Proprioception Is Robust under External Forces

PubMed Central

Kuling, Irene A.; Brenner, Eli; Smeets, Jeroen B. J.

2013-01-01

Information from cutaneous, muscle and joint receptors is combined with efferent information to create a reliable percept of the configuration of our body (proprioception). We exposed the hand to several horizontal force fields to examine whether external forces influence this percept. In an end-point task subjects reached visually presented positions with their unseen hand. In a vector reproduction task, subjects had to judge a distance and direction visually and reproduce the corresponding vector by moving the unseen hand. We found systematic individual errors in the reproduction of the end-points and vectors, but these errors did not vary systematically with the force fields. This suggests that human proprioception accounts for external forces applied to the hand when sensing the position of the hand in the horizontal plane. PMID:24019959

Spin-oscillator model for the unzipping of biomolecules by mechanical force.

PubMed

Prados, A; Carpio, A; Bonilla, L L

2012-08-01

A spin-oscillator system models unzipping of biomolecules (such as DNA, RNA, or proteins) subject to an external force. The system comprises a macroscopic degree of freedom, represented by a one-dimensional oscillator, and internal degrees of freedom, represented by Glauber spins with nearest-neighbor interaction and a coupling constant proportional to the oscillator position. At a critical value F(c) of an applied external force F, the oscillator rest position (order parameter) changes abruptly and the system undergoes a first-order phase transition. When the external force is cycled at different rates, the extension given by the oscillator position exhibits a hysteresis cycle at high loading rates, whereas it moves reversibly over the equilibrium force-extension curve at very low loading rates. Under constant force, the logarithm of the residence time at the stable and metastable oscillator rest position is proportional to F-F(c) as in an Arrhenius law.

Application of dGNSS in Alpine Ski Racing: Basis for Evaluating Physical Demands and Safety

PubMed Central

Gilgien, Matthias; Kröll, Josef; Spörri, Jörg; Crivelli, Philip; Müller, Erich

2018-01-01

External forces, such as ground reaction force or air drag acting on athletes' bodies in sports, determine the sport-specific demands on athletes' physical fitness. In order to establish appropriate physical conditioning regimes, which adequately prepare athletes for the loads and physical demands occurring in their sports and help reduce the risk of injury, sport-and/or discipline-specific knowledge of the external forces is needed. However, due to methodological shortcomings in biomechanical research, data comprehensively describing the external forces that occur in alpine super-G (SG) and downhill (DH) are so far lacking. Therefore, this study applied new and accurate wearable sensor-based technology to determine the external forces acting on skiers during World Cup (WC) alpine skiing competitions in the disciplines of SG and DH and to compare these with those occurring in giant slalom (GS), for which previous research knowledge exists. External forces were determined using WC forerunners carrying a differential global navigation satellite system (dGNSS). Combining the dGNSS data with a digital terrain model of the snow surface and an air drag model, the magnitudes of ground reaction forces were computed. It was found that the applied methodology may not only be used to track physical demands and loads on athletes, but also to simultaneously investigate safety aspects, such as the effectiveness of speed control through increased air drag and ski–snow friction forces in the respective disciplines. Therefore, the component of the ground reaction force in the direction of travel (ski–snow friction) and air drag force were computed. This study showed that (1) the validity of high-end dGNSS systems allows meaningful investigations such as characterization of physical demands and effectiveness of safety measures in highly dynamic sports; (2) physical demands were substantially different between GS, SG, and DH; and (3) safety-related reduction of skiing speed might be most effectively achieved by increasing the ski–snow friction force in GS and SG. For DH an increase in the ski–snow friction force might be equally as effective as an increase in air drag force. PMID:29559918

Coupled loads analysis for Space Shuttle payloads

NASA Technical Reports Server (NTRS)

Eldridge, J.

1992-01-01

Described here is a method for determining the transient response of, and the resultant loads in, a system exposed to predicted external forces. In this case, the system consists of four racks mounted on the inside of a space station resource node module (SSRNMO) which is mounted in the payload bay of the space shuttle. The predicted external forces are forcing functions which envelope worst case forces applied to the shuttle during liftoff and landing. This analysis, called a coupled loads analysis, is used to couple the payload and shuttle models together, determine the transient response of the system, and then recover payload loads, payload accelerations, and payload to shuttle interface forces.

Investigation of a relationship between external force to shoulder and chest injury of WorldSID and THUMS in 32 km/h oblique pole side impact.

PubMed

Tanaka, Shinobu; Hayashi, Shigeki; Fukushima, Satoshi; Yasuki, Tsuyoshi

2013-01-01

This article describes the chest injury risk reduction effect of shoulder restraints using finite element (FE) models of the worldwide harmonized side impact dummy (WorldSID) and Total Human Model for Safety (THUMS) in an FE model 32 km/h oblique pole side impact. This research used an FE model of a mid-sized vehicle equipped with various combinations of curtain shield air bags, torso air bags, and shoulder restraint air bags. As occupant models, AM50 WorldSID and THUMS AM50 Version 4 were used for comparison. The research investigated the effect of shoulder restraint air bag on chest injury by comparing cases with and without a shoulder side air bag. The maximum external force to the chest was reduced by shoulder restraint air bag in both WorldSID and THUMS, reducing chest injury risk as measured by the amount of rib deflection, number of the rib fractures, and rib deflection ratio. However, it was also determined that the external force to shoulder should be limited to the chest injury threshold because the external shoulder force transmits to the chest via the arm in the case of WorldSID and via the scapula in the case of THUMS. Because these results show the shoulder restraint air bag effect on chest injury risk, the vent hole size of the shoulder restraint air bag was changed for varying reaction forces to investigate the relationship between the external force to the shoulder and the risk of chest injury. In the case of THUMS, an external shoulder force of 1.8 kN and more force from the shoulder restraint air bag was necessary to help prevent rib fracture. Increasing external force applied to shoulder up to 6.2 kN (the maximum force used in this study) did not induce any rib or clavicle fractures in the THUMS. When the shoulder restraint air bag generated external force to the shoulder from 1.8 to 6.2 kN in THUMS, which were applied to the WorldSID, the shoulder deflection ranged from 35 to 68 mm, and the shoulder force ranged from 1.8 to 2.3 kN. In the test configuration used, a shoulder restraint using the air bag helps reduce chest injury risk by lowering the maximum magnitude of external force to the shoulder and chest. To help reduce rib fracture risk in the THUMS, the shoulder restraint air bag was expected to generate a force of 3.7 kN with a minimum rib deflection ratio. This corresponds to a shoulder rib deflection of 60 mm and a shoulder load of 2.2 kN in WorldSID. Supplemental materials are available for this article. Go to the publisher's online edition of Traffic Injury Prevention to view the supplemental file.

Muscle contributions to propulsion and braking during walking and running: insight from external force perturbations.

PubMed

Ellis, Richard G; Sumner, Bonnie J; Kram, Rodger

2014-09-01

There remains substantial debate as to the specific contributions of individual muscles to center of mass accelerations during walking and running. To gain insight, we altered the demand for muscular propulsion and braking by applying external horizontal impeding and aiding forces near the center of mass as subjects walked and ran on a treadmill. We recorded electromyographic activity of the gluteus maximus (superior and inferior portions), the gluteus medius, biceps femoris, semitendinosus/membrinosus, vastus medialis, lateral and medial gastrocnemius and soleus. We reasoned that activity in a propulsive muscle would increase with external impeding force and decrease with external aiding force whereas activity in a braking muscle would show the opposite. We found that during walking the gastrocnemius and gluteus maximus provide propulsion while the vasti are central in providing braking. During running, we found that the gluteus maximus, vastus medialis, gastrocnemius and soleus all contribute to propulsion. Copyright © 2014 Elsevier B.V. All rights reserved.

Selective structural source identification

NASA Astrophysics Data System (ADS)

Totaro, Nicolas

2018-04-01

In the field of acoustic source reconstruction, the inverse Patch Transfer Function (iPTF) has been recently proposed and has shown satisfactory results whatever the shape of the vibrating surface and whatever the acoustic environment. These two interesting features are due to the virtual acoustic volume concept underlying the iPTF methods. The aim of the present article is to show how this concept of virtual subsystem can be used in structures to reconstruct the applied force distribution. Some virtual boundary conditions can be applied on a part of the structure, called virtual testing structure, to identify the force distribution applied in that zone regardless of the presence of other sources outside the zone under consideration. In the present article, the applicability of the method is only demonstrated on planar structures. However, the final example show how the method can be applied to a complex shape planar structure with point welded stiffeners even in the tested zone. In that case, if the virtual testing structure includes the stiffeners the identified force distribution only exhibits the positions of external applied forces. If the virtual testing structure does not include the stiffeners, the identified force distribution permits to localize the forces due to the coupling between the structure and the stiffeners through the welded points as well as the ones due to the external forces. This is why this approach is considered here as a selective structural source identification method. It is demonstrated that this approach clearly falls in the same framework as the Force Analysis Technique, the Virtual Fields Method or the 2D spatial Fourier transform. Even if this approach has a lot in common with these latters, it has some interesting particularities like its low sensitivity to measurement noise.

Robot gripper

NASA Technical Reports Server (NTRS)

Webb, Winston S. (Inventor)

1987-01-01

An electronic force-detecting robot gripper for gripping objects and attaching to an external robot arm is disclosed. The gripper comprises motor apparatus, gripper jaws, and electrical circuits for driving the gripper motor and sensing the amount of force applied by the jaws. The force applied by the jaws is proportional to a threshold value of the motor current. When the motor current exceeds the threshold value, the electrical circuits supply a feedback signal to the electrical control circuit which, in turn, stops the gripper motor.

Bracing of pectus carinatum: A quantitative analysis.

PubMed

Bugajski, Tomasz; Murari, Kartikeya; Lopushinsky, Steven; Schneider, Marc; Ronsky, Janet

2018-05-01

Primary treatment of pectus carinatum (PC) is performed with an external brace that compresses the protrusion. Patients are 'prescribed' a brace tightening force. However, no visual guides exist to display this force magnitude. The purpose of this study was to determine the repeatability of patients in applying their prescribed force over time and to determine whether the protrusion stiffness influences the patient-applied forces and the protrusion correction rate. Twenty-one male participants (12-17years) with chondrogladiolar PC were recruited at the time of brace fitting. Participants were evaluated on three visits: fitting, one month postfitting, and two months postfitting. Differences between prescribed force and patient-applied force were evaluated. Relationships of patient-applied force and correction rate with protrusion stiffness were assessed. Majority of individuals followed for two months (75%) had a significantly different patient-applied force (p<0.05) from their prescribed force. Protrusion stiffness had a positive relationship with patient-applied force, but no relationship with correction rate. Patients did not follow their prescribed force. Magnitudes of these differences require further investigation to determine clinical significance. Patient-applied forces were influenced by protrusion stiffness, but correction rate was not. Other factors may influence these variables, such as patient compliance. Treatment Study - Level IV. Copyright © 2018 Elsevier Inc. All rights reserved.

Mechanical Model of Dexterous Continuum Manipulators with Compliant Joints and Tendon/External Force Interactions

PubMed Central

Murphy, Ryan J.; Liu, Hao; Iordachita, Iulian I.; Armand, Mehran

2017-01-01

Dexterous continuum manipulators (DCMs) have been widely adopted for minimally- and less-invasive surgery. During the operation, these DCMs interact with surrounding anatomy actively or passively. The interaction force will inevitably affect the tip position and shape of DCMs, leading to potentially inaccurate control near critical anatomy. In this paper, we demonstrated a 2D mechanical model for a tendon actuated, notched DCM with compliant joints. The model predicted deformation of the DCM accurately in the presence of tendon force, friction force, and external force. A partition approach was proposed to describe the DCM as a series of interconnected rigid and flexible links. Beam mechanics, taking into consideration tendon interaction and external force on the tip and the body, was applied to obtain the deformation of each flexible link of the DCM. The model results were compared with experiments for free bending as well as bending in the presence of external forces acting at either the tip or body of the DCM. The overall mean error of tip position between model predictions and all of the experimental results was 0.62±0.41mm. The results suggest that the proposed model can effectively predict the shape of the DCM. PMID:28989273

A new algorithm for modeling friction in dynamic mechanical systems

NASA Technical Reports Server (NTRS)

Hill, R. E.

1988-01-01

A method of modeling friction forces that impede the motion of parts of dynamic mechanical systems is described. Conventional methods in which the friction effect is assumed a constant force, or torque, in a direction opposite to the relative motion, are applicable only to those cases where applied forces are large in comparison to the friction, and where there is little interest in system behavior close to the times of transitions through zero velocity. An algorithm is described that provides accurate determination of friction forces over a wide range of applied force and velocity conditions. The method avoids the simulation errors resulting from a finite integration interval used in connection with a conventional friction model, as is the case in many digital computer-based simulations. The algorithm incorporates a predictive calculation based on initial conditions of motion, externally applied forces, inertia, and integration step size. The predictive calculation in connection with an external integration process provides an accurate determination of both static and Coulomb friction forces and resulting motions in dynamic simulations. Accuracy of the results is improved over that obtained with conventional methods and a relatively large integration step size is permitted. A function block for incorporation in a specific simulation program is described. The general form of the algorithm facilitates implementation with various programming languages such as FORTRAN or C, as well as with other simulation programs.

Quantization and instability of the damped harmonic oscillator subject to a time-dependent force

NASA Astrophysics Data System (ADS)

Majima, H.; Suzuki, A.

2011-12-01

We consider the one-dimensional motion of a particle immersed in a potential field U(x) under the influence of a frictional (dissipative) force linear in velocity ( -γẋ) and a time-dependent external force ( K(t)). The dissipative system subject to these forces is discussed by introducing the extended Bateman's system, which is described by the Lagrangian: ℒ=mẋẏ-U(x+{1}/{2}y)+U(x-{1}/{2}y)+{γ}/{2}(xẏ-yẋ)-xK(t)+yK(t), which leads to the familiar classical equations of motion for the dissipative (open) system. The equation for a variable y is the time-reversed of the x motion. We discuss the extended Bateman dual Lagrangian and Hamiltonian by setting U(x±y/2)={1}/{2}k( specifically for a dual extended damped-amplified harmonic oscillator subject to the time-dependent external force. We show the method of quantizing such dissipative systems, namely the canonical quantization of the extended Bateman's Hamiltonian ℋ. The Heisenberg equations of motion utilizing the quantized Hamiltonian ℋ̂ surely lead to the equations of motion for the dissipative dynamical quantum systems, which are the quantum analog of the corresponding classical systems. To discuss the stability of the quantum dissipative system due to the influence of an external force K(t) and the dissipative force, we derived a formula for transition amplitudes of the dissipative system with the help of the perturbation analysis. The formula is specifically applied for a damped-amplified harmonic oscillator subject to the impulsive force. This formula is used to study the influence of dissipation such as the instability due to the dissipative force and/or the applied impulsive force.

Adaptation of multijoint coordination during standing balance in healthy young and healthy old individuals

PubMed Central

Pasma, J. H.; Schouten, A. C.; Aarts, R. G. K. M.; Meskers, C. G. M.; Maier, A. B.; van der Kooij, H.

2015-01-01

Standing balance requires multijoint coordination between the ankles and hips. We investigated how humans adapt their multijoint coordination to adjust to various conditions and whether the adaptation differed between healthy young participants and healthy elderly. Balance was disturbed by push/pull rods, applying two continuous and independent force disturbances at the level of the hip and between the shoulder blades. In addition, external force fields were applied, represented by an external stiffness at the hip, either stabilizing or destabilizing the participants' balance. Multivariate closed-loop system-identification techniques were used to describe the neuromuscular control mechanisms by quantifying the corrective joint torques as a response to body sway, represented by frequency response functions (FRFs). Model fits on the FRFs resulted in an estimation of time delays, intrinsic stiffness, reflexive stiffness, and reflexive damping of both the ankle and hip joint. The elderly generated similar corrective joint torques but had reduced body sway compared with the young participants, corresponding to the increased FRF magnitude with age. When a stabilizing or destabilizing external force field was applied at the hip, both young and elderly participants adapted their multijoint coordination by lowering or respectively increasing their neuromuscular control actions around the ankles, expressed in a change of FRF magnitude. However, the elderly adapted less compared with the young participants. Model fits on the FRFs showed that elderly had higher intrinsic and reflexive stiffness of the ankle, together with higher time delays of the hip. Furthermore, the elderly adapted their reflexive stiffness around the ankle joint less compared with young participants. These results imply that elderly were stiffer and were less able to adapt to external force fields. PMID:26719084

Is optimal paddle force applied during paediatric external defibrillation?

PubMed

Bennetts, Sarah H; Deakin, Charles D; Petley, Graham W; Clewlow, Frank

2004-01-01

Optimal paddle force minimises transthoracic impedance; a factor associated with increased defibrillation success. Optimal force for the defibrillation of children < or =10 kg using paediatric paddles has previously been shown to be 2.9 kgf, and for children >10 kg using adult paddles is 5.1 kgf. We compared defibrillation paddle force applied during simulated paediatric defibrillation with these optimal values. 72 medical and nursing staff who would be expected to perform paediatric defibrillation were recruited from a University teaching hospital. Participants, blinded to the nature of the study, were asked to simulate defibrillation of an infant manikin (9 months of age) and a child manikin (6 years of age) using paediatric or adult paddles, respectively, according to guidelines. Paddle force (kgf) was measured at the time of simulated shock and compared with known optimal values. Median paddle force applied to the infant manikin was 2.8 kgf (max 9.6, min 0.6), with only 47% operators attaining optimal force. Median paddle force applied to the child manikin was 3.8 kgf (max 10.2, min 1.0), with only 24% of operators attaining optimal force. Defibrillation paddle force applied during paediatric defibrillation often falls below optimal values.

Highly sensitive protein detection by combination of atomic force microscopy fishing with charge generation and mass spectrometry analysis.

PubMed

Ivanov, Yuri D; Pleshakova, Tatyana; Malsagova, Krystina; Kozlov, Andrey; Kaysheva, Anna; Kopylov, Arthur; Izotov, Alexander; Andreeva, Elena; Kanashenko, Sergey; Usanov, Sergey; Archakov, Alexander

2014-10-01

An approach combining atomic force microscopy (AFM) fishing and mass spectrometry (MS) analysis to detect proteins at ultra-low concentrations is proposed. Fishing out protein molecules onto a highly oriented pyrolytic graphite surface coated with polytetrafluoroethylene film was carried out with and without application of an external electric field. After that they were visualized by AFM and identified by MS. It was found that injection of solution leads to charge generation in the solution, and an electric potential within the measuring cell is induced. It was demonstrated that without an external electric field in the rapid injection input of diluted protein solution the fishing is efficient, as opposed to slow fluid input. The high sensitivity of this method was demonstrated by detection of human serum albumin and human cytochrome b5 in 10(-17) -10(-18) m water solutions. It was shown that an external negative voltage applied to highly oriented pyrolytic graphite hinders the protein fishing. The efficiency of fishing with an external positive voltage was similar to that obtained without applying any voltage. © 2014 FEBS.

Device for use in loading tension members. [characterized by elongated elastic body

NASA Technical Reports Server (NTRS)

Appleberry, W. T. (Inventor)

1975-01-01

The indicator is characterized by an elongated elastic body having extended from the opposite ends of threaded shanks adapted to selected tension members. A pair of external shoulders, one of which is axially displaceable relative to the other, and a rigid tubular sleeve interposed between said shoulders are included. Tension is applied to the elastic body for imparting strain. The movable shoulder can be advanced into abutting engagement with the sleeve, whereby the sleeve is placed in compression once the tensile forces are removed from the shanks. A reapplication of tensile forces equal to the initially applied tensile forces removes the sleeve from compression, whereby the sleeve is freed for rotation for thus indicating the magnitude of the applied tensile forces.

Rotor vibration caused by external excitation and rub

NASA Technical Reports Server (NTRS)

Matsushita, O.; Takagi, M.; Kikuchi, K.; Kaga, M.

1982-01-01

For turbomachinery with low natural frequencies, considerations have been recently required for rotor vibrations caused by external forces except unbalance one, such as foundation motion, seismic wave, rub and so forth. Such a forced vibration is investigated analytically and experimentally in the present paper. Vibrations in a rotor-bearing system under a harmonic excitation are analyzed by the modal technique in the case of a linear system including gyroscopic effect. For a nonlinear system a new and powerful quasi-modal technique is developed and applied to the vibration caused by rub.

Studying Climate Response to Forcing by the Nonlinear Dynamical Mode Decomposition

NASA Astrophysics Data System (ADS)

Mukhin, Dmitry; Gavrilov, Andrey; Loskutov, Evgeny; Feigin, Alexander

2017-04-01

An analysis of global climate response to external forcing, both anthropogenic (mainly, CO2 and aerosol) and natural (solar and volcanic), is needed for adequate predictions of global climate change. Being complex dynamical system, the climate reacts to external perturbations exciting feedbacks (both positive and negative) making the response non-trivial and poorly predictable. Thus an extraction of internal modes of climate system, investigation of their interaction with external forcings and further modeling and forecast of their dynamics, are all the problems providing the success of climate modeling. In the report the new method for principal mode extraction from climate data is presented. The method is based on the Nonlinear Dynamical Mode (NDM) expansion [1,2], but takes into account a number of external forcings applied to the system. Each NDM is represented by hidden time series governing the observed variability, which, together with external forcing time series, are mapped onto data space. While forcing time series are considered to be known, the hidden unknown signals underlying the internal climate dynamics are extracted from observed data by the suggested method. In particular, it gives us an opportunity to study the evolution of principal system's mode structure in changing external conditions and separate the internal climate variability from trends forced by external perturbations. Furthermore, the modes so obtained can be extrapolated beyond the observational time series, and long-term prognosis of modes' structure including characteristics of interconnections and responses to external perturbations, can be carried out. In this work the method is used for reconstructing and studying the principal modes of climate variability on inter-annual and decadal time scales accounting the external forcings such as anthropogenic emissions, variations of the solar activity and volcanic activity. The structure of the obtained modes as well as their response to external factors, e.g. forecast their change in 21 century under different CO2 emission scenarios, are discussed. [1] Mukhin, D., Gavrilov, A., Feigin, A., Loskutov, E., & Kurths, J. (2015). Principal nonlinear dynamical modes of climate variability. Scientific Reports, 5, 15510. http://doi.org/10.1038/srep15510 [2] Gavrilov, A., Mukhin, D., Loskutov, E., Volodin, E., Feigin, A., & Kurths, J. (2016). Method for reconstructing nonlinear modes with adaptive structure from multidimensional data. Chaos: An Interdisciplinary Journal of Nonlinear Science, 26(12), 123101. http://doi.org/10.1063/1.4968852

The Role of the External Linkage Agent in College and University Action Research.

ERIC Educational Resources Information Center

Lindquist, Jack

The Strategies for Change and Knowledge Project is a concrete attempt to apply the Lindage model to eight colleges and universities. It is completing its third year of on-campus task force action to stimulate academic reform, of linking agent, survey feedback, workshop and consultant aid to those problemsolving efforts, and of external research…

Scattering of accelerated wave packets

NASA Astrophysics Data System (ADS)

Longhi, S.; Horsley, S. A. R.; Della Valle, G.

2018-03-01

Wave-packet scattering from a stationary potential is significantly modified when the wave packet is subject to an external time-dependent force during the interaction. In the semiclassical limit, wave-packet motion is simply described by Newtonian equations, and the external force can, for example, cancel the potential force, making a potential barrier transparent. Here we consider wave-packet scattering from reflectionless potentials, where in general the potential becomes reflective when probed by an accelerated wave packet. In the particular case of the recently introduced class of complex Kramers-Kronig potentials we show that a broad class of time-dependent forces can be applied without inducing any scattering, while there is a breakdown of the reflectionless property when there is a broadband distribution of initial particle momentum, involving both positive and negative components.

Mechanical regulation of T-cell functions

PubMed Central

Chen, Wei; Zhu, Cheng

2013-01-01

Summary T cells are key players of the mammalian adaptive immune system. They experience different mechanical microenvironments during their life cycles, from the thymus, secondary lymph organs, and peripheral tissues that are free of externally applied force but display variable substrate rigidities, to the blood and lymphatic circulation systems where complicated hydrodynamic forces are present. Regardless of whether T cells are subject to external forces or generate their own internal forces, they response and adapt to different biomechanical cues to modulate their adhesion, migration, trafficking, and triggering of immune functions through mechanical regulation of various molecules that bear force. These include adhesive receptors, immunoreceptors, motor proteins, cytoskeletal proteins, and their associated molecules. Here we discuss the forces acting on various surface and cytoplasmic proteins of a T cell in different mechanical milieus. We review existing data on how force regulates protein conformational changes and interactions with counter molecules, including integrins, actin, and the T-cell receptor, and how each relates to T-cell functions. PMID:24117820

H Infinity Control of Magnetic Bearings to Ensure Both System and External Periodic Disturbance Robustness

NASA Technical Reports Server (NTRS)

Jiang, Yuhong; Zmood, R. B.

1996-01-01

Both self-excited and forced disturbances often lead to severe rotor vibrations in a magnetic bearing systems with long slender shafts. This problem has been studied using the H-infinity method, and stability with good robustness can be achieved for the linearized model of a magnetic bearing when small transient disturbances are applied. In this paper, the H-infinity control method for self-excited and forced disturbances is first reviewed. It is then applied to the control of a magnetic bearing rotor system. In modelling the system, the shaft is first discretized into 18 finite elements and then three levels of condensation are applied. This leads to a system with three masses and three compliant elements which can be described by six state variable coordinates. Simulation of the resultant system design has been performed at speeds up to 10,000 rpm. Disturbances in terms of different initial displacements, initial impulses, and external periodic inputs have been imposed. The simulation results show that good stability can be achieved under these different transient disturbances using the proposed controller while at the same time reducing the sensitivity to external periodic disturbances.

Homodyne detection of short-range Doppler radar using a forced oscillator model

NASA Astrophysics Data System (ADS)

Kittipute, Kunanon; Saratayon, Peerayudh; Srisook, Suthasin; Wardkein, Paramote

2017-03-01

This article presents the homodyne detection in a self-oscillation system, which represented by a short-range radar (SRR) circuit, that is analysed using a multi-time forced oscillator (MTFO) model. The MTFO model is based on a forced oscillation perspective with the signal and system theory, a second-order differential equation, and the multiple time variable technique. This model can also apply to analyse the homodyne phenomenon in a difference kind of the oscillation system under same method such as the self-oscillation system, and the natural oscillation system with external forced. In a free oscillation system, which forced by the external source is represented by a pendulum with an oscillating support experiment, and a modified Colpitts oscillator circuit in the UHF band with input as a Doppler signal is a representative of self-oscillation system. The MTFO model is verified with the experimental result, which well in line with the theoretical analysis.

Tibiofemoral contact forces during walking, running and sidestepping.

PubMed

Saxby, David J; Modenese, Luca; Bryant, Adam L; Gerus, Pauline; Killen, Bryce; Fortin, Karine; Wrigley, Tim V; Bennell, Kim L; Cicuttini, Flavia M; Lloyd, David G

2016-09-01

We explored the tibiofemoral contact forces and the relative contributions of muscles and external loads to those contact forces during various gait tasks. Second, we assessed the relationships between external gait measures and contact forces. A calibrated electromyography-driven neuromusculoskeletal model estimated the tibiofemoral contact forces during walking (1.44±0.22ms(-1)), running (4.38±0.42ms(-1)) and sidestepping (3.58±0.50ms(-1)) in healthy adults (n=60, 27.3±5.4years, 1.75±0.11m, and 69.8±14.0kg). Contact forces increased from walking (∼1-2.8 BW) to running (∼3-8 BW), sidestepping had largest maximum total (8.47±1.57 BW) and lateral contact forces (4.3±1.05 BW), while running had largest maximum medial contact forces (5.1±0.95 BW). Relative muscle contributions increased across gait tasks (up to 80-90% of medial contact forces), and peaked during running for lateral contact forces (∼90%). Knee adduction moment (KAM) had weak relationships with tibiofemoral contact forces (all R(2)<0.36) and the relationships were gait task-specific. Step-wise regression of multiple external gait measures strengthened relationships (0.20

Forced transport of self-propelled particles in a two-dimensional separate channel.

PubMed

Wu, Jian-chun; Ai, Bao-quan

2016-04-01

Transport of self-propelled particles in a two-dimensional (2D) separate channel is investigated in the presence of the combined forces. By applying an ac force, the particles will be trapped by the separate walls. A dc force produces the asymmetry of the system and induces the longitudinal directed transport. Due to the competition between self-propulsion and the combined external forces, the transport is sensitive to the self-propelled speed and the particle radius, thus one can separate the particles based on these properties.

Mechanical stability of the subtalar joint after lateral ligament sectioning and ankle brace application: a biomechanical experimental study.

PubMed

Kamiya, Tomoaki; Kura, Hideji; Suzuki, Daisuke; Uchiyama, Eiichi; Fujimiya, Mineko; Yamashita, Toshihiko

2009-12-01

The roles of each ligament supporting the subtalar joint have not been clarified despite several biomechanical studies. The effects of ankle braces on subtalar instability have not been shown. The ankle brace has a partial effect on restricting excessive motion of the subtalar joint. Controlled laboratory study. Ten normal fresh-frozen cadaveric specimens were used. The angular motions of the talus were measured via a magnetic tracking system. The specimens were tested while inversion and eversion forces, as well as internal and external rotation torques, were applied. The calcaneofibular ligament, cervical ligament, and interosseous talocalcaneal ligament were sectioned sequentially, and the roles of each ligament, as well as the stabilizing effects of the ankle brace, were examined. Complete sectioning of the ligaments increased the angle between the talus and calcaneus in the frontal plane to 51.7 degrees + or - 11.8 degrees compared with 35.7 degrees + or - 6.0 degrees in the intact state when inversion force was applied. There was a statistically significant difference in the angles between complete sectioning of the ligaments and after application of the brace (34.1 degrees + or - 7.3 degrees ) when inversion force was applied. On the other hand, significant differences in subtalar rotation were not found between complete sectioning of the ligaments and application of the brace when internal and external rotational torques were applied. The ankle brace limited inversion of the subtalar joint, but it did not restrict motion after application of internal or external rotational torques. In cases of severe ankle sprains involving the calcaneofibular ligament, cervical ligament, and interosseous talocalcaneal ligament injuries, application of an ankle brace might be less effective in limiting internal-external rotational instabilities than in cases of inversion instabilities in the subtalar joint. An improvement in the design of the brace is needed to restore better rotational stability in the subtalar joint.

The Effect of Insertion Technique on Temperatures for Standard and Self-Drilling External Fixation Pins.

PubMed

Manoogian, Sarah; Lee, Adam K; Widmaier, James C

2017-08-01

No studies have assessed the effects of parameters associated with insertion temperature in modern self-drilling external fixation pins. The current study assessed how varying the presence of irrigation, insertion speed, and force impacted the insertion temperatures of 2 types of standard and self-drilling external fixation half pins. Seventy tests were conducted with 10 trials for 4 conditions on self-drilling pins, and 3 conditions for standard pins. Each test used a thermocouple inside the pin to measure temperature rise during insertion. Adding irrigation to the standard pin insertion significantly lowered the maximum temperature (P <0.001). Lowering the applied force for the standard pin did not have a significant change in temperature rise. Applying irrigation during the self-drilling pin tests dropped average rise in temperature from 151.3 ± 21.6°C to 124.1 ± 15.3°C (P = 0.005). When the self-drilling pin insertion was decreased considerably from 360 to 60 rpm, the temperature decreased significantly from 151.3 ± 21.6°C to 109.6 ± 14.0°C (P <0.001). When the force applied increased significantly, the corresponding self-drilling pin temperature increase was not significant. The standard pin had lower peak temperatures than the self-drilling pin for all conditions. Moreover, slowing down the insertion speed and adding irrigation helped mitigate the temperature increase of both pin types during insertion.

Application of largest Lyapunov exponent analysis on the studies of dynamics under external forces

NASA Astrophysics Data System (ADS)

Odavić, Jovan; Mali, Petar; Tekić, Jasmina; Pantić, Milan; Pavkov-Hrvojević, Milica

2017-06-01

Dynamics of driven dissipative Frenkel-Kontorova model is examined by using largest Lyapunov exponent computational technique. Obtained results show that besides the usual way where behavior of the system in the presence of external forces is studied by analyzing its dynamical response function, the largest Lyapunov exponent analysis can represent a very convenient tool to examine system dynamics. In the dc driven systems, the critical depinning force for particular structure could be estimated by computing the largest Lyapunov exponent. In the dc+ac driven systems, if the substrate potential is the standard sinusoidal one, calculation of the largest Lyapunov exponent offers a more sensitive way to detect the presence of Shapiro steps. When the amplitude of the ac force is varied the behavior of the largest Lyapunov exponent in the pinned regime completely reflects the behavior of Shapiro steps and the critical depinning force, in particular, it represents the mirror image of the amplitude dependence of critical depinning force. This points out an advantage of this technique since by calculating the largest Lyapunov exponent in the pinned regime we can get an insight into the dynamics of the system when driving forces are applied. Additionally, the system is shown to be not chaotic even in the case of incommensurate structures and large amplitudes of external force, which is a consequence of overdampness of the model and the Middleton's no passing rule.

The use of electromagnetic body forces to enhance the quality of laser welds

NASA Astrophysics Data System (ADS)

Ambrosy, Guenter; Berger, P.; Huegel, H.; Lindenau, D.

2003-11-01

The use of electromagnetic body forces in laser beam welding of aluminum alloys is a new method to shape the geometry and to enhance the quality of the weld seams. In this new approach, electromagnetic volume forces are utilized by applying magnetic fields and electric currents of various origins. Acting in the liquid metal, they directly affect the flow field and can lead to favourable conditions for the melt dynamics and energy coupling. Numerous welds with full and partial penetration using both CO2 and Nd:YAG lasers demonstrate that this method directly influences the seam geometry and top-bead topography as well as the penetration depth and the evolution of pores and cracks. In the case of full penetration, it is also possible to lift or to lower the weld pool. The method, therefore, can be used to shape the geometry and to enhance the quality of the weld seam. Depending on the orientation of an external magnetic field, significant impacts are achieved in CO2 welding, even without an external current: the shape of the cross-sectional area can be increased of up to 50% and also the seam width is changed. Whereas for such conditions with Nd:YAG lasers no significant effect could be observed, it turned out that, when an external electric current is applied, similar effects are present with both wavelengths. In further investigations, the effect of electromagnetic body forces resulting from the interaction of an external current and its self-induced magnetic field was studied. Hereby, the current was fed into the workpiece via a tungsten electrode or a filler wire. The resulting phenomena are the same independent from wavelength and means of current feed.

Effects of laparoscopic instrument and finger on force perception: a first step towards laparoscopic force-skills training.

PubMed

Raghu Prasad, M S; Manivannan, M; Chandramohan, S M

2015-07-01

In laparoscopic surgery, no external feedback on the magnitude of the force exerted is available. Hence, surgeons and residents tend to exert excessive force, which leads to tissue trauma. Ability of surgeons and residents to perceive their own force output without external feedback is a critical factor in laparoscopic force-skills training. Additionally, existing methods of laparoscopic training do not effectively train residents and novices on force-skills. Hence, there is growing need for the development of force-based training curriculum. As a first step towards force-based laparoscopic skills training, this study analysed force perception difference between laparoscopic instrument and finger in contralateral bimanual passive probing task. The study compared the isometric force matching performance of novices, residents and surgeons with finger and laparoscopic instrument. Contralateral force matching paradigm was employed to analyse the force perception capability in terms of relative (accuracy), and constant errors in force matching. Force perception of experts was found to be better than novices and residents. Interestingly, laparoscopic instrument was more accurate in discriminating the forces than finger. The dominant hand attempted to match the forces accurately, whereas non-dominant hand (NH) overestimated the forces. Further, the NH of experts was found to be most accurate. Furthermore, excessive forces were applied at lower force levels and at very high force levels. Due to misperception of force, novices and residents applied excessive forces. However, experts had good control over force with both dominant and NHs. These findings suggest that force-based training curricula should not only have proprioception tasks, but should also include bimanual force-skills training exercises in order to improve force perception ability and hand skills of novices and residents. The results can be used as a performance metric in both box and virtual reality based force-skills training.

DNA under Force: Mechanics, Electrostatics, and Hydration.

PubMed

Li, Jingqiang; Wijeratne, Sithara S; Qiu, Xiangyun; Kiang, Ching-Hwa

2015-02-25

Quantifying the basic intra- and inter-molecular forces of DNA has helped us to better understand and further predict the behavior of DNA. Single molecule technique elucidates the mechanics of DNA under applied external forces, sometimes under extreme forces. On the other hand, ensemble studies of DNA molecular force allow us to extend our understanding of DNA molecules under other forces such as electrostatic and hydration forces. Using a variety of techniques, we can have a comprehensive understanding of DNA molecular forces, which is crucial in unraveling the complex DNA functions in living cells as well as in designing a system that utilizes the unique properties of DNA in nanotechnology.

Study of adhesion of vertically aligned carbon nanotubes to a substrate by atomic-force microscopy

NASA Astrophysics Data System (ADS)

Ageev, O. A.; Blinov, Yu. F.; Il'ina, M. V.; Il'in, O. I.; Smirnov, V. A.; Tsukanova, O. G.

2016-02-01

The adhesion to a substrate of vertically aligned carbon nanotubes (VA CNT) produced by plasmaenhanced chemical vapor deposition has been experimentally studied by atomic-force microscopy in the current spectroscopy mode. The longitudinal deformation of VA CNT by applying an external electric field has been simulated. Based on the results, a technique of determining VA CNT adhesion to a substrate has been developed that is used to measure the adhesion strength of connecting VA CNT to a substrate. The adhesion to a substrate of VA CNT 70-120 nm in diameter varies from 0.55 to 1.19 mJ/m2, and the adhesion force from 92.5 to 226.1 nN. When applying a mechanical load, the adhesion strength of the connecting VA CNT to a substrate is 714.1 ± 138.4 MPa, and the corresponding detachment force increases from 1.93 to 10.33 μN with an increase in the VA CNT diameter. As an external electric field is applied, the adhesion strength is almost doubled and is 1.43 ± 0.29 GPa, and the corresponding detachment force is changed from 3.83 to 20.02 μN. The results can be used in the design of technological processes of formation of emission structures, VA CNT-based elements for vacuum microelectronics and micro- and nanosystem engineering, and also the methods of probe nanodiagnostics of VA CNT.

Controlling Force and Depth in Friction Stir Welding

NASA Technical Reports Server (NTRS)

Adams, Glynn; Loftus, Zachary; McCormac, Nathan; Venable, Richard

2005-01-01

Feedback control of the penetration force applied to a pin tool in friction stir welding has been found to be a robust and reliable means for controlling the depth of penetration of the tool. This discovery has made it possible to simplify depth control and to weld with greater repeatability, even on workpieces with long weld joints. Prior to this discovery, depths of penetration in friction stir welding were controlled by hard-tooled roller assemblies or by depth actuators controlled by feedback from such external sensors as linear variable-differential transformers or laser-based devices. These means of control are limited: A hard-tooled roller assembly confines a pin tool to a preset depth that cannot be changed easily during the welding process. A measurement by an external sensor is only an indirect indicative of the depth of penetration, and computations to correlate such a measurement with a depth of penetration are vulnerable to error. The present force-feedback approach exploits the proportionality between the depth and the force of penetration Unlike a depth measurement taken by an external sensor, a force measurement can be direct because it can be taken by a sensor coupled directly to the pin tool. The reading can be processed through a modern electronic servo control system to control an actuator to keep the applied penetration force at the desired level. In comparison with the older depth-control methods described above, this method offers greater sensitivity to plasticizing of the workpiece metal and is less sensitive to process noise, resulting in a more consistent process. In an experiment, a tapered panel was friction stir welded while controlling the force of penetration according to this method. The figure is a plot of measurements taken during the experiment, showing that force was controlled with a variation of 200 lb (890 N), resulting in control of the depth of penetration with a variation of 0.004 in. (0.1 mm).

A metabolic basis for impaired muscle force production and neuromuscular compensation during sprint cycling.

PubMed

Bundle, Matthew W; Ernst, Carrie L; Bellizzi, Matthew J; Wright, Seth; Weyand, Peter G

2006-11-01

For both different individuals and modes of locomotion, the external forces determining all-out sprinting performances fall predictably with effort duration from the burst maximums attained for 3 s to those that can be supported aerobically as trial durations extend to roughly 300 s. The common time course of this relationship suggests a metabolic basis for the decrements in the force applied to the environment. However, the mechanical and neuromuscular responses to impaired force production (i.e., muscle fatigue) are generally considered in relation to fractions of the maximum force available, or the maximum voluntary contraction (MVC). We hypothesized that these duration-dependent decrements in external force application result from a reliance on anaerobic metabolism for force production rather than the absolute force produced. We tested this idea by examining neuromuscular activity during two modes of sprint cycling with similar external force requirements but differing aerobic and anaerobic contributions to force production: one- and two-legged cycling. In agreement with previous studies, we found greater peak per leg aerobic metabolic rates [59% (+/-6 SD)] and pedal forces at VO2 peak [30% (+/-9)] during one- vs. two-legged cycling. We also determined downstroke pedal forces and neuromuscular activity by surface electromyography during 15 to 19 all-out constant load sprints lasting from 12 to 400 s for both modes of cycling. In support of our hypothesis, we found that the greater reliance on anaerobic metabolism for force production induced compensatory muscle recruitment at lower pedal forces during two- vs. one-legged sprint cycling. We conclude that impaired muscle force production and compensatory neuromuscular activity during sprinting are triggered by a reliance on anaerobic metabolism for force production.

Driving morphological changes in magnetic nanoparticle structures through the application of acoustic waves and magnetic fields

NASA Astrophysics Data System (ADS)

Huang, Ann; Miansari, Morteza; Friend, James

The growing interest in acoustic manipulation of particles in micro to nanofluidics using surface acoustic waves (SAW), together with the many applications of magnetic nanoparticles-whether individual or in arrays-underpins our discovery of how these forces can be used to rapidly, easily, and irreversibly form 1D chains and 2D films. These films and chains are currently difficult to produce yet offer many advantages over individual nanoparticles in suspension. Making use of the scale of the structures formed, 10-9 to 10-5 m, and by taking a balance of the relevant external and interparticle forces, the underlying mechanisms responsible for the phenomena become apparent. For 1D chains, the magnetic field alone is sufficient, though applying an acoustic field drives a topology change from loosely connected chains to loops of 10 -100 particles. Adding the acoustic field drives a transition from these looped structures to dense 2D arrays via interparticle Bjerknes forces. Inter-particle drainage of the surrounding fluid leaves these structures intact after removal of the externally applied forces. Clear morphology transitions are present and depend on the relative amplitude of the incident Brownian, Bjerknes, and magnetic forces. UCSD: Frontiers of Innovation Scholars Program (U-1024).

Can a double stranded DNA be unzipped by pulling a single strand?: phases of adsorbed DNA.

PubMed

Kapri, Rajeev

2009-04-14

We study the unzipping of a double stranded DNA (dsDNA) by applying an external force on a single strand while leaving the other strand free. We find that the dsDNA can be unzipped to two single strands if the external force exceeds a critical value. We obtain the phase diagram, which is found to be different from the phase diagram of unzipping by pulling both the strands in opposite directions. In the presence of an attractive surface near DNA, the phase diagram gets modified drastically and shows richer surprises including a critical end point and a triple point.

Characterization of structural and electrical properties of ZnO tetrapods

NASA Astrophysics Data System (ADS)

Gu, Yu-Dong; Mai, Wen-Jie; Jiang, Peng

2011-12-01

ZnO tetrapods were synthesized by a typical thermal vapor-solid deposition method in a horizontal tube furnace. Structural characterization was carried out by transmission electron microscopy (TEM) and select-area electron diffraction (SAED), which shows the presence of zinc blende nucleus in the center of tetrapods while the four branches taking hexagonal wurtzite structure. The electrical transport property of ZnO tetrapods was investigated through an in-situ nanoprobe system. The three branches of a tetrapod serve as source, drain, and "gate", respectively; while the fourth branch pointing upward works as the force trigger by vertically applying external force downward. The conductivity of each branch of ZnO-tetrapods increases 3-4 times under pressure. In such situation, the electrical current through the branches of ZnO tetrapods can be tuned by external force, and therefore a simple force sensor based on ZnO tetrapods has been demonstrated for the first time.

Error analysis and assessment of unsteady forces acting on a flapping wing micro air vehicle: free flight versus wind-tunnel experimental methods.

PubMed

Caetano, J V; Percin, M; van Oudheusden, B W; Remes, B; de Wagter, C; de Croon, G C H E; de Visser, C C

2015-08-20

An accurate knowledge of the unsteady aerodynamic forces acting on a bio-inspired, flapping-wing micro air vehicle (FWMAV) is crucial in the design development and optimization cycle. Two different types of experimental approaches are often used: determination of forces from position data obtained from external optical tracking during free flight, or direct measurements of forces by attaching the FWMAV to a force transducer in a wind-tunnel. This study compares the quality of the forces obtained from both methods as applied to a 17.4 gram FWMAV capable of controlled flight. A comprehensive analysis of various error sources is performed. The effects of different factors, e.g., measurement errors, error propagation, numerical differentiation, filtering frequency selection, and structural eigenmode interference, are assessed. For the forces obtained from free flight experiments it is shown that a data acquisition frequency below 200 Hz and an accuracy in the position measurements lower than ± 0.2 mm may considerably hinder determination of the unsteady forces. In general, the force component parallel to the fuselage determined by the two methods compares well for identical flight conditions; however, a significant difference was observed for the forces along the stroke plane of the wings. This was found to originate from the restrictions applied by the clamp to the dynamic oscillations observed in free flight and from the structural resonance of the clamped FWMAV structure, which generates loads that cannot be distinguished from the external forces. Furthermore, the clamping position was found to have a pronounced influence on the eigenmodes of the structure, and this effect should be taken into account for accurate force measurements.

Power, muscular work, and external forces in cycling.

PubMed

de Groot, G; Welbergen, E; Clijsen, L; Clarijs, J; Cabri, J; Antonis, J

1994-01-01

Cycling performance is affected by the interaction of a number of variables, including environment, mechanical, and human factors. Engineers have focused on the development of more efficient bicycles. Kinesiologists have examined cycling performance from a human perspective. This paper summarizes only certain aspects of human ergonomics of cycling, especially those which are important for the recent current research in our departments. Power is a key to performance of physical work. During locomotion an imaginary flow of energy takes place from the metabolism to the environment, with some efficiency. The 'useful' mechanical muscle power output might be used to perform movements and to do work against the environment. The external power is defined as the sum of joint powers, each calculated as the product of the joint (net) moment and angular velocity. This definition of external power is closely related to the mean external power as applied to exercise physiology: the sum of joint powers reflects all mechanical power which in principle can be used to fulfil a certain task. In this paper, the flow of energy for cycling is traced quantitatively as far as possible. Studies on the total lower limb can give insight into the contribution of individual muscles to external power. The muscle velocity (positive or negative) is obtained from the positions and orientations of body segments and a bar linkage model of the lower limb. The muscle activity can be measured by electromyography. In this way, positive and negative work regions in individual muscles are identified. Synergy between active agonistic/antagonistic muscle groups occurs in order to deliver external power. Maximum power is influenced by body position, geometry of the bicycle and pedalling rate. This has to be interpreted in terms of the length-tension and force-velocity-power relationships of the involved muscles. Flat road and uphill cycling at different saddle-tube angles is simulated on an ergometer. The measured pedal forces (magnitude and direction) are only dependent on the intersegmental orientation of saddle tube, crank position, upper and lower leg, and foot. The changed direction of the gravitational force with respect to the saddle-tube does not interfere with the co-ordinated force production pattern. During locomotory cycling at constant speed the external power is mainly used to overcome the aerodynamic friction force. This force and the rolling resistance are determined by coasting down experiments, yielding the external power.(ABSTRACT TRUNCATED AT 400 WORDS)

Responses to applied forces and the Jarzynski equality in classical oscillator systems coupled to finite baths: an exactly solvable nondissipative nonergodic model.

PubMed

Hasegawa, Hideo

2011-07-01

Responses of small open oscillator systems to applied external forces have been studied with the use of an exactly solvable classical Caldeira-Leggett model in which a harmonic oscillator (system) is coupled to finite N-body oscillators (bath) with an identical frequency (ω(n) = ω(o) for n = 1 to N). We have derived exact expressions for positions, momenta, and energy of the system in nonequilibrium states and for work performed by applied forces. A detailed study has been made on an analytical method for canonical averages of physical quantities over the initial equilibrium state, which is much superior to numerical averages commonly adopted in simulations of small systems. The calculated energy of the system which is strongly coupled to a finite bath is fluctuating but nondissipative. It has been shown that the Jarzynski equality is valid in nondissipative nonergodic open oscillator systems regardless of the rate of applied ramp force.

Combination of Universal Mechanical Testing Machine with Atomic Force Microscope for Materials Research

PubMed Central

Zhong, Jian; He, Dannong

2015-01-01

Surface deformation and fracture processes of materials under external force are important for understanding and developing materials. Here, a combined horizontal universal mechanical testing machine (HUMTM)-atomic force microscope (AFM) system is developed by modifying UMTM to combine with AFM and designing a height-adjustable stabilizing apparatus. Then the combined HUMTM-AFM system is evaluated. Finally, as initial demonstrations, it is applied to analyze the relationship among macroscopic mechanical properties, surface nanomorphological changes under external force, and fracture processes of two kinds of representative large scale thin film materials: polymer material with high strain rate (Parafilm) and metal material with low strain rate (aluminum foil). All the results demonstrate the combined HUMTM-AFM system overcomes several disadvantages of current AFM-combined tensile/compression devices including small load force, incapability for large scale specimens, disability for materials with high strain rate, and etc. Therefore, the combined HUMTM-AFM system is a promising tool for materials research in the future. PMID:26265357

Combination of Universal Mechanical Testing Machine with Atomic Force Microscope for Materials Research.

PubMed

Zhong, Jian; He, Dannong

2015-08-12

Surface deformation and fracture processes of materials under external force are important for understanding and developing materials. Here, a combined horizontal universal mechanical testing machine (HUMTM)-atomic force microscope (AFM) system is developed by modifying UMTM to combine with AFM and designing a height-adjustable stabilizing apparatus. Then the combined HUMTM-AFM system is evaluated. Finally, as initial demonstrations, it is applied to analyze the relationship among macroscopic mechanical properties, surface nanomorphological changes under external force, and fracture processes of two kinds of representative large scale thin film materials: polymer material with high strain rate (Parafilm) and metal material with low strain rate (aluminum foil). All the results demonstrate the combined HUMTM-AFM system overcomes several disadvantages of current AFM-combined tensile/compression devices including small load force, incapability for large scale specimens, disability for materials with high strain rate, and etc. Therefore, the combined HUMTM-AFM system is a promising tool for materials research in the future.

Homodyne detection of short-range Doppler radar using a forced oscillator model

PubMed Central

Kittipute, Kunanon; Saratayon, Peerayudh; Srisook, Suthasin; Wardkein, Paramote

2017-01-01

This article presents the homodyne detection in a self-oscillation system, which represented by a short-range radar (SRR) circuit, that is analysed using a multi-time forced oscillator (MTFO) model. The MTFO model is based on a forced oscillation perspective with the signal and system theory, a second-order differential equation, and the multiple time variable technique. This model can also apply to analyse the homodyne phenomenon in a difference kind of the oscillation system under same method such as the self-oscillation system, and the natural oscillation system with external forced. In a free oscillation system, which forced by the external source is represented by a pendulum with an oscillating support experiment, and a modified Colpitts oscillator circuit in the UHF band with input as a Doppler signal is a representative of self-oscillation system. The MTFO model is verified with the experimental result, which well in line with the theoretical analysis. PMID:28252000

Short-Term Intraocular Pressure Rise during Locally Induced Force by Ophthalmologic Surgery Applications.

PubMed

Koelbl, Philipp Simon; Werner, Jens Ulrich; Enders, Christian; Lingenfelder, Christian; Koch, Frank H J; Hessling, Martin

2018-05-31

Surgical or diagnostic procedures are often accompanied by a short-term increase in intraocular pressure (IOP). A short-term increase in IOP can occur during refractive procedures, vitreoretinal surgery, transillumination, photocoagulation, or cryocoagulation. A porcine eye model was chosen (n = 89) to compile comparable study data and to de termine correlations between the force induced and the resulting intraocular pressure while excluding the effect of surgeons. The IOP was measured in the anterior chamber. IOP changes were induced by applying an external force and measured when using a cannula, trocar, and cryocoagulation (n = 32), and correlations between force and resulting IOP were assessed (n = 57). A correlation was noted between the force induced and the IOP increase, which showed a linear dependency. The insertion of a 29-G cannula caused a mean ΔIOP value of 49.1 ± 2.9 mm Hg and an external force of 0.76 N, and that of a 23-G trocar 344.4 ± 5.9 mm Hg and 6.09 N, respectively. The rise in IOP during a simulated cryocoagulation reached values between 57.3 ± 14.8 mm Hg (cryoprobe tip diameter: 0.9 mm) and 130.3 ± 2.9 mm Hg (cryoprobe tip diameter: 7.0 mm). The values of the forces applied can be converted into the resulting IOP based on the specific action. Surgical or diagnostic procedures should, therefore, be evaluated with regard to preexisting pathologies, such as glaucoma. © 2018 S. Karger AG, Basel.

Entropic forces in Brownian motion

NASA Astrophysics Data System (ADS)

Roos, Nico

2014-12-01

Interest in the concept of entropic forces has risen considerably since Verlinde proposed in 2011 to interpret the force in Newton's second law and gravity as entropic forces. Brownian motion—the motion of a small particle (pollen) driven by random impulses from the surrounding molecules—may be the first example of a stochastic process in which such forces are expected to emerge. In this article, it is shown that at least two types of entropic force can be identified in three-dimensional Brownian motion. This analysis yields simple derivations of known results of Brownian motion, Hooke's law, and—applying an external (non-radial) force—Curie's law and the Langevin-Debye equation.

External foam layers to football helmets reduce head impact severity.

PubMed

Nakatsuka, Austin S; Yamamoto, Loren G

2014-08-01

Current American football helmet design has a rigid exterior with a padded interior. Softening the hard external layer of the helmet may reduce the impact potential of the helmet, providing extra head protection and reducing its use as an offensive device. The objective of this study is to measure the impact reduction potential provided by external foam. We obtained a football helmet with built-in accelerometer-based sensors, placed it on a boxing mannequin and struck it with a weighted swinging pendulum helmet to mimic the forces sustained during a helmet-to-helmet strike. We then applied layers of 1.3 cm thick polyolefin foam to the exterior surface of the helmets and repeated the process. All impact severity measures were significantly reduced with the application of the external foam. These results support the hypothesis that adding a soft exterior layer reduces the force of impact which may be applicable to the football field. Redesigning football helmets could reduce the injury potential of the sport.

External Foam Layers to Football Helmets Reduce Head Impact Severity

PubMed Central

Nakatsuka, Austin S

2014-01-01

Current American football helmet design has a rigid exterior with a padded interior. Softening the hard external layer of the helmet may reduce the impact potential of the helmet, providing extra head protection and reducing its use as an offensive device. The objective of this study is to measure the impact reduction potential provided by external foam. We obtained a football helmet with built-in accelerometer-based sensors, placed it on a boxing mannequin and struck it with a weighted swinging pendulum helmet to mimic the forces sustained during a helmet-to-helmet strike. We then applied layers of 1.3 cm thick polyolefin foam to the exterior surface of the helmets and repeated the process. All impact severity measures were significantly reduced with the application of the external foam. These results support the hypothesis that adding a soft exterior layer reduces the force of impact which may be applicable to the football field. Redesigning football helmets could reduce the injury potential of the sport. PMID:25157327

Designing an experiment to measure cellular interaction forces

NASA Astrophysics Data System (ADS)

McAlinden, Niall; Glass, David G.; Millington, Owain R.; Wright, Amanda J.

2013-09-01

Optical trapping is a powerful tool in Life Science research and is becoming common place in many microscopy laboratories and facilities. The force applied by the laser beam on the trapped object can be accurately determined allowing any external forces acting on the trapped object to be deduced. We aim to design a series of experiments that use an optical trap to measure and quantify the interaction force between immune cells. In order to cause minimum perturbation to the sample we plan to directly trap T cells and remove the need to introduce exogenous beads to the sample. This poses a series of challenges and raises questions that need to be answered in order to design a set of effect end-point experiments. A typical cell is large compared to the beads normally trapped and highly non-uniform - can we reliably trap such objects and prevent them from rolling and re-orientating? In this paper we show how a spatial light modulator can produce a triple-spot trap, as opposed to a single-spot trap, giving complete control over the object's orientation and preventing it from rolling due, for example, to Brownian motion. To use an optical trap as a force transducer to measure an external force you must first have a reliably calibrated system. The optical trapping force is typically measured using either the theory of equipartition and observing the Brownian motion of the trapped object or using an escape force method, e.g. the viscous drag force method. In this paper we examine the relationship between force and displacement, as well as measuring the maximum displacement from equilibrium position before an object falls out of the trap, hence determining the conditions under which the different calibration methods should be applied.

A many-body dissipative particle dynamics study of forced water-oil displacement in capillary.

PubMed

Chen, Chen; Zhuang, Lin; Li, Xuefeng; Dong, Jinfeng; Lu, Juntao

2012-01-17

The forced water-oil displacement in capillary is a model that has important applications such as the groundwater remediation and the oil recovery. Whereas it is difficult for experimental studies to observe the displacement process in a capillary at nanoscale, the computational simulation is a unique approach in this regard. In the present work, the many-body dissipative particle dynamics (MDPD) method is employed to simulate the process of water-oil displacement in capillary with external force applied by a piston. As the property of all interfaces involved in this system can be manipulated independently, the dynamic displacement process is studied systematically under various conditions of distinct wettability of water in capillary and miscibility between water and oil as well as of different external forces. By analyzing the dependence of the starting force on the properties of water/capillary and water/oil interfaces, we find that there exist two different modes of the water-oil displacement. In the case of stronger water-oil interaction, the water particles cannot displace those oil particles sticking to the capillary wall, leaving a low oil recovery efficiency. To minimize the residual oil content in capillary, enhancing the wettability of water and reducing the external force will be beneficial. This simulation study provides microscopic insights into the water-oil displacement process in capillary and guiding information for relevant applications. © 2011 American Chemical Society

Robotic Tactile Sensors Fabricated from a Monolithic Silicon Integrated Circuit and a Piezoelectric Polyvinylidene Fluoride Thin Film

DTIC Science & Technology

1991-12-01

gradient will be presented. -Finally, a brief discussion of various piezoelectric materials will be presented, including Rochelle salt, quartz, barium...consideringr a microscopic-level dipole arrangement. The strain induced by ain external force or a tempem at ure gradient changes hie orientation of the...pyroelectric materials, an externally applied temperature gradient can be related to the resulting polarization by a l)yroelectric * constant.1 p (130

Protein displacements under external forces: An atomistic Langevin dynamics approach.

PubMed

Gnandt, David; Utz, Nadine; Blumen, Alexander; Koslowski, Thorsten

2009-02-28

We present a fully atomistic Langevin dynamics approach as a method to simulate biopolymers under external forces. In the harmonic regime, this approach permits the computation of the long-term dynamics using only the eigenvalues and eigenvectors of the Hessian matrix of second derivatives. We apply this scheme to identify polymorphs of model proteins by their mechanical response fingerprint, and we relate the averaged dynamics of proteins to their biological functionality, with the ion channel gramicidin A, a phosphorylase, and neuropeptide Y as examples. In an environment akin to dilute solutions, even small proteins show relaxation times up to 50 ns. Atomically resolved Langevin dynamics computations have been performed for the stretched gramicidin A ion channel.

Stress analysis under component relative interference fit

NASA Technical Reports Server (NTRS)

Taylor, C. M.

1978-01-01

Finite-element computer program enables analysis of distortions and stresses occurring in components having relative interference. Program restricts itself to simple elements and axisymmetric loading situations. External inertial and thermal loads may be applied in addition to forces arising from interference conditions.

Dynamic behavior and deformation analysis of the fish cage system using mass-spring model

NASA Astrophysics Data System (ADS)

Lee, Chun Woo; Lee, Jihoon; Park, Subong

2015-06-01

Fish cage systems are influenced by various oceanic conditions, and the movements and deformation of the system by the external forces can affect the safety of the system itself, as well as the species of fish being cultivated. Structural durability of the system against environmental factors has been major concern for the marine aquaculture system. In this research, a mathematical model and a simulation method were presented for analyzing the performance of the large-scale fish cage system influenced by current and waves. The cage system consisted of netting, mooring ropes, floats, sinkers and floating collar. All the elements were modeled by use of the mass-spring model. The structures were divided into finite elements and mass points were placed at the mid-point of each element, and mass points were connected by springs without mass. Each mass point was applied to external and internal forces, and total force was calculated in every integration step. The computation method was applied to the dynamic simulation of the actual fish cage systems rigged with synthetic fiber and copper wire simultaneously influenced by current and waves. Here, we also tried to find a relevant ratio between buoyancy and sinking force of the fish cages. The simulation results provide improved understanding of the behavior of the structure and valuable information concerning optimum ratio of the buoyancy to sinking force according to current speeds.

Closed loop problems in biomechanics. Part II--an optimization approach.

PubMed

Vaughan, C L; Hay, J G; Andrews, J G

1982-01-01

A closed loop problem in biomechanics may be defined as a problem in which there are one or more closed loops formed by the human body in contact with itself or with an external system. Under certain conditions the problem is indeterminate--the unknown forces and torques outnumber the equations. Force transducing devices, which would help solve this problem, have serious drawbacks, and existing methods are inaccurate and non-general. The purposes of the present paper are (1) to develop a general procedure for solving closed loop problems; (2) to illustrate the application of the procedure; and (3) to examine the validity of the procedure. A mathematical optimization approach is applied to the solution of three different closed loop problems--walking up stairs, vertical jumping and cartwheeling. The following conclusions are drawn: (1) the method described is reasonably successful for predicting horizontal and vertical reaction forces at the distal segments although problems exist for predicting the points of application of these forces; (2) the results provide some support for the notion that the human neuromuscular mechanism attempts to minimize the joint torques and thus, to a certain degree, the amount of muscular effort; (3) in the validation procedure it is desirable to have a force device for each of the distal segments in contact with a fixed external system; and (4) the method is sufficiently general to be applied to all classes of closed loop problems.

Specific interpretation of augmented feedback changes motor performance and cortical processing.

PubMed

Lauber, Benedikt; Keller, Martin; Leukel, Christian; Gollhofer, Albert; Taube, Wolfgang

2013-05-01

It is well established that the presence of external feedback, also termed augmented feedback, can be used to improve performance of a motor task. The present study aimed to elucidate whether differential interpretation of the external feedback signal influences the time to task failure of a sustained submaximal contraction and modulates motor cortical activity. In Experiment 1, subjects had to maintain a submaximal contraction (30% of maximum force) performed with their thumb and index finger. Half of the tested subjects were always provided with feedback about joint position (pF-group), whereas the other half of the subjects were always provided with feedback about force (fF-group). Subjects in the pF-group were led to belief in half of their trials that they would receive feedback about the applied force, and subjects in the fF-group to receive feedback about the position. In both groups (fF and pF), the time to task failure was increased when subjects thought to receive feedback about the force. In Experiment 2, subthreshold transcranial magnetic stimulation was applied over the right motor cortex and revealed an increased motor cortical activity when subjects thought to receive feedback about the joint position. The results showed that the interpretation of feedback influences motor behavior and alters motor cortical activity. The current results support previous studies suggesting a distinct neural control of force and position.

Effect of proline kinks on the mechanical unfolding of α-helices

NASA Astrophysics Data System (ADS)

Arteca, Gustavo A.; Li, Zhiying

2004-12-01

Proteins unfold by applying an external force, although the microscopic mechanism is still not well understood. In this work, we use steered molecular dynamics to probe fundamental aspects of the stretching transition of α-helices, in particular how proline kinks and side chain dynamics would influence their ability to resist the applied force. We find that proline residues effectively 'cut' a helix in half when introduced on stable homopolymers, whereas their effect is smaller when present in helices that are more easily deformed. Our findings provide insight into the factors that may regulate the mechanical stretching of realistic protein domains.

Visco-Resistive MHD Modeling Benchmark of Forced Magnetic Reconnection

NASA Astrophysics Data System (ADS)

Beidler, M. T.; Hegna, C. C.; Sovinec, C. R.; Callen, J. D.; Ferraro, N. M.

2016-10-01

The presence of externally-applied 3D magnetic fields can affect important phenomena in tokamaks, including mode locking, disruptions, and edge localized modes. External fields penetrate into the plasma and can lead to forced magnetic reconnection (FMR), and hence magnetic islands, on resonant surfaces if the local plasma rotation relative to the external field is slow. Preliminary visco-resistive MHD simulations of FMR in a slab geometry are consistent with theory. Specifically, linear simulations exhibit proper scaling of the penetrated field with resistivity, viscosity, and flow, and nonlinear simulations exhibit a bifurcation from a flow-screened to a field-penetrated, magnetic island state as the external field is increased, due to the 3D electromagnetic force. These results will be compared to simulations of FMR in a circular cross-section, cylindrical geometry by way of a benchmark between the NIMROD and M3D-C1 extended-MHD codes. Because neither this geometry nor the MHD model has the physics of poloidal flow damping, the theory of will be expanded to include poloidal flow effects. The resulting theory will be tested with linear and nonlinear simulations that vary the resistivity, viscosity, flow, and external field. Supported by OFES DoE Grants DE-FG02-92ER54139, DE-FG02-86ER53218, DE-AC02-09CH11466, and the SciDAC Center for Extended MHD Modeling.

Compression asphyxia in upright suspended position.

PubMed

Tumram, Nilesh Keshav; Ambade, Vipul Namdeorao; Dixit, Pradeep Gangadhar

2014-06-01

In compression asphyxia, the respiration is prevented by external pressure on the body. It is usually due to external force compressing the trunk due to heavy weight over chest/abdomen and is associated with internal injuries. In the present case, the victim was suspended in an upright position owing to wedging of the chest and the abdomen in the gap between 2 parallel bridges undergoing construction. There was neither any heavy weight over the body, nor was any external force applied over the trunk. Moreover, there was neither any severe blunt force injury nor any significant pathological natural disease contributing to the cause of death. The body was wedged in the gap between 2 static hard surfaces. The victim was unable to extricate himself from the position owing to impairment of cognitive responses and coordination due to influence of alcohol. The victim died as a result of "static" asphyxia due to compression of the chest and the abdomen. Compression asphyxia in upright suspended position under this circumstance is very rare and not reported previously to the best of our knowledge.

Focal contacts as mechanosensors: externally applied local mechanical force induces growth of focal contacts by an mDia1-dependent and ROCK-independent mechanism.

PubMed

Riveline, D; Zamir, E; Balaban, N Q; Schwarz, U S; Ishizaki, T; Narumiya, S; Kam, Z; Geiger, B; Bershadsky, A D

2001-06-11

The transition of cell-matrix adhesions from the initial punctate focal complexes into the mature elongated form, known as focal contacts, requires GTPase Rho activity. In particular, activation of myosin II-driven contractility by a Rho target known as Rho-associated kinase (ROCK) was shown to be essential for focal contact formation. To dissect the mechanism of Rho-dependent induction of focal contacts and to elucidate the role of cell contractility, we applied mechanical force to vinculin-containing dot-like adhesions at the cell edge using a micropipette. Local centripetal pulling led to local assembly and elongation of these structures and to their development into streak-like focal contacts, as revealed by the dynamics of green fluorescent protein-tagged vinculin or paxillin and interference reflection microscopy. Inhibition of Rho activity by C3 transferase suppressed this force-induced focal contact formation. However, constitutively active mutants of another Rho target, the formin homology protein mDia1 (Watanabe, N., T. Kato, A. Fujita, T. Ishizaki, and S. Narumiya. 1999. Nat. Cell Biol. 1:136-143), were sufficient to restore force-induced focal contact formation in C3 transferase-treated cells. Force-induced formation of the focal contacts still occurred in cells subjected to myosin II and ROCK inhibition. Thus, as long as mDia1 is active, external tension force bypasses the requirement for ROCK-mediated myosin II contractility in the induction of focal contacts. Our experiments show that integrin-containing focal complexes behave as individual mechanosensors exhibiting directional assembly in response to local force.

Role of gravity in preparative electrophoresis

NASA Technical Reports Server (NTRS)

Bier, M.

1975-01-01

The fundamental formulas of electrophoresis are derived microscopically and applied to the problem of isotachophoresis. A simple physical model of the isotachophoresis front is proposed. The front motion and structure are studied in the simplified case without convection, diffusion and non-electric external forces.

Force application during handcycling and handrim wheelchair propulsion: an initial comparison.

PubMed

Arnet, Ursina; van Drongelen, Stefan; Veeger, D H; van der Woude L, H V

2013-12-01

The aim of the study was to evaluate the external applied forces, the effectiveness of force application and the net shoulder moments of handcycling in comparison with handrim wheelchair propulsion at different inclines. Ten able-bodied men performed standardized exercises on a treadmill at inclines of 1%, 2.5% and 4% with an instrumented handbike and wheelchair that measured three-dimensional propulsion forces. The results showed that during handcycling significantly lower mean forces were applied at inclines of 2.5% (P < .001) and 4% (P < .001) and significantly lower peak forces were applied at all inclines (1%: P = .014, 2.5% and 4%: P < .001). At the 2.5% incline, where power output was the same for both devices, total forces (mean over trial) of 22.8 N and 27.5 N and peak forces of 40.1 N and 106.9 N were measured for handbike and wheelchair propulsion. The force effectiveness did not differ between the devices (P = .757); however, the effectiveness did increase with higher inclines during handcycling whereas it stayed constant over all inclines for wheelchair propulsion. The resulting peak net shoulder moments were lower for handcycling compared with wheelchair propulsion at all inclines (P < .001). These results confirm the assumption that handcycling is physically less straining.

Safe-haven locking device

DOEpatents

Williams, J.V.

1984-04-26

Disclosed is a locking device for eliminating external control of a secured space formed by fixed and movable barriers. The locking device uses externally and internally controlled locksets and a movable strike, operable from the secured side of the movable barrier, to selectively engage either lockset. A disengagement device, for preventing forces from being applied to the lock bolts is also disclosed. In this manner, a secured space can be controlled from the secured side as a safe-haven. 4 figures.

