treesearch

E.W. Price; Gromala D.S.

1980-01-01

Ten types of structural flakeboards and two types of southern pine plywood were evaluated. Racking loads were applied to full-size racking panels (8 by 8 ft., according to ASTME 72) and small panels (2 by 2 ft.). When subjected to a 1,600-pound racking load, 8- by 8-foot panels sheathed with flakeboards containing a mixture of hardwood and pine flakes were slightly...

75 FR 8549 - Airworthiness Directives; Airbus Model A300 Series Airplanes, Airbus Model A300 B4-600 Series...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-02-25

... rack 101VU by accomplishment of Airbus Service Bulletin (SB) A310-53-2076 was embodied on the aeroplane... the splicing with rack 107VU fitting. This condition, if not detected and corrected, could degrade the structural integrity of the crossbeam on NLG FR15A web attachment fitting of rack 107VU. Rack 107VU contains...

RACK1, a clue to the diagnosis of cutaneous melanomas in horses.

PubMed

Campagne, Cécile; Julé, Sophia; Bernex, Florence; Estrada, Mercedes; Aubin-Houzelstein, Geneviève; Panthier, Jean-Jacques; Egidy, Giorgia

2012-06-29

Melanocytic proliferations are common in horses but the diagnosis of malignancy is not always straightforward. To improve diagnosis and prognosis, markers of malignancy are needed. Receptor for activated C kinase 1 (RACK1) protein may be such a marker. RACK1 was originally found to characterize malignant melanocytic lesions in the Melanoblastoma-bearing Libechov minipig (MeLiM) and, later, in human patients. Our purpose was to investigate the value of RACK1 in the classification of cutaneous melanocytic proliferations in horses. Using immunofluorescence, we report here that both MITF (Microphthalmia-associated transcription factor) and PAX3 (Paired box 3) allow the identification of melanocytic cells in horse skin samples. Importantly, RACK1 was detected in melanocytic lesions but not in healthy skin melanocytes. Finally, we found that RACK1 labeling can be used in horses to distinguish benign melanocytic tumors from melanomas. Indeed, RACK1 labeling appeared more informative to assess malignancy than individual histomorphological features. This study confirms that horses provide an interesting model for melanoma genesis studies. It establishes MITF and PAX3 as markers of horse melanocytic cells. RACK1 emerges as an important marker of malignancy which may contribute to progress in the diagnosis of melanomas in both human and veterinary medicine.

RACK1, a clue to the diagnosis of cutaneous melanomas in horses

PubMed Central

2012-01-01

Background Melanocytic proliferations are common in horses but the diagnosis of malignancy is not always straightforward. To improve diagnosis and prognosis, markers of malignancy are needed. Receptor for activated C kinase 1 (RACK1) protein may be such a marker. RACK1 was originally found to characterize malignant melanocytic lesions in the Melanoblastoma-bearing Libechov minipig (MeLiM) and, later, in human patients. Our purpose was to investigate the value of RACK1 in the classification of cutaneous melanocytic proliferations in horses. Results Using immunofluorescence, we report here that both MITF (Microphthalmia-associated transcription factor) and PAX3 (Paired box 3) allow the identification of melanocytic cells in horse skin samples. Importantly, RACK1 was detected in melanocytic lesions but not in healthy skin melanocytes. Finally, we found that RACK1 labeling can be used in horses to distinguish benign melanocytic tumors from melanomas. Indeed, RACK1 labeling appeared more informative to assess malignancy than individual histomorphological features. Conclusions This study confirms that horses provide an interesting model for melanoma genesis studies. It establishes MITF and PAX3 as markers of horse melanocytic cells. RACK1 emerges as an important marker of malignancy which may contribute to progress in the diagnosis of melanomas in both human and veterinary medicine. PMID:22747534

KSC-04PD-2495

NASA Technical Reports Server (NTRS)

2004-01-01

KENNEDY SPACE CENTER, FLA. Nancy Lowry (left) and Mikiko Ujihara, with Boeing, monitor the Payload Test and Checkout System for the Human Research Facility (HRF) Rack -2 payload. The HRF-2 is scheduled to fly on Return to Flight Space Shuttle mission STS- 114. The HRF-2 will deliver additional biomedical instrumentation and research capability to the International Space Station. HRF Rack 1 contains an ultrasound unit and gas analyzer system and has been operational in the U.S. Lab since May 2001. HRF-2 will also be installed in the U. S. Lab and will provide structural, power, thermal, command and data handling, and communication and tracking interfaces between the HRF biomedical instrumentation and the U. S. Lab.

AMO EXPRESS: A Command and Control Experiment for Crew Autonomy Onboard the International Space Station

NASA Technical Reports Server (NTRS)

Stetson, Howard K.; Frank, Jeremy; Cornelius, Randy; Haddock, Angie; Wang, Lui; Garner, Larry

2015-01-01

NASA is investigating a range of future human spaceflight missions, including both Mars-distance and Near Earth Object (NEO) targets. Of significant importance for these missions is the balance between crew autonomy and vehicle automation. As distance from Earth results in increasing communication delays, future crews need both the capability and authority to independently make decisions. However, small crews cannot take on all functions performed by ground today, and so vehicles must be more automated to reduce the crew workload for such missions. NASA's Advanced Exploration Systems Program funded Autonomous Mission Operations (AMO) project conducted an autonomous command and control experiment on-board the International Space Station that demonstrated single action intelligent procedures for crew command and control. The target problem was to enable crew initialization of a facility class rack with power and thermal interfaces, and involving core and payload command and telemetry processing, without support from ground controllers. This autonomous operations capability is enabling in scenarios such as initialization of a medical facility to respond to a crew medical emergency, and representative of other spacecraft autonomy challenges. The experiment was conducted using the Expedite the Processing of Experiments for Space Station (EXPRESS) rack 7, which was located in the Port 2 location within the U.S Laboratory onboard the International Space Station (ISS). Activation and deactivation of this facility is time consuming and operationally intensive, requiring coordination of three flight control positions, 47 nominal steps, 57 commands, 276 telemetry checks, and coordination of multiple ISS systems (both core and payload). Utilization of Draper Laboratory's Timeliner software, deployed on-board the ISS within the Command and Control (C&C) computers and the Payload computers, allowed development of the automated procedures specific to ISS without having to certify and employ novel software for procedure development and execution. The procedures contained the ground procedure logic and actions as possible to include fault detection and recovery capabilities.

Activated protein kinase C binds to intracellular receptors in rat hepatocytes.

PubMed

Robles-Flores, M; García-Sáinz, J A

1993-12-01

The aim of this study was to identify in rat hepatocytes cellular polypeptides that bind protein kinase C (PKC) and may influence its activity and its compartmentation. At least seven proteins, with apparent M(r) values between 12,000 and 36,000, that behave like Receptors for Activated C-Kinase (RACKs) were found in the Triton-X-100-insoluble fraction of these cells; i.e. PKC bound to these polypeptides when it was in its active form. RACKS seem to be PKC substrates. Studies using isotype-specific PKC antibodies suggested some selectivity of RACKs, i.e. RACKs in the M(r) approximately 28,000-36,000 region bound PKC-alpha and PKC-beta in the presence of phosphatidylserine, diolein and Ca2+, whereas those of M(r) approximately 12,000-14,000 bound all isoforms studied, and, in contrast with the other RACKs, they did this even in the absence of Ca2+. Peptide I (KGDYEKILVALCGGN), which has a sequence suggested to be involved in the PKC-RACKs interaction [Mochly-Rosen, Khaner, Lopez and Smith (1991) J. Biol. Chem. 266, 14866-14868], inhibited PKC activity. Preincubation of RACKs with antisera directed against peptide I prevented PKC binding to them. The data suggest that peptide I blocks PKC binding to RACKs by two mechanisms: inhibition of PKC activity and competition with a putative binding site.

Habitat use by Red Knots (Calidris canutus rufa): Experiments with oyster racks and reefs on the beach and intertidal of Delaware Bay, New Jersey

NASA Astrophysics Data System (ADS)

Burger, Joanna; Niles, Lawrence J.

2017-07-01

Sea level rise and increasing human activities have decreased intertidal habitat in many places in the world. The expansion of aquaculture in intertidal areas may impact birds and other organisms using these habitats, leading to questions of sustainability of both aquaculture and functioning estuarine ecosystems. Understanding the effect of oyster culture on shorebird activity, particularly on Red Knots (Calidris canutus rufa), a species on the U.S. Threatened List, is important for adaptive management and the expansion of oyster culture. In May 2013 we experimentally compared Red Knot and shorebird use of a beach section with racks and a control, and in 2016 we compared the use of sections with artificial reefs, oyster racks, and control on Delaware Bay, New Jersey (USA). The data included only times when no workers or other people were present. Censuses, conducted every 30 min throughout the day (279 censuses in 2013, 231 censuses in 2016), included the number of Red Knots and other shorebirds in each treatment section. In 2013, the total number of shorebirds was significantly higher in the rack section than in the control section, except for Red Knots and Ruddy Turnstones (Arenaria interpres) that occurred in higher numbers in the control than in the rack section. In 2016 Red Knot numbers were also significantly lower in the rack section. In 2013, the mean number of Red Knots/census was 13 for racks vs 59 for the control (P < 0.0002). In 2016, the mean number of Red Knots/census was 13 for racks and over 68 for other treatments (P < 0.0001). Treatment, date, and number of non-Knot shorebirds explained 60% (2013) and 69% (2016) of the variation in Red Knot numbers. Red Knots avoided the sections with racks while both foraging and roosting, suggesting that caution should be used before placing oyster racks in areas used for foraging by Red Knots.

Investigation of flow in data rack

NASA Astrophysics Data System (ADS)

Manoch, Lukáš; Nožička, Jiří; Pohan, Petr

2012-04-01

The main purpose of this paper was to set up a functioning numerical model of data rack verified by an experimental measurement. The verification of the numerical model was carried out by means of the PIV method (Particle Image Velocimetry). The numerical model was "found" while using the assumed and preset values from the experimental measurement which represent boundary conditions. The server model was conceived as a four-channel with a controlled flow rate without simulation of heat transfer. The flow rate in each channel was implemented by means of pressure loss. The numerical model was further used for simulation of several phases and configurations of data rack (21U rack space) fitted with two server workstations Dell Precision R5400. The flow field in the inlet of data rack in the front of the workstations were observed and evaluated in such a way that a 2U-dimensional free space between the workstations was being left and the remaining inlet space was blanked-off/fully opened. The results of this paper will serve for designing optimization treatment of data rack from the viewpoint of cooling efficiency both within the data rack and within the data center design.

International Space Station (ISS)

NASA Image and Video Library

2001-02-01

The Marshall Space Flight Center (MSFC) is responsible for designing and building the life support systems that will provide the crew of the International Space Station (ISS) a comfortable environment in which to live and work. Scientists and engineers at the MSFC are working together to provide the ISS with systems that are safe, efficient and cost-effective. These compact and powerful systems are collectively called the Environmental Control and Life Support Systems, or simply, ECLSS. This is an exterior view of the U.S. Laboratory Module Simulator containing the ECLSS Internal Thermal Control System (ITCS) testing facility at MSFC. At the bottom right is the data acquisition and control computers (in the blue equipment racks) that monitor the testing in the facility. The ITCS simulator facility duplicates the function, operation, and troubleshooting problems of the ITCS. The main function of the ITCS is to control the temperature of equipment and hardware installed in a typical ISS Payload Rack.

40 CFR 63.1105 - Transfer racks.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 10 2010-07-01 2010-07-01 false Transfer racks. 63.1105 Section 63.1105 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED... Technology Standards § 63.1105 Transfer racks. (a) Design requirements. The owner or operator shall equip...

Casimir rack and pinion as a miniaturized kinetic energy harvester

NASA Astrophysics Data System (ADS)

Miri, MirFaez; Etesami, Zahra

2016-08-01

We study a nanoscale machine composed of a rack and a pinion with no contact, but intermeshed via the lateral Casimir force. We adopt a simple model for the random velocity of the rack subject to external random forces, namely, a dichotomous noise with zero mean value. We show that the pinion, even when it experiences random thermal torque, can do work against a load. The device thus converts the kinetic energy of the random motions of the rack into useful work.

Phospholipase C-gamma 1 binding to intracellular receptors for activated protein kinase C.

PubMed

Disatnik, M H; Hernandez-Sotomayor, S M; Jones, G; Carpenter, G; Mochly-Rosen, D

1994-01-18

Phospholipase C-gamma 1 (PLC-gamma 1; EC 3.1.4.11) hydrolyzes phosphatidylinositol 4,5-bisphosphate to generate diacylglycerol and inositol 1,4,5-trisphosphate and is activated in response to growth factor stimulation and tyrosine phosphorylation. Concomitantly, the enzyme translocates from the cytosol to the particulate cell fraction. A similar process of activation-induced translocation from the cytosol to the cell particulate fraction has also been described for protein kinase C (PKC). We have previously shown that activated PKC binds to specific receptor proteins, receptors for activated C kinase, or RACKs, of approximately 30 kDa. Here, we show that PLC-gamma 1 bound to these RACKs and inhibited subsequent PKC binding to RACKs. However, unlike PKC, the binding of PLC-gamma 1 to RACKs did not require phospholipids and calcium. After epidermal growth factor treatment of intact A-431 cells, the binding of PLC-gamma 1 to RACKs increased as compared with PLC-gamma 1 from control cells. This increase in PLC-gamma 1 binding to RACKs was due to the phosphorylation of PLC-gamma 1. Additional data indicated that PLC-gamma 1 binds to RACKs in solution; epidermal growth factor receptor-dependent PLC-gamma 1 phosphorylation and activation decreased in the presence of RACKs. It is possible that, in vivo, PLC-gamma 1 associates with RACKs or with other PLC-gamma 1-specific anchoring proteins in the particulate cell fraction. Since a PKC C2 homologous region is present in PLC-gamma 1, the C2 region may mediate the activation-induced translocation of the enzyme to the cell particulate fraction and the anchoring protein-PLC-gamma 1 complex may be the active translocated form of PLC-gamma 1.

40 CFR 63.650 - Gasoline loading rack provisions.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 10 2011-07-01 2011-07-01 false Gasoline loading rack provisions. 63...) National Emission Standards for Hazardous Air Pollutants From Petroleum Refineries § 63.650 Gasoline... or operator of a Group 1 gasoline loading rack classified under Standard Industrial Classification...

40 CFR 63.650 - Gasoline loading rack provisions.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 10 2010-07-01 2010-07-01 false Gasoline loading rack provisions. 63...) National Emission Standards for Hazardous Air Pollutants From Petroleum Refineries § 63.650 Gasoline... or operator of a Group 1 gasoline loading rack classified under Standard Industrial Classification...

40 CFR 63.650 - Gasoline loading rack provisions.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 11 2012-07-01 2012-07-01 false Gasoline loading rack provisions. 63...) National Emission Standards for Hazardous Air Pollutants From Petroleum Refineries § 63.650 Gasoline... or operator of a Group 1 gasoline loading rack classified under Standard Industrial Classification...

40 CFR 63.650 - Gasoline loading rack provisions.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 11 2013-07-01 2013-07-01 false Gasoline loading rack provisions. 63...) National Emission Standards for Hazardous Air Pollutants From Petroleum Refineries § 63.650 Gasoline... or operator of a Group 1 gasoline loading rack classified under Standard Industrial Classification...

40 CFR 63.650 - Gasoline loading rack provisions.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 11 2014-07-01 2014-07-01 false Gasoline loading rack provisions. 63...) National Emission Standards for Hazardous Air Pollutants From Petroleum Refineries § 63.650 Gasoline... or operator of a Group 1 gasoline loading rack classified under Standard Industrial Classification...

40 CFR 65.166 - Periodic reports.

Code of Federal Regulations, 2010 CFR

2010-07-01

..., including a halogen reduction device for a low-throughput transfer rack, is used to control emissions from storage vessels or low-throughput transfer racks, the periodic report shall identify and state the cause...-throughput transfer racks, periodic reports shall include the following information: (1) Periodic reports...

Power Systems Integration Laboratory | Energy Systems Integration Facility

Science.gov Websites

inverters. Key Infrastructure Grid simulator, load bank, Opal-RT, battery, inverter mounting racks, data , frequency-watt, and grid anomaly ride-through. Key Infrastructure House power, Opal-RT, PV simulator access

sts128-s-047

NASA Image and Video Library

2009-09-14

STS128-S-047 (11 Sept. 2009) --- Space Shuttle Discovery?s main landing gear touches down at NASA's Dryden Flight Research Center at Edwards Air Force Base in California, concluding a successful mission to the International Space Station. Onboard are NASA astronauts Rick Sturckow, commander; Kevin Ford, pilot; John ?Danny? Olivas, Patrick Forrester, Jose Hernandez and Tim Kopra, all mission specialists; along with European Space Agency astronaut Christer Fuglesang, mission specialist. Discovery landed at 5:53 p.m. (PDT) on Sept. 11, 2009 to end the STS-128 mission, completing its almost 14-day journey of more than 5.7 million miles in space. The landing was diverted to California due to marginal weather at the Kennedy Space Center. Discovery?s mission featured three spacewalks and the delivery of two refrigerator-sized science racks to the space station. One rack will be used to conduct experiments on materials such as metals, glasses and ceramics. The results from these experiments could lead to the development of better materials on Earth. The other rack will be used for fluid physics research. Understanding how fluids react in microgravity could lead to improved designs for fuel tanks, water systems and other fluid-based systems.

sts128-s-045

NASA Image and Video Library

2009-09-11

STS128-S-045 (11 Sept. 2009) --- Space Shuttle Discovery?s main landing gear touches down at NASA's Dryden Flight Research Center at Edwards Air Force Base in California, concluding a successful mission to the International Space Station. Onboard are NASA astronauts Rick Sturckow, commander; Kevin Ford, pilot; John ?Danny? Olivas, Patrick Forrester, Jose Hernandez and Tim Kopra, all mission specialists; along with European Space Agency astronaut Christer Fuglesang, mission specialist. Discovery landed at 5:53 p.m. (PDT) on Sept. 11, 2009 to end the STS-128 mission, completing its almost 14-day journey of more than 5.7 million miles in space. The landing was diverted to California due to marginal weather at the Kennedy Space Center. Discovery?s mission featured three spacewalks and the delivery of two refrigerator-sized science racks to the space station. One rack will be used to conduct experiments on materials such as metals, glasses and ceramics. The results from these experiments could lead to the development of better materials on Earth. The other rack will be used for fluid physics research. Understanding how fluids react in microgravity could lead to improved designs for fuel tanks, water systems and other fluid-based systems.

sts128-s-048

NASA Image and Video Library

2009-09-11

STS128-S-048 (11 Sept. 2009) --- With its drag chute deployed, Space Shuttle Discovery slows to a stop after landing at NASA's Dryden Flight Research Center at Edwards Air Force Base in California, concluding a successful mission to the International Space Station. Onboard are NASA astronauts Rick Sturckow, commander; Kevin Ford, pilot; John ?Danny? Olivas, Patrick Forrester, Jose Hernandez and Tim Kopra, all mission specialists; along with European Space Agency astronaut Christer Fuglesang, mission specialist. Discovery landed at 5:53 p.m. (PDT) on Sept. 11, 2009 to end the STS-128 mission, completing its almost 14-day journey of more than 5.7 million miles in space. The landing was diverted to California due to marginal weather at the Kennedy Space Center. Discovery?s mission featured three spacewalks and the delivery of two refrigerator-sized science racks to the space station. One rack will be used to conduct experiments on materials such as metals, glasses and ceramics. The results from these experiments could lead to the development of better materials on Earth. The other rack will be used for fluid physics research. Understanding how fluids react in microgravity could lead to improved designs for fuel tanks, water systems and other fluid-based systems.

sts128-s-046

NASA Image and Video Library

2009-09-11

STS128-S-046 (11 Sept. 2009) --- Space Shuttle Discovery?s main landing gear touches down at NASA's Dryden Flight Research Center at Edwards Air Force Base in California, concluding a successful mission to the International Space Station. Onboard are NASA astronauts Rick Sturckow, commander; Kevin Ford, pilot; John ?Danny? Olivas, Patrick Forrester, Jose Hernandez and Tim Kopra, all mission specialists; along with European Space Agency astronaut Christer Fuglesang, mission specialist. Discovery landed at 5:53 p.m. (PDT) on Sept. 11, 2009 to end the STS-128 mission, completing its almost 14-day journey of more than 5.7 million miles in space. The landing was diverted to California due to marginal weather at the Kennedy Space Center. Discovery?s mission featured three spacewalks and the delivery of two refrigerator-sized science racks to the space station. One rack will be used to conduct experiments on materials such as metals, glasses and ceramics. The results from these experiments could lead to the development of better materials on Earth. The other rack will be used for fluid physics research. Understanding how fluids react in microgravity could lead to improved designs for fuel tanks, water systems and other fluid-based systems.

Implementation of a Water Flow Control System into the ISS'S Planned Fluids & Combustion Facility

NASA Technical Reports Server (NTRS)

Edwards, Daryl A.

