Reconstruction of the evolution of microbial defense systems.

PubMed

Puigbò, Pere; Makarova, Kira S; Kristensen, David M; Wolf, Yuri I; Koonin, Eugene V

2017-04-04

Evolution of bacterial and archaeal genomes is a highly dynamic process that involves intensive loss of genes as well as gene gain via horizontal transfer, with a lesser contribution from gene duplication. The rates of these processes can be estimated by comparing genomes that are linked by an evolutionary tree. These estimated rates of genome dynamics events substantially differ for different functional classes of genes. The genes involved in defense against viruses and other invading DNA are among those that are gained and lost at the highest rates. We employed a stochastic birth-and-death model to obtain maximum likelihood estimates of the rates of gain and loss of defense genes in 35 groups of closely related bacterial genomes and one group of archaeal genomes. We find that on average, the defense genes experience 1.4 fold higher flux than the rest of microbial genes. This excessive flux of defense genes over the genomic mean is consistent across diverse microbial groups. The few exceptions include intracellular parasites with small, degraded genomes that possess few defense systems which are more stable than in other microbes. Generally, defense genes follow the previously established pattern of genome dynamics, with gene family loss being about 3 times more common than gain and an order of magnitude more common than expansion or contraction of gene families. Case by case analysis of the evolutionary dynamics of defense genes indicates frequent multiple events in the same locus and widespread involvement of mobile elements in the gain and loss of defense genes. Evolution of microbial defense systems is highly dynamic but, notwithstanding the host-parasite arms race, generally follows the same trends that have been established for the rest of the genes. Apart from the paucity and the low flux of defense genes in parasitic bacteria with deteriorating genomes, there is no clear connection between the evolutionary regime of defense systems and microbial life style.

Review of the all Source Analysis System as a Part of the Audit of the Effectiveness of the Defense Acquisition Board Review Process-FY 1993.

DTIC Science & Technology

1993-04-20

OFFICE OF THE INSPECTOR GENERAL REVIEW OF THE ALL SOURCE ANALYSIS SYSTEM AS A PART OF THE AUDIT OF THE EFFECTIVENESS OF THE DEFENSE...System as a Part of the Audit of the Effectiveness of the Defense Acquisition Board Review Process--FY 1993 (Report No. 93-087) We are providing...appreciate the courtesies extended to the audit staff. If you have questions on this report, please contact Program Director Russell A. Rau at (703) 693

An Analysis of Turkey’s Defense Systems Acquisition Policy

DTIC Science & Technology

2009-03-01

i NAVAL POSTGRADUATE SCHOOL MONTEREY, CALIFORNIA MBA PROFESSIONAL REPORT An Analysis of Turkey’s Defense Systems Acquisition...2009 3. REPORT TYPE AND DATES COVERED MBA THESIS 4. TITLE AND SUBTITLE An Analysis of Turkey’s Defense Systems Acquisition Policy 6. AUTHOR(S...DISTRIBUTION CODE 13. ABSTRACT (maximum 200 words) The purpose of this MBA thesis is to analyze Turkey’s defense systems acquisition policy and

Depth Perception and Defensive System Activation in a 3-D Environment

PubMed Central

Combe, Emmanuelle; Fujii, Naotaka

2011-01-01

To survive, animals must be able to react appropriately (in temporal and behavioral terms) when facing a threat. One of the essential parameters considered by the defensive system is the distance of the threat, the “defensive distance.” In this study, we investigate the visual depth cues that could be considered as an alarm cue for the activation of the defensive system. For this purpose, we performed an active-escape pain task in a virtual three-dimensional environment. In two experiments, we manipulated the nature and consistency of different depth cues: vergence, linear perspective, and angular size. By measuring skin conductance responses, we characterized the situations that activated the defensive system. We show that the angular size of the predator was sufficient information to trigger responses from the defensive system, but we also demonstrate that vergence, which can delay the emotional response in inconsistent situations, is also a highly reliable cue for the activation of the defensive system. PMID:21941515

The Evolution of the Contract Type Used in Defense Acquisition with a Focus on Major Defense Weapon Systems

DTIC Science & Technology

2012-09-01

III. THE DEFENSE MARKETPLACE A. DEFENSE INDUSTRY OVERVIEW The market of the defense industry in the United States is different than the commercial...marketplace in a number of respects. Lorell, Lowell, Kennedy, and Levaux (2000) defined the uniqueness of the U.S. defense market in two ways. First...the U.S. defense market for weapon systems is characterized by a single buyer (Lorell et al., 2000, p. 13). “The second distinguishing feature of

Defense system shortcuts and limits of scope.

PubMed

Rewald, E; Francischetti, M M

2000-10-01

Defense, as a key factor of life, shares the biological tendencies of simplicity and energy saving. We propose that, like the mind, defense tends to rely on shortcuts via immune memes. Also, response repetition may induce the formation of virtual 'modules' [toolkits] to simplify and perfect performance. Engaged modules may expand by proliferating or by capturing immune components from the 'dormant' and even perhaps from active ones. With regard to recovery and/or survival, complexity of the integrated defense system (IDS) (1) requires to be inside of what we call the 'functional window'. In contrast to the physiological and common disease repair, energy is squandered when IDS perceives real danger. Our concern is the uncertain transition to conditions that do not fit into the IDS routine and, even worse, that are outside the functional window where the system is lacking. Copyright 2000 Harcourt Publishers Ltd.

The Science and Technology of the US National Missile Defense System

NASA Astrophysics Data System (ADS)

Postol, Theodore A.

2010-03-01

The National Missile Defense System utilizes UHF and X-band radars for search, track and discrimination, and interceptors that use long-wave infrared sensors to identify and home on attacking warheads. The radars and infrared sensors in the missile defense system perform at near the theoretical limits predicted by physics. However, in spite of the fantastic technical advances in sensor technology, signal processing, and computational support functions, the National Missile Defense System cannot be expected to ever work in realistic combat environments. This talk will describe why these impressive technologies can never deliver on the promise of a credible defense against long-range ballistic missiles.

Defense Enterprise Accounting and Management System-Increment 1 (DEAMS Inc 1)

DTIC Science & Technology

2016-03-01

information accurately and in conformance with Generally Accepted Accounting Principles , to comply with Congressional requirements of the Chief Financial ...2016 Major Automated Information System Annual Report Defense Enterprise Accounting and Management System-Increment 1 (DEAMS Inc 1) Defense...Phone: 937-257-2714 Fax: DSN Phone: 787-2714 DSN Fax: Date Assigned: August 17, 2015 Program Information Program Name Defense Enterprise Accounting

Extending the Basal. Learning Package No. 13.

ERIC Educational Resources Information Center

Collins, Norma; Smith, Carl, Comp.

Originally developed for the Department of Defense Schools (DoDDS) system, this learning package on extending the basal is designed for teachers who wish to upgrade or expand their teaching skills on their own. The package includes a comprehensive search of the ERIC database; a lecture giving an overview on the topic; the full text of several…

32 CFR 232.4 - Terms of consumer credit extended to covered borrowers.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 32 National Defense 2 2012-07-01 2012-07-01 false Terms of consumer credit extended to covered... DEFENSE (CONTINUED) MISCELLANEOUS LIMITATIONS ON TERMS OF CONSUMER CREDIT EXTENDED TO SERVICE MEMBERS AND DEPENDENTS § 232.4 Terms of consumer credit extended to covered borrowers. (a) Neither a creditor who extends...

32 CFR 232.4 - Terms of consumer credit extended to covered borrowers.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 32 National Defense 2 2011-07-01 2011-07-01 false Terms of consumer credit extended to covered... DEFENSE (CONTINUED) MISCELLANEOUS LIMITATIONS ON TERMS OF CONSUMER CREDIT EXTENDED TO SERVICE MEMBERS AND DEPENDENTS § 232.4 Terms of consumer credit extended to covered borrowers. (a) Neither a creditor who extends...

32 CFR 232.4 - Terms of consumer credit extended to covered borrowers.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 32 National Defense 2 2010-07-01 2010-07-01 false Terms of consumer credit extended to covered... DEFENSE (CONTINUED) MISCELLANEOUS LIMITATIONS ON TERMS OF CONSUMER CREDIT EXTENDED TO SERVICE MEMBERS AND DEPENDENTS § 232.4 Terms of consumer credit extended to covered borrowers. (a) Neither a creditor who extends...

DEFENSE RTD&E ONLINE SYSTEM (DROLS)

EPA Science Inventory

Web Enabled DROLS (WED) is a free subscription service available to registered users that provides online access to DTIC's Technical Reports and Research Summaries Databases. It replaces the former unclassified dial-up access to DROLS, DTIC's Defense RDT&E Online System. The Defe...

75 FR 32635 - Defense Acquisition Regulations System; Defense Federal Acquisition Regulation Supplement...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-08

... Regulations System; Defense Federal Acquisition Regulation Supplement; Balance of Payments Program Exemption... implement the exemption from the Balance of Payments Program for construction material that is commercial... is proposing to amend the DFARS to implement in the clauses at 252.225-7044, Balance of Payments...

The species recognition system: a new corollary for the human fetoembryonic defense system hypothesis.

PubMed

Clark, G F; Dell, A; Morris, H R; Patankar, M S; Easton, R L

2001-01-01

We have previously suggested that the human fetus is protected during human development by a system of both soluble and cell surface associated glycoconjugates that utilize their carbohydrate sequences as functional groups to enable them to evoke tolerance. The proposed model has been referred to as the human fetoembryonic defense system hypothesis (hu-FEDS). In this paradigm, it has previously been proposed that similar oligosaccharides are used to mediate crucial recognition events required during both human sperm-egg binding and immune-inflammatory cell interactions. This vertical integration suggested to us that the sperm-egg binding itself is related to universal recognition events that occur between immune and inflammatory cells, except that in this case recognition of 'species' rather than recognition of 'self' is being manifested. In this paper, we have designated this component of hu-FEDS as the species recognition system (SRS). We propose that the SRS is an integral component of the hu-FEDS used to enable sperm-egg recognition and protection of the gametes from potential immune responses. Recent structural data indicates that the glycan sequences implicated in mediating murine gamete recognition are also expressed on CD45 in activated murine T lymphocytes and cytotoxic T lymphocytes. This overlap supports our contention that there is an overlap between the immune and gamete recognition systems. Therefore the hu-FEDS paradigm may be a subset of a larger model that also applies to other placental mammals. We therefore propose that the hu-FEDS model for protection should in the future be referred to as the eutherian fetoembryonic defense system hypothesis (eu-FEDS) to account for this extension. The possibility exists that the SRS component of eu-FEDS could predate eutherians and extend to all sexually reproducing organisms. Future investigation of the interactions between the immune and gamete recognition system will be required to determine the degree of

75 FR 71560 - Defense Federal Acquisition Regulation Supplement; Cost and Software Data Reporting System (DFARS...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-24

... DEPARTMENT OF DEFENSE Defense Acquisition Regulations System 48 CFR Parts 215, 234, 242, and 252... System (DFARS Case 2008-D027) AGENCY: Defense Acquisition Regulations System, Department of Defense (DoD... 1921-2, Progress Curve Report Comment: A respondent noted that DD Form 1921-2 Progress Curve Report...

75 FR 3178 - Defense Federal Acquisition Regulation Supplement; Lead System Integrators

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-20

... Government procurement. Amy G. Williams, Editor, Defense Acquisition Regulations System. 0 Accordingly, the..., without change, an interim rule amending the Defense Federal Acquisition Regulation Supplement (DFARS) to... limitations on the award of new contracts for lead system integrator functions in the acquisition of major DoD...

System justification and the defense of committed relationship ideology.

PubMed

Day, Martin V; Kay, Aaron C; Holmes, John G; Napier, Jaime L

2011-08-01

A consequential ideology in Western society is the uncontested belief that a committed relationship is the most important adult relationship and that almost all people want to marry or seriously couple (DePaulo & Morris, 2005). In the present article, we investigated the extent to which the system justification motive may contribute to the adoption of this ideology. In Studies 1 and 2, we examined whether a heightened motive to maintain the status quo would increase defense of committed relationship values. In Study 3, we examined the reverse association, that is, whether a threat to committed relationship ideology would also affect sociopolitical system endorsement. As past research has found that the justification of political systems depends upon how much these systems are perceived as controlling, in Study 4 we tested whether the defense of the system of committed relationships would also increase when framed as controlling. Results from Studies 1-4 were consistent with our hypotheses, but only for men. In Study 5, using cross-cultural data, we sought to replicate these findings correlationally and probe for a cause of the gender effect. Results from more than 33,000 respondents indicated a relationship (for men) between defense of the sociopolitical system and defense of marriage in countries where the traditional advantages of men over women were most threatened. In Studies 6 and 7, we investigated when this gender difference disappears. Results revealed that when we measured (Study 6) or manipulated (Study 7) personal relationship identity rather than relationship ideology, effects also emerge for women.

Study on combat effectiveness of air defense missile weapon system based on queuing theory

NASA Astrophysics Data System (ADS)

Zhao, Z. Q.; Hao, J. X.; Li, L. J.

2017-01-01

Queuing Theory is a method to analyze the combat effectiveness of air defense missile weapon system. The model of service probability based on the queuing theory was constructed, and applied to analyzing the combat effectiveness of "Sidewinder" and "Tor-M1" air defense missile weapon system. Finally aimed at different targets densities, the combat effectiveness of different combat units of two types' defense missile weapon system is calculated. This method can be used to analyze the usefulness of air defense missile weapon system.

Defense Systems Management Review. Volume I, Number 4. Autumn 1977

DTIC Science & Technology

1977-10-03

quarterly by the Defense Systems Management College, Fort Belvoir, VA 22060. Publication of the Review was approved by OASD(PA) May 18 1976. The views...Two copies of reprinted material should be forwarded to the Editor. Distribution of this publication is controlled. Inquiries concerning...DESTBIBUTION STATEMENT A Approved for public release; ■Distribution Unlimited in DEFENSE SYSTEMS MANAGEMENT REVIEW PURPOSE The purpose of the

32 CFR 21.200 - What is the Defense Grant and Agreement Regulatory System (DGARS)?

Code of Federal Regulations, 2014 CFR

2014-07-01

... 32 National Defense 1 2014-07-01 2014-07-01 false What is the Defense Grant and Agreement Regulatory System (DGARS)? 21.200 Section 21.200 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE DoD GRANT AND AGREEMENT REGULATIONS DoD GRANTS AND AGREEMENTS-GENERAL MATTERS Defense...

32 CFR 21.200 - What is the Defense Grant and Agreement Regulatory System (DGARS)?

Code of Federal Regulations, 2011 CFR

2011-07-01

... 32 National Defense 1 2011-07-01 2011-07-01 false What is the Defense Grant and Agreement Regulatory System (DGARS)? 21.200 Section 21.200 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE DoD GRANT AND AGREEMENT REGULATIONS DoD GRANTS AND AGREEMENTS-GENERAL MATTERS Defense...

32 CFR 21.200 - What is the Defense Grant and Agreement Regulatory System (DGARS)?

Code of Federal Regulations, 2010 CFR

2010-07-01

... 32 National Defense 1 2010-07-01 2010-07-01 false What is the Defense Grant and Agreement Regulatory System (DGARS)? 21.200 Section 21.200 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE DoD GRANT AND AGREEMENT REGULATIONS DoD GRANTS AND AGREEMENTS-GENERAL MATTERS Defense...

32 CFR 21.200 - What is the Defense Grant and Agreement Regulatory System (DGARS)?

Code of Federal Regulations, 2012 CFR

2012-07-01

... 32 National Defense 1 2012-07-01 2012-07-01 false What is the Defense Grant and Agreement Regulatory System (DGARS)? 21.200 Section 21.200 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE DoD GRANT AND AGREEMENT REGULATIONS DoD GRANTS AND AGREEMENTS-GENERAL MATTERS Defense...

32 CFR 21.200 - What is the Defense Grant and Agreement Regulatory System (DGARS)?

Code of Federal Regulations, 2013 CFR

2013-07-01

... 32 National Defense 1 2013-07-01 2013-07-01 false What is the Defense Grant and Agreement Regulatory System (DGARS)? 21.200 Section 21.200 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE DoD GRANT AND AGREEMENT REGULATIONS DoD GRANTS AND AGREEMENTS-GENERAL MATTERS Defense...

Semantic Web and Inferencing Technologies for Department of Defense Systems

DTIC Science & Technology

2014-10-01

contact report for a specific type of aircraft . Intra-domain-specific metadata in the threat data domain might be used to categorize the contact...DEFENSE SYSTEMS by Duane Davis October 2014 Approved for public release; distribution is unlimited Prepared for: The NPS Center for Multi-INT...TITLE AND SUBTITLE Semantic Web and Inferencing Technologies for Department of Defense Systems 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c

Defense Occupational and Environmental Health Readiness System (DOEHRS) Guidance

DTIC Science & Technology

2009-07-01

TERMS Defense Occupational and Environmental Health Reporting System (DOEHRS), Industrial Hygiene, Environmental Health, Information Management System Hygiene...Information System (AF EMIS), the Air Force Enterprise Environmental, Safety, and Occupational Health Information Management System (EESOH MIS), or the

Prophage-mediated defense against viral attack and viral counter-defense

PubMed Central

Dedrick, Rebekah M.; Jacobs-Sera, Deborah; Guerrero Bustamante, Carlos A.; Garlena, Rebecca A.; Mavrich, Travis N.; Pope, Welkin H.; Reyes, Juan C Cervantes; Russell, Daniel A.; Adair, Tamarah; Alvey, Richard; Bonilla, J. Alfred; Bricker, Jerald S.; Brown, Bryony R.; Byrnes, Deanna; Cresawn, Steven G.; Davis, William B.; Dickson, Leon A.; Edgington, Nicholas P.; Findley, Ann M.; Golebiewska, Urszula; Grose, Julianne H.; Hayes, Cory F.; Hughes, Lee E.; Hutchison, Keith W.; Isern, Sharon; Johnson, Allison A.; Kenna, Margaret A.; Klyczek, Karen K.; Mageeney, Catherine M.; Michael, Scott F.; Molloy, Sally D.; Montgomery, Matthew T.; Neitzel, James; Page, Shallee T.; Pizzorno, Marie C.; Poxleitner, Marianne K.; Rinehart, Claire A.; Robinson, Courtney J.; Rubin, Michael R.; Teyim, Joseph N.; Vazquez, Edwin; Ware, Vassie C.; Washington, Jacqueline; Hatfull, Graham F.

2017-01-01

Temperate phages are common and prophages are abundant residents of sequenced bacterial genomes. Mycobacteriophages are viruses infecting mycobacterial hosts including Mycobacterium tuberculosis and Mycobacterium smegmatis, encompass substantial genetic diversity, and are commonly temperate. Characterization of ten Cluster N temperate mycobacteriophages reveals at least five distinct prophage-expressed viral defense systems that interfere with infection of lytic and temperate phages that are either closely-related (homotypic defense) or unrelated (heterotypic defense). Target specificity is unpredictable, ranging from a single target phage to one-third of those tested. The defense systems include a single-subunit restriction system, a heterotypic exclusion system, and a predicted (p)ppGpp synthetase, which blocks lytic phage growth, promotes bacterial survival, and enables efficient lysogeny. The predicted (p)ppGpp synthetase coded by the Phrann prophage defends against phage Tweety infection, but Tweety codes for a tetrapeptide repeat protein, gp54, that acts as a highly effective counter-defense system. Prophage-mediated viral defense offers an efficient mechanism for bacterial success in host-virus dynamics, and counter-defense promotes phage co-evolution. PMID:28067906

Defense Primer: The National Defense Budget Function (050)

DTIC Science & Technology

2017-03-17

in parenthesis). This defense primer addresses the National Defense Budget (050), which is frequently used to explain trends in military spending...but which also includes some activities not conducted by the Department of Defense. What Is the Purpose of the Budget Function System? The budget

Harnessing the Prokaryotic Adaptive Immune System as a Eukaryotic Antiviral Defense

PubMed Central

Price, Aryn A.; Grakoui, Arash; Weiss, David S.

2016-01-01

Clustered, regularly interspaced, short palindromic repeats - CRISPR associated (CRISPR-Cas) systems are sequence specific RNA-directed endonuclease complexes that bind and cleave nucleic acids. These systems evolved within prokaryotes as adaptive immune defenses to target and degrade nucleic acids derived from bacteriophages and other foreign genetic elements. The antiviral function of these systems has now been exploited to combat eukaryotic viruses throughout the viral life cycle. Here we discuss current advances in CRISPR-Cas9 technology as a eukaryotic antiviral defense. PMID:26852268

Effects of internal and external factors on the budgeting between defensive and non-defensive responses in Aplysia.

PubMed

Leod, Kaitlyn A Mac; Seas, Alexandra; Wainwright, Marcy L; Mozzachiodi, Riccardo

2018-04-25

Following exposure to aversive stimuli, organisms budget their behaviors by augmenting defensive responses and reducing/suppressing non-defensive behaviors. This budgeting process must be flexible to accommodate modifications in the animal's internal and/or external state that require the normal balance between defensive and non-defensive behaviors to be adjusted. When exposed to aversive stimuli, the mollusk Aplysia budgets its behaviors by concurrently enhancing defensive withdrawal reflexes (an elementary form of learning known as sensitization) and suppressing feeding. Sensitization and feeding suppression are consistently co-expressed following different training protocols and share common temporal domains, suggesting that they are interlocked. In this study, we attempted to uncouple the co-expression of sensitization and feeding suppression using: 1) manipulation of the animal's motivational state through prolonged food deprivation and 2) extended training with aversive stimuli that induces sensitization lasting for weeks. Both manipulations uncoupled the co-expression of the above behavioral changes. Prolonged food deprivation prevented the expression of sensitization, but not of feeding suppression. Following the extended training, sensitization and feeding suppression were co-expressed only for a limited time (i.e., 24 h), after which feeding returned to baseline levels as sensitization persisted for up to seven days. These findings indicate that sensitization and feeding suppression are not interlocked and that their co-expression can be uncoupled by internal (prolonged food deprivation) and external (extended aversive training) factors. The different strategies, by which the co-expression of sensitization and feeding suppression was altered, provide an example of how budgeting strategies triggered by an identical aversive experience can vary depending on the state of the organism. Copyright © 2018 Elsevier B.V. All rights reserved.

Alaskan Air Defense and Early Warning Systems Clear Air ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Alaskan Air Defense and Early Warning Systems - Clear Air Force Station, Ballistic Missile Early Warning System Site II, One mile west of mile marker 293.5 on Parks Highway, 5 miles southwest of Anderson, Anderson, Denali Borough, AK

Natural History of Innate Host Defense Peptides.

PubMed

Linde, A; Wachter, B; Höner, O P; Dib, L; Ross, C; Tamayo, A R; Blecha, F; Melgarejo, T

2009-12-01

Host defense peptides act on the forefront of innate immunity, thus playing a central role in the survival of animals and plants. Despite vast morphological changes in species through evolutionary history, all animals examined to date share common features in their innate immune defense strategies, hereunder expression of host defense peptides (HDPs). Most studies on HDPs have focused on humans, domestic and laboratory animals. More than a thousand different sequences have been identified, yet data on HDPs in wild-living animals are sparse. The biological functions of HDPs include broad-spectrum antimicrobial activity and immunomodulation. Natural selection and coevolutionary host-pathogen arms race theory suggest that the extent and specificity of the microbial load influences the spectrum and potency of HDPs in different species. Individuals of extant species-that have lived for an extended period in evolutionary history amid populations with intact processes of natural selection-likely possess the most powerful and well-adapted "natural antibiotics". Research on the evolutionary history of the innate defense system and the host in context of the consequences of challenges as well as the efficacy of the innate immune system under natural conditions is therefore of immediate interest. This review focuses on evolutionary aspects of immunophysiology, with emphasis on innate effector molecules. Studies on host defense in wild-living animals may significantly enhance our understanding of inborn immune mechanisms, and help identify molecules that may assist us to cope better with the increasing microbial challenges that likely follow from the continuous amplification of biodiversity levels on Earth.

77 FR 30361 - Defense Federal Acquisition Regulation Supplement; Defense Trade Cooperation Treaty With the...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-22

... DEPARTMENT OF DEFENSE Defense Acquisitions Regulations System 48 CFR Parts 225 and 252 RIN 0750... United Kingdom (DFARS 2012-D034) AGENCY: Defense Acquisition Regulations System; Department of Defense... Acquisition Regulations System, Attn: (Insert case manager's name), OUSD (AT&L) DPAP/DARS, Room 3B855, 3060...

Defense Logistics Standard Systems Functional Requirements.

DTIC Science & Technology

1987-03-01

Artificial Intelligence - the development of a machine capability to perform functions normally concerned with human intelligence, such as learning , adapting...Basic Data Base Machine Configurations .... ......... D- 18 xx ~ ?f~~~vX PART I: MODELS - DEFENSE LOGISTICS STANDARD SYSTEMS FUNCTIONAL REQUIREMENTS...On-line, Interactive Access. Integrating user input and machine output in a dynamic, real-time, give-and- take process is considered the optimum mode

32 CFR 37.1025 - Must I report information to the Defense Assistance Awards Data System?

Code of Federal Regulations, 2010 CFR

2010-07-01

... 32 National Defense 1 2010-07-01 2010-07-01 false Must I report information to the Defense Assistance Awards Data System? 37.1025 Section 37.1025 National Defense Department of Defense OFFICE OF THE... Award Reporting Information About the Award § 37.1025 Must I report information to the Defense...

32 CFR 37.1025 - Must I report information to the Defense Assistance Awards Data System?

Code of Federal Regulations, 2014 CFR

2014-07-01

... 32 National Defense 1 2014-07-01 2014-07-01 false Must I report information to the Defense Assistance Awards Data System? 37.1025 Section 37.1025 National Defense Department of Defense OFFICE OF THE... Award Reporting Information About the Award § 37.1025 Must I report information to the Defense...

32 CFR 37.1025 - Must I report information to the Defense Assistance Awards Data System?

Code of Federal Regulations, 2012 CFR

2012-07-01

... 32 National Defense 1 2012-07-01 2012-07-01 false Must I report information to the Defense Assistance Awards Data System? 37.1025 Section 37.1025 National Defense Department of Defense OFFICE OF THE... Award Reporting Information About the Award § 37.1025 Must I report information to the Defense...

32 CFR 37.1025 - Must I report information to the Defense Assistance Awards Data System?

Code of Federal Regulations, 2013 CFR

2013-07-01

... 32 National Defense 1 2013-07-01 2013-07-01 false Must I report information to the Defense Assistance Awards Data System? 37.1025 Section 37.1025 National Defense Department of Defense OFFICE OF THE... Award Reporting Information About the Award § 37.1025 Must I report information to the Defense...

32 CFR 37.1025 - Must I report information to the Defense Assistance Awards Data System?

Code of Federal Regulations, 2011 CFR

2011-07-01

... 32 National Defense 1 2011-07-01 2011-07-01 false Must I report information to the Defense Assistance Awards Data System? 37.1025 Section 37.1025 National Defense Department of Defense OFFICE OF THE... Award Reporting Information About the Award § 37.1025 Must I report information to the Defense...

Lyapunov modes in extended systems.

PubMed

Yang, Hong-Liu; Radons, Günter

2009-08-28

Hydrodynamic Lyapunov modes, which have recently been observed in many extended systems with translational symmetry, such as hard sphere systems, dynamic XY models or Lennard-Jones fluids, are nowadays regarded as fundamental objects connecting nonlinear dynamics and statistical physics. We review here our recent results on Lyapunov modes in extended system. The solution to one of the puzzles, the appearance of good and 'vague' modes, is presented for the model system of coupled map lattices. The structural properties of these modes are related to the phase space geometry, especially the angles between Oseledec subspaces, and to fluctuations of local Lyapunov exponents. In this context, we report also on the possible appearance of branches splitting in the Lyapunov spectra of diatomic systems, similar to acoustic and optical branches for phonons. The final part is devoted to the hyperbolicity of partial differential equations and the effective degrees of freedom of such infinite-dimensional systems.

The Missile Defense Agency's space tracking and surveillance system

NASA Astrophysics Data System (ADS)

Watson, John; Zondervan, Keith

2008-10-01

The Ballistic Missile Defense System (BMDS) is a layered system incorporating elements in space. In addition to missile warning systems at geosynchronous altitudes, an operational BMDS will include a low Earth orbit (LEO) system-the Space Tracking and Surveillance System (STSS). It will use infrared sensing technologies synergistically with the Space Based Infrared Systems (SBIRS) and will provide a seamless adjunct to radars and sensors on the ground and in airborne platforms. STSS is being designed for a future operational capability to defend against evolving threats. STSS development is divided into phases, commencing with a two-satellite demonstration constellation scheduled for launch in 2008. The demonstration satellites will conduct a menu of tests and experiments to prove the system concept, including the ground segment. They will have limited operational capability within the integrated BMDS. Data from the demonstration satellites will be received and processed by the Missile Defense Space Experiment Center (MDSEC), a part of the Missile Defense Integration and Operations Center (MDIOC). MDA launched in 2007 into LEO a satellite (NFIRE) designed to make near-field multispectral measurements of boosting targets and to demonstrate laser communication, the latter in conjunction with the German satellite TerraSAR-X. The gimbaled, lightweight laser terminal has demonstrated on orbit a 5.5 gbps rate in both directions. The filter passbands of NFIRE are similar to the STSS demonstrator track sensor. While providing useful phenomenology during its time on orbit, NFIRE will also serve as a pathfinder in the development of STSS operations procedures.

Evolution of System Safety at NASA as Related to Defense-in-Depth

NASA Technical Reports Server (NTRS)

Dezfuli, Homayoon

2015-01-01

Presentation given at the Defense-in-Depth Inter-Agency Workshop on August 26, 2015 in Rockville, MD by Homayoon Dezfuli. The presentation addresses the evolution of system safety at NASA as related to Defense-in-Depth.

Risk Assessment Using The Homeland-Defense Operational Planning System (HOPS)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Price, D E; Durling, R L

2005-10-10

The Homeland-Defense Operational Planning System (HOPS), is a new operational planning tool leveraging Lawrence Livermore National Laboratory's expertise in weapons systems and in sparse information analysis to support the defense of the U.S. homeland. HOPS provides planners with a basis to make decisions to protect against acts of terrorism, focusing on the defense of facilities critical to U.S. infrastructure. Criticality of facilities, structures, and systems is evaluated on a composite matrix of specific projected casualty, economic, and sociopolitical impact bins. Based on these criteria, significant unidentified vulnerabilities are identified and secured. To provide insight into potential successes by malevolent actors,more » HOPS analysts strive to base their efforts mainly on unclassified open-source data. However, more cooperation is needed between HOPS analysts and facility representatives to provide an advantage to those whose task is to defend these facilities. Evaluated facilities include: refineries, major ports, nuclear power plants and other nuclear licensees, dams, government installations, convention centers, sports stadiums, tourist venues, and public and freight transportation systems. A generalized summary of analyses of U.S. infrastructure facilities will be presented.« less

Jasmonic acid and salicylic acid activate a common defense system in rice.

PubMed

Tamaoki, Daisuke; Seo, Shigemi; Yamada, Shoko; Kano, Akihito; Miyamoto, Ayumi; Shishido, Hodaka; Miyoshi, Seika; Taniguchi, Shiduku; Akimitsu, Kazuya; Gomi, Kenji

2013-06-01

Jasmonic acid (JA) and salicylic acid (SA) play important roles in plant defense systems. JA and SA signaling pathways interact antagonistically in dicotyledonous plants, but, the status of crosstalk between JA and SA signaling is unknown in monocots. Our rice microarray analysis showed that more than half of the genes upregulated by the SA analog BTH are also upregulated by JA, suggesting that a major portion of the SA-upregulated genes are regulated by JA-dependent signaling in rice. A common defense system that is activated by both JA and SA is thus proposed which plays an important role in pathogen defense responses in rice.

Towards an integrated defense system for cyber security situation awareness experiment

NASA Astrophysics Data System (ADS)

Zhang, Hanlin; Wei, Sixiao; Ge, Linqiang; Shen, Dan; Yu, Wei; Blasch, Erik P.; Pham, Khanh D.; Chen, Genshe

2015-05-01

In this paper, an implemented defense system is demonstrated to carry out cyber security situation awareness. The developed system consists of distributed passive and active network sensors designed to effectively capture suspicious information associated with cyber threats, effective detection schemes to accurately distinguish attacks, and network actors to rapidly mitigate attacks. Based on the collected data from network sensors, image-based and signals-based detection schemes are implemented to detect attacks. To further mitigate attacks, deployed dynamic firewalls on hosts dynamically update detection information reported from the detection schemes and block attacks. The experimental results show the effectiveness of the proposed system. A future plan to design an effective defense system is also discussed based on system theory.

Systemic bacterial infection and immune defense phenotypes in Drosophila melanogaster.

PubMed

Khalil, Sarah; Jacobson, Eliana; Chambers, Moria C; Lazzaro, Brian P

2015-05-13

The fruit fly Drosophila melanogaster is one of the premier model organisms for studying the function and evolution of immune defense. Many aspects of innate immunity are conserved between insects and mammals, and since Drosophila can readily be genetically and experimentally manipulated, they are powerful for studying immune system function and the physiological consequences of disease. The procedure demonstrated here allows infection of flies by introduction of bacteria directly into the body cavity, bypassing epithelial barriers and more passive forms of defense and allowing focus on systemic infection. The procedure includes protocols for the measuring rates of host mortality, systemic pathogen load, and degree of induction of the host immune system. This infection procedure is inexpensive, robust and quantitatively repeatable, and can be used in studies of functional genetics, evolutionary life history, and physiology.

System Support/Sustainment Plan Platform for the Defense Enterprise Accounting Management System (DEAMS)

DTIC Science & Technology

2006-12-01

warfighters requirements and identifies system performance short-comings over its life cycle. 15. NUMBER OF PAGES 89 14. SUBJECT TERMS Information...the system performs to warfighters requirements and identifies system performance short-comings over its life cycle. vi...3 II. DEFENSE ACQUISITION LIFE CYCLE CURRENT STAGE ANALYSIS.......5 A. INTRODUCTION

Strategic Defense Initiative: Splendid Defense or Pipe Dream? Headline Series No. 275.

ERIC Educational Resources Information Center

Armstrong, Scott; Grier, Peter

This pamphlet presents a discussion of the various components of President Reagan's Strategic Defense Initiative (SDI) including the problem of pulling together various new technologies into an effective defensive system and the politics of the so-called "star wars" system. An important part of the defense initiative is the…

Multiple operating system rotation environment moving target defense

DOE Office of Scientific and Technical Information (OSTI.GOV)

Evans, Nathaniel; Thompson, Michael

Systems and methods for providing a multiple operating system rotation environment ("MORE") moving target defense ("MTD") computing system are described. The MORE-MTD system provides enhanced computer system security through a rotation of multiple operating systems. The MORE-MTD system increases attacker uncertainty, increases the cost of attacking the system, reduces the likelihood of an attacker locating a vulnerability, and reduces the exposure time of any located vulnerability. The MORE-MTD environment is effectuated by rotation of the operating systems at a given interval. The rotating operating systems create a consistently changing attack surface for remote attackers.

Operation of the Defense Acquisition System

DTIC Science & Technology

2008-12-08

United States Code (l) DoD Directive 8320.02, “Data Sharing in a Net-Centric Department of Defense,” December 2, 2004 (m) DoD Instruction 5200.39...2004 (t) ISO 15418-1999- “EAN/ UCC Application Identifiers and Fact Data Identifiers and Maintenance” (u) ISO 15434-1999 – “Transfer Syntax for High...Acquisition Knowledge Sharing System7 (y) Section 644 of title 15, United States Code, “Procurement strategies; contract bundling” (z) Public Law 101-576

Defense on the Move: Ant-Based Cyber Defense

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fink, Glenn A.; Haack, Jereme N.; McKinnon, Archibald D.

Many common cyber defenses (like firewalls and IDS) are as static as trench warfare allowing the attacker freedom to probe them at will. The concept of Moving Target Defense (MTD) adds dynamism to the defender side, but puts the systems to be defended themselves in motion, potentially at great cost to the defender. An alternative approach is a mobile resilient defense that removes attackers’ ability to rely on prior experience without requiring motion in the protected infrastructure itself. The defensive technology absorbs most of the cost of motion, is resilient to attack, and is unpredictable to attackers. The Ant-Based Cybermore » Defense (ABCD) is a mobile resilient defense providing a set of roaming, bio-inspired, digital-ant agents working with stationary agents in a hierarchy headed by a human supervisor. The ABCD approach provides a resilient, extensible, and flexible defense that can scale to large, multi-enterprise infrastructures like the smart electric grid.« less

77 FR 11367 - Defense Federal Acquisition Regulation Supplement; Extension of the Department of Defense Mentor...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-24

... DEPARTMENT OF DEFENSE Defense Acquisition Regulations System 48 CFR Part 219 and Appendix I to Chapter 2 RIN 0750-AH59 Defense Federal Acquisition Regulation Supplement; Extension of the Department of... Regulations System, Department of Defense (DoD). ACTION: Final rule. SUMMARY: DoD is issuing this final rule...

A two-dimensional neuropsychology of defense: fear/anxiety and defensive distance.

PubMed

McNaughton, Neil; Corr, Philip J

2004-05-01

We present in this paper a picture of the neural systems controlling defense that updates and simplifies Gray's "Neuropsychology of Anxiety". It is based on two behavioural dimensions: 'defensive distance' as defined by the Blanchards and 'defensive direction'. Defensive direction is a categorical dimension with avoidance of threat corresponding to fear and approach to threat corresponding to anxiety. These two psychological dimensions are mapped to underlying neural dimensions. Defensive distance is mapped to neural level, with the shortest defensive distances involving the lowest neural level (periaqueductal grey) and the largest defensive distances the highest neural level (prefrontal cortex). Defensive direction is mapped to separate parallel streams that run across these levels. A significant departure from prior models is the proposal that both fear and anxiety are represented at all levels. The theory is presented in a simplified form that does not incorporate the interactions that must occur between non-adjacent levels of the system. It also requires expansion to include the dimension of escapability of threat. Our current development and these proposed future extensions do not change the core concepts originally proposed by Gray and, we argue, demonstrate their enduring value.

