High-Frequency Amplification and Sound Quality in Listeners with Normal through Moderate Hearing Loss

ERIC Educational Resources Information Center

Ricketts, Todd A.; Dittberner, Andrew B.; Johnson, Earl E.

2008-01-01

Purpose: One factor that has been shown to greatly affect sound quality is audible bandwidth. Provision of gain for frequencies above 4-6 kHz has not generally been supported for groups of hearing aid wearers. The purpose of this study was to determine if preference for bandwidth extension in hearing aid processed sounds was related to the…

Initial Determination of Low Earth Orbits Using Commercial Telescopes

DTIC Science & Technology

2008-03-01

many new technologies have significantly changed the face of private astronomy . Developments such as inexpensive but high-quality sensors, rapid... astronomy . Unpar- alleled access to quality equipment, rapid personal computing, and extensive community support enable nearly anyone to achieve feats in...other subdisciplines of astronomy , this field benefits greatly from recent advances. This project examines how modern equipment is used to track Low Earth

High quality atomically thin PtSe2 films grown by molecular beam epitaxy

NASA Astrophysics Data System (ADS)

Yan, Mingzhe; Wang, Eryin; Zhou, Xue; Zhang, Guangqi; Zhang, Hongyun; Zhang, Kenan; Yao, Wei; Lu, Nianpeng; Yang, Shuzhen; Wu, Shilong; Yoshikawa, Tomoki; Miyamoto, Koji; Okuda, Taichi; Wu, Yang; Yu, Pu; Duan, Wenhui; Zhou, Shuyun

2017-12-01

Atomically thin PtSe2 films have attracted extensive research interests for potential applications in high-speed electronics, spintronics and photodetectors. Obtaining high quality thin films with large size and controlled thickness is critical. Here we report the first successful epitaxial growth of high quality PtSe2 films by molecular beam epitaxy. Atomically thin films from 1 ML to 22 ML have been grown and characterized by low-energy electron diffraction, Raman spectroscopy and x-ray photoemission spectroscopy. Moreover, a systematic thickness dependent study of the electronic structure is revealed by angle-resolved photoemission spectroscopy (ARPES), and helical spin texture is revealed by spin-ARPES. Our work provides new opportunities for growing large size single crystalline films to investigate the physical properties and potential applications of PtSe2.

An Overview of NPP VIIRS Pre-Launch and On-Orbit Calibration and Characterization

NASA Technical Reports Server (NTRS)

Butler, Jim; Gleason, Jim; Xiong, Jack; Chang, Vincent; Lee, Shih Yan

2011-01-01

NPP Visible Infrared Imaging Radiometer Suite (VIIRS) test program at the instrument and observatory level is complete and has provided an extensive amount of high quality data to enable the assessment of sensor performance.

High-Alpha Handling Qualities Flight Research on the NASA F/A-18 High Alpha Research Vehicle

NASA Technical Reports Server (NTRS)

Wichman, Keith D.; Pahle, Joseph W.; Bahm, Catherine; Davidson, John B.; Bacon, Barton J.; Murphy, Patrick C.; Ostroff, Aaron J.; Hoffler, Keith D.

1996-01-01

A flight research study of high-angle-of-attack handling qualities has been conducted at the NASA Dryden Flight Research Center using the F/A-18 High Alpha Research Vehicle (HARV). The objectives were to create a high-angle-of-attack handling qualities flight database, develop appropriate research evaluation maneuvers, and evaluate high-angle-of-attack handling qualities guidelines and criteria. Using linear and nonlinear simulations and flight research data, the predictions from each criterion were compared with the pilot ratings and comments. Proposed high-angle-of-attack nonlinear design guidelines and proposed handling qualities criteria and guidelines developed using piloted simulation were considered. Recently formulated time-domain Neal-Smith guidelines were also considered for application to high-angle-of-attack maneuvering. Conventional envelope criteria were evaluated for possible extension to the high-angle-of-attack regime. Additionally, the maneuvers were studied as potential evaluation techniques, including a limited validation of the proposed standard evaluation maneuver set. This paper gives an overview of these research objectives through examples and summarizes result highlights. The maneuver development is described briefly, the criteria evaluation is emphasized with example results given, and a brief discussion of the database form and content is presented.

The Medical Imaging Interaction Toolkit: challenges and advances : 10 years of open-source development.

PubMed

Nolden, Marco; Zelzer, Sascha; Seitel, Alexander; Wald, Diana; Müller, Michael; Franz, Alfred M; Maleike, Daniel; Fangerau, Markus; Baumhauer, Matthias; Maier-Hein, Lena; Maier-Hein, Klaus H; Meinzer, Hans-Peter; Wolf, Ivo

2013-07-01

The Medical Imaging Interaction Toolkit (MITK) has been available as open-source software for almost 10 years now. In this period the requirements of software systems in the medical image processing domain have become increasingly complex. The aim of this paper is to show how MITK evolved into a software system that is able to cover all steps of a clinical workflow including data retrieval, image analysis, diagnosis, treatment planning, intervention support, and treatment control. MITK provides modularization and extensibility on different levels. In addition to the original toolkit, a module system, micro services for small, system-wide features, a service-oriented architecture based on the Open Services Gateway initiative (OSGi) standard, and an extensible and configurable application framework allow MITK to be used, extended and deployed as needed. A refined software process was implemented to deliver high-quality software, ease the fulfillment of regulatory requirements, and enable teamwork in mixed-competence teams. MITK has been applied by a worldwide community and integrated into a variety of solutions, either at the toolkit level or as an application framework with custom extensions. The MITK Workbench has been released as a highly extensible and customizable end-user application. Optional support for tool tracking, image-guided therapy, diffusion imaging as well as various external packages (e.g. CTK, DCMTK, OpenCV, SOFA, Python) is available. MITK has also been used in several FDA/CE-certified applications, which demonstrates the high-quality software and rigorous development process. MITK provides a versatile platform with a high degree of modularization and interoperability and is well suited to meet the challenging tasks of today's and tomorrow's clinically motivated research.

[Review on HSPF model for simulation of hydrology and water quality processes].

PubMed

Li, Zhao-fu; Liu, Hong-Yu; Li, Yan

2012-07-01

Hydrological Simulation Program-FORTRAN (HSPF), written in FORTRAN, is one ol the best semi-distributed hydrology and water quality models, which was first developed based on the Stanford Watershed Model. Many studies on HSPF model application were conducted. It can represent the contributions of sediment, nutrients, pesticides, conservatives and fecal coliforms from agricultural areas, continuously simulate water quantity and quality processes, as well as the effects of climate change and land use change on water quantity and quality. HSPF consists of three basic application components: PERLND (Pervious Land Segment) IMPLND (Impervious Land Segment), and RCHRES (free-flowing reach or mixed reservoirs). In general, HSPF has extensive application in the modeling of hydrology or water quality processes and the analysis of climate change and land use change. However, it has limited use in China. The main problems with HSPF include: (1) some algorithms and procedures still need to revise, (2) due to the high standard for input data, the accuracy of the model is limited by spatial and attribute data, (3) the model is only applicable for the simulation of well-mixed rivers, reservoirs and one-dimensional water bodies, it must be integrated with other models to solve more complex problems. At present, studies on HSPF model development are still undergoing, such as revision of model platform, extension of model function, method development for model calibration, and analysis of parameter sensitivity. With the accumulation of basic data and imorovement of data sharing, the HSPF model will be applied more extensively in China.

UTILIZATION OF TREATABILITY AND PILOT TESTS TO PREDICT CAH BIOREMEDIATION

EPA Science Inventory

Multiple tools have been suggested to help in the design of enhanced anaerobic bioremediation systems for CAHs:
- Extensive high quality microcosm testing followed by small-scale, thoroughly observed field pilot tests (i.e., RABITT Protocol, Morse 1998)
- More limited ...

7 CFR 23.6 - Plan of Work.

Code of Federal Regulations, 2012 CFR

2012-01-01

... plans for the programs to be conducted by each cooperating and participating university or college and... colleges and universities, as appropriate, in meeting with high priority extension and research needs of... income opportunities, improving quality of life, improving essential community services and facilities...

7 CFR 23.6 - Plan of Work.

Code of Federal Regulations, 2013 CFR

2013-01-01

... plans for the programs to be conducted by each cooperating and participating university or college and... colleges and universities, as appropriate, in meeting with high priority extension and research needs of... income opportunities, improving quality of life, improving essential community services and facilities...

7 CFR 23.6 - Plan of Work.

Code of Federal Regulations, 2014 CFR

2014-01-01

... plans for the programs to be conducted by each cooperating and participating university or college and... colleges and universities, as appropriate, in meeting with high priority extension and research needs of... income opportunities, improving quality of life, improving essential community services and facilities...

A comprehensive porcine blood transcriptome

USDA-ARS?s Scientific Manuscript database

Blood sample analyses are extensively used in high throughput assays in biomedicine, as well as animal genetics and physiology research. However, the draft quality of the current pig genome (Sscrofa 10.2) is insufficient for accurate interpretation of many of these assays because of incomplete gene ...

Is there a relationship between high-quality performance in major teaching hospitals and residents' knowledge of quality and patient safety?

PubMed

Pingleton, Susan K; Horak, Bernard J; Davis, David A; Goldmann, Donald A; Keroack, Mark A; Dickler, Robert M

2009-11-01

The relationship of the quality of teaching hospitals' clinical performance to resident education in quality and patient safety is unclear. The authors studied residents' knowledge of these areas in major teaching hospitals with higher- and lower-quality performance rankings. They assessed the presence of formal and informal quality curricula to determine whether programmatic differences exist. The authors used qualitative research methodology with purposeful sampling. They gathered data from individual structured interviews with residents and key educational and quality leaders in six medical schools and teaching hospitals, which represented a range of quality performance rankings, geographic regions, and public or private status. No relationship emerged between a hospital's quality status, residents' curriculum, and the residents' understanding of quality. Residents' definitions of quality and safety and their knowledge of the practice-based learning and systems-based practice competencies were indistinguishable between hospitals. Residents in all programs had extensive patient safety knowledge acquired through an informal curriculum in the hospital setting. A formal curriculum existed in only two programs, both of them ambulatory settings. Residents' learning about quality and patient safety is extensive, largely through a positive informal curriculum in the teaching hospital and, less frequently, via a formal curriculum. No relationship was found between the quality performance of the teaching hospital and the residents' curriculum or understanding of quality or safety. Residents seem to learn through an informal curriculum provided by hospital initiatives and resources, and thus these data suggest the importance of major teaching hospitals in quality education.

Genetic diversity provides opportunities for improvement of fresh-cut pepper quality

USDA-ARS?s Scientific Manuscript database

Extensive genetic diversity present in the Capsicum genepool has been utilized extensively to improve pepper disease resistance, fruit quality and varied yield attributes. Little attention has been dedicated to genetic enhancement of pepper fresh-cut quality. We evaluated pepper accessions with dive...

UTILIZATION OF TREATABILITY AND PILOT TESTS TO PREDICT CAH BIOREMEDIATION (Battelle)

EPA Science Inventory

Multiple tools have been suggested to help in the design of enhanced anaerobic bioremediation systems for CAHs:
Extensive high quality microcosm testing followed by small-scale, thoroughly observed, induced flow field pilot tests (i.e. RABITT Protocol, Morse 1998)
More...

XENOPUS LAEVIS: A CULTURING AND REARING PROTOCOL

EPA Science Inventory

Xenopus laevis are used extensively here at MED-Duluth as a model for assessing development toxicity to xenobiotics. As a result, a culturing system has been developed that provides eggs and tadpoles of consistent high quality for use by researchers at the facility. The methods ...

Adoption of Lean Principles in a High-Volume Molecular Diagnostic Microbiology Laboratory

PubMed Central

Mitchell, P. Shawn; Mandrekar, Jayawant N.

2014-01-01

Clinical laboratories are constantly facing challenges to do more with less, enhance quality, improve test turnaround time, and reduce operational expenses. Experience with adopting and applying lean concepts and tools used extensively in the manufacturing industry is described for a high-volume clinical molecular microbiology laboratory, illustrating how operational success and benefits can be achieved. PMID:24829247

Taking Innovation To Scale In Primary Care Practices: The Functions Of Health Care Extension.

PubMed

Ono, Sarah S; Crabtree, Benjamin F; Hemler, Jennifer R; Balasubramanian, Bijal A; Edwards, Samuel T; Green, Larry A; Kaufman, Arthur; Solberg, Leif I; Miller, William L; Woodson, Tanisha Tate; Sweeney, Shannon M; Cohen, Deborah J

2018-02-01

Health care extension is an approach to providing external support to primary care practices with the aim of diffusing innovation. EvidenceNOW was launched to rapidly disseminate and implement evidence-based guidelines for cardiovascular preventive care in the primary care setting. Seven regional grantee cooperatives provided the foundational elements of health care extension-technological and quality improvement support, practice capacity building, and linking with community resources-to more than two hundred primary care practices in each region. This article describes how the cooperatives varied in their approaches to extension and provides early empirical evidence that health care extension is a feasible and potentially useful approach for providing quality improvement support to primary care practices. With investment, health care extension may be an effective platform for federal and state quality improvement efforts to create economies of scale and provide practices with more robust and coordinated support services.

Factors Influencing Perceptions of Service Quality in Cooperative Extension Workers

ERIC Educational Resources Information Center

Anaza, Nwamaka A.; Rutherford, Brian N.; Widdows, Richard

2012-01-01

The authors examined the direct and indirect impact of empowerment on service quality as perceived by Extension staff. Using a sample 283 respondents, the results revealed that along with empowerment, constructs such as job satisfaction and organizational identification positively affected service quality. Undoubtedly, each of these variables…

Evaluation of the quality and health literacy demand of online renal diet information.

PubMed

Lambert, K; Mullan, J; Mansfield, K; Koukomous, A; Mesiti, L

2017-10-01

Dietary modification is critical in the self-management of chronic kidney disease. The present study describes the accuracy, quality and health literacy demand of renal diet information for adults with kidney disease obtained from the Internet and YouTube (www.youtube.com). A comprehensive content analysis was undertaken in April and July 2015 of 254 eligible websites and 161 YouTube videos. The accuracy of the renal diet information was evaluated by comparing the key messages with relevant evidence-based guidelines for the dietary management of people with kidney disease. The DISCERN tool (www.discern.org.uk) was used to evaluate the quality of the material. Health literacy demand was evaluated using the Patient Education Material Assessment Tool (www.ahrq.gov/professionals/prevention-chronic-care/improve/self-mgmt/pemat/index.html) and seven validated readability calculators. The most frequent renal diet topic found online was generic dietary information for people with chronic kidney disease. The proportion of renal diet information obtained from websites that was accurate was 73%. However, this information was mostly of poor quality with extensive shortcomings, difficult to action and written with a high health literacy demand. By contrast, renal diet information available from YouTube was highly understandable and actionable, although only 18% of the videos were accurate, and a large proportion were of poor quality with extensive shortcomings. The most frequent authors of accurate, good quality, understandable, material were government bodies, dietitians, academic institutions and medical organisations. Renal diet information found online that is written by government bodies, dietitians, academic institutions and medical organisations is recommended. Further work is required to improve the quality and, most importantly, the actionability of renal diet information found online. © 2017 The British Dietetic Association Ltd.

Water quality assessment of Australian ports using water quality evaluation indices

PubMed Central

Jahan, Sayka

2017-01-01

Australian ports serve diverse and extensive activities, such as shipping, tourism and fisheries, which may all impact the quality of port water. In this work water quality monitoring at different ports using a range of water quality evaluation indices was applied to assess the port water quality. Seawater samples at 30 stations in the year 2016–2017 from six ports in NSW, Australia, namely Port Jackson, Botany, Kembla, Newcastle, Yamba and Eden, were investigated to determine the physicochemical and biological variables that affect the port water quality. The large datasets obtained were designed to determine the Water Quality Index, Heavy metal Evaluation Index, Contamination Index and newly developed Environmental Water Quality Index. The study revealed medium water quality index and high and medium heavy metal evaluation index at three of the study ports and high contamination index in almost all study ports. Low level dissolved oxygen and higher level of total dissolved solids, turbidity, fecal coliforms, copper, iron, lead, zinc, manganese, cadmium and cobalt are mainly responsible for the poor water qualities of the port areas. Good water quality at the background samples indicated that various port activities are the likely cause for poor water quality inside the port area. PMID:29244876

SPATIAL PATTERNS OF WATER QUALITY AND PLANKTON FROM HIGH-RESOLUTION CONTINUOUS IN SITU SENSING ALONG A 537-KM NEARSHORE TRANSECT OF WESTERN LAKE SUPERIOR, 2004

EPA Science Inventory

A demonstration that the adaptation of electronic instrumentation and towed survey strategies are effective in providing rapid, spatially extensive, and cost effective data for assessment of the Great Lakes.

RECONNAISSANCE FOR ARSENIC, ESTRADIOL, ANTIBIOTICS, AND MICROBIAL RESISTANCE IN POULTRY-DOMINATED CHESAPEAKE BAY WATERSHEDS

EPA Science Inventory

There are concerns about the effects from the high density of poultry feeding operations and the extensive use of feed amendments on water quality in the Shenandoah Valley in Virginia and Delmarva Peninsula. Therefore, we conducted reconnaissance investigations in two Shenandoah ...

A Novel Approach to High-Quality Postmortem Tissue Procurement: The GTEx Project.

PubMed

Carithers, Latarsha J; Ardlie, Kristin; Barcus, Mary; Branton, Philip A; Britton, Angela; Buia, Stephen A; Compton, Carolyn C; DeLuca, David S; Peter-Demchok, Joanne; Gelfand, Ellen T; Guan, Ping; Korzeniewski, Greg E; Lockhart, Nicole C; Rabiner, Chana A; Rao, Abhi K; Robinson, Karna L; Roche, Nancy V; Sawyer, Sherilyn J; Segrè, Ayellet V; Shive, Charles E; Smith, Anna M; Sobin, Leslie H; Undale, Anita H; Valentino, Kimberly M; Vaught, Jim; Young, Taylor R; Moore, Helen M

2015-10-01

The Genotype-Tissue Expression (GTEx) project, sponsored by the NIH Common Fund, was established to study the correlation between human genetic variation and tissue-specific gene expression in non-diseased individuals. A significant challenge was the collection of high-quality biospecimens for extensive genomic analyses. Here we describe how a successful infrastructure for biospecimen procurement was developed and implemented by multiple research partners to support the prospective collection, annotation, and distribution of blood, tissues, and cell lines for the GTEx project. Other research projects can follow this model and form beneficial partnerships with rapid autopsy and organ procurement organizations to collect high quality biospecimens and associated clinical data for genomic studies. Biospecimens, clinical and genomic data, and Standard Operating Procedures guiding biospecimen collection for the GTEx project are available to the research community.

Evaluation of in-network adaptation of scalable high efficiency video coding (SHVC) in mobile environments

NASA Astrophysics Data System (ADS)

Nightingale, James; Wang, Qi; Grecos, Christos; Goma, Sergio

2014-02-01

High Efficiency Video Coding (HEVC), the latest video compression standard (also known as H.265), can deliver video streams of comparable quality to the current H.264 Advanced Video Coding (H.264/AVC) standard with a 50% reduction in bandwidth. Research into SHVC, the scalable extension to the HEVC standard, is still in its infancy. One important area for investigation is whether, given the greater compression ratio of HEVC (and SHVC), the loss of packets containing video content will have a greater impact on the quality of delivered video than is the case with H.264/AVC or its scalable extension H.264/SVC. In this work we empirically evaluate the layer-based, in-network adaptation of video streams encoded using SHVC in situations where dynamically changing bandwidths and datagram loss ratios require the real-time adaptation of video streams. Through the use of extensive experimentation, we establish a comprehensive set of benchmarks for SHVC-based highdefinition video streaming in loss prone network environments such as those commonly found in mobile networks. Among other results, we highlight that packet losses of only 1% can lead to a substantial reduction in PSNR of over 3dB and error propagation in over 130 pictures following the one in which the loss occurred. This work would be one of the earliest studies in this cutting-edge area that reports benchmark evaluation results for the effects of datagram loss on SHVC picture quality and offers empirical and analytical insights into SHVC adaptation to lossy, mobile networking conditions.

Relationship between antigravity control and postural control in young children.

PubMed

Sellers, J S

1988-04-01

The purposes of this study were 1) to determine the relationship between antigravity control (supine flexion and prone extension) and postural control (static and dynamic balance), 2) to determine the quality of antigravity and postural control, and 3) to determine whether sex and ethnic group differences correlate with differences in antigravity control and postural control in young children. I tested 107 black, Hispanic, and Caucasian children in a Head Start program, with a mean age of 61 months. The study results showed significant relationships between antigravity control and postural control. Subjects' supine flexion performance was significantly related to the quantity and quality of their static and dynamic balance performance, whereas prone extension performance was related only to the quality of dynamic balance performance. Quality scale measurements (r = .90) indicated that the children in this study had not yet developed full antigravity or postural control. The study results revealed differences between sexes in the quality of static balance and prone extension performance and ethnic differences in static balance, dynamic balance, and prone extension performance.

An Overview of Controls and Flying Qualities Technology on the F/A-18 High Alpha Research Vehicle

NASA Technical Reports Server (NTRS)

Pahle, Joseph W.; Wichman, Keith D.; Foster, John V.; Bundick, W. Thomas

1996-01-01

The NASA F/A-18 High Alpha Research Vehicle (HARV) has been the flight test bed of a focused technology effort to significantly increase maneuvering capability at high angles of attack. Development and flight test of control law design methodologies, handling qualities metrics, performance guidelines, and flight evaluation maneuvers are described. The HARV has been modified to include two research control effectors, thrust vectoring, and actuated forebody strakes in order to provide increased control power at high angles of attack. A research flight control system has been used to provide a flexible, easily modified capability for high-angle-of-attack research controls. Different control law design techniques have been implemented and flight-tested, including eigenstructure assignment, variable gain output feedback, pseudo controls, and model-following. Extensive piloted simulation has been used to develop nonlinear performance guide-lines and handling qualities criteria for high angles of attack. This paper reviews the development and evaluation of technologies useful for high-angle-of-attack control. Design, development, and flight test of the research flight control system, control laws, flying qualities specifications, and flight test maneuvers are described. Flight test results are used to illustrate some of the lessons learned during flight test and handling qualities evaluations.

Telemedicine using free voice over internet protocol (VoIP) technology.

PubMed

Miller, David J; Miljkovic, Nikola; Chiesa, Chad; Callahan, John B; Webb, Brad; Boedeker, Ben H

2011-01-01

Though dedicated videoteleconference (VTC) systems deliver high quality, low-latency audio and video for telemedical applications, they require expensive hardware and extensive infrastructure. The purpose of this study was to investigate free commercially available Voice over Internet Protocol (VoIP) software as a low cost alternative for telemedicine.

Novel methods to optimize genotypic imputation for low-coverage, next-generation sequence data in crop plants

USDA-ARS?s Scientific Manuscript database

Next-generation sequencing technology such as genotyping-by-sequencing (GBS) made low-cost, but often low-coverage, whole-genome sequencing widely available. Extensive inbreeding in crop plants provides an untapped, high quality source of phased haplotypes for imputing missing genotypes. We introduc...

A Phenomenological Look at 4-H Volunteer Motives for Service

ERIC Educational Resources Information Center

Schrock, Jessalyn; Kelsey, Kathleen D.

2013-01-01

Volunteers play a vital role in 4-H programs. Without their service, many programs would not be possible. Understanding volunteer motives provides Extension educators with tools for finding high-quality volunteers. The research reported here used McClelland's (1985) framework for motivation (affiliation, achievement, and power) and…

Abstract for 1999 Rational Software User Conference

NASA Technical Reports Server (NTRS)

Dunphy, Julia; Rouquette, Nicolas; Feather, Martin; Tung, Yu-Wen

1999-01-01

We develop spacecraft fault-protection software at NASA/JPL. Challenges exemplified by our task: 1) high-quality systems - need for extensive validation & verification; 2) multi-disciplinary context - involves experts from diverse areas; 3) embedded systems - must adapt to external practices, notations, etc.; and 4) development pressures - NASA's mandate of "better, faster, cheaper".

Evaluation of SWAT for estimating ET in irrigated and dryland cropping systems in the Texas High Plains

USDA-ARS?s Scientific Manuscript database

Hydrologic models such as SWAT are used extensively for predicting water availability and water quality responses to alternative management practices. Modeling results have been used by regulatory agencies for developing remedial measures for impaired water bodies and for water planning purposes. Ho...

Student-to-Student Legacies in Exploratory Action Research

ERIC Educational Resources Information Center

Moran, Katherine

2017-01-01

In 2013/2014, I conducted two consecutive cycles of exploratory action research aimed at improving the quality of my French engineering students' oral presentations in English. Each cycle involved a different group of students. I collaborated with the students extensively throughout the project and found that the experience was highly beneficial…

Teacher Mobility and Financial Incentives: A Descriptive Analysis of Denver's ProComp

ERIC Educational Resources Information Center

Fulbeck, Eleanor S.

2014-01-01

Extensive teacher mobility can undermine policy efforts to develop a high-quality workforce. In response, policymakers have increasingly championed financial incentives to retain teachers. In 2006, the Denver Public Schools adopted an alternative teacher compensation reform, the Professional Compensation System for Teachers ("ProComp").…

34 CFR 200.41 - School improvement plan.

Code of Federal Regulations, 2012 CFR

2012-07-01

... school improvement status, for the purpose of providing high-quality professional development to the... activities before school, after school, during the summer, and during any extension of the school year. (d)(1... 34 Education 1 2012-07-01 2012-07-01 false School improvement plan. 200.41 Section 200.41...

34 CFR 200.41 - School improvement plan.

Code of Federal Regulations, 2013 CFR

2013-07-01

... school improvement status, for the purpose of providing high-quality professional development to the... activities before school, after school, during the summer, and during any extension of the school year. (d)(1... 34 Education 1 2013-07-01 2013-07-01 false School improvement plan. 200.41 Section 200.41...

34 CFR 200.41 - School improvement plan.

Code of Federal Regulations, 2014 CFR

2014-07-01

... school improvement status, for the purpose of providing high-quality professional development to the... activities before school, after school, during the summer, and during any extension of the school year. (d)(1... 34 Education 1 2014-07-01 2014-07-01 false School improvement plan. 200.41 Section 200.41...

75 FR 11079 - Extension of Public Comment Period for Water Quality Standards for the State of Florida's Lakes...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-10

... Extension of Public Comment Period for Water Quality Standards for the State of Florida's Lakes and Flowing... comment period. SUMMARY: On January 14, 2010, EPA signed a proposed rule entitled ``Water Quality.... Mail to: Water Docket, U.S. Environmental Protection Agency, Mail code: 2822T, 1200 Pennsylvania Avenue...

78 FR 16474 - Extension of the Period for Comments on the Enhancement of Quality of Software-Related Patents

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-15

...] Extension of the Period for Comments on the Enhancement of Quality of Software-Related Patents AGENCY... announcing the formation of a partnership with the software community to enhance the quality of software-related patents (Software Partnership), and a request for comments on the preparation of patent...

76 FR 64896 - Certain Cut-to-Length Carbon-Quality Steel Plate From the Republic of Korea: Extension of Time...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-19

... DEPARTMENT OF COMMERCE International Trade Administration [A-580-836] Certain Cut-to-Length Carbon-Quality Steel Plate From the Republic of Korea: Extension of Time Limit for Preliminary Results of... on certain cut-to-length carbon-quality steel plate from the Republic of Korea. The period of review...

76 FR 59599 - Extension of Comment Period for Secondary National Ambient Air Quality Standards for Oxides of...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-27

... Sulfur AGENCY: Environmental Protection Agency (EPA). ACTION: Notice of extension of public comment... National Ambient Air Quality Standards for Oxides of Nitrogen and Sulfur to October 10, 2011. DATES: The... Nitrogen and Sulfur'' proposed rule should be addressed to Rich Scheffe, U.S. EPA, Office of Air Quality...

Pre-Scheduled and Self Organized Sleep-Scheduling Algorithms for Efficient K-Coverage in Wireless Sensor Networks

PubMed Central

Hwang, I-Shyan

2017-01-01

The K-coverage configuration that guarantees coverage of each location by at least K sensors is highly popular and is extensively used to monitor diversified applications in wireless sensor networks. Long network lifetime and high detection quality are the essentials of such K-covered sleep-scheduling algorithms. However, the existing sleep-scheduling algorithms either cause high cost or cannot preserve the detection quality effectively. In this paper, the Pre-Scheduling-based K-coverage Group Scheduling (PSKGS) and Self-Organized K-coverage Scheduling (SKS) algorithms are proposed to settle the problems in the existing sleep-scheduling algorithms. Simulation results show that our pre-scheduled-based KGS approach enhances the detection quality and network lifetime, whereas the self-organized-based SKS algorithm minimizes the computation and communication cost of the nodes and thereby is energy efficient. Besides, SKS outperforms PSKGS in terms of network lifetime and detection quality as it is self-organized. PMID:29257078

High Density Aerial Image Matching: State-Of and Future Prospects

NASA Astrophysics Data System (ADS)

Haala, N.; Cavegn, S.

2016-06-01

Ongoing innovations in matching algorithms are continuously improving the quality of geometric surface representations generated automatically from aerial images. This development motivated the launch of the joint ISPRS/EuroSDR project "Benchmark on High Density Aerial Image Matching", which aims on the evaluation of photogrammetric 3D data capture in view of the current developments in dense multi-view stereo-image matching. Originally, the test aimed on image based DSM computation from conventional aerial image flights for different landuse and image block configurations. The second phase then put an additional focus on high quality, high resolution 3D geometric data capture in complex urban areas. This includes both the extension of the test scenario to oblique aerial image flights as well as the generation of filtered point clouds as additional output of the respective multi-view reconstruction. The paper uses the preliminary outcomes of the benchmark to demonstrate the state-of-the-art in airborne image matching with a special focus of high quality geometric data capture in urban scenarios.

Taking Innovation To Scale In Primary Care Practices: The Functions Of Health Care Extension

PubMed Central

Ono, Sarah S.; Crabtree, Benjamin F.; Hemler, Jennifer R.; Balasubramanian, Bijal A.; Edwards, Samuel T.; Green, Larry A.; Kaufman, Arthur; Solberg, Leif I.; Miller, William L.; Woodson, Tanisha Tate; Sweeney, Shannon M.; Cohen, Deborah J.

2018-01-01

Health care extension is an approach to providing external support to primary care practices with the aim of diffusing innovation. EvidenceNOW was launched to rapidly disseminate and implement evidence-based guidelines for cardiovascular preventive care in the primary care setting. Seven regional grantee cooperatives provided the foundational elements of health care extension—technological and quality improvement support, practice capacity building, and linking with community resources—to more than two hundred primary care practices in each region. This article describes how the cooperatives varied in their approaches to extension and provides early empirical evidence that health care extension is a feasible and potentially useful approach for providing quality improvement support to primary care practices. With investment, health care extension may be an effective platform for federal and state quality improvement efforts to create economies of scale and provide practices with more robust and coordinated support services. PMID:29401016

Towards the construction of high-quality mutagenesis libraries.

PubMed

Li, Heng; Li, Jing; Jin, Ruinan; Chen, Wei; Liang, Chaoning; Wu, Jieyuan; Jin, Jian-Ming; Tang, Shuang-Yan

2018-07-01

To improve the quality of mutagenesis libraries in directed evolution strategy. In the process of library transformation, transformants which have been shown to take up more than one plasmid might constitute more than 20% of the constructed library, thereby extensively impairing the quality of the library. We propose a practical transformation method to prevent the occurrence of multiple-plasmid transformants while maintaining high transformation efficiency. A visual library model containing plasmids expressing different fluorescent proteins was used. Multiple-plasmid transformants can be reduced through optimizing plasmid DNA amount used for transformation based on the positive correlation between the occurrence frequency of multiple-plasmid transformants and the logarithmic ratio of plasmid molecules to competent cells. This method provides a simple solution for a seemingly common but often neglected problem, and should be valuable for improving the quality of mutagenesis libraries to enhance the efficiency of directed evolution strategies.

“Putting It All Together” to Improve Resuscitation Quality

PubMed Central

Sutton, Robert M.; Nadkarni, Vinay; Abella, Benjamin S.

2013-01-01

Cardiac arrest is a major public health problem affecting thousands of individuals each year in both the before hospital and in-hospital settings. However, although the scope of the problem is large, the quality of care provided during resuscitation attempts frequently does not meet quality of care standards, despite evidence-based cardiopulmonary resuscitation (CPR) guidelines, extensive provider training, and provider credentialing in resuscitation medicine. Although this fact may be disappointing, it should not be surprising. Resuscitation of the cardiac arrest victim is a highly complex task requiring coordination between various levels and disciplines of care providers during a stressful and relatively infrequent clinical situation. Moreover, it requires a targeted, high-quality response to improve clinical outcomes of patients. Therefore, solutions to improve care provided during resuscitation attempts must be multifaceted and targeted to the diverse number of care providers to be successful. PMID:22107978

Factors Affecting Source-Water Quality after Disturbance of Forests by Wildfire

NASA Astrophysics Data System (ADS)

Murphy, S. F.; Martin, D. A.; McCleskey, R. B.; Writer, J. H.

2015-12-01

Forests yield high-quality water supplies to communities throughout the world, in part because forest cover reduces flooding and the consequent transport of suspended and dissolved constituents to surface water. Disturbance by wildfire reduces or eliminates forest cover, leaving watersheds susceptible to increased surface runoff during storms and reduced ability to retain contaminants. We assessed water-quality response to hydrologic events for three years after a wildfire in the Fourmile Creek Watershed, near Boulder, Colorado, and found that hydrologic and geochemical responses downstream of a burned area were primarily driven by small, brief convective storms that had relatively high, but not unusual, rainfall intensity. Total suspended sediment, dissolved organic carbon, nitrate, and manganese concentrations were 10-156 times higher downstream of a burned area compared to upstream, and water quality was sufficiently impaired to pose water-treatment concerns. The response in both concentration and yield of water-quality constituents differed depending on source availability and dominant watershed processes controlling the constituent. For example, while all constituent concentrations were highest during storm events, annual sediment yields downstream of the burned area were controlled by storm events and subsequent mobilization, whereas dissolved organic carbon yields were more dependent on spring runoff from upstream areas. The watershed response was affected by a legacy of historical disturbance: the watershed had been recovering from extensive disturbance by mining, railroad and road development, logging, and fires in the late 19th and early 20th centuries, and we observed extensive erosion of mine waste in response to these summer storms. Therefore, both storm characteristics and historical disturbance in a burned watershed must be considered when evaluating the role of wildfire on water quality.

Reforming funding for chronic illness: Medicare-CDM.

PubMed

Swerissen, Hal; Taylor, Michael J

2008-02-01

Chronic diseases are a major challenge for the Australian health care system in terms of both the provision of quality care and expenditure, and these challenges will only increase in the future. Various programs have been instituted under the Medicare system to provide increased funding for chronic care, but essentially these programs still follow the traditional fee-for-service model. This paper proposes a realignment and extension of current Medicare chronic disease management programs into a framework that provides general practitioners and other health professionals with the necessary "tools" for high quality care planning and ongoing management, and incorporating international models of outcome-linked funding. The integration of social support services with the Medicare system is also a necessary step in providing high quality care for patients with complex needs requiring additional support.

FQC Dashboard: integrates FastQC results into a web-based, interactive, and extensible FASTQ quality control tool

DOE Office of Scientific and Technical Information (OSTI.GOV)

Brown, Joseph; Pirrung, Meg; McCue, Lee Ann

FQC is software that facilitates large-scale quality control of FASTQ files by carrying out a QC protocol, parsing results, and aggregating quality metrics within and across experiments into an interactive dashboard. The dashboard utilizes human-readable configuration files to manipulate the pages and tabs, and is extensible with CSV data.

Evaluation of bioenergy crop growth and the impacts of bioenergy crops on streamflow, tile drain flow and nutrient losses in an extensively tile-drained watershed using SWAT.

PubMed

Guo, Tian; Cibin, Raj; Chaubey, Indrajeet; Gitau, Margaret; Arnold, Jeffrey G; Srinivasan, Raghavan; Kiniry, James R; Engel, Bernard A

2018-02-01

Large quantities of biofuel production are expected from bioenergy crops at a national scale to meet US biofuel goals. It is important to study biomass production of bioenergy crops and the impacts of these crops on water quantity and quality to identify environment-friendly and productive biofeedstock systems. SWAT2012 with a new tile drainage routine and improved perennial grass and tree growth simulation was used to model long-term annual biomass yields, streamflow, tile flow, sediment load, and nutrient losses under various bioenergy scenarios in an extensively agricultural watershed in the Midwestern US. Simulated results from bioenergy crop scenarios were compared with those from the baseline. The results showed that simulated annual crop yields were similar to observed county level values for corn and soybeans, and were reasonable for Miscanthus, switchgrass and hybrid poplar. Removal of 38% of corn stover (3.74Mg/ha/yr) with Miscanthus production on highly erodible areas and marginal land (17.49Mg/ha/yr) provided the highest biofeedstock production (279,000Mg/yr). Streamflow, tile flow, erosion and nutrient losses were reduced under bioenergy crop scenarios of bioenergy crops on highly erodible areas and marginal land. Corn stover removal did not result in significant water quality changes. The increase in sediment and nutrient losses under corn stover removal could be offset with the combination of other bioenergy crops. Potential areas for bioenergy crop production when meeting the criteria above were small (10.88km 2 ), thus the ability to produce biomass and improve water quality was not substantial. The study showed that corn stover removal with bioenergy crops both on highly erodible areas and marginal land could provide more biofuel production relative to the baseline, and was beneficial to water quality at the watershed scale, providing guidance for further research on evaluation of bioenergy crop scenarios in a typical extensively tile-drained watershed in the Midwestern U.S. Copyright © 2017 Elsevier B.V. All rights reserved.

Learn from the burn: The High Park Fire 5 years later

Treesearch

Sue Miller; Charles Rhodes; Pete Robichaud; Sandra Ryan; Jen Kovecses; Carl Chambers; Sara Rathburn; Jared Heath; Stephanie Kampf; Codie Wilson; Dan Brogan; Brad Piehl; Mary Ellen Miller; John Giordanengo; Erin Berryman; Monique Rocca

2017-01-01

It has been 5 years since the High Park Fire burned over 85,000 acres in Northern Colorado, causing extensive property damage, loss of life, and severe impacts to the water quality of the Poudre River. In the fall of 2016, a conference was organized by the USFS Rocky Mountain Research Station and the Coalition for the Poudre River Watershed to discuss what has been...

Adoption of lean principles in a high-volume molecular diagnostic microbiology laboratory.

PubMed

Mitchell, P Shawn; Mandrekar, Jayawant N; Yao, Joseph D C

2014-07-01

Clinical laboratories are constantly facing challenges to do more with less, enhance quality, improve test turnaround time, and reduce operational expenses. Experience with adopting and applying lean concepts and tools used extensively in the manufacturing industry is described for a high-volume clinical molecular microbiology laboratory, illustrating how operational success and benefits can be achieved. Copyright © 2014, American Society for Microbiology. All Rights Reserved.

Image Quality Ranking Method for Microscopy

PubMed Central

Koho, Sami; Fazeli, Elnaz; Eriksson, John E.; Hänninen, Pekka E.

2016-01-01

Automated analysis of microscope images is necessitated by the increased need for high-resolution follow up of events in time. Manually finding the right images to be analyzed, or eliminated from data analysis are common day-to-day problems in microscopy research today, and the constantly growing size of image datasets does not help the matter. We propose a simple method and a software tool for sorting images within a dataset, according to their relative quality. We demonstrate the applicability of our method in finding good quality images in a STED microscope sample preparation optimization image dataset. The results are validated by comparisons to subjective opinion scores, as well as five state-of-the-art blind image quality assessment methods. We also show how our method can be applied to eliminate useless out-of-focus images in a High-Content-Screening experiment. We further evaluate the ability of our image quality ranking method to detect out-of-focus images, by extensive simulations, and by comparing its performance against previously published, well-established microscopy autofocus metrics. PMID:27364703

The Interplay of Surface Mount Solder Joint Quality and Reliability of Low Volume SMAs

NASA Technical Reports Server (NTRS)

Ghaffarian, R.

1997-01-01

Spacecraft electronics including those used at the Jet Propulsion Laboratory (JPL), demand production of highly reliable assemblies. JPL has recently completed an extensive study, funded by NASA's code Q, of the interplay between manufacturing defects and reliability of ball grid array (BGA) and surface mount electronic components.

Music Matters: How Music Education Helps Students Learn, Achieve, and Succeed

ERIC Educational Resources Information Center

Arts Education Partnership (NJ1), 2011

2011-01-01

Beyond the intrinsic value of music to cultures worldwide, education in music has benefits for young people that transcend the musical domain. The Arts Education Partnership (AEP) reviewed an extensive body of research to identify high-quality, evidence-based studies that document student learning outcomes associated with an education in and…

"Service Wars": The Race To Be the Best in Product Service.

ERIC Educational Resources Information Center

Knox, Robert J.; Lorenzo, Albert L.

To meet the price and quality challenges of foreign manufacturers, U.S. industry has had to invest heavily in technology, incorporating it extensively into both the manufacturing process and product. This trend, termed the "New Industrial Revolution" has created a new challenge--educating technicians to service these highly technical,…

Preschool Inclusion: Key Findings from Research and Implications for Policy

ERIC Educational Resources Information Center

Lawrence, Sharmila; Smith, Sheila; Banerjee, Rashida

2016-01-01

A recent policy statement issued by the U.S. Department of Health and Human Services (HHS) and U.S. Department of Education (DOE) on early childhood inclusion presents extensive recommendations for state and local actions that could improve young children's access to high quality inclusive early childhood programs (HHS/DOE, 2015). This brief…

The Cradle-to-Career Solution

ERIC Educational Resources Information Center

McLester, Susan

2011-01-01

Extensive media coverage of New York City's Harlem Children's Zone's cradle-to-career program over the past several years has served to focus mainstream attention on school reform in a way unprecedented in recent history. Cradle-to-career programs seek to provide children living in poverty with a high-quality birth-to-employment education through…

Librarian contributions to clinical practice guidelines.

PubMed

Cruse, Peggy; Protzko, Shandra

2014-01-01

Librarians have become more involved in developing high quality systematic reviews. Evidence-based practice guidelines are an extension of systematic reviews and offer another significant area for librarian involvement. This column highlights opportunities and challenges for the librarian working on guideline panels and provides practical considerations for meaningful contributions to the guideline creation process.

An investigation of turbulence structure in a low-Reynolds-number incompressible turbulent boundary

NASA Technical Reports Server (NTRS)

White, B. R.; Strataridakis, C. J.

1987-01-01

An existing high turbulence intensity level (5%) atmospheric boundary-layer wind tunnel has been successfully converted to a relatively low level turbulence (0.3%) wind tunnel through extensive modification, testing, and calibration. A splitter plate was designed, built, and installed into the wind-tunnel facility to create thick, mature, two-dimensional turbulent boundary layer flow at zero pressure gradient. Single and cross hot-wire measurements show turbulent boundary layer characteristics of good quality with unusually large physical size, i.e., viscous sublayer of the order of 1 mm high. These confirm the potential ability of the tunnel to be utilized for future high-quality near-wall turbulent boundary layer measurements. It compares very favorably with many low turbulence research tunnels.

Water quality function of an extensive vegetated roof.

PubMed

Todorov, Dimitar; Driscoll, Charles T; Todorova, Svetoslava; Montesdeoca, Mario

2018-06-01

In this paper we present the results of a four-year study of water quality in runoff from an extensive, sedum covered, vegetated roof on an urban commercial building. Monitoring commenced seven months after the roof was constructed, with the first growing season. Stormwater drainage quality function of the vegetated roof was compared to a conventional (impermeable, high-albedo) membrane roof in addition to paired measurements of wet and bulk depositions at the study site. We present concentrations and fluxes of nutrients and major solutes. We discuss seasonal and year-to-year variation in water quality of drainage from the vegetated roof and how it compares with atmospheric deposition and drainage from the impermeable roof. Drainage waters from the vegetated roof exhibited a high concentration of nutrients compared to atmospheric deposition, particularly during the warm temperature growing season. However, nutrient losses were generally low because of the strong retention of water by the vegetated roof. There was marked variation in the retention of nutrients by season due to variations in concentrations in drainage from the vegetated roof. The vegetated roof was a sink of nitrogen, total phosphorus and chloride, and a source of phosphate and dissolved inorganic and organic carbon. Chloride exhibited elevated inputs and leaching during the winter. The drainage from the vegetated and impermeable roofs met the United States Environmental Protection Agency freshwater standards for all parameters, except for total phosphorus. Copyright © 2017 Elsevier B.V. All rights reserved.

Flight test experience with high-alpha control system techniques on the F-14 airplane

NASA Technical Reports Server (NTRS)

Gera, J.; Wilson, R. J.; Enevoldson, E. K.; Nguyen, L. T.

1981-01-01

Improved handling qualities of fighter aircraft at high angles of attack can be provided by various stability and control augmentation techniques. NASA and the U.S. Navy are conducting a joint flight demonstration of these techniques on an F-14 airplane. This paper reports on the flight test experience with a newly designed lateral-directional control system which suppresses such high angle of attack handling qualities problems as roll reversal, wing rock, and directional divergence while simultaneously improving departure/spin resistance. The technique of integrating a piloted simulation into the flight program was used extensively in this program. This technique had not been applied previously to high angle of attack testing and required the development of a valid model to simulate the test airplane at extremely high angles of attack.

[Application of THz technology to nondestructive detection of agricultural product quality].

PubMed

Jiang, Yu-ying; Ge, Hong-yi; Lian, Fei-yu; Zhang, Yuan; Xia, Shan-hong

2014-08-01

With recent development of THz sources and detector, applications of THz radiation to nondestructive testing and quality control have expanded in many fields, such as agriculture, safety inspection and quality control, medicine, biochemistry, communication etc. Compared with other detection technique, being a new kind of technique, THz radiation has low energy, good perspectivity, and high signal-to-noise ratio, and thus can obtain physical, chemical and biological information. This paper first introduces the basic concept of THz radiation and the major properties, then gives an extensive review of recent research progress in detection of the quality of agricultural products via THz technique, analyzes the existing shortcomings of THz detection and discusses the outlook of potential application, finally proposes the new application of THz technique to detection of quality of stored grain.

Foraging habitat quality constrains effectiveness of artificial nest-site provisioning in reversing population declines in a colonial cavity nester.

PubMed

Catry, Inês; Franco, Aldina M A; Rocha, Pedro; Alcazar, Rita; Reis, Susana; Cordeiro, Ana; Ventim, Rita; Teodósio, Joaquim; Moreira, Francisco

2013-01-01

Among birds, breeding numbers are mainly limited by two resources of major importance: food supply and nest-site availability. Here, we investigated how differences in land-use and nest-site availability affected the foraging behaviour, breeding success and population trends of the colonial cavity-dependent lesser kestrel Falco naumanni inhabiting two protected areas. Both areas were provided with artificial nests to increase nest-site availability. The first area is a pseudo-steppe characterized by traditional extensive cereal cultivation, whereas the second area is a previous agricultural zone now abandoned or replaced by forested areas. In both areas, lesser kestrels selected extensive agricultural habitats, such as fallows and cereal fields, and avoided scrubland and forests. In the second area, tracked birds from one colony travelled significantly farther distances (6.2 km ± 1.7 vs. 1.8 km ± 0.4 and 1.9 km ± 0.6) and had significant larger foraging-ranges (144 km(2) vs. 18.8 and 14.8 km(2)) when compared to the birds of two colonies in the extensive agricultural area. Longer foraging trips were reflected in lower chick feeding rates, lower fledging success and reduced chick fitness. Availability and occupation of artificial nests was high in both areas but population followed opposite trends, with a positive increment recorded exclusively in the first area with a large proportion of agricultural areas. Progressive habitat loss around the studied colony in the second area (suitable habitat decreased from 32% in 1990 to only 7% in 2002) is likely the main driver of the recorded population decline and suggests that the effectiveness of bird species conservation based on nest-site provisioning is highly constrained by habitat quality in the surrounding areas. Therefore, the conservation of cavity-dependent species may be enhanced firstly by finding the best areas of remaining habitat and secondly by increasing the carrying capacity of high-quality habitat areas through safe nest-site provisioning.

Foraging Habitat Quality Constrains Effectiveness of Artificial Nest-Site Provisioning in Reversing Population Declines in a Colonial Cavity Nester

PubMed Central

Catry, Inês; Franco, Aldina M. A.; Rocha, Pedro; Alcazar, Rita; Reis, Susana; Cordeiro, Ana; Ventim, Rita; Teodósio, Joaquim; Moreira, Francisco

2013-01-01

Among birds, breeding numbers are mainly limited by two resources of major importance: food supply and nest-site availability. Here, we investigated how differences in land-use and nest-site availability affected the foraging behaviour, breeding success and population trends of the colonial cavity-dependent lesser kestrel Falco naumanni inhabiting two protected areas. Both areas were provided with artificial nests to increase nest-site availability. The first area is a pseudo-steppe characterized by traditional extensive cereal cultivation, whereas the second area is a previous agricultural zone now abandoned or replaced by forested areas. In both areas, lesser kestrels selected extensive agricultural habitats, such as fallows and cereal fields, and avoided scrubland and forests. In the second area, tracked birds from one colony travelled significantly farther distances (6.2 km ±1.7 vs. 1.8 km ±0.4 and 1.9 km ±0.6) and had significant larger foraging-ranges (144 km2 vs. 18.8 and 14.8 km2) when compared to the birds of two colonies in the extensive agricultural area. Longer foraging trips were reflected in lower chick feeding rates, lower fledging success and reduced chick fitness. Availability and occupation of artificial nests was high in both areas but population followed opposite trends, with a positive increment recorded exclusively in the first area with a large proportion of agricultural areas. Progressive habitat loss around the studied colony in the second area (suitable habitat decreased from 32% in 1990 to only 7% in 2002) is likely the main driver of the recorded population decline and suggests that the effectiveness of bird species conservation based on nest-site provisioning is highly constrained by habitat quality in the surrounding areas. Therefore, the conservation of cavity-dependent species may be enhanced firstly by finding the best areas of remaining habitat and secondly by increasing the carrying capacity of high-quality habitat areas through safe nest-site provisioning. PMID:23484016

[Effects of nitrogen management on yield, quality, nitrogen accumulation and its transportation of watermelon in gravel-mulched field].

PubMed

Ma, Zhong-ming; Du, Shao-ping; Xue, Liang

2015-11-01

The effects of nitrogen management on yield, quality, nitrogen and dry matter accumulation and transportation of watermelon in sand field were studied based on a field experiment. The results showed that too low or too high basal nitrogen fertilzation was unfavorable to seedling growth of watermelon in sand field, and no nitrogen application at vine extension or fruiting stages limited the formation of 'source' or 'sink'. At the same nitrogen rate, compared with the traditional T1 treatment (30% basal N fertilizer + 70% N fertilizer in vine extension), the nitrogen and dry matter accumulation of vegetative organs of T4 treatment (30% basal N fertilizer + 30% N fertilizer in vine extension + 40% N fertilizer in fruiting) and T6 treatment (100% basal N fertilizer + NAM) were reduced significantly, but the nitrogen and dry matter accumulation of fruit were increased significantly in the flushing period. The nitrogen transportation ratio and nitrogen contribution ratio of T4 were 33.6% and 12.0%, respectively. Compared to T1, the nitrogen harvest index, nitrogen fertilizer partial factor productivity and nitrogen fertilizer recovery efficiency of T4 and T6 treatments increased by 14.1% and 12.7%, 11.6% and 12.5%, 5.3% and 8.7%, respectively, and yield of watermelon increased by 11.6% and 12.5%, the soluble sugar, effective acid, the ratio of sugar and acid, Vc content increased by 16.5% and 11.7%, 4.5% and 2.8%, 19.4% and 13.4%, 35.6% and 19.0%, respectively. Therefore, T4 and T6 treatments were the optimal nitrogen fertilizer management mode which could not only achieve high yield and quality but also obtain high nitrogen fertilizer use efficiency in sand field. T6 treatment was the best nitrogen fertilizer management mode considering reduction of fertilizing labor intensity and extending service time of gravel-mulched field.

Grinding model and material removal mechanism of medical nanometer zirconia ceramics.

PubMed

Zhang, Dongkun; Li, Changhe; Jia, Dongzhou; Wang, Sheng; Li, Runze; Qi, Xiaoxiao

2014-01-01

Many patents have been devoted to developing medical nanometer zirconia ceramic grinding techniques that can significantly improve both workpiece surface integrity and grinding quality. Among these patents is a process for preparing ceramic dental implants with a surface for improving osseo-integration by sand abrasive finishing under a jet pressure of 1.5 bar to 8.0 bar and with a grain size of 30 µm to 250 µm. Compared with other materials, nano-zirconia ceramics exhibit unmatched biomedical performance and excellent mechanical properties as medical bone tissue and dentures. The removal mechanism of nano-zirconia materials includes brittle fracture and plastic removal. Brittle fracture involves crack formation, extension, peeling, and chipping to completely remove debris. Plastic removal is similar to chip formation in metal grinding, including rubbing, ploughing, and the formation of grinding debris. The materials are removed in shearing and chipping. During brittle fracture, the grinding-led transverse and radial extension of cracks further generate local peeling of blocks of the material. In material peeling and removal, the mechanical strength and surface quality of the workpiece are also greatly reduced because of crack extension. When grinding occurs in the plastic region, plastic removal is performed, and surface grinding does not generate grinding fissures and surface fracture, producing clinically satisfactory grinding quality. With certain grinding conditions, medical nanometer zirconia ceramics can be removed through plastic flow in ductile regime. In this study, we analyzed the critical conditions for the transfer of brittle and plastic removal in nano-zirconia ceramic grinding as well as the high-quality surface grinding of medical nanometer zirconia ceramics by ELID grinding.

CerebroMatic: A Versatile Toolbox for Spline-Based MRI Template Creation

PubMed Central

Wilke, Marko; Altaye, Mekibib; Holland, Scott K.

2017-01-01

Brain image spatial normalization and tissue segmentation rely on prior tissue probability maps. Appropriately selecting these tissue maps becomes particularly important when investigating “unusual” populations, such as young children or elderly subjects. When creating such priors, the disadvantage of applying more deformation must be weighed against the benefit of achieving a crisper image. We have previously suggested that statistically modeling demographic variables, instead of simply averaging images, is advantageous. Both aspects (more vs. less deformation and modeling vs. averaging) were explored here. We used imaging data from 1914 subjects, aged 13 months to 75 years, and employed multivariate adaptive regression splines to model the effects of age, field strength, gender, and data quality. Within the spm/cat12 framework, we compared an affine-only with a low- and a high-dimensional warping approach. As expected, more deformation on the individual level results in lower group dissimilarity. Consequently, effects of age in particular are less apparent in the resulting tissue maps when using a more extensive deformation scheme. Using statistically-described parameters, high-quality tissue probability maps could be generated for the whole age range; they are consistently closer to a gold standard than conventionally-generated priors based on 25, 50, or 100 subjects. Distinct effects of field strength, gender, and data quality were seen. We conclude that an extensive matching for generating tissue priors may model much of the variability inherent in the dataset which is then not contained in the resulting priors. Further, the statistical description of relevant parameters (using regression splines) allows for the generation of high-quality tissue probability maps while controlling for known confounds. The resulting CerebroMatic toolbox is available for download at http://irc.cchmc.org/software/cerebromatic.php. PMID:28275348

CerebroMatic: A Versatile Toolbox for Spline-Based MRI Template Creation.

PubMed

Wilke, Marko; Altaye, Mekibib; Holland, Scott K

2017-01-01

Brain image spatial normalization and tissue segmentation rely on prior tissue probability maps. Appropriately selecting these tissue maps becomes particularly important when investigating "unusual" populations, such as young children or elderly subjects. When creating such priors, the disadvantage of applying more deformation must be weighed against the benefit of achieving a crisper image. We have previously suggested that statistically modeling demographic variables, instead of simply averaging images, is advantageous. Both aspects (more vs. less deformation and modeling vs. averaging) were explored here. We used imaging data from 1914 subjects, aged 13 months to 75 years, and employed multivariate adaptive regression splines to model the effects of age, field strength, gender, and data quality. Within the spm/cat12 framework, we compared an affine-only with a low- and a high-dimensional warping approach. As expected, more deformation on the individual level results in lower group dissimilarity. Consequently, effects of age in particular are less apparent in the resulting tissue maps when using a more extensive deformation scheme. Using statistically-described parameters, high-quality tissue probability maps could be generated for the whole age range; they are consistently closer to a gold standard than conventionally-generated priors based on 25, 50, or 100 subjects. Distinct effects of field strength, gender, and data quality were seen. We conclude that an extensive matching for generating tissue priors may model much of the variability inherent in the dataset which is then not contained in the resulting priors. Further, the statistical description of relevant parameters (using regression splines) allows for the generation of high-quality tissue probability maps while controlling for known confounds. The resulting CerebroMatic toolbox is available for download at http://irc.cchmc.org/software/cerebromatic.php.

Reliability of a visual scoring system with fluorescent tracers to assess dermal pesticide exposure.

PubMed

Aragon, Aurora; Blanco, Luis; Lopez, Lylliam; Liden, Carola; Nise, Gun; Wesseling, Catharina

2004-10-01

We modified Fenske's semi-quantitative 'visual scoring system' of fluorescent tracer deposited on the skin of pesticide applicators and evaluated its reproducibility in the Nicaraguan setting. The body surface of 33 farmers, divided into 31 segments, was videotaped in the field after spraying with a pesticide solution containing a fluorescent tracer. A portable UV lamp was used for illumination in a foldaway dark room. The videos of five farmers were randomly selected. The scoring was based on a matrix with extension of fluorescent patterns (scale 0-5) on the ordinate and intensity (scale 0-5) on the abscissa, with the product of these two ranks as the final score for each body segment (0-25). Five medical students rated and evaluated the quality of 155 video images having undergone 4 h of training. Cronbach alpha coefficients and two-way random effects intraclass correlation coefficients (ICC) with absolute agreement were computed to assess inter-rater reliability. Consistency was high (Cronbach alpha = 0.96), but the scores differed substantially between raters. The overall ICC was satisfactory [0.75; 95% confidence interval (CI) = 0.62-0.83], but it was lower for intensity (0.54; 95% CI = 0.40-0.66) and higher for extension (0.80; 95% CI = 0.71-0.86). ICCs were lowest for images with low scores and evaluated as low quality, and highest for images with high scores and high quality. Inter-rater reliability coefficients indicate repeatability of the scoring system. However, field conditions for recording fluorescence should be improved to achieve higher quality images, and training should emphasize a better mechanism for the reading of body areas with low contamination.

Ceramic and coating applications in the hostile environment of a high temperature hypersonic wind tunnel. [Langley 8-foot high temperature structures tunnel

NASA Technical Reports Server (NTRS)

Puster, R. L.; Karns, J. R.; Vasquez, P.; Kelliher, W. C.

1981-01-01

A Mach 7, blowdown wind tunnel was used to investigate aerothermal structural phenomena on large to full scale high speed vehicle components. The high energy test medium, which provided a true temperature simulation of hypersonic flow at 24 to 40 km altitude, was generated by the combustion of methane with air at high pressures. Since the wind tunnel, as well as the models, must be protected from thermally induced damage, ceramics and coatings were used extensively. Coatings were used both to protect various wind tunnel components and to improve the quality of the test stream. Planned modifications for the wind tunnel included more extensive use of ceramics in order to minimize the number of active cooling systems and thus minimize the inherent operational unreliability and cost that accompanies such systems. Use of nonintrusive data acquisition techniques, such as infrared radiometry, allowed more widespread use of ceramics for models to be tested in high energy wind tunnels.

Frances Keesler Graham (1918-2013).

PubMed

Berg, W Keith

2014-09-01

Frances Keesler Graham, noted psychophysiologist and developmental researcher, died on April 16, 2013. Fran was born in Canastota, New York, on August 1, 1918. Fran's high-quality research, her success in obtaining 39 years of uninterrupted funding, and the very high regard in which she was held among her colleagues led to numerous awards and honors. Fran was demanding but equally willing to provide extensive assistance to students willing to work hard. (c) 2014 APA, all rights reserved.

A Conceptual Framework for Quality of Care

PubMed Central

Mosadeghrad, Ali Mohammad

2012-01-01

Despite extensive research on defining and measuring health care quality, little attention has been given to different stakeholders’ perspectives of high-quality health care services. The main purpose of this study was to explore the attributes of quality healthcare in the Iranian context. Exploratory in-depth individual and focus group interviews were conducted with key healthcare stakeholders including clients, providers, managers, policy makers, payers, suppliers and accreditation panel members to identify the healthcare service quality attributes and dimensions. Data analysis was carried out by content analysis, with the constant comparative method. Over 100 attributes of quality healthcare service were elicited and grouped into five categories. The dimensions were: efficacy, effectiveness, efficiency, empathy, and environment. Consequently, a comprehensive model of service quality was developed for health care context. The findings of the current study led to a conceptual framework of healthcare quality. This model leads to a better understanding of the different aspects of quality in health care and provides a better basis for defining, measuring and controlling quality of health care services. PMID:23922534

New irradiation facilities for development of production methods of medical radionuclides at cyclotrons at Forschungszentrum Jülich

NASA Astrophysics Data System (ADS)

Spellerberg, S.; Scholten, B.; Spahn, I.; Felden, O.; Gebel, R.; Qaim, S. M.; Bai, M.; Neumaier, B.

2017-05-01

An essential basis for research and development work on radiopharmaceuticals is the efficient production of radionuclides of high quality. In this process research-oriented studies aiming for elucidation of biochemical processes require novel products. The radionuclide development at INM-5 entails basic research, e.g. the determination of nuclear reaction data, as well as technical aspects of practical production, such as high-current targetry, chemical separation, formulation and quality control. In this work developments, adaptation and optimization of irradiation facilities at the BC 1710, JULIC as Injector of COSY and COSY itself are summarized, which shall allow the extension of radionuclide production possibilities, aiming at innovations in medical applications.