Determining polarizable force fields with electrostatic potentials from quantum mechanical linear response theory

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wang, Hao; Yang, Weitao, E-mail: weitao.yang@duke.edu; Department of Physics, Duke University, Durham, North Carolina 27708

We developed a new method to calculate the atomic polarizabilities by fitting to the electrostatic potentials (ESPs) obtained from quantum mechanical (QM) calculations within the linear response theory. This parallels the conventional approach of fitting atomic charges based on electrostatic potentials from the electron density. Our ESP fitting is combined with the induced dipole model under the perturbation of uniform external electric fields of all orientations. QM calculations for the linear response to the external electric fields are used as input, fully consistent with the induced dipole model, which itself is a linear response model. The orientation of the uniformmore » external electric fields is integrated in all directions. The integration of orientation and QM linear response calculations together makes the fitting results independent of the orientations and magnitudes of the uniform external electric fields applied. Another advantage of our method is that QM calculation is only needed once, in contrast to the conventional approach, where many QM calculations are needed for many different applied electric fields. The molecular polarizabilities obtained from our method show comparable accuracy with those from fitting directly to the experimental or theoretical molecular polarizabilities. Since ESP is directly fitted, atomic polarizabilities obtained from our method are expected to reproduce the electrostatic interactions better. Our method was used to calculate both transferable atomic polarizabilities for polarizable molecular mechanics’ force fields and nontransferable molecule-specific atomic polarizabilities.« less

Selective Effects of Training Against Weight and Inertia on Muscle Mechanical Properties.

PubMed

Djuric, Sasa; Cuk, Ivan; Sreckovic, Sreten; Mirkov, Dragan; Nedeljkovic, Aleksandar; Jaric, Slobodan

2016-10-01

To explore the effects of training against mechanically different types of loads on muscle force (F), velocity (V), and power (P) outputs. Subjects practiced maximum bench throws over 8 wk against a bar predominantly loaded by approximately constant external force (weight), weight plates (weight plus inertia), or weight plates whose weight was compensated by a constant external force pulling upward (inertia). Instead of a typically applied single trial performed against a selected load, the pretest and posttest consisted of the same task performed against 8 different loads ranging from 30% to 79% of the subject's maximum strength applied by adding weight plates to the bar. That provided a range of F and V data for subsequent modeling by linear F-V regression revealing the maximum F (F-intercept), V (V-intercept), and P (P = FV/4). Although all 3 training conditions resulted in increased P, the inertia type of the training load could be somewhat more effective than weight. An even more important finding was that the P increase could be almost exclusively based on a gain in F, V, or both when weight, inertia, or weight-plus-inertia training load were applied, respectively. The inertia training load is more effective than weight in increasing P and weight and inertia may be applied for selective gains in F and V, respectively, whereas the linear F-V model obtained from loaded trials could be used for discerning among muscle F, V, and P.

Instabilities of conducting fluid flows in cylindrical shells under external forcing

NASA Astrophysics Data System (ADS)

Burguete, Javier; Miranda, Montserrat

2010-11-01

Flows created in neutral conducting flows remain one of the less studied topics of fluid dynamics, in spite of their relevance both in fundamental research (dynamo action, turbulence suppression) and applications (continuous casting, aluminium production, biophysics). Here we present the effect of a time-dependent magnetic field parallel to the axis of circular cavities. Due to the Lenz's law, the time-dependent magnetic field generates an azymuthal current, that produces a radial force. This force produces the destabilization of the static fluid layer, and a flow is created. The geommetry of the experimental cell is a disc layer with external diameter smaller than 94 mm, with or without internal hole. The layer is up to 20mm depth, and we use as conducting fluid an In-Ga-Sn alloy. There is no external current applied on the problem, only an external magnetic field. This field evolves harmonically with a frequency up to 10Hz, small enough to not to observe skin depth effects. The magnitude ranges from 0 to 0.1 T. With a threshold of 0.01T a dynamical behaviour is observed, and the main characteristics of this flow have been determined: different temporal resonances and spatial patterns with differents symmetries (squares, hexagonal, triangles,...).

Photoinduced reversible lattice expansion in W-doped TiO2 through the change of its electronic structure

NASA Astrophysics Data System (ADS)

Feng, Fan; Yang, Weiyi; Gao, Shuang; Zhu, Linggang; Li, Qi

2018-02-01

External stimulations of applied force or voltage have been reported to induce crystal lattice dimension changes with the order of 0.1% or above by imposing external mechanical or electric forces on atoms forming the lattice for various types of materials, including oxides, metals, polymers, and carbon nanostructures. As far as we know, however, no report is available for similar level changes in oxides from their internal electronic structure changes induced by photoirradiation. We show that reversible lattice expansion comparable to those by applied force or voltage can be induced by UV-irradiation on an oxide of W-doped TiO2 nanotubes through the reversible changes of its internal electronic structure by the accumulation and release of photogenerated electrons in W-dopants when UV-illumination is on and off. This photoirradiation-induced reversible lattice expansion and subsequent optical, electric, and magnetic property changes may also be present in other material systems by proper material design if they possess one component that is able to produce electrons upon photoirradiation and the other component that is able to accumulate photogenerated electrons to induce lattice changes and release them after the photoirradiation is off.

Loading of the Medial Meniscus in the ACL deficient knee: a Multibody Computational Study

PubMed Central

Razu, Swithin

2017-01-01

The menisci of the knee reduce tibiofemoral contact pressures and aid in knee lubrication and nourishment. Meniscal injury occurs in half of knees sustaining anterior cruciate ligament injury and the vast majority of tears in the medial meniscus transpire in the posterior horn region. In this study, computational multibody models of the knee were derived from medical images and passive leg motion for two female subjects. The models were validated against experimental measures available in the literature and then used to evaluate medial meniscus contact force and internal hoop tension. The models predicted that the loss of anterior cruciate ligament (ACL) constraint increased contact and hoop forces in the medial menisci by a factor of 4 when a 100 N anterior tibial force was applied. Contact forces were concentrated in the posterior horn and hoop forces were also greater in this region. No differences were found in contact or hoop tension between the intact and ACL deficient (ACLd) knees when only a 5 Nm external tibial torque was applied about the long axis of the tibia. Combining a 100 N anterior tibial force and a 5 Nm external tibial torque increased posterior horn contact and hoop forces, even in the intact knee. The results of this study show that the posterior horn region of the medial meniscus experiences higher contact forces and hoop tension, making this region more susceptible to injury, especially with the loss of anterior tibia motion constraint provided by the ACL. The contribution of the dMCL in constraining posterior medial meniscus motion, at the cost of higher posterior horn hoop tension, is also demonstrated. PMID:28089224

Loading of the medial meniscus in the ACL deficient knee: A multibody computational study.

PubMed

Guess, Trent M; Razu, Swithin

2017-03-01

The menisci of the knee reduce tibiofemoral contact pressures and aid in knee lubrication and nourishment. Meniscal injury occurs in half of knees sustaining anterior cruciate ligament injury and the vast majority of tears in the medial meniscus transpire in the posterior horn region. In this study, computational multibody models of the knee were derived from medical images and passive leg motion for two female subjects. The models were validated against experimental measures available in the literature and then used to evaluate medial meniscus contact force and internal hoop tension. The models predicted that the loss of anterior cruciate ligament (ACL) constraint increased contact and hoop forces in the medial menisci by a factor of 4 when a 100N anterior tibial force was applied. Contact forces were concentrated in the posterior horn and hoop forces were also greater in this region. No differences were found in contact or hoop tension between the intact and ACL deficient (ACLd) knees when only a 5Nm external tibial torque was applied about the long axis of the tibia. Combining a 100N anterior tibial force and a 5Nm external tibial torque increased posterior horn contact and hoop forces, even in the intact knee. The results of this study show that the posterior horn region of the medial meniscus experiences higher contact forces and hoop tension, making this region more susceptible to injury, especially with the loss of anterior tibia motion constraint provided by the ACL. The contribution of the dMCL in constraining posterior medial meniscus motion, at the cost of higher posterior horn hoop tension, is also demonstrated. Copyright © 2016 IPEM. Published by Elsevier Ltd. All rights reserved.

Development of a Network Analysis of the Air Force Provisioning Process for an Applied Computer Simulation Exercise.

DTIC Science & Technology

1984-09-01

everything from strategic force allocations to leadership role-playing; but there are only a few exercises in existence for management gaming. In the... reported that Shade and Paine (1975) found declines in political cynicism were produced more effectively through simulation than through conventional...effectiveness of business games through external validation was unsuccessful. In their study, career success was used as the dependent variable and was

Active vibrations and noise control for turboprop application research program activities

NASA Technical Reports Server (NTRS)

Paonessa, A.; Concilio, A.; Lecce, Leonardo V.

1992-01-01

The objectives of this work include the following: (1) development of active noise control techniques to alleviate inefficiencies and drawbacks of passive noise control approach especially at low frequencies; (2) reduction of structurally radiated noise applying external forces to the vibrating structure by means of force actuators made of piezoelectric material; and (3) reduction of fuselage vibration levels in propeller driven aircraft by means of distributed piezoelectric actuators that are actively controlled.

Active vibrations and noise control for turboprop application research program activities

NASA Astrophysics Data System (ADS)

Paonessa, A.; Concilio, A.; Lecce, Leonardo V.

1992-07-01

The objectives of this work include the following: (1) development of active noise control techniques to alleviate inefficiencies and drawbacks of passive noise control approach especially at low frequencies; (2) reduction of structurally radiated noise applying external forces to the vibrating structure by means of force actuators made of piezoelectric material; and (3) reduction of fuselage vibration levels in propeller driven aircraft by means of distributed piezoelectric actuators that are actively controlled.

TIGER: Development of Thermal Gradient Compensation Algorithms and Techniques

NASA Technical Reports Server (NTRS)

Hereford, James; Parker, Peter A.; Rhew, Ray D.

2004-01-01

In a wind tunnel facility, the direct measurement of forces and moments induced on the model are performed by a force measurement balance. The measurement balance is a precision-machined device that has strain gages at strategic locations to measure the strain (i.e., deformations) due to applied forces and moments. The strain gages convert the strain (and hence the applied force) to an electrical voltage that is measured by external instruments. To address the problem of thermal gradients on the force measurement balance NASA-LaRC has initiated a research program called TIGER - Thermally-Induced Gradients Effects Research. The ultimate goals of the TIGER program are to: (a) understand the physics of the thermally-induced strain and its subsequent impact on load measurements and (b) develop a robust thermal gradient compensation technique. This paper will discuss the impact of thermal gradients on force measurement balances, specific aspects of the TIGER program (the design of a special-purpose balance, data acquisition and data analysis challenges), and give an overall summary.

Load identification approach based on basis pursuit denoising algorithm

NASA Astrophysics Data System (ADS)

Ginsberg, D.; Ruby, M.; Fritzen, C. P.

2015-07-01

The information of the external loads is of great interest in many fields of structural analysis, such as structural health monitoring (SHM) systems or assessment of damage after extreme events. However, in most cases it is not possible to measure the external forces directly, so they need to be reconstructed. Load reconstruction refers to the problem of estimating an input to a dynamic system when the system output and the impulse response functions are usually the knowns. Generally, this leads to a so called ill-posed inverse problem, which involves solving an underdetermined linear system of equations. For most practical applications it can be assumed that the applied loads are not arbitrarily distributed in time and space, at least some specific characteristics about the external excitation are known a priori. In this contribution this knowledge was used to develop a more suitable force reconstruction method, which allows identifying the time history and the force location simultaneously by employing significantly fewer sensors compared to other reconstruction approaches. The properties of the external force are used to transform the ill-posed problem into a sparse recovery task. The sparse solution is acquired by solving a minimization problem known as basis pursuit denoising (BPDN). The possibility of reconstructing loads based on noisy structural measurement signals will be demonstrated by considering two frequently occurring loading conditions: harmonic excitation and impact events, separately and combined. First a simulation study of a simple plate structure is carried out and thereafter an experimental investigation of a real beam is performed.

Development of devices for self-injection: using tribological analysis to optimize injection force

PubMed Central

Lange, Jakob; Urbanek, Leos; Burren, Stefan

2016-01-01

This article describes the use of analytical models and physical measurements to characterize and optimize the tribological behavior of pen injectors for self-administration of biopharmaceuticals. One of the main performance attributes of this kind of device is its efficiency in transmitting the external force applied by the user on to the cartridge inside the pen in order to effectuate an injection. This injection force characteristic is heavily influenced by the frictional properties of the polymeric materials employed in the mechanism. Standard friction tests are available for characterizing candidate materials, but they use geometries and conditions far removed from the actual situation inside a pen injector and thus do not always generate relevant data. A new test procedure, allowing the direct measurement of the coefficient of friction between two key parts of a pen injector mechanism using real parts under simulated use conditions, is presented. In addition to the absolute level of friction, the test method provides information on expected evolution of friction over lifetime as well as on expected consistency between individual devices. Paired with an analytical model of the pen mechanism, the frictional data allow the expected overall injection system force efficiency to be estimated. The test method and analytical model are applied to a range of polymer combinations with different kinds of lubrication. It is found that material combinations used without lubrication generally have unsatisfactory performance, that the use of silicone-based internal lubricating additives improves performance, and that the best results can be achieved with external silicone-based lubricants. Polytetrafluoroethylene-based internal lubrication and external lubrication are also evaluated but found to provide only limited benefits unless used in combination with silicone. PMID:27274319

Production of ZrC Matrix for Use in Gas Fast Reactor Composite Fuels

DOE Office of Scientific and Technical Information (OSTI.GOV)

Vasudevamurthy, Gokul; Knight, Travis W.; Roberts, Elwyn

2007-07-01

Zirconium carbide is being considered as a candidate for inert matrix material in composite nuclear fuel for Gas fast reactors due to its favorable characteristics. ZrC can be produced by the direct reaction of pure zirconium and graphite powders. Such a reaction is exothermic in nature. The reaction is self sustaining once initial ignition has been achieved. The heat released during the reaction is high enough to complete the reaction and achieve partial sintering without any external pressure applied. External heat source is required to achieve ignition of the reactants and maintain the temperature close to the adiabatic temperature tomore » achieve higher levels of sintering. External pressure is also a driving force for sintering. In the experiments described, cylindrical compacts of ZrC were produced by direct combustion reaction. External induction heating combined with varying amounts of external applied pressure was employed to achieve varying degrees of density/porosity. The effect of reactant particle size on the product characteristics was also studied. The samples were characterized for density/porosity, composition and microstructure. (authors)« less

Evaluation of a load cell model for dynamic calibration of the rotor systems research aircraft

NASA Technical Reports Server (NTRS)

Duval, R. W.; Bahrami, H.; Wellman, B.

1985-01-01

The Rotor Systems Research Aircraft uses load cells to isolate the rotor/transmission system from the fuselage. An analytical model of the relationship between applied rotor loads and the resulting load cell measurements is derived by applying a force-and-moment balance to the isolated rotor/transmission system. The model is then used to estimate the applied loads from measured load cell data, as obtained from a ground-based shake test. Using nominal design values for the parameters, the estimation errors, for the case of lateral forcing, were shown to be on the order of the sensor measurement noise in all but the roll axis. An unmodeled external load appears to be the source of the error in this axis.

Effects of a powered ankle-foot prosthesis on kinetic loading of the unaffected leg during level-ground walking

PubMed Central

2013-01-01

Background People with a lower-extremity amputation that use conventional passive-elastic ankle-foot prostheses encounter a series of stress-related challenges during walking such as greater forces on their unaffected leg, and may thus be predisposed to secondary musculoskeletal injuries such as chronic joint disorders. Specifically, people with a unilateral transtibial amputation have an increased susceptibility to knee osteoarthritis, especially in their unaffected leg. Previous studies have hypothesized that the development of this disorder is linked to the abnormally high peak knee external adduction moments encountered during walking. An ankle-foot prosthesis that supplies biomimetic power could potentially mitigate the forces and knee adduction moments applied to the unaffected leg of a person with a transtibial amputation, which could, in turn, reduce the risk of knee osteoarthritis. We hypothesized that compared to using a passive-elastic prosthesis, people with a transtibial amputation using a powered ankle-foot prosthesis would have lower peak resultant ground reaction forces, peak external knee adduction moments, and corresponding loading rates applied to their unaffected leg during walking over a wide range of speeds. Methods We analyzed ground reaction forces and knee joint kinetics of the unaffected leg of seven participants with a unilateral transtibial amputation and seven age-, height- and weight-matched non-amputees during level-ground walking at 0.75, 1.00, 1.25, 1.50, and 1.75 m/s. Subjects with an amputation walked while using their own passive-elastic prosthesis and a powered ankle-foot prosthesis capable of providing net positive mechanical work and powered ankle plantar flexion during late stance. Results Use of the powered prosthesis significantly decreased unaffected leg peak resultant forces by 2-11% at 0.75-1.50 m/s, and first peak knee external adduction moments by 21 and 12% at 1.50 and 1.75 m/s, respectively. Loading rates were not significantly different between prosthetic feet. Conclusions Use of a biomimetic powered ankle-foot prosthesis decreased peak resultant force at slow and moderate speeds and knee external adduction moment at moderate and fast speeds on the unaffected leg of people with a transtibial amputation during level-ground walking. Thus, use of an ankle-foot prosthesis that provides net positive mechanical work could reduce the risk of comorbidities such as knee osteoarthritis. PMID:23758860

Piezoelectric Pre-Stressed Bending Mechanism for Impact-Driven Energy Harvester

NASA Astrophysics Data System (ADS)

Abdal, A. M.; Leong, K. S.

2017-06-01

This paper experimentally demonstrates and evaluates a piezoelectric power generator bending mechanism based on pre-stressed condition whereby the piezoelectric transducer being bended and remained in the stressed condition before applying a force on the piezoelectric bending structure, which increase the stress on the piezoelectric surface and hence increase the generated electrical charges. An impact force is being exerted onto bending the piezoelectric beam and hence generating electrical power across an external resistive load. The proposed bending mechanism prototype has been manufactured by employing 3D printer technology in order to conduct the evaluation. A free fall test has been conducted as the evaluation method with varying force using a series of different masses and different fall heights. A rectangular piezoelectric harvester beam with the size of 32mm in width, 70mm in length, and 0.55mm in thickness is used to demonstrate the experiment. It can be seen from the experiment that the instantaneous peak to peak AC volt output measured at open-circuit is increasing and saturated at about of 70V when an impact force of about 80N is being applied. It is also found that a maximum power of about 53mW is generated at an impact force of 50N when it is connected to an external resistive load of 0.7KΩ. The reported mechanism is a promising candidate in the application of energy harvesting for powering various wireless sensor nodes (WSN) which is the core of Internet of Things (IoT).

A Progression of Static Equilibrium Laboratory Exercises

NASA Astrophysics Data System (ADS)

Kutzner, Mickey; Kutzner, Andrew

2013-10-01

Although simple architectural structures like bridges, catwalks, cantilevers, and Stonehenge have been integral in human societies for millennia, as have levers and other simple tools, modern students of introductory physics continue to grapple with Newton's conditions for static equilibrium. As formulated in typical introductory physics textbooks, these two conditions appear as ΣF=0(1) and Στ=0,(2) where each torque τ is defined as the cross product between the lever arm vector r and the corresponding applied force F, τ =r×F,(3) having magnitude, τ =Frsinθ.(4) The angle θ here is between the two vectors F and r. In Eq. (1), upward (downward) forces are considered positive (negative). In Eq. (2), counterclockwise (clockwise) torques are considered positive (negative). Equation (1) holds that the vector sum of the external forces acting on an object must be zero to prevent linear accelerations; Eq. (2) states that the vector sum of torques due to external forces about any axis must be zero to prevent angular accelerations. In our view these conditions can be problematic for students because a) the equations contain the unfamiliar summation notation Σ, b) students are uncertain of the role of torques in causing rotations, and c) it is not clear why the sum of torques is zero regardless of the choice of axis. Gianino5 describes an experiment using MBL and a force sensor to convey the meaning of torque as applied to a rigid-body lever system without exploring quantitative aspects of the conditions for static equilibrium.

Inflatable bladder provides accurate calibration of pressure switch

NASA Technical Reports Server (NTRS)

Smith, N. J.

1965-01-01

Calibration of a pressure switch is accurately checked by a thin-walled circular bladder. It is placed in the pressure switch and applies force to the switch diaphragm when expanded by an external pressure source. The disturbance to the normal operation of the switch is minimal.

Are external knee load and EMG measures accurate indicators of internal knee contact forces during gait?

PubMed

Meyer, Andrew J; D'Lima, Darryl D; Besier, Thor F; Lloyd, David G; Colwell, Clifford W; Fregly, Benjamin J

2013-06-01

Mechanical loading is believed to be a critical factor in the development and treatment of knee osteoarthritis. However, the contact forces to which the knee articular surfaces are subjected during daily activities cannot be measured clinically. Thus, the ability to predict internal knee contact forces accurately using external measures (i.e., external knee loads and muscle electromyographic [EMG] signals) would be clinically valuable. We quantified how well external knee load and EMG measures predict internal knee contact forces during gait. A single subject with a force-measuring tibial prosthesis and post-operative valgus alignment performed four gait patterns (normal, medial thrust, walking pole, and trunk sway) to induce a wide range of external and internal knee joint loads. Linear regression analyses were performed to assess how much of the variability in internal contact forces was accounted for by variability in the external measures. Though the different gait patterns successfully induced significant changes in the external and internal quantities, changes in external measures were generally weak indicators of changes in total, medial, and lateral contact force. Our results suggest that when total contact force may be changing, caution should be exercised when inferring changes in knee contact forces based on observed changes in external knee load and EMG measures. Advances in musculoskeletal modeling methods may be needed for accurate estimation of in vivo knee contact forces. Copyright © 2012 Orthopaedic Research Society.

Force measurements in the medial meniscus posterior horn attachment: effects of anterior cruciate ligament removal.

PubMed

Markolf, Keith L; Jackson, Steven R; McAllister, David R

2012-02-01

Tears of the medial meniscus posterior horn attachment (PHA) occur clinically, and an anterior cruciate ligament (ACL)-deficient knee may be more vulnerable to this injury. The PHA forces from applied knee loadings will increase after removal of the ACL. Controlled laboratory study. A cap of bone containing the medial meniscus PHA was attached to a load cell that measured PHA tensile force. Posterior horn attachment forces were recorded before and after ACL removal during anteroposterior (AP) laxity testing at ±200 N and during passive knee extension tests with 5 N·m tibial torque and varus-valgus moment. Selected tests were also performed with 500 N joint load. For AP tests with no joint load, ACL removal increased laxity between 0° and 90° and increased PHA force generated by applied anterior tibial force between 30° and 90°. For AP tests with an intact ACL, application of joint load approximately doubled PHA forces. Anteroposterior testing of ACL-deficient knees was not possible with joint load because of bone cap failures from high PHA forces. Removal of the ACL during knee extension tests under joint load significantly increased PHA forces between 20° and 90° of flexion. For unloaded tests with applied tibial torque and varus-valgus moment, ACL removal had no significant effect on PHA forces. Applied anterior tibial force and external tibial torque were loading modes that produced relatively high PHA forces, presumably by impingement of the medial femoral condyle against the medial meniscus posterior horn rim. Under joint load, an ACL-deficient knee was particularly susceptible to PHA injury from applied anterior tibial force. Because tensile forces developed in the PHA are also borne by meniscus tissue near the attachment site, loading mechanisms that produce high PHA forces could also produce complete or partial radial tears near the posterior horn, a relatively common clinical observation.

Nonlinear Bubble Interactions in Acoustic Pressure Fields

NASA Technical Reports Server (NTRS)

Barbat, Tiberiu; Ashgriz, Nasser; Liu, Ching-Shi

1996-01-01

The systems consisting of a two-phase mixture, as clouds of bubbles or drops, have shown many common features in their responses to different external force fields. One of particular interest is the effect of an unsteady pressure field applied to these systems, case in which the coupling of the vibrations induced in two neighboring components (two drops or two bubbles) may result in an interaction force between them. This behavior was explained by Bjerknes by postulating that every body that is moving in an accelerating fluid is subjected to a 'kinetic buoyancy' equal with the product of the acceleration of the fluid multiplied by the mass of the fluid displaced by the body. The external sound wave applied to a system of drops/bubbles triggers secondary sound waves from each component of the system. These secondary pressure fields integrated over the surface of the neighboring drop/bubble may result in a force additional to the effect of the primary sound wave on each component of the system. In certain conditions, the magnitude of these secondary forces may result in significant changes in the dynamics of each component, thus in the behavior of the entire system. In a system containing bubbles, the sound wave radiated by one bubble at the location of a neighboring one is dominated by the volume oscillation mode and its effects can be important for a large range of frequencies. The interaction forces in a system consisting of drops are much smaller than those consisting of bubbles. Therefore, as a first step towards the understanding of the drop-drop interaction subject to external pressure fluctuations, it is more convenient to study the bubble interactions. This paper presents experimental results and theoretical predictions concerning the interaction and the motion of two levitated air bubbles in water in the presence of an acoustic field at high frequencies (22-23 KHz).

Functional Brace in ACL Surgery: Force Quantification in an In Vivo Study

PubMed Central

LaPrade, Robert F.; Venderley, Melanie B.; Dahl, Kimi D.; Dornan, Grant J.; Turnbull, Travis Lee

2017-01-01

Background: A need exists for a functional anterior cruciate ligament (ACL) brace that dynamically supports the knee joint to match the angle-dependent forces of a native ACL, especially in the early postoperative period. Purpose/Hypothesis: The purpose of this study was to quantify the posteriorly directed external forces applied to the anterior proximal tibia by both a static and a dynamic force ACL brace. The proximal strap forces applied by the static force brace were hypothesized to remain relatively constant regardless of knee flexion angle compared with those of the dynamic force brace. Study Design: Controlled laboratory study. Methods: Seven healthy adult males (mean age, 27.4 ± 3.4 years; mean height, 1.8 ± 0.1 m; mean body mass, 84.1 ± 11.3 kg) were fitted with both a static and a dynamic force ACL brace. Participants completed 3 functional activities: unloaded extension, sit-to-stand, and stair ascent. Kinematic data were collected using traditional motion-capture techniques while posteriorly directed forces applied to the anterior aspect of both the proximal and distal tibia were simultaneously collected using a customized pressure-mapping technique. Results: The mean posteriorly directed forces applied to the proximal tibia at 30° of flexion by the dynamic force brace during unloaded extension (80.2 N), sit-to-stand (57.5 N), and stair ascent (56.3 N) activities were significantly larger, regardless of force setting, than those applied by the static force brace (10.1 N, 9.5 N, and 11.9 N, respectively; P < .001). Conclusion: The dynamic force ACL brace, compared with the static force brace, applied significantly larger posteriorly directed forces to the anterior proximal tibia in extension, where the ACL is known to experience larger in vivo forces. Further studies are required to determine whether the physiological behavior of the brace will reduce anterior knee laxity and improve long-term patient outcomes. Clinical Relevance: ACL braces that dynamically restrain the proximal tibia in a manner similar to physiological ACL function may improve pre- and postoperative treatment. PMID:28748195

Applying torque to the Escherichia coli flagellar motor using magnetic tweezers.

PubMed

van Oene, Maarten M; Dickinson, Laura E; Cross, Bronwen; Pedaci, Francesco; Lipfert, Jan; Dekker, Nynke H

2017-03-07

The bacterial flagellar motor of Escherichia coli is a nanoscale rotary engine essential for bacterial propulsion. Studies on the power output of single motors rely on the measurement of motor torque and rotation under external load. Here, we investigate the use of magnetic tweezers, which in principle allow the application and active control of a calibrated load torque, to study single flagellar motors in Escherichia coli. We manipulate the external load on the motor by adjusting the magnetic field experienced by a magnetic bead linked to the motor, and we probe the motor's response. A simple model describes the average motor speed over the entire range of applied fields. We extract the motor torque at stall and find it to be similar to the motor torque at drag-limited speed. In addition, use of the magnetic tweezers allows us to force motor rotation in both forward and backward directions. We monitor the motor's performance before and after periods of forced rotation and observe no destructive effects on the motor. Our experiments show how magnetic tweezers can provide active and fast control of the external load while also exposing remaining challenges in calibration. Through their non-invasive character and straightforward parallelization, magnetic tweezers provide an attractive platform to study nanoscale rotary motors at the single-motor level.

Applying torque to the Escherichia coli flagellar motor using magnetic tweezers

PubMed Central

van Oene, Maarten M.; Dickinson, Laura E.; Cross, Bronwen; Pedaci, Francesco; Lipfert, Jan; Dekker, Nynke H.

2017-01-01

The bacterial flagellar motor of Escherichia coli is a nanoscale rotary engine essential for bacterial propulsion. Studies on the power output of single motors rely on the measurement of motor torque and rotation under external load. Here, we investigate the use of magnetic tweezers, which in principle allow the application and active control of a calibrated load torque, to study single flagellar motors in Escherichia coli. We manipulate the external load on the motor by adjusting the magnetic field experienced by a magnetic bead linked to the motor, and we probe the motor’s response. A simple model describes the average motor speed over the entire range of applied fields. We extract the motor torque at stall and find it to be similar to the motor torque at drag-limited speed. In addition, use of the magnetic tweezers allows us to force motor rotation in both forward and backward directions. We monitor the motor’s performance before and after periods of forced rotation and observe no destructive effects on the motor. Our experiments show how magnetic tweezers can provide active and fast control of the external load while also exposing remaining challenges in calibration. Through their non-invasive character and straightforward parallelization, magnetic tweezers provide an attractive platform to study nanoscale rotary motors at the single-motor level. PMID:28266562

Dependence of Interaction Free Energy between Solutes on an External Electrostatic Field

PubMed Central

Yang, Pei-Kun

2013-01-01

To explore the athermal effect of an external electrostatic field on the stabilities of protein conformations and the binding affinities of protein-protein/ligand interactions, the dependences of the polar and hydrophobic interactions on the external electrostatic field, −Eext, were studied using molecular dynamics (MD) simulations. By decomposing Eext into, along, and perpendicular to the direction formed by the two solutes, the effect of Eext on the interactions between these two solutes can be estimated based on the effects from these two components. Eext was applied along the direction of the electric dipole formed by two solutes with opposite charges. The attractive interaction free energy between these two solutes decreased for solutes treated as point charges. In contrast, the attractive interaction free energy between these two solutes increased, as observed by MD simulations, for Eext = 40 or 60 MV/cm. Eext was applied perpendicular to the direction of the electric dipole formed by these two solutes. The attractive interaction free energy was increased for Eext = 100 MV/cm as a result of dielectric saturation. The force on the solutes along the direction of Eext computed from MD simulations was greater than that estimated from a continuum solvent in which the solutes were treated as point charges. To explore the hydrophobic interactions, Eext was applied to a water cluster containing two neutral solutes. The repulsive force between these solutes was decreased/increased for Eext along/perpendicular to the direction of the electric dipole formed by these two solutes. PMID:23852018

Mechanical stimulation improves tissue-engineered human skeletal muscle

NASA Technical Reports Server (NTRS)

Powell, Courtney A.; Smiley, Beth L.; Mills, John; Vandenburgh, Herman H.

2002-01-01

Human bioartificial muscles (HBAMs) are tissue engineered by suspending muscle cells in collagen/MATRIGEL, casting in a silicone mold containing end attachment sites, and allowing the cells to differentiate for 8 to 16 days. The resulting HBAMs are representative of skeletal muscle in that they contain parallel arrays of postmitotic myofibers; however, they differ in many other morphological characteristics. To engineer improved HBAMs, i.e., more in vivo-like, we developed Mechanical Cell Stimulator (MCS) hardware to apply in vivo-like forces directly to the engineered tissue. A sensitive force transducer attached to the HBAM measured real-time, internally generated, as well as externally applied, forces. The muscle cells generated increasing internal forces during formation which were inhibitable with a cytoskeleton depolymerizer. Repetitive stretch/relaxation for 8 days increased the HBAM elasticity two- to threefold, mean myofiber diameter 12%, and myofiber area percent 40%. This system allows engineering of improved skeletal muscle analogs as well as a nondestructive method to determine passive force and viscoelastic properties of the resulting tissue.

The Footprint of the Inter-decadal Pacific Oscillation in Indian Ocean Sea Surface Temperatures

NASA Astrophysics Data System (ADS)

Dong, Lu; Zhou, Tianjun; Dai, Aiguo; Song, Fengfei; Wu, Bo; Chen, Xiaolong

2016-02-01

Superimposed on a pronounced warming trend, the Indian Ocean (IO) sea surface temperatures (SSTs) also show considerable decadal variations that can cause regional climate oscillations around the IO. However, the mechanisms of the IO decadal variability remain unclear. Here we perform numerical experiments using a state-of-the-art, fully coupled climate model in which the external forcings with or without the observed SSTs in the tropical eastern Pacific Ocean (TEP) are applied for 1871-2012. Both the observed timing and magnitude of the IO decadal variations are well reproduced in those experiments with the TEP SSTs prescribed to observations. Although the external forcings account for most of the warming trend, the decadal variability in IO SSTs is dominated by internal variability that is induced by the TEP SSTs, especially the Inter-decadal Pacific Oscillation (IPO). The IPO weakens (enhances) the warming of the external forcings by about 50% over the IO during IPO’s cold (warm) phase, which contributes about 10% to the recent global warming hiatus since 1999. The decadal variability in IO SSTs is modulated by the IPO-induced atmospheric adjustment through changing surface heat fluxes, sea surface height and thermocline depth.

The Footprint of the Inter-decadal Pacific Oscillation in Indian Ocean Sea Surface Temperatures.

PubMed

Dong, Lu; Zhou, Tianjun; Dai, Aiguo; Song, Fengfei; Wu, Bo; Chen, Xiaolong

2016-02-17

Superimposed on a pronounced warming trend, the Indian Ocean (IO) sea surface temperatures (SSTs) also show considerable decadal variations that can cause regional climate oscillations around the IO. However, the mechanisms of the IO decadal variability remain unclear. Here we perform numerical experiments using a state-of-the-art, fully coupled climate model in which the external forcings with or without the observed SSTs in the tropical eastern Pacific Ocean (TEP) are applied for 1871-2012. Both the observed timing and magnitude of the IO decadal variations are well reproduced in those experiments with the TEP SSTs prescribed to observations. Although the external forcings account for most of the warming trend, the decadal variability in IO SSTs is dominated by internal variability that is induced by the TEP SSTs, especially the Inter-decadal Pacific Oscillation (IPO). The IPO weakens (enhances) the warming of the external forcings by about 50% over the IO during IPO's cold (warm) phase, which contributes about 10% to the recent global warming hiatus since 1999. The decadal variability in IO SSTs is modulated by the IPO-induced atmospheric adjustment through changing surface heat fluxes, sea surface height and thermocline depth.

Simultaneous Single-Molecule Force and Fluorescence Sampling of DNA Nanostructure Conformations Using Magnetic Tweezers.

PubMed

Kemmerich, Felix E; Swoboda, Marko; Kauert, Dominik J; Grieb, M Svea; Hahn, Steffen; Schwarz, Friedrich W; Seidel, Ralf; Schlierf, Michael

2016-01-13

We present a hybrid single-molecule technique combining magnetic tweezers and Förster resonance energy transfer (FRET) measurements. Through applying external forces to a paramagnetic sphere, we induce conformational changes in DNA nanostructures, which are detected in two output channels simultaneously. First, by tracking a magnetic bead with high spatial and temporal resolution, we observe overall DNA length changes along the force axis. Second, the measured FRET efficiency between two fluorescent probes monitors local conformational changes. The synchronized orthogonal readout in different observation channels will facilitate deciphering the complex mechanisms of biomolecular machines.

Nonlocal Theory for Fracturing of Quasibrittle Materials.

DTIC Science & Technology

1994-03-01

eigenstrain e* be applied to an ellipsoidal domain 0J contained * in this infinite body. The values of the cigenstrain t* are such that the stress is...affecting its stresses and deformation. Thus, the change of potential energy of the infinite body caused by the applied eigenstrain is the same as the...infinite body is subjected to external forces alone or eigenstrain a* alone, respectively. If plane-strain cases are considered, the ellipsoid becomes an

Parameter identification of a rotor supported in a pressurized bearing lubricated with water

NASA Technical Reports Server (NTRS)

Grant, John W.; Muszynska, Agnes; Bently, Donald E.

1994-01-01

A rig for testing an externally pressurized (hydrostatic), water-lubricated bearing was developed. Applying a nonsynchronous sweep frequency, rotating perturbation force with a constant amplitude as an input, rotor vibration response data was acquired in Bode and Dynamic Stiffness formats. Using this data, the parameters of the rotor/bearing system were identified. The rotor/bearing model was represented by the generalized (modal) parameters of the first lateral mode, with the rotational character of the fluid force taken into account.

Error-enhancing robot therapy to induce motor control improvement in childhood onset primary dystonia.

PubMed

Casellato, Claudia; Pedrocchi, Alessandra; Zorzi, Giovanna; Rizzi, Giorgio; Ferrigno, Giancarlo; Nardocci, Nardo

2012-07-23

Robot-generated deviating forces during multijoint reaching movements have been applied to investigate motor control and to tune neuromotor adaptation. Can the application of force to limbs improve motor learning? In this framework, the response to altered dynamic environments of children affected by primary dystonia has never been studied. As preliminary pilot study, eleven children with primary dystonia and eleven age-matched healthy control subjects were asked to perform upper limb movements, triangle-reaching (three directions) and circle-writing, using a haptic robot interacting with ad-hoc developed task-specific visual interfaces. Three dynamic conditions were provided, null additive external force (A), constant disturbing force (B) and deactivation of the additive external force again (C). The path length for each trial was computed, from the recorded position data and interaction events. The results show that the disturbing force affects significantly the movement outcomes in healthy but not in dystonic subjects, already compromised in the reference condition: the external alteration uncalibrates the healthy sensorimotor system, while the dystonic one is already strongly uncalibrated. The lack of systematic compensation for perturbation effects during B condition is reflected into the absence of after-effects in C condition, which would be the evidence that CNS generates a prediction of the perturbing forces using an internal model of the environment.The most promising finding is that in dystonic population the altered dynamic exposure seems to induce a subsequent improvement, i.e. a beneficial after-effect in terms of optimal path control, compared with the correspondent reference movement outcome. The short-time error-enhancing training in dystonia could represent an effective approach for motor performance improvement, since the exposure to controlled dynamic alterations induces a refining of the existing but strongly imprecise motor scheme and sensorimotor patterns.

Error-enhancing robot therapy to induce motor control improvement in childhood onset primary dystonia

PubMed Central

2012-01-01

Background Robot-generated deviating forces during multijoint reaching movements have been applied to investigate motor control and to tune neuromotor adaptation. Can the application of force to limbs improve motor learning? In this framework, the response to altered dynamic environments of children affected by primary dystonia has never been studied. Methods As preliminary pilot study, eleven children with primary dystonia and eleven age-matched healthy control subjects were asked to perform upper limb movements, triangle-reaching (three directions) and circle-writing, using a haptic robot interacting with ad-hoc developed task-specific visual interfaces. Three dynamic conditions were provided, null additive external force (A), constant disturbing force (B) and deactivation of the additive external force again (C). The path length for each trial was computed, from the recorded position data and interaction events. Results The results show that the disturbing force affects significantly the movement outcomes in healthy but not in dystonic subjects, already compromised in the reference condition: the external alteration uncalibrates the healthy sensorimotor system, while the dystonic one is already strongly uncalibrated. The lack of systematic compensation for perturbation effects during B condition is reflected into the absence of after-effects in C condition, which would be the evidence that CNS generates a prediction of the perturbing forces using an internal model of the environment. The most promising finding is that in dystonic population the altered dynamic exposure seems to induce a subsequent improvement, i.e. a beneficial after-effect in terms of optimal path control, compared with the correspondent reference movement outcome. Conclusions The short-time error-enhancing training in dystonia could represent an effective approach for motor performance improvement, since the exposure to controlled dynamic alterations induces a refining of the existing but strongly imprecise motor scheme and sensorimotor patterns. PMID:22824547

Stochasticity in staged models of epidemics: quantifying the dynamics of whooping cough

PubMed Central

Black, Andrew J.; McKane, Alan J.

2010-01-01

Although many stochastic models can accurately capture the qualitative epidemic patterns of many childhood diseases, there is still considerable discussion concerning the basic mechanisms generating these patterns; much of this stems from the use of deterministic models to try to understand stochastic simulations. We argue that a systematic method of analysing models of the spread of childhood diseases is required in order to consistently separate out the effects of demographic stochasticity, external forcing and modelling choices. Such a technique is provided by formulating the models as master equations and using the van Kampen system-size expansion to provide analytical expressions for quantities of interest. We apply this method to the susceptible–exposed–infected–recovered (SEIR) model with distributed exposed and infectious periods and calculate the form that stochastic oscillations take on in terms of the model parameters. With the use of a suitable approximation, we apply the formalism to analyse a model of whooping cough which includes seasonal forcing. This allows us to more accurately interpret the results of simulations and to make a more quantitative assessment of the predictions of the model. We show that the observed dynamics are a result of a macroscopic limit cycle induced by the external forcing and resonant stochastic oscillations about this cycle. PMID:20164086

A numerical study of natural convection in a vertical annulus filled with gallium in the presence of magnetic field

NASA Astrophysics Data System (ADS)

Afrand, Masoud; Toghraie, Davood; Karimipour, Arash; Wongwises, Somchai

2017-05-01

Presets work aims to investigate the natural convection inside a cylindrical annulus mold containing molten gallium under a horizontal magnetic field in three-dimensional coordinates. The modeling system is a vertical cylindrical annulus which is made by two co-axial cylinders of internal and external radii. The internal and external walls are maintained isothermal but in different temperatures. The upper and lower sides of annulus are also considered adiabatic while it is filled by an electrical conducting fluid. Three dimensional cylindrical coordinates as (r , θ , z) are used to respond the velocity components as (u , v , w) . The governing equations are steady, laminar and Newtonian using the Boussinesq approximation. Equations are nonlinear and they must be corresponded by applying the finite volume approach; so that the hybrid-scheme is applied to discretize equations. The results imply that magnetic field existence leads to generate the Lorentz force in opposite direction of the buoyancy forces. Moreover the Lorentz force and its corresponded electric field are more significant in both Hartmann layer and Roberts layer, respectively. The strong magnetic field is required to achieve better quality products in the casting process of a liquid metal with a higher Prandtl number.

Joint kinetic determinants of starting block performance in athletic sprinting.

PubMed

Brazil, Adam; Exell, Timothy; Wilson, Cassie; Willwacher, Steffen; Bezodis, Ian N; Irwin, Gareth

2018-07-01

The aim of this study was to explore the relationships between lower limb joint kinetics, external force production and starting block performance (normalised average horizontal power, NAHP). Seventeen male sprinters (100 m PB, 10.67 ± 0.32 s) performed maximal block starts from instrumented starting blocks (1000 Hz) whilst 3D kinematics (250 Hz) were also recorded during the block phase. Ankle, knee and hip resultant joint moment and power were calculated at the rear and front leg using inverse dynamics. Average horizontal force applied to the front (r = 0.46) and rear (r = 0.44) block explained 86% of the variance in NAHP. At the joint level, many "very likely" to "almost certain" relationships (r = 0.57 to 0.83) were found between joint kinetic data and the magnitude of horizontal force applied to each block although stepwise multiple regression revealed that 55% of the variance in NAHP was accounted for by rear ankle moment, front hip moment and front knee power. The current study provides novel insight into starting block performance and the relationships between lower limb joint kinetic and external kinetic data that can help inform physical and technical training practices for this skill.

Detecting the gravitational sensitivity of Paramecium caudatum using magnetic forces

NASA Astrophysics Data System (ADS)

Guevorkian, Karine; Valles, James M., Jr.

2006-03-01

Under normal conditions, Paramecium cells regulate their swimming speed in response to the pN level mechanical force of gravity. This regulation, known as gravikinesis, is more pronounced when the external force is increased by methods such as centrifugation. Here we present a novel technique that simulates gravity fields using the interactions between strong inhomogeneous magnetic fields and cells. We are able to achieve variable gravities spanning from 10xg to -8xg; where g is earth's gravity. Our experiments show that the swimming speed regulation of Paramecium caudatum to magnetically simulated gravity is a true physiological response. In addition, they reveal a maximum propulsion force for paramecia. This advance establishes a general technique for applying continuously variable forces to cells or cell populations suitable for exploring their force transduction mechanisms.

A dynamic load estimation method for nonlinear structures with unscented Kalman filter

NASA Astrophysics Data System (ADS)

Guo, L. N.; Ding, Y.; Wang, Z.; Xu, G. S.; Wu, B.

2018-02-01

A force estimation method is proposed for hysteretic nonlinear structures. The equation of motion for the nonlinear structure is represented in state space and the state variable is augmented by the unknown the time history of external force. Unscented Kalman filter (UKF) is improved for the force identification in state space considering the ill-condition characteristic in the computation of square roots for the covariance matrix. The proposed method is firstly validated by a numerical simulation study of a 3-storey nonlinear hysteretic frame excited by periodic force. Each storey is supposed to follow a nonlinear hysteretic model. The external force is identified and the measurement noise is considered in this case. Then a case of a seismically isolated building subjected to earthquake excitation and impact force is studied. The isolation layer performs nonlinearly during the earthquake excitation. Impact force between the seismically isolated structure and the retaining wall is estimated with the proposed method. Uncertainties such as measurement noise, model error in storey stiffness and unexpected environmental disturbances are considered. A real-time substructure testing of an isolated structure is conducted to verify the proposed method. In the experimental study, the linear main structure is taken as numerical substructure while the one of the isolations with additional mass is taken as the nonlinear physical substructure. The force applied by the actuator on the physical substructure is identified and compared with the measured value from the force transducer. The method proposed in this paper is also validated by shaking table test of a seismically isolated steel frame. The acceleration of the ground motion as the unknowns is identified by the proposed method. Results from both numerical simulation and experimental studies indicate that the UKF based force identification method can be used to identify external excitations effectively for the nonlinear structure with accurate results even with measurement noise, model error and environmental disturbances.

Universal bound on the efficiency of molecular motors

NASA Astrophysics Data System (ADS)

Pietzonka, Patrick; Barato, Andre C.; Seifert, Udo

2016-12-01

The thermodynamic uncertainty relation provides an inequality relating any mean current, the associated dispersion and the entropy production rate for arbitrary non-equilibrium steady states. Applying it here to a general model of a molecular motor running against an external force or torque, we show that the thermodynamic efficiency of such motors is universally bounded by an expression involving only experimentally accessible quantities. For motors pulling cargo through a viscous fluid, a universal bound for the corresponding Stokes efficiency follows as a variant. A similar result holds if mechanical force is used to synthesize molecules of high chemical potential. Crucially, no knowledge of the detailed underlying mechano-chemical mechanism is required for applying these bounds.

Numerical Simulations of Plasma Based Flow Control Applications

NASA Technical Reports Server (NTRS)

Suzen, Y. B.; Huang, P. G.; Jacob, J. D.; Ashpis, D. E.

2005-01-01

A mathematical model was developed to simulate flow control applications using plasma actuators. The effects of the plasma actuators on the external flow are incorporated into Navier Stokes computations as a body force vector. In order to compute this body force vector, the model solves two additional equations: one for the electric field due to the applied AC voltage at the electrodes and the other for the charge density representing the ionized air. The model is calibrated against an experiment having plasma-driven flow in a quiescent environment and is then applied to simulate a low pressure turbine flow with large flow separation. The effects of the plasma actuator on control of flow separation are demonstrated numerically.

Simulated decadal modes of the NH atmospheric circulation arising from intra-decadal variability, external forcing and slow-decadal climate processes

NASA Astrophysics Data System (ADS)

Lou, Jiale; Zheng, Xiaogu; Frederiksen, Carsten S.; Liu, Haibo; Grainger, Simon; Ying, Kairan

2017-04-01

A decadal variance decomposition method is applied to the Northern Hemisphere (NH) 500-hPa geopotential height (GPH) and the sea level pressure (SLP) taken from the last millennium (850-1850 AD) experiment with the coupled climate model CCSM4, to estimate the contribution of the intra-decadal variability to the inter-decadal variability. By removing the intra-decadal variability from the total inter-decadal variability, the residual variability is more likely to be associated with slowly varying external forcings and slow-decadal climate processes, and therefore is referred to as slow-decadal variability. The results show that the (multi-)decadal changes of the NH 500-hPa GPH are primarily dominated by slow-decadal variability, whereas the NH SLP field is primarily dominated by the intra-decadal variability. At both pressure levels, the leading intra-decadal modes each have features related to the El Niño-southern oscillation, the intra-decadal variability of the Pacific decadal oscillation (PDO) and the Arctic oscillation (AO); while the leading slow-decadal modes are associated with external radiative forcing (mostly with volcanic aerosol loadings), the Atlantic multi-decadal oscillation and the slow-decadal variability of AO and PDO. Moreover, the radiative forcing has much weaker effect to the SLP than that to the 500-hPa GPH.

Validation of a dynamic linked segment model to calculate joint moments in lifting.

PubMed

de Looze, M P; Kingma, I; Bussmann, J B; Toussaint, H M

1992-08-01

A two-dimensional dynamic linked segment model was constructed and applied to a lifting activity. Reactive forces and moments were calculated by an instantaneous approach involving the application of Newtonian mechanics to individual adjacent rigid segments in succession. The analysis started once at the feet and once at a hands/load segment. The model was validated by comparing predicted external forces and moments at the feet or at a hands/load segment to actual values, which were simultaneously measured (ground reaction force at the feet) or assumed to be zero (external moments at feet and hands/load and external forces, beside gravitation, at hands/load). In addition, results of both procedures, in terms of joint moments, including the moment at the intervertebral disc between the fifth lumbar and first sacral vertebra (L5-S1), were compared. A correlation of r = 0.88 between calculated and measured vertical ground reaction forces was found. The calculated external forces and moments at the hands showed only minor deviations from the expected zero level. The moments at L5-S1, calculated starting from feet compared to starting from hands/load, yielded a coefficient of correlation of r = 0.99. However, moments calculated from hands/load were 3.6% (averaged values) and 10.9% (peak values) higher. This difference is assumed to be due mainly to erroneous estimations of the positions of centres of gravity and joint rotation centres. The estimation of the location of L5-S1 rotation axis can affect the results significantly. Despite the numerous studies estimating the load on the low back during lifting on the basis of linked segment models, only a few attempts to validate these models have been made. This study is concerned with the validity of the presented linked segment model. The results support the model's validity. Effects of several sources of error threatening the validity are discussed. Copyright © 1992. Published by Elsevier Ltd.

Characterization of Akiyama probe applied to dual-probes atomic force microscope

NASA Astrophysics Data System (ADS)

Wang, Hequn; Gao, Sitian; Li, Wei; Shi, Yushu; Li, Qi; Li, Shi; Zhu, Zhendong

2016-10-01

The measurement of nano-scale line-width has always been important and difficult in the field of nanometer measurements, while the rapid development of integrated circuit greatly raises the demand again. As one kind of scanning probe microscope (SPM), atomic force microscope (AFM) can realize quasi three-dimensional measurement, which is widely used in nanometer scale line-width measurement. Our team researched a dual-probes atomic force microscope, which can eliminate the prevalent effect of probe width on measurement results. In dual-probes AFM system, a novel head are newly designed. A kind of self-sensing and self-exciting probes which is Nanosensors cooperation's patented probe—Akiyama probe, is used in this novel head. The Akiyama probe applied to dual-probe atomic force microscope is one of the most important issues. The characterization of Akiyama probe would affect performance and accuracy of the whole system. The fundamental features of the Akiyama probe are electrically and optically characterized in "approach-withdraw" experiments. Further investigations include the frequency response of an Akiyama probe to small mechanical vibrations externally applied to the tip and the effective loading force yielding between the tip and the sample during the periodic contact. We hope that the characterization of the Akiyama probe described in this paper will guide application for dual-probe atomic force microscope.

Mathematical model for gyroscope effects

NASA Astrophysics Data System (ADS)

Usubamatov, Ryspek

2015-05-01

Gyroscope effects are used in many engineering calculations of rotating parts, and a gyroscope is the basic unit of numerous devices and instruments used in aviation, space, marine and other industries. The primary attribute of a gyroscope is a spinning rotor that persists in maintaining its plane of rotation, creating gyroscope effects. Numerous publications represent the gyroscope theory using mathematical models based on the law of kinetic energy conservation and the rate of change in angular momentum of a spinning rotor. Gyroscope theory still attracts many researchers who continue to discover new properties of gyroscopic devices. In reality, gyroscope effects are more complex and known mathematical models do not accurately reflect the actual motions. Analysis of forces acting on a gyroscope shows that four dynamic components act simultaneously: the centrifugal, inertial and Coriolis forces and the rate of change in angular momentum of the spinning rotor. The spinning rotor generates a rotating plane of centrifugal and Coriols forces that resist the twisting of the spinning rotor with external torque applied. The forced inclination of the spinning rotor generates inertial forces, resulting in precession torque of a gyroscope. The rate of change of the angular momentum creates resisting and precession torques which are not primary one in gyroscope effects. The new mathematical model for the gyroscope motions under the action of the external torque applied can be as base for new gyroscope theory. At the request of the author of the paper, this corrigendum was issued on 24 May 2016 to correct an incomplete Table 1 and errors in Eq. (47) and Eq. (48).

The force applied to successfully turn a foetus during reattempts of external cephalic version is substantially reduced when performed under spinal analgesia.

PubMed

Suen, Stephen Sik Hung; Khaw, Kim S; Law, Lai Wa; Sahota, Daljit Singh; Lee, Shara Wee Yee; Lau, Tze Kin; Leung, Tak Yeung

2012-06-01

To compare the forces exerted during external cephalic version (ECV) on the maternal abdomen between ( 1 ) the primary attempts performed without spinal analgesia (SA), which failed and ( 2 ) the subsequent reattempts performed under SA. Patients with an uncomplicated singleton breech-presenting pregnancy suitable for ECV were recruited. During ECV, the operator wore a pair of gloves, which had thin piezo-resistive pressure sensors measuring the contact pressure between the operator's hands and maternal abdomen. For patients who had failed ECV, reattempts by the same operator was made with patients under SA, and the applied force was measured in the same manner. The profile of the exerted forces over time during each attempt was analyzed and denoted by pressure-time integral (PTI: mmHg sec). Pain score was also graded by patients using visual analogue scale. Both PTI and pain score before and after the use of SA were then compared. Overall, eight patients who had a failed ECV without SA underwent a reattempt with SA. All of them had successful version and the median PTI of the successful attempts under SA were lower than that of the previous failed attempts performed without SA (127 386 mmHg sec vs. 298,424 mmHg sec; p = 0.017). All of them also reported a 0 pain score, which was significantly lower than that of before (median 7.5; p = 0.016). SA improves the success rate of ECV as well as reduces the force required for successful version.

Entropic stochastic resonance without external force in oscillatory confined space.

PubMed

Ding, Huai; Jiang, Huijun; Hou, Zhonghuai

2015-05-21

We have studied the dynamics of Brownian particles in a confined geometry of dumbbell-shape with periodically oscillating walls. Entropic stochastic resonance (ESR) behavior, characterizing by a maximum value of the coherent factor Q at some optimal level of noise, is observed even without external periodic force in the horizontal direction, which is necessary for conventional ESR where the wall is static and the particle is subjected to the force. Interestingly, the ESR can be remarkably enhanced by the particle gravity G, in contrast to the conventional case. In addition, Q decreases (increases) with G in the small (large) noise limit, respectively, while it non-monotonically changes with G for moderate noise levels. We have applied an effective 1D coarsening description to illustrate such a nontrivial dependence on G, by investigating the property of the 1D effective potential of entropic nature and paying special attention to the excess part resulting from the boundary oscillation. Dependences of the ESR strength with other related parameters are also discussed.

Breakdown of Amontons' Law of Friction in Sheared-Elastomer with Local Amontons' Friction

NASA Astrophysics Data System (ADS)

Matsukawa, Hiroshi; Otsuki, Michio

2012-02-01

It is well known that Amontons' law of friction i.e. the frictional force against the sliding motion of solid object is proportional to the loading force and not dependent on the contact area, holds well for various systems. Here we show, however, the breakdown of the Amontons' law for the elastic object which have local friction obeying Amontons' law and is under uniform pressure by FEM calculation The external shearing force applied to the trailing edge of the sample induces local slip. The range of the slip increases with the increasing external force adiabatically at first. When the range reaches the critical magnitude, the slips moves rapidly and reaches the leading edge of the sample then the whole system slides. These behaviors are consistent with the experiment by Rubinstein et.al. (Phys. Rev. Lett. 98, 226103). The static frictional coefficient, the ratio between the static frictional force for the whole system and the loading force, decreases with the increasing pressure. This means the breakdown of Amontons' law. The pressure dependence of the frictional coefficient is caused by the change of the critical length of the local slip. The behaviors of the local slip and the frictional coefficient are well explained by the 1 dimensional model analytically.

Magnetic Actuator Modelling for Rotating Machinery Analysis

NASA Astrophysics Data System (ADS)

Mendes, Ricardo Ugliara; de Castro, Hélio Fiori; Cavalca, Kátia Lucchesi; Ferreira, Luiz Otávio Saraiva

Rotating machines have a wide range of application such as airplanes, factories, laboratories and power plants. Lately, with computer aid design, shafts finite element models including bearings, discs, seals and couplings have been developed, allowing the prediction of the machine behavior. In order to keep confidence during operation, it is necessary to monitor these systems, trying to predict future failures. One of the most applied technique for this purpose is the modal analysis. It consists of applying a perturbation force into the system and then to measure its response. However, there is a difficulty that brings limitations to the excitation of systems with rotating shafts when using impact hammers or shakers, once due to friction, undesired tangential forces and noise can be present in the measurements. Therefore, the study of a non-contact technique of external excitation becomes of high interest. In this sense, the present work deals with the study and development of a finite element model for rotating machines using a magnetic actuator as an external excitation source. This work also brings numerical simulations where the magnetic actuator was used to obtain the frequency response function of the rotating system.

Asymptotic co- and post-seismic displacements in a homogeneous Maxwell sphere

NASA Astrophysics Data System (ADS)

Tang, He; Sun, Wenke

2018-07-01

The deformations of the Earth caused by internal and external forces are usually expressed through Green's functions or the superposition of normal modes, that is, via numerical methods, which are applicable for computing both co- and post-seismic deformations. It is difficult to express these deformations in an analytical form, even for a uniform viscoelastic sphere. In this study, we present a set of asymptotic solutions for computing co- and post-seismic displacements; these solutions can be further applied to solving co- and post-seismic geoid, gravity and strain changes. Expressions are derived for a uniform Maxwell Earth by combining the reciprocity theorem, which links earthquake, tidal, shear and loading deformations, with the asymptotic solutions of these three external forces (tidal, shear and loading) and analytical inverse Laplace transformation formulae. Since the asymptotic solutions are given in a purely analytical form without series summations or extra convergence skills, they can be practically applied in an efficient way, especially when computing post-seismic deformations and glacial isotactic adjustments of the Earth over long timescales.

Asymptotic Co- and Post-seismic displacements in a homogeneous Maxwell sphere

NASA Astrophysics Data System (ADS)

Tang, He; Sun, Wenke

2018-05-01

The deformations of the Earth caused by internal and external forces are usually expressed through Green's functions or the superposition of normal modes, i.e. via numerical methods, which are applicable for computing both co- and post-seismic deformations. It is difficult to express these deformations in an analytical form, even for a uniform viscoelastic sphere. In this study, we present a set of asymptotic solutions for computing co- and post-seismic displacements; these solutions can be further applied to solving co- and post-seismic geoid, gravity, and strain changes. Expressions are derived for a uniform Maxwell Earth by combining the reciprocity theorem, which links earthquake, tidal, shear and loading deformations, with the asymptotic solutions of these three external forces (tidal, shear and loading) and analytical inverse Laplace transformation formulae. Since the asymptotic solutions are given in a purely analytical form without series summations or extra convergence skills, they can be practically applied in an efficient way, especially when computing post-seismic deformations and glacial isotactic adjustments of the Earth over long timescales.

An Experimental Design of Bypass Magneto-Rheological (MR) damper

NASA Astrophysics Data System (ADS)

Rashid, MM; Aziz, Mohammad Abdul; Raisuddin Khan, Md.

2017-11-01

The magnetorheological (MR) fluid bypass damper fluid flow through a bypass by utilizing an external channel which allows the controllability of MR fluid in the channel. The Bypass MR damper (BMRD) contains a rectangular bypass flow channel, current controlled movable piston shaft arrangement and MR fluid. The static piston coil case is winding by a coil which is used inside the piston head arrangement. The current controlled coil case provides a magnetic flux through the BMRD cylinder for controllability. The high strength of alloy steel materials are used for making piston shaft which allows magnetic flux propagation throughout the BMRD cylinder. Using the above design materials, a Bypass MR damper is designed and tested. An excitation of current is applied during the experiment which characterizes the BMRD controllability. It is shown that the BMRD with external flow channel allows a high controllable damping force using an excitation current. The experimental result of damping force-displacement characteristics with current excitation and without current excitation are compared in this research. The BMRD model is validated by the experimental result at various frequencies and applied excitation current.

Effect of External Loading on Force and Power Production During Plyometric Push-ups.

PubMed

Hinshaw, Taylour J; Stephenson, Mitchell L; Sha, Zhanxin; Dai, Boyi

2018-04-01

Hinshaw, TJ, Stephenson, ML, Sha, Z, and Dai, B. Effect of external loading on force and power production during plyometric push-ups. J Strength Cond Res 32(4): 1099-1108, 2018-One common exercise to train upper-body strength and power is the push-up. Training at the loads that would produce the greatest power is an effective way to increase peak power. The purpose of the current study was to quantify the changes in peak force, peak power, and peak velocity among a modified plyometric push-up and plyometric push-ups with or without external loading in physically active young adults. Eighteen male and 17 female participants completed 4 push-ups: (a) modified plyometric push-up on the knees, (b) plyometric push-up without external loading, (c) plyometric push-up with an external load of 5% of body weight, and (d) plyometric push-up with an external load of 10% of body weight. Two force platforms were set up to collect vertical ground reaction forces at the hands and feet. The modified plyometric push-up demonstrated the lowest force, power, and velocity (5.4≥ Cohen's dz ≥1.2). Peak force and force at peak velocity increased (3.8≥ Cohen's dz ≥0.3) and peak velocity and velocity at peak power decreased (1.4≥ Cohen's dz ≥0.8) for the push-up without external loading compared with the 2 push-ups with external loading. No significant differences were observed for peak power among the push-ups with or without external loading (0.4≥ Cohen's dz ≥0.1). Although peak power is similar with or without external loading, push-ups without external loading may be more beneficial for a quick movement, and push-ups with external loading may be more beneficial for a greater force production.

Grabbing the Air Force by the Tail: Applying Strategic Cost Analytics to Understand and Manage Indirect Cost Behavior

DTIC Science & Technology

2015-09-17

impact influenced by its internal and external supply chain activities. This starts with understanding how we currently apply advanced analytic techniques... minimalistic model provides for sufficient degrees of freedom to guard against overfitting. Second, to guard against the possibility of an over-trained model in... starting with 1*. 201* All Military compensation EEICs starting with 201*. Facility Sustainment 52* & 56* All facility maintenance, repair and minor

Design of Interactively Time-Pulsed Microfluidic Mixers in Microchips using Numerical Simulation

NASA Astrophysics Data System (ADS)

Fu, Lung-Ming; Tsai, Chien-Hsiung

2007-01-01

In this paper, we propose a novel technique in which driving voltages are applied interactively to the respective inlet fluid flows of three configurations of a microfluidic device, namely T-shaped, double-T-shaped, and double-cross-shaped configurations, to induce electroosmotic flow (EOF) velocity variations in such a way as to develop a rapid mixing effect in the microchannel. In these configurations a microfluidic mixer apply only one electrokinetic driving force, which drives the sample fluids and simultaneously produces a periodic switching frequency. It requires no other external driving force to induce perturbations to the flow field. The effects of the main applied electric field, the interactive frequency, and the pullback electric field on the mixing performance are thoroughly examined numerically. The optimal interactive frequency range for a given set of micromixer parameters is identified for each type of control mode. The numerical results confirm that micromixers operating at an optimal interactive frequency are capable of delivering a significantly enhanced mixing performance. Furthermore, it is shown that the optimal interactive frequency depends upon the magnitude of the main applied electric field. The interactively pulsed mixers developed in this study have a strong potential for use in lab-on-a-chip systems. They involve a simpler fabrication process than either passive or active on-chip mixers and require less human intervention in operation than their bulky external counterparts.

Multidigit force control during unconstrained grasping in response to object perturbations

PubMed Central

Haschke, Robert; Ritter, Helge; Santello, Marco; Ernst, Marc O.

2017-01-01

Because of the complex anatomy of the human hand, in the absence of external constraints, a large number of postures and force combinations can be used to attain a stable grasp. Motor synergies provide a viable strategy to solve this problem of motor redundancy. In this study, we exploited the technical advantages of an innovative sensorized object to study unconstrained hand grasping within the theoretical framework of motor synergies. Participants were required to grasp, lift, and hold the sensorized object. During the holding phase, we repetitively applied external disturbance forces and torques and recorded the spatiotemporal distribution of grip forces produced by each digit. We found that the time to reach the maximum grip force during each perturbation was roughly equal across fingers, consistent with a synchronous, synergistic stiffening across digits. We further evaluated this hypothesis by comparing the force distribution of human grasping vs. robotic grasping, where the control strategy was set by the experimenter. We controlled the global hand stiffness of the robotic hand and found that this control algorithm produced a force pattern qualitatively similar to human grasping performance. Our results suggest that the nervous system uses a default whole hand synergistic control to maintain a stable grasp regardless of the number of digits involved in the task, their position on the objects, and the type and frequency of external perturbations. NEW & NOTEWORTHY We studied hand grasping using a sensorized object allowing unconstrained finger placement. During object perturbation, the time to reach the peak force was roughly equal across fingers, consistently with a synergistic stiffening across fingers. Force distribution of a robotic grasping hand, where the control algorithm is based on global hand stiffness, was qualitatively similar to human grasping. This suggests that the central nervous system uses a default whole hand synergistic control to maintain a stable grasp. PMID:28228582

Tunable electronic and magnetic properties of two-dimensional materials and their one-dimensional derivatives.

PubMed

Zhang, Zhuhua; Liu, Xiaofei; Yu, Jin; Hang, Yang; Li, Yao; Guo, Yufeng; Xu, Ying; Sun, Xu; Zhou, Jianxin; Guo, Wanlin

2016-01-01

Low-dimensional materials exhibit many exceptional properties and functionalities which can be efficiently tuned by externally applied force or fields. Here we review the current status of research on tuning the electronic and magnetic properties of low-dimensional carbon, boron nitride, metal-dichalcogenides, phosphorene nanomaterials by applied engineering strain, external electric field and interaction with substrates, etc, with particular focus on the progress of computational methods and studies. We highlight the similarities and differences of the property modulation among one- and two-dimensional nanomaterials. Recent breakthroughs in experimental demonstration of the tunable functionalities in typical nanostructures are also presented. Finally, prospective and challenges for applying the tunable properties into functional devices are discussed. WIREs Comput Mol Sci 2016, 6:324-350. doi: 10.1002/wcms.1251 For further resources related to this article, please visit the WIREs website. The authors have declared no conflicts of interest for this article.

Magneto-motive detection of tissue-based macrophages by differential phase optical coherence tomography.

PubMed

Oh, Junghwan; Feldman, Marc D; Kim, Jihoon; Kang, Hyun Wook; Sanghi, Pramod; Milner, Thomas E

2007-03-01

A novel method to detect tissue-based macrophages using a combination of superparamagnetic iron oxide (SPIO) nanoparticles and differential phase optical coherence tomography (DP-OCT) with an external oscillating magnetic field is reported. Magnetic force acting on iron-laden tissue-based macrophages was varied by applying a sinusoidal current to a solenoid containing a conical iron core that substantially focused and increased magnetic flux density. Nanoparticle motion was detected with DP-OCT, which can detect tissue movement with nanometer resolution. Frequency response of iron-laden tissue movement was twice the modulation frequency since the magnetic force is proportional to the product of magnetic flux density and gradient. Results of our experiments indicate that DP-OCT can be used to identify tissue-based macrophage when excited by an external focused oscillating magnetic field. (c) 2007 Wiley-Liss, Inc

Maintaining rotational equilibrium during object manipulation: linear behavior of a highly non-linear system

PubMed Central

Gao, Fan; Latash, Mark L.

2010-01-01

We address issues of simultaneous control of the grasping force and the total moment of forces applied to a handheld object during its manipulation. Six young healthy male subjects grasped an instrumented handle and performed its cyclic motion in the vertical direction. The handle allowed for setting different clockwise (negative) or counterclockwise torques. Three movement frequencies: 1, 1.5 and 2 Hz, and five different torques: −1/3, −1/6, 0, 1/6 and 1/3 Nm, were used. The rotational equilibrium was maintained by two means: (1) Concerted changes of the moments produced by the normal and tangential forces, specifically anti-phase changes of the moments during the tasks with zero external torque and in-phase changes during the non-zero-torque tasks, and (2) Redistribution of the normal forces among individual fingers such that the agonist fingers—the fingers that resist external torque—increased the force in phase with the acceleration, while the forces of the antagonist fingers—those that assist the external torque—especially, the fingers with the large moment arms, the index and little fingers, stayed unchanged. The observed effects agree with the principle of superposition—according to which some complex actions, for example, prehension, can be decomposed into elemental actions controlled independently—and the mechanical advantage hypothesis according to which in moment production the fingers are activated in proportion to their moment arms with respect to the axis of rotation. We would like to emphasize the linearity of the observed relations, which was not prescribed by the task mechanics and seems to be produced by specific neural control mechanisms. PMID:16328302

Magnetic fields applied to collagen-coated ferric oxide beads induce stretch-activated Ca2+ flux in fibroblasts.