An operational computer program to control Self Defense Surface Missile System operations

DOE Office of Scientific and Technical Information (OSTI.GOV)

Roe, C.L.

1991-12-01

An account is given of the system architecture and operational protocols of the NATO Seasparrow Surface Missile System (NSSMS) Operational Computer Program (OCP) which has been developed, and is being deployed multinationally, to respond against antiship missiles. Flowcharts are presented for the target detection and tracking, control, and engagement phases of the Self Defense Surface Missile System that is controlled by the OCP. USN and other NATO vessels will carry the NSSMS well into the next century; the OCP presently described will be deployed in the course of 1992 to enhance the self-defense capabilities of the NSSMS-equipped fleet. 8 refs.

75 FR 32639 - Defense Federal Acquisition Regulation Supplement; Limitations on Procurements With Non-Defense...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-08

... elements of the Department of Homeland Security concerned with the analysis of intelligence information... DEPARTMENT OF DEFENSE Defense Acquisition Regulations System 48 CFR Part 217 RIN 0750-AG67 Defense Federal Acquisition Regulation Supplement; Limitations on Procurements With Non-Defense Agencies (DFARS...

Department of Defense (DOD) Automated Biometric Identification System (ABIS) Version 1.2: Initial Operational Test and Evaluation Report

DTIC Science & Technology

2015-05-01

Director, Operational Test and Evaluation Department of Defense (DOD) Automated Biometric Identification System (ABIS) Version 1.2 Initial...Operational Test and Evaluation Report May 2015 This report on the Department of Defense (DOD) Automated Biometric Identification System...COVERED - 4. TITLE AND SUBTITLE Department of Defense (DOD) Automated Biometric Identification System (ABIS) Version 1.2 Initial Operational Test

Extending the Instructional Systems Development Methodology.

ERIC Educational Resources Information Center

O'Neill, Colin E.

1993-01-01

Describes ways that components of Information Engineering (IE) methodology can be used by training system developers to extend Instructional Systems Development (ISD) methodology. Aspects of IE that are useful in ISD are described, including requirements determination, group facilitation, integrated automated tool support, and prototyping.…

Use of the Homeland-Defense Operational Planning System (HOPS) for Emergency Management

DOE Office of Scientific and Technical Information (OSTI.GOV)

Durling, Jr., R L; Price, D E

2005-12-16

The Homeland-Defense Operational Planning System (HOPS), is a new operational planning tool leveraging Lawrence Livermore National Laboratory's expertise in weapons systems and in sparse information analysis to support the defense of the U.S. homeland. HOPS provides planners with a basis to make decisions to protect against acts of terrorism, focusing on the defense of facilities critical to U.S. infrastructure. Criticality of facilities, structures, and systems is evaluated on a composite matrix of specific projected casualty, economic, and sociopolitical impact bins. Based on these criteria, significant unidentified vulnerabilities are identified and secured. To provide insight into potential successes by malevolent actors,more » HOPS analysts strive to base their efforts mainly on unclassified open-source data. However, more cooperation is needed between HOPS analysts and facility representatives to provide an advantage to those whose task is to defend these facilities. Evaluated facilities include: refineries, major ports, nuclear power plants and other nuclear licensees, dams, government installations, convention centers, sports stadiums, tourist venues, and public and freight transportation systems. A generalized summary of analyses of U.S. infrastructure facilities will be presented.« less

Impact of Defense Industry Mergers on The Cost of Military Weapons Systems

DTIC Science & Technology

2007-12-01

over the last 16 years . This thesis reports the impact of these defense related mergers on the cost of military weapons systems. The Selected...the requirements for the degree of MASTER OF BUSINESS ADMINISTRATION from the NAVAL POSTGRADUATE SCHOOL December 2007 Author...Graduate School of Business and Public Policy iv THIS PAGE INTENTIONALLY LEFT BLANK v ABSTRACT The United States defense industry has been in a

Evaluation of the DEIMS (Defense Economic Impact Modeling System) System.

DTIC Science & Technology

1984-07-01

AOORESS(H d~fereet m Caii~dl Offiee) IS. SECURITY CLASS. (of Wd e~w Vr OUSDRE (DoD-IDA Management Office) UCASFE 1801 N. Beauregard Street UCASFE...Defense Spending Mr. Paul Dickens, PA&E Labor Demand - Dr. David Blond Conclusion - Dr. David L. Mdicol 11:00 Break SESSION III - IMPACT OF DEFENSE...presented highlights of the industrial and labor impact of defense spending during. . 1985-89. Mr. Paul Dickens then analysed trends in the I- .""L- " ’•L

Combat Identification Systems COMO Integrated Air Defense Model Evaluation (CISE) Study

DTIC Science & Technology

1989-02-01

use K or IR , whichever one applies) E-6 CAA-SR-89- 3 Subroutine PDECLR 1/21/88 Before label 1000 Insert: IF (IR.GT.10) IR a 10 These changes were made...Internal Distribution: Unclassified Library 2 F-2 CAA-SR-89- 3 GLOSSARY 1. ABBREVIATIONS, ACRONYMS, AND SHORT TERMS ADM2 Air Defense Models Modification...STUDY REPORT ’ , CAA-Sn-89- 3 i , .- CD o COMBAT IDENTIFICATION SYSTEMS N COMO INTEGRATED AIR DEFENSE MODEL EVALUATION (CISE) STUDY FEBRUARY 1989

Issues With Access to Acquisition Data and Information in the Department of Defense: Doing Data Right in Weapon System Acquisition

DTIC Science & Technology

2016-04-30

Defense: Doing Data Right in Weapon System Acquisition Nancy Moore, Senior Management Scientist, RAND Megan McKernan, Defense Research Analyst...Access to Acquisition Data & Information in the Department of Defense: Doing Data Right in Weapon System Acquisition Nancy Moore, Senior Management...With Access to Acquisition Data and Information in the Department of Defense: Doing Data Right in Weapon System Acquisition Nancy Y. Moore—is a

Defensive weapons and defense signals in plants: some metabolites serve both roles.

PubMed

Maag, Daniel; Erb, Matthias; Köllner, Tobias G; Gershenzon, Jonathan

2015-02-01

The defense of plants against herbivores and pathogens involves the participation of an enormous range of different metabolites, some of which act directly as defensive weapons against enemies (toxins or deterrents) and some of which act as components of the complex internal signaling network that insures that defense is timed to enemy attack. Recent work reveals a surprising trend: The same compounds may act as both weapons and signals of defense. For example, two groups of well-studied defensive weapons, glucosinolates and benzoxazinoids, trigger the accumulation of the protective polysaccharide callose as a barrier against aphids and pathogens. In the other direction, several hormones acting in defense signaling (and their precursors and products) exhibit activity as weapons against pathogens. Knowing which compounds are defensive weapons, which are defensive signals and which are both is vital for understanding the functioning of plant defense systems. © 2015 WILEY Periodicals, Inc.

Extended Warranty Management in the Department of Defense

DTIC Science & Technology

2012-10-01

of extended warranty contracts, as in Jack and Murthy (2007); Hartman and Laksana (2009); Li, Mallik , and Chhajed (2012); and Heese (2011), as well...product problems when the timing of warranty expiration varies. Journal of Business Research, 42(3), 265–270. Li, K., Mallik , S., & Chhajed, D

Acquisition Planning at the Defense Communications Agency.

DTIC Science & Technology

1984-04-01

guidelines for interaction are developed under the leadership of DCA agencywide integrators with the participation of personnel from DCA, the Services...Communications System DCSO - Defense Communications System Organizatin . DDN - Defense Data Network DEC - Decision Making DG - Defense Guidance DIA - Defense

A Locus Encoding Variable Defense Systems against Invading DNA Identified in Streptococcus suis

PubMed Central

Okura, Masatoshi; Nozawa, Takashi; Watanabe, Takayasu; Murase, Kazunori; Nakagawa, Ichiro; Takamatsu, Daisuke; Osaki, Makoto; Sekizaki, Tsutomu; Gottschalk, Marcelo; Hamada, Shigeyuki

2017-01-01

Streptococcus suis, an important zoonotic pathogen, is known to have an open pan-genome and to develop a competent state. In S. suis, limited genetic lineages are suggested to be associated with zoonosis. However, little is known about the evolution of diversified lineages and their respective phenotypic or ecological characteristics. In this study, we performed comparative genome analyses of S. suis, with a focus on the competence genes, mobile genetic elements, and genetic elements related to various defense systems against exogenous DNAs (defense elements) that are associated with gene gain/loss/exchange mediated by horizontal DNA movements and their restrictions. Our genome analyses revealed a conserved competence-inducing peptide type (pherotype) of the competence system and large-scale genome rearrangements in certain clusters based on the genome phylogeny of 58 S. suis strains. Moreover, the profiles of the defense elements were similar or identical to each other among the strains belonging to the same genomic clusters. Our findings suggest that these genetic characteristics of each cluster might exert specific effects on the phenotypic or ecological differences between the clusters. We also found certain loci that shift several types of defense elements in S. suis. Of note, one of these loci is a previously unrecognized variable region in bacteria, at which strains of distinct clusters code for different and various defense elements. This locus might represent a novel defense mechanism that has evolved through an arms race between bacteria and invading DNAs, mediated by mobile genetic elements and genetic competence. PMID:28379509

Extended Plate and Beam Wall System

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gunderson, Patti

Home Innovation Research Labs studied the extended plate and beam wall (EP&B) system during a two-year period from mid-2015 to mid-2017 to determine the wall’s structural performance, moisture durability, constructability, and costeffectiveness for use as a high-R enclosure system for energy code minimum and above-code performance in climate zones 4–8.

Extended length microchannels for high density high throughput electrophoresis systems

DOEpatents

Davidson, James C.; Balch, Joseph W.

2000-01-01

High throughput electrophoresis systems which provide extended well-to-read distances on smaller substrates, thus compacting the overall systems. The electrophoresis systems utilize a high density array of microchannels for electrophoresis analysis with extended read lengths. The microchannel geometry can be used individually or in conjunction to increase the effective length of a separation channel while minimally impacting the packing density of channels. One embodiment uses sinusoidal microchannels, while another embodiment uses plural microchannels interconnected by a via. The extended channel systems can be applied to virtually any type of channel confined chromatography.

The Gulf War's impact on ballistic missile defense systems

DOE Office of Scientific and Technical Information (OSTI.GOV)

Likourezos, G.

1993-01-01

During Desert Storm the United States and its allies had an overwhelming advantage over the Iraqi armed forces. Nonetheless, the Iraqis managed to strike Israel and Saudi Arabia with Scud missiles. Because of the changing political climate and the expanding transfer of technology among nations, there is great concern by the US Government about missile proliferation and the ability of any country to obtain weapons of mass destruction. The US Government tried to downplay this concern for many years until the recent events in the Middle East affirmed its seriousness. The truth is that every year countries once thought tomore » pose no international threat are acquiring biological, chemical, and nuclear weapons. Moreover, state-sponsored terrorist organizations could conceivably acquire these weapons in the future. In response to these concerns and in light of the lessons learned from the Gulf War, President George Bush in January 1991 redirected the SDI Program to concentrate on providing protection from limited ballistic missile strikes, rather than from an all-out nuclear missile attack by the Soviet Union. The Patriot air defense system, after knocking out Iraqi Scuds in the Gulf War with a near perfect record, appears for now to be the working model for the development of advanced ballistic missile defense systems - direct-kill missiles and projectiles instead of laser and particle beams. Even though the Patriot's use in Desert Storm has been argued by some to have been militarily insignificant, it has managed to change the viewpoint of many political and scientific leaders into believing that ballistic missile defense systems are needed to defend peaceful population centers and military installations from missile strikes like the ones on Israel and Saudi Arabia. 18 refs.« less

Passive automatic anti-piracy defense system of ships

NASA Astrophysics Data System (ADS)

Szustakowski, M.; Życzkowski, M.; Ciurapiński, W.; Karol, M.; Kastek, M.; Stachowiak, R.; Markowski, P.

2013-10-01

The article describes the technological solution for ship self-defense against pirate attacks. The paper presents the design solutions in the field of direct physical protection. All the solutions are connected with the latest optoelectronic and microwave systems and sensors to detect, recognize and the threat posed by pirates. In particular, tests of effectiveness and the detection-range of technology demonstrator developed by a team of authors were carried out.

Ballistic Missile Defense in the European Theater: Political, Military and Technical Considerations

DTIC Science & Technology

2007-04-15

currently valid OMB control number. PLEASE DO NOT RETURN YOUR FORM TO THE ABOVE ADDRESS. 1. REPORT DATE (DD-MM-YYYY) 15 04 2007 2. REPORT TYPE...the European Security Strategy. These strategic documents implicitly and explicitly build a strong case for bolstering missile defense capabilities...states. The NMS advocates the building of a defense in depth by extending defensive capabilities well beyond United States borders, and uses the

Defense Intelligence: Additional Steps Could Better Integrate Intelligence Input into DODs Acquisition of Major Weapon Systems

DTIC Science & Technology

2016-11-01

DEFENSE INTELLIGENCE Additional Steps Could Better Integrate Intelligence Input into DOD’s Acquisition of Major Weapon...States Government Accountability Office Highlights of GAO-17-10, a report to congressional committees November 2016 DEFENSE INTELLIGENCE ...Additional Steps Could Better Integrate Intelligence Input into DOD’s Acquisition of Major Weapon Systems What GAO Found The Department of Defense (DOD

Information Management Principles Applied to the Ballistic Missile Defense System

DTIC Science & Technology

2007-03-01

of a BMDS. From this, the Army produced the Nike -Zeus system comprised of four radars, the Zeus missile, and a computer fire control system (General...made the Nike -Zeus our first National Missile Defense (NMD) system named Sentinel. The architecture was to cover 14 locations, 10 of which were...1999). Additionally, there are cultural impacts (Gordon & Gordon, 1999). A company choosing an Apple OS may have to wage a big fight against the

The Jasmonate Pathway Is a Key Player in Systemically Induced Defense against Root Knot Nematodes in Rice1[C

PubMed Central

Nahar, Kamrun; Kyndt, Tina; De Vleesschauwer, David; Höfte, Monica; Gheysen, Godelieve

2011-01-01

Complex defense signaling pathways, controlled by different hormones, are involved in the reaction of plants to a wide range of biotic and abiotic stress factors. We studied the ability of salicylic acid, jasmonate (JA), and ethylene (ET) to induce systemic defense in rice (Oryza sativa) against the root knot nematode Meloidogyne graminicola. Exogenous ET (ethephon) and JA (methyl jasmonate) supply on the shoots induced a strong systemic defense response in the roots, exemplified by a major up-regulation of pathogenesis-related genes OsPR1a and OsPR1b, while the salicylic acid analog BTH (benzo-1,2,3-thiadiazole-7-carbothioic acid S-methyl ester) was a less potent systemic defense inducer from shoot to root. Experiments with JA biosynthesis mutants and ET-insensitive transgenics showed that ET-induced defense requires an intact JA pathway, while JA-induced defense was still functional when ET signaling was impaired. Pharmacological inhibition of JA and ET biosynthesis confirmed that JA biosynthesis is needed for ET-induced systemic defense, and quantitative real-time reverse transcription-polymerase chain reaction data revealed that ET application onto the shoots strongly activates JA biosynthesis and signaling genes in the roots. All data provided in this study point to the JA pathway to play a pivotal role in rice defense against root knot nematodes. The expression of defense-related genes was monitored in root galls caused by M. graminicola. Different analyzed defense genes were attenuated in root galls caused by the nematode at early time points after infection. However, when the exogenous defense inducers ethephon and methyl jasmonate were supplied to the plant, the nematode was less effective in counteracting root defense pathways, hence making the plant more resistant to nematode infection. PMID:21715672

48 CFR 225.7902 - Defense Trade Cooperation Treaties.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 48 Federal Acquisition Regulations System 3 2013-10-01 2013-10-01 false Defense Trade Cooperation Treaties. 225.7902 Section 225.7902 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE SOCIOECONOMIC PROGRAMS FOREIGN ACQUISITION EXPORT CONTROL 225.7902 Defense Trade Cooperation Treaties. This...

48 CFR 225.7902 - Defense Trade Cooperation Treaties.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 48 Federal Acquisition Regulations System 3 2014-10-01 2014-10-01 false Defense Trade Cooperation Treaties. 225.7902 Section 225.7902 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE SOCIOECONOMIC PROGRAMS FOREIGN ACQUISITION EXPORT CONTROL 225.7902 Defense Trade Cooperation Treaties. This...

A host defense role for a natural antiviral substance in the nervous system.

PubMed

Baron, S; Chopra, A K; Coppenhaver, D H; Gelman, B B; Poast, J; Singh, I P

1998-05-15

The pathogenesis of virus infections of the nervous system (NS) is regulated by host defenses. The defensive role of a major constitutive antiviral substance was studied by determining its distribution in the human nervous system, its concentration and the ability of this viral inhibitor to protect mice against viral infection. The 4000 kDa inhibitor complex in the human nervous system was detected in brain gray and white matter, spinal cord, and sciatic nerve but not in human cerebrospinal fluid. The inhibitor was found in the extracellular medium incubated with minced murine brain. The inhibitory titer ranged from approximately 50 to 200 antiviral units per gram against polio 1, Semliki Forest, Banzi, mengo, Newcastle disease and herpes simplex 1 viruses. The inhibitor is composed of lipid and essential protein and carbohydrate moieties as determined by enzymatic inactivation. Protection of inhibitor-treated mice was demonstrated against both an alphavirus and a picornavirus. Thus a natural defensive role for the broadly antiviral inhibitor is suggested by its constitutively high concentration, wide distribution in nervous system tissues, presence in extracellular fluid and its ability to provide protection in infected mice.

Density-dependent adjustment of inducible defenses.

PubMed

Tollrian, Ralph; Duggen, Sonja; Weiss, Linda C; Laforsch, Christian; Kopp, Michael

2015-08-03

Predation is a major factor driving evolution, and organisms have evolved adaptations increasing their survival chances. However, most defenses incur trade-offs between benefits and costs. Many organisms save costs by employing inducible defenses as responses to fluctuating predation risk. The level of defense often increases with predator densities. However, individual predation risk should not only depend on predator density but also on the density of conspecifics. If the predator has a saturating functional response one would predict a negative correlation between prey density and individual predation risk and hence defense expression. Here, we tested this hypothesis using six model systems, covering a taxonomic range from protozoa to rotifers and crustaceans. In all six systems, we found that the level of defense expression increased with predator density but decreased with prey density. In one of our systems, i.e. in Daphnia, we further show that the response to prey density is triggered by a chemical cue released by conspecifics and congeners. Our results indicate that organisms adjust the degree of defense to the acute predation risk, rather than merely to predators' densities. Our study suggests that density-dependent defense expression reflects accurate predation-risk assessment and is a general principle in many inducible-defense systems.

Density-dependent adjustment of inducible defenses

PubMed Central

Tollrian, Ralph; Duggen, Sonja; Weiss, Linda C.; Laforsch, Christian; Kopp, Michael

2015-01-01

Predation is a major factor driving evolution, and organisms have evolved adaptations increasing their survival chances. However, most defenses incur trade-offs between benefits and costs. Many organisms save costs by employing inducible defenses as responses to fluctuating predation risk. The level of defense often increases with predator densities. However, individual predation risk should not only depend on predator density but also on the density of conspecifics. If the predator has a saturating functional response one would predict a negative correlation between prey density and individual predation risk and hence defense expression. Here, we tested this hypothesis using six model systems, covering a taxonomic range from protozoa to rotifers and crustaceans. In all six systems, we found that the level of defense expression increased with predator density but decreased with prey density. In one of our systems, i.e. in Daphnia, we further show that the response to prey density is triggered by a chemical cue released by conspecifics and congeners. Our results indicate that organisms adjust the degree of defense to the acute predation risk, rather than merely to predators’ densities. Our study suggests that density-dependent defense expression reflects accurate predation-risk assessment and is a general principle in many inducible-defense systems. PMID:26235428

Extended GTST-MLD for aerospace system safety analysis.

PubMed

Guo, Chiming; Gong, Shiyu; Tan, Lin; Guo, Bo

2012-06-01

The hazards caused by complex interactions in the aerospace system have become a problem that urgently needs to be settled. This article introduces a method for aerospace system hazard interaction identification based on extended GTST-MLD (goal tree-success tree-master logic diagram) during the design stage. GTST-MLD is a functional modeling framework with a simple architecture. Ontology is used to extend the ability of system interaction description in GTST-MLD by adding the system design knowledge and the past accident experience. From the level of functionality and equipment, respectively, this approach can help the technician detect potential hazard interactions. Finally, a case is used to show the method. © 2011 Society for Risk Analysis.

Role of resveratrol in regulation of cellular defense systems against oxidative stress.

PubMed

Truong, Van-Long; Jun, Mira; Jeong, Woo-Sik

2018-01-01

Resveratrol, a natural polyphenolic compound, is found in various kinds of fruits, plants, and their commercial products such as red wine. It has been demonstrated to exhibit a variety of health-promoting effects including prevention and/or treatment of cardiovascular diseases, inflammation, diabetes, neurodegeneration, aging, and cancer. Cellular defensive properties of resveratrol can be explained through its ability of either directly neutralizing reactive oxygen species/reactive nitrogen species (ROS/RNS) or indirectly upregulating the expression of cellular defensive genes. As a direct antioxidant agent, resveratrol scavenges diverse ROS/RNS as well as secondary organic radicals with mechanisms of hydrogen atom transfer and sequential proton loss electron transfer, thereby protecting cellular biomolecules from oxidative damage. Resveratrol also enhances the expression of various antioxidant defensive enzymes such as heme oxygenase 1, catalase, glutathione peroxidase, and superoxide dismutase as well as the induction of glutathione level responsible for maintaining the cellular redox balance. Such defenses could be achieved by regulating various signaling pathways including sirtuin 1, nuclear factor-erythroid 2-related factor 2 and nuclear factor κB. This review provides current understanding and information on the role of resveratrol in cellular defense system against oxidative stress. © 2017 BioFactors, 44(1):36-49, 2018. © 2017 International Union of Biochemistry and Molecular Biology.

Bayesian performance metrics and small system integration in recent homeland security and defense applications

NASA Astrophysics Data System (ADS)

Jannson, Tomasz; Kostrzewski, Andrew; Patton, Edward; Pradhan, Ranjit; Shih, Min-Yi; Walter, Kevin; Savant, Gajendra; Shie, Rick; Forrester, Thomas

2010-04-01

In this paper, Bayesian inference is applied to performance metrics definition of the important class of recent Homeland Security and defense systems called binary sensors, including both (internal) system performance and (external) CONOPS. The medical analogy is used to define the PPV (Positive Predictive Value), the basic Bayesian metrics parameter of the binary sensors. Also, Small System Integration (SSI) is discussed in the context of recent Homeland Security and defense applications, emphasizing a highly multi-technological approach, within the broad range of clusters ("nexus") of electronics, optics, X-ray physics, γ-ray physics, and other disciplines.

Exploring extended scope of practice in dietetics: A systems approach.

PubMed

Ryan, Dominique; Pelly, Fiona; Purcell, Elizabeth

2017-09-01

The aim of this study was to explore health professionals' perceptions of an extended scope of a practice clinic, and develop a framework using a systems approach to facilitate extended scope models across various health settings. A qualitative investigation using semi-structured interviews with four health professionals involved in an extended scope dietitian-led gastroenterology clinic in a hospital in regional Queensland was conducted. A case study design was utilised to investigate interviewees' perceptions of the clinic. Participants were conveniently, purposively sampled. Transcript analysis involved a descriptive analytical approach. Interviewee responses were coded and categorised into themes, and investigator triangulation was used to ensure consistency between individual analyses. A secondary interpretative analysis was conducted where relationships between key themes were mapped to the Systems Engineering Initiative for Patient Safety work system model. Interviewees identified various factors as vital inputs to the work system. These were categorised into the four key elements: stakeholder support, resources, planning and the dietitian. Clinic outcomes were categorised into the impact on four key groups: patients, the dietitian, the multidisciplinary team and the health system. Mapping of the relationships between inputs and outcomes resulted in an implementation framework for extended scope of practice. Extended scope of practice in dietetics may provide positive outcomes for various stakeholders. However, further development of extended scope roles for dietitians requires increased advocacy and support from governments, professional bodies, training institutions and dietitians. We have developed an implementation framework which can be utilised by health professionals interested in embracing an extended scope model of care. © 2016 Dietitians Association of Australia.

Codifying Information Assurance Controls for Department of Defense (DoD) Supervisory Control and Data Acquisition (SCADA) Systems

DTIC Science & Technology

2010-03-01

CODIFYING INFORMATION ASSURANCE CONTROLS FOR DEPARTMENT OF DEFENSE (DOD) SUPERVISORY CONTROL AND DATA...Force, Department of Defense, or the U.S. Government. AFIT/GCO/ENG/10-13 CODIFYING INFORMATION ASSURANCE CONTROLS FOR DEPARTMENT OF...DEFENSE (DOD) SUPERVISORY CONTROL AND DATA ACQUISITION (SCADA) SYSTEMS THESIS Presented to the Faculty Department of Electrical and Computer

2015 Assessment of the Ballistic Missile Defense System (BMDS)

DTIC Science & Technology

2016-04-01

performance and test adequacy of the BMDS, its four autonomous BMDS systems, and its sensor/command and control architecture. The four autonomous BMDS...Patriot. The Command and Control , Battle Management, and Communications (C2BMC) element anchors the sensor/command and control architecture. This...Warfare operations against a cruise missile surrogate. Ground-based Midcourse Defense (GMD). GMD has demonstrated capability against small

Extended mission life support systems

NASA Technical Reports Server (NTRS)

Quattrone, P. D.

1985-01-01

Extended manned space missions which include interplanetary missions require regenerative life support systems. Manned mission life support considerations are placed in perspective and previous manned space life support system technology, activities and accomplishments in current supporting research and technology (SR&T) programs are reviewed. The life support subsystem/system technologies required for an enhanced duration orbiter (EDO) and a space operations center (SOC), regenerative life support functions and technology required for manned interplanetary flight vehicles, and future development requirements are outlined. The Space Shuttle Orbiters (space transportation system) is space cabin atmosphere is maintained at Earth ambient pressure of 14.7 psia (20% O2 and 80% N2). The early Shuttle flights will be seven-day flights, and the life support system flight hardware will still utilize expendables.

The Impact of Environmental Regulation on Defense System Acquisition Management

DTIC Science & Technology

1976-05-01

producer, had been the sole source for the fuel. The process of manufacturing the fuel also produced a toxic ~arcinogenic byproduct. This condition caused...minimized. Could the design be quieter? Does the maintenance of the system require environmentally sensitive equipment, processes , or material? For ... Of particular interest to this report is the effect of such regulation on the defense system acquisition process . There is a direct impact on the

Multi-Objective Optimization of System Capability Satisficing in Defense Acquisition

DTIC Science & Technology

2012-01-01

of System Capability Satisficing in Defense Acquisition 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d...PROJECT NUMBER 5e. TASK NUMBER 5f. WORK UNIT NUMBER 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) Stevens Institute of Technology,School of Systems...Report (SAR) 18. NUMBER OF PAGES 27 19a. NAME OF RESPONSIBLE PERSON a. REPORT unclassified b. ABSTRACT

77 FR 11355 - Defense Federal Acquisition Regulation Supplement; Business Systems-Definition and Administration...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-24

... the interim rule. Contractor business systems and internal controls are the first line of defense... contractor's accounting system shall provide for management reviews or internal audits of the contractor's... controls as part of any evaluation as to the reliability of information produced by a business system(s...

75 FR 32416 - Defense Science Board

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-08

... DEPARTMENT OF DEFENSE Office of the Secretary Defense Science Board AGENCY: Department of Defense (DoD). ACTION: Notice of advisory committee meeting. SUMMARY: The Defense Science Board Task Force on the Survivability of DoD Systems and Assets to Electromagnetic Pulse (EMP) and other Nuclear Weapons...

Selenium delays tomato fruit ripening by inhibiting ethylene biosynthesis and enhancing the antioxidant defense system.

PubMed

Zhu, Zhu; Chen, Yanli; Shi, Guoqing; Zhang, Xueji

2017-03-15

The antioxidant activity of selenium (Se) detoxifies reactive oxygen species (ROS) in plants and animals. In the present study, we elucidated the mechanism underlying Se induced fruit development and ripening. Our study showed that foliar pretreatment with 1mgL -1 sodium selenate effectively delayed fruit ripening and maintained fruit quality. Gene expression studies revealed that the repression of ethylene biosynthetic genes 1-aminocyclopropane-1-carboxylic acid (ACC) synthase and ACC oxidase decreased ethylene production and respiration rate. Moreover, Se treatment probably boosted the antioxidant defense system to reduce ROS generation and membrane damage. The enhanced antioxidative effect was attributed to higher glutathione content and increased activity of enzymes such as glutathione peroxidase and glutathione reductase. The upregulation of respiratory burst oxidase homologue genes in tomato fruit may also contribute to the enhanced antioxidative effect. Selenium treatment represents a promising strategy for delaying ripening and extending the shelf life of tomato fruit. Copyright © 2016 Elsevier Ltd. All rights reserved.

Report on Defense Business Operations to the Congressional Defense Committees

DTIC Science & Technology

2009-03-15

7 . PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) Department of Defense,Business Information Agency,Washington,DC 8. PERFORMING ORGANIZATION...Defense Business Transformation 7 Table 2-2: System Modernizations and Initiatives by Business Enterprise Priority* Personnel Visibility...and people to ensure reliable and accurate delivery of acceptable goods and services. The procurement functional area establishes requirements for

Silverleaf whitefly induces salicylic acid defenses and suppresses effectual jasmonic acid defenses.

PubMed

Zarate, Sonia I; Kempema, Louisa A; Walling, Linda L

2007-02-01

The basal defenses important in curtailing the development of the phloem-feeding silverleaf whitefly (Bemisia tabaci type B; SLWF) on Arabidopsis (Arabidopsis thaliana) were investigated. Sentinel defense gene RNAs were monitored in SLWF-infested and control plants. Salicylic acid (SA)-responsive gene transcripts accumulated locally (PR1, BGL2, PR5, SID2, EDS5, PAD4) and systemically (PR1, BGL2, PR5) during SLWF nymph feeding. In contrast, jasmonic acid (JA)- and ethylene-dependent RNAs (PDF1.2, VSP1, HEL, THI2.1, FAD3, ERS1, ERF1) were repressed or not modulated in SLWF-infested leaves. To test for a role of SA and JA pathways in basal defense, SLWF development on mutant and transgenic lines that constitutively activate or impair defense pathways was determined. By monitoring the percentage of SLWF nymphs in each instar, we show that mutants that activate SA defenses (cim10) or impair JA defenses (coi1) accelerated SLWF nymphal development. Reciprocally, mutants that activate JA defenses (cev1) or impair SA defenses (npr1, NahG) slowed SLWF nymphal development. Furthermore, when npr1 plants, which do not activate downstream SA defenses, were treated with methyl jasmonate, a dramatic delay in nymph development was observed. Collectively, these results showed that SLWF-repressed, JA-regulated defenses were associated with basal defense to the SLWF.

Evolution of RNA- and DNA-guided antivirus defense systems in prokaryotes and eukaryotes: common ancestry vs convergence.

PubMed

Koonin, Eugene V

2017-02-10

Complementarity between nucleic acid molecules is central to biological information transfer processes. Apart from the basal processes of replication, transcription and translation, complementarity is also employed by multiple defense and regulatory systems. All cellular life forms possess defense systems against viruses and mobile genetic elements, and in most of them some of the defense mechanisms involve small guide RNAs or DNAs that recognize parasite genomes and trigger their inactivation. The nucleic acid-guided defense systems include prokaryotic Argonaute (pAgo)-centered innate immunity and CRISPR-Cas adaptive immunity as well as diverse branches of RNA interference (RNAi) in eukaryotes. The archaeal pAgo machinery is the direct ancestor of eukaryotic RNAi that, however, acquired additional components, such as Dicer, and enormously diversified through multiple duplications. In contrast, eukaryotes lack any heritage of the CRISPR-Cas systems, conceivably, due to the cellular toxicity of some Cas proteins that would get activated as a result of operon disruption in eukaryotes. The adaptive immunity function in eukaryotes is taken over partly by the PIWI RNA branch of RNAi and partly by protein-based immunity. In this review, I briefly discuss the interplay between homology and analogy in the evolution of RNA- and DNA-guided immunity, and attempt to formulate some general evolutionary principles for this ancient class of defense systems. This article was reviewed by Mikhail Gelfand and Bojan Zagrovic.

76 FR 28855 - Defense Federal Acquisition Regulation Supplement; Business Systems-Definition and Administration

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-18

... business systems and internal controls are the first line of defense against waste, fraud, and abuse. Weak control systems increase the risk of unallowable and unreasonable costs on Government contracts. To...'s accounting system rather than the adequacy of the contractor's control environment and overall...

Interoperability In Multi-Layered Active Defense:The Need For Commonality And Robustness Between Active Defense Weapon Systems

DTIC Science & Technology

2016-02-16

into areas where there is no access to maritime platforms. Sea-based interceptor platforms have the ability to intercept targets at each stage of the...argues that the most efficient concept for integrating active defense weapon systems is a multi- layered architecture with redundant intercept ...faster data transfer and will prevent data loss. The need for almost 100% interception successes is increasing as the threat becomes more

Department of Defense Systems Engineering FY 2012 Annual Report

DTIC Science & Technology

2013-03-01

by the Utility Helicopter PMO, is utilizing the latest Defense Acquisition Guidelines and previously approved PEO AVN SEP examples to develop all...efforts. As a whole, all of PEO AVN Program Management Offices understand the importance of systems engineering. They stress the continued use of...established SE guidelines, practices and procedures throughout our acquisition processes. PEO AVN , working with the AMRDEC SE Division, has

78 FR 41331 - Defense Federal Acquisition Regulation Supplement; Technical Amendments

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-10

... DEPARTMENT OF DEFENSE Defense Acquisition Regulations System 48 CFR Part 225 Defense Federal Acquisition Regulation Supplement; Technical Amendments AGENCY: Defense Acquisition Regulations System, Department of Defense (DoD). ACTION: Final rule. SUMMARY: DoD is making technical amendment to the Defense...

Uncertainties in building a strategic defense.

PubMed

Zraket, C A

1987-03-27

Building a strategic defense against nuclear ballistic missiles involves complex and uncertain functional, spatial, and temporal relations. Such a defensive system would evolve and grow over decades. It is too complex, dynamic, and interactive to be fully understood initially by design, analysis, and experiments. Uncertainties exist in the formulation of requirements and in the research and design of a defense architecture that can be implemented incrementally and be fully tested to operate reliably. The analysis and measurement of system survivability, performance, and cost-effectiveness are critical to this process. Similar complexities exist for an adversary's system that would suppress or use countermeasures against a missile defense. Problems and opportunities posed by these relations are described, with emphasis on the unique characteristics and vulnerabilities of space-based systems.

Impact of Contract Bundling and Consolidation on Defense Acquisition System and Defense Industrial Base: The Case of the U.S. Department of the Navy

DTIC Science & Technology

2012-04-27

Department of the Navy 27 April 2012 by Max V. Kidalov, J.D., LL.M., Assistant Professor Graduate School of Business & Public Policy Naval...Consolidation on Defense Acquisition System and Defense Industrial Base: The Case of the U.S. Department of the Navy 5a. CONTRACT NUMBER 5b. GRANT...examining Department of the Navy (DoN) bundled and consolidated contracts for fiscal year (FY) 2010, the record year for bundling and consolidation in

75 FR 76692 - Defense Federal Acquisition Regulation Supplement; Business Systems-Definition and Administration...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-09

..., and 252 RIN 0750-AG58 Defense Federal Acquisition Regulation Supplement; Business Systems--Definition... for Business Systems--Definition and Administration (DFARS Case 2009-D038) in the Federal Register on... improve the effectiveness of DoD oversight of contractor business systems. The comment period is being...

75 FR 2457 - Defense Federal Acquisition Regulation Supplement; Business Systems-Definition and Administration...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-15

... INFORMATION: A. Background Contractor business systems and internal controls are the first line of defense against waste, fraud, and abuse. Weak control systems increase the risk of unallowable and unreasonable... Office of Management and Budget (OMB) as follows: (1) Accounting Systems--OMB Clearance 9000-0011; (2...

Control Systems Cyber Security:Defense in Depth Strategies

DOE Office of Scientific and Technical Information (OSTI.GOV)

David Kuipers; Mark Fabro

2006-05-01

Information infrastructures across many public and private domains share several common attributes regarding IT deployments and data communications. This is particularly true in the control systems domain. A majority of the systems use robust architectures to enhance business and reduce costs by increasing the integration of external, business, and control system networks. However, multi-network integration strategies often lead to vulnerabilities that greatly reduce the security of an organization, and can expose mission-critical control systems to cyber threats. This document provides guidance and direction for developing ‘defense-in-depth’ strategies for organizations that use control system networks while maintaining a multi-tier information architecturemore » that requires: Maintenance of various field devices, telemetry collection, and/or industrial-level process systems Access to facilities via remote data link or modem Public facing services for customer or corporate operations A robust business environment that requires connections among the control system domain, the external Internet, and other peer organizations.« less

Control Systems Cyber Security: Defense-in-Depth Strategies

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mark Fabro

2007-10-01

Information infrastructures across many public and private domains share several common attributes regarding IT deployments and data communications. This is particularly true in the control systems domain. A majority of the systems use robust architectures to enhance business and reduce costs by increasing the integration of external, business, and control system networks. However, multi-network integration strategies often lead to vulnerabilities that greatly reduce the security of an organization, and can expose mission-critical control systems to cyber threats. This document provides guidance and direction for developing ‘defense-in-depth’ strategies for organizations that use control system networks while maintaining a multi-tier information architecturemore » that requires: • Maintenance of various field devices, telemetry collection, and/or industrial-level process systems • Access to facilities via remote data link or modem • Public facing services for customer or corporate operations • A robust business environment that requires connections among the control system domain, the external Internet, and other peer organizations.« less

Strategic Missile Defense & Nuclear Deterrence

NASA Astrophysics Data System (ADS)

Grego, Laura

The United States has pursued defenses against nuclear-armed long-range ballistic missiles since at least the 1950s. At the same time, concerns that missile defenses could undermine nuclear deterrence and potentially spark an arms race led the United States and Soviet Union to negotiate limits on these systems. The 1972 Anti-Ballistic Missile Treaty constrained strategic missile defenses for thirty years. After abandoning the treaty in 2002, President George W. Bush began fielding the Ground-based Midcourse Defense (GMD) homeland missile defense system on an extremely aggressive schedule, nominally to respond to threats from North Korea and Iran. Today, nearly fifteen years after its initial deployment, the potential and the limits of this homeland missile defense are apparent. Its test record is poor and it has no demonstrated ability to stop an incoming missile under real-world conditions. No credible strategy is in place to solve the issue of discriminating countermeasures. Insufficient oversight has not only exacerbated the GMD system's problems, but has obscured their full extent, which could encourage politicians and military leaders to make decisions that actually increase the risk of a missile attack against the United States. These are not the only costs. Both Russia and China have repeatedly expressed concerns that U.S. missile defenses adversely affect their own strategic capabilities and interests, particularly taken in light of the substantial US nuclear forces. This in turn affects these countries' nuclear modernization priorities. This talk will provide a technical overview of the US strategic missile defense system, and how it relates to deterrence against non-peer adversaries as well as how it affects deterrence with Russia and China and the long-term prospects for nuclear reductions

Analysis of System Training Impact for Major Defense Acquisition Programs (MDAPs): Training Systems Acquisition

DTIC Science & Technology

2012-07-01

Background The Patriot system began because of the need to replace an aging and limited air defense system in the 1970s, the Nike -Hercules, and...1980s by Bolt, Beranek & Newman Inc . that overlaid student performance and expert solutions in a real-time simulation, with feedback from an...Interaction and Interface Design Team at Aptima, Inc . In this role she managed and led the work-centered development of a variety of military and

Program Manager: The Journal of the Defense Systems Management College. Volume 15, Number 4, July-August 1986.