Verification testing of the compression performance of the HEVC screen content coding extensions

NASA Astrophysics Data System (ADS)

Sullivan, Gary J.; Baroncini, Vittorio A.; Yu, Haoping; Joshi, Rajan L.; Liu, Shan; Xiu, Xiaoyu; Xu, Jizheng

2017-09-01

This paper reports on verification testing of the coding performance of the screen content coding (SCC) extensions of the High Efficiency Video Coding (HEVC) standard (Rec. ITU-T H.265 | ISO/IEC 23008-2 MPEG-H Part 2). The coding performance of HEVC screen content model (SCM) reference software is compared with that of the HEVC test model (HM) without the SCC extensions, as well as with the Advanced Video Coding (AVC) joint model (JM) reference software, for both lossy and mathematically lossless compression using All-Intra (AI), Random Access (RA), and Lowdelay B (LB) encoding structures and using similar encoding techniques. Video test sequences in 1920×1080 RGB 4:4:4, YCbCr 4:4:4, and YCbCr 4:2:0 colour sampling formats with 8 bits per sample are tested in two categories: "text and graphics with motion" (TGM) and "mixed" content. For lossless coding, the encodings are evaluated in terms of relative bit-rate savings. For lossy compression, subjective testing was conducted at 4 quality levels for each coding case, and the test results are presented through mean opinion score (MOS) curves. The relative coding performance is also evaluated in terms of Bjøntegaard-delta (BD) bit-rate savings for equal PSNR quality. The perceptual tests and objective metric measurements show a very substantial benefit in coding efficiency for the SCC extensions, and provided consistent results with a high degree of confidence. For TGM video, the estimated bit-rate savings ranged from 60-90% relative to the JM and 40-80% relative to the HM, depending on the AI/RA/LB configuration category and colour sampling format.

Postharvest and sensory evaluation of selected ‘Hass’-‘Bacon’ avocado hybrids grown in East-Central Florida

USDA-ARS?s Scientific Manuscript database

Avocado (Persea americana Mill.) is a high-value fruit that continues to increase in consumer demand. A population of ‘Hass’-‘Bacon’ hybrids was planted at USDA-ARS, Fort Pierce as part of a study to find selections with good horticultural and postharvest quality traits for Florida. Extensive pheno...

The Open Society and Coach Education: A Philosophical Agenda for Policy Reform and Future Sociological Research

ERIC Educational Resources Information Center

Piggott, David

2015-01-01

Background: The realisation of the strategic importance of high quality coaching to the achievement of national sport policy objectives is resulting in extensive movements to professionalise the coaching industry. Interest in coach education is therefore growing among academics and policy-makers alike. A recent review of literature in this field,…

A spatial evaluation of global wildfire-water risks to human and natural systems

Treesearch

Francois-Nicolas Robinne; Kevin D. Bladon; Carol Miller; Marc-Andre Parisien; Jerome Mathieu; Mike D. Flannigan

2017-01-01

The large mediatic coverage of recent massive wildfires across the world has emphasized the vulnerability of freshwater resources. The extensive hydrogeomorphic effects from a wildfire can impair the ability of watersheds to provide safe drinking water to downstream communities and high-quality water to maintain riverine ecosystem health. Safeguarding water use for...

NAPLAN, MySchool and Accountability: Teacher Perceptions of the Effects of Testing

ERIC Educational Resources Information Center

Thompson, Greg

2013-01-01

This paper explores Rizvi and Lingard's (2010) idea of the "local vernacular" of the global education policy trend of using high-stakes testing to increase accountability and transparency, and by extension quality, within schools and education systems in Australia. In the first part of the paper a brief context of the policy trajectory…

Time Spent in Child Care: How and Why Does It Affect Social Development?

ERIC Educational Resources Information Center

Huston, Aletha C.; Bobbitt, Kaeley C.; Bentley, Alison

2015-01-01

Children who experience early and extensive child care, especially center-based care, are rated by teachers as having more externalizing behavior problems than are other children. This association is reduced, but not eliminated, when care is of high quality, and it varies by socioeconomic disadvantage and the type of behavior assessed. We examine…

Ensuring Data Quality in Extension Research and Evaluation Studies

ERIC Educational Resources Information Center

Radhakrishna, Rama; Tobin, Daniel; Brennan, Mark; Thomson, Joan

2012-01-01

This article presents a checklist as a guide for Extension professionals to use in research and evaluation studies they carry out. A total of 40 statements grouped under eight data quality components--relevance, objectivity, validity, reliability, integrity, generalizability, completeness, and utility--are identified to ensure that research…

Missouri Small Farm Family Program. Revised.

ERIC Educational Resources Information Center

Enlow, George; And Others

Records maintained by rural extension designees on the Missouri Small Farm Family Program, (initiated in 1972 by the cooperative extension service to help low income farm families learn to use available resources to improve their quality of life) provided data re: family characteristics, farm improvement progress, and improvement in the quality of…

Relationships between abstract features and methodological quality explained variations of social media activity derived from systematic reviews about psoriasis interventions.

PubMed

Ruano, J; Aguilar-Luque, M; Isla-Tejera, B; Alcalde-Mellado, P; Gay-Mimbrera, J; Hernandez-Romero, José Luis; Sanz-Cabanillas, J L; Maestre-López, B; González-Padilla, M; Carmona-Fernández, P J; Gómez-García, F; García-Nieto, A Vélez

2018-05-24

The aim of this study was to describe the relationship among abstract structure, readability, and completeness, and how these features may influence social media activity and bibliometric results, considering systematic reviews (SRs) about interventions in psoriasis classified by methodological quality. Systematic literature searches about psoriasis interventions were undertaken on relevant databases. For each review, methodological quality was evaluated using the Assessing the Methodological Quality of Systematic Reviews (AMSTAR) tool. Abstract extension, structure, readability, and quality and completeness of reporting were analyzed. Social media activity, which consider Twitter and Facebook mention counts, as well as Mendeley readers and Google scholar citations were obtained for each article. Analyses were conducted to describe any potential influence of abstract characteristics on review's social media diffusion. We classified 139 intervention SRs as displaying high/moderate/low methodological quality. We observed that abstract readability of SRs has been maintained high for last 20 years, although there are some differences based on their methodological quality. Free-format abstracts were most sensitive to the increase of text readability as compared with more structured abstracts (IMRAD or 8-headings), yielding opposite effects on their quality and completeness depending on the methodological quality: a worsening in low quality reviews and an improvement in those of high-quality. Both readability indices and PRISMA for Abstract total scores showed an inverse relationship with social media activity and bibliometric results in high methodological quality reviews but not in those of lower quality. Our results suggest that increasing abstract readability must be specially considered when writing free-format summaries of high-quality reviews, because this fact correlates with an improvement of their completeness and quality, and this may help to achieve broader social media visibility and article usage. Copyright © 2018 Elsevier Inc. All rights reserved.

Recognizing Academic Performance, Sleep Quality, Stress Level, and Mental Health using Personality Traits, Wearable Sensors and Mobile Phones

PubMed Central

Sano, Akane; Phillips, Andrew J.; Yu, Amy Z.; McHill, Andrew W.; Taylor, Sara; Jaques, Natasha; Czeisler, Charles A.; Klerman, Elizabeth B.; Picard, Rosalind W.

2017-01-01

What can wearable sensors and usage of smart phones tell us about academic performance, self-reported sleep quality, stress and mental health condition? To answer this question, we collected extensive subjective and objective data using mobile phones, surveys, and wearable sensors worn day and night from 66 participants, for 30 days each, totaling 1,980 days of data. We analyzed daily and monthly behavioral and physiological patterns and identified factors that affect academic performance (GPA), Pittsburg Sleep Quality Index (PSQI) score, perceived stress scale (PSS), and mental health composite score (MCS) from SF-12, using these month-long data. We also examined how accurately the collected data classified the participants into groups of high/low GPA, good/poor sleep quality, high/low self-reported stress, high/low MCS using feature selection and machine learning techniques. We found associations among PSQI, PSS, MCS, and GPA and personality types. Classification accuracies using the objective data from wearable sensors and mobile phones ranged from 67–92%. PMID:28516162

Key elements of high-quality practice organisation in primary health care: a systematic review.

PubMed

Crossland, Lisa; Janamian, Tina; Jackson, Claire L

2014-08-04

To identify elements that are integral to high-quality practice and determine considerations relating to high-quality practice organisation in primary care. A narrative systematic review of published and grey literature. Electronic databases (PubMed, CINAHL, the Cochrane Library, Embase, Emerald Insight, PsycInfo, the Primary Health Care Research and Information Service website, Google Scholar) were searched in November 2013 and used to identify articles published in English from 2002 to 2013. Reference lists of included articles were searched for relevant unpublished articles and reports. Data were configured at the study level to allow for the inclusion of findings from a broad range of study types. Ten elements were most often included in the existing organisational assessment tools. A further three elements were identified from an inductive thematic analysis of descriptive articles, and were noted as important considerations in effective quality improvement in primary care settings. Although there are some validated tools available to primary care that identify and build quality, most are single-strategy approaches developed outside health care settings. There are currently no validated organisational improvement tools, designed specifically for primary health care, which combine all elements of practice improvement and whose use does not require extensive external facilitation.

FQC Dashboard: integrates FastQC results into a web-based, interactive, and extensible FASTQ quality control tool

DOE Office of Scientific and Technical Information (OSTI.GOV)

Brown, Joseph; Pirrung, Meg; McCue, Lee Ann

FQC is software that facilitates quality control of FASTQ files by carrying out a QC protocol using FastQC, parsing results, and aggregating quality metrics into an interactive dashboard designed to richly summarize individual sequencing runs. The dashboard groups samples in dropdowns for navigation among the data sets, utilizes human-readable configuration files to manipulate the pages and tabs, and is extensible with CSV data.

FQC Dashboard: integrates FastQC results into a web-based, interactive, and extensible FASTQ quality control tool

DOE PAGES

Brown, Joseph; Pirrung, Meg; McCue, Lee Ann

2017-06-09

FQC is software that facilitates quality control of FASTQ files by carrying out a QC protocol using FastQC, parsing results, and aggregating quality metrics into an interactive dashboard designed to richly summarize individual sequencing runs. The dashboard groups samples in dropdowns for navigation among the data sets, utilizes human-readable configuration files to manipulate the pages and tabs, and is extensible with CSV data.

LIHE Spectral Dynamics and Jaguar Data Acquisition System Measurement Assurance Results 2014.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Covert, Timothy T.; Willis, Michael David; Radtke, Gregg Arthur

2015-06-01

The Light Initiated High Explosive (LIHE) facility performs high rigor, high consequence impulse testing for the nuclear weapons (NW) community. To support the facility mission, LIHE's extensive data acquisition system (DAS) is comprised of several discrete components as well as a fully integrated system. Due to the high consequence and high rigor of the testing performed at LIHE, a measurement assurance plan (MAP) was developed in collaboration with NW system customers to meet their data quality needs and to provide assurance of the robustness of the LIHE DAS. While individual components of the DAS have been calibrated by the SNLmore » Primary Standards Laboratory (PSL), the integrated nature of this complex system requires verification of the complete system, from end-to-end. This measurement assurance plan (MAP) report documents the results of verification and validation procedures used to ensure that the data quality meets customer requirements.« less

Food processing by high hydrostatic pressure.

PubMed

Yamamoto, Kazutaka

2017-04-01

High hydrostatic pressure (HHP) process, as a nonthermal process, can be used to inactivate microbes while minimizing chemical reactions in food. In this regard, a HHP level of 100 MPa (986.9 atm/1019.7 kgf/cm 2 ) and more is applied to food. Conventional thermal process damages food components relating color, flavor, and nutrition via enhanced chemical reactions. However, HHP process minimizes the damages and inactivates microbes toward processing high quality safe foods. The first commercial HHP-processed foods were launched in 1990 as fruit products such as jams, and then some other products have been commercialized: retort rice products (enhanced water impregnation), cooked hams and sausages (shelf life extension), soy sauce with minimized salt (short-time fermentation owing to enhanced enzymatic reactions), and beverages (shelf life extension). The characteristics of HHP food processing are reviewed from viewpoints of nonthermal process, history, research and development, physical and biochemical changes, and processing equipment.

[Analysis on current status of drinking water quality in rural areas of China].

PubMed

Zhang, L; Chen, Y; Chen, C; Wang, H; Yan, H Z; Zhao, Y C

1997-01-01

An investigation on drinking water quality in rural areas of 180 counties in 26 provinces, municipalities and autonomous regions of China was carried out. The population surveyed was 89.39 million. 69.6% of which was supplied with ground water. Central water supply systems served 47.1% of population. Quality of drinking water was graded according to the "Guidelines for Implementation of the 'Sanitary Standard for Drinking Water' in Rural Areas". The rate of population supplied with unqualified drinking water was 42.7%. The bacteriological indices of drinking water exceeded the standard seriously. Organic pollution occurred extensively. Some regions supplied with water of high concentration of fluoride.

Search for Open binaries in the Southern Celestial Hemisphere using SPM4

NASA Astrophysics Data System (ADS)

Dávila, E.; Vieira, K.; Rosales, K.

2018-01-01

Open binaries' weak gravitational binding makes them vulnerable to any perturbation, turning them into excellent probes of the gravitational field where they are located. Currently there are only a few hundreds known or suspected open binaries, therefore a search for more of these systems is highly encouraging by looking for pairs of stars with common proper motions in an extensive, deep, and high quality astrometric catalog such as the SPM4 (Girard et al. 2011).

75 FR 77828 - Certain Hot-Rolled Flat-Rolled Carbon-Quality Steel Products From Brazil: Extension of Time Limit...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-14

... DEPARTMENT OF COMMERCE International Trade Administration [C-351-829] Certain Hot-Rolled Flat-Rolled Carbon-Quality Steel Products From Brazil: Extension of Time Limit for Final Results of Countervailing Duty Administrative Review AGENCY: Import Administration, International Trade Administration, Department of Commerce DATES: Effective Date:...

Developing a Mobile Extension Course for Youth Livestock Producers

ERIC Educational Resources Information Center

Weitzenkamp, Deborah; Dam, Karna; Chichester, Lindsay

2015-01-01

The 4-H Livestock Quality Assurance course is a mobile Extension course for youth and youth leaders. In 3 years of implementation, over 6,600 participants from 16 states have learned about good production practices for animal agriculture through the innovative online Nebraska Livestock Quality Assurance course. By evaluating the needs of our youth…

Quality Enhancement and Educational Professional Development

ERIC Educational Resources Information Center

Knight, Peter

2006-01-01

There is a strong international interest in the enhancement of teaching quality. Enhancement is a big job because teaching is an extensive activity. It is a complex job because learning to teach is not, mainly, a formal process: non-formal, practice-based learning is more significant. These two points, extensiveness and practice-based learning,…

Health information technology and physicians' perceptions of healthcare quality.

PubMed

Fang, Hai; Peifer, Karen L; Chen, Jie; Rizzo, John A

2011-03-01

To investigate the relationship between the use of health information technology (HIT) and physician perceptions of providing high-quality care and to determine whether this relationship has changed over time. We used 2 waves of longitudinal data from the Community Tracking Study Physician Surveys, 2000-2001 and 2004-2005. Three measures of HIT were examined: a binary variable measuring the use of at least 1 type of HIT, a continuous variable measuring the total number of HIT types, and a binary variable measuring use of all 5 HIT types related to "meaningful use" of HIT as defined by Centers for Medicare and Medicaid Services. Three multivariate models were estimated to study the effect of each HIT measure on physicians' perception of providing high-quality care. Individual fixed-effects estimation also was used to control for individual time-invariant factors. Using at least 1 type of HIT significantly enhanced physicians' perception of providing high-quality care in 2000-2001, but not in 2004-2005. The marginal effect of adding 1 extra HIT type was positive and statistically significant in both periods. The association between using all 5 HIT types related to meaningful use and perceived quality was statistically significant in 2000-2001, but not in 2004-2005. Health information technology has become a multifunctional system and appears to have enhanced physicians' perception of providing high-quality care. Physicians' perceptions of medical care quality improved as the number of HIT types used increased. This study supports more extensive use of HIT in physician practices.

Evaluation of High-Speed Civil Transport Handling Qualities Criteria with Supersonic Flight Data

NASA Technical Reports Server (NTRS)

Cox, Timothy H.; Jackson, Dante W.

1997-01-01

Most flying qualities criteria have been developed from data in the subsonic flight regime. Unique characteristics of supersonic flight raise questions about whether these criteria successfully extend into the supersonic flight regime. Approximately 25 years ago NASA Dryden Flight Research Center addressed this issue with handling qualities evaluations of the XB-70 and YF-12. Good correlations between some of the classical handling qualities parameters, such as the control anticipation parameter as a function of damping, were discovered. More criteria have been developed since these studies. Some of these more recent criteria are being used in designing the High-Speed Civil Transport (HSCT). A second research study recently addressed this issue through flying qualities evaluations of the SR-71 at Mach 3. The research goal was to extend the high-speed flying qualities experience of large airplanes and to evaluate more recent MIL-STD-1797 criteria against pilot comments and ratings. Emphasis was placed on evaluating the criteria used for designing the HSCT. XB-70 and YF-12 data from the previous research supplemented the SR-71 data. The results indicate that the criteria used in the HSCT design are conservative and should provide good flying qualities for typical high-speed maneuvering. Additional results show correlation between the ratings and comments and criteria for gradual maneuvering with precision control. Correlation is shown between ratings and comments and an extension of the Neal/Smith criterion using normal acceleration instead of pitch rate.

Analyzing the Natural Resource Extension Needs of Spanish-Speakers: A Perspective from Florida

ERIC Educational Resources Information Center

Wyman, Miriam; Escobedo, Francisco; Varela, Sebastian; Asuaje, Cesar; Mayer, Henry; Swisher, Mickie; Hermansen-Baez, Annie

2011-01-01

Hispanics are the country's fastest growing minority group. The study reported here surveyed and assessed Extension agents from two demographically different regions in Florida on perceptions and attitudes about the need, quality, and dissemination of Spanish Extension materials. Results showed Extension programs are important sources of…

Practical, Real-Time, and Robust Watermarking on the Spatial Domain for High-Definition Video Contents

NASA Astrophysics Data System (ADS)

Kim, Kyung-Su; Lee, Hae-Yeoun; Im, Dong-Hyuck; Lee, Heung-Kyu

Commercial markets employ digital right management (DRM) systems to protect valuable high-definition (HD) quality videos. DRM system uses watermarking to provide copyright protection and ownership authentication of multimedia contents. We propose a real-time video watermarking scheme for HD video in the uncompressed domain. Especially, our approach is in aspect of practical perspectives to satisfy perceptual quality, real-time processing, and robustness requirements. We simplify and optimize human visual system mask for real-time performance and also apply dithering technique for invisibility. Extensive experiments are performed to prove that the proposed scheme satisfies the invisibility, real-time processing, and robustness requirements against video processing attacks. We concentrate upon video processing attacks that commonly occur in HD quality videos to display on portable devices. These attacks include not only scaling and low bit-rate encoding, but also malicious attacks such as format conversion and frame rate change.

Catalytic conversion of Chlorella pyrenoidosa to biofuels in supercritical alcohols over zeolites.

PubMed

Yang, Le; Ma, Rui; Ma, Zewei; Li, Yongdan

2016-06-01

Microalgae have been considered as the feedstock for the third generation biofuels production, given its high lipid content and fast productivity. Herein, a catalytic approach for microalgae liquefaction to biocrude is examined in a temperature range of 250-300°C in methanol and ethanol over zeolites. Higher biocrude yield was achieved in ethanol and at lower temperatures, while better quality biocrude with higher light biocrude ratio and lower average molecular weight (Mw) was favored in methanol and at higher temperatures. Application of zeolites improves the biocrude quality significantly. Among the catalysts, HY shows the strongest acidity and performs the best to produce high quality biocrude. Solid residues have been extensively explored with thermal gravity analysis and elemental analysis. It is reported for the first time that up to 99wt.% of sulfur is deposited in the solid residue at 250°C for both solvents. Copyright © 2016 Elsevier Ltd. All rights reserved.

Immunoassay for wheat processing quality: utilization of a sandwich assay incorporating an immobilized single-chain fragment.

PubMed

Hill, A S; Giersch, T M; Loh, C S; Skerritt, J H

1999-10-01

A single-chain fragment (scFv) was engineered from a monoclonal antibody to high molecular weight glutenin subunits (HMW-GS), wheat flour polypeptides that play a major role in determining the mixing- and extension strength-related properties of dough and its subsequent baking performance. The scFv was expressed in a thioredoxin mutant Escherichia coli strain that allows disulfide bond formation in the cytoplasm and incorporated into a diagnostic test for wheat quality. Although the scFv lacks the more highly conserved antibody constant regions usually involved with immobilization, it was able to be directly immobilized to a polystyrene microwell solid phase without chemical or covalent modification of the protein or solid phase and utilized as a capture antibody in a double-antibody (two-site) immunoassay. In the sandwich assay, increasing HMW-GS concentrations produced increasing assay color, and highly significant correlations were obtained between optical densities obtained in the ELISA using the scFv and the content of large glutenin polymers in flours as well as measures of dough strength as measured by resistance to dough extension in rheological testing. The assay using the scFv was able to be carried out at lower flour sample extract dilutions than that required for a similar assay utilizing a monoclonal capture antibody. This research shows that engineered antibody fragments can be utilized to provide superior assay performance in two-site ELISAs over monoclonal antibodies and is the first application of an engineered antibody to the analysis of food processing quality.

78 FR 11803 - Proposed Waiver and Extension of the Project Period for the National Dropout Prevention Center...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-20

...., Washington, DC, between the hours of 8:30 a.m. and 4:00 p.m., Washington, DC time, Monday through Friday of... collection systems to track students at risk of dropping out; and (3) designing training for policymakers... about dropout prevention for students with disabilities, and to develop a series of high-quality...

Local Galaxies as Damped LY-α Analogs

NASA Astrophysics Data System (ADS)

Zwaan, M. A.; van der Hulst, J. M.; Briggs, F. H.; Verheijen, M. A. W.; Ryan-Weber, E. V.

We calculate in detail the expected properties of low redshift DLAs under the assumption that they arise in the gaseous disks of galaxies like those in the z≈0 population. A sample of 355 nearby galaxies is analysed, for which high quality Hi 21-cm emission line maps are available as part of an extensive survey with theWesterbork telescope (WHISP).

Using the Zope Web application framework to build and manage a large encyclopedia of scientific knowledge

Treesearch

John Jordin; William Hubbard; Deborah Kennard; William Milnor; Michael Rauscher; Bryan Veal

2003-01-01

Many social and economic institutions in the Southern Appalachians depend on the various benefits provided by its forests, such as abundant, high-quality timber; plentiful and diverse fish and wildlife; extensive recreational opportunities; and, a variety of nontimber forest products. These benefits take on added value because of their proximity to human population...

Preschool Inclusion: Key Findings from Research and Implications for Policy. Child Care and Early Education Research Connections

ERIC Educational Resources Information Center

Lawrence, Sharmila; Smith, Sheila; Banerjee, Rashida

2016-01-01

A recent policy statement issued by the U.S. Department of Health and Human Services (HHS) and U.S. Department of Education (DOE) on early childhood inclusion presents extensive recommendations for state and local actions that could improve young children's access to high quality inclusive preschool programs (HHS/DOE, 2015). This brief builds on…

On Counting Sheep: The Self-Medication and Coping Strategies of University Students Suffering from Primary Insomnia

ERIC Educational Resources Information Center

Cockcroft, K.; Grasko, D.; Fridjhon, P.

2006-01-01

A factor that affects university students' academic performance is the quantity and quality of their sleep. There is a high rate of insomnia in the general population, but the prevalence of sleep difficulties among university students has not been extensively studied. The current study found that 23 per cent of the researched student population…

Analyzing the Effects of Climate Factors on Soybean Protein, Oil Contents, and Composition by Extensive and High-Density Sampling in China.

PubMed

Song, Wenwen; Yang, Ruping; Wu, Tingting; Wu, Cunxiang; Sun, Shi; Zhang, Shouwei; Jiang, Bingjun; Tian, Shiyan; Liu, Xiaobing; Han, Tianfu

2016-05-25

From 2010 to 2013, 763 soybean samples were collected from an extensive area of China. The correlations between seed compositions and climate data were analyzed. The contents of crude protein and water-soluble protein, total amount of protein plus oil, and most of the amino acids were positively correlated with an accumulated temperature ≥15 °C (AT15) and the mean daily temperature (MDT) but were negatively correlated with hours of sunshine (HS) and diurnal temperature range (DTR). The correlations of crude oil and most fatty acids with climate factors were opposite to those of crude protein. Crude oil content had a quadratic regression relationship with MDT, and a positive correlation between oil content and MDT was found when the daily temperature was <19.7 °C. A path analysis indicated that DTR was the main factor that directly affected soybean protein and oil contents. The study illustrated the effects of climate factors on soybean protein and oil contents and proposed agronomic practices for improving soybean quality in different regions of China. The results provide a foundation for the regionalization of high-quality soybean production in China and similar regions in the world.

Removal of Lattice Imperfections that Impact the Optical Quality of Ti:Sapphire using Advanced Magnetorheological Finishing Techniques

DOE Office of Scientific and Technical Information (OSTI.GOV)

Menapace, J A; Schaffers, K I; Bayramian, A J

2007-10-09

Ti:sapphire has become the premier lasing medium material for use in solid-state femtosecond high-peak power laser systems because of its wide wavelength tuning range. With a tuneable range from 680 to 1100 nm, peaking at 800 nm, Ti:sapphire lasing crystals can easily be tuned to the required pump wavelength and provide very high pump brightness due to their good beam quality and high output power of typically several watts. Femtosecond lasers are used for precision cutting and machining of materials ranging from steel to tooth enamel to delicate heart tissue and high explosives. These ultra-short pulses are too brief tomore » transfer heat or shock to the material being cut, which means that cutting, drilling, and machining occur with virtually no damage to surrounding material. Furthermore, these lasers can cut with high precision, making hairline cuts of less than 100 microns in thick materials along a computer-generated path. Extension of laser output to higher energies is limited by the size of the amplification medium. Yields of high quality large diameter crystals have been constrained by lattice distortions that may appear in the boule limiting the usable area from which high quality optics can be harvested. Lattice distortions affect the transmitted wavefront of these optics which ultimately limits the high-end power output and efficiency of the laser system, particularly when operated in multi-pass mode. To make matters even more complicated, Ti:sapphire is extremely hard (Mohs hardness of 9 with diamond being 10) which makes it extremely difficult to accurately polish using conventional methods without subsurface damage or significant wavefront error. In this presentation, we demonstrate for the first time that Magnetorheological finishing (MRF) can be used to compensate for the lattice distortions in Ti:sapphire by perturbing the transmitted wavefront. The advanced MRF techniques developed allow for precise polishing of the optical inverse of lattice distortions with magnitudes of about 70 nm in optical path difference onto one or both of the optical surfaces to produce high quality optics from otherwise unusable Ti:sapphire crystals. The techniques include interferometric, software, and machine modifications to precisely locate and polish sub-millimeter sites onto the optical surfaces that can not be polished into the optics conventionally. This work may allow extension of Ti:sapphire based systems to peak powers well beyond one petawatt.« less

Extension's Capacity to Deliver Quality Early Childhood Professional Development

ERIC Educational Resources Information Center

Durden, Tonia R.; Mincemoyer, Claudia C.; Gerdes, Jennifer; Lodl, Kathleen

2013-01-01

In recent years much attention has focused on the role of enhancing a teacher's professional knowledge and skills in helping to improve the quality of early care experiences for young children birth-5. In the study reported here, an environmental scan of the early childhood professional development programs offered within the Extension system…

Quality of Extension Advice: A Gendered Case Study from Ghana and Sri Lanka

ERIC Educational Resources Information Center

Lamontagne-Godwin, Julien; Williams, Frances; Bandara, Willoru Mudiyansele Palitha Thilakasiri; Appiah-Kubi, Ziporah

2017-01-01

Purpose: Women farmers have less access to extension services than male farmers, even though they make up almost half of the global agricultural workforce. Gender-focused international development programmes have focused on how ensuring women receive better access to advice. However, the quality of the technical advice and the service women…

Balancing Accession and Retention (Navy Comprehensive Compensation Study)

DTIC Science & Technology

1982-09-01

training graduate of quality type i SEXTE ^. STAYER. the ratio of the number of extensions of less than 1 year to the number of extensions of 1...rating and quality type who appear in LOS 5 can be calculated: ^5ij ELIG li X^^j ELIG]^^^ REUP^j(BMULT.) + X^j^j EXTE^.(BMULTj) + X^^. ELIG]^^ SEXTE ...in the jth rating, EXTEj_j( BMULT.) SEXTE ^. = probability that an eligible individual of quality type i in rating j chooses to extend his

Long-term Cerec 3D chairside bridges milled from IPS e.max CAD LT blocks.

PubMed

Schneider, Oliver

The experienced Cerec user can manufacture high-quality, esthetic anterior and posterior bridges from IPS e.max CAD in a manageable 3-hour chairside session. On the basis of over 8 years of experience, it can be said that these restorations are clinically very well proven, provided they are used within the range of recommended indications. Experimental retainer bridges with extensions can be seen as highly interesting alternatives, although more clinical data are required for further confirmation.

An Analysis of the Priority Needs of Cooperative Extension at the County Level

ERIC Educational Resources Information Center

Harder, Amy; Lamm, Alexa; Strong, Robert

2009-01-01

Cooperative Extension's role as a relevant provider of nonformal education is dependent upon its ability to improve and adjust in response to internal and external pressures. Periodically conducting needs assessments focused on the Extension organization can aid in Extension's efforts to deliver quality educational programs by pinpointing priority…

Analyzing the natural resource extension needs of Spanish-speakers: A perspective from Florida

Treesearch

Miriam Wyman; Francisco Escobedo; Sebastian Varela; Cesar Asuaje; Henry Mayer; Mickie Swisher; Annie Hermansen

2011-01-01

Hispanics are the country's fastest growing minority group. The study reported here surveyed and assessed Extension agents from two demographically different regions in Florida on perceptions and attitudes about the need, quality, and dissemination of Spanish Extension materials. Results showed Extension programs are important sources of information for Spanish-...

The Structured Assessment of Violence Risk in Adults with Intellectual Disability: A Systematic Review.

PubMed

Hounsome, J; Whittington, R; Brown, A; Greenhill, B; McGuire, J

2018-01-01

While structured professional judgement approaches to assessing and managing the risk of violence have been extensively examined in mental health/forensic settings, the application of the findings to people with an intellectual disability is less extensively researched and reviewed. This review aimed to assess whether risk assessment tools have adequate predictive validity for violence in adults with an intellectual disability. Standard systematic review methodology was used to identify and synthesize appropriate studies. A total of 14 studies were identified as meeting the inclusion criteria. These studies assessed the predictive validity of 18 different risk assessment tools, mainly in forensic settings. All studies concluded that the tools assessed were successful in predicting violence. Studies were generally of a high quality. There is good quality evidence that risk assessment tools are valid for people with intellectual disability who offend but further research is required to validate tools for use with people with intellectual disability who offend. © 2016 John Wiley & Sons Ltd.

The state of ambient air quality in Pakistan--a review.

PubMed

Colbeck, Ian; Nasir, Zaheer Ahmad; Ali, Zulfiqar

2010-01-01

Pakistan, during the last decade, has seen an extensive escalation in population growth, urbanization, and industrialization, together with a great increase in motorization and energy use. As a result, a substantial rise has taken place in the types and number of emission sources of various air pollutants. However, due to the lack of air quality management capabilities, the country is suffering from deterioration of air quality. Evidence from various governmental organizations and international bodies has indicated that air pollution is a significant risk to the environment, quality of life, and health of the population. The Government has taken positive steps toward air quality management in the form of the Pakistan Clean Air Program and has recently established a small number of continuous monitoring stations. However, ambient air quality standards have not yet been established. This paper reviews the data being available on the criteria air pollutants: particulate matter (PM), sulfur dioxide, ozone, carbon monoxide, nitrogen dioxide, and lead. Air pollution studies in Pakistan published in both scientific journals and by the Government have been reviewed and the reported concentrations of PM, SO(2), O(3), CO, NO(2), and Pb collated. A comparison of the levels of these air pollutants with the World Health Organization air quality guidelines was carried out. Particulate matter was the most serious air pollutant in the country. NO(2) has emerged as the second high-risk pollutant. The reported levels of PM, SO(2), CO, NO(2), and Pb were many times higher than the World Health Organization air quality guidelines. Only O(3) concentrations were below the guidelines. The current state of air quality calls for immediate action to tackle the poor air quality. The establishment of ambient air quality standards, an extension of the continuous monitoring sites, and the development of emission control strategies are essential.

Spatial Double Generalized Beta Regression Models: Extensions and Application to Study Quality of Education in Colombia

ERIC Educational Resources Information Center

Cepeda-Cuervo, Edilberto; Núñez-Antón, Vicente

2013-01-01

In this article, a proposed Bayesian extension of the generalized beta spatial regression models is applied to the analysis of the quality of education in Colombia. We briefly revise the beta distribution and describe the joint modeling approach for the mean and dispersion parameters in the spatial regression models' setting. Finally, we motivate…

Evaluation of High-Angle-of-Attack Handling Qualities for the X-31A Using Standard Evaluation Maneuvers

NASA Technical Reports Server (NTRS)

Stoliker, Patrick C.; Bosworth, John T.

1996-01-01

The X-31A aircraft gross-acquisition and fine-tracking handling qualities have been evaluated using standard evaluation maneuvers developed by Wright Laboratory, Wright-Patterson Air Force Base. The emphasis of the testing is in the angle-of-attack range between 30 deg and 70 deg. Longitudinal gross-acquisition handling qualities results show borderline Level 1/Level 2 performance. Lateral gross-acquisition testing results in Level 1/Level 2 ratings below 45 deg angle of attack, degrading into Level 3 as angle of attack increases. The fine-tracking performance in both longitudinal and lateral axes also receives Level 1 ratings near 30 deg angle of attack, with the ratings tending towards Level 3 at angles of attack greater than 50 deg. These ratings do not match the expectations from the extensive close-in combat testing where the X-31A aircraft demonstrated fair to good handling qualities maneuvering for high angles of attack. This paper presents the results of the high-angle-of-attack handling qualities flight testing of the X-31A aircraft. Discussion of the preparation for the maneuvers, the pilot ratings, and selected pilot comments are included. Evaluation of the results is made in conjunction with existing Neal-Smith, bandwidth, Smith-Geddes, and military specifications.

Evaluation of High-Angle-of-Attack Handling Qualities for the X-31A Using Standard Evaluation Maneuvers

NASA Technical Reports Server (NTRS)

Stoliker, Patrick C.; Bosworth, John T.

1997-01-01

The X-31A aircraft gross-acquisition and fine-tracking handling qualities have been evaluated using standard evaluation maneuvers developed by Wright Laboratory, Wright Patterson Air Force Base. The emphasis of the testing is in the angle-of-attack range between 30 deg. and 70 deg. Longitudinal gross-acquisition handling qualities results show borderline Level l/Level 2 performance. Lateral gross-acquisition testing results in Level l/Level 2 ratings below 45 deg. angle of attack, degrading into Level 3 as angle of attack increases. The fine tracking performance in both longitudinal and lateral axes also receives Level 1 ratings near 30 deg. angle of attack, with the ratings tending towards Level 3 at angles of attack greater than 50 deg. These ratings do not match the expectations from the extensive close-in combat testing where the X-31A aircraft demonstrated fair to good handling qualities maneuvering for high angles of attack. This paper presents the results of the high-angle-of-attack handling qualities flight testing of the X-31A aircraft. Discussion of the preparation for the maneuvers, the pilot ratings, and selected pilot comments are included. Evaluation of the results is made in conjunction with existing Neal Smith, bandwidth, Smith-Geddes, and military specifications.

Postharvest and sensory evaluation of selected ‘Hass’x‘Bacon’ and ‘Bacon’x ‘Hass’ avocado hybrids grown in East-Central Florida

USDA-ARS?s Scientific Manuscript database

Avocado (Persea americana Mill.) is a high-value fruit that continues to increase in consumer demand. A population of ‘Hass’-‘Bacon’ hybrids was planted at USDA-ARS, Fort Pierce as part of a study to find selections with good horticultural and postharvest quality traits for Florida. Extensive phenot...

Effects of silviculture and genetics on branch/knot attributes of coastal Pacific Northwest Douglas-fir and implications for wood quality--a synthesis

Treesearch

Eini C. Lowell; Douglas A. Maguire; David G. Briggs; Eric C. Turnblom; Keith J.S. Jayawickrama; Jed Bryce

2014-01-01

Douglas-fir is the most commercially important timber species in the US Pacific Northwest due to its ecological prevalence and its superior wood attributes, especially strength and stiffness properties that make it highly prized for structural applications. Its economic significance has led to extensive establishment and management of plantations over the last few...

Principled Design of an Augmented Reality Trainer for Medics

DTIC Science & Technology

2018-04-13

retake test is scheduled. In addition, extensive simulation capstone scenarios are run with a full body manikin that includes airway management...platform so they could run with high quality graphical resolution. We updated the underlying data models to reflect the training scenario parameters...Sedeh, P., Schumann, M., & Groeben, H. (2009). Laryngoscopy via Macintosh blade versus GlideScope: Success rate and time for endotracheal intubation

A winning formula for new laboratories.

PubMed

Robinson, Tim

2012-11-01

High quality architecture and extensive stakeholder consultations have transformed the delivery of Laboratory Medicine within Sheffield Teaching Hospitals NHS Foundation Trust (NHSFT), explains Tim Robinson, senior architect at Race Cottam Associates, the architects on a scheme that has seen laboratory services from across the city consolidated within one modern, spacious, well-lit, and well-equipped building that should provide an extremely positive, 'future-proofed' working environment for staff.

Fuel and fire behavior in high-elevation five-needle pines affected by mountain pine beetle

Treesearch

Michael J. Jenkins

2011-01-01

Bark beetle-caused tree mortality in conifer forests affects the quantity and quality of forest fuels and has long been assumed to increase fire hazard and potential fire behavior. In reality, bark beetles and their effects on fuel accumulation and subsequent fire hazard have only recently been described. We have extensively sampled fuels in three conifer forest types...

Uncertainty analyses of the calibrated parameter values of a water quality model

NASA Astrophysics Data System (ADS)

Rode, M.; Suhr, U.; Lindenschmidt, K.-E.

2003-04-01

For river basin management water quality models are increasingly used for the analysis and evaluation of different management measures. However substantial uncertainties exist in parameter values depending on the available calibration data. In this paper an uncertainty analysis for a water quality model is presented, which considers the impact of available model calibration data and the variance of input variables. The investigation was conducted based on four extensive flowtime related longitudinal surveys in the River Elbe in the years 1996 to 1999 with varying discharges and seasonal conditions. For the model calculations the deterministic model QSIM of the BfG (Germany) was used. QSIM is a one dimensional water quality model and uses standard algorithms for hydrodynamics and phytoplankton dynamics in running waters, e.g. Michaelis Menten/Monod kinetics, which are used in a wide range of models. The multi-objective calibration of the model was carried out with the nonlinear parameter estimator PEST. The results show that for individual flow time related measuring surveys very good agreements between model calculation and measured values can be obtained. If these parameters are applied to deviating boundary conditions, substantial errors in model calculation can occur. These uncertainties can be decreased with an increased calibration database. More reliable model parameters can be identified, which supply reasonable results for broader boundary conditions. The extension of the application of the parameter set on a wider range of water quality conditions leads to a slight reduction of the model precision for the specific water quality situation. Moreover the investigations show that highly variable water quality variables like the algal biomass always allow a smaller forecast accuracy than variables with lower coefficients of variation like e.g. nitrate.

A peptide extension dictates IgM assembly.

PubMed

Pasalic, Dzana; Weber, Benedikt; Giannone, Chiara; Anelli, Tiziana; Müller, Roger; Fagioli, Claudio; Felkl, Manuel; John, Christine; Mossuto, Maria Francesca; Becker, Christian F W; Sitia, Roberto; Buchner, Johannes

2017-10-10

Professional secretory cells can produce large amounts of high-quality complex molecules, including IgM antibodies. Owing to their multivalency, polymeric IgM antibodies provide an efficient first-line of defense against pathogens. To decipher the mechanisms of IgM assembly, we investigated its biosynthesis in living cells and faithfully reconstituted the underlying processes in vitro. We find that a conserved peptide extension at the C-terminal end of the IgM heavy (Ig-μ) chains, termed the tailpiece, is necessary and sufficient to establish the correct geometry. Alanine scanning revealed that hydrophobic amino acids in the first half of the tailpiece contain essential information for generating the correct topology. Assembly is triggered by the formation of a disulfide bond linking two tailpieces. This induces conformational changes in the tailpiece and the adjacent domain, which drive further polymerization. Thus, the biogenesis of large and topologically challenging IgM complexes is dictated by a local conformational switch in a peptide extension.

Institutional and economic influences on the adoption and extensiveness of managerial innovation in hospitals: The case of reengineering.

PubMed

Walston, S L; Kimberly, J R; Burns, L R

2001-06-01

In the recent past, a number of managerial innovations--including product line management, total quality management, and reengineering--have swept through the hospital industry. Given their pervasiveness and their cost, understanding the mix of factors that influences their adoption is of theoretical interest and practical relevance. The research reported here focuses on this general question by examining influences on the adoption and extensiveness of a particular managerial innovation, hospital reengineering. The results suggest that while economic and institutional factors have influenced the adoption and extensiveness of hospital reengineering, institutional forces play a more important role. The greater influence of institutional forces may be attributed to the high degree of uncertainty in health care, the causal ambiguity of the innovation, and the anticipatory actions of hospitals attempting to position themselves in a rapidly changing environment.

Extension of effective date for temporary pilot program setting the time and place for a hearing before an administrative law judge. Final rule.

PubMed

2013-07-29

: We are extending our pilot program that authorizes the agency to set the time and place for a hearing before an administrative law judge (ALJ). This final rule will extend the pilot program for 1 year. The extension of the pilot program continues our commitment to improve the efficiency of our hearing process and maintain a hearing process that results in accurate, high-quality decisions for claimants. The current pilot program will expire on August 9, 2013. In this final rule, we are extending the effective date to August 9, 2014. We are making no other substantive changes.

Small physician practices in new york needed sustained help to realize gains in quality from use of electronic health records.

PubMed

Ryan, Andrew M; Bishop, Tara F; Shih, Sarah; Casalino, Lawrence P

2013-01-01

The 2009 American Recovery and Reinvestment Act spurred adoption of electronic health records (EHRs) in the United States, through such measures as financial incentives to providers through Medicare and Medicaid and regional extension centers, which provide ongoing technical assistance to practices. Yet the relationship between EHR adoption and quality of care remains poorly understood. We evaluated the early effects on quality of the Primary Care Information Project, which provides subsidized EHRs and technical assistance to primary care practices in underserved neighborhoods in New York City, using the regional extension center model. We found that just general participation in, or exposure to, the project was not enough to improve quality of care. It took sustained exposure on the part of these practices and technical assistance to them before they demonstrated improvement on measures of care most likely to be affected by the use of electronic health records, such as cancer screenings and care for patients with diabetes. Participating in the Primary Care Information Project for nine or more months was associated with significantly improved quality, but only for this limited group of quality measures and only for physicians receiving extensive technical assistance.

Carcass and meat quality of Gokceada Goat kids reared under extensive and semi-intensive production systems.

PubMed

Ozcan, Mustafa; Yalcintan, Hulya; Tölü, Cemil; Ekiz, Bulent; Yilmaz, Alper; Savaş, Türker

2014-01-01

The aim was to compare the carcass and meat quality characteristics of male and female Gokceada Goat kids produced in extensive (n=20) and semi-intensive (n=20) systems. In extensive and semi-intensive produced kids pre-slaughter weights were 17.44 and 12.51 kg; cold carcass weights were 8.66 and 5.35 kg and cold dressing percentages were 54.9 and 49.28%, respectively. The effect of kid sex was not significant on hot and cold dressing percentages, back fat thickness, M. longissimus dorsi section area, carcass fatness and conformation scores, and carcass measurements, while female kids had higher omental and mesenteric fat and kidney knob and channel fat percentages than male kids. Extensive produced kids had lower meat lightness. Panellists evaluated extensive system kids with higher scores of kid odour intensity, flavour intensity and overall acceptability. It was concluded that it would be more appropriate to use an extensive system in Gokceada Goat breeding for kid meat production. © 2013.

Assessing Quality of Data Standards: Framework and Illustration Using XBRL GAAP Taxonomy

NASA Astrophysics Data System (ADS)

Zhu, Hongwei; Wu, Harris

The primary purpose of data standards or metadata schemas is to improve the interoperability of data created by multiple standard users. Given the high cost of developing data standards, it is desirable to assess the quality of data standards. We develop a set of metrics and a framework for assessing data standard quality. The metrics include completeness and relevancy. Standard quality can also be indirectly measured by assessing interoperability of data instances. We evaluate the framework using data from the financial sector: the XBRL (eXtensible Business Reporting Language) GAAP (Generally Accepted Accounting Principles) taxonomy and US Securities and Exchange Commission (SEC) filings produced using the taxonomy by approximately 500 companies. The results show that the framework is useful and effective. Our analysis also reveals quality issues of the GAAP taxonomy and provides useful feedback to taxonomy users. The SEC has mandated that all publicly listed companies must submit their filings using XBRL. Our findings are timely and have practical implications that will ultimately help improve the quality of financial data.

Tracing the influence of land-use change on water quality and coral reefs using a Bayesian model.

PubMed

Brown, Christopher J; Jupiter, Stacy D; Albert, Simon; Klein, Carissa J; Mangubhai, Sangeeta; Maina, Joseph M; Mumby, Peter; Olley, Jon; Stewart-Koster, Ben; Tulloch, Vivitskaia; Wenger, Amelia

2017-07-06

Coastal ecosystems can be degraded by poor water quality. Tracing the causes of poor water quality back to land-use change is necessary to target catchment management for coastal zone management. However, existing models for tracing the sources of pollution require extensive data-sets which are not available for many of the world's coral reef regions that may have severe water quality issues. Here we develop a hierarchical Bayesian model that uses freely available satellite data to infer the connection between land-uses in catchments and water clarity in coastal oceans. We apply the model to estimate the influence of land-use change on water clarity in Fiji. We tested the model's predictions against underwater surveys, finding that predictions of poor water quality are consistent with observations of high siltation and low coverage of sediment-sensitive coral genera. The model thus provides a means to link land-use change to declines in coastal water quality.

Tailoring recombinant protein quality by rational media design.

PubMed

Brühlmann, David; Jordan, Martin; Hemberger, Jürgen; Sauer, Markus; Stettler, Matthieu; Broly, Hervé

2015-01-01

Clinical efficacy and safety of recombinant proteins are closely associated with their structural characteristics. The major quality attributes comprise glycosylation, charge variants (oxidation, deamidation, and C- & N-terminal modifications), aggregates, low-molecular-weight species (LMW), and misincorporation of amino acids in the protein backbone. Cell culture media design has a great potential to modulate these quality attributes due to the vital role of medium in mammalian cell culture. The purpose of this review is to provide an overview of the way both classical cell culture medium components and novel supplements affect the quality attributes of recombinant therapeutic proteins expressed in mammalian hosts, allowing rational and high-throughput optimization of mammalian cell culture media. A selection of specific and/or potent inhibitors and activators of oligosaccharide processing as well as components affecting multiple quality attributes are presented. Extensive research efforts in this field show the feasibility of quality engineering through media design, allowing to significantly modulate the protein function. © 2015 American Institute of Chemical Engineers.

Southern Extension Water Training Workshop: Actions for Working Together. Proceedings of a Regional Conference (Birmingham, Alabama, November 13-15, 1989).

ERIC Educational Resources Information Center

Southern Rural Development Center, Mississippi State, MS.

A training workshop for Southern Extension faculty and staff addressed aspects of water quality and related issues. Conference papers discussed: (1) basic information on hydrology--the science of water transport through the natural environment; (2) sources and impacts of water pollution; (3) the role of public policy in water quality protection;…

Nanoheteroepitaxy of gallium arsenide on strain-compliant silicon-germanium nanowires

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chin, Hock-Chun; Gong, Xiao; Yeo, Yee-Chia

Heterogeneous integration of high-quality GaAs on Si-based substrates using a selective migration-enhanced epitaxy (MEE) of GaAs on strain-compliant SiGe nanowires was demonstrated for the first time. The physics of compliance in nanoscale heterostructures was captured and studied using finite-element simulation. It is shown that nanostructures can provide additional substrate compliance for strain relief and therefore contribute to the formation of defect-free GaAs on SiGe. Extensive characterization using scanning electron microscopy and cross-sectional transmission electron microscopy was performed to illustrate the successful growth of GaAs on SiGe nanowire. Raman and Auger electron spectroscopy measurements further confirmed the quality of the GaAsmore » grown and the high growth selectivity of the MEE process.« less

Challenges in the quality assurance of elemental and isotopic analyses in the nuclear domain benefitting from high resolution ICP-OES and sector field ICP-MS.

PubMed

Krachler, Michael; Alvarez-Sarandes, Rafael; Van Winckel, Stefaan

Accurate analytical data reinforces fundamentally the meaningfulness of nuclear fuel performance assessments and nuclear waste characterization. Regularly lacking matrix-matched certified reference materials, quality assurance of elemental and isotopic analysis of nuclear materials remains a challenging endeavour. In this context, this review highlights various dedicated experimental approaches envisaged at the European Commission-Joint Research Centre-Institute for Transuranium Elements to overcome this limitation, mainly focussing on the use of high resolution-inductively coupled plasma-optical emission spectrometry (HR-ICP-OES) and sector field-inductively coupled plasma-mass spectrometry (SF-ICP-MS). However, also α- and γ-spectrometry are included here to help characterise extensively the investigated actinide solutions for their actual concentration, potential impurities and isotopic purity.

Experimental Investigation – Magnetic Assisted Electro Discharge Machining

NASA Astrophysics Data System (ADS)

Kesava Reddy, Chirra; Manzoor Hussain, M.; Satyanarayana, S.; Krishna, M. V. S. Murali

2018-04-01

Emerging technology needs advanced machined parts with high strength and temperature resistance, high fatigue life at low production cost with good surface quality to fit into various industrial applications. Electro discharge machine is one of the extensively used machines to manufacture advanced machined parts which cannot be machined by other traditional machine with high precision and accuracy. Machining of DIN 17350-1.2080 (High Carbon High Chromium steel), using electro discharge machining has been discussed in this paper. In the present investigation an effort is made to use permanent magnet at various positions near the spark zone to improve surface quality of the machined surface. Taguchi methodology is used to obtain optimal choice for each machining parameter such as peak current, pulse duration, gap voltage and Servo reference voltage etc. Process parameters have significant influence on machining characteristics and surface finish. Improvement in surface finish is observed when process parameters are set at optimum condition under the influence of magnetic field at various positions.

Effect of process parameters on formability of laser melting deposited 12CrNi2 alloy steel

NASA Astrophysics Data System (ADS)

Peng, Qian; Dong, Shiyun; Kang, Xueliang; Yan, Shixing; Men, Ping

2018-03-01

As a new rapid prototyping technology, the laser melting deposition technology not only has the advantages of fast forming, high efficiency, but also free control in the design and production chain. Therefore, it has drawn extensive attention from community.With the continuous improvement of steel performance requirements, high performance low-carbon alloy steel is gradually integrated into high-tech fields such as aerospace, high-speed train and armored equipment.However, it is necessary to further explore and optimize the difficult process of laser melting deposited alloy steel parts to achieve the performance and shape control.This article took the orthogonal experiment on alloy steel powder by laser melting deposition ,and revealed the influence rule of the laser power, scanning speed, powder gas flow on the quality of the sample than the dilution rate, surface morphology and microstructure analysis were carried out.Finally, under the optimum technological parameters, the Excellent surface quality of the alloy steel forming part with high density, no pore and cracks was obtained.

Gunshot-induced fractures of the extremities: a review of antibiotic and debridement practices.

PubMed

Sathiyakumar, Vasanth; Thakore, Rachel V; Stinner, Daniel J; Obremskey, William T; Ficke, James R; Sethi, Manish K

2015-09-01

The use of antibiotic prophylaxis and debridement is controversial when treating low- and high-velocity gunshot-induced fractures, and established treatment guidelines are currently unavailable. The purpose of this review was to evaluate the literature for the prophylactic antibiotic and debridement policies for (1) low-velocity gunshot fractures of the extremities, joints, and pelvis and (2) high-velocity gunshot fractures of the extremities. Low-velocity gunshot fractures of the extremities were subcategorized into operative and non-operative cases, whereas low-velocity gunshot fractures of the joints and pelvis were evaluated based on the presence or absence of concomitant bowel injury. In the absence of surgical necessity for fracture care such as concomitant absence of gross wound contamination, vascular injury, large soft-tissue defect, or associated compartment syndrome, the literature suggests that superficial debridement for low-velocity ballistic fractures with administration of antibiotics is a satisfactory alternative to extensive operative irrigation and debridement. In operative cases or those involving bowel injuries secondary to pelvic fractures, the literature provides support for and against extensive debridement but does suggest the use of intravenous antibiotics. For high-velocity ballistic injuries, the literature points towards the practice of extensive immediate debridement with prophylactic intravenous antibiotics. Our systematic review demonstrates weak evidence for superficial debridement of low-velocity ballistic fractures, extensive debridement for high-velocity ballistic injuries, and antibiotic use for both types of injury. Intra-articular fractures seem to warrant debridement, while pelvic fractures with bowel injury have conflicting evidence for debridement but stronger evidence for antibiotic use. Given a relatively low number of studies on this subject, we recommend that further high-quality research on the debridement and antibiotic use for gunshot-induced fractures of the extremities should be conducted before definitive recommendations and guidelines are developed.

A quality by design approach to scale-up of high-shear wet granulation process.

PubMed

Pandey, Preetanshu; Badawy, Sherif

2016-01-01

High-shear wet granulation is a complex process that in turn makes scale-up a challenging task. Scale-up of high-shear wet granulation process has been studied extensively in the past with various different methodologies being proposed in the literature. This review article discusses existing scale-up principles and categorizes the various approaches into two main scale-up strategies - parameter-based and attribute-based. With the advent of quality by design (QbD) principle in drug product development process, an increased emphasis toward the latter approach may be needed to ensure product robustness. In practice, a combination of both scale-up strategies is often utilized. In a QbD paradigm, there is also a need for an increased fundamental and mechanistic understanding of the process. This can be achieved either by increased experimentation that comes at higher costs, or by using modeling techniques, that are also discussed as part of this review.

SPACEWAY: Providing affordable and versatile communication solutions

NASA Astrophysics Data System (ADS)

Fitzpatrick, E. J.

1995-08-01

By the end of this decade, Hughes' SPACEWAY network will provide the first interactive 'bandwidth on demand' communication services for a variety of applications. High quality digital voice, interactive video, global access to multimedia databases, and transborder workgroup computing will make SPACEWAY an essential component of the computer-based workplace of the 21st century. With relatively few satellites to construct, insure, and launch -- plus extensive use of cost-effective, tightly focused spot beams on the world's most populated areas -- the high capacity SPACEWAY system can pass its significant cost savings onto its customers. The SPACEWAY network is different from other proposed global networks in that its geostationary orbit location makes it a truly market driven system: each satellite will make available extensive telecom services to hundreds of millions of people within the continuous view of that satellite, providing immediate capacity within a specific region of the world.

SPACEWAY: Providing affordable and versatile communication solutions

NASA Technical Reports Server (NTRS)

Fitzpatrick, E. J.

1995-01-01

By the end of this decade, Hughes' SPACEWAY network will provide the first interactive 'bandwidth on demand' communication services for a variety of applications. High quality digital voice, interactive video, global access to multimedia databases, and transborder workgroup computing will make SPACEWAY an essential component of the computer-based workplace of the 21st century. With relatively few satellites to construct, insure, and launch -- plus extensive use of cost-effective, tightly focused spot beams on the world's most populated areas -- the high capacity SPACEWAY system can pass its significant cost savings onto its customers. The SPACEWAY network is different from other proposed global networks in that its geostationary orbit location makes it a truly market driven system: each satellite will make available extensive telecom services to hundreds of millions of people within the continuous view of that satellite, providing immediate capacity within a specific region of the world.

Mesh quality oriented 3D geometric vascular modeling based on parallel transport frame.

PubMed

Guo, Jixiang; Li, Shun; Chui, Yim Pan; Qin, Jing; Heng, Pheng Ann

2013-08-01

While a number of methods have been proposed to reconstruct geometrically and topologically accurate 3D vascular models from medical images, little attention has been paid to constantly maintain high mesh quality of these models during the reconstruction procedure, which is essential for many subsequent applications such as simulation-based surgical training and planning. We propose a set of methods to bridge this gap based on parallel transport frame. An improved bifurcation modeling method and two novel trifurcation modeling methods are developed based on 3D Bézier curve segments in order to ensure the continuous surface transition at furcations. In addition, a frame blending scheme is implemented to solve the twisting problem caused by frame mismatch of two successive furcations. A curvature based adaptive sampling scheme combined with a mesh quality guided frame tilting algorithm is developed to construct an evenly distributed, non-concave and self-intersection free surface mesh for vessels with distinct radius and high curvature. Extensive experiments demonstrate that our methodology can generate vascular models with better mesh quality than previous methods in terms of surface mesh quality criteria. Copyright © 2013 Elsevier Ltd. All rights reserved.

Evaluation of the structural, physicochemical, and biological characteristics of SB4, a biosimilar of etanercept

PubMed Central

Cho, Ick Hyun; Lee, Nayoung; Song, Dami; Jung, Seong Young; Bou-Assaf, George; Sosic, Zoran; Zhang, Wei; Lyubarskaya, Yelena

2016-01-01

ABSTRACT A biosimilar is a biological medicinal product that is comparable to a reference medicinal product in terms of quality, safety, and efficacy. SB4 was developed as a biosimilar to Enbrel® (etanercept) and was approved as Benepali®, the first biosimilar of etanercept licensed in the European Union (EU). The quality assessment of SB4 was performed in accordance with the ICH comparability guideline and the biosimilar guidelines of the European Medicines Agency and Food and Drug Administration. Extensive structural, physicochemical, and biological testing was performed with state-of-the-art technologies during a side-by-side comparison of the products. Similarity of critical quality attributes (CQAs) was evaluated on the basis of tolerance intervals established from quality data obtained from more than 60 lots of EU-sourced and US-sourced etanercept. Additional quality assessment was focused on a detailed investigation of immunogenicity-related quality attributes, including hydrophobic variants, high-molecular-weight (HMW) species, N-glycolylneuraminic acid (NGNA), and α-1,3-galactose. This comprehensive characterization study demonstrated that SB4 is highly similar to the reference product, Enbrel®, in structural, physicochemical, and biological quality attributes. In addition, the levels of potential immunogenicity-related quality attributes of SB4 such as hydrophobic variants, HMW aggregates, and α-1,3-galactose were less than those of the reference product. PMID:27246928

During a winter of storms in a small UK catchment, hydrology and water quality responses follow a clear rural-urban gradient

NASA Astrophysics Data System (ADS)

McGrane, Scott J.; Hutchins, Michael G.; Miller, James D.; Bussi, Gianbattista; Kjeldsen, Thomas R.; Loewenthal, Matt

2017-02-01

This paper presents the hydrological and water quality response from a series of extreme storm events that passed across the UK during the winter of 2013/2014, in an experimental catchment with a strong rural-urban gradient across four nested sub-catchment areas. The Ray catchment in the upper Thames basin, UK, was extensively monitored using in-situ, high-resolution (15 min) flow and water quality instrumentation. Dissolved oxygen, ammonium, turbidity and specific conductivity are used to characterise the water quality dynamics. The impact of the Swindon sewage treatment works (SSTW) on water chemistry at the catchment outlet is considerable. Hydrological and water-quality response varies considerably during the events, with the rural catchments exhibiting a much slower hydrological response compared to urban areas. A simple hydrological model (TETIS) was developed to provide insight into water sources in nested subcatchments, highlighting the disparity of the hydrological dynamics across contrasting land-uses during events. The variation in stormwater runoff sources impacts water quality signals with urban sites contributing to dilution dynamics in ammonium, whereas the more rural site experiences a peak in ammonium during the same event. Dissolved oxygen concentrations vary on a rural-urban gradient and experience a notable sag at the Water Eaton outlet (4.4 mg/l) during the events, that would have resulted in significant ecological harm had they occurred during the summer in warmer temperatures. The water-quality legacy of these storms in the wider context of the hydrological year is somewhat negligible, with markedly poorer water quality signals being observed during the summer months of 2014. Although ammonium concentrations during the events are elevated (above the 'good' status threshold under the WFD), higher values are observed during spring and summer months. The high flows actually appear to flush contaminants out of the Ray and its subcatchments, though the urban sites demonstrate a resupply dynamic during interim dry periods. Data suggest winter storms following dry spells in urban catchments cause some short-lived and spatially extensive deteriorations in water quality. More chronic effects, although prolonged, are only seen downstream of SSTW. These are indicative of capacity of infrastructure being reached, and from the data do not appear to be severe enough to cause ecological harm.

Meraculous2

DOE Office of Scientific and Technical Information (OSTI.GOV)

2014-06-01

meraculous2 is a whole genome shotgun assembler for short-reads that is capable of assembling large, polymorphic genomes with modest computational requirements. Meraculous relies on an efficient and conservative traversal of the subgraph of the k-mer (deBruijn) graph of oligonucleotides with unique high quality extensions in the dataset, avoiding an explicit error correction step as used in other short-read assemblers. Additional features include (1) handling of allelic variation using "bubble" structures within the deBruijn graph, (2) gap closing of repetitive and low quality regions using localized assemblies, and (3) an improved scaffolding algorithm that produces more complete assemblies without compromising onmore » scaffolding accuracy« less

Diagnostic imaging of trabecular bone microstructure for oral implants: a literature review.

PubMed

Ibrahim, N; Parsa, A; Hassan, B; van der Stelt, P; Wismeijer, D

2013-01-01

Several dental implant studies have reported that radiographic evaluation of bone quality can aid in reducing implant failure. Bone quality is assessed in terms of its quantity, density, trabecular characteristics and cells. Current imaging modalities vary widely in their efficiency in assessing trabecular structures, especially in a clinical setting. Most are very costly, require an extensive scanning procedure coupled with a high radiation dose and are only partially suitable for patient use. This review examines the current literature regarding diagnostic imaging assessment of trabecular microstructure prior to oral implant placement and suggests cone beam CT as a method of choice for evaluating trabecular bone microstructure.