2003-01-01

The Fluids and Combustion Facility (FCF) will become an ISS facility capable of performing basic combustion and fluids research. The facility consists of two independent payload racks specifically configured to support multiple experiments over the life of the ISS. Both racks will depend upon the ISS's Moderate Temperature Loop (MTL) for removing waste heat generated by the avionics and experiments operating within the racks. By using the MTL, constraints are imposed by the ISS vehicle on how the coolant resource is used. On the other hand, the FCF depends upon effective thermal control for maximizing life of the hardware and for supplying proper boundary conditions for the experiments. In the implementation of a design solution, significant factors in the selection of the hardware included ability to measure and control relatively low flow rates, ability to throttle flow within the time constraints of the ISS MTL, conserve energy usage, observe low mass and small volume requirements. An additional factor in the final design solution selection was considering how the system would respond to a loss of power event. This paper describes the method selected to satisfy the FCF design requirements while maintaining the constraints applied by the ISS vehicle.

41. Upper level, electronic racks, left to rightprogrammer group, status ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

41. Upper level, electronic racks, left to right--programmer group, status command message processing group, UHF radio, impss rack security - Ellsworth Air Force Base, Delta Flight, Launch Facility, On County Road T512, south of Exit 116 off I-90, Interior, Jackson County, SD

10 CFR 36.35 - Source rack protection.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 10 Energy 1 2011-01-01 2011-01-01 false Source rack protection. 36.35 Section 36.35 Energy NUCLEAR REGULATORY COMMISSION LICENSES AND RADIATION SAFETY REQUIREMENTS FOR IRRADIATORS Design and Performance... guides to prevent products and product carriers from hitting or touching the rack or mechanism. ...

16 CFR Figure 3 to Part 1610 - Specimen Holder Supported in Specimen Rack

Code of Federal Regulations, 2010 CFR

2010-01-01

... 16 Commercial Practices 2 2010-01-01 2010-01-01 false Specimen Holder Supported in Specimen Rack 3 Figure 3 to Part 1610 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION FLAMMABLE FABRICS ACT... Holder Supported in Specimen Rack ER25MR08.002 ...

Implementation of an Intelligent Control System

DTIC Science & Technology

1992-05-01

there- fore implemented in a portable equipment rack. The controls computer consists of a microcomputer running a real time operating system , interface...circuit boards are mounted in an industry standard Multibus I chassis. The microcomputer runs the iRMX real time operating system . This operating system

Design, modeling, and analysis of a feedstock logistics system.

PubMed

Judd, Jason D; Sarin, Subhash C; Cundiff, John S

2012-01-01

Given the location of a bio-energy plant for the conversion of biomass to bio-energy, a feedstock logistics system that relies on the use of satellite storage locations (SSLs) for temporary storage and loading of round bales is proposed. Three equipment systems are considered for handling biomass at the SSLs, and they are either placed permanently or are mobile and thereby travel from one SSL to another. A mathematical programming-based approach is utilized to determine SSLs and equipment routes in order to minimize the total cost. The use of a Side-loading Rack System results in average savings of 21.3% over a Densification System while a Rear-loading Rack System is more expensive to operate than either of the other equipment systems. The utilization of mobile equipment results in average savings of 14.8% over the equipment placed permanently. Furthermore, the Densification System is not justifiable for transportation distances less than 81 km. Copyright © 2011 Elsevier Ltd. All rights reserved.

Acetylcholinesterase-R increases germ cell apoptosis but enhances sperm motility

PubMed Central

Mor, I; Sklan, EH; Podoly, E; Pick, M; Kirschner, M; Yogev, L; Bar-Sheshet Itach, S; Schreiber, L; Geyer, B; Mor, T; Grisaru, D; Soreq, H

2008-01-01

Abstract Changes in protein subdomains through alternative splicing often modify protein-protein interactions, altering biological processes. A relevant example is that of the stress-induced up-regulation of the acetylcholinesterase (AChE-R) splice variant, a common response in various tissues. In germ cells of male transgenic TgR mice, AChE-R excess associates with reduced sperm differentiation and sperm counts. To explore the mechanism(s) by which AChE-R up-regulation affects spermatogenesis, we identified AChE-R's protein partners through a yeast two-hybrid screen. In meiotic spermatocytes from TgR mice, we detected AChE-R interaction with the scaffold protein RACK1 and elevated apoptosis. This correlated with reduced scavenging by RACK1 of the pro-apoptotic TAp73, an outcome compatible with the increased apoptosis. In contrast, at later stages in sperm development, AChE-R's interaction with the glycolytic enzyme enolase-α elevates enolase activity. In transfected cells, enforced AChE-R excess increased glucose uptake and adenosine tri-phosphate (ATP) levels. Correspondingly, TgR sperm cells display elevated ATP levels, mitochondrial hyperactivity and increased motility. In human donors' sperm, we found direct association of sperm motility with AChE-R expression. Interchanging interactions with RACK1 and enolase-α may hence enable AChE-R to affect both sperm differentiation and function by participating in independent cellular pathways. PMID:18194455

KSC-04PD-2492

NASA Technical Reports Server (NTRS)

2004-01-01

KENNEDY SPACE CENTER, FLA. In the Space Station Processing Facility, Gaschen Geissen and Elton Witt, with Lockheed Martin, monitor the Payload Test and Checkout System for the Human Research Facility (HRF) Rack -2 payload. The HRF-2 is scheduled to fly on Return to Flight Space Shuttle mission STS-114. The HRF-2 will deliver additional biomedical instrumentation and research capability to the International Space Station. HRF Rack 1 contains an ultrasound unit and gas analyzer system and has been operational in the U.S. Lab since May 2001. HRF-2 will also be installed in the U. S. Lab and will provide structural, power, thermal, command and data handling, and communication and tracking interfaces between the HRF biomedical instrumentation and the U. S. Lab.

Environmental Exposure Effects on Composite Materials for Commercial Aircraft

NASA Technical Reports Server (NTRS)

Hoffman, D. J.

1981-01-01

This period's activities were highlighted by continued long term and accelerated lab exposure testing, and by completion of all fabrication tasks on the optional material systems, AS1/3501-6 and Kevlar 49/F161-188. Initial baseline testing was performed on the two optional material systems. Long term exposure specimens were returned from three of the four ground rack sites and from two of the three aircraft locations. Test data from specimens returned from Dryden after 2 years exposure do not indicate continuing trends of strength reduction from the 1 year data. Test data from specimens returned from the Wellington, new Zealand ground rack and on Air New Zealand aircraft after 1 year exposure show strength changes fairly typical of other locations.

42. Upper level, electronic racks, left to rightguidance and control ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

42. Upper level, electronic racks, left to right--guidance and control coupler rack, programmer group, status command message processing group, UHF radio - Ellsworth Air Force Base, Delta Flight, Launch Facility, On County Road T512, south of Exit 116 off I-90, Interior, Jackson County, SD

78 FR 28152 - Airworthiness Directives; Airbus Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-14

... series airplanes. The existing AD currently requires repetitive inspections of the 80VU rack lower lateral fittings for damage; repetitive inspections of the 80VU rack lower central support for cracking... fittings of the 80VU rack. This proposed AD would reduce the inspection compliance time, add an inspection...

40 CFR 65.80 - Applicability.

Code of Federal Regulations, 2010 CFR

2010-07-01

... FEDERAL AIR RULE Transfer Racks § 65.80 Applicability. (a) The provisions of this subpart and of subpart A of this part apply to control of regulated material emissions from transfer racks where a referencing... is made that causes a transfer rack to fall outside the criteria in the referencing subpart that...

1. EAST SIDE OF OVERHEAD BOMB TRANSPORT RACK, WITH BUILDING ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. EAST SIDE OF OVERHEAD BOMB TRANSPORT RACK, WITH BUILDING 343 AT LEFT AND BUILDING 328 AT RIGHT. VIEW TO WEST. - Rocky Mountain Arsenal, Overhead Bomb Transport Rack, 1580 feet South of December Seventh Avenue; 860 feet West of D Street, Commerce City, Adams County, CO

26. A typical outer rod room, or rack room, showing ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

26. A typical outer rod room, or rack room, showing the racks for the nine horizontal control rods (HCRs) that would be inserted or withdrawn from the pile to control the rate of reaction. In this case, it is the 105-F Reactor in February 1945. The view is looking away from the pile, which is out of the picture on the left. Several of the cooling water hose reels for the rods can be seen at the end of the racks near the wall. D-8323 - B Reactor, Richland, Benton County, WA

Integrated payload and mission planning, phase 3. Volume 4: Optimum utilization of Spacelab racks and pallets

NASA Technical Reports Server (NTRS)

Logston, R. G.; Budris, G. D.

1977-01-01

The methodology to optimize the utilization of Spacelab racks and pallets and to apply this methodology to the early STS Spacelab missions was developed. A review was made of Spacelab Program requirements and flow plans, generic flow plans for racks and pallets were examined, and the principal optimization criteria and methodology were established. Interactions between schedule, inventory, and key optimization factors; schedule and cost sensitivity to optional approaches; and the development of tradeoff methodology were addressed. This methodology was then applied to early spacelab missions (1980-1982). Rack and pallet requirements and duty cycles were defined, a utilization assessment was made, and several trade studies performed involving varying degrees of Level IV integration, inventory level, and shared versus dedicated Spacelab racks and pallets.

ASTP video tape recorder ground support equipment (audio/CTE splitter/interleaver). Operations manual

NASA Technical Reports Server (NTRS)

1974-01-01

A descriptive handbook for the audio/CTE splitter/interleaver (RCA part No. 8673734-502) was presented. This unit is designed to perform two major functions: extract audio and time data from an interleaved video/audio signal (splitter section), and provide a test interleaved video/audio/CTE signal for the system (interleaver section). It is a rack mounting unit 7 inches high, 19 inches wide, 20 inches deep, mounted on slides for retracting from the rack, and weighs approximately 40 pounds. The following information is provided: installation, operation, principles of operation, maintenance, schematics and parts lists.

Plasmonic rack-and-pinion gear with chiral metasurface

NASA Astrophysics Data System (ADS)

Gorodetski, Yuri; Karabchevsky, Alina

2016-04-01

The effect of circularly polarized beaming excited by traveling surface plasmons, via chiral metasurface is experimentally studied. Here we show that the propagation direction of the plasmonic wave, evanescently excited on the thin gold film affects the handedness of the scattered beam polarization. Nanostructured metasurface leads to excitation of localized plasmonic modes whose relative spatial orientation induces overall spin-orbit interaction. This effect is analogical to the rack-and-pinion gear: the rotational motion into the linear motion converter. From the practical point of view, the observed effect can be utilized in integrated optical circuits for communication systems, cyber security and sensing.

Next generation platforms for high-throughput biodosimetry

PubMed Central

Repin, Mikhail; Turner, Helen C.; Garty, Guy; Brenner, David J.

2014-01-01

Here the general concept of the combined use of plates and tubes in racks compatible with the American National Standards Institute/the Society for Laboratory Automation and Screening microplate formats as the next generation platforms for increasing the throughput of biodosimetry assays was described. These platforms can be used at different stages of biodosimetry assays starting from blood collection into microtubes organised in standardised racks and ending with the cytogenetic analysis of samples in standardised multiwell and multichannel plates. Robotically friendly platforms can be used for different biodosimetry assays in minimally equipped laboratories and on cost-effective automated universal biotech systems. PMID:24837249

Microgravity Emissions Laboratory Testing of the Light Microscopy Module Control Box Fan

NASA Technical Reports Server (NTRS)

McNelis, Anne M.; Samorezov, Sergey; Haecker, Anthony H.

2003-01-01

The Microgravity Emissions Laboratory (MEL) was developed at the NASA Glenn Research Center for the characterization, simulation, and verification of the International Space Station (ISS) microgravity environment. This Glenn lab was developed in support of the Fluids and Combustion Facility (FCF). The MEL is a six-degrees-of-freedom inertial measurement system that can characterize the inertial response forces (emissions) of components, subrack payloads, or rack-level payloads down to 10 7g. The inertial force output data generated from the steady-state or transient operations of the test article are used with finite element analysis, statistical energy analysis, and other analysis tools to predict the on-orbit environment at specific science or rack interface locations. Customers of the MEL have used benefits in isolation performance testing in defining available attenuation during the engineering hardware design phase of their experiment s development. The Light Microscopy Module (LMM) Control Box (LCB) fan was tested in the MEL in June and July of 2002. The LMM is planned as a remotely controllable on-orbit microscope subrack facility that will be accommodated in an FCF Fluids Integrated Rack on the ISS. The disturbances measured in the MEL test resulted from operation of the air-circulation fan within the LCB. The objectives of the testing were (1) to identify an isolator to be added to the LCB fan assembly to reduce fan-speed harmonics and (2) to identify the fan-disturbance forcing functions for use in rack-response analysis of the LMM and Fluids Integrated Rack facility. This report describes the MEL, the testing process, and the results from ground-based MEL LCB fan testing.

Serious complications in experiments in which UV doses are effected by using different lamp heights.

PubMed

Flint, Stephan D; Ryel, Ronald J; Hudelson, Timothy J; Caldwell, Martyn M

2009-10-06

Many experiments examining plant responses to enhanced ultraviolet-B radiation (280-315nm) simply compare an enhanced UV-B treatment with ambient UV-B (or no UV-B radiation in most greenhouse and controlled-environment studies). Some more detailed experiments utilize multiple levels of UV-B radiation. A number of different techniques have been used to adjust the UV dose. One common technique is to place racks of fluorescent UV-emitting lamps at different heights above the plant canopy. However, the lamps and associated support structure cast shadows on the plant bed below. We calculated one example of the sequence of shade intervals for two common heights of lamp racks and show the patterns and duration of shade which the plants receive is distributed differently over the course of the day for different heights of the lamp racks. We also conducted a greenhouse experiment with plants (canola, sunflower and maize) grown under unenergized lamp racks suspended at the same two heights above the canopy. Growth characteristics differed in unpredictable ways between plants grown under the two heights of lamp racks. These differences could enhance or obscure potential UV-B effects. Also, differences in leaf mass per unit foliage area, which were observed in this experiment, could contribute to differences in plant UV-B sensitivity. We recommend the use of other techniques for achieving multiple doses of UV-B radiation. These range from simple and inexpensive approaches (e.g., wrapping individual fluorescent tubes in layers of a neutral-density filter such as cheese cloth) to more technical and expensive alternatives (e.g., electronically modulated lamp control systems). These choices should be determined according to the goals of the particular experiment.

Burning Questions in Gravity-Dependent Combustion Science

NASA Technical Reports Server (NTRS)

Urban, David; Chiaramonte, Francis P.

2012-01-01

Building upon a long history of spaceflight and ground based research, NASA's Combustion Science program has accumulated a significant body of accomplishments on the ISS. Historically, NASAs low-gravity combustion research program has sought: to provide a more complete understanding of the fundamental controlling processes in combustion by identifying simpler one-dimensional systems to eliminate the complex interactions between the buoyant flow and the energy feedback to the reaction zone to provide realistic simulation of the fire risk in manned spacecraft and to enable practical simulation of the gravitational environment experienced by reacting systems in future spacecraft. Over the past two decades, low-gravity combustion research has focused primarily on increasing our understanding of fundamental combustion processes (e.g. droplet combustion, soot, flame spread, smoldering, and gas-jet flames). This research program was highly successful and was aided by synergistic programs in Europe and in Japan. Overall improvements were made in our ability to model droplet combustion in spray combustors (e.g. jet engines), predict flame spread, predict soot production, and detect and prevent spacecraft fires. These results provided a unique dataset that supports both an active research discipline and also spacecraft fire safety for current and future spacecraft. These experiments have been conducted using the Combustion Integrated Rack (CIR), the Microgravity Science Glovebox and the Express Rack. In this paper, we provide an overview of the earlier space shuttle experiments, the recent ISS combustion experiments in addition to the studies planned for the future. Experiments in combustion include topics such as droplet combustion, gaseous diffusion flames, solid fuels, premixed flame studies, fire safety, and super critical oxidation processes.

77 FR 21734 - Certain Kitchen Appliance Shelving and Racks From the People's Republic of China: Final Results...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-11

... DEPARTMENT OF COMMERCE International Trade Administration [A-570-941] Certain Kitchen Appliance... duty order on certain kitchen appliance shelving and racks from the People's Republic of China (``PRC... Certain Kitchen Appliance Shelving and Racks From the People's Republic of China: Preliminary Results of...

NanoRacks CubeSat Deployment

NASA Image and Video Library

2014-02-13

ISS038-E-046586 (13 Feb. 2014) --- A set of NanoRacks CubeSats is photographed by an Expedition 38 crew member after the deployment by the NanoRacks Launcher attached to the end of the Japanese robotic arm. The CubeSats program contains a variety of experiments such as Earth observations and advanced electronics testing.

NanoRacks CubeSat Deployment

NASA Image and Video Library

2014-02-13

ISS038-E-046579 (13 Feb. 2014) --- A set of NanoRacks CubeSats is photographed by an Expedition 38 crew member after the deployment by the NanoRacks Launcher attached to the end of the Japanese robotic arm. The CubeSats program contains a variety of experiments such as Earth observations and advanced electronics testing.

40 CFR 65.7 - Monitoring, recordkeeping, and reporting waivers and alternatives, and alternative work practice...

Code of Federal Regulations, 2012 CFR

2012-07-01

... monitoring or recordkeeping provisions of this part. For process vents and transfer racks, except low-throughput transfer racks, the provisions in paragraph (c) of this section shall govern the review and... low throughput transfer racks, owners and operators shall comply with the requirements of § 65.145(b...

40 CFR 65.7 - Monitoring, recordkeeping, and reporting waivers and alternatives, and alternative work practice...

Code of Federal Regulations, 2011 CFR

2011-07-01

... monitoring or recordkeeping provisions of this part. For process vents and transfer racks, except low-throughput transfer racks, the provisions in paragraph (c) of this section shall govern the review and... low throughput transfer racks, owners and operators shall comply with the requirements of § 65.145(b...

40 CFR 65.7 - Monitoring, recordkeeping, and reporting waivers and alternatives, and alternative work practice...

Code of Federal Regulations, 2013 CFR

2013-07-01

... monitoring or recordkeeping provisions of this part. For process vents and transfer racks, except low-throughput transfer racks, the provisions in paragraph (c) of this section shall govern the review and... low throughput transfer racks, owners and operators shall comply with the requirements of § 65.145(b...

40 CFR 65.7 - Monitoring, recordkeeping, and reporting waivers and alternatives, and alternative work practice...

Code of Federal Regulations, 2014 CFR

2014-07-01

... monitoring or recordkeeping provisions of this part. For process vents and transfer racks, except low-throughput transfer racks, the provisions in paragraph (c) of this section shall govern the review and... low throughput transfer racks, owners and operators shall comply with the requirements of § 65.145(b...

40 CFR 65.7 - Monitoring, recordkeeping, and reporting waivers and alternatives, and alternative work practice...

Code of Federal Regulations, 2010 CFR

2010-07-01

... monitoring or recordkeeping provisions of this part. For process vents and transfer racks, except low-throughput transfer racks, the provisions in paragraph (c) of this section shall govern the review and... low throughput transfer racks, owners and operators shall comply with the requirements of § 65.145(b...

40 CFR 65.145 - Nonflare control devices used to control emissions from storage vessels or low-throughput...

Code of Federal Regulations, 2010 CFR

2010-07-01

... control emissions from storage vessels or low-throughput transfer racks. 65.145 Section 65.145 Protection... racks. (a) Nonflare control device equipment and operating requirements. The owner or operator shall...-throughput transfer rack, so that the monitored parameters defined as required in paragraph (c) of this...

40 CFR 63.985 - Nonflare control devices used to control emissions from storage vessels and low throughput...

Code of Federal Regulations, 2010 CFR

2010-07-01

... control emissions from storage vessels and low throughput transfer racks. 63.985 Section 63.985 Protection... transfer racks. (a) Nonflare control device equipment and operating requirements. The owner or operator... subpart for storage vessels and transfer racks, documentation that those conditions exist is sufficient to...

77 FR 27029 - Certain Kitchen Shelving and Racks From the People's Republic of China: Extension of Time Limit...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-08

... DEPARTMENT OF COMMERCE International Trade Administration [C-570-942] Certain Kitchen Shelving and Racks From the People's Republic of China: Extension of Time Limit for Preliminary Results of... certain kitchen appliance shelving and racks from the People's Republic of China, covering the review...

40 CFR 63.2338 - What parts of my plant does this subpart cover?

Code of Federal Regulations, 2010 CFR

2010-07-01

... transfer racks at which organic liquids are loaded into or unloaded out of transport vehicles and/or...) Storage tanks storing organic liquids; (ii) Transfer racks loading or unloading organic liquids; (iii... and a transfer rack subject to this subpart; and (v) Pipelines that transfer organic liquids directly...

The Fluids And Combustion Facility Combustion Integrated Rack And The Multi-User Droplet Combustion Apparatus: Microgravity Combustion Science Using Modular Multi-User Hardware

NASA Technical Reports Server (NTRS)

OMalley, Terence F.; Myhre, Craig A.

2000-01-01

The Fluids and Combustion Facility (FCF) is a multi-rack payload planned for the International Space Station (ISS) that will enable the study of fluid physics and combustion science in a microgravity environment. The Combustion Integrated Rack (CIR) is one of two International Standard Payload Racks of the FCF and is being designed primarily to support combustion science experiments. The Multi-user Droplet Combustion Apparatus (MDCA) is a multi-user apparatus designed to accommodate four different droplet combustion science experiments and is the first payload for CIR. The CIR will function independently until the later launch of the Fluids Integrated Rack component of the FCF. This paper provides an overview of the capabilities and the development status of the CIR and MDCA.