PubMed

Glogauer, M; Ferrier, J; McCulloch, C A

1995-11-01

The ability to apply controlled forces to the cell membrane may enable elucidation of the mechanisms and pathways involved in signal transduction in response to applied physical stimuli. We have developed a magnetic particle-electromagnet model that allows the application of controlled forces to the plasma membrane of substrate-attached fibroblasts. The system allows applied forces to be controlled by the magnitude of the magnetic field and by the surface area of cell membrane covered with collagen-coated ferric beads. Analysis by single-cell ratio fluorimetry of fura 2-loaded cells demonstrated large calcium transients (50-300 nM) in response to the magnetic force applications. Experiments using either the stretch-activated channel blocker gadolinium chloride or ethylene glycol-bis(beta-aminoethyl ether)-N,N,N',N'-tetraacetic acid to eliminate external calcium ions, or addition of extracellular manganese ions, indicated that there was a calcium influx through putative stretch-activated channels. The probability of a calcium influx in single cells was increased by higher surface bead loading and the degree of cell spreading. Depolymerization of actin filaments by cytochalasin D increased the amplitude of calcium response twofold. The regulation of calcium flux by filamentous actin content and by cell spreading indicates a possible modulatory role for the cytoskeleton in channel sensitivity. Magnetic force application to beads on single cells provides a controlled model to study mechanisms and heterogeneity in physical force stimulation of cation-permeable channels.

Macroscopic model of scanning force microscope

DOEpatents

Guerra-Vela, Claudio; Zypman, Fredy R.

2004-10-05

A macroscopic version of the Scanning Force Microscope is described. It consists of a cantilever under the influence of external forces, which mimic the tip-sample interactions. The use of this piece of equipment is threefold. First, it serves as direct way to understand the parts and functions of the Scanning Force Microscope, and thus it is effectively used as an instructional tool. Second, due to its large size, it allows for simple measurements of applied forces and parameters that define the state of motion of the system. This information, in turn, serves to compare the interaction forces with the reconstructed ones, which cannot be done directly with the standard microscopic set up. Third, it provides a kinematics method to non-destructively measure elastic constants of materials, such as Young's and shear modules, with special application for brittle materials.

Continuum Reconfigurable Parallel Robots for Surgery: Shape Sensing and State Estimation with Uncertainty.

PubMed

Anderson, Patrick L; Mahoney, Arthur W; Webster, Robert J

2017-07-01

This paper examines shape sensing for a new class of surgical robot that consists of parallel flexible structures that can be reconfigured inside the human body. Known as CRISP robots, these devices provide access to the human body through needle-sized entry points, yet can be configured into truss-like structures capable of dexterous movement and large force application. They can also be reconfigured as needed during a surgical procedure. Since CRISP robots are elastic, they will deform when subjected to external forces or other perturbations. In this paper, we explore how to combine sensor information with mechanics-based models for CRISP robots to estimate their shapes under applied loads. The end result is a shape sensing framework for CRISP robots that will enable future research on control under applied loads, autonomous motion, force sensing, and other robot behaviors.

Deformation of fluctuating chiral ribbons

NASA Astrophysics Data System (ADS)

Panyukov, Sergey

2003-03-01

We find analytical solution of the model of a fluctuating filament with a spontaneously twisted noncircular cross section in the presence of external force and torque. We show that when such ribbon is subjected to a sufficiently strong extensional force, it exhibits an asymmetric response to large degrees of overwinding and unwinding. We construct the stability diagram that describes the buckling transition of such ribbons under the opposing action of force and torque and show that all the observed behaviors can be understood in terms of continuous transformations between straight and spiral states of the ribbon. The relation between our results and experimental observations on DNA is discussed and a new reentrant spiral to rod transition is predicted at intermediate values of twist rigidity and applied force.

Effects of Initial Graft Tension on the Tibiofemoral Compressive Forces and Joint Position Following ACL Reconstruction

PubMed Central

Brady, Mark F.; Bradley, Michael P.; Fleming, Braden C.; Fadale, Paul D.; Hulstyn, Michael J.; Banerjee, Rahul

2007-01-01

Background The initial tension applied to an ACL graft at the time of fixation modulates knee motion and the tibiofemoral compressive loads. Purpose To establish the relationships between initial graft tension, tibiofemoral compressive force, and the neutral tibiofemoral position in the cadaver knee. Study Design Controlled Laboratory Study. Methods The tibiofemoral compressive forces and joint positions were determined in the ACL-intact knee at 0°, 20° and 90° knee flexion. The ACL was excised and reconstructed with a patellar tendon graft using graft tensions of 1, 15, 30, 60 and 90 N applied at 0°, 20° and 90° knee flexion. The compressive forces and neutral positions were compared between initial tension conditions and the ACL-intact knee. Results Increasing initial graft tension increased the tibiofemoral compressive forces. The forces in the medial compartment were 1.8 times those in the lateral compartment. The compressive forces were dependent on the knee angle at which the tension was applied. The greatest compressive forces occurred when the graft was tensioned with the knee in extension. An increase in initial graft tension caused the tibia to rotate externally compared to the ACL-intact knee. Increases in initial graft tension also caused a significant posterior translation of the tibia relative to the femur. Conclusions Different initial graft tension protocols produced predictable changes in the tibiofemoral compressive forces and joint positions. Clinical Relevance The tibiofemoral compressive force and neutral joint position were best replicated with a low graft tension (1–15 N) when using a patellar tendon graft. PMID:17218659

Measurement of Distraction Force in Cleft Lip and Palate Patients During Le Fort I Maxillary Advancement With Rigid External Distraction.

PubMed

Sawada, Hiromi; Ogawa, Takuya; Kataoka, Keiichi; Baba, Yoshiyuki; Moriyama, Keiji

2017-03-01

Maxillary distraction osteogenesis (DO) is a mainstream surgical technique for patients who have severe maxillary hypoplasia associated with craniofacial syndromes and cleft-related deformities. However, limited information about the biomechanical aspects of maxillary DO is available limiting broad utilization and improvements to the procedure. The objective of this study was to analyze force levels during the active distraction process and to investigate the relationship between distraction force and maxillary movement during Le Fort I maxillary DO using a rigid external distraction (RED) system. Microtension gauges were integrated into the distraction wires on each side of the RED system. Six patients with cleft lip and palate aged 12.8 to 23.5 years underwent strain gauge measurements during maxillary advancement with DO using an RED system. Lateral cephalograms were taken to measure maxillary horizontal, vertical, and linear movements after DO. The average linear maxillary movement was 11.2 mm (range 8.5-15.9 mm). The applied forces ranged from 13.4 to 26.8 N. The distance of maxillary movement was proportional to the distraction force. The measurement of distraction forces during DO provides important information with which to establish appropriate protocols. Patients requiring more advancement may require more distraction force. However, other factors such as scarring, patient anatomy, surgical freedom of the osteotomized maxilla, and the like, may affect the required force during DO with the RED system.

Force-Induced Unravelling of DNA Origami.

PubMed

Engel, Megan C; Smith, David M; Jobst, Markus A; Sajfutdinow, Martin; Liedl, Tim; Romano, Flavio; Rovigatti, Lorenzo; Louis, Ard A; Doye, Jonathan P K

2018-05-31

The mechanical properties of DNA nanostructures are of widespread interest as applications that exploit their stability under constant or intermittent external forces become increasingly common. We explore the force response of DNA origami in comprehensive detail by combining AFM single molecule force spectroscopy experiments with simulations using oxDNA, a coarse-grained model of DNA at the nucleotide level, to study the unravelling of an iconic origami system: the Rothemund tile. We contrast the force-induced melting of the tile with simulations of an origami 10-helix bundle. Finally, we simulate a recently-proposed origami biosensor, whose function takes advantage of origami behaviour under tension. We observe characteristic stick-slip unfolding dynamics in our force-extension curves for both the Rothemund tile and the helix bundle and reasonable agreement with experimentally observed rupture forces for these systems. Our results highlight the effect of design on force response: we observe regular, modular unfolding for the Rothemund tile that contrasts with strain-softening of the 10-helix bundle which leads to catastropic failure under monotonically increasing force. Further, unravelling occurs straightforwardly from the scaffold ends inwards for the Rothemund tile, while the helix bundle unfolds more nonlinearly. The detailed visualization of the yielding events provided by simulation allows preferred pathways through the complex unfolding free-energy landscape to be mapped, as a key factor in determining relative barrier heights is the extensional release per base pair broken. We shed light on two important questions: how stable DNA nanostructures are under external forces; and what design principles can be applied to enhance stability.

Inferring Interaction Force from Visual Information without Using Physical Force Sensors.

PubMed

Hwang, Wonjun; Lim, Soo-Chul

2017-10-26

In this paper, we present an interaction force estimation method that uses visual information rather than that of a force sensor. Specifically, we propose a novel deep learning-based method utilizing only sequential images for estimating the interaction force against a target object, where the shape of the object is changed by an external force. The force applied to the target can be estimated by means of the visual shape changes. However, the shape differences in the images are not very clear. To address this problem, we formulate a recurrent neural network-based deep model with fully-connected layers, which models complex temporal dynamics from the visual representations. Extensive evaluations show that the proposed learning models successfully estimate the interaction forces using only the corresponding sequential images, in particular in the case of three objects made of different materials, a sponge, a PET bottle, a human arm, and a tube. The forces predicted by the proposed method are very similar to those measured by force sensors.

Differences in knee joint kinematics and forces after posterior cruciate retaining and stabilized total knee arthroplasty.

PubMed

Wünschel, Markus; Leasure, Jeremi M; Dalheimer, Philipp; Kraft, Nicole; Wülker, Nikolaus; Müller, Otto

2013-12-01

Posterior cruciate ligament (PCL) retaining (CR) and -sacrificing (PS) total knee arthroplasties (TKA) are widely-used to treat osteoarthritis of the knee joint. The PS design substitutes the function of the PCL with a cam-spine mechanism which may produce adverse changes to joint kinematics and kinetics. CR- and PS-TKA were performed on 11 human knee specimens. Joint kinematics were measured with a dynamic knee simulator and motion tracking equipment. In-situ loads of the PCL and cam-spine were measured with a robotic force sensor system. Partial weight bearing flexions were simulated and external forces were applied. The PS-TKA rotated significantly less throughout the whole flexion range compared to the CR-TKA. Femoral roll back was greater in the PS-TKA; however, this was not correlated with lower quadriceps forces. Application of external loads produced significantly different in-situ force profiles between the TKA systems. Our data demonstrate that the PS-design significantly alters kinematics of the knee joint. Our data also suggest the cam-spine mechanism may have little influence on high flexion kinematics (such as femoral rollback) with most of the load burden shared by supporting implant and soft-tissue structures. Copyright © 2013 Elsevier B.V. All rights reserved.

Using an electrohydraulic ankle foot orthosis to study modifications in feedforward control during locomotor adaptation to force fields applied in stance

PubMed Central

Noel, Martin; Fortin, Karine; Bouyer, Laurent J

2009-01-01

Background Adapting to external forces during walking has been proposed as a tool to improve locomotion after central nervous system injury. However, sensorimotor integration during walking varies according to the timing in the gait cycle, suggesting that adaptation may also depend on gait phases. In this study, an ElectroHydraulic AFO (EHO) was used to apply forces specifically during mid-stance and push-off to evaluate if feedforward movement control can be adapted in these 2 gait phases. Methods Eleven healthy subjects walked on a treadmill before (3 min), during (5 min) and after (5 min) exposure to 2 force fields applied by the EHO (mid-stance/push-off; ~10 Nm, towards dorsiflexion). To evaluate modifications in feedforward control, strides with no force field ('catch strides') were unexpectedly inserted during the force field walking period. Results When initially exposed to a mid-stance force field (FF20%), subjects showed a significant increase in ankle dorsiflexion velocity. Catches applied early into the FF20% were similar to baseline (P > 0.99). Subjects gradually adapted by returning ankle velocity to baseline over ~50 strides. Catches applied thereafter showed decreased ankle velocity where the force field was normally applied, indicating the presence of feedforward adaptation. When initially exposed to a push-off force field (FF50%), plantarflexion velocity was reduced in the zone of force field application. No adaptation occurred over the 5 min exposure. Catch strides kinematics remained similar to control at all times, suggesting no feedforward adaptation. As a control, force fields assisting plantarflexion (-3.5 to -9.5 Nm) were applied and increased ankle plantarflexion during push-off, confirming that the lack of kinematic changes during FF50% catch strides were not simply due to a large ankle impedance. Conclusion Together these results show that ankle exoskeletons such as the EHO can be used to study phase-specific adaptive control of the ankle during locomotion. Our data suggest that, for short duration exposure, a feedforward modification in torque output occurs during mid-stance but not during push-off. These findings are important for the design of novel rehabilitation methods, as they suggest that the ability to use resistive force fields for training may depend on targeted gait phases. PMID:19493356

Using an electrohydraulic ankle foot orthosis to study modifications in feedforward control during locomotor adaptation to force fields applied in stance.

PubMed

Noel, Martin; Fortin, Karine; Bouyer, Laurent J

2009-06-03

Adapting to external forces during walking has been proposed as a tool to improve locomotion after central nervous system injury. However, sensorimotor integration during walking varies according to the timing in the gait cycle, suggesting that adaptation may also depend on gait phases. In this study, an ElectroHydraulic AFO (EHO) was used to apply forces specifically during mid-stance and push-off to evaluate if feedforward movement control can be adapted in these 2 gait phases. Eleven healthy subjects walked on a treadmill before (3 min), during (5 min) and after (5 min) exposure to 2 force fields applied by the EHO (mid-stance/push-off; approximately 10 Nm, towards dorsiflexion). To evaluate modifications in feedforward control, strides with no force field ('catch strides') were unexpectedly inserted during the force field walking period. When initially exposed to a mid-stance force field (FF 20%), subjects showed a significant increase in ankle dorsiflexion velocity. Catches applied early into the FF 20% were similar to baseline (P > 0.99). Subjects gradually adapted by returning ankle velocity to baseline over approximately 50 strides. Catches applied thereafter showed decreased ankle velocity where the force field was normally applied, indicating the presence of feedforward adaptation. When initially exposed to a push-off force field (FF 50%), plantarflexion velocity was reduced in the zone of force field application. No adaptation occurred over the 5 min exposure. Catch strides kinematics remained similar to control at all times, suggesting no feedforward adaptation. As a control, force fields assisting plantarflexion (-3.5 to -9.5 Nm) were applied and increased ankle plantarflexion during push-off, confirming that the lack of kinematic changes during FF 50% catch strides were not simply due to a large ankle impedance. Together these results show that ankle exoskeletons such as the EHO can be used to study phase-specific adaptive control of the ankle during locomotion. Our data suggest that, for short duration exposure, a feedforward modification in torque output occurs during mid-stance but not during push-off. These findings are important for the design of novel rehabilitation methods, as they suggest that the ability to use resistive force fields for training may depend on targeted gait phases.

Deformation of a helical filament by flow and electric or magnetic fields

NASA Astrophysics Data System (ADS)

Kim, Munju; Powers, Thomas R.

2005-02-01

Motivated by recent advances in the real-time imaging of fluorescent flagellar filaments in living bacteria [Turner, Ryu, and Berg, J. Bacteriol. 82, 2793 (2000)], we compute the deformation of a helical elastic filament due to flow and external magnetic or high-frequency electric fields. Two cases of deformation due to hydrodynamic drag are considered: the compression of a filament rotated by a stationary motor and the extension of a stationary filament due to flow along the helical axis. We use Kirchhoff rod theory for the filament, and work to linear order in the deflection. Hydrodynamic forces are described first by resistive-force theory, and then for comparison by the more accurate slender-body theory. For helices with a short pitch, the deflection in axial flow predicted by slender-body theory is significantly smaller than that computed with resistive-force theory. Therefore, our estimate of the bending stiffness of a flagellar filament is smaller than that of previous workers. In our calculation of the deformation of a polarizable helix in an external field, we show that the problem is equivalent to the classical case of a helix deformed by forces applied only at the ends.

Impact of external forcing on simulated hydroclimate from interannual to multicentennial timescales

NASA Astrophysics Data System (ADS)

Roldán, Pedro; Fidel González-Rouco, Jesús; Melo-Aguilar, Camilo

2017-04-01

During the last millennium, external forcing experienced important changes in different timescales. It has been demostrated that these changes had an impact on climate. In particular, changes in solar activity, volcanic eruptions and emissions of greenhouse gases are related to short-term and long-term changes in global temperatures, with situations of higher total external forcing generally related with higher global and hemispherical temperatures, and conversely with situations of lower forcing. This connection is clearly observed in climate simulations from different models and in proxy-based reconstructions. The changes in external forcing can also explain certain changes in atmospheric dynamics and hydroclimate, although in this case it is in general more difficult to trace causality arguments. Analyses based on simulations from two different models (ECHO-G and CESM-LME) have been performed, to assess the impact of external forcing on climate in timescales ranging from interannual to multicentennial. Various climatic variables have been analysed, including temperature, sea level pressure, surface wind, precipitation and soil moisture. For interannual timescales, composites have been defined with the years before and after the main volcanic eruptions of the last millennium as well as the minima of solar activity during this period. For longer timescales, a Principal Component analysis has been performed, to try to separate the signal of external forcing from that of internal variability. This has been done for the whole millennium and for the pre-industrial period, to assess the difference between natural and anthropogenic forcing. For multicentennial timescales, composites for the Medieval Climate Anomaly (MCA; ca. 950-1250), the Little Ice Age (LIA; ca. 1450-1850) and the 20th Century have been compared. These three periods were respectively characterised by higher, lower and higher forcing. This allows to assess the contribution of external forcing to the evolution of climate over longer time intervals. These analyses have shown that external forcing is an important factor in the evolution of the simulated hydroclimate of the last millennium. In the short-term, it has been observed that volcanic eruptions and other situations of extreme forcing significantly alter the global precipitation in the subsequent years. In the long-term, variations of external forcing can be related to changes in atmospheric dynamics and in hydroclimate. However, this impact is not homogeneously distributed. There are areas where hydroclimate is mainly influenced by the external forcing and other areas more influenced by internal variability, with spatial decorrelation being higher in precipitation or drought related variables than in temperature. The regional sensitivity to external forcing of hydroclimate is model and, to a lesser degree, simulation dependent.

Secular Orbit Evolution in Systems with a Strong External Perturber—A Simple and Accurate Model

DOE Office of Scientific and Technical Information (OSTI.GOV)

Andrade-Ines, Eduardo; Eggl, Siegfried, E-mail: eandrade.ines@gmail.com, E-mail: siegfried.eggl@jpl.nasa.gov

We present a semi-analytical correction to the seminal solution for the secular motion of a planet’s orbit under gravitational influence of an external perturber derived by Heppenheimer. A comparison between analytical predictions and numerical simulations allows us to determine corrective factors for the secular frequency and forced eccentricity in the coplanar restricted three-body problem. The correction is given in the form of a polynomial function of the system’s parameters that can be applied to first-order forced eccentricity and secular frequency estimates. The resulting secular equations are simple, straight forward to use, and improve the fidelity of Heppenheimers solution well beyond higher-ordermore » models. The quality and convergence of the corrected secular equations are tested for a wide range of parameters and limits of its applicability are given.« less

Analyte detection using an active assay

DOEpatents

Morozov, Victor; Bailey, Charles L.; Evanskey, Melissa R.

2010-11-02

Analytes using an active assay may be detected by introducing an analyte solution containing a plurality of analytes to a lacquered membrane. The lacquered membrane may be a membrane having at least one surface treated with a layer of polymers. The lacquered membrane may be semi-permeable to nonanalytes. The layer of polymers may include cross-linked polymers. A plurality of probe molecules may be arrayed and immobilized on the lacquered membrane. An external force may be applied to the analyte solution to move the analytes towards the lacquered membrane. Movement may cause some or all of the analytes to bind to the lacquered membrane. In cases where probe molecules are presented, some or all of the analytes may bind to probe molecules. The direction of the external force may be reversed to remove unbound or weakly bound analytes. Bound analytes may be detected using known detection types.

Design of responsive materials using topologically interlocked elements

NASA Astrophysics Data System (ADS)

Molotnikov, A.; Gerbrand, R.; Qi, Y.; Simon, G. P.; Estrin, Y.

2015-02-01

In this work we present a novel approach to designing responsive structures by segmentation of monolithic plates into an assembly of topologically interlocked building blocks. The particular example considered is an assembly of interlocking osteomorphic blocks. The results of this study demonstrate that the constraining force, which is required to hold the blocks together, can be viewed as a design parameter that governs the bending stiffness and the load bearing capacity of the segmented structure. In the case where the constraining forces are provided laterally using an external frame, the maximum load the assembly can sustain and its stiffness increase linearly with the magnitude of the lateral load applied. Furthermore, we show that the segmented plate with integrated shape memory wires employed as tensioning cables can act as a smart structure that changes its flexural stiffness and load bearing capacity in response to external stimuli, such as heat generated by the switching on and off an electric current.

Viscoelastic Mapping of Living Cell Interiors

NASA Astrophysics Data System (ADS)

Heinrich, Doris; Sackmann, Erich; Koehler, Jana; Gerisch, Guenther

2004-03-01

We performed spatially resolved mapping of the viscoelastic properties of the cytoplasm of living cell interiors. A magnetic tweezer was applied as a local probe for the investigation of active and passive transport inside the slime mold cells Dictyostelium discoideum. Fluorescence labeled components, i.e. the microtubulins, the endoplasmatic reticulum or the core, allow for the determination of the interaction of the magnetic probes with the cytoplasm. By comparing the trajectories of the magnetic beads in the presence of an external magnetic force and in the absence of an external force, we can measure the viscosity at any given position within the cell. These experiments show that the cytoplasm consists of soft pathways (yield stress less or equal 10 Pa) and hard pathways (yield stress less or equal 500 Pa). Selective actin, myosin II or microtubulin network removal in the living cells allows for the determination of the influence of these cell parts on the viscoelastic properties.

Segmentation and Tracking of Cytoskeletal Filaments Using Open Active Contours

PubMed Central

Smith, Matthew B.; Li, Hongsheng; Shen, Tian; Huang, Xiaolei; Yusuf, Eddy; Vavylonis, Dimitrios

2010-01-01

We use open active contours to quantify cytoskeletal structures imaged by fluorescence microscopy in two and three dimensions. We developed an interactive software tool for segmentation, tracking, and visualization of individual fibers. Open active contours are parametric curves that deform to minimize the sum of an external energy derived from the image and an internal bending and stretching energy. The external energy generates (i) forces that attract the contour toward the central bright line of a filament in the image, and (ii) forces that stretch the active contour toward the ends of bright ridges. Images of simulated semiflexible polymers with known bending and torsional rigidity are analyzed to validate the method. We apply our methods to quantify the conformations and dynamics of actin in two examples: actin filaments imaged by TIRF microscopy in vitro, and actin cables in fission yeast imaged by spinning disk confocal microscopy. PMID:20814909

Patterning in systems driven by nonlocal external forces.

PubMed

Luneville, L; Mallick, K; Pontikis, V; Simeone, D

2016-11-01

This work focuses on systems displaying domain patterns resulting from competing external and internal dynamics. To this end, we introduce a Lyapunov functional capable of describing the steady states of systems subject to external forces, by adding nonlocal terms to the Landau Ginzburg free energy of the system. Thereby, we extend the existing methodology treating long-range order interactions, to the case of external nonlocal forces. By studying the quadratic term of this Lyapunov functional, we compute the phase diagram in the temperature versus external field and we determine all possible modulated phases (domain patterns) as a function of the external forces and the temperature. Finally, we investigate patterning in chemical reactive mixtures and binary mixtures under irradiation, and we show that the last case opens the path toward micro-structural engineering of materials.

Patterning in systems driven by nonlocal external forces

NASA Astrophysics Data System (ADS)

Luneville, L.; Mallick, K.; Pontikis, V.; Simeone, D.

2016-11-01

This work focuses on systems displaying domain patterns resulting from competing external and internal dynamics. To this end, we introduce a Lyapunov functional capable of describing the steady states of systems subject to external forces, by adding nonlocal terms to the Landau Ginzburg free energy of the system. Thereby, we extend the existing methodology treating long-range order interactions, to the case of external nonlocal forces. By studying the quadratic term of this Lyapunov functional, we compute the phase diagram in the temperature versus external field and we determine all possible modulated phases (domain patterns) as a function of the external forces and the temperature. Finally, we investigate patterning in chemical reactive mixtures and binary mixtures under irradiation, and we show that the last case opens the path toward micro-structural engineering of materials.

Bias-dependent local structure of water molecules at an electrochemical interface

NASA Astrophysics Data System (ADS)

Pedroza, Luana; Brandimarte, Pedro; Rocha, Alexandre R.; Fernandez-Serra, Marivi

2015-03-01

Following the need for new - and renewable - sources of energy worldwide, fuel cells using electrocatalysts can be thought of as a viable option. Understanding the local structure of water molecules at the interfaces of the metallic electrodes is a key problem. Notably the system is under an external potential bias, which makes the task of simulating this setup difficult. A first principle description of all components of the system is the most appropriate methodology in order to advance understanding of electrochemical processes. There, the metal is usually charged. To correctly compute the effect of an external bias potential applied to electrodes, we combine density functional theory (DFT) and non-equilibrium Green's functions methods (NEGF), with and without van der Waals interactions. In this work, we apply this methodology to study the electronic properties and forces of one water molecule and water monolayer at the interface of gold electrodes. We find that the water molecule has a different torque direction depending on the sign of the bias applied. We also show that it changes the position of the most stable configuration indicating that the external bias plays an important role in the structural properties of the interface. We acknowledge financial support from FAPESP.

Task-specific stability in muscle activation space during unintentional movements.

PubMed

Falaki, Ali; Towhidkhah, Farzad; Zhou, Tao; Latash, Mark L

2014-11-01

We used robot-generated perturbations applied during position-holding tasks to explore stability of induced unintentional movements in a multidimensional space of muscle activations. Healthy subjects held the handle of a robot against a constant bias force and were instructed not to interfere with hand movements produced by changes in the external force. Transient force changes were applied leading to handle displacement away from the initial position and then back toward the initial position. Intertrial variance in the space of muscle modes (eigenvectors in the muscle activations space) was quantified within two subspaces, corresponding to unchanged handle coordinate and to changes in the handle coordinate. Most variance was confined to the former subspace in each of the three phases of movement, the initial steady state, the intermediate position, and the final steady state. The same result was found when the changes in muscle activation were analyzed between the initial and final steady states. Changes in the dwell time between the perturbation force application and removal led to different final hand locations undershooting the initial position. The magnitude of the undershot scaled with the dwell time, while the structure of variance in the muscle activation space did not depend on the dwell time. We conclude that stability of the hand coordinate is ensured during both intentional and unintentional actions via similar mechanisms. Relative equifinality in the external space after transient perturbations may be associated with varying states in the redundant space of muscle activations. The results fit a hierarchical scheme for the control of voluntary movements with referent configurations and redundant mapping between the levels of the hierarchy.

Effective Swimmer’s Action during the Grab Start Technique

PubMed Central

Mourão, Luis; de Jesus, Karla; Roesler, Hélio; Machado, Leandro J.; Fernandes, Ricardo J.; Vilas-Boas, João Paulo; Vaz, Mário A. P.

2015-01-01

The external forces applied in swimming starts have been often studied, but using direct analysis and simple interpretation data processes. This study aimed to develop a tool for vertical and horizontal force assessment based on the swimmers’ propulsive and structural forces (passive forces due to dead weight) applied during the block phase. Four methodological pathways were followed: the experimented fall of a rigid body, the swimmers’ inertia effect, the development of a mathematical model to describe the outcome of the rigid body fall and its generalization to include the effects of the inertia, and the experimental swimmers’ starting protocol analysed with the inclusion of the developed mathematical tool. The first three methodological steps resulted in the description and computation of the passive force components. At the fourth step, six well-trained swimmers performed three 15 m maximal grab start trials and three-dimensional (3D) kinetic data were obtained using a six degrees of freedom force plate. The passive force contribution to the start performance obtained from the model was subtracted from the experimental force due to the swimmers resulting in the swimmers’ active forces. As expected, the swimmers’ vertical and horizontal active forces accounted for the maximum variability contribution of the experimental forces. It was found that the active force profile for the vertical and horizontal components resembled one another. These findings should be considered in clarifying the active swimmers’ force variability and the respective geometrical profile as indicators to redefine steering strategies. PMID:25978370

Dermal Aged and Fetal Fibroblasts Realign in Response to Mechanical Strain

NASA Technical Reports Server (NTRS)

Sawyer, Christine; Grymes, Rose; Alvarez, Teresa (Technical Monitor)

1994-01-01

Integrins specifically recognize and bind extracellular matrix components, providing physical anchor points and functional setpoints. Focal adhesion complexes, containing integrin and cytoskeletal proteins, are potential mechanoreceptors, poised to distribute applied forces through the cytoskeleton. Pursuing the hypothesis that cells both perceive and respond to external force, we applied a stretch/relaxation regimen to normal human fetal and aged dermal fibroblast monolayers cultured on flexible membranes. The frequency and magnitude of the applied force is precisely controlled by the Flexercell Unit(Trademark). A protocol of stretch (20% elongation of the monolayer) at a frequency of 6 cycles/min caused a progressive change from a randomly distributed pattern of cells to a symmetric, radial distribution with cells aligned parallel to the applied force. We have coined the term 'orienteering' as the process of active alignment of cells in response to applied force. Cytochalasin D was added in graded doses to investigate the role of the actin cytoskeleton in force perception and transmission. A clear dose response was found; at high concentrations orienteering was abolished; and the drug's impact was reversible. The two cell strains used were similar in their alignment behavior and in their responses to cytochalasin D. Orienteering was influenced by cell density, and the cell strains studied differed in this respect. Fetal cells, unlike their aged counterparts, failed to orient at high cell density. In both cell strains, mid-density cultures aligned rapidly and sparse cultures lagged. These results indicate that both cell-cell adhesion and cytoskeleton integrity are critical in mediating the orienteering response. Differences between these two cell strains may relate to their expression of extracellular matrix molecules (fibronectin, collagen type 1) integrins and their relative binding affinities.

Microtechnologies for studying the role of mechanics in axon growth and guidance

PubMed Central

Kilinc, Devrim; Blasiak, Agata; Lee, Gil U.

2015-01-01

The guidance of axons to their proper targets is not only a crucial event in neurodevelopment, but also a potential therapeutic target for neural repair. Axon guidance is mediated by various chemo- and haptotactic cues, as well as the mechanical interactions between the cytoskeleton and the extracellular matrix (ECM). Axonal growth cones, dynamic ends of growing axons, convert external stimuli to biochemical signals, which, in turn, are translated into behavior, e.g., turning or retraction, via cytoskeleton–matrix linkages. Despite the inherent mechanical nature of the problem, the role of mechanics in axon guidance is poorly understood. Recent years has witnessed the application of a range of microtechnologies in neurobiology, from microfluidic circuits to single molecule force spectroscopy. In this mini-review, we describe microtechnologies geared towards dissecting the mechanical aspects of axon guidance, divided into three categories: controlling the growth cone microenvironment, stimulating growth cones with externally applied forces, and measuring forces exerted by the growth cones. A particular emphasis is given to those studies that combine multiple techniques, as dictated by the complexity of the problem. PMID:26283918

Microtechnologies for studying the role of mechanics in axon growth and guidance.

PubMed

Kilinc, Devrim; Blasiak, Agata; Lee, Gil U

2015-01-01

The guidance of axons to their proper targets is not only a crucial event in neurodevelopment, but also a potential therapeutic target for neural repair. Axon guidance is mediated by various chemo- and haptotactic cues, as well as the mechanical interactions between the cytoskeleton and the extracellular matrix (ECM). Axonal growth cones, dynamic ends of growing axons, convert external stimuli to biochemical signals, which, in turn, are translated into behavior, e.g., turning or retraction, via cytoskeleton-matrix linkages. Despite the inherent mechanical nature of the problem, the role of mechanics in axon guidance is poorly understood. Recent years has witnessed the application of a range of microtechnologies in neurobiology, from microfluidic circuits to single molecule force spectroscopy. In this mini-review, we describe microtechnologies geared towards dissecting the mechanical aspects of axon guidance, divided into three categories: controlling the growth cone microenvironment, stimulating growth cones with externally applied forces, and measuring forces exerted by the growth cones. A particular emphasis is given to those studies that combine multiple techniques, as dictated by the complexity of the problem.

Lattice QCD with strong external electric fields.

PubMed

Yamamoto, Arata

2013-03-15

We study particle generation by a strong electric field in lattice QCD. To avoid the sign problem of the Minkowskian electric field, we adopt the "isospin" electric charge. When a strong electric field is applied, the insulating vacuum is broken down and pairs of charged particles are produced by the Schwinger mechanism. The competition against the color confining force is also discussed.

Aluminum reduction cell electrode

DOEpatents

Goodnow, Warren H.; Payne, John R.

1982-01-01

The invention is directed to cathode modules comprised of refractory hard metal materials, such as TiB.sub.2, for an electrolytic cell for the reduction of alumina wherein the modules may be installed and replaced during operation of the cell and wherein the structure of the cathode modules is such that the refractory hard metal materials are not subjected to externally applied forces or rigid constraints.

Mechanical stress as a regulator of cell motility

NASA Astrophysics Data System (ADS)

Putelat, T.; Recho, P.; Truskinovsky, L.

2018-01-01

The motility of a cell can be triggered or inhibited not only by an applied force but also by a mechanically neutral force couple. This type of loading, represented by an applied stress and commonly interpreted as either squeezing or stretching, can originate from extrinsic interaction of a cell with its neighbors. To quantify the effect of applied stresses on cell motility we use an analytically transparent one-dimensional model accounting for active myosin contraction and induced actin turnover. We show that stretching can polarize static cells and initiate cell motility while squeezing can symmetrize and arrest moving cells. We show further that sufficiently strong squeezing can lead to the loss of cell integrity. The overall behavior of the system depends on the two dimensionless parameters characterizing internal driving (chemical activity) and external loading (applied stress). We construct a phase diagram in this parameter space distinguishing between static, motile, and collapsed states. The obtained results are relevant for the mechanical understanding of contact inhibition and the epithelial-to-mesenchymal transition.

Experimental investigation of SDBD plasma actuator driven by AC high voltage with a superimposed positive pulse bias voltage

NASA Astrophysics Data System (ADS)

Qi, Xiao-Hua; Yan, Hui-Jie; Yang, Liang; Hua, Yue; Ren, Chun-Sheng

2017-08-01

In this work, a driven voltage consisting of AC high voltage with a superimposed positive pulse bias voltage ("AC+ Positive pulse bias" voltage) is adopted to study the performance of a surface dielectric barrier discharge plasma actuator under atmospheric conditions. To compare the performance of the actuator driven by single-AC voltage and "AC+ Positive pulse bias" voltage, the actuator-induced thrust force and power consumption are measured as a function of the applied AC voltage, and the measured results indicate that the thrust force can be promoted significantly after superimposing the positive pulse bias voltage. The physical mechanism behind the thrust force changes is analyzed by measuring the optical properties, electrical characteristics, and surface potential distribution. Experimental results indicate that the glow-like discharge in the AC voltage half-cycle, next to the cycle where a bias voltage pulse has been applied, is enhanced after applying the positive pulse bias voltage, and this perhaps is the main reason for the thrust force increase. Moreover, surface potential measurement results reveal that the spatial electric field formed by the surface charge accumulation after positive pulse discharge can significantly affect the applied external electric field, and this perhaps can be responsible for the experimental phenomenon that the decrease of thrust force is delayed by pulse bias voltage action after the filament discharge occurs in the glow-like discharge region. The schlieren images further verify that the actuator-induced airflow velocity increases with the positive pulse voltage.

Native flexibility of structurally homologous proteins: insights from anisotropic network model.

PubMed

Sarkar, Ranja

2017-01-01

Single-molecule microscopic experiments can measure the mechanical response of proteins to pulling forces applied externally along different directions (inducing different residue pairs in the proteins by uniaxial tension). This response to external forces away from equilibrium should in principle, correlate with the flexibility or stiffness of proteins in their folded states. Here, a simple topology-based atomistic anisotropic network model (ANM) is shown which captures the protein flexibility as a fundamental property that determines the collective dynamics and hence, the protein conformations in native state. An all-atom ANM is used to define two measures of protein flexibility in the native state. One measure quantifies overall stiffness of the protein and the other one quantifies protein stiffness along a particular direction which is effectively the mechanical resistance of the protein towards external pulling force exerted along that direction. These measures are sensitive to the protein sequence and yields reliable values through computations of normal modes of the protein. ANM at an atomistic level (heavy atoms) explains the experimental (atomic force microscopy) observations viz., different mechanical stability of structurally similar but sequentially distinct proteins which, otherwise were implied to possess similar mechanical properties from analytical/theoretical coarse-grained (backbone only) models. The results are exclusively demonstrated for human fibronectin (FN) protein domains. The topology of interatomic contacts in the folded states of proteins essentially determines the native flexibility. The mechanical differences of topologically similar proteins are captured from a high-resolution (atomic level) ANM at a low computational cost. The relative trend in flexibility of such proteins is reflected in their stability differences that they exhibit while unfolding in atomic force microscopic (AFM) experiments.

Towards an on-chip platform for the controlled application of forces via magnetic particles: A novel device for mechanobiology

NASA Astrophysics Data System (ADS)

Monticelli, M.; Albisetti, E.; Petti, D.; Conca, D. V.; Falcone, M.; Sharma, P. P.; Bertacco, R.

2015-05-01

In-vitro tests and analyses are of fundamental importance for investigating biological mechanisms in cells and bio-molecules. The controlled application of forces to activate specific bio-pathways and investigate their effects, mimicking the role of the cellular environment, is becoming a prominent approach in this field. In this work, we present a non-invasive magnetic on-chip platform which allows for the manipulation of magnetic particles, through micrometric magnetic conduits of Permalloy patterned on-chip. We show, from simulations and experiments, that this technology permits to exert a finely controlled force on magnetic beads along the chip surface. This force can be tuned from few to hundreds pN by applying a variable external magnetic field.

Relative contributions of external forcing factors to circulation and hydrographic properties in a micro-tidal bay

NASA Astrophysics Data System (ADS)

Yoon, Seokjin; Kasai, Akihide

2017-11-01

The dominant external forcing factors influencing estuarine circulation differ among coastal environments. A three-dimensional regional circulation model was developed to estimate external influence indices and relative contributions of external forcing factors such as external oceanic forcing, surface heat flux, wind stress, and river discharge to circulation and hydrographic properties in Tango Bay, Japan. Model results show that in Tango Bay, where the Tsushima Warm Current passes offshore of the bay, under conditions of strong seasonal winds and river discharge, the water temperature and salinity are strongly influenced by surface heat flux and river discharge in the surface layer, respectively, while in the middle and bottom layers both are mainly controlled by open boundary conditions. The estuarine circulation is comparably influenced by all external forcing factors, the strong current, surface heat flux, wind stress, and river discharge. However, the influence degree of each forcing factor varies with temporal variations in external forcing factors as: the influence of open boundary conditions is higher in spring and early summer when the stronger current passes offshore of the bay, that of surface heat flux reflects the absolute value of surface heat flux, that of wind stress is higher in late fall and winter due to strong seasonal winds, and that of river discharge is higher in early spring due to snow-melting and summer and early fall due to flood events.

Resistance of three implant-abutment interfaces to fatigue testing

PubMed Central

RIBEIRO, Cleide Gisele; MAIA, Maria Luiza Cabral; SCHERRER, Susanne S.; CARDOSO, Antonio Carlos; WISKOTT, H. W. Anselm

2011-01-01

The design and retentive properties of implant-abutment connectors affect the mechanical resistance of implants. A number of studies have been carried out to compare the efficacy of connecting mechanisms between abutment and fixture. Objectives The aims of this study were: 1) to compare 3 implant-abutment interfaces (external hexagon, internal hexagon and cone-in-cone) regarding the fatigue resistance of the prosthetic screw, 2) to evaluate the corresponding mode of failure, and 3) to compare the results of this study with data obtained in previous studies on Nobel Biocare and Straumann connectors. Materials and Methods In order to duplicate the alternating and multivectorial intraoral loading pattern, the specimens were submitted to the rotating cantilever beam test. The implants, abutments and restoration analogs were spun around their longitudinal axes while a perpendicular force was applied to the external end. The objective was to determine the force level at which 50% of the specimens survived 106 load cycles. The mean force levels at which 50% failed and the corresponding 95% confidence intervals were determined using the staircase procedure. Results The external hexagon interface presented better than the cone-in-cone and internal hexagon interfaces. There was no significant difference between the cone-in-cone and internal hex interfaces. Conclusion Although internal connections present a more favorable design, this study did not show any advantage in terms of strength. The external hexagon connector used in this study yielded similar results to those obtained in a previous study with Nobel Biocare and Straumann systems. However, the internal connections (cone-in-cone and internal hexagon) were mechanically inferior compared to previous results. PMID:21710094

Gas arc constriction for plasma arc welding

NASA Technical Reports Server (NTRS)

McGee, William F. (Inventor); Rybicki, Daniel J. (Inventor)

1994-01-01

A welding torch for plasma arc welding apparatus has an inert gas applied circumferentially about the arc column externally of the constricting nozzle so as to apply a constricting force on the arc after it has exited the nozzle orifice and downstream of the auxiliary shielding gas. The constricting inert gas is supplied to a plenum chamber about the body of the torch and exits through a series of circumferentially disposed orifices in an annular wall forming a closure at the forward end of the constricting gas plenum chamber. The constricting force of the circumferential gas flow about the arc concentrates and focuses the arc column into a more narrow and dense column of energy after exiting the nozzle orifice so that the arc better retains its energy density prior to contacting the workpiece.

External push and internal pull forces recruit curvature sensing N-BAR domain proteins to the plasma membrane

PubMed Central

Galic, Milos; Jeong, Sangmoo; Tsai, Feng-Chiao; Joubert, Lydia-Marie; Wu, Yi I.; Hahn, Klaus M.; Cui, Yi; Meyer, Tobias

2012-01-01

Many of the more than 20 mammalian proteins with N-BAR domains1-2 control cell architecture3 and endocytosis4-5 by associating with curved sections of the plasma membrane (PM)6. It is not well understood whether N-BAR proteins are recruited directly by processes that mechanically curve the PM or indirectly by PM-associated adaptor proteins that recruit proteins with N-BAR domains that then induce membrane curvature. Here, we show that externally-induced inward deformation of the PM by cone-shaped nanostructures (Nanocones) and internally-induced inward deformation by contracting actin cables both trigger recruitment of isolated N-BAR domains to the curved PM. Markedly, live-cell imaging in adherent cells showed selective recruitment of full length N-BAR proteins and isolated N-BAR domains to PM sub-regions above Nanocone stripes. Electron microscopy confirmed that N-BAR domains are recruited to local membrane sites curved by Nanocones. We further showed that N-BAR domains are periodically recruited to curved PM sites during local lamellipodia retraction in the front of migrating cells. Recruitment required Myosin II-generated force applied to PM connected actin cables. Together, our study shows that N-BAR domains can be directly recruited to the PM by external push or internal pull forces that locally curve the PM. PMID:22750946

Tunable electronic and magnetic properties of two‐dimensional materials and their one‐dimensional derivatives

PubMed Central

Zhang, Zhuhua; Liu, Xiaofei; Yu, Jin; Hang, Yang; Li, Yao; Guo, Yufeng; Xu, Ying; Sun, Xu; Zhou, Jianxin

2016-01-01

Low‐dimensional materials exhibit many exceptional properties and functionalities which can be efficiently tuned by externally applied force or fields. Here we review the current status of research on tuning the electronic and magnetic properties of low‐dimensional carbon, boron nitride, metal‐dichalcogenides, phosphorene nanomaterials by applied engineering strain, external electric field and interaction with substrates, etc, with particular focus on the progress of computational methods and studies. We highlight the similarities and differences of the property modulation among one‐ and two‐dimensional nanomaterials. Recent breakthroughs in experimental demonstration of the tunable functionalities in typical nanostructures are also presented. Finally, prospective and challenges for applying the tunable properties into functional devices are discussed. WIREs Comput Mol Sci 2016, 6:324–350. doi: 10.1002/wcms.1251 For further resources related to this article, please visit the WIREs website. Conflict of interest: The authors have declared no conflicts of interest for this article. PMID:27818710

Delayed-feedback chimera states: Forced multiclusters and stochastic resonance

NASA Astrophysics Data System (ADS)

Semenov, V.; Zakharova, A.; Maistrenko, Y.; Schöll, E.

2016-07-01

A nonlinear oscillator model with negative time-delayed feedback is studied numerically under external deterministic and stochastic forcing. It is found that in the unforced system complex partial synchronization patterns like chimera states as well as salt-and-pepper-like solitary states arise on the route from regular dynamics to spatio-temporal chaos. The control of the dynamics by external periodic forcing is demonstrated by numerical simulations. It is shown that one-cluster and multi-cluster chimeras can be achieved by adjusting the external forcing frequency to appropriate resonance conditions. If a stochastic component is superimposed to the deterministic external forcing, chimera states can be induced in a way similar to stochastic resonance, they appear, therefore, in regimes where they do not exist without noise.

Burrowing by small polychaetes - mechanics, behavior and muscle structure of Capitella sp.

PubMed

Grill, Susann; Dorgan, Kelly M

2015-05-15

Worms of different sizes extend burrows through muddy sediments by fracture, applying dorso-ventral forces that are amplified at the crack tip. Smaller worms displace sediments less than larger worms and therefore are limited in how much force they can apply to burrow walls. We hypothesized that small worms would exhibit a transition in burrowing mechanics, specifically a lower limit in body size for the ability to burrow by fracture, corresponding with an ontogenetic transition in muscle morphology. Kinematics of burrowing in a mud analog, external morphology and muscle arrangement were examined in juveniles and adults of the small polychaete Capitella sp. We found that it moves by peristalsis, and no obvious differences were observed among worms of different sizes; even very small juveniles were able to burrow through a clear mud analog by fracture. Interestingly, we found that in addition to longitudinal and circular muscles needed for peristaltic movements, left- and right-handed helical muscles wrap around the thorax of worms of all sizes. We suggest that in small worms helical muscles may function to supplement forces generated by longitudinal muscles and to maintain hydrostatic pressure, enabling higher forces to be exerted on the crack wall. Further research is needed, however, to determine whether surficial sediments inhabited by small worms fail by fracture or plastically deform under forces of the magnitudes applied by Capitella sp. © 2015. Published by The Company of Biologists Ltd.

Defining and Testing the Influence of Servo System Response on Machine Tool Compliance

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hopkins, D J

2004-03-24

Compliance can be defined as the measurement of displacement per unit of force applied e.g. nano-meters per Newton (m/N). Compliance is the reciprocal of stiffness. High stiffness means low compliance and visa versa. It is an important factor in machine tool characteristics because it reflects the ability of the machine axis to maintain a desired position as it encounters a force or torque. Static compliance is a measurement made with a constant force applied e.g. the average depth of cut. Dynamic compliance is a measurement made as a function of frequency, e.g. a fast too servo (FTS) that applies amore » varying cutting force or load, interrupted cuts and external disturbances such as ground vibrations or air conditioning induced forces on the machine. Compliance can be defined for both a linear and rotary axis of a machine tool. However, to properly define compliance for a rotary axis, the axis must allow a commanded angular position. Note that this excludes velocity only axes. In this paper, several factors are discussed that affect compliance but emphasis is placed on how the machine servo system plays a key role in compliance at low to mid frequency regions. The paper discusses several techniques for measuring compliance and provides examples of results from these measurements.« less

Experimental and numerical investigation on laser-assisted bending of pre-loaded metal plate

NASA Astrophysics Data System (ADS)

Nowak, Zdzisław; Nowak, Marcin; Widłaszewski, Jacek; Kurp, Piotr

2018-01-01

The laser forming technique has an important disadvantage, which is the limitation of plastic deformation generated by a single laser beam pass. To increase the plastic deformation it is possible to apply external forces in the laser forming process. In this paper, we investigate the influence of external pre-loads on the laser bending of steel plate. The pre-loads investigated generate bending towards the laser beam. The thermal, elastic-plastic analysis is performed using the commercial nonlinear finite element analysis package ABAQUS. The focus of the paper is to identify how this pattern of the pre-load influence the final bend angle of the plate.

Changes in Muscle and Joint Coordination in Learning to Direct Forces

PubMed Central

Hasson, Christopher J.; Caldwell, Graham E.; van Emmerik, Richard E.A.

2008-01-01

While it has been suggested that biarticular muscles have a specialized role in directing external reaction forces, it is unclear how humans learn to coordinate mono- and bi-articular muscles to perform force-directing tasks. Subjects were asked to direct pedal forces in a specified target direction during one-legged cycling. We expected that with practice, performance improvement would be associated with specific changes in joint torque patterns and mono- and bi-articular muscular coordination. Nine male subjects practiced pedaling an ergometer with only their left leg, and were instructed to always direct their applied pedal force perpendicular to the crank arm (target direction) and to maintain a constant pedaling speed. After a single practice session, the mean error between the applied and target pedal force directions decreased significantly. This improved performance was accompanied by a significant decrease in the amount of ankle angular motion and a smaller increase in knee and hip angular motion. This coincided with a re-organization of lower extremity joint torques, with a decrease in ankle plantarflexor torque and an increase in knee and hip flexor torques. Changes were seen in both mono- and bi-articular muscle activity patterns. The monoarticular muscles exhibited greater alterations, and appeared to contribute to both mechanical work and force directing. With practice, a loosening of the coupling between biarticular thigh muscle activation and joint torque co-regulation was observed. The results demonstrated that subjects were able to learn a complex and dynamic force-directing task by changing the direction of their applied pedal forces through re-organization of joint torque patterns and mono- and bi-articular muscle coordination. PMID:18405988

Changes in muscle and joint coordination in learning to direct forces.

PubMed

Hasson, Christopher J; Caldwell, Graham E; van Emmerik, Richard E A

2008-08-01

While it has been suggested that bi-articular muscles have a specialized role in directing external reaction forces, it is unclear how humans learn to coordinate mono- and bi-articular muscles to perform force-directing tasks. Participants were asked to direct pedal forces in a specified target direction during one-legged cycling. We expected that with practice, performance improvement would be associated with specific changes in joint torque patterns and mono- and bi-articular muscular coordination. Nine male participants practiced pedaling an ergometer with only their left leg, and were instructed to always direct their applied pedal force perpendicular to the crank arm (target direction) and to maintain a constant pedaling speed. After a single practice session, the mean error between the applied and target pedal force directions decreased significantly. This improved performance was accompanied by a significant decrease in the amount of ankle angular motion and a smaller increase in knee and hip angular motion. This coincided with a re-organization of lower extremity joint torques, with a decrease in ankle plantarflexor torque and an increase in knee and hip flexor torques. Changes were seen in both mono- and bi-articular muscle activity patterns. The mono-articular muscles exhibited greater alterations, and appeared to contribute to both mechanical work and force-directing. With practice, a loosening of the coupling between bi-articular thigh muscle activation and joint torque co-regulation was observed. The results demonstrated that participants were able to learn a complex and dynamic force-directing task by changing the direction of their applied pedal forces through re-organization of joint torque patterns and mono- and bi-articular muscle coordination.

A droplet-based passive force sensor for remote tactile sensing applications

NASA Astrophysics Data System (ADS)

Nie, Baoqing; Yao, Ting; Zhang, Yiqiu; Liu, Jian; Chen, Xinjian

2018-01-01

A droplet-based flexible wireless force sensor has been developed for remote tactile-sensing applications. By integration of a droplet-based capacitive sensing unit and two circular planar coils, this inductor-capacitor (LC) passive sensor offers a platform for the mechanical force detection in a wireless transmitting mode. Under external loads, the membrane surface of the sensor deforms the underlying elastic droplet uniformly, introducing a capacitance response in tens of picofarads. The LC circuit transduces the applied force into corresponding variations of its resonance frequency, which is detected by an external electromagnetic coupling coil. Specifically, the liquid droplet features a mechanosensitive plasticity, which results in an increased device sensitivity as high as 2.72 MHz N-1. The high dielectric property of the droplet endows our sensor with high tolerance for noise and large capacitance values (20-40 pF), the highest value in the literature for the LC passive devices in comparable dimensions. It achieves excellent reproducibility under periodical loads ranging from 0 to 1.56 N and temperature fluctuations ranging from 10 °C to 55 °C. As an interesting conceptual demonstration, the flexible device has been configured into a fingertip-amounted setting in a highly compact package (of 11 mm × 11 mm × 0.25 mm) for remote contact force sensing in the table tennis game.

Electrostatically frequency tunable micro-beam-based piezoelectric fluid flow energy harvester

NASA Astrophysics Data System (ADS)

Rezaee, Mousa; Sharafkhani, Naser

2017-07-01

This research investigates the dynamic behavior of a sandwich micro-beam based piezoelectric energy harvester with electrostatically adjustable resonance frequency. The system consists of a cantilever micro-beam immersed in a fluid domain and is subjected to the simultaneous action of cross fluid flow and nonlinear electrostatic force. Two parallel piezoelectric laminates are extended along the length of the micro-beam and connected to an external electric circuit which generates an output power as a result of the micro-beam oscillations. The fluid-coupled structure is modeled using Euler-Bernoulli beam theory and the equivalent force terms for the fluid flow. Fluid induced forces comprise the added inertia force which is evaluated using equivalent added mass and the drag and lift forces which are evaluated using relative velocity and Van der Pol equation. In addition to flow velocity and fluid density, the influence of several design parameters such as external electrical resistance, piezo layer position, and dc voltage on the generated power are investigated by using Galerkin and step by step linearization method. It is shown that for given flowing fluid parameters, i.e., density and velocity, one can adjust the applied dc voltage to tune resonance frequency so that the lock-in phenomenon with steady large amplitude oscillations happens, also by adjusting the harvester parameters including the mechanical and electrical ones, the maximal output power of the harvester becomes possible.

Aluminum reduction cell electrode

DOEpatents

Goodnow, W.H.; Payne, J.R.

1982-09-14

The invention is directed to cathode modules comprised of refractory hard metal materials, such as TiB[sub 2], for an electrolytic cell for the reduction of alumina wherein the modules may be installed and replaced during operation of the cell and wherein the structure of the cathode modules is such that the refractory hard metal materials are not subjected to externally applied forces or rigid constraints. 9 figs.

Global Stability and Dynamics of Strongly Nonlinear Systems Using Koopman Operator Theory

DTIC Science & Technology

2017-03-01

calculus, applied mathematics, Director’s Research Initiative 16. SECURITY CLASSIFICATION OF: 17. LIMITATION OF ABSTRACT UU 18... research of Svenkeson et al.4 Section 2 is Accomplishments and Section 3 is the Conclusion. 2. Accomplishments 2.1 Prescribed External Forcing To study ...ARL-TR-7959 MAR 2017 US Army Research Laboratory Global Stability and Dynamics of Strongly Nonlinear Systems Using Koopman

Visual Cues of Motion That Trigger Animacy Perception at Birth: The Case of Self-Propulsion

ERIC Educational Resources Information Center

Di Giorgio, Elisa; Lunghi, Marco; Simion, Francesca; Vallortigara, Giorgio

2017-01-01

Self-propelled motion is a powerful cue that conveys information that an object is animate. In this case, animate refers to an entity's capacity to initiate motion without an applied external force. Sensitivity to this motion cue is present in infants that are a few months old, but whether this sensitivity is experience-dependent or is already…

Piezotronic Effect in Polarity-Controlled GaN Nanowires.

PubMed

Zhao, Zhenfu; Pu, Xiong; Han, Changbao; Du, Chunhua; Li, Linxuan; Jiang, Chunyan; Hu, Weiguo; Wang, Zhong Lin

2015-08-25

Using high-quality and polarity-controlled GaN nanowires (NWs), we studied the piezotronic effect in crystal orientation defined wurtzite structures. By applying a normal compressive force on c-plane GaN NWs with an atomic force microscopy tip, the Schottky barrier between the Pt tip and GaN can be effectively tuned by the piezotronic effect. In contrast, the normal compressive force cannot change the electron transport characteristics in m-plane GaN NWs whose piezoelectric polarization axis is turned in the transverse direction. This observation provided solid evidence for clarifying the difference between the piezotronic effect and the piezoresistive effect. We further demonstrated a high sensitivity of the m-plane GaN piezotronic transistor to collect the transverse force. The integration of c-plane GaN and m-plane GaN indicates an overall response to an external force in any direction.

Kinematics and force analysis of a robot hand based on an artificial biological control scheme

NASA Astrophysics Data System (ADS)

Kim, Man Guen

An artificial biological control scheme (ABCS) is used to study the kinematics and statics of a multifingered hand with a view to developing an efficient control scheme for grasping. The ABCS is based on observation of human grasping, intuitively taking it as the optimum model for robotic grasping. A final chapter proposes several grasping measures to be applied to the design and control of a robot hand. The ABCS leads to the definition of two modes of the grasping action: natural grasping (NG), which is the human motion to grasp the object without any special task command, and forced grasping (FG), which is the motion with a specific task. The grasping direction line (GDL) is defined to determine the position and orientation of the object in the hand. The kinematic model of a redundant robot arm and hand is developed by reconstructing the human upper extremity and using anthropometric measurement data. The inverse kinematic analyses of various types of precision and power grasping are studied by replacing the three-link with one virtual link and using the GDL. The static force analysis for grasping with fingertips is studied by applying the ABCS. A measure of grasping stability, that maintains the positions of contacts as well as the configurations of the redundant fingers, is derived. The grasping stability measure (GSM), a measure of how well the hand maintains grasping under the existence of external disturbance, is derived by the torque vector of the hand calculated from the external force applied to the object. The grasping manipulability measure (GMM), a measure of how well the hand manipulates the object for the task, is derived by the joint velocity vector of the hand calculated from the object velocity. The grasping performance measure (GPM) is defined by the sum of the directional components of the GSM and the GMM. Finally, a planar redundant hand with two fingers is examined in order to study the various postures of the hand performing pinch grasping by applying the GSM and the GMM.

Physics models of centriole replication.

PubMed

Cheng, Kang; Zou, Changhua

2006-01-01

Our previous pre-clinic experimental results have showed that the epithelialization can be enhanced by the externally applied rectangular pulsed electrical current stimulation (RPECS). The results are clinically significant for patients, especially for those difficult patients whose skin wounds need long periods to heal. However, the results also raise questions: How does the RPECS accelerate the epithelium cell proliferation? To answer these questions, we have previously developed several models for animal cells, in a view of physics, to explain mechanisms of mitosis and cytokinesis at a cellular level, and separation of nucleotide sequences and the unwinding of a double helix during DNA replication at a bio-molecular level. In this paper, we further model the mechanism of centriole replication during a natural and normal mitosis and cytokinesis to explore the mechanism of epithelialization enhanced with the externally applied RPECS at a bio-molecular level. Our models suggest: (1) Centriole replication is an information flowing. The direction of the information flowing is from centrioles to centrioles based on a cylindrical template of 9 x 3 protein microtubules (MTs) pattern. (2) A spontaneous and strong electromagnetic field (EMF) force is a pushing force that separates a mother and a daughter centrioles in centrosomes or in cells, while a pulling force of interacting fibers and pericentriolar materials delivers new babies. The newly born babies inherit the pattern information from their mother(s) and grow using microtubule fragments that come through the centrosome pores. A daughter centriole is always born and grows along stronger EMF. The EMF mostly determines centrioles positions and plays key role in centriole replication. We also hypothesize that the normal centriole replication could not been disturbed in centrosome in the epithelium cells by our RPECS, because the centrioles have two non-conducting envelope (cell and centrosome membranes), that protect the normal duplication. The induced electric field by externally applied RPECS could be mild compared with the spontaneous and natural electric field of the centrioles. Therefore, the centriole replication during the epithelium cellular proliferation may be directly, as well as indirectly (e.g., somatic reflex) accelerated by the RPECS.

Harmonic force spectroscopy measures load-dependent kinetics of individual human β-cardiac myosin molecules.

PubMed

Sung, Jongmin; Nag, Suman; Mortensen, Kim I; Vestergaard, Christian L; Sutton, Shirley; Ruppel, Kathleen; Flyvbjerg, Henrik; Spudich, James A

2015-08-04

Molecular motors are responsible for numerous cellular processes from cargo transport to heart contraction. Their interactions with other cellular components are often transient and exhibit kinetics that depend on load. Here, we measure such interactions using 'harmonic force spectroscopy'. In this method, harmonic oscillation of the sample stage of a laser trap immediately, automatically and randomly applies sinusoidally varying loads to a single motor molecule interacting with a single track along which it moves. The experimental protocol and the data analysis are simple, fast and efficient. The protocol accumulates statistics fast enough to deliver single-molecule results from single-molecule experiments. We demonstrate the method's performance by measuring the force-dependent kinetics of individual human β-cardiac myosin molecules interacting with an actin filament at physiological ATP concentration. We show that a molecule's ADP release rate depends exponentially on the applied load, in qualitative agreement with cardiac muscle, which contracts with a velocity inversely proportional to external load.

Harmonic force spectroscopy measures load-dependent kinetics of individual human β-cardiac myosin molecules

PubMed Central

Sung, Jongmin; Nag, Suman; Mortensen, Kim I.; Vestergaard, Christian L.; Sutton, Shirley; Ruppel, Kathleen; Flyvbjerg, Henrik; Spudich, James A.

2015-01-01

Molecular motors are responsible for numerous cellular processes from cargo transport to heart contraction. Their interactions with other cellular components are often transient and exhibit kinetics that depend on load. Here, we measure such interactions using ‘harmonic force spectroscopy'. In this method, harmonic oscillation of the sample stage of a laser trap immediately, automatically and randomly applies sinusoidally varying loads to a single motor molecule interacting with a single track along which it moves. The experimental protocol and the data analysis are simple, fast and efficient. The protocol accumulates statistics fast enough to deliver single-molecule results from single-molecule experiments. We demonstrate the method's performance by measuring the force-dependent kinetics of individual human β-cardiac myosin molecules interacting with an actin filament at physiological ATP concentration. We show that a molecule's ADP release rate depends exponentially on the applied load, in qualitative agreement with cardiac muscle, which contracts with a velocity inversely proportional to external load. PMID:26239258

A new technique using roentgen stereophotogrammetry to measure changes in the spatial conformation of bovine hind claws in response to external loads.

PubMed

Ouweltjes, W; Gussekloo, S W S; Spoor, C W; van Leeuwen, J L

2016-02-01

Claw and locomotion problems are widespread in ungulates. Although it is presumed that mechanical overload is an important contributor to claw tissue damage and impaired locomotion, deformation and claw injury as a result of mechanical loading has been poorly quantified and, as a result, practical solutions to reduce such lesions have been established mostly through trial and error. In this study, an experimental technique was developed that allowed the measurement under controlled loading regimes of minute deformations in the lower limbs of dissected specimens from large ungulates. Roentgen stereophotogrammetric analysis (RSA) was applied to obtain 3D marker coordinates with an accuracy of up to 0.1 mm with optimal contrast and to determine changes in the spatial conformation. A force plate was used to record the applied forces in three dimensions. The results obtained for a test sample (cattle hind leg) under three loading conditions showed that small load-induced deformations and translations as well as small changes in centres of force application could be measured. Accuracy of the order of 0.2-0.3 mm was feasible under practical circumstances with suboptimal contrast. These quantifications of claw deformation during loading improve understanding of the spatial strain distribution as a result of external loading and the risks of tissue overload. The method promises to be useful in determining load-deformation relationships for a wide variety of specimens and circumstances. Copyright © 2015 Elsevier Ltd. All rights reserved.

Fatigue tests of YBCO coated conductors

NASA Astrophysics Data System (ADS)

Bamba, S.; Tanaka, Y.; Ando, T.; Ueda, H.; Ishiyama, A.; Yamada, Y.; Shiohara, Y.

2008-02-01

In this paper, we report the fatigue characteristics of IBAD/PLD YBCO coated conductors. A YBCO coated conductor used in the superconducting coil of a SMES system is repeatedly subjected to mechanical tensile or compressive strain due to the Lorentz force during electrical charging or discharging. The superconducting characteristic of this conductor may deteriorate because of this cyclic strain. Therefore, it is necessary to investigate the effect of cyclic strain on the superconducting characteristics of YBCO coated conductors that have a laminated structure. We developed an experimental apparatus with a U-shaped sample holder in order to apply cyclic strain to the sample tape. This apparatus was used to perform the fatigue tests on YBCO coated conductors in liquid nitrogen in the absence of an external magnetic field. The strain cycles with the maximum strain epsilonmax (zero external strain → epsilonmax → zero external strain) were applied and repeated up to 5000 times, and the Ic measurements were performed at epsilonmax. Therefore, the application of cyclic strain with epsilonmax ranging from 0.3% to 0.5% did not result in any significant deterioration of the superconducting characteristics of the conductor.

Fracture of a composite reinforced by unidirectional fibers

NASA Astrophysics Data System (ADS)

Hasanov, F. F.

2014-11-01

An elastic medium weakened by a periodic system of circular holes filled with homogeneous elastic fibers whose surface is coated with a homogeneous film is considered. A fracture model for a medium with a periodic structure is proposed, which is based on an analysis of the fracture zone near the crack tip. It is assumed that the fracture zone is a layer of finite length containing a material with partially broken bonds between separate structural elements (end zone). The fracture zone is considered as part of the crack. The bonds between crack faces in the end zone are modeled by applying the cohesive forces caused by the presence of bonds to the crack surface. An analysis of the limit equilibrium of shear cracks in the end zone of the model is performed on the basis of a nonlocal fracture criterion together with a force condition for the motion of crack tip and a deformation condition for determining the motion of faces of end-zone cracks. In the analysis, relationships between the cohesive forces and the shear of crack faces are established, the stress state near the crack is assessed with account of external loading, cohesive forces, and fiber arrangement, and the critical external loads as functions of geometric parameters of the composite are determined.

Contact-force distribution optimization and control for quadruped robots using both gradient and adaptive neural networks.

PubMed

Li, Zhijun; Ge, Shuzhi Sam; Liu, Sibang

2014-08-01

This paper investigates optimal feet forces' distribution and control of quadruped robots under external disturbance forces. First, we formulate a constrained dynamics of quadruped robots and derive a reduced-order dynamical model of motion/force. Consider an external wrench on quadruped robots; the distribution of required forces and moments on the supporting legs of a quadruped robot is handled as a tip-point force distribution and used to equilibrate the external wrench. Then, a gradient neural network is adopted to deal with the optimized objective function formulated as to minimize this quadratic objective function subjected to linear equality and inequality constraints. For the obtained optimized tip-point force and the motion of legs, we propose the hybrid motion/force control based on an adaptive neural network to compensate for the perturbations in the environment and approximate feedforward force and impedance of the leg joints. The proposed control can confront the uncertainties including approximation error and external perturbation. The verification of the proposed control is conducted using a simulation.

Dynamics of Individual cilia to external loading- A simple one dimensional picture

NASA Astrophysics Data System (ADS)

Swaminathan, Vinay; Hill, David; Superfine, R.

2008-10-01

From being called the cellular janitors to swinging debauchers, cilia have captured the fascinations of researchers for over 200 years. In cystic fibrosis and chronic obstructive pulmonary disease where the cilia loses it's function, the protective mucus layer in the lung thickens and mucociliary clearance breaks down, leading to inflammation along the airways and an increased rate of infection. The mechanistic understanding of mucus clearance depends on a quantitative assessment of the axoneme dynamics and the maximum force the cilia are capable of generating and imparting to the mucus layer. Similar to the situation in molecular motors, detailed quantitative measurements of dynamics under applied load conditions are expected to be essential in developing predictive models. Based on our measurements of the dynamics of individual ciliary motion in the human bronchial epithelial cell under the application of an applied load, we present a simple one dimensional model for the axoneme dynamics and quantify the axoneme stiffness, the internal force generated by the axoneme, the stall force and show how the dynamics sheds insight on the time dependence of the internal force generation. The internal force generated by the axoneme is related to the ability of cilia to propel fluids and to their potential role in force sensing.

Magnetic force microscopy studies in bulk polycrystalline iron

NASA Astrophysics Data System (ADS)

Abuthahir, J.; Kumar, Anish

2018-02-01

The paper presents magnetic force microscopy (MFM) studies on the effect of crystallographic orientation and external magnetic field on magnetic microstructure in a bulk polycrystalline iron specimen. The magneto crystalline anisotropic effect on the domain structure is characterized with the support of electron backscatter diffraction study. The distinct variations in magnetic domain structure are observed based on the crystallographic orientation of the grain surface normal with respect to the cube axis i.e. the easy axis of magnetization. Further, the local magnetization behavior is studied in-situ by MFM in presence of external magnetic field in the range of -2000 to 2000 Oe. Various micro-magnetization phenomena such as reversible and irreversible domain wall movements, expansion and contraction of domains, Barkhausen jump, bowing of a pinned domain wall and nucleation of a spike domain are visualized. The respective changes in the magnetic microstructure are compared with the bulk magnetization obtained using vibrating sample magnetometer. Bowing of a domain wall, pinned at two points, upon application of magnetic field is used to estimate the domain wall energy density. The MFM studies in presence of external field applied in two perpendicular directions are used to reveal the influence of the crystalline anisotropy on the local micro-magnetization.

Femoral Component External Rotation Affects Knee Biomechanics: A Computational Model of Posterior-stabilized TKA.

PubMed

Kia, Mohammad; Wright, Timothy M; Cross, Michael B; Mayman, David J; Pearle, Andrew D; Sculco, Peter K; Westrich, Geoffrey H; Imhauser, Carl W

2018-01-01

The correct amount of external rotation of the femoral component during TKA is controversial because the resulting changes in biomechanical knee function associated with varying degrees of femoral component rotation are not well understood. We addressed this question using a computational model, which allowed us to isolate the biomechanical impact of geometric factors including bony shapes, location of ligament insertions, and implant size across three different knees after posterior-stabilized (PS) TKA. Using a computational model of the tibiofemoral joint, we asked: (1) Does external rotation unload the medial collateral ligament (MCL) and what is the effect on lateral collateral ligament tension? (2) How does external rotation alter tibiofemoral contact loads and kinematics? (3) Does 3° external rotation relative to the posterior condylar axis align the component to the surgical transepicondylar axis (sTEA) and what anatomic factors of the femoral condyle explain variations in maximum MCL tension among knees? We incorporated a PS TKA into a previously developed computational knee model applied to three neutrally aligned, nonarthritic, male cadaveric knees. The computational knee model was previously shown to corroborate coupled motions and ligament loading patterns of the native knee through a range of flexion. Implant geometries were virtually installed using hip-to-ankle CT scans through measured resection and anterior referencing surgical techniques. Collateral ligament properties were standardized across each knee model by defining stiffness and slack lengths based on the healthy population. The femoral component was externally rotated from 0° to 9° relative to the posterior condylar axis in 3° increments. At each increment, the knee was flexed under 500 N compression from 0° to 90° simulating an intraoperative examination. The computational model predicted collateral ligament forces, compartmental contact forces, and tibiofemoral internal/external and varus-valgus rotation through the flexion range. The computational model predicted that femoral component external rotation relative to the posterior condylar axis unloads the MCL and the medial compartment; however, these effects were inconsistent from knee to knee. When the femoral component was externally rotated by 9° rather than 0° in knees one, two, and three, the maximum force carried by the MCL decreased a respective 55, 88, and 297 N; the medial contact forces decreased at most a respective 90, 190, and 570 N; external tibial rotation in early flexion increased by a respective 4.6°, 1.1°, and 3.3°; and varus angulation of the tibia relative to the femur in late flexion increased by 8.4°, 8.0°, and 7.9°, respectively. With 3° of femoral component external rotation relative to the posterior condylar axis, the femoral component was still externally rotated by up to 2.7° relative to the sTEA in these three neutrally aligned knees. Variations in MCL force from knee to knee with 3° of femoral component external rotation were related to the ratio of the distances from the femoral insertion of the MCL to the posterior and distal cuts of the implant; the closer this ratio was to 1, the more uniform were the MCL tensions from 0° to 90° flexion. A larger ratio of distances from the femoral insertion of the MCL to the posterior and distal cuts may cause clinically relevant increases in both MCL tension and compartmental contact forces. To obtain more consistent ligament tensions through flexion, it may be important to locate the posterior and distal aspects of the femoral component with respect to the proximal insertion of the MCL such that a ratio of 1 is achieved.