Unfulfilled Promise: Ensuring High Quality Teachers for Our Nation's Students. No Child Left Behind: A Status Report from Southeastern Schools. Extensive Findings

ERIC Educational Resources Information Center

Southeast Center for Teaching Quality, 2004

2004-01-01

Since the reauthorization of the Elementary and Secondary Education Act or the No Child Left Behind Act (NCLB) of 2001, much has been said and written about the law by a variety of education observers, practitioners, and policymakers from both sides of the political aisle. With support from the Ford, Rockefeller, and Z. Smith Reynolds foundations,…

Mesozoic and Cenozoic structural evolution of North Oman: New insights from high-quality 3D seismic from the Lekhwair area

NASA Astrophysics Data System (ADS)

Bazalgette, Loïc; Salem, Hisham

2018-06-01

This paper highlights the role of Triassic-Jurassic extension and late Cretaceous compression in the Mesozoic-Cenozoic (Alpine) structuring of North Oman. The syn/post-Mesozoic regional structural evolution is usually documented as a succession of two stages of deformation. The Alpine 1 phase, late Cretaceous in age, occurred in association with two ophiolite obduction stages (Semail and Masirah ophiolites). It was characterised by strike slip to extensional deformation in the North Oman foreland basin sub-surface. The Alpine 2 phase, Miocene in age, was related to the continental collision responsible for both the Zagros orogen and the uplift of the Oman Mountains. The Alpine 2 deformation was transpressional to compressional. Observation and interpretation of good quality 3D seismic in the Lekhwair High area enabled the distinction of two earlier phases. Early Mesozoic extension occurred concomitantly with the regional Triassic to Jurassic rifting, developing Jurassic-age normal faults. Late Cretaceous compression occurred prior to the main Alpine 1 phase and triggered the inversion of Jurassic-seated normal faults as well as the initiation of compressional folds in the Cretaceous overburden. These early phases have been ignored or overlooked as part of the North Oman history although they are at the origin of structures hosting major local and regional hydrocarbon accumulations.

Influence of land use on the quantity and quality of runoff along Israel's coastal strip

NASA Astrophysics Data System (ADS)

Goldshleger, Naftaly; Asaf, Lior; Maor, Alon; Garzuzi, Jamil Jamil

2013-04-01

This study presents an analysis of the quantity and quality of urban runoff from various land uses by remote-sensing and GIS technology coupled with hydrological and chemical monitoring. The study areas were located in the cities of Herzliya and Ra'anana, in Israel's coastal plain, where extensive urbanization has taken place over the last 30 years. Land uses in urban basins were analyzed; rain and runoff were measured and sampled at measurement stations representing different land uses (residential, industrial, commercial, roads, gas station). The aim was to analyze land uses by different remote-sensing and GIS techniques, to evaluate the quality and quantity of urban storm water from various land uses, and to verify a method for predicting the impact of urban land uses on quantity and quality of urban storm water. The quality of urban storm water from residential areas was generally very high, and the water is suitable for reuse or direct recharge into the local aquifer. In light of the serious state of the Israeli water sector and the large amounts of unused runoff produced by Israel's cities, together with the high quality of urban storm water drained from the residential areas, it is important to exploit this water source

A Pilot Cost-Effectiveness Analysis of Treatments in Newly Diagnosed High-Grade Gliomas: The Example of 5-Aminolevulinic Acid Compared With White-Light Surgery

PubMed Central

Alves, Marta; Castel-Branco, Marta; Stummer, Walter

2015-01-01

BACKGROUND: High-grade gliomas are aggressive, incurable tumors characterized by extensive diffuse invasion of the normal brain parenchyma. Novel therapies at best prolong survival; their costs are formidable and benefit is marginal. Economic restrictions thus require knowledge of the cost-effectiveness of treatments. Here, we show the cost-effectiveness of enhanced resections in malignant glioma surgery using a well-characterized tool for intraoperative tumor visualization, 5-aminolevulinic acid (5-ALA). OBJECTIVE: To evaluate the cost-effectiveness of 5-ALA fluorescence-guided neurosurgery compared with white-light surgery in adult patients with newly diagnosed high-grade glioma, adopting the perspective of the Portuguese National Health Service. METHODS: We used a Markov model (cohort simulation). Transition probabilities were estimated with the use of data from 1 randomized clinical trial and 1 noninterventional prospective study. Utility values and resource use were obtained from published literature and expert opinion. Unit costs were taken from official Portuguese reimbursement lists (2012 values). The health outcomes considered were quality-adjusted life-years, life-years, and progression-free life-years. Extensive 1-way and probabilistic sensitivity analyses were performed. RESULTS: The incremental cost-effectiveness ratios are below €10 000 in all evaluated outcomes, being around €9100 per quality-adjusted life-year gained, €6700 per life-year gained, and €8800 per progression-free life-year gained. The probability of 5-ALA fluorescence-guided surgery cost-effectiveness at a threshold of €20000 is 96.0% for quality-adjusted life-year, 99.6% for life-year, and 98.8% for progression-free life-year. CONCLUSION: 5-ALA fluorescence-guided surgery appears to be cost-effective in newly diagnosed high-grade gliomas compared with white-light surgery. This example demonstrates cost-effectiveness analyses for malignant glioma surgery to be feasible on the basis of existing data. ABBREVIATIONS: 5-ALA, 5-aminolevulinic acid ICER, incremental cost-effectiveness ratio LY, life-year PFLY, progression-free life-year QALY, quality-adjusted life-year PMID:25714513

Building high-quality assay libraries for targeted analysis of SWATH MS data.

PubMed

Schubert, Olga T; Gillet, Ludovic C; Collins, Ben C; Navarro, Pedro; Rosenberger, George; Wolski, Witold E; Lam, Henry; Amodei, Dario; Mallick, Parag; MacLean, Brendan; Aebersold, Ruedi

2015-03-01

Targeted proteomics by selected/multiple reaction monitoring (S/MRM) or, on a larger scale, by SWATH (sequential window acquisition of all theoretical spectra) MS (mass spectrometry) typically relies on spectral reference libraries for peptide identification. Quality and coverage of these libraries are therefore of crucial importance for the performance of the methods. Here we present a detailed protocol that has been successfully used to build high-quality, extensive reference libraries supporting targeted proteomics by SWATH MS. We describe each step of the process, including data acquisition by discovery proteomics, assertion of peptide-spectrum matches (PSMs), generation of consensus spectra and compilation of MS coordinates that uniquely define each targeted peptide. Crucial steps such as false discovery rate (FDR) control, retention time normalization and handling of post-translationally modified peptides are detailed. Finally, we show how to use the library to extract SWATH data with the open-source software Skyline. The protocol takes 2-3 d to complete, depending on the extent of the library and the computational resources available.

Evaluation of green roof as green technology for urban stormwater quantity and quality controls

NASA Astrophysics Data System (ADS)

Kok, K. H.; Sidek, L. M.; Abidin, M. R. Z.; Basri, H.; Muda, Z. C.; Beddu, S.

2013-06-01

Promoting green design, construction, reconstruction and operation of buildings has never been more critical than now due to the ever increasing greenhouse gas emissions and rapid urbanizations that are fuelling climate change more quickly. Driven by environmental needs, Green Building Index (GBI) was founded in Malaysia to drive initiative to lead the property industry towards becoming more environment-friendly. Green roof system is one of the assessment criteria of this rating system which is under category of sustainable site planning and management. An extensive green roof was constructed in Humid Tropics Center (HTC) Kuala Lumpur as one of the components for Stormwater Management Ecohydrology (SME) in order to obtain scientific data of the system. This paper evaluates the performance of extensive green roof at Humid Tropics Center with respect to urban heat island mitigation and stormwater quantity and quality controls. Findings indicate that there was a reduction of around 1.5°C for indoor temperature of the building after installation of green roof. Simulations showed that the peak discharge was reduced up to 24% relative to impervious brown roof. The results show an increment of pH and high concentration of phosphate for the runoff generated from the green roof and the runoff water quality ranged between class I and II under INWQS.

Network-aware scalable video monitoring system for emergency situations with operator-managed fidelity control

NASA Astrophysics Data System (ADS)

Al Hadhrami, Tawfik; Nightingale, James M.; Wang, Qi; Grecos, Christos

2014-05-01

In emergency situations, the ability to remotely monitor unfolding events using high-quality video feeds will significantly improve the incident commander's understanding of the situation and thereby aids effective decision making. This paper presents a novel, adaptive video monitoring system for emergency situations where the normal communications network infrastructure has been severely impaired or is no longer operational. The proposed scheme, operating over a rapidly deployable wireless mesh network, supports real-time video feeds between first responders, forward operating bases and primary command and control centers. Video feeds captured on portable devices carried by first responders and by static visual sensors are encoded in H.264/SVC, the scalable extension to H.264/AVC, allowing efficient, standard-based temporal, spatial, and quality scalability of the video. A three-tier video delivery system is proposed, which balances the need to avoid overuse of mesh nodes with the operational requirements of the emergency management team. In the first tier, the video feeds are delivered at a low spatial and temporal resolution employing only the base layer of the H.264/SVC video stream. Routing in this mode is designed to employ all nodes across the entire mesh network. In the second tier, whenever operational considerations require that commanders or operators focus on a particular video feed, a `fidelity control' mechanism at the monitoring station sends control messages to the routing and scheduling agents in the mesh network, which increase the quality of the received picture using SNR scalability while conserving bandwidth by maintaining a low frame rate. In this mode, routing decisions are based on reliable packet delivery with the most reliable routes being used to deliver the base and lower enhancement layers; as fidelity is increased and more scalable layers are transmitted they will be assigned to routes in descending order of reliability. The third tier of video delivery transmits a high-quality video stream including all available scalable layers using the most reliable routes through the mesh network ensuring the highest possible video quality. The proposed scheme is implemented in a proven simulator, and the performance of the proposed system is numerically evaluated through extensive simulations. We further present an in-depth analysis of the proposed solutions and potential approaches towards supporting high-quality visual communications in such a demanding context.

Optimal early active mobilisation protocol after extensor tendon repairs in zones V and VI: A systematic review of literature.

PubMed

Collocott, Shirley Jf; Kelly, Edel; Ellis, Richard F

2018-03-01

Early mobilisation protocols after repair of extensor tendons in zone V and VI provide better outcomes than immobilisation protocols. This systematic review investigated different early active mobilisation protocols used after extensor tendon repair in zone V and VI. The purpose was to determine whether any one early active mobilisation protocol provides superior results. An extensive literature search was conducted to identify articles investigating the outcomes of early active mobilisation protocols after extensor tendon repair in zone V and VI. Databases searched were AMED, Embase, Medline, Cochrane and CINAHL. Studies were included if they involved participants with extensor tendon repairs in zone V and VI in digits 2-5 and described a post-operative rehabilitation protocol which allowed early active metacarpophalangeal joint extension. Study designs included were randomised controlled trials, observational studies, cohort studies and case series. The Structured Effectiveness Quality Evaluation Scale was used to evaluate the methodological quality of the included studies. Twelve articles met the inclusion criteria. Two types of early active mobilisation protocols were identified: controlled active motion protocols and relative motion extension splinting protocols. Articles describing relative motion extension splinting protocols were more recent but of lower methodological quality than those describing controlled active motion protocols. Participants treated with controlled active motion and relative motion extension splinting protocols had similar range of motion outcomes, but those in relative motion extension splinting groups returned to work earlier. The evidence reviewed suggested that relative motion extension splinting protocols may allow an earlier return to function than controlled active motion protocols without a greater risk of complication.

Persistent Influences of the 2002 Hayman Fire on Stream Nitrate and Dissolved Organic Carbon

NASA Astrophysics Data System (ADS)

Rhoades, C.; Pierson, D. N.; Fegel, T. S., II; Chow, A. T.; Covino, T. P.

2016-12-01

Large, high severity wildfires alter the physical and biological conditions that determine how watersheds retain and release nutrients and regulate stream water quality. For five years after the 2002 Hayman Fire burned in Colorado conifer forests, stream nitrate concentrations and export increased steadily in watersheds with extensive high-severity burning. Stream temperature and turbidity also increased in relation to the extent of high-severity burning and remained elevated above background levels throughout the initial five year post-fire period. Our recent sampling documents that 14 years after the Hayman Fire stream nitrate remains an order of magnitude higher in extensively-burned (35-90%) compared to unburned watersheds (0.2 vs 2.8 mg L-1). Nitrate represents 83% of the total dissolved N in extensively-burned watersheds compared to 29% in unburned watersheds. In contrast, dissolved organic carbon (DOC), was highest in watersheds that burned to a moderate extent (10-20%) and lowest in those with extensive burning. Catchments with a moderate extent burned had DOC concentrations 2.5 and 1.7 times more than those with extensive burning and unburned catchments, respectively. Peak concentrations of DOC and nitrate track the rising limb of the streamflow hydrograph and reach a maximum in May, but patterns among burn extent categories were seasonally consistent. Current riparian conditions are linked to stream nitrate in burned watersheds. For example, stream nitrate increases proportionally to the extent of riparian zones with low shrub cover (R2 = 0.76). We found signs of watershed recovery compared to the initial post-fire period; stream temperature and turbidity remained elevated in extensively burned catchments, but increases were only significant during the spring season. The persistent stream nitrate concentrations as well as the relation between riparian cover and post-fire stream nitrate may help prioritize restoration planting efforts and mitigate chronic, elevated nitrate export from burned watersheds.

High-quality imaging in environmental scanning electron microscopy--optimizing the pressure limiting system and the secondary electron detection of a commercially available ESEM.

PubMed

Fitzek, H; Schroettner, H; Wagner, J; Hofer, F; Rattenberger, J

2016-04-01

In environmental scanning electron microscopy applications in the kPa regime are of increasing interest for the investigation of wet and biological samples, because neither sample preparation nor extensive cooling are necessary. Unfortunately, the applications are limited by poor image quality. In this work the image quality at high pressures of a FEI Quanta 600 (field emission gun) and a FEI Quanta 200 (thermionic gun) is greatly improved by optimizing the pressure limiting system and the secondary electron (SE) detection system. The scattering of the primary electron beam strongly increases with pressure and thus the image quality vanishes. The key to high-image quality at high pressures is to reduce scattering as far as possible while maintaining ideal operation conditions for the SE-detector. The amount of scattering is reduced by reducing both the additional stagnation gas thickness (aSGT) and the environmental distance (ED). A new aperture holder is presented that significantly reduces the aSGT while maintaining the same field-of-view (FOV) as the original design. With this aperture holder it is also possible to make the aSGT even smaller at the expense of a smaller FOV. A new blade-shaped SE-detector is presented yielding better image quality than usual flat SE-detectors. The electrode of the new SE detector is positioned on the sample table, which allows the SE-detector to operate at ideal conditions regardless of pressure and ED. © 2015 The Authors Journal of Microscopy © 2015 Royal Microscopical Society.

Evaluating the message or the messenger? Implications for self-validation in persuasion.

PubMed

Clark, Jason K; Wegener, Duane T; Sawicki, Vanessa; Petty, Richard E; Briñol, Pablo

2013-12-01

Characteristics of persuasive message sources have been extensively studied. However, little attention has been paid to situations when people are motivated to form an evaluation of the communicator rather than the communicated issue. We postulated that these different foci can affect how a source validates message-related cognitions. Participants focused on the source (Studies 1 and 2) or the issue (Study 2) while reading weak or strong message arguments. Later, the communicator was described as low or high in credibility. When focused on the source, highly motivated participants were more confident and their attitudes were more reflective of thoughts when argument quality matched (e.g., weak arguments-low credibility) rather than mismatched (e.g., weak arguments-high credibility) source credibility. Conversely, when participants were focused on the issue, self-validation was greater when credibility was high rather than low-regardless of argument quality. Implications of these findings for the study and practice of persuasion are discussed.

Factors associated with sleep quality among operating engineers.

PubMed

Choi, Seung Hee; Terrell, Jeffrey E; Pohl, Joanne M; Redman, Richard W; Duffy, Sonia A

2013-06-01

Blue collar workers generally report high job stress and are exposed to loud noises at work and engage in many of risky health behavioral factors, all of which have been associated with poor sleep quality. However, sleep quality of blue collar workers has not been studied extensively, and no studies have focused Operating Engineers (heavy equipment operators) among whom daytime fatigue would place them at high risk for accidents. Therefore, the purpose of this study was to determine variables associated with sleep quality among Operating Engineers. This was a cross-sectional survey design with a dependent variable of sleep quality and independent variables of personal and related health behavioral factors. A convenience sample of 498 Operating Engineers was recruited from approximately 16,000 Operating Engineers from entire State of Michigan in 2008. Linear regression was used to determine personal and related health behavior factors associated with sleep quality. Multivariate analyses showed that personal factors related to poor sleep quality were younger age, female sex, higher pain, more medical comorbidities and depressive symptoms and behavioral factors related to poor sleep quality were nicotine dependence. While sleep scores were similar to population norms, approximately 34 % (n = 143) showed interest in health services for sleep problems. While many personal factors are not changeable, interventions to improve sleep hygiene as well as interventions to treat pain, depression and smoking may improve sleep quality resulting in less absenteeism, fatal work accidents, use of sick leave, work disability, medical comorbidities, as well as subsequent mortality.

Factors Associated With Sleep Quality Among Operating Engineers

PubMed Central

Choi, Seung Hee; Terrell, Jeffrey E.; Pohl, Joanne M.; Redman, Richard W.

2016-01-01

Blue collar workers generally report high job stress and are exposed to loud noises at work and engage in many of the health behavioral factors, all of which have been associated with poor sleep quality. However, sleep quality of blue collar workers has not been studied extensively, and no studies have focused Operating Engineers (heavy equipment operators) among whom daytime fatigue would place them at high risk for accidents. Therefore, the purpose of this study was to determine variables associated with sleep quality among Operating Engineers. This was a cross-sectional survey design with a dependent variable of sleep quality and independent variables of personal and related health behavioral factors. A convenience sample of 498 Operating Engineers was recruited from approximately 16,000 Operating Engineers from entire State of Michigan in 2008. Linear regression was used to determine personal and related health behavior factors associated with sleep quality. Multivariate analyses showed that personal factors related to poor sleep quality were younger age, female sex, higher pain, more medical comorbidities and depressive symptoms and behavioral factors related to poor sleep quality were nicotine dependence. While sleep scores were similar to population norms, approximately 34% (n=143) showed interest in health services for sleep problems. While many personal factors are not changeable, interventions to improve sleep hygiene as well as interventions to treat pain, depression and smoking may improve sleep quality resulting in less absenteeism, fatal work accidents, use of sick leave, work disability, medical comorbidities, as well as subsequent mortality. PMID:23393021

A Case Study in Organizational Change: Evaluation in Cooperative Extension

ERIC Educational Resources Information Center

Rennekamp, Roger A.; Engle, Molly

2008-01-01

This chapter examines how factors both internal and external to Cooperative Extension have influenced its commitment and capability to assess the quality and impact of its programs. The authors begin by documenting how the nature of Extension programming has changed dramatically in response to societal needs over the course of the organization's…

Power Extension Package (PEP) system definition extension, orbital service module systems analysis study. Volume 12: PEP data item descriptions

NASA Technical Reports Server (NTRS)

1979-01-01

Contractor information requirements necessary to support the power extension package project of the space shuttle program are specified for the following categories of data: project management; configuration management; systems engineering and test; manufacturing; reliability, quality assurance and safety; logistics; training; and operations.

SPATIAL PREDICTION OF AIR QUALITY DATA

EPA Science Inventory

Site-specific air quality monitoring data have been used extensively in both scientific and regulatory programs. As such, these data provide essential information to the public, environmental managers, and the atmospheric research community. Currently, air quality management prac...

A pilot cost-effectiveness analysis of treatments in newly diagnosed high-grade gliomas: the example of 5-aminolevulinic Acid compared with white-light surgery.

PubMed

Esteves, Susana; Alves, Marta; Castel-Branco, Marta; Stummer, Walter

2015-05-01

High-grade gliomas are aggressive, incurable tumors characterized by extensive diffuse invasion of the normal brain parenchyma. Novel therapies at best prolong survival; their costs are formidable and benefit is marginal. Economic restrictions thus require knowledge of the cost-effectiveness of treatments. Here, we show the cost-effectiveness of enhanced resections in malignant glioma surgery using a well-characterized tool for intraoperative tumor visualization, 5-aminolevulinic acid (5-ALA). To evaluate the cost-effectiveness of 5-ALA fluorescence-guided neurosurgery compared with white-light surgery in adult patients with newly diagnosed high-grade glioma, adopting the perspective of the Portuguese National Health Service. We used a Markov model (cohort simulation). Transition probabilities were estimated with the use of data from 1 randomized clinical trial and 1 noninterventional prospective study. Utility values and resource use were obtained from published literature and expert opinion. Unit costs were taken from official Portuguese reimbursement lists (2012 values). The health outcomes considered were quality-adjusted life-years, life-years, and progression-free life-years. Extensive 1-way and probabilistic sensitivity analyses were performed. The incremental cost-effectiveness ratios are below &OV0556;10 000 in all evaluated outcomes, being around &OV0556;9100 per quality-adjusted life-year gained, &OV0556;6700 per life-year gained, and &OV0556;8800 per progression-free life-year gained. The probability of 5-ALA fluorescence-guided surgery cost-effectiveness at a threshold of &OV0556;20000 is 96.0% for quality-adjusted life-year, 99.6% for life-year, and 98.8% for progression-free life-year. 5-ALA fluorescence-guided surgery appears to be cost-effective in newly diagnosed high-grade gliomas compared with white-light surgery. This example demonstrates cost-effectiveness analyses for malignant glioma surgery to be feasible on the basis of existing data.

Role of Process Control in Improving Space Vehicle Safety A Space Shuttle External Tank Example

NASA Technical Reports Server (NTRS)

Safie, Fayssal M.; Nguyen, Son C.; Burleson, Keith W.

2006-01-01

Developing a safe and reliable space vehicle requires good design and good manufacturing, or in other words "design it right and build it right". A great design can be hard to build or manufacture mainly due to difficulties related to quality. Specifically, process control can be a challenge. As a result, the system suffers from low quality which leads to low reliability and high system risk. The Space Shuttle has experienced some of those cases, but has overcome these difficulties through extensive redesign efforts and process enhancements. One example is the design of the hot gas temperature sensor on the Space Shuttle Main Engine (SSME), which resulted in failure of the sensor in flight and led to a redesign of the sensor. The most recent example is the Space Shuttle External Tank (ET) Thermal Protection System (TPS) reliability issues that contributed to the Columbia accident. As a result, extensive redesign and process enhancement activities have been performed over the last two years to minimize the sensitivities and difficulties of the manual TPS application process.

76 FR 13289 - Approval of One-Year Extension for Attaining the 1997 8-Hour Ozone Standard in the Baltimore...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-11

...). This extension is based on the air quality data for the 4th highest daily 8-hour monitored value during... first one-year extension, the area's 4th highest daily 8-hour average in the attainment year is 0.084 parts per million (ppm) or less. (b) For the second one-year extension, the area's 4th highest daily 8...

Development of a carbonate platform with potential for large discoveries - an example from Vietnam

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mayall, M.; Bent, A.; Dale, B.

1996-01-01

In offshore central and southern Vietnam a number of carbonate accumulations can be recognized. Platform carbonates form basin-wide units of carbonate characterized by strong, continuous parallel seismic reflectors. Facies are dominated by bioclastic wackestones with poor-moderate reservoir quality. On the more isolated highs, large buildups developed. These are typically 5-10 km across and 300 m thick. They unconformably overlie the platform carbonate facies which are extensively karstified. In places these are pinnacles, typically 2-5 km across, 300 m+ thick with chaotic or mounded internal seismic facies. The large carbonate buildups are characterized by steep sided slopes with talus cones, reef-marginmore » rims usually developed around only part of the buildup, and a prominent back-stepping geometry. Buildup interior facies form the main potential reservoirs They are dominated by fine to coarse grained coralgal packstones. Fine grained carbonates are associated with deeper water events and multiple karst surfaces can also be identified. Reservoir quality is excellent, largely controlled by extensive dissolution and dolomitization believed to be related to the exposure events. Gas has been found in a number of reservoirs. Heterogeneities can be recognized which could potentially effect production. These include the extensive finer grained facies, cementation or open fissures associated with the karst surfaces, a more cemented reef rim, shallowing upwards facies cycles and faults.« less

Development of a carbonate platform with potential for large discoveries - an example from Vietnam

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mayall, M.; Bent, A.; Dale, B.

1996-12-31

In offshore central and southern Vietnam a number of carbonate accumulations can be recognized. Platform carbonates form basin-wide units of carbonate characterized by strong, continuous parallel seismic reflectors. Facies are dominated by bioclastic wackestones with poor-moderate reservoir quality. On the more isolated highs, large buildups developed. These are typically 5-10 km across and 300 m thick. They unconformably overlie the platform carbonate facies which are extensively karstified. In places these are pinnacles, typically 2-5 km across, 300 m+ thick with chaotic or mounded internal seismic facies. The large carbonate buildups are characterized by steep sided slopes with talus cones, reef-marginmore » rims usually developed around only part of the buildup, and a prominent back-stepping geometry. Buildup interior facies form the main potential reservoirs They are dominated by fine to coarse grained coralgal packstones. Fine grained carbonates are associated with deeper water events and multiple karst surfaces can also be identified. Reservoir quality is excellent, largely controlled by extensive dissolution and dolomitization believed to be related to the exposure events. Gas has been found in a number of reservoirs. Heterogeneities can be recognized which could potentially effect production. These include the extensive finer grained facies, cementation or open fissures associated with the karst surfaces, a more cemented reef rim, shallowing upwards facies cycles and faults.« less

Computation of Transonic Nozzle Sound Transmission and Rotor Problems by the Dispersion-Relation-Preserving Scheme

NASA Technical Reports Server (NTRS)

Tam, Christopher K. W.; Aganin, Alexei

2000-01-01

The transonic nozzle transmission problem and the open rotor noise radiation problem are solved computationally. Both are multiple length scales problems. For efficient and accurate numerical simulation, the multiple-size-mesh multiple-time-step Dispersion-Relation-Preserving scheme is used to calculate the time periodic solution. To ensure an accurate solution, high quality numerical boundary conditions are also needed. For the nozzle problem, a set of nonhomogeneous, outflow boundary conditions are required. The nonhomogeneous boundary conditions not only generate the incoming sound waves but also, at the same time, allow the reflected acoustic waves and entropy waves, if present, to exit the computation domain without reflection. For the open rotor problem, there is an apparent singularity at the axis of rotation. An analytic extension approach is developed to provide a high quality axis boundary treatment.

VizieR Online Data Catalog: Hi-GAL. inner Milky Way: +68>=l>=70 (Molinari+, 2016)

NASA Astrophysics Data System (ADS)

Molinari, S.; Schisano, E.; Elia, D.; Pestalozzi, M.; Traficante, A.; Pezzuto, S.; Swinyard, B. M.; Noriega-Crespo, A.; Bally, J.; Moore, T. J. T.; Plume, R.; Zavagno, A.; di Giorgio A. M.; Liu, S. J.; Pilbratt, G. L.; Mottram, J. C.; Russeil, D.; Piazzo, L.; Veneziani, M.; Benedettini, M.; Calzoletti, L.; Faustini, F.; Natoli, P.; Piacentini, F.; Merello, M.; Palmese, A.; Del Grande, R.; Polychroni, D.; Rygl, K. L. J.; Polenta, G.; Barlow, M. J.; Bernard, J.-P.; Martin, P. G.; Testi, L.; Ali, B.; Andre, P.; Beltran, M. T.; Billot, N.; Carey, S.; Cesaroni, R.; Compiegne, M.; Eden, D.; Fukui, Y.; Garcia-Lario, P.; Hoare, M. G.; Huang, M.; Joncas, G.; Lim, T. L.; Lord, S. D.; Martinavarro-Armengol, S.; Motte, F.; Paladini, R.; Paradis, D.; Peretto, N.; Robitaille, T.; Schilke, P.; Schneider, N.; Schulz, B.; Sibthorpe, B.; Strafella, F.; Thompson, M. A.; Umana, G.; Ward-Thompson, D.; Wyrowski, F.

2016-08-01

This is the first public data release of high-quality products from the Herschel Hi-GAL survey. The release comes two years after the end of the Herschel observing campaign and is the result of extensive testing of the data reduction and extraction procedures created by members of the Hi-GAL consortium. The complexity and the large variation of the background conditions in all Herschel wavelength bands makes source extraction on the Galactic plane a challenging task. With Hi-GAL DR1, we provide access (http://vialactea.iaps.inaf.it) through a cutout service to high-quality images and compact source catalogues for the Galactic plane at 70, 160, 250, 350, and 500um in the region 68°>=l>=-70° and |b|<= 1°. (6 data files).

Ultra precision machining

NASA Astrophysics Data System (ADS)

Debra, Daniel B.; Hesselink, Lambertus; Binford, Thomas

1990-05-01

There are a number of fields that require or can use to advantage very high precision in machining. For example, further development of high energy lasers and x ray astronomy depend critically on the manufacture of light weight reflecting metal optical components. To fabricate these optical components with machine tools they will be made of metal with mirror quality surface finish. By mirror quality surface finish, it is meant that the dimensions tolerances on the order of 0.02 microns and surface roughness of 0.07. These accuracy targets fall in the category of ultra precision machining. They cannot be achieved by a simple extension of conventional machining processes and techniques. They require single crystal diamond tools, special attention to vibration isolation, special isolation of machine metrology, and on line correction of imperfection in the motion of the machine carriages on their way.

A Model of Human Variability in Viable Ship Design

DTIC Science & Technology

2014-02-21

when an organization is in a state of change. For example, an alternative to screening out individuals for a new job role is the self -selection of...being done and group members little care what happens beyond their self -imposed borders. The proposed extension addresses team decay with regard to the...these, the paygrade of team members probably reflects qualities of most interest from the authors’ point of 22 view. Paygrade is highly

Assessment of the quality of harms reporting in non-randomised studies and randomised controlled studies of topiramate for the treatment of epilepsy using CONSORT criteria.

PubMed

Carmichael, Katie; Nolan, Sarah J; Weston, Jennifer; Tudur Smith, Catrin; Marson, Anthony G

2015-08-01

Treatment decisions should be informed by high quality evidence of both the potential benefit and harms of treatment alternatives. Randomised controlled trials (RCTs) provide the best evidence regarding benefits; however information relating to serious, rare and long-term harms is usually available only from non-randomised studies (NRSs). The aim of this study was to use a checklist based on the CONSORT (Consolidating Standards for Reporting Trials) extension for harms recommendations to assess the quality of reporting of harms data in both NRSs and RCTs of antiepileptic drugs, using studies of topiramate as an example. Seventy-eight studies were included from an online search of seven databases. Harms data was extracted from each study using a 25-point checklist. The mean number of items met was 11.5 (SD 2.96) per study. Commercially funded studies met on average 12.7 items and non-commercially funded studies met 10.08 (p value < 0.001). RCTs met on average 13.0 items and NRSs met 10.8 (p = 0.001). Multi-centre studies and commercially funded studies met significantly more items than single centre and non-commercially funded studies respectively. There was no significant difference in the mean number of items met by studies that had included adult vs. child participants, or studies published pre- vs. post-CONSORT extension for harms in 2004. Reporting of harms is significantly better in RCTs than in NRSs of TPM, but is suboptimal overall and has not improved since the publication of CONSORT extension for harms in 2004. There is a need to improve the reporting of harms in order to better inform treatment decisions. Copyright © 2015 Elsevier B.V. All rights reserved.

[The biobank of the German National Cohort as a resource for epidemiologic research].

PubMed

Wichmann, H-Erich; Hörlein, Andreas; Ahrens, Wolfgang; Nauck, Matthias

2016-03-01

The linkage of high-quality biosamples with detailed data from medical examinations, questionnaires and interviews offers great opportunities for research. This is particularly true for large-scale prospective epidemiological studies with long observation periods, like the German National Cohort (GNC). The modalities of collecting, processing and storing biosamples of high quality and with a high throughput, as well as ethical aspects are described using the GNC as an example. For the GNC, 200,000 randomly selected adults will be recruited by 18 study centres and will be followed up for 20-30 years. In addition to the extensive basic examination protocol, followed by reassessment examinations and follow-up questionnaires, the biorepository is a cornerstone of the GNC. The GNC biorepository will comprise more than 20 million aliquots of plasma, serum, erythrocytes, lymphocytes, urine, saliva, nasal swabs and stool. Preanalytics and aliquoting are performed locally in the study centres and are highly standardised and extensively automated. All samples are stored at - 80 and - 180 °C, respectively. A laboratory information system documents all processing steps and storage locations. Access to data and biosamples will be granted to researchers within and outside Germany after completion of the baseline recruitment (i.e. from 2018 onwards). Experience with already existing epidemiological biobanks shows impressive results, especially with regard to genetic research, as well as post-genomics (e.g. transcriptomics, metabolomics, epigenomics). Previous success stories explain the strongly increased demand for data and biosamples from the population. Thus the GNC will provide an important resource for biomedical research in the future.

Clinical indications for high-field 1.5 T intraoperative magnetic resonance imaging and neuro-navigation for neurosurgical procedures. Review of initial 100 cases.

PubMed

Maesawa, Satoshi; Fujii, Masazumi; Nakahara, Norimoto; Watanabe, Tadashi; Saito, Kiyoshi; Kajita, Yasukazu; Nagatani, Tetsuya; Wakabayashi, Toshihiko; Yoshida, Jun

2009-08-01

Initial experiences are reviewed in an integrated operation theater equipped with an intraoperative high-field (1.5 T) magnetic resonance (MR) imager and neuro-navigation (BrainSUITE), to evaluate the indications and limitations. One hundred consecutive cases were treated, consisting of 38 gliomas, 49 other tumors, 11 cerebrovascular diseases, and 2 functional diseases. The feasibility and usefulness of the integrated theater were evaluated for individual diseases, focusing on whether intraoperative images (including diffusion tensor imaging) affected the surgical strategy. The extent of resection and outcomes in each histological category of brain tumors were examined. Intraoperative high-field MR imaging frequently affected or modified the surgical strategy in the glioma group (27/38 cases, 71.1%), but less in the other tumor group (13/49 cases, 26.5%). The surgical strategy was not modified in cerebrovascular or functional diseases, but the success of procedures and the absence of complications could be confirmed. In glioma surgery, subtotal or greater resection was achieved in 22 of the 31 patients (71%) excluding biopsies, and intraoperative images revealed tumor remnants resulting in the extension of resection in 21 of the 22 patients (95.4%), the highest rate of extension among all types of pathologies. The integrated neuro-navigation improved workflow. The best indication for intraoperative high-field MR imaging and integrated neuro-navigation is brain tumors, especially gliomas, and is supplementary in assuring quality in surgery for cerebrovascular or functional diseases. Immediate quality assurance is provided in several types of neurosurgical procedures.

Information needs related to extension service and community outreach.

PubMed

Bottcher, Robert W

2003-06-01

Air quality affects everyone. Some people are affected by air quality impacts, regulations, and technological developments in several ways. Stakeholders include the medical community, ecologists, government regulators, industries, technology providers, academic professionals, concerned citizens, the news media, and elected officials. Each of these groups may perceive problems and opportunities differently, but all need access to information as it is developed. The diversity and complexity of air quality problems contribute to the challenges faced by extension and outreach professionals who must communicate with stakeholders having diverse backgrounds. Gases, particulates, biological aerosols, pathogens, and odors all require expensive and relatively complex technology to measure and control. Economic constraints affect the ability of regulators and others to measure air quality, and industry and others to control it. To address these challenges, while communicating air quality research results and concepts to stakeholders, three areas of information needs are evident. (1) A basic understanding of the fundamental concepts regarding air pollutants and their measurement and control is needed by all stakeholders; the Extension Specialist, to be effective, must help people move some distance up the learning curve. (2) Each problem or set of problems must be reasonably well defined since comprehensive solution of all problems simultaneously may not be feasible; for instance, the solution of an odor problem associated with animal production may not address atmospheric effects due to ammonia emissions. (3) The integrity of the communication process must be preserved by avoiding prejudice and protectionism; although stakeholders may seek to modify information to enhance their interests, extension and outreach professionals must be willing to present unwelcome information or admit to a lack of information. A solid grounding in fundamental concepts, careful and fair problem definition, and a resolute commitment to integrity and credibility will enable effective communication of air quality information to and among diverse stakeholders.

A Flexible Annular-Array Imaging Platform for Micro-Ultrasound

PubMed Central

Qiu, Weibao; Yu, Yanyan; Chabok, Hamid Reza; Liu, Cheng; Tsang, Fu Keung; Zhou, Qifa; Shung, K. Kirk; Zheng, Hairong; Sun, Lei

2013-01-01

Micro-ultrasound is an invaluable imaging tool for many clinical and preclinical applications requiring high resolution (approximately several tens of micrometers). Imaging systems for micro-ultrasound, including single-element imaging systems and linear-array imaging systems, have been developed extensively in recent years. Single-element systems are cheaper, but linear-array systems give much better image quality at a higher expense. Annular-array-based systems provide a third alternative, striking a balance between image quality and expense. This paper presents the development of a novel programmable and real-time annular-array imaging platform for micro-ultrasound. It supports multi-channel dynamic beamforming techniques for large-depth-of-field imaging. The major image processing algorithms were achieved by a novel field-programmable gate array technology for high speed and flexibility. Real-time imaging was achieved by fast processing algorithms and high-speed data transfer interface. The platform utilizes a printed circuit board scheme incorporating state-of-the-art electronics for compactness and cost effectiveness. Extensive tests including hardware, algorithms, wire phantom, and tissue mimicking phantom measurements were conducted to demonstrate good performance of the platform. The calculated contrast-to-noise ratio (CNR) of the tissue phantom measurements were higher than 1.2 in the range of 3.8 to 8.7 mm imaging depth. The platform supported more than 25 images per second for real-time image acquisition. The depth-of-field had about 2.5-fold improvement compared to single-element transducer imaging. PMID:23287923

Cancer-Specific Stress and Mood Disturbance: Implications for Symptom Perception, Quality of Life, and Immune Response in Women Shortly after Diagnosis of Breast Cancer

PubMed Central

Kang, Duck-Hee; Park, Na-Jin; McArdle, Traci

2012-01-01

Purpose. To determine the levels of cancer-specific stress and mood disturbance in women shortly after diagnosis of breast cancer and to assess their associations with symptom perception, quality of life, and immune response. Design. Descriptive and correlational. Sample and Setting. One hundred women with newly diagnosed breast cancer were recruited from interdisciplinary breast clinics. Methods. Baseline data were collected using standardized questionnaires and established bioassay prior to the initiation of cancer adjuvant therapy. Blood samples were collected about the same time of day. Results. High cancer-specific stress was significantly correlated with high mood disturbance, which, in turn, was correlated with high symptom perception, poor quality of life, and an immune profile indicating high neutrophils and low lymphocytes. Conclusions. High cancer-specific stress and related mood disturbance show extensive negative relationships with multiple behavioral, clinical, and biological factors. Implications for Nursing. Routine screening for cancer-related stress and mood disturbance should be incorporated into nursing practice for all patients diagnosed with cancer. Given broad negative associations with other biobehavioral factors, early identification of patients at risk and provision and evaluation of stress and mood management programs may have a beneficial effect on subsequent health outcomes over time. PMID:23316388

78 FR 70905 - Extension of Comment Period for the Water Quality Standards Regulatory Clarifications Proposed Rule

Federal Register 2010, 2011, 2012, 2013, 2014

2013-11-27

... Comment Period for the Water Quality Standards Regulatory Clarifications Proposed Rule AGENCY... Environmental Protection Agency (EPA) is extending the comment period for the proposed rule ``Water Quality... published the proposed rule ``Water Quality Standards Regulatory Clarifications'' in the Federal Register...

Putting Extension on a Spot

ERIC Educational Resources Information Center

Lawrence, James E.

1970-01-01

Between and during television programs from WNBF-TV, Binghamton, New York, the Extension Service is providing public service announcements giving information on nutrition, food stamps, forage pests, outdoor recreation, farm safety, environmental quality, and many other subjects. (EB)

Promoting Pluralism.

ERIC Educational Resources Information Center

Zijp, W.

1998-01-01

Rural agricultural development is facing challenges of poverty, hunger, and environmental quality, necessitating sustainable, profitable, and productive practices. Extension education is challenged to increase diversity, relevance, and financial support. Examples of World Bank innovations illustrate some pathways for agricultural extension. (SK)

Reporting characteristics of meta-analyses in orthodontics: methodological assessment and statistical recommendations.

PubMed

Papageorgiou, Spyridon N; Papadopoulos, Moschos A; Athanasiou, Athanasios E

2014-02-01

Ideally meta-analyses (MAs) should consolidate the characteristics of orthodontic research in order to produce an evidence-based answer. However severe flaws are frequently observed in most of them. The aim of this study was to evaluate the statistical methods, the methodology, and the quality characteristics of orthodontic MAs and to assess their reporting quality during the last years. Electronic databases were searched for MAs (with or without a proper systematic review) in the field of orthodontics, indexed up to 2011. The AMSTAR tool was used for quality assessment of the included articles. Data were analyzed with Student's t-test, one-way ANOVA, and generalized linear modelling. Risk ratios with 95% confidence intervals were calculated to represent changes during the years in reporting of key items associated with quality. A total of 80 MAs with 1086 primary studies were included in this evaluation. Using the AMSTAR tool, 25 (27.3%) of the MAs were found to be of low quality, 37 (46.3%) of medium quality, and 18 (22.5%) of high quality. Specific characteristics like explicit protocol definition, extensive searches, and quality assessment of included trials were associated with a higher AMSTAR score. Model selection and dealing with heterogeneity or publication bias were often problematic in the identified reviews. The number of published orthodontic MAs is constantly increasing, while their overall quality is considered to range from low to medium. Although the number of MAs of medium and high level seems lately to rise, several other aspects need improvement to increase their overall quality.

A peptide extension dictates IgM assembly

PubMed Central

Pasalic, Dzana; Weber, Benedikt; Giannone, Chiara; Anelli, Tiziana; Müller, Roger; Fagioli, Claudio; Felkl, Manuel; John, Christine; Mossuto, Maria Francesca; Sitia, Roberto; Buchner, Johannes

2017-01-01

Professional secretory cells can produce large amounts of high-quality complex molecules, including IgM antibodies. Owing to their multivalency, polymeric IgM antibodies provide an efficient first-line of defense against pathogens. To decipher the mechanisms of IgM assembly, we investigated its biosynthesis in living cells and faithfully reconstituted the underlying processes in vitro. We find that a conserved peptide extension at the C-terminal end of the IgM heavy (Ig-μ) chains, termed the tailpiece, is necessary and sufficient to establish the correct geometry. Alanine scanning revealed that hydrophobic amino acids in the first half of the tailpiece contain essential information for generating the correct topology. Assembly is triggered by the formation of a disulfide bond linking two tailpieces. This induces conformational changes in the tailpiece and the adjacent domain, which drive further polymerization. Thus, the biogenesis of large and topologically challenging IgM complexes is dictated by a local conformational switch in a peptide extension. PMID:28973899

Too Little, Too Late: Ineffective Regulation of Dietary Supplements in the United States

PubMed Central

2015-01-01

Millions of people in the United States consume dietary supplements hoping to maintain or improve their health; however, extensive research has failed to demonstrate the efficacy of numerous supplements in disease prevention. In addition, concerns about the safety of routine and high-dose supplementation have been raised. The Food and Drug Administration regulates dietary supplement quality, safety, and labeling, and the Federal Trade Commission monitors advertisements and marketing; still, vast enforcement challenges remain, and optimal governmental oversight has not been achieved. If the composition and quality of ingredients cannot be reliably ensured, the validity of research on dietary supplements is questionable. Moreover, the health of the US public is put at risk. PMID:25602879

Application of quality by design for 3D printed bone prostheses and scaffolds

PubMed Central

Martinez-Marquez, Daniel; Mirnajafizadeh, Ali; Carty, Christopher P.

2018-01-01

3D printing is an emergent manufacturing technology recently being applied in the medical field for the development of custom bone prostheses and scaffolds. However, successful industry transformation to this new design and manufacturing approach requires technology integration, concurrent multi-disciplinary collaboration, and a robust quality management framework. This latter change enabler is the focus of this study. While a number of comprehensive quality frameworks have been developed in recent decades to ensure that the manufacturing of medical devices produces reliable products, they are centred on the traditional context of standardised manufacturing techniques. The advent of 3D printing technologies and the prospects for mass customisation provides significant market opportunities, but also presents a serious challenge to regulatory bodies tasked with managing and assuring product quality and safety. Before 3D printing bone prostheses and scaffolds can gain traction, industry stakeholders, such as regulators, clients, medical practitioners, insurers, lawyers, and manufacturers, would all require a high degree of confidence that customised manufacturing can achieve the same quality outcomes as standardised manufacturing. A Quality by Design (QbD) approach to custom 3D printed prostheses can help to ensure that products are designed and manufactured correctly from the beginning without errors. This paper reports on the adaptation of the QbD approach for the development process of 3D printed custom bone prosthesis and scaffolds. This was achieved through the identification of the Critical Quality Attributes of such products, and an extensive review of different design and fabrication methods for 3D printed bone prostheses. Research outcomes include the development of a comprehensive design and fabrication process flow diagram, and categorised risks associated with the design and fabrication processes of such products. An extensive systematic literature review and post-hoc evaluation survey with experts was completed to evaluate the likely effectiveness of the herein suggested QbD framework. PMID:29649231

Implementing a Data Quality Strategy to Simplify Access to Data

NASA Astrophysics Data System (ADS)

Druken, K. A.; Trenham, C. E.; Evans, B. J. K.; Richards, C. J.; Wang, J.; Wyborn, L. A.

2016-12-01

To ensure seamless programmatic access for data analysis (including machine learning), standardization of both data and services is vital. At the Australian National Computational Infrastructure (NCI) we have developed a Data Quality Strategy (DQS) that currently provides processes for: (1) the consistency of data structures in the underlying High Performance Data (HPD) platform; (2) quality control through compliance with recognized community standards; and (3) data quality assurance through demonstrated functionality across common platforms, tools and services. NCI hosts one of Australia's largest repositories (10+ PBytes) of research data collections spanning datasets from climate, coasts, oceans and geophysics through to astronomy, bioinformatics and the social sciences. A key challenge is the application of community-agreed data standards to the broad set of Earth systems and environmental data that are being used. Within these disciplines, data span a wide range of gridded, ungridded (i.e., line surveys, point clouds), and raster image types, as well as diverse coordinate reference projections and resolutions. By implementing our DQS we have seen progressive improvement in the quality of the datasets across the different subject domains, and through this, the ease by which the users can programmatically access the data, either in situ or via web services. As part of its quality control procedures, NCI has developed a compliance checker based upon existing domain standards. The DQS also includes extensive Functionality Testing which include readability by commonly used libraries (e.g., netCDF, HDF, GDAL, etc.); accessibility by data servers (e.g., THREDDS, Hyrax, GeoServer), validation against scientific analysis and programming platforms (e.g., Python, Matlab, QGIS); and visualization tools (e.g., ParaView, NASA Web World Wind). These tests ensure smooth interoperability between products and services as well as exposing unforeseen requirements and dependencies. The results provide an important component of quality control within the DQS as well as clarifying the requirement for any extensions to the relevant standards that help support the uptake of data by broader international communities.

Application of quality by design for 3D printed bone prostheses and scaffolds.

PubMed

Martinez-Marquez, Daniel; Mirnajafizadeh, Ali; Carty, Christopher P; Stewart, Rodney A

2018-01-01

3D printing is an emergent manufacturing technology recently being applied in the medical field for the development of custom bone prostheses and scaffolds. However, successful industry transformation to this new design and manufacturing approach requires technology integration, concurrent multi-disciplinary collaboration, and a robust quality management framework. This latter change enabler is the focus of this study. While a number of comprehensive quality frameworks have been developed in recent decades to ensure that the manufacturing of medical devices produces reliable products, they are centred on the traditional context of standardised manufacturing techniques. The advent of 3D printing technologies and the prospects for mass customisation provides significant market opportunities, but also presents a serious challenge to regulatory bodies tasked with managing and assuring product quality and safety. Before 3D printing bone prostheses and scaffolds can gain traction, industry stakeholders, such as regulators, clients, medical practitioners, insurers, lawyers, and manufacturers, would all require a high degree of confidence that customised manufacturing can achieve the same quality outcomes as standardised manufacturing. A Quality by Design (QbD) approach to custom 3D printed prostheses can help to ensure that products are designed and manufactured correctly from the beginning without errors. This paper reports on the adaptation of the QbD approach for the development process of 3D printed custom bone prosthesis and scaffolds. This was achieved through the identification of the Critical Quality Attributes of such products, and an extensive review of different design and fabrication methods for 3D printed bone prostheses. Research outcomes include the development of a comprehensive design and fabrication process flow diagram, and categorised risks associated with the design and fabrication processes of such products. An extensive systematic literature review and post-hoc evaluation survey with experts was completed to evaluate the likely effectiveness of the herein suggested QbD framework.

Wide-Bandwidth, Wide-Beamwidth, High-Resolution, Millimeter-Wave Imaging for Concealed Weapon Detection

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sheen, David M.; Fernandes, Justin L.; Tedeschi, Jonathan R.

2013-06-12

Active millimeter-wave imaging is currently being used for personnel screening at airports and other high-security facilities. The lateral resolution, depth resolution, clothing penetration, and image illumination quality obtained from next-generation systems can be significantly enhanced through the selection the aperture size, antenna beamwidth, center frequency, and bandwidth. In this paper, the results of an extensive imaging trade study are presented using both planar and cylindrical three-dimensional imaging techniques at frequency ranges of 10-20 GHz, 10 – 40 GHz, 40 – 60 GHz, and 75 – 105 GHz

Clinical Decision Support System to Enhance Quality Control of Spirometry Using Information and Communication Technologies

PubMed Central

2014-01-01

Background We recently demonstrated that quality of spirometry in primary care could markedly improve with remote offline support from specialized professionals. It is hypothesized that implementation of automatic online assessment of quality of spirometry using information and communication technologies may significantly enhance the potential for extensive deployment of a high quality spirometry program in integrated care settings. Objective The objective of the study was to elaborate and validate a Clinical Decision Support System (CDSS) for automatic online quality assessment of spirometry. Methods The CDSS was done through a three step process including: (1) identification of optimal sampling frequency; (2) iterations to build-up an initial version using the 24 standard spirometry curves recommended by the American Thoracic Society; and (3) iterations to refine the CDSS using 270 curves from 90 patients. In each of these steps the results were checked against one expert. Finally, 778 spirometry curves from 291 patients were analyzed for validation purposes. Results The CDSS generated appropriate online classification and certification in 685/778 (88.1%) of spirometry testing, with 96% sensitivity and 95% specificity. Conclusions Consequently, only 93/778 (11.9%) of spirometry testing required offline remote classification by an expert, indicating a potential positive role of the CDSS in the deployment of a high quality spirometry program in an integrated care setting. PMID:25600957

Phenology and Cover of Plant Growth Forms Predict Herbivore Habitat Selection in a High Latitude Ecosystem

PubMed Central

Fauchald, Per; Langeland, Knut; Ims, Rolf A.; Yoccoz, Nigel G.; Bråthen, Kari Anne

2014-01-01

The spatial and temporal distribution of forage quality is among the most central factors affecting herbivore habitat selection. Yet, for high latitude areas, forage quantity has been found to be more important than quality. Studies on large ungulate foraging patterns are faced with methodological challenges in both assessing animal movements at the scale of forage distribution, and in assessing forage quality with relevant metrics. Here we use first-passage time analyses to assess how reindeer movements relate to forage quality and quantity measured as the phenology and cover of growth forms along reindeer tracks. The study was conducted in a high latitude ecosystem dominated by low-palatable growth forms. We found that the scale of reindeer movement was season dependent, with more extensive area use as the summer season advanced. Small-scale movement in the early season was related to selection for younger stages of phenology and for higher abundances of generally phenologically advanced palatable growth forms (grasses and deciduous shrubs). Also there was a clear selection for later phenological stages of the most dominant, yet generally phenologically slow and low-palatable growth form (evergreen shrubs). As the summer season advanced only quantity was important, with selection for higher quantities of one palatable growth form and avoidance of a low palatable growth form. We conclude that both forage quality and quantity are significant predictors to habitat selection by a large herbivore at high latitude. The early season selectivity reflected that among dominating low palatability growth forms there were palatable phenological stages and palatable growth forms available, causing herbivores to be selective in their habitat use. The diminishing selectivity and the increasing scale of movement as the season developed suggest a response by reindeer to homogenized forage availability of low quality. PMID:24972188

Phenology and cover of plant growth forms predict herbivore habitat selection in a high latitude ecosystem.

PubMed

Iversen, Marianne; Fauchald, Per; Langeland, Knut; Ims, Rolf A; Yoccoz, Nigel G; Bråthen, Kari Anne

2014-01-01

The spatial and temporal distribution of forage quality is among the most central factors affecting herbivore habitat selection. Yet, for high latitude areas, forage quantity has been found to be more important than quality. Studies on large ungulate foraging patterns are faced with methodological challenges in both assessing animal movements at the scale of forage distribution, and in assessing forage quality with relevant metrics. Here we use first-passage time analyses to assess how reindeer movements relate to forage quality and quantity measured as the phenology and cover of growth forms along reindeer tracks. The study was conducted in a high latitude ecosystem dominated by low-palatable growth forms. We found that the scale of reindeer movement was season dependent, with more extensive area use as the summer season advanced. Small-scale movement in the early season was related to selection for younger stages of phenology and for higher abundances of generally phenologically advanced palatable growth forms (grasses and deciduous shrubs). Also there was a clear selection for later phenological stages of the most dominant, yet generally phenologically slow and low-palatable growth form (evergreen shrubs). As the summer season advanced only quantity was important, with selection for higher quantities of one palatable growth form and avoidance of a low palatable growth form. We conclude that both forage quality and quantity are significant predictors to habitat selection by a large herbivore at high latitude. The early season selectivity reflected that among dominating low palatability growth forms there were palatable phenological stages and palatable growth forms available, causing herbivores to be selective in their habitat use. The diminishing selectivity and the increasing scale of movement as the season developed suggest a response by reindeer to homogenized forage availability of low quality.

Physical habitat and water quality correlates of crayfish distributions in a mined watershed

USGS Publications Warehouse

Welsh, Stuart A.; Loughman, Zachary J.

2014-01-01

In mined watersheds, water quality alters aquatic faunas, but few studies have focused on associations between stream habitat and crayfish distributions. We examined associations of water quality and physical habitat quality on presence/absence of six crayfish species in the upper Kanawha River drainage of southern West Virginia, USA, a region with a long history of surface and mountaintop removal mining of coal. Data supported an association of physical habitat quality with the presence of four species (Cambarus carinirostris, Cambarus robustus, Cambarus cf. sciotensis, and Orconectes sanbornii). Cambarus bartonii cavatus and the non-native Orconectes virilis were associated with lower quality physical habitat than that of the other four species. Relative to other species, C. b. cavatus was associated with the lowest conductivity values, whereas O. virilis was associated with the highest conductivity values. Secondary and tertiary burrowers were generally associated with relatively high-quality physical habitat. However, C. b. cavatus, a crayfish known to burrow extensively in headwater streams, was associated with the lowest quality physical habitat. Physical habitat quality was generally supported over stream conductivity as a variable influencing crayfish distributions. Our data demonstrate the importance of stream habitat quality when assessing crayfish assemblages within mined watersheds.

Active Semi-Supervised Community Detection Based on Must-Link and Cannot-Link Constraints

PubMed Central

Cheng, Jianjun; Leng, Mingwei; Li, Longjie; Zhou, Hanhai; Chen, Xiaoyun

2014-01-01

Community structure detection is of great importance because it can help in discovering the relationship between the function and the topology structure of a network. Many community detection algorithms have been proposed, but how to incorporate the prior knowledge in the detection process remains a challenging problem. In this paper, we propose a semi-supervised community detection algorithm, which makes full utilization of the must-link and cannot-link constraints to guide the process of community detection and thereby extracts high-quality community structures from networks. To acquire the high-quality must-link and cannot-link constraints, we also propose a semi-supervised component generation algorithm based on active learning, which actively selects nodes with maximum utility for the proposed semi-supervised community detection algorithm step by step, and then generates the must-link and cannot-link constraints by accessing a noiseless oracle. Extensive experiments were carried out, and the experimental results show that the introduction of active learning into the problem of community detection makes a success. Our proposed method can extract high-quality community structures from networks, and significantly outperforms other comparison methods. PMID:25329660

Wing Shaping and Gust Load Controls of Flexible Aircraft: An LPV Approach

NASA Technical Reports Server (NTRS)

Hammerton, Jared R.; Su, Weihua; Zhu, Guoming; Swei, Sean Shan-Min

2018-01-01

In the proposed paper, the optimum wing shape of a highly flexible aircraft under varying flight conditions will be controlled by a linear parameter-varying approach. The optimum shape determined under multiple objectives, including flight performance, ride quality, and control effort, will be determined as well. This work is an extension of work done previously by the authors, and updates the existing optimization and utilizes the results to generate a robust flight controller.

Embedded wavelet packet transform technique for texture compression

NASA Astrophysics Data System (ADS)

Li, Jin; Cheng, Po-Yuen; Kuo, C.-C. Jay

1995-09-01

A highly efficient texture compression scheme is proposed in this research. With this scheme, energy compaction of texture images is first achieved by the wavelet packet transform, and an embedding approach is then adopted for the coding of the wavelet packet transform coefficients. By comparing the proposed algorithm with the JPEG standard, FBI wavelet/scalar quantization standard and the EZW scheme with extensive experimental results, we observe a significant improvement in the rate-distortion performance and visual quality.

Towards a Culture of Quality. Perspectives on Distance Education

ERIC Educational Resources Information Center

Koul, Badri N., Ed.; Kanwar, Asha, Ed.

2006-01-01

This third publication on the theme of quality in the Commonwealth of Learning Perspectives on Distance Education series widens the discussion beyond external quality assurance processes to a more generic focus on a "culture of quality." It is an extension of the earlier two publications, which came out in 1994 and 1997 and drew…

Individualised second line anti-tuberculous therapy for an extensively resistant pulmonary tuberculosis (XDR PTB) in East Malaysia.

PubMed

Muhammad Redzwan, S R A; Ralph, A P; Sivaraman Kannan, K K; William, T

2015-06-01

Clinical experience with extensively Drug Resistant tuberculosis (XDR-TB) has not been reported in Malaysia before. We describe the clinical characteristics, risk factors, progress and therapeutic regimen for a healthcare worker with XDR-TB, who had failed therapy for multidrug resistant TB (MDR TB) in our institution. This case illustrates the risk of TB among healthcare workers in high TB-burden settings, the importance of obtaining upfront culture and susceptibility results in all new TB cases, the problem of acquired drug resistance developing during MDR-TB treatment, the challenges associated with XDR-TB treatment regimens, the value of surgical resection in refractory cases, and the major quality of life impact this disease can have on young, economically productive individuals.

GeoViQua: quality-aware geospatial data discovery and evaluation

NASA Astrophysics Data System (ADS)

Bigagli, L.; Papeschi, F.; Mazzetti, P.; Nativi, S.

2012-04-01

GeoViQua (QUAlity aware VIsualization for the Global Earth Observation System of Systems) is a recently started FP7 project aiming at complementing the Global Earth Observation System of Systems (GEOSS) with rigorous data quality specifications and quality-aware capabilities, in order to improve reliability in scientific studies and policy decision-making. GeoViQua main scientific and technical objective is to enhance the GEOSS Common Infrastructure (GCI) providing the user community with innovative quality-aware search and evaluation tools, which will be integrated in the GEO-Portal, as well as made available to other end-user interfaces. To this end, GeoViQua will promote the extension of the current standard metadata for geographic information with accurate and expressive quality indicators, also contributing to the definition of a quality label (GEOLabel). GeoViQua proposed solutions will be assessed in several pilot case studies covering the whole Earth Observation chain, from remote sensing acquisition to data processing, to applications in the main GEOSS Societal Benefit Areas. This work presents the preliminary results of GeoViQua Work Package 4 "Enhanced geo-search tools" (WP4), started in January 2012. Its major anticipated technical innovations are search and evaluation tools that communicate and exploit data quality information from the GCI. In particular, GeoViQua will investigate a graphical search interface featuring a coherent and meaningful aggregation of statistics and metadata summaries (e.g. in the form of tables, charts), thus enabling end users to leverage quality constraints for data discovery and evaluation. Preparatory work on WP4 requirements indicated that users need the "best" data for their purpose, implying a high degree of subjectivity in judgment. This suggests that the GeoViQua system should exploit a combination of provider-generated metadata (objective indicators such as summary statistics), system-generated metadata (contextual/tracking information such as provenance of data and metadata), and user-generated metadata (informal user comments, usage information, rating, etc.). Moreover, metadata should include sufficiently complete access information, to allow rich data visualization and propagation. The following main enabling components are currently identified within WP4: - Quality-aware access services, e.g. a quality-aware extension of the OGC Sensor Observation Service (SOS-Q) specification, to support quality constraints for sensor data publishing and access; - Quality-aware discovery services, namely a quality-aware extension of the OGC Catalog Service for the Web (CSW-Q), to cope with quality constrained search; - Quality-augmentation broker (GeoViQua Broker), to support the linking and combination of the existing GCI metadata with GeoViQua- and user-generated metadata required to support the users in selecting the "best" data for their intended use. We are currently developing prototypes of the above quality-enabled geo-search components, that will be assessed in a sensor-based pilot case study in the next months. In particular, the GeoViQua Broker will be integrated with the EuroGEOSS Broker, to implement CSW-Q and federate (either via distribution or harvesting schemes) quality-aware data sources, GeoViQua will constitute a valuable test-bed for advancing the current best practices and standards in geospatial quality representation and exploitation. The research leading to these results has received funding from the European Community's Seventh Framework Programme (FP7/2007-2013) under Grant Agreement n° 265178.

Tectonic evolution and extension at the Møre Margin - Offshore mid-Norway

NASA Astrophysics Data System (ADS)

Theissen-Krah, S.; Zastrozhnov, D.; Abdelmalak, M. M.; Schmid, D. W.; Faleide, J. I.; Gernigon, L.