KENNEDY SPACE CENTER, FLA. - In the Space Station Processing Facility, Center Director Roy Bridges (left), Program Manager of the International Space Station (ISS) Randy Brinkley (second from left) and STS-98 Commander Ken Cockrell (right) applaud the unveiling of the name "Destiny" for the U.S. Laboratory module. The lab, which is behnd them on a workstand, is scheduled to be launched on STS-98 on Space Shuttle Endeavour in early 2000. It will become the centerpiece of scientific research on the ISS. The Shuttle will spend six days docked to the Station while the laboratory is attached and three spacewalks are conducted to compete its assembly. The laboratory will be launched with five equipment racks aboard, which will provide essential functions for Station systems, including high data-rate communications, and maintain the Station's orientation using control gyroscopes launched earlier. Additional equipment and research racks will be installed in the laboratory on subsequent Shuttle flights.

NASA Image and Video Library

1998-12-01

KENNEDY SPACE CENTER, FLA. - In the Space Station Processing Facility, Center Director Roy Bridges (left), Program Manager of the International Space Station (ISS) Randy Brinkley (second from left) and STS-98 Commander Ken Cockrell (right) applaud the unveiling of the name "Destiny" for the U.S. Laboratory module. The lab, which is behnd them on a workstand, is scheduled to be launched on STS-98 on Space Shuttle Endeavour in early 2000. It will become the centerpiece of scientific research on the ISS. The Shuttle will spend six days docked to the Station while the laboratory is attached and three spacewalks are conducted to compete its assembly. The laboratory will be launched with five equipment racks aboard, which will provide essential functions for Station systems, including high data-rate communications, and maintain the Station's orientation using control gyroscopes launched earlier. Additional equipment and research racks will be installed in the laboratory on subsequent Shuttle flights.

RACK1 and the microRNA pathway: is it déjà-vu all over again?

PubMed

Speth, Corinna; Laubinger, Sascha

2014-01-01

MicroRNAs (miRNAs) control many aspects of development and adaption in plants and in animals by post-transcriptional control of mRNA stability and translatability. Over the last years numerous proteins have been identified in the miRNA pathway. The versatile scaffold protein RACK1 has been associated with efficient miRNA production and function in plants and metazoans. Here, we briefly summarize the differences of RACK1 function in the plant and animal miRNA pathways and discuss putative mechanisms and functional roles of RACK1 in miRNA biogenesis and action.

Fail-safe storage rack for irradiated fuel rod assemblies

DOEpatents

Lewis, D.R.

1993-03-23

A fail-safe storage rack is provided for interim storage of spent but radioactive nuclear fuel rod assemblies. The rack consists of a checkerboard array of substantially square, elongate receiving tubes fully enclosed by a double walled container, the outer wall of which is imperforate for liquid containment and the inner wall of which is provided with perforations for admitting moderator liquid flow to the elongate receiving tubes, the liquid serving to take up waste heat from the stored nuclear assemblies and dissipate same to the ambient liquid reservoir. A perforated cover sealing the rack facilitates cooling liquid entry and dissipation.

Fail-safe storage rack for irradiated fuel rod assemblies

DOEpatents

Lewis, Donald R.

1993-01-01

A fail-safe storage rack is provided for interim storage of spent but radioactive nuclear fuel rod assemblies. The rack consists of a checkerboard array of substantially square, elongate receiving tubes fully enclosed by a double walled container, the outer wall of which is imperforate for liquid containment and the inner wall of which is provided with perforations for admitting moderator liquid flow to the elongate receiving tubes, the liquid serving to take up waste heat from the stored nuclear assemblies and dissipate same to the ambient liquid reservoir. A perforated cover sealing the rack facilitates cooling liquid entry and dissipation.

The Fastrack Suborbital Platform for Microgravity Applications

NASA Technical Reports Server (NTRS)

Levine, H. G.; Ball, J. E.; Shultz, D.; Odyssey, A.; Wells, H. W.; Soler, R. R.; Albino, S.; Meshberger, R. J.; Murdoch, T.

2009-01-01

The FASTRACK suborbital experiment platform has been developed to provide a capability for utilizing 2.5-5 minute microgravity flight opportunities anticipated from the commercial suborbital fleet (currently in development) for science investigations, technology development and hardware testing. It also provides "express rack" functionality to deliver payloads to ISS. FASTRACK fits within a 24" x 24" x 36" (61 cm x 61 cm x 91.4 cm) envelope and is capable of supporting either two single Middeck Locker Equivalents (MLE) or one double MLE configuration. Its overall mass is 300 lbs (136 kg), of which 160 lbs (72 kg) is reserved for experiments. FASTRACK operates using 28 VDC power or batteries. A support drawer located at the bottom of the structure contains all ancillary electrical equipment (including batteries, a conditioned power system and a data collection system) as well as a front panel that contains all switches (including remote cut-off), breakers and warning LEDs.

40 CFR 63.2342 - When do I have to comply with this subpart?

Code of Federal Regulations, 2014 CFR

2014-07-01

... operator must comply with the transfer rack requirements specified in § 63.2346(b) immediately; that is, be... transfer rack requirements specified in § 63.2346(b) immediately; that is, be in compliance the first day... owner or operator believes that compliance with the transfer rack emission limits cannot be achieved...

40 CFR 63.2342 - When do I have to comply with this subpart?

Code of Federal Regulations, 2010 CFR

2010-07-01

... operator must comply with the transfer rack requirements specified in § 63.2346(b) immediately; that is, be... transfer rack requirements specified in § 63.2346(b) immediately; that is, be in compliance the first day... owner or operator believes that compliance with the transfer rack emission limits cannot be achieved...

40 CFR 63.2342 - When do I have to comply with this subpart?

Code of Federal Regulations, 2011 CFR

2011-07-01

... operator must comply with the transfer rack requirements specified in § 63.2346(b) immediately; that is, be... transfer rack requirements specified in § 63.2346(b) immediately; that is, be in compliance the first day... owner or operator believes that compliance with the transfer rack emission limits cannot be achieved...

40 CFR 63.2358 - By what date must I conduct performance tests and other initial compliance demonstrations?

Code of Federal Regulations, 2010 CFR

2010-07-01

... racks at existing affected sources complying with the emission limitations listed in Table 2 to this... storage tanks and transfer racks at reconstructed or new affected sources complying with the emission... section, you must comply within 180 days after April 25, 2011. (2) For transfer racks and equipment leak...

40 CFR Table 3 to Subpart Eeee of... - Operating Limits-High Throughput Transfer Racks

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 12 2010-07-01 2010-07-01 true Operating Limits-High Throughput Transfer Racks 3 Table 3 to Subpart EEEE of Part 63 Protection of Environment ENVIRONMENTAL PROTECTION... Throughput Transfer Racks As stated in § 63.2346(e), you must comply with the operating limits for existing...

40 CFR 63.2343 - What are my requirements for emission sources not requiring control?

Code of Federal Regulations, 2010 CFR

2010-07-01

... of less than 18.9 cubic meters (5,000 gallons) and for each transfer rack subject to this subpart that only unloads organic liquids (i.e., no organic liquids are loaded at any of the transfer racks), you must keep documentation that verifies that each storage tank and transfer rack identified in...

Float Package and the Data Rack aboard the DC-9

NASA Technical Reports Server (NTRS)

1996-01-01

Ted Brunzie and Peter Mason observe the float package and the data rack aboard the DC-9 reduced gravity aircraft. The float package contains a cryostat, a video camera, a pump and accelerometers. The data rack displays and record the video signal from the float package on tape and stores acceleration and temperature measurements on disk.

UAH/NASA Workshop on Fluids Experiment System

NASA Technical Reports Server (NTRS)

Hendricks, J. (Editor); Askins, B. (Editor)

1979-01-01

The Fluids Experiment System is being developed to fit into a Spacelab rack. Papers presented at this workshop describe a variety of fluid and chemical experiments that would be of great benefit to researchers of processes in a low gravity environment.

Asetek's Warm-Water Liquid Cooling System Yields Energy Cost Savings at

Science.gov Websites

NREL | Energy Systems Integration Facility | NREL Asetek Asetek's Warm-Water Liquid Cooling System Yields Energy Cost Savings at NREL Asetek's RackCDU liquid cooling system was installed and tested at the Energy Systems Integration Facility's (ESIF's) ultra-energy-efficient high-performance

Reload of an industrial cylindrical cobalt source rack

NASA Astrophysics Data System (ADS)

Gharbi, F.; Kadri, O.; Trabelsi, A.

2006-10-01

This work presents a Monte Carlo study of the cylindrical cobalt source rack geometry of the Tunisian gamma irradiation facility, using the GEANT code developed at CERN. The study investigates the question of the reload of the source rack. The studied configurations consist in housing four new cobalt pencils, two in the upper and two in the lower cylinder of the source rack. Global dose rate uniformity inside a "dummy" product for the case of routine and nonroutine irradiation, and as function of the product bulk density, was calculated for eight hypothetical configurations. The same calculation was also performed for both of the original and the ideal (but not practical) configurations. It was shown that hypothetical cases produced dose uniformity variations, according to product density, that were statistically no different than the original and the ideal configurations and that the reload procedure cannot improve the irradiation quality inside the facilities using cylindrical cobalt source racks.

Rack assembly for mounting solar modules

DOEpatents

Plaisted, Joshua Reed; West, Brian

2010-12-28

A rack assembly is provided for mounting solar modules over an underlying body. The rack assembly may include a plurality of rail structures that are arrangeable over the underlying body to form an overall perimeter for the rack assembly. One or more retention structures may be provided with the plurality of rail structures, where each retention structure is configured to support one or more solar modules at a given height above the underlying body. At least some of the plurality of rail structures are adapted to enable individual rail structures o be sealed over the underlying body so as to constrain air flow underneath the solar modules. Additionally, at least one of (i) one or more of the rail structures, or (ii) the one or more retention structures are adjustable so as to adapt the rack assembly to accommodate solar modules of varying forms or dimensions.

Rack assembly for mounting solar modules

DOEpatents

Plaisted, Joshua Reed; West, Brian

2012-09-04

A rack assembly is provided for mounting solar modules over an underlying body. The rack assembly may include a plurality of rail structures that are arrangeable over the underlying body to form an overall perimeter for the rack assembly. One or more retention structures may be provided with the plurality of rail structures, where each retention structure is configured to support one or more solar modules at a given height above the underlying body. At least some of the plurality of rail structures are adapted to enable individual rail structures to be sealed over the underlying body so as to constrain air flow underneath the solar modules. Additionally, at least one of (i) one or more of the rail structures, or (ii) the one or more retention structures are adjustable so as to adapt the rack assembly to accommodate solar modules of varying forms or dimensions.

Rack assembly for mounting solar modules

DOEpatents

Plaisted, Joshua Reed; West, Brian

2014-06-10

A rack assembly is provided for mounting solar modules over an underlying body. The rack assembly may include a plurality of rail structures that are arrangeable over the underlying body to form an overall perimeter for the rack assembly. One or more retention structures may be provided with the plurality of rail structures, where each retention structure is configured to support one or more solar modules at a given height above the underlying body. At least some of the plurality of rail structures are adapted to enable individual rail structures o be sealed over the underlying body so as to constrain air flow underneath the solar modules. Additionally, at least one of (i) one or more of the rail structures, or (ii) the one or more retention structures are adjustable so as to adapt the rack assembly to accommodate solar modules of varying forms or dimensions.

Test Rack Development for Extended Operation of Advanced Stirling Convertors at NASA Glenn Research Center

NASA Technical Reports Server (NTRS)

Dugala, Gina M.

2009-01-01

The U.S. Department of Energy (DOE), Lockheed Martin Space Company (LMSC), Sun power Inc., and NASA Glenn Research Center (GRC) have been developing an Advanced Stirling Radioisotope Generator (ASRG) for use as a power system on space science missions. This generator will make use of free-piston Stirling convertors to achieve higher conversion efficiency than currently available alternatives. NASA GRC's support of ASRG development includes extended operation testing of Advanced Stirling Convertors (ASCs) developed by Sunpower Inc. In the past year, NASA GRC has been building a test facility to support extended operation of a pair of engineering level ASCs. Operation of the convertors in the test facility provides convertor performance data over an extended period of time. Mechanical support hardware, data acquisition software, and an instrumentation rack were developed to prepare the pair of convertors for continuous extended operation. Short-term tests were performed to gather baseline performance data before extended operation was initiated. These tests included workmanship vibration, insulation thermal loss characterization, low-temperature checkout, and fUll-power operation. Hardware and software features are implemented to ensure reliability of support systems. This paper discusses the mechanical support hardware, instrumentation rack, data acquisition software, short-term tests, and safety features designed to support continuous unattended operation of a pair of ASCs.

40 CFR 63.11088 - What requirements must I meet for gasoline loading racks if my facility is a bulk gasoline...

Code of Federal Regulations, 2014 CFR

2014-07-01

... gasoline loading racks if my facility is a bulk gasoline terminal, pipeline breakout station, or pipeline... CATEGORIES (CONTINUED) National Emission Standards for Hazardous Air Pollutants for Source Category: Gasoline... § 63.11088 What requirements must I meet for gasoline loading racks if my facility is a bulk gasoline...

40 CFR 63.11088 - What requirements must I meet for gasoline loading racks if my facility is a bulk gasoline...

Code of Federal Regulations, 2010 CFR

2010-07-01

... gasoline loading racks if my facility is a bulk gasoline terminal, pipeline breakout station, or pipeline... CATEGORIES (CONTINUED) National Emission Standards for Hazardous Air Pollutants for Source Category: Gasoline... § 63.11088 What requirements must I meet for gasoline loading racks if my facility is a bulk gasoline...

40 CFR 63.11088 - What requirements must I meet for gasoline loading racks if my facility is a bulk gasoline...

Code of Federal Regulations, 2013 CFR

2013-07-01

... gasoline loading racks if my facility is a bulk gasoline terminal, pipeline breakout station, or pipeline... CATEGORIES (CONTINUED) National Emission Standards for Hazardous Air Pollutants for Source Category: Gasoline... § 63.11088 What requirements must I meet for gasoline loading racks if my facility is a bulk gasoline...

40 CFR 63.11088 - What requirements must I meet for gasoline loading racks if my facility is a bulk gasoline...

Code of Federal Regulations, 2011 CFR

2011-07-01

... gasoline loading racks if my facility is a bulk gasoline terminal, pipeline breakout station, or pipeline... CATEGORIES (CONTINUED) National Emission Standards for Hazardous Air Pollutants for Source Category: Gasoline... § 63.11088 What requirements must I meet for gasoline loading racks if my facility is a bulk gasoline...

40 CFR 63.11088 - What requirements must I meet for gasoline loading racks if my facility is a bulk gasoline...

Code of Federal Regulations, 2012 CFR

2012-07-01

... gasoline loading racks if my facility is a bulk gasoline terminal, pipeline breakout station, or pipeline... CATEGORIES (CONTINUED) National Emission Standards for Hazardous Air Pollutants for Source Category: Gasoline... § 63.11088 What requirements must I meet for gasoline loading racks if my facility is a bulk gasoline...

76 FR 15295 - Floor-Standing, Metal-Top Ironing Tables and Certain Parts Thereof From the People's Republic of...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-21

... rests, linen racks, and others. The subject ironing tables may be sold with or without a pad and/or... an included feature such as an iron rest or linen rack. The term ``complete'' ironing table means... without additional features, e.g., iron rest or linen rack. The term ``incomplete'' ironing table means...

40 CFR 63.130 - Transfer operations provisions-periodic recordkeeping and reporting.

Code of Federal Regulations, 2010 CFR

2010-07-01

... from the control device is used, each owner or operator of a Group 1 transfer rack subject to the... of a Group 1 transfer rack who uses a flare to comply with § 63.126(b)(2) of this subpart shall keep...)(2) of this subpart. (d) Each owner or operator of a transfer rack subject to the requirements of...

75 FR 46873 - Airworthiness Directives; Airbus Model A318-111 and A318-112 Airplanes and Model A319, A320, and...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-04

... fittings of the 80VU rack, typically elongated holes, migrated bushes [bushings], and/or missing bolts have... with a high load factor or strong vibration could lead to failure of the rack structure and/or... rack contains computers for Flight Controls, Communication and Radio-navigation. These functions are...

75 FR 3201 - Floor-Standing, Metal-Top Ironing Tables and Certain Parts Thereof From the People's Republic of...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-20

... available with various features, including iron rests, linen racks, and others. The subject ironing tables... linen rack. The term ``complete'' ironing table means product sold as a ready-to-use ensemble consisting... linen rack. The term ``incomplete'' ironing table means product shipped or sold as a ``bare board''--i.e...

77 FR 55806 - Floor-Standing, Metal-Top Ironing Tables and Certain Parts Thereof From the People's Republic of...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-09-11

... rests, linen racks, and others. The subject ironing tables may be sold with or without a pad and/or... an included feature such as an iron rest or linen rack. The term ``complete'' ironing table means... without additional features, e.g., iron rest or linen rack. The term ``incomplete'' ironing table means...

75 FR 36629 - Floor-Standing, Metal-Top Ironing Tables and Certain Parts Thereof from the People's Republic of...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-28

... various features, including iron rests, linen racks, and others. The subject ironing tables may be sold... top or the attachment of an included feature such as an iron rest or linen rack. The term ``complete... and cover, with or without additional features, e.g., iron rest or linen rack. The term ``incomplete...

Effect of Channel Catfish Ictalurus Punctatus Egg Mass Loading Rate on Performance of the “See-Saw” Incubator

USDA-ARS?s Scientific Manuscript database

The “See-Saw” is a vertical-lift incubator that increases water circulation around and through channel catfish egg masses. Baskets in the incubator move up and down on racks in conventional hatchery troughs, raising the rack in one trough while lowering the rack in the adjacent trough. Egg masses ...

40 CFR Table 9 to Subpart Eeee of... - Continuous Compliance With Operating Limits-High Throughput Transfer Racks

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 12 2010-07-01 2010-07-01 true Continuous Compliance With Operating Limits-High Throughput Transfer Racks 9 Table 9 to Subpart EEEE of Part 63 Protection of Environment...—Continuous Compliance With Operating Limits—High Throughput Transfer Racks As stated in §§ 63.2378(a) and (b...

77 FR 14499 - Floor-Standing, Metal-Top Ironing Tables and Certain Parts Thereof From the People's Republic of...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-12

... various features, including iron rests, linen racks, and others. The subject ironing tables may be sold... top or the attachment of an included feature such as an iron rest or linen rack. The term ``complete... and cover, with or without additional features, e.g., iron rest or linen rack. The term ``incomplete...

76 FR 15297 - Floor-Standing, Metal-Top Ironing Tables and Certain Parts Thereof From the People's Republic of...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-21

... rests, linen racks, and others. The subject ironing tables may be sold with or without a pad and/or... an included feature such as an iron rest or linen rack. The term ``complete'' ironing table means... without additional features, e.g., iron rest or linen rack. The term ``incomplete'' ironing table means...

75 FR 28475 - Airworthiness Directives; Airbus Model A330-200 and -300 Series Airplanes, and Model A340-300...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-21

... unsafe condition as: In the door 2 area, the hat-racks are supplied with a basic wire harness which includes ``Oxygen Masks'' activation. In case of a monument installation, the respective non-used hat- rack... door 2 area, the hat-racks are supplied with a basic wire harness which includes ``Oxygen Masks...

95. VIEW OF SOUTHWEST CORNER OF LANDLINE INSTRUMENTATION ROOM (106), ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

95. VIEW OF SOUTHWEST CORNER OF LANDLINE INSTRUMENTATION ROOM (106), LSB (BLDG. 770). BATTERY RACK FOR BACKUP BOOSTER POWER ON LEFT; BATTERY RACK FOR BACKUP AEROSPACE GROUND EQUIPMENT (AGE) POWER ON RIGHT. BATTERY CHARGER IS RIGHT OF BATTERY RACKS. - Vandenberg Air Force Base, Space Launch Complex 3, Launch Pad 3 West, Napa & Alden Roads, Lompoc, Santa Barbara County, CA

Laboratory racks are installed in the MPLM Leonardo

NASA Technical Reports Server (NTRS)

2000-01-01

In the Space Station Processing Facility, another laboratory rack is placed on the arm of the Rack Insertion Unit to lift it to the workstand height of the Multi-Purpose Logistics Module Leonardo (not seen). The MPLM will transport laboratory racks filled with equipment, experiments and supplies to and from the International Space Station aboard the Space Shuttle. Leonardo will be launched for the first time March 1, 2001, on Shuttle mission STS-102. On that flight, Leonardo will be filled with equipment and supplies to outfit the U.S. laboratory module, being carried to the ISS on the Jan. 19, 2001, launch of STS-98.

Benchmarking criticality analysis of TRIGA fuel storage racks.

PubMed

Robinson, Matthew Loren; DeBey, Timothy M; Higginbotham, Jack F

2017-01-01

A criticality analysis was benchmarked to sub-criticality measurements of the hexagonal fuel storage racks at the United States Geological Survey TRIGA MARK I reactor in Denver. These racks, which hold up to 19 fuel elements each, are arranged at 0.61m (2 feet) spacings around the outer edge of the reactor. A 3-dimensional model was created of the racks using MCNP5, and the model was verified experimentally by comparison to measured subcritical multiplication data collected in an approach to critical loading of two of the racks. The validated model was then used to show that in the extreme condition where the entire circumference of the pool was lined with racks loaded with used fuel the storage array is subcritical with a k value of about 0.71; well below the regulatory limit of 0.8. A model was also constructed of the rectangular 2×10 fuel storage array used in many other TRIGA reactors to validate the technique against the original TRIGA licensing sub-critical analysis performed in 1966. The fuel used in this study was standard 20% enriched (LEU) aluminum or stainless steel clad TRIGA fuel. Copyright © 2016. Published by Elsevier Ltd.