Evidence for external forcing of the Atlantic Multidecadal Oscillation since termination of the Little Ice Age

PubMed Central

Knudsen, Mads Faurschou; Jacobsen, Bo Holm; Seidenkrantz, Marit-Solveig; Olsen, Jesper

2014-01-01

The Atlantic Multidecadal Oscillation (AMO) represents a significant driver of Northern Hemisphere climate, but the forcing mechanisms pacing the AMO remain poorly understood. Here we use the available proxy records to investigate the influence of solar and volcanic forcing on the AMO over the last ~450 years. The evidence suggests that external forcing played a dominant role in pacing the AMO after termination of the Little Ice Age (LIA; ca. 1400–1800), with an instantaneous impact on mid-latitude sea-surface temperatures that spread across the North Atlantic over the ensuing ~5 years. In contrast, the role of external forcing was more ambiguous during the LIA. Our study further suggests that the Atlantic Meridional Overturning Circulation is important for linking external forcing with North Atlantic sea-surface temperatures, a conjecture that reconciles two opposing theories concerning the origin of the AMO. PMID:24567051

Evidence for external forcing of the Atlantic Multidecadal Oscillation since termination of the Little Ice Age.

PubMed

Knudsen, Mads Faurschou; Jacobsen, Bo Holm; Seidenkrantz, Marit-Solveig; Olsen, Jesper

2014-02-25

The Atlantic Multidecadal Oscillation (AMO) represents a significant driver of Northern Hemisphere climate, but the forcing mechanisms pacing the AMO remain poorly understood. Here we use the available proxy records to investigate the influence of solar and volcanic forcing on the AMO over the last ~450 years. The evidence suggests that external forcing played a dominant role in pacing the AMO after termination of the Little Ice Age (LIA; ca. 1400-1800), with an instantaneous impact on mid-latitude sea-surface temperatures that spread across the North Atlantic over the ensuing ~5 years. In contrast, the role of external forcing was more ambiguous during the LIA. Our study further suggests that the Atlantic Meridional Overturning Circulation is important for linking external forcing with North Atlantic sea-surface temperatures, a conjecture that reconciles two opposing theories concerning the origin of the AMO.

Nation-scale adoption of new medicines by doctors: an application of the Bass diffusion model

PubMed Central

2012-01-01

Background The adoption of new medicines is influenced by a complex set of social processes that have been widely examined in terms of individual prescribers’ information-seeking and decision-making behaviour. However, quantitative, population-wide analyses of how long it takes for new healthcare practices to become part of mainstream practice are rare. Methods We applied a Bass diffusion model to monthly prescription volumes of 103 often-prescribed drugs in Australia (monthly time series data totalling 803 million prescriptions between 1992 and 2010), to determine the distribution of adoption rates. Our aim was to test the utility of applying the Bass diffusion model to national-scale prescribing volumes. Results The Bass diffusion model was fitted to the adoption of a broad cross-section of drugs using national monthly prescription volumes from Australia (median R2 = 0.97, interquartile range 0.95 to 0.99). The median time to adoption was 8.2 years (IQR 4.9 to 12.1). The model distinguished two classes of prescribing patterns – those where adoption appeared to be driven mostly by external forces (19 drugs) and those driven mostly by social contagion (84 drugs). Those driven more prominently by internal forces were found to have shorter adoption times (p = 0.02 in a non-parametric analysis of variance by ranks). Conclusion The Bass diffusion model may be used to retrospectively represent the patterns of adoption exhibited in prescription volumes in Australia, and distinguishes between adoption driven primarily by external forces such as regulation, or internal forces such as social contagion. The eight-year delay between the introduction of a new medicine and the adoption of the prescribing practice suggests the presence of system inertia in Australian prescribing practices. PMID:22876867

A review of analogue modelling of geodynamic processes: Approaches, scaling, materials and quantification, with an application to subduction experiments

NASA Astrophysics Data System (ADS)

Schellart, Wouter P.; Strak, Vincent

2016-10-01

We present a review of the analogue modelling method, which has been used for 200 years, and continues to be used, to investigate geological phenomena and geodynamic processes. We particularly focus on the following four components: (1) the different fundamental modelling approaches that exist in analogue modelling; (2) the scaling theory and scaling of topography; (3) the different materials and rheologies that are used to simulate the complex behaviour of rocks; and (4) a range of recording techniques that are used for qualitative and quantitative analyses and interpretations of analogue models. Furthermore, we apply these four components to laboratory-based subduction models and describe some of the issues at hand with modelling such systems. Over the last 200 years, a wide variety of analogue materials have been used with different rheologies, including viscous materials (e.g. syrups, silicones, water), brittle materials (e.g. granular materials such as sand, microspheres and sugar), plastic materials (e.g. plasticine), visco-plastic materials (e.g. paraffin, waxes, petrolatum) and visco-elasto-plastic materials (e.g. hydrocarbon compounds and gelatins). These materials have been used in many different set-ups to study processes from the microscale, such as porphyroclast rotation, to the mantle scale, such as subduction and mantle convection. Despite the wide variety of modelling materials and great diversity in model set-ups and processes investigated, all laboratory experiments can be classified into one of three different categories based on three fundamental modelling approaches that have been used in analogue modelling: (1) The external approach, (2) the combined (external + internal) approach, and (3) the internal approach. In the external approach and combined approach, energy is added to the experimental system through the external application of a velocity, temperature gradient or a material influx (or a combination thereof), and so the system is open. In the external approach, all deformation in the system is driven by the externally imposed condition, while in the combined approach, part of the deformation is driven by buoyancy forces internal to the system. In the internal approach, all deformation is driven by buoyancy forces internal to the system and so the system is closed and no energy is added during an experimental run. In the combined approach, the externally imposed force or added energy is generally not quantified nor compared to the internal buoyancy force or potential energy of the system, and so it is not known if these experiments are properly scaled with respect to nature. The scaling theory requires that analogue models are geometrically, kinematically and dynamically similar to the natural prototype. Direct scaling of topography in laboratory models indicates that it is often significantly exaggerated. This can be ascribed to (1) The lack of isostatic compensation, which causes topography to be too high. (2) The lack of erosion, which causes topography to be too high. (3) The incorrect scaling of topography when density contrasts are scaled (rather than densities); In isostatically supported models, scaling of density contrasts requires an adjustment of the scaled topography by applying a topographic correction factor. (4) The incorrect scaling of externally imposed boundary conditions in isostatically supported experiments using the combined approach; When externally imposed forces are too high, this creates topography that is too high. Other processes that also affect surface topography in laboratory models but not in nature (or only in a negligible way) include surface tension (for models using fluids) and shear zone dilatation (for models using granular material), but these will generally only affect the model surface topography on relatively short horizontal length scales of the order of several mm across material boundaries and shear zones, respectively.

Stability of aerosol droplets in Bessel beam optical traps under constant and pulsed external forces

NASA Astrophysics Data System (ADS)

David, Grégory; Esat, Kıvanç; Hartweg, Sebastian; Cremer, Johannes; Chasovskikh, Egor; Signorell, Ruth

2015-04-01

We report on the dynamics of aerosol droplets in optical traps under the influence of additional constant and pulsed external forces. Experimental results are compared with simulations of the three-dimensional droplet dynamics for two types of optical traps, the counter-propagating Bessel beam (CPBB) trap and the quadruple Bessel beam (QBB) trap. Under the influence of a constant gas flow (constant external force), the QBB trap is found to be more stable compared with the CPBB trap. By contrast, under pulsed laser excitation with laser pulse durations of nanoseconds (pulsed external force), the type of trap is of minor importance for the droplet stability. It typically needs pulsed laser forces that are several orders of magnitude higher than the optical forces to induce escape of the droplet from the trap. If the droplet strongly absorbs the pulsed laser light, these escape forces can be strongly reduced. The lower stability of absorbing droplets is a result of secondary thermal processes that cause droplet escape.

Stability of aerosol droplets in Bessel beam optical traps under constant and pulsed external forces.

PubMed

David, Grégory; Esat, Kıvanç; Hartweg, Sebastian; Cremer, Johannes; Chasovskikh, Egor; Signorell, Ruth

2015-04-21

We report on the dynamics of aerosol droplets in optical traps under the influence of additional constant and pulsed external forces. Experimental results are compared with simulations of the three-dimensional droplet dynamics for two types of optical traps, the counter-propagating Bessel beam (CPBB) trap and the quadruple Bessel beam (QBB) trap. Under the influence of a constant gas flow (constant external force), the QBB trap is found to be more stable compared with the CPBB trap. By contrast, under pulsed laser excitation with laser pulse durations of nanoseconds (pulsed external force), the type of trap is of minor importance for the droplet stability. It typically needs pulsed laser forces that are several orders of magnitude higher than the optical forces to induce escape of the droplet from the trap. If the droplet strongly absorbs the pulsed laser light, these escape forces can be strongly reduced. The lower stability of absorbing droplets is a result of secondary thermal processes that cause droplet escape.

High Reynolds number turbulence model of rotating shear flows

NASA Astrophysics Data System (ADS)

Masuda, S.; Ariga, I.; Koyama, H. S.

1983-09-01

A Reynolds stress closure model for rotating turbulent shear flows is developed. Special attention is paid to keeping the model constants independent of rotation. First, general forms of the model of a Reynolds stress equation and a dissipation rate equation are derived, the only restrictions of which are high Reynolds number and incompressibility. The model equations are then applied to two-dimensional equilibrium boundary layers and the effects of Coriolis acceleration on turbulence structures are discussed. Comparisons with the experimental data and with previous results in other external force fields show that there exists a very close analogy between centrifugal, buoyancy and Coriolis force fields. Finally, the model is applied to predict the two-dimensional boundary layers on rotating plane walls. Comparisons with existing data confirmed its capability of predicting mean and turbulent quantities without employing any empirical relations in rotating fields.

Cell partition in two phase polymer systems

NASA Technical Reports Server (NTRS)

Brooks, D. E.

1979-01-01

Aqueous phase-separated polymer solutions can be used as support media for the partition of biological macromolecules, organelles and cells. Cell separations using the technique have proven to be extremely sensitive to cell surface properties but application of the systems are limited to cells or aggregates which do not significantly while the phases are settling. Partition in zero g in principle removes this limitation but an external driving force must be applied to induce the phases to separate since their density difference disappears. We have recently shown that an applied electric field can supply the necessary driving force. We are proposing to utilize the NASA FES to study field-driven phase separation and cell partition on the ground and in zero g to help define the separation/partition process, with the ultimate goal being to develop partition as a zero g cell separation technique.

Selective effects of weight and inertia on maximum lifting.

PubMed

Leontijevic, B; Pazin, N; Kukolj, M; Ugarkovic, D; Jaric, S

2013-03-01

A novel loading method (loading ranged from 20% to 80% of 1RM) was applied to explore the selective effects of externally added simulated weight (exerted by stretched rubber bands pulling downward), weight+inertia (external weights added), and inertia (covariation of the weights and the rubber bands pulling upward) on maximum bench press throws. 14 skilled participants revealed a load associated decrease in peak velocity that was the least associated with an increase in weight (42%) and the most associated with weight+inertia (66%). However, the peak lifting force increased markedly with an increase in both weight (151%) and weight+inertia (160%), but not with inertia (13%). As a consequence, the peak power output increased most with weight (59%), weight+inertia revealed a maximum at intermediate loads (23%), while inertia was associated with a gradual decrease in the peak power output (42%). The obtained findings could be of importance for our understanding of mechanical properties of human muscular system when acting against different types of external resistance. Regarding the possible application in standard athletic training and rehabilitation procedures, the results speak in favor of applying extended elastic bands which provide higher movement velocity and muscle power output than the usually applied weights. © Georg Thieme Verlag KG Stuttgart · New York.

Fundamental considerations in ski binding analysis.

PubMed

Mote, C D; Hull, M L

1976-01-01

1. The static adjustment of a ski binding by hand or by available machines is only an adjustment and is neither a static nor a dynamic evaluation of the binding design. Bindings of different design with identical static adjustments will perform differently in environments in which the forces are static or dynamic. 2. The concept of binding release force is a useful measure of binding adjustment, but it is inappropriate as a criterion for binding evaluation. First, it does not direct attention toward the injury causing mechanism, strain, or displacement in the leg. Second, it is only part of the evaluation in dynamic problems. 3. The binding release decision in present bindings is displacement controlled. The relative displacement of the boot and ski is the system variable. For any specified relative displacement the binding force can be any of an infinite number of possibilities determined by the loading path. 4. The response of the leg-ski system to external impulses applied to the ski is independent of the boot-ski relative motion as long as the boot recenters quickly in the binding. Response is dependent upon the external impulse plus system inertia, damping and stiffness. 5. When tested under half sinusoidal forces applied to a test ski, all bindings will demonstrate static and impulse loading regions. In the static region the force drives the binding to a relative release displacement. In the impulse region the initial velocity of the ski drives the binding to a release displacement. 6. The transition between the static and impulse loading regions is determined by the binding's capacity to store and dissipate energy along the principal loading path. Increased energy capacity necessitates larger external impulses to produce release. 7. In all bindings examined to date, the transmitted leg displacement or strain at release under static loading exceeds leg strain under dynamic or impact loading. Because static loading is responsible for many injuries, a skier should be able to release his bindings in every mode by simply pulling or twisting his foot outward. If that cannot be done without injury, the skier has identified for himself one type of fall that will result in injury. 8. And lastly, a little advice from Ben Franklin--"Carelessness does more harm than a want of knowledge."

Acta Mechanica Sinica (Selected Articles),

DTIC Science & Technology

1985-12-05

done by an external force. In the 1930’s, Trefftz and Kappus [8 ] also applied this principle to derive the elastic buckling equation and stability...theorie der stabilitat des elastischen gleichgewichts, Zeit. fur Angew. Math. u Mech. B13 (1933), L... 160. 120 [8] Kappus , R., Zur elastizitats...strain relations and boundary condiiomns for the prebeckling fundamental path solution. As Kappus had done in 1939, a new variation 6* can be imposed m

Real-time deformation of human soft tissues: A radial basis meshless 3D model based on Marquardt's algorithm.

PubMed

Zhou, Jianyong; Luo, Zu; Li, Chunquan; Deng, Mi

2018-01-01

When the meshless method is used to establish the mathematical-mechanical model of human soft tissues, it is necessary to define the space occupied by human tissues as the problem domain and the boundary of the domain as the surface of those tissues. Nodes should be distributed in both the problem domain and on the boundaries. Under external force, the displacement of the node is computed by the meshless method to represent the deformation of biological soft tissues. However, computation by the meshless method consumes too much time, which will affect the simulation of real-time deformation of human tissues in virtual surgery. In this article, the Marquardt's Algorithm is proposed to fit the nodal displacement at the problem domain's boundary and obtain the relationship between surface deformation and force. When different external forces are applied, the deformation of soft tissues can be quickly obtained based on this relationship. The analysis and discussion show that the improved model equations with Marquardt's Algorithm not only can simulate the deformation in real-time but also preserve the authenticity of the deformation model's physical properties. Copyright © 2017 Elsevier B.V. All rights reserved.

Preserving Lagrangian Structure in Nonlinear Model Reduction with Application to Structural Dynamics

DOE PAGES

Carlberg, Kevin; Tuminaro, Ray; Boggs, Paul

2015-03-11

Our work proposes a model-reduction methodology that preserves Lagrangian structure and achieves computational efficiency in the presence of high-order nonlinearities and arbitrary parameter dependence. As such, the resulting reduced-order model retains key properties such as energy conservation and symplectic time-evolution maps. We focus on parameterized simple mechanical systems subjected to Rayleigh damping and external forces, and consider an application to nonlinear structural dynamics. To preserve structure, the method first approximates the system's “Lagrangian ingredients''---the Riemannian metric, the potential-energy function, the dissipation function, and the external force---and subsequently derives reduced-order equations of motion by applying the (forced) Euler--Lagrange equation with thesemore » quantities. Moreover, from the algebraic perspective, key contributions include two efficient techniques for approximating parameterized reduced matrices while preserving symmetry and positive definiteness: matrix gappy proper orthogonal decomposition and reduced-basis sparsification. Our results for a parameterized truss-structure problem demonstrate the practical importance of preserving Lagrangian structure and illustrate the proposed method's merits: it reduces computation time while maintaining high accuracy and stability, in contrast to existing nonlinear model-reduction techniques that do not preserve structure.« less

Preserving Lagrangian Structure in Nonlinear Model Reduction with Application to Structural Dynamics

DOE Office of Scientific and Technical Information (OSTI.GOV)

Carlberg, Kevin; Tuminaro, Ray; Boggs, Paul

Our work proposes a model-reduction methodology that preserves Lagrangian structure and achieves computational efficiency in the presence of high-order nonlinearities and arbitrary parameter dependence. As such, the resulting reduced-order model retains key properties such as energy conservation and symplectic time-evolution maps. We focus on parameterized simple mechanical systems subjected to Rayleigh damping and external forces, and consider an application to nonlinear structural dynamics. To preserve structure, the method first approximates the system's “Lagrangian ingredients''---the Riemannian metric, the potential-energy function, the dissipation function, and the external force---and subsequently derives reduced-order equations of motion by applying the (forced) Euler--Lagrange equation with thesemore » quantities. Moreover, from the algebraic perspective, key contributions include two efficient techniques for approximating parameterized reduced matrices while preserving symmetry and positive definiteness: matrix gappy proper orthogonal decomposition and reduced-basis sparsification. Our results for a parameterized truss-structure problem demonstrate the practical importance of preserving Lagrangian structure and illustrate the proposed method's merits: it reduces computation time while maintaining high accuracy and stability, in contrast to existing nonlinear model-reduction techniques that do not preserve structure.« less

Performance investigation on dissipative dielectric elastomer generators with a triangular energy harvesting scheme

NASA Astrophysics Data System (ADS)

Fan, Peng; Chen, Hualing; Li, Bo; Wang, Yongquan

2017-11-01

In this letter, a theoretical framework describing an energy harvesting cycle including the loss of tension (LT) process is proposed to investigate the energy harvesting performance of a dielectric elastomer generator (DEG) with a triangular energy harvesting scheme by considering material viscosity and leakage current. As the external force that is applied to the membrane decreases, the membrane is relaxed. When the external force decreases to zero, the condition is known as LT. Then the membrane undergoing LT can further relax, which is referred to as the LT process. The LT process is usually ignored in theoretical analysis but observed from energy harvesting experiments of DEGs. It is also studied how shrinking time and transfer capacitor affect the energy conversion of a DEG. The results indicate that energy density and conversion efficiency can be simultaneously improved by choosing appropriate shrinking time and transfer capacitor to optimize the energy harvesting cycle. The results and methods are expected to provide guidelines for the optimal design and assessment of DEGs.

Load apparatus and method for bolt-loaded compact tension test specimen

DOEpatents

Buescher, B.J. Jr.; Lloyd, W.R.; Ward, M.B.; Epstein, J.S.

1997-02-04

A bolt-loaded compact tension test specimen load apparatus includes: (a) a body having first and second opposing longitudinal ends, the first end comprising an externally threaded portion sized to be threadedly received within the test specimen threaded opening; (b) a longitudinal loading rod having first and second opposing longitudinal ends, the loading rod being slidably received in a longitudinal direction within the body internally through the externally threaded portion and slidably extending longitudinally outward of the body first longitudinal end; (c) a force sensitive transducer slidably received within the body and positioned to engage relative to the loading rod second longitudinal end; and (d) a loading bolt threadedly received relative to the body, the loading bolt having a bearing end surface and being positioned to bear against the transducer to forcibly sandwich the transducer between the loading bolt and loading rod. Also disclosed is a method of in situ determining applied force during crack propagation in a bolt-loaded compact tension test specimen. 6 figs.

Load apparatus and method for bolt-loaded compact tension test specimen

DOEpatents

Buescher, Jr., Brent J.; Lloyd, W. Randolph; Ward, Michael B.; Epstein, Jonathan S.

1997-01-01

A bolt-loaded compact tension test specimen load apparatus includes: a) a body having first and second opposing longitudinal ends, the first end comprising an externally threaded portion sized to be threadedly received within the test specimen threaded opening; b) a longitudinal loading rod having first and second opposing longitudinal ends, the loading rod being slidably received in a longitudinal direction within the body internally through the externally threaded portion and slidably extending longitudinally outward of the body first longitudinal end; c) a force sensitive transducer slidably received within the body and positioned to engage relative to the loading rod second longitudinal end; and d) a loading bolt threadedly received relative to the body, the loading bolt having a bearing end surface and being positioned to bear against the transducer to forcibly sandwich the transducer between the loading bolt and loading rod. Also disclosed is a method of in situ determining applied force during crack propagation in a bolt-loaded compact tension test specimen.

Thermally tailored gradient topography surface on elastomeric thin films.

PubMed

Roy, Sudeshna; Bhandaru, Nandini; Das, Ritopa; Harikrishnan, G; Mukherjee, Rabibrata

2014-05-14

We report a simple method for creating a nanopatterned surface with continuous variation in feature height on an elastomeric thin film. The technique is based on imprinting the surface of a film of thermo-curable elastomer (Sylgard 184), which has continuous variation in cross-linking density introduced by means of differential heating. This results in variation of viscoelasticity across the length of the surface and the film exhibits differential partial relaxation after imprinting with a flexible stamp and subjecting it to an externally applied stress for a transient duration. An intrinsic perfect negative replica of the stamp pattern is initially created over the entire film surface as long as the external force remains active. After the external force is withdrawn, there is partial relaxation of the applied stresses, which is manifested as reduction in amplitude of the imprinted features. Due to the spatial viscoelasticity gradient, the extent of stress relaxation induced feature height reduction varies across the length of the film (L), resulting in a surface with a gradient topography with progressively varying feature heights (hF). The steepness of the gradient can be controlled by varying the temperature gradient as well as the duration of precuring of the film prior to imprinting. The method has also been utilized for fabricating wettability gradient surfaces using a high aspect ratio biomimetic stamp. The use of a flexible stamp allows the technique to be extended for creating a gradient topography on nonplanar surfaces as well. We also show that the gradient surfaces with regular structures can be used in combinatorial studies related to pattern directed dewetting.

Contractive tension force stack actuator based on soft dielectric EAP

NASA Astrophysics Data System (ADS)

Kovacs, Gabor; Düring, Lukas

2009-03-01

Among the electronic polymers EAPs especially the dielectric elastomers are functional materials that have promising potential as muscle-like actuators due to their inherent compliancy and good overall performance. The combination of huge active deformations, high energy densities, good efficiencies and fast response is unique to dielectric elastomers. Furthermore, they are lightweight, have a simple structure and can be easily tailored to various applications. Up to now most scientific research work has been focused on the planar expanding actuation mode due to the fact that the commercially available acrylic material VHB 4910 (3M) can easily be processed to planar actuators and has demonstrated very high actuation performance when pre-strained. Many different actuator designs have been developed and tested which expands in plane when voltage is applied and shrinks back as soon as the applied charges are removed from the electrodes. Obviously the contractive operation mode at activation is required for a wide range of application. Due to the principle of operation of soft DE EAP, mainly two directions to performed work against external loads are possible. Beside of the commonly used expanding actuation in planar direction the contractile actuation in thickness direction of the DE film represents a very promising option in the multilayer configuration. First approaches have been presented by the folded actuator design and by the multilayer tactile display device. In this study a novel approach for active structures driven by soft dielectric EAP is presented, which can perform contractive displacements at external tensile load. The device is composed of an array of equal segments, where the dielectric films are arranged in a pile-up configuration. In order to maintain satisfying structural integrity when external tension load is applied special attention was paid to the compliant electrode design which takes a central importance concerning the force transmission capability between each layer of the actuator. Due to the stack configuration of the actuator the commonly used and pre-strained acrylic film was replaced by the stress-free IPN modified acrylic film in order to eliminate the need for external pre-strain-supporting structures. Introductorily, the specific problems on conventional expanding actuators are discussed and the aims for contractive tension force actuators are specified. Then some structural design parameters are addressed in order to achieve a high rate of yield and reliable working principle. In the main part of the study the manufacturing process of the actuators and some measurement results and experiences are discussed in detail.

Diffusion in the special theory of relativity.

PubMed

Herrmann, Joachim

2009-11-01

The Markovian diffusion theory is generalized within the framework of the special theory of relativity. Since the velocity space in relativity is a hyperboloid, the mathematical stochastic calculus on Riemanian manifolds can be applied but adopted here to the velocity space. A generalized Langevin equation in the fiber space of position, velocity, and orthonormal velocity frames is defined from which the generalized relativistic Kramers equation in the phase space in external force fields is derived. The obtained diffusion equation is invariant under Lorentz transformations and its stationary solution is given by the Jüttner distribution. Besides, a nonstationary analytical solution is derived for the example of force-free relativistic diffusion.

Large Electric Field-Enhanced-Hardness Effect in a SiO2 Film

NASA Astrophysics Data System (ADS)

Revilla, Reynier I.; Li, Xiao-Jun; Yang, Yan-Lian; Wang, Chen

2014-03-01

Silicon dioxide films are extensively used in nano and micro-electromechanical systems. Here we studied the influence of an external electric field on the mechanical properties of a SiO2 film by using nanoindentation technique of atomic force microscopy (AFM) and friction force microscopy (FFM). A giant augmentation of the relative elastic modulus was observed by increasing the localized electric field. A slight decrease in friction coefficients was also clearly observed by using FFM with the increase of applied tip voltage. The reduction of the friction coefficients is consistent with the great enhancement of sample hardness by considering the indentation-induced deformation during the friction measurements.

A simple mechanism for measuring and adjusting distraction forces during maxillary advancement.

PubMed

Suzuki, Eduardo Yugo; Suzuki, Boonsiva

2009-10-01

Direct measurement of distraction forces on the craniofacial skeleton has never been reported. The present report describes the development of a method of assessing and adjusting traction forces applied through maxillary distraction osteogenesis. A simple mechanism to measure and adjust tension force during maxillary distraction osteogenesis was developed and connected bilaterally to the traction screws of a rigid external distraction device. Measurements were carried out before and after activation using a Shimpo (Nidec-Shimpo America Corporation, Itasca, IL) force gauge in 4 patients (2 with unilateral cleft lip and/or palate, 1 with bilateral cleft lip and palate, and 1 with noncleft) during the distraction process. Activation was performed twice a day at a rate of 1 mm/day. The average maximum force applied throughout the distraction period was 42.5 N (range 16.4 to 65.3 N), with increments, after activation, averaging 10.5 N (range 7.9 to 15.7 N). In patients with unilateral cleft lip and/or palate, distraction forces on the larger segment were 65.1% higher than on the lesser segment. A differential pattern of forces was also observed in the patients with asymmetric noncleft. However, the differential forces between lateral segments were not observed in the patient with bilateral cleft lip and palate. During the activation period, distraction forces progressively increased, whereas the amount of maxillary movement decreased. Pain and discomfort were reported with high forces. Through this mechanism, direct measurement and adjustment of distraction forces during maxillary advancement was possible. The unbalanced pattern of forces observed in patients with cleft suggests the necessity of individual adjustments for controlling pain and clinical symptoms. Accordingly, assessment of distraction forces during maxillary distraction osteogenesis is extremely helpful in understanding the biomechanics of the distraction process.

Designing a Poly (N-isopropylacrylamide) Nanocapsule for Magnetic Field-assisted Drug Delivery

NASA Astrophysics Data System (ADS)

Denmark, Daniel; Mukherjee, Pritish; Witanachchi, Sarath

2014-03-01

The method of synthesis and the characteristics of polymer based nanocapsules as biomedical drug delivery systems are presented. Magnetic iron oxide nanoparticles have been incorporated into these capsules for effective guidance with external magnetic fields to transport therapeutic compounds to various parts of the human body. Once they have reached their destination they can be stimulated to release the drug to the target tissue through externally applied fields. The polymeric material that constitutes the capsules is specifically designed to melt away with the external stimuli to deliver the therapeutic bio agents near the target tissue. In this work we use nebulization to create aqueous poly (N-isopropylacrylamide) nanoparticles that decompose after being heated beyond their transition temperature. Transmission Electron Microscopic imaging (TEM) and dynamic light scattering (DLS) experiments have been conducted to study the decomposition of the capsules under external stimuli. Distribution of the magnetic nanoparticles within the capsules and their role in delivering the bio agents have been investigated by the Magnetic Force Microscopy (MFM).

Effects of load on ground reaction force and lower limb kinematics during concentric squats.

PubMed

Kellis, Eleftherios; Arambatzi, Fotini; Papadopoulos, Christos

2005-10-01

The purpose of this study was to examine the effects of external load on vertical ground reaction force, and linear and angular kinematics, during squats. Eight males aged 22.1 +/- 0.8 years performed maximal concentric squats using loads ranging from 7 to 70% of one-repetition maximum on a force plate while linear barbell velocity and the angular kinematics of the hip, knee and ankle were recorded. Maximum, average and angle-specific values were recorded. The ground reaction force ranged from 1.67 +/- 0.20 to 3.21 +/- 0.29 times body weight and increased significantly as external load increased (P < 0.05). Bar linear velocity ranged from 0.54 +/- 0.11 to 2.50 +/- 0.50 m x s(-1) and decreased significantly with increasing external load (P < 0.05). Hip, knee and ankle angles at maximum ground reaction force were affected by external load (P < 0.05). The force-barbell velocity curves were fitted using linear models with coefficients (r2) ranging from 0.59 to 0.96. The results suggest that maximal force exertion during squat exercises is not achieved at the same position of the lower body as external load is increased. In contrast, joint velocity coordination does not change as load is increased. The force-velocity relationship was linear and independent from the set of data used for its determination.

Dynamic inversion enables external magnets to concentrate ferromagnetic rods to a central target.

PubMed

Nacev, A; Weinberg, I N; Stepanov, P Y; Kupfer, S; Mair, L O; Urdaneta, M G; Shimoji, M; Fricke, S T; Shapiro, B

2015-01-14

The ability to use magnets external to the body to focus therapy to deep tissue targets has remained an elusive goal in magnetic drug targeting. Researchers have hitherto been able to manipulate magnetic nanotherapeutics in vivo with nearby magnets but have remained unable to focus these therapies to targets deep within the body using magnets external to the body. One of the factors that has made focusing of therapy to central targets between magnets challenging is Samuel Earnshaw's theorem as applied to Maxwell's equations. These mathematical formulations imply that external static magnets cannot create a stable potential energy well between them. We posited that fast magnetic pulses could act on ferromagnetic rods before they could realign with the magnetic field. Mathematically, this is equivalent to reversing the sign of the potential energy term in Earnshaw's theorem, thus enabling a quasi-static stable trap between magnets. With in vitro experiments, we demonstrated that quick, shaped magnetic pulses can be successfully used to create inward pointing magnetic forces that, on average, enable external magnets to concentrate ferromagnetic rods to a central location.

Influence of Diamondlike Carbon Coating of Screws on Axial Tightening Force and Stress Distribution on Overdenture Bar Frameworks with Different Fit Levels and Materials.

PubMed

dos Santos, Mateus Bertolini Fernandes; Bacchi, Atais; Consani, Rafael Leonardo Xediek; Correr-Sobrinho, Lourenço

2015-01-01

The aim of this study was to evaluate the axial tightening force applied by conventional and diamondlike carbon (DLC)-coated screws and to verify, through three-dimensional finite element analysis (FEA), the stress distribution caused by different framework materials and prosthetic screws in overdenture frameworks with different misfit levels. The axial tightening force applied by the screw was evaluated by means of a titanium matrix connected to a load cell. Conventional titanium or DLC-coated screws were tightened with a digital torque wrench, and the load values were recorded. The values were applied in an FEA to a bar-clip attachment system connected to two 4.0 × 11-mm external-hexagon titanium implants placed in an anterior edentulous arch. DLC-coated and conventional screws were modeled with their respective axial forces obtained on the experimental evaluation for three bar framework materials (titanium, nickel-chromium, and cobalt-chromium) and three levels of misfit (100, 150, and 200 μm). Von Mises stresses for prosthetic components and maximum principal stress and microstrains (maximum principal strains) for bone tissue were measured. The mean force applied by the conventional screw was 25.55 N (± 1.78); the prosthetic screw coated with a DLC layer applied a mean force of 31.44 N (± 2.11), a statistically significant difference. In the FEA, the DLC screw led to higher stresses on the framework; however, the prosthetic screw suffered lower stress. No influence of screw type was seen in the bone tissue. Titanium frameworks reduced the stress transmitted to the bone tissue and the bar framework but had no influence on the screws. Higher misfit values resulted in an increased stress/strain in bone tissue and bar framework, which was not the case for retention screws.

External kinetics of the kettlebell snatch in amateur lifters

PubMed Central

Wilson, Cameron J.; Lorenzen, Christian

2017-01-01

Background Kettlebell lifting has gained increased popularity as both a form of resistance training and as a sport, despite the paucity of literature validating its use as a training tool. Kettlebell sport requires participants to complete the kettlebell snatch continuously over prolonged periods of time. Kettlebell sport and weightlifting involve similar exercises, however, their traditional uses suggest they are better suited to training different fitness qualities. This study examined the three-dimensional ground reaction force (GRF) and force applied to the kettlebell over a 6 min kettlebell snatch set in 12 kettlebell-trained males. Methods During this set, VICON was used to record the kettlebell trajectory with nine infrared cameras while the GRF of each leg was recorded with a separate AMTI force plate. Over the course of the set, an average of 13.9 ± 3.3 repetitions per minute were performed with a 24 kg kettlebell. Significance was evaluated with a two-way ANOVA and paired t-tests, whilst Cohen’s F (ESF) and Cohen’s D (ESD) were used to determine the magnitude. Results The applied force at the point of maximum acceleration was 814 ± 75 N and 885 ± 86 N for the downwards and upwards phases, respectively. The absolute peak resultant bilateral GRF was 1,746 ± 217 N and 1,768 ± 242 N for the downwards and upwards phases, respectively. Bilateral GRF of the first and last 14 repetitions was found to be similar, however there was a significant difference in the peak applied force (F (1.11) = 7.42, p = 0.02, ESF = 0.45). Unilateral GRF was found have a significant difference for the absolute anterior–posterior (F (1.11) = 885.15, p < 0.0001, ESF = 7) and medio-lateral force vectors (F (1.11) = 5.31, p = 0.042, ESF = 0.67). Discussion Over the course of a single repetition there were significant differences in the GRF and applied force at multiple points of the kettlebells trajectory. The kettlebell snatch loads each leg differently throughout a repetition and performing the kettlebell snatch for 6 min will result in a reduction in peak applied force. PMID:28367368

External kinetics of the kettlebell snatch in amateur lifters.

PubMed

Ross, James A; Keogh, Justin W L; Wilson, Cameron J; Lorenzen, Christian

2017-01-01

Kettlebell lifting has gained increased popularity as both a form of resistance training and as a sport, despite the paucity of literature validating its use as a training tool. Kettlebell sport requires participants to complete the kettlebell snatch continuously over prolonged periods of time. Kettlebell sport and weightlifting involve similar exercises, however, their traditional uses suggest they are better suited to training different fitness qualities. This study examined the three-dimensional ground reaction force (GRF) and force applied to the kettlebell over a 6 min kettlebell snatch set in 12 kettlebell-trained males. During this set, VICON was used to record the kettlebell trajectory with nine infrared cameras while the GRF of each leg was recorded with a separate AMTI force plate. Over the course of the set, an average of 13.9 ± 3.3 repetitions per minute were performed with a 24 kg kettlebell. Significance was evaluated with a two-way ANOVA and paired t -tests, whilst Cohen's F (ESF) and Cohen's D (ESD) were used to determine the magnitude. The applied force at the point of maximum acceleration was 814 ± 75 N and 885 ± 86 N for the downwards and upwards phases, respectively. The absolute peak resultant bilateral GRF was 1,746 ± 217 N and 1,768 ± 242 N for the downwards and upwards phases, respectively. Bilateral GRF of the first and last 14 repetitions was found to be similar, however there was a significant difference in the peak applied force ( F (1.11) = 7.42, p = 0.02, ESF = 0.45). Unilateral GRF was found have a significant difference for the absolute anterior-posterior ( F (1.11) = 885.15, p < 0.0001, ESF = 7) and medio-lateral force vectors ( F (1.11) = 5.31, p = 0.042, ESF = 0.67). Over the course of a single repetition there were significant differences in the GRF and applied force at multiple points of the kettlebells trajectory. The kettlebell snatch loads each leg differently throughout a repetition and performing the kettlebell snatch for 6 min will result in a reduction in peak applied force.

Particles with nonlinear electric response: Suppressing van der Waals forces by an external field.

PubMed

Soo, Heino; Dean, David S; Krüger, Matthias

2017-01-01

We study the classical thermal component of Casimir, or van der Waals, forces between point particles with highly anharmonic dipole Hamiltonians when they are subjected to an external electric field. Using a model for which the individual dipole moments saturate in a strong field (a model that mimics the charges in a neutral, perfectly conducting sphere), we find that the resulting Casimir force depends strongly on the strength of the field, as demonstrated by analytical results. For a certain angle between the external field and center-to-center axis, the fluctuation force can be tuned and suppressed to arbitrarily small values. We compare the forces between these particles with those between particles with harmonic Hamiltonians and also provide a simple formula for asymptotically large external fields, which we expect to be generally valid for the case of saturating dipole moments.

Stability of aerosol droplets in Bessel beam optical traps under constant and pulsed external forces

DOE Office of Scientific and Technical Information (OSTI.GOV)

David, Grégory; Esat, Kıvanç; Hartweg, Sebastian

We report on the dynamics of aerosol droplets in optical traps under the influence of additional constant and pulsed external forces. Experimental results are compared with simulations of the three-dimensional droplet dynamics for two types of optical traps, the counter-propagating Bessel beam (CPBB) trap and the quadruple Bessel beam (QBB) trap. Under the influence of a constant gas flow (constant external force), the QBB trap is found to be more stable compared with the CPBB trap. By contrast, under pulsed laser excitation with laser pulse durations of nanoseconds (pulsed external force), the type of trap is of minor importance formore » the droplet stability. It typically needs pulsed laser forces that are several orders of magnitude higher than the optical forces to induce escape of the droplet from the trap. If the droplet strongly absorbs the pulsed laser light, these escape forces can be strongly reduced. The lower stability of absorbing droplets is a result of secondary thermal processes that cause droplet escape.« less

Casimir force phase transitions in the graphene family

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rodriguez-Lopez, Pablo; Kort-Kamp, Wilton J. M.; Dalvit, Diego A. R.

The Casimir force is a universal interaction induced by electromagnetic quantum fluctuations between any types of objects. We found that the expansion of the graphene family by adding silicene, germanene and stanene (2D allotropes of Si, Ge, and Sn), lends itself as a platform to probe Dirac-like physics in honeycomb staggered systems in such a ubiquitous interaction. Here, we discover Casimir force phase transitions between these staggered 2D materials induced by the complex interplay between Dirac physics, spin-orbit coupling and externally applied fields. Particularly, we find that the interaction energy experiences different power law distance decays, magnitudes and dependences onmore » characteristic physical constants. Furthermore, due to the topological properties of these materials, repulsive and quantized Casimir interactions become possible.« less

A Stochastic Version of the Noether Theorem

NASA Astrophysics Data System (ADS)

González Lezcano, Alfredo; Cabo Montes de Oca, Alejandro

2018-06-01

A stochastic version of the Noether theorem is derived for systems under the action of external random forces. The concept of moment generating functional is employed to describe the symmetry of the stochastic forces. The theorem is applied to two kinds of random covariant forces. One of them generated in an electrodynamic way and the other is defined in the rest frame of the particle as a function of the proper time. For both of them, it is shown the conservation of the mean value of a random drift momentum. The validity of the theorem makes clear that random systems can produce causal stochastic correlations between two faraway separated systems, that had interacted in the past. In addition possible connections of the discussion with the Ives Couder's experimental results are remarked.

Casimir force phase transitions in the graphene family

DOE PAGES

Rodriguez-Lopez, Pablo; Kort-Kamp, Wilton J. M.; Dalvit, Diego A. R.; ...

2017-03-15

The Casimir force is a universal interaction induced by electromagnetic quantum fluctuations between any types of objects. We found that the expansion of the graphene family by adding silicene, germanene and stanene (2D allotropes of Si, Ge, and Sn), lends itself as a platform to probe Dirac-like physics in honeycomb staggered systems in such a ubiquitous interaction. Here, we discover Casimir force phase transitions between these staggered 2D materials induced by the complex interplay between Dirac physics, spin-orbit coupling and externally applied fields. Particularly, we find that the interaction energy experiences different power law distance decays, magnitudes and dependences onmore » characteristic physical constants. Furthermore, due to the topological properties of these materials, repulsive and quantized Casimir interactions become possible.« less

Development of a two-dimensional skin friction balance nulling circuit using multivariable control theory

NASA Technical Reports Server (NTRS)

Tripp, John S.; Patek, Stephen D.

1988-01-01

Measurement of planar skin friction forces in aerodynamic testing currently requires installation of two perpendicularly mounted, single-axis balances; consequently, force components must be sensed at two distinct locations. A two-axis instrument developed at the Langley Research Center to overcome this disadvantage allows measurement of a two-dimensional force at one location. This paper describes a feedback-controlled nulling circuit developed for the NASA two-axis balance which, without external compensation, is inherently unstable because of its low friction mechanical design. Linear multivariable control theory is applied to an experimentally validated mathematical model of the balance to synthesize a state-variable feedback control law. Pole placement techniques and computer simulation studies are employed to select eigenvalues which provide ideal transient response with decoupled sensing dynamics.

Mechanically induced alterations in cultured skeletal muscle growth

NASA Technical Reports Server (NTRS)

Vandenburgh, H. H.; Hatfaludy, S.; Karlisch, P.; Shansky, J.

1991-01-01

Model systems are available for mechanically stimulating cultured skeletal muscle cells by passive tensile forces which simulate those found in vivo. When applied to embryonic muscle cells in vitro these forces induce tissue organogenesis, metabolic adaptations, and muscle cell growth. The mechanical stimulation of muscle cell growth correlates with stretch-induced increases in the efflux of prostaglandins PGE2 and PGF2(alpha) in a time and frequency dependent manner. These prostaglandins act as mechanical 'second messengers' regulating skeletal muscle protein turnover rates. Since they also effect bone remodelling in response to tissue loading and unloading, secreted prostaglandins may serve as paracrine growth factors, coordinating the growth rates of muscle and bone in response to external mechanical forces. Cell culture model systems will supplement other models in understanding mechanical transduction processes at the molecular level.

Passive microrheology of soft materials with atomic force microscopy: A wavelet-based spectral analysis

DOE Office of Scientific and Technical Information (OSTI.GOV)

Martinez-Torres, C.; Streppa, L.; Arneodo, A.

2016-01-18

Compared to active microrheology where a known force or modulation is periodically imposed to a soft material, passive microrheology relies on the spectral analysis of the spontaneous motion of tracers inherent or external to the material. Passive microrheology studies of soft or living materials with atomic force microscopy (AFM) cantilever tips are rather rare because, in the spectral densities, the rheological response of the materials is hardly distinguishable from other sources of random or periodic perturbations. To circumvent this difficulty, we propose here a wavelet-based decomposition of AFM cantilever tip fluctuations and we show that when applying this multi-scale methodmore » to soft polymer layers and to living myoblasts, the structural damping exponents of these soft materials can be retrieved.« less

Model-Based Heterogeneous Data Fusion for Reliable Force Estimation in Dynamic Structures under Uncertainties

PubMed Central

Khodabandeloo, Babak; Melvin, Dyan; Jo, Hongki

2017-01-01

Direct measurements of external forces acting on a structure are infeasible in many cases. The Augmented Kalman Filter (AKF) has several attractive features that can be utilized to solve the inverse problem of identifying applied forces, as it requires the dynamic model and the measured responses of structure at only a few locations. But, the AKF intrinsically suffers from numerical instabilities when accelerations, which are the most common response measurements in structural dynamics, are the only measured responses. Although displacement measurements can be used to overcome the instability issue, the absolute displacement measurements are challenging and expensive for full-scale dynamic structures. In this paper, a reliable model-based data fusion approach to reconstruct dynamic forces applied to structures using heterogeneous structural measurements (i.e., strains and accelerations) in combination with AKF is investigated. The way of incorporating multi-sensor measurements in the AKF is formulated. Then the formulation is implemented and validated through numerical examples considering possible uncertainties in numerical modeling and sensor measurement. A planar truss example was chosen to clearly explain the formulation, while the method and formulation are applicable to other structures as well. PMID:29149088

New force replica exchange method and protein folding pathways probed by force-clamp technique.

PubMed

Kouza, Maksim; Hu, Chin-Kun; Li, Mai Suan

2008-01-28

We have developed a new extended replica exchange method to study thermodynamics of a system in the presence of external force. Our idea is based on the exchange between different force replicas to accelerate the equilibrium process. This new approach was applied to obtain the force-temperature phase diagram and other thermodynamical quantities of the three-domain ubiquitin. Using the C(alpha)-Go model and the Langevin dynamics, we have shown that the refolding pathways of single ubiquitin depend on which terminus is fixed. If the N end is fixed then the folding pathways are different compared to the case when both termini are free, but fixing the C terminal does not change them. Surprisingly, we have found that the anchoring terminal does not affect the pathways of individual secondary structures of three-domain ubiquitin, indicating the important role of the multidomain construction. Therefore, force-clamp experiments, in which one end of a protein is kept fixed, can probe the refolding pathways of a single free-end ubiquitin if one uses either the polyubiquitin or a single domain with the C terminus anchored. However, it is shown that anchoring one end does not affect refolding pathways of the titin domain I27, and the force-clamp spectroscopy is always capable to predict folding sequencing of this protein. We have obtained the reasonable estimate for unfolding barrier of ubiquitin, using the microscopic theory for the dependence of unfolding time on the external force. The linkage between residue Lys48 and the C terminal of ubiquitin is found to have the dramatic effect on the location of the transition state along the end-to-end distance reaction coordinate, but the multidomain construction leaves the transition state almost unchanged. We have found that the maximum force in the force-extension profile from constant velocity force pulling simulations depends on temperature nonlinearly. However, for some narrow temperature interval this dependence becomes linear, as have been observed in recent experiments.

Magnetic field sensor based on the Ampere's force using dual-polarization DBR fiber laser

NASA Astrophysics Data System (ADS)

Yao, Shuang; Zhang, Yang; Guan, Baiou

2015-08-01

A novel magnetic field sensor using distributed Bragg reflector (DBR) fiber laser by Ampere's force effect is proposed and experimentally demonstrated. The key sensing element, that is the dual-polarization DBR fiber laser, is fixed on the middle part of two copper plates which carry the current. Ampere's force is applied onto the coppers due to an external magnetic field generated by a DC solenoid. Thus, the lateral force from the coppers is converted to a corresponding beat frequency signal shift produced by the DBR laser. The electric current sensing is also realized by the same configuration and same principle simultaneously in an intuitive manner. Good agreement between the theory calculation and the experimental results is obtained, which shows a good linearity. This sensor's sensitivity to the magnetic field and to the electric current finally reaches ~258.92 kHz/mT and ~1.08727 MHz/A, respectively.

External Load Affects Ground Reaction Force Parameters Non-uniformly during Running in Weightlessness

NASA Technical Reports Server (NTRS)

DeWitt, John; Schaffner, Grant; Laughlin, Mitzi; Loehr, James; Hagan, R. Donald

2004-01-01

Long-term exposure to microgravity induces detrimefits to the musculcskdetal system (Schneider et al., 1995; LeBlanc et al., 2000). Treadmill exercise is used onboard the International Space Station as an exercise countermeasure to musculoskeletal deconditioning due to spaceflight. During locomotive exercise in weightlessness (0G), crewmembers wear a harness attached to an external loading mechanism (EL). The EL pulls the crewmember toward the treadmill, and provides resistive load during the impact and propulsive phases of gait. The resulting forces may be important in stimulating bone maintenance (Turner, 1998). The EL can be applied via a bungee and carabineer clip configuration attached to the harness and can be manipulated to create varying amounts of load levels during exercise. Ground-based research performed using a vertically mounted treadmill found that peak ground reaction forces (GRF) during running at an EL of less than one body weight (BW) are less than those that occur during running in normal gravity (1G) (Davis et al., 1996). However, it is not known how the GRF are affected by the EL in a true OG environment. Locomotion while suspended may result in biomechanics that differ from free running. The purpose of this investigation was to determine how EL affects peak impact force, peak propulsive force, loading rate, and impulse of the GRF during running in 0G. It was hypothesized that increasing EL would result in increases in each GRF parameter.

Irrelevance of the Power Stroke for the Directionality, Stopping Force, and Optimal Efficiency of Chemically Driven Molecular Machines

PubMed Central

Astumian, R. Dean

2015-01-01

A simple model for a chemically driven molecular walker shows that the elastic energy stored by the molecule and released during the conformational change known as the power-stroke (i.e., the free-energy difference between the pre- and post-power-stroke states) is irrelevant for determining the directionality, stopping force, and efficiency of the motor. Further, the apportionment of the dependence on the externally applied force between the forward and reverse rate constants of the power-stroke (or indeed among all rate constants) is irrelevant for determining the directionality, stopping force, and efficiency of the motor. Arguments based on the principle of microscopic reversibility demonstrate that this result is general for all chemically driven molecular machines, and even more broadly that the relative energies of the states of the motor have no role in determining the directionality, stopping force, or optimal efficiency of the machine. Instead, the directionality, stopping force, and optimal efficiency are determined solely by the relative heights of the energy barriers between the states. Molecular recognition—the ability of a molecular machine to discriminate between substrate and product depending on the state of the machine—is far more important for determining the intrinsic directionality and thermodynamics of chemo-mechanical coupling than are the details of the internal mechanical conformational motions of the machine. In contrast to the conclusions for chemical driving, a power-stroke is very important for the directionality and efficiency of light-driven molecular machines and for molecular machines driven by external modulation of thermodynamic parameters. PMID:25606678

Formation of Organized Protein Thin Films with External Electric Field.

PubMed

Ferreira, Cecília Fabiana da G; Camargo, Paulo C; Benelli, Elaine M

2015-10-01

The effect of an external electric field on the formation of protein GlnB-Hs films and on its buffer solution on siliconized glass slides has been analyzed by current versus electric field curves and atomic force microscopy (AFM). The Herbaspirillum seropedicae GlnB protein (GlnB-Hs) is a globular, soluble homotrimer (36 kDa) with its 3-D structure previously determined. Concentrations of 10 nM native denatured GlnB-Hs protein were deposited on siliconized glass slides under ambient conditions. Immediately after solution deposition a maximum electric field of 30 kV/m was applied with rates of 3 V/s. The measured currents were surface currents and were analyzed as transport current. Electric current started to flow only after a minimum electric field (critical value) for the systems analyzed. The AFM images showed films with a high degree of directional organization only when the proteins were present in the solution. These results showed that the applied electric field favored directional organization of the protein GlnB-Hs films and may contribute to understand the formation of protein films under applied electric fields.

Effect of cyclical forces on the periodontal ligament and alveolar bone remodeling during orthodontic tooth movement

PubMed Central

Kalajzic, Zana; Peluso, Elizabeth Blake; Utreja, Achint; Dyment, Nathaniel; Nihara, Jun; Xu, Manshan; Chen, Jing; Uribe, Flavio; Wadhwa, Sunil

2014-01-01

Objective To investigate the effect of externally applied cyclical (vibratory) forces on the rate of tooth movement, the structural integrity of the periodontal ligament, and alveolar bone remodeling. Methods Twenty-six female Sprague-Dawley rats (7 weeks old) were divided into four groups: CTRL (unloaded), VBO (molars receiving a vibratory stimulus only), TMO (molars receiving an orthodontic spring only), and TMO+VB (molars receiving an orthodontic spring and the additional vibratory stimulus). In TMO and TMO+VB groups, the rat first molars were moved mesially for 2 weeks using Nickel-Titanium coil spring delivering 25 g of force. In VBO and TMO+VB groups, cyclical forces at 0.4 N and 30 Hz were applied occlusally twice a week for 10 minutes. Microfocus X-ray computed tomography analysis and tooth movement measurements were performed on the dissected rat maxillae. Tartrate-resistant acid phosphatase staining and collagen fiber assessment were performed on histological sections. Results Cyclical forces significantly inhibited the amount of tooth movement. Histological analysis showed marked disorganization of the collagen fibril structure of the periodontal ligament during tooth movement. Tooth movement caused a significant increase in osteoclast parameters on the compression side of alveolar bone and a significant decrease in bone volume fraction in the molar region compared to controls. Conclusions Tooth movement was significantly inhibited by application of cyclical forces. PMID:23937517

A Development of Force Plate for Biomechanics Analysis of Standing and Walking

NASA Astrophysics Data System (ADS)

Wardoyo, S.; Hutajulu, P. T.; Togibasa, O.

2016-08-01

Force plates are known as an excellent teaching aid to demonstrate the kinematics and dynamics of motion and commonly used in biomechanics laboratories to measure ground forces involved in the motion of human. It is consist of a metal plate with sensors attached to give an electrical output proportional to the force on the plate. Moreover, force plates are useful for examining the kinetic characteristics of an athlete's movement. They provide information about the external forces involved in movement that can aid a coach or sports scientist to quantitatively evaluate the athlete's skill development. In this study, we develop our prototype of force plate with less than 100,- simply by using flexible force transducer attached inside rubber matt, in the form of square blocks (dimension: 250 mm × 150 mm × 10 mm), with maximum load up to 60 kg. The handmade force plate was tested by applying biomechanics analysis for standing and walking. The testing was done on Experimental Soccer Courses’ students at the Department of Physical Education, Health and Recreation, University of Cenderawasih. The design of the force plate system together with biomechanics analysis will be discussed.

Direct numerical simulation of the effect of an electric field on flame stability

DOE Office of Scientific and Technical Information (OSTI.GOV)

Belhi, Memdouh; Domingo, Pascale; Vervisch, Pierre

2010-12-15

The role of electric fields in stabilising combustion is a well-known phenomenon. Among the possible mechanisms favouring the anchorage of the flame base, the ion-driven wind acting directly on flow momentum ahead of the flame base could be the leading one. Direct numerical simulation has been used to verify this hypothesis and lead to a better understanding of diffusion flame base anchoring in the presence of an externally applied voltage. In this context, a simplified modelling approach is proposed to describe combustion in the presence of electric body forces. The model reproduces the tendencies of experimental observations found in themore » literature. The sensitivity of the flame lift-off height to the applied voltage is studied and the modification of the velocity field ahead of the flame base induced by the electric volume forces is highlighted. (author)« less

Continuous particle separation using pressure-driven flow-induced miniaturizing free-flow electrophoresis (PDF-induced μ-FFE).

PubMed

Jeon, Hyungkook; Kim, Youngkyu; Lim, Geunbae

2016-01-28

In this paper, we introduce pressure-driven flow-induced miniaturizing free-flow electrophoresis (PDF-induced μ-FFE), a novel continuous separation method. In our separation system, the external flow and electric field are applied to particles, such that particle movement is affected by pressure-driven flow, electroosmosis, and electrophoresis. We then analyzed the hydrodynamic drag force and electrophoretic force applied to the particles in opposite directions. Based on this analysis, micro- and nano-sized particles were separated according to their electrophoretic mobilities with high separation efficiency. Because the separation can be achieved in a simple T-shaped microchannel, without the use of internal electrodes, it offers the advantages of low-cost, simple device fabrication and bubble-free operation, compared with conventional μ-FFE methods. Therefore, we expect the proposed separation method to have a wide range of filtering/separation applications in biochemical analysis.

Micro/nano-mechanical test system employing tensile test holder with push-to-pull transformer

DOEpatents

Oh, Yunje; Cyrankowski, Edward; Shan, Zhiwei; Asif, Syed Amanula Syed

2013-05-07

A micromachined or microelectromechanical system (MEMS) based push-to-pull mechanical transformer for tensile testing of micro-to-nanometer scale material samples including a first structure and a second structure. The second structure is coupled to the first structure by at least one flexible element that enables the second structure to be moveable relative to the first structure, wherein the second structure is disposed relative to the first structure so as to form a pulling gap between the first and second structures such that when an external pushing force is applied to and pushes the second structure in a tensile extension direction a width of the pulling gap increases so as to apply a tensile force to a test sample mounted across the pulling gap between a first sample mounting area on the first structure and a second sample mounting area on the second structure.

Micro/nano-mechanical test system employing tensile test holder with push-to-pull transformer

DOEpatents

Oh, Yunje; Cyrankowski, Edward; Shan, Zhiwei; Syed Asif, Syed Amanula

2014-07-29

A micromachined or microelectromechanical system (MEMS) based push-to-pull mechanical transformer for tensile testing of micro-to-nanometer scale material samples including a first structure and a second structure. The second structure is coupled to the first structure by at least one flexible element that enables the second structure to be moveable relative to the first structure, wherein the second structure is disposed relative to the first structure so as to form a pulling gap between the first and second structures such that when an external pushing force is applied to and pushes the second structure in a tensile extension direction a width of the pulling gap increases so as to apply a tensile force to a test sample mounted across the pulling gap between a first sample mounting area on the first structure and a second sample mounting area on the second structure.

Continuous particle separation using pressure-driven flow-induced miniaturizing free-flow electrophoresis (PDF-induced μ-FFE)

PubMed Central

Jeon, Hyungkook; Kim, Youngkyu; Lim, Geunbae

2016-01-01

In this paper, we introduce pressure-driven flow-induced miniaturizing free-flow electrophoresis (PDF-induced μ-FFE), a novel continuous separation method. In our separation system, the external flow and electric field are applied to particles, such that particle movement is affected by pressure-driven flow, electroosmosis, and electrophoresis. We then analyzed the hydrodynamic drag force and electrophoretic force applied to the particles in opposite directions. Based on this analysis, micro- and nano-sized particles were separated according to their electrophoretic mobilities with high separation efficiency. Because the separation can be achieved in a simple T-shaped microchannel, without the use of internal electrodes, it offers the advantages of low-cost, simple device fabrication and bubble-free operation, compared with conventional μ-FFE methods. Therefore, we expect the proposed separation method to have a wide range of filtering/separation applications in biochemical analysis. PMID:26819221

Multimodal chemo-magnetic control of self-propelling microbots

NASA Astrophysics Data System (ADS)

Singh, Amit Kumar; Dey, Krishna Kanti; Chattopadhyay, Arun; Mandal, Tapas Kumar; Bandyopadhyay, Dipankar

2014-01-01

We report a controlled migration of an iron nanoparticle (FeNP) coated polymer micromotor. The otherwise diffusive motion of the motor was meticulously directed through an in situ pH-gradient and an external magnetic field. The self-propulsion owing to the asymmetric catalytic decomposition of peroxide fuel was directed through a pH gradient imposed across the motor-surface, while the magnetic field induced an external control on the movement and the speed of the motor. Interestingly, the sole influence of the pH gradient could move the motor as high as ~25 body lengths per second, which was further magnified by the external assistance from the magnetic field. Applying a magnetic field against the pH directed motion helped in the quantitative experimental estimation of the force-field required to arrest the chemotactic migration. The influence of the coupled internal and external fields could halt, steer or reverse the direction the motor inside a microchannel, rotate the motor around a target, and deliver the motor to a cluster of cells. This study showcases a multimodal chemical-magnetic field regulated migration of micro-machines for sensing, transport, and delivery inside a fluidic environment.We report a controlled migration of an iron nanoparticle (FeNP) coated polymer micromotor. The otherwise diffusive motion of the motor was meticulously directed through an in situ pH-gradient and an external magnetic field. The self-propulsion owing to the asymmetric catalytic decomposition of peroxide fuel was directed through a pH gradient imposed across the motor-surface, while the magnetic field induced an external control on the movement and the speed of the motor. Interestingly, the sole influence of the pH gradient could move the motor as high as ~25 body lengths per second, which was further magnified by the external assistance from the magnetic field. Applying a magnetic field against the pH directed motion helped in the quantitative experimental estimation of the force-field required to arrest the chemotactic migration. The influence of the coupled internal and external fields could halt, steer or reverse the direction the motor inside a microchannel, rotate the motor around a target, and deliver the motor to a cluster of cells. This study showcases a multimodal chemical-magnetic field regulated migration of micro-machines for sensing, transport, and delivery inside a fluidic environment. Electronic supplementary information (ESI) available: Scanning electron microscopy, transmission electron microscopy, X-ray diffraction pattern, vibrating sample magnetometry (VSM) hysteresis loop of freshly prepared FeNP coated micromotor and movies of micromotor motion. See DOI: 10.1039/c3nr05294j

Static response of coated microbubbles compressed between rigid plates: Simulations and asymptotic analysis including elastic and adhesive forces

NASA Astrophysics Data System (ADS)

Lytra, A.; Pelekasis, N.

2018-03-01

The static response of coated microbubbles is investigated with a novel approach employed for modeling contact between a microbubble and the cantilever of an atomic force microscope. Elastic tensions and moments are described via appropriate constitutive laws. The encapsulated gas is assumed to undergo isothermal variations. Due to the hydrophilic nature of the cantilever, an ultrathin aqueous film is formed, which transfers the force onto the shell. An interaction potential describes the local pressure applied on the shell. The problem is solved in axisymmetric form with the finite element method. The response is governed by the dimensionless bending, k^ b=kb/(χ R02 ), pressure, P^ A=(PAR0 )/χ , and interaction potential, W ^ =w0/χ . Hard polymeric shells have negligible resistance to gas compression, while for the softer lipid shells gas compressibility is comparable with shell elasticity. As the external force increases, numerical simulations reveal that the force versus deformation (f vs d) curve of polymeric shells exhibits a transition from the linear O(d) (Reissner) regime, marked by flattened shapes around the contact region, to a non-linear O(d1/2) (Pogorelov) regime dominated by shapes exhibiting crater formation due to buckling. When lipid shells are tested, buckling is bypassed as the external force increases and flattened shapes prevail in an initially linear f vs d curve. Transition to a curved upwards regime is observed as the force increases, where gas compression and area dilatation form the dominant balance providing a nonlinear regime with an O(d3) dependence. Asymptotic analysis recovers the above patterns and facilitates estimation of the shell mechanical properties.

Muscle activity response to external moment during single-leg drop landing in young basketball players: the importance of biceps femoris in reducing internal rotation of knee during landing.

PubMed

Fujii, Meguru; Sato, Haruhiko; Takahira, Naonobu

2012-01-01

Internal tibial rotation with the knee close to full extension combined with valgus collapse during drop landing generally results in non-contact anterior cruciate ligament (ACL) injury. The purpose of this study was to investigate the relationship between internal rotation of the knee and muscle activity from internal and external rotator muscles, and between the internal rotation of knee and externally applied loads on the knee during landing in collegiate basketball players. Our hypothesis was that the activity of biceps femoris muscle would be an important factor reducing internal knee rotation during landing. The subjects were 10 collegiate basketball students: 5 females and 5 males. The subjects performed a single-leg drop landing from a 25-cm height. Femoral and tibial kinematics were measured using a 3D optoelectronic tracking system during the drop landings, and then the knee angular motions were determined. Ground reaction forces and muscle activation patterns (lateral hamstring and medial hamstring) were simultaneously measured and computed. Results indicated that lower peak internal tibial rotation angle at the time of landing was associated with greater lateral hamstring activity (r = -0.623, p < 0.001). When gender was considered, the statistically significant correlation remained only in females. There was no association between the peak internal tibial rotation angle and the knee internal rotation moment. Control of muscle activity in the lateral to medial hamstring would be an important factor in generating sufficient force to inhibit excessive internal rotation during landing. Strengthening the biceps femoris might mitigate the higher incidence of non-contact ACL injury in female athletes. Key pointsLower activity of the external rotator muscle of the knee, which inhibits internal rotation of the knee, may be the reason why females tend to show a large internal rotation of the knee during drop landing.Externally applied internal rotation moment of the knee during landing would not be expected to explain why female athletes tend to show excessive internal knee rotation.Biceps femoris strength training might help decrease the incidence of non-contact ACL injury in female athletes.

Unexpected mechanochemical complexity in the mechanistic scenarios of disulfide bond reduction in alkaline solution

NASA Astrophysics Data System (ADS)

Dopieralski, Przemyslaw; Ribas-Arino, Jordi; Anjukandi, Padmesh; Krupicka, Martin; Marx, Dominik

2017-02-01

The reduction of disulfides has a broad importance in chemistry, biochemistry and materials science, particularly those methods that use mechanochemical activation. Here we show, using isotensional simulations, that strikingly different mechanisms govern disulfide cleavage depending on the external force. Desolvation and resolvation processes are found to be crucial, as they have a direct impact on activation free energies. The preferred pathway at moderate forces, a bimolecular SN2 attack of OH- at sulfur, competes with unimolecular C-S bond rupture at about 2 nN, and the latter even becomes barrierless at greater applied forces. Moreover, our study unveils a surprisingly rich reactivity scenario that also includes the transformation of concerted SN2 reactions into pure bond-breaking processes at specific forces. Given that these forces are easily reached in experiments, these insights will fundamentally change our understanding of mechanochemical activation in general, which is now expected to be considerably more intricate than previously thought.

The footprint of the inter-decadal Pacific oscillation in Indian Ocean sea surface temperatures

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dong, Lu; Zhou, Tianjun; Dai, Aiguo

Superimposed on a pronounced warming trend, the Indian Ocean (IO) sea surface temperatures (SSTs) also show considerable decadal variations that can cause regional climate oscillations around the IO. However, the mechanisms of the IO decadal variability remain unclear. Here we perform numerical experiments using a state-of-the-art, fully coupled climate model in which the external forcings with or without the observed SSTs in the tropical eastern Pacific Ocean (TEP) are applied for 1871–2012. Both the observed timing and magnitude of the IO decadal variations are well reproduced in those experiments with the TEP SSTs prescribed to observations. Although the external forcingsmore » account for most of the warming trend, the decadal variability in IO SSTs is dominated by internal variability that is induced by the TEP SSTs, especially the Inter-decadal Pacific Oscillation (IPO). The IPO weakens (enhances) the warming of the external forcings by about 50% over the IO during IPO’s cold (warm) phase, which contributes about 10% to the recent global warming hiatus since 1999. As a result, the decadal variability in IO SSTs is modulated by the IPO-induced atmospheric adjustment through changing surface heat fluxes, sea surface height and thermocline depth.« less

The footprint of the inter-decadal Pacific oscillation in Indian Ocean sea surface temperatures

DOE PAGES

Dong, Lu; Zhou, Tianjun; Dai, Aiguo; ...

2016-02-17

Superimposed on a pronounced warming trend, the Indian Ocean (IO) sea surface temperatures (SSTs) also show considerable decadal variations that can cause regional climate oscillations around the IO. However, the mechanisms of the IO decadal variability remain unclear. Here we perform numerical experiments using a state-of-the-art, fully coupled climate model in which the external forcings with or without the observed SSTs in the tropical eastern Pacific Ocean (TEP) are applied for 1871–2012. Both the observed timing and magnitude of the IO decadal variations are well reproduced in those experiments with the TEP SSTs prescribed to observations. Although the external forcingsmore » account for most of the warming trend, the decadal variability in IO SSTs is dominated by internal variability that is induced by the TEP SSTs, especially the Inter-decadal Pacific Oscillation (IPO). The IPO weakens (enhances) the warming of the external forcings by about 50% over the IO during IPO’s cold (warm) phase, which contributes about 10% to the recent global warming hiatus since 1999. As a result, the decadal variability in IO SSTs is modulated by the IPO-induced atmospheric adjustment through changing surface heat fluxes, sea surface height and thermocline depth.« less

External Forces Affecting Higher Education. NACUBO Professional File. Vol. 7, No. 5.

ERIC Educational Resources Information Center

Bailey, Stephen K.

Out of the many external forces that influence college campuses, there are four that have had (or are likely to have) a major impact on the fortunes of higher education. The ways in which college and university officials and friends react to these forces can make an enormous difference to the future of higher education. The forces are: (1) Federal…

Revealing bending and force in a soft body through a plant root inspired approach

PubMed Central

Lucarotti, Chiara; Totaro, Massimo; Sadeghi, Ali; Mazzolai, Barbara; Beccai, Lucia

2015-01-01

An emerging challenge in soft robotics research is to reveal mechanical solicitations in a soft body. Nature provides amazing clues to develop unconventional components that are capable of compliant interactions with the environment and living beings, avoiding mechanical and algorithmic complexity of robotic design. We inspire from plant-root mechanoperception and develop a strategy able to reveal bending and applied force in a soft body with only two sensing elements of the same kind, and a null computational effort. The stretching processes that lead to opposite tissue deformations on the two sides of the root wall are emulated with two tactile sensing elements, made of soft and stretchable materials, which conform to reversible changes in the shape of the body they are built in and follow its deformations. Comparing the two sensory responses, we can discriminate the concave and the convex side of the bent body. Hence, we propose a new strategy to reveal in a soft body the maximum bending angle (or the maximum deflection) and the externally applied force according to the body's mechanical configuration. PMID:25739743

Using the two-way shape memory effect of NiTi to control surface texture for cellular mechanotransduction

NASA Astrophysics Data System (ADS)

Liang, Yuan; Qin, Haifeng; Hou, Xiaoning; Doll, Gary L.; Ye, Chang; Dong, Yalin

2018-07-01

Mechanical force can crucially affect form and function of cells, and play critical roles in many diseases. While techniques to conveniently apply mechanical force to cells are limited, we fabricate a surface actuator prototype for cellular mechanotransduction by imparting severe plastic deformation into the surface of shape memory alloy (SMA). Using ultrasonic nanocrystal surface modification (UNSM), a deformation-based surface engineering technique with high controllability, micro surface patterns can be generated on the surface of SMA so that the micro-size cell can conform to the pattern; meanwhile, phase transformation can be induced in the subsurface by severe plastic deformation. By controlling plastic deformation and phase transformation, it is possible to establish a quantitative relation between deformation and temperature. When cells are cultured on the UNSM-treated surface, such surface can dynamically deform in response to external temperature change, and therefore apply controllable mechanical force to cells. Through this study, we demonstrate a novel way to fabricate a low-cost surface actuator that has the potential to be used for high-throughput cellular mechanotransduction.