2017-11-01

Lithospheric stretching is the key process in forming extensional sedimentary basins at passive rifted margins. This study explores the stretching factors, resulting extension, and structural evolution of the Møre segment on the Mid-Norwegian continental margin. Based on the interpretation of new and reprocessed high-quality seismic, we present updated structural maps of the Møre margin that show very thick post-rift sediments in the central Møre Basin and extensive sill intrusion into the Cretaceous sediments. A major shift in subsidence and deposition occurred during mid-Cretaceous. One transect across the Møre continental margin from the Slørebotn Subbasin to the continent-ocean boundary is reconstructed using the basin modelling software TecMod. We test different initial crustal configurations and rifting events and compare our structural reconstruction results to stretching factors derived both from crustal thinning and the classical backstripping/decompaction approach. Seismic interpretation in combination with structural reconstruction modelling does not support the lower crustal bodies as exhumed and serpentinised mantle. Our extension estimate along this transect is 188 ± 28 km for initial crustal thickness varying between 30 and 40 km.

Power Extension Package (PEP) system definition extension, orbital service module systems analysis study. Volume 4: PEP functional specification

NASA Technical Reports Server (NTRS)

1979-01-01

The functional, performance, design, and test requirements for the Orbiter power extension package and its associated ground support equipment are defined. Both government and nongovernment standards and specifications are cited for the following subsystems: electrical power, structural/mechanical, avionics, and thermal control. Quality control assurance provisions and preparation for delivery are also discussed.

Study on electroplating technology of diamond tools for machining hard and brittle materials

NASA Astrophysics Data System (ADS)

Cui, Ying; Chen, Jian Hua; Sun, Li Peng; Wang, Yue

2016-10-01

With the development of the high speed cutting, the ultra-precision machining and ultrasonic vibration technique in processing hard and brittle material , the requirement of cutting tools is becoming higher and higher. As electroplated diamond tools have distinct advantages, such as high adaptability, high durability, long service life and good dimensional stability, the cutting tools are effective and extensive used in grinding hard and brittle materials. In this paper, the coating structure of electroplating diamond tool is described. The electroplating process flow is presented, and the influence of pretreatment on the machining quality is analyzed. Through the experimental research and summary, the reasonable formula of the electrolyte, the electroplating technologic parameters and the suitable sanding method were determined. Meanwhile, the drilling experiment on glass-ceramic shows that the electroplating process can effectively improve the cutting performance of diamond tools. It has laid a good foundation for further improving the quality and efficiency of the machining of hard and brittle materials.

Melter Throughput Enhancements for High-Iron HLW

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kruger, A. A.; Gan, Hoa; Joseph, Innocent

2012-12-26

This report describes work performed to develop and test new glass and feed formulations in order to increase glass melting rates in high waste loading glass formulations for HLW with high concentrations of iron. Testing was designed to identify glass and melter feed formulations that optimize waste loading and waste processing rate while meeting all processing and product quality requirements. The work included preparation and characterization of crucible melts to assess melt rate using a vertical gradient furnace system and to develop new formulations with enhanced melt rate. Testing evaluated the effects of waste loading on glass properties and themore » maximum waste loading that can be achieved. The results from crucible-scale testing supported subsequent DuraMelter 100 (DM100) tests designed to examine the effects of enhanced glass and feed formulations on waste processing rate and product quality. The DM100 was selected as the platform for these tests due to its extensive previous use in processing rate determination for various HLW streams and glass compositions.« less

77 FR 46750 - Agency Information Collection Extension

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-06

... Questionnaire Testing, Evaluation, and Research.'' The proposed collection will utilize qualitative and quantitative methodologies to pretest questionnaires and validate EIA survey forms data quality, including..., Evaluation, and Research; (3) Type of Request: Extension, Without Change, of a Previously Approved Collection...

Some far-field acoustics characteristics of the XV-15 tilt-rotor aircraft

NASA Technical Reports Server (NTRS)

Golub, Robert A.; Conner, David A.; Becker, Lawrence E.; Rutledge, C. Kendall; Smith, Rita A.

1990-01-01

Far-field acoustics tests have been conducted on an instrumented XV-15 tilt-rotor aircraft. The purpose of these acoustic measurements was to create an encompassing, high confidence (90 percent), and accurate (-1.4/ +1/8 dB theoretical confidence interval) far-field acoustics data base to validate ROTONET and other current rotorcraft noise prediction computer codes. This paper describes the flight techniques used, with emphasis on the care taken to obtain high-quality far-field acoustic data. The quality and extensiveness of the data base collected are shown by presentation of ground acoustic contours for level flyovers for the airplane flight mode and for several forward velocities and nacelle tilts for the transition mode and helicopter flight mode. Acoustic pressure time-histories and fully analyzed ensemble averaged far-field data results (spectra) are shown for each of the ground contour cases.

Subjective evaluation of next-generation video compression algorithms: a case study

NASA Astrophysics Data System (ADS)

De Simone, Francesca; Goldmann, Lutz; Lee, Jong-Seok; Ebrahimi, Touradj; Baroncini, Vittorio

2010-08-01

This paper describes the details and the results of the subjective quality evaluation performed at EPFL, as a contribution to the effort of the Joint Collaborative Team on Video Coding (JCT-VC) for the definition of the next-generation video coding standard. The performance of 27 coding technologies have been evaluated with respect to two H.264/MPEG-4 AVC anchors, considering high definition (HD) test material. The test campaign involved a total of 494 naive observers and took place over a period of four weeks. While similar tests have been conducted as part of the standardization process of previous video coding technologies, the test campaign described in this paper is by far the most extensive in the history of video coding standardization. The obtained subjective quality scores show high consistency and support an accurate comparison of the performance of the different coding solutions.

MetaSort untangles metagenome assembly by reducing microbial community complexity

PubMed Central

Ji, Peifeng; Zhang, Yanming; Wang, Jinfeng; Zhao, Fangqing

2017-01-01

Most current approaches to analyse metagenomic data rely on reference genomes. Novel microbial communities extend far beyond the coverage of reference databases and de novo metagenome assembly from complex microbial communities remains a great challenge. Here we present a novel experimental and bioinformatic framework, metaSort, for effective construction of bacterial genomes from metagenomic samples. MetaSort provides a sorted mini-metagenome approach based on flow cytometry and single-cell sequencing methodologies, and employs new computational algorithms to efficiently recover high-quality genomes from the sorted mini-metagenome by the complementary of the original metagenome. Through extensive evaluations, we demonstrated that metaSort has an excellent and unbiased performance on genome recovery and assembly. Furthermore, we applied metaSort to an unexplored microflora colonized on the surface of marine kelp and successfully recovered 75 high-quality genomes at one time. This approach will greatly improve access to microbial genomes from complex or novel communities. PMID:28112173

A High-Performance Genetic Algorithm: Using Traveling Salesman Problem as a Case

PubMed Central

Tsai, Chun-Wei; Tseng, Shih-Pang; Yang, Chu-Sing

2014-01-01

This paper presents a simple but efficient algorithm for reducing the computation time of genetic algorithm (GA) and its variants. The proposed algorithm is motivated by the observation that genes common to all the individuals of a GA have a high probability of surviving the evolution and ending up being part of the final solution; as such, they can be saved away to eliminate the redundant computations at the later generations of a GA. To evaluate the performance of the proposed algorithm, we use it not only to solve the traveling salesman problem but also to provide an extensive analysis on the impact it may have on the quality of the end result. Our experimental results indicate that the proposed algorithm can significantly reduce the computation time of GA and GA-based algorithms while limiting the degradation of the quality of the end result to a very small percentage compared to traditional GA. PMID:24892038

A high-performance genetic algorithm: using traveling salesman problem as a case.

PubMed

Tsai, Chun-Wei; Tseng, Shih-Pang; Chiang, Ming-Chao; Yang, Chu-Sing; Hong, Tzung-Pei

2014-01-01

This paper presents a simple but efficient algorithm for reducing the computation time of genetic algorithm (GA) and its variants. The proposed algorithm is motivated by the observation that genes common to all the individuals of a GA have a high probability of surviving the evolution and ending up being part of the final solution; as such, they can be saved away to eliminate the redundant computations at the later generations of a GA. To evaluate the performance of the proposed algorithm, we use it not only to solve the traveling salesman problem but also to provide an extensive analysis on the impact it may have on the quality of the end result. Our experimental results indicate that the proposed algorithm can significantly reduce the computation time of GA and GA-based algorithms while limiting the degradation of the quality of the end result to a very small percentage compared to traditional GA.

Development and validation of the RapidHIT™ 200 utilising NGMSElect™ Express for the processing of buccal swabs.

PubMed

Shackleton, David; Pagram, Jenny; Ives, Lesley; Vanhinsbergh, Des

2018-06-02

The RapidHIT™ 200 System is a fully automated sample-to-DNA profile system designed to produce high quality DNA profiles within 2h. The use of RapidHIT™ 200 System within the United Kingdom Criminal Justice System (UKCJS) has required extensive development and validation of methods with a focus on AmpFℓSTR ® NGMSElect™ Express PCR kit to comply with specific regulations for loading to the UK National DNA Database (NDNAD). These studies have been carried out using single source reference samples to simulate live reference samples taken from arrestees and victims for elimination. The studies have shown that the system is capable of generating high quality profile and has achieved the accreditations necessary to load to the NDNAD; a first for the UK. Copyright © 2018 Elsevier B.V. All rights reserved.

Continuous Spectrum LEDs Promote Seedling Quality Traits and Performance of Quercus ithaburensis var. macrolepis

PubMed Central

Smirnakou, Sonia; Ouzounis, Theoharis; Radoglou, Kalliopi M.

2017-01-01

Regulation of the growth, development, and quality of plants by the control of light quality has attracted extensive attention worldwide. The aim of this study was to examine the effects of continuous LED spectrum for indoor plant pre-cultivation and to investigate the morphological and physiological responses of a common broadleaved tree species in Mediterranean environment, Quercus ithaburensis var. macrolepis at seedling developmental stage. Thus, the seedlings were pre-cultivated for 28 days, under five different LED light qualities: (1) Fluorescent (FL) as control light (2) L20AP67 (high in green and moderate in far-red), (3) AP673L (high in green and red), (4) G2 (highest in red and far-red), AP67 (high in blue, red, and far-red), and (5) NS1 (highest in blue and green and lowest in far-red) LEDs. Further examination was held at the nursery for 1 year, on several seedling quality traits. Indeed, AP67 and AP673L triggered higher leaf formation, while L20AP67 positively affected seedling shoot development. NS1 and AP67 LED pre-cultivated seedlings showed significantly higher root fibrosity than those of FL light. Furthermore, NS1 and AP673L LEDs induced fourfold increase on seedling root dry weight than FL light. Hence, evaluating the seedling nursery performance attributes, most of those photomorphogenetic responses previously obtained were still detectable. Even more so, LED pre-cultivated seedlings showed higher survival and faster growth indicating better adaptation even under natural light conditions, a fact further reinforced by the significantly higher Dickson’s quality index acquired. In conclusion, the goal of each nursery management program is the production of high quality seedlings with those desirable traits, which in turn satisfy the specific needs for a particular reforestation site. Thus, the enhanced oak seedling quality traits formed under continuous LEDs spectrum especially of NS1 and AP673L pre-cultivation may potentially fulfill this goal. PMID:28261244

7 CFR 634.1 - Purpose and scope.

Code of Federal Regulations, 2011 CFR

2011-01-01

... best management practices (BMP's) in project areas which have critical water quality problems resulting... approved agricultural portion of a 208 water quality management plan. Participation in RCWP is voluntary. (c) The program is a new USDA program and an extension of existing water-quality management programs...

7 CFR 634.1 - Purpose and scope.

Code of Federal Regulations, 2010 CFR

2010-01-01

... best management practices (BMP's) in project areas which have critical water quality problems resulting... approved agricultural portion of a 208 water quality management plan. Participation in RCWP is voluntary. (c) The program is a new USDA program and an extension of existing water-quality management programs...

An investigation of the effects of pitch-roll (de)coupling on helicopter handling qualities

NASA Technical Reports Server (NTRS)

Blanken, C. L.; Pausder, H. J.; Ockier, C. J.

1995-01-01

An extensive investigation of the effects of pitch-roll coupling on helicopter handling qualities was performed by the U.S. Army and Deutsche Forschungsanstalt fur Luft- und Raumfahrt (DLR), using a NASA ground-based and a DLR in-flight simulator. Over 90 different coupling configurations were evaluated using a high gain roll-axis tracking task. The results show that although the current ADS-33C coupling criterion discriminates against those types of coupling typical of conventionally controlled helicopters, it is not always suited for the prediction of handling qualities of helicopters with modern control systems. Based on the observation that high frequency inputs during tracking are used to alleviate coupling, a frequency domain pitch-roll coupling criterion that uses the average coupling ratio between the bandwidth and neutral stability frequency is formulated. This criterion provides a more comprehensive coverage with respect to the different types of coupling, shows excellent consistency, and has the additional benefit that compliance testing data are obtained from the bandwidth/phase delay tests, so that no additional flight testing is needed.

Image Improvement Techniques

NASA Astrophysics Data System (ADS)

Shine, R. A.

1997-05-01

Over the last decade, a repertoire of techniques have been developed and/or refined to improve the quality of high spatial resolution solar movies taken from ground based observatories. These include real time image motion corrections, frame selection, phase diversity measurements of the wavefront, and extensive post processing to partially remove atmospheric distortion. Their practical application has been made possible by the increasing availability and decreasing cost of large CCD's with fast digital readouts and high speed computer workstations with large memories. Most successful have been broad band (0.3 to 10 nm) filtergram movies which can use exposure times of 10 to 30 ms, short enough to ``freeze'' atmospheric motions. Even so, only a handful of movies with excellent image quality for more than a hour have been obtained to date. Narrowband filtergrams (about 0.01 nm), such as those required for constructing magnetograms and Dopplergrams, have been more challenging although some single images approach the quality of the best continuum images. Some promising new techniques and instruments, together with persistence and good luck, should continue the progress made in the last several years.

Robust model-based 3d/3D fusion using sparse matching for minimally invasive surgery.

PubMed

Neumann, Dominik; Grbic, Sasa; John, Matthias; Navab, Nassir; Hornegger, Joachim; Ionasec, Razvan

2013-01-01

Classical surgery is being disrupted by minimally invasive and transcatheter procedures. As there is no direct view or access to the affected anatomy, advanced imaging techniques such as 3D C-arm CT and C-arm fluoroscopy are routinely used for intra-operative guidance. However, intra-operative modalities have limited image quality of the soft tissue and a reliable assessment of the cardiac anatomy can only be made by injecting contrast agent, which is harmful to the patient and requires complex acquisition protocols. We propose a novel sparse matching approach for fusing high quality pre-operative CT and non-contrasted, non-gated intra-operative C-arm CT by utilizing robust machine learning and numerical optimization techniques. Thus, high-quality patient-specific models can be extracted from the pre-operative CT and mapped to the intra-operative imaging environment to guide minimally invasive procedures. Extensive quantitative experiments demonstrate that our model-based fusion approach has an average execution time of 2.9 s, while the accuracy lies within expert user confidence intervals.

Climate Change Impact on Air Quality in High Resolution Simulation for Central Europe

NASA Astrophysics Data System (ADS)

Halenka, T.; Huszar, P.; Belda, M.

2009-04-01

Recently the effects of climate change on air-quality and vice-versa are studied quite extensively. In fact, even at regional and local scale especially the impact of climate change on the atmospheric composition and photochemical smog formation conditions can be significant when expecting e.g. more frequent appearance of heat waves etc. For the purpose of qualifying and quantifying the magnitude of such effects and to study the potential of climate forcing due to atmospheric chemistry/aerosols on regional scale, chemistry-transport model was coupled to RegCM on the Department of Meteorology and Environmental Protection, Faculty of Mathematics and Physics, Charles University in Prague, for the simulations in framework of the EC FP6 Project CECILIA. Off-line one way coupling enables the simulation of distribution of pollutants over 1991-2001 in very high resolution of 10 km is compared to the EMEP observations for the area of Central Europe. Simulations driven by climate change boundary conditions for time slices 1991-2000, 2041-2050 and 2091-2100 are presented to show the effect of climate change on the air quality in the region.

LED Lighting – Modification of Growth, Metabolism, Yield and Flour Composition in Wheat by Spectral Quality and Intensity

PubMed Central

Monostori, István; Heilmann, Márk; Kocsy, Gábor; Rakszegi, Marianna; Ahres, Mohamed; Altenbach, Susan B.; Szalai, Gabriella; Pál, Magda; Toldi, Dávid; Simon-Sarkadi, Livia; Harnos, Noémi; Galiba, Gábor; Darko, Éva

2018-01-01

The use of light-emitting diode (LED) technology for plant cultivation under controlled environmental conditions can result in significant reductions in energy consumption. However, there is still a lack of detailed information on the lighting conditions required for optimal growth of different plant species and the effects of light intensity and spectral composition on plant metabolism and nutritional quality. In the present study, wheat plants were grown under six regimens designed to compare the effects of LED and conventional fluorescent lights on growth and development, leaf photosynthesis, thiol and amino acid metabolism as well as grain yield and flour quality of wheat. Benefits of LED light sources over fluorescent lighting were manifested in both yield and quality of wheat. Elevated light intensities made possible with LEDs increased photosynthetic activity, the number of tillers, biomass and yield. At lower light intensities, blue, green and far-red light operated antagonistically during the stem elongation period. High photosynthetic activity was achieved when at least 50% of red light was applied during cultivation. A high proportion of blue light prolonged the juvenile phase, while the shortest flowering time was achieved when the blue to red ratio was around one. Blue and far-red light affected the glutathione- and proline-dependent redox environment in leaves. LEDs, especially in Blue, Pink and Red Low Light (RedLL) regimens improved flour quality by modifying starch and protein content, dough strength and extensibility as demonstrated by the ratios of high to low molecular weight glutenins, ratios of glutenins to gliadins and gluten spread values. These results clearly show that LEDs are efficient for experimental wheat cultivation, and make it possible to optimize the growth conditions and to manipulate metabolism, yield and quality through modification of light quality and quantity. PMID:29780400

LED Lighting - Modification of Growth, Metabolism, Yield and Flour Composition in Wheat by Spectral Quality and Intensity.

PubMed

Monostori, István; Heilmann, Márk; Kocsy, Gábor; Rakszegi, Marianna; Ahres, Mohamed; Altenbach, Susan B; Szalai, Gabriella; Pál, Magda; Toldi, Dávid; Simon-Sarkadi, Livia; Harnos, Noémi; Galiba, Gábor; Darko, Éva

2018-01-01

The use of light-emitting diode (LED) technology for plant cultivation under controlled environmental conditions can result in significant reductions in energy consumption. However, there is still a lack of detailed information on the lighting conditions required for optimal growth of different plant species and the effects of light intensity and spectral composition on plant metabolism and nutritional quality. In the present study, wheat plants were grown under six regimens designed to compare the effects of LED and conventional fluorescent lights on growth and development, leaf photosynthesis, thiol and amino acid metabolism as well as grain yield and flour quality of wheat. Benefits of LED light sources over fluorescent lighting were manifested in both yield and quality of wheat. Elevated light intensities made possible with LEDs increased photosynthetic activity, the number of tillers, biomass and yield. At lower light intensities, blue, green and far-red light operated antagonistically during the stem elongation period. High photosynthetic activity was achieved when at least 50% of red light was applied during cultivation. A high proportion of blue light prolonged the juvenile phase, while the shortest flowering time was achieved when the blue to red ratio was around one. Blue and far-red light affected the glutathione- and proline-dependent redox environment in leaves. LEDs, especially in Blue, Pink and Red Low Light (RedLL) regimens improved flour quality by modifying starch and protein content, dough strength and extensibility as demonstrated by the ratios of high to low molecular weight glutenins, ratios of glutenins to gliadins and gluten spread values. These results clearly show that LEDs are efficient for experimental wheat cultivation, and make it possible to optimize the growth conditions and to manipulate metabolism, yield and quality through modification of light quality and quantity.

Report of reprocessing of reflection seismic profile X-5 Waste Isolation Pilot Plant site, Eddy County, New Mexico

USGS Publications Warehouse

Miller, John J.

1983-01-01

Seismic reflection profile X-5 exhibits a 7,700 ft long anomalous zone of poor quality to nonexistent reflections between shotpoints 100 and 170, compared to the high-quality, flat-lying, coherent reflections on either side. Results from drill holes in the area suggest 'layer cake' geology with no detectable abnormalities such as faults present. In an attempt to determine whether the anomalous zone of the seismic profile is an artifact or actually indicates a geologic condition, the data were extensively reprocessed using state-of-the-art processing techniques and the following conclusions were made: 1. The field-recorded data in the anomalous zone are of poor quality due to surface conditions and recording parameters used. 2. Reprocessing shows reflectors throughout the anomalous zone at all levels. However, it cannot prove that the reflectors are continuous throughout the anomalous zone. 3. Significant improvement in data quality may be achieved if the line is reshot using carefully determined recording parameters.

Variation in the health and biochemical condition of the coral Acropora tenuis along two water quality gradients on the Great Barrier Reef, Australia.

PubMed

Rocker, Melissa M; Francis, David S; Fabricius, Katharina E; Willis, Bette L; Bay, Line K

2017-06-30

This study explores how plasticity in biochemical attributes, used as indicators of health and condition, enables the coral Acropora tenuis to respond to differing water quality regimes in inshore regions of the Great Barrier Reef. Health attributes were monitored along a strong and weak water quality gradient, each with three reefs at increasing distances from a major river source. Attributes differed significantly only along the strong gradient; corals grew fastest, had the least dense skeletons, highest symbiont densities and highest lipid concentrations closest to the river mouth, where water quality was poorest. High nutrient and particulate loads were only detrimental to skeletal density, which decreased as linear extension increased, highlighting a trade-off. Our study underscores the importance of assessing multiple health attributes in coral reef monitoring. For example, autotrophic indices are poor indicators of coral health and condition, but improve when combined with attributes like lipid content and biomass. Copyright © 2017 Elsevier Ltd. All rights reserved.

Three-dimensional propagation in near-field tomographic X-ray phase retrieval

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ruhlandt, Aike, E-mail: aruhlan@gwdg.de; Salditt, Tim

An extension of phase retrieval algorithms for near-field X-ray (propagation) imaging to three dimensions is presented, enhancing the quality of the reconstruction by exploiting previously unused three-dimensional consistency constraints. This paper presents an extension of phase retrieval algorithms for near-field X-ray (propagation) imaging to three dimensions, enhancing the quality of the reconstruction by exploiting previously unused three-dimensional consistency constraints. The approach is based on a novel three-dimensional propagator and is derived for the case of optically weak objects. It can be easily implemented in current phase retrieval architectures, is computationally efficient and reduces the need for restrictive prior assumptions, resultingmore » in superior reconstruction quality.« less

FQC Dashboard: integrates FastQC results into a web-based, interactive, and extensible FASTQ quality control tool.

PubMed

Brown, Joseph; Pirrung, Meg; McCue, Lee Ann

2017-06-09

FQC is software that facilitates quality control of FASTQ files by carrying out a QC protocol using FastQC, parsing results, and aggregating quality metrics into an interactive dashboard designed to richly summarize individual sequencing runs. The dashboard groups samples in dropdowns for navigation among the data sets, utilizes human-readable configuration files to manipulate the pages and tabs, and is extensible with CSV data. FQC is implemented in Python 3 and Javascript, and is maintained under an MIT license. Documentation and source code is available at: https://github.com/pnnl/fqc . joseph.brown@pnnl.gov. © The Author(s) 2017. Published by Oxford University Press.

Drifts in ADCC-related quality attributes of Herceptin®: Impact on development of a trastuzumab biosimilar.

PubMed

Kim, Seokkyun; Song, Jinsu; Park, Seungkyu; Ham, Sunyoung; Paek, Kyungyeol; Kang, Minjung; Chae, Yunjung; Seo, Heewon; Kim, Hyung-Chan; Flores, Michael

A biosimilar product needs to demonstrate biosimilarity to the originator reference product, and the quality profile of the latter should be monitored throughout the period of the biosimilar's development to match the quality attributes of the 2 products that relate to efficacy and safety. For the development of a biosimilar version of trastuzumab, the reference product, Herceptin®, was extensively characterized for the main physicochemical and biologic properties by standard or state-of-the-art analytical methods, using multiple lots expiring between March 2015 and December 2019. For lots with expiry dates up to July 2018, a high degree of consistency was observed for all the tested properties. However, among the lots expiring in August 2018 or later, a downward drift was observed in %afucose (G0+G1+G2). Furthermore, the upward drift of %high mannose (M5+M6) was observed in the lots with expiry dates from June 2019 to December 2019. As a result, the combination of %afucose and %high mannose showed 2 marked drifts in the lots with expiry dates from August 2018 to December 2019, which was supported by the similar trend of biologic data, such as FcγRIIIa binding and antibody-dependent cell-mediated cytotoxicity (ADCC) activity. Considering that ADCC is one of the clinically relevant mechanisms of action for trastuzumab, the levels of %afucose and %high mannose should be tightly monitored as critical quality attributes for biosimilar development of trastuzumab.

Drifts in ADCC-related quality attributes of Herceptin®: Impact on development of a trastuzumab biosimilar

PubMed Central

Kim, Seokkyun; Song, Jinsu; Park, Seungkyu; Ham, Sunyoung; Paek, Kyungyeol; Kang, Minjung; Chae, Yunjung; Seo, Heewon; Kim, Hyung-Chan; Flores, Michael

2017-01-01

ABSTRACT A biosimilar product needs to demonstrate biosimilarity to the originator reference product, and the quality profile of the latter should be monitored throughout the period of the biosimilar's development to match the quality attributes of the 2 products that relate to efficacy and safety. For the development of a biosimilar version of trastuzumab, the reference product, Herceptin®, was extensively characterized for the main physicochemical and biologic properties by standard or state-of-the-art analytical methods, using multiple lots expiring between March 2015 and December 2019. For lots with expiry dates up to July 2018, a high degree of consistency was observed for all the tested properties. However, among the lots expiring in August 2018 or later, a downward drift was observed in %afucose (G0+G1+G2). Furthermore, the upward drift of %high mannose (M5+M6) was observed in the lots with expiry dates from June 2019 to December 2019. As a result, the combination of %afucose and %high mannose showed 2 marked drifts in the lots with expiry dates from August 2018 to December 2019, which was supported by the similar trend of biologic data, such as FcγRIIIa binding and antibody-dependent cell-mediated cytotoxicity (ADCC) activity. Considering that ADCC is one of the clinically relevant mechanisms of action for trastuzumab, the levels of %afucose and %high mannose should be tightly monitored as critical quality attributes for biosimilar development of trastuzumab. PMID:28296619

Influence of high latitude light conditions on sensory quality and contents of health and sensory-related compounds in swede roots (Brassica napus L. ssp. rapifera Metzg.).

PubMed

Mølmann, Jørgen Ab; Hagen, Sidsel Fiskaa; Bengtsson, Gunnar B; Johansen, Tor J

2018-02-01

Vegetable growers in Arctic areas must increasingly rely on market strategies based on regional origin and product quality. Swede roots (rutabaga) were grown in a phytotron to investigate the effect of high latitude light conditions on sensory quality and some health and sensory-related compounds. Experimental treatments included modifications of 24 h natural day length (69° 39' N) by moving plants at daily intervals to dark chambers with either no light, fluorescent growth light and/or low intensity photoperiod extension. Shortening the photosynthetic light period to 12 h produced smaller roots than 15.7 h and 18 h, with highest scores for bitter and sulfur taste, and lowest scores for sweetness, acidic taste and fibrousness. The photoperiod in combination with the photosynthetic light period also had an influence on glucosinolate (GLS) contents, with lowest concentrations in 24 h natural light and highest in 12 h natural light. Concentrations of vitamin C, glucose, fructose and sucrose were not significantly influenced by any of the treatments. High latitude light conditions, with long photosynthetic light periods and 24 h photoperiod, can enhance sweet/less bitter taste and reduce GLS contents in swede roots, compared to growth under short day conditions. This influence of light conditions on eating quality may benefit marketing of regional products from high latitudes. © 2017 Society of Chemical Industry. © 2017 Society of Chemical Industry.

Impact of emissions from natural gas production facilities on ambient air quality in the Barnett Shale area: a pilot study.

PubMed

Zielinska, Barbara; Campbell, Dave; Samburova, Vera

2014-12-01

Rapid and extensive development of shale gas resources in the Barnett Shale region of Texas in recent years has created concerns about potential environmental impacts on water and air quality. The purpose of this study was to provide a better understanding of the potential contributions of emissions from gas production operations to population exposure to air toxics in the Barnett Shale region. This goal was approached using a combination of chemical characterization of the volatile organic compound (VOC) emissions from active wells, saturation monitoring for gaseous and particulate pollutants in a residential community located near active gas/oil extraction and processing facilities, source apportionment of VOCs measured in the community using the Chemical Mass Balance (CMB) receptor model, and direct measurements of the pollutant gradient downwind of a gas well with high VOC emissions. Overall, the study results indicate that air quality impacts due to individual gas wells and compressor stations are not likely to be discernible beyond a distance of approximately 100 m in the downwind direction. However, source apportionment results indicate a significant contribution to regional VOCs from gas production sources, particularly for lower-molecular-weight alkanes (< C6). Although measured ambient VOC concentrations were well below health-based safe exposure levels, the existence of urban-level mean concentrations of benzene and other mobile source air toxics combined with soot to total carbon ratios that were high for an area with little residential or commercial development may be indicative of the impact of increased heavy-duty vehicle traffic related to gas production. Implications: Rapid and extensive development of shale gas resources in recent years has created concerns about potential environmental impacts on water and air quality. This study focused on directly measuring the ambient air pollutant levels occurring at residential properties located near natural gas extraction and processing facilities, and estimating the relative contributions from gas production and motor vehicle emissions to ambient VOC concentrations. Although only a small-scale case study, the results may be useful for guidance in planning future ambient air quality studies and human exposure estimates in areas of intensive shale gas production.

Non-toric extended depth of focus contact lenses for astigmatism and presbyopia correction

NASA Astrophysics Data System (ADS)

Ben Yaish, Shai; Zlotnik, Alex; Yehezkel, Oren; Lahav-Yacouel, Karen; Belkin, Michael; Zalevsky, Zeev

2010-02-01

Purpose: Testing whether the extended depth of focus technology embedded on non-toric contact lenses is a suitable treatment for both astigmatism and presbyopia. Methods: The extended depth of focus pattern consisting of microndepth concentric grooves was engraved on a surface of a mono-focal soft contact lens. These grooves create an interference pattern extending the focus from a point to a length of about 1mm providing a 3.00D extension in the depth of focus. The extension in the depth of focus provides high quality focused imaging capabilities from near through intermediate and up to far ranges. Due to the angular symmetry of the engraved pattern the extension in the depth of focus can also resolve regular as well as irregular astigmatism aberrations. Results: The contact lens was tested on a group of 8 astigmatic and 13 subjects with presbyopia. Average correction of 0.70D for astigmatism and 1.50D for presbyopia was demonstrated. Conclusions: The extended depth of focus technology in a non-toric contact lens corrects simultaneously astigmatism and presbyopia. The proposed solution is based upon interference rather than diffraction effects and thus it is characterized by high energetic efficiency to the retina plane as well as reduced chromatic aberrations.

Problems Impacting Extension Program Quality at the County Level: Results from an Analysis of County Program Reviews Conducted in Florida

ERIC Educational Resources Information Center

Harder, Amy; Moore, Austen; Mazurkewicz, Melissa; Benge, Matt

2013-01-01

Needs assessments are an important tool for informing organizational development efforts in Extension. The purpose of the study reported here was to identify problems faced by county units within UF/IFAS Extension during county program reviews. The findings were drawn from the reports created after five county units experienced program reviews in…

Revitalizing the Rural South. Extension's Role in Enhancing the Quality of Life. Proceedings of a Regional Conference (Birmingham, Alabama, January 16-18, 1990).

ERIC Educational Resources Information Center

Southern Rural Development Center, Mississippi State, MS.

Cooperative Extension Service personnel from 13 Southern states attended a conference on rural revitalization, focusing on Extension's role in (1) economic development, (2) human capital, and (3) infrastructure; 17 of the 22 papers presented are divided among those categories. Three of the remaining papers provide respectively, an overview of the…

Functional magnetic resonance imaging of awake monkeys: some approaches for improving imaging quality

PubMed Central

Chen, Gang; Wang, Feng; Dillenburger, Barbara C.; Friedman, Robert M.; Chen, Li M.; Gore, John C.; Avison, Malcolm J.; Roe, Anna W.

2011-01-01

Functional magnetic resonance imaging (fMRI), at high magnetic field strength can suffer from serious degradation of image quality because of motion and physiological noise, as well as spatial distortions and signal losses due to susceptibility effects. Overcoming such limitations is essential for sensitive detection and reliable interpretation of fMRI data. These issues are particularly problematic in studies of awake animals. As part of our initial efforts to study functional brain activations in awake, behaving monkeys using fMRI at 4.7T, we have developed acquisition and analysis procedures to improve image quality with encouraging results. We evaluated the influence of two main variables on image quality. First, we show how important the level of behavioral training is for obtaining good data stability and high temporal signal-to-noise ratios. In initial sessions, our typical scan session lasted 1.5 hours, partitioned into short (<10 minutes) runs. During reward periods and breaks between runs, the monkey exhibited movements resulting in considerable image misregistrations. After a few months of extensive behavioral training, we were able to increase the length of individual runs and the total length of each session. The monkey learned to wait until the end of a block for fluid reward, resulting in longer periods of continuous acquisition. Each additional 60 training sessions extended the duration of each session by 60 minutes, culminating, after about 140 training sessions, in sessions that last about four hours. As a result, the average translational movement decreased from over 500 μm to less than 80 μm, a displacement close to that observed in anesthetized monkeys scanned in a 7 T horizontal scanner. Another major source of distortion at high fields arises from susceptibility variations. To reduce such artifacts, we used segmented gradient-echo echo-planar imaging (EPI) sequences. Increasing the number of segments significantly decreased susceptibility artifacts and image distortion. Comparisons of images from functional runs using four segments with those using a single-shot EPI sequence revealed a roughly two-fold improvement in functional signal-to-noise-ratio and 50% decrease in distortion. These methods enabled reliable detection of neural activation and permitted blood-oxygenation-level-dependent (BOLD) based mapping of early visual areas in monkeys using a volume coil. In summary, both extensive behavioral training of monkeys and application of segmented gradient-echo EPI sequence improved signal-to-noise and image quality. Understanding the effects these factors have is important for the application of high field imaging methods to the detection of sub-millimeter functional structures in the awake monkey brain. PMID:22055855

HEVC real-time decoding

NASA Astrophysics Data System (ADS)

Bross, Benjamin; Alvarez-Mesa, Mauricio; George, Valeri; Chi, Chi Ching; Mayer, Tobias; Juurlink, Ben; Schierl, Thomas

2013-09-01

The new High Efficiency Video Coding Standard (HEVC) was finalized in January 2013. Compared to its predecessor H.264 / MPEG4-AVC, this new international standard is able to reduce the bitrate by 50% for the same subjective video quality. This paper investigates decoder optimizations that are needed to achieve HEVC real-time software decoding on a mobile processor. It is shown that HEVC real-time decoding up to high definition video is feasible using instruction extensions of the processor while decoding 4K ultra high definition video in real-time requires additional parallel processing. For parallel processing, a picture-level parallel approach has been chosen because it is generic and does not require bitstreams with special indication.

Advanced Capabilities for Wind Tunnel Testing in the 21st Century

NASA Technical Reports Server (NTRS)

Kegelman, Jerome T.; Danehy, Paul M.; Schwartz, Richard J.

2010-01-01

Wind tunnel testing methods and test technologies for the 21st century using advanced capabilities are presented. These capabilities are necessary to capture more accurate and high quality test results by eliminating the uncertainties in testing and to facilitate verification of computational tools for design. This paper discusses near term developments underway in ground testing capabilities, which will enhance the quality of information of both the test article and airstream flow details. Also discussed is a selection of new capability investments that have been made to accommodate such developments. Examples include advanced experimental methods for measuring the test gas itself; using efficient experiment methodologies, including quality assurance strategies within the test; and increasing test result information density by using extensive optical visualization together with computed flow field results. These points could be made for both major investments in existing tunnel capabilities or for entirely new capabilities.

The quality of our Nation's waters: groundwater quality in the Columbia Plateau and Snake River Plain basin-fill and basaltic-rock aquifers and the Hawaiian volcanic-rock aquifers, Washington, Idaho, and Hawaii, 1993-2005

USGS Publications Warehouse

Rupert, Michael G.; Hunt, Charles D.; Skinner, Kenneth D.; Frans, Lonna M.; Mahler, Barbara J.

2015-01-01

The Columbia Plateau, Snake River Plain, and Hawaii are large volcanic areas in the western United States and mid-Pacific ocean that contain extensive regional aquifers of a hard, gray, volcanic rock called basalt. Residents of the Columbia Plateau, the Snake River Plain, and the island of Oahu depend on groundwater as their primary source of drinking water. Although the depth to the water table can be several hundred feet, the groundwater is highly vulnerable to contamination because the permeable sediments and rocks allow contaminants to move readily down to the water table. Intense agricultural and urban activities occur above the drinking-water supply and are increasing in some areas. Contaminants, such as nitrate, pesticides, and volatile organic compounds, associated with agricultural and urban activities, have adversely affected groundwater quality.

Participating despite questions: toward a more confident participatory technology assessment : commentary on: "Questioning 'participation': a critical appraisal of its conceptualization in a Flemish participatory technology assessment".

PubMed

Guston, David H

2011-12-01

While the important challenges of public deliberations on emerging technologies are crucial to keep in mind, this paper argues that scholars and practitioners have reason to be more confident in their performance of participatory technology assessments (pTA). Drawing on evidence from the 2008 National Citizens' Technology Forum (NCTF) conducted by the Center for Nanotechnology in Society at Arizona State University, this paper describes how pTA offers a combination of intensive and extensive qualities that are unique among modes of engagement. In the NCTF, this combination led to significant learning and opinion changes, based on what can be characterized as a high-quality deliberation. The quality of the anticipatory knowledge required to address emerging technologies is always contested, but pTAs can be designed with outcomes in mind-especially when learning is understood as an outcome.

Aircraft and satellite monitoring of water quality in Lake Superior near Duluth

NASA Technical Reports Server (NTRS)

Scherz, J. P.; Sydor, M.; Vandomelen, J. F.

1974-01-01

Satellite images and low altitude aerial photographs often show vivid discolorations in water bodies. Extensive laboratory analysis shows that water reflectance, which causes brightness on aerial images, positively correlates to the water quality parameter of turbidity, which on a particular day correlates to suspended solids. Work with low altitude photography on three overcast days and with ERTS images on five clear days provides positive correlation of image brightness to the high turbidity and solids which are present in Lake Superior near Duluth over 50% of the time. Proper use of aerial images would have shown that an $8,000,000 drinking water intake constructed in the midst of this unpotable, turbid water should have been located 6 miles north in clear, usable water. Noise effects such as skylight reflection, atmospheric effects, and depth penetration also must be understood for operational use of remote sensing for water quality monitoring and are considered in the paper.

Short-term variation in air quality associated with firework events: a case study.

PubMed

Ravindra, Khaiwal; Mor, Suman; Kaushik, C P

2003-04-01

The effect of fireworks on air quality was assessed from the ambient concentrations of various air pollutants (SO2, NO2, PM10 and TSP) during Diwali festival in Hisar city (India), in November 1999. The extensive use of fireworks was found to be related to short-term variation in air quality. During the festival the concentration of SO2 was observed to be increased approximately 10-fold at few sites, whereas the concentrations of NO2, PM10 and TSP increased 2-3 times, compared to the data collected on a typical winter day in December 1999. The maximum NO2 concentration was observed a day after the festival. The diurnal pattern of the above pollutants showed a slight increase in the night. The levels of these pollutants observed during Diwali were found to be moderately high, which can be associated with serious health impacts.

Study of Laser Drilled Hole Quality of Yttria Stabilized Zirconia

NASA Astrophysics Data System (ADS)

Saini, Surendra K.; Dubey, Avanish K.; Pant, Piyush; Upadhyay, B. N.; Choubey, A.

2017-09-01

The Yttria Stabilized Zirconia ceramic is extensively used in aerospace, automotives, medical and microelectronics industries. These applications demand manufacturing of different macro and micro features with close tolerances in this material. To make miniature holes with accurate dimensions in advanced ceramics such as Yttria Stabilized Zirconia is very difficult due to its tailored attributes such as high toughness, hardness, strength, resistance to wear, corrosion and temperature. Due to inherent characteristics of laser drilling, researchers are working to fulfill the requirement of creation of micro holes in advanced ceramics. The present research investigates the laser drilling of 2 mm thick Yttria Stabilized Zirconia with the aim to achieve good micro holes with reduced geometrical inaccuracies and improved hole quality. The results show that multiple quality response comprising hole circularity, hole taper and recast layer thickness has been improved at optimally selected process parameters.

Use of enzymes to minimize the rheological dough problems caused by high levels of damaged starch in starch-gluten systems.

PubMed

Barrera, Gabriela N; León, Alberto E; Ribotta, Pablo D

2016-05-01

During wheat milling, starch granules can experience mechanical damage, producing damaged starch. High levels of damaged starch modify the physicochemical properties of wheat flour, negatively affecting the dough behavior as well as the flour quality and cookie and bread making quality. The aim of this work was to evaluate the effect of α-amylase, maltogenic amylase and amyloglucosidase on dough rheology in order to propose alternatives to reduce the issues related to high levels of damaged starch. The dough with a high level of damaged starch became more viscous and resistant to deformations as well as less elastic and extensible. The soluble fraction of the doughs influenced the rheological behavior of the systems. The α-amylase and amyloglucosidase reduced the negative effects of high damaged starch contents, improving the dough rheological properties modified by damaged starch. The rheological behavior of dough with the higher damaged-starch content was related to a more open gluten network arrangement as a result of the large size of the swollen damaged starch granules. We can conclude that the dough rheological properties of systems with high damaged starch content changed positively as a result of enzyme action, particularly α-amylase and amyloglucosidase additions, allowing the use of these amylases and mixtures of them as corrective additives. Little information was reported about amyloglucosidase activity alone or combined with α-amylase. The combinations of these two enzymes are promising to minimize the negative effects caused by high levels of damaged starch on product quality. More research needs to be done on bread quality combining these two enzymes. © 2015 Society of Chemical Industry. © 2015 Society of Chemical Industry.

Indoor Air Quality and Energy Efficiency

EPA Pesticide Factsheets

EPA completed an extensive modeling study to assess the compatibilities and trade-offs between energy, indoor air quality, and thermal comfort objectives for HVAC systems and to formulate strategies for superior performance across all areas.

Reforestation to enhance Appalachian mined lands as habitat for terrestrial wildlife

USGS Publications Warehouse

Wood, Petra B.; Larkin, Jeff; Mizel, Jeremy; Zipper, Carl E.; Angel, Patrick

2013-01-01

Surface mining is widespread throughout the Appalachian coalfield, a region with extensive forests that are rich in wildlife. Game species for hunting, non-game wildlife species, and other organisms are important contributors to sustainable and productive ecosystems. Although small breaks in the forest canopy are important to wildlife diversity, most native Appalachian wildlife species require primarily forested habitats. This Forest Reclamation Advisory provides guidance on reforestation practices to provide high quality habitat for native forest wildlife on Appalachian coal mines.

An X-protocol based medical teleconsultation system using low or high speed networks. A specific-design approach.

PubMed Central

Dueñas, A.; González, M. A.; Muñoz, A.; Salvador, C. H.

1994-01-01

The objective of this proposal is to provide solutions for the necessities of teleconsultation or telediagnosis among medical professionals, using work stations within the X-Windows environment and applicable in communication lines with an extensive range of bandwidths and operating system independence. Among the advantages sought are savings in transportation, improvement in the quality of the medical attention provided and continued training for the medical professional. Images Fig. 1 PMID:7949963

A decade of aeroacoustic research at NASA Ames Research Center

NASA Technical Reports Server (NTRS)

Schmitz, Frederic H.; Mosher, M.; Kitaplioglu, Cahit; Cross, J.; Chang, I.

1988-01-01

The rotorcraft aeroacoustic research accomplishments of the past decade at Ames Research Center are reviewed. These include an extensive sequence of flight, ground, and wind tunnel tests that have utilized the facilities to guide and pioneer theoretical research. Many of these experiments were of benchmark quality. The experiments were used to isolate the inadequacies of linear theory in high-speed impulsive noise research, have led to the development of theoretical approaches, and have guided the emerging discipline of computational fluid dynamics to rotorcraft aeroacoustic problems.

Towards shared patient records: an architecture for using routine data for nationwide research.

PubMed

Knaup, Petra; Garde, Sebastian; Merzweiler, Angela; Graf, Norbert; Schilling, Freimut; Weber, Ralf; Haux, Reinhold

2006-01-01

Ubiquitous information is currently one of the most challenging slogans in medical informatics research. An adequate architecture for shared electronic patient records is needed which can use data for multiple purposes and which is extensible for new research questions. We introduce eardap as architecture for using routine data for nationwide clinical research in a multihospital environment. eardap can be characterized as terminology-based. Main advantage of our approach is the extensibility by new items and new research questions. Once the definition of items for a research question is finished, a consistent, corresponding database can be created without any informatics skills. Our experiences in pediatric oncology in Germany have shown the applicability of eardap. The functions of our core system were in routine clinical use in several hospitals. We validated the terminology management system (TMS) and the module generation tool with the basic data set of pediatric oncology. The multiple usability depends mainly on the quality of item planning in the TMS. High quality harmonization will lead to a higher amount of multiply used data. When using eardap, special emphasis is to be placed on interfaces to local hospital information systems and data security issues.

Human Ageing Genomic Resources: Integrated databases and tools for the biology and genetics of ageing

PubMed Central

Tacutu, Robi; Craig, Thomas; Budovsky, Arie; Wuttke, Daniel; Lehmann, Gilad; Taranukha, Dmitri; Costa, Joana; Fraifeld, Vadim E.; de Magalhães, João Pedro

2013-01-01

The Human Ageing Genomic Resources (HAGR, http://genomics.senescence.info) is a freely available online collection of research databases and tools for the biology and genetics of ageing. HAGR features now several databases with high-quality manually curated data: (i) GenAge, a database of genes associated with ageing in humans and model organisms; (ii) AnAge, an extensive collection of longevity records and complementary traits for >4000 vertebrate species; and (iii) GenDR, a newly incorporated database, containing both gene mutations that interfere with dietary restriction-mediated lifespan extension and consistent gene expression changes induced by dietary restriction. Since its creation about 10 years ago, major efforts have been undertaken to maintain the quality of data in HAGR, while further continuing to develop, improve and extend it. This article briefly describes the content of HAGR and details the major updates since its previous publications, in terms of both structure and content. The completely redesigned interface, more intuitive and more integrative of HAGR resources, is also presented. Altogether, we hope that through its improvements, the current version of HAGR will continue to provide users with the most comprehensive and accessible resources available today in the field of biogerontology. PMID:23193293

Urban Air Toxics Monitoring Program, 1989

DOE Office of Scientific and Technical Information (OSTI.GOV)

McAllister, R.A.; Moore, W.H.; Rice, J.

1990-10-01

From January 1989 through January 1990 samples of ambient air were collected at 14 sites in the eastern part of the U.S. Every 12 days, air was integrated over 24-hour periods into passivated stainless steel canisters. Simultaneously, air was drawn through cartridges containing dinitrophenylhydrazine to collect carbonyl compounds. The samples were analyzed at a central laboratory for a total of 37 halogenated and aromatic hydrocarbons, formaldehyde, acetaldehyde, and other oxygenated species. The hydrocarbon species were analyzed by gas chromatography/multiple detectors and gas chromatography/mass spectrometry, while the carbonyl species were analyzed by liquid chromatography. An extensive quality assurance program was carriedmore » on to secure high quality data. Complete data for all the carbonyl samples are presented in the report.« less

High quality copy number and genotype data from FFPE samples using Molecular Inversion Probe (MIP) microarrays

PubMed Central

Wang, Yuker; Carlton, Victoria EH; Karlin-Neumann, George; Sapolsky, Ronald; Zhang, Li; Moorhead, Martin; Wang, Zhigang C; Richardson, Andrea L; Warren, Robert; Walther, Axel; Bondy, Melissa; Sahin, Aysegul; Krahe, Ralf; Tuna, Musaffe; Thompson, Patricia A; Spellman, Paul T; Gray, Joe W; Mills, Gordon B; Faham, Malek

2009-01-01

Background A major challenge facing DNA copy number (CN) studies of tumors is that most banked samples with extensive clinical follow-up information are Formalin-Fixed Paraffin Embedded (FFPE). DNA from FFPE samples generally underperforms or suffers high failure rates compared to fresh frozen samples because of DNA degradation and cross-linking during FFPE fixation and processing. As FFPE protocols may vary widely between labs and samples may be stored for decades at room temperature, an ideal FFPE CN technology should work on diverse sample sets. Molecular Inversion Probe (MIP) technology has been applied successfully to obtain high quality CN and genotype data from cell line and frozen tumor DNA. Since the MIP probes require only a small (~40 bp) target binding site, we reasoned they may be well suited to assess degraded FFPE DNA. We assessed CN with a MIP panel of 50,000 markers in 93 FFPE tumor samples from 7 diverse collections. For 38 FFPE samples from three collections we were also able to asses CN in matched fresh frozen tumor tissue. Results Using an input of 37 ng genomic DNA, we generated high quality CN data with MIP technology in 88% of FFPE samples from seven diverse collections. When matched fresh frozen tissue was available, the performance of FFPE DNA was comparable to that of DNA obtained from matched frozen tumor (genotype concordance averaged 99.9%), with only a modest loss in performance in FFPE. Conclusion MIP technology can be used to generate high quality CN and genotype data in FFPE as well as fresh frozen samples. PMID:19228381

30 CFR 14.8 - Quality assurance.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Quality assurance. 14.8 Section 14.8 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR TESTING, EVALUATION, AND APPROVAL OF... Quality assurance. Applicants granted an approval or an extension of approval under this Part must: (a) In...

30 CFR 15.8 - Quality assurance.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Quality assurance. 15.8 Section 15.8 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR TESTING, EVALUATION, AND APPROVAL OF... § 15.8 Quality assurance. (a) Applicants granted an approval or an extension of approval under this...

Quality Improvement Initiative in School-Based Health Centers across New Mexico

ERIC Educational Resources Information Center

Booker, John M.; Schluter, Janette A.; Carrillo, Kris; McGrath, Jane

2011-01-01

Background: Quality improvement principles have been applied extensively to health care organizations, but implementation of quality improvement methods in school-based health centers (SBHCs) remains in a developmental stage with demonstration projects under way in individual states and nationally. Rural areas, such as New Mexico, benefit from the…

Microelectrodes Based investigation of the Impacts of Water Chemistry on Copper and Iron Corrosion

EPA Science Inventory

The effect of bulk drinking water quality on copper and iron pipe corrosion has been extensively studied. Despite past research, many have argued that bulk water quality does not necessarily reflect water quality near the water-metal interface and that such knowledge is necessary...

Journal Quality in Mathematics Education

ERIC Educational Resources Information Center

Williams, Steven R.; Leatham, Keith R.

2017-01-01

We present the results of 2 studies, a citation-based study and an opinion-based study, that ranked the relative quality of 20 English-language journals that exclusively or extensively publish mathematics education research. We further disaggregate the opinion-based data to provide insights into variations in judgment of journal quality based on…

Twenty years of meta-analyses in orthopaedic surgery: has quality kept up with quantity?

PubMed

Dijkman, Bernadette G; Abouali, Jihad A K; Kooistra, Bauke W; Conter, Henry J; Poolman, Rudolf W; Kulkarni, Abhaya V; Tornetta, Paul; Bhandari, Mohit

2010-01-01

As the number of studies in the literature is increasing, orthopaedic surgeons highly depend on meta-analyses as their primary source of scientific evidence. The objectives of this review were to assess the scientific quality and number of published meta-analyses on orthopaedics-related topics over time. We conducted, in duplicate and independently, a systematic review of published meta-analyses in orthopaedics in the years 2005 and 2008 and compared them with a previous systematic review of meta-analyses from 1969 to 1999. A search of electronic databases (MEDLINE, EMBASE, and the Cochrane Database of Systematic Reviews) was performed to identify meta-analyses published in 2005 and 2008. We searched bibliographies and contacted content experts to identify additional relevant studies. Two investigators independently assessed the quality of the studies, using the Oxman and Guyatt index, and abstracted relevant data. We included forty-five and forty-four meta-analyses from 2005 and 2008, respectively. While the number of meta-analyses increased fivefold from 1999 to 2008, the mean quality score did not change significantly over time (p = 0.067). In the later years, a significantly lower proportion of meta-analyses had methodological flaws (56% in 2005 and 68% in 2008) compared with meta-analyses published prior to 2000 (88%) (p = 0.006). In 2005 and 2008, respectively, 18% and 30% of the meta-analyses had major to extensive flaws in their methodology. Studies from 2008 with positive conclusions used and described appropriate criteria for the validity assessment less often than did those with negative results. The use of random-effects and fixed-effects models as pooling methods became more popular toward 2008. Although the methodological quality of orthopaedic meta-analyses has increased in the past twenty years, a substantial proportion continues to show major to extensive flaws. As the number of published meta-analyses is increasing, a routine checklist for scientific quality should be used in the peer-review process to ensure methodological standards for publication.

Meat quality characteristics of Turkish indigenous Hair goat kids reared under traditional extensive production system: effects of slaughter age and gender.

PubMed

Toplu, Hayriye Deger Oral; Goksoy, Ergun Omer; Nazligul, Ahmet; Kahraman, Tolga

2013-08-01

Meat quality characteristics of Turkish indigenous Hair goat kids reared under an extensive production system were investigated in this study. A total of 60 Hair goat kids (30 females and 30 males) were slaughtered at 3, 6, 9, and 12 months of ages. Slaughter age significantly affected meat quality characteristics. Cooking loss (P < 0.01) and shear force value (P < 0.001) increased with age. Meat color became darker red with increasing slaughter age (P < 0.001). The percentage of fat of musculus (M.) semimembranosus increased with age (P < 0.01). The percentage of saturated fatty acids was significantly higher (P < 0.01), whereas the percentage of unsaturated fatty acids was lower (P < 0.001) in the M. longissimus dorsi of the kids slaughtered at 3 months of age than those in the other age groups. The females had higher intramuscular fat than that in males (P < 0.001) and meat from male kids contained a higher percentage of polyunsaturated fatty acid than that from females (P < 0.01). In conclusion, meat from Hair kids slaughtered between 3 and 9 months of ages had better quality than those slaughtered at the other ages and also meat from male kids had better quality than those female kids slaughtered at the same age under extensive production system.

Effect of postharvest ultraviolet-C treatment on the proteome changes in fresh cut mango (Mangifera indica L. cv. Chokanan).

PubMed

George, Dominic Soloman; Razali, Zuliana; Santhirasegaram, Vicknesha; Somasundram, Chandran

2016-06-01

Postharvest treatments of fruits using techniques such as ultraviolet-C have been linked with maintenance of the fruit quality as well as shelf-life extension. However, the effects of this treatment on the quality of fruits on a proteomic level remain unclear. This study was conducted in order to understand the response of mango fruit to postharvest UV-C irradiation. Approximately 380 reproducible spots were detected following two-dimensional gel electrophoresis. Through gel analysis, 24 spots were observed to be differentially expressed in UV-C treated fruits and 20 were successfully identified via LCMS/MS. Postharvest UV-C treatment resulted in degradative effects on these identified proteins of which 40% were related to stress response, 45% to energy and metabolism and 15% to ripening and senescence. In addition, quality and shelf-life analysis of control and irradiated mangoes was evaluated. UV-C was found to be successful in retention of quality and extension of shelf-life up to 15 days. Furthermore, UV-C was also successful in increasing antioxidants (total flavonoid, reducing power and ABTS scavenging activity) in mangoes. This study provides an overview of the effects of UV-C treatment on the quality of mango on a proteomic level as well as the potential of this treatment in shelf-life extension of fresh-cut fruits. © 2015 Society of Chemical Industry. © 2015 Society of Chemical Industry.

Impact of green roofs on stormwater quality in a South Australian urban environment.

PubMed

Razzaghmanesh, M; Beecham, S; Kazemi, F

2014-02-01

Green roofs are an increasingly important component of water sensitive urban design systems and can potentially improve the quality of urban runoff. However, there is evidence that they can occasionally act as a source rather than a sink for pollutants. In this study, the water quality of the outflow from both intensive and extensive green roof systems were studied in the city of Adelaide, South Australia over a period of nine months. The aim was to examine the effects of different green roof configurations on stormwater quality and to compare this with runoff from aluminium and asphalt roofs as control surfaces. The contaminant concentrations in runoff from both intensive and extensive green roofs generally decreased during the study period. A comparison between the two types of green roof showed that except for some events for EC, TDS and chloride, the values of the parameters such as pH, turbidity, nitrate, phosphate and potassium in intensive green roof outflows were higher than in the outflows from the extensive green roofs. These concentrations were compared to local, state, national and international water quality guidelines in order to investigate the potential for outflow runoff from green roofs to be reused for potable and non-potable purposes. The study found that green roof outflow can provide an alternative water source for non-potable purposes such as urban landscape irrigation and toilet flushing. © 2013.

77 FR 13496 - Effective Date for the Water Quality Standards for the State of Florida's Lakes and Flowing Waters

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-07

... Effective Date for the Water Quality Standards for the State of Florida's Lakes and Flowing Waters AGENCY... Protection Agency (EPA) is finalizing an extension of the March 6, 2012 effective date of the ``Water Quality... INFORMATION: I. General Information Does this action apply to me? Citizens concerned with water quality in...

Removing the Tension from Extension

ERIC Educational Resources Information Center

Bradley, Lucy; Driscoll, Elizabeth; Bardon, Robert

2012-01-01

Job burnout and stress begin with day-to-day frustrations, roadblocks, and unmet expectations. These can transform job satisfaction and, ultimately, career choices, affecting the quality of programs, expense to universities, and relationships with the community. A series of innovative statewide workshops involving 97 agents and Extension directors…

Modified dough preparation for Alveograph analysis with limited flour sample size

USDA-ARS?s Scientific Manuscript database

Dough rheological characteristics, such as resistance-to-extension and extensibility, obtained by alveograph testing are important traits for determination of wheat and flour quality. A challenging issue that faces wheat breeding programs and some wheat-research projects is the relatively large flou...

Power Extension Package (PEP) system definition extension, orbital service module systems analysis study. Volume 10: PEP project plan

NASA Technical Reports Server (NTRS)

1979-01-01

Contents: project plan summary; project and mission objectives; related studies and technology support activities; technical summary; management; procurement approach; project definition items and schedule; resources; management review; controlled items; and safety, reliability, and quality assurance.

75 FR 43069 - Approval of One-Year Extension for Attaining the 1997 8-Hour Ozone Standard in the Baltimore...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-23

... standard (NAAQS). This extension is based in part on air quality data for the 4th highest daily 8-hour... attainment date if: (a) For the first one-year extension, the area's 4th highest daily 8-hour average in the... 4th highest daily 8-hour value, averaged over both the original attainment year and the first...

A combined geostatistical-optimization model for the optimal design of a groundwater quality monitoring network

NASA Astrophysics Data System (ADS)

Kolosionis, Konstantinos; Papadopoulou, Maria P.

2017-04-01

Monitoring networks provide essential information for water resources management especially in areas with significant groundwater exploitation due to extensive agricultural activities. In this work, a simulation-optimization framework is developed based on heuristic optimization methodologies and geostatistical modeling approaches to obtain an optimal design for a groundwater quality monitoring network. Groundwater quantity and quality data obtained from 43 existing observation locations at 3 different hydrological periods in Mires basin in Crete, Greece will be used in the proposed framework in terms of Regression Kriging to develop the spatial distribution of nitrates concentration in the aquifer of interest. Based on the existing groundwater quality mapping, the proposed optimization tool will determine a cost-effective observation wells network that contributes significant information to water managers and authorities. The elimination of observation wells that add little or no beneficial information to groundwater level and quality mapping of the area can be obtain using estimations uncertainty and statistical error metrics without effecting the assessment of the groundwater quality. Given the high maintenance cost of groundwater monitoring networks, the proposed tool could used by water regulators in the decision-making process to obtain a efficient network design that is essential.

Examples of subjective image quality enhancement in multimedia

NASA Astrophysics Data System (ADS)

Klíma, Miloš; Pazderák, Jiří; Fliegel, Karel

2007-09-01

The subjective image quality is an important issue in all multimedia imaging systems with a significant impact onto QoS (Quality of Service). For long time the image fidelity criterion was widely applied in technical systems esp. in both television and image source compression fields but the optimization of subjective perception quality and fidelity approach (such as the minimum of MSE) are very different. The paper presents an experimental testing of three different digital techniques for the subjective image quality enhancement - color saturation, edge enhancement, denoising operators and noise addition - well known from both the digital photography and video. The evaluation has been done for extensive operator parameterization and the results are summarized and discussed. It has been demonstrated that there are relevant types of image corrections improving to some extent the subjective perception of the image. The above mentioned techniques have been tested for five image tests with significantly different image characteristics (fine details, large saturated color areas, high color contrast, easy-to-remember colors etc.). The experimental results show the way to optimized use of image enhancing operators. Finally the concept of impressiveness as a new possible expression of subjective quality improvement is presented and discussed.

Sustainability of community-led total sanitation outcomes: Evidence from Ethiopia and Ghana.

PubMed

Crocker, Jonny; Saywell, Darren; Bartram, Jamie

2017-05-01

We conducted a study to evaluate the sustainability of community-led total sanitation (CLTS) outcomes in Ethiopia and Ghana. Plan International, with local actors, implemented four CLTS interventions from 2012 to 2014: health extension worker-facilitated CLTS and teacher-facilitated CLTS in Ethiopia, and NGO-facilitated CLTS with and without training for natural leaders in Ghana. We previously evaluated these interventions using survey data collected immediately after implementation ended, and concluded that in Ethiopia health extension workers were more effective facilitators than teachers, and that in Ghana training natural leaders improved CLTS outcomes. For this study, we resurveyed 3831 households one year after implementation ended, and analyzed latrine use and quality to assess post-intervention changes in sanitation outcomes, to determine if our original conclusions were robust. In one of four interventions evaluated (health extension worker-facilitated CLTS in Ethiopia), there was an 8 percentage point increase in open defecation in the year after implementation ended, challenging our prior conclusion on their effectiveness. For the other three interventions, the initial decreases in open defecation of 8-24 percentage points were sustained, with no significant changes occurring in the year after implementation. On average, latrines in Ethiopia were lower quality than those in Ghana. In the year following implementation, forty-five percent of households in Ethiopia repaired or rebuilt latrines that had become unusable, while only 6% did in Ghana possibly due to higher latrine quality. Across all four interventions and three survey rounds, most latrines remained unimproved. Regardless of the intervention, households in villages higher latrine use were more likely to have sustained latrine use, which together with the high latrine repair rates indicates a potential social norm. There are few studies that revisit villages after an initial evaluation to assess sustainability of sanitation outcomes. This study provides new evidence that CLTS outcomes can be sustained in the presence of training provided to local actors, and strengthens previous recommendations that CLTS is not appropriate in all settings and should be combined with efforts to address barriers households face to building higher quality latrines. Copyright © 2017 The Authors. Published by Elsevier GmbH.. All rights reserved.