DTIC Science & Technology

1986-08-01

Architect, troi systems, CAD CAM, and com- functional analysis , synthesis, and National Bureau of Standards, mon engineering data bases will be the trade...Recurrent analysis of a management these s h e m evolutionary chain of data processing problem combining real data and ponents of defense support system...at the Defense first constructed his support simulator Systems Management College, the by assembling appropriate analysis Data Storage and Retrieval

Changes in the glucosinolate-myrosinase defense system in Brassica juncea cotyledons during seedling development.

PubMed

Wallace, S K; Eigenbrode, Sanford D

2002-02-01

Optimal defense theory (ODT) predicts that plant defenses will be allocated to plant organs and tissues in proportion to their relative fitness values and susceptibilities to attack. This study was designed to test ODT predictions on the myrosinase-glucosinolate defense system in Brassica juncea by examining the relationships between the fitness value of B. juncea cotyledons and the levels and effectiveness of cotyledon defenses. Specifically, we estimated fitness value of cotyledons during plant development by measuring plant growth and seed production after cotyledon damage or removal at successive seedling ages. Cotyledon removal within five days of emergence had a significant impact on growth and seed production, but cotyledon removal at later stages did not. Consistent with ODT, glucosinolate and myrosinase levels in cotyledons also declined with seedling age, as did relative defenses against a generalist herbivore, Spodoptera eridania, as estimated by bioassay. Declines in glucosinolates were as predicted by a passive, allometric dilution model based on cotyledon expansion. Declines in myrosinase activity were significantly more gradual than predicted by allometric dilution, suggesting active retention of myrosinase activity as young cotyledons expand.

Defensive platform size and survivability. [Platform survivability

DOE Office of Scientific and Technical Information (OSTI.GOV)

Canavan, Gregory H.

1988-06-01

This report discusses the survivability of space platforms, concentrating on space based kinetic energy interceptors. It evaluates the efficacy of hardening, maneuver, self-defense, and deception in extending the survivability of platforms of varying sizes to expected threats, concluding that they should be adequate in the near and mid terms.

Silymarin Ameliorates Oxidative Stress and Enhances Antioxidant Defense System Capacity in Cadmium-Treated Mice.

PubMed

Farjad, Elham; Momeni, Hamid Reza

2018-10-01

Cadmium is an environmental pollutant which induces oxidative stress while silymarin as an antioxidant is able to scavenge free radicals. The aim of the present study was to investigate the effect of silymarin on oxidative stress markers and antioxidant defense system capacity in mice treated with cadmium chloride. In this experimental study, adult mice were divided into four groups as follow: i. Control, ii. Cadmium chloride (5 mg/kg b.w., s.c.), iii. Silymarin+cadmium chloride, and iv. Silymarin (100 mg/kg b.w., i.p.). Mice were treated with cadmium chloride for 24 hours and silymarin was administered 24 hours before the cadmium. Blood samples were then collected from the experimental groups and their sera were prepared. To investigate oxidative stress markers in the serum, the amount of malondialdehyde (MDA) and thiol groups (-SH) were evaluated. To measure the total antioxidant power in the serum, Ferric Reducing/ Antioxidant Power (FRAP) method was used. In addition, the activity of enzymes including catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GPx) was assessed to evaluate serum antioxidant defense power. In the cadmium-treated group, the amount of MDA significantly increased as compared to the control group. In silymarin+cadmium group, silymarin significantly ameliorated the level of MDA compared to the cadmium group. In addition, cadmium significantly reduced serum FRAP, the activity of antioxidant defense system enzymes and thiol groups compared to the control. In silymarin+cadmium group, silymarin could significantly reverse the reduction of these markers compared to the cadmium group. Administration of silymarin alone caused a significant increase in serum FRAP, the activity of antioxidant defense system enzymes and thiol groups compared to the control group. Silymarin as a powerful antioxidant reverses the toxic effect of cadmium on the serum levels of lipid peroxidation, total antioxidant power, antioxidant defense system

An Exploratory Analysis of the U.S. System of Major Defense Acquisition Utilizing the CLIOS Process

DTIC Science & Technology

2009-09-01

SPENDING COUNTRIES .............................................20 1. The United States’ Defense Acquisition System..............................21 2...Improvement Initiatives ...............................................................20 Table 4. The Top 15 Military Spender Countries in 2008...other top military spending countries . It will end with a review of the major defense acquisition literature. This literature review will focus on

78 FR 13543 - Defense Federal Acquisition Regulation Supplement; Technical Amendments

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-28

... DEPARTMENT OF DEFENSE Defense Acquisition Regulations System 48 CFR Parts 201, 204, 215, 225, 227, 242, 245, and 252 Defense Federal Acquisition Regulation Supplement; Technical Amendments AGENCY: Defense Acquisition Regulations System, Department of Defense (DoD). ACTION: Final rule. SUMMARY: DoD is...

78 FR 12294 - Proposed Information Collection; Comment Request; Defense Priorities and Allocations System

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-22

... Request; Defense Priorities and Allocations System AGENCY: Bureau of Industry and Security, Commerce...: Direct all written comments to Jennifer Jessup, Departmental Paperwork Clearance Officer, Department of... Priorities and Allocations System regulation (15 CFR part 700) must retain the records for at least 3 years...

75 FR 12173 - Proposed Information Collection; Comment Request; Defense Priorities and Allocations System

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-15

... Allocations System regulation (15 CFR part 700) must retain the records for at least 3 years. II. Method of... Request; Defense Priorities and Allocations System AGENCY: Bureau of Industry and Security, Commerce...: Direct all written comments to Diana Hynek, Departmental Paperwork Clearance Officer, Department of...

Restricted emigration, system inescapability, and defense of the status quo: system-justifying consequences of restricted exit opportunities.

PubMed

Laurin, Kristin; Shepherd, Steven; Kay, Aaron C

2010-08-01

The freedom to emigrate at will from a geographic location is an internationally recognized human right. However, this right is systematically violated by restrictive migration policies. In three experiments, we explored the psychological consequences of violating the right to mobility. Our results suggest that, ironically, restricted freedom of movement can lead to increased system justification (i.e., increased support of the status quo). In Study 1, we found that participants who read that their country was difficult to leave became stronger defenders of their system's legitimacy than before, even in domains unrelated to emigration policy (e.g., gender relations). In Study 2, we demonstrated that this increased system defense was the result of a motivated process. In Study 3, we broadened the scope of this psychological phenomenon by conceptually replicating it using a different system (participants' university) and measure of system defense. The importance of these two findings-the first experimental demonstration of the psychological consequences of restrictive emigration policies and the introduction of a novel psychological phenomenon-is discussed.

Application of System and Integration Readiness Levels to Department of Defense Research and Development

DTIC Science & Technology

2016-07-01

etc., and all of the IRL1n rather than a technology-centric approach that included TR L1 with all its interfaces. The inter- face -centric approach...Acquisition Research Journal , 23(3), In Print. The average of the SRL vector, equation (4), describes how mature the sys- tem is. The Sauser approach...Application of System and Integration Readiness Levels to Department of Defense Research and Development. Defense Acquisition Research Journal , 23(3), In

Artificial Diversity and Defense Security (ADDSec) Final Report.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chavez, Adrian R.; Hamlet, Jason; Stout, William M.S.

Critical infrastructure systems continue to foster predictable communication patterns and static configurations over extended periods of time. The static nature of these systems eases the process of gathering reconnaissance information that can be used to design, develop, and launch attacks by adversaries. In this research effort, the early phases of an attack vector will be disrupted by randomizing application port numbers, IP addresses, and communication paths dynamically through the use of overlay networks within Industrial Control Systems (ICS). These protective measures convert static systems into "moving targets," adding an additional layer of defense. Additionally, we have developed a framework thatmore » automatically detects and defends against threats within these systems using an ensemble of machine learning algorithms that classify and categorize abnormal behavior. Our proof-of-concept has been demonstrated within a representative ICS environment. Performance metrics of our proof-of-concept have been captured with latency impacts of less than a millisecond, on average.« less

System Requirements Analysis and Technological Support for the Ballistic Missile Defense System (BMDS) - FY07 Progress Report

DTIC Science & Technology

2007-07-01

Systems , Boeing-led Airborne Laser Team Actively Tracks Airborne Target, Compensates for Atmospheric Turbulence and Fires Sur- rogate High-Energy Laser...7100 System Requirements Analysis and Technological Support for the Ballistic Missile Defense System (BMDS) FY07 Progress Report By...Office of Management and Budget , Paperwork Reduction Project (0704-0188) Washington DC 20503. 1. AGENCY USE ONLY (Leave blank) 2. REPORT DATE July

Defense Planning in the Ministry of Defense of Ukraine: Decade of Attempts and Mistakes

DTIC Science & Technology

2015-06-01

Defense. (University of California Press, Berkeley and Los Angeles , 1967). 22 but due to the Soviet Union basis system, it is not as efficient in...Making for Defense. University of California Press, Berkeley and Los Angeles , 1967. Hitch, Charles Johnston and Roland N. McKean. The Economics of...loss of defense is not an instantaneous phenomenon. This phenomenon has led to human disorder, blind and continuous personnel downsizing, reform of the

Extended attention span training system

NASA Technical Reports Server (NTRS)

Pope, Alan T.; Bogart, Edward H.

1991-01-01

Attention Deficit Disorder (ADD) is a behavioral disorder characterized by the inability to sustain attention long enough to perform activities such as schoolwork or organized play. Treatments for this disorder include medication and brainwave biofeedback training. Brainwave biofeedback training systems feed back information to the trainee showing him how well he is producing the brainwave pattern that indicates attention. The Extended Attention Span Training (EAST) system takes the concept a step further by making a video game more difficult as the player's brainwaves indicate that attention is waning. The trainee can succeed at the game only by maintaining an adequate level of attention. The EAST system is a modification of a biocybernetic system that is currently being used to assess the extent to which automated flight management systems maintain pilot engagement. This biocybernetic system is a product of a program aimed at developing methods to evaluate automated flight deck designs for compatibility with human capabilities. The EAST technology can make a contribution in the fields of medical neuropsychology and neurology, where the emphasis is on cautious, conservative treatment of youngsters with attention disorders.

Defense.gov Special Report: Defense Intelligence

Science.gov Websites

Department of Defense Submit Search Defense intelligence is critical to the Defense Department's role in and conduct successful military and security operations that protect America. Defense Intelligence News Story Intelligence Chief Describes 'Pervasive Uncertainty' of Worldwide Threats "

76 FR 27274 - Defense Federal Acquisition Regulation Supplement; Technical Amendments

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-11

... DEPARTMENT OF DEFENSE Defense Acquisition Regulations System 48 CFR Part 225 Defense Federal Acquisition Regulation Supplement; Technical Amendments AGENCY: Defense Acquisition Regulations System... Federal Acquisition Regulation Supplement (DFARS) to direct contracting officers to additional guidance on...

Defense Acquisitions. Missile Defense Agency Fields Initial Capability but Falls Short of Original Goals

DTIC Science & Technology

2006-03-01

Implementation Plan MAP Missile Defense System Assurance Provisions MDA Missile Defense System NASA National Aeronautics and Space Administration NFIRE ...fourth element, KEI, also delayed some activities related to its Near Field Infrared Experiment ( NFIRE ), which is being conducted to gather data on the...to complete a number of tasks that would have enabled it to conduct the NFIRE experiment. The experiment places sensors aboard a satellite that

78 FR 67133 - Information Collection Requirement; Defense Federal Acquisition Regulation Supplement...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-11-08

... DEPARTMENT OF DEFENSE Defense Acquisition Regulations System [Docket Number DARS-2013-0038] Information Collection Requirement; Defense Federal Acquisition Regulation Supplement; Publicizing Contract Actions AGENCY: Defense Acquisition Regulation System, Department of Defense (DoD). ACTION: Notice and...

76 FR 72916 - Information Collection Requirement; Defense Federal Acquisition Regulation Supplement...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-28

... DEPARTMENT OF DEFENSE Defense Acquisition Regulations System [OMB Control Number 0704-0454] Information Collection Requirement; Defense Federal Acquisition Regulation Supplement; Administrative Matters AGENCY: Defense Acquisition Regulations System, Department of Defense (DoD). ACTION: Notice; request for...

78 FR 70294 - Information Collection Requirement; Defense Federal Acquisition Regulation Supplement...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-11-25

... DEPARTMENT OF DEFENSE Defense Acquisition Regulations System [Docket Number DARS 2013-0046] Information Collection Requirement; Defense Federal Acquisition Regulation Supplement; Administrative Matters AGENCY: Defense Acquisition Regulations System, Department of Defense (DoD). ACTION: Notice and request...

Cost of space-based laser ballistic missile defense.

PubMed

Field, G; Spergel, D

1986-03-21

Orbiting platforms carrying infrared lasers have been proposed as weapons forming the first tier of a ballistic missile defense system under the President's Strategic Defense Initiative. As each laser platform can destroy a limited number of missiles, one of several methods of countering such a system is to increase the number of offensive missiles. Hence it is important to know whether the cost-exchange ratio, defined as the ratio of the cost to the defense of destroying a missile to the cost to the offense of deploying an additional missile, is greater or less than 1. Although the technology to be used in a ballistic missile defense system is still extremely uncertain, it is useful to examine methods for calculating the cost-exchange ratio. As an example, the cost of an orbiting infrared laser ballistic missile defense system employed against intercontinental ballistic missiles launched simultaneously from a small area is compared to the cost of additional offensive missiles. If one adopts lower limits to the costs for the defense and upper limits to the costs for the offense, the cost-exchange ratio comes out substantially greater than 1. If these estimates are confirmed, such a ballistic missile defense system would be unable to maintain its effectiveness at less cost than it would take to proliferate the ballistic missiles necessary to overcome it and would therefore not satisfy the President's requirements for an effective strategic defense. Although the method is illustrated by applying it to a space-based infrared laser system, it should be straightforward to apply it to other proposed systems.

75 FR 47710 - TRICARE; Extended Care Health Option

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-09

... TRICARE; Extended Care Health Option AGENCY: Office of the Secretary, Department of Defense. ACTION: Final... Care Health Option (ECHO) from $2,500 per month to $36,000 per year, and for other non-legislated... services, inpatient and outpatient care, comprehensive home health care, respite care, and other services...

Systemic acquired resistance: turning local infection into global defense.

PubMed

Fu, Zheng Qing; Dong, Xinnian

2013-01-01

Systemic acquired resistance (SAR) is an induced immune mechanism in plants. Unlike vertebrate adaptive immunity, SAR is broad spectrum, with no specificity to the initial infection. An avirulent pathogen causing local programmed cell death can induce SAR through generation of mobile signals, accumulation of the defense hormone salicylic acid, and secretion of the antimicrobial PR (pathogenesis-related) proteins. Consequently, the rest of the plant is protected from secondary infection for a period of weeks to months. SAR can even be passed on to progeny through epigenetic regulation. The Arabidopsis NPR1 (nonexpresser of PR genes 1) protein is a master regulator of SAR. Recent study has shown that salicylic acid directly binds to the NPR1 adaptor proteins NPR3 and NPR4, regulates their interactions with NPR1, and controls NPR1 protein stability. However, how NPR1 interacts with TGA transcription factors to activate defense gene expression is still not well understood. In addition, redox regulators, the mediator complex, WRKY transcription factors, endoplasmic reticulum-resident proteins, and DNA repair proteins play critical roles in SAR.

Factors Influencing the Effectiveness of Systems Engineering Training and Education in the Department of Defense

DTIC Science & Technology

2011-04-30

learning. Recommendations are also presented for additional research into a more effective systems engineering andragogy . 15. SUBJECT TERMS 16...into a more effective systems engineering andragogy . Purpose Competency-based training for defense acquisition workers in the systems engineering

Antimicrobial peptides extend lifespan in Drosophila

PubMed Central

Mori, Tetsushi; Carrera, Pilar; Schroer, Jonas; Takeyama, Haruko

2017-01-01

Antimicrobial peptides (AMPs) are important defense molecules of the innate immune system. High levels of AMPs are induced in response to infections to fight pathogens, whereas moderate levels induced by metabolic stress are thought to shape commensal microbial communities at barrier tissues. We expressed single AMPs in adult flies either ubiquitously or in the gut by using the inducible GeneSwitch system to tightly regulate AMP expression. We found that activation of single AMPs, including Drosocin, resulted in a significant extension of Drosophila lifespan. These animals showed reduced activity of immune pathways over lifetime, less intestinal regenerative processes, reduced stress response and a delayed loss of gut barrier integrity. Furthermore, intestinal Drosocin induction protected the animals against infections with the natural Drosophila pathogen Pseudomonas entomophila, whereas a germ-reduced environment prevented the lifespan extending effect of Drosocin. Our study provides new insights into the crosstalk of innate immunity, intestinal homeostasis and ageing. PMID:28520752

Antimicrobial peptides extend lifespan in Drosophila.

PubMed

Loch, Gerrit; Zinke, Ingo; Mori, Tetsushi; Carrera, Pilar; Schroer, Jonas; Takeyama, Haruko; Hoch, Michael

2017-01-01

Antimicrobial peptides (AMPs) are important defense molecules of the innate immune system. High levels of AMPs are induced in response to infections to fight pathogens, whereas moderate levels induced by metabolic stress are thought to shape commensal microbial communities at barrier tissues. We expressed single AMPs in adult flies either ubiquitously or in the gut by using the inducible GeneSwitch system to tightly regulate AMP expression. We found that activation of single AMPs, including Drosocin, resulted in a significant extension of Drosophila lifespan. These animals showed reduced activity of immune pathways over lifetime, less intestinal regenerative processes, reduced stress response and a delayed loss of gut barrier integrity. Furthermore, intestinal Drosocin induction protected the animals against infections with the natural Drosophila pathogen Pseudomonas entomophila, whereas a germ-reduced environment prevented the lifespan extending effect of Drosocin. Our study provides new insights into the crosstalk of innate immunity, intestinal homeostasis and ageing.

Variation in plant defense suppresses herbivore performance

USGS Publications Warehouse

Pearse, Ian; Paul, Ryan; Ode, Paul J.

2018-01-01

Defensive variability of crops and natural systems can alter herbivore communities and reduce herbivory. However, it is still unknown how defense variability translates into herbivore suppression. Nonlinear averaging and constraints in physiological tracking (also more generally called time-dependent effects) are the two mechanisms by which defense variability might impact herbivores. We conducted a set of experiments manipulating the mean and variability of a plant defense, showing that defense variability does suppress herbivore performance and that it does so through physiological tracking effects that cannot be explained by nonlinear averaging. While nonlinear averaging predicted higher or the same herbivore performance on a variable defense than on an invariable defense, we show that variability actually decreased herbivore performance and population growth rate. Defense variability reduces herbivore performance in a way that is more than the average of its parts. This is consistent with constraints in physiological matching of detoxification systems for herbivores experiencing variable toxin levels in their diet and represents a more generalizable way of understanding the impacts of variability on herbivory. Increasing defense variability in croplands at a scale encountered by individual herbivores can suppress herbivory, even if that is not anticipated by nonlinear averaging.

Defense Workforce Training Programs.

ERIC Educational Resources Information Center

Fletcher, J. D.; And Others

This report discusses the amount and kinds of Department of Defense (DoD) interactive courseware (ICW) programs that are candidates for transfer to the private sector. Candidates for transfer were identified through an analysis of the Defense Instructional Technology Information System (DITIS). Out of 4,644 ICW programs that have been reported to…

Defense Logistics Agency Did Not Obtain Fair and Reasonable Prices From Meggitt Aircraft Braking Systems for Sole-Source Commercial Spare Parts (REDACTED)

DTIC Science & Technology

2015-05-08

Defense Logistics Agency Did Not Obtain Fair and Reasonable Prices From Meggitt Aircraft Braking Systems for Sole-Source Commercial Spare Parts...Defense Logistics Agency Did Not Obtain Fair and Reasonable Prices From Meggitt Aircraft Braking Systems for Sole-Source Commercial Spare Parts...D000AH-0180.000) │ i Results in Brief Defense Logistics Agency Did Not Obtain Fair and Reasonable Prices From Meggitt Aircraft Braking Systems for

Program Manager: Journal of the Defense Systems Management College, Volume 21, Number 3, May-June 1992

DTIC Science & Technology

1992-05-01

one manager -to-player inter- coaching styles are being used in tions do best with structured and actions, which diminish as each these outside...May-june 1992’ MANAGER Journal of the Defense Systems Management College Program management ,teI hIN be pl~ vrb~c aeese and sole; its 92-19864 92 7...23 l 9~3 PROGRAM MANAGER Journal of the Defense Systems Management College Vol. XXI, No. 3, DSMC 108 2 8 Is There Going to Be a High- Rebuilding the

76 FR 36905 - Information Collection Requirement; Defense Federal Acquisition Regulation Supplement; Taxes

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2011-06-23

... DEPARTMENT OF DEFENSE Defense Acquisition Regulations System Information Collection Requirement; Defense Federal Acquisition Regulation Supplement; Taxes AGENCY: Defense Acquisition Regulations System, Department of Defense (DoD). [[Page 36906

Dectin-1 plays an important role in host defense against systemic Candida glabrata infection.

PubMed

Chen, Si Min; Shen, Hui; Zhang, Teng; Huang, Xin; Liu, Xiao Qi; Guo, Shi Yu; Zhao, Jing Jun; Wang, Chun Fang; Yan, Lan; Xu, Guo Tong; Jiang, Yuan Ying; An, Mao Mao

2017-11-17

Candida glabrata is the second most common pathogen of severe candidiasis in immunocompromised hosts, following C. albicans. Although C. glabrata and C. albicans belong to the same genus, they are phylogenetically distinct. C-type lectin receptors (CLRs), acting as pattern-recognition receptors (PRRs), play critical roles in host defense against C. albicans infections. However, our understanding of the specific roles of CLRs in host defense against C. glabrata is limited. Here, we explored the potential roles of the C-type lectins Dectin-1 and Dectin-2 in host defense against C. glabrata. We found that both Dectin-1-deficient mice (Dectin-1 -/- ) and Dectin-2-deficient mice (Dectin-2 -/- ) are more susceptible to C. glabrata infection. Dectin-1confers host higher sensitivity for sensing C. glabrata infections, while the effect of Dectin-2 in the host defense against C. glabrata is infection dose dependent. Dectin-1 is required for host myeloid cells recognition, killing of C. glabrata, and development of subsequent Th1 and Th17 cell-mediated adaptive immune response. Significantly impaired inflammatory responses such as inflammatory cells recruitment and cytokines release that were induced by C. glabrata were manifested in Dectin-1-deficient mice. Together, our study demonstrates that Dectin-1 plays an important role in host defense against systemic Candida glabrata infections, indicating a previous unknown control mechanism for this particular type of infection in host. Our study, therefore, provides new insights into the host defense against C. glabrata.

External Quality Control Review of the Defense Information Systems Agency Audit Organization

DTIC Science & Technology

2012-08-07

We are providing this report for your information and use. We have reviewed the system of quality control for the audit organization of the Defense...audit organization encompasses the audit organization’s leadership, emphasis on performing high quality work, and policies and procedures established

The Mark of the Cognitive and the Coupling-Constitution Fallacy: A Defense of the Extended Mind Hypothesis.

PubMed

Piredda, Giulia

2017-01-01

Clark and Chalmers (1998) introduced the extended mind hypothesis, according to which some mental states can be realized by non-biological external resources. A lively debate has flourished around this hypothesis, connected with the issues of embodiment, embeddedness, situatedness and enaction (cf. Clark, 2008; Menary, 2010; Shapiro, 2011). Two of the main criticisms addressed to the functionalist version of the extended mind thesis have been the so-called "coupling-constitution fallacy" and the alleged lack of a mark of the cognitive (Adams and Aizawa, 2001, 2005, 2009, 2010a,b). According to Adams and Aizawa, extended cognition is a logical possibility, but is not instantiated in our world. Following this view, they defend a "contingent intracranialism," based on a specific mark of the cognitive that they propose. In this paper I intend to show that neither criticism is effective against the extended cognition thesis. In particular: the mark of the cognitive proposed by Adams and Aizawa does not secure contingent intracranialism;the coupling-constitution fallacy criticizes extended cognition on precisely the point the theory was intended to defend: namely, that the best way to individuate cognitive systems, given a minimal mark of the cognitive, is to rely on coupling relations between agents and environmental resources.

The Mark of the Cognitive and the Coupling-Constitution Fallacy: A Defense of the Extended Mind Hypothesis

PubMed Central

Piredda, Giulia

2017-01-01

Clark and Chalmers (1998) introduced the extended mind hypothesis, according to which some mental states can be realized by non-biological external resources. A lively debate has flourished around this hypothesis, connected with the issues of embodiment, embeddedness, situatedness and enaction (cf. Clark, 2008; Menary, 2010; Shapiro, 2011). Two of the main criticisms addressed to the functionalist version of the extended mind thesis have been the so-called “coupling-constitution fallacy” and the alleged lack of a mark of the cognitive (Adams and Aizawa, 2001, 2005, 2009, 2010a,b). According to Adams and Aizawa, extended cognition is a logical possibility, but is not instantiated in our world. Following this view, they defend a “contingent intracranialism,” based on a specific mark of the cognitive that they propose. In this paper I intend to show that neither criticism is effective against the extended cognition thesis. In particular: the mark of the cognitive proposed by Adams and Aizawa does not secure contingent intracranialism;the coupling-constitution fallacy criticizes extended cognition on precisely the point the theory was intended to defend: namely, that the best way to individuate cognitive systems, given a minimal mark of the cognitive, is to rely on coupling relations between agents and environmental resources. PMID:29234294

Plant Defense against Insect Herbivores

PubMed Central

Fürstenberg-Hägg, Joel; Zagrobelny, Mika; Bak, Søren

2013-01-01

Plants have been interacting with insects for several hundred million years, leading to complex defense approaches against various insect feeding strategies. Some defenses are constitutive while others are induced, although the insecticidal defense compound or protein classes are often similar. Insect herbivory induce several internal signals from the wounded tissues, including calcium ion fluxes, phosphorylation cascades and systemic- and jasmonate signaling. These are perceived in undamaged tissues, which thereafter reinforce their defense by producing different, mostly low molecular weight, defense compounds. These bioactive specialized plant defense compounds may repel or intoxicate insects, while defense proteins often interfere with their digestion. Volatiles are released upon herbivory to repel herbivores, attract predators or for communication between leaves or plants, and to induce defense responses. Plants also apply morphological features like waxes, trichomes and latices to make the feeding more difficult for the insects. Extrafloral nectar, food bodies and nesting or refuge sites are produced to accommodate and feed the predators of the herbivores. Meanwhile, herbivorous insects have adapted to resist plant defenses, and in some cases even sequester the compounds and reuse them in their own defense. Both plant defense and insect adaptation involve metabolic costs, so most plant-insect interactions reach a stand-off, where both host and herbivore survive although their development is suboptimal. PMID:23681010

Cost of space-based laser ballistic missile defense

DOE Office of Scientific and Technical Information (OSTI.GOV)

Field, G.; Spergel, D.

1986-03-21

Orbiting platforms carrying infrared lasers have been proposed as weapons forming the first tier of a ballistic missile defense system under the President's Strategic Defense Initiative. As each laser platform can destroy a limited number of missiles, one of several methods of countering such a system is to increase the number of offensive missiles. Hence it is important to know whether the cost-exchange ratio, defined as the ratio of the cost to the defense of destroying a missile to the cost to the offense of deploying an additional missile, is greater or less than 1. Although the technology to bemore » used in a ballistic missile defense system is still extremely uncertain, it is useful to examine methods for calculating the cost-exchange ration. As an example, the cost of an orbiting infrared laser ballistic missile defense system employed against intercontinental ballistic missiles launched simultaneously from a small area is compared to the cost of additional offensive missiles. If one adopts lower limits to the costs for the defense and upper limits to the costs for the offense, the cost-exchange ratio comes out substantially greater than 1. If these estimates are confirmed, such a ballistic missile defense system would be unable to maintain its effectiveness at less cost than it would take to proliferate the ballistic missiles necessary to overcome it and would therefore not satisfy the President's requirements for an effective strategic defense. Although the method is illustrated by applying it to a space-based infrared laser system, it should be straightforward to apply it to other proposed systems. 28 references, 2 tables.« less

Life History Traits of an Extended Longevity Phenotype of Drosophila melanogaster.

PubMed

Deepashree, S; Shivanandappa, T; Ramesh, S R

2017-01-01

Aging or senescence is a complex biological phenomenon. Artificially selected Drosophila for extended longevity is one of the experimental models used to understand the mechanisms involved in aging and to test various theories. To examine the life history traits and biochemical defenses in relation to aging in an extended longevity phenotype of Drosophila melanogaster. Life history traits viz., survivability, fecundity, development time, dry weight, wing size, lipid content, starvation, desiccation and cold resistances, locomotory ability, antioxidant enzyme activities and reactive oxygen species level between control and selected lines of D. melanogaster were investigated. In our model of Drosophila, extended longevity is associated with no trade-off in fecundity and shows variable resistance to environmental stress such as starvation, cold and desiccation. Enhanced biochemical defense involving the antioxidant enzymes was positively correlated with longevity. Extended longevity phenotypes of Drosophila represent genomic plasticity associated with variable life history traits attributed to the genetic background of the progenitor population and the environment of selection. Oxidative stress resistance seems to be a significant factor in longevity. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

Molecular Dynamics Simulation and Statistics Analysis Reveals the Defense Response Mechanism in Plants

NASA Astrophysics Data System (ADS)

Liu, Zhichao; Zhao, Yunjie; Zeng, Chen; Computational Biophysics Lab Team

As the main protein of the bacterial flagella, flagellin plays an important role in perception and defense response. The newly discovered locus, FLS2, is ubiquitously expressed. FLS2 encodes a putative receptor kinase and shares many homologies with some plant resistance genes and even with some components of immune system of mammals and insects. In Arabidopsis, FLS2 perception is achieved by the recognition of epitope flg22, which induces FLS2 heteromerization with BAK1 and finally the plant immunity. Here we use both analytical methods such as Direct Coupling Analysis (DCA) and Molecular Dynamics (MD) Simulations to get a better understanding of the defense mechanism of FLS2. This may facilitate a redesign of flg22 or de-novo design for desired specificity and potency to extend the immune properties of FLS2 to other important crops and vegetables.

Joint Land Attack Cruise Missile Defense Elevated Netted Sensor System Not Ready for Production Decision (REDACTED)

DTIC Science & Technology

2012-09-07

Average Procurement Unit Cost CMDS Cruise Missile Defense Systems CPD Capability Production Document EMD Engineering and Manufacturing...Defense for Acquisition, Technology and Logistics also determined that continuing test and evaluation of the two JLENS Engineering and Manufacturing...Program (Category ID) that was established in January 1996 and, during the audit, was in the Engineering and Manufacturing Development (EMD) phase of

Silverleaf Whitefly Induces Salicylic Acid Defenses and Suppresses Effectual Jasmonic Acid Defenses1[W][OA

PubMed Central

Zarate, Sonia I.; Kempema, Louisa A.; Walling, Linda L.

2007-01-01

The basal defenses important in curtailing the development of the phloem-feeding silverleaf whitefly (Bemisia tabaci type B; SLWF) on Arabidopsis (Arabidopsis thaliana) were investigated. Sentinel defense gene RNAs were monitored in SLWF-infested and control plants. Salicylic acid (SA)-responsive gene transcripts accumulated locally (PR1, BGL2, PR5, SID2, EDS5, PAD4) and systemically (PR1, BGL2, PR5) during SLWF nymph feeding. In contrast, jasmonic acid (JA)- and ethylene-dependent RNAs (PDF1.2, VSP1, HEL, THI2.1, FAD3, ERS1, ERF1) were repressed or not modulated in SLWF-infested leaves. To test for a role of SA and JA pathways in basal defense, SLWF development on mutant and transgenic lines that constitutively activate or impair defense pathways was determined. By monitoring the percentage of SLWF nymphs in each instar, we show that mutants that activate SA defenses (cim10) or impair JA defenses (coi1) accelerated SLWF nymphal development. Reciprocally, mutants that activate JA defenses (cev1) or impair SA defenses (npr1, NahG) slowed SLWF nymphal development. Furthermore, when npr1 plants, which do not activate downstream SA defenses, were treated with methyl jasmonate, a dramatic delay in nymph development was observed. Collectively, these results showed that SLWF-repressed, JA-regulated defenses were associated with basal defense to the SLWF. PMID:17189328

Photovoltaics in the Department of Defense

NASA Astrophysics Data System (ADS)

Chapman, Richard N.

1997-02-01

This paper documents the history of photovoltaic use within the Department of Defense leading up to the installation of 2.1 MW of photovoltaics underway today. This history describes the evolution of the Department of Defense's Tri-Service Photovoltaic Review Committee and the committee's strategic plan to realize photovoltaic's full potential through outreach, conditioning of the federal procurement system, and specific project development. The Photovoltaic Review Committee estimates photovoltaic's potential at nearly 4,000 MW, of which about 700 MW are considered to be cost-effective at today's prices. The paper describes photovoltaic's potential within the Department of Defense, the status and features of the 2.1-MW worth of photovoltaic systems under installation, and how these systems are selected and implemented. The paper also documents support provided to the Department of Defense by the Department of Energy dating back to the late 70s.

Self-Assembly of Multi-nanozymes to Mimic an Intracellular Antioxidant Defense System.

PubMed

Huang, Yanyan; Liu, Zhen; Liu, Chaoqun; Ju, Enguo; Zhang, Yan; Ren, Jinsong; Qu, Xiaogang

2016-06-01

In this work, for the first time, we constructed a novel multi-nanozymes cooperative platform to mimic intracellular antioxidant enzyme-based defense system. V2 O5 nanowire served as a glutathione peroxidase (GPx) mimic while MnO2 nanoparticle was used to mimic superoxide dismutase (SOD) and catalase (CAT). Dopamine was used as a linker to achieve the assembling of the nanomaterials. The obtained V2 O5 @pDA@MnO2 nanocomposite could serve as one multi-nanozyme model to mimic intracellular antioxidant enzyme-based defense procedure in which, for example SOD, CAT, and GPx co-participate. In addition, through assembling with dopamine, the hybrid nanocomposites provided synergistic antioxidative effect. Importantly, both in vitro and in vivo experiments demonstrated that our biocompatible system exhibited excellent intracellular reactive oxygen species (ROS) removal ability to protect cell components against oxidative stress, showing its potential application in inflammation therapy. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Variation in Plant Defense Suppresses Herbivore Performance.

PubMed

Pearse, Ian S; Paul, Ryan; Ode, Paul J

2018-06-18

Defensive variability of crops and natural systems can alter herbivore communities and reduce herbivory [1, 2]. However, it is still unknown how defense variability translates into herbivore suppression. Nonlinear averaging and constraints in physiological tracking (also more generally called time-dependent effects) are the two mechanisms by which defense variability might impact herbivores [3, 4]. We conducted a set of experiments manipulating the mean and variability of a plant defense, showing that defense variability does suppress herbivore performance and that it does so through physiological tracking effects that cannot be explained by nonlinear averaging. While nonlinear averaging predicted higher or the same herbivore performance on a variable defense than on an invariable defense, we show that variability actually decreased herbivore performance and population growth rate. Defense variability reduces herbivore performance in a way that is more than the average of its parts. This is consistent with constraints in physiological matching of detoxification systems for herbivores experiencing variable toxin levels in their diet and represents a more generalizable way of understanding the impacts of variability on herbivory [5]. Increasing defense variability in croplands at a scale encountered by individual herbivores can suppress herbivory, even if that is not anticipated by nonlinear averaging. Published by Elsevier Ltd.

Use of the CRISPR/Cas9 system as an intracellular defense against HIV-1 infection in human cells.

PubMed

Liao, Hsin-Kai; Gu, Ying; Diaz, Arturo; Marlett, John; Takahashi, Yuta; Li, Mo; Suzuki, Keiichiro; Xu, Ruo; Hishida, Tomoaki; Chang, Chan-Jung; Esteban, Concepcion Rodriguez; Young, John; Izpisua Belmonte, Juan Carlos

2015-03-10

To combat hostile viruses, bacteria and archaea have evolved a unique antiviral defense system composed of clustered regularly interspaced short palindromic repeats (CRISPRs), together with CRISPR-associated genes (Cas). The CRISPR/Cas9 system develops an adaptive immune resistance to foreign plasmids and viruses by creating site-specific DNA double-stranded breaks (DSBs). Here we adapt the CRISPR/Cas9 system to human cells for intracellular defense against foreign DNA and viruses. Using HIV-1 infection as a model, our results demonstrate that the CRISPR/Cas9 system disrupts latently integrated viral genome and provides long-term adaptive defense against new viral infection, expression and replication in human cells. We show that engineered human-induced pluripotent stem cells stably expressing HIV-targeted CRISPR/Cas9 can be efficiently differentiated into HIV reservoir cell types and maintain their resistance to HIV-1 challenge. These results unveil the potential of the CRISPR/Cas9 system as a new therapeutic strategy against viral infections.