Anharmonic 1D actuator model including electrostatic and Casimir forces with fractional damping perturbed by an external force

NASA Astrophysics Data System (ADS)

Mansoori Kermani, Maryam; Dehestani, Maryam

2018-06-01

We modeled a one-dimensional actuator including the Casimir and electrostatic forces perturbed by an external force with fractional damping. The movable electrode was assumed to oscillate by an anharmonic elastic force originated from Murrell-Mottram or Lippincott potential. The nonlinear equations have been solved via the Adomian decomposition method. The behavior of the displacement of the electrode from equilibrium position, its velocity and acceleration were described versus time. Also, the changes of the displacement have been investigated according to the frequency of the external force and the voltage of the electrostatic force. The convergence of the Adomian method and the effect of the orders of expansion on the displacement versus time, frequency, and voltage were discussed. The pull-in parameter was obtained and compared with the other models in the literature. This parameter was described versus the equilibrium position and anharmonicity constant.

Anharmonic 1D actuator model including electrostatic and Casimir forces with fractional damping perturbed by an external force

NASA Astrophysics Data System (ADS)

Mansoori Kermani, Maryam; Dehestani, Maryam

2018-03-01

We modeled a one-dimensional actuator including the Casimir and electrostatic forces perturbed by an external force with fractional damping. The movable electrode was assumed to oscillate by an anharmonic elastic force originated from Murrell-Mottram or Lippincott potential. The nonlinear equations have been solved via the Adomian decomposition method. The behavior of the displacement of the electrode from equilibrium position, its velocity and acceleration were described versus time. Also, the changes of the displacement have been investigated according to the frequency of the external force and the voltage of the electrostatic force. The convergence of the Adomian method and the effect of the orders of expansion on the displacement versus time, frequency, and voltage were discussed. The pull-in parameter was obtained and compared with the other models in the literature. This parameter was described versus the equilibrium position and anharmonicity constant.

The mechanical forces in katydid sound production

NASA Astrophysics Data System (ADS)

Xiao, Huaping; Chiu, Cheng-Wei; Zhou, Yan; He, Xingliang; Epstein, Ben; Liang, Hong

2013-10-01

Katydids and crickets generate their characteristic calling sound by rubbing their wings together. The mechanisms of the rubbing force, however, have not been extensively studied. The change of mechanical force with external parameters (speed and applied load) in the stridulation process has not been reported. Our current study aims to investigate the mechanical forces of katydid stridulation. Four pairs of files and plectrums from a katydid, which are responsible for the katydid's sound production, were examined with a specially designed experimental configuration. Due to the asymmetric nature of the wing motion in their opening and closing, the contact between the plectrum and file resembles that of a ratchet. Multiple frequencies were generated during experimental wing rubbing so that a calling-like sound was produced. Results showed that the morphology of the plectrum/file contact has significant effects on mechanical forces induced on the wings and resulting sound production. The roles of the mechanical forces include sound generation, tone modification, and energy consumption. The findings in this work reveal the variation trend of mechanical force with sliding speed and applied load. The frequency and amplitude of the sound wave produced in tribo-test are close to those in natural condition. By mimicking the microstructure of the plectrum and file teeth, acoustic instruments with high mechanical energy conversion rate can be developed. Our results provide new approaches in the design and improvement of micro-machines for acoustic applications, as well as in hybrid robotic systems.

Diffusion of Brownian particles in a tilted periodic potential under the influence of an external Ornstein-Uhlenbeck noise

NASA Astrophysics Data System (ADS)

Bai, Zhan-Wu; Zhang, Wei

2018-01-01

The diffusion behaviors of Brownian particles in a tilted periodic potential under the influence of an internal white noise and an external Ornstein-Uhlenbeck noise are investigated through numerical simulation. In contrast to the case when the bias force is smaller or absent, the diffusion coefficient exhibits a nonmonotonic dependence on the correlation time of the external noise when bias force is large. A mechanism different from locked-to-running transition theory is presented for the diffusion enhancement by a bias force in intermediate to large damping. In the underdamped regime and the presence of external noise, the diffusion coefficient is a monotonically decreasing function of low temperature rather than a nonmonotonic function when external noise is absent. The diffusive process undergoes four regimes when bias force approaches but is less than its critical value and noises intensities are small. These behaviors can be attributed to the locked-to-running transition of particles.

Mechanical Stress Induces Remodeling of Vascular Networks in Growing Leaves

PubMed Central

Bar-Sinai, Yohai; Julien, Jean-Daniel; Sharon, Eran; Armon, Shahaf; Nakayama, Naomi; Adda-Bedia, Mokhtar; Boudaoud, Arezki

2016-01-01

Differentiation into well-defined patterns and tissue growth are recognized as key processes in organismal development. However, it is unclear whether patterns are passively, homogeneously dilated by growth or whether they remodel during tissue expansion. Leaf vascular networks are well-fitted to investigate this issue, since leaves are approximately two-dimensional and grow manyfold in size. Here we study experimentally and computationally how vein patterns affect growth. We first model the growing vasculature as a network of viscoelastic rods and consider its response to external mechanical stress. We use the so-called texture tensor to quantify the local network geometry and reveal that growth is heterogeneous, resembling non-affine deformations in composite materials. We then apply mechanical forces to growing leaves after veins have differentiated, which respond by anisotropic growth and reorientation of the network in the direction of external stress. External mechanical stress appears to make growth more homogeneous, in contrast with the model with viscoelastic rods. However, we reconcile the model with experimental data by incorporating randomness in rod thickness and a threshold in the rod growth law, making the rods viscoelastoplastic. Altogether, we show that the higher stiffness of veins leads to their reorientation along external forces, along with a reduction in growth heterogeneity. This process may lead to the reinforcement of leaves against mechanical stress. More generally, our work contributes to a framework whereby growth and patterns are coordinated through the differences in mechanical properties between cell types. PMID:27074136

Numerical and experimental study of the effect of the induced electric potential in Lorentz force velocimetry

NASA Astrophysics Data System (ADS)

Hernández, Daniel; Boeck, Thomas; Karcher, Christian; Wondrak, Thomas

2018-01-01

Lorentz force velocimetry (LFV) is a contactless velocity measurement technique for electrically conducting fluids. When a liquid metal or a molten glass flows through an externally applied magnetic field, eddy currents and a flow-braking force are generated inside the liquid. This force is proportional to the velocity or flow rate of the fluid and, due to Newton’s third law, a force of the same magnitude but in opposite direction acts on the source of the applied magnetic field which in our case are permanent magnets. According to Ohm’s law for moving conductors at low magnetic Reynolds numbers, an electric potential is induced which ensures charge conservation. In this paper, we analyze the contribution of the induced electric potential to the total Lorentz force by considering two different scenarios: conducting walls of finite thickness and aspect ratio variation of the cross-section of the flow. In both the cases, the force component generated by the electric potential is always in the opposite direction to the total Lorentz force. This force component is sensitive to the electric boundary conditions of the flow of which insulating and perfectly conducting walls are the two limiting cases. In the latter case, the overall electric resistance of the system is minimized, resulting in a considerable increase in the measured Lorentz force. Additionally, this force originating from the electric potential also decays when the aspect ratio of the cross-section of the flow is changed. Hence, the sensitivity of the measurement technique is enhanced by either increasing wall conductivity or optimizing the aspect ratio of the cross-section of the flow.

Force adaptation transfers to untrained workspace regions in children: evidence for developing inverse dynamic motor models.

PubMed

Jansen-Osmann, Petra; Richter, Stefanie; Konczak, Jürgen; Kalveram, Karl-Theodor

2002-03-01

When humans perform goal-directed arm movements under the influence of an external damping force, they learn to adapt to these external dynamics. After removal of the external force field, they reveal kinematic aftereffects that are indicative of a neural controller that still compensates the no longer existing force. Such behavior suggests that the adult human nervous system uses a neural representation of inverse arm dynamics to control upper-extremity motion. Central to the notion of an inverse dynamic model (IDM) is that learning generalizes. Consequently, aftereffects should be observable even in untrained workspace regions. Adults have shown such behavior, but the ontogenetic development of this process remains unclear. This study examines the adaptive behavior of children and investigates whether learning a force field in one hemifield of the right arm workspace has an effect on force adaptation in the other hemifield. Thirty children (aged 6-10 years) and ten adults performed 30 degrees elbow flexion movements under two conditions of external damping (negative and null). We found that learning to compensate an external damping force transferred to the opposite hemifield, which indicates that a model of the limb dynamics rather than an association of visited space and experienced force was acquired. Aftereffects were more pronounced in the younger children and readaptation to a null-force condition was prolonged. This finding is consistent with the view that IDMs in children are imprecise neural representations of the actual arm dynamics. It indicates that the acquisition of IDMs is a developmental achievement and that the human motor system is inherently flexible enough to adapt to any novel force within the limits of the organism's biomechanics.

Radiation reaction on a classical charged particle: a modified form of the equation of motion.

PubMed

Alcaine, Guillermo García; Llanes-Estrada, Felipe J

2013-09-01

We present and numerically solve a modified form of the equation of motion for a charged particle under the influence of an external force, taking into account the radiation reaction. This covariant equation is integro-differential, as Dirac-Röhrlich's, but has several technical improvements. First, the equation has the form of Newton's second law, with acceleration isolated on the left hand side and the force depending only on positions and velocities: Thus, the equation is linear in the highest derivative. Second, the total four-force is by construction perpendicular to the four-velocity. Third, if the external force vanishes for all future times, the total force and the acceleration automatically vanish at the present time. We show the advantages of this equation by solving it numerically for several examples of external force.

Radiation reaction on a classical charged particle: A modified form of the equation of motion

NASA Astrophysics Data System (ADS)

Alcaine, Guillermo García; Llanes-Estrada, Felipe J.

2013-09-01

We present and numerically solve a modified form of the equation of motion for a charged particle under the influence of an external force, taking into account the radiation reaction. This covariant equation is integro-differential, as Dirac-Röhrlich's, but has several technical improvements. First, the equation has the form of Newton's second law, with acceleration isolated on the left hand side and the force depending only on positions and velocities: Thus, the equation is linear in the highest derivative. Second, the total four-force is by construction perpendicular to the four-velocity. Third, if the external force vanishes for all future times, the total force and the acceleration automatically vanish at the present time. We show the advantages of this equation by solving it numerically for several examples of external force.

Effect of the External Lubrication Method for a Rotary Tablet Press on the Adhesion of the Film Coating Layer.

PubMed

Kondo, Hisami; Toyota, Hiroyasu; Kamiya, Takayuki; Yamashita, Kazunari; Hakomori, Tadashi; Imoto, Junko; Kimura, Shin-Ichiro; Iwao, Yasunori; Itai, Shigeru

2017-01-01

External lubrication is a useful method which reduces the adhesion of powder to punches and dies by spraying lubricants during the tableting process. However, no information is available on whether the tablets prepared using an external lubrication system can be applicable for a film coating process. In this study, we evaluated the adhesion force of the film coating layer to the surface of tablets prepared using an external lubrication method, compared with those prepared using internal lubrication method. We also evaluated wettability, roughness and lubricant distribution state on the tablet surface before film coating, and investigated the relationship between peeling of the film coating layer and these tablet surface properties. Increasing lubrication through the external lubrication method decreased wettability of the tablet surface. However, no change was observed in the adhesion force of the film coating layer. On the other hand, increasing lubrication through the internal lubrication method, decreased both wettability of the tablet surface and the adhesion force of the film coating layer. The magnesium stearate distribution state on the tablet surface was assessed using an X-ray fluorescent analyzer and lubricant agglomerates were observed in the case of the internal lubrication method. However, the lubricant was uniformly dispersed in the external lubrication samples. These results indicate that the distribution state of the lubricant affects the adhesion force of the film coating layer, and external lubrication maintained sufficient lubricity and adhesion force of the film coating layer with a small amount of lubricant.

Dynamics of static friction between steel and silicon

PubMed Central

Yang, Zhiping; Zhang, H. P.; Marder, M.

2008-01-01

We conducted experiments in which steel and silicon or quartz are clamped together. Even with the smallest tangential forces we could apply, we always found reproducible sliding motions on the nanometer scale. The velocities we study are thousands of times smaller than in previous investigations. The samples first slide and then lock up even when external forces hold steady. One might call the result “slip-stick” friction. We account for the results with a phenomenological theory that results from considering the rate and state theory of dynamic friction at low velocities. Our measurements lead us to set the instantaneous coefficient of static friction that normally enters rate and state theories to zero. PMID:18768792

Large Electric Field–Enhanced–Hardness Effect in a SiO2 Film

PubMed Central

Revilla, Reynier I.; Li, Xiao-Jun; Yang, Yan-Lian; Wang, Chen

2014-01-01

Silicon dioxide films are extensively used in nano and micro–electromechanical systems. Here we studied the influence of an external electric field on the mechanical properties of a SiO2 film by using nanoindentation technique of atomic force microscopy (AFM) and friction force microscopy (FFM). A giant augmentation of the relative elastic modulus was observed by increasing the localized electric field. A slight decrease in friction coefficients was also clearly observed by using FFM with the increase of applied tip voltage. The reduction of the friction coefficients is consistent with the great enhancement of sample hardness by considering the indentation–induced deformation during the friction measurements. PMID:24681517

Stability of magnetohydrodynamic Dean Flow as applied to centrifugally confined plasmas

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hassam, A.B.

1999-10-01

Dean Flow is the azimuthal flow of fluid between static concentric cylinders. In a magnetized plasma, there may also be radial stratification of the pressure. The ideal magnetohydrodynamic stability of such a flow in the presence of a strong axial magnetic field and an added radial gravitational force is examined. It is shown that both the Kelvin{endash}Helmholtz instability and pressure-gradient-driven interchanges can be stabilized if the flow is driven by a unidirectional external force and if the plasma annulus is sufficiently thin (large aspect ratio). These results find application in schemes using centrifugal confinement of plasma for fusion. {copyright} {italmore » 1999 American Institute of Physics.}« less

On the origin of why static or breakloose friction is larger than kinetic friction, and how to reduce it: the role of aging, elasticity and sequential interfacial slip.

PubMed

Lorenz, B; Persson, B N J

2012-06-06

We discuss the origin of static friction and show how it can be reduced towards kinetic friction by the appropriate design of the sliding system. The basic idea is to use elastically soft solids and apply the external forces in such a way that different parts of the contacting interface start to slip at different times during the (tangential) loading process. In addition, the local slip must be large enough in order to result in a strong drop in the static friction force. We illustrate the theoretical predictions with the results of a simple model experiment.

Spatially Synchronous Extinction of Species under External Forcing

NASA Astrophysics Data System (ADS)

Amritkar, R. E.; Rangarajan, Govindan

2006-06-01

More than 99% of the species that ever existed on the surface of the Earth are now extinct and their extinction on a global scale has been a puzzle. One may think that a species under an external threat may survive in some isolated locations leading to the revival of the species. Using a general model we show that, under a common external forcing, the species with a quadratic saturation term first undergoes spatial synchronization and then extinction. The effect can be observed even when the external forcing acts only on some locations provided the dynamics contains a synchronizing term. Absence of the quadratic saturation term can help the species to avoid extinction.

Viscosity of confined two-dimensional Yukawa liquids: A nonequilibrium method

DOE Office of Scientific and Technical Information (OSTI.GOV)

Landmann, S.; Kählert, H.; Thomsen, H.

2015-09-15

We present a nonequilibrium method that allows one to determine the viscosity of two-dimensional dust clusters in an isotropic confinement. By applying a tangential external force to the outer parts of the cluster (e.g., with lasers), a sheared velocity profile is created. The decay of the angular velocity towards the center of the confinement potential is determined by a balance between internal (viscosity) and external friction (neutral gas damping). The viscosity can then be calculated from a fit of the measured velocity profile to a solution of the Navier-Stokes equation. Langevin dynamics simulations are used to demonstrate the feasibility ofmore » the method. We find good agreement of the measured viscosity with previous results for macroscopic Yukawa plasmas.« less

Correlation between the knee adduction torque and medial contact force for a variety of gait patterns.

PubMed

Zhao, Dong; Banks, Scott A; Mitchell, Kim H; D'Lima, Darryl D; Colwell, Clifford W; Fregly, Benjamin J

2007-06-01

The external knee adduction torque has been proposed as a surrogate measure for medial compartment load during gait. However, a direct link between these two quantities has not been demonstrated using in vivo measurement of medial compartment load. This study uses in vivo data collected from a single subject with an instrumented knee implant to evaluate this link. The subject performed five different overground gait motions (normal, fast, slow, wide, and toe-out) with simultaneous collection of instrumented implant, video motion, and ground reaction data. For each trial, the knee adduction torque was measured externally while the total axial force applied to the tibial insert was measured internally. Based on data collected from the same subject performing treadmill gait under fluoroscopic motion analysis, a regression equation was developed to calculate medial contact force from the implant load cell measurements. Correlation analyses were performed for the stance phase and entire gait cycle to quantify the relationship between the knee adduction torque and both the medial contact force and the medial to total contact force ratio. When the entire gait cycle was analyzed, R(2) for medial contact force was 0.77 when all gait trials were analyzed together and between 0.69 and 0.93 when each gait trial was analyzed separately (p < 0.001 in all cases). For medial to total force ratio, R(2) was 0.69 for all trials together and between 0.54 and 0.90 for each trial separately (p < 0.001 in all cases). When only the stance phase was analyzed, R(2) values were slightly lower. These results support the hypothesis that the knee adduction torque is highly correlated with medial compartment contact force and medial to total force ratio during gait. (c) 2007 Orthopaedic Research Society. Published by Wiley Periodicals, Inc.

Statistical analysis of sperm sorting

NASA Astrophysics Data System (ADS)

Koh, James; Marcos, Marcos

2017-11-01

The success rate of assisted reproduction depends on the proportion of morphologically normal sperm. It is possible to use an external field for manipulation and sorting. Depending on their morphology, the extent of response varies. Due to the wide distribution in sperm morphology even among individuals, the resulting distribution of kinematic behaviour, and consequently the feasibility of sorting, should be analysed statistically. In this theoretical work, Resistive Force Theory and Slender Body Theory will be applied and compared. Full name is Marcos.

Coupling of demixing and magnetic ordering phase transitions probed by turbidimetric measurements in a binary mixture doped with magnetic nanoparticles.

PubMed

Hernández-Díaz, Lorenzo; Hernández-Reta, Juan Carlos; Encinas, Armando; Nahmad-Molinari, Yuri

2010-05-19

We present a novel study on the effect of a magnetic field applied on a binary mixture doped with magnetic nanoparticles close to its demixing transition. Turbidity measurements in the Faraday configuration show that the effect of applying an external field produces changes in the critical opalescence of the mixture that allow us to track an aggregation produced by critical Casimir forces and a reversible aggregation due to the formation of chain-like flocks in response to the external magnetic field. The observation of a crossover of the aggregation curves through optical signals is interpreted as the evolution from low to high power dispersion nuclei due to an increase in the radius of the condensation seed brought about by Casimir or magnetic interactions. Finally, evidence of an enhanced magnetocaloric effect due to the coupling between mixing and ordering phase transitions is presented which opens up a nonsolid state approach of designing refrigerating cycles and devices.

Force reduction induced by unidirectional transversal muscle loading is independent of local pressure.

PubMed

Siebert, Tobias; Rode, Christian; Till, Olaf; Stutzig, Norman; Blickhan, Reinhard

2016-05-03

Transversal unidirectional compression applied to muscles via external loading affects muscle contraction dynamics in the longitudinal direction. A recent study reported decreasing longitudinal muscle forces with increasing transversal load applied with a constant contact area (i.e., leading to a simultaneous increase in local pressure). To shed light on these results, we examine whether the decrease in longitudinal force depends on the load, the local pressure, or both. To this end, we perform isometric experiments on rat M. gastrocnemius medialis without and with transversal loading (i) changing the local pressure from 1.1-3.2Ncm(-2) (n=9) at a constant transversal load (1.62N) and (ii) increasing the transversal load (1.15-3.45N) at a constant local pressure of 2.3Ncm(-2) (n=7). While we did not note changes in the decrease in longitudinal muscle force in the first experiment, the second experiment resulted in an almost-linear reduction of longitudinal force between 7.5±0.6% and 14.1±1.7%. We conclude that the observed longitudinal force reduction is not induced by local effects such as malfunction of single muscle compartments, but that similar internal stress conditions and myofilament configurations occur when the local pressure changes given a constant load. The decreased longitudinal force may be explained by increased internal pressure and a deformed myofilament lattice that is likely associated with the decomposition of cross-bridge forces on the one hand and the inhibition of cross-bridges on the other hand. Copyright © 2016 Elsevier Ltd. All rights reserved.

Conditions for Destabilizing Pickering emulsions using external electric fields

NASA Astrophysics Data System (ADS)

Hwang, Kyuho; Singh, Pushpendra; Aubry, Nadine

2009-11-01

Fine particles are readily adsorbed at fluid-fluid interfaces, and can be used as stabilizers in emulsion technology by preventing adjacent drops from coalescing with each other. We investigate a new technique to destabilize such emulsions, or Pickering emulsions, by applying an external electric field. Experiments show that the latter has two effects: (i) the drops elongate in the direction of the electric field, (ii) the local particle density varies on the drop surface due to the dielectrophoretic (DEP) force acting on the particles. It is shown that the latter is the dominant factor in the destabilization process. Particularly, the success of the method depends on the values of certain dimensionless parameters; specifically, the ratio of the work done by the dielectrophoretic force must be larger than the work done by the buoyant force. Moreover, drops do not coalesce through the regions where the particles locally cluster, whether those are gathered at the poles or at the equator of the drops. As particles move, particle-free openings form on the drop's surface, which allow for adjacent drops to merge. This process takes place even if the particles are fully packed on the drops' surfaces as particles get ejected from the clustering areas due to a buckling phenomenon.

Effect of attentional focus strategies on peak force and performance in the standing long jump.

PubMed

Wu, Will F W; Porter, Jared M; Brown, Lee E

2012-05-01

Significant benefits in standing long jump performance have been demonstrated when subjects were provided verbal instructions that promoted an external focus of attention compared with an internal focus of attention, suggesting differences in ground reaction forces. The purpose of the present study was to evaluate peak force and jump performance between internal and external focus of attention strategies. Untrained subjects were assigned to both experimental conditions in which verbal instructions were provided to promote either an external or internal focus of attention. All subjects completed a total number of 5 standing long jumps. The results of the study demonstrated that the external focus of attention condition elicited significantly greater jump distance (153.6 ± 38.6 cm) than the internal focus of attention condition (139.5 ± 46.7 cm). There were no significant differences observed between conditions in peak force (1429.8 ± 289.1 N and 1453.7 ± 299.7 N, respectively). The results add to the growing body of literature describing the training and learning benefits of an external focus of attention. Practitioners should create standardized verbal instructions using an external focus of attention to maximize standing long jump performance.

Examining the Impact of External Influences on Police Use of Deadly Force over Time.

ERIC Educational Resources Information Center

White, Michael D.

2002-01-01

Used interrupted time-series analysis (ARIMA) to study the impact of legislation and judicial intervention on the use of deadly force by police officers in Philadelphia, Pennsylvania. Findings generally suggest that dynamic changes in the internal working environment can outweigh the influence of external mechanisms on deadly force use. Findings…

Test-retest reliability of a balance testing protocol with external perturbations in young healthy adults.

PubMed

Robbins, Shawn M; Caplan, Ryan M; Aponte, Daniel I; St-Onge, Nancy

2017-10-01

External perturbations are utilized to challenge balance and mimic realistic balance threats in patient populations. The reliability of such protocols has not been established. The purpose was to examine test-retest reliability of balance testing with external perturbations. Healthy adults (n=34; mean age 23 years) underwent balance testing over two visits. Participants completed ten balance conditions in which the following parameters were combined: perturbation or non-perturbation, single or double leg, and eyes open or closed. Three trials were collected for each condition. Data were collected on a force plate and external perturbations were applied by translating the plate. Force plate center of pressure (CoP) data were summarized using 13 different CoP measures. Test-retest reliability was examined using intraclass correlation coefficients (ICC) and Bland-Altman plots. CoP measures of total speed and excursion in both anterior-posterior and medial-lateral directions generally had acceptable ICC values for perturbation conditions (ICC=0.46 to 0.87); however, many other CoP measures (e.g. range, area of ellipse) had unacceptable test-retest reliability (ICC<0.70). Improved CoP measures were present on the second visit indicating a potential learning effect. Non-perturbation conditions generally produced more reliable CoP measures than perturbation conditions during double leg standing, but not single leg standing. Therefore, changes to balance testing protocols that include external perturbations should be made to improve test-retest reliability and diminish learning including more extensive participant training and increasing the number of trials. CoP measures that consider all data points (e.g. total speed) are more reliable than those that only consider a few data points. Copyright © 2017 Elsevier B.V. All rights reserved.

Motor unit recruitment and firing rate in medial gastrocnemius muscles during external perturbations in standing in humans.

PubMed

Pollock, C L; Ivanova, T D; Hunt, M A; Garland, S J

2014-10-01

There is limited investigation of the interaction between motor unit recruitment and rate coding for modulating force during standing or responding to external perturbations. Fifty-seven motor units were recorded from the medial gastrocnemius muscle with intramuscular electrodes in response to external perturbations in standing. Anteriorly directed perturbations were generated by applying loads in 0.45-kg increments at the pelvis every 25-40 s until 2.25 kg was maintained. Motor unit firing rate was calculated for the initial recruitment load and all subsequent loads during two epochs: 1) dynamic response to perturbation directly following each load drop and 2) maintenance of steady state between perturbations. Joint kinematics and surface electromyography (EMG) from lower extremities and force platform measurements were assessed. Application of the external loads resulted in a significant forward progression of the anterior-posterior center of pressure (AP COP) that was accompanied by modest changes in joint angles (<3°). Surface EMG increased more in medial gastrocnemius than in the other recorded muscles. At initial recruitment, motor unit firing rate immediately after the load drop was significantly lower than during subsequent load drops or during the steady state at the same load. There was a modest increase in motor unit firing rate immediately after the load drop on subsequent load drops associated with regaining balance. There was no effect of maintaining balance with increased load and forward progression of the AP COP on steady-state motor unit firing rate. The medial gastrocnemius utilized primarily motor unit recruitment to achieve the increased levels of activation necessary to maintain standing in the presence of external loads. Copyright © 2014 the American Physiological Society.

Recent advances on glass-forming systems driven far from equilibrium. Special issue marking the completion of the Research Unit FOR 1394 `Nonlinear response to probe vitrification'

NASA Astrophysics Data System (ADS)

Fuchs, Matthias

2017-08-01

The nature of the glass transition is one of the frontier questions in Statistical Physics and Materials Science. Highly cooperative structural processes develop in glass-forming melts exhibiting relaxational dynamics which is spread out over many decades in time. While considerable progress has been made in recent decades towards understanding dynamical slowing-down in quiescent systems, the interplay of glassy dynamics with external fields reveals a wealth of novel phenomena yet to be explored. This special issue focuses on recent results obtained by the Research Unit FOR 1394 `Nonlinear response to probe vitrification' which was funded by the German Science Foundation (DFG). In the projects of the research unit, strong external fields were used in order to gain insights into the complex structural and transport phenomena at the glass transition under far-from-equilibrium conditions. This aimed inter alia to test theories of the glass transition developed for quiescent systems by pushing them beyond their original regime. Combining experimental, simulational, and theoretical efforts, the eight projects within the FOR 1394 measured and determined aspects of the nonlinear response of supercooled metallic, polymeric, and silica melts, of colloidal dispersions, and of ionic liquids. Applied fields included electric and mechanic fields, and forced active probing (`micro-rheology'), where a single probe is forced through the glass-forming host. Nonlinear stress-strain and force-velocity relations as well as nonlinear dielectric susceptibilities and conductivities were observed. While the physical manipulation of melts and glasses is interesting in its own right, especially technologically, the investigations performed by the FOR 1394 suggest to use the response to strong homogeneous and inhomogeneous fields as technique to explore on the microscopic level the cooperative mechanisms in dense melts of strongly interacting constituents. Questions considered concern the (de-)coupling of different dynamical degrees of freedom in an external field, and the ensuing state diagrams. What forces are required to detach a localized probe particle from its initial environment in a supercooled liquid, in a glassy or granular system? Do metallic and colloidal glasses yield homogeneously or by strain localization under differently applied stresses? Which mechanisms determine field-dependent susceptibilities in dielectric and ionically conducting glass formers?

A Bidirectional Brain-Machine Interface Algorithm That Approximates Arbitrary Force-Fields

PubMed Central

Semprini, Marianna; Mussa-Ivaldi, Ferdinando A.; Panzeri, Stefano

2014-01-01

We examine bidirectional brain-machine interfaces that control external devices in a closed loop by decoding motor cortical activity to command the device and by encoding the state of the device by delivering electrical stimuli to sensory areas. Although it is possible to design this artificial sensory-motor interaction while maintaining two independent channels of communication, here we propose a rule that closes the loop between flows of sensory and motor information in a way that approximates a desired dynamical policy expressed as a field of forces acting upon the controlled external device. We previously developed a first implementation of this approach based on linear decoding of neural activity recorded from the motor cortex into a set of forces (a force field) applied to a point mass, and on encoding of position of the point mass into patterns of electrical stimuli delivered to somatosensory areas. However, this previous algorithm had the limitation that it only worked in situations when the position-to-force map to be implemented is invertible. Here we overcome this limitation by developing a new non-linear form of the bidirectional interface that can approximate a virtually unlimited family of continuous fields. The new algorithm bases both the encoding of position information and the decoding of motor cortical activity on an explicit map between spike trains and the state space of the device computed with Multi-Dimensional-Scaling. We present a detailed computational analysis of the performance of the interface and a validation of its robustness by using synthetic neural responses in a simulated sensory-motor loop. PMID:24626393

Pulsed plasma thruster by applied a high current hollow cathode discharge

NASA Astrophysics Data System (ADS)

Watanabe, Masayuki; N. Nogera Team; T. Kamada Team

2013-09-01

The pulsed plasma thruster applied by a high current hollow cathode discharge has been investigated. In this research, the pseudo-spark discharge (PSD), which is a one of a pulsed high current hollow cathode discharge, is applied to the plasma thruster. In PSD, the opposite surfaces of the anode and cathode have a small circular hole and the cathode has a cylindrical cavity behind the circular hole. To generate the high speed plasma flow, the diameter of the anode hole is enlarged as compared with that of the cathode hole. As a result, the plasma is accelerated by a combination of an electro-magnetic force and a thermo-dynamic force inside a cathode cavity. For the improvement of the plasma jet characteristic, the magnetic field is also applied to the plasma jet. To magnetize the plasma jet, the external magnetic field is directly induced nearby the electrode holes. Consequently, the plasma jet is accelerated with the self-azimuthal magnetic field. With the magnetic field, the temperature and the density of the plasma jet were around 5 eV and in the order of 10 19 m-3. The density increased several times as compared with that without the magnetic field.

Combined Euler column vibration isolation and energy harvesting

NASA Astrophysics Data System (ADS)

Davis, R. B.; McDowell, M. D.

2017-05-01

A new device that combines vibration isolation and energy harvesting is modeled, simulated, and tested. The vibration isolating portion of the device uses post-buckled beams as its spring elements. Piezoelectric film is applied to the beams to harvest energy from their dynamic flexure. The entire device operates passively on applied base excitation and requires no external power or control system. The structural system is modeled using the elastica, and the structural response is applied as forcing on the electric circuit equation to predict the output voltage and the corresponding harvested power. The vibration isolation and energy harvesting performance is simulated across a large parameter space and the modeling approach is validated with experimental results. Experimental transmissibilities of 2% and harvested power levels of 0.36 μW are simultaneously demonstrated. Both theoretical and experimental data suggest that there is not necessarily a trade-off between vibration isolation and harvested power. That is, within the practical operational range of the device, improved vibration isolation will be accompanied by an increase in the harvested power as the forcing frequency is increased.

Tight junctions negatively regulate mechanical forces applied to adherens junctions in vertebrate epithelial tissue.

PubMed

Hatte, Guillaume; Prigent, Claude; Tassan, Jean-Pierre

2018-02-05

Epithelia are layers of polarised cells tightly bound to each other by adhesive contacts. Epithelia act as barriers between an organism and its external environment. Understanding how epithelia maintain their essential integrity while remaining sufficiently plastic to allow events such as cytokinesis to take place is a key biological problem. In vertebrates, the remodelling and reinforcement of adherens junctions maintains epithelial integrity during cytokinesis. The involvement of tight junctions in cell division, however, has remained unexplored. Here, we examine the role of tight junctions during cytokinesis in the epithelium of the Xenopus laevis embryo. Depletion of the tight junction-associated proteins ZO-1 and GEF-H1 leads to altered cytokinesis duration and contractile ring geometry. Using a tension biosensor, we show that cytokinesis defects originate from misregulation of tensile forces applied to adherens junctions. Our results reveal that tight junctions regulate mechanical tension applied to adherens junctions, which in turn impacts cytokinesis.This article has an associated First Person interview with the first author of the paper. © 2018. Published by The Company of Biologists Ltd.

Double closed-loop cascade control for lower limb exoskeleton with elastic actuation.

PubMed

Zhu, Yanhe; Zheng, Tianjiao; Jin, Hongzhe; Yang, Jixing; Zhao, Jie

2015-01-01

Unlike traditional rigid actuators, the significant features of Series Elastic Actuator (SEA) are stable torque control, lower output impedance, impact resistance and energy storage. Recently, SEA has been applied in many exoskeletons. In such applications, a key issue is how to realize the human-exoskeleton movement coordination. In this paper, double closed-loop cascade control for lower limb exoskeleton with SEA is proposed. This control method consists of inner SEA torque loop and outer contact force loop. Utilizing the SEA torque control with a motor velocity loop, actuation performances of SEA are analyzed. An integrated exoskeleton control system is designed, in which joint angles are calculated by internal encoders and resolvers and contact forces are gathered by external pressure sensors. The double closed-loop cascade control model is established based on the feedback signals of internal and external sensor. Movement experiments are accomplished in our prototype of lower limb exoskeleton. Preliminary results indicate the exoskeleton movements with pilot can be realized stably by utilizing this double closed-loop cascade control method. Feasibility of the SEA in our exoskeleton robot and effectiveness of the control method are verified.

Externally controlled on-demand release of anti-HIV drug using magneto-electric nanoparticles as carriers.

PubMed

Nair, Madhavan; Guduru, Rakesh; Liang, Ping; Hong, Jeongmin; Sagar, Vidya; Khizroev, Sakhrat

2013-01-01

Although highly active anti-retroviral therapy has resulted in remarkable decline in the morbidity and mortality in AIDS patients, inadequately low delivery of anti-retroviral drugs across the blood-brain barrier results in virus persistence. The capability of high-efficacy-targeted drug delivery and on-demand release remains a formidable task. Here we report an in vitro study to demonstrate the on-demand release of azidothymidine 5'-triphosphate, an anti-human immunodeficiency virus drug, from 30 nm CoFe2O4@BaTiO3 magneto-electric nanoparticles by applying a low alternating current magnetic field. Magneto-electric nanoparticles as field-controlled drug carriers offer a unique capability of field-triggered release after crossing the blood-brain barrier. Owing to the intrinsic magnetoelectricity, these nanoparticles can couple external magnetic fields with the electric forces in drug-carrier bonds to enable remotely controlled delivery without exploiting heat. Functional and structural integrity of the drug after the release was confirmed in in vitro experiments with human immunodeficiency virus-infected cells and through atomic force microscopy, spectrophotometry, Fourier transform infrared and mass spectrometry studies.

Nonlinear Modeling of Forced Magnetic Reconnection with Transient Perturbations

NASA Astrophysics Data System (ADS)

Beidler, Matthew T.; Callen, James D.; Hegna, Chris C.; Sovinec, Carl R.

2017-10-01

Externally applied 3D magnetic fields in tokamaks can penetrate into the plasma and lead to forced magnetic reconnection, and hence magnetic islands, on resonant surfaces. Analytic theory has been reasonably successful in describing many aspects of this paradigm with regard to describing the time asymptotic-steady state. However, understanding the nonlinear evolution into a low-slip, field-penetrated state, especially how MHD events such as sawteeth and ELMs precipitate this transition, is in its early development. We present nonlinear computations employing the extended-MHD code NIMROD, building on previous work by incorporating a temporally varying external perturbation as a simple model for an MHD event that produces resonant magnetic signals. A parametric series of proof-of-principle computations and accompanying analytical theory characterize the transition into a mode-locked state with an emphasis on detailing the temporal evolution properties. Supported by DOE OFES Grants DE-FG02-92ER54139, DE-FG02-86ER53218, and the U.S. DOE FES Postdoctoral Research program administered by ORISE and managed by ORAU under DOE contract DE-SC0014664.

A Car Transportation System in Cooperation by Multiple Mobile Robots for Each Wheel: iCART II

NASA Astrophysics Data System (ADS)

Kashiwazaki, Koshi; Yonezawa, Naoaki; Kosuge, Kazuhiro; Sugahara, Yusuke; Hirata, Yasuhisa; Endo, Mitsuru; Kanbayashi, Takashi; Shinozuka, Hiroyuki; Suzuki, Koki; Ono, Yuki

The authors proposed a car transportation system, iCART (intelligent Cooperative Autonomous Robot Transporters), for automation of mechanical parking systems by two mobile robots. However, it was difficult to downsize the mobile robot because the length of it requires at least the wheelbase of a car. This paper proposes a new car transportation system, iCART II (iCART - type II), based on “a-robot-for-a-wheel” concept. A prototype system, MRWheel (a Mobile Robot for a Wheel), is designed and downsized less than half the conventional robot. First, a method for lifting up a wheel by MRWheel is described. In general, it is very difficult for mobile robots such as MRWheel to move to desired positions without motion errors caused by slipping, etc. Therefore, we propose a follower's motion error estimation algorithm based on the internal force applied to each follower by extending a conventional leader-follower type decentralized control algorithm for cooperative object transportation. The proposed algorithm enables followers to estimate their motion errors and enables the robots to transport a car to a desired position. In addition, we analyze and prove the stability and convergence of the resultant system with the proposed algorithm. In order to extract only the internal force from the force applied to each robot, we also propose a model-based external force compensation method. Finally, proposed methods are applied to the car transportation system, the experimental results confirm their validity.

Coercion in psychiatry: the importance of extramural factors.

PubMed

Andersen, Kjeld; Nielsen, Bent

2016-11-01

Mechanical restraints and forced procedures in psychiatric wards are of major concern in Denmark and there is a desire to reduce these procedures to a minimum. So far, focus has primarily been on identifying and changing internal (intramural) factors when seeking to reduce coercion. To identify possible external (extramural) factors that may increase the risk of coercion during admission to a closed psychiatric ward. Using a retrospective case-controlled design, 235 patients admitted to a closed ward during 2011-2013 were randomly selected. Coercion comprised belt restraint, physical restraint, and forced medication. The data source was the electronic patient records, which include statutory information on all forced measures. Multiple logistic regression analyses were applied to calculate the risk (odds ratio, OR (95% confidence interval)) of forced measures being used. Out of the 235 patients, 66 (28%) were subject to coercion. The time of forced procedures was predominately during the first hours after admission. The risk of forced measures being applied was significantly higher if patients were involuntarily admitted (OR = 6.4 (3.4-11.9)), or were acutely intoxicated by substances at the time of admission (OR = 3.7 (1.7-8.2)). Extramural factors should be included when mental health authorities plan efforts to reduce coercion during admission to psychiatric wards. A reduced threshold for admission and improved integrated effort between mental health services and treatment for substance abuse could improve the course of disease for this group of patients and reduce the need for involuntary admissions and subsequently coercion.

Smart vortex generator transformed by change in ambient temperature and aerodynamic force

NASA Astrophysics Data System (ADS)

Ikeda, Tadashige; Masuda, Shinya; Ueda, Tetsuhiko

2007-04-01

A Smart Vortex Generator (SVG) concept has been proposed, where the SVG is autonomously transformed between an upright vortex-generating position in take-off and landing and a flat drag-reducing position in a cruise. This SVG is made of a Shape Memory Alloy (SMA), which is in the austenite phase and memorizes the upright position at high temperatures of the take-off and landing. At low temperatures during ascent the SVG is transformed into a martensite phase, and it lies flat against a base structure due to external or/and internal forces. In this paper, we examine whether the SVG can be transformed into the drag-reducing position by an aerodynamic force. To this end, numerical simulations are carried out with a simple line element model. The aerodynamic force applied on the SVG is calculated by a commercial CFD program. Result reveals that this SVG can be transformed from the upright vortex-generating position into the drag-reducing position by just an airplane climbing, and vice versa, if the SMA applied to the SVG has the two-way shape memory effect. If the SMA has the one-way shape memory effect, it is necessary to reduce the stiffness of the SVG or/and use a counter spring.

Foraging at the Edge of Chaos: Internal Clock versus External Forcing

NASA Astrophysics Data System (ADS)

Nicolis, S. C.; Fernández, J.; Pérez-Penichet, C.; Noda, C.; Tejera, F.; Ramos, O.; Sumpter, D. J. T.; Altshuler, E.

2013-06-01

Activity rhythms in animal groups arise both from external changes in the environment, as well as from internal group dynamics. These cycles are reminiscent of physical and chemical systems with quasiperiodic and even chaotic behavior resulting from “autocatalytic” mechanisms. We use nonlinear differential equations to model how the coupling between the self-excitatory interactions of individuals and external forcing can produce four different types of activity rhythms: quasiperiodic, chaotic, phase locked, and displaying over or under shooting. At the transition between quasiperiodic and chaotic regimes, activity cycles are asymmetrical, with rapid activity increases and slower decreases and a phase shift between external forcing and activity. We find similar activity patterns in ant colonies in response to varying temperature during the day. Thus foraging ants operate in a region of quasiperiodicity close to a cascade of transitions leading to chaos. The model suggests that a wide range of temporal structures and irregularities seen in the activity of animal and human groups might be accounted for by the coupling between collectively generated internal clocks and external forcings.

Solar and atmospheric forcing on mountain lakes.

PubMed

Luoto, Tomi P; Nevalainen, Liisa

2016-10-01

We investigated the influence of long-term external forcing on aquatic communities in Alpine lakes. Fossil microcrustacean (Cladocera) and macrobenthos (Chironomidae) community variability in four Austrian high-altitude lakes, determined as ultra-sensitive to climate change, were compared against records of air temperature, North Atlantic Oscillation (NAO) and solar forcing over the past ~400years. Summer temperature variability affected both aquatic invertebrate groups in all study sites. The influence of NAO and solar forcing on aquatic invertebrates was also significant in the lakes except in the less transparent lake known to have remained uniformly cold during the past centuries due to summertime snowmelt input. The results suggest that external forcing plays an important role in these pristine ecosystems through their impacts on limnology of the lakes. Not only does the air temperature variability influence the communities but also larger-scale external factors related to atmospheric circulation patterns and solar activity cause long-term changes in high-altitude aquatic ecosystems, through their connections to hydroclimatic conditions and light environment. These findings are important in the assessment of climate change impacts on aquatic ecosystems and in greater understanding of the consequences of external forcing on lake ontogeny. Copyright © 2016 Elsevier B.V. All rights reserved.

Dynamic force signal processing system of a robot manipulator

NASA Technical Reports Server (NTRS)

Uchiyama, M.; Kitagaki, K.; Hakomori, K.

1987-01-01

If dynamic noises such as those caused by the inertia forces of the hand can be eliminated from the signal of the force sensor installed on the wrist of the robot manipulator and if the necessary information of the external force can be detected with high sensitivity and high accuracy, a fine force feedback control for robots used in high speed and various fields will be possible. As the dynamic force sensing system, an external force estimate method with the extended Kalman filter is suggested and simulations and tests for a one axis force were performed. Later a dynamic signal processing system of six axes was composed and tested. The results are presented.

Thermal Noise Reduction of Mechanical Oscillators by Actively Controlled External Dissipative Forces

NASA Technical Reports Server (NTRS)

Liang, Shoudan; Medich, David; Czajkowsky, Daniel M.; Sheng, Sitong; Yuan, Jian-Yang; Shao, Zhifeng

1999-01-01

We show that the thermal fluctuations of very soft mechanical oscillators, such as the cantilever in an atomic force microscope (AFM), can be reduced without changing the stiffness of the spring or having to lower the environment temperature. We derive a theoretical relationship between the thermal fluctuations of an oscillator and an actively external-dissipative force. This relationship is verified by experiments with an AFM cantilever where the external active force is coupled through a magnetic field. With simple instrumentation, we have reduced the thermal noise amplitude of the cantilever by a factor of 3.4, achieving an apparent temperature of 25 K with the environment at 295K. This active noise reduction approach can significantly improve the accuracy of static position or static force measurements in a number of practical applications.

The lift force on a drop in unbounded plane Poiseuille flow

NASA Technical Reports Server (NTRS)

Wohl, P. R.

1976-01-01

The lift force on a deformable liquid sphere moving in steady, plane Poiseuille-Stokes flow and subjected to an external body force is calculated. The results are obtained by seeking a solution to Stokes' equations for the motion of the liquids inside and outside the slightly perturbed sphere surface, as expansions valid for small values of the ratio of the Weber number to the Reynolds number. When the ratio of the drop and external fluid viscosities is small, the lift exerted on a neutrally buoyant drop is found to be approximately one-tenth of the magnitude of the force reported by Wohl and Rubinow acting on the same drop in unbounded Poiseuille flow in a tube. The resultant trajectory of the drop is calculated and displayed as a function of the external body force.

Reversible Quantum Brownian Heat Engines for Electrons

NASA Astrophysics Data System (ADS)

Humphrey, T. E.; Newbury, R.; Taylor, R. P.; Linke, H.

2002-08-01

Brownian heat engines use local temperature gradients in asymmetric potentials to move particles against an external force. The energy efficiency of such machines is generally limited by irreversible heat flow carried by particles that make contact with different heat baths. Here we show that, by using a suitably chosen energy filter, electrons can be transferred reversibly between reservoirs that have different temperatures and electrochemical potentials. We apply this result to propose heat engines based on mesoscopic semiconductor ratchets, which can quasistatically operate arbitrarily close to Carnot efficiency.

Reversible quantum heat engines for electrons

NASA Astrophysics Data System (ADS)

Linke, Heiner; Humphrey, Tammy E.; Newbury, Richard; Taylor, Richard P.

2002-03-01

Brownian heat engines use local temperature gradients in asymmetric potentials to move particles against an external force. The energy efficiency of such machines is generally limited by irreversible heat flow carried by particles that make contact with different heat baths. Here we show that, by using a suitably chosen energy filter, electrons can be transferred reversibly between reservoirs that have different temperatures and electrochemical potentials. We apply this result to propose heat engines based on quantum ratchets, which can quasistatically operate at Carnot efficiency.

Strange nonchaotic self-oscillator

NASA Astrophysics Data System (ADS)

Jalnine, Alexey Yu.; Kuznetsov, Sergey P.

2016-08-01

An example of strange nonchaotic attractor (SNA) is discussed in a dissipative system of mechanical nature driven by a constant torque applied to one of the elements of the construction. So the external force is not oscillatory, and the system is autonomous. Components of the motion with incommensurable frequencies emerge due to the irrational ratio of the sizes of the involved rotating elements. We regard the phenomenon as strange nonchaotic self-oscillations, and its existence sheds new light on the question of feasibility of SNA in autonomous systems.

The neuromotor effects of transverse friction massage.

PubMed

Begovic, Haris; Zhou, Guang-Quan; Schuster, Snježana; Zheng, Yong-Ping

2016-12-01

Transverse friction massage (TFM), as an often used technique by therapists, is known for its effect in reducing the pain and loosing the scar tissues. Nevertheless, its effects on neuromotor driving mechanism including the electromechanical delay (EMD), force transmission and excitation-contraction (EC) coupling which could be used as markers of stiffness changes, has not been computed using ultrafast ultrasound (US) when combined with external sensors. Hence, the aim of this study was to find out produced neuromotor changes associated to stiffness when TFM was applied over Quadriceps femoris (QF) tendon in healthy subjcets. Fourteen healthy males and fifteen age-gender matched controls were recruited. Surface EMG (sEMG), ultrafast US and Force sensors were synchronized and signals were analyzed to depict the time delays corresponding to EC coupling, force transmission, EMD, torque and rate of force development (RFD). TFM has been found to increase the time corresponding to EC coupling and EMD, whilst, reducing the time belonging to force transmission during the voluntary muscle contractions. A detection of the increased time of EC coupling from muscle itself would suggest that TFM applied over the tendon shows an influence on changing the neuro-motor driving mechanism possibly via afferent pathways and therefore decreasing the active muscle stiffness. On the other hand, detection of decreased time belonging to force transmission during voluntary contraction would suggest that TFM increases the stiffness of tendon, caused by faster force transmission along non-contractile elements. Torque and RFD have not been influenced by TFM. Copyright © 2016 Elsevier Ltd. All rights reserved.

Infinity and Newton's Three Laws of Motion

NASA Astrophysics Data System (ADS)

Lee, Chunghyoung

2011-12-01

It is shown that the following three common understandings of Newton's laws of motion do not hold for systems of infinitely many components. First, Newton's third law, or the law of action and reaction, is universally believed to imply that the total sum of internal forces in a system is always zero. Several examples are presented to show that this belief fails to hold for infinite systems. Second, two of these examples are of an infinitely divisible continuous body with finite mass and volume such that the sum of all the internal forces in the body is not zero and the body accelerates due to this non-null net internal force. So the two examples also demonstrate the breakdown of the common understanding that according to Newton's laws a body under no external force does not accelerate. Finally, these examples also make it clear that the expression `impressed force' in Newton's formulations of his first and second laws should be understood not as `external force' but as `exerted force' which is the sum of all the internal and external forces acting on a given body, if the body is infinitely divisible.

Detecting changes in forced climate attractors with Wasserstein distance

NASA Astrophysics Data System (ADS)

Robin, Yoann; Yiou, Pascal; Naveau, Philippe

2017-07-01

The climate system can been described by a dynamical system and its associated attractor. The dynamics of this attractor depends on the external forcings that influence the climate. Such forcings can affect the mean values or variances, but regions of the attractor that are seldom visited can also be affected. It is an important challenge to measure how the climate attractor responds to different forcings. Currently, the Euclidean distance or similar measures like the Mahalanobis distance have been favored to measure discrepancies between two climatic situations. Those distances do not have a natural building mechanism to take into account the attractor dynamics. In this paper, we argue that a Wasserstein distance, stemming from optimal transport theory, offers an efficient and practical way to discriminate between dynamical systems. After treating a toy example, we explore how the Wasserstein distance can be applied and interpreted to detect non-autonomous dynamics from a Lorenz system driven by seasonal cycles and a warming trend.

Thermally and electrically controllable multiple high harmonics generation by harmonically driven quasi-two-dimensional electron gas

NASA Astrophysics Data System (ADS)

Maglevanny, I. I.; Smolar, V. A.; Karyakina, T. I.

2018-06-01

In this paper, we consider the activation processes in nonlinear meta-stable system based on a lateral (quasi-two-dimensional) superlattice and study the dynamics of such a system externally driven by a harmonic force. The internal control parameters are the longitudinal applied electric field and the sample temperature. The spontaneous transverse electric field is considered as an order parameter. The forced violations of order parameter are considered as a response of a system to periodic driving. We investigate the cooperative effects of self-organization and high harmonic forcing from the viewpoint of catastrophe theory and show the possibility of generation of third and higher odd harmonics in output signal that lead to distortion of its wave front. A higher harmonics detection strategy is further proposed and explained in detail by exploring the influences of system parameters on the response output of the system that are discussed through numerical simulations.

A solution to the problem of elastic half-plane with a cohesive edge crack

NASA Astrophysics Data System (ADS)

Thanh, Le Thi; Belaya, L. A.; Lavit, I. M.

2018-03-01

This paper considers the problem of extension of an elastic half-plane slackened by a rectilinear edge crack. The opposite edges of the crack are attracted to each other. The intensity of attracting forces – the forces of cohesion – depends on displacements of the edges; this dependence is nonlinear in the general case. External load and cohesive forces are related to each other by the condition of finite stresses at the crack tip. The authors apply Picard’s method of successive approximation. In each iteration, Irwin’s method is used to solve the problem of a half-plane with a crack, the edges of which are subjected to irregularly distributed load. The solution of the resulting integral equation is found by Galerkin’s method. The paper includes examples of calculations and their results. Some of them are compared with the data of previous studies.

Review: magnetically assisted resistance spot welding

DOE Office of Scientific and Technical Information (OSTI.GOV)

Li, Y. B.; Li, D. L.; Lin, Z. Q.

2016-02-25

Currently, the use of advanced high strength steels (AHSSs) is the most cost effective means of reducing vehicle body weight and maintaining structural integrity at the same time. However, AHSSs present a big challenge to the traditional resistance spot welding (RSW) widely applied in automotive industries because the rapid heating and cooling procedures during RSW produce hardened weld microstructures, which lower the ductility and fatigue properties of welded joints and raise the probability of interfacial failure under external loads. Changing process parameters or post-weld heat treatment may reduce the weld brittleness, but those traditional quality control methods also increase energymore » consumption and prolong cycle time. In recent years, a magnetically assisted RSW (MA-RSW) method was proposed, in which an externally applied magnetic field would interact with the conduction current to produce a Lorentz force that would affect weld nugget formation. This paper is a review of an experimental MA-RSW platform, the mode of the external magnetic field and the mechanism that controls nugget shape, weld microstructures and joint performance. In conclusion, the advantages of the MA-RSW method in improving the weldability of AHSSs are given, a recent application of the MA-RSW process to light metals is described and the outlook for the MA-RSW process is presented.« less

Designing the Army’s Future Active Duty Weapons of Mass Destruction Response: Is the Defense Chemical, Biological, Radiological, Nuclear and High-Yield Explosives Response Force (DCRF) the Right Force at the Right Time?

DTIC Science & Technology

2013-06-14

ever-evolving contemporary nature of external and internal threats to the safety and security of the American homeland, it becomes increasingly...Major Justin P. Hurt, 146 pages. With the ever-evolving contemporary nature of external and internal threats to the safety and security of the American...HAZMAT Hazardous Materials HRF Homeland Response Force HSPD Homeland Security Presidential Directive JFHQ Joint Force

Method and apparatus for simulating gravitational forces on a living organism

NASA Technical Reports Server (NTRS)

Thornton, W. E. (Inventor)

1983-01-01

A method and apparatus for simulating gravitational forces on a living organism wherein a series of negative pressures are externally applied to successive length-wise sections of a lower limb of the organism. The pressures decreasing progressively with distance of said limb sections from the heart of the organism. A casing defines a chamber adapted to contain the limb of the organism and is rigidified to resist collapse upon the application of negative pressures to the interior of the chamber. Seals extend inwardly from the casing for effective engagement with the limb of the organism and, in cooperation with the limb, subdivide the chamber into a plurality of compartments each in negative pressure communicating relation with the limb.

Triggering vacuum capillaries for pneumatic pumping and metering liquids in point-of-care immunoassays.

PubMed

Weng, Kuo-Yao; Chou, Nien-Jen; Cheng, Jya-Wei

2008-07-01

An innovative vacuum capillary pneumatic actuation concept that can be used for point-of-care testing has been investigated. The vacuum glass capillaries are encapsulated within a laminated pouch and incorporated into the fluidic card. Vacuum glass capillaries broken by external force such as finger pressure, generate the pneumatic forces to induce liquid flow in the fluidic system. The sizes of vacuum capillary play a vital role in the pumping and metering functions of the system. The luteinizing hormone (LH) chromatographic immunoassay performances in the fluidic cards show consistency comparable to that obtained by manual micropipetting. The vacuum capillary pneumatic actuation will be applied in other complex handling step bioassays and lab-on-a-chip devices.

Applications of Modern Hydrodynamics to Aeronautics. Part 1: Fundamental Concepts and the Most Important Theorems. Part 2: Applications

NASA Technical Reports Server (NTRS)

Prandtl, L.

1979-01-01

A discussion of the principles of hydrodynamics of nonviscous fluids in the case of motion of solid bodies in a fluid is presented. Formulae are derived to demonstrate the transition from the fluid surface to a corresponding 'control surface'. The external forces are compounded of the fluid pressures on the control surface and the forces which are exercised on the fluid by any solid bodies which may be inside of the control surfaces. Illustrations of these formulae as applied to the acquisition of transformations from a known simple flow to new types of flow for other boundaries are given. Theoretical and experimental investigations of models of airship bodies are presented.

Ultrasensitive Inertial and Force Sensors with Diamagnetically Levitated Magnets

NASA Astrophysics Data System (ADS)

Prat-Camps, J.; Teo, C.; Rusconi, C. C.; Wieczorek, W.; Romero-Isart, O.

2017-09-01

We theoretically show that a magnet can be stably levitated on top of a punctured superconductor sheet in the Meissner state without applying any external field. The trapping potential created by such induced-only superconducting currents is characterized for magnetic spheres ranging from tens of nanometers to tens of millimeters. Such a diamagnetically levitated magnet is predicted to be extremely well isolated from the environment. We propose to use it as an ultrasensitive force and inertial sensor. A magnetomechanical readout of its displacement can be performed by using superconducting quantum interference devices. An analysis using current technology shows that force and acceleration sensitivities on the order of 10-23 N /√{Hz } (for a 100-nm magnet) and 10-14 g /√{Hz } (for a 10-mm magnet) might be within reach in a cryogenic environment. Such remarkable sensitivities, both in force and acceleration, can be used for a variety of purposes, from designing ultrasensitive inertial sensors for technological applications (e.g., gravimetry, avionics, and space industry), to scientific investigations on measuring Casimir forces of magnetic origin and gravitational physics.

Role of phase synchronisation in turbulence

NASA Astrophysics Data System (ADS)

Moradi, Sara; Teaca, Bogdan; Anderson, Johan

2017-11-01

The role of the phase dynamics in turbulence is investigated. As a demonstration of the importance of the phase dynamics, a simplified system is used, namely the one-dimensional Burgers equation, which is evolved numerically. The system is forced via a known external force, with two components that are added into the evolution equations of the amplitudes and the phase of the Fourier modes, separately. In this way, we are able to control the impact of the force on the dynamics of the phases. In the absence of the direct forcing in the phase equation, it is observed that the phases are not stochastic as assumed in the Random Phase Approximation (RPA) models, and in contrast, the non-linear couplings result in intermittent locking of the phases to ± π/2. The impact of the force, applied purely on the phases, is to increase the occurrence of the phase locking events in which the phases of the modes in a wide k range are now locked to ± π/2, leading to a change in the dynamics of both phases and amplitudes, with a significant localization of the real space flow structures.

Operator evolution for ab initio electric dipole transitions of 4He

DOE PAGES

Schuster, Micah D.; Quaglioni, Sofia; Johnson, Calvin W.; ...

2015-07-24

A goal of nuclear theory is to make quantitative predictions of low-energy nuclear observables starting from accurate microscopic internucleon forces. A major element of such an effort is applying unitary transformations to soften the nuclear Hamiltonian and hence accelerate the convergence of ab initio calculations as a function of the model space size. The consistent simultaneous transformation of external operators, however, has been overlooked in applications of the theory, particularly for nonscalar transitions. We study the evolution of the electric dipole operator in the framework of the similarity renormalization group method and apply the renormalized matrix elements to the calculationmore » of the 4He total photoabsorption cross section and electric dipole polarizability. All observables are calculated within the ab initio no-core shell model. Furthermore, we find that, although seemingly small, the effects of evolved operators on the photoabsorption cross section are comparable in magnitude to the correction produced by including the chiral three-nucleon force and cannot be neglected.« less

Skin surface and sub-surface strain and deformation imaging using optical coherence tomography and digital image correlation

NASA Astrophysics Data System (ADS)

Hu, X.; Maiti, R.; Liu, X.; Gerhardt, L. C.; Lee, Z. S.; Byers, R.; Franklin, S. E.; Lewis, R.; Matcher, S. J.; Carré, M. J.

2016-03-01

Bio-mechanical properties of the human skin deformed by external forces at difference skin/material interfaces attract much attention in medical research. For instance, such properties are important design factors when one designs a healthcare device, i.e., the device might be applied directly at skin/device interfaces. In this paper, we investigated the bio-mechanical properties, i.e., surface strain, morphological changes of the skin layers, etc., of the human finger-pad and forearm skin as a function of applied pressure by utilizing two non-invasive techniques, i.e., optical coherence tomography (OCT) and digital image correlation (DIC). Skin deformation results of the human finger-pad and forearm skin were obtained while pressed against a transparent optical glass plate under the action of 0.5-24 N force and stretching naturally from 90° flexion to 180° full extension respectively. The obtained OCT images showed the deformation results beneath the skin surface, however, DIC images gave overall information of strain at the surface.

Demonstration of asymmetric electron conduction in pseudosymmetrical photosynthetic reaction centre proteins in an electrical circuit

PubMed Central

Kamran, Muhammad; Friebe, Vincent M.; Delgado, Juan D.; Aartsma, Thijs J.; Frese, Raoul N.; Jones, Michael R.

2015-01-01

Photosynthetic reaction centres show promise for biomolecular electronics as nanoscale solar-powered batteries and molecular diodes that are amenable to atomic-level re-engineering. In this work the mechanism of electron conduction across the highly tractable Rhodobacter sphaeroides reaction centre is characterized by conductive atomic force microscopy. We find, using engineered proteins of known structure, that only one of the two cofactor wires connecting the positive and negative termini of this reaction centre is capable of conducting unidirectional current under a suitably oriented bias, irrespective of the magnitude of the bias or the applied force at the tunnelling junction. This behaviour, strong functional asymmetry in a largely symmetrical protein–cofactor matrix, recapitulates the strong functional asymmetry characteristic of natural photochemical charge separation, but it is surprising given that the stimulus for electron flow is simply an externally applied bias. Reasons for the electrical resistance displayed by the so-called B-wire of cofactors are explored. PMID:25751412

Demonstration of asymmetric electron conduction in pseudosymmetrical photosynthetic reaction centre proteins in an electrical circuit.

PubMed

Kamran, Muhammad; Friebe, Vincent M; Delgado, Juan D; Aartsma, Thijs J; Frese, Raoul N; Jones, Michael R

2015-03-09

Photosynthetic reaction centres show promise for biomolecular electronics as nanoscale solar-powered batteries and molecular diodes that are amenable to atomic-level re-engineering. In this work the mechanism of electron conduction across the highly tractable Rhodobacter sphaeroides reaction centre is characterized by conductive atomic force microscopy. We find, using engineered proteins of known structure, that only one of the two cofactor wires connecting the positive and negative termini of this reaction centre is capable of conducting unidirectional current under a suitably oriented bias, irrespective of the magnitude of the bias or the applied force at the tunnelling junction. This behaviour, strong functional asymmetry in a largely symmetrical protein-cofactor matrix, recapitulates the strong functional asymmetry characteristic of natural photochemical charge separation, but it is surprising given that the stimulus for electron flow is simply an externally applied bias. Reasons for the electrical resistance displayed by the so-called B-wire of cofactors are explored.

Erasure of memory in paste by irradiation of ultrasonic waves

NASA Astrophysics Data System (ADS)

Nakahara, Akio; Yoneyama, Ryota; Ito, Maruto; Matsuo, Yousuke; Kitsunezaki, So

2017-06-01

Densely packed colloidal suspension, called paste, remembers the direction of applied forces, such as vibration and flow, and these memories kept in paste can be visualized as morphology of desiccation crack patterns. For example, when the paste remembers the direction of vibration, all primary cracks propagate in the direction perpendicular to the direction of initial vibration. On the other hand, when the paste remembers the direction of flow, all primary cracks propagate along the direction of initial flow. These results indicate that external forces imprint easy-breakable direction into paste as memories. Therefore, by controlling memories in paste, we can tune to produce various types of crack patterns, such as cellular, radial, lamellar, ring, spiral and lattice structures. Recently we have found that memories in paste can be erased by the irradiation of ultrasonic waves to paste as we obtain only isotropic and cellular crack patterns without any anisotropy related to memory effect. This method can be applied to increase the breaking strength of dried paste by homogenizing microstructure in paste.

Rigidity of a Vibrated Amorphous Bi-Dimensional Packing of Grains

NASA Astrophysics Data System (ADS)

Coulais, C.; Dauchot, O.

The Jamming transition can be seen as a general phenomenon occurring whenever a dense assembly of ``things'' gets stuck and resists to an externally applied shear stress. The mechanical response of a vibrated amorphous bi-dimensional packing of grains close to the Jamming transition is investigated. Stress is applied to the media through a constant torque rheometer while surface fraction is tuned around the jamming transition. The rheometer turns, no matter how low is the applied torque. However, its motion is strongly intermittent and displays scale invariance, the fluctuations being maximal at the Jamming transition, where dynamical correlation length had been found to be divergent. We compare our results to previous ones obtained while dragging an intruder at constant force in the same experimental set-up.

MEMS earthworm: a thermally actuated peristaltic linear micromotor

NASA Astrophysics Data System (ADS)

Arthur, Craig; Ellerington, Neil; Hubbard, Ted; Kujath, Marek

2011-03-01

This paper examines the design, fabrication and testing of a bio-mimetic MEMS (micro-electro mechanical systems) earthworm motor with external actuators. The motor consists of a passive mobile shuttle with two flexible diamond-shaped segments; each segment is independently squeezed by a pair of stationary chevron-shaped thermal actuators. Applying a specific sequence of squeezes to the earthworm segments, the shuttle can be driven backward or forward. Unlike existing inchworm drives that use clamping and thrusting actuators, the earthworm actuators apply only clamping forces to the shuttle, and lateral thrust is produced by the shuttle's compliant geometry. The earthworm assembly is fabricated using the PolyMUMPs process with planar dimensions of 400 µm width by 800 µm length. The stationary actuators operate within the range of 4-9 V and provide a maximum shuttle range of motion of 350 µm (approximately half its size), a maximum shuttle speed of 17 mm s-1 at 10 kHz, and a maximum dc shuttle force of 80 µN. The shuttle speed was found to vary linearly with both input voltage and input frequency. The shuttle force was found to vary linearly with the actuator voltage.

Ratchet Effects in Active Matter Systems

NASA Astrophysics Data System (ADS)

Reichhardt, C. J. Olson; Reichhardt, C.

2017-03-01

Ratchet effects can arise for single or collectively interacting Brownian particles on an asymmetric substrate when a net dc transport is produced by an externally applied ac driving force or by periodically flashing the substrate. Recently, a new class of active ratchet systems that do not require the application of external driving has been realized through the use of active matter; they are self-propelled units that can be biological or nonbiological in nature. When active materials such as swimming bacteria interact with an asymmetric substrate, a net dc directed motion can arise even without external driving, opening a wealth of possibilities such as sorting, cargo transport, or micromachine construction. We review the current status of active matter ratchets for swimming bacteria, cells, active colloids, and swarming models, focusing on the role of particle-substrate interactions. We describe ratchet reversals produced by collective effects and the use of active ratchets to transport passive particles. We discuss future directions including deformable substrates or particles, the role of different swimming modes, varied particle-particle interactions, and nondissipative effects.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Reichhardt, Cynthia Jane; Reichhardt, Charles

Ratchet effects can arise for single or collectively interacting Brownian particles on an asymmetric substrate when a net dc transport is produced by an externally applied ac driving force or by periodically flashing the substrate. Recently, a new class of active ratchet systems that do not require the application of external driving has been realized through the use of active matter; they are self-propelled units that can be biological or nonbiological in nature. When active materials such as swimming bacteria interact with an asymmetric substrate, a net dc directed motion can arise even without external driving, opening a wealth ofmore » possibilities such as sorting, cargo transport, or micromachine construction. We review the current status of active matter ratchets for swimming bacteria, cells, active colloids, and swarming models, focusing on the role of particle-substrate interactions. Here, we describe ratchet reversals produced by collective effects and the use of active ratchets to transport passive particles. We discuss future directions including deformable substrates or particles, the role of different swimming modes, varied particle–particle interactions, and nondissipative effects.« less

Nonlinear microrheology of dense colloidal suspensions: A mode-coupling theory

NASA Astrophysics Data System (ADS)

Gazuz, I.; Fuchs, M.

2013-03-01

A mode-coupling theory for the motion of a strongly forced probe particle in a dense colloidal suspension is presented. Starting point is the Smoluchowski equation for N bath and a single probe particle. The probe performs Brownian motion under the influence of a strong constant and uniform external force Fex. It is immersed in a dense homogeneous bath of (different) particles also performing Brownian motion. Fluid and glass states are considered; solvent flow effects are neglected. Based on a formally exact generalized Green-Kubo relation, mode coupling approximations are performed and an integration through transients approach applied. A microscopic theory for the nonlinear velocity-force relations of the probe particle in a dense fluid and for the (de-) localized probe in a glass is obtained. It extends the mode coupling theory of the glass transition to strongly forced tracer motion and describes active microrheology experiments. A force threshold is identified which needs to be overcome to pull the probe particle free in a glass. For the model of hard sphere particles, the microscopic equations for the threshold force and the probability density of the localized probe are solved numerically. Neglecting the spatial structure of the theory, a schematic model is derived which contains two types of bifurcation, the glass transition and the force-induced delocalization, and which allows for analytical and numerical solutions. We discuss its phase diagram, forcing effects on the time-dependent correlation functions, and the friction increment. The model was successfully applied to simulations and experiments on colloidal hard sphere systems [Gazuz , Phys. Rev. Lett.PRLTAO0031-900710.1103/PhysRevLett.102.248302 102, 248302 (2009)], while we provide detailed information on its derivation and general properties.