Improving coverage of postnatal care in rural Ethiopia using a community-based, collaborative quality improvement approach.

PubMed

Tesfaye, Solomon; Barry, Danika; Gobezayehu, Abebe Gebremariam; Frew, Aynalem Hailemichael; Stover, Kim Ethier; Tessema, Hana; Alamineh, Lamesgin; Sibley, Lynn M

2014-01-01

Ethiopia has high maternal and neonatal mortality and low use of skilled maternity care. The Maternal and Newborn Health in Ethiopia Partnership (MaNHEP), a 3.5-year learning project, used a community collaborative quality improvement approach to improve maternal and newborn health care during the birth-to-48-hour period. This study examines how the promotion of community maternal and newborn health (CMNH) family meetings and labor and birth notification contributed to increased postnatal care within 48 hours by skilled providers or health extension workers. Baseline and endline surveys, monthly quality improvement data, and MaNHEP's CMNH change package, a compendium of the most effective changes developed and tested by communities, were reviewed. Logistic regression assessed factors associated with postnatal care receipt. Monthly postnatal care receipt was plotted with control charts. The baseline (n = 1027) and endline (n = 1019) surveys showed significant increases in postnatal care, from 5% to 51% and from 15% to 47% in the Amhara and Oromiya regions, respectively (both P < .001). Notification of health extension workers for labor and birth within 48 hours was closely linked with receipt of postnatal care. Women with any antenatal care were 1.7 times more likely to have had a postnatal care visit (odds ratio [OR], 1.67; 95% confidence interval [CI], 1.10-2.54; P < .001). Women who had additionally attended 2 or more CMNH meetings with family members and had access to a health extension worker's mobile phone number were 4.9 times more likely to have received postnatal care (OR, 4.86; 95% CI, 2.67-8.86; P < .001). The increase in postnatal care far exceeds the 7% postnatal care coverage rate reported in the 2011 Ethiopian Demographic and Health Survey (EDHS). This result was linked to ideas generated by community quality improvement teams for labor and birth notification and cooperation with community-level health workers to promote antenatal care and CMNH family meetings. © 2014 by the American College of Nurse-Midwives.

The bioimpedance phase angle predicts low muscle strength, impaired quality of life, and increased mortality in old patients with cancer.

PubMed

Norman, Kristina; Wirth, Rainer; Neubauer, Maxi; Eckardt, Rahel; Stobäus, Nicole

2015-02-01

We investigated the impact of low phase angle (PhA) values on muscle strength, quality of life, symptom severity, and 1-year mortality in older cancer patients. Prospective study with 1-year follow-up. Cancer patients aged >60 years. PhA was derived from whole body impedance analysis. The fifth percentile of age-, sex-, and body mass index-stratified reference values were used as cut-off. Quality of life was determined with the European Organization of Research and Treatment in Cancer questionnaire, reflecting both several function scales and symptom severity. Muscle strength was assessed by hand grip strength, knee extension strength, and peak expiratory flow. 433 cancer patients, aged 60-95 years, were recruited. Patients with low PhA (n = 197) exhibited decreased muscle strength compared with patients with normal PhA (hand grip strength: 22 ± 8.6 vs 28.9 ± 8.9 kg, knee extension strength: 20.8 ± 11.8 vs 28.1 ± 14.9 kg, and peak expiratory flow: 301.1 ± 118 vs 401.7 ± 142.6 L/min, P < .001). Physical function, global health status, and role function from the European Organization of Research and Treatment in Cancer questionnaire were reduced, and most symptoms (fatigue, anorexia, pain, and dyspnea) increased in patients with low PhA (P < .001). In a risk-factor adjusted regression analysis, PhA emerged as independent predictor of physical function (ß:-0.538, P = .023), hand grip strength (ß:-4.684, P < .0001), knee extension strength (ß:-4.548, P = .035), and peak expiratory flow (ß:-66.836, P < .0001). Low PhA moreover predicted 1-year mortality in the Cox proportional hazards regression model, whereas grip strength was no longer significant. PhA below the fifth reference percentile is highly predictive of decreased muscle strength, impaired quality of life, and increased mortality in old patients with cancer and should be evaluated in routine assessment. Copyright © 2015 AMDA – The Society for Post-Acute and Long-Term Care Medicine. Published by Elsevier Inc. All rights reserved.

[The hybrid operating room. Home of high-end intraoperative imaging].

PubMed

Gebhard, F; Riepl, C; Richter, P; Liebold, A; Gorki, H; Wirtz, R; König, R; Wilde, F; Schramm, A; Kraus, M

2012-02-01

A hybrid operating room must serve the medical needs of different highly specialized disciplines. It integrates interventional techniques for cardiovascular procedures and allows operations in the field of orthopaedic surgery, neurosurgery and maxillofacial surgery. The integration of all steps such as planning, documentation and the procedure itself saves time and precious resources. The best available imaging devices and user interfaces reduce the need for extensive personnel in the OR and facilitate new minimally invasive procedures. The immediate possibility of postoperative control images in CT-like quality enables the surgeon to react to problems during the same procedure without the need for later revision.

Impact compaction of a granular material

DOE PAGES

Fenton, Gregg; Asay, Blaine; Dalton, Devon

2015-05-19

The dynamic behavior of granular materials has importance to a variety of engineering applications. Structural seismic coupling, planetary science, and earth penetration mechanics, are just a few of the application areas. Although the mechanical behavior of granular materials of various types have been studied extensively for several decades, the dynamic behavior of such materials remains poorly understood. High-quality experimental data are needed to improve our general understanding of granular material compaction physics. This study will describe how an instrumented plunger impact system can be used to measure pressure-density relationships for model materials at high and controlled strain rates and subsequentlymore » used for computational modeling.« less

[Hyperopic Laser-in-situ-Keratomileusis after trifocal intraocular lens implantation : Aberration-free femto-Laser-in-situ-Keratomileusis treatment after implantation of a diffractive, multifocal, toric intraocular lens-case analysis].

PubMed

Hemkeppler, E; Böhm, M; Kohnen, T

2018-05-29

A 52-year-old highly myopic female patient was implanted with a multifocal, diffractive, toric intraocular lens because of the wish to be independent of eyeglasses. Despite high-quality, extensive preoperative examinations, a hyperopic refractive error remained postoperatively, which led to the patient's dissatisfaction. This error was treated with Laser-in-situ-Keratomileusis (LASIK). After corneal LASIK treatment and implantation of a diffractive toric multifocal intraocular lens the patient showed a good postoperative visual result without optical phenomena.

Female qualities in males: vitellogenin synthesis induced by ovary transplants into the male silkworm, Bombyx mori.

PubMed

Yang, Congwen; Lin, Ying; Shen, Guanwang; Chen, Enxiang; Wang, Yanxia; Luo, Juan; Zhang, Haiyan; Xing, Runmiao; Xia, Qingyou

2014-10-10

Female qualities in males are common in vertebrates but have not been extensively reported in insects. Vitellogenin (Vg) is highly expressed in the female fat body and is generally required for the formation of yolk proteins in the insect egg. Vg upregulation is generally regarded as a female quality in female oviparous animals. In this study, we found that Bombyx mori Vg (BmVg) is especially highly expressed in the female pupa. Downregulation of the BmVg gene in the female pupa by RNA interference (RNAi) interfered with egg formation and embryonic development, showing the importance of BmVg in these processes. So, we used BmVg as a biomarker for female qualities in the silkworm. Hematoxylin-eosin staining and immunofluorescence histochemistry showed that ovary transplants induced BmVg synthesis in the male pupa fat body. Ovaries transplanted into male silkworms produced only a few eggs with deformed yolk granules. These results suggested that the amount of BmVg in the male silkworm was insufficient for eggs to undergo complete embryonic development. After 17-beta-estradiol was used to treat male pupae and male pupal fat bodies, BmVg was upregulated in vivo and in vitro. These findings indicated that the male silkworm has innate female qualities that were induced by a transplanted ovary and 17β-estradiol. However, in silkworms, female qualities in males are not as complete as in females. Copyright © 2014 Elsevier Inc. All rights reserved.

Extension of quality-by-design concept to the early development phase of pharmaceutical R&D processes.

PubMed

Csóka, Ildikó; Pallagi, Edina; Paál, Tamás L

2018-03-27

Here, we propose the extension of the quality-by-design (QbD) concept to also fit the early development phases of pharmaceuticals by adding elements that are currently widely applied, but not yet included in the QbD model in a structured way. These are the introduction of a 'zero' preformulation phase (i.e., selection of drug substance, possible dosage forms and administration routes based on the evaluated therapeutic need); building in stakeholders' (industry, patient, and regulatory) requirements into the quality target product profile (QTTP); and the use of modern quality management tools during the composition and process design phase [collecting critical quality attributes (CQAs) and selection of CPPs) for (still laboratory-scale) design space (DS) development. Moreover, during industrial scale-up, CQAs (as well as critical process parameters; CPPs) can be changed; however, we recommend that the existing QbD elements are reconsidered and updated after this phase. Copyright © 2018 Elsevier Ltd. All rights reserved.

Water-based oligochitosan and nanowhisker chitosan as potential food preservatives for shelf-life extension of minced pork.

PubMed

Chantarasataporn, Patomporn; Tepkasikul, Preenapha; Kingcha, Yutthana; Yoksan, Rangrong; Pichyangkura, Rath; Visessanguan, Wonnop; Chirachanchai, Suwabun

2014-09-15

Water-based chitosans in the forms of oligochitosan (OligoCS) and nanowhisker chitosan (CSWK) are proposed as a novel food preservative based on a minced pork model study. The high surface area with a positive charge over the neutral pH range (pH 5-8) of OligoCS and CSWK lead to an inhibition against Gram-positive (Staphylococcus aureus, Listeria monocytogenes, and Bacillus cereus) and Gram-negative microbes (Salmonella enteritidis and Escherichia coli O157:H7). In the minced pork model, OligoCS effectively performs a food preservative for shelf-life extension as clarified from the retardation of microbial growth, biogenic amine formation and lipid oxidation during the storage. OligoCS maintains almost all myosin heavy chain protein degradation as observed in the electrophoresis. The present work points out that water-based chitosan with its unique morphology not only significantly inhibits antimicrobial activity but also maintains the meat quality with an extension of shelf-life, and thus has the potential to be used as a food preservative. Copyright © 2014 Elsevier Ltd. All rights reserved.

An Informatics Blueprint for Healthcare Quality Information Systems

PubMed Central

Niland, Joyce C.; Rouse, Layla; Stahl, Douglas C.

2006-01-01

There is a critical gap in our nation's ability to accurately measure and manage the quality of medical care. A robust healthcare quality information system (HQIS) has the potential to address this deficiency through the capture, codification, and analysis of information about patient treatments and related outcomes. Because non-technical issues often present the greatest challenges, this paper provides an overview of these socio-technical issues in building a successful HQIS, including the human, organizational, and knowledge management (KM) perspectives. Through an extensive literature review and direct experience in building a practical HQIS (the National Comprehensive Cancer Network Outcomes Research Database system), we have formulated an “informatics blueprint” to guide the development of such systems. While the blueprint was developed to facilitate healthcare quality information collection, management, analysis, and reporting, the concepts and advice provided may be extensible to the development of other types of clinical research information systems. PMID:16622161

75 FR 5040 - Extension of Period for Comments on Enhancement in the Quality of Patents

Federal Register 2010, 2011, 2012, 2013, 2014

2010-02-01

... patents, to identify appropriate indicia of quality, and to establish metrics for the measurement of the... issued patents, to identify appropriate indicia of quality, and to establish metrics for the measurement.... Kappos, Under Secretary of Commerce for Intellectual Property and Director of the United States Patent...

Minnesota 4-H Youth Program Quality Improvement Model

ERIC Educational Resources Information Center

Herman, Margo; Grant, Samantha

2015-01-01

The University of Minnesota Extension Center for Youth Development made an organizational decision in 2011 to invest in a system-wide approach to implement youth program quality into the 4-H program using the Youth Program Quality Assessment (YPQA) tool. This article describes the four key components to the Minnesota Youth Program Quality…

Sex-specific relationships of physical activity, body composition, and muscle quality with lower-extremity physical function in older men and women.

PubMed

Straight, Chad R; Brady, Anne O; Evans, Ellen

2015-03-01

This study aims to determine the sex-specific relationships of physical activity, body composition, and muscle quality with lower-extremity physical function in older men and women. Seventy-nine community-dwelling men (n = 39; mean [SD] age, 76.1 [6.2] y; mean [SD] body mass index, 27.3 [3.8] kg/m(2)) and women (n = 40; mean [SD] age, 75.8 [5.5] y; mean [SD] body mass index, 27.0 [3.8] kg/m(2)) were assessed for physical activity via questionnaire, body composition via dual-energy x-ray absorptiometry scanning, leg extension power using the Nottingham power rig, and muscle quality (W/kg; the ratio of leg extension power [W] to lower-body mineral-free lean mass [kg]). A composite measure of physical function was obtained by summing Z scores from the 6-minute walk, 8-ft up-and-go test, and 30-second chair-stand test. As expected, men had significantly greater levels of physical activity, lower adiposity, greater lean mass, higher leg extension power, and greater muscle quality compared with women (all P < 0.05). In linear regression analyses, muscle quality and physical activity were the strongest predictors of lower-extremity physical function in men and independently explained 42% and 29% of the variance, respectively. In women, muscle quality (16%) and percent body fat (12%) were independent predictors after adjustment for covariates. Muscle quality is the strongest predictor of lower-extremity physical function in men and women, but sex impacts the importance of physical activity and adiposity. These findings suggest that older men and women may benefit from different intervention strategies for preventing physical disability and also highlight the importance of weight management for older women to preserve physical function.

The magnitude of variability produced by methods used to estimate annual stormwater contaminant loads for highly urbanised catchments.

PubMed

Beck, H J; Birch, G F

2013-06-01

Stormwater contaminant loading estimates using event mean concentration (EMC), rainfall/runoff relationship calculations and computer modelling (Model of Urban Stormwater Infrastructure Conceptualisation--MUSIC) demonstrated high variability in common methods of water quality assessment. Predictions of metal, nutrient and total suspended solid loadings for three highly urbanised catchments in Sydney estuary, Australia, varied greatly within and amongst methods tested. EMC and rainfall/runoff relationship calculations produced similar estimates (within 1 SD) in a statistically significant number of trials; however, considerable variability within estimates (∼50 and ∼25 % relative standard deviation, respectively) questions the reliability of these methods. Likewise, upper and lower default inputs in a commonly used loading model (MUSIC) produced an extensive range of loading estimates (3.8-8.3 times above and 2.6-4.1 times below typical default inputs, respectively). Default and calibrated MUSIC simulations produced loading estimates that agreed with EMC and rainfall/runoff calculations in some trials (4-10 from 18); however, they were not frequent enough to statistically infer that these methods produced the same results. Great variance within and amongst mean annual loads estimated by common methods of water quality assessment has important ramifications for water quality managers requiring accurate estimates of the quantities and nature of contaminants requiring treatment.

Effect of barley flour on rheological characteristics of dough, organoleptic, nutritional and storage characteristics of south Indian parotta.

PubMed

Maiya, G Koushika; Shwetha, B G; Indrani, D

2015-01-01

Barley (Hordeum sativum) is a good source of dietary fibre, particularly β-glucan. Effect of 10, 20, 30 and 40% barley flour on the rheological characteristics of dough and quality characteristics of south Indian parotta was studied. Use of increasing amount of barley flour from 0 to 40% increased farinograph water absorption and decreased stability, increased extensograph resistance to extension and decreased extensibility, decreased amylograph set back and increased peak viscosity values. Sensory analysis showed that use of barley flour above 30% brought about adverse effect on the quality of parotta. Addition of combination of 2% dry gluten powder and 0.001% xylanase enzyme, XY (combination of improvers) decreased elasticity, increased extensibility of the dough and quality of parotta with 30% BF. During 48 h of storage, parottas with 30% barley flour remained softer than control parotta. The total dietary fibre and β-glucan contents of parotta with 30% BF were 2.0 and 10.5 times higher than the control parotta. © The Author(s) 2013 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.

[Influence of the substrate composition in extensive green roof on the effluent quality].

PubMed

Chen, Yu-Lin; Li, Tian; Gu, Jun-Qing

2014-11-01

By monitoring the effluent quality from different green roof assemblies during several artificial rain events, the main pollutant characteristics and the influence of substrate composition in extensive green roof on the effluent quality were studied. Results showed that the main pollutants in the effluent were N, P and COD; with the increase of cumulative rain, the concentrations of pollutants in the effluent decreased, which had obvious leaching effect; The average concentrations of heavy metals in the early effluent from all assemblies reached drinking water standard, including the assemblies using crushed bricks; When garden soil and compost were used as organic matter, the assemblies had serious leaching of nutrient substance. After the accumulated rainfall reached 150 mm, the TN, TP and COD concentrations of effluent were 2.93, 0.73 and 78 mg x L(-1), respectively, which exceeded the Surface water V class limit. By means of application of the Water Treatment Residual, the leaching of TP from green planting soil was decreased by about 60%. The inorganic compound soil had better effluent quality, however we also need to judge whether the substrate could be applied in extensive green roof or not, by analyzing its ability of water quantity reduction and the plant growth situation.

Using Soil and Water Conservation Contests for Extension: Experiences from the Bolivian Mountain Valleys

PubMed Central

de Graaff, Jan

2007-01-01

Soil and water conservation (SWC) contests among farmer groups were organized in five rural villages in the Bolivian mountain valleys. The contests were aimed at quickly achieving widespread sustainable results. This article analyzes the effectiveness of these contests as an extension tool. Mixed results were obtained. In three villages, participation rates in the SWC activities introduced in the contests were still high even 2 years after project withdrawal. These were all villages where a solid foundation for sustainable development had been laid before the contests were held. Two years later, most families were still involved in maintenance of the SWC practices introduced in the contests, and many farmers had started to experiment with different soil management practices. However, replications of these SWC practices were not widespread, Conservation Leaders did not continue with their training activities, and the quality of maintenance of the practices was often not satisfactory. In order to become a more effective extension tool and achieve widespread impact, SWC contests must receive continued support by a catalyst agency. Moreover, other SWC contests should also be organized in which practices are not predefined. Given that SWC contests are a low-budget extension tool, local municipalities could become more actively involved. PMID:17846829

The influence of Glu-1 and Glu-3 loci on dough rheology and bread-making properties in wheat (Triticum aestivum L.) doubled haploid lines.

PubMed

Langner, Monika; Krystkowiak, Karolina; Salmanowicz, Bolesław P; Adamski, Tadeusz; Krajewski, Paweł; Kaczmarek, Zygmunt; Surma, Maria

2017-12-01

The major determinants of wheat quality are Glu-1 and Glu-3 glutenin loci and environmental factors. Additive effects of alleles at the Glu-1 and Glu-3 loci, as well as their interactions, were evaluated for dough rheology and baking properties in four groups of wheat doubled haploid lines differing in high- and low-molecular-weight glutenin composition. Flour quality, Reomixer (Reologica Instruments, Lund, Sweden), dough extension, Farinograph (Brabender GmbH, Duisburg, Germany) and baking parameters were determined. Groups of lines with the alleles Glu-A3b and Glu-B3d were characterized by higher values of dough and baking parameters compared to those with the Glu-A3e and Glu-B3a alleles. Effects of interactions between allelic variants at the Glu-1 and Glu-3 loci on Reomixer parameters, dough extension tests and baking parameters were significant, although additive effects of individual alleles were not always significant. The allelic variants at Glu-B3 had a much greater effect on dough rheological parameters than the variants at Glu-A3 or Glu-D3 loci. The effect of allelic variations at the Glu-D3 loci on rheological parameters and bread-making quality was non-significant, whereas their interactions with a majority of alleles at the other Glu-1 × Glu-3 loci were significant. © 2017 Society of Chemical Industry. © 2017 Society of Chemical Industry.

Industrial defect discrimination applying infrared imaging spectroscopy and artificial neural networks

NASA Astrophysics Data System (ADS)

Garcia-Allende, Pilar Beatriz; Conde, Olga M.; Madruga, Francisco J.; Cubillas, Ana M.; Lopez-Higuera, Jose M.

2008-03-01

A non-intrusive infrared sensor for the detection of spurious elements in an industrial raw material chain has been developed. The system is an extension to the whole near infrared range of the spectrum of a previously designed system based on the Vis-NIR range (400 - 1000 nm). It incorporates a hyperspectral imaging spectrograph able to register simultaneously the NIR reflected spectrum of the material under study along all the points of an image line. The working material has been different tobacco leaf blends mixed with typical spurious elements of this field such as plastics, cardboards, etc. Spurious elements are discriminated automatically by an artificial neural network able to perform the classification with a high degree of accuracy. Due to the high amount of information involved in the process, Principal Component Analysis is first applied to perform data redundancy removal. By means of the extension to the whole NIR range of the spectrum, from 1000 to 2400 nm, the characterization of the material under test is highly improved. The developed technique could be applied to the classification and discrimination of other materials, and, as a consequence of its non-contact operation it is particularly suitable for food quality control.

Geophysical Studies Based on Gravity and Seismic Data of Tule Desert, Meadow Valley Wash, and California Wash Basins, Southern Nevada

USGS Publications Warehouse

Scheirer, Daniel S.; Page, William R.; Miller, John J.

2006-01-01

Gravity and seismic data from Tule Desert, Meadow Valley Wash, and California Wash, Nevada, provide insight into the subsurface geometry of these three basins that lie adjacent to rapidly developing areas of Clark County, Nevada. Each of the basins is the product of Tertiary extension accommodated with the general form of north-south oriented, asymmetrically-faulted half-grabens. Geophysical inversion of gravity observations indicates that Tule Desert and Meadow Valley Wash basins are segmented into subbasins by shallow, buried basement highs. In this study, basement refers to pre-Cenozoic bedrock units that underlie basins filled with Cenozoic sedimentary and volcanic units. In Tule Desert, a small, buried basement high inferred from gravity data appears to be a horst whose placement is consistent with seismic reflection and magnetotelluric observations. Meadow Valley Wash consists of three subbasins separated by basement highs at structural zones that accommodated different styles of extension of the adjacent subbasins, an interpretation consistent with geologic mapping of fault traces oblique to the predominant north-south fault orientation of Tertiary extension in this area. California Wash is a single structural basin. The three seismic reflection lines analyzed in this study image the sedimentary basin fill, and they allow identification of faults that offset basin deposits and underlying basement. The degree of faulting and folding of the basin-fill deposits increases with depth. Pre-Cenozoic units are observed in some of the seismic reflection lines, but their reflections are generally of poor quality or are absent. Factors that degrade seismic reflector quality in this area are rough land topography due to erosion, deformed sedimentary units at the land surface, rock layers that dip out of the plane of the seismic profile, and the presence of volcanic units that obscure underlying reflectors. Geophysical methods illustrate that basin geometry is more complicated than would be inferred from extrapolation of surface topography and geology, and these methods aid in defining a three-dimensional framework to understand groundwater storage and flow in southern Nevada.

A study on real-time low-quality content detection on Twitter from the users' perspective.

PubMed

Chen, Weiling; Yeo, Chai Kiat; Lau, Chiew Tong; Lee, Bu Sung

2017-01-01

Detection techniques of malicious content such as spam and phishing on Online Social Networks (OSN) are common with little attention paid to other types of low-quality content which actually impacts users' content browsing experience most. The aim of our work is to detect low-quality content from the users' perspective in real time. To define low-quality content comprehensibly, Expectation Maximization (EM) algorithm is first used to coarsely classify low-quality tweets into four categories. Based on this preliminary study, a survey is carefully designed to gather users' opinions on different categories of low-quality content. Both direct and indirect features including newly proposed features are identified to characterize all types of low-quality content. We then further combine word level analysis with the identified features and build a keyword blacklist dictionary to improve the detection performance. We manually label an extensive Twitter dataset of 100,000 tweets and perform low-quality content detection in real time based on the characterized significant features and word level analysis. The results of our research show that our method has a high accuracy of 0.9711 and a good F1 of 0.8379 based on a random forest classifier with real time performance in the detection of low-quality content in tweets. Our work therefore achieves a positive impact in improving user experience in browsing social media content.

Long Term Trend Analysis and Assessment of Water Quality in the Penchala River, Malaysia

NASA Astrophysics Data System (ADS)

Chow, M. F.; Haris, H. B.; Mohd Sidek, L. B.

2014-12-01

Rapid urban expansion produces negative impacts on the natural environment, especially river water quality. Studies assessing long term changes of water quality have been recognized as a key tool for understanding ongoing processes in watersheds and for providing an essential background for evaluation of rapid changes within industrialized and populated urban areas. Unfortunately, only limited studies are available for developing countries such as Malaysia. Thus, a long term study was conducted to evaluate water quality trends at Pencala river basin that has undergone extensive land use changes related to industrial, agricultural and urban activities. Fifteen physical and chemical variables were analysed in river water samples collected every month over a period of 13 years, between 1997 and 2009. The trend study was performed using the Mann-Kendall Seasonal test and the Sen's Slope estimator. Results revealed that most water quality parameters showed a downward trend for yearly average concentration. The water quality index (WQI) for Pencala River was improved from Class V to Class IV, according to National Water Quality Standards for Malaysia. BOD, COD, NH3-N and SS show trends toward decreasing concentrations over time. The improvements seen in water quality appear to be the result of improved wastewater treatment and other water quality improvement efforts achieved through government initiative. Continued long-term and high frequency monitoring is necessary to establish plans and policies for effective water resources management.

A study on real-time low-quality content detection on Twitter from the users’ perspective

PubMed Central

Yeo, Chai Kiat; Lau, Chiew Tong; Lee, Bu Sung

2017-01-01

Detection techniques of malicious content such as spam and phishing on Online Social Networks (OSN) are common with little attention paid to other types of low-quality content which actually impacts users’ content browsing experience most. The aim of our work is to detect low-quality content from the users’ perspective in real time. To define low-quality content comprehensibly, Expectation Maximization (EM) algorithm is first used to coarsely classify low-quality tweets into four categories. Based on this preliminary study, a survey is carefully designed to gather users’ opinions on different categories of low-quality content. Both direct and indirect features including newly proposed features are identified to characterize all types of low-quality content. We then further combine word level analysis with the identified features and build a keyword blacklist dictionary to improve the detection performance. We manually label an extensive Twitter dataset of 100,000 tweets and perform low-quality content detection in real time based on the characterized significant features and word level analysis. The results of our research show that our method has a high accuracy of 0.9711 and a good F1 of 0.8379 based on a random forest classifier with real time performance in the detection of low-quality content in tweets. Our work therefore achieves a positive impact in improving user experience in browsing social media content. PMID:28793347

75 FR 49936 - Notice of Request for Public Comment

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-16

... civil rights clearances, should be granted equal access to quality health care, regardless of race... within 60-days. Proposed Project: The Civil Rights Information Request Form--OMB No. 0990-0243- Extension-Office for Civil Rights. Abstract: The Office of Civil Rights is requesting a 3 year extension of the...

78 FR 17633 - Notice of Request for Extension of a Currently Approved Information Collection

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-22

... DEPARTMENT OF AGRICULTURE Rural Housing Service Notice of Request for Extension of a Currently... Support Staff, Housing and Community Facilities Programs, U.S. Department of Agriculture, Stop 0761, 1400... on the quality of the human environment during agency planning and decision-making processes. For...

Strategic Opportunities for Cooperative Extension

ERIC Educational Resources Information Center

National Association of State Universities and Land-Grant Colleges, 2007

2007-01-01

In this new century, opportunities exist to help advance America's greatness in the midst of many challenges. Energy, water, food, environment, health, economic productivity, global competitiveness, and the quality of the living environments are all paramount to the future. Extension is, as a part of higher education, prepared to create new…

Strategic Opportunities for Cooperative Extension. Executive Summary

ERIC Educational Resources Information Center

National Association of State Universities and Land-Grant Colleges, 2007

2007-01-01

In this new century, opportunities exist to help advance America's greatness in the midst of many challenges. Energy, water, food, environment, health, economic productivity, global competitiveness, and the quality of the living environments are all paramount to the future. Extension is, as a part of higher education, prepared to create new…

LaTeX for Agricultural Extension Professionals

USDA-ARS?s Scientific Manuscript database

LaTeX is a free open source document preparation system for professional quality documents and presentation materials. Extension professionals, trying to reach their audience though various forms of printed and online resources, can benefit from the vast potential of LaTeX. Using LaTeX empowers the ...

77 FR 50692 - Request for Information on Quality Measurement Enabled by Health IT-Extension Date for Responses

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-22

... what types of quality measures should a combination of natural language processing and structured data... collection, analysis, processing, and its ability to facilitate information exchange among and across care...

7 CFR 3401.17 - Review criteria.

Code of Federal Regulations, 2010 CFR

2010-01-01

... Regulations of the Department of Agriculture (Continued) COOPERATIVE STATE RESEARCH, EDUCATION, AND EXTENSION.... Overall scientific and technical quality of proposal 10 2. Scientific and technical quality of the.... Feasibility of attaining objectives; adequacy of professional training and experience, facilities and...

#2) Sensor Technology-State of the Science

EPA Science Inventory

Establish market surveys of commercially-available air quality sensorsConduct an extensive literature survey describing the state of sensor technologiesInvestigate emerging technologies and their potential to meet future air quality monitoring needs for the Agency as well as othe...

Reduction in respiratory motion artefacts on gadoxetate-enhanced MRI after training technicians to apply a simple and more patient-adapted breathing command.

PubMed

Gutzeit, Andreas; Matoori, Simon; Froehlich, Johannes M; von Weymarn, Constantin; Reischauer, Carolin; Kolokythas, Orpheus; Goyen, Matthias; Hergan, Klaus; Meissnitzer, Matthias; Forstner, Rosemarie; Soyka, Jan D; Doert, Aleksis; Koh, Dow-Mu

2016-08-01

To investigate whether a trained group of technicians using a modified breathing command during gadoxetate-enhanced liver MRI reduces respiratory motion artefacts compared to non-trained technicians using a traditional breathing command. The gadoxetate-enhanced liver MR images of 30 patients acquired using the traditional breathing command and the subsequent 30 patients after training the technicians to use a modified breathing command were analyzed. A subgroup of patients (n = 8) underwent scans both by trained and untrained technicians. Images obtained using the traditional and modified breathing command were compared for the presence of breathing artefacts [respiratory artefact-based image quality scores from 1 (best) to 5 (non-diagnostic)]. There was a highly significant improvement in the arterial phase image quality scores in patients using the modified breathing command compared to the traditional one (P < 0.001). The percentage of patients with severe and extensive breathing artefacts in the arterial phase decreased from 33.3 % to 6.7 % after introducing the modified breathing command (P = 0.021). In the subgroup that underwent MRI using both breathing commands, arterial phase image quality improved significantly (P = 0.008) using the modified breathing command. Training technicians to use a modified breathing command significantly improved arterial phase image quality of gadoxetate-enhanced liver MRI. • A modified breathing command reduced respiratory artefacts on arterial-phase gadoxetate-enhanced MRI (P < 0.001). • The modified command decreased severe and extensive arterial-phase breathing artefacts (P = 0.021). • Training technicians to use a modified breathing command improved arterial-phase images.

Meat quality of "Galician Mountain" foals breed. Effect of sex, slaughter age and livestock production system.

PubMed

Franco, Daniel; Rodríguez, Eva; Purriños, Laura; Crecente, Santiago; Bermúdez, Roberto; Lorenzo, José M

2011-06-01

The effects of sex, slaughter age (9 vs. 12 months) and livestock production system (freedom extensive system (FES) vs. semi extensive system (SES)) of "Galician Mountain" foals breed on meat quality from the Longissimus dorsi (LD) muscle were investigated. Forty-two foals had been used for this study, 19 (11 females and 8 males) were reared in a semi extensive system and weaned three months prior to slaughtering (8 and 11 were slaughtered at 9 and 12 months, respectively) while the other 23 (11 females and 12 males) were reared together with its mothers in a system in freedom and were slaughtered at the age of 9 months. The obtained results showed that there were no significant differences between the sexes and the slaughter age whereas the livestock production system was a significant variation source on intramuscular fat content and meat tenderness because SES foals showed 51.6% more of IMF and the improved meat tenderness achieved a shear force of <3 kg. In general, the meat from foals of the study at hand showed very lean meat (<0.3% in IMF) with a high protein content (>20.5%) and heme-iron (1.62 mg/100g meat) comparable to veal meat. Furthermore, the meat samples showed a higher luminosity (L*>40), a very good water holding capacity, measured by cooking losses (<18.3%), and a tenderness less than 4 kg. Thus, it can be classified as "very tender" meat. Copyright © 2011 Elsevier Ltd. All rights reserved.

Nonmethane organic compound monitoring program. Final report 1988. Volume 2. Urban air toxics monitoring program

DOE Office of Scientific and Technical Information (OSTI.GOV)

McAllister, R.A.; Moore, W.H.; Rice, J.

1989-04-01

From October, 1987 to October, 1988 samples of ambient air were collected at 19 sites in the eastern part of the U.S. Every 12 days, air was integrated over 24-hour periods into passivated stainless steel canisters. Simultaneously, air was drawn through cartridges containing dinitrophenylhydrazine to collect carbonyl compounds. The samples were analyzed at a central laboratory for a total of 37 halogenated and aromatic hydrocarbons, formaldehyde, acetaldehyde, and other oxygenated species. The hydrocarbon species were analyzed by gas chromatography/multiple detectors and gas chromatography/mass spectrometry, while the carbonyl species were analyzed by liquid chromatography. An extensive quality assurance program was carriedmore » on to secure high quality data. Complete data for all the hydrocarbon samples are presented in the report.« less

ACOEM practice guidelines: elbow disorders.

PubMed

Hegmann, Kurt T; Hoffman, Harold E; Belcourt, Roger M; Byrne, Kevin; Glass, Lee; Melhorn, J Mark; Richman, Jack; Zinni, Phillip; Thiese, Matthew S; Ott, Ulrike; Tokita, Kylee; Passey, Deborah Gwenevere; Effiong, Atim Cecelia; Robbins, Riann Bree; Ording, Julie A

2013-11-01

The American College of Occupational and Environmental Medicine has updated the treatment guidelines in its Elbow Disorders chapter through revision processes begun in 2006. This abbreviated version of that chapter highlights some of the evidence and recommendations developed. Comprehensive systematic literature reviews were accomplished with article abstraction, critiquing, grading, evidence table compilation, and guideline finalization by a multidisciplinary expert panel and extensive peer-review to develop evidence-based guidance. Consensus recommendations were formulated when evidence was lacking and often relied on analogy to other disorders for which evidence exists. A total of 108 high- or moderate-quality trials were identified for elbow disorders. Guidance has been developed for 13 major diagnoses and includes 270 specific recommendations. Quality evidence is now available to guide treatment for elbow disorders, particularly for lateral epicondylalgia.

Pippi — Painless parsing, post-processing and plotting of posterior and likelihood samples

NASA Astrophysics Data System (ADS)

Scott, Pat

2012-11-01

Interpreting samples from likelihood or posterior probability density functions is rarely as straightforward as it seems it should be. Producing publication-quality graphics of these distributions is often similarly painful. In this short note I describe pippi, a simple, publicly available package for parsing and post-processing such samples, as well as generating high-quality PDF graphics of the results. Pippi is easily and extensively configurable and customisable, both in its options for parsing and post-processing samples, and in the visual aspects of the figures it produces. I illustrate some of these using an existing supersymmetric global fit, performed in the context of a gamma-ray search for dark matter. Pippi can be downloaded and followed at http://github.com/patscott/pippi.

Soft bilateral filtering volumetric shadows using cube shadow maps

PubMed Central

Ali, Hatam H.; Sunar, Mohd Shahrizal; Kolivand, Hoshang

2017-01-01

Volumetric shadows often increase the realism of rendered scenes in computer graphics. Typical volumetric shadows techniques do not provide a smooth transition effect in real-time with conservation on crispness of boundaries. This research presents a new technique for generating high quality volumetric shadows by sampling and interpolation. Contrary to conventional ray marching method, which requires extensive time, this proposed technique adopts downsampling in calculating ray marching. Furthermore, light scattering is computed in High Dynamic Range buffer to generate tone mapping. The bilateral interpolation is used along a view rays to smooth transition of volumetric shadows with respect to preserving-edges. In addition, this technique applied a cube shadow map to create multiple shadows. The contribution of this technique isreducing the number of sample points in evaluating light scattering and then introducing bilateral interpolation to improve volumetric shadows. This contribution is done by removing the inherent deficiencies significantly in shadow maps. This technique allows obtaining soft marvelous volumetric shadows, having a good performance and high quality, which show its potential for interactive applications. PMID:28632740

Size–strain separation in diffraction line profile analysis

DOE Office of Scientific and Technical Information (OSTI.GOV)

Scardi, P.; Ermrich, M.; Fitch, A.

Separation of size and strain effects on diffraction line profiles has been studied in a round robin involving laboratory instruments and synchrotron radiation beamlines operating with different radiation, optics, detectors and experimental configurations. The studied sample, an extensively ball milled iron alloy powder, provides an ideal test case, as domain size broadening and strain broadening are of comparable size. The high energy available at some synchrotron radiation beamlines provides the best conditions for an accurate analysis of the line profiles, as the size–strain separation clearly benefits from a large number of Bragg peaks in the pattern; high counts, reliable intensitymore » values in low-absorption conditions, smooth background and data collection at different temperatures also support the possibility to include diffuse scattering in the analysis, for the most reliable assessment of the line broadening effect. However, results of the round robin show that good quality information on domain size distribution and microstrain can also be obtained using standard laboratory equipment, even when patterns include relatively few Bragg peaks, provided that the data are of good quality in terms of high counts and low and smooth background.« less

Flight test experience with pilot-induced-oscillation suppressor filters

NASA Technical Reports Server (NTRS)

Shafer, M. F.; Smith, R. E.; Stewart, J. F.; Bailey, R. E.

1983-01-01

Digital flight control systems are popular for their flexibility, reliability, and power; however, their use sometimes results in deficient handling qualities, including pilot-induced oscillation (PIO), which can require extensive redesign of the control system. When redesign is not immediately possible, temporary solutions, such as the PIO suppression (PIOS) filter developed for the Space Shuttle, have been proposed. To determine the effectiveness of such PIOS filters on more conventional, high-performance aircraft, three experiments were performed using the NASA F-8 digital fly-by-wire and USAF/Calspan NT-33 variable-stability aircraft. Two types of PIOS filters were evaluated, using high-gain, precision tasks (close formation, probe-and-drogue refueling, and precision touch-and-go landing) with a time delay or a first-order lag added to make the aircraft prone to PIO. Various configurations of the PIOS filter were evaluated in the flight programs, and most of the PIOS filter configurations reduced the occurrence of PIOs and improved the handling qualities of the PIO-prone aircraft. These experiments also confirmed the influence of high-gain tasks and excessive control system time delay in evoking pilot-induced oscillations.

Size–strain separation in diffraction line profile analysis

DOE PAGES

Scardi, P.; Ermrich, M.; Fitch, A.; ...

2018-05-29

Separation of size and strain effects on diffraction line profiles has been studied in a round robin involving laboratory instruments and synchrotron radiation beamlines operating with different radiation, optics, detectors and experimental configurations. The studied sample, an extensively ball milled iron alloy powder, provides an ideal test case, as domain size broadening and strain broadening are of comparable size. The high energy available at some synchrotron radiation beamlines provides the best conditions for an accurate analysis of the line profiles, as the size–strain separation clearly benefits from a large number of Bragg peaks in the pattern; high counts, reliable intensitymore » values in low-absorption conditions, smooth background and data collection at different temperatures also support the possibility to include diffuse scattering in the analysis, for the most reliable assessment of the line broadening effect. However, results of the round robin show that good quality information on domain size distribution and microstrain can also be obtained using standard laboratory equipment, even when patterns include relatively few Bragg peaks, provided that the data are of good quality in terms of high counts and low and smooth background.« less

Flight test experience with pilot-induced-oscillation suppression filters

NASA Technical Reports Server (NTRS)

Shafer, M. F.; Smith, R. E.; Stewart, J. F.; Bailey, R. E.

1984-01-01

Digital flight control systems are popular for their flexibility, reliability, and power; however, their use sometimes results in deficient handling qualities, including pilot-induced oscillation (PIO), which can require extensive redesign of the control system. When redesign is not immediately possible, temporary solutions, such as the PIO suppression (PIOS) filter developed for the Space Shuttle, have been proposed. To determine the effectiveness of such PIOS filters on more conventional, high-performance aircraft, three experiments were performed using the NASA F-8 digital fly-by-wire and USAF/Calspan NT-33 variable-stability aircraft. Two types of PIOS filters were evaluated, using high-gain, precision tasks (close formation, probe-and-drogue refueling, and precision touch-and-go landing) with a time delay or a first-order lag added to make the aircraft prone to PIO. Various configurations of the PIOS filter were evaluated in the flight programs, and most of the PIOS filter configurations reduced the occurrence of PIOs and improved the handling qualities of the PIO-prone aircraft. These experiments also confirmed the influence of high-gain tasks and excessive control system time delay in evoking pilot-induced oscillations.

75 FR 29976 - Certain Cut-to-Length Carbon-Quality Steel Plate Products From Italy: Extension of the Final...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-28

... DEPARTMENT OF COMMERCE International Trade Administration [A-475-826] Certain Cut-to-Length Carbon... preliminary results of the administrative review of the antidumping duty order on certain cut-to-length carbon-quality steel plate products from Italy. See Certain Cut-to-Length Carbon-Quality Steel Plate Products...

Enabling innovative research by supporting the life cycle of high frequency streaming sensor data in the Global Lake Ecological Observatory Network (GLEON)

NASA Astrophysics Data System (ADS)

Gries, C.; Read, J. S.; Winslow, L. A.; Hanson, P. C.; Weathers, K. C.

2014-12-01

The Global Lake Ecological Observatory Network (GLEON) is an international community of scientists, educators and citizens with the mission to conduct innovative science by sharing and interpreting high-resolution sensor data to understand, predict and communicate the role and response of lakes in a changing global environment. During its almost ten years of existence and continual growth, GLEON has inspired innovative science, new modeling approaches, and accumulated extensive experience in the management of streaming, high resolution, and large volume data. However, a recent 'data task force' identified inhibiting data infrastructure issues, including providing access to data, discovering distributed data, and integrating data into useful data products for scientific research and management. Accordingly, in support of the complete data lifecycle, tools are being developed by the GLEON community and integrated with innovative technology from other groups to improve environmental observations data management in the broader community. Specifically we will discuss raw data handling with tools developed by the Consortium of Universities for the Advancement of Hydrologic Sciences (CUAHSI, Observation Data Model and DataLoader), quality control practices using a newly developed R package (sensorQC), data access with HydroDesktop, or webservices delivering WaterML, data analysis with the R package rLakeAnalyzer, and final storage of the quality controlled, harmonized and value added data product in a DataONE member node. Such data product is then discoverable, accessible for new analyses and citable in subsequent publications. Leveraging GLEON's organizational structure, community trust, extensive experience, and technological talent the goal is to develop a design and implementation plan for a data publishing and sharing system that will address not only GLEON's needs, but also those of other environmental research communities.

Extensive validation of CM SAF surface radiation products over Europe.

PubMed

Urraca, Ruben; Gracia-Amillo, Ana M; Koubli, Elena; Huld, Thomas; Trentmann, Jörg; Riihelä, Aku; Lindfors, Anders V; Palmer, Diane; Gottschalg, Ralph; Antonanzas-Torres, Fernando

2017-09-15

This work presents a validation of three satellite-based radiation products over an extensive network of 313 pyranometers across Europe, from 2005 to 2015. The products used have been developed by the Satellite Application Facility on Climate Monitoring (CM SAF) and are one geostationary climate dataset (SARAH-JRC), one polar-orbiting climate dataset (CLARA-A2) and one geostationary operational product. Further, the ERA-Interim reanalysis is also included in the comparison. The main objective is to determine the quality level of the daily means of CM SAF datasets, identifying their limitations, as well as analyzing the different factors that can interfere in the adequate validation of the products. The quality of the pyranometer was the most critical source of uncertainty identified. In this respect, the use of records from Second Class pyranometers and silicon-based photodiodes increased the absolute error and the bias, as well as the dispersion of both metrics, preventing an adequate validation of the daily means. The best spatial estimates for the three datasets were obtained in Central Europe with a Mean Absolute Deviation (MAD) within 8-13 W/m 2 , whereas the MAD always increased at high-latitudes, snow-covered surfaces, high mountain ranges and coastal areas. Overall, the SARAH-JRC's accuracy was demonstrated over a dense network of stations making it the most consistent dataset for climate monitoring applications. The operational dataset was comparable to SARAH-JRC in Central Europe, but lacked of the temporal stability of climate datasets, while CLARA-A2 did not achieve the same level of accuracy despite predictions obtained showed high uniformity with a small negative bias. The ERA-Interim reanalysis shows the by-far largest deviations from the surface reference measurements.

Constraining Microwave Emission from Extensive Air Showers via the MIDAS Experiment

NASA Astrophysics Data System (ADS)

Richardson, Matthew; Privitera, Paolo

2017-01-01

Ultra high energy cosmic rays (UHECRs) are accelerated by the most energetic processes in the universe. Upon entering Earth’s atmosphere they produce particle showers known as extensive air showers (EASs). Observatories like the Pierre Auger Observatory sample the particles and light produced by the EASs through large particle detector arrays or nitrogen fluorescence detectors to ascertain the fundamental properties of UHECRs. The large sample of high quality data provided by the Pierre Auger Observatory can be attributed to the hybrid technique which utilizes the two aforementioned techniques simultaneously; however, the limitation of only being able to observe nitrogen fluorescence from EASs on clear moonless nights yields a limited 10% duty cycle for the hybrid technique. One proposal for providing high quality data at increased statistics is the observation of isotropic microwave emission from EASs, as such emission would be observed with a 100% duty cycle. Measurements of microwave emission from laboratory air plasmas conducted by Gorham et al. (2008) produced promising results indicating that the microwave emission should be observable using inexpensive detectors. The Microwave Detection of Air Showers (MIDAS) experiment was built at the University of Chicago to characterize the isotropic microwave emission from EASs and has collected 359 days of observational data at the location of the Pierre Auger experiment. We have performed a time coincidence analysis between this data and data from Pierre Auger and we report a null result. This result places stringent limits on microwave emission from EASs and demonstrates that the laboratory measurements of Gorham et al. (2008) are not applicable to EASs, thus diminishing the feasibility of using isotropic microwave emission to detect EASs.

EOS situational data shared service mechanism

NASA Astrophysics Data System (ADS)

Lv, L.; Xu, Q.; Lan, C. Z.; Shi, Q. S.; Lu, W. J.; Wu, W. Q.

2016-11-01

With the rapid development of aerospace and remote sensing technology, various high-resolution Earth Observation Systems (EOS) are widely used in economic, social, military and other fields and playing an increasingly prominent role in the construction of Digital Earth and national strategic planning. The normal operation of the system is the premise of high quality data acquisition. Compared with the ground observation mode, EOS itself and the surrounding environment are more complex, and its operation control mainly depends on all kinds of Space Situational Awareness (SSA) data acquisition and analysis. SSA data has more extensive sources, larger volume, stronger time-effectiveness and more complicated structure than traditional geographical spatial data. For effective data sharing and utilization, combined with the analysis of data types and structures, a SSA data sharing identity language SSDSML is designed based on the extensible mark-up language XML, which realizes a comprehensive description of satellites and their attributes, space environment, ground stations, etc. Then EOS situational data shared service mechanism is established and provides a powerful data support for the normal operation of the system.

75 FR 69049 - Expansion and Extension of the Green Technology Pilot Program

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-10

... environmental quality, energy conservation, development of renewable energy resources, and greenhouse gas... including greenhouse gas reduction (applications pertaining to environmental quality, energy conservation, development of renewable energy resources or greenhouse gas emission reduction) and met other requirements...

Bottom-up low molecular weight heparin analysis using liquid chromatography-Fourier transform mass spectrometry for extensive characterization.

PubMed

Li, Guoyun; Steppich, Julia; Wang, Zhenyu; Sun, Yi; Xue, Changhu; Linhardt, Robert J; Li, Lingyun

2014-07-01

Low molecular weight heparins (LMWHs) are heterogeneous, polydisperse, and highly negatively charged mixtures of glycosaminoglycan chains prescribed as anticoagulants. The detailed characterization of LMWH is important for the drug quality assurance and for new drug research and development. In this study, online hydrophilic interaction chromatography (HILIC) Fourier transform mass spectrometry (FTMS) was applied to analyze the oligosaccharide fragments of LMWHs generated by heparin lyase II digestion. More than 40 oligosaccharide fragments of LMWH were quantified and used to compare LMWHs prepared by three different manufacturers. The quantified fragment structures included unsaturated disaccharides/oligosaccharides arising from the prominent repeating units of these LMWHs, 3-O-sulfo containing tetrasaccharides arising from their antithrombin III binding sites, 1,6-anhydro ring-containing oligosaccharides formed during their manufacture, saturated uronic acid oligosaccharides coming from some chain nonreducing ends, and oxidized linkage region oligosaccharides coming from some chain reducing ends. This bottom-up approach provides rich detailed structural analysis and quantitative information with high accuracy and reproducibility. When combined with the top-down approach, HILIC LC-FTMS based analysis should be suitable for the advanced quality control and quality assurance in LMWH production.

International VLBI Service for Geodesy and Astrometry. Delivering high-quality products and embarking on observations of the next generation

NASA Astrophysics Data System (ADS)

Nothnagel, A.; Artz, T.; Behrend, D.; Malkin, Z.

2017-07-01

The International VLBI Service for Geodesy and Astrometry (IVS) regularly produces high-quality Earth orientation parameters from observing sessions employing extensive networks or individual baselines. The master schedule is designed according to the telescope days committed by the stations and by the need for dense sampling of the Earth orientation parameters (EOP). In the pre-2011 era, the network constellations with their number of telescopes participating were limited by the playback and baseline capabilities of the hardware (Mark4) correlators. This limitation was overcome by the advent of software correlators, which can now accommodate many more playback units in a flexible configuration. In this paper, we describe the current operations of the IVS with special emphasis on the quality of the polar motion results since these are the only EOP components which can be validated against independent benchmarks. The polar motion results provided by the IVS have improved continuously over the years, now providing an agreement with IGS results at the level of 20-25 μas in a WRMS sense. At the end of the paper, an outlook is given for the realization of the VLBI Global Observing System.

Assessment of the nutritional status of Nigerian rural children and mothers' perceptions of quality of life.

PubMed

Ojofeitimi, E O

1984-01-01

One hundred and fourteen preschool school children and their 30 mothers from three selected villages in Ile-Ife, Nigeria were assessed for nutritional status using selected and sensitive anthropometric techniques. The mothers' dietary patterns, their perceptions as to components of a good quality of life, infants' immunization status and major cause of infant death were also examined. Approximately 56% of the children and 80% of the women were identified to be suffering from mild to moderate malnutrition. The major cause of infant death as reported by the mothers was high fever and convulsion. Practically all the children under 3 years had not received any form of immunization. Ability to have plenty of children, good health and money, were highly perceived as measures of essential components of quality of life by all the mothers, while 20% listed good feeding, housing, clothing, and only 7% listed potable water. The need for effective health services, regular home visits, supplementary feeding programmes for school children and an effective health education campaign on the importance of immunization and nutrition for rural people are discussed. The training of agricultural extension workers in the use of simple anthropometric techniques to identify covert malnutrition is also highlighted.

Influence of various water quality sampling strategies on load estimates for small streams

USGS Publications Warehouse

Robertson, Dale M.; Roerish, Eric D.

1999-01-01

Extensive streamflow and water quality data from eight small streams were systematically subsampled to represent various water‐quality sampling strategies. The subsampled data were then used to determine the accuracy and precision of annual load estimates generated by means of a regression approach (typically used for big rivers) and to determine the most effective sampling strategy for small streams. Estimation of annual loads by regression was imprecise regardless of the sampling strategy used; for the most effective strategy, median absolute errors were ∼30% based on the load estimated with an integration method and all available data, if a regression approach is used with daily average streamflow. The most effective sampling strategy depends on the length of the study. For 1‐year studies, fixed‐period monthly sampling supplemented by storm chasing was the most effective strategy. For studies of 2 or more years, fixed‐period semimonthly sampling resulted in not only the least biased but also the most precise loads. Additional high‐flow samples, typically collected to help define the relation between high streamflow and high loads, result in imprecise, overestimated annual loads if these samples are consistently collected early in high‐flow events.

Occurrence and Distribution of Microcystins in Lake Taihu, China

PubMed Central

Sakai, Hiroshi; Hao, Aimin; Iseri, Yasushi; Wang, Song; Kuba, Takahiro; Zhang, Zhenjia; Katayama, Hiroyuki

2013-01-01

The occurrence and distribution of microcystins were investigated in Lake Taihu, the third largest lake in China. An extensive survey, larger and broader in scale than previous studies, was conducted in summer 2010. The highest microcystin concentration was found at southern part of Taihu, which was newly included in this survey. In northern coastal areas, total cellular concentrations of 20 to 44 μg/L were observed. In northern offshore waters, levels were up to 4.8 μg/L. Microcystin occurrence was highly correlated with chemical oxygen demand, turbidity, and chlorophyll-a. Extracellular/total cellular microcystin (E/T) ratios were calculated and compared to other water quality parameters. A higher correlation was found using E/T ratios than original microcystin values. These results show that algal blooms are having a severe impact on Lake Taihu, and further and extensive monitoring and research are required to suppress blooms effectively. PMID:23853542

[Antiandrogen gynecomastia: an inescapable harm? Radiotherapy: a simple and efficient solution!].

PubMed

Couke, Philippe A; Jichliski, Patrice; Matzinger, Oscar; Ozsahin, Mahmut; Bulling, Shelley M; Zouhair, Abderrahim

2004-01-01

Anti-androgen induced gynecomastia, resulting from a treatment induced imbalance between oestrogens and androgens, is a frequently encountered side effect in the hormonal treatment of patients with prostatic cancer. One might expect to face an increase in the overall incidence of this side effect in the next-coming years as randomized trials clearly point to the evidence of the therapeutic benefit of anti-androgenic treatment for this prostatic cancer. Gynecomastia is often accompanied by mastodynia and does hamper quality of life. Surgery should be considered for established irreversible gynecomastia characterized by hyalinization and extensive fibrosis. However, radiotherapy is the treatment of choice for gynecomastia at it's early stage, or could eventually be considered as a prophylactic treatment in high risk patients. It is a safe and extremely well tolerated treatment resulting in a high degree of therapeutic success with a demonstrated effect on quality of life as reported in randomized trials. To date no medical treatment is proven effective nor devoid from deleterious effects and licenced for this indication.

Effect of high-humidity hot air impingement blanching (HHAIB) on drying and quality of red pepper (Capsicum annuum L.).

PubMed

Wang, Jun; Fang, Xiao-Ming; Mujumdar, A S; Qian, Jing-Ya; Zhang, Qian; Yang, Xu-Hai; Liu, Yan-Hong; Gao, Zhen-Jiang; Xiao, Hong-Wei

2017-04-01

Effects of high-humidity hot air impingement blanching (HHAIB) under different times (30, 60, 90, 120, 150, 180, 210, and 240s) on drying characteristics and quality attributes of red peppers in terms of surface colour, red pigment content, microstructure and texture were investigated. Results showed that polyphenol oxidase (PPO) residual activity of the samples decreased with increasing blanching time; it was decreased to 7% after 120s. A first-order fraction model described PPO inactivation well. Suitable HHAIB time can reduce drying time extensively. Pepper surface colour was influenced by different treatments. In terms of red pigment content, there was no significant difference for blanching time under 120s, whereas over blanching (blanching time ⩾150s) can significantly reduce the red pigment content. Microstructure observations indicate that superficial micro-cracks occur, which explain, why HHAIB enhances drying rate. The firmness, hardness, and gumminess of the samples decreased with increase of HHAIB time. Copyright © 2016 Elsevier Ltd. All rights reserved.

Certified ion implantation fluence by high accuracy RBS.

PubMed

Colaux, Julien L; Jeynes, Chris; Heasman, Keith C; Gwilliam, Russell M

2015-05-07

From measurements over the last two years we have demonstrated that the charge collection system based on Faraday cups can robustly give near-1% absolute implantation fluence accuracy for our electrostatically scanned 200 kV Danfysik ion implanter, using four-point-probe mapping with a demonstrated accuracy of 2%, and accurate Rutherford backscattering spectrometry (RBS) of test implants from our quality assurance programme. The RBS is traceable to the certified reference material IRMM-ERM-EG001/BAM-L001, and involves convenient calibrations both of the electronic gain of the spectrometry system (at about 0.1% accuracy) and of the RBS beam energy (at 0.06% accuracy). We demonstrate that accurate RBS is a definitive method to determine quantity of material. It is therefore useful for certifying high quality reference standards, and is also extensible to other kinds of samples such as thin self-supporting films of pure elements. The more powerful technique of Total-IBA may inherit the accuracy of RBS.

The Centennial Trends Greater Horn of Africa precipitation dataset.

PubMed

Funk, Chris; Nicholson, Sharon E; Landsfeld, Martin; Klotter, Douglas; Peterson, Pete; Harrison, Laura

2015-01-01

East Africa is a drought prone, food and water insecure region with a highly variable climate. This complexity makes rainfall estimation challenging, and this challenge is compounded by low rain gauge densities and inhomogeneous monitoring networks. The dearth of observations is particularly problematic over the past decade, since the number of records in globally accessible archives has fallen precipitously. This lack of data coincides with an increasing scientific and humanitarian need to place recent seasonal and multi-annual East African precipitation extremes in a deep historic context. To serve this need, scientists from the UC Santa Barbara Climate Hazards Group and Florida State University have pooled their station archives and expertise to produce a high quality gridded 'Centennial Trends' precipitation dataset. Additional observations have been acquired from the national meteorological agencies and augmented with data provided by other universities. Extensive quality control of the data was carried out and seasonal anomalies interpolated using kriging. This paper documents the CenTrends methodology and data.

The Centennial Trends Greater Horn of Africa precipitation dataset

USGS Publications Warehouse

Funk, Chris; Nicholson, Sharon E.; Landsfeld, Martin F.; Klotter, Douglas; Peterson, Pete J.; Harrison, Laura

2015-01-01

East Africa is a drought prone, food and water insecure region with a highly variable climate. This complexity makes rainfall estimation challenging, and this challenge is compounded by low rain gauge densities and inhomogeneous monitoring networks. The dearth of observations is particularly problematic over the past decade, since the number of records in globally accessible archives has fallen precipitously. This lack of data coincides with an increasing scientific and humanitarian need to place recent seasonal and multi-annual East African precipitation extremes in a deep historic context. To serve this need, scientists from the UC Santa Barbara Climate Hazards Group and Florida State University have pooled their station archives and expertise to produce a high quality gridded ‘Centennial Trends’ precipitation dataset. Additional observations have been acquired from the national meteorological agencies and augmented with data provided by other universities. Extensive quality control of the data was carried out and seasonal anomalies interpolated using kriging. This paper documents the CenTrends methodology and data.

The CONSORT Statement: Application within and adaptations for orthodontic trials.

PubMed

Pandis, Nikolaos; Fleming, Padhraig S; Hopewell, Sally; Altman, Douglas G

2015-06-01

High-quality randomized controlled trials (RCTs) are an integral part of evidence-based medicine. RCTs are the bricks and mortar of high-quality systematic reviews, which are important determinants of health care policy and clinical practice. For published research to be used most effectively, investigators and authors should follow the guidelines for accurate and transparent reporting of RCTs. The consolidated standards of reporting trials (CONSORT) statement and its extensions are among the most widely used reporting guidelines in biomedical research. CONSORT was adopted by the American Journal of Orthodontics and Dentofacial Orthopedics in 2004. Since 2011, this Journal has been actively implementing compliance with the CONSORT reporting guidelines. The objective of this explanatory article is to highlight the relevance and implications of the various CONSORT items to help authors to achieve CONSORT compliance in their research submissions of RCTs to this and other orthodontic journals. Copyright © 2015 American Association of Orthodontists. Published by Elsevier Inc. All rights reserved.

A fast cross-validation method for alignment of electron tomography images based on Beer-Lambert law.

PubMed

Yan, Rui; Edwards, Thomas J; Pankratz, Logan M; Kuhn, Richard J; Lanman, Jason K; Liu, Jun; Jiang, Wen

2015-11-01

In electron tomography, accurate alignment of tilt series is an essential step in attaining high-resolution 3D reconstructions. Nevertheless, quantitative assessment of alignment quality has remained a challenging issue, even though many alignment methods have been reported. Here, we report a fast and accurate method, tomoAlignEval, based on the Beer-Lambert law, for the evaluation of alignment quality. Our method is able to globally estimate the alignment accuracy by measuring the goodness of log-linear relationship of the beam intensity attenuations at different tilt angles. Extensive tests with experimental data demonstrated its robust performance with stained and cryo samples. Our method is not only significantly faster but also more sensitive than measurements of tomogram resolution using Fourier shell correlation method (FSCe/o). From these tests, we also conclude that while current alignment methods are sufficiently accurate for stained samples, inaccurate alignments remain a major limitation for high resolution cryo-electron tomography. Copyright © 2015 Elsevier Inc. All rights reserved.