Department of Defense Chemical and Biological Defense Program. Annual Report to Congress

DTIC Science & Technology

2008-05-01

defense system acquisition costs through collaboration in the areas of development, production , and support, and to enhance interoperability with...security area leverages S&T efforts of the other product areas. Where unmet requirements are identified and where S&T is required to meet cost ...Defense Program Inventory Requirements The industrial base, which has scaled down since the end of the Cold War, has stabilized. Ongoing military

78 FR 68830 - Information Collection Requirement; Defense Federal Acquisition Regulation Supplement; Service...

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Relationships between U.S. Naval Observatory, LORAN-C and the Defense Satellite Communication System

NASA Technical Reports Server (NTRS)

Charron, L. G.

1982-01-01

The methods used in forming time scales for distant sites monitoring LORAN-C are addressed. The time transfers obtained via the defense satellite communication system (DSCS) and the data provided by this system used to calibrate these remote time scales are emphasized. The errors involved are discussed.

Development of System Architecture to Investigate the Impact of Integrated Air and Missile Defense in a Distributed Lethality Environment

DTIC Science & Technology

2017-12-01

SYSTEM ARCHITECTURE TO INVESTIGATE THE IMPACT OF INTEGRATED AIR AND MISSILE DEFENSE IN A DISTRIBUTED LETHALITY ENVIRONMENT by Justin K. Davis...TO INVESTIGATE THE IMPACT OF INTEGRATED AIR AND MISSILE DEFENSE IN A DISTRIBUTED LETHALITY ENVIRONMENT 5. FUNDING NUMBERS 6. AUTHOR(S) Justin K...ARCHITECTURE TO INVESTIGATE THE IMPACT OF INTEGRATED AIR AND MISSILE DEFENSE IN A DISTRIBUTED LETHALITY ENVIRONMENT Justin K. Davis Lieutenant

78 FR 67132 - Information Collection Requirement; Defense Federal Acquisition Regulation Supplement; Contract...

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2013-11-08

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75 FR 45104 - Information Collection Requirement; Defense Federal Acquisition Regulation Supplement; Contract...

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2010-08-02

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Sweet Tetra-Trophic Interactions: Multiple Evolution of Nectar Secretion, a Defensive Extended Phenotype in Cynipid Gall Wasps.

PubMed

Nicholls, James A; Melika, George; Stone, Graham N

2017-01-01

Many herbivores employ reward-based mutualisms with ants to gain protection from natural enemies. We examine the evolutionary dynamics of a tetra-trophic interaction in which gall wasp herbivores induce their host oaks to produce nectar-secreting galls, which attract ants that provide protection from parasitoids. We show that, consistent with other gall defensive traits, nectar secretion has evolved repeatedly across the oak gall wasp tribe and also within a single genus (Disholcaspis) that includes many nectar-inducing species. Once evolved, nectar secretion is never lost in Disholcaspis, consistent with high defensive value of this trait. We also show that evolution of nectar secretion is correlated with a transition from solitary to aggregated oviposition, resulting in clustered nectar-secreting galls, which produce a resource that ants can more easily monopolize. Such clustering is commonly seen in ant guard mutualisms. We suggest that correlated evolution between maternal oviposition and larval nectar induction traits has enhanced the effectiveness of this gall defense strategy.

Stochastic model for threat assessment in multi-sensor defense system

NASA Astrophysics Data System (ADS)

Wang, Yongcheng; Wang, Hongfei; Jiang, Changsheng

2007-11-01

This paper puts forward a stochastic model for target detecting and tracking in multi-sensor defense systems and applies the Lanchester differential equations to threat assessment in combat. The two different modes of targets tracking and their respective Lanchester differential equations are analyzed and established. By use of these equations, we could briefly estimate the loss of each combat side and accordingly get the threat estimation results, given the situation analysis is accomplished.

Systemic Adenosine Triphosphate Impairs Neutrophil Chemotaxis and Host Defense in Sepsis.

PubMed

Li, Xiaoou; Kondo, Yutaka; Bao, Yi; Staudenmaier, Laura; Lee, Albert; Zhang, Jingping; Ledderose, Carola; Junger, Wolfgang G

2017-01-01

Sepsis remains an unresolved clinical problem. Therapeutic strategies focusing on inhibition of neutrophils (polymorphonuclear neutrophils) have failed, which indicates that a more detailed understanding of the underlying pathophysiology of sepsis is required. Polymorphonuclear neutrophil activation and chemotaxis require cellular adenosine triphosphate release via pannexin-1 channels that fuel autocrine feedback via purinergic receptors. In the current study, we examined the roles of endogenous and systemic adenosine triphosphate on polymorphonuclear neutrophil activation and host defense in sepsis. Prospective randomized animal investigation and in vitro studies. Preclinical academic research laboratory. Wild-type C57BL/6 mice, pannexin-1 knockout mice, and healthy human subjects used to obtain polymorphonuclear neutrophils for in vitro studies. Wild-type and pannexin-1 knockout mice were treated with suramin or apyrase to block the endogenous or systemic effects of adenosine triphosphate. Mice were subjected to cecal ligation and puncture and polymorphonuclear neutrophil activation (CD11b integrin expression), organ (liver) injury (plasma aspartate aminotransferase), bacterial spread, and survival were monitored. Human polymorphonuclear neutrophils were used to study the effect of systemic adenosine triphosphate and apyrase on chemotaxis. Inhibiting endogenous adenosine triphosphate reduced polymorphonuclear neutrophil activation and organ injury, but increased the spread of bacteria and mortality in sepsis. By contrast, removal of systemic adenosine triphosphate improved bacterial clearance and survival in sepsis by improving polymorphonuclear neutrophil chemotaxis. Systemic adenosine triphosphate impairs polymorphonuclear neutrophil functions by disrupting the endogenous purinergic signaling mechanisms that regulate cell activation and chemotaxis. Removal of systemic adenosine triphosphate improves polymorphonuclear neutrophil function and host defenses

Testicular defense systems: immune privilege and innate immunity

PubMed Central

Zhao, Shutao; Zhu, Weiwei; Xue, Shepu; Han, Daishu

2014-01-01

The mammalian testis possesses a special immunological environment because of its properties of remarkable immune privilege and effective local innate immunity. Testicular immune privilege protects immunogenic germ cells from systemic immune attack, and local innate immunity is important in preventing testicular microbial infections. The breakdown of local testicular immune homeostasis may lead to orchitis, an etiological factor of male infertility. The mechanisms underlying testicular immune privilege have been investigated for a long time. Increasing evidence shows that both a local immunosuppressive milieu and systemic immune tolerance are involved in maintaining testicular immune privilege status. The mechanisms underlying testicular innate immunity are emerging based on the investigation of the pattern recognition receptor-mediated innate immune response in testicular cells. This review summarizes our current understanding of testicular defense mechanisms and identifies topics that merit further investigation. PMID:24954222

Defenses and morality: Adam Smith, Sigmund Freud, and contemporary psychoanalysis.

PubMed

Gabrinetti, Paul A; Özler, Sule

2014-10-01

In this paper we follow the development and transmission of moral learning from Adam Smith's impartial spectator to Sigmund Freud's superego and then to contemporary psychoanalysis. We argue that defenses are an integral component in the acquisition of any moral system. Elaborating on this argument, we assert that there is a progression from defensive systems that are "closed" to defensive systems that are "open," as defined in a recent work by Novick and Novick. The former system is "static, avoids reality, and is characterized by power dynamics, sadomasochism, and omnipotent defense." The latter, on the other hand, is a system that allows for "joy, creativity, spontaneity, love and it is attuned to reality." Furthermore, while Smith and Freud's systems are more one-person systems of defense, contemporary psychoanalysis has moved to more of a two-person system.

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Code of Federal Regulations, 2013 CFR

2013-04-01

... 22 Foreign Relations 1 2013-04-01 2013-04-01 false Defense articles and defense services. 130.4 Section 130.4 Foreign Relations DEPARTMENT OF STATE INTERNATIONAL TRAFFIC IN ARMS REGULATIONS POLITICAL CONTRIBUTIONS, FEES AND COMMISSIONS § 130.4 Defense articles and defense services. Defense articles and defense...

22 CFR 130.4 - Defense articles and defense services.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Defense articles and defense services. 130.4 Section 130.4 Foreign Relations DEPARTMENT OF STATE INTERNATIONAL TRAFFIC IN ARMS REGULATIONS POLITICAL CONTRIBUTIONS, FEES AND COMMISSIONS § 130.4 Defense articles and defense services. Defense articles and defense...

22 CFR 130.4 - Defense articles and defense services.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 22 Foreign Relations 1 2011-04-01 2011-04-01 false Defense articles and defense services. 130.4 Section 130.4 Foreign Relations DEPARTMENT OF STATE INTERNATIONAL TRAFFIC IN ARMS REGULATIONS POLITICAL CONTRIBUTIONS, FEES AND COMMISSIONS § 130.4 Defense articles and defense services. Defense articles and defense...

75 FR 48278 - Defense Federal Acquisition Regulation Supplement; Excessive Pass-Through Charges

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-10

... DEPARTMENT OF DEFENSE Defense Acquisition Regulations System 48 CFR Parts 215, 231, and 252 [DFARS Case 2006-D057] Defense Federal Acquisition Regulation Supplement; Excessive Pass-Through Charges AGENCY: Defense Acquisition Regulations System, Department of Defense (DoD). ACTION: Final rule. SUMMARY...

Feasibility Study for a Computerized Serials Control System in the Defense Communications Agency Technical and Management Information Center.

DTIC Science & Technology

1984-06-20

AD-A162 ±88 FEASIBILITY STUDY FOR A COMPUTERIZED SERIALS CONTROL 1/1 SYSTEM IN THE DEFENS (U) DEFENSE COMMUNICATIONS AGENCY WASHINGTON DC TECHNICAL...NATIONAL BUREAU OF STANDARDS- 1963-A 0FEASIBILITY STUDY FOR A COMPUTERIZED SERIALS CONTROL SYSTEM IN THE DEFENSE COMMUNICATIONS 0AGENCY TECHNICAL AND...ABSTRACT 21. ABSTRACT SECURITY CLASSIFICATION UNCLASSIFIED/UNLIMITED R1 SAME AS RPT. 0 DTIC USERS 0 UNCLASSIFIED 22&. NAME OF RESPONSIBLE INDIVIDUAL 22b

77 FR 58817 - Information Collection Requirement; Defense Federal Acquisition Regulation Supplement (DFARS...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-09-24

... DEPARTMENT OF DEFENSE Defense Acquisition Regulations System [OMB Control Number 0704-0321... Financing AGENCY: Defense Acquisition Regulations System, Department of Defense (DoD). ACTION: Notice and... . Paper copies are available from Mr. Mark Gomersall, OUSD(AT&L) DPAP/DARS, Room 3B855, 3060 Defense...

Integrated Air and Missile Defense (IAMD)

DTIC Science & Technology

2015-12-01

equal to or greater than the effectiveness levels of fielded TBM and CM/ABT defense systems. Common Command and Control The Army IAMD SoS common C2...externally developed sensors and shooters to provide an effective IAMD capability. The IAMD program will allow transformation to a network-centric system of...systems capability, also referred to as "Plug and Fight", that integrates all Air and Missile Defense (AMD) sensors, weapons, and mission control

Radiological Defense. Planning and Operations Guide. Revised.

ERIC Educational Resources Information Center

Office of Civil Defense (DOD), Washington, DC.

This guide is a reprint of published and draft materials from the Federal Civil Defense Guide. This guide is intended to assist the student in planning, developing, implementing and operating a local, county, or state radiological defense (RADEF) system. The state and local radiological defense program objectives are to create an effective and…

76 FR 20336 - Defense Audit Advisory Committee (DAAC)

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-12

... DEPARTMENT OF DEFENSE Office of the Secretary Defense Audit Advisory Committee (DAAC) AGENCY... following Federal advisory committee meeting of the Defense Audit Advisory Committee will be held. DATES... management to include financial reporting processes, systems of internal controls, audit processes, and...

76 FR 52131 - Defense Federal Acquisition Regulation Supplement; Nonavailability Exception for Procurement of...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-19

... Vol. 76 Friday, No. 161 August 19, 2011 Part III Department of Defense Defense Acquisition Regulations System 48 CFR Parts 201, 209, 216, et al. Defense Federal Acquisition Regulation Supplements... DEFENSE Defense Acquisition Regulations System 48 CFR Part 225 RIN 0750-AH17 Defense Federal Acquisition...

Macroevolutionary patterns of glucosinolate defense and tests of defense-escalation and resource availability hypotheses.

PubMed

Cacho, N Ivalú; Kliebenstein, Daniel J; Strauss, Sharon Y

2015-11-01

We explored macroevolutionary patterns of plant chemical defense in Streptanthus (Brassicaceae), tested for evolutionary escalation of defense, as predicted by Ehrlich and Raven's plant-herbivore coevolutionary arms-race hypothesis, and tested whether species inhabiting low-resource or harsh environments invest more in defense, as predicted by the resource availability hypothesis (RAH). We conducted phylogenetically explicit analyses using glucosinolate profiles, soil nutrient analyses, and microhabitat bareness estimates across 30 species of Streptanthus inhabiting varied environments and soils. We found weak to moderate phylogenetic signal in glucosinolate classes and no signal in total glucosinolate production; a trend toward evolutionary de-escalation in the numbers and diversity of glucosinolates, accompanied by an evolutionary increase in the proportion of aliphatic glucosinolates; some support for the RAH relative to soil macronutrients, but not relative to serpentine soil use; and that the number of glucosinolates increases with microhabitat bareness, which is associated with increased herbivory and drought. Weak phylogenetic signal in chemical defense has been observed in other plant systems. A more holistic approach incorporating other forms of defense might be necessary to confidently reject escalation of defense. That defense increases with microhabitat bareness supports the hypothesis that habitat bareness is an underappreciated selective force on plants in harsh environments. © 2015 The Authors. New Phytologist © 2015 New Phytologist Trust.

Turnabout Is Fair Play: Herbivory-Induced Plant Chitinases Excreted in Fall Armyworm Frass Suppress Herbivore Defenses in Maize1[OPEN

PubMed Central

Alves, Patrick C.M.S.; Gaffoor, Iffa; Acevedo, Flor E.; Peiffer, Michelle; Jin, Shan; Han, Yang; Shakeel, Samina; Felton, Gary W.

2016-01-01

The perception of herbivory by plants is known to be triggered by the deposition of insect-derived factors such as saliva and oral secretions, oviposition materials, and even feces. Such insect-derived materials harbor chemical cues that may elicit herbivore and/or pathogen-induced defenses in plants. Several insect-derived molecules that trigger herbivore-induced defenses in plants are known; however, insect-derived molecules suppressing them are largely unknown. In this study, we identified two plant chitinases from fall armyworm (Spodoptera frugiperda) larval frass that suppress herbivore defenses while simultaneously inducing pathogen defenses in maize (Zea mays). Fall armyworm larvae feed in enclosed whorls of maize plants, where frass accumulates over extended periods of time in close proximity to damaged leaf tissue. Our study shows that maize chitinases, Pr4 and Endochitinase A, are induced during herbivory and subsequently deposited on the host with the feces. These plant chitinases mediate the suppression of herbivore-induced defenses, thereby increasing the performance of the insect on the host. Pr4 and Endochitinase A also trigger the antagonistic pathogen defense pathway in maize and suppress fungal pathogen growth on maize leaves. Frass-induced suppression of herbivore defenses by deposition of the plant-derived chitinases Pr4 and Endochitinase A is a unique way an insect can co-opt the plant’s defense proteins for its own benefit. It is also a phenomenon unlike the induction of herbivore defenses by insect oral secretions in most host-herbivore systems. PMID:26979328

Development of the Defense Documentation Center Remote On-Line Retrieval System - Past, Present and Future.

ERIC Educational Resources Information Center

Bennertz, Richard K.

The document highlights in nontechnical language the development of the Defense Documentation Center (DDC) Remote On-Line Retrieval System from its inception in 1967 to what is planned. It describes in detail the current operating system, equipment configuration and associated costs, user training and system evaluation and may be of value to other…

76 FR 50461 - Information Collection Requirement; Defense Federal Acquisition Regulation Supplement; Types of...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-15

... DEPARTMENT OF DEFENSE Defense Acquisition Regulations System [OMB Control Number 0704-0259] Information Collection Requirement; Defense Federal Acquisition Regulation Supplement; Types of Contracts AGENCY: Defense Acquisition Regulations System, Department of Defense (DoD). ACTION: Notice and request...

76 FR 71558 - Information Collection Requirement; Defense Federal Acquisition Regulation Supplement; Requests...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-18

... DEPARTMENT OF DEFENSE Defense Acquisition Regulations System [Docket No. DARS 2011-0069-0002] Information Collection Requirement; Defense Federal Acquisition Regulation Supplement; Requests for Equitable Adjustment (OMB Control Number 0704-0397) AGENCY: Defense Acquisition Regulations System, Department of...

75 FR 32122 - Revisions to Defense Priorities and Allocations System Regulations

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-07

...This proposed rule would reorganize and clarify existing standards and procedures by which the Bureau of Industry and Security (BIS) may require that certain contracts or orders that promote the national defense be given priority over other contracts or orders. This rule also sets new standards and procedures by which BIS may allocate materials, services and facilities to promote the national defense. BIS is publishing this rule to comply with a requirement of the Defense Production Act Reauthorization of 2009 to publish regulations providing standards and procedures for prioritization of contracts and orders and for allocation of materials, services and facilities to promote the national defense.

Cost Effective Regional Ballistic Missile Defense

DTIC Science & Technology

2016-02-16

deploying advanced air defense systems18, such as the Russian S-300 and S-500, and concealing them in hardened, camouflaged sites, such as extensive... Russian objections to the European Phased Adaptive Approach (EPAA) and fund homeland defense priorities.39 Furthermore, the PTSS system was also... Theatre Ballistic Missile Defence Capability Becomes Operational,” Jane’s Missiles & Rockets, 1 February 2011. 55 Joseph W. Kirschbaum, REGIONAL MISSILE

78 FR 18877 - Defense Federal Acquisition Regulation Supplement; Specialty Metals-Definition of “Produce...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-28

... DEPARTMENT OF DEFENSE Defense Acquisition Regulations System 48 CFR Part 252 RIN 0750-AH78 Defense...-D041) AGENCY: Defense Acquisition Regulations System, Department of Defense (DoD). ACTION: Final rule. SUMMARY: DoD is issuing a final rule amending the Defense Federal Acquisition Regulation Supplement (DFARS...

78 FR 33994 - Defense Federal Acquisition Regulation Supplement; Government Support Contractor Access to...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-06

... DEPARTMENT OF DEFENSE Defense Acquisition Regulations System 48 CFR Part 252 RIN Number 0750-AG38 Defense Federal Acquisition Regulation Supplement; Government Support Contractor Access to Technical Data (DFARS 2009-D031); Correction AGENCY: Defense Acquisition Regulations System, Department of Defense (DoD...

77 FR 52254 - Defense Federal Acquisition Regulation Supplement: Reporting of Government-Furnished Property...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-29

... DEPARTMENT OF DEFENSE Defense Acquisition Regulations System 48 CFR Parts 211, 212, and 252 RIN... (DFARS Case 2012-D001) AGENCY: Defense Acquisition Regulations System, Department of Defense (DoD... requirements of the current clause, which requires Defense contractors to report (primarily) Government...

78 FR 48397 - Defense Federal Acquisition Regulation Supplement: Clauses With Alternates-Transportation (DFARS...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-08

... DEPARTMENT OF DEFENSE Defense Acquisition Regulations System 48 CFR Parts 212, 216, 247, and 252...--Transportation (DFARS Case 2012-D057) AGENCY: Defense Acquisition Regulations System, Department of Defense (DoD... manufacture, fabrication, or assembly by the Contractor or any subcontractor. (2) ``Department of Defense...

Optimal defense strategies in an idealized microbial food web under trade-off between competition and defense.

PubMed

Våge, Selina; Storesund, Julia E; Giske, Jarl; Thingstad, T Frede

2014-01-01

Trophic mechanisms that can generate biodiversity in food webs include bottom-up (growth rate regulating) and top-down (biomass regulating) factors. The top-down control has traditionally been analyzed using the concepts of "Keystone Predation" (KP) and "Killing-the-Winner" (KtW), predominately occuring in discussions of macro- and micro-biological ecology, respectively. Here we combine the classical diamond-shaped food web structure frequently discussed in KP analyses and the KtW concept by introducing a defense strategist capable of partial defense. A formalized description of a trade-off between the defense-strategist's competitive and defensive ability is included. The analysis reveals a complex topology of the steady state solution with strong relationships between food web structure and the combination of trade-off, defense strategy and the system's nutrient content. Among the results is a difference in defense strategies corresponding to maximum biomass, production, or net growth rate of invading individuals. The analysis thus summons awareness that biomass or production, parameters typically measured in field studies to infer success of particular biota, are not directly acted upon by natural selection. Under coexistence with a competition specialist, a balance of competitive and defensive ability of the defense strategist was found to be evolutionarily stable, whereas stronger defense was optimal under increased nutrient levels in the absence of the pure competition specialist. The findings of success of different defense strategies are discussed with respect to SAR11, a highly successful bacterial clade in the pelagic ocean.

Racial disparity in survival from early breast cancer in the department of defense healthcare system.

PubMed

Rizzo, Julie A; Sherman, William E; Arciero, Cletus A

2015-06-01

Racial disparity is often identified as a factor in survival from breast cancer in the United States. Current data regarding survival in patients treated in the Department of Defense Military Healthcare System is lacking. The Department of Defense Automated Central Tumor Registry (ACTUR) was queried for all women diagnosed with Stage I or II breast cancer from January 1, 1996 through December 31, 2008. Statistical analyses evaluated demographics, surgical treatment, tumor stage, and survival rates. There were 8,890 patients meeting inclusion criteria. Patients who were younger, Asian American (versus white or black), lower T and/or N stage had significantly improved survival rates. Interestingly, white and black patients demonstrated similar survival in this study. Patients with a longer period of time between diagnosis and treatment had no decrement in survival. As would be expected, patients with a longer recurrence free period enjoyed longer survival. Survival from early stage breast cancer is equivalent between white and black patients in the Department of Defense Healthcare System. This finding is contrary to reports from our civilian counterparts and may be indicative of improved access to care and overall improved cancer surveillance. © 2015 Wiley Periodicals, Inc.

Conceptualizing death in a worldview consistent, meaningful way and its effects on worldview defense.

PubMed

Rogers, Ross

2011-02-01

Research within terror management theory (TMT) has shown that when mortality is made salient, people subsequently engage in worldview defense: an increase in derogation of an individual who does not share their worldview along with an increase in veneration of an individual who does. Research has also shown that high levels of self-esteem (either dispositionally possessed or artificially enhanced) or legitimization of one's meaning supplying system (worldview) can attenuate the increase in worldview defense typically seen after mortality salience. Extending these findings, this research examined the hypothesis that motivating participants to consider their mortality in a manner that was personally meaningful and thus consistent with their particular worldview would also serve to assuage the need for worldview defense. The research reported below supported this reasoning. Specifically, participants with a Christian religious background who were given the typical mortality salience prime produced more positive evaluations of a Christian target and more negative evaluations of a Jewish target. However, participants with a Christian religious background who were presented with a meaningful mortality salience induction produced evaluations of the Christian and Jewish targets that did not differ. The implications of conceptualizing death meaningfully are discussed.

Program Manager: Journal of the Defense Systems Management College. Volume 19, Number 5, September-October 1990

DTIC Science & Technology

1990-10-01

International Defense Cooperation Agreements; Quality Force Deployment; How Contractors See Systems Acquisition; DOD Metric Transition Plans and Actions; Proposals for Innovation In Service Quality . (sdw)

Electrodynamic tether system study: Extended study

NASA Technical Reports Server (NTRS)

1988-01-01

This document is the final report of a study performed by Ball Space Systems Division (BSSD) for the NASA Johnson Space Center under an extension to contract NAS9-17666. The tasks for the extended study were as follows: (1) Define an interface between the Electrodynamic Tether System (ETS) and the Space Station (SS); (2) Identify growth paths for the 100 kW ETS defined in the original study to a 200 kW level of performance; (3) Quantify orbit perturbations caused by cyclic day/night operations of a Plasma Motor/Generator (PMG) on the SS and explore methods of minimizing these effects; (4) Define the analyses, precursor technology, ground tests, and precursor demonstrations leading up to a demonstration mission for an electrodynamic tether system that would be capable of producing maneuvering thrust levels of 25 newtons; and (5) Propose a development schedule for the demonstration mission and preliminary cost estimates.

Review of defense display research programs

NASA Astrophysics Data System (ADS)

Tulis, Robert W.; Hopper, Darrel G.; Morton, David C.; Shashidhar, Ranganathan

2001-09-01

Display research has comprised a substantial portion of the defense investment in new technology for national security for the past 13 years. These investments have been made by the separate service departments and, especially, via several Defense Research Projects Agency (DARPA) programs, known collectively as the High Definition Systems (HDS) Program (which ended in 2001) and via the Office of the Secretary of Defense (OSD) Defense Production Act (DPA) Title III Program (efforts ended in 2000). Using input from the Army, Navy, and Air Force to focus research and identify insertion opportunities, DARPA and the Title III Program Office have made investments to develop the national technology base and manufacturing infrastructure necessary to meet the twin challenge of providing affordable displays in current systems and enabling the DoD strategy of winning future conflicts by getting more information to all participants during the battle. These completed DARPA and DPA research and infrastructure programs are reviewed. Service investments have been and are being made to transition display technology; examples are described. Display science and technology (S&T) visions are documented for each service to assist the identification of areas meriting consideration for future defense research.

48 CFR 228.102-70 - Defense Environmental Restoration Program construction contracts.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Restoration Program construction contracts. 228.102-70 Section 228.102-70 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE GENERAL CONTRACTING REQUIREMENTS BONDS AND INSURANCE Bonds 228.102-70 Defense Environmental Restoration Program construction contracts...

Estimating Power System Dynamic States Using Extended Kalman Filter

DOE Office of Scientific and Technical Information (OSTI.GOV)

Huang, Zhenyu; Schneider, Kevin P.; Nieplocha, Jaroslaw

2014-10-31

Abstract—The state estimation tools which are currently deployed in power system control rooms are based on a steady state assumption. As a result, the suite of operational tools that rely on state estimation results as inputs do not have dynamic information available and their accuracy is compromised. This paper investigates the application of Extended Kalman Filtering techniques for estimating dynamic states in the state estimation process. The new formulated “dynamic state estimation” includes true system dynamics reflected in differential equations, not like previously proposed “dynamic state estimation” which only considers the time-variant snapshots based on steady state modeling. This newmore » dynamic state estimation using Extended Kalman Filter has been successfully tested on a multi-machine system. Sensitivity studies with respect to noise levels, sampling rates, model errors, and parameter errors are presented as well to illustrate the robust performance of the developed dynamic state estimation process.« less

76 FR 64885 - Defense Federal Acquisition Regulation Supplement: Reporting of Government-Furnished Property...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-19

... property accounting system of record, and the Army requires GFP to be recorded in DPAS as well. Response... DEPARTMENT OF DEFENSE Defense Acquisition Regulations System 48 CFR Parts 211 and 252 RIN 0750... (DFARS Case 2012-D001) AGENCIES: Defense Acquisition Regulations System, Department of Defense (DoD...

77 FR 30366 - Defense Federal Acquisition Regulation Supplement: Contingency Contract Closeout (DFARS Case 2012...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-22

... DEPARTMENT OF DEFENSE Defense Acquisition Regulations System 48 CFR Part 204 RIN 0750-AH71 Defense...: Defense Acquisition Regulations System, Department of Defense (DoD). ACTION: Final rule. SUMMARY: DoD is issuing a final rule amending the Defense Federal Acquisition Regulation Supplement (DFARS) to require...

The Dwight D. Eisenhower National System of Interstate and Defense Highways: The Road to Success?

ERIC Educational Resources Information Center

Blas, Elisheva

2010-01-01

The Dwight D. Eisenhower National System of Interstate and Defense Highways was an innovation that changed America. The highway system, the greatest public works project in American history, made travel faster, easier, and safer. However, there were serious negative effects of the highways; they hindered the growth of cities, destroyed…

Defense Health Care: DOD Chiropractor Wage Rates

DTIC Science & Technology

2013-03-14

Page 2 Introduction • In 2000, Congress mandated that the Department of Defense (DOD) develop a plan to provide chiropractic care as a permanent...part of the Defense Health Program. • Prior to the establishment of DOD’s chiropractic program, Congress directed DOD to conduct demonstration...projects to evaluate the feasibility and advisability of expanding DOD’s health system to include chiropractic care. • The National Defense

Defense Agencies Initiative Increment 2 (DAI Inc 2)

DTIC Science & Technology

2016-03-01

2016 Major Automated Information System Annual Report Defense Agencies Initiative Increment 2 (DAI Inc 2) Defense Acquisition Management...Automated Information System MAIS OE - MAIS Original Estimate MAR – MAIS Annual Report MDA - Milestone Decision Authority MDD - Materiel Development...management systems supporting diverse operational functions and the warfighter in decision making and financial reporting . These disparate, non

Second Line of Defense Virtual Private Network Guidance for Deployed and New CAS Systems

DOE Office of Scientific and Technical Information (OSTI.GOV)

Singh, Surya V.; Thronas, Aaron I.

2010-01-01

This paper discusses the importance of remote access via virtual private network (VPN) for the Second Line of Defense (SLD) Central Alarm System (CAS) sites, the requirements for maintaining secure channels while using VPN and implementation requirements for current and future sites.

75 FR 20825 - Information Collection Requirement; Defense Federal Acquisition Regulation Supplement; DoD Pilot...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-21

... DEPARTMENT OF DEFENSE Defense Acquisition Regulations System [OMB Control Number 0704-0332] Information Collection Requirement; Defense Federal Acquisition Regulation Supplement; DoD Pilot Mentor-Protege Program AGENCY: Defense Acquisition Regulations System, Department of Defense (DoD). ACTION...

Modular Open System Architecture for Reducing Contamination Risk in the Space and Missile Defense Supply Chain

NASA Technical Reports Server (NTRS)

Seasly, Elaine

2015-01-01

To combat contamination of physical assets and provide reliable data to decision makers in the space and missile defense community, a modular open system architecture for creation of contamination models and standards is proposed. Predictive tools for quantifying the effects of contamination can be calibrated from NASA data of long-term orbiting assets. This data can then be extrapolated to missile defense predictive models. By utilizing a modular open system architecture, sensitive data can be de-coupled and protected while benefitting from open source data of calibrated models. This system architecture will include modules that will allow the designer to trade the effects of baseline performance against the lifecycle degradation due to contamination while modeling the lifecycle costs of alternative designs. In this way, each member of the supply chain becomes an informed and active participant in managing contamination risk early in the system lifecycle.

Role of plant β-glucosidases in the dual defense system of iridoid glycosides and their hydrolyzing enzymes in Plantago lanceolata and Plantago major.

PubMed

Pankoke, Helga; Buschmann, Torsten; Müller, Caroline

2013-10-01

The typical defense compounds of Plantaginaceae are the iridoid glycosides, which retard growth and/or enhance mortality of non-adapted herbivores. In plants, glycosidic defense compounds and hydrolytic enzymes often form a dual defense system, in which the glycosides are activated by the enzymes to exert biological effects. Yet, little is known about the activating enzymes in iridoid glycoside-containing plants. To examine the role of plant-derived β-glucosidases in the dual defense system of two common plantain species, Plantago lanceolata and Plantago major, we determined the concentration of iridoid glycosides as well as the β-glucosidase activity in leaves of different age. To investigate the presence of other leaf metabolites potentially involved in plant defense, we used a metabolic fingerprinting approach with ultra-high performance liquid chromatography coupled with time-of-flight-mass spectrometry. According to the optimal defense hypothesis, more valuable parts such as young leaves should be better protected than less valuable parts. Therefore, we expected that both, the concentrations of defense compounds as well as the β-glucosidase activity, should be highest in younger leaves and decrease with increasing leaf age. Both species possessed β-glucosidase activity, which hydrolyzed aucubin, one of the two most abundant iridoid glycosides in both plant species, with high activity. In line with the optimal defense hypothesis, the β-glucosidase activity in both Plantago species as well as the concentration of defense-related metabolites such as iridoid glycosides correlated negatively to leaf age. When leaf extracts were incubated with bovine serum albumin and aucubin, SDS-PAGE revealed a protein-denaturing effect of the leaf extracts of both plantain species, suggesting that iridoid glycosides and plant β-glucosidase interact in a dual defense system. Copyright © 2013 Elsevier Ltd. All rights reserved.

Soybean defense responses to the soybean aphid.

PubMed

Li, Yan; Zou, Jijun; Li, Min; Bilgin, Damla D; Vodkin, Lila O; Hartman, Glen L; Clough, Steven J

2008-01-01

Transcript profiles in aphid (Aphis glycines)-resistant (cv. Dowling) and -susceptible (cv. Williams 82) soybean (Glycine max) cultivars using soybean cDNA microarrays were investigated. Large-scale soybean cDNA microarrays representing approx. 18 000 genes or c. 30% of the soybean genome were compared at 6 and 12 h post-application of aphids. In a separate experiment utilizing clip cages, expression of three defense-related genes were examined at 6, 12, 24, 48, and 72 h in both cultivars by quantitative real-time PCR. One hundred and forty genes showed specific responses for resistance; these included genes related to cell wall, defense, DNA/RNA, secondary metabolism, signaling and other processes. When an extended time period of sampling was investigated, earlier and greater induction of three defense-related genes was observed in the resistant cultivar; however, the induction declined after 24 or 48 h in the resistant cultivar but continued to increase in the susceptible cultivar after 24 h. Aphid-challenged resistant plants showed rapid differential gene expression patterns similar to the incompatible response induced by avirulent Pseudomonas syringae. Five genes were identified as differentially expressed between the two genotypes in the absence of aphids.

Optimal Defense Strategies in an Idealized Microbial Food Web under Trade-Off between Competition and Defense

PubMed Central

Våge, Selina; Storesund, Julia E.; Giske, Jarl; Thingstad, T. Frede

2014-01-01

Trophic mechanisms that can generate biodiversity in food webs include bottom-up (growth rate regulating) and top-down (biomass regulating) factors. The top-down control has traditionally been analyzed using the concepts of “Keystone Predation” (KP) and “Killing-the-Winner” (KtW), predominately occuring in discussions of macro- and micro-biological ecology, respectively. Here we combine the classical diamond-shaped food web structure frequently discussed in KP analyses and the KtW concept by introducing a defense strategist capable of partial defense. A formalized description of a trade-off between the defense-strategist's competitive and defensive ability is included. The analysis reveals a complex topology of the steady state solution with strong relationships between food web structure and the combination of trade-off, defense strategy and the system's nutrient content. Among the results is a difference in defense strategies corresponding to maximum biomass, production, or net growth rate of invading individuals. The analysis thus summons awareness that biomass or production, parameters typically measured in field studies to infer success of particular biota, are not directly acted upon by natural selection. Under coexistence with a competition specialist, a balance of competitive and defensive ability of the defense strategist was found to be evolutionarily stable, whereas stronger defense was optimal under increased nutrient levels in the absence of the pure competition specialist. The findings of success of different defense strategies are discussed with respect to SAR11, a highly successful bacterial clade in the pelagic ocean. PMID:24999739

Directed Energy Technology Working Group Report (IDA/OSD R&M (Institute for Defense Analyses/Office of the Secretary of Defense Reliability and Maintainability) Study).

DTIC Science & Technology

1983-08-01

Missile (SLBM) Defense Scenario ............................................ B-1 C Space-Based Anti-Ballistic Missile ( ABM ) Defense Scenario...Ballistic Missile (SLBM) Defense Scenario, and at Strategic Space-Based Anti-Ballistic Missile ( ABM ) Defense Scenario. These case studies are provided...of flight. 3.5.3 Spaced-Based ABM Defense Scenario In this scenario, an orbiting battle station is operating as an element of GBMD System, and it is

A Framework for a Decision Support System in a Hierarchical Extended Enterprise Decision Context

NASA Astrophysics Data System (ADS)

Boza, Andrés; Ortiz, Angel; Vicens, Eduardo; Poler, Raul

Decision Support System (DSS) tools provide useful information to decision makers. In an Extended Enterprise, a new goal, changes in the current objectives or small changes in the extended enterprise configuration produce a necessary adjustment in its decision system. A DSS in this context must be flexible and agile to make suitable an easy and quickly adaptation to this new context. This paper proposes to extend the Hierarchical Production Planning (HPP) structure to an Extended Enterprise decision making context. In this way, a framework for DSS in Extended Enterprise context is defined using components of HPP. Interoperability details have been reviewed to identify the impact in this framework. The proposed framework allows overcoming some interoperability barriers, identifying and organizing components for a DSS in Extended Enterprise context, and working in the definition of an architecture to be used in the design process of a flexible DSS in Extended Enterprise context which can reuse components for futures Extended Enterprise configurations.

Soviet Assessments of North American Air Defense

DTIC Science & Technology

1986-06-01

whether they represented misunderstandings or errors on the Soviet part, or unique Soviet perspectives and biases. Finally, articles on Soviet strategy...and what reactions do these assessments prompt? First, most articles on U.S. continental air defenses were found in the journal of the Air Defense...Soviet assessments of U.S. air defense control systems with articles in Military Thought. Some of these themes are: - The importance of centralized

75 FR 40714 - Defense Federal Acquisition Regulation Supplement; Publication of Notification of Bundling of...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-13

... DEPARTMENT OF DEFENSE Defense Acquisition Regulations System 48 CFR Parts 205 and 210 Defense Federal Acquisition Regulation Supplement; Publication of Notification of Bundling of Contracts of the Department of Defense (DFARS Case 2009-D033) AGENCY: Defense Acquisition Regulations System, Department of...