Midsole material-related force control during heel-toe running.

PubMed

Kersting, Uwe G; Brüggemann, Gert-Peter

2006-01-01

The impact maximum and rearfoot eversion have been used as indicators of load on internal structures in running. The midsole hardness of a typical running shoe was varied systematically to determine the relationship between external ground reaction force (GRF), in-shoe force, and kinematic variables. Eight subjects were tested during overground running at 4 m/s. Rearfoot movement as well as in-shoe forces and external GRF varied nonsystematically with midsole hardness. Kinematic parameters such as knee flexion and foot velocity at touchdown (TD), also varied nonsystematically with altered midsole hardness. Results demonstrate that considerable variations of in-shoe loading occur that were not depicted by external GRF measurements alone. Individuals apparently use different strategies of mechanical and neuromuscular adaptation in response to footwear modifications. In conclusion, shoe design effects on impact forces or other factors relating to injuries depend on the individual and therefore cannot be generalized.

Self-similar solutions of stationary Navier-Stokes equations

NASA Astrophysics Data System (ADS)

Shi, Zuoshunhua

2018-02-01

In this paper, we mainly study the existence of self-similar solutions of stationary Navier-Stokes equations for dimension n = 3 , 4. For n = 3, if the external force is axisymmetric, scaling invariant, C 1 , α continuous away from the origin and small enough on the sphere S2, we shall prove that there exists a family of axisymmetric self-similar solutions which can be arbitrarily large in the class Cloc3 , α (R3 0). Moreover, for axisymmetric external forces without swirl, corresponding to this family, the momentum flux of the flow along the symmetry axis can take any real number. However, there are no regular (U ∈ Cloc3 , α (R3 0)) axisymmetric self-similar solutions provided that the external force is a large multiple of some scaling invariant axisymmetric F which cannot be driven by a potential. In the case of dimension 4, there always exists at least one self-similar solution to the stationary Navier-Stokes equations with any scaling invariant external force in L 4 / 3 , ∞ (R4).

Defects formation and wave emitting from defects in excitable media

NASA Astrophysics Data System (ADS)

Ma, Jun; Xu, Ying; Tang, Jun; Wang, Chunni

2016-05-01

Abnormal electrical activities in neuronal system could be associated with some neuronal diseases. Indeed, external forcing can cause breakdown even collapse in nervous system under appropriate condition. The excitable media sometimes could be described by neuronal network with different topologies. The collective behaviors of neurons can show complex spatiotemporal dynamical properties and spatial distribution for electrical activities due to self-organization even from the regulating from central nervous system. Defects in the nervous system can emit continuous waves or pulses, and pacemaker-like source is generated to perturb the normal signal propagation in nervous system. How these defects are developed? In this paper, a network of neurons is designed in two-dimensional square array with nearest-neighbor connection type; the formation mechanism of defects is investigated by detecting the wave propagation induced by external forcing. It is found that defects could be induced under external periodical forcing under the boundary, and then the wave emitted from the defects can keep balance with the waves excited from external forcing.

A better way of fitting clips? A comparative study with respect to physical workload.

PubMed

Gaudez, Clarisse; Wild, Pascal; Aublet-Cuvelier, Agnès

2015-11-01

The clip fitting task is a frequently encountered assembly operation in the car industry. It can cause upper limb pain. During task laboratory simulations, upper limb muscular activity and external force were compared for 4 clip fitting methods: with the bare hand, with an unpowered tool commonly used at a company and with unpowered and powered prototype tools. None of the 4 fitting methods studied induced a lower overall workload than the other three. Muscle activity was lower at the dominant limb when using the unpowered tools and at the non-dominant limb with the bare hand or with the powered tool. Fitting clips with the bare hand required a higher external force than fitting with the three tools. Evaluation of physical workload was different depending on whether external force or muscle activity results were considered. Measuring external force only, as recommended in several standards, is insufficient for evaluating physical workload. Copyright © 2015 Elsevier Ltd and The Ergonomics Society. All rights reserved.

Acoustic Interaction Forces and Torques Acting on Suspended Spheres in an Ideal Fluid.

PubMed

Lopes, J Henrique; Azarpeyvand, Mahdi; Silva, Glauber T

2016-01-01

In this paper, the acoustic interaction forces and torques exerted by an arbitrary time-harmonic wave on a set of N objects suspended in an inviscid fluid are theoretically analyzed. We utilize the partial-wave expansion method with translational addition theorem and re-expansion of multipole series to solve the related multiple scattering problem. We show that the acoustic interaction force and torque can be obtained using the farfield radiation force and torque formulas. To exemplify the method, we calculate the interaction forces exerted by an external traveling and standing plane wave on an arrangement of two and three olive-oil droplets in water. The droplets' radii are comparable to the wavelength (i.e., Mie scattering regime). The results show that the acoustic interaction forces present an oscillatory spatial distribution which follows the pattern formed by interference between the external and rescattered waves. In addition, acoustic interaction torques arise on the absorbing droplets whenever a nonsymmetric wavefront is formed by the external and rescattered waves' interference.

Nonlinear Elasticity

NASA Astrophysics Data System (ADS)

Fu, Y. B.; Ogden, R. W.

2001-05-01

This collection of papers by leading researchers in the field of finite, nonlinear elasticity concerns itself with the behavior of objects that deform when external forces or temperature gradients are applied. This process is extremely important in many industrial settings, such as aerospace and rubber industries. This book covers the various aspects of the subject comprehensively with careful explanations of the basic theories and individual chapters each covering a different research direction. The authors discuss the use of symbolic manipulation software as well as computer algorithm issues. The emphasis is placed firmly on covering modern, recent developments, rather than the very theoretical approach often found. The book will be an excellent reference for both beginners and specialists in engineering, applied mathematics and physics.

Alternative methods to model frictional contact surfaces using NASTRAN

NASA Technical Reports Server (NTRS)

Hoang, Joseph

1992-01-01

Elongated (slotted) holes have been used extensively for the integration of equipment into Spacelab racks. In the past, this type of interface has been modeled assuming that there is not slippage between contact surfaces, or that there is no load transfer in the direction of the slot. Since the contact surfaces are bolted together, the contact friction provides a load path determined by the normal applied force (bolt preload) and the coefficient of friction. Three alternate methods that utilize spring elements, externally applied couples, and stress dependent elements are examined to model the contacted surfaces. Results of these methods are compared with results obtained from methods that use GAP elements and rigid elements.

Hydrological fine-structure evolution as a proxy of water mass property changes in the Tyrrhenian Sea

NASA Astrophysics Data System (ADS)

Durante, Sara; Schroeder, Katrin; Sparnocchia, Stefania; Mazzei, Luca; Borghini, Mireno; Pierini, Stefano

2017-04-01

The variability of the Tyrrhenian basin water masses properties, as inferred by the evolution of the typical step-like profile of the water column, is analyzed from 2003 to 2016. The dataset contains hydrological time series obtained in two deep control stations at a depth of about 3500 m. The study follows the evolution of double diffusion processes (a coherent basin feature) that leads to well-defined and permanent staircases. In each profile, four main steps can be recognized between 400 m and 2500 m both in conservative temperature (CT) and absolute salinity (SA), the main one having a thickness of about 400 m. The Tyrrhenian Sea is a not particularly dynamic basin if compared with other areas of the Mediterranean Sea, yet the staircases show large hydrological and depth changes. In particular, an increase of CT and SA and an uplifting are observed in the second part of the time series. Such changes can be due to both internal and external forcing. To discern the nature of the forcing, a suitable method [1] has been applied to our case study. Changes in SA are found to be similar along both isobars and neutral surfaces, so they can be ascribed to an external forcing. On the other hand, the CT shows different trends along isobars and neutral surfaces: this suggests that internal forcing can play an important role. The new Western Mediterranean Deep Water formed in severe winters after 2004-2005 and later in the Gulf of Lion (during the so-called Western Mediterranean Transition [2]) is suggested to be an external forcing producing the observed variability. Oscillatory movements of the neutral surfaces can also be observed after 2010. Computation of heat and salt fluxes (both for the whole water column and for each single step) sheds light on the conservative character of hydrological parameters of the step-system. [1] Bindoff, N.L., McDougall, T.J., 1994. J. Phys. Oceanogr. 24, 1137-1152. [2] Schroeder, K., G. P.Gasparini, M. Tangherlini, and M. Astraldi, 2006. Geophys. Res. Lett., 33, L21607, doi:10.1029/2006GL027121.

Precession and atmospheric CO2 modulated variability of sea ice in the central Okhotsk Sea since 130,000 years ago

NASA Astrophysics Data System (ADS)

Lo, Li; Belt, Simon T.; Lattaud, Julie; Friedrich, Tobias; Zeeden, Christian; Schouten, Stefan; Smik, Lukas; Timmermann, Axel; Cabedo-Sanz, Patricia; Huang, Jyh-Jaan; Zhou, Liping; Ou, Tsong-Hua; Chang, Yuan-Pin; Wang, Liang-Chi; Chou, Yu-Min; Shen, Chuan-Chou; Chen, Min-Te; Wei, Kuo-Yen; Song, Sheng-Rong; Fang, Tien-Hsi; Gorbarenko, Sergey A.; Wang, Wei-Lung; Lee, Teh-Quei; Elderfield, Henry; Hodell, David A.

2018-04-01

Recent reduction in high-latitude sea ice extent demonstrates that sea ice is highly sensitive to external and internal radiative forcings. In order to better understand sea ice system responses to external orbital forcing and internal oscillations on orbital timescales, here we reconstruct changes in sea ice extent and summer sea surface temperature (SSST) over the past 130,000 yrs in the central Okhotsk Sea. We applied novel organic geochemical proxies of sea ice (IP25), SSST (TEX86L) and open water marine productivity (a tri-unsaturated highly branched isoprenoid and biogenic opal) to marine sediment core MD01-2414 (53°11.77‧N, 149°34.80‧E, water depth 1123 m). To complement the proxy data, we also carried out transient Earth system model simulations and sensitivity tests to identify contributions of different climatic forcing factors. Our results show that the central Okhotsk Sea was ice-free during Marine Isotope Stage (MIS) 5e and the early-mid Holocene, but experienced variable sea ice cover during MIS 2-4, consistent with intervals of relatively high and low SSST, respectively. Our data also show that the sea ice extent was governed by precession-dominated insolation changes during intervals of atmospheric CO2 concentrations ranging from 190 to 260 ppm. However, the proxy record and the model simulation data show that the central Okhotsk Sea was near ice-free regardless of insolation forcing throughout the penultimate interglacial, and during the Holocene, when atmospheric CO2 was above ∼260 ppm. Past sea ice conditions in the central Okhotsk Sea were therefore strongly modulated by both orbital-driven insolation and CO2-induced radiative forcing during the past glacial/interglacial cycle.

Force measurements by micromanipulation of a single actin filament by glass needles

NASA Astrophysics Data System (ADS)

Kishino, Akiyoshi; Yanagida, Toshio

1988-07-01

Single actin filaments (~7nm in diameter) labelled with fluorescent phalloidin can be clearly seen by video-fluorescence microscopy1. This technique has been used to observe motions of single filaments in solution and in several in vitro movement assays1-5. In a further development of the technique, we report here a method to catch and manipulate a single actin filament (F-actin) by glass microneedles under conditions in which external force on the filament can be applied and measured. Using this method, we directly measured the tensile strength of a filament (the force necessary to break the bond between two actin monomers) and the force required for a filament to be moved by myosin or its proteolytic fragment bound to a glass surface in the presence of ATP. The first result shows that the tensile strength of the F-actin-phalloidin complex is comparable with the average force exerted on a single thin filament in muscle fibres during isometric contraction. This force is increased only slightly by tropomyosin. The second measurement shows that the myosin head (subfragment-1) can produce the same ATP-dependent force as intact myosin. The magnitude of this force is comparable with that produced by each head of myosin in muscle during isometric contraction.

Effect of lateral offset center of rotation in reverse total shoulder arthroplasty: a biomechanical study.

PubMed

Henninger, Heath B; Barg, Alexej; Anderson, Andrew E; Bachus, Kent N; Burks, Robert T; Tashjian, Robert Z

2012-09-01

Lateral offset center of rotation (COR) reduces the incidence of scapular notching and potentially increases external rotation range of motion (ROM) after reverse total shoulder arthroplasty (rTSA). The purpose of this study was to determine the biomechanical effects of changing COR on abduction and external rotation ROM, deltoid abduction force, and joint stability. A biomechanical shoulder simulator tested cadaveric shoulders before and after rTSA. Spacers shifted the COR laterally from baseline rTSA by 5, 10, and 15 mm. Outcome measures of resting abduction and external rotation ROM, and abduction and dislocation (lateral and anterior) forces were recorded. Resting abduction increased 20° vs native shoulders and was unaffected by COR lateralization. External rotation decreased after rTSA and was unaffected by COR lateralization. The deltoid force required for abduction significantly decreased 25% from native to baseline rTSA. COR lateralization progressively eliminated this mechanical advantage. Lateral dislocation required significantly less force than anterior dislocation after rTSA, and both dislocation forces increased with lateralization of the COR. COR lateralization had no influence on ROM (adduction or external rotation) but significantly increased abduction and dislocation forces. This suggests the lower incidence of scapular notching may not be related to the amount of adduction deficit after lateral offset rTSA but may arise from limited impingement of the humeral component on the lateral scapula due to a change in joint geometry. Lateralization provides the benefit of increased joint stability, but at the cost of increasing deltoid abduction forces. Copyright © 2012 Journal of Shoulder and Elbow Surgery Board of Trustees. Published by Mosby, Inc. All rights reserved.

An analytical approach to the external force-free motion of pendulums on surfaces of constant curvature

NASA Astrophysics Data System (ADS)

Rubio, Rafael M.; Salamanca, Juan J.

2018-07-01

The dynamics of external force free motion of pendulums on surfaces of constant Gaussian curvature is addressed when the pivot moves along a geodesic obtaining the Lagrangian of the system. As an application it is possible the study of elastic and quantum pendulums.

An active simulator for neonatal intubation: Design, development and assessment.

PubMed

Baldoli, Ilaria; Tognarelli, Selene; Vangi, Ferdinando; Panizza, Davide; Scaramuzzo, Rosa T; Cuttano, Armando; Laschi, Cecilia; Menciassi, Arianna

2017-01-01

This study describes the technical realization and the pre-clinical validation of a instrumented neonatal intubation skill trainer able to provide objective feedback for the improvement of clinical competences required for such a delicate procedure. The Laerdal ® Neonatal Intubation Trainer was modified by applying pressure sensors on areas that are mainly subject to stress and potential injuries. Punctual Force Sensing Resistors (FSRs) were characterized and fixed on the external side of the airway structure on the dental arches and epiglottis. A custom silicone tongue was designed and developed to integrate a matrix textile sensor for mapping the pressure applied on its whole surface. The assessment of the developed tool was performed by nine clinical experts who were asked to practice three intubation procedures apiece. Median and maximum forces, over threshold events (i.e. 2N for gingival arch sensors and 7N for epiglottis and tongue sensors respectively) and execution time were measured for each trainee. Data analysis from training sessions revealed that the epiglottis is the point mainly stressed during an intubation procedure (maximum value: 16.69N, median value: 3.11N), while the analysis carried out on the pressure distribution on the instrumented tongue provided information on both force values and distribution, according to clinicians' performance. The debriefing phase was used to enhance the clinicians' awareness of applied force and gestures performed, confirming that the present study is an adequate starting point for achieving and optimizing neonatal intubation skills for both residents and expert clinicians. Copyright © 2016 IPEM. Published by Elsevier Ltd. All rights reserved.

Bubble Dynamics, Two-Phase Flow, and Boiling Heat Transfer in Microgravity

NASA Technical Reports Server (NTRS)

Chung, Jacob N.

1996-01-01

The objective of the research is to study the feasibility of employing an external force to replace the buoyancy force in order to maintain nucleate boiling in microgravity. We have found that a bulk velocity field, an electric field and an acoustic field could each play the role of the gravity field in microgravity. Nucleate boiling could be maintained by any one of the three external force fields in space.

Elastic metamaterial beam with remotely tunable stiffness

NASA Astrophysics Data System (ADS)

Qian, Wei; Yu, Zhengyue; Wang, Xiaole; Lai, Yun; Yellen, Benjamin B.

2016-02-01

We demonstrate a dynamically tunable elastic metamaterial, which employs remote magnetic force to adjust its vibration absorption properties. The 1D metamaterial is constructed from a flat aluminum beam milled with a linear array of cylindrical holes. The beam is backed by a thin elastic membrane, on which thin disk-shaped permanent magnets are mounted. When excited by a shaker, the beam motion is tracked by a Laser Doppler Vibrometer, which conducts point by point scanning of the vibrating element. Elastic waves are unable to propagate through the beam when the driving frequency excites the first elastic bending mode in the unit cell. At these frequencies, the effective mass density of the unit cell becomes negative, which induces an exponentially decaying evanescent wave. Due to the non-linear elastic properties of the membrane, the effective stiffness of the unit cell can be tuned with an external magnetic force from nearby solenoids. Measurements of the linear and cubic static stiffness terms of the membrane are in excellent agreement with experimental measurements of the bandgap shift as a function of the applied force. In this implementation, bandgap shifts by as much as 40% can be achieved with ˜30 mN of applied magnetic force. This structure has potential for extension in 2D and 3D, providing a general approach for building dynamically tunable elastic metamaterials for applications in lensing and guiding elastic waves.

Determining residual reduction algorithm kinematic tracking weights for a sidestep cut via numerical optimization.

PubMed

Samaan, Michael A; Weinhandl, Joshua T; Bawab, Sebastian Y; Ringleb, Stacie I

2016-12-01

Musculoskeletal modeling allows for the determination of various parameters during dynamic maneuvers by using in vivo kinematic and ground reaction force (GRF) data as inputs. Differences between experimental and model marker data and inconsistencies in the GRFs applied to these musculoskeletal models may not produce accurate simulations. Therefore, residual forces and moments are applied to these models in order to reduce these differences. Numerical optimization techniques can be used to determine optimal tracking weights of each degree of freedom of a musculoskeletal model in order to reduce differences between the experimental and model marker data as well as residual forces and moments. In this study, the particle swarm optimization (PSO) and simplex simulated annealing (SIMPSA) algorithms were used to determine optimal tracking weights for the simulation of a sidestep cut. The PSO and SIMPSA algorithms were able to produce model kinematics that were within 1.4° of experimental kinematics with residual forces and moments of less than 10 N and 18 Nm, respectively. The PSO algorithm was able to replicate the experimental kinematic data more closely and produce more dynamically consistent kinematic data for a sidestep cut compared to the SIMPSA algorithm. Future studies should use external optimization routines to determine dynamically consistent kinematic data and report the differences between experimental and model data for these musculoskeletal simulations.

Modified atomic force microscope applied to the measurement of elastic modulus for a single peptide molecule

NASA Astrophysics Data System (ADS)

Ptak, Arkadiusz; Takeda, Seiji; Nakamura, Chikashi; Miyake, Jun; Kageshima, Masami; Jarvis, Suzanne P.; Tokumoto, Hiroshi

2001-09-01

A modified atomic force microscopy (AFM) system, based on a force modulation technique, has been used to find an approximate value for the elastic modulus of a single peptide molecule directly from a mechanical test. For this purpose a self-assembled monolayer built from two kinds of peptides, reactive (able to anchor to the AFM tip) and nonreactive, was synthesized. In a typical experiment a single C3K30C (C=cysteine, K=lysine) peptide molecule was stretched between a Au(111) substrate and the gold-coated tip of an AFM cantilever to which it was attached via gold-sulfur bonds. The amplitude of the cantilever oscillations, due to an external force applied via a magnetic particle to the cantilever, was recorded by a lock-in amplifier and recalculated into stiffness of the stretched molecule. A longitudinal Young's modulus for the α-helix of a single peptide molecule and for the elongated state of this molecule has been estimated. The obtained values; 1.2±0.3 and 50±15 GPa, for the peptide α-helix and elongated peptide backbone, respectively, seem to be reasonable comparing them to the Young's modulus of protein crystals and linear organic polymers. We believe this research opens up a means by which scientists can perform quantitative studies of the elastic properties of single molecule, especially of biologically important polymers like peptides or DNA.

Modelling and characteristic analysis of tri-axle trucks with hydraulically interconnected suspensions

NASA Astrophysics Data System (ADS)

Ding, Fei; Han, Xu; Luo, Zhen; Zhang, Nong

2012-12-01

In this paper, a new hydraulically interconnected suspension (HIS) system is proposed for the implementation of a resistance control for the pitch and bounce modes of tri-axle heavy trucks. A lumped-mass half-truck model is established using the free-body diagram method. The equations of motion of a mechanical and hydraulic coupled system are developed by incorporating the hydraulic strut forces into the mechanical subsystem as externally applied forces. The transfer matrix method (TMM) is used to evaluate the impedance matrix of the hydraulic subsystem consisting of models of fluid pipes, damper valves, accumulators, and three-way junctions. The TMM is further applied to find the quantitative relationships between the hydraulic strut forces and boundary flow of the mechanical-fluid interactive subsystem. The modal analysis method is employed to perform the vibration analysis between the trucks with the conventional suspension and the proposed HIS. Comparison analysis focuses on free vibration with identified eigenvalues and eigenvectors, isolation vibration capacity, and force vibration in terms of the power spectrum density responses. The obtained results show the effectiveness of the proposed HIS system in reducing the pitch motion of sprung mass and simultaneously maintaining the ride comfort. The pitch stiffness is increased while the bounce stiffness is slightly softened. The peak values of sprung mass and wheel hop motions are greatly reduced, and the vibration decay rate of sprung mass is also significantly increased.

Dielectrophoresis-magnetophoresis force driven magnetic nanoparticle movement in transformer oil based magnetic fluids.

PubMed

Lee, Jong-Chul; Lee, Sangyoup

2013-09-01

Magnetic fluid is a stable colloidal mixture contained magnetic nanoparticles coated with a surfactant. Recently, it was found that the fluid has properties to increase heat transfer and dielectric characteristics due to the added magnetic nanoparticles in transformer oils. The magnetic nanoparticles in the fluid experience an electrical force directed toward the place of maximum electric field strength when the electric field is applied. And when the external magnetic field is applied, the magnetic nanoparticles form long chains oriented along the direction of the field. The behaviors of magnetic nanoparticles in both the fields must play an important role in changing the heat transfer and dielectric characteristics of the fluids. In this study, we visualized the movement of magnetic nanoparticles influenced by both the fields applied in-situ. It was found that the magnetic nanoparticles travel in the region near the electrode by the electric field and form long chains along the field direction by the magnetic field. It can be inferred that the movement of magnetic nanoparticles appears by both the fields, and the breakdown voltage of transformer oil based magnetic fluids might be influenced according to the dispersion of magnetic nanoparticles.

A novel torsional exciter for modal vibration testing of large rotating machinery

NASA Astrophysics Data System (ADS)

Sihler, Christof

2006-10-01

A novel exciter for applying a dynamic torsional force to a rotating structure is presented in this paper. It has been developed at IPP in order to perform vibration tests with shaft assemblies of large flywheel generators (synchronous machines). The electromagnetic exciter (shaker) needs no fixture to the rotating shaft because the torque is applied by means of the stator winding of an electrical machine. Therefore, the exciter can most easily be applied in cases where a three-phase electrical machine (a motor or generator) is part of the shaft assembly. The oscillating power for the shaker is generated in a separate current-controlled DC circuit with an inductor acting as a buffer storage of magnetic energy. An AC component with adjustable frequency is superimposed on the inductor current in order to generate pulsating torques acting on the rotating shaft with the desired waveform and frequency. Since this torsional exciter does not require an external power source, can easily be installed (without contact to the rotating structure) and provides dynamic torsional forces which are sufficient for multi-megawatt applications, it is best suited for on-site tests of large rotating machinery.

A wearable pressure sensor based on ultra-violet/ozone microstructured carbon nanotube/polydimethylsiloxane arrays for electronic skins.

PubMed

Yu, Guohui; Hu, Jingdong; Tan, Jianping; Gao, Yang; Lu, Yongfeng; Xuan, Fuzhen

2018-03-16

Pressure sensors with high performance (e.g., a broad pressure sensing range, high sensitivities, rapid response/relaxation speeds, temperature-stable sensing), as well as a cost-effective and highly efficient fabrication method are highly desired for electronic skins. In this research, a high-performance pressure sensor based on microstructured carbon nanotube/polydimethylsiloxane arrays was fabricated using an ultra-violet/ozone (UV/O 3 ) microengineering technique. The UV/O 3 microengineering technique is controllable, cost-effective, and highly efficient since it is conducted at room temperature in an ambient environment. The pressure sensor offers a broad pressure sensing range (7 Pa-50 kPa), a sensitivity of ∼ -0.101 ± 0.005 kPa -1 (<1 kPa), a fast response/relaxation speed of ∼10 ms, a small dependence on temperature variation, and a good cycling stability (>5000 cycles), which is attributed to the UV/O 3 engineered microstructures that amplify and transfer external applied forces and rapidly store/release the energy during the PDMS deformation. The sensors developed show the capability to detect external forces and monitor human health conditions, promising for the potential applications in electronic skin.

A wearable pressure sensor based on ultra-violet/ozone microstructured carbon nanotube/polydimethylsiloxane arrays for electronic skins

NASA Astrophysics Data System (ADS)

Yu, Guohui; Hu, Jingdong; Tan, Jianping; Gao, Yang; Lu, Yongfeng; Xuan, Fuzhen

2018-03-01

Pressure sensors with high performance (e.g., a broad pressure sensing range, high sensitivities, rapid response/relaxation speeds, temperature-stable sensing), as well as a cost-effective and highly efficient fabrication method are highly desired for electronic skins. In this research, a high-performance pressure sensor based on microstructured carbon nanotube/polydimethylsiloxane arrays was fabricated using an ultra-violet/ozone (UV/O3) microengineering technique. The UV/O3 microengineering technique is controllable, cost-effective, and highly efficient since it is conducted at room temperature in an ambient environment. The pressure sensor offers a broad pressure sensing range (7 Pa-50 kPa), a sensitivity of ˜ -0.101 ± 0.005 kPa-1 (<1 kPa), a fast response/relaxation speed of ˜10 ms, a small dependence on temperature variation, and a good cycling stability (>5000 cycles), which is attributed to the UV/O3 engineered microstructures that amplify and transfer external applied forces and rapidly store/release the energy during the PDMS deformation. The sensors developed show the capability to detect external forces and monitor human health conditions, promising for the potential applications in electronic skin.

Influence of the Location of Attractive Polymer-Pore Interactions on Translocation Dynamics.

PubMed

Ghosh, Bappa; Chaudhury, Srabanti

2018-01-11

We probe the influence of polymer-pore interactions on the translocation dynamics using Langevin dynamics simulations. We investigate the effect of the strength and location of the polymer-pore interaction using nanopores that are partially charged either at the entry or the exit or on both sides of the pore. We study the change in the translocation time as a function of the strength of the polymer-pore interaction for a given chain length and under the effect of an externally applied field. Under a moderate driving force and a chain length longer than the length of the pore, the translocation time shows a nonmonotonic increase with an increase in the attractive interaction. Also, an interaction on the cis side of the pore can increase the translocation probability. In the presence of an external field and a strong attractive force, the translocation time for shorter chains is independent of the polymer-pore interaction at the entry side of the pore, whereas an interaction on the trans side dominates the translocation process. Our simulation results are rationalized by a qualitative analysis of the free energy landscape for polymer translocation.

Optical tweezers with 2.5 kHz bandwidth video detection for single-colloid electrophoresis

NASA Astrophysics Data System (ADS)

Otto, Oliver; Gutsche, Christof; Kremer, Friedrich; Keyser, Ulrich F.

2008-02-01

We developed an optical tweezers setup to study the electrophoretic motion of colloids in an external electric field. The setup is based on standard components for illumination and video detection. Our video based optical tracking of the colloid motion has a time resolution of 0.2ms, resulting in a bandwidth of 2.5kHz. This enables calibration of the optical tweezers by Brownian motion without applying a quadrant photodetector. We demonstrate that our system has a spatial resolution of 0.5nm and a force sensitivity of 20fN using a Fourier algorithm to detect periodic oscillations of the trapped colloid caused by an external ac field. The electrophoretic mobility and zeta potential of a single colloid can be extracted in aqueous solution avoiding screening effects common for usual bulk measurements.

Electrodeless RF Plasma Thruster Using m = 0 Coil

NASA Astrophysics Data System (ADS)

Nishimura, Shuichi; Arai, Daisuke; Kuwahara, Daisuke; Shinohara, Shunjiro

2016-10-01

In order to realize a deep space exploration in the future, we have been developing a next generation electrodeless electric propulsion system by electromagnetic acceleration of high-density helicon plasma. A new proposed method by m = 0 coil plasma acceleration (m is an azimuthal mode number) is based on the Lorentz force: a product of the induced azimuthal current by supplying an AC current to the m = 0 coil and the radial component of the externally applied magnetic field (divergent field configuration). Here, we have investigated the dependences of an ion velocity and an electron density on the external parameters, leading to optimized conditions, using the SHD device. By increasing AC current on the order of 100 A, we could see the increase of ion velocity and electron density by a factor of 2.5 and 3, respectively.

Malaria vaccine development and how external forces shape it: an overview.

PubMed

Lorenz, Veronique; Karanis, Gabriele; Karanis, Panagiotis

2014-06-30

The aim of this paper is to analyse the current status and scientific value of malaria vaccine approaches and to provide a realistic prognosis for future developments. We systematically review previous approaches to malaria vaccination, address how vaccine efforts have developed, how this issue may be fixed, and how external forces shape vaccine development. Our analysis provides significant information on the various aspects and on the external factors that shape malaria vaccine development and reveal the importance of vaccine development in our society.

Characterization of magnetic force microscopy probe tip remagnetization for measurements in external in-plane magnetic fields

DOE Office of Scientific and Technical Information (OSTI.GOV)

Weis, Tanja; Engel, Dieter; Ehresmann, Arno

2008-12-15

A quantitative analysis of magnetic force microscopy (MFM) images taken in external in-plane magnetic fields is difficult because of the influence of the magnetic field on the magnetization state of the magnetic probe tip. We prepared calibration samples by ion bombardment induced magnetic patterning with a topographically flat magnetic pattern magnetically stable in a certain external magnetic field range for a quantitative characterization of the MFM probe tip magnetization in point-dipole approximation.

Experimental Investigation of a Piezo-Optical Transducer for Highly Sensitive Strain Gauges

NASA Astrophysics Data System (ADS)

Paulish, A. G.; Zagubisalo, P. S.; Barakov, V. N.; Pavlov, M. A.

2018-03-01

The characteristics of a piezo-optical transducer of a new design with high strain sensitivity at compact size have been studied.The original form of the photoelastic element provides a considerable increase in the stress in its working area at a given external force, resulting in an increase in the sensitivity of the transducer. The main characteristics of the transducer were measured using a specially designed device. The strain at a given applied force was calculated using a developed mathematical model of the transducer. As a result, the sensitivity to the relative strain was Δ x/ x=3 · 10-10, the dynamic range was at least four orders of magnitude higher and the gauge factor three orders of magnitude higher than those of strain-resistive gauges.

The possibility of multi-layer nanofabrication via atomic force microscope-based pulse electrochemical nanopatterning

NASA Astrophysics Data System (ADS)

Kim, Uk Su; Morita, Noboru; Lee, Deug Woo; Jun, Martin; Park, Jeong Woo

2017-05-01

Pulse electrochemical nanopatterning, a non-contact scanning probe lithography process using ultrashort voltage pulses, is based primarily on an electrochemical machining process using localized electrochemical oxidation between a sharp tool tip and the sample surface. In this study, nanoscale oxide patterns were formed on silicon Si (100) wafer surfaces via electrochemical surface nanopatterning, by supplying external pulsed currents through non-contact atomic force microscopy. Nanoscale oxide width and height were controlled by modulating the applied pulse duration. Additionally, protruding nanoscale oxides were removed completely by simple chemical etching, showing a depressed pattern on the sample substrate surface. Nanoscale two-dimensional oxides, prepared by a localized electrochemical reaction, can be defined easily by controlling physical and electrical variables, before proceeding further to a layer-by-layer nanofabrication process.

Direct observation of λ-DNA molecule reversal movement within microfluidic channels under electric field with single molecule imaging technique

NASA Astrophysics Data System (ADS)

Fengyun, Yang; Kaige, Wang; Dan, Sun; Wei, Zhao; Hai-qing, Wang; Xin, He; Gui-ren, Wang; Jin-tao, Bai

2016-07-01

The electrodynamic characteristics of single DNA molecules moving within micro-/nano-fluidic channels are important in the design of biomedical chips and bimolecular sensors. In this study, the dynamic properties of λ-DNA molecules transferring along the microchannels driven by the external electrickinetic force were systemically investigated with the single molecule fluorescence imaging technique. The experimental results indicated that the velocity of DNA molecules was strictly dependent on the value of the applied electric field and the diameter of the channel. The larger the external electric field, the larger the velocity, and the more significant deformation of DNA molecules. More meaningfully, it was found that the moving directions of DNA molecules had two completely different directions: (i) along the direction of the external electric field, when the electric field intensity was smaller than a certain threshold value; (ii) opposite to the direction of the external electric field, when the electric field intensity was greater than the threshold electric field intensity. The reversal movement of DNA molecules was mainly determined by the competition between the electrophoresis force and the influence of electro-osmosis flow. These new findings will theoretically guide the practical application of fluidic channel sensors and lab-on-chips for precisely manipulating single DNA molecules. Project supported by the National Natural Science Foundation of China (Grant No. 61378083), the International Cooperation Foundation of the National Science and Technology Major Project of the Ministry of Science and Technology of China (Grant No. 2011DFA12220), the Major Research Plan of National Natural Science Foundation of China (Grant No. 91123030), and the Natural Science Foundation of Shaanxi Province of China (Grant Nos. 2010JS110 and 2013SZS03-Z01).

An Estimation of Hybrid Quantum Mechanical Molecular Mechanical Polarization Energies for Small Molecules Using Polarizable Force-Field Approaches

DOE PAGES

Huang, Jing; Mei, Ye; König, Gerhard; ...

2017-01-24

Here in this work, we report two polarizable molecular mechanics (polMM) force field models for estimating the polarization energy in hybrid quantum mechanical molecular mechanical (QM/MM) calculations. These two models, named the potential of atomic charges (PAC) and potential of atomic dipoles (PAD), are formulated from the ab initio quantum mechanical (QM) response kernels for the prediction of the QM density response to an external molecular mechanical (MM) environment (as described by external point charges). The PAC model is similar to fluctuating charge (FQ) models because the energy depends on external electrostatic potential values at QM atomic sites; the PADmore » energy depends on external electrostatic field values at QM atomic sites, resembling induced dipole (ID) models. To demonstrate their uses, we apply the PAC and PAD models to 12 small molecules, which are solvated by TIP3P water. The PAC model reproduces the QM/MM polarization energy with a R 2 value of 0.71 for aniline (in 10,000 TIP3P water configurations) and 0.87 or higher for other eleven solute molecules, while the PAD model has a much better performance with R 2 values of 0.98 or higher. The PAC model reproduces reference QM/MM hydration free energies for 12 solute molecules with a RMSD of 0.59 kcal/mol. The PAD model is even more accurate, with a much smaller RMSD of 0.12 kcal/mol, with respect to the reference. Lastly, this suggests that polarization effects, including both local charge distortion and intramolecular charge transfer, can be well captured by induced dipole type models with proper parametrization.« less

An Estimation of Hybrid Quantum Mechanical Molecular Mechanical Polarization Energies for Small Molecules Using Polarizable Force-Field Approaches.

PubMed

Huang, Jing; Mei, Ye; König, Gerhard; Simmonett, Andrew C; Pickard, Frank C; Wu, Qin; Wang, Lee-Ping; MacKerell, Alexander D; Brooks, Bernard R; Shao, Yihan

2017-02-14

In this work, we report two polarizable molecular mechanics (polMM) force field models for estimating the polarization energy in hybrid quantum mechanical molecular mechanical (QM/MM) calculations. These two models, named the potential of atomic charges (PAC) and potential of atomic dipoles (PAD), are formulated from the ab initio quantum mechanical (QM) response kernels for the prediction of the QM density response to an external molecular mechanical (MM) environment (as described by external point charges). The PAC model is similar to fluctuating charge (FQ) models because the energy depends on external electrostatic potential values at QM atomic sites; the PAD energy depends on external electrostatic field values at QM atomic sites, resembling induced dipole (ID) models. To demonstrate their uses, we apply the PAC and PAD models to 12 small molecules, which are solvated by TIP3P water. The PAC model reproduces the QM/MM polarization energy with a R 2 value of 0.71 for aniline (in 10,000 TIP3P water configurations) and 0.87 or higher for other 11 solute molecules, while the PAD model has a much better performance with R 2 values of 0.98 or higher. The PAC model reproduces reference QM/MM hydration free energies for 12 solute molecules with a RMSD of 0.59 kcal/mol. The PAD model is even more accurate, with a much smaller RMSD of 0.12 kcal/mol, with respect to the reference. This suggests that polarization effects, including both local charge distortion and intramolecular charge transfer, can be well captured by induced dipole type models with proper parametrization.

An Estimation of Hybrid Quantum Mechanical Molecular Mechanical Polarization Energies for Small Molecules Using Polarizable Force-Field Approaches

DOE Office of Scientific and Technical Information (OSTI.GOV)

Huang, Jing; Mei, Ye; König, Gerhard

Here in this work, we report two polarizable molecular mechanics (polMM) force field models for estimating the polarization energy in hybrid quantum mechanical molecular mechanical (QM/MM) calculations. These two models, named the potential of atomic charges (PAC) and potential of atomic dipoles (PAD), are formulated from the ab initio quantum mechanical (QM) response kernels for the prediction of the QM density response to an external molecular mechanical (MM) environment (as described by external point charges). The PAC model is similar to fluctuating charge (FQ) models because the energy depends on external electrostatic potential values at QM atomic sites; the PADmore » energy depends on external electrostatic field values at QM atomic sites, resembling induced dipole (ID) models. To demonstrate their uses, we apply the PAC and PAD models to 12 small molecules, which are solvated by TIP3P water. The PAC model reproduces the QM/MM polarization energy with a R 2 value of 0.71 for aniline (in 10,000 TIP3P water configurations) and 0.87 or higher for other eleven solute molecules, while the PAD model has a much better performance with R 2 values of 0.98 or higher. The PAC model reproduces reference QM/MM hydration free energies for 12 solute molecules with a RMSD of 0.59 kcal/mol. The PAD model is even more accurate, with a much smaller RMSD of 0.12 kcal/mol, with respect to the reference. Lastly, this suggests that polarization effects, including both local charge distortion and intramolecular charge transfer, can be well captured by induced dipole type models with proper parametrization.« less

Weight, gravitation, inertia, and tides

NASA Astrophysics Data System (ADS)

Pujol, Olivier; Lagoute, Christophe; Pérez, José-Philippe

2015-11-01

This paper deals with the factors that influence the weight of an object near the Earth's surface. They are: (1) the Earth's gravitational force, (2) the centrifugal force due to the Earth's diurnal rotation, and (3) tidal forces due to the gravitational field of the Moon and Sun, and other solar system bodies to a lesser extent. Each of these three contributions is discussed and expressions are derived. The relationship between weight and gravitation is thus established in a direct and pedagogical manner readily understandable by undergraduate students. The analysis applies to the Newtonian limit of gravitation. The derivation is based on an experimental (or operational) definition of weight, and it is shown that it coincides with the Earth’s gravitational force modified by diurnal rotation around a polar axis and non-uniformity of external gravitational bodies (tidal term). Two examples illustrate and quantify these modifications, respectively the Eötvös effect and the oceanic tides; tidal forces due to differential gravitation on a spacecraft and an asteroid are also proposed as examples. Considerations about inertia are also given and some comments are made about a widespread, yet confusing, explanation of tides based on a centrifugal force. Finally, the expression of the potential energy of the tide-generating force is established rigorously in the appendix.

Effect of Applied Current Density on Cavitation-Erosion Characteristics for Anodized Al Alloy.

PubMed

Lee, Seung-Jun; Kim, Seong-Jong

2018-02-01

Surface finishing is as important as selection of material to achieve durability. Surface finishing is a process to provide surface with the desired performance and features by applying external forces such as thermal energy or stress. This study investigated the optimum supply current density for preventing from cavitation damages by applying to an anodizing technique that artificially forms on the surface an oxide coating that has excellent mechanical characteristics, such as hardness, wear resistance. Result of hardness test, the greater hardness was associated with greater brittleness, resulting in deleterious characteristics. Consequently, under conditions such as the electrolyte concentration of 10 vol.%, the processing time of 40 min, the electrolyte temperature of 10 °C, and the current density of 20 mA/cm2 were considered to be the optimum anodizing conditions for improvement of durability in seawater.

Ultrasonic/Sonic Mechanisms for Drilling and Coring

NASA Technical Reports Server (NTRS)

Bar-Cohen, Yoseph; Sherrit, Stewart; Dolgin, Benjamin; Askin, Steve; Peterson, Thomas M.; Bell, Bill; Kroh, Jason; Pal, Dharmendra; Krahe, Ron; Du, Shu

2003-01-01

Two apparatuses now under development are intended to perform a variety of deep-drilling, coring, and sensing functions for subsurface exploration of rock and soil. These are modified versions of the apparatuses described in Ultrasonic/Sonic Drill/Corers With Integrated Sensors (NPO-20856), NASA Tech Briefs, Vol. 25, No. 1 (January 2001), page 38. In comparison with the drilling equipment traditionally used in such exploration, these apparatuses weigh less and consume less power. Moreover, unlike traditional drills and corers, these apparatuses function without need for large externally applied axial forces.

Object Imaging Accomplished with an Integrated Circuit Robotic Tactile Sensor Incorporating a Piezoelectric Polyvinylidene Fluoride Thin Film

DTIC Science & Technology

1993-12-01

sensor response. That is, the tactile sensor’s response to a temperature change could be interpreted as the sensor’s response solely to an externally...is a vector quantity. A force acting on a surface can be interpreted in terms of a normal and a tangential component. Often, these components are...polarization [12]: 3-16 h K" + (3.34) Similarly, the stress in a material due to an applied strain and polarization is [12]: T = cS- hTP (3.35) The electric

Solitary waves in the nonlinear Dirac equation in the presence of external driving forces

DOE PAGES

Mertens, Franz G.; Cooper, Fred; Quintero, Niurka R.; ...

2016-01-05

In this paper, we consider the nonlinear Dirac (NLD) equation in (1 + 1) dimensions with scalar–scalar self interaction g 2/κ + 1 (Ψ¯Ψ) κ + 1 in the presence of external forces as well as damping of the form f(x) - iμγ 0Ψ, where both f and Ψ are two-component spinors. We develop an approximate variational approach using collective coordinates (CC) for studying the time dependent response of the solitary waves to these external forces. This approach predicts intrinsic oscillations of the solitary waves, i.e. the amplitude, width and phase all oscillate with the same frequency. The translational motionmore » is also affected, because the soliton position oscillates around a mean trajectory. For κ = 1 we solve explicitly the CC equations of the variational approximation for slow moving solitary waves in a constant external force without damping and find reasonable agreement with solving numerically the CC equations. Finally, we then compare the results of the variational approximation with no damping with numerical simulations of the NLD equation for κ = 1, when the components of the external force are of the form f j = r j exp(–iΚx) and again find agreement if we take into account a certain linear excitation with specific wavenumber that is excited together with the intrinsic oscillations such that the momentum in a transformed NLD equation is conserved.« less

Emergent behavior of cells on microfabricated soft polymeric substrates

NASA Astrophysics Data System (ADS)

Anand, Sandeep Venkit

In recent years, cell based bio-actuators like cardiomyocytes and skeletal muscle cells have emerged as popular choices for powering biological machines consisting of soft polymeric scaffolds at the micro and macro scales. This is owing to their unique ability to generate spontaneous, synchronous contractions either autonomously or under externally applied fields. Most of the biological machine designs reported in literature use single cells or cell clusters conjugated with biocompatible soft polymers like polydimethylsiloxane (PDMS) and hydrogels to produce some form of locomotion by converting chemical energy of the cells to mechanical energy. The mode of locomotion may vary, but the fundamental mechanism that these biological machines exploit to achieve locomotion stems from cell substrate interactions leading to large deformations of the substrates (relative to the cell size). However, the effect of such large scale, dynamic deformation of the substrates on the cellular and cluster level organization of the cells remains elusive. This dissertation tries to explore the emergent behavior of cells on different types of micro-scale deformable, soft polymeric substrates. In the first part of the dissertation, contractile dynamics of primary cardiomyocyte clusters is studied by culturing them on deformable thin polymeric films. The cell clusters beat and generate sufficient forces to deform the substrates out of plane. Over time, the clusters reorient their force dipoles along the direction of maximum compliance. This suggests that the cells are capable of sensing substrate deformations through a mechanosensitive feedback mechanism and dynamically reorganizing themselves. Results are further validated through finite element analysis. The development, characterization and quantification of a novel 1D/2D like polymeric platform for cell culture is presented in the second part. The platform consists of a 2D surface anchoring a long (few millimeters) narrow filament (1D) with a single cell scale (micro scale) cross section. We plate C2C12 cells on the platform and characterize their migration, proliferation, and differentiation patterns in contrast to 2D culture. We find that the cells land on the 2D surface, and then migrate to the filament only when the 2D surface has become nearly confluent. Individual and isolated cells randomly approaching the filament always retract away towards the 2D surface. Once on the filament, their differentiation to myotubes is expedited compared to that on 2D substrate. The myotubes generate periodic twitching forces that deform the filament producing more than 17 um displacement at the tip. Such flagellar motion can be used to develop autonomous micro scale bio-bots. Finally, the design and fabrication of a polymeric micro-pillar based force sensor capable of measuring cellular focal-adhesion forces under externally applied stretch is discussed. The force sensor consists of arrays of uniformly spaced PDMS micro-pillars of 1-2 um diameter and 2-3 um spacing on a macroscale PDMS substrate. The tips of the micro-pillars are selectively patterned with fluorescently labeled ECM proteins using micro-contact printing to promote cell adhesion while simultaneously acting as markers for strain measurements. Cells adhere and spread on top of the pillars causing them to deform. When stretched, the cells reorganize their internal structure and modulate their traction forces in response to the applied stretch. The dynamically varying cellular forces in response to the stretch are computed by measuring the cell induced displacements estimated by isolating the displacements caused by the applied stretch from the net displacements of the tips.

Trends and projections of Southern Hemisphere baroclinicity: the role of external forcing and impact on Australian rainfall

NASA Astrophysics Data System (ADS)

Frederiksen, Carsten S.; Frederiksen, Jorgen S.; Sisson, Janice M.; Osbrough, Stacey L.

2017-05-01

Changes in the characteristics of Southern Hemisphere (SH) storms, in all seasons, during the second half of the twentieth century, have been related to changes in the annual cycle of SH baroclinic instability. In particular, significant negative trends in baroclinic instability, as measured by the Phillips Criterion, have been found in the region of the climatological storm tracks; a zonal band of significant positive trends occur further poleward. Corresponding to this decrease/increase in baroclinic instability there is a decrease/increase in the growth rate of storm formation at these latitudes over this period, and in some cases a preference for storm formation further poleward than normal. Based on model output from a multi-model ensemble (MME) of coupled atmosphere-ocean general circulation models, it is shown that these trends are the result of external radiative forcing, including anthropogenic greenhouse gases, ozone, aerosols and land-use change. The MME is used in an analysis of variance method to separate the internal (natural) variability in the Phillips Criterion from influences associated with anomalous external radiative forcing. In all seasons, the leading externally forced mode has a significant trend and a loading pattern highly correlated with the pattern of trends in the Phillips Criterion. The covariance between the externally forced component of SH rainfall and the leading external mode strongly resembles the MME pattern of SH rainfall trends. A comparison between similar analyses of MME simulations using the second half of the twenty-first century of the Representative Concentration Pathways (RCP) RCP8.5 and RCP4.5 scenarios show that trends in the Phillips Criterion and rainfall are projected to continue and intensify under increasing anthropogenic greenhouse gas concentrations.

Influence of parafunctional loading and prosthetic connection on stress distribution: a 3D finite element analysis.

PubMed

Torcato, Leonardo Bueno; Pellizzer, Eduardo Piza; Verri, Fellippo Ramos; Falcón-Antenucci, Rosse Mary; Santiago Júnior, Joel Ferreira; de Faria Almeida, Daniel Augusto

2015-11-01

Clinicians should consider parafunctional occlusal load when planning treatment. Prosthetic connections can reduce the stress distribution on an implant-supported prosthesis. The purpose of this 3-dimensional finite element study was to assess the influence of parafunctional loading and prosthetic connections on stress distribution. Computer-aided design software was used to construct 3 models. Each model was composed of a bone and an implant (external hexagon, internal hexagon, or Morse taper) with a crown. Finite element analysis software was used to generate the finite element mesh and establish the loading and boundary conditions. A normal force (200-N axial load and 100-N oblique load) and parafunctional force (1000-N axial and 500-N oblique load) were applied. Results were visualized as the maximum principal stress. Three-way analysis of variance and Tukey test were performed, and the percentage of contribution of each variable to the stress concentration was calculated from sum-of squares-analysis. Stress was concentrated around the implant at the cortical bone, and models with the external hexagonal implant showed the highest stresses (P<.001). Oblique loads produced high tensile stress concentrations on the site opposite the load direction. Internal connection implants presented the most favorable biomechanical situation, whereas the least favorable situation was the biomechanical behavior of external connection implants. Parafunctional loading increased the magnitude of stress by 3 to 4 times. Copyright © 2015 Editorial Council for the Journal of Prosthetic Dentistry. Published by Elsevier Inc. All rights reserved.

Anterior stability of the reverse shoulder arthroplasty depending on implant configuration and rotator cuff condition.

PubMed

Pastor, Marc-Frederic; Kraemer, Manuel; Wellmann, Mathias; Hurschler, Christof; Smith, Tomas

2016-11-01

The aim of this study was to investigate the stabilizing influence of the rotator cuff as well as the importance of glenosphere and onlay configuration on the anterior stability of the reverse total shoulder replacement (RTSR). A reverse total shoulder replacement was implanted into eight human cadaveric shoulders, and biomechanical testing was performed under three conditions: after implantation of the RTSR, after additional dissection of the subscapularis tendon, and after additional dissection of the infraspinatus and teres minor tendon. Testing was performed in 30° of abduction and three rotational positions: 30° internal rotation, neutral rotation, and 30° external rotation. Furthermore, the 38-mm and 42-mm glenospheres were tested in combination with a standard and a high-mobility humeral onlay. A gradually increased force was applied to the glenohumeral joint in anterior direction until the RTSR dislocated. The 42-mm glenosphere showed superior stability compared with the 38-mm glenosphere. The standard humeral onlay required significantly higher anterior dislocation forces than the more shallow high-mobility onlay. External rotation was the most stable position. Furthermore, isolated detachment of the subscapularis and combined dissection of the infraspinatus, teres minor, and subscapularis tendon increased anterior instability. This study showed superior stability with the 42-mm glenosphere and the more conforming standard onlay. External rotation was the most stable position. Detachment of the subscapularis as well as dissection of the complete rotator cuff decreased anterior stability.

Parametric study on kink instabilities of twisted magnetic flux ropes in the solar atmosphere

NASA Astrophysics Data System (ADS)

Mei, Z. X.; Keppens, R.; Roussev, I. I.; Lin, J.

2018-01-01

Aims: Twisted magnetic flux ropes (MFRs) in the solar atmosphere have been researched extensively because of their close connection to many solar eruptive phenomena, such as flares, filaments, and coronal mass ejections (CMEs). In this work, we performed a set of 3D isothermal magnetohydrodynamic (MHD) numerical simulations, which use analytical twisted MFR models and study dynamical processes parametrically inside and around current-carrying twisted loops. We aim to generalize earlier findings by applying finite plasma β conditions. Methods: Inside the MFR, approximate internal equilibrium is obtained by pressure from gas and toroidal magnetic fields to maintain balance with the poloidal magnetic field. We selected parameter values to isolate best either internal or external kink instability before studying complex evolutions with mixed characteristics. We studied kink instabilities and magnetic reconnection in MFRs with low and high twists. Results: The curvature of MFRs is responsible for a tire tube force due to its internal plasma pressure, which tends to expand the MFR. The curvature effect of toroidal field inside the MFR leads to a downward movement toward the photosphere. We obtain an approximate internal equilibrium using the opposing characteristics of these two forces. A typical external kink instability totally dominates the evolution of MFR with infinite twist turns. Because of line-tied conditions and the curvature, the central MFR region loses its external equilibrium and erupts outward. We emphasize the possible role of two different kink instabilities during the MFR evolution: internal and external kink. The external kink is due to the violation of the Kruskal-Shafranov condition, while the internal kink requires a safety factor q = 1 surface inside the MFR. We show that in mixed scenarios, where both instabilities compete, complex evolutions occur owing to reconnections around and within the MFR. The S-shaped structures in current distributions appear naturally without invoking flux emergence. Magnetic reconfigurations common to eruptive MFRs and flare loop systems are found in our simulations.

Friction Modifier Using Adherent Metallic Multilayered or Mixed Element Layer Conversion Coatings

NASA Technical Reports Server (NTRS)

Schramm, Harry F. (Inventor); Defalco, Francis G. (Inventor); Starks, Lloyd L., Sr. (Inventor)

2013-01-01

A process for creating conversion coatings and spin, drawing, and extrusion finishes for surfaces, wherein the conversion coatings and spin, drawing, and extrusion finishes contain potassium, phosphorus, nitrogen, and one or more non-alkaline metals and/or one or more metalloids. The process comprises forming an aqueous solution of water, phosphoric acid or sulfuric acid, ammonium hydroxide, an alkali metal hydroxide, and one or more non-alkaline metals and/or one or more metalloids. The aqueous solution forms an anti-friction multilayer conversion and/or mixed element coating or a spin, drawing, and extrusion finish on a surface when applied to the surface, either directly without the use of applied external electromotive force, or as an additive in lubricating fluids.

Transdermal drug delivery: from micro to nano

NASA Astrophysics Data System (ADS)

Pegoraro, Carla; MacNeil, Sheila; Battaglia, Giuseppe

2012-03-01

Delivery across skin offers many advantages compared to oral or intravenous routes of drug administration. Skin however is highly impermeable to most molecules on the basis of size, hydrophilicity, lipophilicity and charge. For this reason it is often necessary to temporarily alter the barrier properties of skin for effective administration. This can be done by applying chemical enhancers, which alter the lipid structure of the top layer of skin (the stratum corneum, SC), by applying external forces such as electric currents and ultrasounds, by bypassing the stratum corneum via minimally invasive microneedles or by using nano-delivery vehicles that can cross and deliver their payload to the deeper layers of skin. Here we present a critical summary of the latest technologies used to increase transdermal delivery.

Surface effects on friction-induced fluid heating in nanochannel flows.

PubMed

Li, Zhigang

2009-02-01

We investigate the mechanism of friction-induced fluid heating under the influence of surfaces. The temperature distributions of liquid argon and helium in nanoscale Poiseuille flows are studied through molecular dynamics simulations. It is found that the fluid heating is mainly caused by the viscous friction in the fluid when the external force is small and there is no slip at the fluid-solid interface. When the external force is larger than the fluid-surface binding force, the friction at the fluid-solid interface dominates over the internal friction of the fluid and is the major contribution to fluid heating. An asymmetric temperature gradient in the fluid is developed in the case of nonidentical walls and the general temperature gradient may change sign as the dominant heating factor changes from internal to interfacial friction with increasing external force. The effect of temperature on the fluid heating is also discussed.

Temperature rise, sea level rise and increased radiative forcing - an application of cointegration methods

NASA Astrophysics Data System (ADS)

Schmith, Torben; Thejll, Peter; Johansen, Søren

2016-04-01

We analyse the statistical relationship between changes in global temperature, global steric sea level and radiative forcing in order to reveal causal relationships. There are in this, however, potential pitfalls due to the trending nature of the time series. We therefore apply a statistical method called cointegration analysis, originating from the field of econometrics, which is able to correctly handle the analysis of series with trends and other long-range dependencies. Further, we find a relationship between steric sea level and temperature and find that temperature causally depends on the steric sea level, which can be understood as a consequence of the large heat capacity of the ocean. This result is obtained both when analyzing observed data and data from a CMIP5 historical model run. Finally, we find that in the data from the historical run, the steric sea level, in turn, is driven by the external forcing. Finally, we demonstrate that combining these two results can lead to a novel estimate of radiative forcing back in time based on observations.

A nonlinear Fokker-Planck equation approach for interacting systems: Anomalous diffusion and Tsallis statistics

NASA Astrophysics Data System (ADS)

Marin, D.; Ribeiro, M. A.; Ribeiro, H. V.; Lenzi, E. K.

2018-07-01

We investigate the solutions for a set of coupled nonlinear Fokker-Planck equations coupled by the diffusion coefficient in presence of external forces. The coupling by the diffusion coefficient implies that the diffusion of each species is influenced by the other and vice versa due to this term, which represents an interaction among them. The solutions for the stationary case are given in terms of the Tsallis distributions, when arbitrary external forces are considered. We also use the Tsallis distributions to obtain a time dependent solution for a linear external force. The results obtained from this analysis show a rich class of behavior related to anomalous diffusion, which can be characterized by compact or long-tailed distributions.

Force-velocity relationship of single actin filament interacting with immobilised myosin measured by electromagnetic technique.

PubMed

Holohan, S-J P; Marston, S B

2005-06-01

The effect of applying an external load to actin filaments moving in the in vitro motility assay is studied. Bead-tailed actin filaments were made by polymerising actin onto 2.8 microm diameter Dynabeads conjugated with gelsolin-G actin. These were introduced into a motility cell coated with 100 microg/ml rabbit fast skeletal myosin in the presence of ATP and 0.5% methylcellulose. The motility cell was inserted between the pole-pieces of an electromagnet and the fluorescent beads and filaments were observed. The force-current relationship of the electromagnet was determined from the velocity of free beads in viscous solution and Stokes' equation. The magnet produced up to 6 pN force on the Dynabeads at 1 A. Many bead-tailed actin filaments stuck to the surface, but the beads that did move moved at the same speed as unloaded f-actin in the same cell. Bead-tailed filaments slowed down under an increasing magnetic load, eventually stalled and then slid backward under increasing load before detaching from the surface. Single-filament force-velocity curves were constructed and a stalling force of about 0.6 pN/mm of actin filament estimated.

Modeling cell-substrate de-adhesion dynamics under fluid shear

NASA Astrophysics Data System (ADS)

Maan, Renu; Rani, Garima; Menon, Gautam I.; Pullarkat, Pramod A.

2018-07-01

Changes in cell-substrate adhesion are believed to signal the onset of cancer metastasis, but such changes must be quantified against background levels of intrinsic heterogeneity between cells. Variations in cell-substrate adhesion strengths can be probed through biophysical measurements of cell detachment from substrates upon the application of an external force. Here, we investigate, theoretically and experimentally, the detachment of cells adhered to substrates when these cells are subjected to fluid shear. We present a theoretical framework within which we calculate the fraction of detached cells as a function of shear stress for fast ramps as well as the decay in this fraction at fixed shear stress as a function of time. Using HEK and 3T3 fibroblast cells as experimental model systems, we extract characteristic force scales for cell adhesion as well as characteristic detachment times. We estimate force-scales of  ∼500 pN associated to a single focal contact, and characteristic time-scales of s representing cell-spread-area dependent mean first passage times to the detached state at intermediate values of the shear stress. Variations in adhesion across cell types are especially prominent when cell detachment is probed by applying a time-varying shear stress. These methods can be applied to characterizing changes in cell adhesion in a variety of contexts, including metastasis.

Effect of deltoid tension and humeral version in reverse total shoulder arthroplasty: a biomechanical study.

PubMed

Henninger, Heath B; Barg, Alexej; Anderson, Andrew E; Bachus, Kent N; Tashjian, Robert Z; Burks, Robert T

2012-04-01

No clear recommendations exist regarding optimal humeral component version and deltoid tension in reverse total shoulder arthroplasty (TSA). A biomechanical shoulder simulator tested humeral versions (0°, 10°, 20° retroversion) and implant thicknesses (-3, 0, +3 mm from baseline) after reverse TSA in human cadavers. Abduction and external rotation ranges of motion as well as abduction and dislocation forces were quantified for native arms and arms implanted with 9 combinations of humeral version and implant thickness. Resting abduction angles increased significantly (up to 30°) after reverse TSA compared with native shoulders. With constant posterior cuff loads, native arms externally rotated 20°, whereas no external rotation occurred in implanted arms (20° net internal rotation). Humeral version did not affect rotational range of motion but did alter resting abduction. Abduction forces decreased 30% vs native shoulders but did not change when version or implant thickness was altered. Humeral center of rotation was shifted 17 mm medially and 12 mm inferiorly after implantation. The force required for lateral dislocation was 60% less than anterior and was not affected by implant thickness or version. Reverse TSA reduced abduction forces compared with native shoulders and resulted in limited external rotation and abduction ranges of motion. Because abduction force was reduced for all implants, the choice of humeral version and implant thickness should focus on range of motion. Lateral dislocation forces were less than anterior forces; thus, levering and inferior/posterior impingement may be a more probable basis for dislocation (laterally) than anteriorly directed forces. Copyright © 2012 Journal of Shoulder and Elbow Surgery Board of Trustees. Published by Mosby, Inc. All rights reserved.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Krasnobaeva, L. A., E-mail: kla1983@mail.ru; Siberian State Medical University Moscowski Trakt 2, Tomsk, 634050; Shapovalov, A. V.

Within the formalism of the Fokker–Planck equation, the influence of nonstationary external force, random force, and dissipation effects on dynamics local conformational perturbations (kink) propagating along the DNA molecule is investigated. Such waves have an important role in the regulation of important biological processes in living systems at the molecular level. As a dynamic model of DNA was used a modified sine-Gordon equation, simulating the rotational oscillations of bases in one of the chains DNA. The equation of evolution of the kink momentum is obtained in the form of the stochastic differential equation in the Stratonovich sense within the frameworkmore » of the well-known McLaughlin and Scott energy approach. The corresponding Fokker–Planck equation for the momentum distribution function coincides with the equation describing the Ornstein–Uhlenbek process with a regular nonstationary external force. The influence of the nonlinear stochastic effects on the kink dynamics is considered with the help of the Fokker– Planck nonlinear equation with the shift coefficient dependent on the first moment of the kink momentum distribution function. Expressions are derived for average value and variance of the momentum. Examples are considered which demonstrate the influence of the external regular and random forces on the evolution of the average value and variance of the kink momentum. Within the formalism of the Fokker–Planck equation, the influence of nonstationary external force, random force, and dissipation effects on the kink dynamics is investigated in the sine–Gordon model. The equation of evolution of the kink momentum is obtained in the form of the stochastic differential equation in the Stratonovich sense within the framework of the well-known McLaughlin and Scott energy approach. The corresponding Fokker–Planck equation for the momentum distribution function coincides with the equation describing the Ornstein–Uhlenbek process with a regular nonstationary external force. The influence of the nonlinear stochastic effects on the kink dynamics is considered with the help of the Fokker–Planck nonlinear equation with the shift coefficient dependent on the first moment of the kink momentum distribution function. Expressions are derived for average value and variance of the momentum. Examples are considered which demonstrate the influence of the external regular and random forces on the evolution of the average value and variance of the kink momentum.« less

Modes of interannual variability in northern hemisphere winter atmospheric circulation in CMIP5 models: evaluation, projection and role of external forcing

NASA Astrophysics Data System (ADS)

Frederiksen, Carsten S.; Ying, Kairan; Grainger, Simon; Zheng, Xiaogu

2018-04-01

Models from the coupled model intercomparison project phase 5 (CMIP5) dataset are evaluated for their ability to simulate the dominant slow modes of interannual variability in the Northern Hemisphere atmospheric circulation 500 hPa geopotential height in the twentieth century. A multi-model ensemble of the best 13 models has then been used to identify the leading modes of interannual variability in components related to (1) intraseasonal processes; (2) slowly-varying internal dynamics; and (3) the slowly-varying response to external changes in radiative forcing. Modes in the intraseasonal component are related to intraseasonal variability in the North Atlantic, North Pacific and North American, and Eurasian regions and are little affected by the larger radiative forcing of the Representative Concentration Pathways 8.5 (RCP8.5) scenario. The leading modes in the slow-internal component are related to the El Niño-Southern Oscillation, Pacific North American or Tropical Northern Hemisphere teleconnection, the North Atlantic Oscillation, and the Western Pacific teleconnection pattern. While the structure of these slow-internal modes is little affected by the larger radiative forcing of the RCP8.5 scenario, their explained variance increases in the warmer climate. The leading mode in the slow-external component has a significant trend and is shown to be related predominantly to the climate change trend in the well mixed greenhouse gas concentration during the historical period. This mode is associated with increasing height in the 500 hPa pressure level. A secondary influence on this mode is the radiative forcing due to stratospheric aerosols associated with volcanic eruptions. The second slow-external mode is shown to be also related to radiative forcing due to stratospheric aerosols. Under RCP8.5 there is only one slow-external mode related to greenhouse gas forcing with a trend over four times the historical trend.

In situ forces and length patterns of the fibular collateral ligament under controlled loading: an in vitro biomechanical study using a robotic system.

PubMed

Liu, Ping; Wang, Jianquan; Xu, Yan; Ao, Yingfang

2015-04-01

The aim of this study was to determine the in situ forces and length patterns of the fibular collateral ligament (FCL) and kinematics of the knee under various loading conditions. Six fresh-frozen cadaveric knees were used (mean age 46 ± 14.4 years; range 20-58). In situ forces and length patterns of FCL and kinematics of the knee were determined under the following loading conditions using a robotic/universal force-moment sensor testing system: no rotation, varus (10 Nm), external rotation (5 Nm), and internal rotation (5 Nm) at 0°, 15°, 30°, 60º, 90°, and 120° of flexion, respectively. Under no rotation loading, the distances between the centres of the FCL attachments decreased as the knee flexed. Under varus loading, the force in FCL peaked at 15° of flexion and decreased with further knee flexion, while distances remained nearly constant and the varus rotation increased with knee flexion. Using external rotation, the force in the FCL also peaked at 15° flexion and decreased with further knee flexion, the distances decreased with flexion, and external rotation increased with knee flexion. Using internal rotation load, the force in the FCL was relatively small across all knee flexion angles, and the distances decreased with flexion; the amount of internal rotation was fairly constant. FCL has a primary role in preventing varus and external rotation at 15° of flexion. The FCL does not perform isometrically following knee flexion during neutral rotation, and tibia rotation has significant effects on the kinematics of the FCL. Varus and external rotation laxity increased following knee flexion. By providing more realistic data about the function and length patterns of the FCL and the kinematics of the intact knee, improved reconstruction and rehabilitation protocols can be developed.

[Present situation and development trends of asymmetrical flow field-flow fractionation].

PubMed

Liang, Qihui; Wu, Di; Qiu, Bailing; Han, Nanyin

2017-09-08

Field-flow fractionation (FFF) is a kind of mature separation technologies in the field of bioanalysis, feasible of separating analytes with the differences of certain physical and chemical properties by the combination effects of two orthogonal force fields (flow field and external force field). Asymmetrical flow field-flow fractionation (AF4) is a vital subvariant of FFF, which applying a vertical flow field as the second dimension force field. The separation in AF4 opening channel is carried out by any composition carrier fluid, universally and effectively used in separation of bioparticles and biopolymers due to the non-invasivity feature. Herein, bio-analytes are held in bio-friendly environment and easily sterilized without using degrading carrier fluid which is conducive to maintain natural conformation. In this review, FFF and AF4 principles are briefly described, and some classical and emerging applications and developments in the bioanalytical fields are concisely introduced and tabled. Also, special focus is given to the hyphenation of AF4 with highly specific, sensitive detection technologies.

Mechanosensing drives acuity of αβ T-cell recognition

PubMed Central

Feng, Yinnian; Brazin, Kristine N.; Kobayashi, Eiji; Mallis, Robert J.; Reinherz, Ellis L.; Lang, Matthew J.

2017-01-01

T lymphocytes use surface αβ T-cell receptors (TCRs) to recognize peptides bound to MHC molecules (pMHCs) on antigen-presenting cells (APCs). How the exquisite specificity of high-avidity T cells is achieved is unknown but essential, given the paucity of foreign pMHC ligands relative to the ubiquitous self-pMHC array on an APC. Using optical traps, we determine physicochemical triggering thresholds based on load and force direction. Strikingly, chemical thresholds in the absence of external load require orders of magnitude higher pMHC numbers than observed physiologically. In contrast, force applied in the shear direction (∼10 pN per TCR molecule) triggers T-cell Ca2+ flux with as few as two pMHC molecules at the interacting surface interface with rapid positional relaxation associated with similarly directed motor-dependent transport via ∼8-nm steps, behaviors inconsistent with serial engagement during initial TCR triggering. These synergistic directional forces generated during cell motility are essential for adaptive T-cell immunity against infectious pathogens and cancers. PMID:28811364

Ratchet Effects in Active Matter Systems

DOE PAGES

Reichhardt, Cynthia Jane; Reichhardt, Charles

2016-12-21

Ratchet effects can arise for single or collectively interacting Brownian particles on an asymmetric substrate when a net dc transport is produced by an externally applied ac driving force or by periodically flashing the substrate. Recently, a new class of active ratchet systems that do not require the application of external driving has been realized through the use of active matter; they are self-propelled units that can be biological or nonbiological in nature. When active materials such as swimming bacteria interact with an asymmetric substrate, a net dc directed motion can arise even without external driving, opening a wealth ofmore » possibilities such as sorting, cargo transport, or micromachine construction. We review the current status of active matter ratchets for swimming bacteria, cells, active colloids, and swarming models, focusing on the role of particle-substrate interactions. Here, we describe ratchet reversals produced by collective effects and the use of active ratchets to transport passive particles. We discuss future directions including deformable substrates or particles, the role of different swimming modes, varied particle–particle interactions, and nondissipative effects.« less

Magnetic targeting of nanoparticles across the intact blood–brain barrier

PubMed Central

Kong, Seong Deok; Lee, Jisook; Ramachandran, Srinivasan; Eliceiri, Brian P.; Shubayev, Veronica I.; Lal, Ratnesh; Jin, Sungho

2015-01-01

Delivery of therapeutic or diagnostic agents across an intact blood–brain barrier (BBB) remains a major challenge. Here we demonstrate in a mouse model that magnetic nanoparticles (MNPs) can cross the normal BBB when subjected to an external magnetic field. Following a systemic administration, an applied external magnetic field mediates the ability of MNPs to permeate the BBB and accumulate in a perivascular zone of the brain parenchyma. Direct tracking and localization inside endothelial cells and in the perivascular extracellular matrix in vivo was established using fluorescent MNPs. These MNPs were inert and associated with low toxicity, using a non-invasive reporter for astrogliosis, biochemical and histological studies. Atomic force microscopy demonstrated that MNPs were internalized by endothelial cells, suggesting that trans-cellular trafficking may be a mechanism for the MNP crossing of the BBB observed. The silica-coated magnetic nanocapsules (SiMNCs) allow on-demand drug release via remote radio frequency (RF) magnetic field. Together, these results establish an effective strategy for regulating the biodistribution of MNPs in the brain through the application of an external magnetic field. PMID:23063548

Controlling Two-dimensional Tethered Vesicle Motion Using an Electric Field

PubMed Central

Yoshina-Ishii, Chiaki; Boxer, Steven G.