Effect of large wood retention at check dams on sediment continuity

NASA Astrophysics Data System (ADS)

Schmocker, Lukas; Schalko, Isabella; Weitbrecht, Volker

2017-04-01

Large wood transport during flood events may seriously increase the damage potential due to accumulations at river infrastructures. The large wood is therefore mostly retained upstream of populated areas using retention structures that often combine a check dam with a debris rack. One disadvantages of this structures is, that the bed-load gets retained along with the wood. Especially if large wood blocks the rack early during a flood event, sediment continuity is completely interrupted. This may lead to severe bed erosion downstream of the check dam. So far, no common design to retain large wood but maintain sediment continuity is available. One attempt to separate the large wood from the bed-load was made with the large wood retention structure at River Sihl in Zürich, Switzerland. The retention of the large wood occurs in a bypass channel located along the main river. The bypass is located at an outer river bend, where a separation of bed-load and large wood results due to the secondary currents induced by the river curvature. Large wood floats towards the outer bend due to inertia and the secondary currents whereas bed-load remains at the inner bend. The bypass is separated by a side weir from the main river to ensure that the bed-load remains in the river during bed forming discharges and flood events. New model test are currently carried out at the Laboratory of Hydraulics, Hydrology, and Glaciology (VAW) of ETH Zurich, where sediment continuity should be achieved using an inclined rack. The rack is inclined in flow direction with a degree of 45° to 20°. First results show that the large wood deposits at the upper part of the rack whereas the lower part of the rack remains free for bed-load transport. Furthermore, the backwater rise for the inclined rack due to the accumulated wood is considerably reduced compared to a vertical rack, as a large part of the rack remains clear for the flow to pass. The findings of this studies help to understand the complex interaction between sediment and large wood at a check dam retention structure. Furthermore, new retention structures and rack designs are available, where sediment continuity can partially be maintained to reduce downstream bed erosion.

AMO EXPRESS: A Command and Control Experiment for Crew Autonomy Onboard the International Space Station

NASA Technical Reports Server (NTRS)

Stetson, Howard K.; Haddock, Angie T.; Frank, Jeremy; Cornelius, Randy; Wang, Lui; Garner, Larry

2015-01-01

NASA is investigating a range of future human spaceflight missions, including both Mars-distance and Near Earth Object (NEO) targets. Of significant importance for these missions is the balance between crew autonomy and vehicle automation. As distance from Earth results in increasing communication delays, future crews need both the capability and authority to independently make decisions. However, small crews cannot take on all functions performed by ground today, and so vehicles must be more automated to reduce the crew workload for such missions. NASA's Advanced Exploration Systems Program funded Autonomous Mission Operations (AMO) project conducted an autonomous command and control experiment on-board the International Space Station that demonstrated single action intelligent procedures for crew command and control. The target problem was to enable crew initialization of a facility class rack with power and thermal interfaces, and involving core and payload command and telemetry processing, without support from ground controllers. This autonomous operations capability is enabling in scenarios such as initialization of a medical facility to respond to a crew medical emergency, and representative of other spacecraft autonomy challenges. The experiment was conducted using the Expedite the Processing of Experiments for Space Station (EXPRESS) rack 7, which was located in the Port 2 location within the U.S Laboratory onboard the International Space Station (ISS). Activation and deactivation of this facility is time consuming and operationally intensive, requiring coordination of three flight control positions, 47 nominal steps, 57 commands, 276 telemetry checks, and coordination of multiple ISS systems (both core and payload). Utilization of Draper Laboratory's Timeliner software, deployed on-board the ISS within the Command and Control (C&C) computers and the Payload computers, allowed development of the automated procedures specific to ISS without having to certify and employ novel software for procedure development and execution. The procedures contained the ground procedure logic and actions as possible to include fault detection and recovery capabilities. The autonomous operations concept includes a reduction of the amount of data a crew operator is required to verify during activation or de-activation, as well as integration of procedure execution status and relevant data in a single integrated display. During execution, the auto-procedures (via Timerliner) provide a step-by-step messaging paradigm and a high-level status upon termination. This messaging and high-level status is the only data generated for operator display. To enhance situational awareness of the operator, the Web-based Procedure Display (WebPD) provides a novel approach to the issues of procedure display and execution tracking. WebPD is a web based application that serves as the user interface for electronic procedure execution. It incorporates several aspects of the HTML5 standard. Procedures are written in a dialect of XML called Procedure Representation Language (PRL). WebPD tracks execution status in the procedure or procedures being displayed. WebPD aggregates and simplifies the auto-sequence execution status information, and formatted to be easily followed and understood by an operator who is not dedicated to actively monitoring the task. WebPD also provides an integrated data and control interface to pause or halt the execution in order to provide a check point of operation and to examine progress before starting the next sequence of activities. For this demonstration, the procedure was initiated and monitored from the ground. As the Timeliner sequences executed, their high-level execution status was written to PLMDM memory. This memory is read and downlinked via Ku-Band at a 1 Hz rate. The data containing the high-level execution status is de-commutated on the ground, and rebroadcast for WebPD consumption. A future demonstration will be performed onboard, with ISS astronauts initiating the operations instead of ground controllers. The AMO EXPRESS experiment demonstrated activation and de-activation of EXPRESS rack 7, providing the capability of future single button activations and deactivations of facility class racks. The experiment achieved numerous technical and operations 'firsts' for the ISS

NanoRacks CubeSat

NASA Image and Video Library

2014-02-14

ISS038-E-047232 (14 Feb. 2014) --- A set of NanoRacks CubeSats is photographed by an Expedition 38 crew member after the deployment by the NanoRacks Launcher attached to the end of the Japanese robotic arm. The CubeSats program contains a variety of experiments such as Earth observations and advanced electronics testing. International Space Station solar array panels provide the backdrop for the scene.

Physics of Colloids in Space: Microgravity Experiment Launched, Installed, and Activated on the International Space Station

NASA Technical Reports Server (NTRS)

Doherty, Michael P.

2002-01-01

The Physics of Colloids in Space (PCS) experiment is a Microgravity Fluids Physics investigation that is presently located in an Expedite the Process of Experiments to Space Station (EXPRESS) Rack on the International Space Station. PCS was launched to the International Space Station on April 19, 2001, activated on May 31, 2001, and will continue to operate about 90 hr per week through May 2002.

Automation of Space Station module power management and distribution system

NASA Technical Reports Server (NTRS)

Bechtel, Robert; Weeks, Dave; Walls, Bryan

1990-01-01

Viewgraphs on automation of space station module (SSM) power management and distribution (PMAD) system are presented. Topics covered include: reasons for power system automation; SSM/PMAD approach to automation; SSM/PMAD test bed; SSM/PMAD topology; functional partitioning; SSM/PMAD control; rack level autonomy; FRAMES AI system; and future technology needs for power system automation.

AN INTERNET RACK MONITOR-CONTROLLER FOR APS LINAC RF ELECTRONICS UPGRADE

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ma, Hengjie; Smith, Terry; Nassiri, Alireza

To support the research and development in APS LINAC area, the existing LINAC rf control performance needs to be much improved, and thus an upgrade of the legacy LINAC rf electronics becomes necessary. The proposed upgrade plan centers on the concept of using a modern, network-attached, rackmount digital electronics platform –Internet Rack Monitor-Controller (or IRMC) to achieve the goal of modernizing the rf electronics at a lower cost. The system model of the envisioned IRMC is basically a 3-tier stack with a high-performance DSP in the mid-layer to perform the core tasks of real-time rf data processing and controls. Themore » Digital Front-End (DFE) attachment layer at bottom bridges the applicationspecific rf front-ends to the DSP. A network communication gateway, together with an embedded event receiver (EVR) in the top layer merges the Internet Rack MonitorController node into the networks of the accelerator controls infrastructure. Although the concept is very much in trend with today’s Internet-of-Things (IoT), this implementation has actually been used in the accelerators for over two decades.« less

The FCF Combustion Integrated Rack: Microgravity Combustion Science Onboard the International Space Station

NASA Technical Reports Server (NTRS)

OMalley, Terence F.; Weiland, Karen J.

2002-01-01

The Combustion Integrated Rack (CIR) is one of three facility payload racks being developed for the International Space Station (ISS) Fluids and Combustion Facility (FCF). Most microgravity combustion experiments will be performed onboard the Space Station in the Combustion Integrated Rack. Experiment-specific equipment will be installed on orbit in the CIR to customize it to perform many different scientific experiments during the ten or more years that it will operate on orbit. This paper provides an overview of the CIR, including a description of its preliminary design and planned accommodations for microgravity combustion science experiments, and descriptions of the combustion science experiments currently planned for the CIR.

Laboratory racks are installed in the MPLM Leonardo

NASA Technical Reports Server (NTRS)

2000-01-01

In the Space Station Processing Facility, the Rack Insertion Unit lifts another laboratory rack to the Multi-Purpose Logistics Module Leonardo, in the background. The MPLM is the first of three such pressurized modules that will serve as the International Space Station's '''moving vans,''' carrying laboratory racks filled with equipment, experiments and supplies to and from the International Space Station aboard the Space Shuttle. Leonardo will be launched for the first time March 1, 2001, on Shuttle mission STS-102. On that flight, Leonardo will be filled with equipment and supplies to outfit the U.S. laboratory module, being carried to the ISS on the Jan. 19, 2001, launch of STS-98.

22 CFR 121.5 - Apparatus and devices under Category IV(c).

Code of Federal Regulations, 2010 CFR

2010-04-01

..., modified or configured for items listed in that category, bomb racks and shackles, bomb shackle release units, bomb ejectors, torpedo tubes, torpedo and guided missile boosters, guidance systems equipment and...

Crew Interviews: Treschev

NASA Technical Reports Server (NTRS)

2002-01-01

Sergei Treschev is a Cosmonaut of the Rocket Space Corporation Energia, (RSC), from Volynsky District, Lipetsk Region (Russia). He graduated from Moscow Energy Institute. After years of intense training with RSC Energia, he was selected as International Space Station (ISS) Increment 5 flight engineer. The Expedition-Five crew (two Russian cosmonauts and one American astronaut) will stay on the station for approximately 5 months. The Multipurpose Logistics Module, or MPLM, will carry experiment racks and three stowage and resupply racks to the station. The mission will also install a component of the Canadian Arm called the Mobile Base System (MBS) to the Mobile Transporter (MT) installed during STS-110. This completes the Canadian Mobile Servicing System, or MSS. The mechanical arm will now have the capability to "inchworm" from the U.S. Lab fixture to the MSS and travel along the Truss to work sites.

The ROMPS robot in HitchHiker

NASA Technical Reports Server (NTRS)

Voellmer, George

1992-01-01

The Robotics Branch of the Goddard Space Flight Center has under development a robot that fits inside a Get Away Special can. In the RObotic Materials Processing System (ROMPS) HitchHiker experiment, this robot is used to transport pallets containing wafers of different materials from their storage rack to a halogen lamp furnace for rapid thermal processing in a microgravity environment. It then returns them to their storage rack. A large part of the mechanical design of the robot dealt with the potential misalignment between the various components that are repeatedly mated and demated. A system of tapered guides and compliant springs was designed to work within the robot's force and accuracy capabilities. This paper discusses the above and other robot design issues in detail, and presents examples of ROMPS robot analyses that are applicable to other HitcherHiker materials handling missions.

KSC-02pd0503

NASA Image and Video Library

2002-03-09

KENNEDY SPACE CENTER, FLA. -- In the Orbiter Processing Facility, STS-111 Mission Specialists Phillippe Perrin (left) and Franklin Chang-Diaz (right) check equipment for their mission. Perrin is with the French Space Agency (CNES). Perrin and Chang-Diaz, with other crew members, are taking part in a Crew Equipment Interface Test in preparation for launch. Mission STS-111 will carry to the International Space Station the Multipurpose Logistics Module (MPLM), filled with experiment racks and three stowage and resupply racks, and the Mobile Base System (MBS), which will attach to the Mobile Transporter and complete the Canadian Mobile Servicing System, or MSS. The Station's mechanical arm will then have the capability to "inchworm" from the U.S. Lab to the MSS and travel along the truss to work sites on the Station. Launch of Endeavour on mission STS-111 is scheduled for May 30, 2002

78 FR 33406 - Clean River Power MR-1, LLC, Clean River Power MR-2, LLC, Clean River Power MR-3, LLC, Clean...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-04

..., 52-foot-high, 80-foot-wide intake structure with trash racks containing 2-inch clear bar spacing; (2... following new facilities: (1) A 37-foot-long, 23-foot-high, 80-foot- wide intake structure with trash racks... new facilities: (1) A 37- foot-long, 52-foot-high, 88-foot-wide intake structure with trash racks...

Validation of Modified Wine-Rack Thermal Design for Nickel-Hydrogen Batteries in Landsat-7 Spacecraft Thermal Vacuum Test and in Flight

NASA Technical Reports Server (NTRS)

Choi, Michael K.

1999-01-01

A heritage wine-rack thermal/mechanical design for the nickel-hydrogen batteries was the baseline at the Landsat-7 Preliminary Design Review. An integrated thermal and power analysis of the batteries performed by the author in 1994 revealed that the maximum cell-to-cell gradient was 6.6 C. The author proposed modifying the heritage wine-rack design by enhancing heat conduction from cells to cells, and from cells to battery frame. At the 1995 Intersociety Energy Conversion Engineering Conference (IECEC), the author presented a paper on methods of modifying the wine-rack design. It showed that the modified wine-rack option, which uses a metallic filler, could reduce the maximum cell-to-cell temperature gradient to 1.30 C, and could also reduce the maximum cell temperature by as much as 80 C. That design concept was adopted by the Landsat7 Project Office, and a design change was made at the Critical Design Review. Results of the spacecraft thermal vacuum and thermal balance tests, and temperature data in flight show that the temperatures of the battery cells are very uniform. The maximum cell-to-cell gradient is 1.50 C. They validate the modified wine-rack thermal design.

AMO EXPRESS: A Command and Control Experiment for Crew Autonomy

NASA Technical Reports Server (NTRS)

Stetson, Howard K.; Frank, Jeremy; Cornelius, Randy; Haddock, Angie; Wang, Lui; Garner, Larry

2015-01-01

NASA is investigating a range of future human spaceflight missions, including both Mars-distance and Near Earth Object (NEO) targets. Of significant importance for these missions is the balance between crew autonomy and vehicle automation. As distance from Earth results in increasing communication delays, future crews need both the capability and authority to independently make decisions. However, small crews cannot take on all functions performed by ground today, and so vehicles must be more automated to reduce the crew workload for such missions. NASA's Advanced Exploration Systems Program funded Autonomous Mission Operations (AMO) project conducted an autonomous command and control demonstration of intelligent procedures to automatically initialize a rack onboard the International Space Station (ISS) with power and thermal interfaces, and involving core and payload command and telemetry processing, without support from ground controllers. This autonomous operations capability is enabling in scenarios such as a crew medical emergency, and representative of other spacecraft autonomy challenges. The experiment was conducted using the Expedite the Processing of Experiments for Space Station (EXPRESS) rack 7, which was located in the Port 2 location within the U.S Laboratory onboard the International Space Station (ISS). Activation and deactivation of this facility is time consuming and operationally intensive, requiring coordination of three flight control positions, 47 nominal steps, 57 commands, 276 telemetry checks, and coordination of multiple ISS systems (both core and payload). The autonomous operations concept includes a reduction of the amount of data a crew operator is required to verify during activation or de-activation, as well as integration of procedure execution status and relevant data in a single integrated display. During execution, the auto-procedures provide a step-by-step messaging paradigm and a high level status upon termination. This messaging and high level status is the only data generated for operator display. To enhance situational awareness of the operator, the Web-based Procedure Display (WebPD) provides a novel approach to the issues of procedure display and execution tracking. For this demonstration, the procedure was initiated and monitored from the ground. As the Timeliner sequences executed, their high level execution status was transmitted to ground, for WebPD consumption.

Steering and Suspension Systems. Auto Mechanics Curriculum Guide. Module 5. Instructor's Guide.

ERIC Educational Resources Information Center

Rains, Larry

This module is the fifth of nine modules in the competency-based Missouri Auto Mechanics Curriculum Guide. Seventeen units cover: steering system design; diagnosing steering systems problems; inspecting and replacing steering linkage components; manual and power steering gear service; manual and power rack and pinion steering gear service; power…

Early activation of nSMase2/ceramide pathway in astrocytes is involved in ischemia-associated neuronal damage via inflammation in rat hippocampi

PubMed Central

2013-01-01

Background Ceramide accumulation is considered a contributing factor to neuronal dysfunction and damage. However, the underlying mechanisms that occur following ischemic insult are still unclear. Methods In the present study, we established cerebral ischemia models using four-vessel occlusion and oxygen-glucose deprivation methods. The hippocampus neural cells were subjected to immunohistochemistry and immunofluorescence staining for ceramide and neutral sphingomyelinase 2 (nSMase2) levels; immunoprecipitation and immunoblot analysis for nSMase2, receptor for activated C kinase 1 (RACK1), embryonic ectoderm development (EED), p38 mitogen-activated protein kinase (p38MAPK) and phosphorylated p38MAPK expression; SMase assay for nSMase and acid sphingomyelinase (aSMase) activity; real-time reverse transcription polymerase chain reaction for cytokine expression; and Nissl, microtubule-associated protein 2 and terminal deoxynucleotidyl transferase–mediated deoxyuridine triphosphate nick-end labeling staining. Results We found considerable production of ceramide in astrocytes, but not in neurons, during early cerebral ischemia. This was accompanied by the induction of nSMase (but not aSMase) activity in the rat hippocampi. The inhibition of nSMase2 activity effectively reduced ceramide accumulation in astrocytes and alleviated neuronal damage to some extent. Meanwhile, the expression levels of proinflammatory cytokines, including tumor necrosis factor α (TNF-α), interleukin 1β (IL-1β) and IL-6, were found to be upregulated, which may have played an import role in neuronal damage mediated by the nSMase2/ceramide pathway. Although enhanced binding of nSMase2 with RACK1 and EED were also observed after cerebral ischemia, nSMase2 activity was not blocked by the TNF-α receptor inhibitor through RACK1/EED signaling. p38MAPK, but not protein kinase Cζ or protein phosphatase 2B, was able to induce nSMase2 activation after ischemia. p38MAPK can be induced by A2B adenosine receptor (A2BAR) activity. Conclusions These results indicate that the inhibition of ceramide production in astrocytes by targeting A2BAR/p38MAPK/nSMase2 signaling may represent a viable approach for attenuating inflammatory responses and neuronal damage after cerebral ischemia. PMID:24007266

20. OVERVIEW OF SAR3 COMPLEX, SHOWING FORMER RESIDENTIAL AREA, SAR3 ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

20. OVERVIEW OF SAR-3 COMPLEX, SHOWING FORMER RESIDENTIAL AREA, SAR-3 SWITCH RACK, MAINTENANCE YARD, AND GREENSPOT BRIDGE. NOTE ALSO LARGE PIPE CONDUCTING TAILRACE WATER INTO IRRIGATION SYSTEM. VIEW TO SOUTHWEST. - Santa Ana River Hydroelectric System, Redlands, San Bernardino County, CA

43. Upper level, left to rightground missile guidance system liquid ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

43. Upper level, left to right--ground missile guidance system liquid cooling equipment, guidance and control coupler rack, programmer group - Ellsworth Air Force Base, Delta Flight, Launch Facility, On County Road T512, south of Exit 116 off I-90, Interior, Jackson County, SD

Scavenge/remove an AAA (Avionics Air Assembly) filter

NASA Image and Video Library

2009-08-25

ISS020-E-033979 (25 Aug. 2009) --- NASA astronaut Michael Barratt, Expedition 20 flight engineer, works with the Crew Health Care System (CHeCS) rack in the Kibo laboratory of the International Space Station.

Microgravity

NASA Image and Video Library

1999-01-01

Line drawing depicts the location of one of three racks that will make up the Materials Science Research Facility in the U.S. Destiny laboratory module to be attached to the International Space Station (ISS). Other positions will be occupied by a variety of racks supporting research in combustion, fluids, biotechnology, and human physiology, and racks to support lab and station opertions. The Materials Science Research Facility is managed by NASA's Marshall Space Flight Center. Photo credit: NASA/Marshall Space Flight Center

Microgravity

NASA Image and Video Library

2000-01-30

Engineers from NASA's Glenn Research Center, demonstrate access to one of the experiment racks planned for the U.S. Destiny laboratory module on the International Space Station. This mockup has the full diameter, full corridor width, and half the length of the module. The mockup includes engineering mockups of the Fluids and Combustion Facility being developed by NASA's Glenn Research Center. (The full module will be six racks long; the mockup is three rack long) Photo credit: NASA/Marshall Space Flight Center

40 CFR 63.2396 - What compliance options do I have if part of my plant is subject to both this subpart and another...

Code of Federal Regulations, 2010 CFR

2010-07-01

... criteria for control in table 2 to this subpart. (b) Compliance with other regulations for transfer racks. After the compliance dates specified in § 63.2342, if you have a transfer rack that is subject to 40 CFR part 61, subpart BB, and that transfer rack is in OLD operation, you must meet all of the requirements...