75 FR 33752 - Defense Federal Acquisition Regulation Supplement; Organizational Conflicts of Interest in Major...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-15

... DEPARTMENT OF DEFENSE Defense Acquisition Regulations System 48 CFR Parts 202, 203, 212, and 252 [DFARS Case 2009-D015] RIN 0750-AG63 Defense Federal Acquisition Regulation Supplement; Organizational Conflicts of Interest in Major Defense Acquisition Programs AGENCY: Defense Acquisition Regulations System...

Manned orbital systems concepts study. Book 2: Requirements for extended-duration missions

NASA Technical Reports Server (NTRS)

1975-01-01

In order to provide essential data needed in long-range program planning, the Manned Orbital Systems Concepts (MOSC) study attempted to define, evaluate, and compare concepts for manned orbital systems that provide extended experiment mission capabilities in space, flexibility of operation, and growth potential. Specific areas discussed include roles and requirements for man in future space missions, requirements for extended capability, mission/payload concepts, and preliminary design and operational requirements.

Extended Duration Orbiter (EDO) Improved Waste Collection System (IWCS)

NASA Technical Reports Server (NTRS)

1992-01-01

This overall front view shows the Extended Duration Orbiter (EDO) Waste Collection System (WCS) scheduled to fly aboard NASA's Endeavour, Orbiter Vehicle (OV) 105, for the STS-54 mission. Detailed Test Objective 662, Extended duration orbiter WCS evaluation, will verify the design of the new EDO WCS under microgravity conditions for a prolonged period. OV-105 has been modified with additional structures in the waste management compartment (WMC) and additional avionics to support/restrain the EDO WCS. Among the advantages the new IWCS is hoped to have over the currect WCS are greater dependability, better hygiene, virtually unlimited capacity, and more efficient preparation between shuttle missions. Unlike the previous WCS, the improved version will not have to be removed from the spacecraft to be readied for the next flight. The WCS was documented in JSC's Crew Systems Laboratory Bldg 7.

Anti-CRISPR proteins: Counterattack of phages on bacterial defense (CRISPR/Cas) system.

PubMed

Chaudhary, Kulbhushan; Chattopadhyay, Anirudha; Pratap, Dharmendra

2018-01-01

Since the dawn of life there is a never ending strife between bacteria and phages. Both are perpetually changing their strategies to take over each other. CRISPR/Cas is the most widespread defense system used by bacteria against mobile genetic elements (MGEs) such as phages, cojugative palsmids, transoposons, and pathogenicity islands. This system utilizes small guide RNA molecules to protect against phages infection and invasion by MGEs. Phages circumvent to these antiviral barriers by point mutation in PAM (protospacer-adjacent motif) sequence, genome rearrangements and by using anti-CRISPR proteins. © 2017 Wiley Periodicals, Inc.

76 FR 23504 - Defense Federal Acquisition Regulation Supplement; Definition of Multiple-Award Contract (DFARS...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-27

... DEPARTMENT OF DEFENSE Defense Acquisition Regulations System 48 CFR Part 207 RIN 0750-AH12 Defense Federal Acquisition Regulation Supplement; Definition of Multiple-Award Contract (DFARS Case 2011-D016) AGENCY: Defense Acquisition Regulations System, Department of Defense (DoD). ACTION: Final rule. SUMMARY...

76 FR 32843 - Defense Federal Acquisition Regulation Supplement; Fire-Resistant Fiber for Production of...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-06

... DEPARTMENT OF DEFENSE Defense Acquisition Regulations System 48 CFR Part 225 RIN 0750-AH22 Defense Federal Acquisition Regulation Supplement; Fire-Resistant Fiber for Production of Military Uniforms (DFARS Case 2011-D021) AGENCY: Defense Acquisition Regulations System, Department of Defense (DoD). ACTION...

Protease inhibitor (PI) mediated defense in leaves and flowers of pigeonpea (protease inhibitor mediated defense in pigeonpea).

PubMed

Padul, Manohar V; Tak, Rajesh D; Kachole, Manvendra S

2012-03-01

More than 200 insect pests are found growing on pigeonpea. Insects lay eggs, attack and feed on leaves, flowers and developing pods. Plants have developed elaborate defenses against these insect pests. The present work evaluates protease inhibitor (PI) based defense of pigeonpea in leaves and flowers. PIs in the extracts of these tender tissues were detected by using gel X-ray film contact print method. Up to three PIs (PI-3, PI-4 and PI-5) were detected in these tissues as against nine (PI-1-PI-9) in mature seeds. PI-3 is the major component of these tissues. Mechanical wounding, insect chewing, fungal pathogenesis and application of salicylic acid induced PIs in pigeonpea in these tissues. Induction was found to be local as well as systemic but local response was stronger than systemic response. During both local and systemic induction, PI-3 appeared first. In spite of the presence and induction of PIs in these tender tissues and seeds farmers continue to suffer yield loses. This is due to the weak expression of PIs. However the ability of the plant to respond to external stimuli by producing defense proteins does not seem to be compromised. This study therefore indicates that PIs are components of both constitutive and inducible defense and provide a ground for designing stronger inducible defense (PIs or other insect toxin based) in pigeonpea. Copyright © 2011 Elsevier Masson SAS. All rights reserved.

Human-machine analytics for closed-loop sense-making in time-dominant cyber defense problems

NASA Astrophysics Data System (ADS)

Henry, Matthew H.

2017-05-01

Many defense problems are time-dominant: attacks progress at speeds that outpace human-centric systems designed for monitoring and response. Despite this shortcoming, these well-honed and ostensibly reliable systems pervade most domains, including cyberspace. The argument that often prevails when considering the automation of defense is that while technological systems are suitable for simple, well-defined tasks, only humans possess sufficiently nuanced understanding of problems to act appropriately under complicated circumstances. While this perspective is founded in verifiable truths, it does not account for a middle ground in which human-managed technological capabilities extend well into the territory of complex reasoning, thereby automating more nuanced sense-making and dramatically increasing the speed at which it can be applied. Snort1 and platforms like it enable humans to build, refine, and deploy sense-making tools for network defense. Shortcomings of these platforms include a reliance on rule-based logic, which confounds analyst knowledge of how bad actors behave with the means by which bad behaviors can be detected, and a lack of feedback-informed automation of sensor deployment. We propose an approach in which human-specified computational models hypothesize bad behaviors independent of indicators and then allocate sensors to estimate and forecast the state of an intrusion. State estimates and forecasts inform the proactive deployment of additional sensors and detection logic, thereby closing the sense-making loop. All the while, humans are on the loop, rather than in it, permitting nuanced management of fast-acting automated measurement, detection, and inference engines. This paper motivates and conceptualizes analytics to facilitate this human-machine partnership.

77 FR 76938 - Defense Federal Acquisition Regulation Supplement: Contracting Activity Updates (DFARS Case 2012...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-31

... DEPARTMENT OF DEFENSE Defense Acquisition Regulations System 48 CFR Part 202 RIN 0750-AH81 Defense...: Defense Acquisition Regulations System, Department of Defense (DoD). ACTION: Final rule. SUMMARY: DoD is... has either a significant effect beyond the internal operating procedures of the agency issuing the...

Comparison of Intracellular "Ca. Endomicrobium Trichonymphae" Genomovars Illuminates the Requirement and Decay of Defense Systems against Foreign DNA.

PubMed

Izawa, Kazuki; Kuwahara, Hirokazu; Kihara, Kumiko; Yuki, Masahiro; Lo, Nathan; Itoh, Takehiko; Ohkuma, Moriya; Hongoh, Yuichi

2016-10-13

"Candidatus Endomicrobium trichonymphae" (Bacteria; Elusimicrobia) is an obligate intracellular symbiont of the cellulolytic protist genus Trichonympha in the termite gut. A previous genome analysis of "Ca Endomicrobium trichonymphae" phylotype Rs-D17 (genomovar Ri2008), obtained from a Trichonympha agilis cell in the gut of the termite Reticulitermes speratus, revealed that its genome is small (1.1 Mb) and contains many pseudogenes; it is in the course of reductive genome evolution. Here we report the complete genome sequence of another Rs-D17 genomovar, Ti2015, obtained from a different T. agilis cell present in an R. speratus gut. These two genomovars share most intact protein-coding genes and pseudogenes, showing 98.6% chromosome sequence similarity. However, characteristic differences were found in their defense systems, which comprised restriction-modification and CRISPR/Cas systems. The repertoire of intact restriction-modification systems differed between the genomovars, and two of the three CRISPR/Cas loci in genomovar Ri2008 are pseudogenized or missing in genomovar Ti2015. These results suggest relaxed selection pressure for maintaining these defense systems. Nevertheless, the remaining CRISPR/Cas system in each genomovar appears to be active; none of the "spacer" sequences (112 in Ri2008 and 128 in Ti2015) were shared whereas the "repeat" sequences were identical. Furthermore, we obtained draft genomes of three additional endosymbiotic Endomicrobium phylotypes from different host protist species, and discovered multiple, intact CRISPR/Cas systems in each genome. Collectively, unlike bacteriome endosymbionts in insects, the Endomicrobium endosymbionts of termite-gut protists appear to require defense against foreign DNA, although the required level of defense has likely been reduced during their intracellular lives. © The Author 2016. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.

75 FR 59102 - Defense Federal Acquisition Regulation Supplement; Part 204, Administrative Matters

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-27

... indexing methodology across DoD. This technical amendment adds language to the Defense Federal Acquisition... DEPARTMENT OF DEFENSE Defense Acquisition Regulations System 48 CFR Part 204 Defense Federal Acquisition Regulation Supplement; Part 204, Administrative Matters AGENCY: Defense Acquisition Regulations...

78 FR 63462 - Information Collection Requirement; Defense Federal Acquisition Regulation Supplement...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-10-24

... DEPARTMENT OF DEFENSE Defense Acquisition Regulations System [Docket Number DARS-2013-0035] Information Collection Requirement; Defense Federal Acquisition Regulation Supplement; Organizational Conflict..., Department of Defense (DoD). ACTION: Notice and request for comments regarding a proposed extension of an...

76 FR 52139 - Defense Federal Acquisition Regulation Supplement; Government; Property (DFARS Case 2009-D008)

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-19

... DEPARTMENT OF DEFENSE Defense Acquisition Regulations System 48 CFR Parts 201, 245, and 252 RIN...-D008) AGENCY: Defense Acquisition Regulations System, Department of Defense (DoD). ACTION: Final rule... Department of Defense as ineligible, debarred, or suspended from defense contracts; or (iv) Subject to denial...

Improving the Defense Acquisition System and Reducing System Costs

DTIC Science & Technology

1981-03-30

The need for this specific commitment results from the competition among the conflicting objectives of high perform- ance, lower cost, shorter... conflict with initiatives to improve reliability and support. Whereas the fastest acquisition approach involves initiating production prxor to...their Individual thrusts result in confusion on the part of OASD who tries to implement conflicting programs, and of defense contractors performing

The Sinorhizobium (Ensifer) fredii HH103 Type 3 Secretion System Suppresses Early Defense Responses to Effectively Nodulate Soybean.

PubMed

Jiménez-Guerrero, Irene; Pérez-Montaño, Francisco; Monreal, José Antonio; Preston, Gail M; Fones, Helen; Vioque, Blanca; Ollero, Francisco Javier; López-Baena, Francisco Javier

2015-07-01

Plants that interact with pathogenic bacteria in their natural environments have developed barriers to block or contain the infection. Phytopathogenic bacteria have evolved mechanisms to subvert these defenses and promote infection. Thus, the type 3 secretion system (T3SS) delivers bacterial effectors directly into the plant cells to alter host signaling and suppress defenses, providing an appropriate environment for bacterial multiplication. Some rhizobial strains possess a symbiotic T3SS that seems to be involved in the suppression of host defenses to promote nodulation and determine the host range. In this work, we show that the inactivation of the Sinorhizobium (Ensifer) fredii HH103 T3SS negatively affects soybean nodulation in the early stages of the symbiotic process, which is associated with a reduction of the expression of early nodulation genes. This symbiotic phenotype could be the consequence of the bacterial triggering of soybean defense responses associated with the production of salicylic acid (SA) and the impairment of the T3SS mutant to suppress these responses. Interestingly, the early induction of the transcription of GmMPK4, which negatively regulates SA accumulation and defense responses in soybean via WRKY33, could be associated with the differential defense responses induced by the parental and the T3SS mutant strain.

75 FR 25165 - Defense Federal Acquisition Regulation Supplement; Cost and Software Data Reporting System

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-07

... 215, 234, 242, and 252 Defense Federal Acquisition Regulation Supplement; Cost and Software Data... Regulation Supplement (DFARS) to set forth DoD Cost and Software Data Reporting system requirements for major... set forth the DoD requirement for offerors to: Describe the standard Cost and Software Data Reporting...

Confinement of Radioactive Materials at Defense Nuclear Facilities

DTIC Science & Technology

2004-10-01

The design of defense nuclear facilities includes systems whose reliable operation is vital to the protection of the public, workers, and the...final safety-class barrier to the release of hazardous materials with potentially serious public consequences. The Defense Nuclear Facilities Safety...the public at certain defense nuclear facilities . This change has resulted in downgrading of the functional safety classification of confinement

Extended Duration Orbiter (EDO) Improved Waste Collection System (IWCS)

NASA Technical Reports Server (NTRS)

1992-01-01

This high angle overall view shows the top side components of the Extended Duration Orbiter (EDO) Waste Collection System (WCS) scheduled to fly aboard NASA's Endeavour, Orbiter Vehicle (OV) 105, for the STS-54 mission. Detailed Test Objective 662, Extended duration orbiter WCS evaluation, will verify the design of the new EDO WCS under microgravity conditions for a prolonged period. OV-105 has been modified with additional structures in the waste management compartment (WMC) and additional avionics to support/restrain the EDO WCS. Among the advantages the new IWCS is hoped to have over the currect WCS are greater dependability, better hygiene, virtually unlimited capacity, and more efficient preparation between shuttle missions. Unlike the previous WCS, the improved version will not have to be removed from the spacecraft to be readied for the next flight. The WCS was documented in JSC's Crew Systems Laboratory Bldg 7.

Extending self-organizing particle systems to problem solving.

PubMed

Rodríguez, Alejandro; Reggia, James A

2004-01-01

Self-organizing particle systems consist of numerous autonomous, purely reflexive agents ("particles") whose collective movements through space are determined primarily by local influences they exert upon one another. Inspired by biological phenomena (bird flocking, fish schooling, etc.), particle systems have been used not only for biological modeling, but also increasingly for applications requiring the simulation of collective movements such as computer-generated animation. In this research, we take some first steps in extending particle systems so that they not only move collectively, but also solve simple problems. This is done by giving the individual particles (agents) a rudimentary intelligence in the form of a very limited memory and a top-down, goal-directed control mechanism that, triggered by appropriate conditions, switches them between different behavioral states and thus different movement dynamics. Such enhanced particle systems are shown to be able to function effectively in performing simulated search-and-collect tasks. Further, computational experiments show that collectively moving agent teams are more effective than similar but independently moving ones in carrying out such tasks, and that agent teams of either type that split off members of the collective to protect previously acquired resources are most effective. This work shows that the reflexive agents of contemporary particle systems can readily be extended to support goal-directed problem solving while retaining their collective movement behaviors. These results may prove useful not only for future modeling of animal behavior, but also in computer animation, coordinated movement control in robotic teams, particle swarm optimization, and computer games.

Coevolutionary arms race versus host defense chase in a tropical herbivore-plant system.

PubMed

Endara, María-José; Coley, Phyllis D; Ghabash, Gabrielle; Nicholls, James A; Dexter, Kyle G; Donoso, David A; Stone, Graham N; Pennington, R Toby; Kursar, Thomas A

2017-09-05

Coevolutionary models suggest that herbivores drive diversification and community composition in plants. For herbivores, many questions remain regarding how plant defenses shape host choice and community structure. We addressed these questions using the tree genus Inga and its lepidopteran herbivores in the Amazon. We constructed phylogenies for both plants and insects and quantified host associations and plant defenses. We found that similarity in herbivore assemblages between Inga species was correlated with similarity in defenses. There was no correlation with phylogeny, a result consistent with our observations that the expression of defenses in Inga is independent of phylogeny. Furthermore, host defensive traits explained 40% of herbivore community similarity. Analyses at finer taxonomic scales showed that different lepidopteran clades select hosts based on different defenses, suggesting taxon-specific histories of herbivore-host plant interactions. Finally, we compared the phylogeny and defenses of Inga to phylogenies for the major lepidopteran clades. We found that closely related herbivores fed on Inga with similar defenses rather than on closely related plants. Together, these results suggest that plant defenses might be more evolutionarily labile than the herbivore traits related to host association. Hence, there is an apparent asymmetry in the evolutionary interactions between Inga and its herbivores. Although plants may evolve under selection by herbivores, we hypothesize that herbivores may not show coevolutionary adaptations, but instead "chase" hosts based on the herbivore's own traits at the time that they encounter a new host, a pattern more consistent with resource tracking than with the arms race model of coevolution.

Coevolutionary arms race versus host defense chase in a tropical herbivore–plant system

PubMed Central

Coley, Phyllis D.; Ghabash, Gabrielle; Nicholls, James A.; Donoso, David A.; Stone, Graham N.; Pennington, R. Toby; Kursar, Thomas A.

2017-01-01

Coevolutionary models suggest that herbivores drive diversification and community composition in plants. For herbivores, many questions remain regarding how plant defenses shape host choice and community structure. We addressed these questions using the tree genus Inga and its lepidopteran herbivores in the Amazon. We constructed phylogenies for both plants and insects and quantified host associations and plant defenses. We found that similarity in herbivore assemblages between Inga species was correlated with similarity in defenses. There was no correlation with phylogeny, a result consistent with our observations that the expression of defenses in Inga is independent of phylogeny. Furthermore, host defensive traits explained 40% of herbivore community similarity. Analyses at finer taxonomic scales showed that different lepidopteran clades select hosts based on different defenses, suggesting taxon-specific histories of herbivore–host plant interactions. Finally, we compared the phylogeny and defenses of Inga to phylogenies for the major lepidopteran clades. We found that closely related herbivores fed on Inga with similar defenses rather than on closely related plants. Together, these results suggest that plant defenses might be more evolutionarily labile than the herbivore traits related to host association. Hence, there is an apparent asymmetry in the evolutionary interactions between Inga and its herbivores. Although plants may evolve under selection by herbivores, we hypothesize that herbivores may not show coevolutionary adaptations, but instead “chase” hosts based on the herbivore’s own traits at the time that they encounter a new host, a pattern more consistent with resource tracking than with the arms race model of coevolution. PMID:28827317

Extending NASA's SPICE ancillary information system to meet future mission needs

NASA Technical Reports Server (NTRS)

Acton, C.; Bachman, N.; Elson, L.; Semenov, B.; Turner, F.; Wright, E.

2002-01-01

This paper summarizes the architecture, capabilities, characteristics and uses of the current SPICE ancillary information system, and then outlines plans and ideas for how this system can be extended to meet future space mission requirements.

A Systems Approach to Finding Cost-Effective Alternatives to European Ballistic Missile Defense

DTIC Science & Technology

2013-09-01

has holes in its ability to cover the entire region as required. What are the existing approaches to ballistic missile defense in Europe? 4. What Are...however, this report focuses on ballistic missiles which use stellar or inertial guidance systems which are not subject to electromagnetic...location as the Baseline system (35.6° N, 32.5° E) while the other was placed north of Turkey in the Black Sea (41.5° N, 38.1° E). Each Aegis ship was

Total Quality Management in the Department of Defense

DTIC Science & Technology

1989-09-01

DTI ELECT SDu TOTAL QUALITY MANAGEMENT IN THE DEPARTMENT OF DEFENSE THESIS BRUCE E. SPRINGS, B.S. CAPTAIN, USAF AFIT/GLN/LSR/ 89S -57 I1- DEPARTMENT...13 0 3 AFIT/GLM/LSR/89S-57 TOTAL QUALITY MANAGEMENT IN THE DEPARTMENT OF DEFENSE THESIS BRUCE E. SPRINGS, B.S. CAPTAIN, USAF AFIT/GLH/LSR/89S-57...Defense. # AFIT/GLM/LSR/89S-57 TOTAL QUALITY MANAGEMENT IN THE DEPARTMENT OF DEFENSE THESIS Presented to the Faculty of the School of Systems and Logistics

Effects of Gain/Loss Framing in Cyber Defense Decision-Making

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bos, Nathan; Paul, Celeste; Gersh, John

Cyber defense requires decision making under uncertainty. Yet this critical area has not been a strong focus of research in judgment and decision-making. Future defense systems, which will rely on software-defined networks and may employ ‘moving target’ defenses, will increasingly automate lower level detection and analysis, but will still require humans in the loop for higher level judgment. We studied the decision making process and outcomes of 17 experienced network defense professionals who worked through a set of realistic network defense scenarios. We manipulated gain versus loss framing in a cyber defense scenario, and found significant effects in one ofmore » two focal problems. Defenders that began with a network already in quarantine (gain framing) used a quarantine system more than those that did not (loss framing). We also found some difference in perceived workload and efficacy. Alternate explanations of these findings and implications for network defense are discussed.« less

Defense Science Board Task Force Report on Cyber Defense Management

DTIC Science & Technology

2016-09-01

manage cyber security is often a verymanual and labor intensive process. When a crisis hits, DoD responses range from highly automatedand instrumented...DSB Task Force Report on Cyber Defense Management September 2016 (U) This page intentionally blank REPORT OF THE DEFENSE SCIENCE BOARD STUDY ON Cyber ...DEFENSE FOR ACQUISITION, TECHNOLOGY & LOGISTICS SUBJECT: Final Report of the Defense Science Board (DSB) Task Force on Cyber Defense Management I am

Plant innate immunity: an updated insight into defense mechanism.

PubMed

Muthamilarasan, Mehanathan; Prasad, Manoj

2013-06-01

Plants are invaded by an array of pathogens of which only a few succeed in causing disease. The attack by others is countered by a sophisticated immune system possessed by the plants. The plant immune system is broadly divided into two, viz. microbial-associated molecular-patterns-triggered immunity (MTI) and effector-triggered immunity (ETI). MTI confers basal resistance, while ETI confers durable resistance, often resulting in hypersensitive response. Plants also possess systemic acquired resistance (SAR), which provides long-term defense against a broad-spectrum of pathogens. Salicylic-acid-mediated systemic acquired immunity provokes the defense response throughout the plant system during pathogen infection at a particular site. Trans-generational immune priming allows the plant to heritably shield their progeny towards pathogens previously encountered. Plants circumvent the viral infection through RNA interference phenomena by utilizing small RNAs. This review summarizes the molecular mechanisms of plant immune system, and the latest breakthroughs reported in plant defense. We discuss the plant–pathogen interactions and integrated defense responses in the context of presenting an integral understanding in plant molecular immunity.

Extending TOPS: Ontology-driven Anomaly Detection and Analysis System

NASA Astrophysics Data System (ADS)

Votava, P.; Nemani, R. R.; Michaelis, A.

2010-12-01

Terrestrial Observation and Prediction System (TOPS) is a flexible modeling software system that integrates ecosystem models with frequent satellite and surface weather observations to produce ecosystem nowcasts (assessments of current conditions) and forecasts useful in natural resources management, public health and disaster management. We have been extending the Terrestrial Observation and Prediction System (TOPS) to include a capability for automated anomaly detection and analysis of both on-line (streaming) and off-line data. In order to best capture the knowledge about data hierarchies, Earth science models and implied dependencies between anomalies and occurrences of observable events such as urbanization, deforestation, or fires, we have developed an ontology to serve as a knowledge base. We can query the knowledge base and answer questions about dataset compatibilities, similarities and dependencies so that we can, for example, automatically analyze similar datasets in order to verify a given anomaly occurrence in multiple data sources. We are further extending the system to go beyond anomaly detection towards reasoning about possible causes of anomalies that are also encoded in the knowledge base as either learned or implied knowledge. This enables us to scale up the analysis by eliminating a large number of anomalies early on during the processing by either failure to verify them from other sources, or matching them directly with other observable events without having to perform an extensive and time-consuming exploration and analysis. The knowledge is captured using OWL ontology language, where connections are defined in a schema that is later extended by including specific instances of datasets and models. The information is stored using Sesame server and is accessible through both Java API and web services using SeRQL and SPARQL query languages. Inference is provided using OWLIM component integrated with Sesame.

Department of Defense high power laser program guidance

NASA Astrophysics Data System (ADS)

Muller, Clifford H.

1994-06-01

The DoD investment of nominally $200 million per year is focused on four high power laser (HPL) concepts: Space-Based Laser (SBL), a Ballistic Missile Defense Organization effort that addresses boost-phase intercept for Theater Missile Defense and National Missile Defense; Airborne Laser (ABL), an Air Force effort that addresses boost-phase intercept for Theater Missile Defense; Ground-Based Laser (GBL), an Air Force effort addressing space control; and Anti-Ship Missile Defense (ASMD), a Navy effort addressing ship-based defense. Each organization is also supporting technology development with the goal of achieving less expensive, brighter, and lighter high power laser systems. These activities represent the building blocks of the DoD program to exploit the compelling characteristics of the high power laser. Even though DoD's HPL program are focused and moderately strong, additional emphasis in a few technical areas could help reduce risk in these programs. In addition, a number of options are available for continuing to use the High-Energy Laser System Test Facility (HELSTF) at White Sands Missile Range. This report provides a brief overview and guidance for the five efforts which comprise the DoD HPL program (SBL, ABL, GBL, ASMD, HELSTF).

Multi-Objective Optimization of System Capability Satisficing in Defense Acquisition

DTIC Science & Technology

2012-04-30

sponsored by the USD(AT&L). Second, we issue an annual internal call for proposals to seek NPS faculty research supporting the interests of our...program sponsors. Finally, we serve as a “broker” to market specific research topics identified by our sponsors to NPS graduate students. This three...expanding the technology readiness level within defense acquisition. International Journal of Defense Acquisition Management, 1, 39–58. Tan, W

DELFIC: Department of Defense Fallout Prediction System. Volume I - Fundamentals

DTIC Science & Technology

1979-12-31

102 H2590D. DTIC•;. 17.) 1 i{1•ELECT ’ Prepared for " JAUG 2 ? 1980 Director DEFENSE NUCLEAR AGENCY B Wai’hington, D. C. 20305 808 1O8x Destroy this...2 1. INTRODUCTION AND OVERVIEW -- --- - -------------- - --- ---- 7 2. INITIALIZATION AND CLOUD RISE...61 6 1. INTRODUCTION AND OVERVIEW DELFIC (DEfense Land Fallout Interpretative Code) is intended for re- search in local nuclear fallout

76 FR 8303 - Defense Federal Acquisition Regulation Supplement; Award-Fee Contracts (DFARS Case 2006-D021)

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-14

... DEPARTMENT OF DEFENSE Defense Acquisition Regulations System 48 CFR Parts 216 and 252 RIN 0750...) AGENCY: Defense Acquisition Regulations System, Department of Defense (DoD). ACTION: Final rule. SUMMARY... Regulations System, OUSD (AT&L) DPAP/DARS, 3060 Defense Pentagon, Room 3B855, Washington, DC 20301-3060...

Ground-Based Missile Defense (National Missile Defense): Is It Feasible?

DTIC Science & Technology

2004-03-19

Westview Press), 191. 47 Ibid. 192. 48 Dr. Nicholas Berry, National Missile Defense: What Does It All Mean ? National Missile Defense: Views from Asia...153. 18 19 BIBLIOGRAPHY Berry, Nicholas. National Missile Defense: What Does It All Mean ? National Missile Defense: Views from Asia, Center for

77 FR 2653 - Defense Federal Acquisition Regulation Supplement; Pilot Program for Acquisition of Military...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-01-19

... DEPARTMENT OF DEFENSE Defense Acquisition Regulations System 48 CFR Parts 212 and 252 RIN 0750-AH27 Defense Federal Acquisition Regulation Supplement; Pilot Program for Acquisition of Military-Purpose Nondevelopmental Items (DFARS Case 2011-D034) AGENCY: Defense Acquisition Regulations System...

Good neighbors make good defenses: associational refuges reduce defense investment in African savanna plants.

PubMed

Coverdale, Tyler C; Goheen, Jacob R; Palmer, Todd M; Pringle, Robert M

2018-06-25

Intraspecific variation in plant defense phenotype is common and has wide-ranging ecological consequences. Yet prevailing theories of plant defense allocation, which primarily account for interspecific differences in defense phenotype, often fail to predict intraspecific patterns. Furthermore, although individual variation in defense phenotype is often attributed to ecological interactions, few general mechanisms have been proposed to explain the ubiquity of variable defense phenotype within species. Here, we show experimentally that associational refuges and induced resistance interact to create predictable intraspecific variation in defense phenotype in African savanna plants. Physically defended species from four families (Acanthaceae, Asparagaceae, Cactaceae, and Solanaceae) growing in close association with spinescent Acacia trees had 39-78% fewer spines and thorns than did isolated conspecifics. For a subset of these species, we used a series of manipulative experiments to show that this variability is maintained primarily by a reduction in induced responses among individuals that seldom experience mammalian herbivory, whether due to association with Acacia trees or to experimental herbivore exclusion. Unassociated plants incurred 4- to 16-fold more browsing damage than did associated individuals and increased spine density by 16-38% within one month following simulated browsing. In contrast, experimental clipping induced no net change in spine density among plants growing beneath Acacia canopies or inside long-term herbivore exclosures. Associated and unassociated individuals produced similar numbers of flowers and seeds, but seedling recruitment and survival were vastly greater in refuge habitats, suggesting a net fitness benefit of association. We conclude that plant-plant associations consistently decrease defense investment in this system by reducing both the frequency of herbivory and the intensity of induced responses, and that inducible responses

Assistant Secretary of Defense for Homeland Defense and Global Security

Science.gov Websites

Defense for Policy ASD for Asian and Pacific Security Affairs ASD for Homeland Defense Global Security Special Operations/Low-Intensity Conflict Counternarcotics and Global Threats Stability and Humanitarian HomeOUSDP OfficesASD for Homeland Defense Global Security Assistant Secretary of Defense for Homeland

76 FR 13297 - Defense Federal Acquisition Regulation Supplement; Technical Amendments

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-11

... 215 Government procurement. Ynette R. Shelkin, Editor, Defense Acquisition Regulations System... Director, Defense Procurement and Acquisition Policy. DATES: Effective Date: March 11, 2011. Applicability... adding a section at 215.300 with a reference to Director, Defense Procurement and Acquisition Policy...

75 FR 75444 - Defense Federal Acquisition Regulation Supplement; Government Property (DFARS Case 2009-D008)

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-03

... DEPARTMENT OF DEFENSE Defense Acquisition Regulations System 48 CFR Parts 201, 245, and 252 RIN...-D008) AGENCY: Defense Acquisition Regulations System, Department of Defense (DoD). ACTION: Proposed... demilitarization shall be demilitarized by the Purchaser under the supervision of qualified Department of Defense...

78 FR 19467 - Information Collection Requirement; Defense Federal Acquisition Regulation Supplement (DFARS...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-01

... DEPARTMENT OF DEFENSE Defense Acquisition Regulations System [Docket Number DARS-2013-0010... Mentor-Prot[eacute]g[eacute] Program AGENCY: Defense Acquisition Regulations System, Department of... Collection DFARS Appendix I-112.2(a)-(d) requires mentor firms to report on the progress made under active...

Stable time filtering of strongly unstable spatially extended systems

PubMed Central

Grote, Marcus J.; Majda, Andrew J.

2006-01-01

Many contemporary problems in science involve making predictions based on partial observation of extremely complicated spatially extended systems with many degrees of freedom and with physical instabilities on both large and small scale. Various new ensemble filtering strategies have been developed recently for these applications, and new mathematical issues arise. Because ensembles are extremely expensive to generate, one such issue is whether it is possible under appropriate circumstances to take long time steps in an explicit difference scheme and violate the classical Courant–Friedrichs–Lewy (CFL)-stability condition yet obtain stable accurate filtering by using the observations. These issues are explored here both through elementary mathematical theory, which provides simple guidelines, and the detailed study of a prototype model. The prototype model involves an unstable finite difference scheme for a convection–diffusion equation, and it is demonstrated below that appropriate observations can result in stable accurate filtering of this strongly unstable spatially extended system. PMID:16682626

Stable time filtering of strongly unstable spatially extended systems.

PubMed

Grote, Marcus J; Majda, Andrew J

2006-05-16

Many contemporary problems in science involve making predictions based on partial observation of extremely complicated spatially extended systems with many degrees of freedom and with physical instabilities on both large and small scale. Various new ensemble filtering strategies have been developed recently for these applications, and new mathematical issues arise. Because ensembles are extremely expensive to generate, one such issue is whether it is possible under appropriate circumstances to take long time steps in an explicit difference scheme and violate the classical Courant-Friedrichs-Lewy (CFL)-stability condition yet obtain stable accurate filtering by using the observations. These issues are explored here both through elementary mathematical theory, which provides simple guidelines, and the detailed study of a prototype model. The prototype model involves an unstable finite difference scheme for a convection-diffusion equation, and it is demonstrated below that appropriate observations can result in stable accurate filtering of this strongly unstable spatially extended system.

Extended physics as a theoretical framework for systems biology?

PubMed

Miquel, Paul-Antoine

2011-08-01

In this essay we examine whether a theoretical and conceptual framework for systems biology could be built from the Bailly and Longo (2008, 2009) proposal. These authors aim to understand life as a coherent critical structure, and propose to develop an extended physical approach of evolution, as a diffusion of biomass in a space of complexity. Their attempt leads to a simple mathematical reconstruction of Gould's assumption (1989) concerning the bacterial world as a "left wall of least complexity" that we will examine. Extended physical systems are characterized by their constructive properties. Time is acting and new properties emerge by their history that can open the list of their initial properties. This conceptual and theoretical framework is nothing more than a philosophical assumption, but as such it provides a new and exciting approach concerning the evolution of life, and the transition between physics and biology. Copyright © 2011 Elsevier Ltd. All rights reserved.

76 FR 6006 - Defense Federal Acquisition Regulation Supplement; Reporting of Government Property Lost, Stolen...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-02

... DEPARTMENT OF DEFENSE Defense Acquisition Regulations System 48 CFR Parts 245 and 252 [DFARS Case 2008-D049] RIN 0750-AG64 Defense Federal Acquisition Regulation Supplement; Reporting of Government Property Lost, Stolen, Damaged, or Destroyed AGENCY: Defense Acquisition Regulations System; Department of...

Type III secretion system effector proteins: double agents in bacterial disease and plant defense.

PubMed

Alfano, James R; Collmer, Alan

2004-01-01

Many phytopathogenic bacteria inject virulence effector proteins into plant cells via a Hrp type III secretion system (TTSS). Without the TTSS, these pathogens cannot defeat basal defenses, grow in plants, produce disease lesions in hosts, or elicit the hypersensitive response (HR) in nonhosts. Pathogen genome projects employing bioinformatic methods to identify TTSS Hrp regulon promoters and TTSS pathway targeting signals suggest that phytopathogenic Pseudomonas, Xanthomonas, and Ralstonia spp. harbor large arsenals of effectors. The Hrp TTSS employs customized cytoplasmic chaperones, conserved export components in the bacterial envelope (also used by the TTSS of animal pathogens), and a more specialized set of TTSS-secreted proteins to deliver effectors across the plant cell wall and plasma membrane. Many effectors can act as molecular double agents that betray the pathogen to plant defenses in some interactions and suppress host defenses in others. Investigations of the functions of effectors within plant cells have demonstrated the plasma membrane and nucleus as subcellular sites for several effectors, revealed some effectors to possess cysteine protease or protein tyrosine phosphatase activity, and provided new clues to the coevolution of bacterium-plant interactions.

The science, technology, and politics of ballistic missile defense

DOE Office of Scientific and Technical Information (OSTI.GOV)

Coyle, Philip E.

America's missile defense systems are deployed at home and abroad. This includes the Groundbased Missile Defense (GMD) system in Alaska and California, the Phased Adaptive Approach in Europe (EPAA), and regional systems in the Middle East and Asia. Unfortunately these systems lack workable architectures, and many of the required elements either don't work or are missing. Major review and reconsideration is needed of all elements of these systems. GMD performance in tests has gotten worse with time, when it ought to be getting better. A lack of political support is not to blame as the DoD spends about $10 billionmore » per year, and proposes to add about $5 billion over the next five years. Russia objects to the EPAA as a threat to its ICBM forces, and to the extensive deployment of U.S. military forces in countries such as Poland, the Czech Republic and Romania, once part of the Soviet Union. Going forward the U.S. should keep working with Russia whose cooperation will be key to diplomatic gains in the Middle East and elsewhere. Meanwhile, America's missile defenses face an enduring set of issues, especially target discrimination in the face of attacks designed to overwhelm the defenses, stage separation debris, chaff, decoys, and stealth. Dealing with target discrimination while also replacing, upgrading, or adding to the many elements of U.S. missiles defenses presents daunting budget priorities. A new look at the threat is warranted, and whether the U.S. needs to consider every nation that possesses even short-range missiles a threat to America. The proliferation of missiles of all sizes around the world is a growing problem, but expecting U.S. missile defenses to deal with all those missiles everywhere is unrealistic, and U.S. missile defenses, effective or not, are justifying more and more offensive missiles.« less

The science, technology, and politics of ballistic missile defense

NASA Astrophysics Data System (ADS)

Coyle, Philip E.