2008-01-01

We recently introduced methods to tether phospholipid vesicles or proteoliposomes onto a fluid supported lipid bilayer using DNA hybridization. These intact tethered vesicles diffuse in two dimensions parallel to the supporting membrane surface. In this paper, we report the dynamic response of individual tethered vesicles to an electric field applied parallel to the bilayer surface. Vesicles respond to the field by moving in the direction of electro-osmotic flow, and this can be used to reversibly concentrate tethered vesicles against a barrier. By adding increasing amounts of negatively charged phosphatidylserine to the supporting bilayer to increase electro-osmosis, the electrophoretic mobility of the tethered vesicles can be increased. The electro-osmotic contribution can be modeled well by a sphere connected to a cylindrical anchor in a viscous membrane with charged head groups. The electrophoretic force on the negatively charged tethered vesicles opposes the electro-osmotic force. By increasing the amount of negative charge on the tethered vesicle, drift in the direction of electro-osmotic flow can be slowed; at high negative charge on the tethered vesicle, motion can be forced in the direction of electrophoresis. The balance between these forces can be visualized on a patterned supporting bilayer containing negatively charged lipids which themselves reorganize in an externally applied electric field to create a gradient of charge within a corralled region. The charge gradient at the surface creates a gradient of electro-osmotic flow, and vesicles carrying similar amounts of negative charge can be focused to a region perpendicular to the applied field where electrophoresis is balanced by electro-osmosis, away from the corral boundary. Electric fields are effective tools to direct tethered vesicles, concentrate them and to measure the tethered vesicle’s electrostatic properties. PMID:16489833

Optical quantification of forces at play during stem cell differentiation

NASA Astrophysics Data System (ADS)

Ritter, Christine M.; Brickman, Joshua M.; Oddershede, Lene B.

2016-03-01

A cell is in constant interaction with its environment, it responds to external mechanical, chemical and biological signals. The response to these signals can be of various nature, for instance intra-cellular mechanical re-arrangements, cell-cell interactions, or cellular reinforcements. Optical methods are quite attractive for investigating the mechanics inside living cells as, e.g., optical traps are amongst the only nanotools that can reach and manipulate, measure forces, inside a living cell. In the recent years it has become increasingly evident that not only biochemical and biomolecular cues, but also that mechanical ones, play an important roles in stem cell differentiation. The first evidence for the importance of mechanical cues emerged from studies showing that substrate stiffness had an impact on stem cell differentiation. Recently, techniques such as optical tweezers and stretchers have been applied to stem cells, producing new insights into the role of mechanics in regulating renewal and differentiation. Here, we describe how optical tweezers and optical stretchers can be applied as a tool to investigate stem cell mechanics and some of the recent results to come out of this work.

Periodic modulation-based stochastic resonance algorithm applied to quantitative analysis for weak liquid chromatography-mass spectrometry signal of granisetron in plasma

NASA Astrophysics Data System (ADS)

Xiang, Suyun; Wang, Wei; Xiang, Bingren; Deng, Haishan; Xie, Shaofei

2007-05-01

The periodic modulation-based stochastic resonance algorithm (PSRA) was used to amplify and detect the weak liquid chromatography-mass spectrometry (LC-MS) signal of granisetron in plasma. In the algorithm, the stochastic resonance (SR) was achieved by introducing an external periodic force to the nonlinear system. The optimization of parameters was carried out in two steps to give attention to both the signal-to-noise ratio (S/N) and the peak shape of output signal. By applying PSRA with the optimized parameters, the signal-to-noise ratio of LC-MS peak was enhanced significantly and distorted peak shape that often appeared in the traditional stochastic resonance algorithm was corrected by the added periodic force. Using the signals enhanced by PSRA, this method extended the limit of detection (LOD) and limit of quantification (LOQ) of granisetron in plasma from 0.05 and 0.2 ng/mL, respectively, to 0.01 and 0.02 ng/mL, and exhibited good linearity, accuracy and precision, which ensure accurate determination of the target analyte.

Orientational ordering of colloidal dispersions by application of time-dependent external forces.

PubMed

Moths, Brian; Witten, T A

2013-08-01

We discuss a method of organizing incoherent motion of a colloidal suspension to produce synchronized, coherent motion, extending the discussion of our recent Letter [Moths and Witten, Phys. Rev. Lett. 110, 028301 (2013)]. The method does not require interaction between the objects. Instead, the effect is controlled by the "twist matrix" which gives the angular velocity of an asymmetric object in a fluid resulting from a weak external force. We analyze the two types of forcing considered in the Letter: a force alternating between two directions and a continuously rotating force. For the alternating force, we justify the claim of the Letter that under appropriate forcing conditions, the orientational entropy of the objects decreases indefinitely with time, on average. We provide a bound on that rate in terms of the twist matrix. For the case of rotating force, we derive conditions for phased-locked motion of the objects to the force and prove that there is only one stable phase-locked orientation under these conditions. We find numerically that the fastest alignment typically occurs for tilt angles of order unity. We discuss how the alignment effect scales with the object size for external forcing caused by gravity or an electric field. Under practical forcing conditions we estimate that the alignment should persist despite rotational diffusion for objects larger than about 10 microns. Potential misalignment owing to hydrodynamic interaction of the objects is estimated to be negligible at volume fractions smaller than about 10(-4.5) (10(-3)) when the forcing is gravitational (electrophoretic).

External Source of Infection and Nutritional Efficiency Control Chaos in a Predator-Prey Model with Disease in the Predator

NASA Astrophysics Data System (ADS)

Pada Das, Krishna; Roy, Prodip; Ghosh, Subhabrata; Maiti, Somnath

This paper deals with an eco-epidemiological approach with disease circulating through the predator species. Disease circulation in the predator species can be possible by contact as well as by external sources. Here, we try to discuss the role of external source of infection along with nutritional value on system dynamics. To establish our findings, we have worked out the local and global stability analysis of the equilibrium points with Hopf bifurcation analysis associated with interior equilibrium point. The ecological consequence by ecological basic reproduction number as well as the disease basic reproduction number or basic reproductive ratio are obtained and we have analyzed the community structure of the particular system with the help of ecological and disease basic reproduction numbers. Further we pay attention to the chaotic dynamics which is produced by disease circulating in predator species by contact. Our numerical simulations reveal that eco-epidemiological system without external source of infection induced chaotic dynamics for increasing force of infection due to contact, whereas in the presence of external source of infection, it exhibits stable solution. It is also observed that nutritional value can prevent chaotic dynamics. We conclude that chaotic dynamics can be controlled by the external source of infection as well as nutritional value. We apply basic tools of nonlinear dynamics such as Poincare section and maximum Lyapunov exponent to investigate chaotic behavior of the system.

External Influences on Modeled and Observed Cloud Trends

NASA Technical Reports Server (NTRS)

Marvel, Kate; Zelinka, Mark; Klein, Stephen A.; Bonfils, Celine; Caldwell, Peter; Doutriaux, Charles; Santer, Benjamin D.; Taylor, Karl E.

2015-01-01

Understanding the cloud response to external forcing is a major challenge for climate science. This crucial goal is complicated by intermodel differences in simulating present and future cloud cover and by observational uncertainty. This is the first formal detection and attribution study of cloud changes over the satellite era. Presented herein are CMIP5 (Coupled Model Intercomparison Project - Phase 5) model-derived fingerprints of externally forced changes to three cloud properties: the latitudes at which the zonally averaged total cloud fraction (CLT) is maximized or minimized, the zonal average CLT at these latitudes, and the height of high clouds at these latitudes. By considering simultaneous changes in all three properties, the authors define a coherent multivariate fingerprint of cloud response to external forcing and use models from phase 5 of CMIP (CMIP5) to calculate the average time to detect these changes. It is found that given perfect satellite cloud observations beginning in 1983, the models indicate that a detectable multivariate signal should have already emerged. A search is then made for signals of external forcing in two observational datasets: ISCCP (International Satellite Cloud Climatology Project) and PATMOS-x (Advanced Very High Resolution Radiometer (AVHRR) Pathfinder Atmospheres - Extended). The datasets are both found to show a poleward migration of the zonal CLT pattern that is incompatible with forced CMIP5 models. Nevertheless, a detectable multivariate signal is predicted by models over the PATMOS-x time period and is indeed present in the dataset. Despite persistent observational uncertainties, these results present a strong case for continued efforts to improve these existing satellite observations, in addition to planning for new missions.

A thermostatted kinetic theory model for event-driven pedestrian dynamics

NASA Astrophysics Data System (ADS)

Bianca, Carlo; Mogno, Caterina

2018-06-01

This paper is devoted to the modeling of the pedestrian dynamics by means of the thermostatted kinetic theory. Specifically the microscopic interactions among pedestrians and an external force field are modeled for simulating the evacuation of pedestrians from a metro station. The fundamentals of the stochastic game theory and the thermostatted kinetic theory are coupled for the derivation of a specific mathematical model which depicts the time evolution of the distribution of pedestrians at different exits of a metro station. The perturbation theory is employed in order to establish the stability analysis of the nonequilibrium stationary states in the case of a metro station consisting of two exits. A general sensitivity analysis on the initial conditions, the magnitude of the external force field and the number of exits is presented by means of numerical simulations which, in particular, show how the asymptotic distribution and the convergence time are affected by the presence of an external force field. The results show how, in evacuation conditions, the interaction dynamics among pedestrians can be negligible with respect to the external force. The important role of the thermostat term in allowing the reaching of the nonequilibrium stationary state is stressed out. Research perspectives are underlined at the end of paper, in particular for what concerns the derivation of frameworks that take into account the definition of local external actions and the introduction of the space and velocity dynamics.

Non-cooperative Brownian donkeys: A solvable 1D model

NASA Astrophysics Data System (ADS)

Jiménez de Cisneros, B.; Reimann, P.; Parrondo, J. M. R.

2003-12-01

A paradigmatic 1D model for Brownian motion in a spatially symmetric, periodic system is tackled analytically. Upon application of an external static force F the system's response is an average current which is positive for F < 0 and negative for F > 0 (absolute negative mobility). Under suitable conditions, the system approaches 100% efficiency when working against the external force F.

Regularity in an environment produces an internal torque pattern for biped balance control.

PubMed

Ito, Satoshi; Kawasaki, Haruhisa

2005-04-01

In this paper, we present a control method for achieving biped static balance under unknown periodic external forces whose periods are only known. In order to maintain static balance adaptively in an uncertain environment, it is essential to have information on the ground reaction forces. However, when the biped is exposed to a steady environment that provides an external force periodically, uncertain factors on the regularity with respect to a steady environment are gradually clarified using learning process, and finally a torque pattern for balancing motion is acquired. Consequently, static balance is maintained without feedback from ground reaction forces and achieved in a feedforward manner.

Behavior of medial gastrocnemius motor units during postural reactions to external perturbations after stroke.

PubMed

Pollock, C L; Ivanova, T D; Hunt, M A; Garland, S J

2015-10-01

This study investigated the behavior of medial gastrocnemius (GM) motor units (MU) during external perturbations in standing in people with chronic stroke. GM MUs were recorded in standing while anteriorly-directed perturbations were introduced by applying loads of 1% body mass (BM) at the pelvis every 25-40s until 5% BM was maintained. Joint kinematics, surface electromyography (EMG), and force platform measurements were assessed. Although external loads caused a forward progression of the anterior-posterior centre of pressure (APCOP), people with stroke decreased APCOP velocity and centre of mass (COM) velocity immediately following the highest perturbations, thereby limiting movement velocity in response to perturbations. MU firing rate did not increase with loading but the GM EMG magnitude increased, reflecting MU recruitment. MU inter spike interval (ISI) during the dynamic response was negatively correlated with COM velocity and hip angular velocity. The GM utilized primarily MU recruitment to maintain standing during external perturbations. The lack of MU firing rate modulation occurred with a change in postural central set. However, the relationship of MU firing rate with kinematic variables suggests underlying long-loop responses may be somewhat intact after stroke. People with stroke demonstrate alterations in postural control strategies which may explain MU behavior with external perturbations. Copyright © 2014 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.

Triggered dynamics in a model of different fault creep regimes

PubMed Central

Kostić, Srđan; Franović, Igor; Perc, Matjaž; Vasović, Nebojša; Todorović, Kristina

2014-01-01

The study is focused on the effect of transient external force induced by a passing seismic wave on fault motion in different creep regimes. Displacement along the fault is represented by the movement of a spring-block model, whereby the uniform and oscillatory motion correspond to the fault dynamics in post-seismic and inter-seismic creep regime, respectively. The effect of the external force is introduced as a change of block acceleration in the form of a sine wave scaled by an exponential pulse. Model dynamics is examined for variable parameters of the induced acceleration changes in reference to periodic oscillations of the unperturbed system above the supercritical Hopf bifurcation curve. The analysis indicates the occurrence of weak irregular oscillations if external force acts in the post-seismic creep regime. When fault motion is exposed to external force in the inter-seismic creep regime, one finds the transition to quasiperiodic- or chaos-like motion, which we attribute to the precursory creep regime and seismic motion, respectively. If the triggered acceleration changes are of longer duration, a reverse transition from inter-seismic to post-seismic creep regime is detected on a larger time scale. PMID:24954397

[Characteristics of electroosmotic flow in open-tubular capillary electrochromatography with magnetic nanoparticle coating as mixed-mode stationary phase].

PubMed

Qin, Sasa; Zhou, Chaoran; Zhu, Yaxian; Ren, Zhiyu; Zhang, Lingyi; Fu, Honggang; Zhang, Weibing

2011-09-01

A novel open-tubular capillary electrochromatography (OT-CEC) column with magnetic nanoparticle coating as mixed-mode stationary phase was prepared. The mixed-mode stationary phases were obtained by mixing C18 and amino modified magnetic nanoparticles with different ratios. The mixed modified magnetic nanoparticles as stationary phase were introduced into the capillary by using external magnetic force. The magnetic nanoparticle coating can be easily regenerated by removing the external magnetic field, and applied to other separation modes. The characteristics of electroosmotic flow (EOF) were theoretically investigated through the effect of physicochemical properties of different stationary phases on EOF. The experiment was conducted under different ratios of mixed-mode stationary phases and coating lengths, and it was verified that the theoretical conclusions accorded with the experimental results. It was shown that the EOF can be easily adjusted by changing the ratio of stationary phases or the number of permanent magnets.

ROCOPT: A user friendly interactive code to optimize rocket structural components

NASA Technical Reports Server (NTRS)

Rule, William K.

1989-01-01

ROCOPT is a user-friendly, graphically-interfaced, microcomputer-based computer program (IBM compatible) that optimizes rocket components by minimizing the structural weight. The rocket components considered are ring stiffened truncated cones and cylinders. The applied loading is static, and can consist of any combination of internal or external pressure, axial force, bending moment, and torque. Stress margins are calculated by means of simple closed form strength of material type equations. Stability margins are determined by approximate, orthotropic-shell, closed-form equations. A modified form of Powell's method, in conjunction with a modified form of the external penalty method, is used to determine the minimum weight of the structure subject to stress and stability margin constraints, as well as user input constraints on the structural dimensions. The graphical interface guides the user through the required data prompts, explains program options and graphically displays results for easy interpretation.

A self-assembled nanoscale robotic arm controlled by electric fields

NASA Astrophysics Data System (ADS)

Kopperger, Enzo; List, Jonathan; Madhira, Sushi; Rothfischer, Florian; Lamb, Don C.; Simmel, Friedrich C.

2018-01-01

The use of dynamic, self-assembled DNA nanostructures in the context of nanorobotics requires fast and reliable actuation mechanisms. We therefore created a 55-nanometer–by–55-nanometer DNA-based molecular platform with an integrated robotic arm of length 25 nanometers, which can be extended to more than 400 nanometers and actuated with externally applied electrical fields. Precise, computer-controlled switching of the arm between arbitrary positions on the platform can be achieved within milliseconds, as demonstrated with single-pair Förster resonance energy transfer experiments and fluorescence microscopy. The arm can be used for electrically driven transport of molecules or nanoparticles over tens of nanometers, which is useful for the control of photonic and plasmonic processes. Application of piconewton forces by the robot arm is demonstrated in force-induced DNA duplex melting experiments.

Pressure vessel bottle mount

NASA Technical Reports Server (NTRS)

Wingett, Paul (Inventor)

2001-01-01

A mounting assembly for mounting a composite pressure vessel to a vehicle includes a saddle having a curved surface extending between two pillars for receiving the vessel. The saddle also has flanged portions which can be bolted to the vehicle. Each of the pillars has hole in which is mounted the shaft portion of an attachment member. A resilient member is disposed between each of the shaft portions and the holes and loaded by a tightening nut. External to the holes, each of the attachment members has a head portion to which a steel band is attached. The steel band circumscribes the vessel and translates the load on the springs into a clamping force on the vessel. As the vessel expands and contracts, the resilient members expand and contract so that the clamping force applied by the band to the vessel remains constant.

Relativistic theory of tidal Love numbers

DOE Office of Scientific and Technical Information (OSTI.GOV)

Binnington, Taylor; Poisson, Eric

In Newtonian gravitational theory, a tidal Love number relates the mass multipole moment created by tidal forces on a spherical body to the applied tidal field. The Love number is dimensionless, and it encodes information about the body's internal structure. We present a relativistic theory of Love numbers, which applies to compact bodies with strong internal gravities; the theory extends and completes a recent work by Flanagan and Hinderer, which revealed that the tidal Love number of a neutron star can be measured by Earth-based gravitational-wave detectors. We consider a spherical body deformed by an external tidal field, and providemore » precise and meaningful definitions for electric-type and magnetic-type Love numbers; and these are computed for polytropic equations of state. The theory applies to black holes as well, and we find that the relativistic Love numbers of a nonrotating black hole are all zero.« less

Electrowetting of Weak Polyelectrolyte-Coated Surfaces.

PubMed

Sénéchal, Vincent; Saadaoui, Hassan; Rodriguez-Hernandez, Juan; Drummond, Carlos

2017-05-23

Polymer coatings are commonly used to modify interfacial properties like wettability, lubrication, or biocompatibility. These properties are determined by the conformation of polymer molecules at the interface. Polyelectrolytes are convenient elementary bricks to build smart materials, given that polyion chain conformation is very sensitive to different environmental variables. Here we discuss the effect of an applied electric field on the properties of surfaces coated with poly(acrylic acid) brushes. By combining atomic force microscopy, quartz crystal microbalance, and contact angle experiments, we show that it is possible to precisely tune polyion chain conformation, surface adhesion, and surface wettability using very low applied voltages if the polymer grafting density and environmental conditions (pH and ionic strength) are properly formulated. Our results indicate that the effective ionization degree of the grafted weak polyacid can be finely controlled with the externally applied field, with important consequences for the macroscopic surface properties.

The onset of chaos in orbital pilot-wave dynamics.

PubMed

Tambasco, Lucas D; Harris, Daniel M; Oza, Anand U; Rosales, Rodolfo R; Bush, John W M

2016-10-01

We present the results of a numerical investigation of the emergence of chaos in the orbital dynamics of droplets walking on a vertically vibrating fluid bath and acted upon by one of the three different external forces, specifically, Coriolis, Coulomb, or linear spring forces. As the vibrational forcing of the bath is increased progressively, circular orbits destabilize into wobbling orbits and eventually chaotic trajectories. We demonstrate that the route to chaos depends on the form of the external force. When acted upon by Coriolis or Coulomb forces, the droplet's orbital motion becomes chaotic through a period-doubling cascade. In the presence of a central harmonic potential, the transition to chaos follows a path reminiscent of the Ruelle-Takens-Newhouse scenario.

Nonstationary time series prediction combined with slow feature analysis

NASA Astrophysics Data System (ADS)

Wang, G.; Chen, X.

2015-01-01

Almost all climate time series have some degree of nonstationarity due to external driving forces perturbations of the observed system. Therefore, these external driving forces should be taken into account when reconstructing the climate dynamics. This paper presents a new technique of combining the driving force of a time series obtained using the Slow Feature Analysis (SFA) approach, then introducing the driving force into a predictive model to predict non-stationary time series. In essence, the main idea of the technique is to consider the driving forces as state variables and incorporate them into the prediction model. To test the method, experiments using a modified logistic time series and winter ozone data in Arosa, Switzerland, were conducted. The results showed improved and effective prediction skill.

Experimental studies of protozoan response to intense magnetic fields and forces

NASA Astrophysics Data System (ADS)

Guevorkian, Karine

Intense static magnetic fields of up to 31 Tesla were used as a novel tool to manipulate the swimming mechanics of unicellular organisms. It is shown that homogenous magnetic fields alter the swimming trajectories of the single cell protozoan Paramecium caudatum, by aligning them parallel to the applied field. Immobile neutrally buoyant paramecia also oriented in magnetic fields with similar rates as the motile ones. It was established that the magneto-orientation is mostly due to the magnetic torques acting on rigid structures in the cell body and therefore the response is a non-biological, passive response. From the orientation rate of paramecia in various magnetic field strengths, the average anisotropy of the diamagnetic susceptibility of the cell was estimated. It has also been demonstrated that magnetic forces can be used to create increased, decreased and even inverted simulated gravity environments for the investigation of the gravi-responses of single cells. Since the mechanisms by which Earth's gravity affects cell functioning are still not fully understood, a number of methods to simulate different strength gravity environments, such as centrifugation, have been employed. Exploiting the ability to exert magnetic forces on weakly diamagnetic constituents of the cells, we were able to vary the gravity from -8 g to 10 g, where g is Earth's gravity. Investigations of the swimming response of paramecia in these simulated gravities revealed that they actively regulate their swimming speed to oppose the external force. This result is in agreement with centrifugation experiments, confirming the credibility of the technique. Moreover, the Paramecium's swimming ceased in simulated gravity of 10 g, indicating a maximum possible propulsion force of 0.7 nN. The magnetic force technique to simulate gravity is the only earthbound technique that can create increased and decreased simulated gravities in the same experimental setup. These findings establish a general technique for applying continuously variable forces to cells or cell populations suitable for exploring their force transduction mechanisms.

Kinetics of the Multistep Rupture of Fibrin ‘A-a’ Polymerization Interactions Measured Using Atomic Force Microscopy

PubMed Central

Averett, Laurel E.; Schoenfisch, Mark H.; Akhremitchev, Boris B.; Gorkun, Oleg V.

2009-01-01

Abstract Fibrin, the structural scaffold of blood clots, spontaneously polymerizes through the formation of ‘A-a’ knob-hole bonds. When subjected to external force, the dissociation of this bond is accompanied by two to four abrupt changes in molecular dimension observable as rupture events in a force curve. Herein, the configuration, molecular extension, and kinetic parameters of each rupture event are examined. The increases in contour length indicate that the D region of fibrinogen can lengthen by ∼50% of the length of a fibrin monomer before rupture of the ‘A-a’ interaction. The dependence of the dissociation rate on applied force was obtained using probability distributions of rupture forces collected at different pull-off velocities. These distributions were fit using a model in which the effects of the shape of the binding potential are used to quantify the kinetic parameters of forced dissociation. We found that the weak initial rupture (i.e., event 1) was not well approximated by these models. The ruptured bonds comprising the strongest ruptures, events 2 and 3, had kinetic parameters similar to those commonly found for the mechanical unfolding of globular proteins. The bonds ruptured in event 4 were well described by these analyses, but were more loosely bound than the bonds in events 2 and 3. We propose that the first event represents the rupture of an unknown interaction parallel to the ‘A-a’ bond, events 2 and 3 represent unfolding of structures in the D region of fibrinogen, and event 4 is the rupture of the ‘A-a’ knob-hole bond weakened by prior structural unfolding. Comparison of the activation energy obtained via force spectroscopy measurements with the thermodynamic free energy of ‘A-a’ bond dissociation indicates that the ‘A-a’ bond may be more resistant to rupture by applied force than to rupture by thermal dissociation. PMID:19917237

An allosterically regulated reversible mechanical molecular switch: A de novo protein maquette functions as a redox/ionic strength sensor coupling chemical binding energy or charge interactions to conformational change

NASA Astrophysics Data System (ADS)

Grosset, Anne Marie

2000-10-01

Switch-like structural rearrangements of subunits due to charge-interactions are common in the basic biological action of proteins that couple and transfer chemical and ionic signals, sensing and regulation, mechanical force and electrochemical free energy. A simple synthetic protein model (maquette) has been designed to better understand the engineering of natural switches. Basic thermodynamic principles define the two key elements required for biological or chemical function of a switch. First, there must be two well-defined states. In this case, the two conformational states must have an energetic difference (DeltaDeltaG°) that is spanned by the applied driving force. Second, there must be an external stimulus, which preferentially interacts with one of the two states. The external stimulus provides the driving force that shifts the equilibrium from the first state to the second state (≥10:1 shifting towards ≤1:10). The energetic difference between the states must be the same order of magnitude as the driving force. In this synthetic protein, the two conformational states correspond to parallel (syn) and antiparallel (anti) assembly of the two identical helix-ss-helix subunits that bind heme close to the di-sulfide loop region. Charge interactions between two ferric hemes bound to histidines provide a driving force on the order of 2 kcal/mol (corresponding in the syn-topology to the 75--100 mV split in the heme redox potentials, or the 25--80 times weaker binding for the second ferric heme). The tetra-alpha-helix bundle has been modified to have a DeltaG around 1.8--2.5 kcal/mol (a 50--80 fold difference in the anti/syn ratio). Therefore, oxidation and reduction of the heme, or the binding of a second charged ferric heme can reversibly switch between syn- and anti-topologies, providing a sensitive detector of redox state or heme concentration. External solution conditions (e.g. ionic composition) can act on the protein remotely from the primary internal switch action and confer a secondary level of allosteric regulation. Bifunctional ligands can link subunits to shift topology. Scanning redox potentiometry can monitor the kinetics of topological change. Point amino acid substitutions and computer repacking of the hydrophobic core can modulate both the kinetics and the energetics.

A bioreactor test system to mimic the biological and mechanical environment of oral soft tissues and to evaluate substitutes for connective tissue grafts.

PubMed

Mathes, Stephanie H; Wohlwend, Lorenz; Uebersax, Lorenz; von Mentlen, Roger; Thoma, Daniel S; Jung, Ronald E; Görlach, Christoph; Graf-Hausner, Ursula

2010-12-15

Gingival cells of the oral connective tissue are exposed to complex mechanical forces during mastication, speech, tooth movement and orthodontic treatments. Especially during wound healing following surgical procedures, internal and external forces may occur, creating pressure upon the newly formed tissue. This clinical situation has to be considered when developing biomaterials to augment soft tissue in the oral cavity. In order to pre-evaluate a collagen sponge intended to serve as a substitute for autogenous connective tissue grafts (CTGs), a dynamic bioreactor system was developed. Pressure and shear forces can be applied in this bioreactor in addition to a constant medium perfusion to cell-material constructs. Three-dimensional volume changes and stiffness of the matrices were analyzed. In addition, cell responses such as cell vitality and extracellular matrix (ECM) production were investigated. The number of metabolic active cells constantly increased under fully dynamic culture conditions. The sponges remained elastic even after mechanical forces were applied for 14 days. Analysis of collagen type I and fibronectin revealed a statistically significant accumulation of these ECM molecules (P < 0.05-0.001) when compared to static cultures. An increased expression of tenascin-c, indicating tissue remodeling processes, was observed under dynamic conditions only. The results indicate that the tested in vitro cell culture system was able to mimic both the biological and mechanical environments of the clinical situation in a healing wound. © 2010 Wiley Periodicals, Inc.

Human influence on Canadian temperatures

NASA Astrophysics Data System (ADS)

Wan, Hui; Zhang, Xuebin; Zwiers, Francis

2018-02-01

Canada has experienced some of the most rapid warming on Earth over the past few decades with a warming rate about twice that of the global mean temperature since 1948. Long-term warming is observed in Canada's annual, winter and summer mean temperatures, and in the annual coldest and hottest daytime and nighttime temperatures. The causes of these changes are assessed by comparing observed changes with climate model simulated responses to anthropogenic and natural (solar and volcanic) external forcings. Most of the observed warming of 1.7 °C increase in annual mean temperature during 1948-2012 [90% confidence interval (1.1°, 2.2 °C)] can only be explained by external forcing on the climate system, with anthropogenic influence being the dominant factor. It is estimated that anthropogenic forcing has contributed 1.0 °C (0.6°, 1.5 °C) and natural external forcing has contributed 0.2 °C (0.1°, 0.3 °C) to the observed warming. Up to 0.5 °C of the observed warming trend may be associated with low frequency variability of the climate such as that represented by the Pacific decadal oscillation (PDO) and North Atlantic oscillation (NAO). Overall, the influence of both anthropogenic and natural external forcing is clearly evident in Canada-wide mean and extreme temperatures, and can also be detected regionally over much of the country.

Stability diagram for the forced Kuramoto model.

PubMed

Childs, Lauren M; Strogatz, Steven H

2008-12-01

We analyze the periodically forced Kuramoto model. This system consists of an infinite population of phase oscillators with random intrinsic frequencies, global sinusoidal coupling, and external sinusoidal forcing. It represents an idealization of many phenomena in physics, chemistry, and biology in which mutual synchronization competes with forced synchronization. In other words, the oscillators in the population try to synchronize with one another while also trying to lock onto an external drive. Previous work on the forced Kuramoto model uncovered two main types of attractors, called forced entrainment and mutual entrainment, but the details of the bifurcations between them were unclear. Here we present a complete bifurcation analysis of the model for a special case in which the infinite-dimensional dynamics collapse to a two-dimensional system. Exact results are obtained for the locations of Hopf, saddle-node, and Takens-Bogdanov bifurcations. The resulting stability diagram bears a striking resemblance to that for the weakly nonlinear forced van der Pol oscillator.

Safety evaluation of large external fixation clamps and frames in a magnetic resonance environment.

PubMed

Luechinger, Roger; Boesiger, Peter; Disegi, John A

2007-07-01

Large orthopedic external fixation clamps and related components were evaluated for force, torque, and heating response when subjected to the strong electromagnetic fields of magnetic-resonance (MR) imaging devices. Forces induced by a 3-Tesla (T) MR scanner were compiled for newly designed nonmagnetic clamps and older clamps that contained ferromagnetic components. Heating trials were performed in a 1.5 and in a 3 T MR scanner with two assembled external fixation frames. Forces of the newly designed clamps were more than a factor 2 lower as the gravitational force on the device whereas, magnetic forces on the older devices showed over 10 times the force induced by earth acceleration of gravity. No torque effects could be found for the newly designed clamps. Temperature measurements at the tips of Schanz screws in the 1.5 T MR scanner showed a rise of 0.7 degrees C for a pelvic frame and of 2.1 degrees C for a diamond knee bridge frame when normalized to a specific absorption rate (SAR) of 2 W/kg. The normalized temperature increases in the 3 T MR scanner were 0.9 degrees C for the pelvic frame and 1.1 degrees C for the knee bridge frame. Large external fixation frames assembled with the newly designed clamps (390 Series Clamps), carbon fiber reinforced rods, and implant quality 316L stainless steel Schanz screws met prevailing force and torque limits when tested in a 3-T field, and demonstrated temperature increase that met IEC-60601 guidelines for extremities. The influence of frame-induced eddy currents on the risk of peripheral nerve stimulation was not investigated. Copyright 2006 Wiley Periodicals, Inc.

Effect of depth on shear-wave elastography estimated in the internal and external cervical os during pregnancy

PubMed Central

Hernandez-Andrade, Edgar; Aurioles-Garibay, Alma; Garcia, Maynor; Korzeniewski, Steven J.; Schwartz, Alyse G.; Ahn, Hyunyoung; Martinez-Varea, Alicia; Yeo, Lami; Chaiworapongsa, Tinnakorn; Hassan, Sonia S.; Romero, Roberto

2014-01-01

Aim To investigate the effect of depth on cervical shear-wave elastography. Methods Shear-wave elastography was applied to estimate the velocity of propagation of the acoustic force impulse (shear-wave) in the cervix of 154 pregnant women at 11-36 weeks of gestation. Shear-wave speed (SWS) was evaluated in cross-sectional views of the internal and external cervical os in five regions of interest: anterior, posterior, lateral right, lateral left, and endocervix. Distance from the center of the US transducer to the center of the each region of interest was registered. Results In all regions, SWS decreased significantly with gestational age (p=0.006). In the internal os SWS was similar among the anterior, posterior and lateral regions, and lower in the endocervix. In the external os, the endocervix and anterior regions showed similar SWS values, lower than those from the posterior and lateral regions. In the endocervix, these differences remained significant after adjustment for depth, gestational age and cervical length. SWS estimations in all regions of the internal os were higher than those of the external os, suggesting denser tissue. Conclusion Depth from the ultrasound probe to different regions in the cervix did not significantly affect the SWS estimations. PMID:25029081

Electric Field Induced Interfacial Instabilities

NASA Technical Reports Server (NTRS)

Kusner, Robert E.; Min, Kyung Yang; Wu, Xiao-Lun; Onuki, Akira

1996-01-01

The study of the interface in a charge-free, nonpolar, critical and near-critical binary fluid in the presence of an externally applied electric field is presented. At sufficiently large fields, the interface between the two phases of the binary fluid should become unstable and exhibit an undulation with a predefined wavelength on the order of the capillary length. As the critical point is approached, this wavelength is reduced, potentially approaching length-scales such as the correlation length or critical nucleation radius. At this point the critical properties of the system may be affected. In zero gravity, the interface is unstable at all long wavelengths in the presence of a field applied across it. It is conjectured that this will cause the binary fluid to break up into domains small enough to be outside the instability condition. The resulting pattern formation, and the effects on the critical properties as the domains approach the correlation length are of acute interest. With direct observation, laser light scattering, and interferometry, the phenomena can be probed to gain further understanding of interfacial instabilities and the pattern formation which results, and dimensional crossover in critical systems as the critical fluctuations in a particular direction are suppressed by external forces.

Evolution of a phase separated gravity independent bioreactor

NASA Technical Reports Server (NTRS)

Villeneuve, Peter E.; Dunlop, Eric H.

1992-01-01

The evolution of a phase-separated gravity-independent bioreactor is described. The initial prototype, a zero head-space manifold silicone membrane based reactor, maintained large diffusional resistances. Obtaining oxygen transfer rates needed to support carbon-recycling aerobic microbes is impossible if large resistances are maintained. Next generation designs (Mark I and II) mimic heat exchanger design to promote turbulence at the tubing-liquid interface, thereby reducing liquid and gas side diffusional resistances. While oxygen transfer rates increased by a factor of ten, liquid channeling prevented further increases. To overcome these problems, a Mark III reactor was developed which maintains inverted phases, i.e., media flows inside the silicone tubing, oxygen gas is applied external to the tubing. This enhances design through changes in gas side driving force concentration and liquid side turbulence levels. Combining an applied external pressure of 4 atm with increased Reynolds numbers resulted in oxygen transfer intensities of 232 mmol O2/l per hr (1000 times greater than the first prototype and comparable to a conventional fermenter). A 1.0 liter Mark III reactor can potentially deliver oxygen supplies necessary to support cell cultures needed to recycle a 10-astronaut carbon load continuously.

Rapid communication: Computational simulation and analysis of a candidate for the design of a novel silk-based biopolymer.

PubMed

Golas, Ewa I; Czaplewski, Cezary

2014-09-01

This work theoretically investigates the mechanical properties of a novel silk-derived biopolymer as polymerized in silico from sericin and elastin-like monomers. Molecular Dynamics simulations and Steered Molecular Dynamics were the principal computational methods used, the latter of which applies an external force onto the system and thereby enables an observation of its response to stress. The models explored herein are single-molecule approximations, and primarily serve as tools in a rational design process for the preliminary assessment of properties in a new material candidate. © 2014 Wiley Periodicals, Inc.

Nonlinear generation of sum and difference frequency waves by two helicon waves in a semiconductor

NASA Astrophysics Data System (ADS)

Salimullah, M.; Ferdous, T.

1984-05-01

This paper presents a theoretical investigation of the nonlinear generation of electrostatic waves at the sum and the difference frequency when two high amplitude elliptically polarized helicon waves propagate along the direction of the externally applied static magnetic field in an n-type semiconductor. The nonlinearity arises through the ponderomotive force on electrons. It is noticed that the power conversion efficiency of the difference frequency generation is much larger than that of the sum frequency generation. The power conversion efficiency may be easily increased by increasing the density of electrons in the semiconductor.

Efficiency of autonomous soft nanomachines at maximum power.

PubMed

Seifert, Udo

2011-01-14

We consider nanosized artificial or biological machines working in steady state enforced by imposing nonequilibrium concentrations of solutes or by applying external forces, torques, or electric fields. For unicyclic and strongly coupled multicyclic machines, efficiency at maximum power is not bounded by the linear response value 1/2. For strong driving, it can even approach the thermodynamic limit 1. Quite generally, such machines fall into three different classes characterized, respectively, as "strong and efficient," "strong and inefficient," and "balanced." For weakly coupled multicyclic machines, efficiency at maximum power has lost any universality even in the linear response regime.

Corona anemometry for qualitative measurement of reversing surface flow with application to separation control by external excitation

NASA Technical Reports Server (NTRS)

Durbin, P. A.; Mckinzie, D. J.

1987-01-01

An corona anemometer which detects gas flow by the displacement of an ion beam is described, and experiments are performed using the anemometer to investigate the active control of diffusor separation by periodic forcing. The apparatus is applied to the separated flow over a rearward facing ramp. An oscillating vane is attached to the surface near the separation point. It is suggested that the enhancement in turbulent energy produced by the oscillating vane is due to drastic modification of the wake shear flow, and not to vane-produced turbulence.

Optical lithography of three-dimensional magnetophotonic microdevices

NASA Astrophysics Data System (ADS)

Nguyen, Dam Thuy Trang; Del Guercio, Olivia; Au, Thi Huong; Trinh, Duc Thien; Mai, Nguyen Phuong Thao; Lai, Ngoc Diep

2018-04-01

We have recently demonstrated a simple and low-cost fabrication technique, called low one-photon absorption direct laser writing, to realize desired polymeric microstructures. We present the use of this technique for fabrication of three-dimensional magnetophotonic devices on a photocurable homogeneous nanocomposite consisting of magnetite (Fe3O4) nanoparticles and a commercial SU8 photoresist. The fabricated magnetophotonic microstructures show strong response to an applied external magnetic field. Thus, various three-dimensional submicromechanical magnetophotonic devices, which can be mechanically driven by magnetic force, are designed and created. Potential applications of these devices are also discussed.

Vibro-Impact Type Triboelectric Energy Harvester for Large Amplitude and Wideband Applications

NASA Astrophysics Data System (ADS)

Chen, J. M.; Bu, L.; Xu, W. Y.; Xu, B. J.; Song, L.

2015-12-01

This paper reports the design, fabrication and testing of a novel vibro-impact type triboelectric energy harvester. The dynamics of vibro-impact converts external vibration to large contact force for triboelectric power generation. Strong nonlinearities are measured for this vibro-impact system, and wideband frequency response under diverse structural parameters are analyzed. The proposed device is applied in two large amplitude scenarios, and generates maximal peak-to-peak voltage of 18V in foot swinging condition @2Hz 30cm, and maximal peak-to-peak voltage of 45 V in arm swinging condition during running @5Hz 40cm.

Correlates of Romantic Love

ERIC Educational Resources Information Center

Dion, Kenneth L.; Dion, Karen K.

1973-01-01

Relationships between internal-external control and romantic love were hypothesized on the basis of a social influence interpretation and the view that romantic love is culturally stereotyped as an external force. Consistent with these perspectives, proportionally fewer internals than externals reported having been romantically attached. (Author)

Blades Forced Vibration Under Aero-Elastic Excitation Modeled by Van der Pol

NASA Astrophysics Data System (ADS)

Pust, Ladislav; Pesek, Ludek

This paper employs a new analytical approach to model the influence of aerodynamic excitation on the dynamics of a bladed cascade at the flutter state. The flutter is an aero-elastic phenomenon that is linked to the interaction of the flow and the traveling deformation wave in the cascade when only the damping of the cascade changes. As a case study the dynamic properties of the five-blade-bunch excited by the running harmonic external forces and aerodynamic self-excited forces are investigated. This blade-bunch is linked in the shroud by means of the viscous-elastic damping elements. The external running excitation depends on the ratio of stator and rotor blade numbers and corresponds to the real type of excitation in the steam turbine. The aerodynamic self-excited forces are modeled by two types of Van der Pol nonlinear models. The influence of the interaction of both types of self-excitation with the external running excitation is investigated on the response curves.

Static Prehension of a Horizontally Oriented Object in Three Dimensions

PubMed Central

Wu, Yen-Hsun; Zatsiorsky, Vladimir M.; Latash, Mark L.

2011-01-01

We studied static prehension of a horizontally oriented object. Specific hypotheses were explored addressing such issues as the sharing patterns of the total moment of force across the digits, presence of mechanically unnecessary digit forces, and trade-off between multi-digit synergies at the two levels of the assumed control hierarchy. Within the assumed hierarchy, at the upper level, the task is shared between the thumb and virtual finger (an imagined finger producing a wrench equal to the sum of the wrenches of individual fingers). At the lower level, action of the virtual finger is shared among the four actual fingers. The subjects held statically a horizontally oriented handle instrumented with six-component force/torque sensors with different loads and torques acting about the long axis of the handle. The thumb acted from above while the four fingers supported the weight of the object. When the external torque was zero, the thumb produced mechanically unnecessary force of about 2.8 N, which did not depend on the external load magnitude. When the external torque was not zero, tangential forces produced over 80% of the total moment of force. The normal forces by the middle and ring fingers produced consistent moments against the external torque, while the normal forces of the index and little fingers did not. Force and moment variables at both hierarchical levels were stabilized by co-varied across trials adjustments of forces/moments produced by individual digits with the exception of the normal force analyzed at the lower level of the hierarchy. There was a trade-off between synergy indices computed at the two levels of the hierarchy for the three components of the total force vector, but not for the moment of force components. Overall, the results have shown that task mechanics are only one factor that defines forces produced by individual digits. Other factors, such as loading sensory receptors may lead to mechanically unnecessary forces. There seems to be no single rule (for example, ensuring similar safety margin values) that would describe sharing of the normal and tangential forces and be valid across tasks. Fingers that are traditionally viewed as less accurate (e.g., the ring finger) may perform more consistently in certain tasks. The observations of the trade-off between the synergy indices computed at two levels for the force variables but not for the moment of force variables suggest that the degree of redundancy (the number of excessive elemental variables) at the higher level is an important factor. PMID:22071684

On structural transitions, thermodynamic equilibrium, and the phase diagram of DNA and RNA duplexes under torque and tension.

PubMed

Wereszczynski, Jeff; Andricioaei, Ioan

2006-10-31

A precise understanding of the flexibility of double stranded nucleic acids and the nature of their deformed conformations induced by external forces is important for a wide range of biological processes including transcriptional regulation, supercoil and catenane removal, and site-specific recombination. We present, at atomic resolution, a simulation of the dynamics involved in the transitions from B-DNA and A-RNA to Pauling (P) forms and to denatured states driven by application of external torque and tension. We then calculate the free energy profile along a B- to P-transition coordinate and from it, compute a reversible pathway, i.e., an isotherm of tension and torque pairs required to maintain P-DNA in equilibrium. The reversible isotherm maps correctly onto a phase diagram derived from single molecule experiments, and yields values of elongation, twist, and twist-stretch coupling in agreement with measured values. We also show that configurational entropy compensates significantly for the large electrostatic energy increase due to closer-packed P backbones. A similar set of simulations applied to RNA are used to predict a novel structure, P-RNA, with its associated free energy, equilibrium tension, torque and structural parameters, and to assign the location, on the phase-diagram, of a putative force-torque-dependent RNA "triple point."

A simple method for assessment of muscle force, velocity, and power producing capacities from functional movement tasks.

PubMed

Zivkovic, Milena Z; Djuric, Sasa; Cuk, Ivan; Suzovic, Dejan; Jaric, Slobodan

2017-07-01

A range of force (F) and velocity (V) data obtained from functional movement tasks (e.g., running, jumping, throwing, lifting, cycling) performed under variety of external loads have typically revealed strong and approximately linear F-V relationships. The regression model parameters reveal the maximum F (F-intercept), V (V-intercept), and power (P) producing capacities of the tested muscles. The aim of the present study was to evaluate the level of agreement between the routinely used "multiple-load model" and a simple "two-load model" based on direct assessment of the F-V relationship from only 2 external loads applied. Twelve participants were tested on the maximum performance vertical jumps, cycling, bench press throws, and bench pull performed against a variety of different loads. All 4 tested tasks revealed both exceptionally strong relationships between the parameters of the 2 models (median R = 0.98) and a lack of meaningful differences between their magnitudes (fixed bias below 3.4%). Therefore, addition of another load to the standard tests of various functional tasks typically conducted under a single set of mechanical conditions could allow for the assessment of the muscle mechanical properties such as the muscle F, V, and P producing capacities.

Kinematic evaluation of patients with total and reverse shoulder arthroplasty during rehabilitation exercises with different loads.

PubMed

de Toledo, Joelly Mahnic; Loss, Jefferson Fagundes; Janssen, Thomas W; van der Scheer, Jan W; Alta, Tjarco D; Willems, W Jaap; Veeger, DirkJan H E J

2012-10-01

Following shoulder arthroplasty, any well-planned rehabilitation program should include muscle strengthening. However, it is not always clear how different external loads influence shoulder kinematics in patients with shoulder prostheses. The objective of this study was to describe shoulder kinematics and determine the contribution of the scapulothoracic joint to total shoulder motion of patients with total and reverse shoulder arthroplasties and of healthy individuals during rehabilitation exercises (anteflexion and elevation in the scapular plane) using different loading conditions (without external load, 1 kg and elastic resistance). Shoulder motions were measured using an electromagnetic tracking device. A force transducer was used to record force signals during loaded conditions using elastic resistance. Statistical comparisons were made using a three-way repeated-measures analysis of variance with a Bonferroni post hoc testing. The scapula contributed more to movement of the arm in subjects with prostheses compared to healthy subjects. The same applies for loaded conditions (1 kg and elastic resistance) relative to unloaded tasks. For scapular internal rotation, upward rotation and posterior tilt no significant differences among groups were found during both exercises. Glenohumeral elevation angles during anteflexion were significantly higher in the total shoulder arthroplasty group compared to the reverse shoulder arthroplasty group. Differences in contribution of the scapula to total shoulder motion between patients with different types of arthroplasties were not significant. However, compared to healthy subjects, they were. Furthermore, scapular kinematics of patients with shoulder arthroplasty was influenced by implementation of external loads, but not by the type of load. Copyright © 2012 Elsevier Ltd. All rights reserved.

Two-loads Method for Distinguishing among the Muscle Force, Velocity, and Power Producing Capacities

PubMed Central

Jaric, Slobodan

2016-01-01

It has been generally accepted that muscles could have different mechanical capacities, such as those for producing high force (F), velocity (V), and power (P) outputs. Nevertheless, the standard procedures of the evaluation of muscle function both in research and routine testing are typically conducted under a single mechanical condition, such as under a single external load. Therefore, the observed outcomes do not allow for distinguishing among the different muscle capacities. As a result, the outcomes of most of the routine testing procedures have been of limited informational value, while a number of debated issues in research have originated from arbitrarily interpreted experimental findings regarding specific muscle capacities. A solution for the discussed problem could be based on the approximately linear and exceptionally strong F-V relationship typically observed from various functional tasks performed under different external loads. These findings allow for the 'two-loads method' proposed in this Current Opinion: the functional movement tasks (e.g., maximum jumping, cycling, running, pushing, lifting, or throwing) should be tested against just 2 distinctive external loads. Namely, the F-V relationship determined by 2 pairs of the F and V data could provide the parameters depicting the maximum F (i.e., the F-intercept), V (V-intercept), and P (calculated from the product of F and V) output of the tested muscles. Therefore, the proposed two-loads method applied in both research and routine testing could provide a deeper insight into the mechanical properties and function of the tested muscles and resolve a number of debated issues in the literature. PMID:27075326

The effect of the arthroscopic augmentation of the subscapularis tendon on shoulder instability and range of motion: A biomechanical study.

PubMed

Schröter, S; Krämer, M; Welke, B; Hurschler, C; Russo, R; Herbst, M; Stöckle, U; Ateschrang, A; Maiotti, M

2016-10-01

Anterior shoulder dislocation is common. The treatment of recurrence with glenoid bone defect is still considered controversial. A new arthroscopic subscapularis augmentation has recently been described that functions to decrease the anterior translation of the humeral head. The purpose of the presented study was to examine the biomechanical effect on glenohumeral joint motion and stability. Eight fresh frozen cadaver shoulders were studied by use of a force guided industrial robot fitted with a six-component force-moment sensor to which the humerus was attached. The testing protocol includes measurement of glenohumeral translation in the anterior, anterior-inferior and inferior directions at 0°, 30° and 60° of glenohumeral abduction, respectively, with a passive humerus load of 30N in the testing direction. The maximum possible external rotation was measured at each abduction angle applying a moment of 1Nm. Each specimen was measured in a physiologic state, as well as after Bankart lesion with an anterior bone defect of 15-20% of the glenoid, after arthroscopic subscapularis augmentation and after Bankart repair. The arthroscopic subscapularis augmentation decreased the anterior and anterior-inferior translation. The Bankart repair did not restore the mechanical stability compared to the physiologic shoulder group. External rotation was decreased after arthroscopic subscapularis augmentation compared to the physiologic state, however, the limitation of external rotation was decreased at 60° abduction. The arthroscopic subscapularis augmentation investigated herein was observed to restore shoulder stability in an experimental model. Copyright © 2016 Elsevier Ltd. All rights reserved.

Nonstationary time series prediction combined with slow feature analysis

NASA Astrophysics Data System (ADS)

Wang, G.; Chen, X.

2015-07-01

Almost all climate time series have some degree of nonstationarity due to external driving forces perturbing the observed system. Therefore, these external driving forces should be taken into account when constructing the climate dynamics. This paper presents a new technique of obtaining the driving forces of a time series from the slow feature analysis (SFA) approach, and then introduces them into a predictive model to predict nonstationary time series. The basic theory of the technique is to consider the driving forces as state variables and to incorporate them into the predictive model. Experiments using a modified logistic time series and winter ozone data in Arosa, Switzerland, were conducted to test the model. The results showed improved prediction skills.

Advances in Quantum Mechanochemistry: Electronic Structure Methods and Force Analysis.

PubMed

Stauch, Tim; Dreuw, Andreas

2016-11-23

In quantum mechanochemistry, quantum chemical methods are used to describe molecules under the influence of an external force. The calculation of geometries, energies, transition states, reaction rates, and spectroscopic properties of molecules on the force-modified potential energy surfaces is the key to gain an in-depth understanding of mechanochemical processes at the molecular level. In this review, we present recent advances in the field of quantum mechanochemistry and introduce the quantum chemical methods used to calculate the properties of molecules under an external force. We place special emphasis on quantum chemical force analysis tools, which can be used to identify the mechanochemically relevant degrees of freedom in a deformed molecule, and spotlight selected applications of quantum mechanochemical methods to point out their synergistic relationship with experiments.

Every Mass or Mass Group When Created Will have No Motion, Linear, Rotational or Vibratory Motion, Singly or in Some Combination, Which May Be Later Modified by External Forces--A Natural Law

NASA Astrophysics Data System (ADS)

Brekke, Stewart

2010-03-01

Every mass or mass group, from atoms and molecules to stars and galaxies,has no motion, is vibrating, rotating,or moving linearly, singularly or in some combination. When created, the excess energy of creation will generate a vibration, rotation and/or linear motion besides the mass or mass group. Curvilinear or orbital motion is linear motion in an external force field. External forces, such as photon, molecular or stellar collisions may over time modify the inital rotational, vibratory or linear motions of the mass of mass group. The energy equation for each mass or mass group is E=mc^2 + 1/2mv^2 + 1/2I2̂+ 1/2kx0^2 + WG+ WE+ WM.

Response to a small external force and fluctuations of a passive particle in a one-dimensional diffusive environment

NASA Astrophysics Data System (ADS)

Huveneers, François

2018-04-01

We investigate the long-time behavior of a passive particle evolving in a one-dimensional diffusive random environment, with diffusion constant D . We consider two cases: (a) The particle is pulled forward by a small external constant force and (b) there is no systematic bias. Theoretical arguments and numerical simulations provide evidence that the particle is eventually trapped by the environment. This is diagnosed in two ways: The asymptotic speed of the particle scales quadratically with the external force as it goes to zero, and the fluctuations scale diffusively in the unbiased environment, up to possible logarithmic corrections in both cases. Moreover, in the large D limit (homogenized regime), we find an important transient region giving rise to other, finite-size scalings, and we describe the crossover to the true asymptotic behavior.

Unbinding Transition of Probes in Single-File Systems

NASA Astrophysics Data System (ADS)

Bénichou, Olivier; Démery, Vincent; Poncet, Alexis

2018-02-01

Single-file transport, arising in quasi-one-dimensional geometries where particles cannot pass each other, is characterized by the anomalous dynamics of a probe, notably its response to an external force. In these systems, the motion of several probes submitted to different external forces, although relevant to mixtures of charged and neutral or active and passive objects, remains unexplored. Here, we determine how several probes respond to external forces. We rely on a hydrodynamic description of the symmetric exclusion process to obtain exact analytical results at long times. We show that the probes can either move as a whole, or separate into two groups moving away from each other. In between the two regimes, they separate with a different dynamical exponent, as t1 /4. This unbinding transition also occurs in several continuous single-file systems and is expected to be observable.

Internal phase transition induced by external forces in Finsler geometric model for membranes

NASA Astrophysics Data System (ADS)

Koibuchi, Hiroshi; Shobukhov, Andrey

2016-10-01

In this paper, we numerically study an anisotropic shape transformation of membranes under external forces for two-dimensional triangulated surfaces on the basis of Finsler geometry. The Finsler metric is defined by using a vector field, which is the tangential component of a three-dimensional unit vector σ corresponding to the tilt or some external macromolecules on the surface of disk topology. The sigma model Hamiltonian is assumed for the tangential component of σ with the interaction coefficient λ. For large (small) λ, the surface becomes oblong (collapsed) at relatively small bending rigidity. For the intermediate λ, the surface becomes planar. Conversely, fixing the surface with the boundary of area A or with the two-point boundaries of distance L, we find that the variable σ changes from random to aligned state with increasing of A or L for the intermediate region of λ. This implies that an internal phase transition for σ is triggered not only by the thermal fluctuations, but also by external mechanical forces. We also find that the frame (string) tension shows the expected scaling behavior with respect to A/N (L/N) at the intermediate region of A (L) where the σ configuration changes between the disordered and ordered phases. Moreover, we find that the string tension γ at sufficiently large λ is considerably smaller than that at small λ. This phenomenon resembles the so-called soft-elasticity in the liquid crystal elastomer, which is deformed by small external tensile forces.

Towards Subject-Specific Strength Training Design through Predictive Use of Musculoskeletal Models.

PubMed

Plüss, Michael; Schellenberg, Florian; Taylor, William R; Lorenzetti, Silvio

2018-01-01

Lower extremity dysfunction is often associated with hip muscle strength deficiencies. Detailed knowledge of the muscle forces generated in the hip under specific external loading conditions enables specific structures to be trained. The aim of this study was to find the most effective movement type and loading direction to enable the training of specific parts of the hip muscles using a standing posture and a pulley system. In a novel approach to release the predictive power of musculoskeletal modelling techniques based on inverse dynamics, flexion/extension and ab-/adduction movements were virtually created. To demonstrate the effectiveness of this approach, three hip orientations and an external loading force that was systematically rotated around the body were simulated using a state-of-the art OpenSim model in order to establish ideal designs for training of the anterior and posterior parts of the M. gluteus medius (GM). The external force direction as well as the hip orientation greatly influenced the muscle forces in the different parts of the GM. No setting was found for simultaneous training of the anterior and posterior parts with a muscle force higher than 50% of the maximum. Importantly, this study has demonstrated the use of musculoskeletal models as an approach to predict muscle force variations for different strength and rehabilitation exercise variations.

Towards Subject-Specific Strength Training Design through Predictive Use of Musculoskeletal Models

PubMed Central

Plüss, Michael; Schellenberg, Florian

2018-01-01

Lower extremity dysfunction is often associated with hip muscle strength deficiencies. Detailed knowledge of the muscle forces generated in the hip under specific external loading conditions enables specific structures to be trained. The aim of this study was to find the most effective movement type and loading direction to enable the training of specific parts of the hip muscles using a standing posture and a pulley system. In a novel approach to release the predictive power of musculoskeletal modelling techniques based on inverse dynamics, flexion/extension and ab-/adduction movements were virtually created. To demonstrate the effectiveness of this approach, three hip orientations and an external loading force that was systematically rotated around the body were simulated using a state-of-the art OpenSim model in order to establish ideal designs for training of the anterior and posterior parts of the M. gluteus medius (GM). The external force direction as well as the hip orientation greatly influenced the muscle forces in the different parts of the GM. No setting was found for simultaneous training of the anterior and posterior parts with a muscle force higher than 50% of the maximum. Importantly, this study has demonstrated the use of musculoskeletal models as an approach to predict muscle force variations for different strength and rehabilitation exercise variations. PMID:29796082

Hydrodynamic interactions induce movement against an external load in a ratchet dimer Brownian motor.

PubMed

Fornés, José A

2010-01-15

We use the Brownian dynamics with hydrodynamic interactions simulation in order to describe the movement of a elastically coupled dimer Brownian motor in a ratchet potential. The only external forces considered in our system were the load, the random thermal noise and an unbiased thermal fluctuation. For a given set of parameters we observe direct movement against the load force if hydrodynamic interactions were considered.

Reduction of Effective Acceleration to Microgravity Levels

NASA Technical Reports Server (NTRS)

Downey, James P.

2000-01-01

Acceleration due to earth's gravity causes buoyancy driven convection and sedimentation in solutions. In addition. pressure gradients occur as a function of the height within a liquid column. Hence gravity effects both equilbria conditions and phase transitions as a result of hydrostatic pressure gradients. The affect of gravity on the rate of heat and man transfer in solutal processes can be particularly important in polymer processing due to the high sensitivity of polymeric materials to processing conditions. The term microgravity has been coined to describe an environment in which the affects of gravitational acceleration am greatly reduced. It may seem odd to talk in term of reducing the effects of gravitational acceleration since gravitational attraction is a basic property of matter. However, die presence of gravity on in situ processing or measurements can be negated by achieving conditions in which the laboratory, or more specifically the container of the experimental materials, a subjected to the same acceleration as the materials themselves. With regard to the laboratory reference frame, there is virtually no force on the experimental solutions. This is difficult to achieve but can be done. A short review of Newtonian physics provides an explanation on both how processes we affected by gravity and how microgravity conditions are achieved. The fact that fluids deform when subject to a force bid solids do not indicates that solids have a structure able to exert an opposing force that negates an externally applied force. Liquids deform when a force is applied, indicating that a liquid structure cannot completely negate an applied force. Just how easily a liquid resists deformation is related to its viscosity. Spaceflight provides an environment in which the laboratory reference frame i.e. the spacecraft and all the equipment therein an experiencing virtually identical forces. There is no solid foundation underneath such a laboratory, so the laboratory accelerates according to the force of gravity as do the experimental fluids within the lab. Hence, the magnitude of the form excited by the laboratory on the experimental solutions within are greatly reduced. When compared with a laboratory on the ground and averaged over time, the fluids in a spaceflight laboratory experience approximately a 10 (sup -6)decrease in acceleration relative to their laboratory reference frame hence the term microgravity.

Effect of flow oscillations on cavity drag and a technique for their control

NASA Technical Reports Server (NTRS)

Gharib, M.; Roshko, A.; Sarohia, V.

1985-01-01

Experiments to relate the state of the shear layer to cavity drag have been performed in a water channel using a 4" axisymmetric cavity model. Detailed flow measurements in various cavity flow oscillation phases, amplitude amplification along the flow direction, distribution of shear stress, and other momentum flux obtained by laser Doppler velocimeter are presented. Measurements show exponential dependence of cavity drag on the length of the cavity. A jump in the cavity drag coefficient is observed as the cavity flow shows a bluff body wake type behavior. Natural and forced oscillations are introduced by a sinusoidally heated thin-film strip which excites the Tollmein-Schlichting waves in the boundary layer upstream of the gap. For a large gap, self-sustained periodic oscillations are observed, while for smaller gaps, which do not oscillate naturally, periodical oscillations can be obtained by external forcing through the strip heater. The drag of the cavity can be increased by one order of magnitude in the non-oscillating case through external forcing. Also, it is possible to completely eliminate mode switching by external forcing. For the first time, it is demonstrated that amplitude of cavity flow Kelvin-Helmholtz wave is dampened or cancelled by introduction of external perturbation of natural flow frequency but different phase.

Permeability of continental crust influenced by internal and external forcing

USGS Publications Warehouse

Rojstaczer, S.A.; Ingebritsen, S.E.; Hayba, D.O.

2008-01-01

The permeability of continental crust is so highly variable that it is often considered to defy systematic characterization. However, despite this variability, some order has been gleaned from globally compiled data. What accounts for the apparent coherence of mean permeability in the continental crust (and permeability-depth relations) on a very large scale? Here we argue that large-scale crustal permeability adjusts to accommodate rates of internal and external forcing. In the deeper crust, internal forcing - fluxes induced by metamorphism, magmatism, and mantle degassing - is dominant, whereas in the shallow crust, external forcing - the vigor of the hydrologic cycle - is a primary control. Crustal petrologists have long recognized the likelihood of a causal relation between fluid flux and permeability in the deep, ductile crust, where fluid pressures are typically near-lithostatic. It is less obvious that such a relation should pertain in the relatively cool, brittle upper crust, where near-hydrostatic fluid pressures are the norm. We use first-order calculations and numerical modeling to explore the hypothesis that upper-crustal permeability is influenced by the magnitude of external fluid sources, much as lower-crustal permeability is influenced by the magnitude of internal fluid sources. We compare model-generated permeability structures with various observations of crustal permeability. ?? 2008 The Authors Journal compilation ?? 2008 Blackwell Publishing Ltd.

Volumetric flow rate in simulations of microfluidic devices+

NASA Astrophysics Data System (ADS)

Kovalčíková, KristÍna; Slavík, Martin; Bachratá, Katarína; Bachratý, Hynek; Bohiniková, Alžbeta

2018-06-01

In this work, we examine the volumetric flow rate of microfluidic devices. The volumetric flow rate is a parameter which is necessary to correctly set up a simulation of a real device and to check the conformity of a simulation and a laboratory experiments [1]. Instead of defining the volumetric rate at the beginning as a simulation parameter, a parameter of external force is set. The proposed hypothesis is that for a fixed set of other parameters (topology, viscosity of the liquid, …) the volumetric flow rate is linearly dependent on external force in typical ranges of fluid velocity used in our simulations. To confirm this linearity hypothesis and to find numerical limits of this approach, we test several values of the external force parameter. The tests are designed for three different topologies of simulation box and for various haematocrits. The topologies of the microfluidic devices are inspired by existing laboratory experiments [3 - 6]. The linear relationship between the external force and the volumetric flow rate is verified in orders of magnitudes similar to the values obtained from laboratory experiments. Supported by the Slovak Research and Development Agency under the contract No. APVV-15-0751 and by the Ministry of Education, Science, Research and Sport of the Slovak Republic under the contract No. VEGA 1/0643/17.

Verified solutions for the gravitational attraction to an oblate spheroid: Implications for planet mass and satellite orbits

NASA Astrophysics Data System (ADS)

Hofmeister, Anne M.; Criss, Robert E.; Criss, Everett M.

2018-03-01

Forces external to the oblate spheroid shape, observed from planetary to galactic scales, are demonstrably non-central, which has important ramifications for planetary science. We simplify historic formulae and derive new analytical solutions for the gravitational potential and force outside a constant density oblate. Numerical calculations that sum point mass contributions in a >109 element mesh confirm our equations. We show that contours of constant force and potential about oblate bodies are closely approximated by two confocal families whose foci (f) respectively are (9/10)½ae and (3/5)½ae for a body with f = ae. This leads to useful approximations that address internal density variations. We demonstrate that the force on a general point is not directed towards the oblate's center, nor are forces simply proportional to the inverse square of that distance, despite forces in the equatorial and axial directions pointing towards the center. Our results explain complex dynamics of galactic systems. Because most planets and stars have an aspect ratio >0.9, the spherical approximation is reasonable except for orbits within ∼2 body radii. We show that applying the "generalized" potential, which assumes central forces, yields J2 values half those expected for oblate bodies, and probably underestimates masses of Uranus and Neptune by ∼0.2%. We show that the inner Saturnian moons are subject to non-central forces, which may affect calculations of their orbital precession. Our new series should improve interpretation of flyby data.

Dissipative, forced turbulence in two-dimensional magnetohydrodynamics

NASA Technical Reports Server (NTRS)

Fyfe, D.; Montgomery, D.; Joyce, G.

1976-01-01

The equations of motion for turbulent two-dimensional magnetohydrodynamic flows are solved in the presence of finite viscosity and resistivity, for the case in which external forces (mechanical and/or magnetic) act on the fluid. The goal is to verify the existence of a magnetohydrodynamic dynamo effect which is represented mathematically by a substantial back-transfer of mean square vector potential to the longest allowed Fourier wavelengths. External forces consisting of a random part plus a fraction of the value at the previous time step are employed, after the manner of Lilly for the Navier-Stokes case. The regime explored is that for which the mechanical and magnetic Reynolds numbers are in the region of 100 to 1000. The conclusions are that mechanical forcing terms alone cannot lead to dynamo action, but that dynamo action can result from either magnetic forcing terms or from both mechanical and magnetic forcing terms simultaneously.

Joint moments and contact forces in the foot during walking.

PubMed

Kim, Yongcheol; Lee, Kyoung Min; Koo, Seungbum

2018-06-06

The net force and moment of a joint have been widely used to understand joint disease in the foot. Meanwhile, it does not reflect the physiological forces on muscles and contact surfaces. The objective of the study is to estimate active moments by muscles, passive moments by connective tissues and joint contact forces in the foot joints during walking. Joint kinematics and external forces of ten healthy subjects (all males, 24.7 ± 1.2 years) were acquired during walking. The data were entered into the five-segment musculoskeletal foot model to calculate muscle forces and joint contact forces of the foot joints using an inverse dynamics-based optimization. Joint reaction forces and active, passive and net moments of each joint were calculated from muscle and ligament forces. The maximum joint reaction forces were 8.72, 4.31, 2.65, and 3.41 body weight (BW) for the ankle, Chopart's, Lisfranc and metatarsophalangeal joints, respectively. Active and passive moments along with net moments were also obtained. The maximum net moments were 8.6, 8.4, 5.4 and 0.8%BW∙HT, respectively. While the trend of net moment was very similar between the four joints, the magnitudes and directions of the active and passive moments varied between joints. The active and passive moments during walking could reveal the roles of muscles and ligaments in each of the foot joints, which was not obvious in the net moment. This method may help narrow down the source of joint problems if applied to clinical studies. Copyright © 2018 Elsevier Ltd. All rights reserved.

Characterization of the biomechanical properties of T4 pili expressed by Streptococcus pneumoniae--a comparison between helix-like and open coil-like pili.

PubMed

Castelain, Mickaël; Koutris, Efstratios; Andersson, Magnus; Wiklund, Krister; Björnham, Oscar; Schedin, Staffan; Axner, Ove

2009-07-13

Bacterial adhesion organelles, known as fimbria or pili, are expressed by gram-positive as well as gram-negative bacteria families. These appendages play a key role in the first steps of the invasion and infection processes, and they therefore provide bacteria with pathogenic abilities. To improve the knowledge of pili-mediated bacterial adhesion to host cells and how these pili behave under the presence of an external force, we first characterize, using force measuring optical tweezers, open coil-like T4 pili expressed by gram-positive Streptococcus pneumoniae with respect to their biomechanical properties. It is shown that their elongation behavior can be well described by the worm-like chain model and that they possess a large degree of flexibility. Their properties are then compared with those of helix-like pili expressed by gram-negative uropathogenic Escherichia coli (UPEC), which have different pili architecture. The differences suggest that these two types of pili have distinctly dissimilar mechanisms to adhere and sustain external forces. Helix-like pili expressed by UPEC bacteria adhere to host cells by single adhesins located at the distal end of the pili while their helix-like structures act as shock absorbers to dampen the irregularly shear forces induced by urine flow and to increase the cooperativity of the pili ensemble, whereas open coil-like pili expressed by S. pneumoniae adhere to cells by a multitude of adhesins distributed along the pili. It is hypothesized that these two types of pili represent different strategies of adhering to host cells in the presence of external forces. When exposed to significant forces, bacteria expressing helix-like pili remain attached by distributing the external force among a multitude of pili, whereas bacteria expressing open coil-like pili sustain large forces primarily by their multitude of binding adhesins which presumably detach sequentially.

Unfolding DNA condensates produced by DNA-like charged depletants: A force spectroscopy study

NASA Astrophysics Data System (ADS)

Lima, C. H. M.; Rocha, M. S.; Ramos, E. B.