A fast cross-validation method for alignment of electron tomography images based on Beer-Lambert law

PubMed Central

Yan, Rui; Edwards, Thomas J.; Pankratz, Logan M.; Kuhn, Richard J.; Lanman, Jason K.; Liu, Jun; Jiang, Wen

2015-01-01

In electron tomography, accurate alignment of tilt series is an essential step in attaining high-resolution 3D reconstructions. Nevertheless, quantitative assessment of alignment quality has remained a challenging issue, even though many alignment methods have been reported. Here, we report a fast and accurate method, tomoAlignEval, based on the Beer-Lambert law, for the evaluation of alignment quality. Our method is able to globally estimate the alignment accuracy by measuring the goodness of log-linear relationship of the beam intensity attenuations at different tilt angles. Extensive tests with experimental data demonstrated its robust performance with stained and cryo samples. Our method is not only significantly faster but also more sensitive than measurements of tomogram resolution using Fourier shell correlation method (FSCe/o). From these tests, we also conclude that while current alignment methods are sufficiently accurate for stained samples, inaccurate alignments remain a major limitation for high resolution cryo-electron tomography. PMID:26455556

Newspaper Reporting on a Cluster of Suicides in the UK.

PubMed

John, Ann; Hawton, Keith; Gunnell, David; Lloyd, Keith; Scourfield, Jonathan; Jones, Phillip A; Luce, Ann; Marchant, Amanda; Platt, Steve; Price, Sian; Dennis, Michael S

2017-01-01

Media reporting may influence suicide clusters through imitation or contagion. In 2008 there was extensive national and international newspaper coverage of a cluster of suicides in young people in the Bridgend area of South Wales, UK. To explore the quantity and quality of newspaper reporting during the identified cluster. Searches were conducted for articles on suicide in Bridgend for 6 months before and after the defined cluster (June 26, 2007, to September 16, 2008). Frequency, quality (using the PRINTQUAL instrument), and sensationalism were examined. In all, 577 newspaper articles were identified. One in seven articles included the suicide method in the headline, 47.3% referred to earlier suicides, and 44% used phrases that guidelines suggest should be avoided. Only 13% included sources of information or advice. A high level of poor-quality and sensationalist reporting was found during an ongoing suicide cluster at the very time when good-quality reporting could be considered important. A broad awareness of media guidelines and expansion and adherence to press codes of practice are required by journalists to ensure ethical reporting.

Regulation of assimilate partitioning by daylength and spectral quality

NASA Technical Reports Server (NTRS)

Britz, Steve J.

1994-01-01

The effects of daylength and spectral quality on assimilate partitioning and leaf carbohydrate content should be considered when conducting controlled environment experiments or comparing results between studies obtained under different lighting conditions. Changes in partitioning may indicate alterations to photoregulatory processes within the source leaf rather than disruptions in sink strength. Moreover, it may be possible to use photoregulatory responses of assimilate partitioning to probe mechanisms of growth and development involving translocation of carbon or adaptation to environmental factors such as elevated CO2. It may also be possible to steer assimilate partitioning for the benefit of controlled environment agriculture using energy-efficient manipulations such as daylength extensions with dim irradiances, end-of-day alterations in light quality, or shifting plants between different spectral qualities as a part of phasic control of growth and development. Note that high starch levels measured on a one-time basis provide little information, since it is the proportion of photosynthate stored as starch that is meaningful. Large differences in starch content can result from small changes in partitioning integrated over several days. Rate information is required.

Development of Prior Image-Based, High-Quality, Low-Dose Kilovoltage Cone Beam CT for Use in Adaptive Radiotherapy of Prostate Cancer

DTIC Science & Technology

2013-05-01

for initial test of object coverage for these scanning trajectories. I have also acquired real data of physical phantoms by using a clinical CBCT system...scan. To test the extension of axial coverage, I car- ried out a simulated data study using numerical disk and anthropomorphic XCAT phantoms [15]. As an...imaging model in Eq. (1), I investigated the choice of data divergence, such as the Euclidean distance or Kullback - Leibler (K-L) divergence, which are

Hit discovery and hit-to-lead approaches.

PubMed

Keseru, György M; Makara, Gergely M

2006-08-01

Hit discovery technologies range from traditional high-throughput screening to affinity selection of large libraries, fragment-based techniques and computer-aided de novo design, many of which have been extensively reviewed. Development of quality leads using hit confirmation and hit-to-lead approaches present their own challenges, depending on the hit discovery method used to identify the initial hits. In this paper, we summarize common industry practices adopted to tackle hit-to-lead challenges and review how the advantages and drawbacks of different hit discovery techniques could affect the various issues hit-to-lead groups face.

Cross-polarized wave generation (XPW) for ultrafast laser pulse characterization and intensity contrast enhancement

NASA Astrophysics Data System (ADS)

Iliev, Marin

Good pulse quality, high peak power and tunable central wavelength are amongst the most desired qualities in modern lasers. The nonlinear effect cross-polarized wave generation (XPW), can be used in ultrafast laser systems to achieve various pulse quality enhancements. The XPW yield depends on the cube of the input intensity and acts as a spatio-temporal filter. It is orthogonally polarized to the input pulse and highly Gaussian. If the input pulse is well compressed, the output spectrum is smoother and broader. These features make XPW an ideal reference signal in pulse characterization techniques. This thesis presents a detailed analysis of the XPW conversion process, and describes novel applications to pulse characterization and high-quality pulse cleaning. An extensive computer model was developed to describe XPW generation via solution of the full coupled non-linear differential equations. The model accounts for dispersion inside the nonlinear crystal and uses split-step Fourier optics beam propagation to simulate the evolution of the electro-magnetic fields of the pump and XPW through free-space and imaging systems. A novel extension to the self-referenced spectral interferometry (SRSI) pulse characterization technique allows the retrieval of the energy and spectral content of the amplified spontaneous emission (ASE) present in ultrashort pulse amplifier systems. A novel double-pass XPW conversion scheme is presented. In it the beam passes through a single XPW crystal (BaF2) and is re-imaged with a curved mirror. The technique resulted in good (˜30%) efficiency without the spatial aberrations commonly seen in another arrangement that uses two crystals in succession. The modeling sheds light on the complicated nonlinear beam dynamics of the double-crystal conversion, including self- and cross-phase modulation, self-focusing, and the effects of, relative on-axis phase-difference, relative beam sizes, and wave-front curvature matching on seeded XPW conversion. Finally, a design is presented for exploiting the clean-up properties of XPW at the output of an optical parametric generation (OPA) setup in conjunction with an extremely compact prism compressor. The prisms material, separation and geometry are designed carefully to work at the correct wavelength of the OPA setup and are extrapolated to accommodate wavelengths, such as 2mum of parametric wave generation.

Five of Five VHHs Neutralizing Poliovirus Bind the Receptor-Binding Site

PubMed Central

Strauss, Mike; Schotte, Lise; Thys, Bert; Filman, David J.

2016-01-01

ABSTRACT Nanobodies, or VHHs, that recognize poliovirus type 1 have previously been selected and characterized as candidates for antiviral agents or reagents for standardization of vaccine quality control. In this study, we present high-resolution cryo-electron microscopy reconstructions of poliovirus with five neutralizing VHHs. All VHHs bind the capsid in the canyon at sites that extensively overlap the poliovirus receptor-binding site. In contrast, the interaction involves a unique (and surprisingly extensive) surface for each of the five VHHs. Five regions of the capsid were found to participate in binding with all five VHHs. Four of these five regions are known to alter during the expansion of the capsid associated with viral entry. Interestingly, binding of one of the VHHs, PVSS21E, resulted in significant changes of the capsid structure and thus seems to trap the virus in an early stage of expansion. IMPORTANCE We describe the cryo-electron microscopy structures of complexes of five neutralizing VHHs with the Mahoney strain of type 1 poliovirus at resolutions ranging from 3.8 to 6.3Å. All five VHHs bind deep in the virus canyon at similar sites that overlap extensively with the binding site for the receptor (CD155). The binding surfaces on the VHHs are surprisingly extensive, but despite the use of similar binding surfaces on the virus, the binding surface on the VHHs is unique for each VHH. In four of the five complexes, the virus remains essentially unchanged, but for the fifth there are significant changes reminiscent of but smaller in magnitude than the changes associated with cell entry, suggesting that this VHH traps the virus in a previously undescribed early intermediate state. The neutralizing mechanisms of the VHHs and their potential use as quality control agents for the end game of poliovirus eradication are discussed. PMID:26764003

Five of Five VHHs Neutralizing Poliovirus Bind the Receptor-Binding Site.

PubMed

Strauss, Mike; Schotte, Lise; Thys, Bert; Filman, David J; Hogle, James M

2016-01-13

Nanobodies, or VHHs, that recognize poliovirus type 1 have previously been selected and characterized as candidates for antiviral agents or reagents for standardization of vaccine quality control. In this study, we present high-resolution cryo-electron microscopy reconstructions of poliovirus with five neutralizing VHHs. All VHHs bind the capsid in the canyon at sites that extensively overlap the poliovirus receptor-binding site. In contrast, the interaction involves a unique (and surprisingly extensive) surface for each of the five VHHs. Five regions of the capsid were found to participate in binding with all five VHHs. Four of these five regions are known to alter during the expansion of the capsid associated with viral entry. Interestingly, binding of one of the VHHs, PVSS21E, resulted in significant changes of the capsid structure and thus seems to trap the virus in an early stage of expansion. We describe the cryo-electron microscopy structures of complexes of five neutralizing VHHs with the Mahoney strain of type 1 poliovirus at resolutions ranging from 3.8 to 6.3Å. All five VHHs bind deep in the virus canyon at similar sites that overlap extensively with the binding site for the receptor (CD155). The binding surfaces on the VHHs are surprisingly extensive, but despite the use of similar binding surfaces on the virus, the binding surface on the VHHs is unique for each VHH. In four of the five complexes, the virus remains essentially unchanged, but for the fifth there are significant changes reminiscent of but smaller in magnitude than the changes associated with cell entry, suggesting that this VHH traps the virus in a previously undescribed early intermediate state. The neutralizing mechanisms of the VHHs and their potential use as quality control agents for the end game of poliovirus eradication are discussed. Copyright © 2016, American Society for Microbiology. All Rights Reserved.

Water quality and quantity investigation of green roofs in a dry climate.

PubMed

Beecham, S; Razzaghmanesh, M

2015-03-01

Low-energy pollutant removal strategies are now being sought for water sensitive urban design. This paper describes investigations into the water quality and quantity of sixteen, low-maintenance and unfertilized intensive and extensive green roof beds. The factors of Slope (1° and 25°), Depth (100 mm and 300 mm), Growing media (type A, type B and type C) and Species (P1, P2 and P3) were randomized according to a split-split plot design. This consisted of twelve vegetated green roof beds and four non-vegetated beds as controls. Stormwater runoff was collected from drainage points that were installed in each area. Samples of run-off were collected for five rainfall events and analysed for water retention capacity and the water quality parameters of NO₂, NO₃, NH₄, PO₄, pH, EC, TDS, Turbidity, Na, Ca, Mg and K. The results indicated significant differences in terms of stormwater water quality and quantity between the outflows of vegetated and non-vegetated systems. The water retention was between 51% and 96% and this range was attributed to the green roof configurations in the experiment. Comparing the quality of rainfall as inflow, and the quality of runoff from the systems showed that green roofs generally acted as a source of pollutants in this study. In the vegetated beds, the intensive green roofs performed better than the extensive beds with regard to outflow quality while in the non-vegetated beds, the extensive beds performed better than intensive systems. This highlights the importance of vegetation in improving water retention capacity as well as the role of vegetation in enhancing pollutant removal in green roof systems. In addition growing media with less organic matter had better water quality performance. Comparison of these results with national and international standards for water reuse confirmed that the green roof outflow was suitable for non-potable uses such as landscape irrigation and toilet flushing. Copyright © 2014 Elsevier Ltd. All rights reserved.

77 FR 2677 - EPA Responses to State and Tribal 2008 Ozone Designation Recommendations; Extension of Public...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-01-19

... State and Tribal 2008 Ozone Designation Recommendations; Extension of Public Comment Period AGENCY... and tribal ozone designation recommendations for the 2008 Ozone National Ambient Air Quality Standards... designation determinations for the 2008 ozone standards in spring 2012. DATES: Comments must be received on or...

76 FR 32968 - Proposed Extensions and Waivers: National Center To Enhance the Professional Development of...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-07

... quality of special education personnel training and professional development. The goal is to help ensure... access to, and greater participation and progress in, the general education curriculum in the least... DEPARTMENT OF EDUCATION [CFDA No. 84.325F] Proposed Extensions and Waivers: National Center To...

75 FR 46881 - Approval and Promulgation of Implementation Plans; Extension of Attainment Date for the Charlotte...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-04

... ENVIRONMENTAL PROTECTION AGENCY 40 CFR Part 81 [EPA-R04-OAR-2010-0504-201029; FRL-9185-1] Approval and Promulgation of Implementation Plans; Extension of Attainment Date for the Charlotte-Gastonia-Rock... national ambient air quality standards (NAAQS) for the Charlotte-Gastonia-Rock Hill, North Carolina-South...

Boundary-Spanning Actors in Urban 4-H: An Action Research Case Study

ERIC Educational Resources Information Center

David, Victoria Dotson

2014-01-01

Today's Cooperative Extension organization continues to face challenges of providing relevant, quality programming in urban communities. Challenges include the ability to build capacity in Extension's urban youth educators to assess and interpret the unique, variable needs of urban clients and to communicate effectively the identified…

76 FR 24060 - Proposed Extension of Existing Information Collection; Testing, Evaluation, and Approval of...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-29

... Extension of Existing Information Collection; Testing, Evaluation, and Approval of Mining Products AGENCY... Reduction Act of 1995 [44 U.S.C. 3506(c)(2)(A)]. This program helps to ensure that requested data can be..., testing, approval and certification, and quality control of mining equipment and components, materials...

Groundwater quality and depletion in the Indo-Gangetic Basin mapped from in situ observations

NASA Astrophysics Data System (ADS)

MacDonald, A. M.; Bonsor, H. C.; Ahmed, K. M.; Burgess, W. G.; Basharat, M.; Calow, R. C.; Dixit, A.; Foster, S. S. D.; Gopal, K.; Lapworth, D. J.; Lark, R. M.; Moench, M.; Mukherjee, A.; Rao, M. S.; Shamsudduha, M.; Smith, L.; Taylor, R. G.; Tucker, J.; van Steenbergen, F.; Yadav, S. K.

2016-10-01

Groundwater abstraction from the transboundary Indo-Gangetic Basin comprises 25% of global groundwater withdrawals, sustaining agricultural productivity in Pakistan, India, Nepal and Bangladesh. Recent interpretations of satellite gravity data indicate that current abstraction is unsustainable, yet these large-scale interpretations lack the spatio-temporal resolution required to govern groundwater effectively. Here we report new evidence from high-resolution in situ records of groundwater levels, abstraction and groundwater quality, which reveal that sustainable groundwater supplies are constrained more by extensive contamination than depletion. We estimate the volume of groundwater to 200 m depth to be >20 times the combined annual flow of the Indus, Brahmaputra and Ganges, and show the water table has been stable or rising across 70% of the aquifer between 2000 and 2012. Groundwater levels are falling in the remaining 30%, amounting to a net annual depletion of 8.0 +/- 3.0 km3. Within 60% of the aquifer, access to potable groundwater is restricted by excessive salinity or arsenic. Recent groundwater depletion in northern India and Pakistan has occurred within a longer history of groundwater accumulation from extensive canal leakage. This basin-wide synthesis of in situ groundwater observations provides the spatial detail essential for policy development, and the historical context to help evaluate recent satellite gravity data.

Parent and Youth Priorities during the Transition to Adulthood for Youth with Special Health Care Needs and Developmental Disability

PubMed Central

Rehm, Roberta S.; Fuentes-Afflick, Elena; Fisher, Lucille T.; Chesla, Catherine A.

2014-01-01

Families undertake extensive planning during transition to adulthood so youth with concomitant special health care needs and developmental disabilities will have a long-term high quality of life. Findings from an interpretive field study involving 64 youth and their parents indicated that the meaning of adulthood was functioning as independently as possible with appropriate supports. Parental priorities included protecting health, assuring safety and security in multiple realms, finding meaningful activities after high school, and establishing supportive social relationships. These priorities demonstrated the need to broaden usual health care transition goals that focus on finding adult providers and optimizing self-management. PMID:22869218

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhang, Jie; He, Yunteng; Kong, Wei, E-mail: wei.kong@oregonstate.edu

We report electron diffraction of ferrocene doped in superfluid helium droplets. By taking advantage of the velocity slip in our pulsed droplet beam using a pulsed electron gun, and by doping with a high concentration of ferrocene delivered via a pulsed valve, we can obtain high quality diffraction images from singly doped droplets. Under the optimal doping conditions, 80% of the droplets sampled in the electron beam are doped with just one ferrocene molecule. Extension of this size selection method to dopant clusters has also been demonstrated. However, incomplete separation of dopant clusters might require deconvolution and modeling of themore » doping process. This method can be used for studies of nucleation processes in superfluid helium droplets.« less

Quality of clinical and economic evidence in dossier formulary submissions.

PubMed

Colmenero, Fernando; Sullivan, Sean D; Palmer, Jennifer A; Brauer, Carmen A; Bungay, Kathleen; Watkins, John; Neumann, Peter J

2007-07-01

To investigate the quality and completeness of clinical and economic data in dossiers submitted by drug companies to a health plan using Academy of Managed Care Pharmacy guidelines (the Format) for formulary submissions. We reviewed the quality of economic analyses in dossiers submitted to Premera Blue Cross Health Plan (Mountlake Terrace, Washington; enrollment 1.6 million) between January 2002 and September 2005. For dossiers submitted in 2003, we examined the clinical studies included. Dossiers were audited with a data collection form to judge the types of clinical studies used to support labeled and off-label indications, and the quality and transparency of economic analyses. We compared economic analyses for high-cost (30-day treatment cost > $1000) versus low-cost products, and for "innovative" versus "me-too" drugs. Evidence to support off-label indications often was included in 2003 dossiers, but the information was less extensive and of poorer quality than data for labeled indications. Of 115 dossiers submitted between 2002 and 2005, 53 (46%) included economic analyses. The economic analyses had low levels of compliance with standards: only 43% performed sensitivity analysis; 38% stated the study perspective; 37% discussed relevant treatment alternatives; 20% stated assumptions clearly; and 18% mentioned caveats to conclusions. Economic analyses of high-cost products and innovative products had higher compliance with recommended practices. Drug companies are submitting dossiers of evidence to formulary committees. Dossiers often included clinical data to support off-label indications, but concerns persist about their quality. About half of dossiers included economic analyses, but these analyses had relatively low levels of compliance with recommended practices.

Communicating and visualizing data quality through Web Map Services

NASA Astrophysics Data System (ADS)

Roberts, Charles; Blower, Jon; Maso, Joan; Diaz, Daniel; Griffiths, Guy; Lewis, Jane

2014-05-01

The sharing and visualization of environmental data through OGC Web Map Services is becoming increasingly common. However, information about the quality of data is rarely presented. (In this presentation we consider mostly data uncertainty as a measure of quality, although we acknowledge that many other quality measures are relevant to the geoscience community.) In the context of the GeoViQua project (http://www.geoviqua.org) we have developed conventions and tools for using WMS to deliver data quality information. The "WMS-Q" convention describes how the WMS specification can be used to publish quality information at the level of datasets, variables and individual pixels (samples). WMS-Q requires no extensions to the WMS 1.3.0 specification, being entirely backward-compatible. (An earlier version of WMS-Q was published as OGC Engineering Report 12-160.) To complement the WMS-Q convention, we have also developed extensions to the OGC Symbology Encoding (SE) specification, enabling uncertain geoscience data to be portrayed using a variety of visualization techniques. These include contours, stippling, blackening, whitening, opacity, bivariate colour maps, confidence interval triangles and glyphs. There may also be more extensive applications of these methods beyond the visual representation of uncertainty. In this presentation we will briefly describe the scope of the WMS-Q and "extended SE" specifications and then demonstrate the innovations using open-source software based upon ncWMS (http://ncwms.sf.net). We apply the tools to a variety of datasets including Earth Observation data from the European Space Agency's Climate Change Initiative. The software allows uncertain raster data to be shared through Web Map Services, giving the user fine control over data visualization.

Influence of Structural Features on Portuguese Toddler Child Care Quality

ERIC Educational Resources Information Center

Pessanha, Manuela; Aguiar, Cecilia; Bairrao, Joaquim

2007-01-01

Whereas child care quality has been extensively studied in the U.S., there is much less information about the quality of child care in other countries. With one of the highest maternal employment rates in Europe, it is important to examine child care in Portugal. Thirty toddler classrooms in child care centers were observed. The purpose of this…

Understanding the effectiveness of vegetated streamside management zones for protecting water quality (Chapter 5)

Treesearch

Philip Smethurst; Kevin Petrone; Daniel Neary

2012-01-01

We set out to improve understanding of the effectiveness of streamside management zones (SMZs) for protecting water quality in landscapes dominated by agriculture. We conducted a paired-catchment experiment that included water quality monitoring before and after the establishment of a forest plantation as an SMZ on cleared farmland that was used for extensive grazing....

Quality assurance in pathology in colorectal cancer screening and diagnosis—European recommendations

PubMed Central

Quirke, Phil; Risio, Mauro; Lambert, René; von Karsa, Lawrence

2010-01-01

In Europe, colorectal cancer is the most common newly diagnosed cancer and the second most common cause of cancer deaths, accounting for approximately 436,000 incident cases and 212,000 deaths in 2008. The potential of high-quality screening to improve control of the disease has been recognized by the Council of the European Union who issued a recommendation on cancer screening in 2003. Multidisciplinary, evidence-based European Guidelines for quality assurance in colorectal cancer screening and diagnosis have recently been developed by experts in a pan-European project coordinated by the International Agency for Research on Cancer. The full guideline document consists of ten chapters and an extensive evidence base. The content of the chapter dealing with pathology in colorectal cancer screening and diagnosis is presented here in order to promote international discussion and collaboration leading to improvements in colorectal cancer screening and diagnosis by making the principles and standards recommended in the new EU Guidelines known to a wider scientific community. PMID:21061133

Modeling Ghanaian cocoa farmers' decision to use pesticide and frequency of application: the case of Brong Ahafo Region.

PubMed

Denkyirah, Elisha Kwaku; Okoffo, Elvis Dartey; Adu, Derick Taylor; Aziz, Ahmed Abdul; Ofori, Amoako; Denkyirah, Elijah Kofi

2016-01-01

Pesticides are a significant component of the modern agricultural technology that has been widely adopted across the globe to control pests, diseases, weeds and other plant pathogens, in an effort to reduce or eliminate yield losses and maintain high product quality. Although pesticides are said to be toxic and exposes farmers to risk due to the hazardous effects of these chemicals, pesticide use among cocoa farmers in Ghana is still high. Furthermore, cocoa farmers do not apply pesticide on their cocoa farms at the recommended frequency of application. In view of this, the study assessed the factors influencing cocoa farmers' decision to use pesticide and frequency of pesticide application. A total of 240 cocoa farmers from six cocoa growing communities in the Brong Ahafo Region of Ghana were selected for the study using the multi-stage sampling technique. The Probit and Tobit regression models were used to estimate factors influencing farmers' decision to use pesticide and frequency of pesticide application, respectively. Results of the study revealed that the use of pesticide is still high among farmers in the Region and that cocoa farmers do not follow the Ghana Cocoa Board recommended frequency of pesticide application. In addition, cocoa farmers in the study area were found to be using both Ghana Cocoa Board approved/recommended and unapproved pesticides for cocoa production. Gender, age, educational level, years of farming experience, access to extension service, availability of agrochemical shop and access to credit significantly influenced farmers' decision to use pesticides. Also, educational level, years of farming experience, membership of farmer based organisation, access to extension service, access to credit and cocoa income significantly influenced frequency of pesticide application. Since access to extension service is one key factor that reduces pesticide use and frequency of application among cocoa farmers, it is recommended that policies by government and non-governmental organisations should be aimed at mobilizing resources towards the expansion of extension education. In addition, extension service should target younger farmers as well as provide information on alternative pest control methods in order to reduce pesticide use among cocoa farmers. Furthermore, extension service/agents should target cocoa farmers with less years of farming experience and encourage cocoa farmers to join farmer based organisations in order to decrease frequency of pesticide application.

Motion Path of the Instant Center of Rotation in the Cervical Spine During In Vivo Dynamic Flexion-Extension: Implications for Artificial Disc Design and Evaluation of Motion Quality Following Arthrodesis

PubMed Central

Anderst, William; Baillargeon, Emma; Donaldson, William; Lee, Joon; Kang, James

2013-01-01

Study Design Case-control. Objective To characterize the motion path of the instant center of rotation (ICR) at each cervical motion segment from C2 to C7 during dynamic flexion-extension in asymptomatic subjects. To compare asymptomatic and single-level arthrodesis patient ICR paths. Summary of Background Data The ICR has been proposed as an alternative to range of motion (ROM) for evaluating the quality of spine movement and for identifying abnormal midrange kinematics. The motion path of the ICR during dynamic motion has not been reported. Methods 20 asymptomatic controls, 12 C5/C6 and 5 C6/C7 arthrodesis patients performed full ROM flexion-extension while biplane radiographs were collected at 30 Hz. A previously validated tracking process determined three-dimensional vertebral position with sub-millimeter accuracy. The finite helical axis method was used to calculate the ICR between adjacent vertebrae. A linear mixed-model analysis identified differences in the ICR path among motion segments and between controls and arthrodesis patients. Results From C2/C3 to C6/C7, the mean ICR location moved superior for each successive motion segment (p < .001). The AP change in ICR location per degree of flexion-extension decreased from the C2/C3 motion segment to the C6/C7 motion segment (p < .001). Asymptomatic subject variability (95% CI) in the ICR location averaged ±1.2 mm in the SI direction and ±1.9 mm in the AP direction over all motion segments and flexion-extension angles. Asymptomatic and arthrodesis groups were not significantly different in terms of average ICR position (all p ≥ .091) or in terms of the change in ICR location per degree of flexion-extension (all p ≥ .249). Conclusions To replicate asymptomatic in vivo cervical motion, disc replacements should account for level-specific differences in the location and motion path of ICR. Single-level anterior arthrodesis does not appear to affect cervical motion quality during flexion-extension. PMID:23429677

Fertilization effects on Tifton 85 bermudagrass quantity and quality

USDA-ARS?s Scientific Manuscript database

Most fertilization recommendations for forage bermudagrass (Cynodon dactylon L.) are based on extensive research with ‘Coastal’ bermudagrass which is grown throughout the Southeastern United States since its release in 1943. Tifton 85, having higher yields and better forage quality, was released in...

Selecting a sterilisation subcontractor.

PubMed

Donawa, M

2001-03-01

Medical device manufacturers who need contract sterilisation services sometimes lack extensive knowledge of the technical aspects of sterilisation processes. For this reason, they may have problems assessing quality requirements for subcontractor sterilisation services. This article discusses important quality issues that should be considered when selecting a sterilisation subcontractor.

77 FR 15052 - National Ocean Council-National Ocean Policy Draft Implementation Plan

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-14

... COUNCIL ON ENVIRONMENTAL QUALITY National Ocean Council--National Ocean Policy Draft Implementation Plan AGENCY: Council on Environmental Quality. ACTION: Extension of comment period. SUMMARY: On July 19, 2010, President Obama signed Executive Order 13547 establishing a National Policy for the...

Modified Atmosphere Systems and Shelf Life Extension of Fish and Fishery Products

PubMed Central

DeWitt, Christina A. Mireles; Oliveira, Alexandra C.M.

2016-01-01

This review aims at summarizing the findings of studies published over the past 15 years on the application of modified atmosphere (MA) systems for shelf life extension of fish and fishery products. This review highlights the importance of CO2 in the preservation of seafood products, and underscores the benefits of combining MA technology with product storage in the superchilled temperature range. It is generally accepted that MA technology cannot improve product quality and should not be utilized as a substitute for good sanitation and strict temperature control. Benefits derived from application of MA, however, can significantly impact preservation of product quality and it subsequent shelf-life. For this reason, this review is the first of its kind to propose detailed handling and quality guidelines for fresh fish to realize the maximum benefit of MA technology. PMID:28231143

Remote tele-mentored ultrasound for non-physician learners using FaceTime: A feasibility study in a low-income country.

PubMed

Robertson, Thomas E; Levine, Andrea R; Verceles, Avelino C; Buchner, Jessica A; Lantry, James H; Papali, Alfred; Zubrow, Marc T; Colas, L Nathalie; Augustin, Marc E; McCurdy, Michael T

2017-08-01

Ultrasound (US) is a burgeoning diagnostic tool and is often the only available imaging modality in low- and middle-income countries (LMICs). However, bedside providers often lack training to acquire or interpret US images. We conducted a study to determine if a remote tele-intensivist could mentor geographically removed LMIC providers to obtain quality and clinically useful US images. Nine Haitian non-physician health care workers received a 20-minute training on basic US techniques. A volunteer was connected to an intensivist located in the USA via FaceTime. The intensivist remotely instructed the non-physicians to ultrasound five anatomic sites. The tele-intensivist evaluated the image quality and clinical utility of performing tele-ultrasound in a LMIC. The intensivist agreed (defined as "agree" or "strongly agree" on a five-point Likert scale) that 90% (57/63) of the FaceTime images were high quality. The intensivist felt comfortable making clinical decisions using FaceTime images 89% (56/63) of the time. Non-physicians can feasibly obtain high-quality and clinically relevant US images using video chat software in LMICs. Commercially available software can connect providers in institutions in LMICs to geographically removed intensivists at a relatively low cost and without the need for extensive training of local providers. Copyright © 2017 Elsevier Inc. All rights reserved.

Process mapping as a framework for performance improvement in emergency general surgery.

PubMed

DeGirolamo, Kristin; D'Souza, Karan; Hall, William; Joos, Emilie; Garraway, Naisan; Sing, Chad Kim; McLaughlin, Patrick; Hameed, Morad

2017-12-01

Emergency general surgery conditions are often thought of as being too acute for the development of standardized approaches to quality improvement. However, process mapping, a concept that has been applied extensively in manufacturing quality improvement, is now being used in health care. The objective of this study was to create process maps for small bowel obstruction in an effort to identify potential areas for quality improvement. We used the American College of Surgeons Emergency General Surgery Quality Improvement Program pilot database to identify patients who received nonoperative or operative management of small bowel obstruction between March 2015 and March 2016. This database, patient charts and electronic health records were used to create process maps from the time of presentation to discharge. Eighty-eight patients with small bowel obstruction (33 operative; 55 nonoperative) were identified. Patients who received surgery had a complication rate of 32%. The processes of care from the time of presentation to the time of follow-up were highly elaborate and variable in terms of duration; however, the sequences of care were found to be consistent. We used data visualization strategies to identify bottlenecks in care, and they showed substantial variability in terms of operating room access. Variability in the operative care of small bowel obstruction is high and represents an important improvement opportunity in general surgery. Process mapping can identify common themes, even in acute care, and suggest specific performance improvement measures.

Process mapping as a framework for performance improvement in emergency general surgery.

PubMed

DeGirolamo, Kristin; D'Souza, Karan; Hall, William; Joos, Emilie; Garraway, Naisan; Sing, Chad Kim; McLaughlin, Patrick; Hameed, Morad

2018-02-01

Emergency general surgery conditions are often thought of as being too acute for the development of standardized approaches to quality improvement. However, process mapping, a concept that has been applied extensively in manufacturing quality improvement, is now being used in health care. The objective of this study was to create process maps for small bowel obstruction in an effort to identify potential areas for quality improvement. We used the American College of Surgeons Emergency General Surgery Quality Improvement Program pilot database to identify patients who received nonoperative or operative management of small bowel obstruction between March 2015 and March 2016. This database, patient charts and electronic health records were used to create process maps from the time of presentation to discharge. Eighty-eight patients with small bowel obstruction (33 operative; 55 nonoperative) were identified. Patients who received surgery had a complication rate of 32%. The processes of care from the time of presentation to the time of follow-up were highly elaborate and variable in terms of duration; however, the sequences of care were found to be consistent. We used data visualization strategies to identify bottlenecks in care, and they showed substantial variability in terms of operating room access. Variability in the operative care of small bowel obstruction is high and represents an important improvement opportunity in general surgery. Process mapping can identify common themes, even in acute care, and suggest specific performance improvement measures.

Photonic Diagnostic Technique For Thin Photoactive Films

NASA Technical Reports Server (NTRS)

Thakoor, Sarita

1996-01-01

Photonic diagnostic technique developed for use in noninvasive, rapid evaluation of thin paraelectric/ferroelectric films. Method proves useful in basic research, on-line monitoring for quality control at any stage of fabrication, and development of novel optoelectronic systems. Used to predict imprint-prone memory cells, and to study time evolution of defects in ferroelectric memories during processing. Plays vital role in enabling high-density ferroelectric memory manufacturing. One potential application lies in use of photoresponse for nondestructive readout of polarization memory states in high-density, high-speed memory devices. In another application, extension of basic concept of method makes possible to develop specially tailored ferrocapacitor to act as programmable detector, wherein remanent polarization used to modulate photoresponse. Large arrays of such detectors useful in optoelectronic processing, computing, and communication.

12 CFR 32.7 - Residential real estate loans, small business loans, and small farm loans.

Code of Federal Regulations, 2010 CFR

2010-01-01

... total outstanding amount of a national bank's loans and extensions of credit to one borrower made under... surplus. (5) The total outstanding amount of a national bank's loans and extensions of credit to all of... concerns about credit quality, undue concentrations in the bank's portfolio of residential real estate...

Farmer Perceptions of Soil and Water Conservation Issues: Implications to Agricultural and Extension Education.

ERIC Educational Resources Information Center

Bruening, Thomas; Martin, Robert A.

1992-01-01

A survey of 731 Iowa farmers received 432 responses indicating that (1) groundwater and water quality were of greater concern than soil conservation; (2) field demonstrations and county meetings were useful information sources on these issues; and (3) government agencies such as cooperative extension and state universities were useful sources of…

Guidelines for Inclusion of Patient-Reported Outcomes in Clinical Trial Protocols: The SPIRIT-PRO Extension.

PubMed

Calvert, Melanie; Kyte, Derek; Mercieca-Bebber, Rebecca; Slade, Anita; Chan, An-Wen; King, Madeleine T; Hunn, Amanda; Bottomley, Andrew; Regnault, Antoine; Chan, An-Wen; Ells, Carolyn; O'Connor, Daniel; Revicki, Dennis; Patrick, Donald; Altman, Doug; Basch, Ethan; Velikova, Galina; Price, Gary; Draper, Heather; Blazeby, Jane; Scott, Jane; Coast, Joanna; Norquist, Josephine; Brown, Julia; Haywood, Kirstie; Johnson, Laura Lee; Campbell, Lisa; Frank, Lori; von Hildebrand, Maria; Brundage, Michael; Palmer, Michael; Kluetz, Paul; Stephens, Richard; Golub, Robert M; Mitchell, Sandra; Groves, Trish

2018-02-06

Patient-reported outcome (PRO) data from clinical trials can provide valuable evidence to inform shared decision making, labeling claims, clinical guidelines, and health policy; however, the PRO content of clinical trial protocols is often suboptimal. The SPIRIT (Standard Protocol Items: Recommendations for Interventional Trials) statement was published in 2013 and aims to improve the completeness of trial protocols by providing evidence-based recommendations for the minimum set of items to be addressed, but it does not provide PRO-specific guidance. To develop international, consensus-based, PRO-specific protocol guidance (the SPIRIT-PRO Extension). The SPIRIT-PRO Extension was developed following the Enhancing Quality and Transparency of Health Research (EQUATOR) Network's methodological framework for guideline development. This included (1) a systematic review of existing PRO-specific protocol guidance to generate a list of potential PRO-specific protocol items (published in 2014); (2) refinements to the list and removal of duplicate items by the International Society for Quality of Life Research (ISOQOL) Protocol Checklist Taskforce; (3) an international stakeholder survey of clinical trial research personnel, PRO methodologists, health economists, psychometricians, patient advocates, funders, industry representatives, journal editors, policy makers, ethicists, and researchers responsible for evidence synthesis (distributed by 38 international partner organizations in October 2016); (4) an international Delphi exercise (n = 137 invited; October 2016 to February 2017); and (5) consensus meeting (n = 30 invited; May 2017). Prior to voting, consensus meeting participants were informed of the results of the Delphi exercise and given data from structured reviews evaluating the PRO protocol content of 3 defined samples of trial protocols. The systematic review identified 162 PRO-specific protocol recommendations from 54 sources. The ISOQOL Taskforce (n = 21) reduced this to 56 items, which were considered by 138 international stakeholder survey participants and 99 Delphi panelists. The final wording of the SPIRIT-PRO Extension was agreed on at a consensus meeting (n = 29 participants) and reviewed by external group of experts during a consultation period. Eleven extensions and 5 elaborations to the SPIRIT 2013 checklist were recommended for inclusion in clinical trial protocols in which PROs are a primary or key secondary outcome. Extension items focused on PRO-specific issues relating to the trial rationale, objectives, eligibility criteria, concepts used to evaluate the intervention, time points for assessment, PRO instrument selection and measurement properties, data collection plan, translation to other languages, proxy completion, strategies to minimize missing data, and whether PRO data will be monitored during the study to inform clinical care. The SPIRIT-PRO guidelines provide recommendations for items that should be addressed and included in clinical trial protocols in which PROs are a primary or key secondary outcome. Improved design of clinical trials including PROs could help ensure high-quality data that may inform patient-centered care.

Application of Taguchi methods to infrared window design

NASA Astrophysics Data System (ADS)

Osmer, Kurt A.; Pruszynski, Charles J.

1990-10-01

Dr. Genichi Taguchi, a prominent quality consultant, reduced a branch of statistics known as "Design of Experiments" to a cookbook methodology that can be employed by any competent engineer. This technique has been extensively employed by Japanese manufacturers, and is widely credited with helping them attain their current level of success in low cost, high quality product design and fabrication. Although this technique was originally put forth as a tool to streamline the determination of improved production processes, it can also be applied to a wide range of engineering problems. As part of an internal research project, this method of experimental design has been adapted to window trade studies and materials research. Two of these analyses are presented herein, and have been chosen to illustrate the breadth of applications to which the Taguchi method can be utilized.

Microbial quality of improved drinking water sources: evidence from western Kenya and southern Vietnam.

PubMed

Grady, Caitlin A; Kipkorir, Emmanuel C; Nguyen, Kien; Blatchley, E R

2015-06-01

In recent decades, more than 2 billion people have gained access to improved drinking water sources thanks to extensive effort from governments, and public and private sector entities. Despite this progress, many water sector development interventions do not provide access to safe water or fail to be sustained for long-term use. The authors examined drinking water quality of previously implemented water improvement projects in three communities in western Kenya and three communities in southern Vietnam. The cross-sectional study of 219 households included measurements of viable Escherichia coli. High rates of E. coli prevalence in these improved water sources were found in many of the samples. These findings suggest that measures above and beyond the traditional 'improved source' definition may be necessary to ensure truly safe water throughout these regions.

AHRQ series on complex intervention systematic reviews-paper 6: PRISMA-CI extension statement and checklist.

PubMed

Guise, Jeanne-Marie; Butler, Mary E; Chang, Christine; Viswanathan, Meera; Pigott, Terri; Tugwell, Peter

2017-10-01

Complex interventions are widely used in health systems, public health, education, and communities and are increasingly the subject of systematic reviews. Oversimplification and inconsistencies in reporting about complex interventions can limit the usability of review findings. Although guidance exists to ensure that reports of individual studies and systematic reviews adhere to accepted scientific standards, their design-specific focus leaves important reporting gaps relative to complex interventions in health care. This paper provides a stand-alone extension to the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) reporting tool for complex interventions-PRISMA-CI-to help authors, publishers, and readers understand and apply to systematic reviews of complex interventions. PRISMA-CI development followed the Enhancing the QUAlity and Transparency Of health Research Network guidance for extensions and focused on adding or modifying only essential items that are truly unique to complex interventions and are not covered by broader interpretation of current PRISMA guidance. PRISMA-CI provides an important structure and guidance for systematic reviews and meta-analyses for the highly prevalent and dynamic field of complex interventions. Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.

Effects of an Alpine Ski Resort on Hydrology and Water Quality in the Northeastern U.S.: Preliminary Findings from a Field Study

NASA Astrophysics Data System (ADS)

Wemple, B.; Shanley, J.; Denner, J.

2002-12-01

High elevation, forested watersheds are particularly vulnerable to stresses from development. Steep slopes and thin soils rapidly transmit water, nutrients and sediment when disturbed by logging, road construction or other activities associated with development. The effects of forest harvesting practices on streamflow and water quality in high-elevation, forested watersheds have been well studied and provide relevant information about the susceptibility of these ecosystems to anthropogenic disturbance. Few studies have directly addressed the hydrologic or water quality effects of ski resort development on mountain streams, and these studies draw almost entirely from western U.S. examples. Ski resorts in the eastern U.S. face particular development pressures. Transient and unpredictable snow conditions generate extensive need for snowmaking. Competitive economic pressure has motivated plans for slope-side village development and summer recreation facilities at many eastern U.S. ski resorts. Here, we report preliminary findings of a recently initiated paired-watershed study to examine the effects of alpine ski area development on water quantity and quality. Our study area is located on the eastern slope of Mt. Mansfield, Vermont, and includes the basins of Ranch Brook (9.6 sq km) and West Branch (11.7 sq km). Ranch Brook is undeveloped, except for a network of cross-country ski trails and unsurfaced access roads, and serves as our control watershed. West Branch encompasses nearly an entire major ski resort, with an extensive network of alpine ski lifts and trails, day lodges, snowmaking facilities, and vacation homes. A major expansion of resort facilities and ski trails has recently received state approval. Our preliminary analysis indicates distinct differences in runoff and water quality between the two basins. Differences in basin hydrographs suggest that ski trails alter the timing and magnitude of runoff, particularly during spring snowmelt. Elevated concentrations of total suspended solids in West Branch streamwater suggest that exposed surfaces (trails, parking lots) may be important sources of sediment in the ski resort basin. Streamwater chemistry at West Branch also suggests contamination by deicing salts. Variability in summer low flows between the two basins indicates unexplained differences in precipitation capture or groundwater loss in the basins and must be resolved in future analysis. These findings provide important baseline information for ski area management in the eastern U.S., where field studies have been sparse. Our future plans include hydrologic modeling to assess the effects of current development and various future development scenarios on streamflow and water quality.

Container-grown longleaf pine seedling quality

Treesearch

Mark J. Hainds; James P. Barnett

2006-01-01

The Longleaf Alliance, in cooperation with the USDA Forest Service, the Georgia Forestry Commission, and the Clemson Extension Service, has installed numerous longleaf pine (Pinus palustris Mill.) seedling quality studies across the Southeastern United States. This paper reviews survival and growth for different classes of container-grown longleaf...

Equity Sensitivity in Illinois Public School Teachers

ERIC Educational Resources Information Center

Grossi, Robert G.

2013-01-01

Research supports the importance of teacher quality on effective student learning. School districts recognize this fact and focus extensively on hiring quality teachers and improving teaching skills through professional development programs. Amazingly, despite common sense and a vast amount of research that reflects that employee performance is a…

Effect of testing for cancer on cancer- and venous thromboembolism (VTE)-related mortality and morbidity in people with unprovoked VTE.

PubMed

Robertson, Lindsay; Yeoh, Su Ern; Stansby, Gerard; Agarwal, Roshan

2017-08-23

Venous thromboembolism (VTE) is a collective term for two conditions: deep vein thrombosis (DVT) and pulmonary embolism (PE). A proportion of people with VTE have no underlying or immediately predisposing risk factors and the VTE is referred to as unprovoked. Unprovoked VTE can often be the first clinical manifestation of an underlying malignancy. This has raised the question of whether people with an unprovoked VTE should be investigated for an underlying cancer. Treatment for VTE is different in cancer and non-cancer patients and a correct diagnosis would ensure that people received the optimal treatment for VTE to prevent recurrence and further morbidity. Furthermore, an appropriate cancer diagnosis at an earlier, potentially curative stage could avoid the risk of cancer progression and thus lead to improvements in cancer-related mortality and morbidity. This is an update of a review first published in 2015. To determine whether testing for undiagnosed cancer in people with a first episode of unprovoked VTE (DVT of the lower limb or PE) is effective in reducing cancer and VTE-related mortality and morbidity and to determine which tests for cancer are best at identifying treatable cancers early. For this update, the Cochrane Vascular Information Specialist (CIS) searched the Specialised Register (16 February 2017). In addition, the CIS searched the Cochrane Register of Studies CENTRAL (2017, Issue 1). We searched trials registries (February 2017) and checked the reference lists of relevant articles. Randomised and quasi-randomised trials in which people with an unprovoked VTE were allocated to receive specific tests for cancer or clinically indicated tests only were eligible for inclusion in this review. Primary outcomes included all-cause mortality, cancer-related mortality and VTE-related mortality. Two review authors independently selected studies, assessed quality and extracted data. We resolved any disagreements by discussion. Four studies with 1644 participants met the inclusion criteria (two studies in the original review and two in this update). Two studies assessed the effect of extensive tests versus tests at the physician's discretion) while the other two studies assessed the effect of standard testing plus positron emission tomography (PET)/computed tomography (CT) scanning versus standard testing alone. For extensive tests versus tests at the physician's discretion, the quality of the evidence was low due to risk of bias (early termination of the studies). When comparing standard testing plus PET/CT scanning versus standard testing alone, the quality of evidence was moderate due to a risk of detection bias. The quality of the evidence was downgraded further when detection bias was present in one study with a low number of events.When comparing extensive tests versus tests at the physician's discretion, pooled analysis on two studies showed that testing for cancer was consistent with either a benefit or no benefit on cancer-related mortality (odds ratio (OR) 0.49, 95% confidence interval (CI) 0.15 to 1.67; 396 participants; 2 studies; P = 0.26; low quality evidence). One study (201 participants) showed that, overall, malignancies were less advanced in extensively tested participants than in participants in the control group. In total, 9/13 participants diagnosed with cancer in the extensively tested group had a T1 or T2 stage malignancy compared to 2/10 participants diagnosed with cancer in the control group (OR 5.00, 95% CI 1.05 to 23.76; P = 0.04; low quality evidence). There was no clear difference in detection of advanced stages between extensive tests versus tests at the physician's discretion: one participant in the extensively tested group had stage T3 compared with four participants in the control group (OR 0.25, 95% CI 0.03 to 2.28; P = 0.22; low quality evidence). In addition, extensively tested participants were diagnosed earlier than control group (mean: 1 month with extensive tests versus 11.6 months with tests at physician's discretion to cancer diagnosis from the time of diagnosis of VTE). Extensive testing did not increase the frequency of an underlying cancer diagnosis (OR 1.32, 95% CI 0.59 to 2.93; 396 participants; 2 studies; P = 0.50; low quality evidence). Neither study measured all-cause mortality, VTE-related morbidity and mortality, complications of anticoagulation, adverse effects of cancer tests, participant satisfaction or quality of life.When comparing standard testing plus PET/CT screening versus standard testing alone, standard testing plus PET/CT screening was consistent with either a benefit or no benefit on all-cause mortality (OR 1.22, 95% CI 0.49 to 3.04; 1248 participants; 2 studies; P = 0.66; moderate quality evidence), cancer-related mortality (OR 0.55, 95% CI 0.20 to 1.52; 1248 participants; 2 studies; P = 0.25; moderate quality evidence) or VTE-related morbidity (OR 1.02, 95% CI 0.48 to 2.17; 854 participants; 1 study; P = 0.96; moderate quality evidence). With regards to stage of cancer, there was no clear difference for detection of early (OR 1.78, 95% 0.51 to 6.17; 394 participants; 1 study; P = 0.37; low quality evidence) or advanced (OR 1.00, 95% CI 0.14 to 7.17; 394 participants; 1 study; P = 1.00; low quality evidence) stages of cancer. There was also no clear difference in the frequency of an underlying cancer diagnosis (OR 1.71, 95% CI 0.91 to 3.20; 1248 participants; 2 studies; P = 0.09; moderate quality evidence). Time to cancer diagnosis was 4.2 months in the standard testing group and 4.0 months in the standard testing plus PET/CT group (P = 0.88). Neither study measured VTE-related mortality, complications of anticoagulation, adverse effects of cancer tests, participant satisfaction or quality of life. Testing for cancer in people with unprovoked VTE may lead to earlier diagnosis of cancer at an earlier stage of the disease. However, there is currently insufficient evidence to draw definitive conclusions concerning the effectiveness of testing for undiagnosed cancer in people with a first episode of unprovoked VTE (DVT or PE) in reducing cancer and VTE-related morbidity and mortality. The results could be consistent with either benefit or no benefit. Further good-quality large-scale randomised controlled trials are required before firm conclusions can be made.

Leisure and Quality of Life in an International and Multicultural Context: What Are Major Pathways Linking Leisure to Quality of Life?

ERIC Educational Resources Information Center

Iwasaki, Yoshitaka

2007-01-01

This paper aims at advancing the conceptualization of leisure as a contributor to quality of life (QOL) in an international and multicultural context, based on an extensive and critical review of literature on leisure and QOL from a global, international perspective. Given the central role of culture in conceptualizing this notion, this paper…

High Quality, Low Cost Bulk Gallium Nitride Substrates Grown by the Electrochemical Solution Growth Method

DOE Office of Scientific and Technical Information (OSTI.GOV)

Seacrist, Michael

The objective of this project was to develop the Electrochemical Solution Growth (ESG) method conceived / patented at Sandia National Laboratory into a commercially viable bulk gallium nitride (GaN) growth process that can be scaled to low cost, high quality, and large area GaN wafer substrate manufacturing. The goal was to advance the ESG growth technology by demonstrating rotating seed growth at the lab scale and then transitioning process to prototype commercial system, while validating the GaN material and electronic / optical device quality. The desired outcome of the project is a prototype commercial process for US-based manufacturing of highmore » quality, large area, and lower cost GaN substrates that can drive widespread deployment of energy efficient GaN-based power electronic and optical devices. In year 1 of the project (Sept 2012 – Dec 2013) the overall objective was to demonstrate crystalline GaN growth > 100um on a GaN seed crystal. The development plan included tasks to demonstrate and implement a method for purifying reagent grade salts, develop the reactor 1 process for rotating seed Electrochemical Solution Growth (ESG) of GaN, grow and characterize ESG GaN films, develop a fluid flow and reaction chemistry model for GaN film growth, and design / build an improved growth reactor capable of scaling to 50mm seed diameter. The first year’s project objectives were met in some task areas including salt purification, film characterization, modeling, and reactor 2 design / fabrication. However, the key project objective of the growth of a crystalline GaN film on the seed template was not achieved. Amorphous film growth on the order of a few tenths of a micron has been detected with a film composition including Ga and N, plus several other impurities originating from the process solution and hardware. The presence of these impurities, particularly the oxygen, has inhibited the demonstration of crystalline GaN film growth on the seed template. However, the presence of both Ga and N at the growth surface indicates that the reactor hardware physics is all functioning properly; achieving film growth is a matter of controlling the chemistry at the interface. The impurities originating from the hardware are expected to be straightforward to eliminate. Activities were defined for an extension of budget period 1 to eliminate the undesired impurities originating from the reactor hardware and interfering with crystalline GaN film growth. The budget period 1 extension was negotiated during the 1st half of 2014. The budget period 1 extension spanned approximately from August 2014 to August 2015. The project objective for this extension period was to demonstrate at least 0.5um crystalline GaN film on a GaN seed in the lab scale reactor. The focus of the budget 1 extension period from August 2014 to August 2015 was to eliminate oxygen contamination interference with GaN film growth. The team procured the highest purity lowest oxygen salt for testing. Low oxygen crucible materials such as silicon carbide were installed and evaluated in the laboratory reactor. Growth experiments were performed with high purity salt, high purity hardware, and optimized oxide removal from the seed surface. Experiments were characterized with methods including UV inspection, profilometry, x-ray diffraction (XRD) to determine crystalline structure, optical and scanning electron microscopy, photoluminescence, x-ray photon spectroscopy (XPS), transmission electron microscopy (TEM), and secondary ion mass spectroscopy (SIMS). Despite successfully integrating the low oxygen materials in the laboratory reactor, the goal of depositing 0.5um of crystalline GaN on the MOCVD GaN seed was not met. Very thin (ca. 10nm) cubic phase GaN deposition was observed on the hexagonal MOCVD GaN seeds. But there was a competing etching reaction which was also observed and thought to be related to the presence of metallic lithium, a byproduct of the LiCl-KCl salt used as the process medium. The etching reaction could potentially be addressed by alternate salts not containing lithium, but would necessitate starting all over on the reactor and process design. Further, controlling the reaction of Ga and N in the bulk salt to favor deposition on the seed has proved to be very difficult and unlikely to be solved within the scope of this project in a manner consistent with the original objective for wafer or crystal scale thickness for GaN deposition on a GaN seed. Upon completion of the budget 1 extension period in August 2015 the project partners and DOE agreed to stop work on the project.« less

Influence of extensive compressed natural gas (CNG) usage on air quality

NASA Astrophysics Data System (ADS)

Suthawaree, Jeeranut; Sikder, Helena Akhter; Jones, Charlotte Emily; Kato, Shungo; Kunimi, Hitoshi; Mohammed Hamidul Kabir, Abu Naser; Kajii, Yoshizumi

2012-07-01

Compressed Natural Gas (CNG) is an inexpensive, indigenous energy resource which currently accounts for the majority of automobile and domestic energy consumption in Bangladesh. This extensive CNG usage, particularly within the capital city, Dhaka, heavily influences the atmospheric composition (and hence air quality), yet to date measurements of trace gases in regions dominated by CNG emissions are relatively limited. Here we report continuous observations of the atmospherically important trace gases O3, CO, SO2, NOx and volatile organic compounds (VOC), in ambient air in Dhaka City, Bangladesh, during May 2011. The average mixing ratios of O3, CO, SO2, and NOx for the measurement period were 18.9, 520.9, 7.6 and 21.5 ppbv, respectively. The ratios of CO to NO reveal that emissions from gasoline and CNG-fuelled vehicles were dominant during the daytime (slope of ˜26), while in contrast, owing to restrictions imposed on diesel fuelled vehicles entering Dhaka City, emissions from these vehicles only became significant during the night (slope of ˜10). The total VOC mixing ratio in Dhaka was ˜5-10 times higher than the levels reported in more developed Asian cities such as Tokyo and Bangkok, which consequently gives rise to a higher ozone formation potential (OFP). However, the most abundant VOC in Dhaka were the relatively long-lived ethane and propane (with mean mixing ratios of ˜115 and ˜30 ppbv, respectively), and as a consequence, the ozone formation potential per ppb carbon (ppbC) was lower in Dhaka than in Tokyo and Bangkok. Thus the atmospheric composition of air influenced by extensive CNG combustion may be characterized by high VOC mixing ratios, yet mixing ratios of the photochemical pollutant ozone do not drastically exceed the levels typical of Asian cities with considerably lower VOC levels.

Reliability of muscle strength assessment in chronic post-stroke hemiparesis: a systematic review and meta-analysis.

PubMed

Rabelo, Michelle; Nunes, Guilherme S; da Costa Amante, Natália Menezes; de Noronha, Marcos; Fachin-Martins, Emerson

2016-02-01

Muscle weakness is the main cause of motor impairment among stroke survivors and is associated with reduced peak muscle torque. To systematically investigate and organize the evidence of the reliability of muscle strength evaluation measures in post-stroke survivors with chronic hemiparesis. Two assessors independently searched four electronic databases in January 2014 (Medline, Scielo, CINAHL, Embase). Inclusion criteria comprised studies on reliability on muscle strength assessment in adult post-stroke patients with chronic hemiparesis. We extracted outcomes from included studies about reliability data, measured by intraclass correlation coefficient (ICC) and/or similar. The meta-analyses were conducted only with isokinetic data. Of 450 articles, eight articles were included for this review. After quality analysis, two studies were considered of high quality. Five different joints were analyzed within the included studies (knee, hip, ankle, shoulder, and elbow). Their reliability results varying from low to very high reliability (ICCs from 0.48 to 0.99). Results of meta-analysis for knee extension varying from high to very high reliability (pooled ICCs from 0.89 to 0.97), for knee flexion varying from high to very high reliability (pooled ICCs from 0.84 to 0.91) and for ankle plantar flexion showed high reliability (pooled ICC = 0.85). Objective muscle strength assessment can be reliably used in lower and upper extremities in post-stroke patients with chronic hemiparesis.

The High Level Data Reduction Library

NASA Astrophysics Data System (ADS)

Ballester, P.; Gabasch, A.; Jung, Y.; Modigliani, A.; Taylor, J.; Coccato, L.; Freudling, W.; Neeser, M.; Marchetti, E.

2015-09-01

The European Southern Observatory (ESO) provides pipelines to reduce data for most of the instruments at its Very Large telescope (VLT). These pipelines are written as part of the development of VLT instruments, and are used both in the ESO's operational environment and by science users who receive VLT data. All the pipelines are highly specific geared toward instruments. However, experience showed that the independently developed pipelines include significant overlap, duplication and slight variations of similar algorithms. In order to reduce the cost of development, verification and maintenance of ESO pipelines, and at the same time improve the scientific quality of pipelines data products, ESO decided to develop a limited set of versatile high-level scientific functions that are to be used in all future pipelines. The routines are provided by the High-level Data Reduction Library (HDRL). To reach this goal, we first compare several candidate algorithms and verify them during a prototype phase using data sets from several instruments. Once the best algorithm and error model have been chosen, we start a design and implementation phase. The coding of HDRL is done in plain C and using the Common Pipeline Library (CPL) functionality. HDRL adopts consistent function naming conventions and a well defined API to minimise future maintenance costs, implements error propagation, uses pixel quality information, employs OpenMP to take advantage of multi-core processors, and is verified with extensive unit and regression tests. This poster describes the status of the project and the lesson learned during the development of reusable code implementing algorithms of high scientific quality.

Three Soil Quality Demonstrations for Educating Extension Clientele

ERIC Educational Resources Information Center

Hoorman, James J.

2014-01-01

There is a renewed interest in educating youth, Master Gardeners, and agricultural producers about soil quality. Three soil demonstrations show how soil organic matter increases water holding capacity, improves soil structure, and increases nutrient retention. Exercise one uses clay bricks and sponges to represent mineral soils and soil organic…

Using Value-Added Measures of Teacher Quality. Brief 9

ERIC Educational Resources Information Center

Hanushek, Eric A.; Rivkin, Steven G.

2010-01-01

Extensive education research on the contribution of teachers to student achievement produces two generally accepted results. First, teacher quality varies substantially as measured by the value added to student achievement or future academic attainment or earnings. Second, variables often used to determine entry into the profession and…

Centre-Based Child Care Quality in Urban Australia

ERIC Educational Resources Information Center

Ishimine, Karin; Wilson, Rachel

2009-01-01

This study investigates the quality of childcare centres in urban Australian communities designated according to different bands of Centre Location Demographics (CLD). Childcare centres were assessed using the Early Childhood Environment Rating Scale- Revised Edition (ECERS-R) and the Early Childhood Environment Rating Scale-Extension (ECERS-E).…

76 FR 31339 - Agency Information Collection Activities: Submission for OMB Review; Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-31

... extension of the currently approved tool for the collection of ambulatory care clinical performance measure...: Medicare Demonstration Ambulatory Care Quality Measure Performance Assessment Tool (``PAT''); Use: This... based system. This system will also provide a platform for developing tools to collect clinical quality...

Raising the Bar on Faculty Productivity: Realigning Performance Standards to Enhance Quality Trajectories

ERIC Educational Resources Information Center

Hardré, Patricia L.

2014-01-01

Many universities have observed needs and shared goals that include increasing faculty members' research productivity (in quantity or quality). Strategies for raising faculty performance include revising standards and supporting valued outcomes with rewards and incentives. One college at a research-extensive university received institutional…

Can Host Plant Resistance Protect the Quality of Wheat from Fusarium Head Blight?

USDA-ARS?s Scientific Manuscript database

Fusarium head blight (FHB) infection reduces the amount of millable grain from an infected field, reduces mill yields, and generally degrades end-use quality. In 2009, the Logan County, KY, wheat trial had extended conditions for infection with FHB resulting in extensive and uniform infection withi...

Assessment of air quality impact of a proposed section of Interstate 66.

DOT National Transportation Integrated Search

1972-01-01

This report presents an assessment of the impact of a proposed section of Interstate 66 on the quality of the air in the immediate area of the project and in adjacent areas. The proposed project begins with an extension of existing I-66 at the interc...

The Effects of Sleep Extension on Sleep, Performance, Immunity and Physical Stress in Rugby Players.

PubMed

Swinbourne, Richard; Miller, Joanna; Smart, Daniel; Dulson, Deborah K; Gill, Nicholas

2018-05-10

(1) Background: The purpose of the present study was to examine the efficacy of sleep extension in professional rugby players. The aims were to: (i) characterise sleep quantity in elite rugby players and determine changes in immune function and stress hormone secretion during a pre-season training programme; (ii) evaluate the efficacy of a sleep extension intervention in improving sleep, markers of physical stress, immune function and performance. (2) Methods: Twenty five highly trained athletes from a professional rugby team (age (mean ± SD) 25 ± 2.7 years; height 1.87 ± 0.07 m; weight 105 ± 12.1 kg) participated in a six week pre-post control-trial intervention study. Variables of sleep, immune function, sympathetic nervous activity, physiological stress and reaction times were measured. (3) Results: Sleep extension resulted in a moderate improvement in sleep quality scores ([mean; ± 90% confidence limits] −24.8%; ± 54.1%) and small to moderate increases in total sleep time (6.3%; ± 6.3%) and time in bed (7.3%; ± 3.6%). In addition, a small decrease in cortisol (−18.7%; ± 26.4%) and mean reaction times (−4.3%; ± 3.1%) was observed following the intervention, compared to the control. (4) Conclusions: Professional rugby players are at risk of poor sleep during pre-season training, with concomitant rises in physical stress. Implementing a sleep extension programme among professional athletes is recommended to improve sleep, with beneficial changes in stress hormone expression and reaction time performance.

Application of high pressure processing for shelf life extension of litchi fruits (Litchi chinensis cv. Bombai) during refrigerated storage.