115. VIEW OF SOUTHWEST CORNER OF LANDLINE INSTRUMENTATION ROOM (206), ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

115. VIEW OF SOUTHWEST CORNER OF LANDLINE INSTRUMENTATION ROOM (206), LSB (BLDG. 751). BATTERY RACK ON LEFT FOR BACKUP BOOSTER POWER; BATTERY RACK ON RIGHT FOR BACKUP AEROSPACE GROUND EQUIPMENT (AGE) POWER. RECTIFIER SUPPLYING PRIMARY POWER ON THE RIGHT SIDE OF THE PHOTO; BATTERY CHARGER BETWEEN RECTIFIER AND BATTERY RACKS. - Vandenberg Air Force Base, Space Launch Complex 3, Launch Pad 3 East, Napa & Alden Roads, Lompoc, Santa Barbara County, CA

Laboratory and Field Application of River Depth Estimation Techniques Using Remotely Sensed Data: Annual Report Year 1

DTIC Science & Technology

2013-09-30

coordinates locally oriented in the streamwise and cross-stream directions, respectively. To test the expressions and investigate potential errors, we...Survey Geomorphology and Sediment Transport Laboratory (GSTL). The IR camera was mounted on a rack ~1m above the surface of the flow and oriented so that...MD_SWMS, American Society for Photogrammetry and Remote Sensing, Proceedings of the 2008 Annual Conference –PNAMP Special Session: Remote Sensing

40 CFR 63.126 - Transfer operations provisions-reference control technology.

Code of Federal Regulations, 2014 CFR

2014-07-01

... Wastewater § 63.126 Transfer operations provisions—reference control technology. (a) For each Group 1... control device. (1) Each vapor collection system shall be designed and operated to collect the organic... process, fuel gas system, or control device shall be operating. (b) For each Group 1 transfer rack the...

The CGE-PLATO Electronic Laboratory Station Structure and Operation.

ERIC Educational Resources Information Center

Neal, J. P.

An electronic laboratory station was designed for student use in learning electronic instrumentation and measurement by means of the computer-guided experimentation (CGE) system. The station features rack-mounted electronic laboratory equipment on a laboratory table adjacent to a PLATO IV terminal. An integrated logic system behind the laboratory…

27 CFR 24.266 - Inventory losses.

Code of Federal Regulations, 2014 CFR

2014-04-01

... losses due to spillage, leakage, soakage, evaporation, and other losses normally occurring from racking... spillage, leakage, soakage, evaporation, and other losses normally occurring from racking and filtering. In...

27 CFR 24.266 - Inventory losses.

Code of Federal Regulations, 2011 CFR

2011-04-01

... losses due to spillage, leakage, soakage, evaporation, and other losses normally occurring from racking... spillage, leakage, soakage, evaporation, and other losses normally occurring from racking and filtering. In...

27 CFR 24.266 - Inventory losses.

Code of Federal Regulations, 2013 CFR

2013-04-01

... losses due to spillage, leakage, soakage, evaporation, and other losses normally occurring from racking... spillage, leakage, soakage, evaporation, and other losses normally occurring from racking and filtering. In...

27 CFR 24.266 - Inventory losses.

Code of Federal Regulations, 2012 CFR

2012-04-01

... losses due to spillage, leakage, soakage, evaporation, and other losses normally occurring from racking... spillage, leakage, soakage, evaporation, and other losses normally occurring from racking and filtering. In...

Definition of a RACK1 Interaction Network in Drosophila melanogaster Using SWATH-MS.

PubMed

Kuhn, Lauriane; Majzoub, Karim; Einhorn, Evelyne; Chicher, Johana; Pompon, Julien; Imler, Jean-Luc; Hammann, Philippe; Meignin, Carine

2017-07-05

Receptor for Activated protein C kinase 1 (RACK1) is a scaffold protein that has been found in association with several signaling complexes, and with the 40S subunit of the ribosome. Using the model organism Drosophila melanogaster , we recently showed that RACK1 is required at the ribosome for internal ribosome entry site (IRES)-mediated translation of viruses. Here, we report a proteomic characterization of the interactome of RACK1 in Drosophila S2 cells. We carried out Label-Free quantitation using both Data-Dependent and Data-Independent Acquisition (DDA and DIA, respectively) and observed a significant advantage for the Sequential Window Acquisition of all THeoretical fragment-ion spectra (SWATH) method, both in terms of identification of interactants and quantification of low abundance proteins. These data represent the first SWATH spectral library available for Drosophila and will be a useful resource for the community. A total of 52 interacting proteins were identified, including several molecules involved in translation such as structural components of the ribosome, factors regulating translation initiation or elongation, and RNA binding proteins. Among these 52 proteins, 15 were identified as partners by the SWATH strategy only. Interestingly, these 15 proteins are significantly enriched for the functions translation and nucleic acid binding. This enrichment reflects the engagement of RACK1 at the ribosome and highlights the added value of SWATH analysis. A functional screen did not reveal any protein sharing the interesting properties of RACK1, which is required for IRES-dependent translation and not essential for cell viability. Intriguingly however, 10 of the RACK1 partners identified restrict replication of Cricket paralysis virus (CrPV), an IRES-containing virus. Copyright © 2017 Kuhn et al.

Microgravity

NASA Image and Video Library

2000-01-30

Engineers from NASA's Glen Research Center demonstrate the access to one of the experiment racks plarned for the U.S. Destiny laboratory module on the International Space Station (ISS). This mockup has the full diameter, full corridor width, and half the length of the module. The mockup includes engineering mockups of the Fluids and Combustion Facility being developed by NASA's Glenn Research Center. (The full module will be six racks long; the mockup is three racks long). Photo credit: NASA/Marshall Space Flight Center (MSFC)

Space Station Furnace Facility. Experiment/Facility Requirements Document (E/FRD), volume 2, appendix 5

NASA Technical Reports Server (NTRS)

Kephart, Nancy

1992-01-01

The function of the Space Station Furnace Facility (SSFF) is to support materials research into the crystal growth and solidification processes of electronic and photonic materials, metals and alloys, and glasses and ceramics. To support this broad base of research requirements, the SSFF will employ a variety of furnace modules operated, regulated, and supported by a core of common subsystems. Furnace modules may be reconfigured or specifically developed to provide unique solidifcation conditions for each set of experiments. The SSFF modular approach permits the addition of new or scaled-up furnace modules to support the evolution of the facility as new science requirements are identified. The SSFF Core is of modular design to permit augmentation for enhanced capabilities. The fully integrated configuration of the SSFF will consist of three racks with the capability of supporting up to two furnace modules per rack. The initial configuration of the SSFF will consist of two of the three racks and one furnace module. This Experiment/Facility Requirements Document (E/FRD) describes the integrated facility requirements for the Space Station Freedom (SSF) Integrated Configuration-1 (IC1) mission. The IC1 SSFF will consist of two racks: the Core Rack, with the centralized subsystem equipment, and the Experiment Rack-1, with Furnace Module-1 and the distributed subsystem equipment to support the furnace.

EMC Test Report Electrodynamic Dust Shield

NASA Technical Reports Server (NTRS)

Carmody, Lynne M.; Boyette, Carl B.

2014-01-01

This report documents the Electromagnetic Interference E M I evaluation performed on the Electrodynamic Dust Shield (EDS) which is part of the MISSE-X System under the Electrostatics and Surface Physics Laboratory at Kennedy Space Center. Measurements are performed to document the emissions environment associated with the EDS units. The purpose of this report is to collect all information needed to reproduce the testing performed on the Electrodynamic Dust Shield units, document data gathered during testing, and present the results. This document presents information unique to the measurements performed on the Bioculture Express Rack payload; using test methods prepared to meet SSP 30238 requirements. It includes the information necessary to satisfy the needs of the customer per work order number 1037104. The information presented herein should only be used to meet the requirements for which it was prepared.

KSC-02pd0506

NASA Image and Video Library

2002-03-09

KENNEDY SPACE CENTER, FLA. -- Members of the STS-111 crew (dressed in green) look over equipment in the payload bay of Endeavour. The crew comprises Commander Kenneth Cockrell, Pilot Paul Lockhart and Mission Specialists Franklin Chang-Diaz and Phillipe Perrin, who is with the French Space Agency (CNES). The crew is taking part in a Crew Equipment Interface Test in preparation for launch. Mission STS-111 will carry to the International Space Station the Multipurpose Logistics Module (MPLM), filled with experiment racks and three stowage and resupply racks, and the Mobile Base System (MBS), which will attach to the Mobile Transporter and complete the Canadian Mobile Servicing System, or MSS. The Station's mechanical arm will then have the capability to "inchworm" from the U.S. Lab to the MSS and travel along the truss to work sites on the Station. Launch of Endeavour on mission STS-111 is scheduled for May 30, 2002

KSC-02pd0505

NASA Image and Video Library

2002-03-09

KENNEDY SPACE CENTER, FLA. -- In the Orbiter Processing Facility, STS-111 Mission Specialists Franklin Chang-Diaz (center) and Phillippe Perrin (right) check equipment with a trainer (left) in orbiter Endeavour. Perrin is with the French Space Agency (CNES). Perrin and Chang-Diaz, with other crew members, are taking part in a Crew Equipment Interface Test in preparation for launch. Mission STS-111 will carry to the International Space Station the Multipurpose Logistics Module (MPLM), filled with experiment racks and three stowage and resupply racks, and the Mobile Base System (MBS), which will attach to the Mobile Transporter and complete the Canadian Mobile Servicing System, or MSS. The Station's mechanical arm will then have the capability to "inchworm" from the U.S. Lab to the MSS and travel along the truss to work sites on the Station. Launch of Endeavour on mission STS-111 is scheduled for May 30, 2002

Going Digital - The Transition from Mark IV to DBBC at Onsala

NASA Astrophysics Data System (ADS)

Kareinen, Niko; Haas, Rüdiger; La Porta, Laura; Bertarini, Alessandra

2014-12-01

The Onsala Space Observatory is currently equipped with both a VLBI Mark IV rack and a digital BBC (DBBC). The Mark IV rack at Onsala has been used operationally for both astronomical and geodetic VLBI for more than 40 years. In 2011, Onsala purchased a DBBC and we started to test it and to gain experience with the new device, both for astronomical and geodetic VLBI. The DBBC was upgraded several times and the Field System (FS) interface was implemented. We did parallel recordings, with both the old Mark IV/Mark 5A system and the new DBBC/Mark 5B+ system, during numerous geodetic VLBI sessions. Several R1, T2, and Euro sessions were correlated during the last two years by the Bonn correlator with Onsala being included both as an analog station (two-letter code On) and as a digital station (two-letter code Od). We present results from these parallel sessions, both results from the original correlation and results from the analysis of the corresponding databases.

77 FR 2974 - Longview Energy Exchange, LLC; Notice of Preliminary Permit Application Accepted for Filing and...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-01-20

... system; (2) a single lower reservoir dam constructed of earth fill materials with an internal dam drainage system; (3) concrete inlet-outlet structures at both upper reservoirs equipped with trash racks..., using the eComment system at http://www.ferc.gov/docs-filing/ecomment.asp . You must include your name...

Design and Strength check of Large Blow Molding Machine Rack

NASA Astrophysics Data System (ADS)

Fei-fei, GU; Zhi-song, ZHU; Xiao-zhao, YAN; Yi-min, ZHU

Design procedure of large blow moulding machine rack is discussed in the article. A strength checking method is presented. Finite element analysis is conducted in the design procedure by ANSYS software. The actual situation of the rack load bearing is fully considered. The necessary means to simplify the model are done. The dimensional linear element Beam 188 is analyzed. MESH200 is used to mesh. Therefore, it simplifies the analysis process and improves computational efficiency. The maximum deformation of rack is 8.037 mm: it is occurred in the position of accumulator head. The result states: it meets the national standard curvature which is not greater than 0.3% of the total channel length; it also meets strength requirement that the maximum stress was 54.112 MPa.

CM-2 Environmental / Modal Testing of Spacehab Racks

NASA Technical Reports Server (NTRS)

McNelis, Mark E.; Goodnight, Thomas W.; Farkas, Michael A.

2001-01-01

Combined environmental/modal vibration testing has been implemented at the NASA Glenn Research Center's Structural Dynamics Laboratory. The benefits of combined vibration testing are that it facilitates test article modal characterization and vibration qualification testing. The Combustion Module-2 (CM-2) is a space experiment that launches on Shuttle mission STS 107 in the SPACEHAB Research Double Module. The CM-2 flight hardware is integrated into a SPACEHAB single and double rack. CM-2 rack level combined vibration testing was recently completed on a shaker table to characterize the structure's modal response and verify the random vibration response. Control accelerometers and limit force gauges, located between the fixture and rack interface, were used to verify the input excitation. Results of the testing were used to verify the loads and environments for flight on the Shuttle.

INTERIOR OF COLD STORAGE ROOM, SHOWING MOVABLE HANGING RACKS. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

INTERIOR OF COLD STORAGE ROOM, SHOWING MOVABLE HANGING RACKS. - Naval Air Station Barbers Point, Aircraft Storehouse, Between Midway & Card Streets at Enterprise Avenue intersection, Ewa, Honolulu County, HI

Wakata performs microscopic analysis of the NanoRacks Module-38 Petri Dishes

NASA Image and Video Library

2014-01-13

ISS038-E-029082 (12 Jan. 2014) --- Japan Aerospace Exploration Agency astronaut Koichi Wakata, Expedition 38 flight engineer, performs microscopic analysis of the NanoRacks Module-38 Petri Dishes, using Celestron Reflective Microscope, in the Kibo laboratory of the International Space Station. These Module-38 experiments are designed by students as part of a competition sponsored by the International Space School Educational Trust (ISSET). This experiment examines three-dimensional growth of slime mold in petri dishes utilizing the NanoRacks Microscopes Facility.

Deformation and Flexibility Equations for Idealized ARIS Umbilicals, Under Planar End-Loading Conditions

NASA Technical Reports Server (NTRS)

Hampton, R. David; Quraishi, Naveed (Technical Monitor)

2003-01-01

The International Space Station (ISS) relies on the Active Rack Isolation System (ARIS) as the central component of an integrated, station-wide strategy to isolate microgravity space-science experiments. ARIS uses electromechanical actuators to isolate an International Standard Payload Rack (ISPR) from disturbances due to the motion of the ISS. Disturbances to microgravity experiments on ARIS-isolated racks are primarily transmitted via the ARTS power and vacuum umbilicals. Recent experimental tests indicate that these umbilicals resonate at frequencies outside the ARIS controller's bandwidth, at levels of potential concern for certain microgravity experiments. Reduction in the umbilical resonant frequencies could help to address this issue. This report develops equations for the in-plane deflections and flexibilities of an idealized umbilical (thin, flexible, cantilever beam) under end-point, in-plane loading (inclined-force and moment). The effect of gravity is neglected due to the on-orbit application. The analysis assumes an initially straight, cantilevered umbilical with uniform cross-section, which undergoes large deflections with no plastic deformation, such that the umbilical terminus remains in a single quadrant and the umbilical slope changes monotonically. The analysis is applicable to the ARIS power and vacuum umbilicals, under the indicated assumptions.

Deformation and Flexibility Equations for Idealized ARIS Umbilicals, Under Planar End-Loading Conditions

NASA Technical Reports Server (NTRS)

Hampton, R. David; Quraishi, Naveed; Rupert, Jason K.

2000-01-01

The International Space Station (ISS) relies on the Active Rack Isolation System (ARIS) as the central component of an integrated, station-wide strategy to isolate microgravity space-science experiments. ARIS uses electromechanical actuators to isolate an International Standard Payload Rack (ISPR) from disturbances due to the motion of the ISS. Disturbances to microgravity experiments on ARIS-isolated racks are primarily transmitted via the ARIS power and vacuum umbilicals. Recent experimental tests indicate that these umbilicals resonate at frequencies outside the ARIS controller's bandwidth. at levels of potential concern for certain microgravity experiments. Reduction in the umbilical resonant frequencies could help to address this issue. This paper develops equations for the in-plane deflections and flexibilities of an idealized umbilical (thin, flexible, cantilever beam) under end-point, in-plane loading (inclined-force and moment). The effect of gravity is neglected due to the on:orbit application. The analysis assumes an initially straight. cantilevered umbilical with uniform cross-section. which undergoes large deflections with no plastic deformation, such that the umbilical terminus remains in a single quadrant and the umbilical slope changes monotonically. The analysis is applicable to the ARIS power and vacuum umbilicals. under the indicated assumptions.

Deformation and Flexibility Equations for ARIS Umbilicals Idealized as Planar Elastica

NASA Technical Reports Server (NTRS)

Hampton, R. David; Leamy, Michael J.; Bryant, Paul J.; Quraishi, Naveed

2005-01-01

The International Space Station relies on the active rack isolation system (ARIS) as the central component of an integrated, stationwide strategy to isolate microgravity space-science experiments. ARIS uses electromechanical actuators to isolate an international standard payload rack from disturbances due to the motion of the Space Station. Disturbances to microgravity experiments on ARIS isolated racks are transmitted primarily via the ARIS power and vacuum umbilicals. Experimental tests indicate that these umbilicals resonate at frequencies outside the ARIS controller s bandwidth at levels of potential concern for certain microgravity experiments. Reduction in the umbilical resonant frequencies could help to address this issue. This work documents the development and verification of equations for the in-plane deflections and flexibilities of an idealized umbilical (thin, flexible, inextensible, cantilever beam) under end-point, in-plane loading (inclined-force and moment). The effect of gravity is neglected due to the on-orbit application. The analysis assumes an initially curved (not necessarily circular), cantilevered umbilical with uniform cross-section, which undergoes large deflections with no plastic deformation, such that the umbilical slope changes monotonically. The treatment is applicable to the ARIS power and vacuum umbilicals under the indicated assumptions.

Combustion Integrated Rack (CIR)

NASA Image and Video Library

2016-06-22

NASA Glenn engineer Chris Mroczka installs a gas-jet burner in a chamber within the center’s Combustion Integrated Rack. This chamber is where scientists conduct gaseous combustion experiments in a zero gravity environment.

40 CFR 65.87 - Recordkeeping provisions.

Code of Federal Regulations, 2010 CFR

2010-07-01

... (CONTINUED) CONSOLIDATED FEDERAL AIR RULE Transfer Racks § 65.87 Recordkeeping provisions. The owner or operator of a transfer rack shall record that either the verification of U.S. Department of Transportation...

STS-100 MPLM Raffaello is moved to the payload canister

NASA Technical Reports Server (NTRS)

2001-01-01

KENNEDY SPACE CENTER, Fla. - The Multi-Purpose Logistics Module Raffaello is lowered into the payload canister alongside the Canadian robotic arm, SSRMS, already in place. Both elements are part of the payload on mission STS-100 to the International Space Station. Raffaello carries six system racks and two storage racks for the U.S. Lab. The arm has seven motorized joints and is capable of handling large payloads and assisting with docking the Space Shuttle. The SSRMS is self-relocatable with a Latching End Effector so it can be attached to complementary ports spread throughout the Station'''s exterior surfaces. Launch of STS-100 is scheduled for April 19, 2001 at 2:41 p.m. EDT from Launch Pad 39A.

STS-100 MPLM Raffaello is moved to the payload canister

NASA Technical Reports Server (NTRS)

2001-01-01

KENNEDY SPACE CENTER, Fla. - Viewed from the end, the Multi- Purpose Logistics Module Raffaello is lowered into the payload canister behind the Canadian robotic arm, SSRMS, already in place. Both elements are part of the payload on mission STS-100 to the International Space Station. Raffaello carries six system racks and two storage racks for the U.S. Lab. The arm has seven motorized joints and is capable of handling large payloads and assisting with docking the Space Shuttle. The SSRMS is self- relocatable with a Latching End Effector so it can be attached to complementary ports spread throughout the Station'''s exterior surfaces. Launch of STS-100 is scheduled for April 19, 2001 at 2:41 p.m. EDT from Launch Pad 39A.

U.S. Rep. Dave Weldon outside the U.S. Lab Destiny in the SSPF.

NASA Technical Reports Server (NTRS)

1999-01-01

Standing in front of the U.S. Lab, named Destiny, U.S. Rep. Dave Weldon (left) thanks Thomas R. 'Randy' Galloway, with the Space Station Hardware Integration Office, for briefing him on the equipment inside the Lab. Weldon is on the House Science Committee and vice chairman of the Space and Aeronautics Subcommittee. Destiny is scheduled to be launched on Space Shuttle Endeavour in early 2000. It will become the centerpiece of scientific research on the ISS, with five equipment racks aboard to provide essential functions for station systems, including high data-rate communications, and to maintain the station's orientation using control gyroscopes launched earlier. Additional equipment and research racks will be installed in the laboratory on subsequent Shuttle flights.

KSC-01pp1425

NASA Image and Video Library

2001-08-06

KENNEDY SPACE CENTER, Fla. -- On Launch Pad 39A, Discovery’s payload bay doors close on the payloads inside. On the Integrated Cargo Carrier seen here is the Early Ammonia Servicer (EAS) on the left. The EAS contains spare ammonia for the Station’s cooling system. Ammonia is the fluid used in the radiators that cool the Station’s electronics. The EAS will be installed on the P6 truss holding the giant U.S. solar arrays, batteries and cooling radiators. Other payloads in the bay are the Multi-Purpose Logistics Module Leonardo, filled with laboratory racks of science equipment and racks and platforms of experiments and supplies, and various experiments attached on the port and starboard adapter beams. Discovery is scheduled to be launched Aug. 9, 2001

STS-55 German Payload Specialist Schlegel manipulates ROTEX controls in SL-D2

NASA Image and Video Library

1993-05-06

STS055-106-100 (26 April-6 May 1993) --- Hans Schlegel, wearing special glasses, works at the Robotics Experiment (ROTEX) workstation in the science module aboard the Earth-orbiting Space Shuttle Columbia. Schlegel was one of two payload specialists representing the German Aerospace Research Establishment (DLR) on the 10-day Spacelab D-2 mission. ROTEX is a robotic arm that operates within an enclosed workcell in rack 6 of the Spacelab module and uses teleoperation from both an onboard station located nearby in rack 4 and from a station on the ground. The device uses teleprogramming and artificial intelligence to look at the design, verification and operation of advanced autonomous systems for use in future applications.