2014-05-01

America's missile defense systems are deployed at home and abroad. This includes the Groundbased Missile Defense (GMD) system in Alaska and California, the Phased Adaptive Approach in Europe (EPAA), and regional systems in the Middle East and Asia. Unfortunately these systems lack workable architectures, and many of the required elements either don't work or are missing. Major review and reconsideration is needed of all elements of these systems. GMD performance in tests has gotten worse with time, when it ought to be getting better. A lack of political support is not to blame as the DoD spends about 10 billion per year, and proposes to add about 5 billion over the next five years. Russia objects to the EPAA as a threat to its ICBM forces, and to the extensive deployment of U.S. military forces in countries such as Poland, the Czech Republic and Romania, once part of the Soviet Union. Going forward the U.S. should keep working with Russia whose cooperation will be key to diplomatic gains in the Middle East and elsewhere. Meanwhile, America's missile defenses face an enduring set of issues, especially target discrimination in the face of attacks designed to overwhelm the defenses, stage separation debris, chaff, decoys, and stealth. Dealing with target discrimination while also replacing, upgrading, or adding to the many elements of U.S. missiles defenses presents daunting budget priorities. A new look at the threat is warranted, and whether the U.S. needs to consider every nation that possesses even short-range missiles a threat to America. The proliferation of missiles of all sizes around the world is a growing problem, but expecting U.S. missile defenses to deal with all those missiles everywhere is unrealistic, and U.S. missile defenses, effective or not, are justifying more and more offensive missiles.

Koopmans-Compliant Spectral Functionals for Extended Systems

NASA Astrophysics Data System (ADS)

Nguyen, Ngoc Linh; Colonna, Nicola; Ferretti, Andrea; Marzari, Nicola

2018-04-01

Koopmans-compliant functionals have been shown to provide accurate spectral properties for molecular systems; this accuracy is driven by the generalized linearization condition imposed on each charged excitation, i.e., on changing the occupation of any orbital in the system, while accounting for screening and relaxation from all other electrons. In this work, we discuss the theoretical formulation and the practical implementation of this formalism to the case of extended systems, where a third condition, the localization of Koopmans's orbitals, proves crucial to reach seamlessly the thermodynamic limit. We illustrate the formalism by first studying one-dimensional molecular systems of increasing length. Then, we consider the band gaps of 30 paradigmatic solid-state test cases, for which accurate experimental and computational results are available. The results are found to be comparable with the state of the art in many-body perturbation theory, notably using just a functional formulation for spectral properties and the generalized-gradient approximation for the exchange and correlation functional.

Quantum cascade lasers for defense and security

NASA Astrophysics Data System (ADS)

Day, Timothy; Pushkarsky, Michael; Caffey, Dave; Cecchetti, Kristen; Arp, Ron; Whitmore, Alex; Henson, Michael; Takeuchi, Eric B.

2013-10-01

Quantum cascade laser (QCL) systems are mature and at the vanguard of a new generation of products that support military applications such as Infrared Countermeasures (IRCM) and targeting. The demanding product requirements for aircraft platforms that include reduced size, weight, power consumption and cost (SWaP-C) extends to portable, battery powered handheld products. QCL technology operates throughout the mid-wave (MWIR) and long-wave (LWIR) infrared to provide new capabilities that leverage existing thermal imaging cameras. In addition to their suitability for aircraft platforms, QCL products are a natural fit to meet operator demands for small, lightweight pointer and beacon capabilities. Field-testing of high power, lightweight, battery operated devices has demonstrated their utility across a range of air and ground applications. This talk will present an overview of QCL technology and the Defense and Security products and capabilities that are enabled by it. This talk will also provide an overview of the extensive environmental and performance testing associated with products based on QCL technology.

Defense Strategies for Asymmetric Networked Systems with Discrete Components.

PubMed

Rao, Nageswara S V; Ma, Chris Y T; Hausken, Kjell; He, Fei; Yau, David K Y; Zhuang, Jun

2018-05-03

We consider infrastructures consisting of a network of systems, each composed of discrete components. The network provides the vital connectivity between the systems and hence plays a critical, asymmetric role in the infrastructure operations. The individual components of the systems can be attacked by cyber and physical means and can be appropriately reinforced to withstand these attacks. We formulate the problem of ensuring the infrastructure performance as a game between an attacker and a provider, who choose the numbers of the components of the systems and network to attack and reinforce, respectively. The costs and benefits of attacks and reinforcements are characterized using the sum-form, product-form and composite utility functions, each composed of a survival probability term and a component cost term. We present a two-level characterization of the correlations within the infrastructure: (i) the aggregate failure correlation function specifies the infrastructure failure probability given the failure of an individual system or network, and (ii) the survival probabilities of the systems and network satisfy first-order differential conditions that capture the component-level correlations using multiplier functions. We derive Nash equilibrium conditions that provide expressions for individual system survival probabilities and also the expected infrastructure capacity specified by the total number of operational components. We apply these results to derive and analyze defense strategies for distributed cloud computing infrastructures using cyber-physical models.

Defense Strategies for Asymmetric Networked Systems with Discrete Components

PubMed Central

Rao, Nageswara S. V.; Ma, Chris Y. T.; Hausken, Kjell; He, Fei; Yau, David K. Y.

2018-01-01

We consider infrastructures consisting of a network of systems, each composed of discrete components. The network provides the vital connectivity between the systems and hence plays a critical, asymmetric role in the infrastructure operations. The individual components of the systems can be attacked by cyber and physical means and can be appropriately reinforced to withstand these attacks. We formulate the problem of ensuring the infrastructure performance as a game between an attacker and a provider, who choose the numbers of the components of the systems and network to attack and reinforce, respectively. The costs and benefits of attacks and reinforcements are characterized using the sum-form, product-form and composite utility functions, each composed of a survival probability term and a component cost term. We present a two-level characterization of the correlations within the infrastructure: (i) the aggregate failure correlation function specifies the infrastructure failure probability given the failure of an individual system or network, and (ii) the survival probabilities of the systems and network satisfy first-order differential conditions that capture the component-level correlations using multiplier functions. We derive Nash equilibrium conditions that provide expressions for individual system survival probabilities and also the expected infrastructure capacity specified by the total number of operational components. We apply these results to derive and analyze defense strategies for distributed cloud computing infrastructures using cyber-physical models. PMID:29751588

Limits of localized control in extended nonlinear systems

NASA Astrophysics Data System (ADS)

Handel, Andreas

We investigate the limits of localized linear control in spatially extended, nonlinear systems. Spatially extended, nonlinear systems can be found in virtually every field of engineering and science. An important category of such systems are fluid flows. Fluid flows play an important role in many commercial applications, for instance in the chemical, pharmaceutical and food-processing industries. Other important fluid flows include air- or water flows around cars, planes or ships. In all these systems, it is highly desirable to control the flow of the respective fluid. For instance control of the air flow around an airplane or car leads to better fuel-economy and reduced noise production. Usually, it is impossible to apply control everywhere. Consider an airplane: It would not be feasibly to cover the whole body of the plane with control units. Instead, one can place the control units at localized regions, such as points along the edge of the wings, spaced as far apart from each other as possible. These considerations lead to an important question: For a given system, what is the minimum number of localized controllers that still ensures successful control? Too few controllers will not achieve control, while using too many leads to unnecessary expenses and wastes resources. To answer this question, we study localized control in a class of model equations. These model equations are good representations of many real fluid flows. Using these equations, we show how one can design localized control that renders the system stable. We study the properties of the control and derive several expressions that allow us to determine the limits of successful control. We show how the number of controllers that are needed for successful control depends on the size and type of the system, as well as the way control is implemented. We find that especially the nonlinearities and the amount of noise present in the system play a crucial role. This analysis allows us to determine under

CRISPR-Cas Defense System and Potential Prophages in Cyanobacteria Associated with the Coral Black Band Disease

PubMed Central

Buerger, Patrick; Wood-Charlson, Elisha M.; Weynberg, Karen D.; Willis, Bette L.; van Oppen, Madeleine J. H.

2016-01-01

Understanding how pathogens maintain their virulence is critical to developing tools to mitigate disease in animal populations. We sequenced and assembled the first draft genome of Roseofilum reptotaenium AO1, the dominant cyanobacterium underlying pathogenicity of the virulent coral black band disease (BBD), and analyzed parts of the BBD-associated Geitlerinema sp. BBD_1991 genome in silico. Both cyanobacteria are equipped with an adaptive, heritable clustered regularly interspaced short palindromic repeats (CRISPR)-Cas defense system type I-D and have potential virulence genes located within several prophage regions. The defense system helps to prevent infection by viruses and mobile genetic elements via identification of short fingerprints of the intruding DNA, which are stored as templates in the bacterial genome, in so-called “CRISPRs.” Analysis of CRISPR target sequences (protospacers) revealed an unusually high number of self-targeting spacers in R. reptotaenium AO1 and extraordinary long CRIPSR arrays of up to 260 spacers in Geitlerinema sp. BBD_1991. The self-targeting spacers are unlikely to be a form of autoimmunity; instead these target an incomplete lysogenic bacteriophage. Lysogenic virus induction experiments with mitomycin C and UV light did not reveal an actively replicating virus population in R. reptotaenium AO1 cultures, suggesting that phage functionality is compromised or excision could be blocked by the CRISPR-Cas system. Potential prophages were identified in three regions of R. reptotaenium AO1 and five regions of Geitlerinema sp. BBD_1991, containing putative BBD relevant virulence genes, such as an NAD-dependent epimerase/dehydratase (a homolog in terms of functionality to the third and fourth most expressed gene in BBD), lysozyme/metalloendopeptidases and other lipopolysaccharide modification genes. To date, viruses have not been considered to be a component of the BBD consortium or a contributor to the virulence of R. reptotaenium

CRISPR-Cas Defense System and Potential Prophages in Cyanobacteria Associated with the Coral Black Band Disease.

PubMed

Buerger, Patrick; Wood-Charlson, Elisha M; Weynberg, Karen D; Willis, Bette L; van Oppen, Madeleine J H

2016-01-01

Understanding how pathogens maintain their virulence is critical to developing tools to mitigate disease in animal populations. We sequenced and assembled the first draft genome of Roseofilum reptotaenium AO1, the dominant cyanobacterium underlying pathogenicity of the virulent coral black band disease (BBD), and analyzed parts of the BBD-associated Geitlerinema sp. BBD_1991 genome in silico . Both cyanobacteria are equipped with an adaptive, heritable clustered regularly interspaced short palindromic repeats (CRISPR)-Cas defense system type I-D and have potential virulence genes located within several prophage regions. The defense system helps to prevent infection by viruses and mobile genetic elements via identification of short fingerprints of the intruding DNA, which are stored as templates in the bacterial genome, in so-called "CRISPRs." Analysis of CRISPR target sequences (protospacers) revealed an unusually high number of self-targeting spacers in R. reptotaenium AO1 and extraordinary long CRIPSR arrays of up to 260 spacers in Geitlerinema sp. BBD_1991. The self-targeting spacers are unlikely to be a form of autoimmunity; instead these target an incomplete lysogenic bacteriophage. Lysogenic virus induction experiments with mitomycin C and UV light did not reveal an actively replicating virus population in R. reptotaenium AO1 cultures, suggesting that phage functionality is compromised or excision could be blocked by the CRISPR-Cas system. Potential prophages were identified in three regions of R. reptotaenium AO1 and five regions of Geitlerinema sp. BBD_1991, containing putative BBD relevant virulence genes, such as an NAD-dependent epimerase/dehydratase (a homolog in terms of functionality to the third and fourth most expressed gene in BBD), lysozyme/metalloendopeptidases and other lipopolysaccharide modification genes. To date, viruses have not been considered to be a component of the BBD consortium or a contributor to the virulence of R. reptotaenium AO1

75 FR 20954 - Defense Federal Acquisition Regulation Supplement; Organizational Conflicts of Interest in Major...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-22

... DEPARTMENT OF DEFENSE Defense Acquisition Regulations System 48 CFR Parts 202, 203, 212, and 252 RIN 0750-AG63 Defense Federal Acquisition Regulation Supplement; Organizational Conflicts of Interest... System, Department of Defense (DoD). ACTION: Proposed rule with request for comments. SUMMARY: DoD is...

Hitting the sweet spot-glycans as targets of fungal defense effector proteins.

PubMed

Künzler, Markus

2015-05-06

Organisms which rely solely on innate defense systems must combat a large number of antagonists with a comparably low number of defense effector molecules. As one solution of this problem, these organisms have evolved effector molecules targeting epitopes that are conserved between different antagonists of a specific taxon or, if possible, even of different taxa. In order to restrict the activity of the defense effector molecules to physiologically relevant taxa, these target epitopes should, on the other hand, be taxon-specific and easily accessible. Glycans fulfill all these requirements and are therefore a preferred target of defense effector molecules, in particular defense proteins. Here, we review this defense strategy using the example of the defense system of multicellular (filamentous) fungi against microbial competitors and animal predators.

Study of the measurement of defense style using Bond's Defense Style Questionnaire.

PubMed

Nishimura, R

1998-08-01

Two hundred and seventy healthy university students were surveyed in December 1995 using Bond's Defense Style Questionnaire (DSQ) to measure the subjects' defense mechanisms. At the same time, a survey using Byrne's R-S Scale (Repression-Sensitization Scale) of the MMPI (Minnesota multiphasic personality inventory) and five psychiatric symptom indexes (anxiety, sense of inadequacy, sensitivity, depression and impulsive anger) selected from the CMI (Cornell Medical Index-Health Questionnaire) was conducted. Three factors were extracted from the DSQ through factor analysis: immature defenses, neurotic defenses, and mature defenses. The results of analysis of variance revealed the following: (i) for anxiety and anxiety related symptoms, both immature defenses and neurotic defenses indicated principal effect; (ii) for impulsive anger and depression, immature defenses presented principal effect; and (iii) for sensitivity and impulsive anger, interaction between a mature defense style and neurotic defense style was noted. The relationship between defense styles and psychiatric symptoms in healthy people is studied in this paper.

Research on air and missile defense task allocation based on extended contract net protocol

NASA Astrophysics Data System (ADS)

Zhang, Yunzhi; Wang, Gang

2017-10-01

Based on the background of air and missile defense distributed element corporative engagement, the interception task allocation problem of multiple weapon units with multiple targets under network condition is analyzed. Firstly, a mathematical model of task allocation is established by combat task decomposition. Secondly, the initialization assignment based on auction contract and the adjustment allocation scheme based on swap contract were introduced to the task allocation. Finally, through the simulation calculation of typical situation, the model can be used to solve the task allocation problem in complex combat environment.

Induced plant defenses, host–pathogen interactions, and forest insect outbreaks

PubMed Central

Elderd, Bret D.; Rehill, Brian J.; Haynes, Kyle J.; Dwyer, Greg

2013-01-01

Cyclic outbreaks of defoliating insects devastate forests, but their causes are poorly understood. Outbreak cycles are often assumed to be driven by density-dependent mortality due to natural enemies, because pathogens and predators cause high mortality and because natural-enemy models reproduce fluctuations in defoliation data. The role of induced defenses is in contrast often dismissed, because toxic effects of defenses are often weak and because induced-defense models explain defoliation data no better than natural-enemy models. Natural-enemy models, however, fail to explain gypsy moth outbreaks in North America, in which outbreaks in forests with a higher percentage of oaks have alternated between severe and mild, whereas outbreaks in forests with a lower percentage of oaks have been uniformly moderate. Here we show that this pattern can be explained by an interaction between induced defenses and a natural enemy. We experimentally induced hydrolyzable-tannin defenses in red oak, to show that induction reduces variability in a gypsy moth’s risk of baculovirus infection. Because this effect can modulate outbreak severity and because oaks are the only genus of gypsy moth host tree that can be induced, we extended a natural-enemy model to allow for spatial variability in inducibility. Our model shows alternating outbreaks in forests with a high frequency of oaks, and uniform outbreaks in forests with a low frequency of oaks, matching the data. The complexity of this effect suggests that detecting effects of induced defenses on defoliator cycles requires a combination of experiments and models. PMID:23966566

The evolution of a teledentistry system within the Department of Defense.

PubMed Central

Rocca, M. A.; Kudryk, V. L.; Pajak, J. C.; Morris, T.

1999-01-01

Total Dental Access (TDA) is the teledentistry project within the Department of Defense. This project enables referring dentists from the US Armed Forces to consult with specialists on the status of a patient. TDA focuses on three areas of dentistry: patient care, continuing education and dentist-laboratory communications. One of the goals of this project is to increase patient access to quality dental care. The other goal is to establish a cost effective telemedicine system. This paper describes the evolution of a teledentistry system, the main features of POTS-based, ISDN-based and Web-based systems used, advantages, disadvantages and cost-effectiveness of these systems. Data has been collected on the frequency of use, technical problems occurred, avoided patient or specialist travel and the total number of consults. A cost-effectiveness analysis has been conducted on the data collected. The results of this analysis will be presented. PMID:10566495

The evolution of a teledentistry system within the Department of Defense.

PubMed

Rocca, M A; Kudryk, V L; Pajak, J C; Morris, T

1999-01-01

Total Dental Access (TDA) is the teledentistry project within the Department of Defense. This project enables referring dentists from the US Armed Forces to consult with specialists on the status of a patient. TDA focuses on three areas of dentistry: patient care, continuing education and dentist-laboratory communications. One of the goals of this project is to increase patient access to quality dental care. The other goal is to establish a cost effective telemedicine system. This paper describes the evolution of a teledentistry system, the main features of POTS-based, ISDN-based and Web-based systems used, advantages, disadvantages and cost-effectiveness of these systems. Data has been collected on the frequency of use, technical problems occurred, avoided patient or specialist travel and the total number of consults. A cost-effectiveness analysis has been conducted on the data collected. The results of this analysis will be presented.

Cyber Defense Management

DTIC Science & Technology

2016-09-01

manage cyber security is often a verymanual and labor intensive process. When a crisis hits, DoD responses range from highly automatedand instrumented...DSB Task Force Report on Cyber Defense Management September 2016 (U) This page intentionally blank REPORT OF THE DEFENSE SCIENCE BOARD STUDY ON Cyber ...DEFENSE FOR ACQUISITION, TECHNOLOGY & LOGISTICS SUBJECT: Final Report of the Defense Science Board (DSB) Task Force on Cyber Defense Management I am

A Model of an Integrated Air Defense System (IADS) for the TACOPS program

DTIC Science & Technology

1991-09-01

SUBJECT TERMS (Continue on reverse If necessary and Identify by block number) FIELD GROUP SUB-GROUP Integrated Air Defense System, iADS, TACOPS...needed. Selection criteria for picking a Measurement Of Effectiveness (MOE) are presented. Acceslon For I NTIS CRA&I DTIC TAB 0 Unannouticed 1 ...Justification B y ............................................... Di.,t ibiation Av.iabilily Codes Avai i:.djor Dist A- 1 THESIS DISCLAIMER The reader is cautioned

Effects of parasite pressure on parasite mortality and reproductive output in a rodent-flea system: inferring host defense trade-offs.

PubMed

Warburton, Elizabeth M; Kam, Michael; Bar-Shira, Enav; Friedman, Aharon; Khokhlova, Irina S; Koren, Lee; Asfur, Mustafa; Geffen, Eli; Kiefer, Daniel; Krasnov, Boris R; Degen, A Allan

2016-09-01

Evaluating host resistance via parasite fitness helps place host-parasite relationships within evolutionary and ecological contexts; however, few studies consider both these processes simultaneously. We investigated how different levels of parasite pressure affect parasite mortality and reproductive success in relationship to host defense efforts, using the rodent Gerbillus nanus and the flea Xenopsylla conformis as a host-parasite system. Fifteen immune-naïve male rodents were infested with 20, 50, or 100 fleas for four weeks. During this time number of new imagoes produced per adult flea (our flea reproductive output metric), flea mortality, and change in circulating anti-flea immunoglobulin G (our measure of adaptive immune defense) were monitored. Three hypotheses guided this work: (1) increasing parasite pressure would heighten host defenses; (2) parasite mortality would increase and parasite reproductive output would decrease with increasing investment in host defense; and (3) hosts under high parasite pressure could invest in behavioral and/or immune responses. We predicted that at high infestation levels (a) parasite mortality would increase; (b) flea reproductive output per individual would decrease; and (c) host circulating anti-flea antibody levels would increase. The hypotheses were partially supported. Flea mortality significantly increased and flea reproductive output significantly decreased as flea pressure increased. Host adaptive immune defense did not significantly change with increasing flea pressure. Therefore, we inferred that investment in host behavioral defense, either alone or in combination with density-dependent effects, may be more efficient at increasing flea mortality and decreasing flea reproductive output than antibody production during initial infestation in this system.

Pipecolic Acid Orchestrates Plant Systemic Acquired Resistance and Defense Priming via Salicylic Acid-Dependent and -Independent Pathways

PubMed Central

Bernsdorff, Friederike; Döring, Anne-Christin; Gruner, Katrin; Schuck, Stefan; Bräutigam, Andrea; Zeier, Jürgen

2016-01-01

We investigated the relationships of the two immune-regulatory plant metabolites, salicylic acid (SA) and pipecolic acid (Pip), in the establishment of plant systemic acquired resistance (SAR), SAR-associated defense priming, and basal immunity. Using SA-deficient sid2, Pip-deficient ald1, and sid2 ald1 plants deficient in both SA and Pip, we show that SA and Pip act both independently from each other and synergistically in Arabidopsis thaliana basal immunity to Pseudomonas syringae. Transcriptome analyses reveal that SAR establishment in Arabidopsis is characterized by a strong transcriptional response systemically induced in the foliage that prepares plants for future pathogen attack by preactivating multiple stages of defense signaling and that SA accumulation upon SAR activation leads to the downregulation of photosynthesis and attenuated jasmonate responses systemically within the plant. Whereas systemic Pip elevations are indispensable for SAR and necessary for virtually the whole transcriptional SAR response, a moderate but significant SA-independent component of SAR activation and SAR gene expression is revealed. During SAR, Pip orchestrates SA-dependent and SA-independent priming of pathogen responses in a FLAVIN-DEPENDENT-MONOOXYGENASE1 (FMO1)-dependent manner. We conclude that a Pip/FMO1 signaling module acts as an indispensable switch for the activation of SAR and associated defense priming events and that SA amplifies Pip-triggered responses to different degrees in the distal tissue of SAR-activated plants. PMID:26672068

Pipecolic Acid Orchestrates Plant Systemic Acquired Resistance and Defense Priming via Salicylic Acid-Dependent and -Independent Pathways.

PubMed

Bernsdorff, Friederike; Döring, Anne-Christin; Gruner, Katrin; Schuck, Stefan; Bräutigam, Andrea; Zeier, Jürgen

2016-01-01

We investigated the relationships of the two immune-regulatory plant metabolites, salicylic acid (SA) and pipecolic acid (Pip), in the establishment of plant systemic acquired resistance (SAR), SAR-associated defense priming, and basal immunity. Using SA-deficient sid2, Pip-deficient ald1, and sid2 ald1 plants deficient in both SA and Pip, we show that SA and Pip act both independently from each other and synergistically in Arabidopsis thaliana basal immunity to Pseudomonas syringae. Transcriptome analyses reveal that SAR establishment in Arabidopsis is characterized by a strong transcriptional response systemically induced in the foliage that prepares plants for future pathogen attack by preactivating multiple stages of defense signaling and that SA accumulation upon SAR activation leads to the downregulation of photosynthesis and attenuated jasmonate responses systemically within the plant. Whereas systemic Pip elevations are indispensable for SAR and necessary for virtually the whole transcriptional SAR response, a moderate but significant SA-independent component of SAR activation and SAR gene expression is revealed. During SAR, Pip orchestrates SA-dependent and SA-independent priming of pathogen responses in a FLAVIN-DEPENDENT-MONOOXYGENASE1 (FMO1)-dependent manner. We conclude that a Pip/FMO1 signaling module acts as an indispensable switch for the activation of SAR and associated defense priming events and that SA amplifies Pip-triggered responses to different degrees in the distal tissue of SAR-activated plants. © 2016 American Society of Plant Biologists. All rights reserved.

Defensive medicine and outcomes for medical malpractice liability.

PubMed

Genovese, Umberto; Amato, Simona; Del Sordo, Sara; Mobilia, Francesca; Casali, Michelangelo B

2014-01-01

Defensive medicine is a significant force driving the high costs of healthcare systems and has a substantial influence on physicians' behavior because they primarily concern about malpractice liability and not patient's health protection. This attitude disagrees with deontological duties and could impair physicians' ability of judgment and clinical reasoning. Reducing defensive medicine also could mean improving the quality in healthcare systems and eliminating unnecessary costs.

A Mean Field Approach to Self-Organization in Spatially Extended Perception-Action and Psychological Systems

NASA Astrophysics Data System (ADS)

Frank, Till; Beek, Peter

It is argued that perception-action systems should be considered as spatially extended systems on account of (i) the presence of spatially distributed synchronized brain activity during the performance of perceptual-motor tasks, and (ii) the failure of conventional zero-dimensional theoretical approaches to deal with multistable perception-action systems and hysteresis in the presence of noise. It is shown that in spatially extended systems self-organization can arise due to the emergence of mean field attractors. This mean field approach is exemplified for a particular class of perception-action systems, namely, rhythmic movements. In addition, clinical implications of the mean field approach and the notion of spatially extended perception-action systems are briefly discussed in the context of psychotherapy and Parkinson's disease.

Defense Medical Human Resources System-internet (DMHRSi): A Case Study on Compliance and Accuracy

DTIC Science & Technology

2009-06-02

including suggestions for reducing the burden, to Department of Defense, Washington Headquarters Services, Directorate for Information Operations ...military, contractor operated facilities. The hospital also houses the second oldest Family Practice Residency in the Army (DeWitt, 2008). The...collection and analysis of financial, workload, and personnel data within the organization. The MHS utilizes information managemen * systems like the

Dynamic defense workshop :

DOE Office of Scientific and Technical Information (OSTI.GOV)

Crosby, Sean Michael; Doak, Justin E.; Haas, Jason Juedes.

2013-02-01

On September 5th and 6th, 2012, the Dynamic Defense Workshop: From Research to Practice brought together researchers from academia, industry, and Sandia with the goals of increasing collaboration between Sandia National Laboratories and external organizations, de ning and un- derstanding dynamic, or moving target, defense concepts and directions, and gaining a greater understanding of the state of the art for dynamic defense. Through the workshop, we broadened and re ned our de nition and understanding, identi ed new approaches to inherent challenges, and de ned principles of dynamic defense. Half of the workshop was devoted to presentations of current state-of-the-artmore » work. Presentation topics included areas such as the failure of current defenses, threats, techniques, goals of dynamic defense, theory, foundations of dynamic defense, future directions and open research questions related to dynamic defense. The remainder of the workshop was discussion, which was broken down into sessions on de ning challenges, applications to host or mobile environments, applications to enterprise network environments, exploring research and operational taxonomies, and determining how to apply scienti c rigor to and investigating the eld of dynamic defense.« less

The glutathione defense system in the pathogenesis of rheumatoid arthritis.

PubMed

Hassan, M Q; Hadi, R A; Al-Rawi, Z S; Padron, V A; Stohs, S J

2001-01-01

In order to assess a possible role of the natural glutathione defense system in the pathogenesis of rheumatoid arthritis (RA), serum reduced glutathione levels (GSH), glutathione reductase (GSR), glutathione S-transferase (GST), glutathione peroxidase (GSH-Px) and alkaline phosphatase (ALP) activities, lipid peroxidation (MDA content) and indexes of inflammation were evaluated in 58 rheumatic patients. Rheumatoid athritis was associated with significant depletion (ca. 50%) in GSH levels compared with normal control subjects. Serum levels of the detoxifying enzymes GSR and GSH-Px decreased by ca. 50% and 45%, respectively, whereas a threefold increase in the activity of GST was observed. A 1.2-fold increase in ALP was observed in patients with RA. These effects were accompanied by a 3.1-fold increase in serum MDA content. The MDA content was higher in RA patients who were seropositive for rheumatoid factor as well as positive for C-reactive proteins. The erythrocyte sedimentation rate for all patients with RA was approximately 13.8-fold higher than for the control group, and was higher among RA patients who were positive for C-reactive proteins and exhibited seropositivity for rheumatoid factor. Patients with RA receiving gold therapy exhibited significantly lower MDA levels whereas all other factors that were measured were not effected. The results support a hypothesis that defense mechanisms against reactive oxygen species are impaired in RA. Copyright 2001 John Wiley & Sons, Ltd.

76 FR 35424 - Information Collection Requirements; Defense Federal Acquisition Regulation Supplement...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-17

... DEPARTMENT OF DEFENSE Defense Acquisition Regulations System Information Collection Requirements; Defense Federal Acquisition Regulation Supplement; Construction and Architect-Engineer Contracts AGENCY..., Construction and Architect-Engineer Contracts, and Related Clauses at DFARS 252.236; OMB Control Number 0704...

Inducible defenses in food webs: Chapter 3.4

USGS Publications Warehouse

Vos, Matthijs; Kooi, Bob W.; DeAngelis, Donald L.; Mooij, Wolf M.; de Ruiter, Peter; Wolters, Volkmar; Moore, John C.; Melville-Smith, Kimberly

2005-01-01

This chapter reviews the predicted effects of induced defenses on trophic structure and two aspects of stability, “local” stability and persistence, as well as presenting novel results on a third, resilience. Food webs are structures of populations in a given location organized according to their predator–prey interactions. Interaction strengths and, therefore, prey defenses are generally recognized as important ecological factors affecting food webs. Despite this, surprisingly, little light has been shed on the food web-level consequences of inducible defenses. Inducible defenses occur in many taxa in both terrestrial and aquatic food webs. They include refuge use, reduced activity, adaptive life history changes, the production of toxins, synomones and extrafloral nectar, and the formation of colonies, helmets, thorns, or spines. In the chapter, theoretical results for the effects of inducible defenses on trophic structure and the three aspects of stability are reviewed. This is done, in part, using bifurcation analysis—a type of analysis that is applied to nonlinear dynamic systems described by a set of ordinary differential or difference equations. The work presented in the chapter suggests that heterogeneity, as caused by induced defenses in prey species, has major effects on the functioning of food webs. Inducible defenses occur in many species in both aquatic and terrestrial systems, and theoretical work indicates they have major effects on important food web properties such as trophic structure, local stability, persistence, and resilience.

Defense Science and Technology RELIANCE. Defense Technology Objectives Success Stories

DTIC Science & Technology

2001-03-01

27 MD.04 Medical Countermeasures for Botulinum Toxin ...flexibility of U.S. forces. Completed. 1998 SPONSORS DoD Chemical and Biological Defense Program MEDICAL COUNTERMEASURES FOR BOTULINUM TOXIN (MD.04) 29...system operates satisfactorily against a high-level jamming environment in the target area. On four AGTFT free flights, the AGTFT flight test vehicles

75 FR 45104 - Information Collection Requirement; Defense Federal Acquisition Regulation Supplement...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-02

... DEPARTMENT OF DEFENSE Defense Acquisition Regulations System [OMB Control Number 0704-0225] Information Collection Requirement; Defense Federal Acquisition Regulation Supplement; Administrative Matters... Supplement (DFARS) Part 204, Administrative Matters, and related clauses at DFARS 252.204; DD Form 2051...

Vertebrate defense against parasites: Interactions between avoidance, resistance, and tolerance.

PubMed

Klemme, Ines; Karvonen, Anssi

2017-01-01

Hosts can utilize different types of defense against the effects of parasitism, including avoidance, resistance, and tolerance. Typically, there is tremendous heterogeneity among hosts in these defense mechanisms that may be rooted in the costs associated with defense and lead to trade-offs with other life-history traits. Trade-offs may also exist between the defense mechanisms, but the relationships between avoidance, resistance, and tolerance have rarely been studied. Here, we assessed these three defense traits under common garden conditions in a natural host-parasite system, the trematode eye-fluke Diplostomum pseudospathaceum and its second intermediate fish host. We looked at host individuals originating from four genetically distinct populations of two closely related salmonid species (Atlantic salmon, Salmo salar and sea trout, Salmo trutta trutta ) to estimate the magnitude of variation in these defense traits and the relationships among them. We show species-specific variation in resistance and tolerance and population-specific variation in resistance. Further, we demonstrate evidence for a trade-off between resistance and tolerance. Our results suggest that the variation in host defense can at least partly result from a compromise between different interacting defense traits, the relative importance of which is likely to be shaped by environmental components. Overall, this study emphasizes the importance of considering different components of the host defense system when making predictions on the outcome of host-parasite interactions.

22 CFR 120.2 - Designation of defense articles and defense services.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 22 Foreign Relations 1 2011-04-01 2011-04-01 false Designation of defense articles and defense services. 120.2 Section 120.2 Foreign Relations DEPARTMENT OF STATE INTERNATIONAL TRAFFIC IN ARMS REGULATIONS PURPOSE AND DEFINITIONS § 120.2 Designation of defense articles and defense services. The Arms...

22 CFR 120.2 - Designation of defense articles and defense services.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 22 Foreign Relations 1 2013-04-01 2013-04-01 false Designation of defense articles and defense services. 120.2 Section 120.2 Foreign Relations DEPARTMENT OF STATE INTERNATIONAL TRAFFIC IN ARMS REGULATIONS PURPOSE AND DEFINITIONS § 120.2 Designation of defense articles and defense services. The Arms...

22 CFR 120.2 - Designation of defense articles and defense services.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Designation of defense articles and defense services. 120.2 Section 120.2 Foreign Relations DEPARTMENT OF STATE INTERNATIONAL TRAFFIC IN ARMS REGULATIONS PURPOSE AND DEFINITIONS § 120.2 Designation of defense articles and defense services. The Arms...

22 CFR 120.2 - Designation of defense articles and defense services.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 22 Foreign Relations 1 2012-04-01 2012-04-01 false Designation of defense articles and defense services. 120.2 Section 120.2 Foreign Relations DEPARTMENT OF STATE INTERNATIONAL TRAFFIC IN ARMS REGULATIONS PURPOSE AND DEFINITIONS § 120.2 Designation of defense articles and defense services. The Arms...

22 CFR 120.44 - Foreign defense article or defense service.

Code of Federal Regulations, 2014 CFR

2014-04-01

... defense service means any article or service described on the U.S. Munitions List of non-U.S. origin... U.S. and foreign origin defense articles and defense services described on the U.S. Munitions List...

Stochastic population dynamics in spatially extended predator-prey systems

NASA Astrophysics Data System (ADS)

Dobramysl, Ulrich; Mobilia, Mauro; Pleimling, Michel; Täuber, Uwe C.

2018-02-01

Spatially extended population dynamics models that incorporate demographic noise serve as case studies for the crucial role of fluctuations and correlations in biological systems. Numerical and analytic tools from non-equilibrium statistical physics capture the stochastic kinetics of these complex interacting many-particle systems beyond rate equation approximations. Including spatial structure and stochastic noise in models for predator-prey competition invalidates the neutral Lotka-Volterra population cycles. Stochastic models yield long-lived erratic oscillations stemming from a resonant amplification mechanism. Spatially extended predator-prey systems display noise-stabilized activity fronts that generate persistent correlations. Fluctuation-induced renormalizations of the oscillation parameters can be analyzed perturbatively via a Doi-Peliti field theory mapping of the master equation; related tools allow detailed characterization of extinction pathways. The critical steady-state and non-equilibrium relaxation dynamics at the predator extinction threshold are governed by the directed percolation universality class. Spatial predation rate variability results in more localized clusters, enhancing both competing species’ population densities. Affixing variable interaction rates to individual particles and allowing for trait inheritance subject to mutations induces fast evolutionary dynamics for the rate distributions. Stochastic spatial variants of three-species competition with ‘rock-paper-scissors’ interactions metaphorically describe cyclic dominance. These models illustrate intimate connections between population dynamics and evolutionary game theory, underscore the role of fluctuations to drive populations toward extinction, and demonstrate how space can support species diversity. Two-dimensional cyclic three-species May-Leonard models are characterized by the emergence of spiraling patterns whose properties are elucidated by a mapping onto a complex

[Extending the palliative approach across the French health system].

PubMed

Mino, Jean-Christophe

2015-11-01

The care provision for people at the end of life requires a palliative care approach to be extended across the whole healthcare system. Access to palliative care for everyone requires training for professionals, support for specialised structures and teams as well as clear political will. Copyright © 2015 Elsevier Masson SAS. All rights reserved.

Design Skills and Prototyping for Defense Systems

DTIC Science & Technology

2015-04-30

however, the utility of prototyping has had a demonstrably mixed record in defense acquisition. Some programs, such as the Manhattan Project , were...almost completely undefined. The first production reactors for the Manhattan Project suffered a near- catastrophic engineering design flaw stemming...architecture, as was seen in the F-117 and Manhattan Project development efforts. Architectural Prototyping Simply maintaining design teams or developing

Silicon induced systemic defense responses in perennial ryegrass against Magnaporthe oryzae infection

USDA-ARS?s Scientific Manuscript database

Sustainable integrated disease management for gray leaf spot of perennial ryegrass may involve use of plant defense elicitors with compatible traditional fungicides to reduce disease incidence and severity. Silicon (Si) is a potential inducer or modulator of plant defenses against different pathogen...

The Strategic Defense Initiative in Soviet Planning and Policy

DTIC Science & Technology

1988-01-01

relentlessly insisted that since the signing of the ABM Treaty in 1972, the Soviet Union has changed its view on the question of homeland defense. By thus...and testing permitted by the ABM Treaty will not be extended as a bargaining chip, regard- less of any reciprocal concessions the Soviets might offer...proceed apace for a number of years. An appropriate mix of technical achievement, budgetary commitment, adjustment to the ABM Treaty, alliance

77 FR 35921 - Defense Federal Acquisition Regulation Supplement: Item Unique Identifier Update (DFARS Case 2011...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-15

... DEPARTMENT OF DEFENSE Defense Acquisition Regulations System 48 CFR Parts 211, 212, 218, 246, 252 and Appendix F to Chapter 2 RIN 0750-AH64 Defense Federal Acquisition Regulation Supplement: Item Unique Identifier Update (DFARS Case 2011-D055) AGENCY: Defense Acquisition Regulations System...

The biocontrol endophytic bacterium Pseudomonas fluorescens PICF7 induces systemic defense responses in aerial tissues upon colonization of olive roots.