PubMed

Kaushik, Neelima; Kaur, Barjinder P; Rao, P Srinivasa

2014-10-01

This study attempts to report the effect of high pressure processing (100, 200 and 300 MPa for 5, 10 and 15 min at 27 ± 2 ℃) on quality and shelf life extension of 'Bombai' variety peeled litchi fruits during refrigerated storage (5 ℃). High pressure processing significantly increased total colour difference, browning index, drip loss and total soluble solids, whereas pH decreased after processing. Also, ascorbic acid content significantly decreased after high pressure processing and retention of 83.5% was observed. Texture profile analysis showed that pressurization significantly affected firmness and increased cohesiveness, gumminess, springiness and chewiness of litchi fruits. Pressure-induced firming effect was observed at 100 and 200 MPa pressure. A maximum of 3.29, 3.24 and 3.77 log10 cycles reduction in aerobic mesophiles, yeast & mold and psychrotrophs count, respectively, was achieved after pressurization of 300 MPa for 10 and 15 min treatments. During storage, samples treated at 300 MPa for 10 and 15 min showed relatively minimal changes in physico-chemical attributes, textural parameters and maintained lower viable microbial counts. Treatments at 300 MPa for 10 min and 15 min were found to enhance the shelf life of litchi fruits up to 32 days as compared to 12 days of untreated during refrigerated storage (5 ℃). © The Author(s) 2013 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.

HOKF: High Order Kalman Filter for Epilepsy Forecasting Modeling.

PubMed

Nguyen, Ngoc Anh Thi; Yang, Hyung-Jeong; Kim, Sunhee

2017-08-01

Epilepsy forecasting has been extensively studied using high-order time series obtained from scalp-recorded electroencephalography (EEG). An accurate seizure prediction system would not only help significantly improve patients' quality of life, but would also facilitate new therapeutic strategies to manage epilepsy. This paper thus proposes an improved Kalman Filter (KF) algorithm to mine seizure forecasts from neural activity by modeling three properties in the high-order EEG time series: noise, temporal smoothness, and tensor structure. The proposed High-Order Kalman Filter (HOKF) is an extension of the standard Kalman filter, for which higher-order modeling is limited. The efficient dynamic of HOKF system preserves the tensor structure of the observations and latent states. As such, the proposed method offers two main advantages: (i) effectiveness with HOKF results in hidden variables that capture major evolving trends suitable to predict neural activity, even in the presence of missing values; and (ii) scalability in that the wall clock time of the HOKF is linear with respect to the number of time-slices of the sequence. The HOKF algorithm is examined in terms of its effectiveness and scalability by conducting forecasting and scalability experiments with a real epilepsy EEG dataset. The results of the simulation demonstrate the superiority of the proposed method over the original Kalman Filter and other existing methods. Copyright © 2017 Elsevier B.V. All rights reserved.

SSR_pipeline--computer software for the identification of microsatellite sequences from paired-end Illumina high-throughput DNA sequence data

USGS Publications Warehouse

Miller, Mark P.; Knaus, Brian J.; Mullins, Thomas D.; Haig, Susan M.

2013-01-01

SSR_pipeline is a flexible set of programs designed to efficiently identify simple sequence repeats (SSRs; for example, microsatellites) from paired-end high-throughput Illumina DNA sequencing data. The program suite contains three analysis modules along with a fourth control module that can be used to automate analyses of large volumes of data. The modules are used to (1) identify the subset of paired-end sequences that pass quality standards, (2) align paired-end reads into a single composite DNA sequence, and (3) identify sequences that possess microsatellites conforming to user specified parameters. Each of the three separate analysis modules also can be used independently to provide greater flexibility or to work with FASTQ or FASTA files generated from other sequencing platforms (Roche 454, Ion Torrent, etc). All modules are implemented in the Python programming language and can therefore be used from nearly any computer operating system (Linux, Macintosh, Windows). The program suite relies on a compiled Python extension module to perform paired-end alignments. Instructions for compiling the extension from source code are provided in the documentation. Users who do not have Python installed on their computers or who do not have the ability to compile software also may choose to download packaged executable files. These files include all Python scripts, a copy of the compiled extension module, and a minimal installation of Python in a single binary executable. See program documentation for more information.

The Effects of Sleep Restriction and Extension on School-Age Children: What a Difference an Hour Makes.

ERIC Educational Resources Information Center

Sadeh, Avi; Gruber, Reut; Raviv, Amiram

2003-01-01

Assessed effects of sleep restriction and extension on 9- to 12-year-olds' neurobehavioral functioning. Found that modest sleep restriction led to improved sleep quality but to reduced reported alertness. Children who extended sleep improved significantly from baseline their performance on the digit forward memory test and reaction time on the…

Using Public Opinions of Water Quality to Provide Direction for Extension

ERIC Educational Resources Information Center

Kopiyawattage, Kumudu P. P.; Lamm, Alexa J.

2017-01-01

Extension educators can help the public learn about critical issues that contribute to existing problems in communities. Water is just such an issue in Florida--in fact, water is the top issue in Florida. The purpose of the study reported in this article was to identify Florida residents' opinions about clean water and their preferred modes of…

Extensions to the Beta Secondary Standard BSS 2

NASA Astrophysics Data System (ADS)

Behrens, R.; Buchholz, G.

2011-11-01

Since several years, the irradiation facility for beta radiation, the Beta Secondary Standard BSS 2 developed at PTB, has been in worldwide use for the performance of irradiations with calibrated beta sources. Due to recent developments in eye tumor therapy, in eye lens dosimetry, and in soft- and hardware technology, several extensions have been added to the BSS 2. These extensions are described in this paper: 1. The possibility of using a 106Ru/106Rh beta source was added as this radionuclide is often used in tumor therapy. 2. The (small) contribution due to photon radiation was included in the dose (rate) reported by the BSS 2, as this was missing in the past. 3. The quantity personal dose equivalent at a depth of 3 mm, Hp(3), was implemented due to recent findings on the radio sensitivity of the eye lens regarding cataract induction and the subsequent lowering of the dose limit from 150 mSv down to 20 mSv per year; 4. The correction for ambient conditions (air temperature, pressure, and relative humidity) was improved in order to adequately handle the quantity Hp(3) and in order to extend the range of use beyond 25°C. 5. A checksum test was added to the software to secure the calibration data against (un)intended changes. 6. The connection of the PC and the BSS 2 has been changed to a network interface (TCP/IP) in order to be able to use up-to-date computers not containing a parallel and a serial port. 7. A rod phantom was added in order to make sure the mechanical set-up is of high quality. All these extensions have been implemented in the PTB's BSS 2 model. The routine implementation of extension 1 is still under investigation by the manufacturer. The commercially available BSS 2 will contain extensions 2 to 6 starting approximately in 2012, while extension 7 has already been incorporated since 2011. Extensions 2 to 4 will also be available for old BSS 2 versions via a software update, starting approximately at the beginning of 2012. Extension 6 will be available via hardware change by the manufacturer.

PRISMA-Children (C) and PRISMA-Protocol for Children (P-C) Extensions: a study protocol for the development of guidelines for the conduct and reporting of systematic reviews and meta-analyses of newborn and child health research.

PubMed

Kapadia, Mufiza Z; Askie, Lisa; Hartling, Lisa; Contopoulos-Ioannidis, Despina; Bhutta, Zulfiqar A; Soll, Roger; Moher, David; Offringa, Martin

2016-04-18

Paediatric systematic reviews differ from adult systematic reviews in several key aspects such as considerations of child tailored interventions, justifiable comparators, valid outcomes and child sensitive search strategies. Available guidelines, including PRISMA-P (2015) and PRISMA (2009), do not cover all the complexities associated with reporting systematic reviews in the paediatric population. Using a collaborative, multidisciplinary structure, we aim to develop evidence-based and consensus-based PRISMA-P-C (Protocol for Children) and PRISMA-C (Children) Extensions to guide paediatric systematic review protocol and completed review reporting. This project's methodology follows published recommendations for developing reporting guidelines and involves the following six phases; (1) establishment of a steering committee representing key stakeholder groups; (2) a scoping review to identify potential Extension items; (3) three types of consensus activities including meetings of the steering committee to achieve high-level decisions on the content and methodology of the Extensions, a survey of key stakeholders to generate a list of possible items to include in the Extensions and a formal consensus meeting to select the reporting items to add to, or modify for, the Extension; (4) the preliminary checklist items generated in phase III will be evaluated against the existing evidence and reporting practices in paediatric systematic reviews; (5) extension statements and explanation and elaboration documents will provide detailed advice for each item and examples of good reporting; (6) development and implementation of effective knowledge translation of the extension checklist, and an evaluation of the Extensions by key stakeholders. This protocol was considered a quality improvement project by the Hospital for Sick Children's Ethics Committee and did not require ethical review. The resultant checklists, jointly developed with all relevant stakeholders, will be disseminated through peer-reviewed journals as well as national and international conference presentations. Endorsement of the checklist will be sought simultaneously in multiple journals. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

PRISMA-Children (C) and PRISMA-Protocol for Children (P-C) Extensions: a study protocol for the development of guidelines for the conduct and reporting of systematic reviews and meta-analyses of newborn and child health research

PubMed Central

Kapadia, Mufiza Z; Askie, Lisa; Hartling, Lisa; Contopoulos-Ioannidis, Despina; Bhutta, Zulfiqar A; Soll, Roger; Moher, David; Offringa, Martin

2016-01-01

Introduction Paediatric systematic reviews differ from adult systematic reviews in several key aspects such as considerations of child tailored interventions, justifiable comparators, valid outcomes and child sensitive search strategies. Available guidelines, including PRISMA-P (2015) and PRISMA (2009), do not cover all the complexities associated with reporting systematic reviews in the paediatric population. Using a collaborative, multidisciplinary structure, we aim to develop evidence-based and consensus-based PRISMA-P-C (Protocol for Children) and PRISMA-C (Children) Extensions to guide paediatric systematic review protocol and completed review reporting. Methods and analysis This project's methodology follows published recommendations for developing reporting guidelines and involves the following six phases; (1) establishment of a steering committee representing key stakeholder groups; (2) a scoping review to identify potential Extension items; (3) three types of consensus activities including meetings of the steering committee to achieve high-level decisions on the content and methodology of the Extensions, a survey of key stakeholders to generate a list of possible items to include in the Extensions and a formal consensus meeting to select the reporting items to add to, or modify for, the Extension; (4) the preliminary checklist items generated in phase III will be evaluated against the existing evidence and reporting practices in paediatric systematic reviews; (5) extension statements and explanation and elaboration documents will provide detailed advice for each item and examples of good reporting; (6) development and implementation of effective knowledge translation of the extension checklist, and an evaluation of the Extensions by key stakeholders. Ethics and Dissemination This protocol was considered a quality improvement project by the Hospital for Sick Children's Ethics Committee and did not require ethical review. The resultant checklists, jointly developed with all relevant stakeholders, will be disseminated through peer-reviewed journals as well as national and international conference presentations. Endorsement of the checklist will be sought simultaneously in multiple journals. PMID:27091820

Wildland fire management and air quality in the southern Sierra Nevada: using the Lion Fire as a case study with a multi-year perspective on PM(2.5) impacts and fire policy.

PubMed

Schweizer, Don; Cisneros, Ricardo

2014-11-01

Management of fire is an important and controversial policy issue. Active fire suppression has led to a backlog of fuels, limited the ecological benefits of fire, and reduced short-term smoke impacts likely delaying these emissions to future generations over a larger spatial extent. Smoke impacts can be expected to increase as fire size and intensity increase and the fuel backlog is consumed; whether through reintroduction of fire under desirable conditions or through stand replacing fire. Land Management Agencies would like to increase the use of naturally ignited fires to burn during favorable conditions as a way to reduce catastrophic fires. This study provides information about the levels of air quality impacts expected from these types of fires and discusses some of the policy controversies of managed fire that propagate inconsistencies between agencies and enter the public discourse. The Lion Fire, a primarily low intensity 8,370 ha fire that was extensively monitored for Particulate Matter less than 2.5 microns (PM2.5), is used to quantify impacts to air quality. PM2.5 monitoring sites are used to assess exposure, public health impacts, and subsequently quantify annual air quality during a year with a fire that is within the historic normal fire size and intensity for this area. Ground level PM2.5 impacts were found to be localized with 99% of the hourly Air Quality Index readings in the moderate or good category for the sites impacted by the fire. PM2.5 concentrations at sites nearest the fire were below annual federal air quality standards for PM2.5 with annual 98th percentile at the most impacted sites (Johnsondale, Kernville, and Camp Nelson) of 35.0, 34.0, and 28.0 μg m(-3) respectively. Smoke impacts to PM2.5 concentrations were not found to reach the populated Central Valley. The findings suggest that this type of fire can be implemented with minimal public health impacts thus allowing an opportunity for air and fire managers to alter policy to allow additional burning in an area with severe anthropogenic air pollution and where frequent widespread fire is both beneficial and inevitable. The more extensive air quality impacts documented with large high intensity fire may be averted by embracing the use of fire to prevent unwanted high intensity burns. A widespread increase in the use of fire for ecological benefit may provide the resiliency needed in Sierra Nevada forests as well as be the most beneficial to public health through the reduction of single dose exposure to smoke and limiting impacts spatially. Copyright © 2014 Elsevier Ltd. All rights reserved.

Relationships among spinal mobility and sagittal alignment of spine and lower extremity to quality of life and risk of falls.

PubMed

Ishikawa, Yoshinori; Miyakoshi, Naohisa; Hongo, Michio; Kasukawa, Yuji; Kudo, Daisuke; Shimada, Yoichi

2017-03-01

Spinal deformities can affect quality of life (QOL) and risk of falling, but no studies have explored the relationships of spinal mobility and sagittal alignment of spine and the lower extremities simultaneously. Purpose of this study is to clarify the relationship of those postural parameters to QOL and risk of falling. The study evaluated 110 subjects (41 men, 69 women; mean age, 73 years). Upright and flexion and extension angles for thoracic kyphosis, lumbar lordosis, and spinal inclination were evaluated with SpinalMouse ® . Total-body inclination and hip and knee flexion angles in upright position were measured from lateral photographs. Subjects were divided into Fallers (n=23, 21%) and Non-fallers (n=87, 79%) based on past history of falls. QOL was assessed using the Short Form 36 Health Survey (SF-36 ® ). Age, total-body inclination, spinal inclination upright and in extension, thoracic kyphosis in flexion, lumbar lordosis upright and in extension, and knee flexion correlated significantly with the SF-36. Multiple regression analysis revealed total-body inclination and knee flexion to have the most significant relationships with the SF-36. SF-36, total-body inclination, spinal inclination in extension, thoracic kyphosis in flexion, lumbar lordosis upright and in extension, and hip and knee flexion angles differed significantly between Fallers and Non-fallers (P<0.05 for all). Multivariate logistic regression analyses revealed lumbar lordosis in extension to be a significant predictor of falling (P=0.038). Forward-stooped posture and knee-flexion deformity could be important indicator of lower QOL. Moreover, limited extension in the lumbar spine could be a useful screening examination for fall prevention in the elderly. Copyright © 2017 Elsevier B.V. All rights reserved.

Genetic Engineering of Alfalfa (Medicago sativa L.).

PubMed

Wang, Dan; Khurshid, Muhammad; Sun, Zhan Min; Tang, Yi Xiong; Zhou, Mei Liang; Wu, Yan Min

2016-01-01

Alfalfa is excellent perennial legume forage for its extensive ecological adaptability, high nutrition value, palatability and biological nitrogen fixation. It plays a very important role in the agriculture, animal husbandry and ecological construction. It is cultivated in all continents. With the development of modern plant breeding and genetic engineering techniques, a large amount of work has been carried out on alfalfa. Here we summarize the recent research advances in genetic engineering of alfalfa breeding, including transformation, quality improvement, stress resistance and as a bioreactor. The review article can enables us to understand the research method, direction and achievements of genetic engineering technology of Alfalfa.

A look at 15 years of planar thallium-201 imaging

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kaul, S.

1989-09-01

Extensive experience has been accumulated over the past 15 years regarding planar thallium-201 imaging. Quantitation of technically superior images provides a high sensitivity and specificity for the detection of CAD. In addition, planar thallium-201 images provide very important prognostic information in different clinical situations. Although single photon emission computerized tomography offers potential theoretical advantages over planar imaging, because of the problems involved in reconstruction, specifically the creation of artifacts, it may not be the ideal imaging modality in all situations. Good quality planar thallium-201 imaging still has an important role in clinical cardiology today. 144 references.

A method of object recognition for single pixel imaging

NASA Astrophysics Data System (ADS)

Li, Boxuan; Zhang, Wenwen

2018-01-01

Computational ghost imaging(CGI), utilizing a single-pixel detector, has been extensively used in many fields. However, in order to achieve a high-quality reconstructed image, a large number of iterations are needed, which limits the flexibility of using CGI in practical situations, especially in the field of object recognition. In this paper, we purpose a method utilizing the feature matching to identify the number objects. In the given system, approximately 90% of accuracy of recognition rates can be achieved, which provides a new idea for the application of single pixel imaging in the field of object recognition

Extension of expiration date for temporary pilot program setting the time and place for a hearing before an administrative law judge. Final rule.

PubMed

2014-07-18

We are extending for one year our pilot program that authorizes the agency to set the time and place for a hearing before an administrative law judge (ALJ). Extending the pilot program continues our commitment to improve the efficiency of our hearing process and provide accurate, high-quality decisions for claimants. The current pilot program will expire on August 9, 2014. In this final rule, we are extending the expiration date to August 10, 2015. We are making no other substantive changes.

The Disks of 48 Per and ψ Per

NASA Astrophysics Data System (ADS)

Grzenia, B. J.; Jones, C. E.; Tycner, C.; Sigut, T. A. A.

2016-11-01

The B-emission stars 48 Per (HD 25940, HR 1273) and ψ Per (HD 22192, HR 1087) share similar stellar parameters with their disks viewed near pole-on in the case of 48 Per, and near edge-on for ψ Per. An extensive set of high-quality interferometric observations were obtained for both stars between 2006 and 2011 with the Navy Precision Optical Interferometer (NPOI) in the Hα emitting region. Using a three-step modelling process, model visibilities are compared to observations with a view toward achieving better constraints on the disk models than were possible with previous studies.

High energy near- and far-field ptychographic tomography at the ESRF

NASA Astrophysics Data System (ADS)

da Silva, Julio C.; Haubrich, Jan; Requena, Guillermo; Hubert, Maxime; Pacureanu, Alexandra; Bloch, Leonid; Yang, Yang; Cloetens, Peter

2017-09-01

In high-resolution tomography, one needs high-resolved projections in order to reconstruct a high-quality 3D map of a sample. X-ray ptychography is a robust technique which can provide such high-resolution 2D projections taking advantage of coherent X-rays. This technique was used in the far-field regime for a fair amount of time, but it can now also be implemented in the near-field regime. In both regimes, the technique enables not only high-resolution imaging, but also high sensitivity to the electron density of the sample. The combination with tomography makes 3D imaging possible via ptychographic X-ray computed tomography (PXCT), which can provide a 3D map of the complex-valued refractive index of the sample. The extension of PXCT to X-ray energies above 15 keV is challenging, but it can allow the imaging of object opaque to lower energy. We present here the implementation and developments of high-energy near- and far-field PXCT at the ESRF.

Otitis Media, the Quality of Child Care, and the Social/Communicative Behavior of Toddlers: A Replication and Extension

ERIC Educational Resources Information Center

Vernon-Feagans, Lynne; Manlove, Elizabeth E.

2005-01-01

The purpose of this study was to examine the effects of otitis media (OM) and the quality of child care on the social and communicative behaviors of toddlers, using a cumulative risk framework that included moderation. The study followed 72 children who began child care in infancy. Both process and structural aspects of the quality of 11 child…

An Assessment of Gigabit Ethernet Technology and Its Applications at the NASA Glenn Research Center

NASA Technical Reports Server (NTRS)

Bakes, Catherine Murphy; Kim, Chan M.; Ramos, Calvin T.

2000-01-01

This paper describes Gigabit Ethernet and its role in supporting R&D programs at NASA Glenn. These programs require an advanced high-speed network capable of transporting multimedia traffic, including real-time visualization, high- resolution graphics, and scientific data. GigE is a 1 Gbps extension to 10 and 100 Mbps Ethernet. The IEEE 802.3z and 802.3ab standards define the MAC layer and 1000BASE-X and 1000BASE-T physical layer specifications for GigE. GigE switches and buffered distributors support IEEE 802.3x flow control. The paper also compares GigE with ATM in terms of quality of service, data rate, throughput, scalability, interoperability, network management, and cost of ownership.

Thermoelectric integrated membrane evaporation water recovery technology

NASA Technical Reports Server (NTRS)

Roebelen, G. J., Jr.; Winkler, H. E.; Dehner, G. F.

1982-01-01

The recently developed Thermoelectric Integrated Membrane Evaporation Subsystem (TIMES) offers a highly competitive approach to water recovery from waste fluids for future on-orbit stations such as the Space Operations Center. Low power, compactness and gravity insensitive operation are featured in this vacuum distillation subsystem that combines a hollow fiber membrane evaporator with a thermoelectric heat pump. The hollow fiber elements provide positive liquid/gas phase control with no moving parts other than pumps and an accumulator, thus solving problems inherent in other reclamation subsystem designs. In an extensive test program, over 850 hours of operation were accumulated during which time high quality product water was recovered from both urine and wash water at an average steady state production rate of 2.2 pounds per hour.

Xi-CAM v1.2.3

DOE Office of Scientific and Technical Information (OSTI.GOV)

PANDOLFI, RONALD; KUMAR, DINESH; VENKATAKRISHNAN, SINGANALLUR

Xi-CAM aims to provide a community driven platform for multimodal analysis in synchrotron science. The platform core provides a robust plugin infrastructure for extensibility, allowing continuing development to simply add further functionality. Current modules include tools for characterization with (GI)SAXS, Tomography, and XAS. This will continue to serve as a development base as algorithms for multimodal analysis develop. Seamless remote data access, visualization and analysis are key elements of Xi-CAM, and will become critical to synchrotron data infrastructure as expectations for future data volume and acquisition rates rise with continuously increasing throughputs. The highly interactive design elements of Xi-cam willmore » similarly support a generation of users which depend on immediate data quality feedback during high-throughput or burst acquisition modes.« less

SIRF: Simultaneous Satellite Image Registration and Fusion in a Unified Framework.

PubMed

Chen, Chen; Li, Yeqing; Liu, Wei; Huang, Junzhou

2015-11-01

In this paper, we propose a novel method for image fusion with a high-resolution panchromatic image and a low-resolution multispectral (Ms) image at the same geographical location. The fusion is formulated as a convex optimization problem which minimizes a linear combination of a least-squares fitting term and a dynamic gradient sparsity regularizer. The former is to preserve accurate spectral information of the Ms image, while the latter is to keep sharp edges of the high-resolution panchromatic image. We further propose to simultaneously register the two images during the fusing process, which is naturally achieved by virtue of the dynamic gradient sparsity property. An efficient algorithm is then devised to solve the optimization problem, accomplishing a linear computational complexity in the size of the output image in each iteration. We compare our method against six state-of-the-art image fusion methods on Ms image data sets from four satellites. Extensive experimental results demonstrate that the proposed method substantially outperforms the others in terms of both spatial and spectral qualities. We also show that our method can provide high-quality products from coarsely registered real-world IKONOS data sets. Finally, a MATLAB implementation is provided to facilitate future research.

A Spatial and Temporal Assessment of Non-Point Groundwater Pollution Sources, Tutuila Island, American Samoa

NASA Astrophysics Data System (ADS)

Shuler, C. K.; El-Kadi, A. I.; Dulaiova, H.; Glenn, C. R.; Fackrell, J.

2015-12-01

The quality of municipal groundwater supplies on Tutuila, the main island in American Samoa, is currently in question. A high vulnerability for contamination from surface activities has been recognized, and there exists a strong need to clearly identify anthropogenic sources of pollution and quantify their influence on the aquifer. This study examines spatial relationships and time series measurements of nutrients and other tracers to identify predominant pollution sources and determine the water quality impacts of the island's diverse land uses. Elevated groundwater nitrate concentrations are correlated with areas of human development, however, the mixture of residential and agricultural land use in this unique village based agrarian setting makes specific source identification difficult using traditional geospatial analysis. Spatial variation in anthropogenic impact was assessed by linking NO3- concentrations and δ15N(NO3) from an extensive groundwater survey to land-use types within well capture zones and groundwater flow-paths developed with MODFLOW, a numerical groundwater model. Land use types were obtained from high-resolution GIS data and compared to water quality results with multiple-regression analysis to quantify the impact that different land uses have on water quality. In addition, historical water quality data and new analyses of δD and δ18O in precipitation, groundwater, and mountain-front recharge waters were used to constrain the sources and mechanisms of contamination. Our analyses indicate that groundwater nutrient levels on Tutuila are controlled primarily by residential, not agricultural activity. Also a lack of temporal variation suggests that episodic pollution events are limited to individual water sources as opposed to the entire aquifer. These results are not only valuable for water quality management on Tutuila, but also provide insight into the sustainability of groundwater supplies on other islands with similar hydrogeology and land use history.

Gene expression and activity of digestive enzymes of Daphnia pulex in response to food quality differences.

PubMed

Schwarzenberger, Anke; Fink, Patrick

2018-04-01

Food quality is an important factor influencing organisms' well-being. In freshwater ecosystems, food quality has been studied extensively for the keystone herbivore genus Daphnia, as they form the critical trophic link between primary producers and higher order consumers such as fish. For Daphnia, the edible fraction of phytoplankton in lakes (consisting mostly of unicellular algae and cyanobacteria) is extraordinarily diverse. To be able to digest different food particles, Daphnia possess a set of digestive enzymes that metabolize carbohydrates, lipids and proteins. Recent studies have found a connection between gene expression and activity of single digestive enzyme types of Daphnia, i.e. lipases and proteases, and transcriptome studies have shown that a variety of genes coding for gut enzymes are differentially expressed in response to different food algae. However, never before has a set of digestive enzymes been studied simultaneously both on the gene expression and the enzyme activity level in Daphnia. Here, we investigated several digestive enzymes of Daphnia pulex in a comparison between a high-quality (green algal) and a low-quality (cyanobacterial) diet. Diet significantly affected the expression of all investigated digestive enzyme genes and enzyme activity was altered between treatments. Furthermore, we found that gene expression and enzyme activity were significantly correlated in cellulase, triacylglycerol lipase and β-glucosidase when switched from high to low-quality food. We conclude that one of the factors causing the often observed low biomass and energy transfer efficiency from cyanobacteria to Daphnia is probably the switch to a cost-effective overall increase of gene expression and activity of digestive enzymes of this herbivore. Copyright © 2018 Elsevier Inc. All rights reserved.

Fast Physically Correct Refocusing for Sparse Light Fields Using Block-Based Multi-Rate View Interpolation.

PubMed

Huang, Chao-Tsung; Wang, Yu-Wen; Huang, Li-Ren; Chin, Jui; Chen, Liang-Gee

2017-02-01

Digital refocusing has a tradeoff between complexity and quality when using sparsely sampled light fields for low-storage applications. In this paper, we propose a fast physically correct refocusing algorithm to address this issue in a twofold way. First, view interpolation is adopted to provide photorealistic quality at infocus-defocus hybrid boundaries. Regarding its conventional high complexity, we devised a fast line-scan method specifically for refocusing, and its 1D kernel can be 30× faster than the benchmark View Synthesis Reference Software (VSRS)-1D-Fast. Second, we propose a block-based multi-rate processing flow for accelerating purely infocused or defocused regions, and a further 3- 34× speedup can be achieved for high-resolution images. All candidate blocks of variable sizes can interpolate different numbers of rendered views and perform refocusing in different subsampled layers. To avoid visible aliasing and block artifacts, we determine these parameters and the simulated aperture filter through a localized filter response analysis using defocus blur statistics. The final quadtree block partitions are then optimized in terms of computation time. Extensive experimental results are provided to show superior refocusing quality and fast computation speed. In particular, the run time is comparable with the conventional single-image blurring, which causes serious boundary artifacts.

Streamlined approach to high-quality purification and identification of compound series using high-resolution MS and NMR.

PubMed

Mühlebach, Anneke; Adam, Joachim; Schön, Uwe

2011-11-01

Automated medicinal chemistry (parallel chemistry) has become an integral part of the drug-discovery process in almost every large pharmaceutical company. Parallel array synthesis of individual organic compounds has been used extensively to generate diverse structural libraries to support different phases of the drug-discovery process, such as hit-to-lead, lead finding, or lead optimization. In order to guarantee effective project support, efficiency in the production of compound libraries has been maximized. As a consequence, also throughput in chromatographic purification and analysis has been adapted. As a recent trend, more laboratories are preparing smaller, yet more focused libraries with even increasing demands towards quality, i.e. optimal purity and unambiguous confirmation of identity. This paper presents an automated approach how to combine effective purification and structural conformation of a lead optimization library created by microwave-assisted organic synthesis. The results of complementary analytical techniques such as UHPLC-HRMS and NMR are not only regarded but even merged for fast and easy decision making, providing optimal quality of compound stock. In comparison with the previous procedures, throughput times are at least four times faster, while compound consumption could be decreased more than threefold. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Cells as advanced therapeutics: State-of-the-art, challenges, and opportunities in large scale biomanufacturing of high-quality cells for adoptive immunotherapies.

PubMed

Dwarshuis, Nate J; Parratt, Kirsten; Santiago-Miranda, Adriana; Roy, Krishnendu

2017-05-15

Therapeutic cells hold tremendous promise in treating currently incurable, chronic diseases since they perform multiple, integrated, complex functions in vivo compared to traditional small-molecule drugs or biologics. However, they also pose significant challenges as therapeutic products because (a) their complex mechanisms of actions are difficult to understand and (b) low-cost bioprocesses for large-scale, reproducible manufacturing of cells have yet to be developed. Immunotherapies using T cells and dendritic cells (DCs) have already shown great promise in treating several types of cancers, and human mesenchymal stromal cells (hMSCs) are now extensively being evaluated in clinical trials as immune-modulatory cells. Despite these exciting developments, the full potential of cell-based therapeutics cannot be realized unless new engineering technologies enable cost-effective, consistent manufacturing of high-quality therapeutic cells at large-scale. Here we review cell-based immunotherapy concepts focused on the state-of-the-art in manufacturing processes including cell sourcing, isolation, expansion, modification, quality control (QC), and culture media requirements. We also offer insights into how current technologies could be significantly improved and augmented by new technologies, and how disciplines must converge to meet the long-term needs for large-scale production of cell-based immunotherapies. Copyright © 2017 Elsevier B.V. All rights reserved.

The influence of extensive vegetated roofs on runoff water quality.

PubMed

Berndtsson, Justyna Czemiel; Emilsson, Tobias; Bengtsson, Lars

2006-02-15

The influence of extensive sedum-moss vegetated roofs on runoff water quality was studied for four full scale installations located in southern Sweden. The aim of the study was to ascertain whether the vegetated roof behaves as a sink or a source of pollutants and whether the age of a vegetated roof influences runoff quality. The runoff quality from vegetated roofs was also compared with the runoff quality from non-vegetated roofs located in study areas. The following metals and nutrients were investigated: Cd, Cr, Cu, Fe, K, Mn, Pb, Zn, NO3-N, NH4-N, Tot-N, PO4-P, and Tot-P. The results show that, with the exception of nitrogen, vegetated roofs behave as source of contaminants. While in lower concentrations than normally found in urban runoff, some metals appear in concentrations that would correspond to moderately polluted natural water. Nitrate nitrogen is retained by the vegetation or soil or both. Apart from the oldest, the studied vegetated roofs contribute phosphate phosphorus to the runoff. The maintenance of the vegetation systems on the roofs has to be carefully designed in order to avoid storm-water contamination; for instance, the use of easily dissolvable fertilizers should be avoided.

Lot quality assurance sampling for monitoring coverage and quality of a targeted condom social marketing programme in traditional and non-traditional outlets in India

PubMed Central

Piot, Bram; Navin, Deepa; Krishnan, Nattu; Bhardwaj, Ashish; Sharma, Vivek; Marjara, Pritpal

2010-01-01

Objectives This study reports on the results of a large-scale targeted condom social marketing campaign in and around areas where female sex workers are present. The paper also describes the method that was used for the routine monitoring of condom availability in these sites. Methods The lot quality assurance sampling (LQAS) method was used for the assessment of the geographical coverage and quality of coverage of condoms in target areas in four states and along selected national highways in India, as part of Avahan, the India AIDS initiative. Results A significant general increase in condom availability was observed in the intervention area between 2005 and 2008. High coverage rates were gradually achieved through an extensive network of pharmacies and particularly of non-traditional outlets, whereas traditional outlets were instrumental in providing large volumes of condoms. Conclusion LQAS is seen as a valuable tool for the routine monitoring of the geographical coverage and of the quality of delivery systems of condoms and of health products and services in general. With a relatively small sample size, easy data collection procedures and simple analytical methods, it was possible to inform decision-makers regularly on progress towards coverage targets. PMID:20167732

Square2 - A Web Application for Data Monitoring in Epidemiological and Clinical Studies

PubMed

Schmidt, Carsten Oliver; Krabbe, Christine; Schössow, Janka; Albers, Martin; Radke, Dörte; Henke, Jörg

2017-01-01

Valid scientific inferences from epidemiological and clinical studies require high data quality. Data generating departments therefore aim to detect data irregularities as early as possible in order to guide quality management processes. In addition, after the completion of data collections the obtained data quality must be evaluated. This can be challenging in complex studies due to a wide scope of examinations, numerous study variables, multiple examiners, devices, and examination centers. This paper describes a Java EE web application used to monitor and evaluate data quality in institutions with complex and multiple studies, named Square 2 . It uses the Java libraries Apache MyFaces 2, extended by BootsFaces for layout and style. RServe and REngine manage calls to R server processes. All study data and metadata are stored in PostgreSQL. R is the statistics backend and LaTeX is used for the generation of print ready PDF reports. A GUI manages the entire workflow. Square 2 covers all steps in the data monitoring workflow, including the setup of studies and their structure, the handling of metadata for data monitoring purposes, selection of variables, upload of data, statistical analyses, and the generation as well as inspection of quality reports. To take into account data protection issues, Square 2 comprises an extensive user rights and roles concept.

Algorithm for automatic forced spirometry quality assessment: technological developments.

PubMed

Melia, Umberto; Burgos, Felip; Vallverdú, Montserrat; Velickovski, Filip; Lluch-Ariet, Magí; Roca, Josep; Caminal, Pere

2014-01-01

We hypothesized that the implementation of automatic real-time assessment of quality of forced spirometry (FS) may significantly enhance the potential for extensive deployment of a FS program in the community. Recent studies have demonstrated that the application of quality criteria defined by the ATS/ERS (American Thoracic Society/European Respiratory Society) in commercially available equipment with automatic quality assessment can be markedly improved. To this end, an algorithm for assessing quality of FS automatically was reported. The current research describes the mathematical developments of the algorithm. An innovative analysis of the shape of the spirometric curve, adding 23 new metrics to the traditional 4 recommended by ATS/ERS, was done. The algorithm was created through a two-step iterative process including: (1) an initial version using the standard FS curves recommended by the ATS; and, (2) a refined version using curves from patients. In each of these steps the results were assessed against one expert's opinion. Finally, an independent set of FS curves from 291 patients was used for validation purposes. The novel mathematical approach to characterize the FS curves led to appropriate FS classification with high specificity (95%) and sensitivity (96%). The results constitute the basis for a successful transfer of FS testing to non-specialized professionals in the community.

Lot quality assurance sampling for monitoring coverage and quality of a targeted condom social marketing programme in traditional and non-traditional outlets in India.

PubMed

Piot, Bram; Mukherjee, Amajit; Navin, Deepa; Krishnan, Nattu; Bhardwaj, Ashish; Sharma, Vivek; Marjara, Pritpal

2010-02-01

This study reports on the results of a large-scale targeted condom social marketing campaign in and around areas where female sex workers are present. The paper also describes the method that was used for the routine monitoring of condom availability in these sites. The lot quality assurance sampling (LQAS) method was used for the assessment of the geographical coverage and quality of coverage of condoms in target areas in four states and along selected national highways in India, as part of Avahan, the India AIDS initiative. A significant general increase in condom availability was observed in the intervention area between 2005 and 2008. High coverage rates were gradually achieved through an extensive network of pharmacies and particularly of non-traditional outlets, whereas traditional outlets were instrumental in providing large volumes of condoms. LQAS is seen as a valuable tool for the routine monitoring of the geographical coverage and of the quality of delivery systems of condoms and of health products and services in general. With a relatively small sample size, easy data collection procedures and simple analytical methods, it was possible to inform decision-makers regularly on progress towards coverage targets.

Exploiting spatio-temporal characteristics of human vision for mobile video applications

NASA Astrophysics Data System (ADS)

Jillani, Rashad; Kalva, Hari

2008-08-01

Video applications on handheld devices such as smart phones pose a significant challenge to achieve high quality user experience. Recent advances in processor and wireless networking technology are producing a new class of multimedia applications (e.g. video streaming) for mobile handheld devices. These devices are light weight and have modest sizes, and therefore very limited resources - lower processing power, smaller display resolution, lesser memory, and limited battery life as compared to desktop and laptop systems. Multimedia applications on the other hand have extensive processing requirements which make the mobile devices extremely resource hungry. In addition, the device specific properties (e.g. display screen) significantly influence the human perception of multimedia quality. In this paper we propose a saliency based framework that exploits the structure in content creation as well as the human vision system to find the salient points in the incoming bitstream and adapt it according to the target device, thus improving the quality of new adapted area around salient points. Our experimental results indicate that the adaptation process that is cognizant of video content and user preferences can produce better perceptual quality video for mobile devices. Furthermore, we demonstrated how such a framework can affect user experience on a handheld device.

The Impact of Sleep Duration on Performance Among Competitive Athletes: A Systematic Literature Review.

PubMed

Kirschen, Gregory W; Jones, Jason J; Hale, Lauren

2018-06-14

The athletic advantage of sleep, although commonly touted by coaches, trainers, and sports physicians, is still unclear and likely varies by sport, athletic performance metric, and length of sufficient or insufficient sleep. Although recent literature reviews have highlighted circadian and nutritional factors that influence different aspects of athletic performance, a systematic summary of the effects of sleep duration and sleep quality on performance among competitive athletes is lacking. Here we systematically review the relationship between sleep duration and sleep quality and objective athletic performance among competitive athletes across 19 studies representing 12 sports. Taken holistically, we find that the sports requiring speed, tactical strategy, and technical skill are most sensitive to sleep duration manipulations. Furthermore, longer-term sleep manipulations are more likely than acute sleep manipulations (whether deprivation or extension) to affect athletic performance. Thus, the importance of sleep for competitive athletes to achieve high performance is dependent on the demands of the sport as well as the length of sleep interventions. In light of the limited number of studies investigating sleep quality and performance, the potential relevance of subjective sleep quality remains an interesting question for future work.

Use of multiple sensor technologies for quality control of in situ biogeochemical measurements: A SeaCycler case study

NASA Astrophysics Data System (ADS)

Atamanchuk, Dariia; Koelling, Jannes; Lai, Jeremy; Send, Uwe; Wallace, Douglas

2017-04-01

Over the last two decades observing capacity for the global ocean has increased dramatically. Emerging sensor technologies for dissolved gases, nutrients and bio-optical properties in seawater are allowing extension of in situ observations beyond the traditionally measured salinity, temperature and pressure (CTD). However the effort to extend observations using autonomous instruments and platforms carries the risk of losing the level of data quality achievable through conventional water sampling techniques. We will present results from a case study with the SeaCycler profiling winch focusing on quality control of the in-situ measurements. A total of 13 sensors were deployed from May 2016 to early 2017 on SeaCycler's profiling sensor float, including CTD, dissolved oxygen (O2, 3 sensors), carbon dioxide (pCO2, 2 sensors), nutrients, velocity sensors, fluorometer, transmissometer, single channel PAR sensor, and others. We will highlight how multiple measurement technologies (e.g. for O2 and CO2) complement each other and result in a high quality data product. We will also present an initial assessment of the bio-optical data, their implications for seasonal phytoplankton dynamics and comparisons to climatologies and ocean-color data products obtained from the MODIS satellite.

Proximity correction of high-dosed frame with PROXECCO

NASA Astrophysics Data System (ADS)

Eisenmann, Hans; Waas, Thomas; Hartmann, Hans

1994-05-01

Usefulness of electron beam lithography is strongly related to the efficiency and quality of methods used for proximity correction. This paper addresses the above issue by proposing an extension to the new proximity correction program PROXECCO. The combination of a framing step with PROXECCO produces a pattern with a very high edge accuracy and still allows usage of the fast correction procedure. Making a frame with a higher dose imitates a fine resolution correction where the coarse part is disregarded. So after handling the high resolution effect by means of framing, an additional coarse correction is still needed. Higher doses have a higher contribution to the proximity effect. This additional proximity effect is taken into account with the help of the multi-dose input of PROXECCO. The dose of the frame is variable, depending on the deposited energy coming from backscattering of the proximity. Simulation proves the very high edge accuracy of the applied method.

Risk-adapted monitoring is not inferior to extensive on-site monitoring: Results of the ADAMON cluster-randomised study.

PubMed

Brosteanu, Oana; Schwarz, Gabriele; Houben, Peggy; Paulus, Ursula; Strenge-Hesse, Anke; Zettelmeyer, Ulrike; Schneider, Anja; Hasenclever, Dirk

2017-12-01

Background According to Good Clinical Practice, clinical trials must protect rights and safety of patients and make sure that the trial results are valid and interpretable. Monitoring on-site has an important role in achieving these objectives; it controls trial conduct at trial sites and informs the sponsor on systematic problems. In the past, extensive on-site monitoring with a particular focus on formal source data verification often lost sight of systematic problems in study procedures that endanger Good Clinical Practice objectives. ADAMON is a prospective, stratified, cluster-randomised, controlled study comparing extensive on-site monitoring with risk-adapted monitoring according to a previously published approach. Methods In all, 213 sites from 11 academic trials were cluster-randomised between extensive on-site monitoring (104) and risk-adapted monitoring (109). Independent post-trial audits using structured manuals were performed to determine the frequency of major Good Clinical Practice findings at the patient level. The primary outcome measure is the proportion of audited patients with at least one major audit finding. Analysis relies on logistic regression incorporating trial and monitoring arm as fixed effects and site as random effect. The hypothesis was that risk-adapted monitoring is non-inferior to extensive on-site monitoring with a non-inferiority margin of 0.60 (logit scale). Results Average number of monitoring visits and time spent on-site was 2.1 and 2.7 times higher in extensive on-site monitoring than in risk-adapted monitoring, respectively. A total of 156 (extensive on-site monitoring: 76; risk-adapted monitoring: 80) sites were audited. In 996 of 1618 audited patients, a total of 2456 major audit findings were documented. Depending on the trial, findings were identified in 18%-99% of the audited patients, with no marked monitoring effect in any of the trials. The estimated monitoring effect is -0.04 on the logit scale with two-sided 95% confidence interval (-0.40; 0.33), demonstrating that risk-adapted monitoring is non-inferior to extensive on-site monitoring. At most, extensive on-site monitoring could reduce the frequency of major Good Clinical Practice findings by 8.2% compared with risk-adapted monitoring. Conclusion Compared with risk-adapted monitoring, the potential benefit of extensive on-site monitoring is small relative to overall finding rates, although risk-adapted monitoring requires less than 50% of extensive on-site monitoring resources. Clusters of findings within trials suggest that complicated, overly specific or not properly justified protocol requirements contributed to the overall frequency of findings. Risk-adapted monitoring in only a sample of patients appears sufficient to identify systematic problems in the conduct of clinical trials. Risk-adapted monitoring has a part to play in quality control. However, no monitoring strategy can remedy defects in quality of design. Monitoring should be embedded in a comprehensive quality management approach covering the entire trial lifecycle.

Risk-adapted monitoring is not inferior to extensive on-site monitoring: Results of the ADAMON cluster-randomised study

PubMed Central

Brosteanu, Oana; Schwarz, Gabriele; Houben, Peggy; Paulus, Ursula; Strenge-Hesse, Anke; Zettelmeyer, Ulrike; Schneider, Anja; Hasenclever, Dirk

2017-01-01

Background According to Good Clinical Practice, clinical trials must protect rights and safety of patients and make sure that the trial results are valid and interpretable. Monitoring on-site has an important role in achieving these objectives; it controls trial conduct at trial sites and informs the sponsor on systematic problems. In the past, extensive on-site monitoring with a particular focus on formal source data verification often lost sight of systematic problems in study procedures that endanger Good Clinical Practice objectives. ADAMON is a prospective, stratified, cluster-randomised, controlled study comparing extensive on-site monitoring with risk-adapted monitoring according to a previously published approach. Methods In all, 213 sites from 11 academic trials were cluster-randomised between extensive on-site monitoring (104) and risk-adapted monitoring (109). Independent post-trial audits using structured manuals were performed to determine the frequency of major Good Clinical Practice findings at the patient level. The primary outcome measure is the proportion of audited patients with at least one major audit finding. Analysis relies on logistic regression incorporating trial and monitoring arm as fixed effects and site as random effect. The hypothesis was that risk-adapted monitoring is non-inferior to extensive on-site monitoring with a non-inferiority margin of 0.60 (logit scale). Results Average number of monitoring visits and time spent on-site was 2.1 and 2.7 times higher in extensive on-site monitoring than in risk-adapted monitoring, respectively. A total of 156 (extensive on-site monitoring: 76; risk-adapted monitoring: 80) sites were audited. In 996 of 1618 audited patients, a total of 2456 major audit findings were documented. Depending on the trial, findings were identified in 18%–99% of the audited patients, with no marked monitoring effect in any of the trials. The estimated monitoring effect is −0.04 on the logit scale with two-sided 95% confidence interval (−0.40; 0.33), demonstrating that risk-adapted monitoring is non-inferior to extensive on-site monitoring. At most, extensive on-site monitoring could reduce the frequency of major Good Clinical Practice findings by 8.2% compared with risk-adapted monitoring. Conclusion Compared with risk-adapted monitoring, the potential benefit of extensive on-site monitoring is small relative to overall finding rates, although risk-adapted monitoring requires less than 50% of extensive on-site monitoring resources. Clusters of findings within trials suggest that complicated, overly specific or not properly justified protocol requirements contributed to the overall frequency of findings. Risk-adapted monitoring in only a sample of patients appears sufficient to identify systematic problems in the conduct of clinical trials. Risk-adapted monitoring has a part to play in quality control. However, no monitoring strategy can remedy defects in quality of design. Monitoring should be embedded in a comprehensive quality management approach covering the entire trial lifecycle. PMID:28786330

Racial Differences in Veterans’ Satisfaction With Examination of Disability From Posttraumatic Stress Disorder

PubMed Central

Rosen, Marc I.; Afshartous, David; Nwosu, Sam; Scott, Melanie C.; Jackson, James C.; Marx, Brian; Murdoch, Maureen; Sinnot, Patrica L.; Speroff, Theodore

2013-01-01

Objective The examination to determine if a veteran has service-connected posttraumatic stress disorder (PTSD) affects veterans’ lives for years afterwards. This study examined factors potentially associated with veterans’ perception of their examination’s quality. Methods Three hundred eighty-four veterans participated in a clinical trial in which they received either a semi-structured interview or the examiner’s usual interview. Immediately after the interview, veterans completed confidential ratings of the examination’s quality and of their examiners’ interpersonal qualities and competence. Extensive data characterizing the veterans, the 33 participating examiners, and the examinations themselves were collected. Results Forty-seven percent of Caucasian veterans versus 34% of African American veterans rated their examination quality as “excellent.” In multivariate analysis, African Americans were less likely than Caucasians to assign a higher quality rating (odds ratio .61, 95% confidence interval .38 – .99). African Americans also rated their examiners as having significantly worse interpersonal qualities but not lower competence. Ratings were not significantly related to the veterans' age, gender, marital status, eventual diagnosis with PTSD, Global Assessment of Functioning score, the examiners’ perception of the prevalence of malingering, or the presence of a third party in the examination. Conclusions Ratings of disability examinations were generally high, although African American veterans' ratings were less favorable than Caucasian veterans' ratings. PMID:23318842

Optical Fiber Design And Fabrication: Discussion On Recent Developments

NASA Astrophysics Data System (ADS)

Roy, Philippe; Devautour, Mathieu; Lavoute, Laure; Gaponov, Dmitry; Brasse, Gurvan; Hautreux, Stéphanie; Février, Sébastien; Restoin, Christine; Auguste, Jean-Louis; Gérôme, Frédéric; Humbert, Georges; Blondy, Jean-Marc

2008-10-01

Level of emitted power and beam quality of singlemode fiber lasers have been drastically increased at the expense of loss due to bend sensitivity, simplicity of manufacturing and packaging. Furthermore, the extension of the spectral coverage was primarily explored by exploiting non-linear effects, neglecting numerous possible transitions of rare earths. Through different research areas, we demonstrate the possibilities offered by new fiber designs and alternative methods of manufacturing. Photonic Band Gap fibers reconcile diffraction limited beam and large mode area with low bending loss. 80% slope efficiency is demonstrated together with a robust propagation allowing the fiber to be tightly bent until wounding radii as small as 6 cm. Highly ytterbium doped multimode core surrounded by high refractive index rods fiber exhibits a transverse singlemode behavior under continuous wave laser regime. A robust LP01 mode is observed and filtering effect is clearly observed. A non CVD process based on silica sand vitrification allows the synthesis of large and highly doped core with high index homogeneity, opening the way to design of efficient large mode area fiber lasers. 74% slope efficiency is measured, demonstrating the good quality of the core material. Finally, the use of rare earth (Er3+) doped zirconia nanocrystals in silica matrix offers a large panel of ignored energy transitions for visible or off-usual band of emission.

The impacts of gingivitis and calculus on Thai children's quality of life.

PubMed

Krisdapong, Sudaduang; Prasertsom, Piyada; Rattanarangsima, Khanit; Sheiham, Aubrey; Tsakos, Georgios

2012-09-01

To assess associations of socio-demographic, behavioural and the extent of gingivitis and calculus with oral health-related quality of life (OHRQoL) in nationally representative samples of 12- and 15-year-old Thai children. In the Thailand National Oral Health Survey, 1,063 twelve-year olds and 811 fifteen-year olds were clinically examined and interviewed for OHRQoL using the Child-OIDP and OIDP indices, respectively, and completed a behavioural questionnaire. We assessed associations of condition-specific impacts (CS-impacts) with gingivitis and calculus, adjusted for socio-demographic and behavioural factors. Gingivitis and calculus were highly prevalent: 79.3% in 12-year and 81.5% in 15-year olds. CS-impacts relating to calculus and/or gingivitis were reported by 26.0% of 12-year and 29.6% of 15-year olds. Except for calculus without gingivitis, calculus and/or gingivitis in any form was significantly related to any level of CS-impacts. At a moderate or higher level of CS-impacts, there were significant relationships with extensive calculus and/or gingivitis in 12-year olds and for extensive gingivitis and gingivitis without calculus in 15-year olds. Gingivitis was generally associated with any level of CS-impacts attributed to calculus and/or gingivitis. CS-impacts were related more to gingivitis than to calculus. © 2012 John Wiley & Sons A/S.

Effects of red, far-red and blue light in maintaining growth in latitudinal populations of Norway spruce (Picea abies).

PubMed

Mølmann, Jørgen Alexander; Junttila, Olavi; Johnsen, Oystein; Olsen, Jorunn Elisabeth

2006-02-01

Seedlings of trees with a free growth pattern cease growth when night-lengths become shorter than a critical value, and this critical night-length (CNL) decreases with increasing latitude of origin. In northern populations, the light quality also appears to play an important role and a clinal variation in requirement for far-red (FR) light has been documented. In this study we dissected the light quality requirements for maintaining growth in different latitudinal populations of Norway spruce (Picea abies (L.) H. Karst.) using light emitting diodes for red (R), FR and blue (B) light, as 12 h day extension to provide 24 h photoperiod. At equal spectral photon flux, FR light was more effective than R light in maintaining growth, and the requirement of both R and FR increased with northern latitude of origin. One-to-one mixtures of R and FR light were more effective in maintaining growth than either FR or R light alone, indicating a possible interaction between R and FR light maintaining growth. Using the blue light as day extension could not prevent growth cessation in any of the populations, but delayed the bud set slightly in all populations. Our results suggest that phytochrome(s) are the primary photoreceptors in high irradiance responses maintaining growth in Norway spruce seedlings.

Shelf life extension of whole Norway lobster Nephrops norvegicus using modified atmosphere packaging.

PubMed

Gornik, Sebastian G; Albalat, Amaya; Theethakaew, Chonchanok; Neil, Douglas M

2013-11-01

Once a nuisance by-catch, today the Norway lobster (Nephrops norvegicus) is a valuable UK fisheries commodity. Unfortunately, the species is very susceptible to quality deterioration post harvest as it quickly develops black spots and also spoils rapidly due to bacterial growth. Treatment with chemicals can stop the blackening and carefully monitored cold storage can result in a sensory shelf life of up to 6.5 days. The high susceptibility to spoilage greatly restricts the extent to which N. norvegicus can be distributed to retailers and displayed for sale. The application of modified atmosphere (MA) could be extremely beneficial, allowing the chilled product to stay fresh for a long period of time, thus ensuring higher sales. In the present study, we identified a gas mix for the MA packaging (MAP) of whole N. norvegicus lobster into 200 g retail packs. Our results show that a shelf life extension to 13 days can be achieved when retail packs are stored in MAP at 1 °C. Effectiveness of the MAP was evaluated by using a newly developed QIM for MA-packaged whole N. norvegicus and also by analyzing bacterial plate counts. Changes in the microflora and effects of different storage temperatures on the quality of the MA packs are also presented. The main specific spoilage organism (SSO) of modified atmosphere packaged Norway lobster is Photobacterium phosphoreum. © 2013.

Uses of Lotem for Indonesian hydrocarbon applications

NASA Astrophysics Data System (ADS)

Aftartu, R.; Strack, K.

2017-07-01

While magnetotellurics has been used extensively in Indonesia, the percentage of good quality data is limited due to the high population density and often the geologic condition. We investigate application of controlled source electromagnetics (CSEM) in the time domain, sometimes also known as long-offset transient electromagnetics (Lotem) because it overcomes the noise issue by using a high-power transmitter. Among many applications for Indonesia we have selected sub-basalt where we can demonstrate the benefit of the technology with successful Lotem case histories of the past and illustrate its new use with 3D modeling. Either diffuse reflection of the seismic wave or high seismic velocities hinder it. EM sees transparently through them. Targets are resistive (hydrocarbon) and conductive (sediments). We are illustrating the success of Lotem with results from Europe and India for similar situations including joint inversion with magnetotellurics.

The development of a tunable, single-frequency ultraviolet laser source for UV filtered Rayleigh scattering

NASA Technical Reports Server (NTRS)

Finkelstein, N.; Gambogi, J.; Lempert, Walter R.; Miles, Richard B.; Rines, G. A.; Finch, A.; Schwarz, R. A.

1995-01-01

We present the development of a flexible, high power, narrow line width, tunable ultraviolet source for diagnostic application. By frequency tripling the output of a pulsed titanium-sapphire laser, we achieve broadly tunable (227-360 nm) ultraviolet light with high quality spatial and spectral resolution. We also present the characterization of a mercury vapor cell which provides a narrow band, sharp edge absorption filter at 253.7 nm. These two components form the basis for the extension of the Filtered Rayleigh Scattering technique into the ultraviolet. The UV-FRS system is comprised of four pieces: a single frequency, cw tunable Ti:Sapphire seeding source; a high-powered pulsed Ti:Sapphire oscillator; a third harmonic generator system; and an atomic mercury vapor filter. In this paper we discuss the development and characterization of each of these elements.

Experimental realization of underdense plasma photocathode wakefield acceleration at FACET

NASA Astrophysics Data System (ADS)

Scherkl, Paul

2017-10-01

Novel electron beam sources from compact plasma accelerator concepts currently mature into the driving technology for next generation high-energy physics and light source facilities. Particularly electron beams of ultra-high brightness could pave the way for major advances for both scientific and commercial applications, but their generation remains tremendously challenging. The presentation outlines the experimental demonstration of the world's first bright electron beam source from spatiotemporally synchronized laser pulses injecting electrons into particle-driven plasma wakefields at FACET. Two distinctive types of operation - laser-triggered density downramp injection (``Plasma Torch'') and underdense plasma photocathode acceleration (``Trojan Horse'') - and their intermediate transitions are characterized and contrasted. Extensive particle-in-cell simulations substantiate the presentation of experimental results. In combination with novel techniques to minimize the beam energy spread, the acceleration scheme presented here promises ultra-high beam quality and brightness.

75 FR 2935 - Extension of Deadline for Promulgating Designations for the 2008 Ozone National Ambient Air...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-19

... Part II Environmental Protection Agency 40 CFR Parts 50, 58 and 81 Ozone National Ambient Air... 2008 Ozone National Ambient Air Quality Standards AGENCY: Environmental Protection Agency (EPA). ACTION... designations for the ozone national ambient air quality standards (NAAQS) that were promulgated in March 2008...

Author Affiliation Index: A New Approach to Marketing Journal Ranking

ERIC Educational Resources Information Center

Pan, Yue; Chen, Carl R.

2011-01-01

Previous research has adopted various methods to assess the relative quality of academic marketing journals. This study, as a replication and extension of Chen and Huang (2007), introduces the Author Affiliation Index (AAI) as an alternative approach to assessing marketing journal quality. The AAI is defined as the ratio of articles authored by…

75 FR 32160 - Certain Hot-Rolled Flat-Rolled Carbon-Quality Steel Products from Brazil: Extension of Time Limit...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-07

... DEPARTMENT OF COMMERCE International Trade Administration [C-351-829] Certain Hot-Rolled Flat... Commerce (the Department) published the countervailing duty order on certain hot-rolled flat- rolled carbon-quality steel products from Brazil. See Agreement Suspending the Countervailing Duty Investigation on Hot...

Interactions between 1-MCP and controlled atmosphere storage on quality and storage disorders of fruits and vegetable.

USDA-ARS?s Scientific Manuscript database

The use of 1-methycyclopropene (1-MCP) to maintain quality attributes of horticultural products has been investigated extensively. Commercial applications of 1-MCP (SmartFreshTM), are made to a range of horticultural crops, including avocados, bananas, melons, persimmons and tomatoes, but the major...

Interactions between 1-MCP and controlled atmospheres on quality and storage disorders of fruits and vegetable

USDA-ARS?s Scientific Manuscript database

The use of 1-methycyclopropene (1-MCP) to maintain quality attributes of horticultural products has been investigated extensively. Commercial applications of 1-MCP (SmartFreshTM), are made to a range of horticultural crops, including avocados, bananas, melons, persimmons and tomatoes, but the major...

Grain dormancy and light quality effects on germination in the model grass Brachypodium distachyon

USDA-ARS?s Scientific Manuscript database

Lack of seed dormancy in cereal crops such as barley and wheat is a common problem affecting farming areas around the world, causing losses in yield and quality due to pre-harvest sprouting. Control of seed dormancy has been investigated extensively using various approaches in different species incl...

Comparing Measures of Voice Quality from Sustained Phonation and Continuous Speech

ERIC Educational Resources Information Center

Gerratt, Bruce R.; Kreiman, Jody; Garellek, Marc

2016-01-01

Purpose: The question of what type of utterance--a sustained vowel or continuous speech--is best for voice quality analysis has been extensively studied but with equivocal results. This study examines whether previously reported differences derive from the articulatory and prosodic factors occurring in continuous speech versus sustained phonation.…

77 FR 22550 - Approval and Promulgation of Air Quality Implementation Plans; New Hampshire; Regional Haze...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-16

... and Promulgation of Air Quality Implementation Plans; New Hampshire; Regional Haze; Reopening of... regional haze for the first planning period from 2008 through 2018. Two commentors requested an extension... supplemental submittals on January 14, 2011, and August 26, 2011, that addresses regional haze for the first...

A World of Brands: Higher Education and the Emergence of Multinational Quality Franchises

ERIC Educational Resources Information Center

Blanco Ramírez, Gerardo

2014-01-01

This article explores the concepts of "brand" and "franchise" in the development of international quality assurance. The impact of corporate language and culture on higher education is evident and has been extensively analysed. Recent attention given to branding of universities reflects the ever-growing influence of corporate…

Academic Developers as Change Agents Improving Quality in a Large Interprofessional Undergraduate Subject

ERIC Educational Resources Information Center

Cordiner, Moira

2014-01-01

Much has been written about academic developers as change agents but not in an interprofessional education (IPE) context. IPE involves teaching students in different health professions how to work effectively in teams across professional boundaries to improve the quality of patient care. Extensive evidence reveals that implementing sustainable IPE…

76 FR 25710 - Comment Request for Information Collection for Employment and Training (ET) Handbook 336, 18th...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-05

...) Handbook 336, 18th Edition: ``Unemployment Insurance (UI) State Quality Service Plan Planning (SQSP) and... proposed extension to ET Handbook 336, 18th Edition: ``Unemployment Insurance (UI) State Quality Service.... ADDRESSES: Submit written comments to the Employment and Training Administration, Office of Unemployment...

The enigma of aluminum deposition in bone tissue from a patient with chronic kidney disease: a case report.

PubMed

Meira, Rodrigo Dias de; Carbonara, Cinthia Esbrile Moraes; Quadros, Kélcia Rosana da Silva; Santos, Carolina Urbini Dos; Schincariol, Patrícia; Pêssoa, Gustavo de Souza; Arruda, Marco Aurélio Zezzi; Jorgetti, Vanda; Oliveira, Rodrigo Bueno de

2018-06-04

About four decades ago, the relationship between dialysis-dementia and aluminum (Al) began to be established. The restriction of drugs containing Al and improvements on water quality used for dialysis resulted in the clinical disappearance of Al intoxication. However, high prevalence of Al deposition in bone tissue from Brazilian dialysis patients is still being detected. Through the case report of a patient on hemodialysis (HD) for one year, presenting significant Al deposition in bone tissue, we speculated if this problem is not being underestimated. We used extensive investigation to identify potential sources of Al exposure with a careful review of medication history and water quality controls. Al concentration was measured by different methods, including mass spectrometry, in poly-electrolyte concentrate solutions and solution for peritoneal dialysis, in an attempt to elucidate the possible sources of contamination. The objective of this case report is to alert the medical community about a potential high prevalence of Al deposition in bone tissue and to discuss the possible sources of contamination in patients with chronic kidney disease (CKD).