Next generation platforms for high-throughput biodosimetry.

PubMed

Repin, Mikhail; Turner, Helen C; Garty, Guy; Brenner, David J

2014-06-01

Here the general concept of the combined use of plates and tubes in racks compatible with the American National Standards Institute/the Society for Laboratory Automation and Screening microplate formats as the next generation platforms for increasing the throughput of biodosimetry assays was described. These platforms can be used at different stages of biodosimetry assays starting from blood collection into microtubes organised in standardised racks and ending with the cytogenetic analysis of samples in standardised multiwell and multichannel plates. Robotically friendly platforms can be used for different biodosimetry assays in minimally equipped laboratories and on cost-effective automated universal biotech systems. © The Author 2014. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

40 CFR 65.144 - Fuel gas systems and processes to which storage vessel, transfer rack, or equipment leak...

Code of Federal Regulations, 2010 CFR

2010-07-01

...; (ii) Transformed by chemical reaction into materials that are not regulated materials; (iii... section for a storage vessel, the owner or operator shall prepare a design evaluation (or engineering...

Clock Technology Development in the Laser Cooling and Atomic Physics (LCAP) Program

NASA Technical Reports Server (NTRS)

Seidel, Dave; Thompson, R. J.; Klipstein, W. M.; Kohel, J.; Maleki, L.

2000-01-01

This paper presents the Laser Cooling and Atomic Physics (LCAP) program. It focuses on clock technology development. The topics include: 1) Overview of LCAP Flight Projects; 2) Space Clock 101; 3) Physics with Clocks in microgravity; 4) Space Clock Challenges; 5) LCAP Timeline; 6) International Space Station (ISS) Science Platforms; 7) ISS Express Rack; 8) Space Qualification of Components; 9) Laser Configuration; 10) Clock Rate Comparisons: GPS Carrier Phase Frequency Transfer; and 11) ISS Model Views. This paper is presented in viewgraph form.

Antenna cab interior showing equipment rack and fiberglass antenna panels, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Antenna cab interior showing equipment rack and fiberglass antenna panels, looking west. - Western Union Telegraph Company, Jennerstown Relay, Laurel Summit Road off U.S. 30, Laughlintown, Westmoreland County, PA

Antenna cab interior showing equipment rack and fiberglass antenna panels, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Antenna cab interior showing equipment rack and fiberglass antenna panels, looking southeast. - Western Union Telegraph Company, Jennerstown Relay, Laurel Summit Road off U.S. 30, Laughlintown, Westmoreland County, PA

10 CFR 36.41 - Construction monitoring and acceptance testing.

Code of Federal Regulations, 2010 CFR

2010-01-01

... system will operate properly if offsite power is lost and shall verify that the computer has security... system to assure that the requirements in § 36.35 are met for protection of the source rack and the... protection. For panoramic irradiators, the licensee shall test the ability of the heat and smoke detectors to...

10 CFR 36.41 - Construction monitoring and acceptance testing.

Code of Federal Regulations, 2011 CFR

2011-01-01

... system will operate properly if offsite power is lost and shall verify that the computer has security... system to assure that the requirements in § 36.35 are met for protection of the source rack and the... protection. For panoramic irradiators, the licensee shall test the ability of the heat and smoke detectors to...

10 CFR 36.41 - Construction monitoring and acceptance testing.

Code of Federal Regulations, 2014 CFR

2014-01-01

... system will operate properly if offsite power is lost and shall verify that the computer has security... system to assure that the requirements in § 36.35 are met for protection of the source rack and the... protection. For panoramic irradiators, the licensee shall test the ability of the heat and smoke detectors to...

10 CFR 36.41 - Construction monitoring and acceptance testing.

Code of Federal Regulations, 2012 CFR

2012-01-01

... system will operate properly if offsite power is lost and shall verify that the computer has security... system to assure that the requirements in § 36.35 are met for protection of the source rack and the... protection. For panoramic irradiators, the licensee shall test the ability of the heat and smoke detectors to...

10 CFR 36.41 - Construction monitoring and acceptance testing.

Code of Federal Regulations, 2013 CFR

2013-01-01

... system will operate properly if offsite power is lost and shall verify that the computer has security... system to assure that the requirements in § 36.35 are met for protection of the source rack and the... protection. For panoramic irradiators, the licensee shall test the ability of the heat and smoke detectors to...

18. Detail view of central pivot pier, drive gear rack, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

18. Detail view of central pivot pier, drive gear rack, and stabilizing wheel, looking southwest - India Point Railroad Bridge, Spanning Seekonk River between Providence & East Providence, Providence, Providence County, RI

4. DETAIL VIEW OF LIFTING GEAR ON MULE AND RACK ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

4. DETAIL VIEW OF LIFTING GEAR ON MULE AND RACK ATTACHMENT BOOKS, LOOKING EAST - Nine Mile Hydroelectric Development, Powerhouse, State Highway 291 along Spokane River, Nine Mile Falls, Spokane County, WA

Materials Science Research Rack-1 (MSRR-1)

NASA Technical Reports Server (NTRS)

2001-01-01

This computer-generated image depicts the Materials Science Research Rack-1 (MSRR-1) being developed by NASA's Marshall Space Flight Center and the European Space Agency (ESA) for placement in the Destiny laboratory module aboard the International Space Station. The rack is part of the plarned Materials Science Research Facility (MSRF) and is expected to include two furnace module inserts, a Quench Module Insert (being developed by NASA's Marshall Space Flight Center) to study directional solidification in rapidly cooled alloys and a Diffusion Module Insert (being developed by the European Space Agency) to study crystal growth, and a transparent furnace (being developed by NASA's Space Product Development program). Multi-user equipment in the rack is being developed under the auspices of NASA's Office of Biological and Physical Research (OBPR) and ESA. Key elements are labeled in other images (0101754, 0101829, 0101830, and TBD).

Materials Science Research Rack-1 (MSRR-1)

NASA Technical Reports Server (NTRS)

2001-01-01

This computer-generated image depicts the Materials Science Research Rack-1 (MSRR-1) being developed by NASA's Marshall Space Flight Center and the European Space Agency (ESA) for placement in the Destiny laboratory module aboard the International Space Station. The rack is part of the plarned Materials Science Research Facility (MSRF) and is expected to include two furnace module inserts, a Quench Module Insert (being developed by NASA's Marshall Space Flight Center) to study directional solidification in rapidly cooled alloys and a Diffusion Module Insert (being developed by the European Space Agency) to study crystal growth, and a transparent furnace (being developed by NASA's Space Product Development program). Multi-user equipment in the rack is being developed under the auspices of NASA's Office of Biological and Physical Research (OBPR) and ESA. A larger image is available without labels (No. 0101755).

Materials Science Research Rack-1 (MSRR-1)

NASA Technical Reports Server (NTRS)

2001-01-01

This computer-generated image depicts the Materials Science Research Rack-1 (MSRR-1) being developed by NASA's Marshall Space Flight Center and the European Space Agency (ESA) for placement in the Destiny laboratory module aboard the International Space Station. The rack is part of the plarned Materials Science Research Facility (MSRF) and is expected to include two furnace module inserts, a Quench Module Insert (being developed by NASA's Marshall Space Flight Center) to study directional solidification in rapidly cooled alloys and a Diffusion Module Insert (being developed by the European Space Agency) to study crystal growth, and a transparent furnace (being developed by NASA's Space Product Development program). Multi-user equipment in the rack is being developed under the auspices of NASA's Office of Biological and Physical Research (OBPR) and ESA. Key elements are labeled in other images (0101754, 0101830, and TBD).

Materials Science Research Rack-1 (MSRR-1)

NASA Technical Reports Server (NTRS)

2001-01-01

This scale model depicts the Materials Science Research Rack-1 (MSRR-1) being developed by NASA's Marshall Space Flight Center and the European Space Agency (ESA) for placement in the Destiny laboratory module aboard the International Space Station. The rack is part of the plarned Materials Science Research Facility (MSRF) and is expected to include two furnace module inserts, a Quench Module Insert (being developed by NASA's Marshall Space Flight Center) to study directional solidification in rapidly cooled alloys and a Diffusion Module Insert (being developed by the European Space Agency) to study crystal growth, and a transparent furnace (being developed by NASA's Space Product Development program). Multi-user equipment in the rack is being developed under the auspices of NASA's Office of Biological and Physical Research (OBPR) and ESA. Key elements are labeled in other images (0101754, 0101829, 0101830, and TBD).

Materials Science Research Rack-1 (MSRR-1)

NASA Technical Reports Server (NTRS)

2001-01-01

This computer-generated image depicts the Materials Science Research Rack-1 (MSRR-1) being developed by NASA's Marshall Space Flight Center and the European Space Agency (ESA) for placement in the Destiny laboratory module aboard the International Space Station. The rack is part of the plarned Materials Science Research Facility (MSRF) and is expected to include two furnace module inserts, a Quench Module Insert (being developed by NASA's Marshall Space Flight Center) to study directional solidification in rapidly cooled alloys and a Diffusion Module Insert (being developed by the European Space Agency) to study crystal growth, and a transparent furnace (being developed by NASA's Space Product Development program). Multi-user equipment in the rack is being developed under the auspices of NASA's Office of Biological and Physical Research (OBPR) and ESA. Key elements are labeled in other images (0101754, 0101829, 0101830).

KSC-05PD-0372

NASA Technical Reports Server (NTRS)

2005-01-01

KENNEDY SPACE CENTER, FLA. In the Space Station Processing Facility, the Rack Insertion Device moves the Human Research Facility-2 (HRF-2) science rack toward the Multi-Purpose Logistics Module Raffaello (at left) for flight on Space Shuttle Discoverys Return to Flight mission, STS-114. The HRF-2 will deliver additional biomedical instrumentation and research capability to the International Space Station. HRF-1, installed on the U.S. Lab since May 2001, contains an ultrasound unit and gas analyzer. Both racks provide structural, power, thermal, command and data handling, and communication and tracking interfaces between the HRF biomedical instrumentation and the U.S. Laboratory, Destiny. NASA Kennedy Space Center and their prime contractor responsible for ISS element processing, The Boeing Company, prepared the rack for installation. The HRF Project is managed by NASA Johnson Space Center and implemented through contract with Lockheed Martin, Houston, Texas.

'Swab racks are an old fashioned idea'.

PubMed

Mumford, M

1991-12-01

Mary Mumford, theatre sister at the Princes of Wales Hospital, Bridgend, was asked to speak in a short debate at an NATN branch meeting, supporting the motion that 'swab racks are an old fashioned idea'. Although she did not like swab racks she had not attempted thus far to do anything about them. In the event, she actually lost the debate--not in principle but because she could offer no effective alternative method of checking swabs. Having been given the incentive, a trial is now being conducted in her hospital similar to that described by Paul Wicker. This is the case presented by Mary Mumford supporting the following motion ... 'that swab racks are an old fashioned idea, which cause more potential problems due to exposure of blood than is proven to be safe in today's theatre environment'.

CM-2 Environmental/Modal Testing of SPACEHAB Racks

NASA Technical Reports Server (NTRS)

McNelis, Mark E.; Goodnight, Thomas W.

2001-01-01

Combined environmental/modal vibration testing has been implemented at the NASA Glenn Research Center's Structural Dynamics Laboratory. The benefits of combined vibration testing are that it facilitates test article modal characterization and vibration qualification testing. The Combustion Module-2 (CM-2) is a space experiment that will launch on shuttle mission STS-107 in the SPACEHAB Research Double Module. The CM-2 flight hardware is integrated into a SPACEHAB single and double rack. CM-2 rack-level combined vibration testing was recently completed on a shaker table to characterize the structure's modal response and verify the random vibration response. Control accelerometers and limit force gauges, located between the fixture and rack interface, were used to verify the input excitation. Results of the testing were used to verify the loads and environments for flight on the shuttles.

Evaluation of food storage racks available on the Polish market in the hygienic context

PubMed

Grzesińska, Wiesława; Tomaszewska, Marzena; Bilska, Beata; Trafiałek, Joanna; Dziadek, Michał

Providing safe food products to the consumer depends on the material and technology used and adherence to hygienic practices, throughout the production process. The degree of microbial contamination of a surface is an important indicator of equipment cleanliness and effectiveness of cleaning and disinfection. Used material, construction solutions and quality of the applied devices also have an effect on hygienic status. The objective of the present study was to evaluate the influence of the design and construction material of selected food storage racks, available on the Polish market, on their hygienic status. The study was based on determination of the capability of microbial growth on the surface of the racks and the effectiveness of their cleaning. Microbiological cleanliness on the surface of the racks was monitored by the contact plates which are able to estimate the total number of icroorganisms. Examination of effectiveness of cleaning was conducted by the use of ATP bioluminescence method. This experiment has proven a significant influence of adopted construction solutions on the hygienic status of the examined racks. Presence of antibacterial layer and a choice of the appropriate construction material characterized by a low surface roughness impedes the microbial growth and increases the effectiveness of cleaning. Design solutions have significant impact on the hygienic status of shelves. Selection of a suitable material for the construction of racks can greatly reduce the possibility of the development of microorganism, despite the low efficiency of the cleaning. The application of antimicrobial coatings inhibits microbial growth.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Biraud, S. C.; Reichl, K.

The Greenhouse Gas (GhG) Measurement system is a combination of two systems in series: (1) the Tower Gas Processing (TGP) System, an instrument rack which pulls, pressurizes, and dries air streams from an atmospheric sampling tower through a series of control and monitoring components, and (2) the Picarro model G2301 cavity ringdown spectrometer (CRDS), which measures CO2, CH4, and H2O vapor; the primary measurements of the GhG system.

Process Time Refinement for Reusable Launch Vehicle Regeneration Modeling

DTIC Science & Technology

2008-03-01

predicted to fail, or have failed. 3) Augmenting existing space systems with redundant or additional capability to enhance space system performance or...Canopies, External Tanks/Pods/Pylon Ejectors , Armament Bay Doors, Missile Launchers, Wing and Fuselage Center Line Racks, Bomb Bay Release...Systems Test 04583 Thrust Maintenance Operation 04584 Silo Door Operation 04650 Initial Build-up-Recovery Vehicle (RV) 147 04610 Nondestructive

Experimental study on thrust and power of flapping-wing system based on rack-pinion mechanism.

PubMed

Nguyen, Tuan Anh; Vu Phan, Hoang; Au, Thi Kim Loan; Park, Hoon Cheol

2016-06-20

This experimental study investigates the effect of three parameters: wing aspect ratio (AR), wing offset, and flapping frequency, on thrust generation and power consumption of a flapping-wing system based on a rack-pinion mechanism. The new flapping-wing system is simple but robust, and is able to create a large flapping amplitude. The thrust measured by a load cell reveals that for a given power, the flapping-wing system using a higher wing AR produces larger thrust and higher flapping frequency at the wing offset of 0.15[Formula: see text] or 0.20[Formula: see text] ([Formula: see text] is the mean chord) than other wing offsets. Of the three parameters, the flapping frequency plays a more significant role on thrust generation than either the wing AR or the wing offset. Based on the measured thrusts, an empirical equation for thrust prediction is suggested, as a function of wing area, flapping frequency, flapping angle, and wing AR. The difference between the predicted and measured thrusts was less than 7%, which proved that the empirical equation for thrust prediction is reasonable. On average, the measured power consumption to flap the wings shows that 46.5% of the input power is spent to produce aerodynamic forces, 14.0% to overcome inertia force, 9.5% to drive the rack-pinion-based flapping mechanism, and 30.0% is wasted as the power loss of the installed motor. From the power analysis, it is found that the wing with an AR of 2.25 using a wing offset of 0.20[Formula: see text] showed the optimal power loading in the flapping-wing system. In addition, the flapping frequency of 25 Hz is recommended as the optimal frequency of the current flapping-wing system for high efficiency, which was 48.3%, using a wing with an AR of 2.25 and a wing offset of 0.20[Formula: see text] in the proposed design.

40 CFR 63.984 - Fuel gas systems and processes to which storage vessel, transfer rack, or equipment leak...

Code of Federal Regulations, 2010 CFR

2010-07-01

... function in that process; (ii) Transformed by chemical reaction into materials that are not regulated... evaluation (or engineering assessment) that demonstrates the extent to which one or more of the conditions...

14. Forebay structure from hillside to the North. Viewed toward ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

14. Forebay structure from hillside to the North. Viewed toward the South and East (elevated view) showing trash racks and floor plan. HAER, COLO, 23-RIF, V,1D-1 - Havemeyer-Willcox Canal System, Rifle, Garfield County, CO

40 CFR 63.984 - Fuel gas systems and processes to which storage vessel, transfer rack, or equipment leak...

Code of Federal Regulations, 2011 CFR

2011-07-01

... function in that process; (ii) Transformed by chemical reaction into materials that are not regulated... evaluation (or engineering assessment) that demonstrates the extent to which one or more of the conditions...

Data Turbine Activities at NASA

NASA Technical Reports Server (NTRS)

Freudinger, Lawrence C.

2008-01-01

Mission Support Features: a) Shirtsleeve environment, . 18 scientists; b) worldwide deployment experience; c) Extensive modifications to support in-situ and remote sensing instruments 1) zenith and nadir viewports; 2) modified power systems; 3) 19 inch rack mounting; 4) on-board data acquisition network.

Acoustic emissions verification testing of International Space Station experiment racks at the NASA Glenn Research Center Acoustical Testing Laboratory

NASA Astrophysics Data System (ADS)

Akers, James C.; Passe, Paul J.; Cooper, Beth A.

2005-09-01

The Acoustical Testing Laboratory (ATL) at the NASA John H. Glenn Research Center (GRC) in Cleveland, OH, provides acoustic emission testing and noise control engineering services for a variety of specialized customers, particularly developers of equipment and science experiments manifested for NASA's manned space missions. The ATL's primary customer has been the Fluids and Combustion Facility (FCF), a multirack microgravity research facility being developed at GRC for the USA Laboratory Module of the International Space Station (ISS). Since opening in September 2000, ATL has conducted acoustic emission testing of components, subassemblies, and partially populated FCF engineering model racks. The culmination of this effort has been the acoustic emission verification tests on the FCF Combustion Integrated Rack (CIR) and Fluids Integrated Rack (FIR), employing a procedure that incorporates ISO 11201 (``Acoustics-Noise emitted by machinery and equipment-Measurement of emission sound pressure levels at a work station and at other specified positions-Engineering method in an essentially free field over a reflecting plane''). This paper will provide an overview of the test methodology, software, and hardware developed to perform the acoustic emission verification tests on the CIR and FIR flight racks and lessons learned from these tests.

CONSTANS-like 9 (COL9) delays the flowering time in Oryza sativa by repressing the Ehd1 pathway.

PubMed

Liu, Hao; Gu, Fengwei; Dong, Shuangyu; Liu, Wei; Wang, Hui; Chen, Zhiqiang; Wang, Jiafeng

2016-10-14

Flowering or heading is one of most important agronomic traits in rice. It has been characterized that CONSTANS (CO) and CONSTANS-like (COL) proteins are critical flowering regulators in response to photoperiodic stress in plants. We have previously identified that the COL family member OsCOL9 can positively enhance the rice blast resistance. In the present study, we aimed to explore the functional role of OsCOL9 in modulating the photoperiodic flowering. Our data showed that overexpression of OsCOL9 delayed the flowering time under both short-day (SD) and long-day (LD) conditions, leading to suppressed expressions of EHd1, RFT and Hd3a at the mRNA Level. OsCOL9 expression exhibited two types of circadian patterns under different daylight conditions, and it could delay the heading date by suppressing the Ehd1 photoperiodic flowering pathway. In contrast, the expressions of previously reported flowering regulators were not significantly changed in OsCOL9 transgenic plants, indicating that OsCOL9 functioned independently of other flowering pathways. In addition, OsCOL9 served as a potential yield gene, and its deficiency reduced the grain number of main panicle in plants. Furthermore, yeast two-hybrid assay indicated that OsCOL9 physically interacted with Receptor for Activated C-kinase 1 (OsRACK1). Rhythmic pattern analysis suggested that OsRACK1 responded to the change of daylight, which was regulated by the circadian clock. Taken together, our results revealed that OsCOL9 could delay the flowering time in rice by repressing the Ehd1 pathway. Copyright © 2016 The Authors. Published by Elsevier Inc. All rights reserved.

14. DETAILS OF GATE OPERATING MECHANISM, SHOWING RACK SECTION, CUT ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

14. DETAILS OF GATE OPERATING MECHANISM, SHOWING RACK SECTION, CUT TEETH, CAST TEETH, GATE PINION (1907) - Nine Mile Hydroelectric Development, Powerhouse, State Highway 291 along Spokane River, Nine Mile Falls, Spokane County, WA

HANDMADE WOODEN RACK FOR TOOL STORE, LOWER LEVEL OF HYDROELECTRIC ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

HANDMADE WOODEN RACK FOR TOOL STORE, LOWER LEVEL OF HYDROELECTRIC POWER HOUSE - St. Lucie Canal, Lock No. 1, Hydroelectric Power House, St. Lucie, Cross State Canal, Okeechobee Intracoastal Waterway, Stuart, Martin County, FL

Combustion Integrated Rack (CIR) work

NASA Image and Video Library

2014-06-09

ISS040-E-008521 (9 June 2014) --- NASA astronaut Reid Wiseman, Expedition 40 flight engineer, removes and replaces a new manifold bottle in the Combustion Integration Rack (CIR) in the Destiny laboratory of the International Space Station.