2017-02-01

In this work, we have measured, by means of optical tweezers, forces acting on depletion-induced DNA condensates due to the presence of the DNA-like charged protein bovine serum albumin (BSA). The stretching and unfolding measurements performed on the semi-flexible DNA chain reveal (1) the softening of the uncondensed DNA contour length and (2) a mechanical behavior strikingly different from those previously observed: the force-extension curves of BSA-induced DNA condensates lack the "saw-tooth" pattern and applied external forces as high as ≈80 pN are unable to fully unfold the condensed DNA contour length. This last mechanical experimental finding is in agreement with force-induced "unpacking" detailed Langevin dynamics simulations recently performed by Cortini et al. on model rod-like shaped condensates. Furthermore, a simple thermodynamics analysis of the unfolding process has enabled us to estimate the free energy involved in the DNA condensation: the estimated depletion-induced interactions vary linearly with both the condensed DNA contour length and the BSA concentration, in agreement with the analytical and numerical analysis performed on model DNA condensates. We hope that future additional experiments can decide whether the rod-like morphology is the actual one we are dealing with (e.g. pulling experiments coupled with super-resolution fluorescence microscopy).

Receptivity of a precessing vortex core to open-loop forcing in a swirling jet and its predictability by linear stability adjoint theory

NASA Astrophysics Data System (ADS)

Müller, Jens; Lückoff, Finn; Oberleithner, Kilian

2017-11-01

The precessing vortex core (PVC) is a dominant coherent structure which occurs in swirling jets such as in swirl-stabilised gas turbine combustors. It stems from a global hydrodynamic instability caused by an internal feedback mechanism within the jet core. In this work, open-loop forcing is applied to a generic non-reacting swirling jet to investigate its receptivity to external actuation regarding lock-in behaviour of the PVC for different streamwise positions and Reynolds numbers. The forcing is periodically exerted by zero net mass flux synthetic jets which are introduced radially through slits inside the duct walls upstream of the swirling jet's exit plane. Time-resolved pressure measurements are conducted to identify the PVC frequency and stereo PIV combined with proper orthogonal decomposition in the duct and free field is used to extract the mean flow and the PVC mode. The data is used in a global linear stability framework to gain the adjoint of the PVC which reveals the regions of highest receptivity to periodic forcing based on mean flow input only. This theoretical receptivity model is compared with the experimentally obtained receptivity results and the validity and applicability of the adjoint model for the prediction of optimal forcing positions is discussed.

Comparative Analysis of the Tour Jete and Aerial with Detailed Analysis of Aerial Takeoff Mechanics

NASA Astrophysics Data System (ADS)

Pierson, Mimi; Coplin, Kim

2006-10-01

Whether internally as muscle tension or from external sources, forces are necessary for all motion. This research focused on athletic rotations where conditions of flight are established during takeoff. By studying reaction forces that produce torques, moments of inertia, and linear and angular differences between distinct rotations around different principle axes of the body (tour jete in ballet - longitudinal axis; aerial in gymnastics - anteroposterior axis), and by looking at the values of angular momentum in the specific mechanics of aerial takeoff, we can gain insight into possible causes of injury, flaws in technique and limitations of athletes. Results showed significant differences in the horizontal and vertical components of takeoff between the tour jete and the aerial, and a realization that torque was produced in different biomechanical planes. Both rotations showed braking forces before takeoff to counteract forward momentum and increase vertical lift, but the angle of applied force varied, and the horizontal components of velocity and force and vertical velocity as well as moment of inertia throughout flight were consistently greater for the aerial. Breakdown of aerial takeoff highlighted the relative importance of the takeoff phases, showing that completion depends fundamentally upon the rotation of the rear foot and torso twisting during takeoff rather than the last foot in contact with the ground.

Quantifying the effect of electric current on cell adhesion studied by single-cell force spectroscopy.

PubMed

Jaatinen, Leena; Young, Eleanore; Hyttinen, Jari; Vörös, János; Zambelli, Tomaso; Demkó, László

2016-03-20

This study presents the effect of external electric current on the cell adhesive and mechanical properties of the C2C12 mouse myoblast cell line. Changes in cell morphology, viability, cytoskeleton, and focal adhesion structure were studied by standard staining protocols, while single-cell force spectroscopy based on the fluidic force microscopy technology provided a rapid, serial quantification and detailed analysis of cell adhesion and its dynamics. The setup allowed measurements of adhesion forces up to the μN range, and total detachment distances over 40 μm. Force-distance curves have been fitted with a simple elastic model including a cell detachment protocol in order to estimate the Young's modulus of the cells, as well as to reveal changes in the dynamic properties as functions of the applied current dose. While the cell spreading area decreased monotonously with increasing current doses, small current doses resulted only in differences related to cell elasticity. Current doses above 11 As/m(2), however, initiated more drastic changes in cell morphology, viability, cellular structure, as well as in properties related to cell adhesion. The observed differences, eventually leading to cell death toward higher doses, might originate from both the decrease in pH and the generation of reactive oxygen species.

Displacement and force coupling control design for automotive active front steering system

NASA Astrophysics Data System (ADS)

Zhao, Wanzhong; Zhang, Han; Li, Yijun

2018-06-01

A displacement and force coupling control design for active front steering (AFS) system of vehicle is proposed in this paper. In order to investigate the displacement and force characteristics of the AFS system of the vehicle, the models of AFS system, vehicle, tire as well as the driver model are introduced. Then, considering the nonlinear characteristics of the tire force and external disturbance, a robust yaw rate control method is designed by applying a steering motor to generate an active steering angle to adjust the yaw stability of the vehicle. Based on mixed H2/H∞ control, the system robustness and yaw rate tracking performance are enforced by H∞ norm constraint and the control effort is captured through H2 norm. In addition, based on the AFS system, a planetary gear set and an assist motor are both added to realize the road feeling control in this paper to dismiss the influence of extra steering angle through a compensating method. Evaluation of the overall system is accomplished by simulations and experiments under various driving condition. The simulation and experiment results show the proposed control system has excellent tracking performance and road feeling performance, which can improve the cornering stability and maneuverability of vehicle.

Lethal factor unfolding is the most force-dependent step of anthrax toxin translocation

PubMed Central

Thoren, Katie L.; Worden, Evan J.; Yassif, Jaime M.; Krantz, Bryan A.

2009-01-01

Cellular compartmentalization requires machinery capable of translocating polypeptides across membranes. In many cases, transported proteins must first be unfolded by means of the proton motive force and/or ATP hydrolysis. Anthrax toxin, which is composed of a channel-forming protein and two substrate proteins, is an attractive model system to study translocation-coupled unfolding, because the applied driving force can be externally controlled and translocation can be monitored directly by using electrophysiology. By controlling the driving force and introducing destabilizing point mutations in the substrate, we identified the barriers in the transport pathway, determined which barrier corresponds to protein unfolding, and mapped how the substrate protein unfolds during translocation. In contrast to previous studies, we find that the protein's structure next to the signal tag is not rate-limiting to unfolding. Instead, a more extensive part of the structure, the amino-terminal β-sheet subdomain, must disassemble to cross the unfolding barrier. We also find that unfolding is catalyzed by the channel's phenylalanine-clamp active site. We propose a broad molecular mechanism for translocation-coupled unfolding, which is applicable to both soluble and membrane-embedded unfolding machines. PMID:19926859

Dynamical diagnostics of the SST annual cycle in the eastern equatorial Pacific: part I a linear coupled framework

NASA Astrophysics Data System (ADS)

Chen, Ying-Ying; Jin, Fei-Fei

2018-03-01

The eastern equatorial Pacific has a pronounced westward propagating SST annual cycle resulting from ocean-atmosphere interactions with equatorial semiannual solar forcing and off-equatorial annual solar forcing conveyed to the equator. In this two-part paper, a simple linear coupled framework is proposed to quantify the internal dynamics and external forcing for a better understanding of the linear part of the dynamics annual cycle. It is shown that an essential internal dynamical factor is the SST damping rate which measures the coupled stability in a similar way as the Bjerknes instability index for the El Niño-Southern Oscillation. It comprises three major negative terms (dynamic damping due to the Ekman pumping feedback, mean circulation advection, and thermodynamic feedback) and two positive terms (thermocline feedback and zonal advection). Another dynamical factor is the westward-propagation speed that is mainly determined by the thermodynamic feedback, the Ekman pumping feedback, and the mean circulation. The external forcing is measured by the annual and semiannual forcing factors. These linear internal and external factors, which can be estimated from data, determine the amplitude of the annual cycle.

Detection and characterization of elongated bubbles and drops in two-phase flow using magnetic fields

NASA Astrophysics Data System (ADS)

Wiederhold, A.; Boeck, T.; Resagk, C.

2017-08-01

We report a method to detect and to measure the size and velocity of elongated bubbles or drops in a dispersed two-phase flow. The difference of the magnetic susceptibilities between two phases causes a force on the interface between both phases when it is exposed to an external magnetic field. The force is measured with a state-of-the-art electromagnetic compensation balance. While the front and the back of the bubble pass the magnetic field, two peaks in the force signal appear, which can be used to calculate the velocity and geometry parameters of the bubble. We achieve a substantial advantage over other bubble detection techniques because this technique is contactless, non-invasive, independent of the electrical conductivity and can be applied to opaque or aggressive fluids. The measurements are performed in an inclined channel with air bubbles and paraffin oil drops in water. The bubble length is in the range of 0.1-0.25 m and the bubble velocity lies between 0.02-0.22 m s-1. Furthermore we show that it is possible to apply this measurement principle for nondestructive testing (NDT) of diamagnetic and paramagnetic materials like metal, plastics or glass, provided that defects are in the range of 10‒2 m. This technique opens up new possibilities in industrial applications to measure two-phase flow parameters and in material testing.

A musculoskeletal shoulder model based on pseudo-inverse and null-space optimization.

PubMed

Terrier, Alexandre; Aeberhard, Martin; Michellod, Yvan; Mullhaupt, Philippe; Gillet, Denis; Farron, Alain; Pioletti, Dominique P

2010-11-01

The goal of the present work was assess the feasibility of using a pseudo-inverse and null-space optimization approach in the modeling of the shoulder biomechanics. The method was applied to a simplified musculoskeletal shoulder model. The mechanical system consisted in the arm, and the external forces were the arm weight, 6 scapulo-humeral muscles and the reaction at the glenohumeral joint, which was considered as a spherical joint. The muscle wrapping was considered around the humeral head assumed spherical. The dynamical equations were solved in a Lagrangian approach. The mathematical redundancy of the mechanical system was solved in two steps: a pseudo-inverse optimization to minimize the square of the muscle stress and a null-space optimization to restrict the muscle force to physiological limits. Several movements were simulated. The mathematical and numerical aspects of the constrained redundancy problem were efficiently solved by the proposed method. The prediction of muscle moment arms was consistent with cadaveric measurements and the joint reaction force was consistent with in vivo measurements. This preliminary work demonstrated that the developed algorithm has a great potential for more complex musculoskeletal modeling of the shoulder joint. In particular it could be further applied to a non-spherical joint model, allowing for the natural translation of the humeral head in the glenoid fossa. Copyright © 2010 IPEM. Published by Elsevier Ltd. All rights reserved.

Spin-orbit induced electronic spin separation in semiconductor nanostructures.

PubMed

Kohda, Makoto; Nakamura, Shuji; Nishihara, Yoshitaka; Kobayashi, Kensuke; Ono, Teruo; Ohe, Jun-ichiro; Tokura, Yasuhiro; Mineno, Taiki; Nitta, Junsaku

2012-01-01

The demonstration of quantized spin splitting by Stern and Gerlach is one of the most important experiments in modern physics. Their discovery was the precursor of recent developments in spin-based technologies. Although electrical spin separation of charged particles is fundamental in spintronics, in non-uniform magnetic fields it has been difficult to separate the spin states of charged particles due to the Lorentz force, as well as to the insufficient and uncontrollable field gradients. Here we demonstrate electronic spin separation in a semiconductor nanostructure. To avoid the Lorentz force, which is inevitably induced when an external magnetic field is applied, we utilized the effective non-uniform magnetic field which originates from the Rashba spin-orbit interaction in an InGaAs-based heterostructure. Using a Stern-Gerlach-inspired mechanism, together with a quantum point contact, we obtained field gradients of 10(8) T m(-1) resulting in a highly polarized spin current.

Spin–orbit induced electronic spin separation in semiconductor nanostructures

PubMed Central

Kohda, Makoto; Nakamura, Shuji; Nishihara, Yoshitaka; Kobayashi, Kensuke; Ono, Teruo; Ohe, Jun-ichiro; Tokura, Yasuhiro; Mineno, Taiki; Nitta, Junsaku

2012-01-01

The demonstration of quantized spin splitting by Stern and Gerlach is one of the most important experiments in modern physics. Their discovery was the precursor of recent developments in spin-based technologies. Although electrical spin separation of charged particles is fundamental in spintronics, in non-uniform magnetic fields it has been difficult to separate the spin states of charged particles due to the Lorentz force, as well as to the insufficient and uncontrollable field gradients. Here we demonstrate electronic spin separation in a semiconductor nanostructure. To avoid the Lorentz force, which is inevitably induced when an external magnetic field is applied, we utilized the effective non-uniform magnetic field which originates from the Rashba spin–orbit interaction in an InGaAs-based heterostructure. Using a Stern–Gerlach-inspired mechanism, together with a quantum point contact, we obtained field gradients of 108 T m−1 resulting in a highly polarized spin current. PMID:23011136

Velocity-Field Measurements of an Axisymmetric Separated Flow Subjected to Amplitude-Modulated Excitation

NASA Technical Reports Server (NTRS)

Trosin, Barry James

2007-01-01

Active flow control was applied at the point of separation of an axisymmetric, backward-facing-step flow. The control was implemented by employing a Helmholtz resonator that was externally driven by an amplitude-modulated, acoustic disturbance from a speaker located upstream of the wind tunnel. The velocity field of the separating/reattaching flow region downstream of the step was characterized using hotwire velocity measurements with and without flow control. Conventional statistics of the data reveal that the separating/reattaching flow is affected by the imposed forcing. Triple decomposition along with conditional averaging was used to distinguish periodic disturbances from random turbulence in the fluctuating velocity component. A significant outcome of the present study is that it demonstrates that amplitude-modulated forcing of the separated flow alters the flow in the same manner as the more conventional method of periodic excitation.

Long-Range Interactions Restrict Water Transport in Pyrophyllite Interlayers

PubMed Central

Zarzycki, Piotr; Gilbert, Benjamin

2016-01-01

Water diffusion within smectite clay interlayers is reduced by confinement and hence is highly determined by the interlayer spacings that are adopted during swelling. However, a molecular understanding of the short- and long-range forces governing interlayer water structure and dynamics is lacking. Using molecular dynamics simulations of water intercalated between pyrophyllite (smectite prototype) layers we provide a detailed picture of the variation of interlayered water mobility accompanying smectite expansion. Subtle changes in hydrogen bond network structure cause significant changes in water mobility that is greater for stable hydration states and reduced for intermediate separations. By studying pyrophyllite with and without external water we reveal that long-range electrostatic forces apply a restraining effect upon interlayer water mobility. Our findings are relevant for broad range of confining nanostructures with walls thin enough to permit long-range interactions that could affect the mobility of confined solvent molecules and solute species. PMID:27118164

Robust tilt and lock mechanism for hopping actuator

DOE Office of Scientific and Technical Information (OSTI.GOV)

Salton, Jonathan R.; Buerger, Stephen; Dullea, Kevin J.

A tilt and lock apparatus that includes a tilt servomechanism, a spiral torsion spring, a lock wheel, and a lock hook is described herein. The spiral torsion spring is mechanically coupled to the tilt servomechanism and the lock wheel (which includes an opening). When a shaft is positioned through the opening, rotation of the lock wheel is in unison with rotation of the shaft. An external surface of the lock wheel includes one or more grooves. The lock hook includes a head that engages and disengages the grooves. The lock wheel is stationary when the head engages one of themore » grooves and is rotatable when the head disengages the grooves. The head and the grooves are geometrically aligned when engaged to prevent creation of a force that acts to disengage the head responsive to an applied force acting on the shaft.« less

Observations reveal external driver for Arctic sea-ice retreat

NASA Astrophysics Data System (ADS)

Notz, Dirk; Marotzke, Jochem

2012-04-01

The very low summer extent of Arctic sea ice that has been observed in recent years is often casually interpreted as an early-warning sign of anthropogenic global warming. For examining the validity of this claim, previously IPCC model simulations have been used. Here, we focus on the available observational record to examine if this record allows us to identify either internal variability, self-acceleration, or a specific external forcing as the main driver for the observed sea-ice retreat. We find that the available observations are sufficient to virtually exclude internal variability and self-acceleration as an explanation for the observed long-term trend, clustering, and magnitude of recent sea-ice minima. Instead, the recent retreat is well described by the superposition of an externally forced linear trend and internal variability. For the externally forced trend, we find a physically plausible strong correlation only with increasing atmospheric CO2 concentration. Our results hence show that the observed evolution of Arctic sea-ice extent is consistent with the claim that virtually certainly the impact of an anthropogenic climate change is observable in Arctic sea ice already today.

Investigation of shock-acoustic-wave interaction in transonic flow

NASA Astrophysics Data System (ADS)

Feldhusen-Hoffmann, Antje; Statnikov, Vladimir; Klaas, Michael; Schröder, Wolfgang

2018-01-01

The buffet flow field around supercritical airfoils is dominated by self-sustained shock wave oscillations on the suction side of the wing. Theories assume that this unsteadiness is driven by an acoustic feedback loop of disturbances in the flow field downstream of the shock wave whose upstream propagating part is generated by acoustic waves. Therefore, in this study, first variations in the sound pressure level of the airfoil's trailing-edge noise during a buffet cycle, which force the shock wave to move upstream and downstream, are detected, and then, the sensitivity of the shock wave oscillation during buffet to external acoustic forcing is analyzed. Time-resolved standard and tomographic particle-image velocimetry (PIV) measurements are applied to investigate the transonic buffet flow field over a supercritical DRA 2303 airfoil. The freestream Mach number is M_{∞} = 0.73, the angle of attack is α = {3.5}°, and the chord-based Reynolds number is Re_c = 1.9× 10^6. The perturbed Lamb vector field, which describes the major acoustic source term of trailing-edge noise, is determined from the tomographic PIV data. Subsequently, the buffet flow field is disturbed by an artificially generated acoustic field, the acoustic intensity of which is comparable to the Lamb vector that is determined from the PIV data. The results confirm the hypothesis that buffet is driven by an acoustic feedback loop and show the shock wave oscillation to directly respond to external acoustic forcing. That is, the amplitude modulation frequency of the artificial acoustic perturbation determines the shock oscillation.

van der Waals torque

NASA Astrophysics Data System (ADS)

Esquivel-Sirvent, Raul; Schatz, George

2014-03-01

The theory of generalized van der Waals forces by Lifshtz when applied to optically anisotropic media predicts the existence of a torque. In this work we present a theoretical calculation of the van der Waals torque for two systems. First we consider two isotropic parallel plates where the anisotropy is induced using an external magnetic field. The anisotropy will in turn induce a torque. As a case study we consider III-IV semiconductors such as InSb that can support magneto plasmons. The calculations of the torque are done in the Voigt configuration, that occurs when the magnetic field is parallel to the surface of the slabs. The change in the dielectric function as the magnetic field increases has the effect of decreasing the van der Waals force and increasing the torque. Thus, the external magnetic field is used to tune both the force and torque. The second example we present is the use of the torque in the non retarded regime to align arrays of nano particle slabs. The torque is calculated within Barash and Ginzburg formalism in the nonretarded limit, and is quantified by the introduction of a Hamaker torque constant. Calculations are conducted between anisotropic slabs of materials including BaTiO3 and arrays of Ag nano particles. Depending on the shape and arrangement of the Ag nano particles the effective dielectric function of the array can be tuned as to make it more or less anisotropic. We show how this torque can be used in self assembly of arrays of nano particles. ref. R. Esquivel-Sirvent, G. C. Schatz, Phys. Chem C, 117, 5492 (2013). partial support from DGAPA-UNAM.

Counterrotating-Shoulder Mechanism for Friction Stir Welding

NASA Technical Reports Server (NTRS)

Nunes, Arthur C., Jr.

2007-01-01

A counterrotating-shoulder mechanism has been proposed as an alternative to the mechanism and fixtures used in conventional friction stir welding. The mechanism would internally react most or all of the forces and torques exerted on the workpiece, making it unnecessary to react the forces and torques through massive external fixtures. In conventional friction stir welding, a rotating pin tool is inserted into, and moved along, a weld seam. As the pin tool moves, it stirs together material from the opposite sides of the seam to form the weld. A large axial plunge force must be exerted upon the workpiece through and by the pin tool and a shoulder attached above the pin tool in order to maintain the pressure necessary for the process. The workpiece is secured on top of an anvil, which supports the workpiece against the axial plunge force and against the torque exerted by the pin tool and shoulder. The anvil and associated fixtures must be made heavy (and, therefore, are expensive) to keep the workpiece stationary. In addition, workpiece geometries must be limited to those that can be accommodated by the fixtures. The predecessor of the proposed counterrotating-shoulder mechanism is a second-generation, self-reacting tool, resembling a bobbin, that makes it possible to dispense with the heavy anvil. This tool consists essentially of a rotating pin tool with opposing shoulders. Although the opposing shoulders maintain the necessary pressure without need to externally apply or react a large plunge force, the torque exerted on the workpiece remains unreacted in the absence of a substantial external fixture. Depending on the RPM and the thickness of the workpiece, the torque can be large. The proposed mechanism (see figure) would include a spindle attached to a pin tool with a lower shoulder. The spindle would be coupled via splines to the upper one of three bevel gears in a differential drive. The middle bevel gear would be the power-input gear and would be coupled to the upper and lower bevel gears. The lower bevel gear would be attached to the upper shoulder and would slide and rotate freely over the spindle. The spindle would be fastened by its threaded upper end to an external submechanism that would exert axial tension on the spindle to load the workpiece in compression between the shoulders. By reducing or eliminating (relative to the use of a self reacting tool) the torque that must be reacted externally, the use of the proposed tool would reduce the tendency toward distortion or slippage of the workpiece. To begin a weld, the spindle would be inserted through a hole in the workpiece or run-on tab at the beginning of the seam and fastened to the loading submechanism. Rotation and axial loading would be increased gradually from zero and, after a time to be determined by trial and error, translation along the weld seam would be increased gradually from zero to a steady weld speed. The weld would be ended by running the mechanism off the workpiece or, if the lower shoulder were detachable, by detaching the lower shoulder from the spindle and pulling the pin tool out.

Amplitude and phase fluctuations of Van der Pol oscillator under external random forcing

NASA Astrophysics Data System (ADS)

Singh, Aman K.; Yadava, R. D. S.

2018-05-01

The paper presents an analytical study of noise in Van der Pol oscillator output subjected to an external force noise assumed to be characterized by delta function (white noise). The external fluctuations are assumed to be small in comparison to the average response of the noise free system. The autocorrelation function and power spectrum are calculated under the condition of weak nonlinearity. The latter ensures limit cycle oscillations. The total spectral power density is dominated by the contributions from the phase fluctuations. The amplitude fluctuations are at least two orders of magnitude smaller. The analysis is shown to be useful to interpretation microcantilever based biosensing data.

Inducing and destruction of chimeras and chimera-like states by an external harmonic force

NASA Astrophysics Data System (ADS)

Shepelev, I. A.; Vadivasova, T. E.

2018-03-01

We study the phenomena of chimera destruction and inducing of chimera-like states in an ensemble of nonlocally coupled chaotic Rössler oscillators under an external harmonic force. The localized harmonic influence can lead to both destruction and changing of the spatial topology of chimeras. At the same time this influence can cause the emergence of stable chimera-like states (induced chimeras) for the regime of partial coherent chaos. Induced chimeras are also observed for the global influence. We show the possibility of controlling the chimera-like state topology by varying the parameters of localized external harmonic influence.

The Veterans Administration library program.

PubMed

Gartland, H J

1968-01-01

The Veterans Administration Library Service is continuously responsive to the information requirements of the agency's policies which provide for the improved care and treatment of veterans through research, education, and clinical programs. At the same time, it participates in the planning of the federal government as a whole in providing library support for health care for the American people. There are both internal and external forces influencing VA hospitals and their libraries. Retirements and consequent recruitment of new people will necessitate a rethinking of the VA library program at the same time as external forces will be affecting the program. These external forces include the application of machines to library services through the development of in-house capabilities coupled with joint-use participation and P.L. 89-785 which provides for the exchange of medical information, sharing of facilities, and cooperative training programs. A conceptual rearrangement of information resources will facilitate attainment of our goals.

Transient Reactivation of a Deep-Seated Landslide by Undrained Loading Captured With Repeat Airborne and Terrestrial Lidar

NASA Astrophysics Data System (ADS)

Booth, Adam M.; McCarley, Justin; Hinkle, Jason; Shaw, Susan; Ampuero, Jean-Paul; Lamb, Michael P.

2018-05-01

Landslides reactivate due to external environmental forcing or internal mass redistribution, but the process is rarely documented quantitatively. We capture the three-dimensional, 1-m resolution surface deformation field of a transiently reactivated landslide with image correlation of repeat airborne lidar. Undrained loading by two debris flows in the landslide's head, rather than external forcing, triggered reactivation. After that loading, the lower 2 km of the landslide advanced by up to 14 m in 2 years before completely stopping. The displacement field over those 2 years implies that the slip surface gained 1 kPa of shear strength, which was likely accomplished by a negative dilatancy-pore pressure feedback as material deformed around basal roughness elements. Thus, landslide motion can be decoupled from external environmental forcing in cases, motivating the need to better understand internal perturbations to the stress field to predict hazards and sediment fluxes as landscapes evolve.

Tibiofemoral Contact Forces in the Anterior Cruciate Ligament-Reconstructed Knee.

PubMed

Saxby, David John; Bryant, Adam L; Modenese, Luca; Gerus, Pauline; Killen, Bryce A; Konrath, Jason; Fortin, Karine; Wrigley, Tim V; Bennell, Kim L; Cicuttini, Flavia M; Vertullo, Christopher; Feller, Julian A; Whitehead, Tim; Gallie, Price; Lloyd, David G

2016-11-01

To investigate differences in anterior cruciate ligament-reconstructed (ACLR) and healthy individuals in terms of the magnitude of the tibiofemoral contact forces, as well as the relative muscle and external load contributions to those contact forces, during walking, running, and sidestepping gait tasks. A computational EMG-driven neuromusculoskeletal model was used to estimate the muscle and tibiofemoral contact forces in those with single-bundle combined semitendinosus and gracilis tendon autograft ACLR (n = 104, 29.7 ± 6.5 yr, 78.1 ± 14.4 kg) and healthy controls (n = 60, 27.5 ± 5.4 yr, 67.8 ± 14.0 kg) during walking (1.4 ± 0.2 m·s), running (4.5 ± 0.5 m·s) and sidestepping (3.7 ± 0.6 m·s). Within the computational model, the semitendinosus of ACLR participants was adjusted to account for literature reported strength deficits and morphological changes subsequent to autograft harvesting. ACLR had smaller maximum total and medial tibiofemoral contact forces (~80% of control values, scaled to bodyweight) during the different gait tasks. Compared with controls, ACLR were found to have a smaller maximum knee flexion moment, which explained the smaller tibiofemoral contact forces. Similarly, compared with controls, ACLR had both a smaller maximum knee flexion angle and knee flexion excursion during running and sidestepping, which may have concentrated the articular contact forces to smaller areas within the tibiofemoral joint. Mean relative muscle and external load contributions to the tibiofemoral contact forces were not significantly different between ACLR and controls. ACLR had lower bodyweight-scaled tibiofemoral contact forces during walking, running, and sidestepping, likely due to lower knee flexion moments and straighter knee during the different gait tasks. The relative contributions of muscles and external loads to the contact forces were equivalent between groups.

Empirical model of TEC response to geomagnetic and solar forcing over Balkan Peninsula

NASA Astrophysics Data System (ADS)

Mukhtarov, P.; Andonov, B.; Pancheva, D.

2018-01-01

An empirical total electron content (TEC) model response to external forcing over Balkan Peninsula (35°N-50°N; 15°E-30°E) is built by using the Center for Orbit Determination of Europe (CODE) TEC data for full 17 years, January 1999 - December 2015. The external forcing includes geomagnetic activity described by the Kp-index and solar activity described by the solar radio flux F10.7. The model describes the most probable spatial distribution and temporal variability of the externally forced TEC anomalies assuming that they depend mainly on latitude, Kp-index, F10.7 and LT. The anomalies are expressed by the relative deviation of the TEC from its 15-day mean, rTEC, as the mean value is calculated from the 15 preceding days. The approach for building this regional model is similar to that of the global TEC model reported by Mukhtarov et al. (2013a) however it includes two important improvements related to short-term variability of the solar activity and amended geomagnetic forcing by using a "modified" Kp index. The quality assessment of the new constructing model procedure in terms of modeling error calculated for the period of 1999-2015 indicates significant improvement in accordance with the global TEC model (Mukhtarov et al., 2013a). The short-term prediction capabilities of the model based on the error calculations for 2016 are improved as well. In order to demonstrate how the model is able to reproduce the rTEC response to external forcing three geomagnetic storms, accompanied also with short-term solar activity variations, which occur at different seasons and solar activity conditions are presented.

Magnetically controlled ferromagnetic swimmers

PubMed Central

Hamilton, Joshua K.; Petrov, Peter G.; Winlove, C. Peter; Gilbert, Andrew D.; Bryan, Matthew T.; Ogrin, Feodor Y.

2017-01-01

Microscopic swimming devices hold promise for radically new applications in lab-on-a-chip and microfluidic technology, diagnostics and drug delivery etc. In this paper, we demonstrate the experimental verification of a new class of autonomous ferromagnetic swimming devices, actuated and controlled solely by an oscillating magnetic field. These devices are based on a pair of interacting ferromagnetic particles of different size and different anisotropic properties joined by an elastic link and actuated by an external time-dependent magnetic field. The net motion is generated through a combination of dipolar interparticle gradient forces, time-dependent torque and hydrodynamic coupling. We investigate the dynamic performance of a prototype (3.6 mm) of the ferromagnetic swimmer in fluids of different viscosity as a function of the external field parameters (frequency and amplitude) and demonstrate stable propulsion over a wide range of Reynolds numbers. We show that the direction of swimming has a dependence on both the frequency and amplitude of the applied external magnetic field, resulting in robust control over the speed and direction of propulsion. This paves the way to fabricating microscale devices for a variety of technological applications requiring reliable actuation and high degree of control. PMID:28276490

Magnetically controlled ferromagnetic swimmers

NASA Astrophysics Data System (ADS)

Hamilton, Joshua K.; Petrov, Peter G.; Winlove, C. Peter; Gilbert, Andrew D.; Bryan, Matthew T.; Ogrin, Feodor Y.

2017-03-01

Microscopic swimming devices hold promise for radically new applications in lab-on-a-chip and microfluidic technology, diagnostics and drug delivery etc. In this paper, we demonstrate the experimental verification of a new class of autonomous ferromagnetic swimming devices, actuated and controlled solely by an oscillating magnetic field. These devices are based on a pair of interacting ferromagnetic particles of different size and different anisotropic properties joined by an elastic link and actuated by an external time-dependent magnetic field. The net motion is generated through a combination of dipolar interparticle gradient forces, time-dependent torque and hydrodynamic coupling. We investigate the dynamic performance of a prototype (3.6 mm) of the ferromagnetic swimmer in fluids of different viscosity as a function of the external field parameters (frequency and amplitude) and demonstrate stable propulsion over a wide range of Reynolds numbers. We show that the direction of swimming has a dependence on both the frequency and amplitude of the applied external magnetic field, resulting in robust control over the speed and direction of propulsion. This paves the way to fabricating microscale devices for a variety of technological applications requiring reliable actuation and high degree of control.

Shaping magnetic fields to direct therapy to ears and eyes.

PubMed

Shapiro, B; Kulkarni, S; Nacev, A; Sarwar, A; Preciado, D; Depireux, D A

2014-07-11

Magnetic fields have the potential to noninvasively direct and focus therapy to disease targets. External magnets can apply forces on drug-coated magnetic nanoparticles, or on living cells that contain particles, and can be used to manipulate them in vivo. Significant progress has been made in developing and testing safe and therapeutic magnetic constructs that can be manipulated by magnetic fields. However, we do not yet have the magnet systems that can then direct those constructs to the right places, in vivo, over human patient distances. We do not yet know where to put the external magnets, how to shape them, or when to turn them on and off to direct particles or magnetized cells-in blood, through tissue, and across barriers-to disease locations. In this article, we consider ear and eye disease targets. Ear and eye targets are too deep and complex to be targeted by a single external magnet, but they are shallow enough that a combination of magnets may be able to direct therapy to them. We focus on how magnetic fields should be shaped (in space and time) to direct magnetic constructs to ear and eye targets.

Features of current-voltage characteristic of nonequilibrium trench MOS barrier Schottky diode

NASA Astrophysics Data System (ADS)

Mamedov, R. K.; Aslanova, A. R.

2018-06-01

The trench MOS barrier Schottky diodes (TMBS diode) under the influence of the voltage drop of the additional electric field (AEF) appearing in the near-contact region of the semiconductor are in a nonequilibrium state and their closed external circuit flows currents in the absence of an external voltage. When an external voltage is applied to the TMBS diode, the current transmission is described by the thermionic emission theory with a specific feature. Both forward and reverse I-V characteristics of the TMBS diode consist of two parts. In the initial first part of the forward I-V characteristic there are no forward currents, but reverse saturation currents flow, in its subsequent second part the currents increase exponentially with the voltage. In the initial first part of the reverse I-V characteristic, the currents increase in an abrupt way and in the subsequent second part the saturation currents flow under the action of the image force. The mathematical expressions for forward and reverse I-V characteristic of the TMBS diode and also narrow or nanostructure Schottky diode are proposed, which are in good agreement with the results of experimental and calculated I-V characteristics.

Electrically controlled adjustable-resistance exercise equipment employing magnetorheological fluid

NASA Astrophysics Data System (ADS)

Lukianovich, Alex; Ashour, Osama N.; Thurston, Wilbert L.; Rogers, Craig A.; Chaudhry, Zaffir A.

1996-05-01

Magnetorheological (MR) fluids consist of stable suspensions of magnetic particles in a carrying fluid. The magnetorheological effect is one of the direct influences on the mechanical properties of a fluid. It represents a reversible increase, due to an external magnetic field, of the effective viscosity. Besides the variation of the rheological properties (viscosity, elasticity, and plasticity), the magnetic properties of the fluid (permeability and susceptibility), as well as the thermal and acoustic properties, are strongly influenced when an external magnetic field is applied. MR fluids have many appealing applications in the area of vibration control. The distinguishing feature of any MR fluid device is the absence of moving mechanical parts and the extreme simplicity of construction and technology. The most important element of any MR fluid device is an MR valve, which is functionally a controllable hydraulic resistance. As a demonstration of such devices, two commercially available pieces of exercise equipment, a cross stepper and a bench press, were modified to incorporate MR fluid and an external MR valve. As the magnetic field strength operating across the MR valve is adjusted, the viscosity of the flowing MR fluid changes and, accordingly, the needed force is adjusted.

Electroosmotic flow of biorheological micropolar fluids through microfluidic channels

NASA Astrophysics Data System (ADS)

Chaube, Mithilesh Kumar; Yadav, Ashu; Tripathi, Dharmendra; Bég, O. Anwar

2018-05-01

An analytical analysis is presented in this work to assess the influence of micropolar nature of fluids in fully developed flow induced by electrokinetically driven peristaltic pumping through a parallel plate microchannel. The walls of the channel are assumed as sinusoidal wavy to analyze the peristaltic flow nature. We consider that the wavelength of the wall motion is much larger as compared to the channel width to validate the lubrication theory. To simplify the Poisson Boltzmann equation, we also use the Debye-Hückel linearization. We consider governing equation for micropolar fluid in absence of body force and couple effects however external electric field is employed. The solutions for axial velocity, spin velocity, flow rate, pressure rise, and stream functions subjected to given physical boundary conditions are computed. The effects of pertinent parameters like Debye length and Helmholtz-Smoluchowski velocity which characterize the EDL phenomenon and external electric field, coupling number and micropolar parameter which characterize the micropolar fluid behavior, on peristaltic pumping are discussed through the illustrations. The results show that peristaltic pumping may alter by applying external electric fields. This model can be used to design and engineer the peristalsis-lab-on-chip and micro peristaltic syringe pumps for biomedical applications.

The effect of an external electric field on the growth of incongruent-melting material

NASA Astrophysics Data System (ADS)

Uda, Satoshi; Huang, Xinming; Wang, Shou-Qi

2005-02-01

The significance of an electric field on the crystallization process is differentiated into two consequences; (i) thermodynamic effect and (ii) growth-dynamic effect. The former modifies the chemical potential of the associated phases which changes the equilibrium phase relationship while the latter influences the solute transport, growth kinetics, surface creation and defect generation during growth. The intrinsic electric field generating during growth is attributed to the crystallization-related electromotive force and the thermoelectric power driven by the temperature gradient at the interface which influences the solute transport and solute partitioning. The external electric field was applied to the growth apparatus in the ternary system of La2O3- Ga2O3- SiO2 so that the chemical potential of both solid and liquid phases changed leading to the variation of the equilibrium phase relationship. Imposing a 500 V/cm electric field on the system moved the boundary of primary phase field of lanthanum gallate ( LaGaO3) and Ga-bearing lanthanum silicate ( La14GaxSi9-xO) toward the SiO2 apex by 5 mol% which clearly demonstrated the change of the phase relationship by the external electric field.

Response statistics of rotating shaft with non-linear elastic restoring forces by path integration

NASA Astrophysics Data System (ADS)

Gaidai, Oleg; Naess, Arvid; Dimentberg, Michael

2017-07-01

Extreme statistics of random vibrations is studied for a Jeffcott rotor under uniaxial white noise excitation. Restoring force is modelled as elastic non-linear; comparison is done with linearized restoring force to see the force non-linearity effect on the response statistics. While for the linear model analytical solutions and stability conditions are available, it is not generally the case for non-linear system except for some special cases. The statistics of non-linear case is studied by applying path integration (PI) method, which is based on the Markov property of the coupled dynamic system. The Jeffcott rotor response statistics can be obtained by solving the Fokker-Planck (FP) equation of the 4D dynamic system. An efficient implementation of PI algorithm is applied, namely fast Fourier transform (FFT) is used to simulate dynamic system additive noise. The latter allows significantly reduce computational time, compared to the classical PI. Excitation is modelled as Gaussian white noise, however any kind distributed white noise can be implemented with the same PI technique. Also multidirectional Markov noise can be modelled with PI in the same way as unidirectional. PI is accelerated by using Monte Carlo (MC) estimated joint probability density function (PDF) as initial input. Symmetry of dynamic system was utilized to afford higher mesh resolution. Both internal (rotating) and external damping are included in mechanical model of the rotor. The main advantage of using PI rather than MC is that PI offers high accuracy in the probability distribution tail. The latter is of critical importance for e.g. extreme value statistics, system reliability, and first passage probability.

Position of the quadriceps actuator influences knee loads during simulated squat testing.

PubMed

Hast, Michael W; Piazza, Stephen J

2018-05-17

The "Oxford Rig" cadaveric simulator permits researchers and clinicians to study knee mechanics during a simulated squatting motion. The motion of the lower limb in the Oxford Rig is typically controlled by a single actuator that applies tension to the quadriceps tendon. The location of the quadriceps actuator, however, has differed across published descriptions of the Oxford Rig. Actuators have been placed on the femur and pelvis, and on "grounded" locations external to the specimen, but the consequences of this placement for knee kinematics and kinetics are unknown. The purpose of this study was to examine these effects using a validated computational musculoskeletal model. When the actuator was placed on the femur or pelvis, forces realistically increased with knee flexion, with quadriceps and patellofemoral contact forces exceeding 2000 N and 3000 N, respectively, at 100° flexion. When the actuator was grounded, however, forces were substantially reduced and did not monotonically increase with flexion. Articular joint contact forces were not strongly influenced by changing the location of the actuator from the femur to the pelvis, with small RMS differences in quadriceps forces (48.2 N), patellofemoral forces (83.6 N), and tibiofemoral forces (58.9 N) between these conditions. The location of the actuator did not substantially affect knee kinematics. The results of this study suggest that the quadriceps actuator of the Oxford Rig should be attached to either the femur or the pelvis when the goal is to make realistic estimates of quadriceps forces and articular contact forces within the knee joint. Copyright © 2018 Elsevier Ltd. All rights reserved.

Limitations of differential electrophoresis for measuring colloidal forces: a Brownian dynamics study.

PubMed

Holtzer, Gretchen L; Velegol, Darrell

2005-10-25

Differential electrophoresis experiments are often used to measure subpiconewton forces between two spheres of a heterodoublet. The experiments have been interpreted by solving the electrokinetic equations to obtain a simple Stokes law-type equation. However, for nanocolloids, the effects of Brownian motion alter the interpretation: (1) Brownian translation changes the rate of axial separation. (2) Brownian rotation reduces the alignment of the doublet with the applied electric field. (3) Particles can reaggregate by Brownian motion after they break, forming either heterodoublets or homodoublets, and because homodoublets cannot be broken by differential electrophoresis, this effectively terminates the experiment. We tackle points 1 and 2 using Brownian dynamics simulations (BDS) with electrophoresis as an external force, accounting for convective translation and rotation as well as Brownian translation and rotation. Our simulations identify the lower particle size limit of differential electrophoresis to be about 1 microm for desired statistical accuracy. Furthermore, our simulations predict that particles around 10 nm in size and at ambient conditions will break primarily by Brownian motion, with a negligible effect due to the electric field.

Inverse and Direct Energy Cascades in Three-Dimensional Magnetohydrodynamic Turbulence at Low Magnetic Reynolds Number

NASA Astrophysics Data System (ADS)

Baker, Nathaniel T.; Pothérat, Alban; Davoust, Laurent; Debray, François

2018-06-01

This experimental study analyzes the relationship between the dimensionality of turbulence and the upscale or downscale nature of its energy transfers. We do so by forcing low-R m magnetohydrodynamic turbulence in a confined channel, while precisely controlling its dimensionality by means of an externally applied magnetic field. We first identify a specific length scale l^⊥ c that separates smaller 3D structures from larger quasi-2D ones. We then show that an inverse energy cascade of horizontal kinetic energy along horizontal scales is always observable at large scales, and that it extends well into the region of 3D structures. At the same time, a direct energy cascade confined to the smallest and strongly 3D scales is observed. These dynamics therefore appear not to be simply determined by the dimensionality of individual scales, nor by the forcing scale, unlike in other studies. In fact, our findings suggest that the relationship between kinematics and dynamics is not universal and may strongly depend on the forcing and dissipating mechanisms at play.

Are muscle activation patterns altered during shod and barefoot running with a forefoot footfall pattern?

PubMed

Ervilha, Ulysses Fernandes; Mochizuki, Luis; Figueira, Aylton; Hamill, Joseph

2017-09-01

This study aimed to investigate the activation of lower limb muscles during barefoot and shod running with forefoot or rearfoot footfall patterns. Nine habitually shod runners were asked to run straight for 20 m at self-selected speed. Ground reaction forces and thigh and shank muscle surface electromyographic (EMG) were recorded. EMG outcomes (EMG intensity [iEMG], latency between muscle activation and ground reaction force, latency between muscle pairs and co-activation index between muscle pairs) were compared across condition (shod and barefoot), running cycle epochs (pre-strike, strike, propulsion) and footfall (rearfoot and forefoot) by ANOVA. Condition affected iEMG at pre-strike epoch. Forefoot and rearfoot strike patterns induced different EMG activation time patterns affecting co-activation index for pairs of thigh and shank muscles. All these timing changes suggest that wearing shoes or not is less important for muscle activation than the way runners strike the foot on the ground. In conclusion, the guidance for changing external forces applied on lower limbs should be pointed to the question of rearfoot or forefoot footfall patterns.

Laser Metrology In Biomechanics

NASA Astrophysics Data System (ADS)

Pryputniewicz, Ryszard J.

1983-12-01

Modern treatment of sceletal disharmonies and malocclusions utilizes application of external forces. In order to effectively use these therapeutic forces, knowledge of three-dimensional displacements of bones with correlation to biological changes is required. In the past, this problem has been studied in a number of ways using, for example, strain gauges, brittle coatings, photoelasticity, as well as clinical observations and mathematical modeling. Becouse of their inherent limitations, these techniques did not always provide all the information necessary for development of meaningful relationships between the applied force system and the resulting biological remodeling. However, recent advances in the field of la-ser metrology allowed to overcome some of the dificulties found in the earlier methods and permitted development of new techniques for non-invasive measurements of bone motions in three-dimensional space. These laser techniques are particularly useful in biomechanics because they provide for rapid and accurate determination of displacements over the entire surface of the investigate object. In this paper, application of laser techniques for quantitative in-vivo and in-vitro measurements in biomechanics will be discussed and illustrated with representative examples.

Floating electrode dielectrophoresis.

PubMed

Golan, Saar; Elata, David; Orenstein, Meir; Dinnar, Uri

2006-12-01

In practice, dielectrophoresis (DEP) devices are based on micropatterned electrodes. When subjected to applied voltages, the electrodes generate nonuniform electric fields that are necessary for the DEP manipulation of particles. In this study, electrically floating electrodes are used in DEP devices. It is demonstrated that effective DEP forces can be achieved by using floating electrodes. Additionally, DEP forces generated by floating electrodes are different from DEP forces generated by excited electrodes. The floating electrodes' capabilities are explained theoretically by calculating the electric field gradients and demonstrated experimentally by using test-devices. The test-devices show that floating electrodes can be used to collect erythrocytes (red blood cells). DEP devices which contain many floating electrodes ought to have fewer connections to external signal sources. Therefore, the use of floating electrodes may considerably facilitate the fabrication and operation of DEP devices. It can also reduce device dimensions. However, the key point is that DEP devices can integrate excited electrodes fabricated by microtechnology processes and floating electrodes fabricated by nanotechnology processes. Such integration is expected to promote the use of DEP devices in the manipulation of nanoparticles.

Observed and Projected Changes to the Precipitation Annual Cycle

DOE PAGES

Marvel, Kate; Biasutti, Michela; Bonfils, Celine; ...

2017-06-08

Anthropogenic climate change is predicted to cause spatial and temporal shifts in precipitation patterns. These may be apparent in changes to the annual cycle of zonal mean precipitation P. Trends in the amplitude and phase of the P annual cycle in two long-term, global satellite datasets are broadly similar. Model-derived fingerprints of externally forced changes to the amplitude and phase of the P seasonal cycle, combined with these observations, enable a formal detection and attribution analysis. Observed amplitude changes are inconsistent with model estimates of internal variability but not attributable to the model-predicted response to external forcing. This mismatch betweenmore » observed and predicted amplitude changes is consistent with the sustained La Niña–like conditions that characterize the recent slowdown in the rise of the global mean temperature. However, observed changes to the annual cycle phase do not seem to be driven by this recent hiatus. Furthermore these changes are consistent with model estimates of forced changes, are inconsistent (in one observational dataset) with estimates of internal variability, and may suggest the emergence of an externally forced signal.« less

Dynamics of molecular motors with finite processivity on heterogeneous tracks.

PubMed

Kafri, Yariv; Lubensky, David K; Nelson, David R

2005-04-01

The dynamics of molecular motors which occasionally detach from a heterogeneous track like DNA or RNA is considered. Motivated by recent single-molecule experiments, we study a simple model for a motor moving along a disordered track using chemical energy while an external force opposes its motion. The motors also have finite processivity, i.e., they can leave the track with a position-dependent rate. We show that the response of the system to disorder in the hopping-off rate depends on the value of the external force. For most values of the external force, strong disorder causes the motors which survive for long times on the track to be localized at preferred positions. However, near the stall force, localization occurs for any amount of disorder. To obtain these results, we study the complex eigenvalue spectrum of the time evolution operator. Existence of localized states near the top of the band implies a stretched exponential contribution to the decay of the survival probability. A similar spectral analysis also provides a very efficient method for studying the dynamics of motors with infinite processivity.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Marvel, Kate; Biasutti, Michela; Bonfils, Celine

Anthropogenic climate change is predicted to cause spatial and temporal shifts in precipitation patterns. These may be apparent in changes to the annual cycle of zonal mean precipitation P. Trends in the amplitude and phase of the P annual cycle in two long-term, global satellite datasets are broadly similar. Model-derived fingerprints of externally forced changes to the amplitude and phase of the P seasonal cycle, combined with these observations, enable a formal detection and attribution analysis. Observed amplitude changes are inconsistent with model estimates of internal variability but not attributable to the model-predicted response to external forcing. This mismatch betweenmore » observed and predicted amplitude changes is consistent with the sustained La Niña–like conditions that characterize the recent slowdown in the rise of the global mean temperature. However, observed changes to the annual cycle phase do not seem to be driven by this recent hiatus. Furthermore these changes are consistent with model estimates of forced changes, are inconsistent (in one observational dataset) with estimates of internal variability, and may suggest the emergence of an externally forced signal.« less

Quantitative analysis of the local phase transitions induced by the laser heating

DOE PAGES

Levlev, Anton V.; Susner, Michael A.; McGuire, Michael A.; ...

2015-11-04

Functional imaging enabled by scanning probe microscopy (SPM) allows investigations of nanoscale material properties under a wide range of external conditions, including temperature. However, a number of shortcomings preclude the use of the most common material heating techniques, thereby limiting precise temperature measurements. Here we discuss an approach to local laser heating on the micron scale and its applicability for SPM. We applied local heating coupled with piezoresponse force microscopy and confocal Raman spectroscopy for nanoscale investigations of a ferroelectric-paraelectric phase transition in the copper indium thiophosphate layered ferroelectric. Bayesian linear unmixing applied to experimental results allowed extraction of themore » Raman spectra of different material phases and enabled temperature calibration in the heated region. Lastly, the obtained results enable a systematic approach for studying temperature-dependent material functionalities in heretofore unavailable temperature regimes.« less

Stiffening Sheaths for Continuum Robots.

PubMed

Langer, Marlene; Amanov, Ernar; Burgner-Kahrs, Jessica

2018-06-01

Added to their high dexterity and ability to conform to complex shapes, continuum robots can be further improved to provide safer interaction with their environment. Indeed, controlling their stiffness is one of the most challenging yet promising research topics. We propose a tubular stiffening sheath as a replaceable cover for small-diameter continuum robots to temporarily increase the stiffness in a certain configuration. In this article, we assess and compare performances of two different stiffening modalities: granular and layer jamming, provide arguments for material selection and experimental results for stiffness with respect to lateral and axial applied forces. Furthermore, we detected empirically additional effects relating sheath stiffness to material parameters and added to recent investigations in the state of the art, which are based exclusively on material roughness. Finally, we integrated the selected layer jamming material in a miniaturized sheath (13 mm outer diameter, 2.5 mm wall thickness) and covered a tendon-actuated continuum robot with it. Experimental characterization of the behavior with respect to applied external forces was performed via stiffness measurements and proved that the initial tendon-actuated continuum robot stiffness can be improved by a factor up to 24.

Encoding mechano-memories in filamentous-actin networks

NASA Astrophysics Data System (ADS)

Majumdar, Sayantan; Foucard, Louis; Levine, Alex; Gardel, Margaret L.

History-dependent adaptation is a central feature of learning and memory. Incorporating such features into `adaptable materials' that can modify their mechanical properties in response to external cues, remains an outstanding challenge in materials science. Here, we study a novel mechanism of mechano-memory in cross-linked F-actin networks, the essential determinants of the mechanical behavior of eukaryotic cells. We find that the non-linear mechanical response of such networks can be reversibly programmed through induction of mechano-memories. In particular, the direction, magnitude, and duration of previously applied shear stresses can be encoded into the network architecture. The `memory' of the forcing history is long-lived, but it can be erased by force applied in the opposite direction. These results demonstrate that F-actin networks can encode analog read-write mechano-memories which can be used for adaptation to mechanical stimuli. We further show that the mechano-memory arises from changes in the nematic order of the constituent filaments. Our results suggest a new mechanism of mechanical sensing in eukaryotic cells and provide a strategy for designing a novel class of materials. S.M. acknowledges U. Chicago MRSEC for support through a Kadanoff-Rice fellowship.

Stabilization of the total force in multi-finger pressing tasks studied with the ‘inverse piano’ technique

PubMed Central

Martin, J.R.; Budgeon, M.K.; Zatsiorsky, V.M.; Latash, M.L.

2010-01-01

When one finger changes its force, other fingers of the hand can show unintended force changes in the same direction (enslaving) and in the opposite direction (error compensation). We tested a hypothesis that externally imposed changes in finger force predominantly lead to error compensation effects in other fingers thus stabilizing the total force. A novel device, the “inverse piano”, was used to impose controlled displacements to one of the fingers over different magnitudes and at different rates. Subjects (n =10) pressed with four fingers at a constant force level and then one of the fingers was unexpectedly raised. The subjects were instructed not to interfere with possible changes in the finger forces. Raising a finger caused an increase in its force and a drop in the force of the other three fingers. Overall, total force showed a small increase. Larger force drops were seen in neighbors of the raised finger (proximity effect). The results show that multi-finger force stabilizing synergies dominate during involuntary reactions to externally imposed finger force changes. Within the referent configuration hypothesis, the data suggest that the instruction “not to interfere” leads to adjustments of the referent coordinates of all the individual fingers. PMID:21450360

Dynamic mechanical control of local vacancies in NiO thin films

NASA Astrophysics Data System (ADS)

Seol, Daehee; Yang, Sang Mo; Jesse, Stephen; Choi, Minseok; Hwang, Inrok; Choi, Taekjib; Park, Bae Ho; Kalinin, Sergei V.; Kim, Yunseok

2018-07-01

The manipulation of local ionic behavior via external stimuli in oxide systems is of great interest because it can help in directly tuning material properties. Among external stimuli, mechanical force has attracted intriguing attention as novel stimulus for ionic modulation. Even though effectiveness of mechanical force on local ionic modulation has been validated in terms of static effect, its real-time i.e., dynamic, behavior under an application of the force is barely investigated in spite of its crucial impact on device performance such as force or pressure sensors. In this study, we explore dynamic ionic behavior modulated by mechanical force in NiO thin films using electrochemical strain microscopy (ESM). Ionically mediated ESM hysteresis loops were significantly varied under an application of mechanical force. Based on these results, we were able to investigate relative relationship between the force and voltage effects on ionic motion and, further, control effectively ionic behavior through combination of mechanical and electrical stimuli. Our results can provide comprehensive information on the effect of mechanical forces on ionic dynamics in ionic systems.

Dynamic mechanical control of local vacancies in NiO thin films.

PubMed

Seol, Daehee; Yang, Sang Mo; Jesse, Stephen; Choi, Minseok; Hwang, Inrok; Choi, Taekjib; Park, Bae Ho; Kalinin, Sergei V; Kim, Yunseok

2018-07-06

The manipulation of local ionic behavior via external stimuli in oxide systems is of great interest because it can help in directly tuning material properties. Among external stimuli, mechanical force has attracted intriguing attention as novel stimulus for ionic modulation. Even though effectiveness of mechanical force on local ionic modulation has been validated in terms of static effect, its real-time i.e., dynamic, behavior under an application of the force is barely investigated in spite of its crucial impact on device performance such as force or pressure sensors. In this study, we explore dynamic ionic behavior modulated by mechanical force in NiO thin films using electrochemical strain microscopy (ESM). Ionically mediated ESM hysteresis loops were significantly varied under an application of mechanical force. Based on these results, we were able to investigate relative relationship between the force and voltage effects on ionic motion and, further, control effectively ionic behavior through combination of mechanical and electrical stimuli. Our results can provide comprehensive information on the effect of mechanical forces on ionic dynamics in ionic systems.

Strain-Gated Field Effect Transistor of a MoS2-ZnO 2D-1D Hybrid Structure.

PubMed

Chen, Libo; Xue, Fei; Li, Xiaohui; Huang, Xin; Wang, Longfei; Kou, Jinzong; Wang, Zhong Lin

2016-01-26

Two-dimensional (2D) molybdenum disulfide (MoS2) is an exciting material due to its unique electrical, optical, and piezoelectric properties. Owing to an intrinsic band gap of 1.2-1.9 eV, monolayer or a-few-layer MoS2 is used for fabricating field effect transistors (FETs) with high electron mobility and on/off ratio. However, the traditional FETs are controlled by an externally supplied gate voltage, which may not be sensitive enough to directly interface with a mechanical stimulus for applications in electronic skin. Here we report a type of top-pressure/force-gated field effect transistors (PGFETs) based on a hybrid structure of a 2D MoS2 flake and 1D ZnO nanowire (NW) array. Once an external pressure is applied, the piezoelectric polarization charges created at the tips of ZnO NWs grown on MoS2 act as a gate voltage to tune/control the source-drain transport property in MoS2. At a 6.25 MPa applied stimulus on a packaged device, the source-drain current can be tuned for ∼25%, equivalent to the results of applying an extra -5 V back gate voltage. Another type of PGFET with a dielectric layer (Al2O3) sandwiched between MoS2 and ZnO also shows consistent results. A theoretical model is proposed to interpret the received data. This study sets the foundation for applying the 2D material-based FETs in the field of artificial intelligence.

The influence of gender-specific loading patterns of the stop-jump task on anterior cruciate ligament strain.

PubMed

Weinhold, Paul S; Stewart, Jason-Dennis N; Liu, Hsin-Yi; Lin, Cheng-Feng; Garrett, William E; Yu, Bing

2007-08-01

Studies have shown that women are at higher risk of sustaining noncontact anterior cruciate ligament (ACL) injuries in specific sports. Recent gait studies of athletic tasks have documented that gender differences in knee movement, muscle activation, and external loading patterns exist. The objective of this study was to determine in a knee cadaver model if application of female-specific loading and movement patterns characterised in vivo for a stop-jump task cause higher ACL strains than male patterns. Gender-specific loading patterns of the landing phase of the vertical stop-jump task were applied to seven cadaver knees using published kinetic/kinematic results for recreational athletes. Loads applied consecutively included: tibial compression, quadriceps, hamstrings, external posterior tibial shear, and tibial torque. Knee flexion was fixed based on the kinematic data. Strain of the ACL was monitored by means of a differential variable reluctance transducer installed on the anterior-medial bundle of the ACL. The ACL strain was significantly increased (P<0.05) for the female loading pattern relative to the male loading pattern after the posterior tibial shear force was applied, and showed a similar trend (P=0.1) to be increased after the final tibial torque was applied. This study suggests that female motor control strategies used during the stop-jump task may place higher strains on the ACL than male strategies, thus putting females at greater risk of ACL injury. We believe these results suggest the potential effectiveness of using training programs to modify motor control strategies and thus modify the risk of injury.

Effect of coating on properties of esthetic orthodontic nickel-titanium wires.

PubMed

Iijima, Masahiro; Muguruma, Takeshi; Brantley, William; Choe, Han-Cheol; Nakagaki, Susumu; Alapati, Satish B; Mizoguchi, Itaru

2012-03-01

To determine the effect of coating on the properties of two esthetic orthodontic nickel-titanium wires. Woowa (polymer coating; Dany Harvest) and BioForce High Aesthetic Archwire (metal coating; Dentsply GAC) with cross-section dimensions of 0.016 × 0.022 inches were selected. Noncoated posterior regions of the anterior-coated Woowa and uncoated Sentalloy were used for comparison. Nominal coating compositions were determined by x-ray fluorescence (JSX-3200, JOEL). Cross-sectioned and external surfaces were observed with a scanning electron microscope (SEM; SSX-550, Shimadzu) and an atomic force microscope (SPM-9500J2, Shimadzu). A three-point bending test (12-mm span) was carried out using a universal testing machine (EZ Test, Shimadzu). Hardness and elastic modulus of external and cross-sectioned surfaces were obtained by nanoindentation (ENT-1100a, Elionix; n  =  10). Coatings on Woowa and BioForce High Aesthetic Archwire contained 41% silver and 14% gold, respectively. The coating thickness on Woowa was approximately 10 µm, and the coating thickness on BioForce High Aesthetic Archwire was much smaller. The surfaces of both coated wires were rougher than the noncoated wires. Woowa showed a higher mean unloading force than the noncoated Woowa, although BioForce High Aesthetic Archwire showed a lower mean unloading force than Sentalloy. While cross-sectional surfaces of all wires had similar hardness and elastic modulus, values for the external surface of Woowa were smaller than for the other wires. The coating processes for Woowa and BioForce High Aesthetic Archwire influence bending behavior and surface morphology.

EEO External Relevant Labor Force Analysis

DTIC Science & Technology

1980-09-01

N 04 .- . / Washington. D.C. 20350 If. CONTROLLING OFFICE NAME AND ADDRESS Navy Personnel Research and Development Center,/, Sentber 1 8 Code 303 N-i...8217Mn. RESEARCH REPORT NO. 37 EEO EXTERNAL RELEVANT LABOR FORCE ANALYSIS D.M. ATWATER R. J. NIEHAUS’ N BY J. A. SHERIDAN ii OFFICE OF THE ASSISTANT...San Diego. CA 92152 86 I4. MONITORING AGENCY NAME & AOORESS(I diflerent ham Controlling ONce.) IS. SECURITY CLASS. (of Ihis report) oA SN (/#/F

Characterisation of acoustic energy content in an experimental combustion chamber with and without external forcing

NASA Astrophysics Data System (ADS)

Webster, S.; Hardi, J.; Oschwald, M.

2015-03-01

The influence of injection conditions on rocket engine combustion stability is investigated for a sub-scale combustion chamber with shear coaxial injection elements and the propellant combination hydrogen-oxygen. The experimental results presented are from a series of tests conducted at subcritical and supercritical pressures for oxygen and for both ambient and cryogenic temperature hydrogen. The stability of the system is characterised by the root mean squared amplitude of dynamic combustion chamber pressure in the upper part of the acoustic spectrum relevant for high frequency combustion instabilities. Results are presented for both unforced and externally forced combustion chamber configurations. It was found that, for both the unforced and externally forced configurations, the injection velocity had the strongest influence on combustion chamber stability. Through the use of multivariate linear regression the influence of hydrogen injection temperature and hydrogen injection mass flow rate were best able to explain the variance in stability for dependence on injection velocity ratio. For unforced tests turbulent jet noise from injection was found to dominate the energy content of the signal. For the externally forced configuration a non-linear regression model was better able to predict the variance, suggesting the influence of non-linear behaviour. The response of the system to variation of injection conditions was found to be small; suggesting that the combustion chamber investigated in the experiment is highly stable.

Neoclassical parallel flow calculation in the presence of external parallel momentum sources in Heliotron J

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nishioka, K.; Nakamura, Y.; Nishimura, S.

A moment approach to calculate neoclassical transport in non-axisymmetric torus plasmas composed of multiple ion species is extended to include the external parallel momentum sources due to unbalanced tangential neutral beam injections (NBIs). The momentum sources that are included in the parallel momentum balance are calculated from the collision operators of background particles with fast ions. This method is applied for the clarification of the physical mechanism of the neoclassical parallel ion flows and the multi-ion species effect on them in Heliotron J NBI plasmas. It is found that parallel ion flow can be determined by the balance between themore » parallel viscosity and the external momentum source in the region where the external source is much larger than the thermodynamic force driven source in the collisional plasmas. This is because the friction between C{sup 6+} and D{sup +} prevents a large difference between C{sup 6+} and D{sup +} flow velocities in such plasmas. The C{sup 6+} flow velocities, which are measured by the charge exchange recombination spectroscopy system, are numerically evaluated with this method. It is shown that the experimentally measured C{sup 6+} impurity flow velocities do not contradict clearly with the neoclassical estimations, and the dependence of parallel flow velocities on the magnetic field ripples is consistent in both results.« less

Regionally dependent summer heat wave response to increased surface temperature in the US

NASA Astrophysics Data System (ADS)

Lopez, H.; Dong, S.; Kirtman, B. P.; Goni, G. J.; Lee, S. K.; Atlas, R. M.; West, R.

2017-12-01

Climate projections for the 21st Century suggest an increase in the occurrence of heat waves. However, the time it takes for the externally forced signal of climate change to emerge against the background of natural variability (i.e., Time of Emergence, ToE) particularly on the regional scale makes reliable future projection of heat waves challenging. Here, we combine observations and model simulations under present and future climate forcing to assess internal variability versus external forcing in modulating US heat waves. We characterized the most common heat wave patterns over the US by the use of clustering of extreme events by their spatial distribution. For each heat wave cluster, we assess changes in the probability density function (PDF) of summer temperature extremes by modeling the PDF as a stochastically generated skewed (SGS) distribution. The probability of necessary causation for each heat wave cluster was also quantified, allowing to make assessments of heat extreme attribution to anthropogenic climate change. The results suggest that internal variability will dominate heat wave occurrence over the Great Plains with ToE occurring in the 2050s (2070s) and of occurrence of ratio of warm-to-cold extremes of 1.7 (1.7) for the Northern (Southern) Plains. In contrast, external forcing will dominate over the Western (Great Lakes) region with ToE occurring as early as in the 2020s (2030s) and warm-to-cold extremes ratio of 6.4 (10.2), suggesting caution in attributing heat extremes to external forcing due to their regional dependence.

Influences of load characteristics on impaired control of grip forces in patients with cerebellar damage.

PubMed

Brandauer, B; Timmann, D; Häusler, A; Hermsdörfer, J

2010-02-01

Various studies showed a clear impairment of cerebellar patients to modulate grip force in anticipation of the loads resulting from movements with a grasped object. This failure corroborated the theory of internal feedforward models in the cerebellum. Cerebellar damage also impairs the coordination of multiple-joint movements and this has been related to deficient prediction and compensation of movement-induced torques. To study the effects of disturbed torque control on feedforward grip-force control, two self-generated load conditions with different demands on torque control-one with movement-induced and the other with isometrically generated load changes-were directly compared in patients with cerebellar degeneration. Furthermore the cerebellum is thought to be more involved in grip-force adjustment to self-generated loads than to externally generated loads. Consequently, an additional condition with externally generated loads was introduced to further test this hypothesis. Analysis of 23 patients with degenerative cerebellar damage revealed clear impairments in predictive feedforward mechanisms in the control of both self-generated load types. Besides feedforward control, the cerebellar damage also affected more reactive responses when the externally generated load destabilized the grip, although this impairment may vary with the type of load as suggested by control experiments. The present findings provide further support that the cerebellum plays a major role in predictive control mechanisms. However, this impact of the cerebellum does not strongly depend on the nature of the load and the specific internal forward model. Contributions to reactive (grip force) control are not negligible, but seem to be dependent on the physical characteristics of an externally generated load.

An initial physical mechanism in the treatment of neurologic disorders with externally applied pico Tesla magnetic fields.

PubMed

Jacobson, J I; Yamanashi, W S

1995-04-01

The recent clinical studies describing the treatment of some neurological disorders with an externally applied pico Tesla (10(-12) Tesla, or 10(-8) gauss) magnetic field are considered from a physical view point. An equation relating the intrinsic (or rest) energy of a charged particle of mass m with its energy of interaction in an externally applied magnetic field B is presented. The equation represents an initial basic physical interaction as a part of a more complex biological mechanism to explain the therapeutic effects of externally applied magnetic fields in these and other neurologic disorders.

A physical mechanism in the treatment of neurologic disorders with externally applied pico Tesla magnetic fields.

PubMed

Jacobson, J I; Yamanashi, W S

1995-06-01

The clinical studies describing the treatment of some neurological disorders with an externally applied pico Tesla (10R Tesla, or 10(-8) gauss) magnetic field are considered from a physical view point. An equation relating the intrinsic or "rest" energy of a charged particle of mass with its energy of interaction in an externally applied magnetic field B is presented. The equation is proposed to represent an initial basic physical interaction as a part of a more complex biological mechanism to explain the therapeutic effects of externally applied magnetic fields in these and other neurologic disorders.

The external respiration and gas exchange in space missions

NASA Astrophysics Data System (ADS)

Baranov, V. M.; Tikhonov, M. A.; Kotov, A. N.

Literature data and results of our own studies into an effect of micro- and macro-gravity on an external respiration function of man are presented. It is found that in cosmonauts following the 7-366 day space missions there is an enhanced tendency associated with an increased flight duration toward a decrease in the lung volume and breathing mechanics parameters: forced vital capacity of the lungs (FVC) by 5-25 percent, peak inspiratory and expiratory (air) flows (PIF, PEF) by 5-40 percent. A decrease in FVC appears to be explained by a new balance of elastic forces of the lungs, chest and abdomen occuring in microgravity as well as by an increased blood filling and pulmonary hydration. A decline of PIF and PEF is probalbly resulted from antigravitational deconditioning of the respiratory muscles with which a postflight decreased physical performance can in part be associated. The ventilation/perfusion ratios during orthostasis and +G Z and +G X accelerations are estimated. The biophysical nature of developing the absorption atelectases on a combined exposure to accelerations and 100% oxygen breathing is confirmed. A hypothesis that hypervolemia and pulmonary congestion can increase the tendency toward the development of atelectases in space in particular during pure oxygen breathing is suggested. Respiratory physiology problem area which is of interest for space medicine is defined. It is well known that due to present-day technologic progress and accomplishments in applied physiology including applied respiration physiology there currently exist sophisticated technical facilities in operation maintaining the life and professional working capacity of a man in various natural environments: on Earth, under water and in space. By the way, the biomedical involvement in developing and constructing such facilities has enabled an accumulation of a great body of information from experimental studies and full-scale trails to examine the effects of the changed environments both and its individual systems including an external respiration function. In this case, it should be remembered that the external respiration system has some physiological and morphological properties due to which the body systems are particularly subjected to environmental effects. Thus, according to figurative comparison by Evald Veible a contact area of the lungs with an external environment i.e. an alveolar surface is large and equaled approximately to tennis-court size, as the alveolocapillary membrane thickness is negligible and amounts to one fiftieth of a writing-paper sheet [1]. From this it follows that such a fine and highly organized structure must be extremely dependent upon any external exposures including gravitational ones since from the physical viewpoint of physics the lungs represent a quasiconical three-dimensional elastic body suspended in the thoracic cavity and in which there occur the gravity-induced internal tensions incrementing in a base-to-apices direction. As a result of these tensions, in the lungs various physical gradients: hydrostatic, pleural and transpulmonary pressures, pulmonary time constant, vertical gradient of the volume and structure of alveoli, etc. are developed.