HAMAP in 2013, new developments in the protein family classification and annotation system

PubMed Central

Pedruzzi, Ivo; Rivoire, Catherine; Auchincloss, Andrea H.; Coudert, Elisabeth; Keller, Guillaume; de Castro, Edouard; Baratin, Delphine; Cuche, Béatrice A.; Bougueleret, Lydie; Poux, Sylvain; Redaschi, Nicole; Xenarios, Ioannis; Bridge, Alan

2013-01-01

HAMAP (High-quality Automated and Manual Annotation of Proteins—available at http://hamap.expasy.org/) is a system for the classification and annotation of protein sequences. It consists of a collection of manually curated family profiles for protein classification, and associated annotation rules that specify annotations that apply to family members. HAMAP was originally developed to support the manual curation of UniProtKB/Swiss-Prot records describing microbial proteins. Here we describe new developments in HAMAP, including the extension of HAMAP to eukaryotic proteins, the use of HAMAP in the automated annotation of UniProtKB/TrEMBL, providing high-quality annotation for millions of protein sequences, and the future integration of HAMAP into a unified system for UniProtKB annotation, UniRule. HAMAP is continuously updated by expert curators with new family profiles and annotation rules as new protein families are characterized. The collection of HAMAP family classification profiles and annotation rules can be browsed and viewed on the HAMAP website, which also provides an interface to scan user sequences against HAMAP profiles. PMID:23193261

Coexpression of the High Molecular Weight Glutenin Subunit 1Ax1 and Puroindoline Improves Dough Mixing Properties in Durum Wheat (Triticum turgidum L. ssp. durum)

PubMed Central

Li, Xiaoyan; Xiao, Xin; Sun, Fusheng; Wang, Cheng; Hu, Wei; Feng, Zhijuan; Chang, Junli; Chen, Mingjie; Wang, Yuesheng; Li, Kexiu; Yang, Guangxiao; He, Guangyuan

2012-01-01

Wheat end-use quality mainly derives from two interrelated characteristics: the compositions of gluten proteins and grain hardness. The composition of gluten proteins determines dough rheological properties and thus confers the unique viscoelastic property on dough. One group of gluten proteins, high molecular weight glutenin subunits (HMW-GS), plays an important role in dough functional properties. On the other hand, grain hardness, which influences the milling process of flour, is controlled by Puroindoline a (Pina) and Puroindoline b (Pinb) genes. However, little is known about the combined effects of HMW-GS and PINs on dough functional properties. In this study, we crossed a Pina-expressing transgenic line with a 1Ax1-expressing line of durum wheat and screened out lines coexpressing 1Ax1 and Pina or lines expressing either 1Ax1 or Pina. Dough mixing analysis of these lines demonstrated that expression of 1Ax1 improved both dough strength and over-mixing tolerance, while expression of PINA detrimentally affected the dough resistance to extension. In lines coexpressing 1Ax1 and Pina, faster hydration of flour during mixing was observed possibly due to the lower water absorption and damaged starch caused by PINA expression. In addition, expression of 1Ax1 appeared to compensate the detrimental effect of PINA on dough resistance to extension. Consequently, coexpression of 1Ax1 and PINA in durum wheat had combined effects on dough mixing behaviors with a better dough strength and resistance to extension than those from lines expressing either 1Ax1 or Pina. The results in our study suggest that simultaneous modulation of dough strength and grain hardness in durum wheat could significantly improve its breadmaking quality and may not even impair its pastamaking potential. Therefore, coexpression of 1Ax1 and PINA in durum wheat has useful implications for breeding durum wheat with dual functionality (for pasta and bread) and may improve the economic values of durum wheat. PMID:23185532

Coexpression of the high molecular weight glutenin subunit 1Ax1 and puroindoline improves dough mixing properties in durum wheat (Triticum turgidum L. ssp. durum).

PubMed

Li, Yin; Wang, Qiong; Li, Xiaoyan; Xiao, Xin; Sun, Fusheng; Wang, Cheng; Hu, Wei; Feng, Zhijuan; Chang, Junli; Chen, Mingjie; Wang, Yuesheng; Li, Kexiu; Yang, Guangxiao; He, Guangyuan

2012-01-01

Wheat end-use quality mainly derives from two interrelated characteristics: the compositions of gluten proteins and grain hardness. The composition of gluten proteins determines dough rheological properties and thus confers the unique viscoelastic property on dough. One group of gluten proteins, high molecular weight glutenin subunits (HMW-GS), plays an important role in dough functional properties. On the other hand, grain hardness, which influences the milling process of flour, is controlled by Puroindoline a (Pina) and Puroindoline b (Pinb) genes. However, little is known about the combined effects of HMW-GS and PINs on dough functional properties. In this study, we crossed a Pina-expressing transgenic line with a 1Ax1-expressing line of durum wheat and screened out lines coexpressing 1Ax1 and Pina or lines expressing either 1Ax1 or Pina. Dough mixing analysis of these lines demonstrated that expression of 1Ax1 improved both dough strength and over-mixing tolerance, while expression of PINA detrimentally affected the dough resistance to extension. In lines coexpressing 1Ax1 and Pina, faster hydration of flour during mixing was observed possibly due to the lower water absorption and damaged starch caused by PINA expression. In addition, expression of 1Ax1 appeared to compensate the detrimental effect of PINA on dough resistance to extension. Consequently, coexpression of 1Ax1 and PINA in durum wheat had combined effects on dough mixing behaviors with a better dough strength and resistance to extension than those from lines expressing either 1Ax1 or Pina. The results in our study suggest that simultaneous modulation of dough strength and grain hardness in durum wheat could significantly improve its breadmaking quality and may not even impair its pastamaking potential. Therefore, coexpression of 1Ax1 and PINA in durum wheat has useful implications for breeding durum wheat with dual functionality (for pasta and bread) and may improve the economic values of durum wheat.

Wildfire and the future of water supply.

PubMed

Bladon, Kevin D; Emelko, Monica B; Silins, Uldis; Stone, Micheal

2014-08-19

In many parts of the world, forests provide high quality water for domestic, agricultural, industrial, and ecological needs, with water supplies in those regions inextricably linked to forest health. Wildfires have the potential to have devastating effects on aquatic ecosystems and community drinking water supply through impacts on water quantity and quality. In recent decades, a combination of fuel load accumulation, climate change, extensive droughts, and increased human presence in forests have resulted in increases in area burned and wildfire severity-a trend predicted to continue. Thus, the implications of wildfire for many downstream water uses are increasingly concerning, particularly the provision of safe drinking water, which may require additional treatment infrastructure and increased operations and maintenance costs in communities downstream of impacted landscapes. A better understanding of the effects of wildfire on water is needed to develop effective adaptation and mitigation strategies to protect globally critical water supplies originating in forested environments.

Gamma/Hadron Separation for the HAWC Observatory

NASA Astrophysics Data System (ADS)

Gerhardt, Michael J.

The High-Altitude Water Cherenkov (HAWC) Observatory is a gamma-ray observatory sensitive to gamma rays from 100 GeV to 100 TeV with an instantaneous field of view of ˜2 sr. It is located on the Sierra Negra plateau in Mexico at an elevation of 4,100 m and began full operation in March 2015. The purpose of the detector is to study relativistic particles that are produced by interstellar and intergalactic objects such as: pulsars, supernova remnants, molecular clouds, black holes and more. To achieve optimal angular resolution, energy reconstruction and cosmic ray background suppression for the extensive air showers detected by HAWC, good timing and charge calibration are crucial, as well as optimization of quality cuts on background suppression variables. Additions to the HAWC timing calibration, in particular automating the calibration quality checks and a new method for background suppression using a multivariate analysis are presented in this thesis.

Elemental abundance analyses with Complejo Astronomico El Leoncito REOSC echelle spectrograms. IV. Extensions of nine previous analyses

NASA Astrophysics Data System (ADS)

Adelman, S. J.; Pintado, O. I.

2000-02-01

Using new CASLEO echelle spectrograms, we extended our elemental abundances of the sharp-lined Mercury-Manganese stars mu Lep, 14 Hya, kappa Cnc, HR 4487, HR 4817, 28 Her, and HR 7245, the closely related star 3 Cen A, and 7 Sex an A0 V star with Population I abundances, but with Population II star space motions. The lambda lambda 4500-6200 region contains a sufficient number of lines to derive high-quality abundances of these stars. For most stars, the new spectra provide additional lines for the analyses which improve their quality as well as help fill in the periodic table. Table~5 is only available in electronic form at the CDS via anonymous ftp to cdsarc.u-strasbg.fr(130.79.128.5) or via http://cdsweb.u-strabg.fr/Abstract.html}

Semiautomated Device for Batch Extraction of Metabolites from Tissue Samples

PubMed Central

2012-01-01

Metabolomics has become a mainstream analytical strategy for investigating metabolism. The quality of data derived from these studies is proportional to the consistency of the sample preparation. Although considerable research has been devoted to finding optimal extraction protocols, most of the established methods require extensive sample handling. Manual sample preparation can be highly effective in the hands of skilled technicians, but an automated tool for purifying metabolites from complex biological tissues would be of obvious utility to the field. Here, we introduce the semiautomated metabolite batch extraction device (SAMBED), a new tool designed to simplify metabolomics sample preparation. We discuss SAMBED’s design and show that SAMBED-based extractions are of comparable quality to extracts produced through traditional methods (13% mean coefficient of variation from SAMBED versus 16% from manual extractions). Moreover, we show that aqueous SAMBED-based methods can be completed in less than a quarter of the time required for manual extractions. PMID:22292466

Predictors for work participation in individuals with an Autism spectrum disorder: a systematic review.

PubMed

Holwerda, Anja; van der Klink, Jac J L; Groothoff, Johan W; Brouwer, Sandra

2012-09-01

Research shows that only about 25% of people with autism are employed. We conducted a systematic review on factors facilitating or hindering work participation of people with autism in longitudinal studies. An extensive search in biomedical and psychological databases yielded 204 articles and 18 satisfied all inclusion criteria. We assessed the methodological quality of included studies using an established criteria list. Seventeen factors were identified and categorized as disease-related factors, personal factors or external factors. Limited cognitive ability was the only significant predictor consistently found for work outcome. Functional independence and institutionalization were both reported by one study to be significantly related to work outcome. Inconsistent findings or non significant findings were reported for the other fourteen factors. These findings emphasize the need for more high quality cohort studies focussing on work participation as the main outcome among people with Autism.

The use of hydrodynamic vortex separators and screening systems to improve water quality.

PubMed

Andoh, R Y G; Saul, A J

2003-01-01

The paper reviews the evolution of Hydrodynamic Vortex Separators (HDVS) in the context of application as high rate rotary flow separators for achieving water quality improvements to meet with regulatory requirements in Europe and North America. The types of HDVS and their application for the control of wet-weather discharges such as combined sewer overflows (CSOs), sanitary sewer overflows (SSOs) and stormwater are outlined and a number of myths surrounding their use, dispelled. Reference is made to outputs of peer reviewed comprehensive monitoring, evaluation and demonstration projects on pilot and full-scale installations to demonstrate the efficacy and extensive track record of these systems. Recent developments and innovations in HDVS technologies are discussed, focusing on their combined use as solids liquid separators, contact vessels for wastewater disinfection, the incorporation of self-cleansing screening devices for the control of aesthetic pollutants (e.g. floatables) and the use of computational modelling for optimisation.

Advances in diffusion MRI acquisition and processing in the Human Connectome Project

PubMed Central

Sotiropoulos, Stamatios N; Jbabdi, Saad; Xu, Junqian; Andersson, Jesper L; Moeller, Steen; Auerbach, Edward J; Glasser, Matthew F; Hernandez, Moises; Sapiro, Guillermo; Jenkinson, Mark; Feinberg, David A; Yacoub, Essa; Lenglet, Christophe; Ven Essen, David C; Ugurbil, Kamil; Behrens, Timothy EJ

2013-01-01

The Human Connectome Project (HCP) is a collaborative 5-year effort to map human brain connections and their variability in healthy adults. A consortium of HCP investigators will study a population of 1200 healthy adults using multiple imaging modalities, along with extensive behavioral and genetic data. In this overview, we focus on diffusion MRI (dMRI) and the structural connectivity aspect of the project. We present recent advances in acquisition and processing that allow us to obtain very high-quality in-vivo MRI data, while enabling scanning of a very large number of subjects. These advances result from 2 years of intensive efforts in optimising many aspects of data acquisition and processing during the piloting phase of the project. The data quality and methods described here are representative of the datasets and processing pipelines that will be made freely available to the community at quarterly intervals, beginning in 2013. PMID:23702418

Photogrammetric registration of dental plaque accumulation in vivo.

PubMed

Bergström, J

1981-01-01

Using the labial surface of upper anterior laterals for determination, the accumulation of plaque was assessed by means of a stereo-photogrammetric method. The stereoimages were subjected to photogrammetric evaluation, the part of the surface area covered by plaque being given in per cent of the total surface area of the tooth. Plaque extension and plaque topography was studied in young adults with healthy periodontia during a 20 day period of no oral hygiene. At the end of the experimental period, on an average 75 per cent of the surface area was covered by plaque, corresponding to an extension rate of 3.75 per cent per day. The correlation between plaque values obtained by photogrammetry and various estimates obtained from clinical scoring ranged between r = 0.66 and r = 0.78. It is concluded that the method introduced is a sensitive means of determining small amounts of plaque and should prove useful for in vivo investigation of plaque growth and plaque suppression, where measurements of high quality is of importance.

Iterative Integration of Visual Insights during Scalable Patent Search and Analysis.

PubMed

Koch, S; Bosch, H; Giereth, M; Ertl, T

2011-05-01

Patents are of growing importance in current economic markets. Analyzing patent information has, therefore, become a common task for many interest groups. As a prerequisite for patent analysis, extensive search for relevant patent information is essential. Unfortunately, the complexity of patent material inhibits a straightforward retrieval of all relevant patent documents and leads to iterative, time-consuming approaches in practice. Already the amount of patent data to be analyzed poses challenges with respect to scalability. Further scalability issues arise concerning the diversity of users and the large variety of analysis tasks. With "PatViz", a system for interactive analysis of patent information has been developed addressing scalability at various levels. PatViz provides a visual environment allowing for interactive reintegration of insights into subsequent search iterations, thereby bridging the gap between search and analytic processes. Because of its extensibility, we expect that the approach we have taken can be employed in different problem domains that require high quality of search results regarding their completeness.

Stability of Cell Wall Composition and Saccharification Efficiency in Miscanthus across Diverse Environments

PubMed Central

van der Weijde, Tim; Dolstra, Oene; Visser, Richard G. F.; Trindade, Luisa M.

2017-01-01

To investigate the potential effects of differences between growth locations on the cell wall composition and saccharification efficiency of the bioenergy crop miscanthus, a diverse set of 15 accessions were evaluated in six locations across Europe for the first 3 years following establishment. High-throughput quantification of cellulose, hemicellulose and lignin contents, as well as cellulose and hemicellulose conversion rates was achieved by combining near-infrared reflectance spectroscopy (NIRS) and biochemical analysis. Prediction models were developed and found to predict biomass quality characteristics with high accuracy. Location significantly affected biomass quality characteristics in all three cultivation years, but location-based differences decreased toward the third year as the plants reached maturity and the effect of location-dependent differences in the rate of establishment reduced. In all locations extensive variation in accession performance was observed for quality traits. The performance of the different accessions in the second and third cultivation year was strongly correlated, while accession performance in the first cultivation year did not correlate well with performance in later years. Significant genotype-by-environment (G × E) interactions were observed for most traits, revealing differences between accessions in environmental sensitivity. Stability analysis of accession performance for calculated ethanol yields suggested that selection for good and stable performance is a viable approach. Environmental influence on biomass quality is substantial and should be taken into account in order to match genotype, location and end-use of miscanthus as a lignocellulose feedstock. PMID:28111583

Stability of Cell Wall Composition and Saccharification Efficiency in Miscanthus across Diverse Environments.

PubMed

van der Weijde, Tim; Dolstra, Oene; Visser, Richard G F; Trindade, Luisa M

2016-01-01

To investigate the potential effects of differences between growth locations on the cell wall composition and saccharification efficiency of the bioenergy crop miscanthus, a diverse set of 15 accessions were evaluated in six locations across Europe for the first 3 years following establishment. High-throughput quantification of cellulose, hemicellulose and lignin contents, as well as cellulose and hemicellulose conversion rates was achieved by combining near-infrared reflectance spectroscopy (NIRS) and biochemical analysis. Prediction models were developed and found to predict biomass quality characteristics with high accuracy. Location significantly affected biomass quality characteristics in all three cultivation years, but location-based differences decreased toward the third year as the plants reached maturity and the effect of location-dependent differences in the rate of establishment reduced. In all locations extensive variation in accession performance was observed for quality traits. The performance of the different accessions in the second and third cultivation year was strongly correlated, while accession performance in the first cultivation year did not correlate well with performance in later years. Significant genotype-by-environment (G × E) interactions were observed for most traits, revealing differences between accessions in environmental sensitivity. Stability analysis of accession performance for calculated ethanol yields suggested that selection for good and stable performance is a viable approach. Environmental influence on biomass quality is substantial and should be taken into account in order to match genotype, location and end-use of miscanthus as a lignocellulose feedstock.

Association between socioeconomic factors and sleep quality in an urban population-based sample in Germany.

PubMed

Anders, Markus P; Breckenkamp, Jürgen; Blettner, Maria; Schlehofer, Brigitte; Berg-Beckhoff, Gabriele

2014-12-01

Good sleep quality is essential for recovery. The risk factors of sleep disorders have been extensively investigated, but there is sparse information on the association of socioeconomic factors with a person's sleep quality. The aim of the present analysis is to investigate this association, taking particularly the effect of health confounders into consideration. The data were extracted from the cross-sectional QUEBEB Study. In total, the study sample consisted of 3281 participants (1817 women and 1464 men, aged 16-72 years). Here socioeconomic status (SES) was collected from the baseline survey taken in 2004. Sleep quality for the same participants was measured with in-depth personal interviews in 2006 using the Pittsburgh Sleep Quality Index, together with other relevant characteristics (e.g. anxiety, depression and health status). Multiple logistic regression analyses were performed. People living in an urban environment with a high or medium SES have a greater probability of good sleep quality (odds ratio 1.65, 95% confidence interval 1.27-2.14; odds ratio 1.40, 95% confidence interval 1.16-1.69) than persons with a low SES. Anxiety and depression, but also health status, are also associated with sleep quality and can influence in part the socioeconomic levels seen in sleep quality. SES and sleep quality are associated. However, there are important additional determinants that influence the level of association between SES and sleep quality. Several factors, such as anxiety, depression and health status, are associated with poorer sleep quality, but at the same time, these factors occur more often within lower social classes. © The Author 2013. Published by Oxford University Press on behalf of the European Public Health Association. All rights reserved.

HeatmapGenerator: high performance RNAseq and microarray visualization software suite to examine differential gene expression levels using an R and C++ hybrid computational pipeline.

PubMed

Khomtchouk, Bohdan B; Van Booven, Derek J; Wahlestedt, Claes

2014-01-01

The graphical visualization of gene expression data using heatmaps has become an integral component of modern-day medical research. Heatmaps are used extensively to plot quantitative differences in gene expression levels, such as those measured with RNAseq and microarray experiments, to provide qualitative large-scale views of the transcriptonomic landscape. Creating high-quality heatmaps is a computationally intensive task, often requiring considerable programming experience, particularly for customizing features to a specific dataset at hand. Software to create publication-quality heatmaps is developed with the R programming language, C++ programming language, and OpenGL application programming interface (API) to create industry-grade high performance graphics. We create a graphical user interface (GUI) software package called HeatmapGenerator for Windows OS and Mac OS X as an intuitive, user-friendly alternative to researchers with minimal prior coding experience to allow them to create publication-quality heatmaps using R graphics without sacrificing their desired level of customization. The simplicity of HeatmapGenerator is that it only requires the user to upload a preformatted input file and download the publicly available R software language, among a few other operating system-specific requirements. Advanced features such as color, text labels, scaling, legend construction, and even database storage can be easily customized with no prior programming knowledge. We provide an intuitive and user-friendly software package, HeatmapGenerator, to create high-quality, customizable heatmaps generated using the high-resolution color graphics capabilities of R. The software is available for Microsoft Windows and Apple Mac OS X. HeatmapGenerator is released under the GNU General Public License and publicly available at: http://sourceforge.net/projects/heatmapgenerator/. The Mac OS X direct download is available at: http://sourceforge.net/projects/heatmapgenerator/files/HeatmapGenerator_MAC_OSX.tar.gz/download. The Windows OS direct download is available at: http://sourceforge.net/projects/heatmapgenerator/files/HeatmapGenerator_WINDOWS.zip/download.

Filling Gaps in Biogeochemical Understanding of Wildfire Effects on Watersheds and Water Quality

NASA Astrophysics Data System (ADS)

Rhoades, Charles; Covino, Timothy; Chow, Alex

2017-04-01

Large, high-severity wildfires alter the biogeochemical conditions that determine how watersheds retain and release nutrients and influence stream water quality. These effects are commonly expected to abate within a few years, but recent studies show that post-fire watershed changes can have persistent, but poorly-understood biogeochemical consequences. Owing to the increased frequency and extent of high-severity wildfires predicted for western North America, and the growing awareness of the links between wildfire and clean water supply, there is a need to address these knowledge gaps. For the past 15 years we have tracked stream nutrients, chemistry, temperature, and sediment after the 2002 Hayman Fire, the largest wildfire in Colorado history. Our earlier work showed that headwater catchments that experienced extensive, high-severity forest fires had elevated stream nitrate, temperature, and turbidity for five post-fire years. Recent sampling, conducted 13 and 14 years after the fire, found that turbidity had largely returned to pretreatment levels, but that stream nitrate remained an order of magnitude above pre-fire levels in catchments with extensive high-severity wildfire. Stream temperature and total dissolved nitrogen concentration also remained higher in those catchments compared to unburned streams. Decreased plant demand is the mechanism commonly credited for post-fire nutrient losses, though our current work is evaluating the implications of soil and stream nutrient uptake and supply on persistent nitrogen (N) export from severely-burned catchments. For example, we have measured higher total soil N and higher net N mineralization in severely-burned portions of the Hayman Fire compared to moderately or unburned areas, indicating that higher soil N supply may contribute to N losses from upland soils. Conversely, using a nutrient tracer approach we found reduced N uptake in burned streams, which suggests a switch from the N-limited conditions typical of pristine catchments. Low stream dissolved organic carbon (DOC) in severely-burned catchments suggests greater carbon limitation on in-stream biological activity. This is the likely result of organic matter losses during the wildfire compounded by low allochthonous inputs from uplands or riparian zones. We also find that catchments with severely-burned headwater reaches and sparse riparian vegetation have high stream nitrate. Our findings regarding soil N supply and in-stream N retention coupled with the persistent N losses from burned headwaters and exposed riparian zones help prioritize restoration efforts aimed at mitigating long-term water quality effects of severe wildfires.

A 3D high resolution ex vivo white matter atlas of the common squirrel monkey (saimiri sciureus) based on diffusion tensor imaging

NASA Astrophysics Data System (ADS)

Gao, Yurui; Parvathaneni, Prasanna; Schilling, Kurt G.; Wang, Feng; Stepniewska, Iwona; Xu, Zhoubing; Choe, Ann S.; Ding, Zhaohua; Gore, John C.; Chen, Li min; Landman, Bennett A.; Anderson, Adam W.

2016-03-01

Modern magnetic resonance imaging (MRI) brain atlases are high quality 3-D volumes with specific structures labeled in the volume. Atlases are essential in providing a common space for interpretation of results across studies, for anatomical education, and providing quantitative image-based navigation. Extensive work has been devoted to atlas construction for humans, macaque, and several non-primate species (e.g., rat). One notable gap in the literature is the common squirrel monkey - for which the primary published atlases date from the 1960's. The common squirrel monkey has been used extensively as surrogate for humans in biomedical studies, given its anatomical neuro-system similarities and practical considerations. This work describes the continued development of a multi-modal MRI atlas for the common squirrel monkey, for which a structural imaging space and gray matter parcels have been previously constructed. This study adds white matter tracts to the atlas. The new atlas includes 49 white matter (WM) tracts, defined using diffusion tensor imaging (DTI) in three animals and combines these data to define the anatomical locations of these tracks in a standardized coordinate system compatible with previous development. An anatomist reviewed the resulting tracts and the inter-animal reproducibility (i.e., the Dice index of each WM parcel across animals in common space) was assessed. The Dice indices range from 0.05 to 0.80 due to differences of local registration quality and the variation of WM tract position across individuals. However, the combined WM labels from the 3 animals represent the general locations of WM parcels, adding basic connectivity information to the atlas.

A 3D high resolution ex vivo white matter atlas of the common squirrel monkey (Saimiri sciureus) based on diffusion tensor imaging

PubMed Central

Gao, Yurui; Parvathaneni, Prasanna; Schilling, Kurt G.; Wang, Feng; Stepniewska, Iwona; Xu, Zhoubing; Choe, Ann S.; Ding, Zhaohua; Gore, John C.; Chen, Li Min; Landman, Bennett A.; Anderson, Adam W.

2016-01-01

Modern magnetic resonance imaging (MRI) brain atlases are high quality 3-D volumes with specific structures labeled in the volume. Atlases are essential in providing a common space for interpretation of results across studies, for anatomical education, and providing quantitative image-based navigation. Extensive work has been devoted to atlas construction for humans, macaque, and several non-primate species (e.g., rat). One notable gap in the literature is the common squirrel monkey – for which the primary published atlases date from the 1960’s. The common squirrel monkey has been used extensively as surrogate for humans in biomedical studies, given its anatomical neuro-system similarities and practical considerations. This work describes the continued development of a multi-modal MRI atlas for the common squirrel monkey, for which a structural imaging space and gray matter parcels have been previously constructed. This study adds white matter tracts to the atlas. The new atlas includes 49 white matter (WM) tracts, defined using diffusion tensor imaging (DTI) in three animals and combines these data to define the anatomical locations of these tracks in a standardized coordinate system compatible with previous development. An anatomist reviewed the resulting tracts and the inter-animal reproducibility (i.e., the Dice index of each WM parcel across animals in common space) was assessed. The Dice indices range from 0.05 to 0.80 due to differences of local registration quality and the variation of WM tract position across individuals. However, the combined WM labels from the 3 animals represent the general locations of WM parcels, adding basic connectivity information to the atlas. PMID:27064328

A 3D high resolution ex vivo white matter atlas of the common squirrel monkey (Saimiri sciureus) based on diffusion tensor imaging.

PubMed

Gao, Yurui; Parvathaneni, Prasanna; Schilling, Kurt G; Wang, Feng; Stepniewska, Iwona; Xu, Zhoubing; Choe, Ann S; Ding, Zhaohua; Gore, John C; Chen, Li Min; Landman, Bennett A; Anderson, Adam W

2016-02-27

Modern magnetic resonance imaging (MRI) brain atlases are high quality 3-D volumes with specific structures labeled in the volume. Atlases are essential in providing a common space for interpretation of results across studies, for anatomical education, and providing quantitative image-based navigation. Extensive work has been devoted to atlas construction for humans, macaque, and several non-primate species (e.g., rat). One notable gap in the literature is the common squirrel monkey - for which the primary published atlases date from the 1960's. The common squirrel monkey has been used extensively as surrogate for humans in biomedical studies, given its anatomical neuro-system similarities and practical considerations. This work describes the continued development of a multi-modal MRI atlas for the common squirrel monkey, for which a structural imaging space and gray matter parcels have been previously constructed. This study adds white matter tracts to the atlas. The new atlas includes 49 white matter (WM) tracts, defined using diffusion tensor imaging (DTI) in three animals and combines these data to define the anatomical locations of these tracks in a standardized coordinate system compatible with previous development. An anatomist reviewed the resulting tracts and the inter-animal reproducibility (i.e., the Dice index of each WM parcel across animals in common space) was assessed. The Dice indices range from 0.05 to 0.80 due to differences of local registration quality and the variation of WM tract position across individuals. However, the combined WM labels from the 3 animals represent the general locations of WM parcels, adding basic connectivity information to the atlas.

Nanoparticle Enhancement Cascade for Sensitive Multiplex Measurements of Biomarkers in Complex Fluids with Surface Plasmon Resonance Imaging.

PubMed

Hendriks, Jan; Stojanovic, Ivan; Schasfoort, Richard B M; Saris, Daniël B F; Karperien, Marcel

2018-06-05

There is a large unmet need for reliable biomarker measurement systems for clinical application. Such systems should meet challenging requirements for large scale use, including a large dynamic detection range, multiplexing capacity, and both high specificity and sensitivity. More importantly, these requirements need to apply to complex biological samples, which require extensive quality control. In this paper, we present the development of an enhancement detection cascade for surface plasmon resonance imaging (SPRi). The cascade applies an antibody sandwich assay, followed by neutravidin and a gold nanoparticle enhancement for quantitative biomarker measurements in small volumes of complex fluids. We present a feasibility study both in simple buffers and in spiked equine synovial fluid with four cytokines, IL-1β, IL-6, IFN-γ, and TNF-α. Our enhancement cascade leads to an antibody dependent improvement in sensitivity up to 40 000 times, resulting in a limit of detection as low as 50 fg/mL and a dynamic detection range of more than 7 logs. Additionally, measurements at these low concentrations are highly reliable with intra- and interassay CVs between 2% and 20%. We subsequently showed this assay is suitable for multiplex measurements with good specificity and limited cross-reactivity. Moreover, we demonstrated robust detection of IL-6 and IL-1β in spiked undiluted equine synovial fluid with small variation compared to buffer controls. In addition, the availability of real time measurements provides extensive quality control opportunities, essential for clinical applications. Therefore, we consider this method is suitable for broad application in SPRi for multiplex biomarker detection in both research and clinical settings.

Upgrading plant amino acids through cattle to improve the nutritional value for humans: effects of different production systems.

PubMed

Patel, M; Sonesson, U; Hessle, A

2017-03-01

Efficiency in animal protein production can be defined in different ways, for example the amount of human-digestible essential amino acids (HDEAA) in the feed ration relative to the amount of HDEAA in the animal products. Cattle production systems are characterised by great diversity and a wide variety of feeds and feed ration compositions, due to ruminants' ability to digest fibrous materials inedible to humans such as roughage and by-products from the food and biofuel industries. This study examined the upgrading of protein quality through cattle by determining the quantity of HDEAA in feeds and animal products and comparing different milk and beef production systems. Four different systems for milk and beef production were designed, a reference production system for milk and beef representing typical Swedish production systems today and three alternative improved systems: (i) intensive cattle production based on maize silage, (ii) intensive systems based on food industry by-products for dairy cows and high-quality forage for beef cattle, and (iii) extensive systems based on forage with only small amounts of concentrate. In all four production systems, the quantity of HDEAA in the products (milk and meat) generally exceeded the quantity of HDEAA in the feeds. The intensive production models for beef calves generally resulted in output of the same magnitude as input for most HDEAA. However, in beef production based on calves from dairy cows, the intensive rearing systems resulted in lower output than input of HDEAA. For the extensive models, the amounts of HDEAA in meat were of the same magnitude as the amounts in the feeds. The extensive models with beef calves from suckler cows resulted in higher output in meat than input in feeds for all HDEAA. It was concluded that feeding cattle plants for production of milk and meat, instead of using the plants directly as human food, generally results in an upgrading of both the quantity and quality of protein, especially when extensive, forage-based production models are used. The results imply that the key to efficiency is the utilisation of human-inedible protein by cattle and justifies their contribution to food production, especially in regions where grasslands and/or forage production has comparative benefits over plant food production. By fine-tuning estimation of the efficiency of conversion from human-edible protein to HDEAA, comparisons of different sources of protein production may be more complete and the magnitude of amino acid upgrading in plants through cattle more obvious.

Bread Wheat Quality: Some Physical, Chemical and Rheological Characteristics of Syrian and English Bread Wheat Samples.

PubMed

Al-Saleh, Abboud; Brennan, Charles S

2012-11-22

The relationships between breadmaking quality, kernel properties (physical and chemical), and dough rheology were investigated using flours from six genotypes of Syrian wheat lines, comprising both commercially grown cultivars and advanced breeding lines. Genotypes were grown in 2008/2009 season in irrigated plots in the Eastern part of Syria. Grain samples were evaluated for vitreousness, test weight, 1000-kernel weight and then milled and tested for protein content, ash, and water content. Dough rheology of the samples was studied by the determination of the mixing time, stability, weakness, resistance and the extensibility of the dough. Loaf baking quality was evaluated by the measurement of the specific weight, resilience and firmness in addition to the sensory analysis. A comparative study between the six Syrian wheat genotypes and two English flour samples was conducted. Significant differences were observed among Syrian genotypes in vitreousness (69.3%-95.0%), 1000-kernel weight (35.2-46.9 g) and the test weight (82.2-88.0 kg/hL). All samples exhibited high falling numbers (346 to 417 s for the Syrian samples and 285 and 305 s for the English flours). A significant positive correlation was exhibited between the protein content of the flour and its absorption of water (r = 0.84 **), as well as with the vitreousness of the kernel (r = 0.54 *). Protein content was also correlated with dough stability (r = 0.86 **), extensibility (r = 0.8 **), and negatively correlated with dough weakness (r = -0.69 **). Bread firmness and dough weakness were positively correlated (r = 0.66 **). Sensory analysis indicated Doumah-2 was the best appreciated whilst Doumah 40765 and 46055 were the least appreciated which may suggest their suitability for biscuit preparation rather than bread making.

Bread Wheat Quality: Some Physical, Chemical and Rheological Characteristics of Syrian and English Bread Wheat Samples

PubMed Central

Al-Saleh, Abboud; Brennan, Charles S.

2012-01-01

The relationships between breadmaking quality, kernel properties (physical and chemical), and dough rheology were investigated using flours from six genotypes of Syrian wheat lines, comprising both commercially grown cultivars and advanced breeding lines. Genotypes were grown in 2008/2009 season in irrigated plots in the Eastern part of Syria. Grain samples were evaluated for vitreousness, test weight, 1000-kernel weight and then milled and tested for protein content, ash, and water content. Dough rheology of the samples was studied by the determination of the mixing time, stability, weakness, resistance and the extensibility of the dough. Loaf baking quality was evaluated by the measurement of the specific weight, resilience and firmness in addition to the sensory analysis. A comparative study between the six Syrian wheat genotypes and two English flour samples was conducted. Significant differences were observed among Syrian genotypes in vitreousness (69.3%–95.0%), 1000-kernel weight (35.2–46.9 g) and the test weight (82.2–88.0 kg/hL). All samples exhibited high falling numbers (346 to 417 s for the Syrian samples and 285 and 305 s for the English flours). A significant positive correlation was exhibited between the protein content of the flour and its absorption of water (r = 0.84 **), as well as with the vitreousness of the kernel (r = 0.54 *). Protein content was also correlated with dough stability (r = 0.86 **), extensibility (r = 0.8 **), and negatively correlated with dough weakness (r = −0.69 **). Bread firmness and dough weakness were positively correlated (r = 0.66 **). Sensory analysis indicated Doumah-2 was the best appreciated whilst Doumah 40765 and 46055 were the least appreciated which may suggest their suitability for biscuit preparation rather than bread making. PMID:28239087

Evaluation of long term health-related quality of life in extensive burns: a 12-year experience in a burn center.

PubMed

Xie, Bing; Xiao, Shi-chu; Zhu, Shi-hui; Xia, Zhao-fan

2012-05-01

We sought to evaluate the long term health-related quality of life (HRQOL) in patients survived severely extensive burn and identify their clinical predicting factors correlated with HRQOL. A cross-sectional study was conducted in 20 patients survived more than 2 years with extensive burn involving ≥70% total body surface area (TBSA) between 1997 and 2009 in a burn center in Shanghai. Short Form-36 Medical Outcomes Survey (SF-36), Brief Version of Burn Specific Health Scale (BSHS-B) and Michigan Hand Outcome Questionnaire (MHQ) were used for the present evaluation. SF-36 scores were compared with a healthy Chinese population, and linear correlation analysis was performed to screen the clinical relating factors predicting physical and mental component summary (PCS and MCS) scores from SF-36. HRQOL scores from SF-36 were significantly lower in the domains of physical functioning, role limitations due to physical problems, pain, social functioning and role limitations due to emotional problems compared with population norms. Multiple linear regression analysis demonstrated that only return to work (RTW) predicted improved PCS. While age at injury, facial burns, skin grafting and length of hospital stay were correlated with MCS. Work, body image and heat sensitivity obtained the lowest BSHS-B scores in all 9 domains. Improvements of HRQOL could still be seen in BSHS-B scores in domains of simple abilities, hand function, work and affect even after a quite long interval between burns and testing. Hand function of extensive burn patients obtained relatively poor MHQ scores, especially in those without RTW. Patients with extensive burns have a poorer quality of life compared with that of general population. Relatively poor physical and psychological problems still exist even after a long period. Meanwhile, a trend of gradual improvements was noted. This information will aid clinicians in decision-making of comprehensive systematic regimens for long term rehabilitation and psychosocial treatment. Copyright © 2011 Elsevier Ltd and ISBI. All rights reserved.

"Martian Boneyards": Sustained Scientific Inquiry in a Social Digital Game

NASA Astrophysics Data System (ADS)

Asbell-Clarke, Jordis

Social digital gaming is an explosive phenomenon where youth and adults are engaged in inquiry for the sake of fun. The complexity of learning evidenced in social digital games is attracting the attention of educators. Martian Boneyards is a proof-of-concept game designed to study how a community of voluntary gamers can be enticed to engage in sustained, high-quality scientific inquiry. Science educators and game designers worked together to create an educational game with the polish and intrigue of a professional-level game, striving to attract a new audience to scientific inquiry. Martian Boneyards took place in the high-definition, massively multiplayer online environment, Blue Mars, where players spent an average of 30 hours in the game over the 4-month implementation period, with some exceeding 200 hours. Most of the players' time was spent in scientific inquiry activities and about 30% of the players' in-game interactions were in the analysis and theory-building phases of inquiry. Female players conducted most of the inquiry, in particular analysis and theory building. The quality of scientific inquiry processes, which included extensive information gathering by players, and the resulting content were judged to be very good by a team of independent scientists. This research suggests that a compelling storyline, a highly aesthetic environment, and the emergent social bonds among players and between players and the characters played by designers were all responsible for sustaining high quality inquiry among gamers in this free-choice experience. The gaming environment developed for Martian Boneyards is seen as an evolving ecosystem with interactions among design, players' activity, and players' progress.

Effect of Ozone Treatment on Deoxynivalenol and Wheat Quality

PubMed Central

Wang, Li; Shao, Huili; Luo, Xiaohu; Wang, Ren; Li, Yongfu; Li, Yanan; Luo, Yingpeng; Chen, Zhengxing

2016-01-01

Deoxynivalenol (DON) is a secondary metabolite produced by Fusarium fungi, which is found in a wide range of agricultural products, especially in wheat, barley, oat and corn. In this study, the distribution of DON in the wheat kernel and the effect of exposure time to ozone on DON detoxification were investigated. A high concentration of toxin was found in the outer part of the kernel, and DON was injected from the outside to the inside. The degradation rates of DON were 26.40%, 39.16%, and 53.48% after the samples were exposed to 75 mg/L ozone for 30, 60, and 90 min, respectively. The effect of ozonation on wheat flour quality and nutrition was also evaluated. No significant differences (P > 0.05) were found in protein content, fatty acid value, amino acid content, starch content, carbonyl and carboxyl content, and swelling power of ozone-treated samples. Moreover, the ozone-treated samples exhibited higher tenacity and whiteness, as well as lower extensibility and yellowness. This finding indicated that ozone treatment can simultaneously reduce DON levels and improve flour quality. PMID:26812055

Assessing background ground water chemistry beneath a new unsewered subdivision

USGS Publications Warehouse

Wilcox, J.D.; Bradbury, K.R.; Thomas, C.L.; Bahr, J.M.

2005-01-01

Previous site-specific studies designed to assess the impacts of unsewered subdivisions on ground water quality have relied on upgradient monitoring wells or very limited background data to characterize conditions prior to development. In this study, an extensive monitoring program was designed to document ground water conditions prior to construction of a rural subdivision in south-central Wisconsin. Previous agricultural land use has impacted ground water quality; concentrations of chloride, nitrate-nitrogen, and atrazine ranged from below the level of detection to 296 mg/L, 36 mg/L, and 0.8 ??g/L, respectively, and were highly variable from well to well and through time. Seasonal variations in recharge, surface topography, aquifer heterogeneities, surficial loading patterns, and well casing depth explain observed variations in ground water chemistry. This variability would not have been detected if background conditions were determined from only a few monitoring wells or inferred from wells located upgradient of the subdivision site. This project demonstrates the importance of characterizing both ground water quality and chemical variability prior to land-use change to detect any changes once homes are constructed. Copyright ?? 2005 National Ground Water Association.

Food structure: Its formation and relationships with other properties.

PubMed

Joardder, Mohammad U H; Kumar, Chandan; Karim, M A

2017-04-13

Food materials are complex in nature as it has heterogeneous, amorphous, hygroscopic and porous properties. During processing, microstructure of food materials changes which significantly affects other properties of food. An appropriate understanding of the microstructure of the raw food material and its evolution during processing is critical in order to understand and accurately describe dehydration processes and quality anticipation. This review critically assesses the factors that influence the modification of microstructure in the course of drying of fruits and vegetables. The effect of simultaneous heat and mass transfer on microstructure in various drying methods is investigated. Effects of changes in microstructure on other functional properties of dried foods are discussed. After an extensive review of the literature, it is found that development of food structure significantly depends on fresh food properties and process parameters. Also, modification of microstructure influences the other properties of final product. An enhanced understanding of the relationships between food microstructure, drying process parameters and final product quality will facilitate the energy efficient optimum design of the food processor in order to achieve high-quality food.

Wedding Rigorous Scientific Methodology and Ancient Herbal Wisdom to Benefit Cancer Patients: The Development of PHY906.

PubMed

Chu, Edward

2018-02-15

Our research group has extensively characterized the preclinical and clinical activities of PHY906, a traditional Chinese herbal medicine, as a modulator of irinotecan-based chemotherapy for the treatment of colorectal cancer. This article reviews the critical issues of quality control and standardization of PHY906 and highlights the importance of high-quality material for the conduct of preclinical and clinical studies. Studies to investigate the potential biological mechanisms of action using a systems biology approach play a pivotal role in providing the preclinical rationale to move forward with clinical studies. For early-phase clinical studies, translational biomarkers should be incorporated to characterize the biological effects of the herbal medicine. These biomarkers include tumor mutational load, cytokine/chemokine expression, metabolomic profiling, and the presence of key herbal metabolites. Sophisticated bioinformatic approaches are critical for mining the data and identifying those biomarkers that can define the subset of patients who will benefit from PHY906 or any other herbal medicine, in terms of reduced treatment toxicity, improved quality of life, and/or enhanced clinical activity of treatment.

Spatial patterns of chemical contamination (metals, PAHs, PCBs, PCDDs/PCDFS) in sediments of a non-industrialized but densely populated coral atoll/small island state (Bermuda).

PubMed

Jones, Ross J

2011-06-01

There is a recognized dearth of standard environmental quality data in the wider Caribbean area, especially on coral atolls/small island states. Extensive surveys of sediment contamination (n=109 samples) in Bermuda revealed a wide spectrum of environmental quality. Zinc and especially copper levels were elevated at some locations, associated with boating (antifouling paints and boatyard discharges). Mercury contamination was surprisingly prevalent, with total levels as high as 12mg kg(-1)DW, although methyl mercury levels were quite low. PAH, PCB and PCDD/PCDF contamination was detected a several hotspots associated with road run-off, a marine landfill, and a former US Naval annexe. NOAA sediment quality guidelines were exceeded at several locations, indicating biological effects are possible, or at some locations probable. Overall, and despite lack of industrialization, anthropogenic chemicals in sediments of the atoll presented a risk to benthic biodiversity at a number of hotspots suggesting a need for sediment management strategies. Copyright © 2011 Elsevier Ltd. All rights reserved.

Divergent growth strategies between red algae and kelps influence biomechanical properties.

PubMed

Krumhansl, Kira A; Demes, Kyle W; Carrington, Emily; Harley, Christopher D G

2015-11-01

Morphology and material properties are the main components of the mechanical design of organisms, with species groups developing different optimization strategies in the context of their physical environment. For intertidal and subtidal seaweeds, possessing highly flexible and extensible tissues allows individuals to bend and reconfigure in flow, thereby reducing drag. Previous research has shown that aging may compromise these qualities. Tissue age increases with distance from the blade's meristem, which differs in its position on kelps and red algae. Here, we assess whether longitudinal patterns of blade material properties differ between these two algal groups according to tissue age. We performed tensile tests on tissues samples excised from various positions along the extent of blades in nine kelp species (basal growth) and 15 species of red algae (apical growth). We found that older tissues were less flexible and extensible than younger tissues in all species tested. As predicted, tissue near the basal meristem in kelp was more flexible and extensible than older tissue at the blade's distal end. The opposite pattern was observed for red algae, with the most flexible and extensible tissues found near the apical meristem at the distal ends of blades. We propose that divergent patterns in the distribution of material properties along blades may have different consequences for the performance of kelps and red algae. The positioning of younger tissues at the blade base for kelps may enable these species to attain larger body sizes in wave-swept habitats. © 2015 Botanical Society of America.

Cervical spine collar clearance in the obtunded adult blunt trauma patient: a systematic review and practice management guideline from the Eastern Association for the Surgery of Trauma.

PubMed

Patel, Mayur B; Humble, Stephen S; Cullinane, Daniel C; Day, Matthew A; Jawa, Randeep S; Devin, Clinton J; Delozier, Margaret S; Smith, Lou M; Smith, Miya A; Capella, Jeannette M; Long, Andrea M; Cheng, Joseph S; Leath, Taylor C; Falck-Ytter, Yngve; Haut, Elliott R; Como, John J

2015-02-01

With the use of the framework advocated by the Grading of Recommendations Assessment, Development and Evaluation (GRADE) Working Group, our aims were to perform a systematic review and to develop evidence-based recommendations that may be used to answer the following PICO [Population, Intervention, Comparator, Outcomes] question:In the obtunded adult blunt trauma patient, should cervical collar removal be performed after a negative high-quality cervical spine (C-spine) computed tomography (CT) result alone or after a negative high-quality C-spine CT result combined with adjunct imaging, to reduce peri-clearance events, such as new neurologic change, unstable C-spine injury, stable C-spine injury, need for post-clearance imaging, false-negative CT imaging result on re-review, pressure ulcers, and time to cervical collar clearance? Our protocol was registered with the PROSPERO international prospective register of systematic reviews on August 23, 2013 (REGISTRATION NUMBER: CRD42013005461). Eligibility criteria consisted of adult blunt trauma patients 16 years or older, who underwent C-spine CT with axial thickness of less than 3 mm and who were obtunded using any definition.Quantitative synthesis via meta-analysis was not possible because of pre-post, partial-cohort, quasi-experimental study design limitations and the consequential incomplete diagnostic accuracy data. Of five articles with a total follow-up of 1,017 included subjects, none reported new neurologic changes (paraplegia or quadriplegia) after cervical collar removal. There is a worst-case 9% (161 of 1,718 subjects in 11 studies) cumulative literature incidence of stable injuries and a 91% negative predictive value of no injury, after coupling a negative high-quality C-spine CT result with 1.5-T magnetic resonance imaging, upright x-rays, flexion-extension CT, and/or clinical follow-up. Similarly, there is a best-case 0% (0 of 1,718 subjects in 11 studies) cumulative literature incidence of unstable injuries after negative initial imaging result with a high-quality C-spine CT. In obtunded adult blunt trauma patients, we conditionally recommend cervical collar removal after a negative high-quality C-spine CT scan result alone. Systematic review, level III.

Sustainable management of harbours : a numerical approach for the assessment of waters quality

NASA Astrophysics Data System (ADS)

Bonamano, Simone; Madonia, Alice; Piazzolla, Daniele; Paladini de Mendoza, Francesco; Piermattei, Viviana; Scanu, Sergio; Melchiorri, Cristiano; Marcelli, Marco

2017-04-01

Within the Water Framework Directive (WFD), harbours must reach or maintain the good ecological potential, being classified as heavily modified water bodies. To fulfill this task and to comply the Marine Spatial Planning (MSP) principles, port managers have to monitor the water quality that can be compromised by the numerous activities including the realization of new infrastructures. The port of Civitavecchia, located on the central west coast of Italy, is undergoing to major structural changes to become one of the first ports of the Mediterranean in terms of passenger traffic and goods, thus requiring the development of management tools for the predictive assessment of harbour water quality. This study focused on the evaluation of water degradation within Civitavecchia port trough the calculation of Flushing time (FT) and the development of the new Flushing Efficiency Index (FEI). FT was calculated through the use of a numerical model under different scenarios selected combining different weather conditions with the new port configurations. FT values was then used to estimate the FEI for the evaluation of the improvement (positive values) or the deterioration (negative values) of water quality in the different zones of the port. The increase in the harbour basin size due to the embankment extension results in high values of FT, particularly in the inner part of the port, in accordance with the highest values of the Enrichment Factor (EF) of the trace metals found in the sediment. The correlation between FT and EF confirms that renewal time can be used as a proxy to evaluate the water quality conditions in the harbour basin, as also stated by the WFD guidelines. Also the results of FEI calculation indicate the potential occurrence of water degradation due to the embankment extension. Otherwise, the realization of a second entrance in the southern part of Civitavecchia port produces FEI positive values, highlighting a drastic improvement in harbour water renewal. Consistent with Blue Growth and Bluemed initiatives, the new tools developed in this study support the sustainable management of port activities, thereby also contributing to the development of new "blue jobs."

Improved quantification of important beer quality parameters based on nonlinear calibration methods applied to FT-MIR spectra.

PubMed

Cernuda, Carlos; Lughofer, Edwin; Klein, Helmut; Forster, Clemens; Pawliczek, Marcin; Brandstetter, Markus

2017-01-01

During the production process of beer, it is of utmost importance to guarantee a high consistency of the beer quality. For instance, the bitterness is an essential quality parameter which has to be controlled within the specifications at the beginning of the production process in the unfermented beer (wort) as well as in final products such as beer and beer mix beverages. Nowadays, analytical techniques for quality control in beer production are mainly based on manual supervision, i.e., samples are taken from the process and analyzed in the laboratory. This typically requires significant lab technicians efforts for only a small fraction of samples to be analyzed, which leads to significant costs for beer breweries and companies. Fourier transform mid-infrared (FT-MIR) spectroscopy was used in combination with nonlinear multivariate calibration techniques to overcome (i) the time consuming off-line analyses in beer production and (ii) already known limitations of standard linear chemometric methods, like partial least squares (PLS), for important quality parameters Speers et al. (J I Brewing. 2003;109(3):229-235), Zhang et al. (J I Brewing. 2012;118(4):361-367) such as bitterness, citric acid, total acids, free amino nitrogen, final attenuation, or foam stability. The calibration models are established with enhanced nonlinear techniques based (i) on a new piece-wise linear version of PLS by employing fuzzy rules for local partitioning the latent variable space and (ii) on extensions of support vector regression variants (-PLSSVR and ν-PLSSVR), for overcoming high computation times in high-dimensional problems and time-intensive and inappropriate settings of the kernel parameters. Furthermore, we introduce a new model selection scheme based on bagged ensembles in order to improve robustness and thus predictive quality of the final models. The approaches are tested on real-world calibration data sets for wort and beer mix beverages, and successfully compared to linear methods, showing a clear out-performance in most cases and being able to meet the model quality requirements defined by the experts at the beer company. Figure Workflow for calibration of non-Linear model ensembles from FT-MIR spectra in beer production .

Evaluating the Quality and Readability of Internet Information on Meningiomas.

PubMed

Saeed, Fozia; Anderson, Ian

2017-01-01

The Internet is a highly powerful resource for patients and provides an extensive amount of information on medical conditions. It is therefore important that the information accessible is accurate, up to date, and at an appropriate comprehensive level for the general public. This article aims to evaluate the quality of patient information on meningiomas. The term meningioma was searched using the following search engines: Google, Bing, Yahoo, Ask, and AOL. The top 100 meningioma Web sites were analyzed for readability using the Flesch Reading Ease score and the Flesch-Kincaid grade level. The quality of each Web page was assessed with the DISCERN instrument and the Centers for Disease Control and Prevention (CDC) Clear Communication Index (CCI). The quality of information on the Internet on meningiomas is highly variable. The overall mean Flesch Reading Ease score was 43.1 (standard deviation = 13.3) and the mean Flesch-Kincaid grade of all the Web sites was 11.2 (standard deviation = 2.3). This finding suggests that the information is on average difficult to read. Only one Web site was at the recommended seventh-grade level and the remainder were above this grade. Only one third of the Web pages had Health On the Net Code of Conduct or The Information Standard certification and were found to be significantly of higher quality: DISCERN (P = 0.022) and CDC CCI (P = 0.027). More than 50% of the Web sites had significantly poor or average DISCERN scores and only 2 Web sites fulfilled the CDC CCI criteria. It is recommended that clinicians personally research material for their patients to be able to guide them to reliable and accurate Web sites. It is also encouraged to become Health On the Net Code of Conduct/The Information Standard certified because this may indicate information of high quality. In addition, it is also recommended that authors of existing information assess the quality of their online health information against the CDC CCI criteria. Crown Copyright © 2016. Published by Elsevier Inc. All rights reserved.

Tuning the Curie temperature of epitaxial Nd0.6Sr0.4MnO3 thin films

NASA Astrophysics Data System (ADS)

Bhat, Shwetha G.; Kumar, P. S. Anil

2018-02-01

NdxSr1-xMnO3 (0.2 ≤ x ≤ 0.5) systems are widely studied in magnetism, popular for high colossal magnetoresistance and are ferromagnetic oxides with TC ranging from 200 K to 300 K. Recently, many of such compounds are re-visited for exploring the correlation of spin, charge and lattice degrees of freedom. Although, manganite thin films are the ideal candidates for studying the electron-correlation effects, the puzzle of obtaining a high quality epitaxial thin films of NdxSr1-xMnO3 are still unsolved contrary to its sister compound LaxSr1-xMnO3. Hence, in this study, we demonstrate the growth of best quality of Nd0.6Sr0.4MnO3 (NSMO) epitaxial thin films. This is evident from the TC and a sharp insulator-to-metal transition (IMT) coinciding at as high as ∼255 K against the bulk TC (∼270 K). It is the highest reported TC in Nd0.6Sr0.4MnO3 thin films to date. Moreover, as-deposited films with in situ oxygen annealing are not enough to relax the lattice of NSMO films due to the significant Jahn-Teller distortion in the film. With ex situ annealing processes alongside the various deposition and in situ annealing conditions, we have extensively studied the growth of epitaxial NSMO thin films on LaAlO3 (0 0 1) and SrTiO3 (0 0 1) to investigate the evolution of lattice and its one-to-one correspondence with the magnetism and the electrical properties of thin films. Accordingly, the enhanced magnetization, reduced resistivity and the higher TC and IMT of the NSMO films obtained from our extensive growth analysis looks promising for the future applications across the TC and IMT.

Optimizing screening for tuberculosis and hepatitis B prior to starting tumor necrosis factor-α inhibitors in Crohn's disease.

PubMed

van der Have, Mike; Oldenburg, Bas; Fidder, Herma H; Belderbos, Tim D G; Siersema, Peter D; van Oijen, Martijn G H

2014-03-01

Treatment with tumor necrosis factor-α (TNF-α) inhibitors in patients with Crohn's disease (CD) is associated with potentially serious infections, including tuberculosis (TB) and hepatitis B virus (HBV). We assessed the cost-effectiveness of extensive TB screening and HBV screening prior to initiating TNF-α inhibitors in CD. We constructed two Markov models: (1) comparing tuberculin skin test (TST) combined with chest X-ray (conventional TB screening) versus TST and chest X-ray followed by the interferon-gamma release assay (extensive TB screening) in diagnosing TB; and (2) HBV screening versus no HBV screening. Our base-case included an adult CD patient starting with infliximab treatment. Input parameters were extracted from the literature. Direct medical costs were assessed and discounted following a third-party payer perspective. The main outcome was the incremental cost-effectiveness ratio (ICER). Sensitivity and Monte Carlo analyses were performed over wide ranges of probability and cost estimates. At base-case, the ICERs of extensive screening and HBV screening were €64,340 and €75,760 respectively to gain one quality-adjusted life year. Sensitivity analyses concluded that extensive TB screening was a cost-effective strategy if the latent TB prevalence is more than 12 % or if the false positivity rate of TST is more than 20 %. HBV screening became cost-effective if HBV reactivation or HBV-related mortality is higher than 37 and 62 %, respectively. Extensive TB screening and HBV screening are not cost-effective compared with conventional TB screening and no HBV screening, respectively. However, when targeted at high-risk patient groups, these screening strategies are likely to become cost-effective.

Compression performance of HEVC and its format range and screen content coding extensions

NASA Astrophysics Data System (ADS)

Li, Bin; Xu, Jizheng; Sullivan, Gary J.

2015-09-01

This paper presents a comparison-based test of the objective compression performance of the High Efficiency Video Coding (HEVC) standard, its format range extensions (RExt), and its draft screen content coding extensions (SCC). The current dominant standard, H.264/MPEG-4 AVC, is used as an anchor reference in the comparison. The conditions used for the comparison tests were designed to reflect relevant application scenarios and to enable a fair comparison to the maximum extent feasible - i.e., using comparable quantization settings, reference frame buffering, intra refresh periods, rate-distortion optimization decision processing, etc. It is noted that such PSNR-based objective comparisons generally provide more conservative estimates of HEVC benefit than are found in subjective studies. The experimental results show that, when compared with H.264/MPEG-4 AVC, HEVC version 1 provides a bit rate savings for equal PSNR of about 23% for all-intra coding, 34% for random access coding, and 38% for low-delay coding. This is consistent with prior studies and the general characterization that HEVC can provide about a bit rate savings of about 50% for equal subjective quality for most applications. The HEVC format range extensions provide a similar bit rate savings of about 13-25% for all-intra coding, 28-33% for random access coding, and 32-38% for low-delay coding at different bit rate ranges. For lossy coding of screen content, the HEVC screen content coding extensions achieve a bit rate savings of about 66%, 63%, and 61% for all-intra coding, random access coding, and low-delay coding, respectively. For lossless coding, the corresponding bit rate savings are about 40%, 33%, and 32%, respectively.

Towards a Predictive Model of Quality in Canadian Child Care Centers

ERIC Educational Resources Information Center

Goelman, Hillel; Forer, Barry; Kershaw, Paul; Doherty, Gillian; Lero, Donna; LaGrange, Annette

2006-01-01

This paper reports on the design, methodology, and results of a study of quality in 326 classrooms in 239 Canadian child care centers. This study, the largest and most extensive ever undertaken in Canada, used the Caregiver Interaction Scale (CIS) to rate the adult-child interactions in the classrooms and the Infant-Toddler Environment Rating…

ENHANCED STREAM WATER QUALITY MODELS QUAL2E AND QUAL2E-UNCAS: DOCUMENTATION AND USER MANUAL

EPA Science Inventory

The manual is a major revision of the original QUAL2E program documentation released in 1985. It includes a description of the recent modifications and improvements to the widely used water quality models QUAL-II and QUAL2E. The enhancements include an extensive capability for un...

Assessing the Long-Term Impacts of Water Quality Outreach and Education Efforts on Agricultural Landowners

ERIC Educational Resources Information Center

Jackson-Smith, Douglas B.; McEvoy, Jamie P.

2011-01-01

We assess the long-term effectiveness of outreach and education efforts associated with a water quality improvement project in a watershed located in northern Utah, USA. Conducted 15 years after the original project began, our research examines the lasting impacts of different extension activities on landowners' motivations to participate and…

Measuring the Effect of Tourism Services on Travelers' Quality of Life: Further Validation.

ERIC Educational Resources Information Center

Neal, Janet D.; Sirgy, M. Joseph; Uysal, Muzaffer

2004-01-01

lication and extension study provided additional validational support of the original tourism services satisfaction measure in relation to QOL-related measures.Neal, Sirgy and Uysal (1999) developed a model and a measure to capture the effect of tourism services on travelers' quality of life (QOL). They hypothesized that travelers' overall life…

Effect of immersion chilling and air chilling on texture quality and cook yield of chicken breast tenderlion deboned for hours postmortem

USDA-ARS?s Scientific Manuscript database

Boneless chicken breast fillets (pectoralis major) and tenderloins (pectoralis minor) are common poultry products in retail markets and are used extensively by restaurants and food service. Texture quality of these products could be impacted by poultry processing methods and parameters. Effects of c...

75 FR 2107 - Certain Cut-to-Length Carbon-Quality Steel Plate from the Republic of Korea: Extension of the...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-14

... DEPARTMENT OF COMMERCE International Trade Administration [A-580-836] Certain Cut-to-Length Carbon... preliminary results of the administrative review of the antidumping duty order on certain cut-to-length carbon.... See Certain Cut-to-Length Carbon-Quality Steel Plate From the Republic of Korea: Preliminary Results...

The Impact of Preprimary School on Primary School Achievement in Bangladesh

ERIC Educational Resources Information Center

Aboud, Frances E.; Hossain, Kamal

2011-01-01

Evidence was collected regarding changes over 3 years in the quality of a preprimary program in rural Bangladesh and differences in school achievement of children who did and did not attend. The quality of 30 preprimary schools was evaluated using the ECERS-R (Early Childhood Environment Rating Scale-Revised) and ECERS-E (-Extension). Results…

Bidirectional Associations between Sleep (Quality and Duration) and Psychosocial Functioning across the University Years

ERIC Educational Resources Information Center

Tavernier, Royette; Willoughby, Teena

2014-01-01

Despite extensive research on sleep and psychosocial functioning, an important gap within the literature is the lack of inquiry into the direction of effects between these 2 constructs. The purpose of the present 3-year longitudinal study was to examine bidirectional associations between sleep (quality and duration) and 3 indices of psychosocial…

A Journey of Surprises: Rivers Reveal Their Secrets to Idaho Students Researching Water Quality through Rigorous Scientific Inquiry.

ERIC Educational Resources Information Center

Boss, Suzie

2002-01-01

Idaho secondary students learn the scientific method through outdoor environmental projects related to water quality monitoring. A program trains teachers to design project-based learning and provides extensive followup support. Five-day summer workshops immerse teachers in the types of projects they will orchestrate with their own students.…