29. VIEW OF 4TH FLOOR'S TELEPHONE RACKS WITH CABLE TRAYS ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

29. VIEW OF 4TH FLOOR'S TELEPHONE RACKS WITH CABLE TRAYS ABOVE. THESE ARE NEWER APPARATUS AND NOT ORIGINAL. - Pacific Telephone & Telegraph Company Building, 1519 Franklin Street, Oakland, Alameda County, CA

Microgravity Combustion Science and Fluid Physics Experiments and Facilities for the ISS

NASA Technical Reports Server (NTRS)

Lauver, Richard W.; Kohl, Fred J.; Weiland, Karen J.; Zurawski, Robert L.; Hill, Myron E.; Corban, Robert R.

2001-01-01

At the NASA Glenn Research Center, the Microgravity Science Program supports both ground-based and flight experiment research in the disciplines of Combustion Science and Fluid Physics. Combustion Science research includes the areas of gas jet diffusion flames, laminar flames, burning of droplets and misting fuels, solids and materials flammability, fire and fire suppressants, turbulent combustion, reaction kinetics, materials synthesis, and other combustion systems. The Fluid Physics discipline includes the areas of complex fluids (colloids, gels, foams, magneto-rheological fluids, non-Newtonian fluids, suspensions, granular materials), dynamics and instabilities (bubble and drop dynamics, magneto/electrohydrodynamics, electrochemical transport, geophysical flows), interfacial phenomena (wetting, capillarity, contact line hydrodynamics), and multiphase flows and phase changes (boiling and condensation, heat transfer, flow instabilities). A specialized International Space Station (ISS) facility that provides sophisticated research capabilities for these disciplines is the Fluids and Combustion Facility (FCF). The FCF consists of the Combustion Integrated Rack (CIR), the Fluids Integrated Rack (FIR) and the Shared Accommodations Rack and is designed to accomplish a large number of science investigations over the life of the ISS. The modular, multiuser facility is designed to optimize the science return within the available resources of on-orbit power, uplink/downlink capacity, crew time, upmass/downmass, volume, etc. A suite of diagnostics capabilities, with emphasis on optical techniques, will be provided to complement the capabilities of the subsystem multiuser or principal investigator-specific experiment modules. The paper will discuss the systems concept, technical capabilities, functionality, and the initial science investigations in each discipline.

Development of driver’s assistant system of additional visual information of blind areas for Gazelle Next

NASA Astrophysics Data System (ADS)

Makarov, V.; Korelin, O.; Koblyakov, D.; Kostin, S.; Komandirov, A.

2018-02-01

The article is devoted to the development of the Advanced Driver Assistance Systems (ADAS) for the GAZelle NEXT car. This project is aimed at developing a visual information system for the driver integrated into the windshield racks. The developed system implements the following functions: assistance in maneuvering and parking; Recognition of road signs; Warning the driver about the possibility of a frontal collision; Control of "blind" zones; "Transparent" vision in the windshield racks, widening the field of view, behind them; Visual and sound information about the traffic situation; Control and descent from the lane of the vehicle; Monitoring of the driver’s condition; navigation system; All-round review. The scheme of action of sensors of the developed system of visual information of the driver is provided. The moments of systems on a prototype of a vehicle are considered. Possible changes in the interior and dashboard of the car are given. The results of the implementation are aimed at the implementation of the system - improved informing of the driver about the environment and the development of an ergonomic interior for this system within the new Functional Salon of the Gazelle Next vehicle equipped with a visual information system for the driver.

Development and testing of the rack insertion device

NASA Technical Reports Server (NTRS)

Strickland, G. Scott

1995-01-01

Installing and removing experiment racks in a Space Station Logistics Module will become a repetitive operation at Kennedy Space Center (KSC) in the near future. A Rack Insertion Device (RID) consisting of an Extendible Boom, End Effector, and Positioning Base is being developed for the task. This paper discusses the key elements of the RlD's function and design. Prototype test results for the RlD's Extendible Boom and End Effector are presented. Also discussed are future end effectors that will further enhance the RlD's Space Station processing capability.

Metal-driven and covalent synthesis of supramolecular grids from racks: a convergent approach to heterometallic and heteroleptic nanostructures.

PubMed

Schmittel, Michael; Kalsani, Venkateshwarlu; Bats, Jan W

2005-06-13

Supramolecular nanogrids were prepared from dynamic supramolecular racks through the coupling of terminal alkynes using either a covalent (with CuCl/O(2)) or a coordinative (with [trans-(PEt(3))(2)PtCl(2)]) approach. Because of the rapid equilibration of the racks (as tested by exchange reactions), oligomeric adducts potentially formed in the coupling process will selectively furnish the nanogrids through an entropically driven self-repair mechanism. To ascertain the structural assignment, the nanogrids were also synthesized by an independent strategy.

Carbon Dioxide Dispersion in the Combustion Integrated Rack Simulated Numerically

NASA Technical Reports Server (NTRS)

Wu, Ming-Shin; Ruff, Gary A.

2004-01-01

When discharged into an International Space Station (ISS) payload rack, a carbon dioxide (CO2) portable fire extinguisher (PFE) must extinguish a fire by decreasing the oxygen in the rack by 50 percent within 60 sec. The length of time needed for this oxygen reduction throughout the rack and the length of time that the CO2 concentration remains high enough to prevent the fire from reigniting is important when determining the effectiveness of the response and postfire procedures. Furthermore, in the absence of gravity, the local flow velocity can make the difference between a fire that spreads rapidly and one that self-extinguishes after ignition. A numerical simulation of the discharge of CO2 from PFE into the Combustion Integrated Rack (CIR) in microgravity was performed to obtain the local velocity and CO2 concentration. The complicated flow field around the PFE nozzle exits was modeled by sources of equivalent mass and momentum flux at a location downstream of the nozzle. The time for the concentration of CO2 to reach a level that would extinguish a fire anywhere in the rack was determined using the Fire Dynamics Simulator (FDS), a computational fluid dynamics code developed by the National Institute of Standards and Technology specifically to evaluate the development of a fire and smoke transport. The simulation shows that CO2, as well as any smoke and combustion gases produced by a fire, would be discharged into the ISS cabin through the resource utility panel at the bottom of the rack. These simulations will be validated by comparing the results with velocity and CO2 concentration measurements obtained during the fire suppression system verification tests conducted on the CIR in March 2003. Once these numerical simulations are validated, portions of the ISS labs and living areas will be modeled to determine the local flow conditions before, during, and after a fire event. These simulations can yield specific information about how long it takes for smoke and combustion gases produced by a fire to reach a detector location, how large the fire would be when the detector alarms, and the behavior of the fire until it has been extinguished. This new capability could then be used to optimize the location of fire detectors and fire-suppression ports as well as to evaluate the effectiveness of fire suppressants and response strategies. Numerical data collected from these simulations could also be used to develop a virtual reality fire event for crew training and fire safety awareness. This work is funded by NASA's Bioastronautics Initiative, which has the objective of ensuring and enhancing the health, safety, and performance of humans in space. As part of this initiative, the Microgravity Combustion Science Branch at the NASA Glenn Research Center is conducting spacecraft fire safety research to significantly improve fire safety on inhabited spacecraft.

Nuclear import of transcription factor BR-C is mediated by its interaction with RACK1.

PubMed

Cheng, Daojun; Qian, Wenliang; Wang, Yonghu; Meng, Meng; Wei, Ling; Li, Zhiqing; Kang, Lixia; Peng, Jian; Xia, Qingyou

2014-01-01

The transcription factor Broad Complex (BR-C) is an early ecdysone response gene in insects and contains two types of domains: two zinc finger domains for the activation of gene transcription and a Bric-a-brac/Tramtrack/Broad complex (BTB) domain for protein-protein interaction. Although the mechanism of zinc finger-mediated gene transcription is well studied, the partners interacting with the BTB domain of BR-C has not been elucidated until now. Here, we performed a yeast two-hybrid screen using the BTB domain of silkworm BR-C as bait and identified the receptor for activated C-kinase 1 (RACK1), a scaffolding/anchoring protein, as the novel partner capable of interacting with BR-C. The interaction between BR-C and RACK1 was further confirmed by far-western blotting and pull-down assays. Importantly, the disruption of this interaction, via RNAi against the endogenous RACK1 gene or deletion of the BTB domain, abolished the nuclear import of BR-C in BmN4 cells. In addition, RNAi against the endogenous PKC gene as well as phosphorylation-deficient mutation of the predicted PKC phosphorylation sites at either Ser373 or Thr406 in BR-C phenocopied RACK1 RNAi and altered the nuclear localization of BR-C. However, when BTB domain was deleted, phosphorylation mimics of either Ser373 or Thr406 had no effect on the nuclear import of BR-C. Moreover, mutating the PKC phosphorylation sites at Ser373 and Thr406 or deleting the BTB domain significantly decreased the transcriptional activation of a BR-C target gene. Given that RACK1 is necessary for recruiting PKC to close and phosphorylate target proteins, we suggest that the PKC-mediated phosphorylation and nuclear import of BR-C is determined by its interaction with RACK1. This novel finding will be helpful for further deciphering the mechanism underlying the role of BR-C proteins during insect development.

Nuclear Import of Transcription Factor BR-C Is Mediated by Its Interaction with RACK1

PubMed Central

Wang, Yonghu; Meng, Meng; Wei, Ling; Li, Zhiqing; Kang, Lixia; Peng, Jian; Xia, Qingyou

2014-01-01

The transcription factor Broad Complex (BR-C) is an early ecdysone response gene in insects and contains two types of domains: two zinc finger domains for the activation of gene transcription and a Bric-a-brac/Tramtrack/Broad complex (BTB) domain for protein-protein interaction. Although the mechanism of zinc finger-mediated gene transcription is well studied, the partners interacting with the BTB domain of BR-C has not been elucidated until now. Here, we performed a yeast two-hybrid screen using the BTB domain of silkworm BR-C as bait and identified the receptor for activated C-kinase 1 (RACK1), a scaffolding/anchoring protein, as the novel partner capable of interacting with BR-C. The interaction between BR-C and RACK1 was further confirmed by far-western blotting and pull-down assays. Importantly, the disruption of this interaction, via RNAi against the endogenous RACK1 gene or deletion of the BTB domain, abolished the nuclear import of BR-C in BmN4 cells. In addition, RNAi against the endogenous PKC gene as well as phosphorylation-deficient mutation of the predicted PKC phosphorylation sites at either Ser373 or Thr406 in BR-C phenocopied RACK1 RNAi and altered the nuclear localization of BR-C. However, when BTB domain was deleted, phosphorylation mimics of either Ser373 or Thr406 had no effect on the nuclear import of BR-C. Moreover, mutating the PKC phosphorylation sites at Ser373 and Thr406 or deleting the BTB domain significantly decreased the transcriptional activation of a BR-C target gene. Given that RACK1 is necessary for recruiting PKC to close and phosphorylate target proteins, we suggest that the PKC-mediated phosphorylation and nuclear import of BR-C is determined by its interaction with RACK1. This novel finding will be helpful for further deciphering the mechanism underlying the role of BR-C proteins during insect development. PMID:25280016

View of FE Stott installing hardware on the Fluids Integrated Rack (FIR)

NASA Image and Video Library

2009-10-22

ISS021-E-011438 (22 Oct. 2009) --- NASA astronaut Nicole Stott, Expedition 21 flight engineer, installs hardware in the Fluids Integrated Rack (FIR) in the Destiny laboratory of the International Space Station.

View of FE Stott installing hardware on the Fluids Integrated Rack (FIR)

NASA Image and Video Library

2009-10-22

ISS021-E-011443 (22 Oct. 2009) --- NASA astronaut Nicole Stott, Expedition 21 flight engineer, installs hardware in the Fluids Integrated Rack (FIR) in the Destiny laboratory of the International Space Station.

View of FE Stott installing hardware on the Fluids Integrated Rack (FIR)

NASA Image and Video Library

2009-10-22

ISS021-E-011440 (22 Oct. 2009) --- NASA astronaut Nicole Stott, Expedition 21 flight engineer, installs hardware in the Fluids Integrated Rack (FIR) in the Destiny laboratory of the International Space Station.

Materials Science Research Rack-1 (MSRR-1)

NASA Technical Reports Server (NTRS)

2001-01-01

This scale model depicts the Materials Science Research Rack-1 (MSRR-1) being developed by NASA's Marshall Space Flight Center and the European Space Agency (ESA) for placement in the Destiny laboratory module aboard the International Space Station. The rack is part of the plarned Materials Science Research Facility (MSRF) and is expected to include two furnace module inserts, a Quench Module Insert (being developed by NASA's Marshall Space Flight Center) to study directional solidification in rapidly cooled alloys and a Diffusion Module Insert (being developed by the European Space Agency) to study crystal growth, and a transparent furnace (being developed by NASA's Space Product Development program). Multi-user equipment in the rack is being developed under the auspices of NASA's Office of Biological and Physical Research (OBPR) and ESA. Key elements are labeled in other images (0101754, 0101829, 0101830, and TBD). This image is from a digital still camera; higher resolution is not available.

Materials Science Research Rack-1 (MSRR-1)

NASA Technical Reports Server (NTRS)

2001-01-01

This scale model depicts the Materials Science Research Rack-1 (MSRR-1) being developed by NASA's Marshall Space Flight Center and the European Space Agency (ESA) for placement in the Destiny laboratory module aboard the International Space Station. The rack is part of the plarned Materials Science Research Facility (MSRF) and is expected to include two furnace module inserts, a Quench Module Insert (being developed by NASA's Marshall Space Flight Center) to study directional solidification in rapidly cooled alloys and a Diffusion Module Insert (being developed by the European Space Agency) to study crystal growth, and a transparent furnace (being developed by NASA's Space Product Development program). Multi-user equipment in the rack is being developed under the auspices of NASA's Office of Biological and Physical Research (OBPR) and ESA. Here the transparent furnace is extracted for servicing. Key elements are labeled in other images (0101754, 0101829, 0101830, and TBD).

Materials Science Research Rack-1 (MSRR-1)

NASA Technical Reports Server (NTRS)

2001-01-01

This scale model depicts the Materials Science Research Rack-1 (MSRR-1) being developed by NASA's Marshall Space Flight Center and the European Space Agency (ESA) for placement in the Destiny laboratory module aboard the International Space Station. The rack is part of the plarned Materials Science Research Facility (MSRF) and is expected to include two furnace module inserts, a Quench Module Insert (being developed by NASA's Marshall Space Flight Center) to study directional solidification in rapidly cooled alloys and a Diffusion Module Insert (being developed by the European Space Agency) to study crystal growth, and a transparent furnace (being developed by NASA's Space Product Development program). Multi-user equipment in the rack is being developed under the auspices of NASA's Office of Biological and Physical Research (OBPR) and ESA. Key elements are labeled in other images (0101754, 0101829, and TBD). This composite is from a digital still camera; higher resolution is not available.

KSC-05PD-0371

NASA Technical Reports Server (NTRS)

2005-01-01

KENNEDY SPACE CENTER, FLA. In the Space Station Processing Facility, the Human Research Facility-2 (HRF-2) science rack is attached to the Rack Insertion Device that will install it into the Multi-Purpose Logistics Module Raffaello (at left) for flight on Space Shuttle Discoverys Return to Flight mission, STS-114. The HRF-2 will deliver additional biomedical instrumentation and research capability to the International Space Station. HRF-1, installed on the U.S. Lab since May 2001, contains an ultrasound unit and gas analyzer. Both racks provide structural, power, thermal, command and data handling, and communication and tracking interfaces between the HRF biomedical instrumentation and the U.S. Laboratory, Destiny. NASA Kennedy Space Center and their prime contractor responsible for ISS element processing, The Boeing Company, prepared the rack for installation. The HRF Project is managed by NASA Johnson Space Center and implemented through contract with Lockheed Martin, Houston, Texas.

KSC-05PD-0374

NASA Technical Reports Server (NTRS)

2005-01-01

KENNEDY SPACE CENTER, FLA. In the Space Station Processing Facility, a worker watches as the Rack Insertion Device slowly moves the Human Research Facility-2 (HRF-2) science rack into the Multi-Purpose Logistics Module Raffaello for flight on Space Shuttle Discoverys Return to Flight mission, STS-114. The HRF-2 will deliver additional biomedical instrumentation and research capability to the International Space Station. HRF-1, installed on the U.S. Lab since May 2001, contains an ultrasound unit and gas analyzer. Both racks provide structural, power, thermal, command and data handling, and communication and tracking interfaces between the HRF biomedical instrumentation and the U.S. Laboratory, Destiny. NASA Kennedy Space Center and their prime contractor responsible for ISS element processing, The Boeing Company, prepared the rack for installation. The HRF Project is managed by NASA Johnson Space Center and implemented through contract with Lockheed Martin, Houston, Texas.

KSC-05PD-0370

NASA Technical Reports Server (NTRS)

2005-01-01

KENNEDY SPACE CENTER, FLA. In the Space Station Processing Facility, workers prepare to attach the Human Research Facility-2 (HRF-2) science rack onto the Rack Insertion Device. HRF-2 will be installed into the Multi-Purpose Logistics Module Raffaello (at left) for flight on Space Shuttle Discoverys Return to Flight mission, STS-114. The HRF-2 will deliver additional biomedical instrumentation and research capability to the International Space Station. HRF-1, installed on the U.S. Lab since May 2001, contains an ultrasound unit and gas analyzer. Both racks provide structural, power, thermal, command and data handling, and communication and tracking interfaces between the HRF biomedical instrumentation and the U.S. Laboratory, Destiny. NASA Kennedy Space Center and their prime contractor responsible for ISS element processing, The Boeing Company, prepared the rack for installation. The HRF Project is managed by NASA Johnson Space Center and implemented through contract with Lockheed Martin, Houston, Texas.

KSC-05PD-0373

NASA Technical Reports Server (NTRS)

2005-01-01

KENNEDY SPACE CENTER, FLA. In the Space Station Processing Facility, a worker stands by as the Rack Insertion Device slowly moves the Human Research Facility-2 (HRF-2) science rack into the Multi-Purpose Logistics Module Raffaello for flight on Space Shuttle Discoverys Return to Flight mission, STS-114. The HRF-2 will deliver additional biomedical instrumentation and research capability to the International Space Station. HRF-1, installed on the U.S. Lab since May 2001, contains an ultrasound unit and gas analyzer. Both racks provide structural, power, thermal, command and data handling, and communication and tracking interfaces between the HRF biomedical instrumentation and the U.S. Laboratory, Destiny. NASA Kennedy Space Center and their prime contractor responsible for ISS element processing, The Boeing Company, prepared the rack for installation. The HRF Project is managed by NASA Johnson Space Center and implemented through contract with Lockheed Martin, Houston, Texas.

Laboratory glassware rack for seismic safety

NASA Technical Reports Server (NTRS)

Cohen, M. M. (Inventor)

1985-01-01

A rack for laboratory bottles and jars for chemicals and medicines has been designed to provide the maximum strength and security to the glassware in the event of a significant earthquake. The rack preferably is rectangular and may be made of a variety of chemically resistant materials including polypropylene, polycarbonate, and stainless steel. It comprises a first plurality of parallel vertical walls, and a second plurality of parallel vertical walls, perpendicular to the first. These intersecting vertical walls comprise a self-supporting structure without a bottom which sits on four legs. The top surface of the rack is formed by the top edges of all the vertical walls, which are not parallel but are skewed in three dimensions. These top edges form a grid matrix having a number of intersections of the vertical walls which define a number of rectangular compartments having varying widths and lengths and varying heights.

KENNEDY SPACE CENTER, FLA. - Japanese astronaut Koichi Wakata (left) works with a tray extended from inside the Pressurized Module, or PM, part of the Japanese Experiment Module (JEM). The PM provides a shirt-sleeve environment in which astronauts on the International Space Station can conduct microgravity experiments. There are a total of 23 racks, including 10 experiment racks, inside the PM providing a power supply, communications, air conditioning, hardware cooling, water control and experiment support functions.

NASA Image and Video Library

2003-09-24

KENNEDY SPACE CENTER, FLA. - Japanese astronaut Koichi Wakata (left) works with a tray extended from inside the Pressurized Module, or PM, part of the Japanese Experiment Module (JEM). The PM provides a shirt-sleeve environment in which astronauts on the International Space Station can conduct microgravity experiments. There are a total of 23 racks, including 10 experiment racks, inside the PM providing a power supply, communications, air conditioning, hardware cooling, water control and experiment support functions.

KENNEDY SPACE CENTER, FLA. - In the Space Station Processing Facility, Japanese astronaut Koichi Wakata looks over the Pressurized Module, or PM, part of the Japanese Experiment Module (JEM). The PM provides a shirt-sleeve environment in which astronauts on the International Space Station can conduct microgravity experiments. There are a total of 23 racks, including 10 experiment racks, inside the PM providing a power supply, communications, air conditioning, hardware cooling, water control and experiment support functions.