PubMed

Gómez-Lama Cabanás, Carmen; Schilirò, Elisabetta; Valverde-Corredor, Antonio; Mercado-Blanco, Jesús

2014-01-01

Pseudomonas fluorescens PICF7, a native olive root endophyte and effective biocontrol agent (BCA) against Verticillium wilt of olive, is able to trigger a broad range of defense responses in root tissues of this woody plant. In order to elucidate whether strain PICF7 also induces systemic defense responses in above-ground organs, aerial tissues of olive plants grown under non-gnotobiotic conditions were collected at different time points after root bacterization with this endophytic BCA. A suppression subtractive hybridization (SSH) cDNA library, enriched in up-regulated genes, was generated. This strategy enabled the identification of 376 ESTs (99 contigs and 277 singlets), many of them related to response to different stresses. Five ESTs, involved in defense responses, were selected to carry out time-course quantitative real-time PCR (qRT-PCR) experiments aiming to: (1) validate the induction of these genes, and (2) shed light on their expression pattern along time (from 1 to 15 days). Induction of olive genes potentially coding for lipoxygenase 2, catalase, 1-aminocyclopropane-1-carboxylate oxidase, and phenylananine ammonia-lyase was thus confirmed at some time points. Computational analysis also revealed that different transcription factors were up-regulated in olive aerial tissues (i.e., JERF, bHLH, WRKY), as previously reported for roots. Results confirmed that root colonization by this endophytic bacterium does not only trigger defense responses in this organ but also mounts a wide array of systemic defense responses in distant tissues (stems, leaves). This sheds light on how olive plants respond to the "non-hostile" colonization by a bacterial endophyte and how induced defense response can contribute to the biocontrol activity of strain PICF7.

The biocontrol endophytic bacterium Pseudomonas fluorescens PICF7 induces systemic defense responses in aerial tissues upon colonization of olive roots

PubMed Central

Gómez-Lama Cabanás, Carmen; Schilirò, Elisabetta; Valverde-Corredor, Antonio; Mercado-Blanco, Jesús

2014-01-01

Pseudomonas fluorescens PICF7, a native olive root endophyte and effective biocontrol agent (BCA) against Verticillium wilt of olive, is able to trigger a broad range of defense responses in root tissues of this woody plant. In order to elucidate whether strain PICF7 also induces systemic defense responses in above-ground organs, aerial tissues of olive plants grown under non-gnotobiotic conditions were collected at different time points after root bacterization with this endophytic BCA. A suppression subtractive hybridization (SSH) cDNA library, enriched in up-regulated genes, was generated. This strategy enabled the identification of 376 ESTs (99 contigs and 277 singlets), many of them related to response to different stresses. Five ESTs, involved in defense responses, were selected to carry out time-course quantitative real-time PCR (qRT-PCR) experiments aiming to: (1) validate the induction of these genes, and (2) shed light on their expression pattern along time (from 1 to 15 days). Induction of olive genes potentially coding for lipoxygenase 2, catalase, 1-aminocyclopropane-1-carboxylate oxidase, and phenylananine ammonia-lyase was thus confirmed at some time points. Computational analysis also revealed that different transcription factors were up-regulated in olive aerial tissues (i.e., JERF, bHLH, WRKY), as previously reported for roots. Results confirmed that root colonization by this endophytic bacterium does not only trigger defense responses in this organ but also mounts a wide array of systemic defense responses in distant tissues (stems, leaves). This sheds light on how olive plants respond to the “non-hostile” colonization by a bacterial endophyte and how induced defense response can contribute to the biocontrol activity of strain PICF7. PMID:25250017

A Strategic Approach to Network Defense: Framing the Cloud

DTIC Science & Technology

2011-03-10

accepted network defensive principles, to reduce risks associated with emerging virtualization capabilities and scalability of cloud computing . This expanded...defensive framework can assist enterprise networking and cloud computing architects to better design more secure systems.

Extended active disturbance rejection controller

NASA Technical Reports Server (NTRS)

Tian, Gang (Inventor); Gao, Zhiqiang (Inventor)

2012-01-01

Multiple designs, systems, methods and processes for controlling a system or plant using an extended active disturbance rejection control (ADRC) based controller are presented. The extended ADRC controller accepts sensor information from the plant. The sensor information is used in conjunction with an extended state observer in combination with a predictor that estimates and predicts the current state of the plant and a co-joined estimate of the system disturbances and system dynamics. The extended state observer estimates and predictions are used in conjunction with a control law that generates an input to the system based in part on the extended state observer estimates and predictions as well as a desired trajectory for the plant to follow.

Extended Active Disturbance Rejection Controller

NASA Technical Reports Server (NTRS)

Gao, Zhiqiang (Inventor); Tian, Gang (Inventor)

2016-01-01

Multiple designs, systems, methods and processes for controlling a system or plant using an extended active disturbance rejection control (ADRC) based controller are presented. The extended ADRC controller accepts sensor information from the plant. The sensor information is used in conjunction with an extended state observer in combination with a predictor that estimates and predicts the current state of the plant and a co-joined estimate of the system disturbances and system dynamics. The extended state observer estimates and predictions are used in conjunction with a control law that generates an input to the system based in part on the extended state observer estimates and predictions as well as a desired trajectory for the plant to follow.

Extended Active Disturbance Rejection Controller

NASA Technical Reports Server (NTRS)

Tian, Gang (Inventor); Gao, Zhiqiang (Inventor)

2014-01-01

Multiple designs, systems, methods and processes for controlling a system or plant using an extended active disturbance rejection control (ADRC) based controller are presented. The extended ADRC controller accepts sensor information from the plant. The sensor information is used in conjunction with an extended state observer in combination with a predictor that estimates and predicts the current state of the plant and a co-joined estimate of the system disturbances and system dynamics. The extended state observer estimates and predictions are used in conjunction with a control law that generates an input to the system based in part on the extended state observer estimates and predictions as well as a desired trajectory for the plant to follow.

Rethinking Defensive Information Warfare

DTIC Science & Technology

2004-06-01

Countless studies, however, have demonstrated the weakness in this system.15 The tension between easily remembered passwords and suffi...vulnerabilities Undiscovered flaws The patch model for Internet security has failed spectacularly. Caida , 2004 Signature-Based Defense Anti virus, intrusion

[Study of defense styles, defenses and coping strategies in alcohol-dependent population].

PubMed

Ribadier, A; Varescon, I

2017-05-01

Defense mechanisms have been seen to greatly change over time and across different definitions made by different theoretical currents. Recently with the definition provided by the DSM IV, defense mechanisms have integrated the concept of coping as a defensive factor. These mechanisms are no longer considered just through a psychodynamic approach but also through a cognitive and behavioral one. In recent years, new theories have therefore integrated these two components of the defensive operation. According to Chabrol and Callahan (2013), defense mechanisms precede coping strategies. In individuals with psychopathological disorders, these authors indicate a relative stability of these mechanisms. Also, we asked about the presence of unique characteristics among people with alcohol dependence. Indeed, studies conducted with people with alcohol dependence highlight the presence of a neurotic defense style and some highly immature defenses (projection, acting out, splitting and somatization). In terms of coping strategies, persons with alcohol dependence preferentially use avoidant strategies and strategies focused on emotion. However, although several studies have been conducted to assess coping strategies and defense styles within a population of individuals with an alcohol problem, at the present time none of them has taken into account all these aspects of defense mechanisms. The aim of this study is therefore to study the defenses and defense styles and coping strategies in an alcohol-dependent population. This multicenter study (3 CHU, 1 center of supportive care and prevention in addiction and 1 clinic) received a favorable opinion of an Institutional Review Board (IRB Registration #: 00001072). Eighty alcohol-dependent individuals responded to a questionnaire assessing sociodemographic characteristics and elements related to the course of consumption. Coping strategies were assessed by means of a questionnaire validated in French: the Brief Cope. The Defense

78 FR 78342 - Extension of Autism Services Demonstration Project for TRICARE Beneficiaries Under the Extended...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-26

... DEPARTMENT OF DEFENSE Office of the Secretary Extension of Autism Services Demonstration Project... (the Department) Enhanced Access to Autism Services Demonstration Project (Autism Demonstration) under the Extended Care Health Option (ECHO) for beneficiaries diagnosed with an Autism Spectrum Disorder...

State-selective optimization of local excited electronic states in extended systems

NASA Astrophysics Data System (ADS)

Kovyrshin, Arseny; Neugebauer, Johannes

2010-11-01

Standard implementations of time-dependent density-functional theory (TDDFT) for the calculation of excitation energies give access to a number of the lowest-lying electronic excitations of a molecule under study. For extended systems, this can become cumbersome if a particular excited state is sought-after because many electronic transitions may be present. This often means that even for systems of moderate size, a multitude of excited states needs to be calculated to cover a certain energy range. Here, we present an algorithm for the selective determination of predefined excited electronic states in an extended system. A guess transition density in terms of orbital transitions has to be provided for the excitation that shall be optimized. The approach employs root-homing techniques together with iterative subspace diagonalization methods to optimize the electronic transition. We illustrate the advantages of this method for solvated molecules, core-excitations of metal complexes, and adsorbates at cluster surfaces. In particular, we study the local π →π∗ excitation of a pyridine molecule adsorbed at a silver cluster. It is shown that the method works very efficiently even for high-lying excited states. We demonstrate that the assumption of a single, well-defined local excitation is, in general, not justified for extended systems, which can lead to root-switching during optimization. In those cases, the method can give important information about the spectral distribution of the orbital transition employed as a guess.

77 FR 34940 - Defense Audit Advisory Committee (DAAC); Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-12

... DEPARTMENT OF DEFENSE Office of the Secretary Defense Audit Advisory Committee (DAAC); Notice of... following Federal advisory committee meeting of the Defense Audit Advisory Committee (DAAC) will be held... reporting processes, systems of internal controls, audit processes, and processes for monitoring compliance...

Optimal defense theory explains deviations from latitudinal herbivory defense hypothesis.

PubMed

Kooyers, Nicholas J; Blackman, Benjamin K; Holeski, Liza M

2017-04-01

The latitudinal herbivory defense hypothesis (LHDH) postulates that the prevalence of species interactions, including herbivory, is greater at lower latitudes, leading to selection for increased levels of plant defense. While latitudinal defense clines may be caused by spatial variation in herbivore pressure, optimal defense theory predicts that clines could also be caused by ecogeographic variation in the cost of defense. For instance, allocation of resources to defense may not increase plant fitness when growing seasons are short and plants must reproduce quickly. Here we use a common garden experiment to survey genetic variation for constitutive and induced phenylpropanoid glycoside (PPG) concentrations across 35 Mimulus guttatus populations over a ~13° latitudinal transect. Our sampling regime is unique among studies of the LHDH in that it allows us to disentangle the effects of growing season length from those of latitude, temperature, and elevation. For five of the seven PPGs surveyed, we find associations between latitude and plant defense that are robust to population structure. However, contrary to the LHDH, only two PPGs were found at higher levels in low latitude populations, and total PPG concentrations were higher at higher latitudes. PPG levels are strongly correlated with growing season length, with higher levels of PPGs in plants from areas with longer growing seasons. Further, flowering time is positively correlated with the concentration of nearly all PPGs, suggesting that there may be a strong trade-off between development time and defense production. Our results reveal that ecogeographic patterns in plant defense may reflect variation in the cost of producing defense compounds in addition to variation in herbivore pressure. Thus, the biogeographic pattern predicted by the LHDH may not be accurate because the underlying factors driving variation in defense, in this case, growing season length, are not always associated with latitude in the same

Transformation of nonlinear discrete-time system into the extended observer form

NASA Astrophysics Data System (ADS)

Kaparin, V.; Kotta, Ü.

2018-04-01

The paper addresses the problem of transforming discrete-time single-input single-output nonlinear state equations into the extended observer form, which, besides the input and output, also depends on a finite number of their past values. Necessary and sufficient conditions for the existence of both the extended coordinate and output transformations, solving the problem, are formulated in terms of differential one-forms, associated with the input-output equation, corresponding to the state equations. An algorithm for transformation of state equations into the extended observer form is proposed and illustrated by an example. Moreover, the considered approach is compared with the method of dynamic observer error linearisation, which likewise is intended to enlarge the class of systems transformable into an observer form.

Ballistic missile defense effectiveness

NASA Astrophysics Data System (ADS)

Lewis, George N.

2017-11-01

The potential effectiveness of ballistic missile defenses today remains a subject of debate. After a brief discussion of terminal and boost phase defenses, this chapter will focus on long-range midcourse defenses. The problems posed by potential countermeasures to such midcourse defenses are discussed as are the sensor capabilities a defense might have available to attempt to discriminate the actual missile warhead in a countermeasures environment. The role of flight testing in assessing ballistic missile defense effectiveness is discussed. Arguments made about effectiveness by missile defense supporters and critics are summarized.

48 CFR 18.202 - Defense or recovery from certain attacks.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Defense or recovery from certain attacks. 18.202 Section 18.202 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACTING METHODS AND CONTRACT TYPES EMERGENCY ACQUISITIONS Emergency Acquisition Flexibilities 18.202 Defense or recovery from certain...

76 FR 72391 - Defense Logistics Agency Revised Regulation 1000.22, Environmental Considerations in Defense...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-23

... DEPARTMENT OF DEFENSE Office of the Secretary [Docket ID DOD-2011-OS-0055] Defense Logistics Agency Revised Regulation 1000.22, Environmental Considerations in Defense Logistics Agency Actions AGENCY: Defense Logistics Agency, Department of Defense. ACTION: Revised Defense Logistics Agency...

Missile Defense: Actions Needed to Improve Transparency and Accountability

DTIC Science & Technology

2011-04-13

suggestions for reducing this burden, to Washington Headquarters Services, Directorate for Information Operations and Reports, 1215 Jefferson Davis Highway...Established resource, schedule, test, operational capacity, technical, and contract baselines for several missile defense systems. It reported...Europe as well as the Ground-based Midcourse Defense system. View GAO-11-555T or key components. For more information, contact Cristina T

75 FR 8927 - Autism Services Demonstration Project for TRICARE Beneficiaries Under the Extended Care Health...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-02-26

... DEPARTMENT OF DEFENSE Office of the Secretary Autism Services Demonstration Project for TRICARE... Access to Autism Services Demonstration Project under the Extended Care Health Option for beneficiaries diagnosed with an Autism Spectrum Disorder (ASD). Under the demonstration, the Department implemented a...

76 FR 80903 - Extension of Autism Services Demonstration Project for TRICARE Beneficiaries Under the Extended...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-27

... DEPARTMENT OF DEFENSE Office of the Secretary Extension of Autism Services Demonstration Project... Enhanced Access to Autism Services Demonstration Project under the Extended Care Health Option for beneficiaries diagnosed with an Autism Spectrum Disorder (ASD). Under the demonstration, the Department...

78 FR 18325 - Defense Transportation Regulation, Part IV

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-26

... received in connection with the Defense Personal Property Program (DP3) Phase III Direct Procurement Method... at http://www.transcom.mil/dtr/part-iv/phaseiii.cfm (DPM SECTION). All identified changes will be... Defense Personal Property System (DPS) Phase III programming projected for FY17. FOR FURTHER INFORMATION...

78 FR 38235 - Defense Federal Acquisition Regulation Supplement; Technical Amendments

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-26

.... DATES: Effective Date: June 26, 2013. FOR FURTHER INFORMATION CONTACT: Mrs. Kortnee Stewart, Defense.... Kortnee Stewart, Editor, Defense Acquisition Regulations System. Therefore, 48 CFR parts 225 and 252 are...

Defense without aggression

DOE Office of Scientific and Technical Information (OSTI.GOV)

Harvey, H.

1988-09-01

In introducing this group of articles on nonoffensive defense the author notes that the prospect of nuclear disarmament in Europe is boosting ideas, which have been around for a decade, from theory to politics. This special section of articles looks at an emerging theory that may reduce reliance on nuclear weapons by bringing stability to the conventional standoff in central Europe. The idea is to rearrange conventional forces so that they can defend but not attack. Under such monikers as nonoffensive defense (the main term used in these articles), nonprovocative defense, defensive defense, reasonable sufficiency, and mutual defensive superiority, thesemore » proposals suggest that nations can restructure weapons, personnel, and strategy to assure their own military security without posing a threat to other nations. 5 refs.« less

Goldwater-Nichols at 30: Defense Reform and Issues for Congress

DTIC Science & Technology

2016-06-02

observers maintain that a reform of the broader interagency system on national security matters is needed. Despite these disagreements, several...Taken together, however, the issues raised by these questions suggest the systemic nature of the challenges with which the Department of Defense...External Defense Expert Reform Proposals ............................................................................ 24 Formulating Requirements

Influence of IR sensor technology on the military and civil defense

NASA Astrophysics Data System (ADS)

Becker, Latika

2006-02-01

Advances in basic infrared science and developments in pertinent technology applications have led to mature designs being incorporated in civil as well as military area defense systems. Military systems include both tactical and strategic, and civil area defense includes homeland security. Technical challenges arise in applying infrared sensor technology to detect and track targets for space and missile defense. Infrared sensors are valuable due to their passive capability, lower mass and power consumption, and their usefulness in all phases of missile defense engagements. Nanotechnology holds significant promise in the near future by offering unique material and physical properties to infrared components. This technology is rapidly developing. This presentation will review the current IR sensor technology, its applications, and future developments that will have an influence in military and civil defense applications.

A Systems Engineering Approach to Aircraft Kinetic Kill Countermeasures Technology: Development of an Active Aircraft Defense System for the C/KC-135 Aircraft. Volume 1

DTIC Science & Technology

1995-12-01

comparison among all candidate systems , the reliability of each aircraft defense would evenly affect the evaluation of each system , and would have the...more reliable data. Obviously the more reliable and accurate the data evaluated though the hierarchy chart, the better the results. 29 IV. System ...1.3.5 System Evaluation ................................................................ 6 1.3.6 Decision M aking

76 FR 36095 - Defense Transportation Regulation, Part IV

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-21

... with the Defense Personal Property Program (DP3) Phase III Domestic Small Shipments (dS2) and... Regulation, Part IV Web site at http://www.transcom.mil/dtr/part-iv/phaseiii.cfm . All identified changes... based on completion of Defense Personal Property System (DPS) Phase III programming projected for FY15...

Summary Report on the Audit of Defense Base Closure and Realignment Budget Data for FYS 1993 and 1994

DTIC Science & Technology

1994-02-14

Jl%«~~ /&■ OFFICE OF THE INSPECTOR GENERAL SUMMARY REPORT ON THE AUDIT OF DEFENSE BASE CLOSURE AND REALIGNMENT BUDGET DATA FOR FYS 1993 AND...COMPTROLLER) AUDITOR GENERAL, DEPARTMENT OF THE ARMY SUBJECT: Summary Report on the Audit of Defense Base Closure and Realignment Budget Data for FYs...Therefore, we are publishing this report in final form. We appreciate the courtesies and cooperation extended to the audit staff. If you have any

78 FR 33993 - Defense Federal Acquisition Regulation Supplement; Clarification of “F” Orders in the Procurement...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-06

... DEPARTMENT OF DEFENSE Defense Acquisition Regulations System 48 CFR Part 204 RIN 0750-AH80 Defense Federal Acquisition Regulation Supplement; Clarification of ``F'' Orders in the Procurement Instrument Identification Number Structure (DFARS Case 2012-D040); Correction AGENCY: Defense Acquisition Regulations System...

76 FR 21849 - Defense Federal Acquisition Regulation Supplement; Ships Bunkers Easy Acquisition (SEA) Card® and...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-19

... DEPARTMENT OF DEFENSE Defense Acquisition Regulations System 48 CFR Part 213 RIN 0750-AH07 Defense Federal Acquisition Regulation Supplement; Ships Bunkers Easy Acquisition (SEA) Card[supreg] and Aircraft Ground Services (DFARS Case 2009-D019) AGENCY: Defense Acquisition Regulations System, Department of...

76 FR 58149 - Defense Federal Acquisition Regulation Supplement; Ships Bunkers Easy Acquisition (SEA) Card® and...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-20

... DEPARTMENT OF DEFENSE Defense Acquisition Regulations System 48 CFR Part 213 RIN 0750-AH07 Defense Federal Acquisition Regulation Supplement; Ships Bunkers Easy Acquisition (SEA) Card[supreg] and Aircraft Ground Services (DFARS Case 2009-D019) AGENCY: Defense Acquisition Regulations System, Department of...

75 FR 54526 - Defense Federal Acquisition Regulation Supplement; Additional Requirements Applicable to...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-08

... Procurement of Major Systems of the Department of Defense.'' DATES: Effective Date: September 8, 2010. FOR... 217 Government procurement. Ynette R. Shelkin, Editor, Defense Acquisition Regulations System. 0... funding or reprogramming for procurement of a major system under a multiyear contract authorized under...

Section 847 Requirements for Senior Defense Officials Seeking Employment with Defense Contractors

DTIC Science & Technology

2016-03-31

847 Requirements for Senior Defense Officials Seeking Employment with Defense Contractors M A R C H 3 1 , 2 0 1 6 Report No. DODIG-2016-070...Senior Defense Officials Seeking Employment with Defense Contractors Visit us at www.dodig.mil March 31, 2016 Objectives The objectives of our project...description of future duties from a Defense contractor . • Some ethics officials issued nonspecific post-Government employment guidance as a Section 847

Comparative Transcriptome Analysis Reveals a Preformed Defense System in Apple Root of a Resistant Genotype of G.935 in the Absence of Pathogen

PubMed Central

Shao, Jonathan; Zhou, Zhe; Davis, Robert E.

2017-01-01

Two apple rootstock genotypes G.935 and B.9 were recently demonstrated to exhibit distinct resistance responses following infection by Pythium ultimum. As part of an effort to elucidate the genetic regulation of apple root resistance to soilborne pathogens, preinoculation transcriptome variations in roots of these two apple rootstock genotypes are hypothesized to contribute to the observed disease resistance phenotypes. Results from current comparative transcriptome analysis demonstrated elevated transcript abundance for many genes which function in a system-wide defense response in the root tissue of the resistant genotype of G.935 in comparison with susceptible B.9. Based on the functional annotation, these differentially expressed genes encode proteins that function in several tiers of defense responses, such as pattern recognition receptors for pathogen detection and subsequent signal transduction, defense hormone biosynthesis and signaling, transcription factors with known roles in defense activation, enzymes of secondary metabolism, and various classes of resistance proteins. The data set suggested a more poised status, which is ready to defend pathogen infection, in the root tissues of resistant genotype of G.935, compared to the susceptible B.9. The significance of preformed defense in the absence of a pathogen toward overall resistance phenotypes in apple root and the potential fitness cost due to the overactivated defense system were discussed. PMID:28465679

Prevalence and Mechanisms of Dynamic Chemical Defenses in Tropical Sponges

PubMed Central

Rohde, Sven; Nietzer, Samuel; Schupp, Peter J.

2015-01-01

Sponges and other sessile invertebrates are lacking behavioural escape or defense mechanisms and rely therefore on morphological or chemical defenses. Studies from terrestrial systems and marine algae demonstrated facultative defenses like induction and activation to be common, suggesting that sessile marine organisms also evolved mechanisms to increase the efficiency of their chemical defense. However, inducible defenses in sponges have not been investigated so far and studies on activated defenses are rare. We investigated whether tropical sponge species induce defenses in response to artificial predation and whether wounding triggers defense activation. Additionally, we tested if these mechanisms are also used to boost antimicrobial activity to avoid bacterial infection. Laboratory experiments with eight pacific sponge species showed that 87% of the tested species were chemically defended. Two species, Stylissa massa and Melophlus sarasinorum, induced defenses in response to simulated predation, which is the first demonstration of induced antipredatory defenses in marine sponges. One species, M. sarasinorum, also showed activated defense in response to wounding. Interestingly, 50% of the tested sponge species demonstrated induced antimicrobial defense. Simulated predation increased the antimicrobial defenses in Aplysinella sp., Cacospongia sp., M. sarasinorum, and S. massa. Our results suggest that wounding selects for induced antimicrobial defenses to protect sponges from pathogens that could otherwise invade the sponge tissue via feeding scars. PMID:26154741

How noise and coupling influence leading indicators of population extinction in a spatially extended ecological system.

PubMed

O'Regan, Suzanne M

2018-12-01

Anticipating critical transitions in spatially extended systems is a key topic of interest to ecologists. Gradually declining metapopulations are an important example of a spatially extended biological system that may exhibit a critical transition. Theory for spatially extended systems approaching extinction that accounts for environmental stochasticity and coupling is currently lacking. Here, we develop spatially implicit two-patch models with additive and multiplicative forms of environmental stochasticity that are slowly forced through population collapse, through changing environmental conditions. We derive patch-specific expressions for candidate indicators of extinction and test their performance via a simulation study. Coupling and spatial heterogeneities decrease the magnitude of the proposed indicators in coupled populations relative to isolated populations, and the noise regime and the degree of coupling together determine trends in summary statistics. This theory may be readily applied to other spatially extended ecological systems, such as coupled infectious disease systems on the verge of elimination.

48 CFR 752.228-3 - Worker's compensation insurance (Defense Base Act).

Code of Federal Regulations, 2010 CFR

2010-10-01

... insurance (Defense Base Act). 752.228-3 Section 752.228-3 Federal Acquisition Regulations System AGENCY FOR... Clauses 752.228-3 Worker's compensation insurance (Defense Base Act). As prescribed in 728.309, the... contracting officer. (a) The Contractor agrees to procure Defense Base Act (DBA) insurance pursuant to the...

48 CFR 752.228-3 - Worker's compensation insurance (Defense Base Act).

Code of Federal Regulations, 2011 CFR

2011-10-01

... insurance (Defense Base Act). 752.228-3 Section 752.228-3 Federal Acquisition Regulations System AGENCY FOR... Clauses 752.228-3 Worker's compensation insurance (Defense Base Act). As prescribed in 728.309, the... contracting officer. (a) The Contractor agrees to procure Defense Base Act (DBA) insurance pursuant to the...

48 CFR 52.228-3 - Workers' Compensation Insurance (Defense Base Act).

Code of Federal Regulations, 2014 CFR

2014-10-01

... Insurance (Defense Base Act). 52.228-3 Section 52.228-3 Federal Acquisition Regulations System FEDERAL... Provisions and Clauses 52.228-3 Workers' Compensation Insurance (Defense Base Act). As prescribed in 28.309(a), insert the following clause: Workers' Compensation Insurance (Defense Base Act) (JUL 2014) (a) The...

48 CFR 752.228-3 - Worker's compensation insurance (Defense Base Act).

Code of Federal Regulations, 2014 CFR

2014-10-01

... insurance (Defense Base Act). 752.228-3 Section 752.228-3 Federal Acquisition Regulations System AGENCY FOR... Clauses 752.228-3 Worker's compensation insurance (Defense Base Act). As prescribed in 728.309, the... contracting officer. (a) The Contractor agrees to procure Defense Base Act (DBA) insurance pursuant to the...

48 CFR 752.228-3 - Worker's compensation insurance (Defense Base Act).

Code of Federal Regulations, 2012 CFR

2012-10-01

... insurance (Defense Base Act). 752.228-3 Section 752.228-3 Federal Acquisition Regulations System AGENCY FOR... Clauses 752.228-3 Worker's compensation insurance (Defense Base Act). As prescribed in 728.309, the... contracting officer. (a) The Contractor agrees to procure Defense Base Act (DBA) insurance pursuant to the...

48 CFR 752.228-3 - Worker's compensation insurance (Defense Base Act).

Code of Federal Regulations, 2013 CFR

2013-10-01

... insurance (Defense Base Act). 752.228-3 Section 752.228-3 Federal Acquisition Regulations System AGENCY FOR... Clauses 752.228-3 Worker's compensation insurance (Defense Base Act). As prescribed in 728.309, the... contracting officer. (a) The Contractor agrees to procure Defense Base Act (DBA) insurance pursuant to the...

48 CFR 52.228-3 - Workers' Compensation Insurance (Defense Base Act).

Code of Federal Regulations, 2011 CFR

2011-10-01

... Insurance (Defense Base Act). 52.228-3 Section 52.228-3 Federal Acquisition Regulations System FEDERAL... Provisions and Clauses 52.228-3 Workers' Compensation Insurance (Defense Base Act). As prescribed in 28.309(a), insert the following clause: Workers' Compensation Insurance (Defense Base Act) (APR 1984) The Contractor...

48 CFR 52.228-3 - Workers' Compensation Insurance (Defense Base Act).

Code of Federal Regulations, 2013 CFR

2013-10-01

... Insurance (Defense Base Act). 52.228-3 Section 52.228-3 Federal Acquisition Regulations System FEDERAL... Provisions and Clauses 52.228-3 Workers' Compensation Insurance (Defense Base Act). As prescribed in 28.309(a), insert the following clause: Workers' Compensation Insurance (Defense Base Act) (APR 1984) The Contractor...

48 CFR 652.228-70 - Defense Base Act-Covered Contractor Employees.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 48 Federal Acquisition Regulations System 4 2011-10-01 2011-10-01 false Defense Base Act-Covered....228-70 Defense Base Act—Covered Contractor Employees. As prescribed in 628.309-70(a), insert the following provision: Defense Base Act—Covered Contractor Employees (JUN 2006) (a) Bidders/offerors shall...

48 CFR 52.228-3 - Workers' Compensation Insurance (Defense Base Act).

Code of Federal Regulations, 2012 CFR

2012-10-01

... Insurance (Defense Base Act). 52.228-3 Section 52.228-3 Federal Acquisition Regulations System FEDERAL... Provisions and Clauses 52.228-3 Workers' Compensation Insurance (Defense Base Act). As prescribed in 28.309(a), insert the following clause: Workers' Compensation Insurance (Defense Base Act) (APR 1984) The Contractor...

48 CFR 52.228-3 - Workers' Compensation Insurance (Defense Base Act).

Code of Federal Regulations, 2010 CFR

2010-10-01

... Insurance (Defense Base Act). 52.228-3 Section 52.228-3 Federal Acquisition Regulations System FEDERAL... Provisions and Clauses 52.228-3 Workers' Compensation Insurance (Defense Base Act). As prescribed in 28.309(a), insert the following clause: Workers' Compensation Insurance (Defense Base Act) (APR 1984) The Contractor...

48 CFR 652.228-70 - Defense Base Act-Covered Contractor Employees.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Defense Base Act-Covered....228-70 Defense Base Act—Covered Contractor Employees. As prescribed in 628.309-70(a), insert the following provision: Defense Base Act—Covered Contractor Employees (JUN 2006) (a) Bidders/offerors shall...

Definition study for an extended manned test of a regenerative life support system

NASA Technical Reports Server (NTRS)

1971-01-01

A program was defined which consists of extended ground-based manned tests of regenerative life support systems. The tests are to evaluate prototypes of advanced life support systems under operational, integrated conditions, thus providing data for the design of efficient environmental control and life support systems for use in long-duration space missions. The requirements are defined for test operations to provide a simulation of an orbiting space laboratory. The features of Phase A and B programs are described. These tests use proven backup equipment to ensure successful evaluation of the advanced subsystems. A pre-tests all-systems checkout period is provided to minimize equipment problems during extended testing and to familiarize all crew and operating staff members with test equipment and procedures.

Results from a national survey of Crown prosecutors and defense counsel on impaired driving in Canada: a "System Improvements" perspective.

PubMed

Robertson, Robyn; Vanlaar, Ward; Simpson, Herb; Boase, Paul

2009-01-01

This article summarizes the main findings from a study designed to examine the legal process in Canada as it applies to alcohol-impaired driving from the point of view of Crown prosecutors and defense counsel, and to identify evidentiary or procedural factors that may impact the legal process, the rights of the accused, and interactions of all parts in the legal process. The data in this study were collected by means of a survey that was mailed out to the population of Crown prosecutors and defense counsel in Canada. In total, 765 prosecutors and 270 defense lawyers or an estimated 33% of all Canadian prosecutors and 15% of defense lawyers completed and returned the questionnaire. The "systems improvement" paradigm was used to interpret the findings and draw conclusions. Such an approach acknowledges the importance of the context in which countermeasures are implemented and delivered and the structures or entities used to deliver countermeasures to a designated target group. Results on type of charges and breath alcohol concentration, caseload, case outcomes, case preparation time, conviction rate at trial and overall conviction rate, reasons for acquittals and time to resolve cases are described. The findings from this national survey suggest that there are important challenges within the criminal justice system that impede the effective and efficient processing of impaired driving cases. Some of these challenges occur as a function of practices and policies, while others occur as a function of legislation. This study illustrates that a "system improvements" approach that acknowledges the importance of all elements of the criminal justice system and the interaction between those elements, can be beneficial in overcoming the alcohol-impaired driving problem.

Teaching Psychological Defense Mechanisms: "The Defense Mechanisms Game."

ERIC Educational Resources Information Center

Waugh, Charles G.

1980-01-01

Presents the rules for an educational game in which students reinforce psychology lecture material by creating and dramatizing defense mechanisms such as reaction formation, displacement, and fantasy. Provides definitions and examples of the various defense mechanisms that can be portrayed. (JP)

Information Resource Management Planning in the Office of the Under Secretary of Defense (Acquisition)

DTIC Science & Technology

1989-08-01

Include in this plan the role of the Defense Technical Information Center (DTIC), the Defense Technology Security Administration ( DTSA ), and ODDR&E’s...DTIC = Defense Technical Information Center DTSA = Defense Technology Security Administration DUSD = Deputy Under Secretary of Defense Gloss. 2 DUSD...technologically sensitive requests. The Defense Technology Security Administi ation ( DTSA ) is developing a large system to track foreign military sales

48 CFR 652.228-74 - Defense Base Act insurance rates-Limitation.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 48 Federal Acquisition Regulations System 4 2011-10-01 2011-10-01 false Defense Base Act insurance....228-74 Defense Base Act insurance rates—Limitation. As prescribed in 628.309-70(c), insert the following provision: Defense Base Act Insurance Rates—Limitation (JUN 2006) (a) The Department of State has...

Cost and Time Overruns for Major Defense Acquisition Programs: An Annotated Brief

DTIC Science & Technology

2011-04-30

Logistics Management) • Director, Strategic Systems Programs Office • Deputy Director, Acquisition Career Management, US Army • Defense Business...acquisition and industrial base issues and their impact on the transatlantic defense market. Before joining CSIS, he worked as a freelance defense

Extended space expectation values in quantum dynamical system evolutions

DOE Office of Scientific and Technical Information (OSTI.GOV)

Demiralp, Metin

2014-10-06

The time variant power series expansion for the expectation value of a given quantum dynamical operator is well-known and well-investigated issue in quantum dynamics. However, depending on the operator and Hamiltonian singularities this expansion either may not exist or may not converge for all time instances except the beginning of the evolution. This work focuses on this issue and seeks certain cures for the negativities. We work in the extended space obtained by adding all images of the initial wave function under the system Hamiltonian’s positive integer powers. This requires the introduction of certain appropriately defined weight operators. The resultingmore » better convergence in the temporal power series urges us to call the new defined entities “extended space expectation values” even though they are constructed over certain weight operators and are somehow pseudo expectation values.« less

76 FR 53119 - Defense Logistics Agency Revised Regulation 1000.22, Environmental Considerations in Defense...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-25

... DEPARTMENT OF DEFENSE Office of the Secretary [Docket ID: DOD-2011-OS-0055] Defense Logistics Agency Revised Regulation 1000.22, Environmental Considerations in Defense Logistics Agency Actions AGENCY: Defense Logistics Agency, Department of Defense. ACTION: Comment Addressed on Notice of...

76 FR 28757 - Defense Logistics Agency Revised Regulation 1000.22, Environmental Considerations in Defense...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-18

... DEPARTMENT OF DEFENSE Office of the Secretary [DOCKET ID DOD-2011-OS-0055] Defense Logistics Agency Revised Regulation 1000.22, Environmental Considerations in Defense Logistics Agency Actions AGENCY: Defense Logistics Agency, Department of Defense. ACTION: Notice of Availability (NOA) of Revised...

Peptidoglycan from Fermentation By-Product Triggers Defense Responses in Grapevine

PubMed Central

Chen, Yang; Takeda, Taito; Aoki, Yoshinao; Fujita, Keiko; Suzuki, Shunji; Igarashi, Daisuke

2014-01-01

Plants are constantly under attack from a variety of microorganisms, and rely on a series of complex detection and response systems to protect themselves from infection. Here, we found that a by-product of glutamate fermentation triggered defense responses in grapevine, increasing the expression of defense response genes in cultured cells, foliar chitinase activity, and resistance to infection by downy mildew in leaf explants. To identify the molecule that triggered this innate immunity, we fractionated and purified candidates extracted from Corynebacterium glutamicum, a bacterium used in the production of amino acids by fermentation. Using hydrolysis by lysozyme, a silkworm larva plasma detection system, and gel filtration analysis, we identified peptidoglycan as inducing the defense responses. Peptidoglycans of Escherichia coli, Bacillus subtilis, and Staphylococcus aureus also generated similar defensive responses. PMID:25427192

75 FR 76423 - Defense Intelligence Agency National Defense Intelligence College Board of Visitors Closed Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-08

... DEPARTMENT OF DEFENSE Office of the Secretary Defense Intelligence Agency National Defense Intelligence College Board of Visitors Closed Meeting AGENCY: National Defense Intelligence College, Defense Intelligence Agency, Department of Defense. ACTION: Notice of Closed Meeting. SUMMARY: Pursuant to the...

76 FR 28960 - Defense Intelligence Agency National Defense Intelligence College Board of Visitors Closed Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-19

... DEPARTMENT OF DEFENSE Office of the Secretary Defense Intelligence Agency National Defense Intelligence College Board of Visitors Closed Meeting AGENCY: National Defense Intelligence College, Defense Intelligence Agency, Department of Defense. ACTION: Notice of Closed Meeting. SUMMARY: Pursuant to the...

Modeling of high-fidelity synthetic imagery for defense applications

NASA Astrophysics Data System (ADS)

Filbee, David R.; Kirk, Albert; Stroud, Colin A.; Hutchings, G.; Ward, T.; Brunnen, D.