NASA Image and Video Library

2003-09-24

KENNEDY SPACE CENTER, FLA. - In the Space Station Processing Facility, Japanese astronaut Koichi Wakata looks over the Pressurized Module, or PM, part of the Japanese Experiment Module (JEM). The PM provides a shirt-sleeve environment in which astronauts on the International Space Station can conduct microgravity experiments. There are a total of 23 racks, including 10 experiment racks, inside the PM providing a power supply, communications, air conditioning, hardware cooling, water control and experiment support functions.

KENNEDY SPACE CENTER, FLA. - In the Space Station Processing Facility, technicians on the floor watch as a tray is extended from inside the Pressurized Module, or PM, part of the Japanese Experiment Module (JEM). The PM provides a shirt-sleeve environment in which astronauts on the International Space Station can conduct microgravity experiments. There are a total of 23 racks, including 10 experiment racks, inside the PM providing a power supply, communications, air conditioning, hardware cooling, water control and experiment support functions.

NASA Image and Video Library

2003-09-24

KENNEDY SPACE CENTER, FLA. - In the Space Station Processing Facility, technicians on the floor watch as a tray is extended from inside the Pressurized Module, or PM, part of the Japanese Experiment Module (JEM). The PM provides a shirt-sleeve environment in which astronauts on the International Space Station can conduct microgravity experiments. There are a total of 23 racks, including 10 experiment racks, inside the PM providing a power supply, communications, air conditioning, hardware cooling, water control and experiment support functions.

KENNEDY SPACE CENTER, FLA. - Japanese astronaut Koichi Wakata (right) works with a tray extended from inside the Pressurized Module, or PM, part of the Japanese Experiment Module (JEM). The PM provides a shirt-sleeve environment in which astronauts on the International Space Station can conduct microgravity experiments. There are a total of 23 racks, including 10 experiment racks, inside the PM providing a power supply, communications, air conditioning, hardware cooling, water control and experiment support functions.

NASA Image and Video Library

2003-09-24

KENNEDY SPACE CENTER, FLA. - Japanese astronaut Koichi Wakata (right) works with a tray extended from inside the Pressurized Module, or PM, part of the Japanese Experiment Module (JEM). The PM provides a shirt-sleeve environment in which astronauts on the International Space Station can conduct microgravity experiments. There are a total of 23 racks, including 10 experiment racks, inside the PM providing a power supply, communications, air conditioning, hardware cooling, water control and experiment support functions.

Conditional VHL Gene Deletion Causes Hypoglycemic Death Associated with Disproportionately Increased Glucose Uptake by Hepatocytes through an Upregulated IGF-I Receptor

PubMed Central

Kurabayashi, Atsushi; Kakinuma, Yoshihiko; Morita, Taku; Inoue, Keiji; Sato, Takayuki; Furihata, Mutsuo

2013-01-01

Our conditional VHL knockout (VHL-KO) mice, having VHL gene deletion induced by tamoxifen, developed severe hypoglycemia associated with disproportionately increased storage of PAS-positive substances in the liver and resulted in the death of these mice. This hypoglycemic state was neither due to impaired insulin secretion nor insulin receptor hypersensitivity. By focusing on insulin-like growth factor I (IGF-I), which has a similar effect on glucose metabolism as the insulin receptor, we demonstrated that IGF-I receptor (IGF-IR) protein expression in the liver was upregulated in VHL-KO mice compared to that in the mice without VHL deletion, as was the expression of glucose transporter (GLUT) 1. The interaction of the receptor for activated C kinase (RACK) 1, which predominantly binds to VHL, was enhanced in VHL-KO livers with IGF-IR, because VHL deletion increased free RACK1 and facilitated the IGF-IR-RACKI interaction. An IGF-IR antagonist retarded hypoglycemic progression and sustained an euglycemic state. These IGF-IR antagonist effects on restoring blood glucose levels also attenuated PAS-positive substance storage in the liver. Because the effect of IGF-I on HIF-1α protein synthesis is mediated by IGF-IR, our results indicated that VHL inactivation accelerated hepatic glucose storage through the upregulation of IGF-IR and GLUT1 and that IGF-IR was a key regulator in VHL-deficient hepatocytes. PMID:23874892

Toward IVHM Prognostics

NASA Technical Reports Server (NTRS)

Walsh, Kevin; Venti, Mike

2007-01-01

This viewgraph presentation reviews the prognostics of Integrated Vehicle Health Management. The contents include: 1) Aircraft Operations-Today's way of doing business; 2) Prognostics; 3) NASA's instrumentation data-system rack; 4) Data mining for IVHM; 5) NASA GRC's C-MAPSS generic engine model; and 6) Concluding thoughts.

Optical Atomic Clock for Fundamental Physics and Precision Metrology in Space

NASA Astrophysics Data System (ADS)

Williams, Jason; Le, Thanh; Kulas, Sascha; Yu, Nan

2017-04-01

The maturity of optical atomic clocks (OC), which operate at optical frequencies for higher quality-factor as compared to their microwave counterparts, has rapidly progressed to the point where lab-based systems now outperform the record cesium clocks by orders of magnitude in both accuracy and stability. We will present our efforts to develop a strontium optical clock testbed at JPL, aimed towards extending the exceptional performance demonstrated by OCs from state-of-the-art laboratory designs to a transportable instrument that can fit within the space and power constraints of e.g. a single express rack onboard the International Space Station. The overall technology will find applications for future fundamental physics research, both on ground and in space, precision time keeping, and NASA/JPL time and frequency test capabilities. This research was carried out at the Jet Propulsion Laboratory, California Institute of Technology, under a contract with the National Aeronautics and Space Administration.

Experiment/facility requirements document for the Space Station Furnace Facility. Section 1: Integrated configuration

NASA Astrophysics Data System (ADS)

1992-05-01

The function of the Space Station Furnace Facility (SSFF) is to support materials research into the crystal growth and solidification processes of electronic and photonic materials, metals and alloys, and glasses and ceramics. To support this broad base of research requirements, the SSFF will employ a variety of furnace modules which will be operated, regulated, and supported by a core of common subsystems. Furnace modules may be reconfigured or specifically developed to provide unique solidification conditions for each set of experiments. The SSFF modular approach permits the addition of new or scaled-up furnace modules to support the evolution of the facility as new science requirements are identified. The SSFF Core is of modular design to permit augmentation for enhanced capabilities. The fully integrated configuration of the SSFF will consist of three racks with the capability of supporting up to two furnace modules per rack. The initial configuration of the SSFF will consist of two of the three racks and one furnace module. This Experiment/Facility Requirements Document (E/FRD) describes the integrated facility requirements for the Space Station Freedom (SSF) Integrated Configuration-1 (IC1) mission. The IC1 SSFF will consist of two racks: the Core Rack, with the centralized subsystem equipment; and the Experiment Rack-1, with Furnace Module-1 and the distributed subsystem equipment to support the furnace. The SSFF support functions are provided by the following Core subsystems: power conditioning and distribution subsystem (SSFF PCDS); data management subsystem (SSFF DMS); thermal control Subsystem (SSFF TCS); gas distribution subsystem (SSFF GDS); and mechanical structures subsystem (SSFF MSS).

Experiment/facility requirements document for the Space Station Furnace Facility. Section 1: Integrated configuration

NASA Technical Reports Server (NTRS)

1992-01-01

The function of the Space Station Furnace Facility (SSFF) is to support materials research into the crystal growth and solidification processes of electronic and photonic materials, metals and alloys, and glasses and ceramics. To support this broad base of research requirements, the SSFF will employ a variety of furnace modules which will be operated, regulated, and supported by a core of common subsystems. Furnace modules may be reconfigured or specifically developed to provide unique solidification conditions for each set of experiments. The SSFF modular approach permits the addition of new or scaled-up furnace modules to support the evolution of the facility as new science requirements are identified. The SSFF Core is of modular design to permit augmentation for enhanced capabilities. The fully integrated configuration of the SSFF will consist of three racks with the capability of supporting up to two furnace modules per rack. The initial configuration of the SSFF will consist of two of the three racks and one furnace module. This Experiment/Facility Requirements Document (E/FRD) describes the integrated facility requirements for the Space Station Freedom (SSF) Integrated Configuration-1 (IC1) mission. The IC1 SSFF will consist of two racks: the Core Rack, with the centralized subsystem equipment; and the Experiment Rack-1, with Furnace Module-1 and the distributed subsystem equipment to support the furnace. The SSFF support functions are provided by the following Core subsystems: power conditioning and distribution subsystem (SSFF PCDS); data management subsystem (SSFF DMS); thermal control Subsystem (SSFF TCS); gas distribution subsystem (SSFF GDS); and mechanical structures subsystem (SSFF MSS).

Implications of Natural Occlusion of Ventilated Racks on Ammonia and Sanitation Practices

PubMed Central

Creamer, Michelle A; Petty, Joann; Martin, Tara; Bergdall, Valerie; Hickman-Davis, Judy M

2014-01-01

Examination of ventilated rat racks prior to semiannual sanitation revealed silicone nozzles and ventilation ports that were partially or completely occluded with granular debris. We subsequently sought to document performance standards for rack sanitation and investigate the effect of ventilation port occlusion on rack function and animal husbandry practices. We hypothesized that individually ventilated cages with occluded airflow would require more frequent cage changes, comparable to those for static cages (that is, every 3 to 4 d). Sprague–Dawley rats were housed under one of 4 conditions: no airflow occlusion, occluded air-supply inlet, occluded air-exhaust outlet, and occlusion of both inlet and outlet. Cages were changed when daily ammonia concentration exceeded 20 ppm or after 14 d had elapsed. Most cages with unoccluded or partial airflow occlusion remained below the 20 ppm limit until day 12 or 13. Cages with occlusion of both inlet and outlet exceeded 20 ppm ammonia by as early as day 5. Airflow was significantly lower in cages with occlusion of both inlet and outlet airflow. Weekly inspection revealed that occlusion of ventilation ports was detectable by 3 mo after semiannual sanitation. This study demonstrates that silicone nozzles should be removed prior to rack sanitation to improve the effectiveness of cleaning ventilation ports and nozzles. While the rack is in use, silicone nozzles and ventilation ports should be inspected regularly to identify occlusion that is likely to diminish environmental quality in the cage. Intracage ammonia levels are significantly higher when both inlet and outlet airflow are occluded. PMID:24602544

Implications of natural occlusion of ventilated racks on ammonia and sanitation practices.

PubMed

Creamer, Michelle A; Petty, Joann; Martin, Tara; Bergdall, Valerie; Hickman-Davis, Judy M

2014-03-01

Examination of ventilated rat racks prior to semiannual sanitation revealed silicone nozzles and ventilation ports that were partially or completely occluded with granular debris. We subsequently sought to document performance standards for rack sanitation and investigate the effect of ventilation port occlusion on rack function and animal husbandry practices. We hypothesized that individually ventilated cages with occluded airflow would require more frequent cage changes, comparable to those for static cages (that is, every 3 to 4 d). Sprague-Dawley rats were housed under one of 4 conditions: no airflow occlusion, occluded air-supply inlet, occluded air-exhaust outlet, and occlusion of both inlet and outlet. Cages were changed when daily ammonia concentration exceeded 20 ppm or after 14 d had elapsed. Most cages with unoccluded or partial airflow occlusion remained below the 20 ppm limit until day 12 or 13. Cages with occlusion of both inlet and outlet exceeded 20 ppm ammonia by as early as day 5. Airflow was significantly lower in cages with occlusion of both inlet and outlet airflow. Weekly inspection revealed that occlusion of ventilation ports was detectable by 3 mo after semiannual sanitation. This study demonstrates that silicone nozzles should be removed prior to rack sanitation to improve the effectiveness of cleaning ventilation ports and nozzles. While the rack is in use, silicone nozzles and ventilation ports should be inspected regularly to identify occlusion that is likely to diminish environmental quality in the cage. Intracage ammonia levels are significantly higher when both inlet and outlet airflow are occluded.

STS-100 MPLM Raffaello is moved to the payload canister

NASA Technical Reports Server (NTRS)

2001-01-01

KENNEDY SPACE CENTER, Fla. - Workers inside the payload canister wait for the Multi-Purpose Logistics Module Raffaello to be lowered inside. It joins the Canadian robotic arm, SSRMS, already in place. Both elements are part of the payload on mission STS- 100 to the International Space Station. Raffaello carries six system racks and two storage racks for the U.S. Lab. The arm has seven motorized joints and is capable of handling large payloads and assisting with docking the Space Shuttle. The SSRMS is self- relocatable with a Latching End Effector so it can be attached to complementary ports spread throughout the Station'''s exterior surfaces. Launch of STS-100 is scheduled for April 19, 2001 at 2:41 p.m. EDT from Launch Pad 39A.

U.S. Rep. Dave Weldon looks at the U.S. Lab Destiny in the SSPF.

NASA Technical Reports Server (NTRS)

1999-01-01

Inside the U.S. Lab, called 'Destiny,' which is in the Space Station Processing Facility, U.S. Rep. Dave Weldon (right) looks over equipment. In the background (center) is Thomas R. 'Randy' Galloway, with the Space Station Hardware Integration Office. Weldon is on the House Science Committee and vice chairman of the Space and Aeronautics Subcommittee. Destiny is scheduled to be launched on Space Shuttle Endeavour in early 2000. It will become the centerpiece of scientific research on the ISS, with five equipment racks aboard to provide essential functions for station systems, including high data-rate communications, and to maintain the station's orientation using control gyroscopes launched earlier. Additional equipment and research racks will be installed in the laboratory on subsequent Shuttle flights.

KSC01pp0539

NASA Image and Video Library

2001-02-24

Members of the STS-100 crew check out Endeavour inside the Orbiter Processing Facility bay 2. In their blue uniforms, they are (front to back) Commander Kent V. Rominger, Pilot Jeff rey S. Ashby, and Mission Specialists Yuri Lonchakov, who is with the Russian Aviation and Space Agency, and Chris Hadfield, who is with the Canadian Space Agency. Other crew members at KSC for the CEIT are Mission Specialists Scott Parazynski and Umberto Guidoni, who is with the European Space Agency. Endeavour is carrying the Multi-Purpose Logistics Module Raffaello and the Canadian robotic arm, SSRMS, to the International Space Station. Raffaello carries six system racks and two storage racks for the U.S. Lab. Launch of mission STS-100 is scheduled for April 19 at 2:41 p.m. EDT from Launch Pad 39A

KSC-01pp1423

NASA Image and Video Library

2001-08-06

KENNEDY SPACE CENTER, Fla. -- On Launch Pad 39A, workers check out the loading of the payloads into Discovery’s payload bay. In the center is the Multi-Purpose Logistics Module Leonardo, filled with laboratory racks of science equipment and racks and platforms of experiments and supplies. Above Leonardo is the Integrated Cargo Carrier with the Early Ammonia Servicer (EAS) in the center. The EAS contains spare ammonia for the Station’s cooling system. Ammonia is the fluid used in the radiators that cool the Station’s electronics. The EAS will be installed on the P6 truss holding the giant U.S. solar arrays, batteries and cooling radiators. Seen below the MPLM and attached on the port and starboard adapter beams are experiments. Discovery is scheduled to be launched Aug. 9, 2001

U.S. Rep. Dave Weldon outside the U.S. Lab Destiny in the SSPF.

NASA Technical Reports Server (NTRS)

1999-01-01

In the Space Station Processing Facility, U.S. Rep Dave Weldon (at left) looks at the U.S. Lab, called Destiny. With him are Thomas R. 'Randy' Galloway, with the Space Station Hardware Integration Office, Dana Gartzke, the congressman's chief of staffm and Boeing workers. Weldon is on the House Science Committee and vice chairman of the Space and Aeronautics Subcommittee. Destiny is scheduled to be launched on Space Shuttle Endeavour in early 2000. It will become the centerpiece of scientific research on the ISS, with five equipment racks aboard to provide essential functions for station systems, including high data-rate communications, and to maintain the station's orientation using control gyroscopes launched earlier. Additional equipment and research racks will be installed in the laboratory on subsequent Shuttle flights.

U.S. Rep. Dave Weldon looks at the U.S. Lab Destiny in the SSPF.

NASA Technical Reports Server (NTRS)

1999-01-01

In the Space Station Processing Facility, U.S. Rep. Dave Weldon (center) looks over the U.S. Laboratory, called 'Destiny,' with a group of Boeing workers. Behind (left) the congressman is Dana Gartzke, the congressman's chief of staff. Weldon is on the House Science Committee and vice chairman of the Space and Aeronautics Subcommittee. Destiny, which will become the centerpiece of scientific research on the ISS, will have five equipment racks aboard to provide essential functions for station systems, including high data-rate communications, and to maintain the station's orientation using control gyroscopes launched earlier. Additional equipment and research racks will be installed in the laboratory on subsequent Shuttle flights. Destiny is scheduled to be launched on Space Shuttle Endeavour in early 2000.

GreenChill Store Certification Protocol for Sub-Cooling Contained on Racks Separate from Refrigeration Equipment

EPA Pesticide Factsheets

Document describes the protocol used to determine the total load and refrigerant charge of stores that have placed all sub-cooling on a rack separate from all other commercial refrigeration equipment.

9 CFR 91.27 - Troughs and hayracks.

Code of Federal Regulations, 2010 CFR

2010-01-01

... as provided in this section. Racks or nets furnished for feeding hay shall be of a type acceptable to... hay from racks or nets or by placing the hay on the floor of the pens in which the animals are...

9 CFR 590.547 - Albumen flake process drying operations.

Code of Federal Regulations, 2010 CFR

2010-01-01

... free of flies, insects, and rodents. (b) Drying units, racks, and trucks shall be kept in a clean and sanitary condition. (c) Drying pans, trays, belts, scrapers, or curing racks, if used, shall be kept in a...

75 FR 44818 - Advisory Committee on Reactor Safeguards (ACRS); Meeting of the ACRS Subcommittee on ESBWR

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-29

...-Drop and Thermal-Hydraulic Analysis for ESBWR Fuel Racks,'' NEDC- 33374P, ``Safety Analysis Report for Fuel Storage Racks Criticality Analysis for ESBWR Plants,'' NEDE-33083P, ``TRACG Application for ESBWR...

Development of a Simulation Capability for the Space Station Active Rack Isolation System

NASA Technical Reports Server (NTRS)

Johnson, Terry L.; Tolson, Robert H.

1998-01-01

To realize quality microgravity science on the International Space Station, many microgravity facilities will utilize the Active Rack Isolation System (ARIS). Simulation capabilities for ARIS will be needed to predict the microgravity environment. This paper discusses the development of a simulation model for use in predicting the performance of the ARIS in attenuating disturbances with frequency content between 0.01 Hz and 10 Hz. The derivation of the model utilizes an energy-based approach. The complete simulation includes the dynamic model of the ISPR integrated with the model for the ARIS controller so that the entire closed-loop system is simulated. Preliminary performance predictions are made for the ARIS in attenuating both off-board disturbances as well as disturbances from hardware mounted onboard the microgravity facility. These predictions suggest that the ARIS does eliminate resonant behavior detrimental to microgravity experimentation. A limited comparison is made between the simulation predictions of ARIS attenuation of off-board disturbances and results from the ARIS flight test. These comparisons show promise, but further tuning of the simulation is needed.

International Space Station USOS Waste and Hygiene Compartment Development

NASA Technical Reports Server (NTRS)

Link, Dwight E., Jr.; Broyan, James Lee, Jr.; Gelmis, Karen; Philistine, Cynthia; Balistreri, Steven

2007-01-01

The International Space Station (ISS) currently provides human waste collection and hygiene facilities in the Russian Segment Service Module (SM) which supports a three person crew. Additional hardware is planned for the United States Operational Segment (USOS) to support expansion of the crew to six person capability. The additional hardware will be integrated in an ISS standard equipment rack structure that was planned to be installed in the Node 3 element; however, the ISS Program Office recently directed implementation of the rack, or Waste and Hygiene Compartment (WHC), into the U.S. Laboratory element to provide early operational capability. In this configuration, preserved urine from the WHC waste collection system can be processed by the Urine Processor Assembly (UPA) in either the U.S. Lab or Node 3 to recover water for crew consumption or oxygen production. The human waste collection hardware is derived from the Service Module system and is provided by RSC-Energia. This paper describes the concepts, design, and integration of the WHC waste collection hardware into the USOS including integration with U.S. Lab and Node 3 systems.

International Space Station USOS Crew Quarters Development

NASA Technical Reports Server (NTRS)

Broyan, James Lee, Jr.; Borrego, Melissa Ann; Bahr, Juergen F.

2008-01-01

The International Space Station (ISS) United States Operational Segment (USOS) currently provides a Temporary Sleep Station (TeSS) as crew quarters for one crewmember in the Laboratory Module. The Russian Segment provides permanent crew quarters (Kayutas) for two crewmembers in the Service Module. The TeSS provides limited electrical, communication, and ventilation functionality. A new permanent rack sized USOS ISS Crew Quarters (CQ) is being developed. Up to four CQs can be installed into the Node 2 element to increase the ISS crewmember size to six. The new CQs will provide private crewmember space with enhanced acoustic noise mitigation, integrated radiation reduction material, controllable airflow, communication equipment, redundant electrical systems, and redundant caution and warning systems. The rack sized CQ is a system with multiple crewmember restraints, adjustable lighting, controllable ventilation, and interfaces that allow each crewmember to personalize their CQ workspace. Providing an acoustically quiet and visually isolated environment, while ensuring crewmember safety, is critical for obtaining crewmember rest and comfort to enable long term crewmember performance. The numerous human factor, engineering, and program considerations during the concept, design, and prototyping are outlined in the paper.