2002-08-01

Within the military environment there is a growing interest in the use of synthetic imagery as a method for assessing the performance potential of many assets, such as camouflage systems, ATR/I systems, future sensor systems and the susceptibility of such systems to countermeasures. Field trials are expensive, subject to the vagaries of weather, and cannot be used to design or assess new systems and technologies. The requirements for high fidelity synthetic image simulation differ quite significantly dependent on the application area. The Camouflage Electro-Optic Simulation System (CAMEO-SIM) has been developed as a modular system to deliver 0.4-20 micron2 32-bit physics based synthetic imagery to defense researchers in the UK based on a 3D textured geometric representation of the synthetic environment. The system has been developed to be sufficiently flexible to support a wide range of defense applications requiring synthetic image streams as their inputs. The key difference between the CAMEO-SIM system and commercial image generation systems is that CAMEO-SIM is a first principle simulator working in spectral radiometric space solving the underlying physical equations of radiation transport. This difference underpins the military usefulness of the system and also enables the system to become predictive in nature. Using CAMEO-SIM, the user can examine the effects of changes in input parameters such as time of day, weather, material properties (optical and thermophysical), and wavelength from one set of geometric and textural information to assess the effects on the performance of the defense function being researched. If this goal can be achieved more robust defense function performance, due to larger available training sets or better understanding of the issues at the start of the development, will ensue. This paper outlines the development status of the CAMEO-SIM system and describes the current enhancements undertaken to improve the fidelity and accuracy of the

Defense Acquisitions: How DOD Acquires Weapon Systems and Recent Efforts to Reform the Process

DTIC Science & Technology

2010-04-23

Departments; the Chairman, Joint Chiefs of Staff (CJCS) and Joint Staff; the Unified Combatant Commands ( UCCs ); the Defense Agencies; and DOD field...Systems Congressional Research Service 24 industrialists in their own states and districts got their fair share , or more, of the military contracts...be a market for its products as a catalyst; this market was born when the comparatively small and unsophisticated U.S. peacetime ‘militia’ envisioned

Defense Human Resources Activity > PERSEREC

Science.gov Websites

Skip to main content (Press Enter). Toggle navigation Defense Human Resources Activity Search Search Defense Human Resources Activity: Search Search Defense Human Resources Activity: Search Defense Human Resources Activity U.S. Department of Defense Defense Human Resources Activity Overview

From Threat to Fear: The neural organization of defensive fear systems in humans

PubMed Central

Mobbs, Dean; Marchant, Jennifer L; Hassabis, Demis; Seymour, Ben; Tan, Geoffrey; Gray, Marcus; Petrovic, Predrag; Dolan, Raymond J.; Frith, Christopher D.

2009-01-01

Post-encounter and circa-strike defensive contexts represent two adaptive responses to potential and imminent danger. In the context of a predator, the post-encounter reflects the initial detection of the potential threat, whilst the circa-strike is associated with direct predatory attack. We used fMRI to investigate the neural organization of anticipation and avoidance of artificial predators with high or low probability of capturing the subject across analogous post-encounter and circa-strike contexts of threat. Consistent with defense systems models, post-encounter threat elicited activity in forebrain areas including subgenual anterior cingulate cortex (sgACC), hippocampus and amygdala. Conversely, active avoidance during circa-strike threat increased activity in mid-dorsal ACC and midbrain areas. During the circa-strike condition, subjects showed increased coupling between the midbrain and mid-dorsal ACC and decreased coupling with the sgACC, amygdala and hippocampus. Greater activity was observed in the right pregenual ACC for high compared to low probability of capture during circa-strike threat. This region showed decreased coupling with the amygdala, insula and ventromedial prefrontal cortex. Finally, we found that locomotor errors correlated with subjective reports of panic for the high compared to low probability of capture during the circa-strike threat and these panic-related locomotor errors were correlated with midbrain activity. These findings support models suggesting that higher forebrain areas are involved in early threat responses, including the assignment and control of fear, whereas as imminent danger results in fast, likely “hard-wired”, defensive reactions mediated by the midbrain. PMID:19793982

Civil Defense, U. S. A.: A Programmed Orientation to Civil Defense. Unit 5. Governmental Responsibilities for Civil Defense.

ERIC Educational Resources Information Center

Defense Civil Preparedness Agency (DOD), Battle Creek, MI.

A description of the laws and orders that provide necessary legal authorization for civil defense activities is provided. In addition, an outline of the responsibilities of all governments and the role of the private sector in civil defense is presented. Topics discussed include: (1) Legal authority for civil defense, (2) Civil defense…

32 CFR Appendix A to Part 77 - DD Form 2580, Operation Transition Department of Defense

Code of Federal Regulations, 2011 CFR

2011-07-01

... 32 National Defense 1 2011-07-01 2011-07-01 false DD Form 2580, Operation Transition Department of Defense A Appendix A to Part 77 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE... to Part 77—DD Form 2580, Operation Transition Department of Defense Outplacement and Referral System...

32 CFR Appendix A to Part 77 - DD Form 2580, Operation Transition Department of Defense

Code of Federal Regulations, 2010 CFR

2010-07-01

... 32 National Defense 1 2010-07-01 2010-07-01 false DD Form 2580, Operation Transition Department of Defense A Appendix A to Part 77 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE... to Part 77—DD Form 2580, Operation Transition Department of Defense Outplacement and Referral System...

32 CFR Appendix A to Part 77 - DD Form 2580, Operation Transition Department of Defense

Code of Federal Regulations, 2012 CFR

2012-07-01

... 32 National Defense 1 2012-07-01 2012-07-01 false DD Form 2580, Operation Transition Department of Defense A Appendix A to Part 77 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE... to Part 77—DD Form 2580, Operation Transition Department of Defense Outplacement and Referral System...

32 CFR Appendix A to Part 77 - DD Form 2580, Operation Transition Department of Defense

Code of Federal Regulations, 2013 CFR

2013-07-01

... 32 National Defense 1 2013-07-01 2013-07-01 false DD Form 2580, Operation Transition Department of Defense A Appendix A to Part 77 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE... to Part 77—DD Form 2580, Operation Transition Department of Defense Outplacement and Referral System...

32 CFR Appendix A to Part 77 - DD Form 2580, Operation Transition Department of Defense

Code of Federal Regulations, 2014 CFR

2014-07-01

... 32 National Defense 1 2014-07-01 2014-07-01 false DD Form 2580, Operation Transition Department of Defense A Appendix A to Part 77 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE... to Part 77—DD Form 2580, Operation Transition Department of Defense Outplacement and Referral System...

75 FR 52732 - Renewal of Department of Defense Federal Advisory Committee; Missile Defense Advisory Committee

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-27

... DEPARTMENT OF DEFENSE Office of the Secretary Renewal of Department of Defense Federal Advisory Committee; Missile Defense Advisory Committee AGENCY: Department of Defense (DoD). ACTION: Renewal of..., the Department of Defense gives notice that it is renewing the charter for the Missile Defense...

Acquiring Defense Systems: A Quest for the Best.

DTIC Science & Technology

1993-07-01

Chapter 7 The Political Character of Defense Policy -Making .............. 75 PART TWO INCEPTION OF AN ORGANIZED MANAGEMENT APPROACH Chapter 8 A Historical...175 Chapter 43 Total Package Procurement Discontinued .................... 177 PART SIX DECADE OF THE SEVENTIES Chapter 44 Policy Documents...DOD Actions ....................... 193 Chapter 49 Acquisition Advisory Group Report ........................ 195 Chapter 50 Profit Policy

Evaluating Moving Target Defense with PLADD

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jones, Stephen T.; Outkin, Alexander V.; Gearhart, Jared Lee

This project evaluates the effectiveness of moving target defense (MTD) techniques using a new game we have designed, called PLADD, inspired by the game FlipIt [28]. PLADD extends FlipIt by incorporating what we believe are key MTD concepts. We have analyzed PLADD and proven the existence of a defender strategy that pushes a rational attacker out of the game, demonstrated how limited the strategies available to an attacker are in PLADD, and derived analytic expressions for the expected utility of the game’s players in multiple game variants. We have created an algorithm for finding a defender’s optimal PLADD strategy. Wemore » show that in the special case of achieving deterrence in PLADD, MTD is not always cost effective and that its optimal deployment may shift abruptly from not using MTD at all to using it as aggressively as possible. We believe our effort provides basic, fundamental insights into the use of MTD, but conclude that a truly practical analysis requires model selection and calibration based on real scenarios and empirical data. We propose several avenues for further inquiry, including (1) agents with adaptive capabilities more reflective of real world adversaries, (2) the presence of multiple, heterogeneous adversaries, (3) computational game theory-based approaches such as coevolution to allow scaling to the real world beyond the limitations of analytical analysis and classical game theory, (4) mapping the game to real-world scenarios, (5) taking player risk into account when designing a strategy (in addition to expected payoff), (6) improving our understanding of the dynamic nature of MTD-inspired games by using a martingale representation, defensive forecasting, and techniques from signal processing, and (7) using adversarial games to develop inherently resilient cyber systems.« less

A knowledge based application of the extended aircraft interrogation and display system

NASA Technical Reports Server (NTRS)

Glover, Richard D.; Larson, Richard R.

1991-01-01

A family of multiple-processor ground support test equipment was used to test digital flight-control systems on high-performance research aircraft. A unit recently built for the F-18 high alpha research vehicle project is the latest model in a series called the extended aircraft interrogation and display system. The primary feature emphasized monitors the aircraft MIL-STD-1553B data buses and provides real-time engineering units displays of flight-control parameters. A customized software package was developed to provide real-time data interpretation based on rules embodied in a highly structured knowledge database. The configuration of this extended aircraft interrogation and display system is briefly described, and the evolution of the rule based package and its application to failure modes and effects testing on the F-18 high alpha research vehicle is discussed.

Fuel cell powered small unmanned aerial systems (UASs) for extended endurance flights

NASA Astrophysics Data System (ADS)

Chu, Deryn; Jiang, R.; Dunbar, Z.; Grew, Kyle; McClure, J.

2015-05-01

Small unmanned aerial systems (UASs) have been used for military applications and have additional potential for commercial applications [1-4]. For the military, these systems provide valuable intelligence, surveillance, reconnaissance and target acquisition (ISRTA) capabilities for units at the infantry, battalion, and company levels. The small UASs are light-weight, manportable, can be hand-launched, and are capable of carrying payloads. Currently, most small UASs are powered by lithium-ion or lithium polymer batteries; however, the flight endurance is usually limited less than two hours and requires frequent battery replacement. Long endurance small UAS flights have been demonstrated through the implementation of a fuel cell system. For instance, a propane fueled solid oxide fuel cell (SOFC) stack has been used to power a small UAS and shown to extend mission flight time. The research and development efforts presented here not only apply to small UASs, but also provide merit to the viability of extending mission operations for other unmanned systems applications.

75 FR 51416 - Defense Federal Acquisition Regulation Supplement; Acquisition of Commercial Items

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-20

... be used for the acquisition of commercial items, and revised the language to address the conditions... DEPARTMENT OF DEFENSE Defense Acquisition Regulations System 48 CFR Parts 202, 212, and 234 [DFARS Case 2008-D011] Defense Federal Acquisition Regulation Supplement; Acquisition of Commercial Items...

77 FR 74177 - Information Collection Requirement; Defense Federal Acquisition Regulation Supplement; Production...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-13

... DEPARTMENT OF DEFENSE Defense Acquisition Regulations System [Docket No. DARS 2012-0044-0001..., Department of Defense (DoD). ACTION: Notice; request for comments regarding a proposed extension of an [[Page... identify any factors that may delay performance. The Government relies on the production progress reports...

Radiological Defense. Textbook.

ERIC Educational Resources Information Center

Defense Civil Preparedness Agency (DOD), Washington, DC.

This textbook has been prepared under the direction of the Defense Civil Preparedness Agency (DCPA) Staff College for use as a student reference manual in radiological defense (RADEF) courses. It provides much of the basic technical information necessary for a proper understanding of radiological defense and summarizes RADEF planning and expected…

76 FR 71823 - Defense Federal Acquisition Regulation Supplement: Responsibility and Liability for Government...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-18

... Vol. 76 Friday, No. 223 November 18, 2011 Part V Department of Defense Defense Acquisition Regulation System 48 CFR Parts 202, 203, 211, et al. Defense Federal Acquisition Regulation Supplements... Regulations#0;#0; [[Page 71824

Department of Defense, Department of the Navy FY 1994 Budget Estimates, Report on Information Technology Systems

DTIC Science & Technology

1993-04-01

3,822 2,076 0 Exhibit 43A-Za Page 71 of 77 DEPARTMENT OF DEFENSE Department of the Navy FY 1994 Budget Estimates Exhibit 43A-2a Report on Operations...Contracts: Martin Marietta , Information Systems Group is the systems integrator with principle subcontractors of Hewlett. Packard and Racal-Milgo...DEPARTMENT OF PEFENSE April 1993 Department of the Navy FY 1994 Budget Estimates Report on Information Technology Systmm INDEX E xh bi-t tl

Civil Defense, U. S. A.: A Programmed Orientation to Civil Defense. Unit 1. Civil Defense - Protection Against What?

ERIC Educational Resources Information Center

Defense Civil Preparedness Agency (DOD), Battle Creek, MI.

An explanation of the need for civil defense in nuclear and natural disasters is presented. A brief historical background of civil defense is given. Major topics include: (1) Types of disasters, (2) Probable objectives of a nuclear attack on the United States, (3) The major defensive measures against a nuclear attack, (4) Some reasons for low…

Self-reported attachment patterns and Rorschach-related scores of ego boundary, defensive processes, and thinking disorders.

PubMed

Berant, Ety; Wald, Yaarit

2009-07-01

In this study, we addressed associations between self-reported attachment scales (anxiety and avoidance) and Rorschach (1921/1942) indexes indicating ego-boundary perception (barrier and penetration), use of projective identification, devaluation and splitting defenses, and Comprehensive System (Exner, 2005) scores that represent boundary blurring (incongruous and fabulized combinations). In this study, we extended the sample and findings described by Berant, Mikulincer, Shaver, and Segal (2005) using a nonclinical sample of 89 Israeli adults. We found significant associations between attachment orientations and Rorschach indexes dynamically related to anxiety. We also found a trend toward association between attachment orientation and avoidance. We discuss the theoretical and clinical implications of these findings.

Physics of a ballistic missile defense - The chemical laser boost-phase defense

NASA Technical Reports Server (NTRS)

Grabbe, Crockett L.

1988-01-01

The basic physics involved in proposals to use a chemical laser based on satellites for a boost-phase defense are investigated. After a brief consideration of simple physical conditions for the defense, a calculation of an equation for the number of satellites needed for the defense is made along with some typical values of this for possible future conditions for the defense. Basic energy and power requirements for the defense are determined. A sumary is made of probable minimum conditions that must be achieved for laser power, targeting accuracy, number of satellites, and total sources for power needed.

Defense.gov - Special Report

Science.gov Websites

FORUM - U.S. Defense Secretary Robert M. Gates addresses the audience as Canadian Minister of National issues that Defense Secretary Robert M. Gates and Canadian Defense Minister Peter MacKay discussed during a bilateral meeting here today. Story | Transcript U.S., Canadian Defense Chiefs Answer Afghanistan

Strategy alternatives for homeland air and cruise missile defense.

PubMed

Murphy, Eric M; Payne, Michael D; Vanderwoude, Glenn W

2010-10-01

Air and cruise missile defense of the U.S. homeland is characterized by a requirement to protect a large number of critical assets nonuniformly dispersed over a vast area with relatively few defensive systems. In this article, we explore strategy alternatives to make the best use of existing defense resources and suggest this approach as a means of reducing risk while mitigating the cost of developing and acquiring new systems. We frame the issue as an attacker-defender problem with simultaneous moves. First, we outline and examine the relatively simple problem of defending comparatively few locations with two surveillance systems. Second, we present our analysis and findings for a more realistic scenario that includes a representative list of U.S. critical assets. Third, we investigate sensitivity to defensive strategic choices in the more realistic scenario. As part of this investigation, we describe two complementary computational methods that, under certain circumstances, allow one to reduce large computational problems to a more manageable size. Finally, we demonstrate that strategic choices can be an important supplement to material solutions and can, in some cases, be a more cost-effective alternative. © 2010 Society for Risk Analysis.

Extended spider cognition.

PubMed

Japyassú, Hilton F; Laland, Kevin N

2017-05-01

There is a tension between the conception of cognition as a central nervous system (CNS) process and a view of cognition as extending towards the body or the contiguous environment. The centralised conception requires large or complex nervous systems to cope with complex environments. Conversely, the extended conception involves the outsourcing of information processing to the body or environment, thus making fewer demands on the processing power of the CNS. The evolution of extended cognition should be particularly favoured among small, generalist predators such as spiders, and here, we review the literature to evaluate the fit of empirical data with these contrasting models of cognition. Spiders do not seem to be cognitively limited, displaying a large diversity of learning processes, from habituation to contextual learning, including a sense of numerosity. To tease apart the central from the extended cognition, we apply the mutual manipulability criterion, testing the existence of reciprocal causal links between the putative elements of the system. We conclude that the web threads and configurations are integral parts of the cognitive systems. The extension of cognition to the web helps to explain some puzzling features of spider behaviour and seems to promote evolvability within the group, enhancing innovation through cognitive connectivity to variable habitat features. Graded changes in relative brain size could also be explained by outsourcing information processing to environmental features. More generally, niche-constructed structures emerge as prime candidates for extending animal cognition, generating the selective pressures that help to shape the evolving cognitive system.

The Host Defense Proteome of Human and Bovine Milk

PubMed Central

Hettinga, Kasper; van Valenberg, Hein; de Vries, Sacco; Boeren, Sjef; van Hooijdonk, Toon; van Arendonk, Johan; Vervoort, Jacques

2011-01-01

Milk is the single source of nutrients for the newborn mammal. The composition of milk of different mammals has been adapted during evolution of the species to fulfill the needs of the offspring. Milk not only provides nutrients, but it also serves as a medium for transfer of host defense components to the offspring. The host defense proteins in the milk of different mammalian species are expected to reveal signatures of evolution. The aim of this study is therefore to study the difference in the host defense proteome of human and bovine milk. We analyzed human and bovine milk using a shot-gun proteomics approach focusing on host defense-related proteins. In total, 268 proteins in human milk and 269 proteins in bovine milk were identified. Of these, 44 from human milk and 51 from bovine milk are related to the host defense system. Of these proteins, 33 were found in both species but with significantly different quantities. High concentrations of proteins involved in the mucosal immune system, immunoglobulin A, CD14, lactoferrin, and lysozyme, were present in human milk. The human newborn is known to be deficient for at least two of these proteins (immunoglobulin A and CD14). On the other hand, antimicrobial proteins (5 cathelicidins and lactoperoxidase) were abundant in bovine milk. The high concentration of lactoperoxidase is probably linked to the high amount of thiocyanate in the plant-based diet of cows. This first detailed analysis of host defense proteins in human and bovine milk is an important step in understanding the function of milk in the development of the immune system of these two mammals. PMID:21556375

An analytical approach to air defense: cost, effectiveness and SWOT analysis of employing fighter aircraft and modern SAM systems

NASA Astrophysics Data System (ADS)

Kus, Orcun; Kocaman, Ibrahim; Topcu, Yucel; Karaca, Volkan

2012-05-01

The problem of defending a specific airspace is among the main issues a military commander to solve. Proper protection of own airspace is crucial for mission success at the battlefield. The military doctrines of most world armed forces involve two main options of defending the airspace. One of them is utilizing formations of fighter aircraft, which is a flexible choice. The second option is deploying modern SAM (Surface to Air Missile) systems, which is more expansive. On the other hand the decision makers are to cope with miscellaneous restrictions such as the budgeting problems. This study defines air defense concept according to modern air warfare doctrine. It considers an air defense scenario over an arbitrary airspace and compares the performance and cost-effectiveness of employing fighter aircraft and SAM systems. It also presents SWOT (Strenghts - Weakness - Opportunities - Threats) analyses of air defense by fighter aircraft and by modern SAMs and tries to point out whichever option is better. We conclude that deploying SAMs has important advantages over using fighter aircraft by means of interception capacity within a given time period and is cost-effective.

Concepts. The Journal of Defense Systems Acquisition Management. Winter 1981. Volume 4. Number 1.

DTIC Science & Technology

1981-01-01

Long, USAF A major challenge facing the program manager is to effectively obtain and manage program funds. It is the author’s view that too few...Henry H. Mendenhall As defense systems become more and more complex, an effective test and evaluation program becomes more and more necessary. This means...that lies ahead for the military acquisition manager. And let us not think for a moment that optimism alone will suffice. Good, effective , efficient

Extended Range Intercept Technology

DTIC Science & Technology

1991-09-01

particle size other than Freon class fluids. The requirements for a solvent used in grinding ammonium perchlorate to a one micron particle size are high...demonstrate a preprototype missile and launch control systems technology for tactical missile defense applications, including performance ...these two flights would be to verify flight performance and stability of the basic air frame and control system design (LTV Missiles and 1 -2 wp«-2a

Systemic acquired resistance in moss: further evidence for conserved defense mechanisms in plants.

PubMed

Winter, Peter S; Bowman, Collin E; Villani, Philip J; Dolan, Thomas E; Hauck, Nathanael R

2014-01-01

Vascular plants possess multiple mechanisms for defending themselves against pathogens. One well-characterized defense mechanism is systemic acquired resistance (SAR). In SAR, a plant detects the presence of a pathogen and transmits a signal throughout the plant, inducing changes in the expression of various pathogenesis-related (PR) genes. Once SAR is established, the plant is capable of mounting rapid responses to subsequent pathogen attacks. SAR has been characterized in numerous angiosperm and gymnosperm species; however, despite several pieces of evidence suggesting SAR may also exist in non-vascular plants6-8, its presence in non-vascular plants has not been conclusively demonstrated, in part due to the lack of an appropriate culture system. Here, we describe and use a novel culture system to demonstrate that the moss species Amblystegium serpens does initiate a SAR-like reaction upon inoculation with Pythium irregulare, a common soil-borne oomycete. Infection of A. serpens gametophores by P. irregulare is characterized by localized cytoplasmic shrinkage within 34 h and chlorosis and necrosis within 7 d of inoculation. Within 24 h of a primary inoculation (induction), moss gametophores grown in culture became highly resistant to infection following subsequent inoculation (challenge) by the same pathogen. This increased resistance was a response to the pathogen itself and not to physical wounding. Treatment with β-1,3 glucan, a structural component of oomycete cell walls, was equally effective at triggering SAR. Our results demonstrate, for the first time, that this important defense mechanism exists in a non-vascular plant, and, together with previous studies, suggest that SAR arose prior to the divergence of vascular and non-vascular plants. In addition, this novel moss - pathogen culture system will be valuable for future characterization of the mechanism of SAR in moss, which is necessary for a better understanding of the evolutionary history of SAR in

48 CFR 652.228-71 - Worker's Compensation Insurance (Defense Base Act)-Services.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Insurance (Defense Base Act)-Services. 652.228-71 Section 652.228-71 Federal Acquisition Regulations System... Clauses 652.228-71 Worker's Compensation Insurance (Defense Base Act)—Services. As prescribed in 628.309-70(b), insert the following clause: Workers' Compensation Insurance (Defense Base Act)—Services (JUN...

48 CFR 652.228-71 - Worker's Compensation Insurance (Defense Base Act)-Services.

Code of Federal Regulations, 2013 CFR

2013-10-01

... Insurance (Defense Base Act)-Services. 652.228-71 Section 652.228-71 Federal Acquisition Regulations System... Clauses 652.228-71 Worker's Compensation Insurance (Defense Base Act)—Services. As prescribed in 628.309-70(b), insert the following clause: Workers' Compensation Insurance (Defense Base Act)—Services (JUN...

48 CFR 652.228-71 - Worker's Compensation Insurance (Defense Base Act)-Services.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Insurance (Defense Base Act)-Services. 652.228-71 Section 652.228-71 Federal Acquisition Regulations System... Clauses 652.228-71 Worker's Compensation Insurance (Defense Base Act)—Services. As prescribed in 628.309-70(b), insert the following clause: Workers' Compensation Insurance (Defense Base Act)—Services (JUN...

48 CFR 652.228-71 - Worker's Compensation Insurance (Defense Base Act)-Services.

Code of Federal Regulations, 2014 CFR

2014-10-01

... Insurance (Defense Base Act)-Services. 652.228-71 Section 652.228-71 Federal Acquisition Regulations System... Clauses 652.228-71 Worker's Compensation Insurance (Defense Base Act)—Services. As prescribed in 628.309-70(b), insert the following clause: Workers' Compensation Insurance (Defense Base Act)—Services (JUN...

48 CFR 652.228-71 - Worker's Compensation Insurance (Defense Base Act)-Services.

Code of Federal Regulations, 2012 CFR

2012-10-01

... Insurance (Defense Base Act)-Services. 652.228-71 Section 652.228-71 Federal Acquisition Regulations System... Clauses 652.228-71 Worker's Compensation Insurance (Defense Base Act)—Services. As prescribed in 628.309-70(b), insert the following clause: Workers' Compensation Insurance (Defense Base Act)—Services (JUN...

Seeking Defense Efficiency

DTIC Science & Technology

2001-01-01

improving defense management requires decentralizing the pursuit of efficiency on a framework of strategic planning, cost accounting , and performance...Office (GAO) report (1999) questions whether assumed sav- ings figures may be overly optimistic in not sufficiently accounting for the costs of...inputs�.� money and personnel spaces from opera- tions and maintenance (O&M) budget lines? Without better systems to account for costs and to measure

Host-pathogen interactions between the human innate immune system and Candida albicans—understanding and modeling defense and evasion strategies

PubMed Central

Dühring, Sybille; Germerodt, Sebastian; Skerka, Christine; Zipfel, Peter F.; Dandekar, Thomas; Schuster, Stefan

2015-01-01

The diploid, polymorphic yeast Candida albicans is one of the most important human pathogenic fungi. C. albicans can grow, proliferate and coexist as a commensal on or within the human host for a long time. However, alterations in the host environment can render C. albicans virulent. In this review, we describe the immunological cross-talk between C. albicans and the human innate immune system. We give an overview in form of pairs of human defense strategies including immunological mechanisms as well as general stressors such as nutrient limitation, pH, fever etc. and the corresponding fungal response and evasion mechanisms. Furthermore, Computational Systems Biology approaches to model and investigate these complex interactions are highlighted with a special focus on game-theoretical methods and agent-based models. An outlook on interesting questions to be tackled by Systems Biology regarding entangled defense and evasion mechanisms is given. PMID:26175718

Long-range analysis of density fitting in extended systems

NASA Astrophysics Data System (ADS)

Varga, Scarontefan

Density fitting scheme is analyzed for the Coulomb problem in extended systems from the correctness of long-range behavior point of view. We show that for the correct cancellation of divergent long-range Coulomb terms it is crucial for the density fitting scheme to reproduce the overlap matrix exactly. It is demonstrated that from all possible fitting metric choices the Coulomb metric is the only one which inherently preserves the overlap matrix for infinite systems with translational periodicity. Moreover, we show that by a small additional effort any non-Coulomb metric fit can be made overlap-preserving as well. The problem is analyzed for both ordinary and Poisson basis set choices.

Pathological anxiety and function/dysfunction in the brain's fear/defense circuitry.

PubMed

Lang, Peter J; McTeague, Lisa M; Bradley, Margaret M

2014-01-01

Research from the University of Florida Center for the Study of Emotion and Attention aims to develop neurobiological measures that objectively discriminate among symptom patterns in patients with anxiety disorders. From this perspective, anxiety and mood pathologies are considered to be brain disorders, resulting from dysfunction and maladaptive plasticity in the neural circuits that determine fearful/defensive and appetitive/reward behavior (Insel et al., 2010). We review recent studies indicating that an enhanced probe startle reflex during the processing of fear memory cues (mediated by cortico-limbic circuitry and thus indicative of plastic brain changes), varies systematically in strength over a spectrum-wide dimension of anxiety pathology-across and within diagnoses-extending from strong focal fear reactions to a consistently blunted reaction in patients with more generalized anxiety and comorbid mood disorders. Preliminary studies with functional magnetic resonance imaging (fMRI) encourage the hypothesis that fear/defense circuit dysfunction covaries with this same dimension of psychopathology. Plans are described for an extended study of the brain's motivation circuitry in anxiety spectrum patients, with the aim of defining the specifics of circuit dysfunction in severe disorders. A sub-project explores the use of real-time fMRI feedback in circuit analysis and as a modality to up-regulate circuit function in the context of blunted affect.

Immune defense and host life history.

PubMed

Zuk, Marlene; Stoehr, Andrew M

2002-10-01

Recent interest has focused on immune response in an evolutionary context, with particular attention to disease resistance as a life-history trait, subject to trade-offs against other traits such as reproductive effort. Immune defense has several characteristics that complicate this approach, however; for example, because of the risk of autoimmunity, optimal immune defense is not necessarily maximum immune defense. Two important types of cost associated with immunity in the context of life history are resource costs, those related to the allocation of essential but limited resources, such as energy or nutrients, and option costs, those paid not in the currency of resources but in functional or structural components of the organism. Resource and option costs are likely to apply to different aspects of resistance. Recent investigations into possible trade-offs between reproductive effort, particularly sexual displays, and immunity have suggested interesting functional links between the two. Although all organisms balance the costs of immune defense against the requirements of reproduction, this balance works out differently for males than it does for females, creating sex differences in immune response that in turn are related to ecological factors such as the mating system. We conclude that immune response is indeed costly and that future work would do well to include invertebrates, which have sometimes been neglected in studies of the ecology of immune defense.

RNA-Seq identification of candidate defense genes targeted by endophytic Bacillus cereus-mediated induced systemic resistance against Meloidogyne incognita in tomato.

PubMed

Hu, Haijing; Wang, Cong; Li, Xia; Tang, Yunyun; Wang, Yufang; Chen, Shuanglin; Yan, Shuzhen

2018-05-08

The endophytic bacteria Bacillus cereus BCM2 has shown great potential as a defense against the parasitic nematode Meloidogyne incognita. Here, we studied the endophytic bacteria-mediated plant defense against M. incognita and searched for defense-related candidate genes using RNA-Seq. The induced systemic resistance of BCM2 against M. incognita was tested using the split-root method. Pre-inoculated BCM2 on the inducer side was associated with a dramatic reduction in galls and egg masses at the responder side, but inoculated BCM2 alone did not produce the same effect. In order to investigate which plant defense-related genes are specifically activated by BCM2, four RNA samples from tomato roots were sequenced, and four high quality total clean bases were obtained, ranging from 6.64 to 6.75 Gb, with an average of 21558 total genes. The 34 candidate defense-related genes were identified by pair-wise comparison among libraries, representing the targets for BCM2 priming resistance against M. incognita. Functional characterization revealed that the plant-pathogen interaction pathway (ID: ko04626) was significantly enriched for BCM2-mediated M. incognita resistance. This study demonstrates that B. cereus BCM2 maintains a harmonious host-microbe relationship with tomato, but appeared to prime the plant, resulting in more vigorous defense response toward the infection nematode. This article is protected by copyright. All rights reserved.

Defense switched network technology and experiments program

NASA Astrophysics Data System (ADS)

Weinstein, C. J.

1983-09-01

This report documents work performed during FY 1983 on the DCA-sponsored Defense Switched Network Technology and Experiments Program. The areas of work reported are: (1) development of routing algorithms for application in the Defense Switched Network (DSN); (2) instrumentation and integration of the Experimental Integrated Switched Network (EISN) test facility; (3) development and test of data communication techniques using DoD-standard data protocols in an integrated voice/data network; and (4) EISN system coordination and experiment planning.

Discrete Event Simulation of a Suppression of Enemy Air Defenses (SEAD) Mission

DTIC Science & Technology

2008-03-01

component-based DES developed in Java® using the Simkit simulation package. Analysis of ship self air defense system selection ( Turan , 1999) is another...Institute of Technology, Wright-Patterson AFB OH, March 2003 (ADA445279 ) Turan , Bulent. A Comparative Analysis of Ship Self Air Defense (SSAD) Systems

Extending Team Software Process (TSP) to Systems Engineering: A NAVAIR Experience Report

DTIC Science & Technology

2010-03-01

instrumental in formulating the concepts and approaches presented in this report: Dan Burton, Anita Carleton, Timothy Chick, Mike Fehring, Watts Humphrey ...Senate,” GAO-04-393, Defense Acquisitions, 2004. http://www.gao.gov/new.items/d04393.pdf [ Humphrey 06] W. S . Humphrey , TSP: Leading a Development... Humphrey 08] W. S . Humphrey , “The Process Revolution,” CrossTalk The Journal of Defense Software Engineering, August 2008, Volume 28 Number 8

77 FR 52252 - Defense Federal Acquisition Regulation Supplement: Inflation Adjustment of Threshold for...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-29

... DEPARTMENT OF DEFENSE Defense Acquisition Regulations System 48 CFR Parts 201 and 212 RIN 0750-AH65 Defense Federal Acquisition Regulation Supplement: Inflation Adjustment of Threshold for... respondent concurred with the inflation threshold increase listed at DFARS 212.271. There were no comments...

A Systems Engineering Approach in Providing Air Defense Support to Ground Combat Vehicle Maneuver Forces

DTIC Science & Technology

2015-03-01

Defense DODAF Department of Defense Architecture Framework DOE design of experiment EMMI energy , mass, material wealth, information FNF fire and... energy or blast power (depending on the type of projectile). Tank munitions have significant penetrative ability and can cause serious damage to...survivability of ground combat vehicles during ground force maneuver operations. The simulation results indicated that the presence of air defense

The Impact of Emerging MEMS-Based Microsystems on US Defense Applications

DOE Office of Scientific and Technical Information (OSTI.GOV)

STAPLE,BEVAN D.; JAKUBCZAK II,JEROME F.

2000-01-20

This paper examines the impact of inserting Micro-Electro-Mechanical Systems (MEMS) into US defense applications. As specific examples, the impacts of micro Inertial Measurement Units (IMUs), radio frequency MEMS (RF MEMS), and Micro-Opto-Electro-Mechanical Systems (MOEMS) to provide integrated intelligence, communication, and control to the defense infrastructure with increased affordability, functionality, and performance are highlighted.

Defense AT&L Magazine: A Publication of the Defense Acquisition University. Volume 34, Number 3, DAU 184

DTIC Science & Technology

2005-01-01

developed a partnership with the Defense Acquisition University to in- tegrate DISA’s systems engineering processes, software , and network...in place, with processes being implemented: deployment management; systems engineering ; software engineering ; configuration man- agement; test and...CSS systems engineering is a transition partner with Carnegie Mellon University’s Software Engineering Insti- tute and its work on the capability

The Effectiveness of Concurrent Design on the Cost and Schedule Performance of Defense Weapons System Acquisitions

NASA Astrophysics Data System (ADS)

Robertson, Randolph B.

This study investigates the impact of concurrent design on the cost growth and schedule growth of US Department of Defense Major Defense Acquisition Systems (MDAPs). It is motivated by the question of whether employment of concurrent design in the development of a major weapon system will produce better results in terms of cost and schedule than traditional serial development methods. Selected Acquisition Reports were used to determine the cost and schedule growth of MDAPs as well as the degree of concurrency employed. Two simple linear regression analyses were used to determine the degree to which cost growth and schedule growth vary with concurrency. The results were somewhat surprising in that for major weapon systems the utilization of concurrency as it was implemented in the programs under study was shown to have no effect on cost performance, and that performance to development schedule, one of the purported benefits of concurrency, was actually shown to deteriorate with increases in concurrency. These results, while not an indictment of the concept of concurrency, indicate that better practices and methods are needed in the implementation of concurrency in major weapon systems. The findings are instructive to stakeholders in the weapons acquisition process in their consideration of whether and how to employ concurrent design strategies in their planning of new weapons acquisition programs.

75 FR 13093 - Renewal of Department of Defense Federal Advisory Committee; Defense Acquisition University Board...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-18

... DEPARTMENT OF DEFENSE Office of the Secretary Renewal of Department of Defense Federal Advisory Committee; Defense Acquisition University Board of Visitors AGENCY: Department of Defense (DoD). ACTION... (5 U.S.C. 552b, as amended), and 41 CFR 102-3.50(c), the Department of Defense gives notice that it...

Sliding mode control for a two-joint coupling nonlinear system based on extended state observer.

PubMed

Zhao, Ling; Cheng, Haiyan; Wang, Tao

2018-02-01

A two-joint coupling nonlinear system driven by pneumatic artificial muscles is introduced in this paper. A sliding mode controller with extended state observer is proposed to cope with nonlinearities and disturbances for the two-joint coupling nonlinear system. In addition, convergence of the extended state observer is presented and stability analysis of the closed-loop system is also demonstrated with the sliding mode controller. Lastly, some experiments are carried out to show the reality effectiveness of the proposed method. Copyright © 2018 ISA. Published by Elsevier Ltd. All rights reserved.

Demagnetization monitoring and life extending control for permanent magnet-driven traction systems

NASA Astrophysics Data System (ADS)

Niu, Gang; Liu, Senyi

2018-03-01

This paper presents a novel scheme of demagnetization monitoring and life extending control for traction systems driven by permanent magnet synchronous motors (PMSMs). Firstly, the offline training is carried to evaluate fatigue damage of insulated gate bipolar transistors (IGBTs) under different flux loss based on first-principle modeling. Then an optimal control law can be extracted by turning down the power distribution factor of the demagnetizing PMSM until all damages of IGBTs turn to balance. Next, the similarity-based empirical modeling is employed to online estimate remaining flux of PMSMs, which is used to update the power distribution factor by referring the optimal control law for the health-oriented autonomous control. The proposed strategy can be demonstrated by a case study of traction drive system coupled with dual-PMSMs. Compared with traditional control strategy, the results show that the novel scheme can not only guarantee traction performance but also extend remaining useful life (RUL) of the system after suffering demagnetization fault.

Avian host defense peptides.

PubMed

Cuperus, Tryntsje; Coorens, Maarten; van Dijk, Albert; Haagsman, Henk P

2013-11-01

Host defense peptides (HDPs) are important effector molecules of the innate immune system of vertebrates. These antimicrobial peptides are also present in invertebrates, plants and fungi. HDPs display broad-spectrum antimicrobial activities and fulfill an important role in the first line of defense of many organisms. It is becoming increasingly clear that in the animal kingdom the functions of HDPs are not confined to direct antimicrobial actions. Research in mammals has indicated that HDPs have many immunomodulatory functions and are also involved in other physiological processes ranging from development to wound healing. During the past five years our knowledge about avian HDPs has increased considerably. This review addresses our current knowledge on the evolution, regulation and biological functions of HDPs of birds. Copyright © 2013 Elsevier Ltd. All rights reserved.

Strategic Defense Initiative Organization adaptive structures program overview